מעצם
הערות שוליים

↑  מַעֲצֵם במילון מיקרוביולוגיה (תשנ"ה), באתר האקדמיה ללשון העברית
↑  Driscoll, M. C., Dobkin, C. S., & Alter, B. P., Gamma delta beta-thalassemia due to a de novo mutation deleting the 5'beta-globin gene activation-region hypersensitive sites., Proceedings of the National Academy of Sciences
1 2 3  Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A, Super-enhancers in the control of cell identity and disease., Cell
1 2 3  Andersson, R., Promoter or enhancer, what's the difference? Deconstruction of established distinctions and presentation of a unifying model., Bioessays
↑  Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lotado, M. A., Frampton, G. M., Sharp, P. A., Boyer, L. A., Young, R. A., & Jaenisch, R. ., Histone H3K27ac separates active from poised enhancers and predicts developmental state., Proceedings of the National Academy of Sciences
1 2  Ngan, C. Y., Wong, C. H., Tjong, H., Wang, W., Goldfeder, R. L., Choi, C., He, H., Gong, L., Lin, J., Urban, B., Chow, J., Li, M., Lim, J., Philip, V., Murray, S. A., Wang, H., & Wei, C., Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development., Nature Genetics
↑  Zhang, Y., Wong, C. H., Birnbaum, R. Y., Li, G., Favaro, R., Ngan, C. Y., Lim, J., Tai, E., Poh, H, M., Wong, E., Mulawadi, F, H., Sung, W., Nicolis, S., Ahituv, N., Ruan, Y., & Wei, C., Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations., Nature
↑  Jeong, Y., El-Jaick, K., Roessler, E., Muenke, M., & Epstein, D. J., A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers. ., Development
↑  Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A., Master transcription factors and mediator establish super-enhancers at key cell identity genes., Cell
↑  Anderson, E., Devenney, P. S., Hill, R. E., & Lettice, L. A., Mapping the Shh long-range regulatory domain., Development
↑  Bashkirova, E., & Lomvardas, S., Olfactory receptor genes make the case for inter-chromosomal interactions., Current opinion in genetics & development,
1 2  Bar Yaacov, R., Eshel, R., Farhi, E., Shemuluvich, F., Kaplan, T., & Birnbaum, R. Y., Functional characterization of the ZEB2 regulatory landscape.., Human molecular genetics.
↑  Merika, M., & Thanos, D.., Enhanceosomes., Current opinion in genetics & development
↑  Thanos, D., & Maniatis, T., Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome, Cell
1 2 3  Spitz, F., & Furlong, E. E., Transcription factors: from enhancer binding to developmental control., Nature reviews genetics
↑  Arnosti, D. N., & Kulkarni, M. M., Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?, Journal of cellular biochemistry
↑  Kulkarni, M. M., & Arnosti, D. N., Information display by transcriptional enhancers., Development
↑  Junion, G., Spivakov, M., Girardot, C., Braun, M., Gustafson, E. H., Birney, E., & Furlong, E. E.., A transcription factor collective defines cardiac cell fate and reflects lineage history., Cell
↑  Liberman, L. M., & Stathopoulos, A., Design flexibility in cis-regulatory control of gene expression: synthetic and comparative evidence., Developmental biology.
↑  Brown, C. D., Johnson, D. S., & Sidow, A. ., Functional architecture and evolution of transcriptional elements that drive gene coexpression. ., Science
↑  Zinzen, R. P., Girardot, C., Gagneur, J., Braun, M., & Furlong, E. E., Combinatorial binding predicts spatio-temporal cis-regulatory activity., Nature
↑  Kong, S., Bohl, D., Li, C., & Tuan, D., Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene., Molecular and cellular biology
1 2 3 4 5  Furlong, E. E., & Levine, M., Developmental enhancers and chromosome topology, Science
↑  Deng, W., Lee, J., Wang, H., Miller, J., Reik, A., Gregory, P. D., ... & Blobel, G. A., Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor., Cell
↑  Morcillo, P., Rosen, C., Baylies, M. K., & Dorsett, D., Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila., Genes & Development
↑  Dunn, T. M., Hahn, S., Ogden, S., & Schleif, R. F., An operator at-280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression., Proceedings of the National Academy of Sciences
↑  Splinter, E., Heath, H., Kooren, J., Palstra, R. J., Klous, P., Grosveld, F., Galjart, N., & de Laat, W., CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus., Genes & development
↑  Wendt, K. S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., Yahata, K., Imamoto, F., Aburatani, H., Nakao, M., Imamoto, N., Maeshima, K., Shirahige, K., & Peters, J., Cohesin mediates transcriptional insulation by CCCTC-binding factor., Nature
↑  Heist, T., Fukaya, T., & Levine, M., Large distances separate coregulated genes in living Drosophila embryos, Proceedings of the National Academy of Sciences
↑  Gu, B., Swigut, T., Spencley, A., Bauer, M. R., Chung, M., Meyer, T., & Wysocka, J., Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements., Science
↑  Cho, W. K., Spille, J. H., Hecht, M., Lee, C., Li, C., Grube, V., & Cisse, I. I., Mediator and RNA polymerase II clusters associate in transcription-dependent condensates., Science
↑  Sabari, B. R., Dall’Agnese, A., Boija, A., Klein, I. A., Coffey, E. L., Shrinivas, K., Abraham, B. J., Hannett, N. M., Zamudio, A. V., Manteiga, J, C., Li, C. H., Guo, Y. E., Day, D. S., Schuijers, J., Vasile, E., Malik, S., Hnisz, D., Lee, T. I., Cisse, I. I., Roeder, R. G., Sharp, P. A., Chakraborty, A. K., & Young, R. A., Coactivator condensation at super-enhancers links phase separation and gene control., Science
↑  Chong, S., Dugast-Darzacq, C., Liu, Z., Dong, P., Dailey, G. M., Cattoglio, C., Heckert, A., Banala, S., Lavis, L., Darzacq, X., & Tjian, R., Imaging dynamic and selective low-complexity domain interactions that control gene transcription., Science
↑  Göttgens, B., Barton, L. M., Gilbert, J. G., Bench, A. J., Sanchez, M. J., Bahn, S., Mistry, S., Grafham, D., McMurray, A., Vaudin, M., Amaya, E., Bently, D.R., & Green, A.R., Analysis of vertebrate SCL loci identifies conserved enhancers., Nature biotechnology
↑  Loots, G. G., Locksley, R. M., Blankespoor, C. M., Wang, Z. E., Miller, W., Rubin, E. M., & Frazer, K. A., Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons, Science
↑  Wong, E. S., Tan, S. Z., Garside, V., Vanwalleghem, G., Gaiti, F., Scott, E., McGlinn, E., Francois, M & Degnan, B. M., Early origin and deep conservation of enhancers in animals, BioRxiv
↑  Ruvinsky, I., & Ruvkun, G., Functional tests of enhancer conservation between distantly related species, Development
↑  Huang, W., Nevins, J. R., & Ohler, U., Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools, Genome biology
↑  Fisher, S., Grice, E. A., Vinton, R. M., Bessling, S. L., Urasaki, A., Kawakami, K., & McCallion, A. S, Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish., Nature protocols
↑  Pennacchio, L. A., Ahituv, N., Moses, A. M., Prabhakar, S., Nobrega, M. A., Shoukry, M., Minovitsky, S., Dubchak, I., Holt, A., Lewis, K. D., Plajzer-Frick, I., Akiyama, J., De Val, S., Afzal, V., Black, B. L., Couronne, O., Eisen, M. B., Visel, A., & Rubin, E. M., In vivo enhancer analysis of human conserved non-coding sequences, Nature
↑  Hakim, O., & Misteli, T., SnapShot: chromosome conformation capture, Cell
↑  de Wit, E., & De Laat, W., A decade of 3C technologies: insights into nuclear organization, Genes & development
↑  Dekker, J., Rippe, K., Dekker, M., & Kleckner, N., Capturing chromosome conformation, Science
↑  Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., De Wit, E., ... & De Laat, W., domains uncovered by chromosome conformation capture–on-chip (4C), Nature genetics
↑  Dostie, J., Richmond, T. A., Arnaout, R. A., Selzer, R. R., Lee, W. L., Honan, T. A., ... & Green, R. D., Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements., Genome research
↑  Lettice, L. A., Heaney, S. J., Purdie, L. A., Li, L., de Beer, P., Oostra, B. A., Goode, D.,Elgar, G., Hill, R. E., & de Graaff, E., A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly., Human molecular genetics
↑  Sagai, T., Hosoya, M., Mizushina, Y., Tamura, M., & Shiroishi, T., Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb, Development
↑  Kvon, E. Z., Kamneva, O. K., Melo, U. S., Barozzi, I., Osterwalder, M., Mannion, B. J., Tissieres, V., Pickle, C. S., Plajzer,-Frick, I., Lee, E. A., Kato, M., Garvin, T. H., Akiyama, J. A., Afzal, V., Lopez-Rios, J., Rubin, E. M., Dickle, D. E., Pennachio, L. A., & Visel, A., M., Dickle, D. E., Pennachio, L. A., & Visel, A. (2016). Progressive loss of function in a limb enhancer during snake evolution., Cell
↑  Chapuis, J., Hansmannel, F., Gistelinck, M., Mounier, A., Van Cauwenberghe, C., Kolen, K. V., Geller, F., Sottejeau, Y., Harold, D., Dourlen, P., Grenier-Boley, B., Kamatani, Y., Delepine, B., Demiautte, F., Zelenika, D., Zommer, N., Hamdane, M., Bellenguez, C., Dartigues, J. F., Hauw, J. J., Letronne, F., Ayral, A. M., Sleegers, K., Schellens, A., Broeck, L. V., Engleborghs, S., De Deyn, P. P., Vandnberghe, R., O'Donovan, M., Owen, M., Epelbaum, J., Mercken, M., Karran, E., Bantscheff, M., Drewes, G., Joberty, G., Campion, D., Octave, J. N., Berr, C., Lathrop, M., Callaerts, P., Mann, D., Williams, J., Buee, L., Dewachter, I., Van Broeckhoven, C., Amouyel, P., Moechars, D., Dermaut, B & Lambert, J. C, Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology., Molecular psychiatry
↑  Smemo, S., Campos, L. C., Moskowitz, I. P., Krieger, J. E., Pereira, A. C., & Nobrega, M. A., Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease, Human molecular genetics
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