EZH2
関連文献

“The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer”. Journal of Molecular Histology 37 (5–7):  219–23. (Sep 2006). doi:10.1007/s10735-006-9042-9. PMID 16855786.
“Epigenetic control of hematopoietic stem cell aging the case of Ezh2”. Annals of the New York Academy of Sciences 1106 (1):  233–9. (Jun 2007). doi:10.1196/annals.1392.008. PMID 17332078.
“Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression”. Molecular and Cellular Biology 16 (6):  3066–73. (Jun 1996). doi:10.1128/MCB.16.6.3066. PMC 231301. PMID 8649418. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231301/.
“Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Research 6 (9):  791–806. (Sep 1996). doi:10.1101/gr.6.9.791. PMID 8889548.
“Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1”. Genomics 37 (2):  161–71. (Oct 1996). doi:10.1006/geno.1996.0537. PMID 8921387.
“Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres”. The EMBO Journal 16 (11):  3219–32. (Jun 1997). doi:10.1093/emboj/16.11.3219. PMC 1169939. PMID 9214638. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1169939/.
“Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein”. Human Molecular Genetics 7 (4):  679–84. (Apr 1998). doi:10.1093/hmg/7.4.679. PMID 9499421.
“Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes”. Molecular and Cellular Biology 18 (6):  3572–9. (Jun 1998). doi:10.1128/MCB.18.6.3572. PMC 108938. PMID 9584197. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108938/.
“Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes”. Molecular and Cellular Biology 18 (6):  3586–95. (Jun 1998). doi:10.1128/mcb.18.6.3586. PMC 108940. PMID 9584199. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108940/.
“Point mutations in the WD40 domain of Eed block its interaction with Ezh2”. Molecular and Cellular Biology 18 (10):  5634–42. (Oct 1998). doi:10.1128/MCB.18.10.5634. PMC 109149. PMID 9742080. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109149/.
“Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation”. Nature Genetics 23 (4):  474–8. (Dec 1999). doi:10.1038/70602. PMID 10581039.
“The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders”. European Journal of Human Genetics 8 (3):  174–80. (Mar 2000). doi:10.1038/sj.ejhg.5200439. PMID 10780782.
“Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation”. Journal of Immunology 166 (10):  5925–34. (May 2001). doi:10.4049/jimmunol.166.10.5925. PMID 11342607.
“Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein”. The Journal of Biological Chemistry 276 (46):  43065–73. (Nov 2001). doi:10.1074/jbc.M104294200. PMID 11571280.
“The polycomb group protein EZH2 is involved in progression of prostate cancer”. Nature 419 (6907):  624–9. (Oct 2002). doi:10.1038/nature01075. hdl:2027.42/62896. PMID 12374981. https://deepblue.lib.umich.edu/bitstream/2027.42/62896/1/nature01075.pdf.
“EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells”. Proceedings of the National Academy of Sciences of the United States of America 100 (20):  11606–11. (Sep 2003). doi:10.1073/pnas.1933744100. PMC 208805. PMID 14500907. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC208805/.
リジンの末端のアンモニウム基は最大3回メチル化される。
EZH2（黄、PDB: 4MI0​）とヒトSET7/9（シアン、PDB: 1O9S​）のSETドメインのSTAMPアラインメント。結合したSAMが赤、リジンが青で示されている。
EZH2（黄、PDB: 4MI0​）とヒトSET7/9（シアン、PDB: 1O9S​）の活性部位残基のSTAMPアラインメント
EZH2の推定触媒機構
EZH2の阻害剤。a ; b ; c ; d ; e ; f;
EZH2のホモログの遺伝子系統樹。この系統樹はEnsembl（英語版）データベース中の587のEZH2遺伝子とその生物種を用いて作成されている。