אסף פרידלר
מאמרים נבחרים

Friedler A, Hansson LO, Veprintsev DB. Freund SMV, Rippin TM, Nikolova PV, Proctor MR, Rüdiger S and Fersht AR (2002) A peptide that binds and stabilises p53 core domain: chaperone strategy for rescue of oncogenic mutants, Proc. Natl. Acad. Sci. USA 99, 937-942
Hayouka Z, Rosenbluh J, Levin A, Loya S, Lebendiker M, Veprintsev DB, Kotler M, Hizi A, Loyter A and Friedler A (2007) “Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium”, Proc Natl Acad Sci USA, 104(20):8316-21
Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Dines M, Bronner V, Bravman T, Rudiger S and Friedler A (2008) “Molecular Basis of the Interaction Between the Anti-Apoptotic Bcl-2 Family Proteins and the Pro-Apoptotic Protein ASPP2”, Proc Natl Acad Sci USA, 105(34):12277-82
Katz C, Levy-Beladev L, Rotem-Bamberger S, Rito T, Rüdiger SG and Friedler A (2011) “Studying protein-protein interactions using peptide arrays”, Chem Soc Rev, 40(5):2131-45
Chandra K, Roy TK, Shalev DE, Loyter A, Gilon C, Gerber RB and Friedler A (2014) “A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage”, Angew Chem Int Ed Engl, 53(36):9450-5
Iosub-Amir A, Van Rosmalen M, Mayer G, Lebendiker M, Danieli T and Friedler A (2015) “Highly homologous proteins exert opposite biological activities by using different interaction interfaces”, Sci Rep, 5, 11629
Amartely H, David A, Shamir M, Lebendiker M, Izraeli S and Friedler A (2016) “Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein”, Chem Sci, 7(7), 4140-4147
Samarasimhareddy M, Mayer D, Metanis N, Veprintsev D, Hurevich M and Friedler A (2019) “A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins”, Org Biomol Chem, 17(42):9284-9290
Iosub-Amir A, Bai F, Sohn Y, Song L, Tamir S, Marjault H, Mayer G, Karmi O, Jennings P, Mittler R, Onuchic J, Friedler A and Nechushtai R (2019) “The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells” Chem Sci, 10, 665-673
Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, Friedler A and Veprintsev DB (2019) “Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation”, Nat Commun, 10(1):1261.
Mayer G, Shpilt Z, Bressler S, Marcu O, Schueler-Furman O, Tshuva EY and Friedler A (2020) “Targeting an interaction between two disordered domains using a designed peptide”, Chem Eur J, 26(45):10156
Joshi PN, Mervinetsky E, Solomon O, Chen YJ, Yitzchaik S and Friedler A (2022) “Electrochemical biosensors based on peptide-kinase interactions at the kinase docking site”, Biosens Bioelectron, 207:114177
Sohn YS, Losub-Amir A, Cardenas AE, Karmi O, Yahana MD, Gruman T, Rowland L, Marjault HB, Webb LJ, Mittler R, Elber R, Friedler A, Nechushtai R. (2022) A peptide-derived strategy for specifically targeting the mitochondria and ER of cancer cells: a new approach in fighting cancer. Chem Sci. 13(23):6929-6941.
Mayer G, Shpilt Z, Kowalski H, Tshuva EY, Friedler A. Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors.(2022) ACS Chem Biol. 17(7):1811-1823.