MLH3
関連文献

“Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease”. Nature 375 (6534):  754–60. (Jun 1995). Bibcode: 1995Natur.375..754S. doi:10.1038/375754a0. PMID 7596406.
“The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2”. Nucleic Acids Research 29 (8):  1695–702. (Apr 2001). doi:10.1093/nar/29.8.1695. PMC 31313. PMID 11292842. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC31313/.
“Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers”. Human Mutation 17 (5):  389–96. (May 2001). doi:10.1002/humu.1114. PMID 11317354.
“A role for MLH3 in hereditary nonpolyposis colorectal cancer”. Nature Genetics 29 (2):  137–8. (Oct 2001). doi:10.1038/ng1001-137. PMID 11586295.
“The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination”. Human Molecular Genetics 11 (15):  1697–706. (Jul 2002). doi:10.1093/hmg/11.15.1697. PMID 12095912.
“Little evidence for involvement of MLH3 in colorectal cancer predisposition”. International Journal of Cancer 106 (2):  292–6. (Aug 2003). doi:10.1002/ijc.11218. PMID 12800209.
“Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes”. American Journal of Human Genetics 76 (1):  112–27. (Jan 2005). doi:10.1086/427268. PMC 1196414. PMID 15558497. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196414/.
“Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair”. Cancer Research 65 (23):  10759–66. (Dec 2005). doi:10.1158/0008-5472.CAN-05-2528. PMID 16322221.
“Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Research 16 (1):  55–65. (Jan 2006). doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129/.
“MLH3 mutation in endometrial cancer”. Cancer Research 66 (15):  7502–8. (Aug 2006). doi:10.1158/0008-5472.CAN-06-0248. PMID 16885347.
“Mutation screening of mismatch repair gene Mlh3 in familial esophageal cancer”. World Journal of Gastroenterology 12 (33):  5281–6. (Sep 2006). doi:10.3748/wjg.v12.i33.5281. PMC 4088192. PMID 16981255. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088192/.
“Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC”. Oncology Reports 17 (2):  351–4. (Feb 2007). doi:10.3892/or.17.2.351. PMID 17203173.
“Mutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functions”. DNA Repair 6 (10):  1463–70. (Oct 2007). doi:10.1016/j.dnarep.2007.04.013. PMC 2366940. PMID 17567544. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366940/.
減数分裂時の組換えに関する現行のモデル。二本鎖切断もしくはギャップの形成によって開始され、続いて相同染色体との対合、鎖の侵入によって組換え修復過程が開始される。ギャップの修復過程では、乗換え（CO）型もしくは非乗換え（NCO）型の組換えが行われる。乗換え型の組換えはダブルホリデイジャンクション（DHJ）モデルによって行われると考えられており、右側に示されている。非乗換え型の組換えは主にSDSA（Synthesis Dependent Strand Annealing）モデルで行われると考えられており、左側に示されている。組換えの大部分はSDSA型のようである。