レチナール
関連文献

Prado-Cabrero, Alfonso; Scherzinger, Daniel; Avalos, Javier; Al-Babili, Salim (2007). “Retinal Biosynthesis in Fungi: Characterization of the Carotenoid Oxygenase CarX from Fusarium fujikuroi”. Eukaryotic Cell 6 (4):  650–657. doi:10.1128/EC.00392-06. PMC 1865656. PMID 17293483. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865656/.
Kloer, Daniel P.; Ruch, Sandra; Al-Babili, Salim; Beyer, Peter; Schulz, Georg E. (2005). “The Structure of a Retinal-Forming Carotenoid Oxygenase”. Science 308 (5719):  267–269. Bibcode: 2005Sci...308..267K. doi:10.1126/science.1108965. PMID 15821095. https://semanticscholar.org/paper/cb03a4e113294f0e3c17b9d7d5503c993f26dbb8.
Schmidt, Holger; Kurtzer, Robert; Eisenreich, Wolfgang; Schwab, Wilfried (2006). “The Carotenase AtCCD1 from Arabidopsis thaliana Is a Dioxygenase”. Journal of Biological Chemistry 281 (15):  9845–9851. doi:10.1074/jbc.M511668200. PMID 16459333.
Wang, Tao; Jiao, Yuchen; Montell, Craig (2007). “Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction”. Journal of Cell Biology 177 (2):  305–316. doi:10.1083/jcb.200610081. PMC 2064138. PMID 17452532. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064138/.
Wald, George (1967年). “Nobel Lecture: The Molecular Basis of Visual Excitation”. 2009年2月23日閲覧。
Fernald, Russell D. (2006). “Casting a Genetic Light on the Evolution of Eyes”. Science 313 (5795):  1914–1918. Bibcode: 2006Sci...313.1914F. doi:10.1126/science.1127889. PMID 17008522.
Briggs, Winslow R.; Spudich, John L., eds (2005). Handbook of Photosensory Receptors. Wiley. ISBN 978-3-527-31019-7
Baylor, D A; Lamb, T D; Yau, K W (1979). “Responses of retinal rods to single photons”. Journal of Physiology 288:  613–634. doi:10.1113/jphysiol.1979.sp012716. PMC 1281447. PMID 112243. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1281447/.
Hecht, Selig; Shlaer, Simon; Pirenne, Maurice Henri (1942). “Energy, Quanta, and Vision”. Journal of General Physiology 25 (6):  819–840. doi:10.1085/jgp.25.6.819. PMC 2142545. PMID 19873316. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142545/.
Barlow, H.B.; Levick, W.R.; Yoon, M. (1971). “Responses to single quanta of light in retinal ganglion cells of the cat”. Vision Research 11 (Supplement 3):  87–101. doi:10.1016/0042-6989(71)90033-2. PMID 5293890.
Venter, J. Craig; Remington, K; Heidelberg, JF; Halpern, AL; Rusch, D; Eisen, JA; Wu, D; Paulsen, I et al. (2004). “Environmental Genome Shotgun Sequencing of the Sargasso Sea”. Science 304 (5667):  66–74. Bibcode: 2004Sci...304...66V. doi:10.1126/science.1093857. PMID 15001713.  The oceans are full of type 1 rhodopsin.
Waschuk, Stephen A.; Bezerra, Arandi G.; Shi, Lichi; Brown, Leonid S. (2005). “Leptosphaeria rhodopsin: Bacteriorhodopsin-like proton pump from a eukaryote”. Proceedings of the National Academy of Sciences 102 (19):  6879–6883. Bibcode: 2005PNAS..102.6879W. doi:10.1073/pnas.0409659102. PMC 1100770. PMID 15860584. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1100770/.
Su, Chih-Ying; Luo, Dong-Gen; Terakita, Akihisa; Shichida, Yoshinori; Liao, Hsi-Wen; Kazmi, Manija A.; Sakmar, Thomas P.; Yau, King-Wai (2006). “Parietal-Eye Phototransduction Components and Their Potential Evolutionary Implications”. Science 311 (5767):  1617–1621. Bibcode: 2006Sci...311.1617S. doi:10.1126/science.1123802. PMID 16543463. https://semanticscholar.org/paper/88b6bd3e5e59d46128d53a1bbe8b2b4b7d5229e6.
Luo, Dong-Gen; Xue, Tian; Yau, King-Wai (2008). “How vision begins: An odyssey”. Proceedings of the National Academy of Sciences 105 (29):  9855–9862. Bibcode: 2008PNAS..105.9855L. doi:10.1073/pnas.0708405105. PMC 2481352. PMID 18632568. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481352/.  Good historical review.
Schäfer, Günter; Engelhard, Martin; Müller, Volker (1999). “Bioenergetics of the Archaea”. Microbiology and Molecular Biology Reviews 63 (3):  570–620. doi:10.1128/MMBR.63.3.570-620.1999. PMC 103747. PMID 10477309. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC103747/.
Fan, Jie; Woodruff, Michael L; Cilluffo, Marianne C; Crouch, Rosalie K; Fain, Gordon L (2005). “Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice”. Journal of Physiology 568 (1):  83–95. doi:10.1113/jphysiol.2005.091942. PMC 1474752. PMID 15994181. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474752/.
Sadekar, Sumedha; Raymond, Jason; Blankenship, Robert E. (2006). “Conservation of Distantly Related Membrane Proteins: Photosynthetic Reaction Centers Share a Common Structural Core”. Molecular Biology and Evolution 23 (11):  2001–2007. doi:10.1093/molbev/msl079. PMID 16887904.
Yokoyama, Shozo; Radlwimmer, F. Bernhard (2001). “The molecular genetics and evolution of red and green color vision in vertebrates”. Genetics 158 (4):  1697–1710. PMC 1461741. PMID 11545071. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461741/.
Racker, Efraim; Stoeckenius, Walther (1974). “Reconstitution of Purple Membrane Vesicles Catalyzing Light-driven Proton Uptake and Adenosine Triphosphate Formation”. Journal of Biological Chemistry 249 (2):  662–663. doi:10.1016/S0021-9258(19)43080-9. PMID 4272126.
Kawaguchi, Riki; Yu, Jiamei; Honda, Jane; Hu, Jane; Whitelegge, Julian; Ping, Peipei; Wiita, Patrick; Bok, Dean et al. (2007). “A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A”. Science 315 (5813):  820–825. Bibcode: 2007Sci...315..820K. doi:10.1126/science.1136244. PMID 17255476.
Amora, Tabitha L.; Ramos, Lavoisier S.; Galan, Jhenny F.; Birge, Robert R. (2008). “Spectral Tuning of Deep Red Cone Pigments”. Biochemistry 47 (16):  4614–20. doi:10.1021/bi702069d. PMC 2492582. PMID 18370404. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492582/.
Send, Robert; Sundholm, Dage (2007). “Stairway to the conical intersection: A computational study of retinal isomerization”. Journal of Physical Chemistry A 111 (36):  8766–8773. Bibcode: 2007JPCA..111.8766S. doi:10.1021/jp073908l. PMID 17713894.
Salom, David; Lodowski, David T.; Stenkamp, Ronald E.; Le Trong, Isolde; Golczak, Marcin; Jastrzebska, Beata; Harris, Tim; Ballesteros, Juan A. et al. (2006). “Crystal structure of a photoactivated deprotonated intermediate of rhodopsin”. Proceedings of the National Academy of Sciences 103 (44):  16123–16128. Bibcode: 2006PNAS..10316123S. doi:10.1073/pnas.0608022103. PMC 1637547. PMID 17060607. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637547/.
オプシンタンパク質は、レチナールの分子を囲み、光子の検出を待つ。レチナールが光子を捕獲するとレチナールの構造変化が周囲のオプシンタンパク質に押し付けられる。オプシンは光が検出されたことを示す化学信号をヒトの脳に送ることができる。その後、レチナールはATPのリン酸化により11-シスの構成に戻され、このサイクルが再び始まる。
動物のGPCRロドプシン（虹色）が脂質二重層（頭部が赤、尾部が青）に埋め込まれ、その下にトランスデューシン（英語版）（Gt）がある。Gtαは赤、Gtβは青、 Gtγは黄に着色されている。Gtαサブユニットには、GDP分子が、ロドプシンにはレチナール（黒）が結合している。ロドプシンのN末端は赤、C末端は青である。トランスデューシンの膜への固定は黒で描かれている。
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