أشباه أفيونيات
علم العقاقير > ملامح ملزمة

الملامح الملزمة للمواد الأفيونية في المستقبلات الأفيونية (كي ، نانومتر)
| Compound | MOR | DOR | KOR | Ref |  |
| --- | --- | --- | --- | --- | --- |
| 7-هيدروكسي ميتراجينين | 13.5 | 155 | 123 |  |  |
| β-كلورنالتريكسامين | 0.90 | 115 | 0.083 |  |  |
| β-إندورفين | 1.0 | 1.0 | 52 |  |  |
| β- فونالتريكسامين | 0.33 | 48 | 2.8 |  |  |
| الازوسين | 2.7 | 4.1 | 3.2 |  |  |
| (-) - الازوسين | 3.0 | 15 | 4.7 |  |  |
| (+) - الازوسين | 1,900 | 19,000 | 1,600 |  |  |
| الفنتانيل | 39 | 21,200 | 7008999999999000000♠ND |  |  |
| بينالتورفيمين | 1.3 | 5.8 | 0.79 |  |  |
| BNTX | 18 | 0.66 | 55 |  |  |
| بريمازوسين | 0.75 | 2.3 | 0.089 |  |  |
|   (-) - بريمازوسين | 0.62 | 0.78 | 0.075 |  |  |
| البوبرينورفين | 4.18 | 25.8 | 12.9 |  |  |
| بوتورفانول | 1.7 | 13 | 7.4 |  |  |
| BW-3734 | 26 | 0.013 | 17 |  |  |
| كارفينتانيل | 0.024 | 3.3 | 43 |  |  |
| كودايين | 79 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 |  |  |
| CTOP | 0.18 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 |  |  |
| سيكلازوسين | 0.45 | 6.3 | 5.9 |  |  |
| سيبروديم | 9.4 | 356 | 176 |  |  |
| دادل | 16 | 0.74 | 7003100000000000000♠>1,000 |  |  |
| دامجو | 2.0 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 |  |  |
| [D-Ala2] دلتورفين الثاني | 7003100000000000000♠>1,000 | 3.3 | 7003100000000000000♠>1,000 |  |  |
| Dermorphin | 0.33 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 |  |  |
| (+)-Desmetramadol | 17 | 690 | 1,800 |  |  |
| Dextropropoxyphene | 34.5 | 380 | 1,220 |  |  |
| Dezocine | 3.6 | 290 | 460 |  |  |
| Dihydroetorphine | 0.45 | 1.82 | 0.57 |  |  |
| Diprenorphine | 0.072 | 0.23 | 0.017 |  |  |
| DPDPE | 7003100000000000000♠>1,000 | 14 | >1,000 |  |  |
| DSLET | 39 | 4.8 | 7003100000000000000♠>1,000 |  |  |
| Dynorphin A | 32 | 7003100000000000000♠>1,000 | 0.5 |  |  |
| Ethylketazocine | 3.1 | 101 | 0.40 |  |  |
|   (−)-Ethylketazocine | 2.3 | 5.2 | 2.2 |  |  |
|   (+)-Ethylketazocine | 2,500 | 7004100000000000000♠>10,000 | 1,600 |  |  |
| Etorphine | 0.23 | 1.4 | 0.13 |  |  |
| Fentanyl | 0.39 | 7003100000000000000♠>1,000 | 255 |  |  |
| Hydrocodone | 11.1 | 962 | 501 |  |  |
| Hydromorphone | 0.47 | 18.5 | 24.9 |  |  |
| ICI-204488 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 | 0.71 |  |  |
| Leu-enkephalin | 3.4 | 4.0 | >1,000 |  |  |
| Levacetylmethadol | 9.86 | 169 | 1,020 |  |  |
| Lofentanil | 0.68 | 5.5 | 5.9 |  |  |
| Met-enkephalin | 0.65 | 1.7 | >1,000 |  |  |
| Metazocine | 3.8 | 44.3 | 13.3 |  |  |
| Methadone | 1.7 | 435 | 405 |  |  |
|   Dextromethadone | 19.7 | 960 | 1,370 |  |  |
|   Levomethadone | 0.945 | 371 | 1,860 |  |  |
| Methallorphan | 7008999999999000000♠ND | 7008999999999000000♠ND | 7008999999999000000♠ND | ND |  |
|   Dextrallorphan | 1,140 | 2,660 | 34.6 |  |  |
|   Levallorphan | 0.213 | 2.18 | 1,100 |  |  |
| Methorphan | 7008999999999000000♠ND | 7008999999999000000♠ND | 7008999999999000000♠ND | ND |  |
|   Dextromethorphan | 1,280 | 11,500 | 7,000 |  |  |
|   Levomethorphan | 11.2 | 249 | 225 |  |  |
| Mitragynine | 7.24 | 60.3 | 1,100 |  |  |
| Mitragynine pseudoindoxyl | 0.087 | 3.02 | 79.4 |  |  |
| Morphanol | 7008999999999000000♠ND | 7008999999999000000♠ND | 7008999999999000000♠ND | 7008999999999000000♠ND |  |
|   Dextrorphan | 420 | 7004347000000000000♠34٬700 | 7003595000000000000♠5٬950 |  |  |
|   Levorphanol | 0.42 | 3.61 | 4.2 |  |  |
| Morphiceptin | 56 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 |  |  |
| Morphine | 1.8 | 90 | 317 |  |  |
|   Morphine, (−)- | 1.24 | 145 | 23.4 |  |  |
|   Morphine, (+)- | 7004100000000000000♠>10,000 | 7005100000000000000♠>100,000 | 7005300000000000000♠>300,000 |  |  |
| MR-2266 | 1.0 | 3.0 | 0.16 |  |  |
| Nalbuphine | 11 | 7003100000000000000♠>1,000 | 3.9 |  |  |
| Nalmefene | 0.24 | 16 | 0.083 |  |  |
| Nalorphine | 0.97 | 148 | 1.1 |  |  |
| Naloxonazine | 0.054 | 8.6 | 11 |  |  |
| Naloxone | 1.1 | 16 | 12 |  |  |
|   (−)-Naloxone | 0.93 | 17 | 2.3 |  |  |
|   (+)-Naloxone | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 |  |  |
| Naltrexone | 1.0 | 149 | 3.9 |  |  |
| Naltriben | 12 | 0.013 | 13 |  |  |
| Naltrindole | 64 | 0.02 | 66 |  |  |
| Norbinaltorphimine | 2.2 | 65 | 0.027 |  |  |
| Normorphine | 4.0 | 310 | 149 |  |  |
| Ohmefentanyl | 0.0079 | 10 | 32 |  |  |
| Oxycodone | 8.69 | 901 | 1,350 |  |  |
| Oxymorphindole | 111 | 0.7 | 228 |  |  |
| Oxymorphone | 0.78 | 50 | 137 |  |  |
| Pentazocine | 5.7 | 31 | 7.2 |  |  |
| Pethidine (meperidine) | 385 | 7003435000000000000♠4٬350 | 5,140 |  |  |
| Phenazocine | 0.20 | 5.0 | 2.0 |  |  |
| PLO17 | 30 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 |  |  |
| Quadazocine | 0.99 | 2.6 | 0.5 |  |  |
| Salvinorin A | 7004100000000000000♠>10,000 | 7004100000000000000♠>10,000 | 16 |  |  |
| Samidorphan | 0.052 | 2.6 | 0.23 |  |  |
| SIOM | 33 | 1.7 | >1,000 |  |  |
| Spiradoline | 21 | 7003100000000000000♠>1,000 | 0.036 |  |  |
| Sufentanil | 0.15 | 50 | 75 |  |  |
| Tianeptine | 383 | 7004100000000000000♠>10,000 | 7004100000000000000♠>10,000 |  |  |
| Tifluadom | 32 | 189 | 2.1 |  |  |
| Tramadol | 7003212000000000000♠2٬120 | 7004577000000000000♠57٬700 | 7004427000000000000♠42٬700 |  |  |
|   (+)-Tramadol | 7003133000000000000♠1٬330 | 7004624000000000000♠62٬400 | 7004540000000000000♠54٬000 |  |  |
|   (−)-Tramadol | 7004248000000000000♠24٬800 | 7005213000000000000♠213٬000 | 7004535000000000000♠53٬500 |  |  |
| U-50488 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 | 0.12 |  |  |
| U-69593 | 7003100000000000000♠>1,000 | 7003100000000000000♠>1,000 | 0.59 |  |  |
| Xorphanol | 0.25 | 1.0 | 0.4 |  |  |
القيم هي Ki (نانومتر)، ما لم يذكر خلاف ذلك. كلما كانت القيمة أصغر ، زادت قوة ارتباط الدواء بالموقع. تم إجراء الاختبارات في الغالب باستخدام مستقبلات القوارض المستنسخة أو المستزرعة.: القيم هي Ki (نانومتر)، ما لم يذكر خلاف ذلك. كلما كانت القيمة أصغر ، زادت قوة ارتباط الدواء بالموقع. تم إجراء الاختبارات في الغالب باستخدام مستقبلات القوارض المستنسخة أو المستزرعة.