Aktris Terbaik (Screen Actors Guild Award)
Pemenang dan nominasi > 2000-an

| Tahun | Aktris | Film | Peran | Ref>  |
| --- | --- | --- | --- | --- |
| 2000 (ke-7) | Julia Roberts  | Erin Brockovich | Erin Brockovich |  |
| 2000 (ke-7) | Joan Allen | The Contender | Laine Hanson |  |
| 2000 (ke-7) | Juliette Binoche | Chocolat | Vianne Liberato |  |
| 2000 (ke-7) | Ellen Burstyn | Requiem for a Dream | Sara Goldfarb |  |
| 2000 (ke-7) | Laura Linney | You Can Count on Me | Sammy Taylor |  |
| 2001 (ke-8) | Halle Berry  | Monster's Ball | Leticia Musgrove |  |
| 2001 (ke-8) | Jennifer Connelly   memenangkan Academy Award untuk Aktris Pendukung Terbaik | A Beautiful Mind | Alicia Nash |  |
| 2001 (ke-8) | Judi Dench | Iris | Iris Murdoch |  |
| 2001 (ke-8) | Sissy Spacek | In the Bedroom | Ruth Fowler |  |
| 2001 (ke-8) | Renée Zellweger | Bridget Jones's Diary | Bridget Jones |  |
| 2002 (ke-9) | Renée Zellweger | Chicago | Roxie Hart |  |
| 2002 (ke-9) | Salma Hayek | Frida | Frida Kahlo |  |
| 2002 (ke-9) | Nicole Kidman  | The Hours | Virginia Woolf |  |
| 2002 (ke-9) | Diane Lane | Unfaithful | Connie Sumner |  |
| 2002 (ke-9) | Julianne Moore | Far from Heaven | Cathy Whitaker |  |
| 2003 (ke-10) | Charlize Theron  | Monster | Aileen Wuornos |  |
| 2003 (ke-10) | Patricia Clarkson | The Station Agent | Olivia Harris |  |
| 2003 (ke-10) | Diane Keaton | Something's Gotta Give | Erica Barry |  |
| 2003 (ke-10) | Naomi Watts | 21 Grams | Cristina Gallagher |  |
| 2003 (ke-10) | Evan Rachel Wood | Thirteen | Tracy Freeland |  |
| 2004 (ke-11) | Hilary Swank  | Million Dollar Baby | Maggie Fitzgerald |  |
| 2004 (ke-11) | Annette Bening | Being Julia | Julia Lambert |  |
| 2004 (ke-11) | Catalina Sandino Moreno | Maria Full of Grace | Maria Álvarez |  |
| 2004 (ke-11) | Imelda Staunton | Vera Drake | Vera Drake |  |
| 2004 (ke-11) | Kate Winslet | Eternal Sunshine of the Spotless Mind | Clemetine Kruczynski |  |
| 2005 (ke-12) | Reese Witherspoon  | Walk the Line | June Carter Cash |  |
| 2005 (ke-12) | Judi Dench | Mrs Henderson Presents | Laura Henderson |  |
| 2005 (ke-12) | Felicity Huffman | Transamerica | Bree Hoffman |  |
| 2005 (ke-12) | Charlize Theron | North Country | Josey Aimes |  |
| 2005 (ke-12) | Ziyi Zhang | Memoirs of a Geisha | Sayuri Takanasja |  |
| 2006 (ke-13) | Helen Mirren  | The Queen | Queen Elizabeth II |  |
| 2006 (ke-13) | Penélope Cruz | Volver | Raimunda |  |
| 2006 (ke-13) | Judi Dench | Notes on a Scandal | Barbara Covett |  |
| 2006 (ke-13) | Meryl Streep | The Devil Wears Prada | Miranda Priestly |  |
| 2006 (ke-13) | Kate Winslet | Little Children | Sarah Pierce |  |
| 2007 (ke-14) | Julie Christie | Away from Her | Fiona Anderson |  |
| 2007 (ke-14) | Cate Blanchett | Elizabeth: The Golden Age | Queen Elizabeth I |  |
| 2007 (ke-14) | Marion Cotillard  | La Vie en Rose (La môme) | Édith Piaf |  |
| 2007 (ke-14) | Angelina Jolie | A Mighty Heart | Mariane Pearl |  |
| 2007 (ke-14) | Elliot Page | Juno | Juno MacGuff |  |
| 2008 (ke-15) | Meryl Streep | Doubt | Sister Aloysius Beauvier |  |
| 2008 (ke-15) | Anne Hathaway | Rachel Getting Married | Kym Ryder |  |
| 2008 (ke-15) | Angelina Jolie | Changeling | Christine Collins |  |
| 2008 (ke-15) | Melissa Leo | Frozen River | Ray Eddy |  |
| 2008 (ke-15) | Kate Winslet | Revolutionary Road | April Wheeler |  |
| 2009 (ke-16) | Sandra Bullock  | The Blind Side | Leigh Anne Tuohy |  |
| 2009 (ke-16) | Helen Mirren | The Last Station | Sophia Tolstaya |  |
| 2009 (ke-16) | Carey Mulligan | An Education | Jenny Mellor |  |
| 2009 (ke-16) | Gabourey Sidibe | Precious | Precious Jones |  |
| 2009 (ke-16) | Meryl Streep | Julie & Julia | Julia Child |  |