אנזים הגבלה
הערות שוליים

1 2  Murray NE (ביוני 2000). "Type I restriction systems: sophisticated molecular machines (a legacy of Bertani and Weigle)". Microbiol. Mol. Biol. Rev. 64 (2): 412–34. doi:10.1128/MMBR.64.2.412-434.2000. PMC 98998. PMID 10839821. {{cite journal}}:  (עזרה)
1 2  Bickle TA, Krüger DH (ביוני 1993). "Biology of DNA restriction". Microbiol. Rev. 57 (2): 434–50. PMC 372918. PMID 8336674. {{cite journal}}:  (עזרה)
1 2  Gigorescu A, Morvath M, Wilkosz PA, Chandrasekhar K, Rosenberg JM (2004). "The integration of recognition and cleavage: X-ray structures of pre-transition state complex, post-reactive complex, and the DNA-free endonuclease".  In Alfred M. Pingoud (ed.). Restriction Endonucleases (Nucleic Acids and Molecular Biology, Volume 14). Berlin: Springer. pp. 137–178. ISBN 3-540-20502-0.{{cite book}}:  תחזוקה - ציטוט: multiple names: authors list (link)
1 2 3 4  Pingoud A, Jeltsch A (בספטמבר 2001). "Structure and function of type II restriction endonucleases". Nucleic Acids Res. 29 (18): 3705–27. doi:10.1093/nar/29.18.3705. PMC 55916. PMID 11557805. {{cite journal}}:  (עזרה)
1 2  Dryden DT, Murray NE, Rao DN (בספטמבר 2001). "Nucleoside triphosphate-dependent restriction enzymes". Nucleic Acids Res. 29 (18): 3728–41. doi:10.1093/nar/29.18.3728. PMC 55918. PMID 11557806. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Meisel A, Bickle TA, Krüger DH, Schroeder C (בינואר 1992). "Type III restriction enzymes need two inversely oriented recognition sites for DNA cleavage". Nature. 355 (6359): 467–9. doi:10.1038/355467a0. PMID 1734285. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Kim YG, Cha J, Chandrasegaran S (בפברואר 1996). "Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain". Proc. Natl. Acad. Sci. U.S.A. 93 (3): 1156–60. doi:10.1073/pnas.93.3.1156. PMC 40048. PMID 8577732. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD (בספטמבר 2010). "Genome editing with engineered zinc finger nucleases". Nat. Rev. Genet. 11 (9): 636–46. doi:10.1038/nrg2842. PMID 20717154. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Townsend JA, Wright DA, Winfrey RJ, Fu F, Maeder ML, Joung JK, Voytas DF (במאי 2009). "High-frequency modification of plant genes using engineered zinc-finger nucleases". Nature. 459 (7245): 442–5. Bibcode:2009Natur.459..442T. doi:10.1038/nature07845. PMC 2743854. PMID 19404258. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Shukla VK, Doyon Y, Miller JC, DeKelver RC, Moehle EA, Worden SE, Mitchell JC, Arnold NL, Gopalan S, Meng X, Choi VM, Rock JM, Wu YY, Katibah GE, Zhifang G, McCaskill D, Simpson MA, Blakeslee B, Greenwalt SA, Butler HJ, Hinkley SJ, Zhang L, Rebar EJ, Gregory PD, Urnov FD (במאי 2009). "Precise genome modification in the crop species Zea mays using zinc-finger nucleases". Nature. 459 (7245): 437–41. Bibcode:2009Natur.459..437S. doi:10.1038/nature07992. PMID 19404259. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Ekker SC (2008). "Zinc finger-based knockout punches for zebrafish genes". Zebrafish. 5 (2): 121–3. doi:10.1089/zeb.2008.9988. PMC 2849655. PMID 18554175.
1 2  Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R (ביולי 2009). "Knockout rats via embryo microinjection of zinc-finger nucleases". Science. 325 (5939): 433. doi:10.1126/science.1172447. PMC 2831805. PMID 19628861. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Tovkach A, Zeevi V, Tzfira T (באוקטובר 2010). "Expression, purification and characterization of cloning-grade zinc finger nuclease". J Biotechnol. 151 (1): 1–8. doi:10.1016/j.jbiotec.2010.10.071. PMID 21029755. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Christian M, Cermak T, Doyle EL, Schmidt C, Zhang F, Hummel A, Bogdanove AJ, Voytas DF (באוקטובר 2010). "Targeting DNA double-strand breaks with TAL effector nucleases". Genetics. 186 (2): 757–61. doi:10.1534/genetics.110.120717. PMC 2942870. PMID 20660643. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
1 2  Li T, Huang S, Jiang WZ, Wright D, Spalding MH, Weeks DP, Yang B (באוגוסט 2010). "TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain". Nucleic Acids Res. 39 (1): 359–372. doi:10.1093/nar/gkq704. PMC 3017587. PMID 20699274. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Roberts RJ, Vincze T, Posfai J, Macelis D. (2007). "REBASE--enzymes and genes for DNA restriction and modification". Nucleic Acids Res. 35 (Database issue): D269–70. doi:10.1093/nar/gkl891. PMC 1899104. PMID 17202163.{{cite journal}}:  תחזוקה - ציטוט: multiple names: authors list (link)
↑  R.J Roberts, 1988, Nucl Acids Res. 16(suppl):271 From p.213 Molecular Cell Biology 4th Edition by Lodish, Berk, Zipursky, Matsudaira, Baltimore and Darnell.
1 2 3 4 5 6 7  Monty Krieger; Matthew P Scott; Matsudaira, Paul T.; Lodish, Harvey F.; Darnell, James E.; Lawrence Zipursky; Kaiser, Chris; Arnold Berk (2004). Molecular Cell Biology (5th ed.). New York: W.H. Freeman and Company. ISBN 0-7167-4366-3.{{cite book}}:  תחזוקה - ציטוט: multiple names: authors list (link)
↑  "Stu I from Streptomyces tubercidicus". Sigma-Aldrich. נבדק ב-2008-06-07.
↑  Shimotsu H, Takahashi H, Saito H (בנובמבר 1980). "A new site-specific endonuclease StuI from Streptomyces tubercidicus". Gene. 11 (3–4): 219–25. doi:10.1016/0378-1119(80)90062-1. PMID 6260571. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
| --- | --- |
בקרת זהויות :  NLI: 987007533913205171  LCCN: sh85113284 
המבנה של אנזים EcoRI (גדילי תכלת וירוק) הקשור ל-DNA דו גדילי (גדילים חומים). שני יוני מנגן בעלי תפקיד קטליטי (אחד בכל מונומר) מוצגים ככדורים סגולים והם סמוכים לאתרי החיתוך בDNA
מבנה קריסטלוגרפי של אנזים ההגבלה HindIII שהוא דימר (מופיע בירוק ותכלת) מצומד ל-DNA דו-גדילי (חום)