최강열
발표논문

Cho YH, Ro EJ, Yoon JS, Mizutani, T., Kang, DW, and Choi, KY. 5-FU promotes stemness of colorectal cancer via p53-mediated Wnt/β-catenin pathway activation. Nature Communications. 11:5321. (2020)
Jeong, WJ, Park, JC, Kim, WS, Ro, EJ, Jeon, SH, Lee, SK, Park YN, Min, DS, and Choi, KY. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Nature Communications. 10(1):295. doi: 10.1038/s41467-018-08230-6. (2019)
Lee, SK, WJ, Cho, YH, Cha, PH, Yoon JS, Ro EJ, Choi SH, Oh, JM, Heo,YS, Kim H, Min, DS, Han, G, Lee, W, Choi. KY. β-Catenin-RAS interaction serves as molecular switch for RAS degradation via GSK3β. EMBO Reports pii; e46060 (2018)
Cha PH, Cho YH, Lee SK, Lee JH, Jeong W-J, Moon B-S, Yun JH, Yang JS, Choi SH, Yoon JY, Kim HY, Kim, MY, Kaduwal S, Lee W, Min DS, Kim Hg, Han GH, and Choi KY. Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation. Nature Chemical Biology. 12, 593-600 (2016)
Kim, HY, Choi, S, Yoon JH, Lim HJ, Lee H, Choi J, Neo JN, Lee W, No, KT, and Choi, KY. Small molecule inhibitors of Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Molecular Medicine 8, 375-387 (2016)
Kim, MY., Kim HY, Hong J., Kim D, Lee H, Cheong, E., Lee, Yangsin, Roth J., Kim, DG, Min DS., and Choi, KY. CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. Glia. 64(3), 350-362. (2016)
Lee SH, Kim MY, Kim HY, Lee YM, Kim HS, Nam KA, Roh MR, Min DS, Chung KY, and Choi KY. The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. Journal of Experimental Medicine. 212(7):1061-80. (2015)
Kim HY, Yoon JY, Yoon JH, Cho KW, Lee, SH, Rhee, YM, Jung, HS, Lim HJ, Choi, JW, Heo JN, Lee WT, No KT, Min DS, and Choi KY. CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Cell Death and Differentiation. 22(6):912-20. (2015)
Moon, BS, Jeong, WJ, Park, J, Kim, TI, Min DS, and Choi, KY. Oncogenic K-Ras Accelerates Cancer Stem Cell Activation via Aberrant Wnt/beta-catenin Signaling. JNCI-Journal of the National Cancer Institute. 106(2):djt 373. (2014)
Moon, BS, Cho, Y.H. Jeong, WJ, and Choi, KY. Response. JNCI-Journal of the National Cancer Institute. 106 (8): dju 197. (2014)
Kim HY, Yang DH, Shin SW, Kim MY, Yoon JH, Kim S, Park HC, Kang DW, Min DS, Hur MW, and Choi KY. CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation. FASEB Journal. 28(2), 615-26. (2014)
Zahoor M, Cha PH, and Choi KY. Indirubin-3'-Oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restore bone loss in high-fat diet-induced obese male mice. Bone. 65:60-68. (2014)
Zahoor M, Cha PH, Min DS, and Choi KY. Indirubin-3’-oxime Reverses Bone Loss in Ovariectomized and Hindlimb-Unloaded Mice via Activation of the Wnt/β-Catenin Signaling. Journal of Bone and Mineral Research. 29:1196-1205. (2014)
Choi OM, Cho YH, Choi S, Lee SH, Seo SH, Kim HY, Han GH, Park TS, Min DS, and Choi KY. The small molecule indirubin-3´-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity. International Journal of Obesity. 38:1044-52. (2014)
Kim MY, Moon BS, and Choi KY. Isolation and maintenance of cortical neural progenitor cells in vitro. Methods in Molecular Biology. 1018:3-10. (2013) (IF=1.29) (“BookChapter”-Springer)
Jeong WJ, Yoon JY, Park JC, Lee SH, Lee SH, Kaduwal S, Kim HG, Yoon JB, and Choi KY. Ras Stabilization via Aberrant Activation of Wnt/b-catenin Signaling Promotes Intestinal Tumorigenesis. Science Signaling. 5(219):ra30. (2012)
Yoon JY, Koo KH, and Choi KY. MEK1/2 Inhibitors, AS703026 and AZD6244, may be potential therapies for K-ras Mutated Colorectal Cancer that Is resistant to EGFR Monoclonal Antibody Therapy. Cancer Research. 71(2):445-53. (2011)
Moon BS, Kim HY, Kim MY, Yang DH, Lee JM, Cho KW, Jung HS, and Choi KY. Sur8/Shoc2 Involves Both Inhibition of Differentiation and Maintenance of Self-renewal of Neural Progenitor Cells via Modulation of ERK Signaling. Stem Cells. 29:320-31 (2011)
Yang DH, Yoon JY, Lee SH, Bryja V, Andersson ER, Arenas E, Kwon YG, and Choi KY. Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/β-Catenin and Protein Kinase Ca. Circulation Research. 104(3):372-9. (2009)
Schumacher MA, Choi KY, Lu F, Zalkin H, and Brennan RG. Mechanism of corepressor-mediated specific DNA binding by the purine repressor. Cell. 83(1):147-55. (1995)
Choi KY, Satterberg B, Lyons DM, and Elion EA. Ste5 thether multiple protein kinase in the MAP kinase cascade required for mating in Saccharomyces cerevisiae. Cell. 78(3):499-512. (1994)
Schumacher MA, Choi KY, Zalkin H, and Brennan RG. Crystal structure of LacI member RurR, bound to DNA: Minor groove binding by  α helices. Science. 266(5186):763-70. (1994)