Aktris Terbaik (Saturn Award)
Pemenang dan nominee > 2000an

| Tahun | Aktris | Karakter | Film |
| --- | --- | --- | --- |
| 2000 | Téa Leoni | Kate Reynolds / Kate Campbell | The Family Man |
| 2000 | Cate Blanchett | Annabelle "Annie" Wilson | The Gift |
| 2000 | Ellen Burstyn ‡ | Sara Goldfarb | Requiem for a Dream |
| 2000 | Jennifer Lopez | Dr. Catherine Deane | The Cell |
| 2000 | Michelle Pfeiffer | Claire Spencer | What Lies Beneath |
| 2000 | Michelle Yeoh | Yu Shu Lien | Crouching Tiger, Hidden Dragon |
| 2001 | Nicole Kidman | Grace Stewart | The Others |
| 2001 | Kate Beckinsale | Sara Thomas | Serendipity |
| 2001 | Angelina Jolie | Lara Croft | Lara Croft: Tomb Raider |
| 2001 | Julianne Moore | Clarice Starling | Hannibal |
| 2001 | Frances O'Connor | Monica Swinton | A.I. Artificial Intelligence |
| 2001 | Naomi Watts | Betty Elms | Mulholland Drive |
| 2002 | Naomi Watts | Rachel Keller | The Ring |
| 2002 | Kirsten Dunst | Mary Jane Watson | Spider-Man |
| 2002 | Jodie Foster | Meg Altman | Panic Room |
| 2002 | Milla Jovovich | Alice | Resident Evil |
| 2002 | Natascha McElhone | Rheya | Solaris |
| 2002 | Natalie Portman | Senator Padmé Amidala | Star Wars: Episode II – Attack of the Clones |
| 2003 | Uma Thurman | The Bride | Kill Bill: Volume 1 |
| 2003 | Kate Beckinsale | Selene | Underworld |
| 2003 | Jessica Biel | Erin Hardesty | The Texas Chainsaw Massacre |
| 2003 | Cate Blanchett | Magdalena "Maggie" Gilkeson | The Missing |
| 2003 | Jennifer Connelly | Betty Ross | Hulk |
| 2003 | Jamie Lee Curtis | Tess Coleman / Anna Coleman | Freaky Friday |
| 2004 | Blanchard Ryan | Susan Watkins | Open Water |
| 2004 | Nicole Kidman | Anna | Birth |
| 2004 | Julianne Moore | Telly Paretta | The Forgotten |
| 2004 | Uma Thurman | The Bride / Beatrix Kiddo | Kill Bill: Volume 2 |
| 2004 | Kate Winslet ‡ | Clementine Kruczynski | Eternal Sunshine of the Spotless Mind |
| 2004 | Zhang Ziyi | Mei | House of Flying Daggers |
| 2005 | Naomi Watts | Ann Darrow | King Kong |
| 2005 | Jodie Foster | Kyle Pratt | Flightplan |
| 2005 | Laura Linney | Erin Christine Bruner | The Exorcism of Emily Rose |
| 2005 | Rachel McAdams | Lisa Reisert | Red Eye |
| 2005 | Natalie Portman | Padmé Amidala | Star Wars: Episode III – Revenge of the Sith |
| 2005 | Tilda Swinton | Jadis, the White Witch | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe |
| 2006 | Natalie Portman | Evey Hammond | V for Vendetta |
| 2006 | Kate Bosworth | Lois Lane | Superman Returns |
| 2006 | Judi Dench ‡ | Barbara Covett | Notes on a Scandal |
| 2006 | Maggie Gyllenhaal | Ana Pascal | Stranger than Fiction |
| 2006 | Shauna Macdonald | Sarah | The Descent |
| 2006 | Renée Zellweger | Beatrix Potter | Miss Potter |
| 2007 | Amy Adams | Putri Giselle | Enchanted |
| 2007 | Helena Bonham Carter | Mrs. Lovett | Sweeney Todd: The Demon Barber of Fleet Street |
| 2007 | Carice van Houten | Rachel Stein/Ellis de Vries | Black Book |
| 2007 | Ashley Judd | Agnes White | Bug |
| 2007 | Belén Rueda | Laura | The Orphanage |
| 2007 | Naomi Watts | Anna Khitrova | Eastern Promises |
| 2008 | Angelina Jolie ‡ | Christine Collins | Changeling |
| 2008 | Cate Blanchett | Daisy Fuller | The Curious Case of Benjamin Button |
| 2008 | Maggie Gyllenhaal | Rachel Dawes | The Dark Knight |
| 2008 | Julianne Moore | Istri Dokter | Blindness |
| 2008 | Emily Mortimer | Jessie | Transsiberian |
| 2008 | Gwyneth Paltrow | Virginia "Pepper" Potts | Iron Man |
| 2009 | Zoe Saldana | Neytiri | Avatar |
| 2009 | Catherine Keener | Connie | Where the Wild Things Are |
| 2009 | Mélanie Laurent | Shoshanna Dreyfus/Emmanuelle Mimieux | Inglourious Basterds |
| 2009 | Alison Lohman | Christine Brown | Drag Me to Hell |
| 2009 | Natalie Portman | Grace Cahill | Brothers |
| 2009 | Charlize Theron | Sylvia | The Burning Plain |