מתילציה
הערות שוליים

↑  מִתּוּל במילון כימיה אורגנית (תשנ"ב), באתר האקדמיה ללשון העברית
↑  Mattei AL, Bailly N, Meissner A., DNA methylation: a historical perspective
↑  Johnson, T.B., & Coghill, R.D, RESEARCHES ON PYRIMIDINES. C111. ON PYRIMIDINES. C111. THE DISCOVERY OF 5-METHYL-CYTOSINE IN TUBERCULINIC ACID, THE NUCLEIC ACID OF THE TUBERCLE BACILLUS1
↑  HOTCHKISS RD., The quantitative separation of purines, pyrimidines, and nucleosides
↑  Holliday R & Pugh JE, DNA modification mechanisms and gene activity during development
↑  Riggs AD., X chromosome inactivation, differentiation, and DNA methylation revisite
↑  Tost, J., DNA Methylation: An Introduction to the Biology and the Disease-Associated Changes of a Promising Biomarker.
1 2 3  Lander, E. S et al, Initial sequencing and analysis of the human genome.
↑  Dunn, D. B., & Smith, J. D., The occurrence of 6-methylaminopurine in deoxyribonucleic acids
↑  Vanyushin, B. F., Tkacheva, S. G., & Belozersky, A. N., Rare bases in animal DNA
↑  Ehrlich, M., el al, DNA methylation in thermophilic bacteria: N4-methylcytosine, 5-methylcytosin and N6-methyladenine
↑  Feng, S. et al, Conservation and divergence of methylation patterning in plants and animals
↑  Zemach, A. eat al, Genome-wide evolutionary analysis of eukaryotic DNA methylation.
↑  Kuo, M. T., Mandel, J. L., & Chambon, P., DNA methylation: correlation with DNase I sensitivity of chicken ovalbumin and conalbumin chromatin.
↑  Jones P. A., Functions of DNA methylation: islands, start sites, gene bodies and beyond.
↑  Lev Maor, G., Yearim, A., & Ast, G., The alternative role of DNA methylation in splicing regulation
↑  Maunakea, A. K. et al, Conserved role of intragenic DNA methylation in regulating alternative promoters.
↑  Dahlet, T., Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity.
↑  Zhou, W. et al, DNA methylation enables transposable element-driven genome expansion.
↑  Choy, M. K., Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated
↑  Okano, M. et al, DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
↑  Aapola, U. et al, Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
↑  Bird A.P, CpG-rich islands and the function of DNA methylation.
↑  Gardiner-Garden, M., & Frommer, M., CpG islands in vertebrate genomes.
↑  Illingworth, R. S. et al, Orphan CpG islands identify numerous conserved promoters in the mammalian genome.
1 2  Saxonov, S., Berg, P., & Brutlag, D. L., A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters.
↑  Cedar, H., & Razin, A., Annotating the genome by DNA methylation
↑  Seisenberger, S., Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers.
↑  Cedar, H., & Bergman, Y., Programming of DNA methylation patterns.
↑  Jackson-Grusby, L. et al, Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.
↑  Li, E., Bestor, T. H., & Jaenisch, R., Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
↑  Beard, C., Li, E., & Jaenisch, R., Loss of methylation activates Xist in somatic but not in embryonic cells.
↑  Li, E., Beard, C., & Jaenisch, R., Role for DNA methylation in genomic imprinting.
↑  מנגנון המתילציה משתיק את הגנים שאינם רלוונטיים לפעילות של תא מסוים באמצעות חיבור של קבוצת מתיל (אטום פחמן ושלושה אטומי מימן) לגנים אלה
↑   גדעון לב, חוקרים מצאו איפה כתוב בדנ"א עד מתי תוכלו לחיות, באתר הארץ, 13 ביוני 2024
↑   גדעון לב, חוקרים מצאו איפה כתוב בדנ"א עד מתי תוכלו לחיות, באתר הארץ, 13 ביוני 2024
↑  Wang, Yb., & Jia, S., Degrees make all the difference: the multifunctionality of histone H4 lysine 20 methylation.
↑  Blanc, R. S., & Richard, S., Arginine Methylation: The Coming of Age.
↑  Rahhal, R., & Seto, E., Emerging roles of histone modifications and HDACs in RNA splicing.
1 2  Zhang, Y., & Reinberg, D., Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.
↑  Zhou, Y. et al, Principles of RNA methylation and their implications for biology and medicine
↑  Roundtree, I. A. et al, Dynamic RNA Modifications in Gene Expression Regulation.
↑  Han, M. et al, Abnormality of m6A mRNA Methylation Is Involved in Alzheimer's Disease.
↑  Liu, J. et al, A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
↑  Robertson K. D., DNA methylation and human disease.
↑  Zachariah, R. M., & Rastegar, M., Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research.
↑  Diaz-Meyer, N. et al, Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome.
↑  Schmidt, J. V., Levorse, J. M., & Tilghman, S. M., Enhancer competition between H19 and Igf2 does not mediate their imprinting.
↑  Maher, E. R., & Reik, W., Beckwith-Wiedemann syndrome: imprinting in clusters revisited.
↑  Tatton-Brown, K., & Weksberg, R., Molecular mechanisms of childhood overgrowth.
↑  Tatton-Brown, K. et al, Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.
↑  Lui, J. C. et al, Ezh2 Mutations Found in the Weaver Overgrowth Syndrome Cause a Partial Loss of H3K27 Histone Methyltransferase Activity.
↑  Wang, Y. P., & Lei, Q. Y., Metabolic recoding of epigenetics in cancer.
↑  Gonzalo S., Epigenetic alterations in aging.
↑  Esteller M., Epigenetics provides a new generation of oncogenes and tumour-suppressor genes.
↑  Lund, G. et al, DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E.
↑  Castro, R. et al, Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease.
↑  Crawford, D. C., Acuña, J. M., & Sherman, S. L., FMR1 and the fragile X syndrome: human genome epidemiology review.
↑  Oberlé, I. et al, Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome.
↑  Klippel J. H., Systemic lupus erythematosus: demographics, prognosis, and outcome.
↑  Richardson, B. et al, Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.
↑  Ehrlich M., The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease.
| --- | --- |
בקרת זהויות :  NLI: 987007529312705171  LCCN: sh85084424  LNB: 000297597  NDL: 00567625 
איור 3: דפוס מתילציה באיי CpG.
איור 4: מבנה חלבוני ההיסטון בנוקלאוזום