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| タイトル | 年 | 最高チャート順位> US | 最高チャート順位> US Dance | 最高チャート順位> AUS | 最高チャート順位> AUT | 最高チャート順位> BEL(FL) | 最高チャート順位> CAN | 最高チャート順位> FRA | 最高チャート順位> NZ | 最高チャート順位> SWE | 最高チャート順位> UK | 認定 | アルバム |
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| "Weekends" (featuring Sirah) | 2010 | — | — | — | — | — | 93 | — | — | — | — |  RIAA: Gold  MC: Gold | My Name is Skrillex |
| "Scary Monsters and Nice Sprites" | 2010 | 69 | — | 56 | — | — | 66 | 71 | — | 20 | 143 |  RIAA: 2× Platinum  ARIA: 2× Platinum  GLF: 2× Platinum  MC: Platinum | Scary Monsters and Nice Sprites |
| "First of the Year (Equinox)" | 2011 | 85 | — | 84 | — | — | 88 | 187 | — | 19 | — |  RIAA: Platinum  GLF: 2× Platinum  MC: Gold | More Monsters and Sprites |
| "Ruffneck (Full Flex)" | 2011 | — | — | — | — | — | — | — | — | — | 89 |  | More Monsters and Sprites |
| "Breakn' a Sweat" | 2012 | — | — | — | — | — | 80 | — | — | — | 32 |  | Bangarang |
| "Bangarang" (featuring Sirah) | 2012 | 72 | — | 4 | 25 | 9 | 26 | 63 | 14 | 24 | 24 |  RIAA: 3× Platinum  ARIA: 7× Platinum  BEA: Gold  BPI: Platinum  GLF: Platinum  IFPI AUT: Platinum  MC: Platinum | Bangarang |
| "Lick It" (with カスケイド) | 2012 | — | — | — | — | — | — | — | — | — | — |  | Fire & Ice |
| "Make It Bun Dem" (with Damian "Jr. Gong" Marley) | 2012 | — | — | 27 | 34 | 15 | 34 | 87 | 16 | 48 | 58 |  RIAA: Platinum  ARIA: 2× Platinum  BPI: Silver  GLF: Platinum  MC: Gold | Make It Bun Dem After Hours EP |
| "Try It Out" (with Alvin Risk) | 2013 | — | 19 | — | — | — | — | 185 | — | — | — |  | Recess |
| "Ragga Bomb" (featuring Ragga Twins) | 2014 | — | 16 | — | — | — | — | — | — | — | — |  | Recess |
| "Recess" (with Kill the Noise featuring Fatman Scoop and Michael Angelakos) | 2014 | — | 13 | 47 | 69 | — | 59 | 189 | — | — | 57 |  | Recess |
| "Dirty Vibe" (with ディプロ featuring G-DRAGON and CL) | 2014 | — | 15 | — | — | — | — | — | — | — | — |  | Recess |
| "Burial" (with Yogi featuring Pusha T, Moody Good and TrollPhace) | 2015 | — | 23 | — | — | — | — | — | — | — | 90 |  | Non-album single |
| "Bun Up the Dance" (with ディロン・フランシス) | 2015 | — | 32 | — | — | — | — | — | — | — | — |  | This Mixtape Is Fire |
| "Squad Out!" (with Jauz featuring Fatman Scoop) | 2015 | — | — | — | — | — | — | — | — | — | — |  | Adult Swim Singles 2015 |
| "Working for It" (with Zhu and THEY.) | 2015 | — | 11 | 30 | — | — | — | 122 | 39 | — | 71 |  ARIA: Platinum | Genesis Series |
| "El Chapo" (with The Game) | 2015 | — | — | — | — | — | — | — | — | — | — |  RIAA: Gold | The Documentary 2.5 |
| "VIP's" (with Must Die!) | 2016 | — | — | — | — | — | — | — | — | — | — |  | OWSLA Worldwide Broadcast |
| "Pretty Bye Bye" (with Team EZY featuring NJOMZA) | 2016 | — | — | — | — | — | — | — | — | — | — |  | OWSLA Worldwide Broadcast |
| "No Chill" (with Vic Mensa) | 2016 | — | — | — | — | — | — | — | — | — | — |  | Traffic |
| "Killa" (with Wiwek featuring Elliphant) | 2016 | — | — | — | — | — | — | — | — | — | — |  | The Free & Rebellious |
| "Purple Lamborghini" (with リック・ロス) | 2016 | 33 | 6 | 39 | 56 | — | 28 | 58 | 34 | — | 61 |  RIAA: Platinum  ARIA: 2× Platinum  BPI: Silver  MC: Gold | Suicide Squad: The Album |
| "Slam Dunk" (with Valentino Khan featuring Kstylis) | 2016 | — | — | — | — | — | — | — | — | — | — |  | Non-album singles |
| "Waiting" (with RL Grime and What So Not) | 2016 | — | — | — | — | — | — | — | — | — | — |  | Non-album singles |
| "Chicken Soup" (with Habstrakt) | 2017 | — | — | — | — | — | — | — | — | — | — |  | HOWSLA |
| "Would You Ever" (with Poo Bear) | 2017 | — | 16 | 42 | — | — | 61 | — | — | 91 | 55 |  RIAA: Gold  ARIA: 2× Platinum  MC: Gold  BPI: Silver | Non-album singles |
| "Saint Laurent"  (with DJ Sliink and Wale) | 2017 | — | — | — | — | — | — | — | — | — | — |  | Non-album singles |
| "Favor"  (with Vindata and Nstasia) | 2017 | — | — | — | — | — | — | — | — | — | — |  | Non-album singles |
| "Humble (Skrillex remix)"  (with ケンドリック・ラマー) | 2017 | — | — | — | — | — | — | — | — | — | — |  ARIA: 13× Platinum | Non-album singles |
| "Goh" (with What So Not featuring KLP) | 2018 | — | — | — | — | — | — | — | — | — | — |  | Not All the Beautiful Things |
| "Agen Wida" (with Joyryde) | 2018 | — | 35 | — | — | — | — | — | — | — | — |  | Non-album single |
| "Face My Fears" (with 宇多田ヒカル) | 2019 | 98 | 9 | — | — | — | — | — | — | — | — |  | Bad Mode |
| "Two Nights Part II" (Remix)  (with Lykke Li and Ty Dolla Sign) | 2019 | — | — | — | — | — | — | — | — | — | — |  | Still Sad Still Sexy |
| "Midnight Hour" (with ボーイズ・ノイズ and Ty Dolla Sign) | 2019 | — | 17 | — | — | — | — | — | — | — | — |  |  |
| "Butterflies" (with Starrah and フォー・テット) | 2021 | — | 16 | — | — | — | — | — | — | — | — |  | Quest for Fire |
| "Too Bizarre" (with Swae Lee and Siiickbrain) | 2021 | — | 36 | — | — | — | — | — | — | — | — |  | Quest for Fire |
| "Supersonic (My Existence)" (with Noisia, Josh Pan and Dylan Brady) | 2021 | — | 13 | — | — | — | — | — | — | — | — |  | Quest for Fire |
| "En Mi Cuarto" (with Jhay Cortez) | 2021 | — | 8 | — | — | — | — | — | — | — | — |  RIAA: 2× Platinum (Latin) | Timelezz |
| "In da Getto" (with J Balvin) | 2021 | 90 | 2 | — | — | — | 87 | — | — | — | — |  | Jose |
| "Don't Go" (with ジャスティン・ビーバー and Don Toliver) | 2021 | 69 | 43 | — | — | — | — | — | 67 | — | 56 |  | Don't Get Too Close |
| "Rumble" (with Fred Again and Flowdan) | 2023 | — | 10 | 32 | — | — | 80 | — | 21 | 73 | 19 |  | Quest for Fire |
| "Way Back" (with PinkPantheress and トリッピー・レッド) | 2023 | — | 13 | — | — | — | — | — | — | — | — |  | Don't Get Too Close |
| "Leave Me Like This" (with Bobby Raps) | 2023 | — | 15 | — | — | — | — | — | — | — | — |  | Quest for Fire |
| "Real Spring" (with Bladee) | 2023 | — | 20 | — | — | — | — | — | — | — | — |  | Don't Get Too Close |
| "Xena" (with Nai Barghouti) | 2023 | — | 21 | — | — | — | — | — | — | — | — |  | Quest for Fire |
| "Don't Get Too Close" (with Bibi Bourelly) | 2023 | — | — | — | — | — | — | — | — | — | — |  | Don't Get Too Close |
| "Baby Again" (with Fred Again and フォー・テット) | 2023 | — | 11 | 70 | — | — | — | — | — | — | 52 |  |  |
| "Fine Day Anthem" (with ボーイズ・ノイズ and Opus III) | 2023 | — | 21 | — | — | — | — | — | — | — | — |  |  |
| "Badders" (with Peekaboo, Flowdan, and G-Rex) | 2023 | — | 32 | — | — | — | — | — | — | — | — |  | Eyes Wide Open |
| "Taka" (with Ahadadream and Priya Ragu) | 2024 | — | 37 | — | — | — | — | — | — | — | — |  |  |
| "Push" (with Taichu, Hamdi, and Offaiah) | 2024 | — | 27 | — | — | — | — | — | — | — | — |  |  |
| "Talk to Me" (with Champion and フォー・テット featuring Naisha) | 2024 | — | 49 | — | — | — | — | — | — | — | — |  |  |
| "Heavy Heart" (with Loco Dice and Fireboy DML) | 2024 | — | — | — | — | — | — | — | — | — | — |  |  |