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Filmografi > Film

| Tahun | Judul | Peran | Sutradara | Catatan |
| --- | --- | --- | --- | --- |
| 1988 | Big Top Pee-wee | Duke, The Dog-Faced Boy | Randal Kleiser |  |
| 1989 | Licence to Kill | Dario | John Glen |  |
| 1991 | The Indian Runner | Miguel Aguilera | Sean Penn |  |
| 1992 | Christopher Columbus: The Discovery | Alvaro Harana | John Glen |  |
| 1993 | Fearless | Manny Rodrigo | Peter Weir |  |
| 1993 | Golden Balls | Bob, the friend from Miami | Bigas Luna |  |
| 1993 | Money for Nothing | Dino Palladino | Ramón Menéndez |  |
| 1994 | Swimming with Sharks | Rex | George Huang |  |
| 1994 | China Moon | Detective Lamar Dickey | John Bailey |  |
| 1995 | The Usual Suspects | Fred Fenster | Bryan Singer |  |
| 1995 | Submission | — | Himself | Film pendek; sutradara, penulis dan produser |
| 1996 | The Funeral | Gaspare Spoglia | Abel Ferrara |  |
| 1996 | The Fan | Juan Primo | Tony Scott |  |
| 1996 | Cannes Man | Himself | Susan Hito Shapiro | Kameo |
| 1996 | Basquiat | Benny Dalmau | Julian Schnabel |  |
| 1996 | Joyride | Detective López | Quinton Peeples |  |
| 1997 | Excess Baggage | Vincent Roche | Marco Brambilla |  |
| 1998 | Fear and Loathing in Las Vegas | Dr. Gonzo | Terry Gilliam |  |
| 2000 | Traffic | Javier Rodríguez Rodríguez | Steven Soderbergh | Received the Oscar for Best Supporting Actor |
| 2000 | The Way of the Gun | Harold Longbaugh | Christopher McQuarrie |  |
| 2000 | Snatch | Franky "Four Fingers" | Guy Ritchie |  |
| 2000 | Bread and Roses | Himself | Ken Loach | Tidak dikreditkan kameo |
| 2001 | The Pledge | Toby Jay Wadenah | Sean Penn |  |
| 2003 | 21 Grams | Jack Jordan | Alejandro González Iñárritu |  |
| 2003 | The Hunted | Sergeant Aaron Hallam | William Friedkin |  |
| 2005 | Sin City | Lieutenant Jack "Iron Jack" Rafferty / "Jackie Boy" | Frank Miller & Robert Rodriguez |  |
| 2007 | Things We Lost in the Fire | Jerry Sunborne | Susanne Bier |  |
| 2008 | Che | Che Guevara | Steven Soderbergh | Also producer |
| 2010 | The Wolfman | Lawrence Talbot / The Wolfman | Joe Johnston | Juga produser |
| 2010 | Somewhere | Himself | Sofia Coppola | Tidak dikreditkan kameo |
| 2011 | The Upsetter | Narrator | Ethan Higbee & Adam Bhala Lough | Suara |
| 2012 | Savages | Miguel "Lado" Arroyo | Oliver Stone |  |
| 2012 | 7 Days in Havana | — | Himself | Sutradara; segment: El Yuma |
| 2013 | Jimmy Picard | Jimmy Picard | Arnaud Desplechin |  |
| 2013 | Thor: The Dark World | Taneleer Tivan / The Collector | Alan Taylor | Tidak dikreditkan kameo |
| 2014 | Guardians of the Galaxy | Taneleer Tivan / The Collector | James Gunn |  |
| 2014 | Inherent Vice | Sauncho Smilax | Paul Thomas Anderson |  |
| 2014 | Escobar: Paradise Lost | Pablo Escobar | Andrea Di Stefano |  |
| 2015 | A Perfect Day | Mambrú | Fernando León de Aranoa |  |
| 2015 | Sicario | Alejandro Gillick | Denis Villeneuve |  |
| 2015 | The Little Prince | The Snake | Mark Osborne | Suara |
| 2017 | Song to Song |  | Terrence Malick | Adegan dihapus |
| 2017 | Star Wars: The Last Jedi | D.J. | Rian Johnson |  |
| 2018 | Avengers: Infinity War | Taneleer Tivan / The Collector | Anthony and Joe Russo | Kameo |
| 2018 | Sicario: Day of the Soldado | Alejandro Gillick | Stefano Sollima |  |
| 2019 | Dora and the Lost City of Gold | Swiper The Fox | James Bobin | Suara |
| 2021 | No Sudden Move | Ronald Russo | Steven Soderbergh |  |
| 2021 | The French Dispatch | Moses Rosenthaler | Wes Anderson |  |
| TBA | All-Star Weekend | Dr. Phill | Jamie Foxx | Lengkap |
| TBA | Reptile | Nichols | Grant Singer | Syuting, juga produser eksekutif |