Parhaan miespääosan Oscar-palkinto
Voittajat ja ehdokkaat > 2000-luku

| Vuosi | Näyttelijä | Elokuva | Rooli | Lähde |
| --- | --- | --- | --- | --- |
| 2000 | Russell Crowe ‡ | Gladiator | Maximus Decimus Meridius |  |
| 2000 | Javier Bardem | Ennen yötä | Reinaldo Arenas |  |
| 2000 | Tom Hanks | Cast Away – tuuliajolla | Chuck Noland |  |
| 2000 | Ed Harris | Pollock | Jackson Pollock |  |
| 2000 | Geoffrey Rush | Quills – syntiset säkeet | Markiisi de Sade |  |
| 2001 | Denzel Washington ‡ | Training Day | Det. Alonzo Harris |  |
| 2001 | Russell Crowe | Kaunis mieli | John Forbes Nash |  |
| 2001 | Sean Penn | Minä olen Sam | Sam Dawson |  |
| 2001 | Will Smith | Ali | Muhammad Ali |  |
| 2001 | Tom Wilkinson | Satimessa | Dr. Matt Fowler |  |
| 2002 | Adrien Brody ‡ | Pianisti | Władysław Szpilman |  |
| 2002 | Nicolas Cage | Adaptation. Minun versioni | Charlie Kaufman Donald Kaufman |  |
| 2002 | Michael Caine | Hiljainen amerikkalainen | Thomas Fowler |  |
| 2002 | Daniel Day-Lewis | Gangs of New York | William ”Bill the Butcher” Cutting |  |
| 2002 | Jack Nicholson | About Schmidt | Warren R. Schmidt |  |
| 2003 | Sean Penn ‡ | Menneisyyden ote | Jimmy Markum |  |
| 2003 | Johnny Depp | Pirates of the Caribbean: Mustan helmen kirous | Jack Sparrow |  |
| 2003 | Ben Kingsley | Hiekan ja sumun talo | Massoud Amir Behrani |  |
| 2003 | Jude Law | Päämääränä Cold Mountain | W. P. Inman |  |
| 2003 | Bill Murray | Lost in Translation | Bob Harris |  |
| 2004 | Jamie Foxx ‡ | Ray | Ray Charles |  |
| 2004 | Don Cheadle | Hotelli Ruanda | Paul Rusesabagina |  |
| 2004 | Johnny Depp | Finding Neverland – tarinan lähteillä | J. M. Barrie |  |
| 2004 | Leonardo DiCaprio | Lentäjä | Howard Hughes |  |
| 2004 | Clint Eastwood | Million Dollar Baby | Frankie Dunn |  |
| 2005 | Philip Seymour Hoffman ‡ | Capote | Truman Capote |  |
| 2005 | Terrence Howard | Hustle & Flow | Djay |  |
| 2005 | Heath Ledger | Brokeback Mountain | Ennis Del Mar |  |
| 2005 | Joaquin Phoenix | Walk the Line | Johnny Cash |  |
| 2005 | David Strathairn | Good Night, and Good Luck. | Edward R. Murrow |  |
| 2006 | Forest Whitaker ‡ | The Last King of Scotland | Idi Amin |  |
| 2006 | Leonardo DiCaprio | Blood Diamond – veritimantti | Danny Archer |  |
| 2006 | Ryan Gosling | Half Nelson | Dan Dunne |  |
| 2006 | Peter O’Toole | Venus | Maurice |  |
| 2006 | Will Smith | Onnen potkuja | Chris Gardner |  |
| 2007 | Daniel Day-Lewis ‡ | There Will Be Blood | Daniel Plainview |  |
| 2007 | George Clooney | Michael Clayton | Michael Clayton |  |
| 2007 | Johnny Depp | Sweeney Todd – Fleet Streetin paholaisparturi | Sweeney Todd/Benjamin Barker |  |
| 2007 | Tommy Lee Jones | In the Valley of Elah | Hank Deerfield |  |
| 2007 | Viggo Mortensen | Eastern Promises | Nikolai Luzhin |  |
| 2008 | Sean Penn ‡ | Milk | Harvey Milk |  |
| 2008 | Richard Jenkins | The Visitor | Walter Vale |  |
| 2008 | Frank Langella | Frost/Nixon | Richard Nixon |  |
| 2008 | Brad Pitt | Benjamin Buttonin uskomaton elämä | Benjamin Button |  |
| 2008 | Mickey Rourke | The Wrestler – painija | Randy ”The Ram” Robinson |  |
| 2009 | Jeff Bridges ‡ | Crazy Heart | Otis ”Bad” Blake |  |
| 2009 | George Clooney | Up in the Air | Ryan Bingham |  |
| 2009 | Colin Firth | A Single Man | George Falconer |  |
| 2009 | Morgan Freeman | Invictus – voittamaton | Nelson Mandela |  |
| 2009 | Jeremy Renner | The Hurt Locker | Vääpeli William James |  |