NUMB (タンパク質)
関連文献

“A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution”. Proc. Natl. Acad. Sci. U.S.A. 92 (21):  9530–4. (1995). Bibcode: 1995PNAS...92.9530W. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40835/.
“Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease”. Nature 375 (6534):  754–60. (1995). Bibcode: 1995Natur.375..754S. doi:10.1038/375754a0. PMID 7596406.
“Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis”. Neuron 17 (1):  43–53. (1996). doi:10.1016/S0896-6273(00)80279-2. PMID 8755477.
“Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module”. Genes Dev. 11 (17):  2239–49. (1997). doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC275390/.
“The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX”. J. Biol. Chem. 273 (15):  9179–87. (1998). doi:10.1074/jbc.273.15.9179. PMID 9535908.
“The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb”. Mol. Cell. Biol. 18 (7):  3974–82. (1998). doi:10.1128/MCB.18.7.3974. PMC 108982. PMID 9632782. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108982/.
“Numb Is an Endocytic Protein”. J. Cell Biol. 151 (6):  1345–52. (2001). doi:10.1083/jcb.151.6.1345. PMC 2190585. PMID 11121447. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190585/.
“Siah-1 binds and regulates the function of Numb”. Proc. Natl. Acad. Sci. U.S.A. 98 (26):  15067–72. (2002). Bibcode: 2001PNAS...9815067S. doi:10.1073/pnas.261571998. PMC 64984. PMID 11752454. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64984/.
“LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation”. EMBO J. 21 (1–2):  93–102. (2002). doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125803/.
“The Lnx family proteins function as molecular scaffolds for Numb family proteins”. Mol. Cell. Neurosci. 18 (5):  525–40. (2002). doi:10.1006/mcne.2001.1024. PMID 11922143.
“The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling”. Proc. Natl. Acad. Sci. U.S.A. 99 (10):  7102–7. (2002). Bibcode: 2002PNAS...99.7102R. doi:10.1073/pnas.102192599. PMC 124535. PMID 12011466. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124535/.
“Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26):  16899–903. (2003). Bibcode: 2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
“Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling”. Proc. Natl. Acad. Sci. U.S.A. 100 (5):  2272–7. (2003). Bibcode: 2003PNAS..100.2272C. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151330/.
“Mammalian Numb is a target protein of Mdm2, ubiquitin ligase”. Biochem. Biophys. Res. Commun. 302 (4):  869–72. (2003). doi:10.1016/S0006-291X(03)00282-1. PMID 12646252.
“Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain”. J. Biol. Chem. 278 (25):  23196–203. (2003). doi:10.1074/jbc.M302827200. PMID 12682059.
“RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis”. J. Biol. Chem. 278 (33):  30597–604. (2003). doi:10.1074/jbc.M302191200. PMID 12775724.
“CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth”. Nat. Cell Biol. 5 (9):  819–26. (2003). doi:10.1038/ncb1039. PMID 12942088.
“A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division”. J. Biol. Chem. 279 (12):  11304–12. (2004). doi:10.1074/jbc.M311733200. PMID 14670962.
“Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1):  40–5. (2004). doi:10.1038/ng1285. PMID 14702039.