LIG1
関連文献

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“[Paralysis following Dimer X radiculography]”. La Nouvelle Presse Médicale 5 (17):  1120–2. (1976). PMID 934827.
“Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene.”. Lancet 339 (8808):  1508–9. (1992). doi:10.1016/0140-6736(92)91266-B. PMID 1351188.
“Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.”. Cell 69 (3):  495–503. (1992). doi:10.1016/0092-8674(92)90450-Q. PMID 1581963.
“Assignment of the gene encoding DNA ligase I to human chromosome 19q13.2-13.3.”. Genomics 12 (1):  164–6. (1992). doi:10.1016/0888-7543(92)90422-O. PMID 1733856. https://zenodo.org/record/1258593.
“A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells.”. Proc. Natl. Acad. Sci. U.S.A. 88 (17):  7615–9. (1991). doi:10.1073/pnas.88.17.7615. PMC 52352. PMID 1881902. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52352/.
“Mammalian DNA ligases. Biosynthesis and intracellular localization of DNA ligase I.”. J. Biol. Chem. 265 (21):  12618–22. (1990). PMID 2197279.
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“The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication.”. EMBO J. 14 (21):  5379–86. (1996). doi:10.1002/j.1460-2075.1995.tb00222.x. PMC 394647. PMID 7489727. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC394647/.
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“Isolation and characterization of the human MRE11 homologue.”. Genomics 29 (1):  80–6. (1996). doi:10.1006/geno.1995.1217. PMID 8530104.
“DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability.”. Nat. Genet. 13 (4):  489–91. (1996). doi:10.1038/ng0896-489. PMID 8696349.
“Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene 200 (1–2):  149–56. (1997). doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
“The replication factory targeting sequence/PCNA-binding site is required in G(1) to control the phosphorylation status of DNA ligase I.”. EMBO J. 18 (20):  5745–54. (1999). doi:10.1093/emboj/18.20.5745. PMC 1171641. PMID 10523317. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171641/.
“Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.”. J. Biol. Chem. 274 (47):  33703–8. (1999). doi:10.1074/jbc.274.47.33703. PMID 10559261.
“DNA repair patch-mediated double strand DNA break formation in human cells.”. J. Biol. Chem. 275 (35):  27386–92. (2000). doi:10.1074/jbc.M003126200. PMID 10827190.
ニックを持つDNAを修復しているDNAリガーゼI
DNAリガーゼIの構造の模式図
DNAリガーゼによるニックシーリングの機構
塩基除去修復の2つの経路