チオレドキシン
脚注・参考文献

1 2 3  GRCh38: Ensembl release 89: ENSG00000136810 - Ensembl, May 2017
1 2 3  GRCm38: Ensembl release 89: ENSMUSG00000028367 - Ensembl, May 2017
↑  Human PubMed Reference:
↑  Mouse PubMed Reference:
↑  Wollman EE, d'Auriol L, Rimsky L, Shaw A, Jacquot JP, Wingfield P, Graber P, Dessarps F, Robin P, Galibert F (October 1988). “Cloning and expression of a cDNA for human thioredoxin”. J. Biol. Chem. 263 (30):  15506–12. PMID 3170595.
↑  Holmgren A (1989). “Thioredoxin and glutaredoxin systems”. J Biol Chem 264 (24):  13963–6. PMID 2668278. http://www.jbc.org/cgi/reprint/264/24/13963.pdf.
↑  Nordberg J, Arnér E (2001). “Reactive oxygen species, antioxidants, and the mammalian thioredoxin system”. Free Radic Biol Med 31 (11):  1287–312. doi:10.1016/S0891-5849(01)00724-9. PMID 11728801.
↑  Meng, Ling; Wong, Joshua; Feldman, Lewis; Lemaux, Peggy; Buchanan, Bob (2010). “A membrane-associated thioredoxin required for plant growth moves from cell to cell, suggestive of a role in intercellular communication”. Proceedings of the National Academy of Sciences of the USA 107 (8):  3900–5. doi:10.1073/pnas.0913759107. PMC 2840455. PMID 20133584. http://www.pnas.org/content/107/8/3900.short?related-urls=yes&legid=pnas;107/8/3900.
↑  Mustacich D, Powis G (February 2000). “Thioredoxin reductase”. Biochem J 346 (Pt 1):  1–8. doi:10.1042/0264-6021:3460001. PMC 1220815. PMID 10657232. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220815/.
↑  Arnér E, Holmgren A (2000). “Physiological functions of thioredoxin and thioredoxin reductase”. Eur J Biochem 267 (20):  6102–9. doi:10.1046/j.1432-1327.2000.01701.x. PMID 11012661.
↑  Nishiyama, A; Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul. 1999). “Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression”. J. Biol. Chem. (UNITED STATES) 274 (31):  21645–50. doi:10.1074/jbc.274.31.21645. ISSN 0021-9258. PMID 10419473.
↑  Liu, Yingmei; Min Wang (Jun. 2002). “Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner”. Circ. Res. (United States) 90 (12):  1259–66. doi:10.1161/01.RES.0000022160.64355.62. PMID 12089063.
↑  Morita, K; Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov. 2001). “Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress”. EMBO J. (England) 20 (21):  6028–36. doi:10.1093/emboj/20.21.6028. ISSN 0261-4189. PMC 125685. PMID 11689443. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125685/.
↑  Saitoh, M; Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H (May. 1998). “Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1”. EMBO J. (ENGLAND) 17 (9):  2596–606. doi:10.1093/emboj/17.9.2596. ISSN 0261-4189. PMC 1170601. PMID 9564042. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170601/.
↑  Matsumoto, Ken; Masutani Hiroshi, Nishiyama Akira, Hashimoto Shu, Gon Yasuhiro, Horie Takashi, Yodoi Junji (Jul. 2002). “C-propeptide region of human pro alpha 1 type 1 collagen interacts with thioredoxin”. Biochem. Biophys. Res. Commun. (United States) 295 (3):  663–7. doi:10.1016/S0006-291X(02)00727-1. ISSN 0006-291X. PMID 12099690.
↑  Makino, Y; Yoshikawa N, Okamoto K, Hirota K, Yodoi J, Makino I, Tanaka H (Jan. 1999). “Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function”. J. Biol. Chem. (UNITED STATES) 274 (5):  3182–8. doi:10.1074/jbc.274.5.3182. ISSN 0021-9258. PMID 9915858.
酸化還元サイクルの概念図
TrxR:チオレドキシン・ジスルフィド還元酵素
FAD:フラボタンパク質
S2:ジスルフィド結合
Se:セレニウム
Trx-S2:チオレドキシンジスルフィド
Trx-(SH)2:チオレドキシン
Protein:タンパク質等