Liga Konferensi Eropa UEFA 2021–2022
Babak Kualifikasi > Babak Kualifikasi Kedua

Pengundian untuk babak kualifikasi kedua diadakan pada 16 Juni 2021, 13:30 CEST.
Leg pertama dimainkan pada 20, 21 dan 22 Juli, dan leg kedua dimainkan pada 27 dan 29 Juli 2021.
Pemenang dari pertandingan tersebut maju ke babak kualifikasi ketiga dari jalur mereka masing-masing. Yang kalah tersingkir dari kompetisi Eropa untuk musim ini.
Jalur Juara
| Tim 1 | Agregat | Tim 2 | Leg 1 | Leg 2 |
| --- | --- | --- | --- | --- |
| Shamrock Rovers  | Bye | N/A | — | — |
| Teuta  | 3–2 |  Inter Club d'Escaldes | 0–2 | 3–0 (p.w.) |
| Riga  | 3–0 |  Shkëndija | 2–0 | 1–0 |
| Dinamo Tbilisi  | 2–7 |  Maccabi Haifa | 1–2 | 1–5 |
| HB Tórshavn  | 6–0 |  Budućnost Podgorica | 4–0 | 2–0 |
| Linfield  | 4–0 |  Borac Banja Luka | 4–0 | 0–0 |
| Shakhtyor Soligorsk  | 1–3 |  Fola Esch | 1–2 | 0–1 |
| Folgore  | 3–7 |  Hibernians | 1–3 | 2–4 |
| Prishtina  | 6–5 |  Connah's Quay Nomads | 4–1 | 2–4 |
| Valur  | 0–6 |  Bodø/Glimt | 0–3 | 0–3 |
Jalur Utama
| Tim 1 | Agregat | Tim 2 | Leg 1 | Leg 2 |
| --- | --- | --- | --- | --- |
| KuPS  | 5–4 |  Vorskla Poltava | 2–2 | 3–2 (p.w.) |
| FCSB  | 2–2 (3–5 a.p.) |  Shakhter Karagandy | 1–0 | 1–2 (p.w.) |
| Arda  | 0–6 |  Hapoel Be'er Sheva | 0–2 | 0–4 |
| Apollon Limassol  | 3–5 |  Žilina | 1–3 | 2–2 |
| Čukarički  | 2–0 |  Sumgayit | 0–0 | 2–0 |
| Sutjeska  | 1–3 |  Maccabi Tel Aviv | 0–0 | 1–3 |
| Astana  | 3–2 |  Aris Thessaloniki | 2–0 | 1–2 (p.w.) |
| Petrocub Hîncești  | 0–2 |  Sivasspor | 0–1 | 0–1 |
| AEL Limassol  | 2–0 |  Vllaznia | 1–0 | 1–0 |
| Sochi  | 7–2 |  Keşla | 3–0 | 4–2 |
| IF Elfsborg  | 9–0 |  Milsami Orhei | 4–0 | 5–0 |
| RFS  | 5–0 |  Puskás Akadémia | 3–0 | 2–0 |
| Dinamo Batumi  | 4–2 |  BATE Borisov | 0–1 | 4–1 |
| Partizan  | 3–0 |  DAC Dunajská Streda | 1–0 | 2–0 |
| Dundalk  | 4–3 |  FCI Levadia | 2–2 | 2–1 |
| Gżira United  | 0–3 |  Rijeka | 0–2 | 0–1 |
| Viktoria Plzeň  | 4–2 |  Dynamo Brest | 2–1 | 2–1 |
| Kauno Žalgiris  | 1–10 |  The New Saints | 0–5 | 1–5 |
| Domžale  | 2–1 |  Honka | 1–1 | 1–0 |
| CSKA Sofia  | 0–0 (3–1 a.p.) |  Liepāja | 0–0 | 0–0 (p.w.) |
| Shkupi  | 0–5 |  Santa Clara | 0–3 | 0–2 |
| Hibernian  | 5–1 |  FC Santa Coloma | 3–0 | 2–1 |
| Larne  | 3–2 |  AGF | 2–1 | 1–1 |
| Gent  | 4–2 |  Vålerenga | 4–0 | 0–2 |
| F91 Dudelange  | 0–4 |  Bohemians | 0–1 | 0–3 |
| Velež Mostar  | 2–2 (3–2 a.p.) |  AEK Athens | 2–1 | 0–1 (p.w.) |
| Qarabağ  | 1–0 |  Ashdod | 0–0 | 1–0 |
| Lokomotiv Plovdiv  | 1–1 (3–2 a.p.) |  Slovácko | 1–0 | 0–1 (p.w.) |
| Ararat Yerevan  | 5–7 |  Śląsk Wrocław | 2–4 | 3–3 |
| Laçi  | 1–0 |  Universitatea Craiova | 1–0 | 0–0 |
| Drita  | 2–3 |  Feyenoord | 0–0 | 2–3 |
| Basel  | 5–0 |  Partizani | 3–0 | 2–0 |
| Pogoń Szczecin  | 0–1 |  Osijek | 0–0 | 0–1 |
| Austria Wien  | 2–3 |  Breiðablik | 1–1 | 1–2 |
| Olimpija Ljubljana  | 1–1  (5–4 a.p.) |  Birkirkara | 1–0 | 0–1 (p.w.) |
| Hammarby IF  | 4–1 |  Maribor | 3–1 | 1–0 |
| Molde  | 3–2 |  Servette | 3–0 | 0–2 |
| Újpest  | 5–2 |  Vaduz | 2–1 | 3–1 |
| Sūduva  | 0–0  (3–4 a.p.) |  Raków Częstochowa | 0–0 | 0–0 (p.w.) |
| Spartak Trnava  | 1–1 (4–3 a.p.) |  Sepsi OSK | 0–0 | 1–1 (p.w.) |
| FH  | 1–6 |  Rosenborg | 0–2 | 1–4 |
| Copenhagen  | 9–1 |  Torpedo-BelAZ Zhodino | 4–1 | 5–0 |
| Panevėžys  | 0–2 |  Vojvodina | 0–1 | 0–1 |
| Hajduk Split  | 3–4 |  Tobol | 2–0 | 1–4 (p.w.) |
| Aberdeen  | 5–3 |  BK Häcken | 5–1 | 0–2 |
1 2  Urutan leg dibalik setelah undian awal.