SMAD4
関連文献

“TGF-beta signaling by Smad proteins”. Cytokine & Growth Factor Reviews 11 (1–2):  15–22. (2000). doi:10.1016/S1359-6101(99)00025-8. PMID 10708949.
“The Smad pathway”. Cytokine & Growth Factor Reviews 11 (1–2):  5–13. (2000). doi:10.1016/S1359-6101(99)00024-6. PMID 10708948.
“Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells”. Cytokine & Growth Factor Reviews 10 (3–4):  187–99. (2000). doi:10.1016/S1359-6101(99)00012-X. PMID 10647776.
“TGF-beta signal transduction”. Annual Review of Biochemistry 67:  753–91. (1998). doi:10.1146/annurev.biochem.67.1.753. PMID 9759503.
“High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition”. BMC Cancer 7:  209. (2008). doi:10.1186/1471-2407-7-209. PMC 2186346. PMID 17997817. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186346/.
“Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II”. Molecular and Cellular Biology 27 (23):  8228–42. (Dec 2007). doi:10.1128/MCB.00374-07. PMC 2169171. PMID 17875924. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169171/.
“High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome”. Journal of Medical Genetics 44 (11):  702–9. (Nov 2007). doi:10.1136/jmg.2007.052506. PMC 2752176. PMID 17873119. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752176/.
“The utility of SMAD4 as a diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors”. Diagnostic Cytopathology 35 (10):  644–8. (Oct 2007). doi:10.1002/dc.20715. PMID 17854080.
“Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance”. American Journal of Human Genetics 81 (4):  799–807. (Oct 2007). doi:10.1086/520001. PMC 2227929. PMID 17847004. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2227929/.
“Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer”. World Journal of Gastroenterology 13 (27):  3714–20. (Jul 2007). doi:10.3748/wjg.v13.i27.3714. PMC 4250643. PMID 17659731. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250643/.
“Smad4-independent, PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells”. Experimental Cell Research 313 (15):  3167–74. (Sep 2007). doi:10.1016/j.yexcr.2007.05.028. PMID 17643425.
“TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways”. American Journal of Physiology. Lung Cellular and Molecular Physiology 293 (3):  L790–9. (Sep 2007). doi:10.1152/ajplung.00099.2007. PMC 2413071. PMID 17601799. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413071/.
“Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation”. Molecular and Cellular Biology 27 (17):  6068–83. (Sep 2007). doi:10.1128/MCB.00664-07. PMC 1952153. PMID 17591695. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952153/.
“Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells”. Cellular Signalling 19 (8):  1722–32. (Aug 2007). doi:10.1016/j.cellsig.2007.03.008. PMID 17478078.
“Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression”. Journal of Molecular Medicine 85 (7):  753–62. (Jul 2007). doi:10.1007/s00109-007-0180-7. PMID 17476473. http://ousar.lib.okayama-u.ac.jp/12990.
“The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells”. Proteomics 7 (11):  1929–40. (Jun 2007). doi:10.1002/pmic.200700072. PMID 17469085.
“K-ras and Dpc4 mutations in chronic pancreatitis: case series”. Croatian Medical Journal 48 (2):  218–24. (Apr 2007). PMC 2080529. PMID 17436386. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080529/.
“Loss of Smad4 expression predicts liver metastasis in human colorectal cancer”. Oncology Reports 17 (5):  1095–9. (May 2007). doi:10.3892/or.17.5.1095. PMID 17390050.
“Smad4 is critical for self-renewal of hematopoietic stem cells”. The Journal of Experimental Medicine 204 (3):  467–74. (Mar 2007). doi:10.1084/jem.20060465. PMC 2137898. PMID 17353364. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137898/.
“Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1”. Journal of Biochemistry 141 (3):  345–51. (Mar 2007). doi:10.1093/jb/mvm039. PMID 17301079.
ヒトHomo sapiensの18番染色体のバンドパターン。SMAD4遺伝子は長腕（q）21.1に位置し、この図では12.3と21.2の間の黒いストライプの部分に相当する。
GGCTモチーフに結合したSMAD4のMH1ドメイン、PDB: 5MEZ​
GGCGCモチーフに結合したSMAD4のMH1ドメインの拡大図、PDB: 5MEY​
GGCGCモチーフに結合したSMAD4のMH1ドメイン、PDB: 5MEY​