上田実 (医学研究者)
研究業績 > 主な原著論文

Wadagaki R, Mizuno D, Yamawaki-Ogata A, Satake M, Kaneko H, Hagiwara S, Yamamoto N, Narita Y, Hibi H, Ueda M.Osteogenic induction of bone marrow-derived stromal cells on simvastatin-releasing, biodegradable, nano- to microscale ﬁber scaffolds.Ann Biomed Eng. 39: 1872-81, 2011
Fujio M, Yamamoto A, Ando Y, Shohara R, Kinoshita K, Kaneko T, Hibi H, Ueda M.Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors.Bone. 49: 693-700, 2011
Nishino Y, Yamada Y, Ebisawa K, Nakamura S, Okabe K, Umemura E, Hara K, Ueda M.Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and the possibility of novel cell therapy.Cytotherapy. 13: 598-605, 2011
Sato F, Oze I, Kawakita D, Yamamoto N, Ito H, Hosono S, Suzuki T, Kawase T, Furue H, Watanabe M, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Ueda M, Tajima K, Tanaka H, Matsuo K.Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population.Head Neck. 33: 1628-37, 2011
Okamoto Y, Tateishi H, Kinoshita K, Tsuchiya S, Hibi H, Ueda M.An experimental study of bone healing around the titanium screw implants in ovariectomized rats: enhancement of bone healing by bone marrow stromal cells transplantation.Implant Dent. 20: 236-45, 2011
Kohgo T, Yamada Y, Ito K, Yajima A, Yoshimi R, Okabe K, Baba S, Ueda M.Bone regeneration with self-assembling peptide nanofiber scaffolds in tissue engineering for osseointegration of dental implants.Int J Periodontics Restorative Dent. 31: e9-16, 2011
Hamamura K, Tsuji M, Hotta H, Ohkawa Y, Takahashi M, Shibuya H, Nakashima H, Yamauchi Y, Hashimoto N, Hattori H, Ueda M, Furukawa K.Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.J Biol Chem. 286: 18526-37, 2011
Nishino Y, Ebisawa K, Yamada Y, Okabe K, Kamei Y, Ueda M.Human deciduous teeth dental pulp cells with basic ﬁbroblast growth factor enhance wound healing of skin defect.J Craniofac Surg.22: 438-42, 2011
Hara K, Yamada Y, Nakamura S, Umemura E, Ito K, Ueda M.Potential characteristics of stem cells from human exfoliated deciduous teeth compared with bone marrow-derived mesenchymal stem cells for mineralized tissue-forming cell biology.J Endod. 37: 1647-52, 2011
Hibi H, Ueda M.Supraperiosteal transport distraction osteogenesis for reconstructing a segmental defect of the mandible. J Oral Maxillofac Surg. 69: 742-6, 2011
Matsumoto K, Yamamoto N, Hagiwara S, Saito M, Furue H, Shigetomi T, Narita Y, Mitsudo K, Tohnai I, Kobayashi T, Ueda M.Optimization of hyperthermia and dendritic cell immunotherapy for squamous cell carcinoma. Oncol Rep. 25: 1525-32, 2011
Sugiyama M, Iohara K, Wakita H, Hattori H, Ueda M, Matsushita K, Nakashima M.Dental pulp-derived CD31-/CD146- side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats.Tissue Eng Part A. 17: 1303-11, 2011
Umemura E, Yamada Y, Nakamura S, Ito K, Hara K, Ueda M.Viable cryopreserving tissue-engineered cell-biomaterial for cell banking therapy in an effective cryoprotectant.Tissue Eng Part C Methods. 17: 799-807, 2011
Shibuya H, Hamamura K, Hotta H, Matsumoto Y, Nishida Y, Hattori H, Furukawa K, Ueda M, Furukawa K. Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3. Cancer Sci. 103: 1656-64, 2012
（2012年〜）
Shohara R, Yamamoto A, Takikawa S, Iwase A, Hibi H, Kikkawa F, Ueda M.Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms.Cytotherapy. 14: 1171-81, 2012
Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.Glycoconj J. 30: 585-97, 2012
Sakai K, Yamamoto A, Matsubara K, Nakamura S, Naruse M, Yamagata M, Sakamoto K, Tauchi R, Wakao N,Imagama S, Hibi H, Kadomatsu K, Ishiguro N, Ueda M.Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. J Clin Invest. 122: 80-90, 2012
Hibi H, Ueda M.Interfaces of titanium implants and a vascularized osteocutaneous scapular graft revised with distraction osteogenesis.J Craniofac Surg. 23: 1549-50, 2012
Osugi M, Katagiri W, Yoshimi R, Inukai T, Hibi H, Ueda M.Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects.Tissue Eng Part A. 35: 1102-10, 2012
Inoue T, Sugiyama M, Hattori H, Wakita H, Wakabayashi T, Ueda M.Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhance recovery of focal cerebral ischemia in rats.Tissue Eng Part A. 19: 24-29, 2012
（2013年〜）
Inukai T, Katagiri W, Yoshimi R, Osugi M, Kawai T, Hibi H, Ueda M.Novel application of stem cell-derived factors for periodontal regeneration. Biochem Biophys Res Commun. 430: 763-8, 2013
Yamada Y, Nakamura S, Ueda M, Ito K.Osteotome technique with injectable tissue-engineered bone and simultaneous implant placement by cell therapy.Clin Oral Implants Res. 24: 468-74, 2013
Katagiri W, Osugi M, Kawai T, Ueda M.Novel cell-free regeneration of bone using stem cell-derived growth factors. Int J Oral Maxillofac Implants. 28: 1009-16, 2013
Tamari M, Nishino Y, Yamamoto N, Ueda M.Acceleration of wound healing with stem cell-derived growth factors. Int J Oral Maxillofac Implants. 28: e369-75, 2013
Tsuchiya S, Hara K, Ikeno M, Okamoto Y, Hibi H, Ueda M.Rat bone marrow stromal cell-conditioned medium promotes early osseointegration of titanium implants. Int J Oral Maxillofac Implants. 28: 1360-9, 2013
Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M.Effects of the permeability of shields with autologous bone grafts on bone augmentation. Int J Oral Maxillofac Implants. 28: e386-92, 2013
Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M.Effects of self-assembling peptide hydrogel scaffold on bone regeneration with recombinant human bone morphogenetic protein-2.Int J Oral Maxillofac Implants. 28: e283-9, 2013
Tateishi H, Okamoto Y, Kinoshita K, Hibi H, Ueda M.Effects of implant surface on bone healing around titanium screw implants in ovariectomized rats.Int J Oral Maxillofac Implants. 28: e252-9, 2013
Nishiguchi H, Mitsudo K, Yamamoto N, Tohnai I.Thermochemoradiotherapy using superselective intra-arterial infusionfor N3 cervical lymph node metastases of tongue cancer.J Cancer Res Ther. 9: 718-20, 2013
Yamada Y, Nakamura S, Ueda M, Ito K.Papilla regeneration by injectable stem cell therapy with regenerative medicine: long-term clinical prognosis.J Tissue Eng Regen Med. 27: 10.1002/term.1737., 2013
Yamagata M, Yamamoto A, Kako E, Kaneko N, Matsubara K, Sakai K, Sawamoto K, Ueda M.Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke. 44: 551-4, 2013
Sugiyama M, Hattori H, Inoue T, Wakita H, Hibi H, Ueda M.Stem cells from human exfoliated deciduous teeth enhance recovery from focal cerebral ischemia in rats. J Oral Maxillofac Surg Med Pathol. 24: 10.1016/j.ajoms.2013.04.014, 2013
Hagiwara S, Yamamoto N, Furue H, Sakakura H, Shigetomi T, Murakumo Y, Hibi H, Takahashi H, Ueda M.Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma.J Oral Maxillofac Surg Med Pathol. 25: 276–281, 2013
（2014年〜）
Ando Y, Matsubara K, Ishikawa J, Fujio M, Shohara R, Hibi H, Ueda M, Yamamoto A.Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms.Bone. 61: 82-90, 2014
Ueda M.A novel approach for skin rejuvenation by regenerative medicine: delivery of stem cell-derived growth factors through an iontophoretic system.Int J Oral Maxillofac Implants. 29: e59-65, 2014
Yamamoto A, Sakai K, Matsubara K, Kano F, Ueda M.Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury.Neurosci Res. 78: 16-20, 2014
Sakakura H, Murakumo Y, Mii S, Hagiwara S, Kato T, Asai M, Hoshino A, Yamamoto N, Sobue S, Ichihara M, Ueda M, Takahashi M.Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice. PLoS One. 9: 10.1371/journal.pone.0083385, 2014
Al-Sharabi N, Xue Y, Fujio M, Ueda M, Gjerde C, Mustafa K, Fristad I.Bone marrow stromal cell paracrine factors direct osteo/odontogenic differentiation of dental pulp cells.Tissue Eng Part A. 20(21-22): 3063-72, 2014
Hironaka K, Ozaki N, Hattori H, Nagamine K, Nakashima H, Ueda M, Sugiura Y.Involvement of glial activation in trigeminal ganglion in a rat model of lower gingival cancer pain.Nagoya J Med Sci. 76(3-4):323-32, 2014
（2015年〜）
Kawai T, Katagiri W, Osugi M, Sugimura Y, Hibi H, Ueda M.Secretomes from bone marrow-derived mesenchymal stromal cells enhance periodontal tissue regeneration.Cytotherapy. 17(4): 369-81, 2015
Ogata K, Katagiri W, Osugi M, Kawai T, Sugimura Y, Hibi H, Nakamura S, Ueda M.Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model.Bone. 74: 95-105, 2015
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A.Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.J Neurosci. 35(6):2452-64, 2015
Fujii H, Matsubara K, Sakai K, Ito M, Ohno K, Ueda M, Yamamoto A.Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats.Brain Res. 1613:59-72, 2015
Wakayama H, Hashimoto N, Matsushita Y, Matsubara K, Yamamoto N, Hasegawa Y, Ueda M, Yamamoto A.Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute lung injury in mice.Cytotherapy. 17(8):1119-29, 2015
Ichimura N, Shinjo K, An B, Shimizu Y, Yamao K, Ohka F, Katsushima K, Hatanaka A, Tojo M, Yamamoto E, Suzuki H, Ueda M, Kondo Y.Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer.Cancer Prev Res (Phila). 8(8):702-11, 2015
Omori M, Tsuchiya S, Hara K, Kuroda K, Hibi H, Okido M, Ueda M.A new application of cell-free bone regeneration: immobilizing stem cells from human exfoliated deciduous teeth-conditioned medium onto titanium implants using atmospheric pressure plasma treatment.Stem Cell Res Ther. 6:124, 2015
Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A.Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease.Behav Brain Res. 293:189-97, 2015
Tsuchiya S, Ohmori M, Hara K, Fujio M, Ikeno M, Hibi H, Ueda M.An Experimental Study on Guided Bone Regeneration Using a Polylactide-co-glycolide Membrane-Immobilized Conditioned Medium.Int J Oral Maxillofac Implants. 30(5):1175-86, 2015
Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y.Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic β-cell function.BMJ Open Diabetes Res Care. 3(1):e000128, 2015
Hattori Y, Kim H, Tsuboi N, Yamamoto A, Akiyama S, Shi Y, Katsuno T, Kosugi T, Ueda M, Matsuo S, Maruyama S.Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury.PLoS One. 10(10):e0140121, 2015
Yamaguchi S, Shibata R, Yamamoto N, Nishikawa M, Hibi H, Tanigawa T, Ueda M, Murohara T, Yamamoto A.Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion.Sci Rep. 5:16295, 2015
Hattori Y, Kim H, Tsuboi N, Yamamoto A, Akiyama S, Shi Y, Katsuno T, Kosugi T, Ueda M, Matsuo S, Maruyama S.Correction: Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury.PLoS One. 10(11):e0143561, 2015
（2016年〜）
Ishikawa J, Takahashi N, Matsumoto T, Yoshioka Y, Yamamoto N, Nishikawa M, Hibi H, Ishigro N, Ueda M, Furukawa K, Yamamoto A.Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis.Bone. 83:210-219, 2016
Shimojima C, Takeuchi H, Jin S, Parajuli B, Hattori H, Suzumura A, Hibi H, Ueda M, Yamamoto A.Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis.J Immunol. 196(10):4164-71, 2016
Hirata M, Ishigami M, Matsushita Y, Ito T, Hattori H, Hibi H, Goto H, Ueda M, Yamamoto A.Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis.Stem Cells Transl Med.5(10):1416-1424, 2016
Hishida S, Ozaki N, Honda T, Shigetomi T, Ueda M, Hibi H, Sugiura Y.Atrophy of submandibular gland by the duct ligation and a blockade of SP receptor in rats.Nagoya J Med Sci.78(2):215-27, 2016
（2017年〜）
Fujio M, Xing Z, Sharabi N, Xue Y, Yamamoto A, Hibi H, Ueda M, Fristad I, Mustafa K.Conditioned media from hypoxic-cultured human dental pulp cells promotes bone healing during distraction osteogenesis.J Tissue Eng Regen Med. 11(7):2116-2126, 2017
Al-Sharabi N, Mustafa M, Ueda M, Xue Y, Mustafa K, Fristad I.Conditioned medium from human bone marrow stromal cells attenuates initial inflammatory reactions in dental pulp tissue.Dent Traumatol. 33(1):19-26, 2017
Kano F, Matsubara K, Ueda M, Hibi H, Yamamoto A.Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and Monocyte Chemoattractant Protein-1 Synergistically Regenerate Transected Rat Peripheral Nerves by Altering Macrophage Polarity.Stem Cells. 35(3):641-653, 2017
Ito T, Ishigami M, Matsushita Y, Hirata M, Matsubara K, Ishikawa T, Hibi H, Ueda M, Hirooka Y, Goto H, Yamamoto A.Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity.Sci Rep. 7:44043, 2017
Itaya T, Hirai T, Hirai T, Numoto H, Takeda H, Ueda M.The Use of Fibroblasts for Ameliorating Structural Changes Associated with Skin Aging.Rejuvenation Res. 20(5):383-388, 2017
（2022年〜）
Neurology and Neurorehabilitation 2022, Vol. 4, Issue 2, 011-015 The First in Human Case of Amyotrophic Lateral Sclerosis Treated with Stem Cell-Derived Conditioned Medium: A 1-Year- Follow Up Minoru Ueda1,2* and Yasuhiro Seta3  1Department of Medicine, Postgraduate School of Medicine, Emeritus of Nagoya University, Nagoya, Japan 2President of SAISEIKEN Co. LTD, Tokyo, Japan  3Director of Smart Clinic Tokyo, Tokyo, Japan