肝毒性
参考資料

Friedman, Scott E.; Grendell, James H.; McQuaid, Kenneth R. (2003). Current diagnosis & treatment in gastroenterology. New York: Lang Medical Books/McGraw-Hill. pp. 664–679. ISBN 978-0-8385-1551-8.
Dixit, Vaibhav A. (2019). "A simple model to solve a complex drug toxicity problem". Toxicology,Research. 8 (2):157171. doi:10.1039/C8TX00261D. PMC 6417485. PMID 30997019.
Ostapowicz G, Fontana RJ, Schiødt FV, et al. (2002). "Results of a prospective study of acute liver failure at 17 tertiary care centres in the United States". Ann. Intern. Med. 137 (12).947–54. doi:10.7326/0003-4819-1371220021217000007. PMID 12484709. S2CID 11390513.
Pirmohamed M, Breckenridge AM, Kitteringham NR, Park BK (1998). "Adverse drug reactions". BMJ. 316 (7140):12958. doi:10.1136/bmj.316.7140.1295. PMC 1113033. PMID 9554902.
Manov I, Motanis H, Frumin I, Iancu TC (2006). "Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects". Acta Pharmacol. Sin. 27 (3): 259–72. doi:10.1111/j.1745-7254.2006.00278.x. PMID 16490160. S2CID 26874901.
Alpers DH, Sabesin SM (1982). Schiff L; Schiff ER (eds.). Diseases of the liver. Philadelphia: JB Lippincott. pp. 813–45
Chalasani, Naga P.; Hayashi, Paul H.; Bonkovsky, Herbert L.; Navarro, Victor J.; Lee, William M.; Fontana, Robert J.; Practice Parameters Committee of the American College of Gastroenterology (2014). "ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury". The American Journal of Gastroenterology. 109 (7):950966. doi:10.1038/ajg.2014.131. PMID 24935270. S2CID 2417493
Patel T, Roberts LR, Jones BA, Gores GJ (1998). "Dysregulation of apoptosis as a mechanism of liver disease: an overview". Semin. Liver Dis. 18 (2): 105–14. doi:10.1055/s-2007-1007147. PMID 9606808
Mumoli N, Cei M, Cosimi A (2006). "Drug-related hepatotoxicity". N. Engl. J. Med. 354 (20):21913,author,reply21913. doi:10.1056/NEJMc060733. PMID 16710915
Bénichou C (1990). "Criteria of drug-induced liver disorders. Report of an international consensus meeting". J. Hepatol. 11 (2): 272–6. doi:10.1016/0168-8278(90)90124-A. PMID 2254635
Blazka ME, Wilmer JL, Holladay SD, Wilson RE, Luster MI. (1995) Role of pro‑inflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 1995;133:43‑52
Yadav V, Rai R, Yadav A, Pahuja M, Solanki S, et al. (2012) Evaluation of antibacterial activity of Callicarpa macrophylla Vahl. stem extracts
Siddiqui H (1993) Safety of herbal drugs-an overview. Drugs News Views
Kumar A, Rohal A, Chakraborty S, Tiwari R, Latheef SK, et al. (2013) Ocimum sanctum (Tulsi): a miracle herb and boon to medical science Review. Int J Agron Plant Prod 4: 589
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, et al. (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4:1
Singh N, Verma P, Pandey BR, Bhalla M (2012) Therapeutic potential of Ocimum sanctum in prevention and treatment of cancer and exposure to radiation: An overview. Int J Pharmacist Sci Drug Res 4: 97-104.
Mondal S, Mirdha BR, Mahapatra SC (2009) The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J Physiol Pharmacol 53: 291-306.
Devra D, Mathur KC, Agrawal RP, Bhadu I, Goyal S, et al. (2012) Effect of Tulsi (Ocimum sanctum Linn.) on Clinical and Biochemical Parameters of Metabolic Syndrome. J Nat Remedies 12: 63-67
Ahmad I, Beg AZ (2001) Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. Ethnopharmacol 74: 113-123.
Amadi J, Salami S, Eze C (2010) Antifungal properties and phytochemical screening of extracts of African basil (Ocimum gratissimum L.). Agr Biol J North America 1: 163-166.
Ponnusam Y, Louis T, Madhavachandran V, Kumar S, Thoprani N, et al. (2015) Antioxidant Activity of The Ancient Herb, Holy Basil in CCl4-Induced Liver Injury in Rats. Ayurvedic 2: 34-38.
Ravi V, Parida S, Desai A, Chandramukhi A, Devi MG, et al. (1997) Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients. J Med Virol 51: 132-136.
Kumari P, Yadav P, Verma PR, Kumar, Arya, Kumar S, et al. (2013) A review on wound healing properties of Indian medicinal plants. Ind J Fund Appl Life Sci 3: 220-232.
Kumar A, Agarwal K, Maurya AK, Shanker K, Bushra U, et al. (2015) Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its anti-inflammatory, analgesic and antipyretic activities. Pharmacogn Mag 11: S217.
Ranjana T, Tripathi V (2015) Therapeutic effect of tulsi (Ocimum sanctum Linn) in general and oral health. Ayurlog: National Journal of Research in Ayurveda Science 3: 1-12.
Suanarunsawat T, Ayutthaya WDN, Thirawarapan S, Poungshompoo S (2014) Anti-oxidative, anti-hyperglycemic and lipid-lowering effects of aqueous extracts of Ocimum sanctum L. leaves in diabetic rats. Food Nutr Sci 5: 801-811.
Talekar, Y. P., Das, B., Paul, T., Talekar, D. Y., Apte 1, K. G., & Parab, P. B. (2012). Evaluation of hepatoprotective Potential of Aqueous and Ethanolic Extract of Ocimum sanctum Linn. In Wistar Rats. Asian Journal of Pharmaceutical and Clinical Research, 5(4), 141-145.
Singh V, Kumar R.(2017).Study of Phytochemical Analysis and Antioxidant Activity of Allium sativum of Bundelkhand Region. International Journal of Life Sciences Scientific Research. 3(6):1451-1458.
Raaman N.(2006). Phytochemical Techniques. New India Publishing Agency, New Delhi, 19-24.
Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H.(2011). Phytochemical screening and Extraction: A Review. Internationale Pharmaceutica Sciencia. 1(1):98-106.
Auwal MS, Saka S, Mairiga IA, Sanda KA, Shuaibu A and Ibrahim A.(2014) Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). Veterinary Research Forum.5(2):95-100.
Sadasivam S, Manickam A, Biochemical methods.(2005). Edn 3, New Age International Limited, Publishers, New Delhi. 1-4.
Basumatary AR.(2016).Preliminary Phytochemical Screening of some compounds from plant stem bark extracts of Tabernaemontana divaricata Linn. used by Bodo Community at Kokrajhar District, Assam, India. Archives of Applied Science Research.8(8):47-52
Silva GO, Abeysundara AT, Aponso MM.(2017). Extraction methods, qualitative and quantitative techniques for screening of phytochemicals from plants. American Journal of Essential Oils and Natural Products.5(2):29-32
Jagessar RC.(2017). Phytochemical screening and chromatographic profile of the ethanolic and aqueous extract of Passiflora edulis and Vicia faba L. (Fabaceae). Journal of Pharmacognosy and Phytochemistry.6(6):1714-1721
Gul R, Jan SU, Syed F, Sherani F, Nusrat Jahan.(2017).Preliminary Phytochemical Screening, Quantitative Analysis of Alkaloids, and Antioxidant Activity of Crude Plant Extracts from Ephedra intermedia Indigenous to Balochistan. The Scientific World Journal.1-7
Rubin, E., Hutter, F., Proper, H. (1963). Cell proliferation and fiber formation in chronic carbon tetrachloride intoxication. A morphologic and chemical study. American Journal of Pathology 42, 715.
Recnagal, R. (1983). Carbon tetrachloride hepatotoxicity, status quo and future prospects. Trends in Pharmacological Science 4, 129–131.
Slater, T.F. (1978). Biochemical Studies on Liver Injury. Academic Press, New York, pp. 1–44.
Reitman, S., Frankel, S. (1957). A colorimetric method for the determination of serum glutamate oxaloacetate transaminases. American Journal of Clinical Pathology 28, 56–63.
Malloy, H.T., Evelyn, K.A. (1937). The determination of bilirubin with the photometric colorimeter. Journal of Biological Chemistry 119, 481–490.
Kind, P.R.N., Kings, E.J. (1976). Determination of serum bilirubin. Journal Clinical Pathology 7, 322–330.
Brand-Williams, W.; Cuvelier, M.E.; Berset, C. (1995). Use of a free radical method to evaluate antioxidant activity. LWT—Food Sci. Technol. 28, 25–30.
Shah, N.A.; Khan, M.R.; Ahmad, B.; Noureen, F.; Rashid, U.; Khan, R.A. (2013) Investigation on flavonoid composition and anti-free radical potential of Sida cordata. BMC Complement. Altern. Med, 13, 276.
Zengin, G.; Aktumsek, A.; Guler, G.O.; Cakmak, Y.S.; Yildiztugay, E. (2011). Antioxidant properties of methanolic extract and fatty acid composition of Centaurea urvillei DC. Subsp. Hayekiana Wagenitz. Rec. Nat. Prod., 5, 123–132.
Mitsuda, H.; Yasumoto, K.; Iwami, K. (1966). Antioxidative action of indole compounds during the autooxidation of linoleic acid. Nippon Eiyo Shokuryo Gakkaishi, 19, 210–214
Baccanari, D.; Phillips, A.; Smith, S.; Sinski, D.; Burchall, J. (1975-12-02). “Purification and properties of Escherichia coli dihydrofolate reductase”. Biochemistry 14 (24):  5267–5273. doi:10.1021/bi00695a006. ISSN 0006-2960. PMID 46. https://pubmed.ncbi.nlm.nih.gov/46.
アセトアミノフェン分子の3Dモデル。過量投与により肝障害を引き起こす。
アキーの実
肝臓での薬物代謝：
転移酵素は、グルタチオン、硫酸、酢酸、グルクロン酸。
P-450はシトクロムP-450。
薬剤A、B、Cで異なる経路を示す。
薬剤性肝障害が疑われる場合のアルゴリズム