Mdm2
הערות שוליים

1 2 3  GRCh38: Ensembl גרסה 89: ENSG00000135679 - Ensembl, מאי 2017
1 2 3  GRCm38: Ensembl גרסה 89: ENSMUSG00000020184 - Ensembl, מאי 2017
↑  "Human PubMed Reference:".
↑  "Mouse PubMed Reference:".
↑  Ito, Akihiro; Kawaguchi Yoshiharu; Lai Chun-Hsiang; Kovacs Jeffrey J; Higashimoto Yuichiro; Appella Ettore; Yao Tso-Pang (בנובמבר 2002). "MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation". EMBO J. 21 (22): 6236–45. doi:10.1093/emboj/cdf616. PMC 137207. PMID 12426395. {{cite journal}}:  (עזרה)
↑  Ofir-Rosenfeld, Yaara; Boggs Kristy; Michael Dan; Kastan Michael B; Oren Moshe (באוקטובר 2008). "Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26". Mol. Cell. 32 (2): 180–9. doi:10.1016/j.molcel.2008.08.031. PMC 2587494. PMID 18951086. {{cite journal}}:  (עזרה)
↑  Ochocka, Anna Maria; Kampanis Petros; Nicol Samantha; Allende-Vega Nerea; Cox Miranda; Marcar Lynnette; Milne Diane; Fuller-Pace Frances; Meek David (בפברואר 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Lett. 583 (4): 621–6. doi:10.1016/j.febslet.2009.01.009. PMID 19166840. {{cite journal}}:  (עזרה)
↑  Zhao, Lili; Samuels Tina; Winckler Sarah; Korgaonkar Chandrashekhar; Tompkins Van; Horne Mary C; Quelle Dawn E (בינואר 2003). "Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways". Mol. Cancer Res. 1 (3): 195–206. PMID 12556559. {{cite journal}}:  (עזרה)
↑  Legube, Gaëlle; Linares Laetitia K; Lemercier Claudie; Scheffner Martin; Khochbin Saadi; Trouche Didier (באפריל 2002). "Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation". EMBO J. England. 21 (7): 1704–12. doi:10.1093/emboj/21.7.1704. PMC 125958. PMID 11927554. {{cite journal}}:  (עזרה)
1 2 3  Dai, Mu-Shui; Sun Xiao-Xin; Lu Hua (ביולי 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–76. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907. {{cite journal}}:  (עזרה)
1 2 3  Ivanchuk, Stacey M; Mondal Soma; Rutka James T (ביוני 2008). "p14ARF interacts with DAXX: effects on HDM2 and p53". Cell Cycle. 7 (12): 1836–50. doi:10.4161/cc.7.12.6025. PMID 18583933. {{cite journal}}:  (עזרה)
↑  Zhang, Zhuo; Zhang Ruiwen (במרץ 2008). "Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation". EMBO J. 27 (6): 852–64. doi:10.1038/emboj.2008.25. PMC 2265109. PMID 18309296. {{cite journal}}:  (עזרה)
↑  Sehat, Bita; Andersson Sandra; Girnita Leonard; Larsson Olle (ביולי 2008). "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis". Cancer Res. 68 (14): 5669–77. doi:10.1158/0008-5472.CAN-07-6364. PMID 18632619. {{cite journal}}:  (עזרה)
↑  Chang, Lufen; Zhou Bingsen; Hu Shuya; Guo Robin; Liu Xiyong; Jones Stephen N; Yen Yun (בנובמבר 2008). "ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18519–24. doi:10.1073/pnas.0803313105. PMC 2587585. PMID 19015526. {{cite journal}}:  (עזרה)
↑  Brenkman, Arjan B; de Keizer Peter L J; van den Broek Niels J F; Jochemsen A G; Burgering Boudewijn M Th (2008).  Cookson, Mark R. (ed.). "Mdm2 induces mono-ubiquitination of FOXO4". PLoS ONE. 3 (7): e2819. doi:10.1371/journal.pone.0002819. PMC 2475507. PMID 18665269.
1 2 3  Zhang, Yanping; Wolf Gabrielle White; Bhat Krishna; Jin Aiwen; Allio Theresa; Burkhart William A; Xiong Yue (בדצמבר 2003). "Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway". Mol. Cell. Biol. 23 (23): 8902–12. doi:10.1128/MCB.23.23.8902-8912.2003. PMC 262682. PMID 14612427. {{cite journal}}:  (עזרה)
↑  Marechal, V; Elenbaas B; Piette J; Nicolas J C; Levine A J (בנובמבר 1994). "The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes". Mol. Cell. Biol. 14 (11): 7414–20. PMC 359276. PMID 7935455. {{cite journal}}:  (עזרה)
↑  Goldberg, Zehavit; Vogt Sionov Ronit; Berger Michael; Zwang Yaara; Perets Ruth; Van Etten Richard A; Oren Moshe; Taya Yoichi; Haupt Ygal (ביולי 2002). "Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation". EMBO J. 21 (14): 3715–27. doi:10.1093/emboj/cdf384. PMC 125401. PMID 12110584. {{cite journal}}:  (עזרה)
↑  Chen, Deng; Zhang Jianbing; Li Mao; Rayburn Elizabeth R; Wang Hui; Zhang Ruiwen (בפברואר 2009). "RYBP stabilizes p53 by modulating MDM2". EMBO Rep. 10 (2): 166–72. doi:10.1038/embor.2008.231. PMC 2637313. PMID 19098711. {{cite journal}}:  (עזרה)
↑  Chen, Delin; Li Muyang; Luo Jianyuan; Gu Wei (באפריל 2003). "Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function". J. Biol. Chem. 278 (16): 13595–8. doi:10.1074/jbc.C200694200. PMID 12606552. {{cite journal}}:  (עזרה)
↑  Ravi, R; Mookerjee B; Bhujwalla Z M; Sutter C H; Artemov D; Zeng Q; Dillehay L E; Madan A; Semenza G L; Bedi A (בינואר 2000). "Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha". Genes Dev. 14 (1): 34–44. PMC 316350. PMID 10640274. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Jin, Yetao; Zeng Shelya X; Dai Mu-Shui; Yang Xiang-Jiao; Lu Hua (באוגוסט 2002). "MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation". J. Biol. Chem. 277 (34): 30838–43. doi:10.1074/jbc.M204078200. PMID 12068014. {{cite journal}}:  (עזרה)
↑  Léveillard, T; Wasylyk B (בדצמבר 1997). "The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter". J. Biol. Chem. 272 (49): 30651–61. doi:10.1074/jbc.272.49.30651. PMID 9388200. {{cite journal}}:  (עזרה)
↑  Thut, C J; Goodrich J A; Tjian R (באוגוסט 1997). "Repression of p53-mediated transcription by MDM2: a dual mechanism". Genes Dev. 11 (15): 1974–86. doi:10.1101/gad.11.15.1974. PMC 316412. PMID 9271120. {{cite journal}}:  (עזרה)
↑  Bálint, E; Bates S; Vousden K H (ביולי 1999). "Mdm2 binds p73 alpha without targeting degradation". Oncogene. 18 (27): 3923–9. doi:10.1038/sj.onc.1202781. PMID 10435614. {{cite journal}}:  (עזרה)
↑  Zeng, X; Chen L, Jost C A; Maya R; Keller D; Wang X; Kaelin W G; Oren M; Chen J; Lu H (במאי 1999). "MDM2 suppresses p73 function without promoting p73 degradation". Mol. Cell. Biol. 19 (5): 3257–66. PMC 84120. PMID 10207051. {{cite journal}}:  (עזרה)
1 2  Mirnezami, Alexander H; Campbell Sandra J; Darley Matthew; Primrose John N; Johnson Peter W M; Blaydes Jeremy P (ביולי 2003). "Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription". Curr. Biol. 13 (14): 1234–9. doi:10.1016/S0960-9822(03)00454-8. PMID 12867035. {{cite journal}}:  (עזרה)
↑  Yogosawa, Satomi; Miyauchi Yasuhiro; Honda Reiko; Tanaka Hirofumi; Yasuda Hideyo (במרץ 2003). "Mammalian Numb is a target protein of Mdm2, ubiquitin ligase". Biochem. Biophys. Res. Commun. 302 (4): 869–72. doi:10.1016/S0006-291X(03)00282-1. PMID 12646252. {{cite journal}}:  (עזרה)
↑  Colaluca, Ivan N; Tosoni Daniela; Nuciforo Paolo; Senic-Matuglia Francesca; Galimberti Viviana; Viale Giuseppe; Pece Salvatore; Di Fiore Pier Paolo (בינואר 2008). "NUMB controls p53 tumour suppressor activity". Nature. 451 (7174): 76–80. doi:10.1038/nature06412. PMID 18172499. {{cite journal}}:  (עזרה)
↑  Haupt Y, Maya R, Kazaz A, Oren M (במאי 1997). "Mdm2 promotes the rapid degradation of p53". Nature. 387 (6630): 296–9. doi:10.1038/387296a0. PMID 9153395. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Honda, Tanaka & Yasuda 1997
↑  Zhang Y, Xiong Y, Yarbrough WG (במרץ 1998). "ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways". Cell. 92 (6): 725–34. doi:10.1016/S0092-8674(00)81401-4. PMID 9529249. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Clark, Paula A; Llanos Susana; Peters Gordon (ביולי 2002). "Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2". Oncogene. 21 (29): 4498–507. doi:10.1038/sj.onc.1205558. PMID 12085228. {{cite journal}}:  (עזרה)
↑  Pomerantz, J; Schreiber-Agus N; Liégeois N J; Silverman A; Alland L; Chin L; Potes J; Chen K; Orlow I; Lee H W; Cordon-Cardo C; DePinho R A (במרץ 1998). "The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53". Cell. 92 (6): 713–23. doi:10.1016/S0092-8674(00)81400-2. PMID 9529248. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Qiu W, Wu J, Walsh EM (ביולי 2008). "Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells". Oncogene. 27 (29): 4034–43. doi:10.1038/onc.2008.43. PMID 18332869. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Grossman SR, Perez M, Kung AL (באוקטובר 1998). "p300/MDM2 complexes participate in MDM2-mediated p53 degradation". Mol. Cell. 2 (4): 405–15. doi:10.1016/S1097-2765(00)80140-9. PMID 9809062. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Kadakia, Madhavi; Brown Thomas L; McGorry Molly M; Berberich Steven J (בדצמבר 2002). "MdmX inhibits Smad transactivation". Oncogene. 21 (57): 8776–85. doi:10.1038/sj.onc.1205993. PMID 12483531. {{cite journal}}:  (עזרה)
↑  Tanimura, S; Ohtsuka S; Mitsui K; Shirouzu K; Yoshimura A; Ohtsubo M (במרץ 1999). "MDM2 interacts with MDMX through their RING finger domains". FEBS Lett. 447 (1): 5–9. doi:10.1016/S0014-5793(99)00254-9. PMID 10218570. {{cite journal}}:  (עזרה)
↑  Badciong, James C; Haas Arthur L (בדצמבר 2002). "MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination". J. Biol. Chem. 277 (51): 49668–75. doi:10.1074/jbc.M208593200. PMID 12393902. {{cite journal}}:  (עזרה)
↑  Linke, K; Mace P D; Smith C A; Vaux D L; Silke J; Day C L (במאי 2008). "Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans". Cell Death Differ. 15 (5): 841–8. doi:10.1038/sj.cdd.4402309. PMID 18219319. {{cite journal}}:  (עזרה)
↑  Bernardi, Rosa; Scaglioni Pier Paolo; Bergmann Stephan; Horn Henning F; Vousden Karen H; Pandolfi Pier Paolo (ביולי 2004). "PML regulates p53 stability by sequestering Mdm2 to the nucleolus". Nat. Cell Biol. 6 (7): 665–72. doi:10.1038/ncb1147. PMID 15195100. {{cite journal}}:  (עזרה)
↑  Zhu, Hongyan; Wu Liqing; Maki Carl G (בדצמבר 2003). "MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53". J. Biol. Chem. 278 (49): 49286–92. doi:10.1074/jbc.M308302200. PMID 14507915. {{cite journal}}:  (עזרה)
↑  Kurki S, Latonen L, Laiho M (באוקטובר 2003). "Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization". J. Cell. Sci. 116 (Pt 19): 3917–25. doi:10.1242/jcs.00714. PMID 12915590. {{cite journal}}:  (עזרה)תחזוקה - ציטוט: multiple names: authors list (link)
↑  Wei, Xiaolong; Yu Zhong Kang; Ramalingam Arivudainambi; Grossman Steven R; Yu Jiang H; Bloch Donald B; Maki Carl G (באוגוסט 2003). "Physical and functional interactions between PML and MDM2". J. Biol. Chem. 278 (31): 29288–97. doi:10.1074/jbc.M212215200. PMID 12759344. {{cite journal}}:  (עזרה)
↑  Maguire, Maria; Nield Paul C; Devling Timothy; Jenkins Rosalind E; Park B Kevin; Polański Radoslaw; Vlatković Nikolina; Boyd Mark T (במאי 2008). "MDM2 regulates dihydrofolate reductase activity through monoubiquitination". Cancer Res. 68 (9): 3232–42. doi:10.1158/0008-5472.CAN-07-5271. PMID 18451149. {{cite journal}}:  (עזרה)
↑  Wang, Ping; Gao Hua; Ni Yanxiang; Wang Beibei; Wu Yalan; Ji Lili; Qin Linhua; Ma Lan; Pei Gang (בפברואר 2003). "Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2". J. Biol. Chem. 278 (8): 6363–70. doi:10.1074/jbc.M210350200. PMID 12488444. {{cite journal}}:  (עזרה)
1 2  Wang, Ping; Wu Yalan; Ge Xin; Ma Lan; Pei Gang (במרץ 2003). "Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus". J. Biol. Chem. 278 (13): 11648–53. doi:10.1074/jbc.M208109200. PMID 12538596. {{cite journal}}:  (עזרה)
1 2  Shenoy, Sudha K; Xiao Kunhong; Venkataramanan Vidya; Snyder Peter M; Freedman Neil J; Weissman Allan M (באוגוסט 2008). "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor". J. Biol. Chem. 283 (32): 22166–76. doi:10.1074/jbc.M709668200. PMC 2494938. PMID 18544533. {{cite journal}}:  (עזרה)
↑  Song, Min Sup; Song Su Jung; Kim So Yeon; Oh Hyun Jung; Lim Dae-Sik (ביולי 2008). "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex". EMBO J. 27 (13): 1863–74. doi:10.1038/emboj.2008.115. PMC 2486425. PMID 18566590. {{cite journal}}:  (עזרה)
↑  Yang, Wensheng; Dicker David T; Chen Jiandong; El-Deiry Wafik S (במרץ 2008). "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2". Cell Cycle. 7 (5): 670–82. doi:10.4161/cc.7.5.5701. PMID 18382127. {{cite journal}}:  (עזרה)
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