טטרה-הידרו-ביופטרין
הערות שוליים

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↑  Jarosław Całka The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons. Folia Histochemica et Cytobiologica. 44 (1): 3–12. PMID 16584085.
↑  J Schaub, S Däumling, H C Curtius, A Niederwieser, K Bartholomé, M Viscontini, B Schircks, and J H Bieri Tetrahydrobiopterin therapy of atypical phenylketonuria due to defective dihydrobiopterin biosynthesis. Arch. Dis. Child. 53 (8): 674–6. doi:10.1136/adc.53.8.674. PMC 1545051. PMID 708106.
↑  BioMarin Announces Kuvan® (sapropterin dihydrochloride) Patent Challenge Settlement
↑  Tetrahydrobiopterin Deficiency National Organization for Rare Disorders (NORD)
↑  What are common treatments for phenylketonuria (PKU)?  NICHD. 2013-08-23
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↑  Phenylketonuria Genetics Home Reference.
↑  Haberfeld, H, ed. (1 March 2017). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Kuvan 100 mg-Tabletten.
↑  GCH1 gene National Institutes of Health.
↑  Wu, Guoyao; Meininger, Cynthia J. (2009). "Nitric oxide and vascular insulin resistance". BioFactors. 35 (1): 21–7. doi:10.1002/biof.3. PMID 19319842.
↑  SEYMOUR KAUFMAN "A new cofactor required for the enzymatic conversion of phenylalanine to tyrosine". The Journal of Biological Chemistry. 230 (2): 931–9. PMID 13525410.
↑  B Thöny, G Auerbach, and N Blau Tetrahydrobiopterin biosynthesis, regeneration and functions.  Biochemical Journal. 347: 1–16. doi:10.1042/0264-6021:3470001. PMC 1220924. PMID 10727395.
↑  Kuzkaya, N.; Weissmann, N.; Harrison, D. G.; Dikalov, S. (2003). "Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols: Implications For Uncoupling Endothelial Nitric-Oxide Synthase". Journal of Biological Chemistry. 278 (25): 22546–54. doi:10.1074/jbc.M302227200. PMID 12692136.
↑  Muller-Delp, J. M. (2009). "Ascorbic acid and tetrahydrobiopterin: looking beyond nitric oxide bioavailability". Cardiovascular Research. 84 (2): 178–9. doi:10.1093/cvr/cvp307. PMID 19744948.
↑  Tommaso Gori, Jason M. Burstein, Sofia Ahmed, Steve E.S. Miner, Abdul Al-Hesayen, Susan Kelly, and John D. Parker Folic Acid Prevents Nitroglycerin-Induced Nitric Oxide Synthase Dysfunction and Nitrate Tolerance Circulation. 104 (10): 1119–1123. doi:10.1161/hc3501.095358. ISSN 0009-7322.
↑  Biotech BioMarin Initiates Phase 3b Study to Evaluate the Effects of Kuvan on Neurophychiatric Symptoms in Subjects with PKU BioMarin Pharmaceutical Inc. 17 August 2010.
↑  Burton, B.; Grant, M.; Feigenbaum, A.; Singh, R.; Hendren, R.; Siriwardena, K.; Phillips, J.; Sanchez-Valle, A.; Waisbren, S.; Gillis, J.; Prasad, S.; Merilainen, M.; Lang, W.; Zhang, C.; Yu, S.; Stahl, S. (2015). "A randomized, placebo-controlled, double-blind study of sapropterin to treat ADHD symptoms and executive function impairment in children and adults with sapropterin-responsive phenylketonuria". Molecular Genetics and Metabolism. 114 (3): 415–24. doi:10.1016/j.ymgme.2014.11.011. PMID 25533024.
↑  Fernell, Elisabeth; Watanabe, Yasuyoshi; Adolfsson, Ingrid; Tani, Yoshihiro; Bergström, Mats; Phd, Per Hartvig; Md, Anders Lilja; Phd., Anne-Liis von Knorring MD.; Phd., Christopher Gillberg MD.; Phd., Bengt Lángström (2008). "Possible effects of tetrahydrobiopterin treatment in six children with autism - clinical and positron emission tomography data: A pilot study". Developmental Medicine & Child Neurology. 39 (5): 313–8. doi:10.1111/j.1469-8749.1997.tb07437.x. PMID 9236697.
↑  Richard E. Frye, Lynne C. Huffman and Glen R. Elliot Tetrahydrobiopterin as a novel therapeutic intervention for autism eurotherapeutics. 7 (3): 241–9. doi:10.1016/j.nurt.2010.05.004. PMC 2908599. PMID 20643376.
↑  Channon, Keithm. (2004). "Tetrahydrobiopterin". Trends in Cardiovascular Medicine. 14 (8): 323–7. doi:10.1016/j.tcm.2004.10.003. PMID 15596110.
↑  Nicholas J. Alp, Shafi Mussa, Jeffrey Khoo, Shijie Cai, Tomasz Guzik, Andrew Jefferson, Nicky Goh, Kirk A. Rockett, and Keith M. Channon Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression Journal of Clinical Investigation. 112 (5): 725–35. doi:10.1172/JCI17786. PMC 182196. PMID 12952921.
↑  Khoo, J. P.; Zhao, L; Alp, N. J.; Bendall, J. K.; Nicoli, T; Rockett, K; Wilkins, M. R.; Channon, K. M. (2005). "Pivotal Role for Endothelial Tetrahydrobiopterin in Pulmonary Hypertension". Circulation. 111 (16): 2126–33. doi:10.1161/01.CIR.0000162470.26840.89. PMID 15824200.
↑  Colin Cunnington, MRCP, Tim Van Assche, PhD, Cheerag Shirodaria, MD, MRCP, Ilias Kylintireas, MD, Alistair C. Lindsay, DPhil, MRCP, Justin M. Lee, MD, MRCP, Charalambos Antoniades, MD, PhD, Marios Margaritis, MD, Regent Lee, MBBS, MS, Ruha Cerrato, MD, Mark J. Crabtree, PhD, Jane M. Francis, DCRR, DNM, Rana Sayeed, PhD, FRCS, Chandi Ratnatunga, FRCS, Ravi Pillai, FRCS, Robin P. Choudhury, DM, MRCP, Stefan Neubauer, MD, FRCP, FMedSci, and Keith M. Channon, MD, FRCP, FMedSci Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease Circulation. 125 (11): 1356–66. doi:10.1161/CIRCULATIONAHA.111.038919. PMC 5238935. PMID 22315282.