אונקוגן
הערות שוליים

↑  Becker WM, Kleinsmith LJ, Hardin J, Bertoni GP. The World of the Cell. 7th ed. San Francisco: Benjamin Cummings; 2008.
1 2  Cooper, G. M. (2000). The cell: a molecular approach 2nd Edition.
↑  Martin, G. S. (2001). The hunting of the Src. Nature reviews Molecular cell biology, 2(6), 467-475.
↑  Abelson, H. T., & Rabstein, L. S. (1970). Lymphosarcoma: virus-induced thymic-independent disease in mice. Cancer research, 30(8), 2213-2222.
↑  D. STEHELIN, H. E. VARMUS, J. M. BISHOP, P. K. VOGT, DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA, Nature 260, 1976-03, עמ' 170–173 doi: 10.1038/260170a0
↑  The Nobel Prize in Physiology or Medicine 1989, NobelPrize.org (באנגלית)
↑  Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Chapter 15, Signal-Transduction Pathways: An Introduction to Information Metabolism
↑  Sporn, M. B., & Roberts, A. B. (1985). Autocrine growth factors and cancer. Nature, 313(6005), 745-747.
↑  J. Liu, Triplex targeting of human PDGF-B (c-sis, proto-oncogene) promoter specifically inhibits factors binding and PDGF-B transcription, Nucleic Acids Research 29, 2001-02-01, עמ' 783–791 doi: 10.1093/nar/29.3.783
↑  Carl-Henrik Heldin, Bengt Westermark, Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor, Physiological Reviews 79, 1999-01-10, עמ' 1283–1316 doi: 10.1152/physrev.1999.79.4.1283
↑  E Zwick, J Bange, A Ullrich, Receptor tyrosine kinase signalling as a target for cancer intervention strategies., Endocrine-related cancer, 2001-09, עמ' 161–173 doi: 10.1677/erc.0.0080161
↑  Carlos L. Arteaga, Epidermal Growth Factor Receptor Dependence in Human Tumors: More Than Just Expression?, The Oncologist 7, 2002-08-15, עמ' 31–39 doi: 10.1634/theoncologist.7-suppl_4-31
↑  Andreas Gschwind, Oliver M. Fischer, Axel Ullrich, The discovery of receptor tyrosine kinases: targets for cancer therapy, Nature Reviews Cancer 4, 2004-05, עמ' 361–370 doi: 10.1038/nrc1360
↑  Vallar, L. (1996). Oncogenic role of heterotrimeric G proteins. Cancer surveys, 27, 325-338.
↑  Mitchell, P. J., & Tjian, R. (1989). Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science, 245(4916), 371-378.
↑  Darnell, J. E. (2002). Transcription factors as targets for cancer therapy. Nature Reviews Cancer, 2(10), 740-749.
↑  Green, Douglas R., Means to an end : apoptosis and other cell death mechanisms, Cold Spring Harbor Laboratory Press, 2011, ISBN 978-0-87969-887-4
↑  Brill, A., Torchinsky, A., Carp, H., & Toder, V. (1999). The role of apoptosis in normal and abnormal embryonic development. Journal of assisted reproduction and genetics, 16(10), 512-519.
↑  Belinda C. Baliga, Sharad Kumar, Role of Bcl-2 family of proteins in malignancy, Hematological Oncology 20, 2002, עמ' 63–74 doi: 10.1002/hon.685
↑  J ADAMS, S CORY, Bcl-2-regulated apoptosis: mechanism and therapeutic potential, Current Opinion in Immunology 19, 2007-10, עמ' 488–496 doi: 10.1016/j.coi.2007.05.004
↑  Hyunhee Do, Wanyeon Kim, Roles of Oncogenic Long Non-coding RNAs in Cancer Development, Genomics & Informatics 16, 2018-12-31, עמ' e18 doi: 10.5808/gi.2018.16.4.e18
↑  Heng Fan, Jian‑Hua Zhu, Xue‑Qing Yao, Knockdown of long non‑coding RNA PVT1 reverses multidrug resistance in colorectal cancer cells, Molecular Medicine Reports, 2018-04-20 doi: 10.3892/mmr.2018.8907
↑  Qi Yang, Yang Yu, Ziqian Sun, Yuan Pan, Long non-coding RNA PVT1 promotes cell proliferation and invasion through regulating miR-133a in ovarian cancer, Biomedicine & Pharmacotherapy 106, 2018-10, עמ' 61–67 doi: 10.1016/j.biopha.2018.06.112
↑  J.Michael Bishop, Molecular themes in oncogenesis, Cell 64, 1991-01, עמ' 235–248 doi: 10.1016/0092-8674(91)90636-d
↑  Hobbs, G. A., Der, C. J., & Rossman, K. L. (2016). RAS isoforms and mutations in cancer at a glance. Journal of cell science, 129(7), 1287-1292.
↑  Alt, F. W., Kellems, R. E., Bertino, J. R., & Schimke, R. T. (1978). Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. Journal of Biological Chemistry, 253(5), 1357-1370.
↑  Brison, O. (1993). Gene amplification and tumor progression. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1155(1), 25-41.
↑  Brunangelo Falini, David Y. Mason, Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry, Blood 99, 2002-01-15, עמ' 409–426 doi: 10.1182/blood.v99.2.409
↑  Peter C. Nowell, Discovery of the Philadelphia chromosome: a personal perspective, Journal of Clinical Investigation 117, 2007-08-01, עמ' 2033–2035 doi: 10.1172/jci31771
| --- | --- |
בקרת זהויות :  NDL: 01234791  NKC: ph191232 
צביעה אימונו היסטוכימית לאונקוגן ErbB2 בריקמה של סרטן השד
שלושת המנגנונים המובילים להפעלה של אונקוגן. משמאל לימין: מוטציה, שכפול גנים וארגון מחדש של הכרומוזום.