HIF1A
مراجع

↑  Semenza GL، Rue EA، Iyer NV، Pang MG، Kearns WG (يونيو 1996). "Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q". Genomics. ج. 34 ع. 3: 437–9. DOI:10.1006/geno.1996.0311. PMID:8786149.
1 2  Hogenesch JB، Chan WK، Jackiw VH، Brown RC، Gu YZ، Pray-Grant M، Perdew GH، Bradfield CA (مارس 1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". The Journal of Biological Chemistry. ج. 272 ع. 13: 8581–93. DOI:10.1074/jbc.272.13.8581. PMID:9079689. S2CID:14908247.
↑  "Entrez Gene: HIF1A hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)". مؤرشف من الأصل في 2024-01-20.
↑  "The Nobel Prize in Physiology or Medicine 2019". NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 18 Jun 2024. مؤرشف من الأصل في 2019-10-08. {{استشهاد ويب}}: تحقق من التاريخ في: |تاريخ= (مساعدة)
↑  Wang GL، Jiang BH، Rue EA، Semenza GL (يونيو 1995). "Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension". Proceedings of the National Academy of Sciences of the United States of America. ج. 92 ع. 12: 5510–4. Bibcode:1995PNAS...92.5510W. DOI:10.1073/pnas.92.12.5510. PMC:41725. PMID:7539918.
↑  Iyer NV، Kotch LE، Agani F، Leung SW، Laughner E، Wenger RH، Gassmann M، Gearhart JD، Lawler AM، Yu AY، Semenza GL (يناير 1998). "Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha". Genes & Development. ج. 12 ع. 2: 149–62. DOI:10.1101/gad.12.2.149. PMC:316445. PMID:9436976.
↑  Hogenesch JB، Gu YZ، Jain S، Bradfield CA (مايو 1998). "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". Proceedings of the National Academy of Sciences of the United States of America. ج. 95 ع. 10: 5474–9. Bibcode:1998PNAS...95.5474H. DOI:10.1073/pnas.95.10.5474. PMC:20401. PMID:9576906.
↑  Woods SL، Whitelaw ML (مارس 2002). "Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ج. 277 ع. 12: 10236–43. DOI:10.1074/jbc.M110752200. PMID:11782478. S2CID:25125998.
↑  Ema M، Hirota K، Mimura J، Abe H، Yodoi J، Sogawa K، Poellinger L، Fujii-Kuriyama Y (أبريل 1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300". The EMBO Journal. ج. 18 ع. 7: 1905–14. DOI:10.1093/emboj/18.7.1905. PMC:1171276. PMID:10202154.
↑  Bhattacharya S، Michels CL، Leung MK، Arany ZP، Kung AL، Livingston DM (يناير 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. ج. 13 ع. 1: 64–75. DOI:10.1101/gad.13.1.64. PMC:316375. PMID:9887100.
1 2  Park YK، Ahn DR، Oh M، Lee T، Yang EG، Son M، Park H (يوليو 2008). "Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation". Molecular Pharmacology. ج. 74 ع. 1: 236–45. DOI:10.1124/mol.108.045278. PMID:18426857. S2CID:31675735.
↑  Lando D، Peet DJ، Whelan DA، Gorman JJ، Whitelaw ML (فبراير 2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. ج. 295 ع. 5556: 858–61. Bibcode:2002Sci...295..858L. DOI:10.1126/science.1068592. PMID:11823643. S2CID:24045310.
↑  Freedman SJ، Sun ZY، Poy F، Kung AL، Livingston DM، Wagner G، Eck MJ (أبريل 2002). "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha". Proceedings of the National Academy of Sciences of the United States of America. ج. 99 ع. 8: 5367–72. Bibcode:2002PNAS...99.5367F. DOI:10.1073/pnas.082117899. PMC:122775. PMID:11959990.
1 2  Mahon PC، Hirota K، Semenza GL (أكتوبر 2001). "FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity". Genes & Development. ج. 15 ع. 20: 2675–86. DOI:10.1101/gad.924501. PMC:312814. PMID:11641274.
1 2  Chen D، Li M، Luo J، Gu W (أبريل 2003). "Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function". The Journal of Biological Chemistry. ج. 278 ع. 16: 13595–8. DOI:10.1074/jbc.C200694200. PMID:12606552. S2CID:85351036.
1 2  Ravi R، Mookerjee B، Bhujwalla ZM، Sutter CH، Artemov D، Zeng Q، Dillehay LE، Madan A، Semenza GL، Bedi A (يناير 2000). "Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha". Genes & Development. ج. 14 ع. 1: 34–44. DOI:10.1101/gad.14.1.34. PMC:316350. PMID:10640274.
1 2  Kim BY، Kim H، Cho EJ، Youn HD (فبراير 2008). "Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation". Experimental & Molecular Medicine. ج. 40 ع. 1: 71–83. DOI:10.3858/emm.2008.40.1.71. PMC:2679322. PMID:18305400.
↑  Hansson LO، Friedler A، Freund S، Rudiger S، Fersht AR (أغسطس 2002). "Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53". Proceedings of the National Academy of Sciences of the United States of America. ج. 99 ع. 16: 10305–9. Bibcode:2002PNAS...9910305H. DOI:10.1073/pnas.122347199. PMC:124909. PMID:12124396.
↑  An WG، Kanekal M، Simon MC، Maltepe E، Blagosklonny MV، Neckers LM (مارس 1998). "Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha". Nature. ج. 392 ع. 6674: 405–8. Bibcode:1998Natur.392..405A. DOI:10.1038/32925. PMID:9537326. S2CID:4423081.
↑  Cho S، Choi YJ، Kim JM، Jeong ST، Kim JH، Kim SH، Ryu SE (يونيو 2001). "Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7". FEBS Letters. ج. 498 ع. 1: 62–6. DOI:10.1016/S0014-5793(01)02499-1. PMID:11389899. S2CID:83756271.
1 2  Jung JE، Kim HS، Lee CS، Shin YJ، Kim YN، Kang GH، Kim TY، Juhnn YS، Kim SJ، Park JW، Ye SK، Chung MH (أكتوبر 2008). "STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination". Experimental & Molecular Medicine. ج. 40 ع. 5: 479–85. DOI:10.3858/emm.2008.40.5.479. PMC:2679355. PMID:18985005.
↑  Haase VH (2009). "The VHL tumor suppressor: master regulator of HIF". Current Pharmaceutical Design. ج. 15 ع. 33: 3895–903. DOI:10.2174/138161209789649394. PMC:3622710. PMID:19671042.
↑  André H، Pereira TS (أكتوبر 2008). "Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha". The Journal of Biological Chemistry. ج. 283 ع. 43: 29375–84. DOI:10.1074/jbc.M805919200. PMC:2662024. PMID:18694926.
↑  Corn PG، McDonald ER، Herman JG، El-Deiry WS (نوفمبر 2003). "Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein". Nature Genetics. ج. 35 ع. 3: 229–37. DOI:10.1038/ng1254. PMID:14556007. S2CID:22798700.
↑  Li Z، Wang D، Na X، Schoen SR، Messing EM، Wu G (أبريل 2003). "The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity". The EMBO Journal. ج. 22 ع. 8: 1857–67. DOI:10.1093/emboj/cdg173. PMC:154465. PMID:12682018.
↑  Tanimoto K، Makino Y، Pereira T، Poellinger L (أغسطس 2000). "Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein". The EMBO Journal. ج. 19 ع. 16: 4298–309. DOI:10.1093/emboj/19.16.4298. PMC:302039. PMID:10944113.
↑  Min JH، Yang H، Ivan M، Gertler F، Kaelin WG، Pavletich NP (يونيو 2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science. ج. 296 ع. 5574: 1886–9. Bibcode:2002Sci...296.1886M. DOI:10.1126/science.1073440. PMID:12004076. S2CID:19641938.
↑  Yu F، White SB، Zhao Q، Lee FS (أغسطس 2001). "HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation". Proceedings of the National Academy of Sciences of the United States of America. ج. 98 ع. 17: 9630–5. Bibcode:2001PNAS...98.9630Y. DOI:10.1073/pnas.181341498. PMC:55503. PMID:11504942.
↑  Sun YY، Wang CY، Hsu MF، Juan SH، Chang CY، Chou CM، Yang LY، Hung KS، Xu J، Lee YH، Hsu CY (يوليو 2010). "Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1alpha in a cell-type-specific manner". The Journal of Neuroscience. ج. 30 ع. 28: 9621–30. DOI:10.1523/JNEUROSCI.2295-10.2010. PMC:6632428. PMID:20631191.
↑  Menshanov PN، Bannova AV، Dygalo NN (يناير 2017). "Anoxia ameliorates the dexamethasone-induced neurobehavioral alterations in the neonatal male rat pups". Hormones and Behavior. ج. 87: 122–128. DOI:10.1016/j.yhbeh.2016.11.013. PMID:27865789. S2CID:4108143.