長田裕之 (農芸化学者)
主な原著論文

Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M & Osada H: Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol 27, 186-196 (2020).
Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C & Myers CL: Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments. Nature Protoc (2019).
Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL & Boone C: Functional annotation of chemical libraries across diverse biological processes. Nature Chem Biol 13, 982-993 (2017).
Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Scholer HR & Waldmann H: Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of casein kinase 1. Cell Chem Biol 23, 494-507 (2016).
Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC & Challis GL: A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Commun 7, 13609 (2016).
Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T & Nishiyama M: Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces. Nature Chem Biol 12, 967-972 (2016).
Yun CS, Motoyama T & Osada H: Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme. Nature Commun 6, 8758 (2015).
Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y & Takashima A: Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nature Commun 6, 10216 (2015).
Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y & Osada H: Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation. Nature Chem Biol 7, 461-468 (2011).
Sun Y, Hahn F, Demydchuk Y, Chettle J, Tosin M, Osada H & Leadlay PF: In vitro reconstruction of tetronate RK-682 biosynthesis. Nature Chem Biol 6, 99-101 (2010).
Miyazaki I, Simizu S, Okumura H, Takagi S & Osada H: A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nature Chem Biol 6, 667-73 (2010).
Yano A, Tsutsumi S, Soga S, Lee MJ, Trepel J, Osada H & Neckers L: Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone. Proc Natl Acad Sci, USA. 105, 15541-6 (2008).
Kawatani M, Okumura H, Honda K, Kanoh N, Muroi M, Dohmae N, Takami M, Kitagawa M, Futamura Y, Imoto M & Osada H: The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I. Proc Natl Acad Sci, USA 105, 11691-11696 (2008).
Woo J-T, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K & Osada H: Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci, USA. 103, 4729-4734 (2006).
Watanabe N, Arai H, Iwasaki J-I, Shiina M, Ogata K, Hunter T & Osada H: Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc Natl Acad Sci, USA. 102, 11663-1668 (2005).
Watanabe N, Arai H, Nishihara Y, Taniguch M, Watanabe N, Hunter T & Osada H: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF{beta}-TrCP. Proc Natl Acad Sci, USA. 101, 4419-4424 (2004).
16.   Simizu S & Osada H: Mutations in the Plk gene lead to instability of Plk protein in human tumor cell lines. Nature Cell Biol 2, 852-854 (2000).