アミロイド前駆体タンパク質
関連文献

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銅イオンと結合したAPPのCuBD。金属配位に関与する2つのヒスチジンと1つのチロシンの、Cu(I)結合状態、Cu(II)結合状態、非結合状態のコンフォメーションが示されているが、わずかな違いしか見られない。
細胞外のE2ドメインの二量体型コイルドコイル構造はショウジョウバエからヒトまで最も高度に保存されている領域の1つである。このドメインはスペクトリンの構造と類似しており、ヘパラン硫酸プロテオグリカンと結合すると考えられている。