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Satchi R, Connors TA and Duncan R, PDEPT: Polymer-directed enzyme prodrug therapy. 1. HPMA copolymer-cathepsin B and PK1 as a model combination, British Journal of Cancer, 85(7), 1070-1076 (2001).
Satchi-Fainaro R, Hailu H, Davies JW, Summerford C and Duncan R, PDEPT: Polymer directed enzyme prodrug therapy. 2. HPMA copolymer-b-lactamase and HPMA copolymer-Cephalosporin-Doxorubicin as a model combination, Bioconjugate Chemistry, 14(4), 797-804 (2003).
Satchi-Fainaro R, Puder M, Davies J, Tran H, Sampson DA, Greene AK, Corfas G and Folkman J, Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470, Nature Medicine, 10(3), 255-261 (2004).
Satchi-Fainaro R, Mamluk R, Wang L, Short SM, Nagy JA, Feng D, Dvorak AM, Dvorak HF, Puder M, Mukhopadhyay D and Folkman J, Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin, Cancer Cell, 7(3), 251-261 (2005).
Miller K, Erez R, Segal E, Shabat D and Satchi-Fainaro R, Targeting bone metastases with bi-specific anticancer and anti-angiogenic polymer-alendronate-taxane conjugate, Angewandte Chemie-International Edition English 48(16), 2949 –2954 (2009).
Ofek P, Fischer W, Calderón M, Haag R and Satchi-Fainaro R, In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers, FASEB Journal, 24(9), 3122-3134 (2010).
Eldar-Boock A, Miller K, Sanchis J, Lupu R, Vicent MJ and Satchi-Fainaro R, Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel, Biomaterials, 32(15), 3862-3874 (2011).
Segal E, Pan H, Benayoun L, Kopečková P, Shaked Y, Kopeček J and Satchi-Fainaro R, Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances, Biomaterials, 32(19):4450-4463 (2011).
Miller K, Clementi C, Polyak D, Eldar-Boock A, Benayoun L, Barshack I, Shaked Y, Pasut G and Satchi-Fainaro R, Anti-angiogenic activity of polyethyleneglycol-based paclitaxel and alendronate for the treatment of breast cancer bone metastases, Biomaterials, 34(15): 3795–3806 (2013).
Ferber S, Baabur-Cohen H, Blau R, Epshtein Y and Satchi-Fainaro R, Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release, Cancer Letters, 352(1):81-89 (2014).
Redy-Keisar O, Kisin-Finfer E, Ferber S, Satchi-Fainaro R*, and Shabat D*, Synthesis and Use of QCy7-derived Modular Probes for Detection and Imaging of Biologically Relevant Analytes, Nature Protocols, 9(1), 27-36 (2014). *Corresponding authors.
Markovsky E, Baabur-Cohen H, Satchi-Fainaro R, Anticancer polymeric nanomedicine bearing synergistic drug combination is superior to a mixture of individually-conjugated drugs, Journal of Controlled Release, 187: 145–157 (2014). (Cover feature).
Scomparin A, Salmaso S, Eldar-Boock A, Ben-Shushan D, Ferber S, Tiram G, Shmeeda H, Landa-Rouben N, Leor J, Caliceti P, Gabizon A, Satchi-Fainaro R, A comparative study of folate receptor-targeted doxorubicin delivery systems: dosing regimens and therapeutic index, Journal of Controlled Release, 208 106-120 (2015).
Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, Aviel-Ronen S, Barshack I, Calderón M, Haag R and Satchi-Fainaro R, Identification of Dormancy-Associated MicroRNAs for the Design of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes, ACS Nano 10(2): 2028-2045 (2016).
Baabur-Cohen H, Vossen L, Rune Krüger H, Eldar-boock A, Yeini E, Landa-Rouben N, Tiram G, Wedepohl S, Markovsky E, Leor J, Calderón M and Satchi-Fainaro R, In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio, Journal of Controlled Release, 257:118-131 (2017).
Shatsberg Z, Zhang X, Ofek P, Malhotra S, Krivitsky A, Scomparin A, Tiram G, Calderón M, Haag R, Satchi-Fainaro R., Functionalized nanogels carrying an anticancer microRNA for glioblastoma therapy, Journal of Controlled Release, 239:159-68 (2016).
Markovsky E, Eldar-Boock A, Ben-Shushan D, Baabur-Cohen H, Yeini E, Many A, Aviel-Ronen S, Barshack I, Satchi-Fainaro R, Targeting NCAM-expressing neuroblastoma with polymeric precision nanomedicine, Journal of Controlled Release, 249:162-172 (2017).
Hananya N, Green O, Blau R, Satchi-Fainaro R*, Shabat D*, A Highly-Efficient Chemiluminescence Probe for Detection of Singlet Oxygen in Living Cells. Angew Chem Int Ed Engl. 138(40):13438-13446 (2017) *Co-corresponding authors.
Markovsky E*, Vax E*, Ben-Shushan D, Eldar-Boock A, Shukrun R, Yeini E, Barshack I, Caspi R, Harari-Steinberg O, Pode-Shakked N, Dekel B, Satchi-Fainaro R, Wilms' tumor NCAM-expressing cancer stem cells as potential therapeutic target for polymeric nanomedicine, Molecular Cancer Therapeutics, 16(11), 2462-72 (2017).
Gibori H, Eliyahu S, Krivitsky A, Ben-Shushan D, Epshtein Y, Ofek P, Lee JS, Ruppin E, Merquiol E, Blum G, and Satchi-Fainaro R, An amphiphilic polymeric nanocarrier bearing a synergistic combination of miR-34a-PLK1 siRNA for pancreatic cancer therapy, Nature Communications, in press (2017).
Ferber S*, Tiram G*, Sousa-Herves A*, Eldar-Boock A, Krivitsky A, Ofek P, Scomparin A, Yeini E, Vossen LI, Licha K, Grossman R, Ram Z, Henkin J, Ruppin E, Auslander N, Haag R, Calderón M and Satchi-Fainaro R, Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome. eLife, pii: e25281(2017).
Krivitsky A*, Polyak D*, Scomparin A*, Eliyahu S, Ofek P, Tiram G, Kalinski H, Avkin-Nachum S, Feiner Gracia N, Albertazzi L, Satchi-Fainaro R. Amphiphilic poly(α)glutamate polymeric micelles for systemic administration of siRNA to tumors. Nanomedicine 14(2):303-315, 2017
*equal contribution.