Parhaan naispääosan Oscar-palkinto
Voittajat ja ehdokkaat > 2000-luku

| Vuosi | Näyttelijä | Elokuva | Rooli | Lähde |
| --- | --- | --- | --- | --- |
| 2000 | Julia Roberts ‡ | Erin Brockovich | Erin Brockovich |  |
| 2000 | Joan Allen | Kandidaatti | Laine Hanson |  |
| 2000 | Juliette Binoche | Pieni suklaapuoti | Vianne Rocher |  |
| 2000 | Ellen Burstyn | Unelmien sielunmessu | Sara Goldfarb |  |
| 2000 | Laura Linney | Väärät ystävät | Sammy Prescott |  |
| 2001 | Halle Berry ‡ | Monster’s Ball | Leticia Musgrove |  |
| 2001 | Judi Dench | Iris | Iris Murdoch |  |
| 2001 | Nicole Kidman | Moulin Rouge! | Satine |  |
| 2001 | Sissy Spacek | Satimessa | Ruth Fowler |  |
| 2001 | Renée Zellweger | Bridget Jones – elämäni sinkkuna | Bridget Jones |  |
| 2002 | Nicole Kidman ‡ | Tunnit | Virginia Woolf |  |
| 2002 | Salma Hayek | Frida | Frida Kahlo |  |
| 2002 | Diane Lane | Kohtalokas syrjähyppy | Constance ”Connie” Sumner |  |
| 2002 | Julianne Moore | Kaukana taivaasta | Cathy Whitaker |  |
| 2002 | Renée Zellweger | Chicago | Roxie Hart |  |
| 2003 | Charlize Theron ‡ | Monster – Aileen Wuornos | Aileen Wuornos |  |
| 2003 | Keisha Castle-Hughes | Valasratsastaja | Paikea Apirana |  |
| 2003 | Diane Keaton | Jotain annettavaa | Erika Berry |  |
| 2003 | Samantha Morton | In America | Sarah Sullivan |  |
| 2003 | Naomi Watts | 21 grammaa | Cristina ”Cris” Williams-Peck |  |
| 2004 | Hilary Swank ‡ | Million Dollar Baby | Margaret ”Maggie” Fitzgerald |  |
| 2004 | Annette Bening | Being Julia | Julia Lambert |  |
| 2004 | Catalina Sandino Moreno | Maria Full of Grace | María Álvarez |  |
| 2004 | Imelda Staunton | Vera Drake | Vera Rose Drake |  |
| 2004 | Kate Winslet | Tahraton mieli | Clementine Kruczynski |  |
| 2005 | Reese Witherspoon ‡ | Walk the Line | June Carter Cash |  |
| 2005 | Judi Dench | Mrs. Henderson esittää | Laura Henderson |  |
| 2005 | Felicity Huffman | Transamerica | Sabrina ”Bree” Osbourne / Stanley Schupak |  |
| 2005 | Keira Knightley | Ylpeys ja ennakkoluulo | Elizabeth Bennet |  |
| 2005 | Charlize Theron | North Country | Josey Aimes |  |
| 2006 | Helen Mirren ‡ | The Queen | Kuningatar Elisabet II |  |
| 2006 | Penélope Cruz | Volver – paluu | Raimunda |  |
| 2006 | Judi Dench | Paljastavat merkinnät | Barbara Covett |  |
| 2006 | Meryl Streep | Paholainen pukeutuu Pradaan | Miranda Priestly |  |
| 2006 | Kate Winslet | Little Children | Sarah Pierce |  |
| 2007 | Marion Cotillard ‡ | Pariisin varpunen – Edith Piaf | Édith Piaf |  |
| 2007 | Cate Blanchett | Elisabet – kultainen aikakausi | Kuningatar Elisabet I |  |
| 2007 | Julie Christie | Away from Her | Fiona Anderson |  |
| 2007 | Laura Linney | The Savages | Wendy Savage |  |
| 2007 | Ellen Page | Juno | Juno MacGuff |  |
| 2008 | Kate Winslet ‡ | Lukija | Hanna Schmitz |  |
| 2008 | Anne Hathaway | Rachel Getting Married | Kym Buchman |  |
| 2008 | Angelina Jolie | Changeling – vaihdokas | Christine Collins |  |
| 2008 | Melissa Leo | Frozen River | Ray Eddy |  |
| 2008 | Meryl Streep | Doubt – Epäilys | Aloysius Beauvier |  |
| 2009 | Sandra Bullock ‡ | Elämä pelissä | Leigh Anne Tuohy |  |
| 2009 | Helen Mirren | Viimeinen asema | Sophia Tolstoy |  |
| 2009 | Carey Mulligan | An Education | Jenny Mellor |  |
| 2009 | Gabourey Sidibe | Precious | Claireece ”Precious” Jones |  |
| 2009 | Meryl Streep | Julie & Julia | Julia Child |  |