第X因子
関連図書

Cooper DN, Millar DS, Wacey A (1997). “Inherited factor X deficiency: molecular genetics and pathophysiology”. Thromb. Haemost. 78 (1):  161–72. PMID 9198147.
Hassan HJ, Leonardi A, Chelucci C (1990). “Blood coagulation factors in human embryonic-fetal development: preferential expression of the FVII/tissue factor pathway”. Blood 76 (6):  1158–64. PMID 1698100.
Messier TL, Pittman DD, Long GL (1991). “Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X”. Gene 99 (2):  291–4. doi:10.1016/0378-1119(91)90141-W. PMID 1902434.
Krishnaswamy S (1990). “Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation”. J. Biol. Chem. 265 (7):  3708–18. PMID 2303476.
España F, Berrettini M, Griffin JH (1989). “Purification and characterization of plasma protein C inhibitor”. Thromb. Res. 55 (3):  369–84. doi:10.1016/0049-3848(89)90069-8. PMID 2551064.
Fung MR, Hay CW, MacGillivray RT (1985). “Characterization of an almost full-length cDNA coding for human blood coagulation factor X”. Proc. Natl. Acad. Sci. U.S.A. 82 (11):  3591–5. doi:10.1073/pnas.82.11.3591. PMC 397831. PMID 2582420. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC397831/.
Jagadeeswaran P, Reddy SV, Rao KJ (1990). “Cloning and characterization of the 5' end (exon 1) of the gene encoding human factor X”. Gene 84 (2):  517–9. doi:10.1016/0378-1119(89)90529-5. PMID 2612918.
Reddy SV, Zhou ZQ, Rao KJ (1989). “Molecular characterization of human factor XSan Antonio”. Blood 74 (5):  1486–90. PMID 2790181.
Kaul RK, Hildebrand B, Roberts S, Jagadeeswaran P (1986). “Isolation and characterization of human blood-coagulation factor X cDNA”. Gene 41 (2–3):  311–4. doi:10.1016/0378-1119(86)90112-5. PMID 3011603.
Broze GJ, Warren LA, Novotny WF (1988). “The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action”. Blood 71 (2):  335–43. PMID 3422166.
Gilgenkrantz S, Briquel ME, André E (1986). “Structural genes of coagulation factors VII and X located on 13q34”. Ann. Genet. 29 (1):  32–5. PMID 3487272.
Leytus SP, Foster DC, Kurachi K, Davie EW (1986). “Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C”. Biochemistry 25 (18):  5098–102. doi:10.1021/bi00366a018. PMID 3768336.
Leytus SP, Chung DW, Kisiel W (1984). “Characterization of a cDNA coding for human factor X”. Proc. Natl. Acad. Sci. U.S.A. 81 (12):  3699–702. doi:10.1073/pnas.81.12.3699. PMC 345286. PMID 6587384. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC345286/.
McMullen BA, Fujikawa K, Kisiel W (1983). “Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid”. Biochemistry 22 (12):  2875–84. doi:10.1021/bi00281a016. PMID 6871167.
Marchetti G, Castaman G, Pinotti M (1995). “Molecular bases of CRM+ factor X deficiency: a frequent mutation (Ser334Pro) in the catalytic domain and a substitution (Glu102Lys) in the second EGF-like domain”. Br. J. Haematol. 90 (4):  910–5. doi:10.1111/j.1365-2141.1995.tb05214.x. PMID 7669671.
Morgenstern KA, Sprecher C, Holth L (1994). “Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases”. Biochemistry 33 (11):  3432–41. doi:10.1021/bi00177a037. PMID 8136380.
Heeb MJ, Rosing J, Bakker HM (1994). “Protein S binds to and inhibits factor Xa”. Proc. Natl. Acad. Sci. U.S.A. 91 (7):  2728–32. doi:10.1073/pnas.91.7.2728. PMC 43443. PMID 8146182. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43443/.
Inoue K, Morita T (1993). “Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X”. Eur. J. Biochem. 218 (1):  153–63. doi:10.1111/j.1432-1033.1993.tb18361.x. PMID 8243461.
Padmanabhan K, Padmanabhan KP, Tulinsky A (1993). “Structure of human des(1-45) factor Xa at 2.2 A resolution”. J. Mol. Biol. 232 (3):  947–66. doi:10.1006/jmbi.1993.1441. PMID 8355279.
Sinha U, Wolf DL (1993). “Carbohydrate residues modulate the activation of coagulation factor X”. J. Biol. Chem. 268 (5):  3048–51. PMID 8428982.
|  PDBギャラリー |
| --- | --- |
  1c5m: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR  1ezq: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515  1f0r: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815  1f0s: Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707  1fax: COAGULATION FACTOR XA INHIBITOR COMPLEX  1fjs: CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA  1g2l: FACTOR XA INHIBITOR COMPLEX  1g2m: FACTOR XA INHIBITOR COMPLEX  1hcg: STRUCTURE OF HUMAN DES(1-45) FACTOR XA AT 2.2 ANGSTROMS RESOLUTION  1ioe: Human coagulation factor Xa in complex with M55532  1iqe: Human coagulation factor Xa in complex with M55590  1iqf: Human coagulation factor Xa in complex with M55165  1iqg: Human coagulation factor Xa in complex with M55159  1iqh: Human coagulation factor Xa in complex with M55143  1iqi: Human coagulation factor Xa in complex with M55125  1iqj: Human coagulation factor Xa in complex with M55124  1iqk: Human coagulation factor Xa in complex with M55113  1iql: Human coagulation factor Xa in complex with M54476  1iqm: Human coagulation factor Xa in complex with M54471  1iqn: Human coagulation factor Xa in complex with M55192  1ksn: Crystal Structure of Human Coagulation Factor XA Complexed with FXV673  1kye: Factor Xa in complex with (R)-2-(3-adamantan-1-yl-ureido)-3-(3-carbamimidoyl-phenyl)-N-phenethyl-propionamide  1lpg: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79.  1lpk: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125.  1lpz: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 41.  1lqd: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45.  1mq5: Crystal Structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa  1mq6: Crystal Structure of 3-chloro-N-[4-chloro-2-[[(5-chloro-2-pyridinyl)amino]carbonyl]-6-methoxyphenyl]-4-[[(4,5-dihydro-2-oxazolyl)methylamino]methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa  1nfu: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR132747  1nfw: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR209685  1nfx: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208944  1nfy: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR200095  1p0s: Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R  1v3x: Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine  1wu1: Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine  1xka: FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID  1xkb: FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID  1z6e: Crystal Structure of Factor Xa complexed to Razaxaban  2bmg: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 50  2boh: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND ""1""  2bok: FACTOR XA - CATION  2bq6: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 21  2bq7: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 43  2bqw: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45  2cji: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX  2d1j: Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide  2fzz: Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one  2g00: Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide  2gd4: Crystal Structure of the Antithrombin-S195A Factor Xa-Pentasaccharide Complex  2h9e: Crystal Structure of FXa/selectide/NAPC2 ternary complex  2j2u: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX  2j34: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX  2j38: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX  2j4i: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX  2j94: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX  2j95: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX  2uwl: SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA  2uwo: SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA  2uwp: FACTOR XA INHIBITOR COMPLEX  
Blood coagulation pathways in vivo showing the central role played by thrombin