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연구 논문

Kang-Il Kim, Myung Chul Lee, Ju Hong Lee, Young-Wan Moon, Woo-Suk Lee, Han-Jun Lee, Sun-Chul Hwang, Yong In, Oog-Jin Shon, Ki-Cheor Bae, Sang-Jun Song, Kwan Kyu Park, Jun-Ho Kim.
Clinical Efficacy and Safety of the Intra-articular Injection of Autologous Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis. Am J Sports Med. 2023 Jun 21. DOI: 10.1177/03635465231179223. PMID: 37345256
Jun-Ho Kim, Kang-Il Kim, Wan Keun Yoon, Sang-Jun Song, Wook Jin.
Intra-articular Injection of Mesenchymal Stem Cells after High Tibial Osteotomy in Osteoarthritic Knee: Two-Year Follow-up of Randomized Control Trial. Stem Cells Translational Med. 2022 Jun 8;szac023. doi: 10.1093/stcltm/szac023. PMID: 35674255
Kang-Il Kim, Woo-Suk Lee, Jun-Ho Kim, Jung-Kwon Bae, Wook Jin.
Safety and Efficacy of the Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritic Knee: A 5-Year Follow-up Study. Stem Cells Translational Med. 2022 May 14;szac024. doi: 10.1093/stcltm/szac024. PMID: 35567774
Ra K, Oh HJ, Kim EY, Kang SK, Ra JC, Kim EH, Lee BC.
Anti-Oxidative Effects of Human Adipose Stem Cell Conditioned Medium with Different Basal Medium during Mouse Embryo In Vitro Culture. Animals 2020 Aug 13;10(8):1414. doi: 10.3390/ani10081414. PMID 32823702
Ra K, Oh HJ, Kim GA, Kang SK, Ra JC, Lee BC.
High Frequency of Intravenous Injection of Human Adipose Stem Cell Conditioned Medium Improved Embryo Development of Mice in Advanced Maternal Age through Antioxidant Effect. Animals 2020, 10, 978; doi:10.3390/ani10060978
Lee SH, Ra JC, Oh HJ, Kim MJ, Setyawan EMN, Choi YB, Yang JW, Kang SK, Han SH, Kim GA, Lee BC.
Clinical Assessment of Intravenous Endothelial Progenitor Cell ransplantation in Dogs. Cell Transplant. 2019 Jul;28(7):943-954. doi: 10.1177/0963689718821686. Epub 2019 Apr 24. PMID 31018670
Shin K, Cha Y, Ban YH, Seo DW, Choi EK, Park D, Kang SK, Ra JC, Kim YB.
Anti-osteoarthritis effect of a combinational treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbit. World J Stem cells 11(12): 1115-1129. PMID 31875872.
Park CH, Yang PS, Yoon YS, Ra JC
Study on the safety of Polygala tenuifolia Willdenow root extract powder (BT-11) in young person aged from 9 to 19 years old - J Ethnopharmacol, 2019 Mar; 25232:119-129 PMID 30576772
Kim GA, Lee Y, Kim HJ, Oh HJ, Kang SK, Ra JC, Lee BC
Intravenous human endothelial progenitor cell administration into aged mice enhances embryo development and oocyte quality by reducing inflammation, endoplasmic reticulum stress and apoptosis. - J Vet Med Sci, 2018 Dec; 2680(12):1905-1913 PMID 30369585
Jeong-Chan Ra
A Novel Approach to Developing in Vitro Culture Method for Enhancing Anti-Cancer Nature of ADMSCs," Current Trends in Biomedical Engineering & Biosciences, 2018. vol. 11(4), pages 78-79, January.
Jeong-Chan Ra, Hyo Jung Choi and Yoon Kim
Effect of Multiple Intrathecal Administrations of Cultured Human Autologous Adipose-Derived Stem Cells in the Patients with Neurological Disorders Including Parkinson’s Disease -J Clin Case Rep 2018, Vol 8(10): 1183. DOI 10.4172/2165-7920.10001183 바로가기
Lee SH, Setyawan EMN, Choi YB, Ra JC, Kang SK, Lee BC, Kim GA
Clinical assessment after human adipose stem cell transplantation into dogs. - J Vet Sci, 2018 May; 3119(3):452-461 PMID 29284215
Jeong-Chan Ra, Yun-Joung Kim and Eun-Young Kim
Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels - J Clin Case Rep 2017, Vol 7(11): 1040. DOI: 10.4172/2165-7920.10001040 바로가기
Ra JC, Jeong EC, Kang SK, Lee SJ, Choi KH
A Prospective, Nonrandomized, no Placebo-Controlled, Phase I/II Clinical Trial Assessing the Safety and Efficacy of Intramuscular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in Patients With Severe Buerger's Disease. - Cell Med, 2016 Oct; 39(3):87-102 PMID 28713639
Ha S, Park H, Mahmood U, Ra JC, Suh YH, Chang KA.
Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model. Behav Brain Res. 2017 Jan 15;317:479-484. doi: 10.1016/j.bbr.2016.10.004. Epub 2016 Oct 4. PMID: 27717813.
Kim D, Kyung J, Park D, Choi EK, Kim KS, Shin K, Lee H, Shin IS, Kang SK, Ra JC, Kim YB
Health Span-Extending Activity of Human Amniotic Membrance-and Adipose Tissue-Derived Stem Cells in F344 Rats - Stem Cells Transl Med, 2015 Oct;4(10):1144-1154 PMID 26315571
Han SM, Park CW, Ahn Jo, Park SC, Jung WS, Seo KW, Ra JC, Kang SK Lee HW, Youn HY
Pro-apoptotic and Growth-inhibitory Effect of IFN-β-Overexpressing Canine Adipose Tissue-derived Mesenchymal Stem Cells Against Melanoma Cells - Anticancer Res, 2015 Sep;35(9):4749-4756 PMID 26254365
Choi HS, Kim HJ, Oh JH, Park HG, Ra JC, Chang KA, Suh YH
Therapeutic potentials of human adipose-derived stem cells on the mouse model of Parkinson's disease - Neurobiol Aging, 2015 Oct;36(10):2885-92 PMID 26242706
Han SH, Jang G, Bae BK, Han SM, Koh YR, Ahn JO, Kang SK, Ra JC, Lee HW, et al.
Effect of ectopic OCT4 expression on canine adipose tissue-derived mesenchymal stem cell proliferation. - Cell Biol Int 2014 Oct;38(10):1163-73 PMID 24797505
Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Ra JC, Oh S, Yoon KS.
Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial - Stem Cells, 2014 May;32(5):1254-1266 PMID 24449146
Kim KS, Lee HJ, Kim YB, Ra JC, Lim I, Kim SU
Transplantation of Human Adipose Tissue-Derived Stem Cells Delays Clinical Onset and Prolongs Life Span in ALS Mouse Model - Cell Transplant, 2014;23(12):1585-1597 PMID 24070071
Han SM, Han SH, Coh YR, Jang G, Ra JC , Kang SK, Lee HW, Youn HY
Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells - Exp Mol Med, 2014 Jun 20; 46:e101 PMID 24946789
Choi YK, Din FU, Kim DW, Kim YI, Kim JO, Ku SK, Ra JC, Huh JW, Lee JI, Sohn DH et al.
Amniotic membrane extract-loaded double-layered wound dressing: evaluation of gel properties and wound healing - Drug Dev Ind Pharm 2014, 40(7):852-859 PMID 23621769
Choi SW, Park KB, Woo SK, Kang SK, Ra JC
Treatment of progressive supranuclear palsy with autologous adipose tissue-derived mesenchymal stem cells: a case report - J Med Case Rep, 2014 Mar 4; 8:87 PMID 24594311
Choi JW, Park EJ, Shin HS, Shin IS, Ra JC Koh KS
In Vivo Differentiation of Undifferentiated human adipose tissue-derived mesenchymal stem cells in critical-sized calvarial bone defects. - Ann Plast Surq. 2014 Feb;72(2):225-233 PMID 23221992
Choi EW, Shin IS, Park SY, Yoon EJ, Kang SK, Ra JC, Hong SH
Characteristics of mouse Adipose Tissue-Derived stem cells and therapeutic Comparisons Between syngeneic and allogeneic adipose tissue-derived stem cell transplantation in experimental autoimmune thyroiditis - Cell Transplant. 2014;23(7):873-887 PMID 23485102
Kim YM, Oh SH, Choi JS, Lee S, Ra JC, Lee JH, Lim JY
Adipose-Derived Stem Cell-Containing Hyaluronic Acid/Alginate Hydrogel Improves Vocal Fold Wound Healing - Larynqoscope. 2014 Mar, 124(3):E64-72 PMID 24115025
Roy R, Kukucka M, Messroghli D, Kunkel D, Brodarac A, Klose K, Geiβler S, Becher PM, Kang SK, Choi YH, Stamm C
Epithelial to mesenchymal transition enhances the cardioprotective capacity of human amniotic epithelial cells. Cell Transplant. 2013 Nov 20, 2015;24(6):985-1002 PMID: 24256742
Park DS, Yang G, Bae DK, Lee SH, Yang YH, Kim D, Choi EK, Kang SK, Ra JC, Kim YB.
Human Adipose Tissue-Derived Mesenchymal stem cells improve cognitive Function and Physical Activity in Ageing Mice - J Neurosci Res, 2013 May 91(5):660-670 PMID 23404260
Park DS, Lee SH, Bae DK, Yang YH, Yang G, Kyung JB, Kim D, Choi EK, Hong JT, Shin IS, Kang SK, Ra JC, Kim YB.
Transplantation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Restores the Neurobehavioral Disorders of Rats With Neonatal Hypoxic-Ischemic Encephalopathy - Cell Med 2013 Feb 7;5(1):17-28 PMID 26858861
Lim J-Y, Ra JC, Shin IS, Jang YH, An HY, Choi JS, Kim WC, Kim YM.
Systemic Transplantation of Human Adipose Tissue-Derived Mesenchymal Stem Cells for the Regeneration of Irradiation-Induced Salivary Gland Damage - PLoS One,2013 Aug, 8(8):e71167. PMID 23951100
Ahn JO, Lee HW, Seo KW, Kang SK, Ra JC, Youn HY.
Anti-Tumor Effect of Adipose Tissue Derived-Mesenchymal Stem Cells Expressing Interferon-β and Treatment with Cisplatin in a Xenograft Mouse Model for Canine Melanoma - Plos One,2013 Sep, 8(9): e74897. PMID 24040358
Kim IG, S Piao, JY Lee, SH Hong, TK Hwang, SW Kim, CS Kim, JC Ra, I Noh and JY Lee.
Effect of an Adipose Derived Stem Cells and Nerve Growth Factor-Incorporated Hydrogel on Recovery of Erectile Function in a Rat Model of Cavernous Nerve Injury. - Tissue Engineering. Part A .2013, 19 (1-2):14-23. PMID 22834730
Kim S, Chang KA, Kim JA, Park HG,Ra JC, Kim HS, Suh YH
The Preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice. - PLoS One. 2012;7(9):e45757P PMID 23049854
Oh HJ, EJ Park, SY Lee, JW Soh, IS Kong, SW Choi, JC Ra, SK Kang and BC Lee.
Comparison of cell proliferation and epigenetic modification of gene expression patterns in canine foetal fibroblasts and adipose tissue-derived mesenchymal stem cells. - Cell Proliferation. 2012. 45:438?444. PMID 22925503
Kim MJ, Oh HJ, Kim GA, Park JE, Park EJ, Jang G, Ra JC, Kang SK, Lee BC.
Lessons learned from cloning dogs. -Reprod Domest Anim. 2012 Aug;47 Suppl 4:115-9 PMID 22827359
Koh KS, TS Oh, H Kim, IW Chung, KW Lee, HB Lee, EJ Park, IS Shin, JC Ra and JW Choi.
Clinical application of human adipose tissue-derived mesenchymal stem cells in progressive hemifacial atrophy (parry-romberg disease) with microfat grafting techniques using 3-dimensional computed tomography and 3-dimensional camera. - Annals of Plastic Surgery 2012. 69:331-337. PMID 22907186
Fang CH, J Jin, JH Joe, YS Song, BI So, SM Lim, SK Woo, JC Ra, YY Lee and KS Kim.
In Vivo Differentiation of Human Amniotic Epithelial Cells into Cardiomyocyte-Like Cells and Cell Transplantation Effect on Myocardial Infarction in Rats: Comparison with Cord Blood and Adipose Tissue-Derived Mesenchymal Stem Cells. - Cell Transplantation. 2012. PMID 22776022
Piao S, Kim IG, Lee JY, Hong SH, Kim SW Hwang TK, Oh SH, Lee JH, Ra JC, Lee JY
Therapeutic Effect of Adipose-Derived Stem Cells and BDNF-immobilized PLGA Membrane in a Rat Model of Cavernous Nerve Injury - J Sex Med. 2012 May 29. doi: 10.1111/j.1743-6109.2012.02760.x. PMID 22642440
Park YS, Lim GW, Cho KA, Woo SY, Shin M, Yoo ES, Ra JC, Rhy KH.
Improved viability and activity of neutrophils differentiated from HL-60 cells by co-culture with adipose tissue-derived mesenchymal stem cells - BBRC 2012, in press PMID 22609208
Kang SK, Shin IS, Ko MS, Jo JY, Ra JC.
Journey of Mesenchymal Stem Cells for Homing: Strategies to Enhance Efficacy and Safety of Stem Cell Therapy. (Review article) - Stem Cells Int. 2012;2012:342968. Epub 2012 Jun 13. PMID 22754575
Kang JW, Koo HC, Hwang SY, Kang SK, Ra JC, Lee MH, Park YH.
Immunomodulatory effects of human amniotic membrane-derived mesenchymal stem cells. - Journal of Veterinary Science 2012, 13(1):23-31. PMID 22437532
Choi EW, Shin IS, Park SY, Park JH, Kim JS, Yoon EJ, Kang SK, Ra JC, Hong SH.
Reversal of serological, immunological and histological dysfunction in systemic lupus erythematosus mice by long-term serial adipose tissue-derived mesenchymal stem cell transplantation. - Arthritis Rheum. 2012, ;64(1):243-53. PMID 21904997
Kwon EB , Lee JY, Piao S, Kim IG, Ra JC, Lee JY
Comparison of human muscle-derived stem cells and human adipose derived stem cells in neurogenic trans-differentiation
- Korean J Urol. 2011 Dec;52(12):852-7 PMID 22216399
Ra JC, Kang SK, Shin IS, Park HG, Joo SA, Kim JG, Kang BC, Lee YS, Nakama K, Piao M, Sohl B, Kurtz A.
Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells. - J Trans Med 2011, 9(1):18. PMID 22017805
Baek SJ, Kang SK, Ra JC.
In vitro migration capacity of human adipose-derived mesenchymal stem cells and their expression of a distinct set of chemokine and growth factor receptors. - EXPERIMENTAL and MOLECULAR MEDICINE, 43,(10), 596-603. PMID 21847008
Kim MJ, Oh HJ, Park JE, Kim GA, Hong SG, Jang G, Kwon MS, Koo BC, Kim T, Kang SK, Ra JC, Ko C, Lee BC
Generation of transgenic dogs that conditionally express green fluorescent protein. - Genesis. 2011, 49(6):472-8. PMID 21630415
Ko MS, Park HG, Yun YM, Ra JC, Shin T, Lee KK
The ameliorative effects of human adipose tissue-derived mesenchymal stem cells (hAdMSCs) on MBP-induced einduced e induced e xperimental autoimmune encephalomyelitis (EAE) in Lewis rats. - Neural Regen Res. 2011, 6(16):1205-1210
Hwang JH, Kim IG, Lee JY, Piao S, Lee DS, Lee TS, Ra JC, Lee JY
Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel.- Biomaterials. 2011, 32(19):4415-23. PMID 21421266.
Ko MS, Jung JY, Shin IS, Choi EW, Kim JH, Kang SK, Ra JC
Effects of Expanded Human Adipose Tissue -Derived Mesenchymal Stem Cells on the Viability of Cryopreserved Fat Grafts in the Nude Mouse. - 2011; 8(3):231-238 PMID 21448310.
Choi HJ, Kim JM, Kwon E, Che JH, Lee JI, Cho SR, Kang SK, Ra JC, Kang BC
Establishment of Efficacy and Safety Assessment Human Adipose Tissue-Derived Mesenchymal Stem Cells (hATMSCs) in a Nude Rat Femoral segmental Defect Model - Korean Med Sci 2011; 26: 482-491 PMID 21468254
Ra JC , Shin IS, Kim SH, Kang SK, Kang BC, Lee HY, Kim YJ, jo JY, Yoon EJ, Choi HJ, Kwon E
Safety of intravenous infusion of human adipose tissue derived mesenchymal stem cells in animals and humans - Stem Cells Dev. 2011, 20(8):1297-1308. PMID 21303266
Choi EW, Shin IS, Lee HW, Park SY, Park JH, Nam MH, Kim JS, Woo SK, Yoon EJ, Kang SK, Ra JC, Woun HY, Hing SH
Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. - The Journal of Gene Medicine. 2011 13(1): 3-16 PMID 21259404.
Oh HJ, Park JE, Kim MJ, Hong SG, Ra JC, Jo JY, Kang SK, Jang G, Lee BC
Recloned dogs derived from adipose stem cells of a transgenic cloned beagle. - Theriogenology 75 (2011) 1221-1231 PMID 21220163.
Kim BH, Son WC, Yim CO, Kang SK, Yim CO, Ra JC, Kim YC.
Anti-Wrinkle Effects of Adipose Tissue-Derived Mesenchymal Stem Cells in a UV-Irradiated Hairless Mouse Model. - Tissue Engineering and Regenerative Medicine. 2010;7(5):583-591
Woo SK, Jo JY, Shin IS, Kang SK, Ra JC
New Isolation Technique and Culture System for Clinical Applications of Human Amniotic Epithelial Stem Cells.- Development and Reproduction 2009;13(4):271-280
Jo JY, Kang SK, Choi IS, Ra JC.
Comparison of Neural Cell Differentiation Mesenchymal Stem Cells Derived from Young and Old Ages. - Development and Reproduction 2009;13(4):227-237
Hong SG, Kim MK, Jang G, Oh HJ, Park JE, Kang JT, Koo OJ, Kim T, Kwon MS, Koo BC, Ra JC, Kim DY, Ko C, Lee BC
Generation of red fluorescent protein transgenic dogs. - Genesis. 2009, 47(5): 314-22 PMID 19358155.
Jo EH, Kim SH, Ra JC, Kim SR, Cho SD, Jung JW, Yang SR, Park JS, Hwang JW, Aruoma OI, Kim TY, Lee YS, Kang KS.
Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett. 2005 Dec 18;230(2):239-47. doi: 10.1016/j.canlet.2004.12.038.PMID: 16297710.