Mestarien liigan kauden 2007–2008 pudotuspelit
Neljännesvälierät > Ensimmäiset osaottelut

Neljännesvälierien ensimmäiset osaottelut pelattiin 19. ja 20. helmikuuta 2008.
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| 19. helmikuuta 2008 19.45 (UTC) |  FC Schalke 04 | 1–0 |  FC Porto |   |
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|   | Kevin Kurányi 4'  | (1–0) |   | Veltins-Arena, Saksa     Tuomari:  Laurent Duhamel |
|   | Kevin Kurányi 4'  |   |   | Veltins-Arena, Saksa     Tuomari:  Laurent Duhamel |
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| 19. helmikuuta 2008 19.45 (UTC) |  AS Roma | 2–1 |  Real Madrid |   |
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|   | David Pizarro 24'  Mancini 58'  | (1–1) | Raúl 8'  | Rooman olympiastadion     Tuomari:  Herbert Fandel |
|   | David Pizarro 24'  Mancini 58'  |   | Raúl 8'  | Rooman olympiastadion     Tuomari:  Herbert Fandel |
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| 19. helmikuuta 2008 19.45 (UTC) |  Olympiakos | 0–0 |  Chelsea FC |   |
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|   |   | (0–0) |   | Karaiskákis Stadium, Ateena     Tuomari:  Konrad Plautz |
|   |   |   |   | Karaiskákis Stadium, Ateena     Tuomari:  Konrad Plautz |
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| 19. helmikuuta 2008 19.45 (UTC) |  Liverpool FC | 2–0 |  FC Internazionale Milano |   |
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|   | Dirk Kuyt 85'  Steven Gerrard 90'  | (0–0) |   | Anfield, Liverpool     Tuomari:  Frank De Bleeckere |
|   | Dirk Kuyt 85'  Steven Gerrard 90'  |   |   | Anfield, Liverpool     Tuomari:  Frank De Bleeckere |
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| 20. helmikuuta 2008 19.45 (UTC) |  Celtic FC | 2–3 |  FC Barcelona |   |
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|   | Jan Vennegoor of Hesselink 16'  Robson 38'  | (2–1) | Lionel Messi 18', 79'  Thierry Henry 52'  | Celtic Park, Glasgow     Tuomari:  Peter Fröjdfeldt |
|   | Jan Vennegoor of Hesselink 16'  Robson 38'  |   | Lionel Messi 18', 79'  Thierry Henry 52'  | Celtic Park, Glasgow     Tuomari:  Peter Fröjdfeldt |
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| 20. helmikuuta 2008 19.45 (UTC) |  Olympique Lyonnais | 1–1 |  Manchester United |   |
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|   | Karim Benzema 54'  | (0–0) | Carlos Tévez 87'  | Stade Gerland, Lyon     Tuomari:  Luis Medina Cantalejo |
|   | Karim Benzema 54'  |   | Carlos Tévez 87'  | Stade Gerland, Lyon     Tuomari:  Luis Medina Cantalejo |
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| 20. helmikuuta 2008 19.45 (UTC) |  Fenerbahçe SK | 3–2 |  Sevilla FC |   |
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|   | Mateja Kežman 17'  Lugano 57'  Semih Şentürk 87'  | (1–1) | Edu Dracena 23'  om. Julien Escudé 66'  | Fenerbahçe Şükrü Saracoğlu, Istanbul     Tuomari:  Florian Meyer |
|   | Mateja Kežman 17'  Lugano 57'  Semih Şentürk 87'  |   | Edu Dracena 23'  om. Julien Escudé 66'  | Fenerbahçe Şükrü Saracoğlu, Istanbul     Tuomari:  Florian Meyer |
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| 20. helmikuuta 2008 19.45 (UTC) |  Arsenal FC | 0–0 |  AC Milan |   |
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|   |   | (0–0) |   | Arsenal Stadium, Lontoo     Tuomari:  Claus Bo Larsen |
|   |   |   |   | Arsenal Stadium, Lontoo     Tuomari:  Claus Bo Larsen |