小林哲郎
主な発表論文

Kobayashi T, Sawano S, Itoh T, Sugimoto T, Takahashi S, Tanaka T, Suwa S :  Islet-cell antibodies in Insulin-dependent and non-insulin dependent diabetics in Japan : their prevalence and clinical significance. Clinico-genetic genesis of diabetes mellitus. Mimura G, Baba S, Goto Y, Kobberling J, Eds. Amsterdam, Excerpta Med p.150-160, 1982 (ICS No. 597)
Kobayashi T, Sugimoto T, Itoh T, Kosaka K, Tanaka T, Suwa S, Satoh K, Tsuji K: The prevalence of islet cell antibodies in Japanese insulin-dependent and non-insulin-dependent diabetic patients studied by indirect immunofluorescence and by a new method. Diabetes 35 : 335-340, 1986
Kobayashi T, Itoh T, Kosaka K, Sato K, Tsuji K: Time course of islet cell antibodies and beta-cell function in non-insulin-dependent stage of type 1 diabetes. Diabetes 36 : 510-517, 1987
Kobayashi T, Nakanishi K, Sugimoto T, Itoh T, Murase T, Kosaka K, Tsuji K:  Maleness as risk factor for slowly progressive IDDM. Diabetes Care 12 : 7-11, 1989
Kobayashi T: Immunology and Immunogenetics of type I diabetes in Japan. IDF Bulletin 35 : 34-37, 1990
Kobayashi T, Tamemoto K, Nakanishi K, Kato N, Okubo M, Kajio H, Sugimoto T, Murase T, Kosaka K: Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care 16 : 780-788, 1993
Oka Y, Katagiri H, Yazaki Y, Murase T, Kobayashi T: Mitochondria gene mutation in islet-cell-antibody-positive patients who were initially non-insulin-dependent diabetics. Lancet 342 : 527-528, 1993
Nakanishi K, Kobayashi T, Miyashita H, Okubo M, Sugimoto T, Murase T, Hashimoto M, Fukuchi S, Kosaka K: Exocrine pancreatic ductgrams in insulin-dependent diabetes mellitus. Am J Gastroenterol 89 : 762-766, 1994
Kobayashi T: Subtype of insulin-dependent diabetes mellitus (IDDM) in Japan : slowly progressive IDDM-the clinical characteristics and pathogenesis of the syndrome. Diabetes Res Clin Pract 24 (Suppl) : S95-S99, 1994
Kobayashi T, Nakanishi K, Murase T, Kosaka K: Small doses of subcutaneous insulin as a strategy for preventing slowly progressive -cell failure in islet cell antibody-positive patients with clinical features of NIDDM.Diabetes 45 : 622-626, 1996
Kobayashi T, Nakanishi K, Okubo M, Murase T, Kosaka K: GAD antibodies seldom disappear in slowly progressive IDDM. Diabetes Care 19: 1031, 1996
Tanaka S, Kobayashi T, Momotsu T: A novel subtype of Type 1 diabetes mellitus. N Engl J Med 342 : 1835-1837, 2000
Tanaka S, Kobayashi T, Nakanishi K, Okubo M, Murase T, Hashimoto M,  Takeuchi K: Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis. Lancet 356 : 910-911, 2000
Kobayashi T, Tanaka S, Okubo M, Nakanishi K, Murase T, Lernmark Å: Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes. J Clin Endocrinol Metab 88 : 4768-4775, 2003
Tanaka S, Endo T, Aida K, Shimura H, Yokomori N, Kaneshige M, Furuya F, Amemiya S, Mochizuki M, Nakanishi K, Kobayashi T: Distinct diagnostic criteria of fulminant type 1 diabetes based on serum C-peptide response and HbA1c levels at onset. Diabetes Care 27: 1936-1941, 2004
Maruyama T, Tanaka S, Shimada A, Funae O, Kasuga A, Kanatsuka A, Takei I, Yamada S, Harii N, Shimura H, Kobayashi T: Insulin intervention in slowly progressive insulin- dependent (type 1) diabetes mellitus. J Clin Endocrinol Metab 93: 2115-2121, 2008
Endo T, Takizawa S, Tanaka S, Takahashi M, Fujii H, Kamisawa T, Kobayashi T: Amylase α-2A autoantibodies :  Novel marker of autoimmune pancreatitis and fulminant type 1 diabetes. Diabetes 58: 732-737, 2009
Tanaka S, Nishida Y, Aida K, Maruyama T, Shimada A, Suzuki M, Shimura H, Takizawa S, Takahashi M, Akiyama D, Arai-Yamashita S, Furuya F, Kawaguchi A, Kaneshige M, Katoh R, Endo T, Kobayashi T: Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: A mechanism of accelerated -cell failure in fulminant type 1 diabetes. Diabetes 58 : 2285-2291, 2009
Aida K, Nishida Y, Tanaka S, Maruyama T, Shimada A, Awata T, Suzuki M, Shimura H, Takizawa S, Ichijo M, Akiyama D, Furuya F, Kawaguchi A, Kaneshige M, Itakura J, Fujii H, Endo T, Kobayashi T :  RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates T-cell death in fulminant type 1 diabetes. Diabetes 60: 884-889, 2011
Furuya F, Shimura H, Asami K, Ichijo S, Takahashi K, Kaneshige M, Oikawa Y, Aida K, Endo T, Kobayashi T : Ligand-bound thyroid hormone receptor contributes to reprogramming of pancreatic acinar cells into insulin-producing cells. J Biol Chem 288 : 16155-16166, 2013
Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T: Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of regenerating gene (REG) protein in fulminant type 1 diabetes. PLoS ONE 9: e95110, 2014.
Nishida Y, Aida K, Kihara M, Kobayashi T. Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry. PLoS ONE 9: e107664, 2014.
Tanaka S, Ohmori M, Awata T, Simada A, Mrrao S, Maruyama T, Kamoi K, Kawasaki E, Nakanishi K, Nagata M, Fujii S, Ikegami H, Imagawa A, Uchigata Y, Okubo M, Osawa H, Kajio H, Kawaguchi A, Kawabata Y, Satoh J, Shimizu I, Takahashi K, Makino H, Iwahashi H, Mirra J, Yasuda K, Hanafusa T, Kobayashi T, Committee on Type 1 Diabetes. Diagnostic criteria for slowly progressive insulin-dependent (type 1) diabetes ellitus (SPIDDM) (2012): report by the Committee on Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus of the Japan Diabetes Society. Diabetol Int 6: 1-7, 2015.
Kobayashi T, Aida K, Fukui T, Jimbo E, Shimada A, Mori Y, Fujii T, Yagihashi S. Pancreatic ductal hyperplasia/dysplasia with obstructive chronic pancreatitis: an association with reduced pancreatic weight in type 1 diabetes. Diabetologia 59: 865-867, 2016.
Tanaka S, Okubo M, Nagasawa K, Takizawa S, Ichijo M, Ichijo S, Kaneshige M, Aida K, Shimura H, Mori Y, Kobayashi T. Predictive value of titer of GAD antibodies for further progression of beta cell dysfunction in slowly progressive insulin-dependent (type 1) diabetes (SPIDDM). Diabetol Int 7: 42–52, 2016.
Awata T, Shimada A, Maruyama T, Oikawa Y, Yasukawa N, Kurihara S, Miyashita Y, Hatano M, Ikegami Y, Matsuda M, Niwa M, Kazama Y, Tanaka S, Kobayashi T. Possible long-term efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, for slowly progressive type 1 diabetes (SPIDDM) in the stage of non-insulin-dependency: an open-label randomized controlled pilot trial (SPAN-S). Diabetes Ther 8:1123–1134, 2017.
Aida K, Kobayashi T, Takeshita A, Jimbo E, Nishida Y, Yagihashi S, Hosoi M, Fukui T, Sugawara A, Takasawa S. Crucial role Reg 1 from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice. Biochem Biophys Res Commu 503(2): 963-969, 2018.
Aida K, Fukui T, Jimbo E, Yagihashi S, Shimada A, Oikawa Y, Mori Y, Fujii T, Nishida Y, Koyama R, Kobayashi T. Distinct Inflammatory Changes of the Pancreas of Slowly Progressive Insulin-dependent (Type 1) Diabetes. Pancreas 47(9): 1101-1109, 2018.