רפאל משולם
הערות שוליים

↑  פרופ' רפאל משולם מסכם קריירה: "המחקר בישראל היה תענוג גדול", באתר ‏מאקו‏, 29 ביולי 2022
↑  תואר דוקטור הוענק לראשונה במכון וייצמן, הצופה, 25 בפברואר 1959
↑  מינויים והעלאות במכון ווייצמן, הצופה, 13 ביוני 1966
↑  העלאות ומינויים באוניברסיטה, מעריב, 5 בדצמבר 1966
↑  מענק לחוקר מרכיבי החשיש, דבר, 26 במרץ 1967
↑  העלאות באוניברסיטה העברית, על המשמר, 24 ביוני 1968
↑  פרופ' רפאל משולם נבחר לרקטור האוניברסיטה העברית, דבר, 18 במאי 1979
↑  פרסום נישואין, לתל אביב יפו והמחוז, הצופה, 24 ביולי 1955
1 2  מבריחים מספקים חומר למדענים, על המשמר, 29 באפריל 1964
↑  R. Mechoulam and Y. Shvo. The structure of cannabidiol. Tetrahedron, 19, 2073-2078 (1963).
↑  Y. Gaoni and R. Mechoulam. Isolation, structure and partial synthesis of an active constituent of hashish. J. Amer. Chem. Soc., 86, 1646-1647 (1964).
↑  1. R. Mechoulam. Marihuana chemistry. Review. Science, 168, 1159- 1166 (1970).
↑  R. Mechoulam, P. Braun and Y. Gaoni. A stereospecific synthesis of (-)-Δ1 and (-)-Δ6-tetrahydrocannabinols. J. Amer. Chem. Soc., 89, 4552-4554 (1967).
↑  מדען ישראלי גילה את הנוסחה המדעית של הסם המשכר וגילויו עורר הדים בארצות הברית, מעריב, 25 באוגוסט 1967
↑  R. Mechoulam, P. Braun and Y. Gaoni. Syntheses of Δ1-THC and related cannabinoids. J. Am. Chem. Soc., 94, 6159-6165 (1972).
↑  Z. Ben-Zvi, R. Mechoulam and S. Burstein. Identification through synthesis of an active Δ-1(6)-tetrahydrocannabinol metabolite. J. Am. Chem. Soc., 92, 3468-3469 (1970).
↑ J.L.G. Nilsson, I.M. Nilsson, S. Agurell, Z. Ben-Zvi and R. Mechoulam. Synthesis of a potential urinary THC metabolite. Acta Pharm. Suec., 9, 215-220 (1972).
R. Mechoulam, H. Varconi, Z. Ben-Zvi, H. Edery and Y. Grunfeld. Synthesis and biological activity of five tetrahydrocannabinol metabolites. J. Am. Chem. Soc., 94, 7930-7931 (1972).
R. Mechoulam, Z. Ben-Zvi, S. Agurell, I.M. Nilsson, J.L.G. Nilsson, H. Edery and Y. Grunfeld. Δ6-Tetrahydrocannabinol-7-oic acid, a urinary Δ6-THC metabolite: isolation and synthesis. Experientia, 29, 1193-1195 (1973).
↑  F. Taura, S. Morimoto, Y. Shoyama and R. Mechoulam. First direct evidence for the mechanism of Δ1-tetrahydrocannabinolic acid biosynthesis. J. Amer. Chem. Soc. 117, 9766-9767 (1995).
↑  לסקירה מוקדמת ראו R. Mechoulam, N.K. McCallum and S. Burstein. Recent advances in the chemistry and biochemistry of cannabis. Chem. Reviews 76, 75-112 (1976).
↑  R. Mechoulam, N. Lander, T.H. Varkony, I. Kimmel, O. Becker, Z. Ben-Zvi, H. Edery and G. Porath. Stereochemical requirements for cannabinoid activity. J. Med. Chem., 23, 1068-1072 (1980).
↑  I. Tamir, R. Mechoulam and A.Y. Meyer. Cannabidiol and Phenytoin: A structural comparison. J. Med. Chem., 23, 220-223 (1980).
↑ J.R. Leite, E.A. Carlini, N. Lander and R. Mechoulam. Anticonvulsant effect of (-) and (+) isomers of CBD and their dimethyl heptyl homologs. Pharmacol., 124, 141-146 (1982).
P. Consroe, M.A.C. Benedito, J.R. Leite, E.A. Carlini and R. Mechoulam. Effect of CBD on behavior seizures caused by convulsant drugs or current in mice. Eur. J. Pharmacol., 83, 293-298 (1982).
↑  J.M. Cunha, E.A. Carlini, A.E. Pereira, O.L. Ramos, G. Pimentel, R. Gagliardi, E.L. Sanvito, N. Lander and R. Mechoulam. Chronic administration of CBD to healthy volunteers and epileptic patients. Pharmacologia, 21, 175-185 (1980).
↑  F. S. Guimaraes, J.C. de Aquiar, R. Mechoulam and A. Breuer. Anxiolytic effect of cannabidiol derivatives in the elevated plus-maze. General Pharmacology 25, 161-164 (1994).
↑  L.Weiss, M.Zeira, S.Reich, S. Slavin, I. Raz, R.Mechoulam, R. Gallily. Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Neuropharmacol. 54, 244-249 (2008).
↑  D. McHugh, C. Tanner, R. Mechoulam, R. G. Pertwee, R. A. Ross. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids
and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Mol. Pharmacol. 73, 441-450 (2008).
↑  E.Murillo-Rodriguez, D.Millan-Aldaco, M. Palomero-Rivero, O. Prospero-Garcia, R. Mechoulam, R.Drucker-Colin. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Letters, 580, 4337-4345 (2006).
↑ L. Weiss, M. Zeira, S.Reich, M.Har-Noy, R. Mechoulam, S.Slavin, R.Gallily. Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmun. 39, 143-151 (2006).
Y. Dagon, Y. Avraham, G. Link, O. Zolotarev, R. Mechoulam, E.M Berry. The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells. Neurobiol Dis. 27, 174-181 (2007).
↑  A.M. Malfait, R. Gallily, P.F. Sumariwalla, A.S. Malik, E. Andreakos, R. Mechoulam, M. Feldmann. The non-psychoactive cannabis-constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc. Natl. Acad. Sci (USA) 97, 9561-9566 (2000).
↑  A. Abrahamov, A. Abrahamov and R. Mechoulam. An efficient new cannabinoid antiemetic in pediatric oncology. Life Sciences 56, 2097-2102 (1995).
↑  I. Wirguin, R. Mechoulam, A. Breuer, E. Schezen, J. Weidenfeld and T. Brenner. Suppression of experimental autoimmune encephalomyelitis by cannabinoids. Immunopharm. 28, 209-214 (1994).
↑ R. Mechoulam, J.J. Feigenbaum, N. Lander, M. Segal, T.U.C. Jarbe, A.J. Hiltunen and P. Consroe. Enantiomeric cannabinoids: stereospecificity of psychotropic activity. Experientia 44, 762-764 (1988).
P.J. Little, D.R. Compton, R. Mechoulam and B. Martin. Stereo- chemical effects of 11-OH-delta-8-THC-dimethylheptyl in mice and dogs. Pharmacol. Biochem. Behavior 32, 661-666 (1989).
T.U.C. Jarbe, A.J. Hiltunen and R. Mechoulam. Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-OH-delta-8-tetrahydrocannabinol in rats and pigeons. J. Pharmacol. Exper. Ther. 250, 1000-1005 (1989).
↑  W.A. Devane, L. Hanus, A. Breuer, R.G. Pertwee, L.A. Stevenson, G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger and R. Mechoulam. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992).
↑ E. Fride and R. Mechoulam. Pharmacological activity of the cannabinoid agonist anandamide, a brain constituent. Eur. J. Pharmacol. 231, 313-314 (1993).
Z. Vogel, J. Barg, R. Levy, D. Saya, E. Heldman and R. Mechoulam. Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. J. Neurochem. 61, 352-355 (1993).
J. Weidenfeld, S. Feldman and R. Mechoulam. The effect of the brain constituent anandamide, a cannabinoid receptor agonist, on the hypothalamo-pituitary-adrenal axis in the rat. Neuroendoc- rinology 59, 110-112 (1994).
P.B. Smith, D.R. Compton, S.P. Welch, R.K. Razdan, R. Mechoulam and B.R. Martin. The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice. J. Pharmacol. Exp. Ther. 270, 219-227 (1994).
↑  R. Mechoulam, S. Ben-Shabat, L. Hanus, M. Ligumsky, N.E. Kaminski, A.R. Schatz, A. Gopher, S. Almog, B.R. Martin, D.R. Compton, R.G. Pertwee, G. Griffin, M. Bayewitch, J. Barg and Z. Vogel. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50, 83-90 (1995).
↑ לסקירות ראו
R. Mechoulam, E. Fride and V. Di Marzo. Endocannabinoids. Eur. J. Pharmacol. 359, 1-18 (1998).
A.C. Howlett, F. Barth, T.I. Bonner, G.Cabral, P. Casellas, W.A. Devane, C.C. Felder, M. Herkenham, K. Mackie, B.R. Martin, R. Mechoulam and R.G. Pertwee. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol. Rev. 54, 161-202, 2002.
בפרקים שבספר Mechoulam, Editor, Cannabinoids as Therapeutics. Birkhauser Verlag, Basel, 2005. Author – with L.Hanus - of chapter 1, pp. 23-46. "Cannabinoid chemistry, an overview".
1 2  G.Milman, Y.Maor, S.Abu-Lafi, M.Horowitz, R.Gallily, S.Batkai, F-M. Mo, L. Offertaler, P. Pacher, G. Kunos, R. Mechoulam. N-Arachidonoyl L-serine, a novel endocannabinoid-like brain constituent with vasodilatory properties. PNAS, 103, 2428-2433 (2006).
↑ D. Panikashvili, C. Simeonidou, S. Ben-Shabat, L. Hanus, A. Breuer, R. Mechoulam and E. Shohami. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature413, 527-531 (2001).
D. Panikashvili, R. Mechoulam, S. M. Beni, A. Alexandrovitch and E. Shohami. CB1 cannabinoid receptors are involved in neuroprotection via NF-kB inhibition. J. Cerebral Blood Flow Metabolism 25, 477-484 (2005).
D.Panikashvili, N.A.Shein, R.Mechoulam, V.Trembovler, R.Kohen, A.Alexandrovitch, E.Shohami. The endocannabinoid 2-AG protects the blood brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. Neurobiol. Disease, 22, 257-264, 2006.
M.Garcia-Arencibia, S.Gonzalez, E. de Lago, J.A.Ramos, R.Mechoulam, J.Fernandez-Ruiz, Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Research 1134, 162-170 (2007).
R. Durst, H. Danenberg, R. Gallily, R. Mechoulam, K. Meir, E. Grad, E., R. Beeri, T. Pugatsch, E.Tarsish, C. Lotan. Cannabidiol, a non-psychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury. Am J Physiol Heart Circ Physiol. 293, H3602-H3607 (2007).
↑ R. Mechoulam, E.Fride, L.Hanus, T. Sheskin, T.Bisogno, V.Di Marzo, M. Bayewitch and Z. Vogel. Anandamide may mediate sleep induction. Nature, 389, 25-26 (1997).
E.Murillo-Rodriguez, D.Millan-Aldaco, M. Palomero-Rivero, O. Prospero-Garcia, R. Mechoulam, R.Drucker-Colin. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Letters, 580, 4337-4345 (2006).
↑ N.M. Kogan, C. Blasquez, L.Alvarez, R.Gallily, M. Schlesinger, M.Guzman, R. Mechoulam. A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells. Mol. Pharmacol. 70, 51-59 (2006).
T.Aguado, A. Carracedo, B. Julien, G. Velasco, G. Milman, R. Mechoulam, L. Alvarez, M. Guzman, I. Galve-Roperh. Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis. J. Biol. Chem. 282, 6854-6862 (2007).
1 2  P.F. Sumariwalla, R. Gallily, S. Tchilibon, E. Fride, R. Mechoulam and M. Feldmann. A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with anti-inflammatory properties in murine collagen-induced arthritis. Arthritis & Rheumatism 50, 985-998 (2004).
↑  E. Fride, Y. Ginzburg, A. Breuer, T. Bisogno, V. Di Marzo and R. Mechoulam. Critical role of the endogenous cannabinoid system in mouse pup suckling and growth. Eur. J. Pharmacol. 419, 207-214 (2001).
↑  J.Tam, O.Ofek, E.Fride, C.Ledent, Y. Gabet, R. Muller, A.Zimmer, K.Mackie, R. Mechoulam, E. Shohami, I. Bab. Involvement of neuronal cannabinoid receptor, CB1, in regulation of bone mass and bone remodeling. Mol. Pharmacol. 70, 4337-4345 (2006).
↑ L.A. Parker, M. Kwiatkowska, P. Burton and R. Mechoulam. Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacol. 171, 156-161 (2004).
M. Kwiatkowska, L.A. Parker, P. Burton and R. Mechoulam. A comparative analysis of the potential cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew). Psychopharmacol. 174, 254-259 (2004).
D. McHugh, C. Tanner, R. Mechoulam, R. G. Pertwee, R. A. Ross. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Mol. Pharmacol. 73, 441-450 (2008).
↑ N. Kogan, R. Rabinowitz, P. Levi, D. Gibson, P. Sandor, M. Schlesinger and R. Mechoulam. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. J. Med. Chem. 47, 3800-3806 (2004).
N.M. Kogan, M.Schlesinger, E, Priel, R.Rabinowitz, E. Berenshtein, M.Chevion, R.Mechoulam. HU-331, a novel cannabinoid-based anticancer topoisomerase inhibitor. Molecular Cancer Therapeutics 6, 173-183 (2007).
↑  Marion Fischel, The 50 most influential Jews of 2014, Jerusalem Post
↑  בן-גוריון: תואר כבוד הוענק לפרופ' רפאל משולם מגלה ה-THC, באתר מגזין קנאביס
↑  כרמלה מנשה, פרס א.מ.ת יוענק לשחקנית ליא קניג, באתר רשת ב', 10 ביולי 2012
↑  הזוכים בפרס רוטשילד לשנת 2012, אתר יד הנדיב
| --- | --- |
בקרת זהויות :  NLI: 987007265101005171  BnF: cb12911225b (data)  CiNii: DA08389078  GND: 130347817  ISNI: 0000 0001 1691 0752  LCCN: n85063925  NKC: xx0283446  NTA: 073912093  ORCID: 0000-0002-6122-5698  RERO: 02-A003578837  SUDOC: 09628191X  VIAF: 97368809   WorldCat (עם VIAF): 97368809