      Next

        'Add all the Channels to the Channels ComboBox;
        ChannelsBox.Items.AddRange(allchannels.ToArray)

        'The Channels are now ready to be used, Tell the user to Select a Channel;
        ChannelsBox.Text = "Select a Channel..."

    Catch ex As Exception

        'Channel Data couldn't be loaded;
        ErrorImage.Width = "640"
        ErrorImage.Height = "391"
        ErrorImage.Visible = True

    End Try

End Sub

A:

Your code needs to be significantly reworked.  First, youSaudi Arabia has rejected a draft agreement with the government of Indonesia on the employment of domestic workers.

Some members of the kingdom’s advisory body, the Shoura Council, said the agreement did not go far enough to protect the rights of the employer, the state news agency said.

Another council member said the provisions in the agreement reflected negatively on the image of working in the kingdom.

There are about 9 million expatriate workers in Saudi Arabia, including thousands of domestic workers such as maids and drivers.

Indonesia and Saudi Arabia have had a tense relationship in regards to the hiring of Indonesian workers.

The former Indonesian government suspended migration of its citizens to the Arab state in August, 2011, on the grounds they were being exploited.

It was lifted in early 2013 after


Cerebellar Granule Cells: Dense, Rich and Evolving Representations.
For half a century it was assumed that granule cells use ultra-sparse encoding, but now in vivo calcium-imaging studies have shown that large ensembles of granule cells provide dense signals, which themselves evolve and adapt during training.1. Field of the Invention
The present invention relates to motor vehicles and in particular to a reinforcement system for a body frame rail.
2. Description of Related Art
Reinforcing systems have been previously proposed. A rear suspension connecting structure can be used under a floor of a motor vehicle. Vertical reinforcements and vertical bulkheads have been used in attempts to reinforce a structure including a cross member and a side member. Gillespie et al. (U.S. Pat. No. 7,393,015) teaches a vehicle sub-frame attachment apparatus and method. Gillespie teaches a mounting pin that is welded at the bottom to a sub-frame mounting bracket. Gillespie also teaches a shear planar bulk head that includes a channel for receiving the pin. The pin is welded to the shear planar bulk head. In addition,


further tolerate such behavior." (Young v. Rosenthal (1989) 212 Cal. App.3d 96, 119 [260 Cal. Rptr. 369], cert. den. ___ U.S. ___ [108 L.Ed.2d 941, 110 S.Ct. 1811].)
Waicis argues, however, that Dr. Frankel complied in good faith with the discovery order for the Saturday deposition by staying as long as possible and longer than the two hours noticed. This argument ignores the trial court's factual determination that Dr. Frankel was to be available all day Saturday. The argument is also premised on the dubious assumption a deponent has the right to unilaterally terminate a deposition at his convenience, and also ignores the fact the trial court imposed the sanction not just for Dr. Frankel leaving the deposition before it was completed, but for the pattern of the doctor'sCo. v. Hefley, 158 U.S. 98, 104; Southern Railway Co. v. Reid, 222 U.S. 424; Northern Pacific Railway Co. v. Washington, 222 U.S. 370.
We come next to consider whether rights arising under the congressional act may be enforced, as of right, in the courts of the States when their jurisdiction, as prescribed by local laws, is adequate to the occasion. The first of the cases now before us was begun in one of the Superior Courts of the State of Connecticut, and, in that case, the Supreme Court of Errors of the State answered the question in the negative. That, however, was not because the ordinary jurisdiction of the Superior Courts, as defined by the constitution and laws of the State, was deemed inadequate or not adapted to


and arising under the Constitution or laws of the United States." August 13, 1888, 25 Stat. 433, c. 866, § 1. Robb v. Connolly, 111 U.S. 624, 637; United States v. Barnes, 222 U.S. 513. This is emphasized by the amendment engrafted upon the original act in 1910, to the effect that "The jurisdiction of the courts of the United States under this Act shall be concurrent with that of the courts of the several States, and no case arising under this Act and brought in any state court of competent jurisdiction shall be removed to any court of the United States." The amendment, as appears by its language, instead of granting jurisdiction to the state courts, presupposes that they already possessed it.
Because of some general observations inepisode so far, and obviously there’s a lot of mystery surrounding him. No spoilers of course, but can you give us one reason that the fans should root for Lucas?

Chris:Well, I think he has charm.

TP: He certainly is charming, I won’t deny that.

Chris: He also, it may not seem like it, but he puts others before himself.

TP: Interesting. I like that.

TP: Were you given Lucas’ whole story up front when you took the job or did you learn about him like the viewers will one week at a time?

Chris: A little bit of both. I had a couple of key points discussed with me right before we started shooting the season. And then some of those I found came up in the scripts and some didn’t.

So, I had


Vectorworks Fundamentals 2019, student2PRO Version

Fundamentals Student2PRO is only for students graduated within the past year (proof of graduation).Must be purchased by the student and license will be registered in his/her name.

Student2PRO Academic Requirements

A graduate who purchases Vectorworks software through the student2PRO program must sign a Policy Agreement form that outlines the special guidelines and terms of this software purchase. The graduate is also required to provide school-supplied proof of graduation, which lists course study/degree and graduation date. The below requirements are outlined in the Policy Agreement:

Graduate of a designed-based curriculum or program at a post-secondary school within the past 12 months.

Official school-supplied proof of graduation including graduation date.

Only one Vectorworks professional license may be purchased through student2PRO.

All sales through student2PRO are final; licenses purchased through this program cannotonly for students graduated within the past year (proof of graduation).Must be purchased by the student and license will be registered in his/her name.ENN-P1-NEW-VRXZ-BE11280+1 (415) 848 9018

Vectorworks Fundamentals 2019 — student2PRO Version will be be digitally delivered to you. Within 1 or 2 working days from your purchase you will receive an e-mail with your Licensing Information and instructions on how to download and activate the software.

Vectorworks Fundamentals 2019 — student2PRO Version will be delivered digitally, no Sales Tax will be collected by Novedge.


month Australia have started their first clinical trial for the treatment of cerebral palsy. This is a phase 1 trial of matched sibling cord blood at the Royal Children’s Hospital in Melbourne with funding from the Cerebral Palsy Alliance and Cell Care, Australia’s largest family cord blood bank.

They also have several sports medicine trials on the go at Lakeside Sports Medicine Centre for the treatment of osteo-arthritis using stem cells. Cell and animal data, as well as early human studies have shown cartilage regeneration as well as improvement in pain and function. These trials are extremely important as osteo-arthritis is such a common condition with a huge cost to the economy . There are also several other interesting animal and human trials in lung diseases of prematurity, stroke,cranial reconstruction, graft vs host disease, auto-immune diseases and liver disease.

China is a leader in the field of clinical research, particularly with mesenchymal stem cells (MSC’s). The large majority of umbilical cord tissue trials are based in the Far East. They also presented some very promising data on the use of MSC’s co-transplanted with haematopoietic stem cells (HSC’s) showing better engraftment of transplants (and ultimately success) and a reduced incidence of graft vs host disease (transplant rejection). They offer a variety of banking services including cord blood, cord tissue, placental tissues, adipose (fat) tissues and even dental stem cell banking. They have several clinical MSC products on the market for a variety of conditions ranging from MSC gels for wound healing to injectable products.

Europe also has several trials


\usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$ \mathrm{Recall}=\frac{\mathrm{True}\ \mathrm{positives}}{\mathrm{True}\ \mathrm{positives}+\mathrm{False}\ \mathrm{negatives}} $$\end{document}$$

We also reported an overall measure of model performance, the area under the receiver operator characteristic curve (AUROC) \[[@CR25]\].

Results {#Sec17}
=======

Fifty-eight participants were recruited to the study between August 2017 and January 2018. Of these, eight participants did not meet the inclusion criteria and were excluded from analysis (Fig. [2](#Fig2){ref-type="fig"}). Fig. 2Study enrolment flow diagram

The primary diagnosis was unclear in two cases. One case was classified histologically as 'peri-appendicitis' with normal mucosa, and the other as inflammatory bowel disease. In both cases, there was evidence of inflammation at the appendix, but the casesfactor XI:Ag was 0.34 +/- 0.05 U/mL. In all, 13 kindreds had between 1 and 11 members with bleeding; the other 12 had none with deficient hemostasis. Two heterozygous factor XI-deficient individuals appeared to be positive for cross-reacting material (CRM+). The slope of the regression line for factor XI:C and factor XI:Ag data points in the 78 individuals tested did not differ from control, and all points fell within 95% confidence limits derived from control. In conclusion, bleeding tendency appears to be consistent within a given kindred and is not determined exclusively by factor XI:C or factor XI:Ag levels.


Field of the Invention. The present invention relates to methods and apparatus for modifying tissue in a patient.
Many pathological conditions in the human body may be caused by enlargement, movement, displacement and/or a variety of other changes of bodily tissue, causing the tissue to press against (or “impinge on”) one or more otherwise normal tissues or organs. For example, a cancerous tumor may press against an adjacent organ and adversely affect the functioning and/or the health of that organ. In other cases, bony growths (or “bone spurs”), arthritic changes in bone and/or soft tissue, redundant soft tissue, or other hypertrophic bone or soft tissue conditions may impinge on nearby nerve and/or vascular tissues and compromise functioning of one or more nerves, reduce blood flow through a blood vessel,correction pending) aboard the ship has
   been destroyed. G'Kar seems extremely distraught.

   [INLINE] G'Kar chants a prayer.

   A meeting has been called concerning the accident in the bay. Neeoma
   Connally, a labor leader on B5, and Ambassador G'Kar attend the
   meeting with the usual B5 command staff. Connally is quite adamant in
   her belief that the laborers should not be blamed for the accident.
   When Sinclair suggests that the computer malfunction in the bay could
   have been caused by human error, Connally disagrees--but she claims
   that even if the accident *were* caused by human error, nothing else
   could be expected from an


 think this is funny, huh? Well, I don't."

   "We're as serious as a rip in a spacesuit," replies Connally, "and we
   want the Senate and Commander Sinclair to know it."

   "By staging an illegal strike?" asks Garibaldi. "I thought you were
   smarter than that."

   "Sinclair and Ivanova are career military," replies Connally. "I don't
   expect them to understand. But I figure you for blue collar under all
   that Earthforce grey."

   Garibaldi explains that he understands their dilemma, but he feels
   that they're handling the problem incorrectly. He explains to her that
   Sinclair wants to speakZento closes the channel, the communicator beeps again. This
   time, G'Kar is on the channel--he says that he must meet with Sinclair
   to discuss a very important matter. Sinclair agrees, but only after
   G'Kar notes that he "wouldn't want to burden" Sinclair further by
   raising this matter before an entire assembly of the council.

   Sinclair arrives at the council chambers to meet with G'Kar. "Are you
   telling me this is about a flower?" asks Sinclair after G'Kar explains
   the situation.

   "Not just a flower, commander. The very symbol of my faith," replies
   G'Kar. He explains that all followers of G'Quan must perform a ritual


me to
   end this strike. I'm authorized to use any means necessary." After
   confirming this fact with Zento, and after Sinclair is assured that he
   has Zento's full support, Sinclair explains what "necessary means"
   he's going to use to stop the strike: First, Sinclair will reallocate
   1.3 million credits from B5's military budget in order to begin
   necessary upgrades of docking equipment and to start hiring more
   workers. Second, Sinclair will declare a complete amnesty for dock
   workers who have struck but who have committed no other crime. Zento
   angrily protests, but Sinclair comments that it was Zento who allowed
   Sinclair to use these means by convincing thewhen the computer replies that there is
   one transmission holding, Sinclair tells the computer to send the
   message through. The message is from Hidoshi, who tells Sinclair that
   he admires what Sinclair has done on B5 concerning the labor
   situation--however, the Senate doesn't. In this instance, however, the
   Senate has allowed Sinclair's decision to stand without
   comment--because public opinion is on Sinclair's side. Hidoshi tells
   Sinclair that he sympathizes with his decision--and is glad to see the
   discomfort it has caused some of his colleagues (for Hidoshi's
   grandfather was a dock worker himself). He is calling just to warn
   Sinclair that Zento has powerful friends, and that by


Q:

Deprecated: Function eregi() is deprecated in C:\wamp\

please when using the eregi() function to validate an email address i got this error:
Deprecated: Function eregi() is deprecated in C:\wamp\www\ssiphone\classes\TraitementFormulaireContact.php on line 13

my code which may make problem is :
 public function verifierMail($mail)
 {
    if(eregi("^[_a-z0-9-]+(\.[_a-z0-9-]+)*@[a-z0-9-]+(\.[a-z0-9-]+)*(\.[a-z]{2,3})$", $mail)) {
      return "valid mail";
    }
    else {
      return "invalid mail";
    }
}

A:

the eregi function is deprecated, which means that in future versions of PHP it will be removed.
You can replace it with the function preg_match which does pretty much the same thing.
Sample code (untested):
public function verifierMail($mail)
{
if(preg_match("/^[_a-z0-9-]+(\.[_a-z0-9-]+)*@[a-z0-9-]+(\.[a-z0-9-]+)*(\.[a-z]{2,3})$/i", $mail)) {
  return "valid mail";
}
else {
  echo "invalid mail";
}

The /i makes it case insensitive

       CORE::$ObjSiS['SIS']['MEMORYUSAGE']['LASTRUN']= NULL; #Guarda la memoria Numerica de la ultima ejecucion
        CORE::$ObjSiS['SIS']['MEMORYUSAGE']['RUNNING']= NULL; #Guardara la memoria Numerica usada por el sistema al final de cada ejecucion.
        CORE::$ObjSiS['SIS']['MEMORYUSAGE']['RUNNINGTXT'] = NULL; #Guardara la memoria Textual usada por el sistema al final de cada ejecucion.
        CORE::$ObjSiS['SIS']['HTTPR']['HTTPM']= NULL; #Guardara el Metodo en el que se esta recibiendo una peticion HTTP_REQUEST si existe GET O POST
        CORE::$ObjSiS['SIS']['HTTPR']['HTTPST']   = false; #Guardara si se Recibio alguna peticion HTTP_REQUEST false predeterminado, true
        CORE::$ObjSiS['SIS']['HTTPR']['PROTOCOL'] = NULL; #Guardara el Metodo en el que se esta


 CORE::$ObjSiS['DISPLAY']['SUCCESSFUL']['MODAL2'] = NULL; #Establecemos la variable que almacenara si una ejecucion fue correcta por Modal 2
        CORE::$ObjSiS['DISPLAY']['ERROR']= NULL; #Establecemos la Variable que Almacenara si una ejecucion termino en error por pantalla
        CORE::$ObjSiS['DISPLAY']['ERROR']['MODAL1']  = NULL; #Establecemos la Variable que Almacenara si una ejecucion termino en error por Modal 1
        CORE::$ObjSiS['DISPLAY']['ERROR']['MODAL2']  = NULL; #Establecemos la Variable que Almacenara si una ejecucion termino en error por Modal 2
        CORE::$ObjSiS['DISPLAY']['ALERT']= NULL; #Establecemos la Variable que Almacenara si una ejecucion termino con alguna alerta por pantalla
        CORE::$ObjSiS['DISPLAY']['ALERT']['MODAL1']  = NULL; #Establecemos la Variable que Almacenarafor several applications in the field of nanomagnetism^[@ref19],[@ref20]^ such as magnetic nanoprobes^[@ref21]^ and nano-Hall-^[@ref22]^ and magnetologic devices.^[@ref8],[@ref23]^ For example, Franken et al. recently demonstrated how OP-nanopillars (NP) can be used as pinning sites for magnetic domain wall.^[@ref24]^

In this work, we demonstrate the first ever deposition of combined Fe-based IP-NW and OP-NP arrays for 3D-NML computing. In addition, a novel way of imaging the magnetic properties of such arrays has been developed. Magnetic force microscopy (MFM) imaging of nanostructures with very high aspect ratios is not feasible with commercially available probes due to the significant topographic artifacts, caused by the shape of the tip. Therefore, conventional pyramidal AFM tips have been modified by FEBID in order to obtain high-aspect-ratio, tilt-compensated MFM probes. The FEBID-modified probes developed here helped minimizing


Despite objections from liberals and progressives, the Center for American Progress (CAP) hosted Benjamin Netanyahu on Tuesday afternoon, giving him a platform to spout wild fabrications and half-truths to a left-leaning audience completely unchallenged.

As Politico aptly put it, the Israeli prime minister “stepped into a liberal lions’ den on Tuesday — and walked away with nary a scratch.”

The event was billed as a “moderated conversation” between Netanyahu and the influential Democratic-leaning think tank’s president Neera Tanden. But far more monologue than dialogue, it felt like an hour-long one-man show starring an Israeli leader who seemed to be on a mission to determine how many lies he could tell without challenge.

It was a remarkable spectacle mostly because Netanyahu is a hardline right-winger whose ideological counterparts in the US includerepression technology is often sold to abusive and tyrannical governments.

But Tanden didn’t challenge him on that either. Instead she let him ramble on about his so-called “start-up nation,” prompting Netanyahu to issue one of the only truthful statements of the hour.

“I wanted to get my commercial in so you could understand how great an investment Israel is,” he remarked.


the season with a win Sunday at home.The Lions, after back-to-back 9-7 seasons under Jim Caldwell, are 5-10 under first-year coach Matt Patricia. They enter Sunday with seven losses in their last nine games, failing to surpass 20 points in eight of those games.”I think it’s a great week for us to go out and compete and get better,” Patricia told the media this week. “Obviously, with a game against such a storied program like the Green Bay Packers, with such rich history and tradition and the division and all the rest of it, there’s no place you’d rather be in the circumstances that we have. We’ve got to go up to Lambeau and play a very good team against a great staff, against great players, great quarterback.digital data packet from the command station and puts it out on your railroad layout using your track wiring to the rails. A DCC equipped Locomotive has a decoder ... Track Wiring Wiring for DCC by Allan Gartner RECOMMENDATION: Build a Short Detecting Beeper BEFORE You Start ANY DCC Track Wiring! It's no accident that this recommendation is the first in the track wiring section. If you wait until you find out you have shorts, it's too late. Don't wait until you wish you had made one of these. Do it now. DCC Basics The DCC Shop About The DCC Shop DCC Basics Contact Us   Guide to ...    Left hand schematic is of a typical bedroom or shelf home layout DCC wiring diagram.


Read: Is Joe Biden running for president? He can’t decide.

Biden pulled the plug at the last minute in 2015, and some of those closest to him warn he still may this time.

Biden has said as much himself.

In January, he went to the New York offices of BlackRock, the major investment firm, for a meeting with Larry Fink, the CEO. They talked about the state of the world and the country, about what’s going on in the markets. Toward the end, Fink said to Biden, “I’m here to help,” according to people told about the conversation.

Biden took it as an offer to sign on with the campaign.

“I’m 70 percent there, but I’m not all the way there,” Biden told Fink.

That same 70 percent line has been circulating among Bidenallies for weeks: This looks like it’s happening, but don’t write off the 30 percent chance that it doesn’t. In that time, people who’ve spoken with Biden and those around him say he is still anguishing over both whether there’s a path to victory and whether running is the right thing to do for those closest to him, knowing that his record would be attacked and sensitive questions about his family would be aired in public.

Read: Why Joseph Crowley’s defeat should scare Joe Biden

“His heart is saying, ‘Go. It’s the thing you’ve always wanted,’” said one person who’s been in touch with Biden’s staff. “His head is assessing whether there’s an opening.”

Trump worries and offends Biden, and he feels a sense of duty to the government and the


areas, indicating that in these regions at least one variable exceeded the training range. Predictions in these areas represent extrapolation and need to be interpreted with caution. The colonization, establishment and dispersion in potentially suitable areas involve a number of environmental and intrinsic factors of the species, many of which are not yet fully clarified \[[@pone.0183143.ref085]\]. On a local scale, factors such as environmental alterations, biotic interactions and the ability of dispersion may prevent the establishment of these species in climatically suitable areas \[[@pone.0183143.ref006],[@pone.0183143.ref008]\]. Consequently, possible differences between realized and potential distributions can be observed. In addition, it is important to stress that some regions were suggested by the models as inadequate (areas of potential absence) which does not necessarily mean that the species can be deliberately introducedPedro \[[@pone.0183143.ref050]\], *P*. *guttatus* has the highest percentage (43.37%) of pet advertisements sold illegally on the Internet in southeastern Brazil, with the largest amount of vendors detected between 2006 and 2012. Consequently, the risk of escape or release of propagules in these environments is greater, which requires the attention of the responsible agencies, especially regarding the monitoring of these areas.

### Lampropeltis Triangulum {#sec013}

Appropriate areas for this species include mainly the biomes of the Atlantic forest, Cerrado and Pampa, and include various sustainable use conservation and full protection units, for instance, the Integral Protection Area (APA) of Ibirapuitã, one of two national protected areas of Pampa \[[@pone.0183143.ref101]\]; the APA of Islands and Valleys of the Paraná River, one of the largest of the Atlantic forest; and the APA of


* @fn:		Pointer to the function that will be called for each request
 *		associated with @hctx that has been assigned a driver tag.
 *		@fn will be called as follows: @fn(@hctx, rq, @data, @reserved)
 *		where rq is a pointer to a request. Return true to continue
 *		iterating tags, false to stop.
 * @data:	Will be passed as third argument to @fn.
 * @reserved:	Indicates whether @bt is the breserved_tags member or the
 *		bitmap_tags member of struct blk_mq_tags.
 */
static void bt_for_each(struct blk_mq_hw_ctx *hctx, struct sbitmap_queue *bt,
			busy_iter_fn *fn, void *data, bool reserved)
{
	struct bt_iter_data iter_data = {
		.hctx = hctx,
		.fn = fn,
		.data = data,
		.reserved = reserved,
	};

	sbitmap_for_each_set(&bt->sb, bt_iter, &iter_data);
}

struct bt_tags_iter_data {
	struct blk_mq_tags *tags;
	busy_tag_iter_fn *fn;
	void *data;
	unsigned int flags;
};

#define BT_TAG_ITER_RESERVED		(1 << 0)
#define BT_TAG_ITER_STARTED		(1 << 1)
#define BT_TAG_ITER_STATIC_RQS		(1 << 2)

static bool bt_tags_iter(struct sbitmap *bitmap, unsigned int bitnr, void *data)
{
	struct bt_tags_iter_data *iter_datahardware queue associated with the request. 'reserved'
 *		indicates whether or not @rq is a reserved request.
 * @priv:	Will be passed as third argument to @fn.
 *
 * Note: if @q->tag_set is shared with other request queues then @fn will be
 * called for all requests on all queues that share that tag set and not only
 * for requests associated with @q.
 */
void blk_mq_queue_tag_busy_iter(struct request_queue *q, busy_iter_fn *fn,
		void *priv)
{
	struct blk_mq_hw_ctx *hctx;
	int i;

	/*
	 * __blk_mq_update_nr_hw_queues() updates nr_hw_queues and queue_hw_ctx
	 * while the queue is frozen. So we can use q_usage_counter to avoid
	 * racing with it. __blk_mq_update_nr_hw_queues() uses
	 * synchronize_rcu() to ensure this function left the critical section
	 * below.
	 */
	if (!percpu_ref_tryget(&q->q_usage_counter))
		return;

	queue_for_each_hw_ctx(q, hctx, i) {
		struct blk_mq_tags *tags = hctx->tags;

		/*
		 * If no software queues are currently mapped to this


on a circulating orbit for applying a high frequency electromagnetic field to a charged particle beam circulating and for increasing amplitude of betatron oscillation of the particle beam to a level above a stability limit of resonance. Additionally, for beam ejection, four-pole divergence electromagnets are arranged: (1) downstream with respect to a first deflector; (2) upstream with respect to a deflecting electromagnet; (3) downstream with respect to the deflecting electromagnet; and (4) and upstream with respect to a second deflector.
K. Hiramoto, et. al. “Circular Accelerator and Method and Apparatus for Extracting Charged-Particle Beam in Circular Accelerator”, U.S. Pat. No. 5,363,008 (Nov. 8, 1994) describe a circular accelerator for extracting a charged-particle beam that is arranged to: (1) increase displacement of a beam by the effect of betatron oscillationthe efficacy of supplemental DHA combined with neoadjuvant chemotherapy in treatment-naïve women with breast cancer measured by changes in Ki67 index from biopsy to surgical excision. We hypothesise that DHA supplementation will increase plasma phospholipid DHA and improve response to neoadjuvant chemotherapy assessed by a decrease in the Ki67 index.

This protocol follows the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline (SPIRIT checklist: [online supplementary table 1](#SP1){ref-type="supplementary-material"}; WHO checklist: [online supplementary table 2](#SP2){ref-type="supplementary-material"}).[@R29]

10.1136/bmjopen-2019-030502.supp1

10.1136/bmjopen-2019-030502.supp2

Study design {#s1-2}
------------

The Docosahexaenoic acid (DHA) for [W]{.ul}omen with Breast Cancer in the Neoadjuvant Setting (DHA WIN) trial will be a two-arm, double-blind, phase II, randomised controlled trial comparing DHA supplementation and placebo (vegetable oil). The proposed study design with outcomes depicted is shown in [figure 1](#F1){ref-type="fig"}, and the SPIRIT participant flow chart is shown


size, we will also assess differences in DHA incorporation in patients with different breast cancer subtypes and if subtype or disease stage affects DHA incorporation into plasma, controlling for the reported dose taken by the patient. The goal is to determine if plasma phospholipid DHA content can be used to predict treatment outcomes. We will also assess incorporation of other essential fatty acids (linoleic, linolenic, arachidonic, eicosapentaenoic, docosapentaenoic) to determine if there are differences between or within treatment groups.

-   Systemic immune function: Systemic immune function will be assessed on blood samples obtained at baseline, beginning of chemotherapy cycle 4 (day 1±3 days) and at the end of chemotherapy treatment. Changes in markers of systemic immune cell type and function will be assessed following supplementation compared withtreatment groups.

-   Exercise behaviour: Exercise behaviour will be determined by questionnaire employed at baseline, each cycle of chemotherapy and end of treatment. Comparisons will be assessed from end of treatment to baseline within and between treatment groups.

-   Breast conservation: The rate of breast conservation, specifically the rate of lumpectomy and mastectomy, will be determined by review of surgical and pathological reports at the end of study after surgical resection.

-   Volume of surgical blood loss: High intakes of n-3 LCPUFA (that contain some DHA) have been studied to determine if they increase bleeding time.[@R39] We will review surgical report estimates of blood loss to see if there is a qualitative or quantitative difference between placebo and treatment arms, once adjusted for the magnitude


coefficient of variation \<5%, and individual gas chromotography (GC) peaks are validated against phospholipid standards (GLC-502 and GLC-643) from NuChek (Elysian, Minnesota).

Phenotyping of immune cell subsets will be measured using whole blood (collected in EDTA tubes). The various cell types will be identified using specific fluorescently labelled monoclonal antibodies to surface receptors (see [online supplementary table 4](#SP5){ref-type="supplementary-material"} for list of antibodies). These will be quantified by flow cytometry, as previously described.[@R46] With the remaining blood, peripheral mononuclear cells will be isolated and purified on a Ficoll density gradient of Histopaque-1077 as previously described.[@R46] To measure cytokine production in isolated lymphocytes, cells will be cultured in media with or without the mitogens, phytohemagglutinin or lipopolysaccharide, for 48 hours as previously described.[@R48] Supernatant will be collected and stored at −80°CAmusement park train rides for sale, popular kiddie rides in the amusement park. Amusement park trains become more and more ...Read More

Railroad train sets for backyard are privately owned by people who has a backyard, backyard trains usually comes in small sizes for one or several persons or kids to ride on. A large backyard need more equipment to decorate. Train sets is the best one!

Kiddie train rides, also called track and trackless train rides, some of them are popular used in the amusement parks, but some of them are popular use for private or we can say backyard. These trains are made according to the real trains. It is made up of one locomotive and several coaches. Most of the coaches are made with cartoon features, for


of public mental health supervisors in general in that all have received EBT training are positive about TF-CBT as an intervention and the enterprise of implementing EBT in public mental health.

Conclusions
===========

The proposed study has significance for both implementation science and public health, as the ultimate goal of improving supervision in community-based mental health settings is to increase quality of care and clinical outcomes for children and adolescents through improving clinician fidelity. The timing of the current investigation is particularly opportune, given the current momentum and support for the use of EBTs, as well as increasing attention to accountable care. However, the potential public health impact of wide-scale provision of EBTs cannot be realized when EBTs are not sustained post-initial efforts. Increasingly, federal and state-funded EBT implementation efforts arewho have been acting in a fascistic manner.

Cheok had announced on Twitter on Nov. 23 that Bannon would instead be the keynote speaker for a new conference. The former White House advisor will talk about the future of populism at the “Inaugural Athenian Parrhesia Free-Speech Forum” at the University of Montana on Dec. 11. This event has, however, been postponed until further notice.

LSR controversies

In the past, the LSR workshop has faced challenges such as being banned from Malaysia and having to make a last-minute venue change in London due to threats.

According to the event’s website, the International Congress on Love and Sex with Robots “provides an excellent opportunity for academics and industry professionals to present and discuss their innovative work and ideas in an academic symposium.”


            final StandardServer server = (StandardServer) event.getSource();

                TomcatHelper.setServer(server);

                final Properties properties = new Properties();
                System.getProperties().setProperty("openejb.embedder.source", getClass().getSimpleName());
                properties.setProperty("openejb.embedder.source", getClass().getSimpleName());

                // if SystemInstance is already initialized, then return
                if         final Properties tomcatServerInfo = IO.readProperties(classLoader.getResourceAsStream("org/apache/catalina/util/ServerInfo.properties"), new Properties());

                    String serverNumber = tomcatServerInfo.getProperty("server.number");
                    if (serverNumber == null) {
                        // Tomcat5 only has server.info
                        final String serverInfo = tomcatServerInfo.getProperty("server.info");


Syrian Hackers Fail

Hackers sympathizing with the embattled government of Syrian president Bashar al-Assad attempted but failed to carry out what might have been a significant attack against the Web hosting company Wix.com in recent weeks.
http://goo.gl/aYTXdQ
#techsucceed, said Martalis. "Everywhere, you can hear people saying that they will not support a vote for a deal," he said. "They say it's crazy what they want to do to us, so I will vote no. Most of the people understand that, but also at the same time, they are afraid of what will happen."

THE REFERENDUM comes more than five months after SYRIZA took office pledging to halt austerity measures, revive the Greek economy and begin to restore social benefits that were radically cut back under governments that agreed to austerity measures encapsulated in the so-called Memorandums in exchange for financial bailouts from European authorities and the IMF.

Despite these promises, leaders of the new government offered substantial concessions--only to be faced with demands for even more austerity.

This


more austerity.

That debate has now come to a head. After winning a convincing victory in the January 25 elections, Tsiprsas and his economic team, led by Finance Minister Yanis Varoufakis, had proceeded on the assumption that the European institutions would bow to the new political reality in Greece and back off demands for even deeper austerity.

In his effort to make a deal, Tsipras signaled a willingness to retreat even before the election, setting aside SYRIZA's radical economic platform from its founding conference and putting forward the much milder Thessaloniki Program, named for a speech last fall given in that city.

Then came a major concession to the "institutions" on February 20--Tsipras essentially agreed to an extension of previous austerity and privatization programs, shelving even the milder planks in SYRIZA'sdetermined to drive Greece out of the eurozone. As Matt O'Brien of the Washington Post put it, European officials are "leaking stories about how shaky Greece's financial system is--not so much shouting "run" in a crowded bank as starting one--to put more pressure on the government to agree to a deal and agree to it now."

The stakes in Greece--and for the left internationally--are enormous. A "no" vote would not only be a message of resistance to Germany's economic empire in the EU, a call to action for anti-austerity activists, unions and working people across Europe and beyond.

As Tsipras put it in his speech announcing the referendum: "To authoritarianism and harsh austerity, we will respond with democracy, calmly and decisively." The people of Greece deserve solidarity and support as


4>( expr), context) , proto::eval(proto::child_c< 5>( expr), context) , proto::eval(proto::child_c< 6>( expr), context) , proto::eval(proto::child_c< 7>( expr), context));
        }
    };
    template<typename Expr, typename Context>
    struct default_eval<Expr, Context, proto::tag::function, 9>
    {
        typedef
            typename proto::detail::result_of_fixup<
                typename proto::result_of::eval< typename remove_reference< typename proto::result_of::child_c< Expr, 0>::type >::type , Context >::type
            >::type
        function_type;
        typedef
   illustrating the relative positional relationship among picture elements p of CCD chip 1, the sampling carrier c having a frequency of 3f.sub.sc and the sampling point s. It can be observed that at N line and at N+1 line, the position of the sampling point or the sampling timing s is changed so that at N+1 line the picture of each element will not be picked up.
In the case of sampling the information of the picture elements with phases of sampling pulses which are coincidence between the N and N+1 lines using the resetting operation discussed above as shown in FIG. 2C, when the sampling phase at, for example, N line coincides with the phase of the modulating color vector shown by the solid line in FIG. 1B,


Guide to Playing Online Blackjack

If you really want to enjoy playing online blackjack games, you have to know and understand all its strategies. The secret of successful Blackjack players is in the strategies they use and always continue to learn new ones. You can find various charts for blackjack on the internet and use them when you already start playing online.

The main benefit of online blackjack is that it has low house edge but at the same time offers higher payout percentage.

Before you start betting with real money be sure that you are familiar with the rules and you understand that you are already enough skilled to start playing. You can start of playing on free sites or you can use the demo versions of real casino sites.Let t(g) = 7*g - 7. Let y(o) = -6*o + 6. Determine z*t(p) - 6*y(p).
p - 1
Let n(l) = 10*l**2 + 6. Let b = 44 - 34. Suppose -2 = 8*w - b. Let d(s) = s**2 + 1. What is w*n(c) - 6*d(c)?
4*c**2
Let h(x) = 146*x**2 + 1. Let u(b) = -147*b**2 - 1. What is -3*h(c) - 4*u(c)?
150*c**2 + 1
Let i(t) = 12*t + 36. Let l(r) = -7*r - 19. Calculate 4*i(y) + 7*l(y).
-y + 11
Let t(j) = -j - 7. Let s(a) = -a - 11. Let g = 24 - 19. Suppose 5*b = 5*y + 60, b + 2 = -y - 2. Determine g*s(v) + y*t(v).
3*v + 1
Let z(b) = 48*b. Let k(a) be the third derivative of a**4/2


= -129*v**2 - 15*v - 11. Let b(q) = -44*q**2 - 6*q - 4. Calculate 8*b(z) - 3*n(z).
35*z**2 - 3*z + 1
Let w(h) = h + 5. Let l be w(-3). Let i(r) = r + 4. Let o(z) = -5*z + 9. Let p(y) = 2*y - 5. Let x(a) = 4*o(a) + 9*p(a). What is l*x(s) + 5*i(s)?
s + 2
Let h(m) = -8*m - 6. Let b(z) = -3*z. Give -4*b(a) + h(a).
4*a - 6
Let p(u) = u - 1. Suppose 4 + 6 = -5*l. Let b = l + 1. Let v(w) = -4*w + 4. Calculate b*v(c) - 6*p(c).
-2*c + 2
Let o(d) = 8*d**2 + 5*d + 1. Let i = 50 - 51. Let y be o(i). Let u(q) = -3*q -Lifetime Physical Fitness and Wellness: A Personalized Program

CERTAIN CONTENT THAT APPEARS ON THIS SITE COMES FROM AMAZON SERVICES LLC. THIS CONTENT IS PROVIDED 'AS IS' AND IS SUBJECT TO CHANGE OR REMOVAL AT ANY TIME.

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LIFETIME PHYSICAL CONDITIONINGS AND HEALTHS can help you take control of your personal physical fitness and health by providing current, useful info and tools to make positive choices for your health. The authors encourage you to examine your current habits in order to use the useful steps you discover in the text to start positive behavior changes. The text's unique design incorporates activities throughout each chapter to relate the content to your very own life and offers dynamic visuals and detailed examples to assist you envision crucial principles. Utilize the robust, online resources


Development, manufacture and characterization of niosomes for the delivery for nevirapine.
Nevirapine (NVP), used for the treatment of HIV/AIDS, exhibits unpredictable oral bioavailability, has a poor side effect profile and requires frequent dosing. Niosomes are novel drug delivery systems that have the potential to overcome these challenges. A thin layer hydration approach was used to produce niosomes and optimisation was undertaken using design of experiments (DoE) and response surface methodology (RSM) establish and identify parameters that may affect the manufacture of niosomes. The impact of cholesterol and surfactant content, hydration time and temperature on manufacture was investigated. Critical quality attributes (CQA) in respect of particle size (PS), entrapment efficiency (EE), polydispersity index (PDI) and the amount of NVP released at 48 hours was also assessed. The optimised niosome compositionprovide direct access. Instead, it provides ramps to parallel arterial roads; The East Mall and The West Mall run parallel with the freeway from Evans Avenue to Rathburn Road. A full interchange is provided shortly after with Burnhamthorpe Road, southwest of Burnhamthorpe Collegiate Institute. Across from the school, an off-ramp provides access from the southbound lanes to Holiday Drive and The West Mall. Following the off-ramp, to the north, is a partial interchange with Rathburn Road, which provides access from the northbound lanes and to the southbound lanes.

Transfers provide a second and final opportunity to cross between the express and collector lanes, or vice versa, south of the complicated  Highway 401 interchange. A final set of ramps along the collector-express system provides access to and from the southbound


QEW, the latter of which would become one of the worst bottlenecks in the province a decade after its completion, according to Minister of Transportation Charles MacNaughton.
By September 1956, it was possible to bypass Toronto entirely on the four lane divided highway composed of Highway 401 and Highway 27.
Highway 401 was extended to the west soon after,
but Highway 27 remained a two-lane highway north of it.

Airport Expressway (1964-1971)

During the early 1960s, Toronto International Airport was expanded with the construction of the Aeroquay One terminal.
To serve the expected demand of the expansion, the DHO built a new four-lane freeway north from Highway 401 at Renforth Drive. This new route, which roughly followed the same route as today's Highway 427 as far as Dixon/Airport Road, was known as the Toronto Airport Expressway and wasPrevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritis.
To evaluate the prevalence and pattern of arterial calcification in patients with rheumatoid arthritis (RA). Patients with RA are prone to premature atherosclerosis; nonetheless the prevalence and extent of atherosclerosis in different vascular beds and their relationship to each other remain unknown. We studied the distribution and extent of arterial calcification in 85 RA patients and 85 age-and sex-matched controls. Arterial calcification as determined by calcium score (CS) were measured using multi-detector computed tomography in thoracic aorta, coronary and carotid arteries. Compared with controls, RA patients had a significantly higher average CS and prevalence of CS > 0 in aorta, coronary and carotid arteries and overall arteries (all P < 0.05). After adjusting


for age and sex, RA patients had a significantly higher relative risk of developing calcification in the aorta [Odds Ratio (OR) = 19.5, 95% Confidence Interval (CI): 8.0-47.6], followed by the carotid arteries (OR = 5.7, 95% CI:1.7-18.7) and coronary arteries (OR = 5.0, 95% CI:2.2-11.1) compared with controls (all P < 0.01). Amongst RA patients aged >60, 90% had diffuse arterial calcification, especially over the thoracic aorta, compared with 55% of controls who had arterial calcification clustered in the coronary arteries (P < 0.05). RA patients with total CS > 0 were older with a higher urea level and C-reactive protein than those without arterial calcification, no factor was found to be independently predictive for arterial calcification (all P > 0.05). Our results demonstrated that RA patientsIt has previously been proposed--see the referenced U.S. Pat. No. 4,064,482, assigned to the assignee of the present application, the disclosure of which is hereby incorporated by reference, to provide inductive transducers located adjacent the wheels of the vehicle, which pick up signals from the tires of the vehicle representative of individual tire pressure, and to transmit the signals, via a wave-shaping circuit, to a shift register. The system is so arranged that the shift register which receives the signals from a transducer of one vehicle wheel is reset by signals received from a transducer of another vehicle wheel, for example at the side opposite to the first, so that the pulse train derived from the respective transducers of oppositely located wheels are compared. If a limiting value


field of view (FoV), 256 × 146 acquisition matrix, 100 × 1.8 mm slices, the T2W sequence had a propeller acquisition with TR/TE = 6000/90 ms, 24 × 24 cm FoV, 384 × 384 acquisition matrix, 28 × 5 mm slices, 1 mm slice gap, and the FLAIR had TR/TE/TI = 9000/153/2200 ms, 24 × 24 cm FoV, 384 × 224 acquisition matrix, 28 × 5 mm slices, 1 mm slice gap. Both year-of-birth cohort (normal ageing) studies had the same MRI acquisition protocol: T1W had TR/TE/TI = 9.7/3.984/500 ms, 25.6 × 25.6 cm^2^ FoV, 192 × 192 acquisition matrix, voxel size 1 × 1 × 1.3 mm^3^, T2W had TR/TE = 11320/102 ms, 25.6 × 25.6 FoV, 256 × 256 acquisition matrix, 80 × 2 mm slices, no inter-slice gap; and FLAIR had TR/TE/TI = 9000/140/2200 ms, 256 × 192 acquisition matrix, and 40 × 4 mm slices. All acquisitions were zero-filled and resampled to either 256 × 256 or 512 × 512 in-plane resolution matrices.

2.3. Image processing {#sec0045}
---------------------

The segmentation of the brain tissues and structures was performed following the protocol described in ([@bib0245],[@bib0250]). Briefly, binary masksproposed by ([@bib0090]) to describe local heterogeneity information in images. This method quantifies the relationship between grey levels in an image by counting the pairs of pixels separated by a predefined distance (d) and direction (θ) that have the same distribution of grey-level values. Each pixel of the resulting matrix represents the number of times that the grey level of a reference pixel and the grey level of the neighbour pixel in the predefined distance d and direction θ are seen in the image. Consequently, the size of the GLCM will be Ng × Ng, being Ng the number of grey levels of the image. Several statistics representing the homogeneity or heterogeneity of the image can be mathematically computed from the GLCM.

In our study, images were uniformly quantised to Ng = 32


the texture combinations that provided the highest AUC values were analysed again using the same cross validation structure with a feature selection step included within the model-building process to avoid overfitting ([@bib0010]). This way, we could test if reducing the number of features improved the classification results. Two filter feature selection methods were applied to obtain rankings of features based on the discriminative power of each feature independently without analysing the relation between features and without involving any predictive model ([@bib0120]). The first method used the *p*-value provided by the Mann-Whitney *U* test for independent groups of samples. The second method used the Maximal Information Coefficient (MIC), which measures the strength of the linear or non-linear association between two variables.

The model evaluation process was implemented with the Caretiterations when examining all the texture datasets with the two models under analysis (SVM with linear kernel and RF), and for all the MRI sequences and brain tissues/structures. A relevant AUC value could not be obtained (AUC \< 0.7) in any case. The best result was obtained using the GLCM parameters in the T2W images of the NAWM region using SVM with linear kernel (AUC = 0.667 ± 0.117), but this value was not accurate enough to determine that a good classification can be achieved using these data.Table 3Results of the classification analysis for cortical and lacunar stroke patients. The AUC values computed by averaging the results of the validation data (mean ± standard deviation) are shown for the two models (SVM with linear kernel and RF) and for all the MRI sequences and brain tissues/structures


values obtained when reducing the number of features according to the computed rankings in the best texture datasets. In general, better AUC values were obtained when reducing the number of features. In particular, it is remarkable the substantial improvement achieved for LBP parameters extracted from T2W images of the subcortical structures when using the SVM model: a final value of AUC = 0.828 ± 0.075 was obtained when only using the 7 more relevant LBP characteristics according to the MIC coefficient. [Fig. 5](#fig0025){ref-type="fig"} shows the AUC values obtained for all possible subsets of features according to the MIC ranking and the ROC curves provided by the model when using all the features and when using the optimal number of features.Table 6Values of AUC obtained when analysing the best texture datasets with anda large amount of quantitative texture descriptors. The number of patients per group was sufficiently large to draw reliable conclusions and the machine learning pipeline was designed to avoid overoptimistic and overfitted results. We achieved promising results that suggested that texture features may help in the detection of previous stroke lesions, and identified the textural features that look promising on this task, so as they can be evaluated in transfer learning schemes with the-state-of-the-art deep CNNs. Additionally, the correlation of our results with clinical parameters was explored to find clinical patterns or characteristics that could be reflected in the textural features that resulted promising to the classification tasks evaluated.

Conflicts of interest {#sec0140}
=====================

All authors declare no Conflict of Interests to report.

Study funding {#sec0145}
=============

This work was funded by the Row


Fogo Charitable Trust (MVH, VGC) grant no. BRO-D.FID3668413, and the Wellcome Trust (patient recruitment, scanning, primary study Ref No. 088134/Z/09). The study was conducted independently of the funders who do not hold the data and did not participate in the study design or analyses.

The Lothian Birth Cohort 1936 is funded by Age UK (Disconnected Mind grant) and the Medical Research Council (MRC; MR/M01311/1, G1001245, 82800), and the latter supported BSA. IJD was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology, which is funded by the MRC and the Biotechnology and Biological Sciences Research Council (MR/K026992/1).

David Moratal acknowledges financial support from the Spanish Ministerio de Economía y Competitividad (MINECO) and FEDER funds under Grant BFU2015-64380-C2-2-R, and from the Conselleria d\'Educació, Investigació, Cultura i Esport, Generalitat Valenciana (grantsAEST/2017/013 and AEST/2018/021).

Rafael Ortiz-Ramón was supported by grant ACIF/2015/078 and grant BEFPI/2017/004 from the Conselleria d'Educació, Investigació, Cultura i Esport of the Valencian Community (Spain).

We thank participants in the studies that provided data for this study, the radiographers and staff at the Brain Research Imaging Centre Edinburgh (<http://www.bric.ed.ac.uk/>), a SINAPSE (Scottish Imaging Network A Platform for Scientific Excellence, [www.sinapse.ac.uk/](http://www.sinapse.ac.uk/){#intr0040}) collaboration centre. We especially thank the following members of the research teams, who contributed to the recruitment, data collection or image processing in the primary studies, but did not participate in the analysis or writing of this report: Dr. Susana Muñoz Maniega, Dr. Natalie Royle, Mrs. Eleni Sakka, Miss. Catherine Murray, Miss Kirsten Shuler.

[^1]: Joint first authors.

[^2]: AUC: area under the curve, RF: random forest classifier, SVM: support vector


machine classifier, GLRM: grey--level run length matrix features, GLCM: grey-level co-occurrence matrix features, LBP: local binary patterns features, WCF: wavelet co-occurrence features, WSF: wavelet statistical features, NAWM: normal-appearing white matter, SS: subcortical structures, WMH: white matter hyperintensities.

[^3]: ^\*^Values in bold indicate the best AUC results (AUC \> 0.7).

[^4]: AUC: area under the curve, RF: random forest classifier, SVM: support vector machine classifier, GLRM: grey--level run length matrix features, GLCM: grey-level co-occurrence matrix features, LBP: local binary patterns features, WCF: wavelet co-occurrence features, WSF: wavelet statistical features, NAWM: normal-appearing white matter, SS: subcortical structures, WMH: white matter hyperintensities.

[^5]: AUC: area under the curve, RF: random forest classifier, SVM: support vector machine classifier, GLRM: grey--level run length matrix features, GLCM: grey-level co-occurrence matrix features, LBP: local binary patterns features, WCF: wavelet co-occurrencein tense exchanges with Democrats on the committee. At one point he asked Sen. Amy Klobuchar Amy KlobucharSocial media platforms put muscle into National Voter Registration Day Battle lines drawn on precedent in Supreme Court fight Sunday shows - Ruth Bader Ginsburg's death dominates MORE (D-Minn.) if she had ever blacked out from drinking after she asked him the same question.

The nominee’s conduct during the hearing caught the attention of many on the left, who cited his temperament as another reason to vote “no” on his confirmation. Klobuchar later said that if she “was in his courtroom and acted like that, he would have thrown me out.”

The FBI returned results of a nearly weeklong investigation into the allegations to the Senate on Thursday.

Senate Republicans claim that there was


Kuy in a coma.

Call to Action: For Kuy

Campaign: For Kuy

A campaign of solidarity, denouncing the attack our compañero was subjected to, demanding justice for him and for all of those injured on that date, and to demand unconditional freedom for all of those detained in Mexico City and in Guadalajara during the protests against the imposition of Enrique Peña Nieto as head of the federal executive branch.

According to each of your methods, time, means, and spaces, join us with local, national, and international activities on Sunday, February 17, 2013, as part of the Political-Cultural Day of Action for Kuy. In Mexico City we will join the cultural-artistic act in front of the Palacio de Bellas Artes, beginning at noon.

Ongoing fundraising campaign, to be deposited in the following bankserver, for example:
//from answer
var request1 = WebRequest.Create("ftp://myftpserver");

//from answer
var request2 = FileWebRequest.Create("ftp://myftpserver") as FileWebRequest;

var request3 = WebRequest.Create("ftp://myftpserver") as FtpWebRequest;

request1, request3 will have request value with type SystemNet.FtpWebRequest. request2 will be null.
The similar behavior will be when you try to use http://mywebserver: request2, request3 will be null.
when you use WebRequest the type of the request will be automatically detected by transfer protocol
So you don't need to think about whether file stored on web server/file server/ftp server


1. Introduction {#sec1-ijerph-17-01358}
===============

Workplace bullying is a peculiar form of interpersonal conflict in the workplace \[[@B1-ijerph-17-01358]\] defined as the systematic and persistent/repetitive experience of negative behavior at work, such as being withheld information that affects performance, being a target of rumors, or being socially isolated \[[@B2-ijerph-17-01358]\]. Workplace bullying has very negative consequences for the target's mental health and for the work organization as well \[[@B3-ijerph-17-01358],[@B4-ijerph-17-01358],[@B5-ijerph-17-01358]\].

Research on the antecedents of bullying has revealed two main types of potential cause. First, bullying can be triggered by poor working conditions \[[@B6-ijerph-17-01358],[@B7-ijerph-17-01358]\]. Research has shown, in fact, that work stressors such as role conflict, workload, and lack of social support are related to bullying, even prospectively \[[@B8-ijerph-17-01358],[@B9-ijerph-17-01358],[@B10-ijerph-17-01358]\]. Various processes have been proposed to explain the relationship between such stressors and the experience ofdemonstrated that the healthcare sector is characterized by highly stressful working conditions such as time pressure \[[@B22-ijerph-17-01358]\], long working hours \[[@B23-ijerph-17-01358]\], and motional demands \[[@B24-ijerph-17-01358]\]. Such distressing working conditions may be an advantage to study a strain-related phenomenon such as workplace bullying.

2. Materials and Methods {#sec2-ijerph-17-01358}
========================

2.1. Procedure and Participants {#sec2dot1-ijerph-17-01358}
-------------------------------

We conducted a two-wave study among health-sector employees working for a National Health Service (NHS) agency in Italy. We selected a one-year time lag in line with findings in occupational health research that have indicated a one-year lag as appropriate for demonstrating causal relationships between stressors and strain \[[@B25-ijerph-17-01358]\]. The data were collected using a paper-and-pencil self-report questionnaire administered during working hours on a voluntary basis. No ethical approval was sought as the study was part of a mandatory


analysis to test the study hypotheses. The path analytic model first fit to the data (M1) acted as the baseline model for testing Hypothesis 1 and Hypothesis 3 that, respectively, T1 job demand and T1 impaired mental health would impact T2 bullying. In this model, all the main study variables at T2 (i.e., bullying, job demand, job control, and impaired mental health) were predicted by their respective T1 level. Additionally, this model also included the correlations between the four variables at both T1 and T2, as well as a path from T1 bullying to T2 impaired mental health. The latter path accounted for a well-established influence of bullying on symptoms of impaired mental health. This model fit the data well (χ^2^ (11) = 16.77, *p* = 0.11; CFIgraphically represented in [Figure 1](#ijerph-17-01358-f001){ref-type="fig"}, the path from T1 job demand to T2 bullying was positive and significant (std. path = 0.12, *t* = 2.218, *p* \< 0.05), while the path from T1 impaired mental health to T2 bullying was not significant (std. path = 0.04, *t* = 0.787, ns). These results supported Hypothesis 1, while they did not support Hypothesis 3.

To check for the potential effect from T1 bullying to T2 job demand (i.e., reverse causation), we tested a further model (M3). M3 included the T1 bullying-T2 job demand path in addition to the paths included in M1. Results showed that M3 did not fit better than M1 (∆χ^2^ (1) = 2.127, ns) and that the path from T1 bullying to T2 job demand was not significant


the experience of bullying. Previous research on personal factors in bullying has either been descriptive in nature \[[@B39-ijerph-17-01358]\] or has investigated the potential main effect of such factors (e.g., \[[@B40-ijerph-17-01358]\]. Furthermore, almost all research has been cross-sectional in nature, with the consequence that the true causal direction of the postulated relationship is unclear.

Our results suggest that high job demand is a cause of bullying particularly for employees who report more symptoms of impaired mental health. The results are in line with the idea that individuals with impaired mental health have fewer personal resources (e.g., energy, self-control, assertiveness, and other coping skills) to deal with the tension generated by a high job demand. This, in turn, may lead them to experience more difficulties in regulating their behavior and emotionalpreparation, C.B.; writing---review and editing, C.B., E.B., S.T., F.F., A.V.d.B. All authors have read and agreed to the published version of the manuscript.

The publication of this article was funded by the personal research funding made available to the first (C.B.) and fourth (S.T.) authors by the University of Bologna.

The authors declare that there is no conflict of interest regarding the publication of this paper. The data used to support the findings of this study are available from the corresponding author upon request.

![Path analytic model testing the impact of T1 job demand and T1 impaired mental health on T2 bullying. Note. \* *p* \< 0.05. \*\* *p* \< 0.01. \*\*\* *p* \< 0.001.](ijerph-17-01358-g001){#ijerph-17-01358-f001}

![Path analytic model testing the interaction between T1 job demand and T1 impaired mental health (T1 JD


commuting charges is $N/2$. A convenient set of mutually commuting charges is $Q_{12},Q_{34},...$, which we label by Q\_ =Q\_[2-1,2]{} = j\_\^0. \[eq:1.5\]

The conservation of charges is implemented in the usual way by introducing Lagrange multipliers $\mu_{\alpha}$ and defining the generalized Hamiltonian density $\bar{{\cal H}}$ by $$\bar{{\cal H}}={\cal H}-\mu_{\alpha} J_{\alpha}^0,\label{eq:1.6}$$ where ${\cal H}$ is the usual Hamiltonian density. Here and in the following, greek indices are always summed from $1$ to $N/2$.

The canonical momenta which follow from (\[eq:1.2\]) are $$\Pi_a=\dot{\Phi}_a,
                   \label{eq:1.7}$$ and we have $${\cal
H}=\frac 1 2 \Pi_a\Pi_a+\frac 1 2 |\nabla\Phi|^2+
                    the one-loop contribution, eq. (\[210\]), exactly. However, we are interested in the Bose-Einstein condensation and the relevant range for this phenomenon is the high-temperature regime to which we will once more concentrate.

By the mentioned analogy with the free field, one may obtain without any calculation the high-temperature expansion in terms of quantities given through the zeta-function of the excitation energies, \_()=\_j (E\_[,j]{}\^2)\^[-]{},\[31\] or the associated heat-kernel coefficients, K\_(t)=\_j e\^[-E\_[,j]{}\^2 t]{}\~(1 [4t]{})\^[3 2]{} \_[l=0,1/2,...]{}\^b\_l\^t\^l.\[32\] By introducing $E_{\pm ,zeropoint}$, $\Omega_{\pm}$, as the quantities in (\[211\]) and (\[212\]) resulting from the excitation energies $E_{\pm, j}$, the results read \_ &=&-1 [2]{}PP\_(-1 2 )+1 [(4)\^2]{}\[33\]\
& &{-b\^\_2 ()+(2)+ b\_[3 2]{}\^+P\_+S\_},with S\_=-\_[r=1/2,1,...]{}\^b\_[2 +r]{}\^()\^[2r]{}\_R (1+2r)\[34\] and P\_=-\_[r=0,1/2,1]{}b\^\_r(2)\^ [-4+2r]{} (2 -r)\_R(4-2r).\[35\] Here, $PP\zeta_{\pm}(-1/2)$ denotes the finite part of $\zeta_{\pm}(s)$ at $s=-1/2$.

Thus we have reduced the task of


 x})\rbrace$ be a complete set of eigenfunctions of $-\nabla^2+\xi R$ with eigenvalues $\sigma_N$ : $$(-\nabla^2+\xi R)f_N({\bf x})=\sigma_Nf_N({\bf x})\;.
\label{eq:4.14}$$ We can write $$\begin{aligned}
          \Psi(t,{\bf  x})&=&\sum_N A_Ne^{-iE_Nt}f_N({\bf
x}),\label{eq:4.15}\\
          \Psi^\dagger(t,{\bf     x})&=&
\sum_NB_Ne^{-iE_Nt}f_N({\bf     x}),
          \label{eq:4.16}\end{aligned}$$ for some independent expansion coefficients $A_N$ and $B_N$. Substitution of (\[eq:4.15\],\[eq:4.16\]) into (\[eq:4.13\]) and its complex conjugate leads to the coupled equations $$\begin{aligned}
          0&=&\Big\lbrack(E_N+\mu)^2-\sigma_N-m^2-
V_{tree}'-V_{tree}''
             |\bar{\Phi}|^2\Big\rbrack A_N\nonumber\\
                &&\quad\quad\quad-\bar{\Phi}^2V_{tree}''B_N,
       \Omega_{free}&=&-2\pi^{-(D+1)/2}\Gamma\Big((D+1)/2\Big)
           \zeta_R(D+1)T^{D+1}\theta_0\nonumber\\
          &&-\pi^{-(D+1)/2}\Gamma(D/2)\zeta_R(D)
T^D\theta_{1/2}\nonumber\\
          &&-\frac{1}{2}\pi^{-(D+1)/2}\Gamma
\Big((D-1)/2\Big)\zeta_R(D-1)
           T^{D-1}\nonumber\\
         &&\quad\times\Big\lbrace\theta_1-\Big\lbrack
m^2-(D-1)\mu^2
        \Big\rbrack\theta_0\Big\rbrace+\cdots\label{eq:5.12}\end{aligned}$$ for $D\ge3$.

If we consider only $D=3$, and use $\theta_0=V$, then $$\frac{\partial}{\partial m^2}\Omega_{free}
=\frac{1}{12}T^2V+\cdots
          \label{eq:5.13}$$ and so from (\[eq:5.10\]) $$\Omega_1=\frac{1}{12}T^2V\delta M^2+\cdots\;.\label{eq:5.14}$$ We therefore have found the high temperature expansion $$\begin{aligned}
          \Omega&=&-\frac{\pi^2}{45}VT^4-\frac{1}{2}\pi^{-3/2}
\zeta_R(3)
            T^3\theta_{1/2}\nonumber\\


set of interacting complex scalar fields with a rigid gauge invariance under the action of $G$.

Let $\Phi$ denote the set of complex scalar fields transforming under some $d_s$-dimensional representation of $G$. We can write $$\Phi\rightarrow U\Phi\label{eq:8.1}$$ where $$U=\exp(i\theta^iT_i)\label{eq:8.2}$$ with $T_i$ the hermitian generators for the Lie algebra of $G$ taken in the $d_s$-dimensional representation for the scalar fields. We will use $i=1,2,\ldots,d_G$ where $d_G  $ is the dimension of $G$, and $\alpha=1,2,\ldots,d_s$. Because we choose to work with complex fields rather than real fields here, the action is $$S=\int dt\int_{\Sigma}d\sigma_x\Big\lbrace(\partial^\mu
\Phi^\dagger)
           (\partial_\mu\Phi)-m^2\Phi^\dagger\Phi-\xi
R\Phi^\dagger\Phi-V_{tree}\Big\rbrace\label{eq:8.3}$$ where $\Phi$ may be regarded as a column vector of complex scalar fields with $d_s$ components. $V_{tree}$ is assumed to be invariant under (\[eq:8.1\]), and for         \mu^j\Phi^\dagger T_j)(\dot{\Phi}-\mu^j
 T_j\Phi)+|\nabla\Phi|^2\nn\\
          &&\quad+(m^2+\xi R)|\Phi|^2+V_{tree}\rbrace\label{eq:8.26}\end{aligned}$$ after the Wick rotation to imaginary time. We will define $$\bar{S}_{int}=\int_{0}^{\beta}dt\int_\Sigma d\sigma_x
\lbrace\mu^j
                (\Phi^\dagger T_j\dot{\Phi}-\dot{\Phi}^\dagger T_j\Phi)
                 -\mu^j\mu^k\Phi^\dagger T_jT_k\Phi\rbrace\label{eq:8.27}$$ as the interaction part of the action. We are therefore perturbing around the $\mu=0$ result for which we know the thermodynamic potential already from Sec. 7.1.

Up to second order in the interaction we have $$\Gamma=\langle\bar{S}_{int}\rangle-\frac{1}{2}\langle
                \bar{S}_{int}^2\rangle\label{eq:8.28}$$ where terms denoted by $\langle\cdots\rangle$ are to


           +k^2+m^2\right\rbrack^{-1}\nn\\
          &=&\delta_{\alpha\beta}T(4\pi)^{-D/2}(2\pi T)^{D-2}
\Gamma(1-D/2)\nn\\
          &&\quad\times\left\lbrace\left(\frac{m}{2\pi T}\right)^{D-2}
             +2\sum_{n=1}^{\infty}\left\lbrack n^2+
      \left(\frac{m}{2\pi
 T}\right)^2\right\rbrack^{D/2-1}\right\rbrace\;.\label{eq:8.32}\end{aligned}$$ For high $T$, taking $D\rightarrow3$ it is easily seen from (\[eq:8.32\]) that $$G_{\alpha\beta}(x,x)\simeq\frac{1}{12}T^2\delta_{\alpha\beta}\;.
\label{eq:8.33}$$ This leads to $$\langle\bar{S}_{int}\rangle\simeq-\frac{1}{12}TV
                 \mu^i\mu^j\,{\rm tr}(T_iT_j)\label{eq:8.34}$$ as the leading contribution at high temperature.

The Wick reduction of the second term in (\[eq:8.28\]), keeping only the part quadratic in the chemical potential, results in $$\begin{aligned}
          \langle\bar{S}_{int}^2\rangle&=&4\mu^i\mu^j
 Commission in a rulemaking proceeding. Incentive Per Diem Charges - 1968, Ex parte No. 252 (Sub-No. 1), 337 I. C. C. 217 (1970). They challenged the order of the Commission on both substantive and procedural grounds. The District Court sustained appellees' position that the Commission had failed to comply with the applicable provisions of the Administrative Procedure Act, 5 U.S.C. 551 et seq., and therefore set aside the order without dealing with the railroads' other contentions. The District Court held that the language of 1 (14) (a)
1
of the Interstate Commerce
[410
U.S. 224, 226]
Act, 24 Stat. 379, as amended, 49 U.S.C. 1 (14) (a), required the Commission in a proceeding such as this to act in accordance with the Administrative Procedure Act, 5 U.S.C. 556 (d), and that the Commission's


1966 commenced an investigation, Ex parte No. 252, Incentive Per Diem Charges, "to determine whether information presently available warranted the establishment of an incentive element increase, on an interim basis, to apply pending further study and investigation." 332 I. C. C. 11, 12 (1967). Statements of position were received from the Commission staff and a number of railroads. Hearings were conducted at which witnesses were examined. In October 1967, the Commission rendered a decision discontinuing the earlier proceeding, but announcing a program of further investigation into the general subject.

In December 1967, the Commission initiated the rulemaking procedure giving rise to the order that appellees here challenge. It directed Class I and Class II line-haul railroads to compile and report detailed information with respect to freight-car demand and supplyconference was sent to all parties to the proceeding before the Commission.

The results of the information thus collected were analyzed and presented to Congress by the Commission during a hearing before the Subcommittee on Surface Transportation of the Senate Committee on Commerce in May 1969. Members of the Subcommittee expressed dissatisfaction with the Commission's slow pace in exercising the authority that had been conferred upon it by the 1966 Amendments to the Interstate Commerce Act. Judge Simpson in his opinion for the District Court said:

"Members of the Senate Subcommittee on Surface Transportation expressed considerable dissatisfaction with the Commission's apparent inability to take effective steps toward eliminating the national shortage of freight cars. Comments were general that the Commission was conducting too many hearings and taking too little action.


hearing requirements of the section neither expressly nor by implication. We know of no reason to think that an administrative agency in reaching a decision cannot accord consideration to factors such as those set forth in the 1966 amendment by means other than a trial-type hearing or the presentation of oral argument by the affected parties. Congress by that amendment specified necessary components of the ultimate decision, but it did not specify the method by which the Commission should acquire information about those components.
5
[410
U.S. 224, 236]

Both of the district courts that reviewed this order of the Commission concluded that its proceedings were governed by the stricter requirements of 556 and 557 of the Administrative Procedure Act, rather than by the provisions of 553 alone.
6
The conclusion of the DistrictCourt for the Middle District of Florida, which we here review, was based on the assumption that the language in 1 (14) (a) of the Interstate Commerce Act requiring rulemaking under that section to be done "after hearing" was the equivalent of a statutory requirement that the rule "be made on the record after opportunity for an agency hearing." Such an assumption
[410
U.S. 224, 237]
is inconsistent with our decision in Allegheny-Ludlum, supra.

The District Court for the Eastern District of New York reached the same conclusion by a somewhat different line of reasoning. That court felt that because 1 (14) (a) of the Interstate Commerce Act had required a "hearing," and because that section was originally enacted in 1917, Congress was probably thinking in terms of a "hearing" such as


(14) (a) of the Interstate Commerce Act. Appellees, both here and in the court below, contend that the Commission procedure here fell short of that mandated by the "hearing" requirement of 1 (14) (a), even though it may have satisfied 553 of the Administrative Procedure Act. The Administrative Procedure Act states that none of its provisions "limit or repeal additional requirements imposed by statute or otherwise recognized by law." 5 U.S.C. 559. Thus, even though the Commission was not required to comply with 556 and 557 of that Act, it was required to accord the "hearing" specified in 1 (14) (a) of the Interstate Commerce Act. Though the District Court did not pass on this contention, it is so closely related to the claim based on the AdministrativeProcedure Act that we proceed to decide it now.
[410
U.S. 224, 239]

If we were to agree with the reasoning of the District Court for the Eastern District of New York with respect to the type of hearing required by the Interstate Commerce Act, the Commission's action might well violate those requirements, even though it was consistent with the requirements of the Administrative Procedure Act.

The term "hearing" in its legal context undoubtedly has a host of meanings.
7
Its meaning undoubtedly will vary, depending on whether it is used in the context of a rulemaking-type proceeding or in the context of a proceeding devoted to the adjudication of particular disputed facts. It is by no means apparent what the drafters of the Esch Car Service Act of 1917, 40 Stat. 101, which


or contracts.

"(b) General notice of proposed rule making shall be published in the Federal Register, unless persons subject thereto are named and either personally served or otherwise have actual notice thereof in accordance with law. The notice shall include -

"(1) a statement of the time, place, and nature of public rule making proceedings;

"(2) reference to the legal authority under which the rule is proposed; and

"(3) either the terms or substance of the proposed rule or a description of the subjects and issues involved.
[410
U.S. 224, 227]
Except when notice or hearing is required by statute, this subsection does not apply -

"(A) to interpretative rules, general statements of policy, or rules of agency organization, procedure, or practice; or

"(B) when the agency for good cause finds (and incorporates the finding and afiled in the proceeding, constitutes the exclusive record for decision in accordance with section 557 of this title and, on payment of lawfully prescribed costs, shall be made available to the parties. When an agency decision rests on official notice of a material fact not appearing in the evidence in the record, a party is entitled, on timely request, to an opportunity to show the contrary."

"(a) This section applies, according to the provisions thereof, when a hearing is required to be conducted in accordance with section 556 of this title.

"(b) When the agency did not preside at the reception of the evidence, the presiding employee or, in cases not subject to section 554 (d) of this title, an employee qualified to preside at hearings pursuant to section 556


necessary to meet the statutory standards." 332 I. C. C. 11, 16. A subsequent study of boxcar supply-and-demand conditions (32 Fed. Reg. 20987) yielded data that were compiled in an interim report containing tentative charges and that were submitted to the railroads for comment. 337 I. C. C. 183. Although the Commission was admittedly uncertain whether its proposed charges would accomplish the statutory objective, id., at 191, and even though "the opportunity to present evidence and arguments" was contemplated, id., at 183, congressional impatience militated against further delay in implementing 1 (14) (a).
2
Consequently, the Commission rejected the requests of the appellees and other railroads for further hearings and promulgated an incentive
[410
U.S. 224, 249]
per diem rate schedule for standard boxcars. 337 I. C. C. 217.

Appellees then brought this actionthe case is inapposite because the hearings provided in this case do not "suffer from the defect found to be fatal in Morgan" - i. e., the parties were "fairly advised" of the scope and substance of the Commission proceedings. In Morgan II, however, there was no question that a "full hearing" included the right to present oral testimony and argument.
304
U.S. 1, 18
-20.
[410
U.S. 224, 257]


and off-balance, where they can't key on different formations and what we're doing, it's a plus for us."

The Stamps' off-season plan was to find a new return man, but the Houston native didn't even get a break in that special teams area.

He has done the job in the past -- 15 returns for 331 yards last season -- but proved to be just as valuable as anyone in that role.

"We had a scheme where we were just trying to get it up the middle and get some tough yards, and we were able to do that. We got some decent field position," he said.

"That's what you work in the off-season for. If you want to be a successful player and a player people want to come to theby both reducing nephron hyperfiltration and deactivating certain adaptive stimuli which occur in the setting of reduced nephron numbers^[@CR35]^. Moreover, they noted that an incremental approach to the transitioning of patients from CKD to dialysis may make the patients more receptive to treatment, as it would provide a better quality of life without interfering with their daily activities.

Our findings confirm previous studies that younger age is associated with a rapid decrease in RRF^[@CR1]^. In particular, patients initiating PD after kidney transplant failure also suffered a relatively rapid loss in RRF^[@CR36],[@CR37]^, probably as a consequence of cessation of immunosuppression and associated inflammation^[@CR37]^.

The strengths of this study include its relatively large cohort and inclusiveness. We included all incident CAPD patients during the study period in our PD unit. Developing a


behavior of autonomous driving basically in comparison with the classical ACC model (\[ACC\_General\]).

Simulations of string instability of ACC-vehicles are shown in Fig. \[Eco\_ACC\] (c). Speed disturbances in traffic flow consisting of 100$\%$ ACC-vehicles occur at an on-ramp bottleneck at which on-ramp inflow with the rate $q_{\rm on}$ and upstream flow with the rate $q_{\rm in}$ merge. String instability of ACC-vehicles leads to the emergence of moving jams upstream of the bottleneck (Fig. \[Eco\_ACC\] (c)). Contrarily, at the same set of the flow rates $q_{\rm on}$ and $q_{\rm in}$ as well as the same other model parameters [*no*]{} string instability of any platoon of the TPACC-vehicles is realized: In Fig. \[Eco\_ACC\] (d), all speed disturbances occurring at the bottleneck decay upstream of the bottleneck. It turns out that as long as timeheadway between TPACC-vehicle is within the range (\[TPACC\_main\_range\]), speed disturbances decay over time. This is because within this range the acceleration (deceleration) of TPACC-vehicle does not depend on time headway.

![Speed disturbances at on-ramp bottleneck in stable free flow with 100$\%$ autonomous driving vehicles for classical ACC model (\[ACC\_General\]) (see a version of ACC model with discrete time used for simulations in [@Kerner_Review3_Aut]) (a–c) and for TPACC model (\[TPACC\_main\])–(\[next2\_TPACC\]) (d–g): (a, d) Speed in space and time. (b, e) Fragments of vehicle trajectories; (b) is related to (a) and (e) is related to (d). (c, f, g) Microscopic speeds along vehicle trajectories shown by, respectively, the same numbers in (b, e); (c) is related to (b) and (f, g) are related to (e); (f) and (g) show the same speed


on the main road. To satisfy the desired time headway $\tau^{\rm (ACC)}_{\rm d}$, ACC-vehicle 2 should decelerates to a lower speed than the minimum speed of ACC-vehicle 1. This deceleration of ACC-vehicle 2 forces the following ACC-vehicle 3 to decelerate while approaching ACC-vehicle 2. Simulations show that the occurrence of large speed disturbances at the bottleneck is a basic problem of ACC-vehicles based on the classical approach in which the ACC-vehicles try to reach a desired time headway $\tau^{\rm (ACC)}_{\rm d}$.

These large speed disturbances at the bottleneck caused by ACC-vehicles (Fig. \[Fluc\_ACC\] (b, c)) do not occur in traffic flow consisting of TPACC-vehicles (Fig. \[Fluc\_ACC\] (d–g)). This is because within the range of time headway (\[TPACC\_main\_range\]) the acceleration (deceleration) of an TPACC-vehicle does not depend on time headway. This explainsLAS VEGAS -- Malachi Flynn scored all of his 28 points after halftime to lead San Diego State past Iowa 83-73 as the Aztecs rallied from a 16-point first-half deficit in Las Vegas Invitational championship game on Friday night.

Flynn, the tournament's MVP, also had five rebounds and four assists while going 9 of 9 from the free-throw line.

Jordan Schakel and Yanni Wetzell each had 14 points for the Aztecs (8-0) -- their best start since 2010-11, when they were also was 8-0.

CJ Fredrick led Iowa (5-2) with 16 points. Connor McCaffery added 15 and Joe Toussaint had 13. Luka Garza, who is averaging over 20 points per game, had nine points on 3-for-8 shooting and eight rebounds.

San Diego State took the lead for good on Wetzell layup with


their operation. Due in part to the large amount of heat generated, these servers are typically rack mounted and cooled via fans built on the devices and a large system of fans attached to or placed directly behind, or adjacent to, the rack of servers. As the need for access to greater and greater processing and storage resources continues to expand, limitations arise surrounding available space for expansion, building and equipment costs, and communication latency. This trend creates a need to increase the density of server systems (i.e., the amount of processing power and/or storage placed on a single server, the number of servers placed in a single rack, and/or the number of servers and/or racks deployed on a single server farm. With the increasing processing and/or storageIntroduction {#S1}
============

Neuronal activity in functional--morphological studies is frequently assessed by quantitation of immediate early gene (IEG) products. For instance, FOS ([@B65]) and FOSB ([@B7]) are widely used tools to test if neurons react by changes at transcriptional level to various stimuli (for reviews see [@B38], [@B39]). These proteins are products of the *Fos* proto-oncogene family and contribute to the modulation of gene expression as subunits of the well-known transcription factor activator protein 1 (AP1). *Fos* is a commonly used neuronal activity marker to study the acute neuronal response that occurs minutes after the stimulus at mRNA level ([@B67]). At protein level, FOS peaks 2 h after the stimulus ([@B39]) and finally returns to baseline in 4--6 h ([@B71]).

Another member of this protein family is FOSB. *FosB* shows increase


(PBS, pH = 7.4) followed by 250 ml ice cold 4% formaldehyde solution in 0.2 M Millonig sodium-phosphate buffer (pH = 7.4) in 20 min. Finally, animals were decapitated and their brains were dissected and post-fixed in the same fixative for 72 h. Thymus and adrenals were also collected and weighed.

Thirty-micrometer coronal sections were cut between the optic chiasm and ponto-medullary transition using Leica Vibratome (Leica Biosystems, Wetzlar, Germany). Three series of sections each interspaced by 90 μm were collected into anti-freeze solution (30% glycerol, 20% ethylene-glycol, 0.1 M PBS) and stored on −20°C till further examination. Before starting the labeling, sections containing the PVN \[(−1.56 mm) to (−1.92 mm) to the Bregma\], CeA \[(−2.40 mm) to (−2.92 mm) to the Bregma\], and BNST \[+0.12 mm to (−0.24*p* \< 10^--5^). Tukey's *post hoc* test revealed that 1M, 1.5M, and 12M animals upon acute stress exposure showed significantly elevated CRF-FOS cell counts compared to their respective controls (*p* \< 0.0005). Spearman's correlation test ([Table 2](#T2){ref-type="table"}) verified a moderate negative correlation between PVN's CRF-FOS cell count and age (ρ = −0.61; *p* \< 0.0001, [Figure 1D](#F1){ref-type="fig"}). The ARS animals' PVN, CRF-FOS cell counts correlated with the CRF-FOSB cell counts (ρ = 0.76; *p* \< 10^--6^).

######

Summary of statistical results obtained by two-way analysis of variance (ANOVA).

  **Groups**          **Cells labeled for**   **Area**   **Two-way ANOVA**


                         0.28    \<0.05

The number of FOS or FOSB immediate early gene (IEG) product containing corticotropin-releasing factor (CRF) immunoreactive neurons of the paraventricular nucleus of the hypothalamus (PVN), the oval division of the bed nucleus of the stria terminalis (BNSTov) and central nucleus of the amygdala (CeA) was correlated with data depicted in the third column in acute restraint stress exposed rats. SSD, specific signal density.

### FOSB in the CRF Cells of the Paraventricular Nucleus {#S3.SS1.SSS2}

Analysis of variance ([Table 1](#T1){ref-type="table"}) revealed the main effect of stress (*F*~(1,78)~ = 89.17; *p* \< 10^--6^), age (*F*~(7,81)~ = 2.67; *p* \< 0.05), and their interactionplot **(B)** of the Spearman's correlation test illustrates that there is no age-related decline of the N of CRF-FOSB labeled cells in CVMS. Graph **(C)** illustrates the positive correlation between FOSB immunoreactivity and the CRF content of the FOSB ir PVN neurons. Boxed areas are depicted in higher magnification insets in the right bottom corner of the respective images. 3rd, third ventricle. Scale bar 100 μm.](fnagi-11-00274-g004){#F4}

### FOSB Immunoreactivity in the CRF Neurons of the Central Amygdala Upon Chronic Variable Mild Stress {#S3.SS2.SSS3}

The number of CeA cells co-localizing CRF and FOSB was affected by age (ANOVA: *F*~(5,63)~ = 3.93; *p* \< 0.005) only ([Table 1](#T1){ref-type="table"} and [Figure 5A](#F5){ref-type="fig"}). The age-related decline of FOSB ir was confirmed by the correlation test also (ρ = −0.58; *p* \< 0.005, [Figure 5B](#F5){ref-type="fig"}


Bed Nucleus of the Stria Terminalis Upon Chronic Variable Mild Stress {#S3.SS2.SSS4}

The assessment of CRF-FOSB ir in the BSNTov revealed that similar to the CeA, the number of CRF-FOSB double positive neurons was affected by age (*F*~(5,63)~ = 5.37; *p* \< 0.001; [Table 1](#T1){ref-type="table"}). Tukey's *post hoc* test found that the magnitude of CRF-FOSB cell count decreased with age ([Figure 6A](#F6){ref-type="fig"}). The latter statement was supported by the Spearman's correlation analysis also (ρ = −0.57; *p* \< 0.005, [Figure 6B](#F6){ref-type="fig"}). CeA and BNSTov CRF-FOSB cell counts correlated with each other (ρ = 0.81; *p* \< 0.00005) and the latter with the relative thymus weight (ρ = 0.60; *p* \< 0.005) also.

![FOS and FOSB immunoreactivity in the bed nucleus of the stria terminalis (BNSTov). Representative images, depicting the BNSTovand relative value and selects MBS and agencies that offer attractive yields to predicted average lives.

Oklahoma City-based Tom Johnson Investment Management is giving GW&K a run for its (investors’) money. Its Intermediate Fixed Income strategy has style flexibility that allows the portfolio to adapt in an effort to add value over a full market cycle.

“The investment process blends strategic macroeconomic analysis, tactical analysis and fundamental credit analysis in an effort to identify issuers with acceptable credit risk and favorable yields within attractive sectors of the market,” Envestnet | Prima’s analysts wrote in presenting the strategy as a finalist in the fixed-income category. “Robust fundamental credit analysis is conducted on all potential issuers and is supplemented with scenario analysis, credit default swap spread analysis, trend analysis, leveraged buyout scorecards


Resistance to ultraviolet light in Pseudomonas syringae: sequence and functional analysis of the plasmid-encoded rulAB genes.
The indigenous plasmids, pPSR1 and pPSR5, were each shown to confer resistance to ultraviolet light (UV) in Pseudomonas syringae (Ps) pv. syringae FF5. The UV-resistance (UVR) determinant was subcloned from a cosmid library of pPSR1, and sequence analysis revealed the presence of two ORFs, designated rulAB which are homologous to the Escherichia coli umuDC mutagenic DNA repair systems and other plasmid-encoded UVR operons. Amino acid (aa) alignments indicated that RulAB are most closely related to the RumAB proteins from plasmid R391, sharing 40.5% and 48.6% aa identity with RumA and RumB, respectively. UV sensitivity assays with the cloned rulAB genes indicated that the expression of UVR in Ps required a functional recA gene.as reported by Miyakura et al. \[[@CR12]\].

We propose that the *MLH1* polymorphism is an important risk factor for development of *MLH1* methylation but only in certain cellular environments such as sessile serrated adenomas and *BRAF* mutant colorectal cancers arising from sessile serrated adenomas. Collectively, these findings inform our understanding of the mechanism by which *MLH1* methylation can occur in the setting of serrated colorectal neoplasia. Understanding the implications of germline polymorphisms in the epigenetic modulation of gene expression may inform screening guidelines and risk stratification for patients with sessile serrated adenomas.

CIMP

:   CpG Island Methylator Phenotype

MSI

:   Microsatellite Unstable/Instability

MSS

:   Microsatellite stable

SSA

:   Sessile serrated adenoma

SSAD

:   Dysplastic sessile serrated adenoma

TSA

:   Traditional serrated adenoma

TSAD

:   Dysplastic traditional serrated adenoma

Not applicable.

Funding


shit!’”

It was so good, Gall thought the engineer who sent it might be pulling his leg.

“They sent us this little microphone and we did the same test, because we didn’t believe it,” he says, “We had the same experience. It was such a huge motivation for us to go on.”

Countless iterations and two years later, the X Mic has the potential to change the way that we hear outdoor audio in the future. And with many of the strides made by the development team trickling down to other Jabra products in the future, this tiny puck-shaped mic may well be a cornerstone for the next generation of audio products.

For its part, Jabra seems excited to continue to develop its cutting-edge device and to create increasingly better versions ofbecause I feel like it’s important to understand the motives of the trolls. And wow, these guys are persistent. The questions themselves are nasty and unpleasant and belittle the efforts of a friend and co-writer. This really makes me angry. But okay, here are my brief answers.

Q & A with a troll.

1). Did VICE fact check your work in any way?

Yes.*

*Journalism 101. If you ask a “yes/no” question, you will get a “yes/no” answer more often than not.

2. What was Angela Kubo’s contribution to this piece? Does she have any significant journalistic experience? Is she a 23 year old full-time employee of an accounting firm who you hired when she was working at a bar in Roppongi

Angela Kubo was an assistant editor at the Diplomat when I hired


model, for which $\chi=J^{-1}$, and hence plays the role of a spin “self-energy” matrix for the QAF. Obviously, the key assumption made in (\[dmft-ansatz\]) is that the $\vq$-dependence of this self-energy can be neglected. This approximation, which is likely to be reasonable when spatial correlations are short-ranged, is analogous to the assumption of a momentum-independent self energy made in the DMFT of correlated fermion models. Here however, the DMFT concept is extended on two accounts: the local ansatz is made on the spin correlation function rather than on a single-fermion quantity, and a plaquette rather than a single site is considered. Extensions of DMFT to clusters [@review; @cluster-dmft; @dca] and to (spin or charge) response functions [@ext-dmft1; @ext-dmft2; @qsg] have been considered separately before in different contexts. Combining        3D_m(\tau)G_s(\tau)G_t(\tau)G_t(-\tau),\\
\Sit(\tau) &=& 3D_m(\tau)G_t(\tau)G_s(\tau)G_s(-\tau).
\label{hartree}\end{aligned}$$ Then the local problem (for a given bath $(D_s,D_m)$) reduces to two coupled non-linear integral equations. The correlation functions are given by $$\begin{aligned}
\nonumber
\chi_s(\tau) &=& -\frac{1}{2}\,G_s(\tau)G_s(-\tau),\\
\chi_m(\tau) &=& 2\,G_s(\tau)G_s(-\tau)G_t(\tau)G_t(-\tau).
\label{chi-green}\end{aligned}$$ In practice, we use the following algorithm: we start with an initial guess for the bath $D_{s,m}$, and obtain the Green’s functions by iteration of eq. (\[hartree\]). We can then calculate the susceptibilities from (\[chi-green\]), as well as the self energies $\cS_{s,m}$. Inserting the latter into (\[scc-scalar\]) yields new $\chi_{s,m}$ and, in turn, the new baths $D_{s,m}^{\rm new}(\inun)=-\cS_{s,m}(\inun)/3 +
1/\chi_{s,m}(\inun)$.

We now discuss our findings when solving these coupled equations numerically. The first key observation is that a paramagnetic solution can be stabilized down to the lowest temperature we could reach, with no sign of


us.

P.W. Anderson, [ Mater. Res. Bull.]{} [**8**]{}, 153 (1973). C. Waldtmann, H.-U. Everts, B. Bernu, C. Lhuillier, P. Sindzingre, P. Lecheminant, L. Pierre, [ Eur. Phys. J. B]{} [**2**]{}, 501 (1998); P. Lecheminant, B. Bernu, C. Lhuillier, L. Pierre and P. Sindzingre, Phys. Rev. B [**56**]{}, 2521 (1997). R. Moessner and S. L. Sondhi, Phys. Rev. Lett., 1881 (2001); R. Moessner, S. L. Sondhi, E. Fradkin, cond-mat/0103396. C. Mondelli, H. Mutka, C. Payen, B. Frick, K.H. Andersen, [Physica B]{} [**284**]{}, 1371 (2000); C. Mondelli, [ PhD Thesis]{} (Grenoble, 2000, unpublished). A. Georges, G. Kotliar, W. Krauth, and M. Rozenberg, Rev. Mod. Phys. [**68**]{}, 13 (1996). A. Schiller and K. Ingersent, [ Phys. Rev. Lett.]{} [**75**]{}, 113 (1995) M. H. Hettler, A. N. Tahvildar-Zadeh, M. Jarrell, T. Pruschke, H. R. Krishnamurthy, [Phys. Rev. B]{} [**58**]{}, 7475 (1998). J. Lleweilun Smith and Q. Si, Phys. Rev. B [**61**]{}, 5184 (2000). R. Chitra and G. Kotliar, Phys. Rev. B [**63**]{},Sam G. Jacobs of Houma-Thibodaux, La., and appointed as his successor Auxiliary Bishop Shelton Fabre of New Orleans.

Bishop Jacobs, who has headed the diocese since 2003, is 75, the age which bishops are required by canon law to submit their resignation to the pope. Bishop Fabre, 49, has been a New Orleans auxiliary since 2006.


Development and validation of the Beliefs and Behaviour Questionnaire (BBQ).
To develop and validate a questionnaire to screen for potential nonadherence in patients with chronic ailments. Themes from qualitative interviews with chronic obstructive pulmonary disease patients were used in developing content of the questionnaire. The questionnaire was distributed to 525 ambulatory patients with chronic lung diseases. Principal components analysis was performed to identify the subscales in the questionnaire. Internal consistency, validity and stability of the subscales were also evaluated. The 30-item Beliefs and Behaviour Questionnaire (BBQ) measures beliefs, experiences and adherent behaviour on five-point Likert-type scales. Two hundred and eighty patients (53.3%) with a mean age of 71.1 years responded to the questionnaire. The 'beliefs' section had a two-factor solution-'confidence' and 'concerns' with internal consistencies of 0.82 and 0.45,   for ( var prop in filters ) {
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<?php

namespace Encore\Admin\Console;

use Encore\Admin\Admin;
use Illuminate\Console\Command;
use Illuminate\Support\Arr;

class ImportCommand extends Command
{
    /**
     * The console command name.
     *
     * @var string
     */
    protected $signature = 'admin:import {extension?}';

    /**
     * The console command description.
     *
     * @var string
     */
    protected $description = 'Import a Laravel-admin extension';

    /**
     * Execute the console command.
     *
     * @return void
     */
    public function handle()
    {
        $nav.data('size','small').stop().animate({
                        height:'40px'
                    }, 600);
                    $('.nav-collapse li a').css('height','40px');
                }
            } else {
                if ($nav.data('size') == 'small') {


to provide the key
records which had been
requests, including but not limited to:
[3]

According
to the CEC’s response, validity
and integrity of the
CEC’s IT
systems mostly depended on one person - Mr Lazar Dudovitch, whose
lawful appointment record the CEC
failed to provide. The CEC
also failed to provide the requested certification records,
pertaining to
validation of the systems by the same person.

The
CEC's
response tries to represent the publication of the election returns
in the CEC's
web site as an automatic, no human touch, one time only,
unchangeable process. The
CEC also failed to provide the requested documentation regarding the
person, under whose authority such information is published in the
CEC web site.
However, adulterations of the data on the CEC’s
web site have been repeatedly documented in
recent months...

The
CEC
claims in its response, “the
systems were
examined and certified by the authority [Shin Bet-Reem – jz]”,
but the
CEC
failed to provide anyHumnan Rights in Israel, with the note: "lack of integrity of the electronic records of the Supreme Court, the district courts and the detainees courts in Israel."

The United States

* "...it's difficult to find a fraud of this size on the U.S. court system in U.S. history... where you have literally tens of thousands of fraudulent documents filed in tens of thousands of cases." Raymond Brescia, a visiting professor at Yale Law School

* Los Angeles County is"the epicenter of the epidemic of real estate and mortgage fraud."FBI (2004)

* “…judges tried and sentenced a staggering number of people for crimes they did not commit."Prof David Burcham, Loyola Law School, LA (2000)

* “This is conduct associated with the most repressive dictators and police states… and judges must share responsibility when innocent