Film Terbaik (Independent Spirit Award)
Pemenang dan nominee > 2000an

| Tahun | Pemenang | Perusahaan distribusi | Sutradara |
| --- | --- | --- | --- |
| 2000 | Crouching Tiger, Hidden Dragon ‡ | Sony Pictures Classics | Ang Lee |
| 2000 | Before Night Falls | Fine Line Features | Julian Schnabel |
| 2000 | George Washington | ContentFilm International | David Gordon Green |
| 2000 | Ghost Dog: The Way of the Samurai | Artisan Entertainment | Jim Jarmusch |
| 2000 | Requiem for a Dream  | Artisan Entertainment | Darren Aronofsky |
| 2001 | Memento | Newmarket Films | Christopher Nolan |
| 2001 | Hedwig and the Angry Inch | Fine Line Features | John Cameron Mitchell |
| 2001 | L.I.E. | New Yorker Films | Michael Cuesta |
| 2001 | Things Behind the Sun | Showtime Networks | Allison Anders |
| 2001 | Waking Life | Fox Searchlight | Richard Linklater |
| 2002 | Far from Heaven | Focus Features | Todd Haynes |
| 2002 | The Good Girl | Fox Searchlight | Miguel Arteta |
| 2002 | Lovely & Amazing | Lions Gate Films | Nicole Holofcener |
| 2002 | Secretary | Lions Gate Films | Steven Shainberg |
| 2002 | Tully | Telltale Films | Hilary Birmingham |
| 2003 | Lost in Translation ‡ | Focus Features | Sofia Coppola |
| 2003 | American Splendor | HBO Films | Shari Springer Berman dan Robert Pulcini |
| 2003 | In America | Fox Searchlight | Jim Sheridan |
| 2003 | Raising Victor Vargas | Samuel Goldwyn Films | Peter Sollett |
| 2003 | Shattered Glass | Lions Gate Films | Billy Ray |
| 2004 | Sideways ‡ | Fox Searchlight | Alexander Payne |
| 2004 | Baadasssss! | Sony Pictures Classics | Mario Van Peebles |
| 2004 | Kinsey | Fox Searchlight | Bill Condon |
| 2004 | Maria Full of Grace | Fine Line Features | Joshua Marston |
| 2004 | Primer | THINKFilm | Shane Carruth |
| 2005 | Brokeback Mountain ‡ | Focus Features | Ang Lee |
| 2005 | Capote ‡ | Sony Pictures Classics | Bennett Miller |
| 2005 | Good Night, and Good Luck ‡ | Warner Independent Pictures | George Clooney |
| 2005 | The Squid and the Whale | Samuel Goldwyn Films | Noah Baumbach |
| 2005 | The Three Burials of Melquiades Estrada | Sony Pictures Classics | Tommy Lee Jones |
| 2006 | Little Miss Sunshine ‡ | Fox Searchlight | Jonathan Dayton dan Valerie Faris |
| 2006 | American Gun | IFC Films | Aric Avelino |
| 2006 | The Dead Girl | First Look International | Karen Moncrieff |
| 2006 | Half Nelson | THINKFilm | Ryan Fleck |
| 2006 | Pan's Labyrinth | Picturehouse | Guillermo del Toro |
| 2007 | Juno ‡ | Fox Searchlight | Jason Reitman |
| 2007 | The Diving Bell and the Butterfly | Miramax Films | Julian Schnabel |
| 2007 | I'm Not There | The Weinstein Company | Todd Haynes |
| 2007 | A Mighty Heart | Paramount Vantage | Michael Winterbottom |
| 2007 | Paranoid Park | IFC Films | Gus Van Sant |
| 2008 | The Wrestler | Fox Searchlight | Darren Aronofsky |
| 2008 | Ballast | Alluvial Film Company | Lance Hammer |
| 2008 | Frozen River | Sony Pictures Classics | Courtney Hunt |
| 2008 | Rachel Getting Married | Sony Pictures Classics | Jonathan Demme |
| 2008 | Wendy and Lucy | Oscilloscope Pictures | Kelly Reichardt |
| 2009 | Precious ‡ | Lionsgate | Lee Daniels |
| 2009 | (500) Days of Summer | Fox Searchlight | Marc Webb |
| 2009 | Amreeka | Virgil Films & Entertainment | Cherien Dabis |
| 2009 | The Last Station | Sony Pictures Classics | Michael Hoffman |
| 2009 | Sin Nombre | Focus Features | Cary Fukunaga |