Piala Belgia 2018–19
Putaran Keenam

Pengundian babak keenam dilakukan pada 28 Agustus 2018 dan melibatkan 16 tim dari Divisi Pertama Belgia A, yang semuanya diunggulkan dan tidak dapat bertemu satu sama lain.  Semua tim non-profesional (divisi 3 dan di bawahnya) otomatis mendapat keuntungan sebagai tuan rumah jika stadion mereka memiliki kapasitas dan kecerahan lampu sorot yang memadai, seperti yang dialami semua tim kecuali Duffel dan Mandel United.
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| 25 September 2018 | Eupen (1) | 3–0 | Tubize (2) | Eupen |  |
| 20:00 CEST | Lotiès  11' Yagan  37' Laurent  90' | Laporan |  | Stadion: Kehrwegstadion  |     |
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| 25 September 2018 | Waasland-Beveren (1) | 1–2 | Mandel United (4) | Beveren |  |
| 20:00 CEST | Salquist  69' |  | de Oliveira  15' Beyens  39' | Stadion: Freethiel Stadion  |     |
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| 25 September 2018 | Harelbeke (4) | 0–1 | Kortrijk (1) | Harelbeke |  |
| 20:30 CEST |  | Laporan | Chevalier  78' | Stadion: Forestiersstadion  |     |
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| 26 September 2018 | Genk (1) | 4–0 | Lommel (2) | Genk |  |
| 20:00 CEST | Wouters  2' Zhegrova  8' Seck  71' Ingvartsen  88' | Laporan |  | Stadion: Luminus Arena  |     |
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| 26 September 2018 | Olympic Charleroi (4) | 2–5 | Lokeren (1) | Charleroi |  |
| 20:00 CEST | Somé  44' Virgone  63' | Laporan | Skúlason  4', 79' (pen.) Filipović  24' Cevallos  28' (pen.) Saroka  49' | Stadion: Stade de la Neuville  |     |
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| 26 September 2018 | Virton (3) | 2–4 | Gent (1) | Virton |  |
| 20:00 CEST | François  28' Joachim  63' | Laporan | Awoniyi  3', 89' Limbombe  78', 90+4' | Stadion: Stade Yvan Georges  |     |
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| 26 September 2018 | Cercle Brugge (1) | 1–2 | Beerschot Wilrijk (2) | Bruges |  |
| 20:00 CEST | Gakpé  11' | Laporan | Noubissi  26' Hoffer  87' | Stadion: Jan Breydel Stadium  |     |
| 0 | 1 | 2 | 3 | 4 | 5 |
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| 26 September 2018 | Heist (3) | 1–2 | Zulte Waregem (1) | Heist-op-den-Berg |  |
| 20:30 CEST | Ventose  63' | Laporan | De Pauw  18' Harbaoui  39' (pen.) |  |     |
| 0 | 1 | 2 | 3 | 4 | 5 |
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| 26 September 2018 | Sint-Truiden (1) | 3–0 | Duffel (4) | Sint-Truiden |  |
| 20:30 CEST | De Bruyn  27' Bezus  36' (pen.) Nazon  47' | Laporan |  | Stadion: Stayen  |     |
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| 26 September 2018 | Dessel Sport (3) | 0–3 | Excel Mouscron (1) | Dessel |  |
| 20:30 CEST |  | Laporan | Pierrot  51' Benson  65', 90+3' | Stadion: Armand Melisstadion  |     |
| 0 | 1 | 2 | 3 | 4 | 5 |
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| 26 September 2018 | Hoogstraten (4) | 1–3 | Oostende (1) | Hoogstraten |  |
| 20:30 CEST | Bokila  52' | Laporan | Guri  9' Faes  61' Milović  63' |  |     |
| 0 | 1 | 2 | 3 | 4 | 5 |
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| 26 September 2018 | Eendracht Aalst (3) | 0–2 | Charleroi (1) | Aalst |  |
| 20:30 CEST |  | Laporan | Osimhen  90+2' Benavente  90+5' | Stadion: Pierre Cornelisstadion  |     |
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| 26 September 2018 | Standard Liège (1) | 1–2 | Knokke (3) | Stade Maurice Dufrasne |  |
| 20:30 CEST | Sá  58' | Laporan | Luyindama  47' (b.d.) Dhondt  73' |  |     |
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| 26 September 2018 | Deinze (3) | 2–0 | Club Brugge (1) | Deinze |  |
| 20:30 CEST | Tarfi  33' De Greef  70' | Laporan |  | Stadion: Burgemeester Van de Wiele Stadion  |     |
| 0 | 1 | 2 | 3 | 4 | 5 |
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| 26 September 2018 | KV Mechelen (2) | 3–1 | Antwerp (1) | Mechelen |  |
| 20:45 CEST | De Witte  29' Engvall  51' Van Damme  87' | Laporan | Mbokani  36' | Stadion: Achter de Kazerne  |     |
| 0 | 1 | 2 | 3 | 4 | 5 |
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| 27 September 2018 | Anderlecht (1) | 0–3 | Union SG (2) | Anderlecht |  |
| 20:45 CEST |  | Laporan | Niakaté  43', 76', 83' | Stadion: Constant Vanden Stock Stadium  |     |