[Renal failure in the medicolegal evaluation of civil invalidity and social security disability (INPS)].
After a quick description of the anatomopathology and physiopathology of renal failure, the Authors delve into the problem of assessing its medicolegal aspects in the fields of civil invalidity and social security. In Italy, civil invalidity involves protecting the psychological and physical welfare of the disabled, as sanctioned by law 118 of 1971; this law protects all citizens with a debilitating condition, including those who do not work or are not of working age. A disabled person is someone who, if of working age (between 18 and retirement) has a reduction of more than ⅓ (34%) of their general work capacity; if under or over the retirement age, they have a persistent difficulty in carryingPosted: September 28, 2015 by

Last updated:

Tech support scammers launch the infamous fake Blue Screen Of Death via a Google AdWords malvertising campaign.

One of the major goals for any online business is to attract as many visitors as possible to their websites in order to generate more revenues.

This is typically where advertising comes into play, by helping companies to reach the right audience and converting those clicks and visits into actual sales.

Sadly, fraudulent businesses also use online advertising as a way to reel in potential victims. This is nothing new and we have seen many examples of targeted keywords on search engine results before.

Many times these rogue advertisers will abuse legitimate brands to trick people and provide services on behalf of these companies. Beyond copyright infringement laws, there is


and Glass v. Newbridge Securities" (1996). 1996 Decisions. Paper 92.
http://digitalcommons.law.villanova.edu/thirdcircuit_1996/92

This decision is brought to you for free and open access by the Opinions of the United States Court of Appeals for the Third Circuit at Villanova
University School of Law Digital Repository. It has been accepted for inclusion in 1996 Decisions by an authorized administrator of Villanova
University School of Law Digital Repository. For more information, please contact Benjamin.Carlson@law.villanova.edu.
                UNITED STATES COURT OF APPEALS
                    FOR THE THIRD CIRCUIT

                No. 95-1175, 95-1215,facts affecting
         the interest of the beneficiary which he
         knows the beneficiary does not know and which
         the beneficiary needs to know for his
         protection in dealing with a third person.
Restatement (Second) of Trusts § 173, comment d. (1959).
    We have never held that a request is a condition precedent
to such a duty regardless of the circumstances known to the
fiduciary. To the contrary, it is clear that circumstances known
to the fiduciary can give rise to this affirmative obligation
even absent a request by the beneficiary. "[T]he duty to
disclose material information 'is the core of


According to the Funds, the information Janney provided on
the NASD form indicates that Lloyd improperly handled his own
investments, fraudulently altered a commercial instrument and
lied about his actions. If Janney was a fiduciary, and if its
conduct would otherwise be a breach of fiduciary duties, it may
not hide behind Lloyd's departure to shield it from the
consequences of its actions.

                       IV. Common Law Duty
    The Funds argue: "to the extent [they] do not have a
statutory claim against Janney under ERISA, they do have such a
claim either under federal common law or under state common law."
See Brief of the Funds at 39. As noted earlier, the district
courtERBIL, Kurdistan Region — Citing religious rules, Turkey-backed Islamist factions in control of Afrin are systematically destroying cemeteries in the Kurdish enclave.

A resident of Afrin who wished to remain anonymous for fear of retaliation said that on Wednesday militants of the Free Syrian Army (FSA) removed tombstones from the graves in Edama village in the district.

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The tombs were also leveled. The militants told the residents that their reason was religious and the tombs were too high above ground and needed to be flattened.Last week, Turkey’s proxies also went to Meydanke village in the Shera district of Afrin under the same religious pretext, doing the same thing to that cemetery.In December, more than 500 tombs in Sinare village in the Shera district were destroyed by the militants. Their


the banner of the Peoples’ Protection Units (YPG).Since the takeover, half of the population has been living in camps. Their houses have been occupied and olive groves and factories taken over.Kurdish symbols — like the statue of Kawa the Blacksmith — have been destroyed, and streets and other places have been changed to Turkish or Arabic names. Kurdish has also been removed as an official language, replaced with Arabic and Turkish.The groups have committed human rights violations and engaged in looting. They have regularly destroyed cemeteries, each time citing different reasons. Claiming violation of religion is the latest trend.Melanocortin MC(4) receptor-mediated feeding and grooming in rodents.
Decades ago it was recognized that the pharmacological profile of melanocortin ligands that stimulated grooming behavior in rats was strikingly similar to that of Xenopus laevis melanophore pigment dispersion. After cloning of the melanocortin MC1 receptor, expressed in melanocytes, and the melanocortin MC4 receptor, expressed mainly in brain, the pharmacological profiles of these receptors appeared to be very similar and it was demonstrated that these receptors mediate melanocortin-induced pigmentation and grooming respectively. Grooming is a low priority behavior that is concerned with care of body surface. Activation of central melanocortin MC4 receptors is also associated with meal termination, and continued postprandial stimulation of melanocortin MC4 receptors may stimulate natural postprandial grooming behavior as part of the behavioral satiety sequence. Indeed, melanocortins


there is no consensus on the nature and even existence of the M phase, with a range of alternatives from its existence as uniform phase in a narrow composition range, the coexistence with the R phase in a broader range, or actually a fine mixture of R and T domains or finely twinned R domains behaving on the average as monoclinic. The debate has been recently reviewed [@Fra08b; @PSB08; @YZT09], and involves the mechanisms of rotation and switching of the polarisation.

The situation is confused also on the Zr-rich end of the phase diagram, where the ferroelectric R phase approaches the antiferroelectric orthorhombic one. Here electron, but not neutron or x-ray, diffraction experiments reveal superlattice peaks incompatible with the R structure, variously attributed to rotations of the O octahedra [@Vie95;@VLD96] or to antiferroelectric-like cation displacements away from the average $\left< 111 \right>$ direction [@RCW98; @WKR05].

Structural studies in these critical composition ranges face the problem of analysing structures of domains with very short coherence lengths and possibly of different coexisting phases, so that information from other techniques, although not providing direct information on the cell symmetry, may prove useful in clarifying some issues. We present anelastic and dielectric spectroscopy measurements, which provide new insight in these debates, and we attempt to rationalize the phase diagram of PZT regarding the tendency of the O octahedra to tilt.

Experimental and Results
========================

The ceramic samples of PbZr$_{1-x}$Ti$_{x}$O$_{3}$, with Ti fractions $x=0.1$, 0.14, 0.17,* *0.42, 0.45, 0.452, have been prepared similarly to a previous study [@127] with higher values of $x$ (0.455, 0.465, 0.48 and 0.53), with


were made at $0.5-1.5$ K/min between room temperature and 540 K in a Delta climatic chamber.

The mechanical analogue of the dielectric susceptibility is the elastic compliance $s=s^{\prime }-is^{\prime \prime }$, which was obtained as the reciprocal of the dynamic Young’s modulus $E\left( \omega ,T\right)
=E^{\prime }+iE^{\prime \prime }=s^{-1}$. It was measured between 100 and 750 K by electrostatically exciting the flexural modes of the bars suspended in vacuum on thin thermocouple wires [@135]. During a same run the first three odd flexural vibrations could be tested, whose frequencies are in the ratios $1:5.4:13.2$. The fundamental resonance angular frequency is [NB72]{} $\omega \propto \sqrt{E^{\prime }}$, and the temperature variation of the real part of the compliance is given by $s\left( T\right) /s_{0}\simeq $ $\omega _{0}^{2}/\omega ^{2}\left( T\right) $, where $\omega _{0}$ is chosenmay be affected by various processes, especially in the presence of strong domain wall relaxations, as is the case below the ferroelectric transition. When the temperature rate is such that the domain configuration is kept far from equilibrium, the susceptibility curve generally drops when the temperature rate is decreased and partial aging proceeds. This occurs also in certain temperature and composition ranges of PZT, where marked irregularities may be induced in the $s\left( \omega
,T\right) $ curves by varying the temperature rate. We will not discuss such phenomena, and only mention that they can be reduced by keeping the temperature rate as constant and low as possible, and their amplitude is larger at lower measuring frequency.

![Anelastic spectra of PZT 90/10 measured during heating. 1 (dashed): poled state, 1.8 kHz; 2


run parallel to each other below the step at $T_{\mathrm{T}}$, but the $x=0.14$ curve has a clear bump indicated by the arrow, whose precise shape is however difficult to evaluate. An even more attenuated anomaly might exist also for $x=0.17$, even closer to $T_{\mathrm{T}}$, but it is not actually distinguishable.

Compositions near the MPB
-------------------------

![Anelastic spectra of PbZr$_{1-x}$Ti$_{x}$O$_{3}$ with $x=0.1,$ 0.42, 0.455, 0.48 and 0.53 measured at $1-1.8$ kHz. The vertical lines mark $%
T_{\mathrm{T}}$, while the arrows the relaxation R$_{2}$ (the three highest $%
x$ are from reference [@127]).[]{data-label="fig TTvsx"}](fig5.eps){width="8.5"}

The measurements on the samples at higher Ti content are similar to those already published [@127] and a selection of them, including some from reference [@127], is presented in figure \[fig TTvsx\]. With increasing $x$, the anomaly at $T_{\mathrm{T}}$, marked by vertical lines, becomes moresymmetrical rhombohedral $a^{-}a^{-}a^{-}$ structure at intermediate compositions. Conforming to the above discussion, the $T_{\mathrm{T}}\left( x\right) $ line encloses the region of low tolerance factor, namely low $T$ and low $x$, possibly with some discontinuity when passing from the T to the R+M region, from $x>0.5$ down to $x=0.18$. At this point it does not prosecute to the maximum value at $%
x=0 $, but decreases sharply. The departure from the expected monotonic rise has been already noted and explained in terms of competition between the O AFE phase with $a^{-}a^{-}c^{0}$ tilt and the R FE phase; this would cause a frustration of the Pb displacements and consequently inhibit octahedral tilting, which is coupled with such displacements [@WKR05].

The presence of a phase transition at a $T_{\mathrm{IT}}\left( x\right) $merging with $T_{\mathrm{T}}\left(


the tilting transition, and the depression of the combined $T_{\mathrm{IT}}-T_{%
\mathrm{T}}$ line near $x=0.17$ is much less important than that of the $T_{\mathrm{T}}$ curve alone. The existence of coupling between tilts and polar modes is recognizable by the effect of the transition at $T_{\mathrm{T}}$ on the polarisation [@GMC78; @CNI97], and dielectric susceptibility [@VLD96] (see also the present data), by the reduction of the extrinsic contribution to piezoelectric effect in the tilted $R3c$ phase [@ER07] and is also indicated by first-principle calculations [@LCW02].

Nature of the intermediate phase below $T_{\mathrm{IT}}$
--------------------------------------------------------

We can only make conjectures on the nature of the transition at $T_{\mathrm{%
IT}}$ based on our susceptibility experiments. If it is indeed an initial stage of the rotations of the octahedra, it may be a tilt pattern intermediate between those of the O and R$_{\mathrm{L}}$and rather indicates the presence of a monoclinic phase, possibly stabilized by the internal random strains and coexisting with the rhombohedral one. The $T_{\mathrm{T}}\left(
x\right) $ line is also shown to be perfectly continuous up to the MPB, which, together with a smooth evolution of the anelastic spectra with varying composition, provides evidence against a clear border between rhombohedral and monoclinic phases, and rather confirms the recent structural studies where the two structures are found to coexist over a broad composition range.

The authors thank Mr. C. Capiani (ISTEC) for the skillful preparation of the samples, Mr. F. Corvasce (ISC), P.M. Latino (ISC) and A. Morbidini (INAF) for their technical assistance in the anelastic and dielectric experiments.

Jaffe B, Cook W R and Jaffe H 1971 [*Piezoelectric Ceramics*]{} (London: Academic Press)

Damjanovic


WHY

Of the 1,500 to 2,000 children killed each year by their caretakers, more than half die after they have come to the attention of child welfare agencies.

The Field Center brings together multiple disciplines and the nation’s foremost experts in child welfare to collaborate on reforming the systems that are responsible for protecting children.

Watch our video to see why the Field Center began its work on behalf of victims of child abuse and neglect.   margin-top 1rem
          line-height 1.5rem
          @media (min-width: $MQMobile + 1px)
            text-align left
      &.bigoudi
        flex-basis 24%
        align-items center
        .illustration
          display none
      @media (min-width: $MQMobile + 1px)
        &:first-child
          .illustration
            margin-top calc(266px -


4% company match comes to about $1,200 per year.  To get that you need to save $1,200 yourself, so your gross pay after retirement contributions is about $28,800.
Now you have an offer making $48,000.  If you take the new job, you can put $2,400 in retirement (to get to an equivalent retirement rate), and now your gross pay after retirement contributions is $45,600.
Now if the raise in salary were not as high, or you were getting a match that let you exceed the individual contribution max, the math might be different, but in this case you can effectively save the company match yourself and still be way ahead.
Note that there are MANY other factors that may also be applicable as to whetherto take this job or not (do you like the work? The company? The coworkers? The location? Is there upward mobility? Are the benefits equivalent?) but not taking a 67% raise just because you're losing a 4% 401(k) match is not a wise decision.

A:

4% of 30k ($1,200) is dwarfed by an $18,000 base pay increase. At 48k maxing out IRA will take ~11.5% of gross income, so at current position (30k salary) 401k contributions would likely be limited to the matching portion anyway.
The long-term benefit of a deferred tax retirement plan can't fully be known since tax rates can change over time. If rates increase, the benefit can be mitigated. Personally, I only contribute to 401k enough to get full employer matching, and then I prioritize HSA, IRA,


The Associated Press. "Most of the people who saw it were heading off to work in the dark, and say it lit up the ground like it was almost daylight."

Ronald Normandin was driving to work in Vacaville, Calif., when the fireball lit up the inside of his car.

"It looked like it was real close. It had a long streak of light, and the front part appeared to be huge and a squarish shape," he said.

Marnie Mattice, of Reno, said she was jogging with a friend when she saw the meteor light up the sky "kind of like lightning," then appear like "a very bright signal flare" in the distance.

"It wasn't symmetrical like a star, but more of an irregular circle. As it burned out, it left a trailhand bandaged. And that’s just the offstage drama. Onstage, Ochs played some of his beloved protest songs but also the standard “Mona Lisa,” Merle Haggard’s “Okie From Muskogee,” and medleys devoted to the work of Elvis and Buddy Holly.

Gunfight at Carnegie Hall was, for most purposes, the last of Ochs as a singer. He began to suffer from crippling writer’s block and equally crippling alcoholism. He traveled extensively (he was mugged in Tanzania, damaging his voice), became interested in Chilean politics, performed at a huge rally in Central Park in April 1975 when the Vietnam War ended. And then, the eternal darkness of madness: Ochs started telling people that he was a man named John Butler Train who had murdered the real Phil Ochs and taken his place.


Hello! Yes I can do Chibis. I actually have a separate sheet for chibis. My style of chibs has changed slightly (as the Overwatch chibs are over a year old now) but of you're wanting something similar to what I've done for the Overwatch ones then I can do (same price too)Send me a PM if you're interestedConversations We Need To Have

Learn Our Story: We Are Successful!

Thanks to the advances we have made from slavery to the Civil Rights Era; we have been left a remarkable gift by the highest achievers of our race. The gift is their stories of success. We all MUST learn about each of these successful people and many more if we are going to tap into ways that will lead to greatness. We need to understand that most, if not all, of the successful people in our race started with little or nothing. Yet, they were able to use what they had to achieve great things. If they could achieve success, why can’t we, with all of the resources we have in the 21st century, become successful too?

We all know


about Dr. Martin Luther King Jr. This is because he is one of the few African-American leaders we learn about in school. This is why there is an old joke that goes around about trying to answer a question about a successful black American. The “answer” is always Martin Luther King. Who was the first black American to run in a marathon? Don’t know? Say Martin Luther King!

It is a funny joke, but not because it makes you laugh. It’s funny because it is a true, yet very sad commentary on our knowledge of successful black people. We just don’t know enough about black pioneers and creators. There are thousands of books that contain the “secrets” of our race. We have autobiographies of black Americans such as BookerDouglas

Thurgood Marshall

Shirley Chisholm

Phyllis Wheatley

Mary McLeod Bethune

Sojourner Truth

Matthew Henson

W.E. B. Dubois

Granville T. Woods

Frederick Douglass

Bessie Coleman

After learning about these outstanding examples of success, we should not let our research about the achievements of African Americans stop here. These are only 20 out of millions of successful black Americans worldwide. Our race has produced some of the brightest, most creative minds in human history. We can learn volumes from these people and put their action plans to work immediately. The question is: are we as a race ready, willing, and able to use our heroes as our role models so our race can become successful?


cooperation can get firmly established, even in situations as the Prisoner\'s Dilemma game where defection is the dominant strategy in a well-mixed population [@pone.0090288-Weibull1], [@pone.0090288-McNamara1]. However, the emergence and spread of cooperation strongly depends on the learning rules governing the change of individual strategies on the basis of payoff comparisons [@pone.0090288-Perc2], [@pone.0090288-Szab2] and on the structure of the interaction network [@pone.0090288-Roca1], [@pone.0090288-Roca2]. As a rule of thumb, cooperation can get easily off the ground if the interaction network is heterogeneous (as in scale-free networks; [@pone.0090288-Santos1]), while it will not easily evolve in homogeneous networks (e.g. random-regular networks [@pone.0090288-Szab1]).

With a few exceptions [@pone.0090288-Ohtsuki1]--[@pone.0090288-Wu1], most network models implicitly assume that payoff comparisons with one or more interaction partners is the only factor inducing agents to change their strategy. In other1000 steps. Simulations run for much longer time periods revealed that within 10000 time steps stable levels of the relevant variables were reached that remained roughly constant over extensive periods of time. Technically speaking, these stable levels do not correspond to steady states, since in a finite population fixation on either *C* or *D* will eventually occur due to random drift. For practical purposes, this can however be neglected in populations of size as considered here. Therefore the simulation results obtained after 11000 time steps give a good indication of the balance of selective forces acting on *C* and *D*. All the simulation results reported below are averaged over 100 different realizations of different initial conditions and networks.

Payoffs {#s2b}
-------

We focus on two paradigm examples for the evolution of


attachment as described in [@pone.0090288-Barabsi1] and get its degree sequence. Then, these degrees are randomly given to the nodes of the target network and linked randomly according to the degree sequence. Different from the method in [@pone.0090288-Barabsi1], we can generate scale-free networks with the same degree distribution but different links. All results reported in this study are based on , yielding an average degree of 4. We used two different methods to achieve an incongruence between the interaction and the learning network. These methods will be explained below.

Simulation Results {#s3}
==================

Scenario 1: Overlapping interaction and learning environments {#s3a}
-------------------------------------------------------------

A natural way to study incongruences between interaction and learning neighbourhoods is to assume that individuals base their strategy-updating on payoff comparisons with part of their interaction neighbourhood and some additional individualsinteraction partners is mainly responsible for the fact that cooperation is more easily achieved in scenario 2. This does not only apply to the PDG but also to the SDG (compare the left panel of [Fig. 1](#pone-0090288-g001){ref-type="fig"} with the upper right panel of [Fig. 3](#pone-0090288-g003){ref-type="fig"}).

In all four panels of [Fig. 2](#pone-0090288-g002){ref-type="fig"} and [Fig. 3](#pone-0090288-g003){ref-type="fig"} the frequency of cooperation is positively related to the benefits of cooperation and negatively related to the incongruence between interaction and learning environments. In addition, the type of network has a marked effect on the evolution of cooperation. In both games, a much higher frequency of cooperation is achieved when the interaction network is scale-free than when it is random-regular. This is fully in line with earlier results indicating that cooperation is favoured by


, , , (player ), respectively. Consider again the case that used *C* and used *D* in the interaction phase. When denotes the number of cooperating interaction partners of , was represented in *CC*-pairs and in *CD*-pairs. If switches from *C* to *D*, this results in *CD*-pairs and in *DD*-pairs. Hence the change in \'s behaviour results in a loss of *CC*-pairs and a net change of *CD*-pairs. As above, we can now summarize the expected change in the frequencies of *CC* and *CD* pairs due to a potential learning event of a cooperator confronted with a defector who not interacted with :

Change in :

Change in :

\(d\) does not belong to the interaction network of (), but now used *D* and used *C* in the interaction phase. Completelyis favoured by large values of but hampered by a larger incongruence between the learning and the interaction network. Quantitatively, the pair approximation method predicts a lower degree of cooperation than the simulations. This is understandable, since the evolution and maintenance of cooperation reflects the emergence of spatial structure (clusters of cooperators). This structure can be potentially quite rich, and only part of it may be captured by the pair approximation method.

![Equilibrium level of cooperation as predicted by the analytical pair approximation method.\
As before, the degree of cooperation achieved in a Prisoner\'s Dilemma game (PDG, left) and in a Snowdrift game (SDG, right) is shown as a function of the benefit of cooperation and the incongruence between the interaction and the learning network. Since the pair approximation method


                  !(we[i] && we[j] && rwa[i] == rwa[j] && i != j),
                    ("Multiple ports(%x,%x) write to the same entry.", i, j)
                );
            end
        end

        for (genvar i = 0; i < PORT_NUM; i++) begin
            `RSD_ASSERT_CLK_FMT(
              end
        end

        for (genvar i = 0; i < READ_NUM; i++) begin
            always_comb begin
                rv[i] = rvBank[i][select[raReg[i]]];
            end
        end

    endgenerate

    // For Debug
    `ifndef RSD_SYNTHESIS
        Value debugValue[ENTRY_NUM];
        always_ff @(posedge clk) begin


 $readmemh(INIT_HEX_FILE, body.ram.array);
    endfunction

    function automatic void FillDummyData(string DUMMY_DATA_FILE, integer DUMMY_HEX_ENTRY_NUM);
        integer entry;
        for ( entry = 0; entry < body.ram.HEX_FILE_ARRAY_ENTRY_NUM; entry += DUMMY_HEX_ENTRY_NUM ) begin
            $readmemh(
                DUMMY_DATA_FILE,
                body.ram.array,
                entry, // Begin address
                entry + DUMMY_HEX_ENTRY_NUM -INDEX_BIT_SIZE = $clog2(ENTRY_NUM);
    typedef logic [INDEX_BIT_SIZE-1: 0] Address;
    typedef logic [ENTRY_BIT_SIZE-1: 0] Value;
    localparam ENTRY_BIT_WIDTH = $clog2(ENTRY_BIT_SIZE);

    // Since the hex file is read in 128 bits units, the memory array is also 128 bits units.
    localparam HEX_FILE_ENTRY_BIT_SIZE = 128;
    // Calculates the index width when the memory array is configured in 128 bits units from the bandwidth
    // ********-------   : 128 bits memory array (Actual memory array)
    // *********------  : 64 bits memory array (Externally visible memory array)
    // (Index)   (Offset)
    // The sum of the bit width of Index and Offset


input logic clk,
    input logic we,
    input logic [$clog2(ENTRY_NUM)-1: 0] wa,
    input logic [ENTRY_BIT_SIZE-1: 0] wv,
    input logic [$clog2(ENTRY_NUM)-1: 0] ra,
    output logic [ENTRY_BIT_SIZE-1: 0] rv
);

    // Request side
    localparam INDEX_BIT_SIZE = $clog2(ENTRY_NUM);
    typedef logic [INDEX_BIT_SIZE-1: 0] Address;
    typedef logic [ENTRY_BIT_SIZE-1: 0] Value;
    localparam ENTRY_BIT_WIDTH = $clog2(ENTRY_BIT_SIZE);

    // Since the hex file is read in 128 bits units, the memory array is also 128 bits units.
    localparam HEX_FILE_ENTRY_BIT_SIZE = 128;
    // Calculates the index width when the memory array is configured in 128 bits units from the bandwidth
       if (HEX_FILE_INDEX_BIT_SIZE > INDEX_BIT_SIZE) begin
            return {addr, count};
        end
        else begin
            return addr;
        end
    endfunction

    localparam HEX_FILE_ARRAY_ENTRY_NUM = 1 << HEX_FILE_INDEX_BIT_SIZE;
    (* ram_style="block" *)
    HexArrayValue array[HEX_FILE_ARRAY_ENTRY_NUM];

    Address raReg;
    HexArrayIndex hexFileRA[HEX_BLOCK_FILL_NUM];
    HexArrayValue hexFileRV[HEX_BLOCK_FILL_NUM];

    HexArrayIndex hexFileWA[HEX_BLOCK_FILL_NUM];
    HexArrayValue hexFileWV[HEX_BLOCK_FILL_NUM];

    always_ff @(posedge clk) begin
        if (we)


       end
    endgenerate

    // For Debug
`ifndef RSD_SYNTHESIS
    Value debugValue[ENTRY_NUM] /*verilator public*/;
    always_ff @(posedge clk) begin
        for (int i = 0; i < WRITE_NUM; i++) begin
            if (we[i])
                debugValue[ wa[i] ] <= wv[i];
        end
    end

    generate
        for (genvar i = 0; i < READ_NUM; i++) begin
            `RSD_ASSERT_CLK_FMT(
clk,
    input  logic we[WRITE_NUM],
    input  logic [$clog2(ENTRY_NUM)-1: 0] wa[WRITE_NUM],
    input  logic [ENTRY_BIT_SIZE-1: 0] wv[WRITE_NUM],
    input  logic [$clog2(ENTRY_NUM)-1: 0] ra[READ_NUM],
    output logic [ENTRY_BIT_SIZE-1: 0] rv[READ_NUM]
);
    localparam INDEX_BIT_SIZE = $clog2(ENTRY_NUM);
    typedef logic [INDEX_BIT_SIZE-1: 0] Address;
    typedef logic [ENTRY_BIT_SIZE-1: 0] Value;

    localparam BANK_NUM_BIT_WIDTH = $clog2(READ_NUM > WRITE_NUM ? READ_NUM : WRITE_NUM);
    localparam BANK_NUM = 1 << BANK_NUM_BIT_WIDTH;

    generate
        if (BANK_NUM >= 2) begin
            DistributedMultiBankRAM_ForGE2Banks#(ENTRY_NUM, ENTRY_BIT_SIZE, READ_NUM, WRITE_NUM)


         );
            end
        end
    endgenerate

endmodule : DistributedMultiBankRAM_ForGE2Banks

//
// --- Block RAM consisting of multiple banks
// In a functional simulation, a bank conflict is detected as an error
//
module BlockMultiBankRAM #(
    parameter ENTRY_NUM = 64,
    parameter ENTRY_BIT_SIZE = 63,
    parameter READ_NUM  = 2,
    parameter WRITE_NUM = 2
)(
    input  logic clk,
    input  logic we[WRITE_NUM],
    input  logic [$clog2(ENTRY_NUM)-1: 0] wa[WRITE_NUM],
    input  logic [ENTRY_BIT_SIZE-1: 0] wv[WRITE_NUM],
                end
            end
        end

        for (int b = 0; b < BANK_NUM; b++) begin
            raBank[b] = ra[0]; // Don't care
            for (int i = 0; i < READ_NUM; i++) begin
                if (ra[i][BANK_NUM_BIT_WIDTH-1 : 0] == b) begin


  raBank[b] = ra[i];
                    break;
                end
            end
        end

        for (int i = 0; i < READ_NUM; i++) begin
            rv[i] = rvBank[0];  // Don't care
            for (int b = 0; b < BANK_NUM; b++) begin
           Introducing Let’s Talk Lit!

byC.K. Sample IIIon4/26/2009

You may not know this about me, but I have three degrees (from three different institutions) that I earned by reading and thinking and talking at length about books. Rather than let them go entirely to waste, I thought it would be fun to start a podcast about literature. It’s called Let’s Talk Lit!, and it’s now available via iTunes (direct link).

It’s rated explicit, because sooner or later, I’m sure I’ll end up cursing on it or quoting some text that curses violently. I may have a beer or two when recording, although I haven’t indulged while recording as of yet. I’m currently reading Don DeLillo’s Falling Man: A Novel. And the first real episode of the podcast (after the introduction podcast), spends


Field of the Invention
The present invention relates to a pressure reducing valve, which includes a piston that is displaceable depending on a pressure in a decompression chamber.
Description of the Related Art
As well known in the art, pressure reducing valves function to reduce the pressure of a high-pressure fluid to a given pressure. As one detailed example thereof, a pressure reducing valve of this type is disclosed in Japanese Laid-Open Patent Publication No. 2009-157692.
The pressure reducing valve disclosed in Japanese Laid-Open Patent Publication No. 2009-157692 includes a substantially rod-shaped piston disposed at an upward end of a valve element, a first helical spring, which applies a resilient biasing force to the valve element toward a valve seat (communication passage), and a second helical spring, which applies a resilient biasingBREAKING NEWS

BREAKING NEWS

Audubon To Hold Plant Exchange, Sale

What began as a mini-event to find homes for some of the Audubon Center & Sanctuary’s leftover herb garden plants has become a full-fledged event.

From 11 a.m. to 3 p.m. Saturday Audubon’s annual Plant Exchange and Sale provides an opportunity to meet other gardeners, to exchange extra and no-longer-needed plants from their home for others that suit them better while supporting Audubon.

Gardeners can visit the Audubon with plants in pots, no plastic bags, and exchange or buy plants and take them home. Labels including the name of the plant, color (if known) and sun/shade preference are appreciated. Audubon reserves the right to refuse invasive, ill-looking unspotted or other plants.

Plants are priced based on condition, species and size. Donations from local nurseries


Fraser D. Discussion of development processes in insect‐fungus association derived from the shaggy parasol fruiting on the nests of hairy wood ants. Ecol Evol. 2019;9:11619--11630. 10.1002/ece3.5611

1. INTRODUCTION {#ece35611-sec-0001}
===============

1.1. Rationale {#ece35611-sec-0002}
--------------

This paper describes an interdisciplinary, natural fungus‐insect‐rhizosphere interaction and presents both experimental attempts and discursive theory to elucidate some ecological processes and explanations. The discussions present a view on the development of: *Chlorophyllum rhacodes* as an inhabitant of ant nest mounds: habitat requirements (physical and nutritional, including specific enzymatic capabilities of the fungal tribe) and potential for associations.The potential effects of mycophagy in *Formica lugubris* in the light of mutualistic development models.

1.2. The observation {#ece35611-sec-0003}
--------------------

*Chlorophyllum rhacodes* (Vittadini) Vellinga (formerly *Macrolepiota rhacodes* (Vittadini) Singer, a.k.a. shaggy or reddening parasol mushroom) is an open woodland litter saprotroph (associated more with coniferthere were traces of a weak Hartig net. However, this was not as extensively developed as the ectomycorrhiza in the nests, which, therefore, could not be attributed to *C. rhacodes*. It can be concluded that *C. rhacodes* was simply a major component of the rhizosphere, deriving its resources from sources other than a full physiological mycorrhizal association, unless there was an artifact caused by the complex community interactions of this specific rhizosphere (examples discussed below).

The facilitation of *C. rhacodes* fruiting in the conditions provided by long‐term *F. lugubris* nests, which are invaded by tree roots, suggests a possible connection between *C. rhacodes* and established woodland communities. While nest mound material is frequently cycled throughout the mound structure, the material in the highly branched root network is effectively trapped. This physical stability allows for


large values of $\ycut$, $\ycut > 10^{-2}$, the NNLO corrections turn out to be very small, while they become substantial for medium and low values of $\ycut$. The maximum of the jet rate is shifted towards higher values of $\ycut$ compared to NLO, and is in better agreement with the experimental observation. The theoretical uncertainty is lowered considerably compared to NLO. Especially in the region $10^{-1}> \ycut > 10^{-2}$, which is relevant for precision phenomenology, one observes a reduction by almost a factor three, down to below two per cent relative uncertainty. Since the error band in this region is barely visible in the plot, we display the relative theoretical uncertainty $$\delta = \frac{\max_{\mu} (\sigma(\mu)) - \min_\mu (\sigma(\mu)) }
{2 \sigma (\mu = M_Z)}$$ at NLO and NNLO asan inset. The relative uncertainty on the LO calculation is constant at 10.2%.

The fixed-order NNLO description is still above the data at low jet resolution, where the convergence of the perturbative series is spoilt by large logarithms of $\ycut$ at all orders, and where a resummation should be carried out [@durham]. Furthermore, the theoretical parton-level prediction is compared to hadron-level data, thereby neglecting hadronization corrections, which may also account for part of the discrepancy.

To compute the jet rates with different multiplicities, it is more appropriate to normalize all jet cross sections to the total hadronic cross section corrected to third order [@kuhnrev] in the QCD coupling constant, ${\cal O}(\alpha_s^3)$. We consistently neglect numerically small QCD singlet contributions at this order, which were found to contribute at most one per cent [@kuhnrev]


study, we investigated the occurrence of CIASDH based on the existence of ASDH, which was easily clarified using the CT at admission. A previous study reported approximately 30% of patients developing CIASDH in children with ASDH.^[@B15]^ One-fifth to one-third of children with ASDH have the possibility of CIASDH.

The multivariate analysis in the present study revealed five predictors for CIASDH in children with ASDH: presence of seizure, consciousness disturbance at admission, absence of skull fracture, hematoma thickness ≥ 5 mm on CT, and midline shift ≥ 3 mm on CT. All the 12 children with CIASDH presented seizure, while seizure occurred in 13 of 45 children (22.9%) without CIASDH. The reported rates of seizure in non-accidental head trauma in children ranged from 40% to 79%.^[@B16],[@B17]^ Seizures have been reported                             0    Right       Focal

CIASDH: cerebral infarction following acute subdural hematoma, CT: computed tomography, F: female, L: left, M: male, R: right, SDH: subdural hematoma.

[^1]: **Conflicts of Interest Disclosure**

    All authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this article. All authors have registered online Self-reported COI Disclosure Statement Forms through the website for Japan Neurosurgical Society (JNS) members.


database pages were changed.  Any changed pages are backed up.  Thus you do a full restore, then the diff restore to add the modified pages.
3- What Is Your Bottleneck?
Bottleneck analysis is important to diagnose.  Are you backing up to the same disk array as your data files?  Are your data files being pegged?  What is your DISK SEC/READ and DISK SEC/WRITE for the data disks during backups?  I modified the backups to create 4 files.  Each file has it's own thread writer and in our SAN that worked out great.  Test it out, I shaved off 45 minutes by just creating 4 backup files.  Just make sure your disk metrics listed above are low.  Get a baseline. Neurophysiological and anatomical variability of the greater auricular nerve.
To study the normal variation in greater auricular nerve (GAN) conduction and anatomical course. GAN nerve conduction was studied in 77 healthy adults while 17 GANs were dissected in 10 cadavers. The largest sensory nerve action potentials (SNAP) were recorded when the stimulator was placed 6 or 7 cm from the external acoustic meatus (EAM). Amplitude decreased significantly with age (P = 0.001). The dissected GANs entered the subcutaneous layer between 55 and 105 mm (median 68 mm) from EAM. The postauricular branch was found in 13 of 17 cases. A large variation was observed both anatomically and by way of electrical stimulation. SNAP variation does probably reflect the anatomical variation in GAN course, branching, and terminal distribution. The best


1. Field of the Invention:
The present invention relates to novel cephem derivatives useful for anti-bacterial agents. More particularly, the present invention relates to 3-propenylcephem derivatives. The present invention also provides process for the preparation of the 3-propenylcephem derivatives, anti-bacterial agents, intermediates for the 3-propenylcephem derivatives, and process for the preparation of the intermediates.
2. Description of the Prior Art:
Cephem derivatives having ammonio group have been conventionally known from Japanese Patent Application Laid-open Nos. 174,387/83; 198,490/83; 130,295/84; 172,493/84; 219,292/84; 97,983/85; 197,693/85, 5,084/86, etc.
Particularly, cephem derivative having an ammoniopropenyl group at the 3-position thereof, similar to the compound of the present invention, have been disclosed in Japanese Patent Application Laid-open Nos. 172,493/84 and 5,084/86.to 2011, according to a peer-reviewed study by University of Wisconsin and Iowa State University economists.

Moreover, in a survey on ethanol taken earlier this year by the Renewable Fuels Association (RFA), 58% of consumers said they were very likely or somewhat likely to purchase E15.

That’s the good news for motorists. The less ebullient news about E15 is that even though EPA has approved the fuel, the states must also approve it. There are also some additional hoops it must jump through, such as approval by state fire marshals and state revenue departments.

At press time, E15 was approved in Iowa, Illinois and Kansas. Ethanol boosters are working with about 15 other states to allow the fuel to be legal, initially with ethanol-friendly states in the Midwest.

The reason, he says,


and her accompanying dice that make me love her in the current meta, it’s the way we play the game with her on our team, and that is more important to me in the deckbuilding process than anything else.

Tempo

Some of the best advice I’ve ever given was to DHaus from TheJediTrials a few days before worlds last year.

I love the kind of tempo we can have by rolling out Aayla first. While there are much fewer melee decks in the meta than in times past to set up big Force Misdirection plays, some of that is made up for by Aayla’s Indirect Damage side (there’s a ton more of THAT in the meta), and we can still set up Guard, Caution, and Aayla’s special, making her dice inThis type of activity is not normally done in production.
IF this type of operation is going to be put into production, it needs to thoroughly tested.  (What causes the most concern is the potential for the reset procedure to be accidentally performed at the wrong time, like, in the middle of the year.
Dropping and recreating the sequence is one approach.  As an operation, it's fairly straightforward as far as the SEQUENCE goes:

    DROP SEQUENCE MY_SEQ;
    CREATE SEQUENCE MY_SEQ START WITH 1 INCREMENT BY 1 MINVALUE 0;

[EDIT] As Matthew Watson correctly points out, every DDL statement (such as a DROP, CREATE, ALTER) will cause an implicit commit. [/EDIT]
But, any privileges granted on the SEQUENCE will be dropped, so those will need


to be re-granted.  Any objects that reference the sequence will be invalidated.  To get this more generalized, you would need to save privileges (before dropping the sequence) and then re-grant them.
A second approach is to ALTER an existing SEQUENCE, without dropping and recreating it.  Resetting the sequence can be accomplished by changing the INCREMENT value to a negative value (the difference between the current value and 0), and then do exactly one .NEXTVAL to set the current value to 0, and then change the INCREMENT back to 1.  I've used a this same approach before (manually, in a test environment), to set a sequence to a larger value as well.
Of course, for this to work correctly, you need to insure no other sessions referencePrognostic value of uterine artery Doppler velocimetry in growth-restricted fetuses delivered near term.
We have investigated the use of uterine artery Doppler waveform analysis in growth restricted fetuses delivered at > or =34 weeks. Included in the study were all consecutive euploid non-malformed singleton fetuses with accurate dating diagnosed as growth restricted (sonographic abdominal circumference <10th percentile) between January 1995 and December 1998 and who were delivered at > or =34 weeks. Delivery was expedited for biophysical profile 6 or less with nonreactive nonstress test, preeclampsia, oligohydramnios, absent fetal growth over 2 weeks, absent or reversed diastolic flow in the umbilical artery (UA), or UA pulsatility index (PI) greater than the 95th percentile after 37 weeks. Neonatal outcomes were compared in cases with normal versus abnormal Doppler waveforms at


new List<double>();

        foreach (var c in cross) {
            Console.WriteLine("x = " + c.x + " y = " + c.y);
            double res = c.x * c.y;
            Console.WriteLine("");
            LeftSide.Add(res);
        }

        double i = LeftSide[5] - LeftSide[7];
        double j = LeftSide[2] - LeftSide[6];
  Mohammad Dadkan

Dr. Mohammad Hossein Dadgan (born 2 February 1956 in Tehran, Iran) is a former
football player, having spent most of his playing career in Persepolis FC. He served as President of the Islamic Republic of Iran Football Federation from April 2002 until April 2006.

Early life
He was born on 2 February 1956 in Tehran, Iran. His family was from Tehran,He graduated in Phd from Tarbiat Modarres University  in 1980.

Footballing career

Club career
He started his footballing career in the now dissolved Bootan F.C. in Iran. Before long he moved to Persepolis F.C., one of the two Iranian powerhouses, and spent 8 years playing for Persepolis. He hung his boots at 27 and ended his career playing for Persepolis F.C.

International career
He was invited to the national team in 1978. He made


the meat

Whether you have bought ready-minced meat or steak to mince yourself, do not over process it or you will end up with a sticky paste and burger with a bouncy texture. If you are going for the real McCoy and have bought chuck steak, trim off gristle and sinewy bits, but keep the fat. Cut it into chunks and pulse in a food processor.

Be careful with the salt

Delia warns that if you add salt before cooking it will draw out the juices, drying the burger. She adds salt only after cooking, while Nigel Slater advises being frugal with it beforehand. If you can’t bear the thought of an unseasoned burger, take the advice of John Torode, who suggests adding Chinese Oyster Sauce to the raw mix instead.of that sum loudly applauds "sticking it to the rich" (the Tyranny of the Majority in full flower) while failing to note that the truly wealthy--the ones who don't have any earned income because they don't work in salaried jobs, the ones who own roughly half the nation's productive assets--pay nothing but a slice of their unearned income--much of which is protected by various tax breaks.

Complicity has consequences. This entire strategy of operating the State as a fiefdom for the Financial Power Elites--and by that I mean the people earning not $600,000, but those earning $600 million or more each a year--yes, they do exist-- and then buying the silence and complicity of the lower 60% with enough largesse to keep them quiet or at least distracted, has


 36   22   9   8    120   17.50   82.50
  Total 2012                                          23            32   20   8   13   122   18.85   81.15

These data demonstrated that readmissions for patients with pneumonia at each of the hospitals also involved a wide range of principal diagnoses. At each of the hospitals, a majority of readmissions were forsuggest that many patients who are subsequently readmitted are best characterized as medicine patients, with multiple diagnoses rather than a single one. This kind of description addresses the need to manage a wide range of conditions, rather than exacerbation of a single initial diagnosis. It will also require a broad approach to patient management, rather than a narrow focus of resources on a single admission diagnosis.

The same logic suggests the need for health care payers such as Medicare to characterize patients at risk of readmission with respect to medicine or other services, rather than individual diagnoses. As payers increase the number of diagnoses addressed by their programs, their target populations will probably utilize resources in the same manner as adult medicine or other clinical services. This will occur


care and double the funding for community health centers.

Hmm. Levaquin for "mild pneumonia"? Inappropriate abx or inaccurate disclosure? @washingtonposthttps://t.co/P08IuoQDZX — Matt Halfar, MD (@Mahal_Far) September 15, 2016

Clinton’s incident prompted new questions about both candidates’ openness regarding their health. Republican presidential nominee Donald Trump released a new letter from his doctor showing his blood pressure, cholesterol and medications, one day after Clinton made a public letter from her physician with similar information. Both doctors say their patients are fit to serve as president.But […]

Back in 2006, Natalie Portman produced a gangsta rap video for Saturday Night Live. It was crass, shocking and a whole lot of fun. Portman always had this non-threatening girl next door kind of aura and her role in Star Wars and her graduating from Harvard made her the kind of Hollywood starlet that was […]

Aleph Male beard balm is not just another small-batch, boutique-brand beard balm. It’s a celebration of Jewish sacred masculinity that hearkens back to ancient Jewish customs. The blends are also inspired by Jewish customs and essential oils with biblical references. Eitan Press, the founder of Aleph Male, is the passionate face and beard of the […]

Is it really coming out so soon? Who really knows. Apparently a big chunk of the funding


flute  (2000)
  Medea opera video for soloists, soft voice, choir, orchestra, instrumental solos and live electronics  (2000)
  Dedica. Praeludium Es moll for violin, flute, harpsichord or piano and cello  (2000)
  In Badia fiesolana 1980 n. 2, for chamber orchestra  (2002)
  Sospeso d’incanto N. 1 (with live electronics), for piano and live electronics  (2002)
  Grido ai miei occhi Sarajevo, for ensemble with piano, concertante guitar and electric bass (2002)
  Epifania dell’eterno, for solo violin  (2002)
  Suono a cielo aperto, for soprano and strings  (2002)
  In Badia fiesolana 1980 n. 1, for ensemble  (2002)
  La terra del tramonto Live-Symphony n. 1, for large orchestraCompared to past Tesla rollouts, the Model Y’s debut seemed to fall a little flat.

Billed as a sport utility vehicle, the Model Y in fact looks quite similar to Tesla Inc.’s Model 3 sedan, with a higher roofline and raised body.

There are a few differences — the Model Y is capable of carrying more passengers in some configurations, and more cargo. But while Tesla Chief Executive Elon Musk described the vehicle as having the “functionality of an SUV but it will ride like a sports car,” some analysts deemed it a conservative move by a company known for bold bets.

It was the lengthy delivery timeline — fall 2020 for a long-range, 300-mile version with a starting price of $47,000, and spring 2021 for the standard-range, 230-mile version that


8 Tesla CEO Elon Musk views the new Tesla Model Y at its unveiling in Hawthorne, Calif. on Mar. 14, 2019. (Frederic J. Brown / AFP/Getty Images) 6 / 8 The Tesla Model Y, a crossover sport utility vehicle based on the Model 3 sedan, introduced by Tesla CEO Elon Musk at the Tesla Design Studio in Hawthorne, Calif. on Mar. 14, 2019. (Tesla) 7 / 8 The Tesla Model Y, a crossover sport utility vehicle based on the Model 3 sedan, introduced by Tesla CEO Elon Musk at the Tesla Design Studio in Hawthorne, Calif. on Mar. 14, 2019. (Tesla) 8 / 8 The Tesla Model Y, a crossover sport utility vehicle based on the Model 3 sedan, introduced by Tesla CEO Elon Musk at the Tesla task: t,
              text: $(t).children('p.task-name').text().toUpperCase()
           };
}).sort(function(obj_a, obj_b) {
    obj_a.text.localeCompare(obj_b.text);

}).forEach(function(obj) {
    original_container.append(obj.task);
});

This assumes starredTasks is an actual Array. If it's a jQuery object, then do starredTasks.toArray().map(func....
The original_container represents a jQuery object that is the direct parent of the task elements.


in response to OP's comment and clarification)
What you want is a UNIQUE KEY (or INDEX) on the combined id and name fields - also known as a composite index (or key). The syntax for this is as follows:
CREATE TABLE Example2 (
    id INT NOT NULL,
    name VARCHAR(100) NOT NULL,
    UNIQUE KEY uix_example (id, name)
);

Duplicate ids with different names allowed to be inserted.
mysql> INSERT INTO Example2 VALUES(1, 'Peter Parker');
Query OK, 1 row affected (0.12 sec)
mysql> INSERT INTO Example2 VALUES(1, 'Billy Power');
Query OK, 1 row affected (0.08 sec)

Same name allowed to be inserted with different ids
mysql> INSERT INTO Example2 VALUES(1, 'Mary Hanlon');
Query OK, 1 row affected (0.06 sec)

mysql> INSERT INTO Example2 VALUES(2, 'Mary Hanlon');
Query OK, 1 row affected (0.06 sec)

But, whatdollars of extra funding.

It has struggled to attract headline concerts, with none, at this stage, booked for the 2014-15 year.

Since leaving the South Australian Cricket Association, Mr Davies has worked for Etihad Stadium, Melbourne, generating revenue through venue membership clubs, corporate hospitality and sponsorship.

At present, he is the event strategy manager at the South Australian Tourism Commission, reviewing its strategic plan for events, with responsibility for their commercialisation.

He was commercial manager and then deputy chief executive of the cricket association during a period when the Adelaide Oval became known as a national entertainment venue, hosting concerts by AC/DC, Pearl Jam, Fleetwood Mac and hosting the International Rugby Sevens.

A statement issued by DVML last night said Mr Davies saw it as a ''terrific challenge'' to ensure all DVML venues


  task.add_detail('')
    if since_step:
        task.add_detail('Skipping until step {}\n'.format(since_step))

def rollback_for_instances_full(groups, instances, task, step_current_method,
                                step_counter_method, step_manager=None):
    task.add_detail('\nSTARTING ROLLBACK\n')

    instances = instances or []
    current_step = step_current_method()
    steps_total = total_of_steps(groups, instances)
    since_step = (steps_total - current_step) + 1

    instances.reverse()
    result = steps_for_instances(
        groups, instances, task, step_counter_method,
        since_step, True, step_manager=step_manager
    )

 Introduction {#s1}
============

In recent years, genome-scale metabolic models, containing reactions catalyzed by enzymes encoded in an organism\'s genome, have been an emerging tool to study plant metabolic systems (Sweetlove and Ratcliffe, [@B73]; Seaver et al., [@B68]; de Oliveira Dal\'Molin and Nielsen, [@B13]). Genome-scale metabolic models are mathematical presentations of metabolism systems and they can be analyzed using computational approaches such as flux balance analysis (FBA) (Orth et al., [@B56]). This allows researchers to computationally explore possible and optimal behavior of plant metabolism (Yang and Midmore, [@B81]; Grafahrend-Belau et al., [@B29]; Poolman et al., [@B61]; Cheung et al., [@B8]; de Oliveira Dal\'Molin et al., [@B14]; Feller et al., [@B22]; Weraduwage et al., [@B79]). New biological insights about plants were gained using single cell metabolic models (Poolman et al., [@B62], [@B61];


to 3:1 in all phases (only leaf in the light is shown). Starch, glucose (Glc), sucrose (Suc), fructose (FRU), malate (MAL), fumarate (FUM), citrate (CIT), and nitrate ($\text{NO}_{3}^{-}$) were allowed to accumulate in the light and dark phases of leaf and root (dashed rectangle between light and dark where arrows indicate bidirectional storage). AA represents the 18 different amino acids. AA can be stored in the light and utilize in the dark. Exchange of AA, Suc, sulfate ($\text{SO}_{4}^{2 -}$), nitrate and phosphate (Pi) were allowed between leaf and root through the common pool using an active proton pump. Nitrate and photon uptake were allowed through root and leaf, respectively, at a maximum rate quantified by the corresponding tissue biomass. Uptake of other mineral nutrients ($\text{SO}_{4}^{2 -}$, Pi, etc.)The Sun’s Exotic Neighborhood

We think about our interstellar neighborhood in terms of stars, like Alpha Centauri and Tau Ceti, but the medium through which our relative systems move is itself a dynamic and interesting place. The Sun is currently passing through a shell of material known as the Local Interstellar Cloud. And that cloud is, in turn, located at the edge of a vast region known as the Local Bubble, scoured of material by supernova explosions in the nearby Scorpius-Centaurus and Orion Association star-forming regions. Within the past 105 years, the Sun emerged from the interior of the Local Bubble; it now moves obliquely in the direction of the high-density molecular clouds of the Aquila Rift, a star-forming region that itself reminds us how energetic ’empty’ space really


techniques. Please allow up to 3 weeks for your order to be shipped.

HERITAGE COLLECTION

The Kensington is made of the finest English bridle leather from one of the most prestigious leather producers in the world. This hand-curried leather is perfectly paired with gold buckles cast in solid brass from one of the oldest saddlery houses in Paris; a brass three-position Cheney folio lock from England completes what will undoubtedly be a favourite piece in your wardrobe for many years to come.
Colour: Light Havana
Dimensions : 11" x 9" x 3"
All natural vegetable tanned leather.
SUSTAINABLY MADE
Our natural vegetable tanned leather is responsibly sourced from a family owned tannery in England and is produced in small batches to minimize waste.
HANDCRAFTED
All of our leather goods are completely made by hand in our workshopQ:

Pandas, convert aggregated dataframe to list of tuples

I am trying to obtain a list of tuples from a panda's DataFrame. I'm more used to other APIs like apache-spark where  DataFrames have a method called collect, however I searched a bit and found this approach. But the result isn't what I expected, I assume it is because the DataFrame has aggregated data. Is there any simple way to do this?
Let me show my problem:
print(df)

#date       user            Cost
#2016-10-01 xxxx        0.598111
#           yyyy        0.598150
#


Pause to Admire Agra

A medieval city located on the banks of the Yamuna River in India, Agra was founded by Sultan Sikandar Lodi in 1506. Boasting three UNESCO World Heritage Sites, the Taj Mahal, Agra Fort and Fatehpur Sikri, Agra also impresses tourists with many other attractions which reflect the rich heritage of the city.

Taj Mahal is marked as a part of UNESCO World Heritage Sites and is one of the most majestic and famous buildings in the world. With its beautiful setting overlooking the River Yamuna, the Taj Mahal is a charming sight visible from Agra Fort. A symbol of love and dedication, it is the mausoleum of Shah Jahan’s favourite wife, Mumtaz Mahal, who died giving birth to her 14th child in 1631. If you planCity councilors clap back at fish farm critics

Public comments elicit heat from Harkness, Hurley

By Ethan Andrews | Jun 06, 2018

Courtesy of: Nordic AquafarmsBuildings constructed as part of a proposed land-based salmon farm would be limited to 45 feet under height limits adopted by the City Council June 5. Above is an artist's rendering of the fish farm as it might appear.

Belfast — A Wendell Berry poem might have been the last straw for city councilors, who laid into salmon farm opponents Tuesday night after they made comments equating approvals for the project with poisoning the land and killing children.

Nordic Aquafarms, a Norwegian company that hopes to build a $150 million aquaculture facility in Belfast, wasn't on the agenda Tuesday night, but the council did consider two zoning amendments


raised his voice as he berated the two fish farm opponents. "You speak for yourselves, not for the community," he said, adding that he believes a majority of people in Belfast support the Nordic Aquafarms project.

Councilor Mike Hurley called the public comments "disgusting" and "reprehensible."

He singled out Moesswilde, whom he accused of organizing a "mob" to attend the April 17 hearing, then coming back to complain that her campaign hadn't worked. The city councilor sarcastically thanked Byers for coming from Waldo to share his opinion.

"We are not murdering children here!" he barked at Byers. "You accuse us of mortal crimes; we are not guilty."

Other councilors took a softer stance, perhaps in an attempt to cool the debate. Councilor Eric Sanders told the opponents that the city councilors areIt is like someone coming into City Hall century's ago pitching an idea of wanting to use Cow Poop to make the vegetables we eat grow bigger. I bet the sky was falling down when that idea was first pitched too!!!

https://www.youtube.com/watch?v=Qs2BJGJfCK8

https://www.youtube.com/watch?v=pxp7SKs8GE4

Posted by: Neal Harkness | Jun 08, 2018 11:09

Mr. Hall, I have taken no polls or surveys, I can only present the evidence of my experience talking to people all over Belfast. It's rare that I can go to the store or walk down the street without someone stopping me to express their feelings about Nordic Aquafarms, and what the vast majority tell me is that they support the project.

They understand that economic development offers the only realistic means to achieve significant property tax relief. They reject the


his son was doing just fine.

'I don't know what else to do now'

"I had recorded a conversation with my son on the phone and I made the agent listen to it. His reaction was that my son was lying. He then asked his office boy to clear us from the room. I caught him by his collar and told him that I would now take legal action against him," Mukund says.

It was not an easy task. He had to run from pillar to post across the Punjab police machinery. His complaint was finally received late in July this year. The complaint is signed by 27 families. Eleven affected families from Himachal Pradesh and Punjab also submitted a complaint to the MEA.

Sixty-two-year-old Mangal Singh, the father of another trapped  scores = ensemble.predict(X_test)
        scores = pd.to_numeric(scores)
        accuracy = np.mean(y_test == [i for i in scores])
        assert_greater(
            accuracy,
            0.947,
            "accuracy should be greater than %s" %
            0.948)

        ensemble_with_options = EnsembleClassifier(
            num_models=3,
            sampling_type =


I have a lot of regrets about that, I feel that I’ve been the best mum that I can be.

“Growing my boys up was about keeping them out of jail, because I had a father who was a habitual criminal. I got through that – my boys are young men who work really hard for their families, they’re good, loving guys, and they’ve never seen the inside of a cell. That’s big. For me, that was big.

“There was so much for me to worry about other than thinking about [being abused]. I won’t say that I’m detached from that little girl but I don’t live in that pain.”

Talking about abuse is “everyday yarning,” for Link-Gordon but it is not commonly spoken about in Indigenous communities.

It’s not taboo buthowever, it is inconvenient to have to make the various mode settings from the control panel, particularly if the settings have to be made by complex button or key input procedures or by navigating through a complex set of menus.
Technology for setting the scanning mode and image processing mode automatically depending on whether the document is placed on a transparent document scanning table in the device or in an automatic document feeder (ADF) has been proposed in, for example, Japanese Unexamined Patent Application Number Nos. H11-308416 and 2000-33887. One scheme provides at least two scanning operation modes and changes the mode depending on whether the document is placed on the document scanning table or in the ADF; another scheme also takes the number of copies into consideration and


of photosyntetically-derived carbohydrates produced under stressful conditions [@pone.0007006-FondaUmani1], [@pone.0007006-Degobbis1] (e.g., P-limited diatoms that produce large amounts of polysaccharides [@pone.0007006-Myklestad1]--[@pone.0007006-Schuster1]) and through death and decomposition of cell-wall debris [@pone.0007006-Posedel1], [@pone.0007006-Sellner1]. Such a release can be coupled with a limited ability of prokaryotes to hydrolyze these exopolymers by means of extracellular enzymes [@pone.0007006-MullerNiklas1]--[@pone.0007006-Obernosterer1] leading to the release and accumulation of large molecular weight compounds in the system [@pone.0007006-Heissenberger1]--[@pone.0007006-FondaUmani2]. These processes can be associated with viral infections of prokaryotes and phytoplankton and the consequent cell lysis (viral shunt), which further contributes to release and accumulation of dissolved organic matter in the water column [@pone.0007006-Peduzzi1]--[@pone.0007006-Shibata1]. Whatever the causes triggering the formation of marine mucilage, this phenomenon has created increasing concern in coastal areas due to its socio-economical consequences.

Worldwide the highly productive and(as ratio between abundance in mucilage: abundance in seawater per unit of volume) ranging from 10^3^--10^4^. No other organisms entrapped in the mucilage were as enriched. The huge abundance of prokaryotes and viruses within the mucilage could be due to the ability of these large aggregates to entrap into free-living viruses and prokaryotes from the water column. In addition the mucilage represents a source of organic molecules potentially utilizable for sustain prokaryotic metabolism and growth. Typically viral and prokaryotic abundances in aquatic systems co-vary [@pone.0007006-Corinaldesi1]. This also occurred in marine mucilage where a significant correlation between prokaryote and viral abundance was observed (Spearman-rank correlation, r~s~ = 0.99; p\<0.001). The values of the ratio of virus-to-prokaryotic abundance in the mucilage (always \>17) were significantly higher than values typically reported for seawater


analyses {#s4d}
---------------------------------------------------

For the purposes of this research, we searched for mucilage and macro-aggregate (\>500 µm in size) records in oceans worldwide in published literature (Sciencedirect, ASFA). The research for mucilage records was also extended to include the whole of the Internet, to identify events not documented in scientific papers ([Table S1](#pone.0007006.s001){ref-type="supplementary-material"}). Annual mean data on Po river discharge (1990--2007) in the Adriatic Sea have been extracted from the Hydrological Annales of the Regional Agency for Prevention and Climate of the Emilia Romagna Region ([www.arpa.emr.it](http://www.arpa.emr.it)).

Quantitative differences in microbial variables between mucilage and seawater samples were tested using one-way analysis of variance (ANOVA). The type of substrate (mucilage vs. seawater) was treated as a fixed factor with two levels and significant differences were also assessed using a post-hoc Student-Newman-Kuels\' testHere are your next steps to find out more:1) Use the video below to start a conversation with your child about Baptism.

2) The baptism interview is an opportunity for the staff and volunteer leaders of Elevation to talk with your child about baptism and help you determine if your child is ready to be baptized. To request more information, please complete this form by clicking here.

We are excited to announce on April 29th, Elevation Church Kids is releasing its new worship album, One In A Million. These songs are born out of our church and produced by the same team as that of Elevation Worship’s latest album, Here As In Heaven. We believe these songs will resonate with you and your child and provide opportunities to sing and


and function of the CD20 molecule and the development of engineered anti-CD20 MAbs. CD20 MAbs mechanism of action include: complement-dependent cytotoxicity (CDC), programmed cell death, and Fc: FCR-dependent interactions, with passive immunization being a potential fourth mechanism \[[@B6-pharmaceuticals-03-03258]\]. Although it is widely accepted that Fc-Fc gamma receptor (FcgR) interactions are critical in follicular lymphoma, the role of the complement-dependent pathway and the mechanism of programmed cell death in other lymphoproliferative disorders are still disputed \[[@B6-pharmaceuticals-03-03258]\]. Rituximab is a chimeric murine-derived MAb that targets the CD20 antigen from the anti-CD20 antibody on the human constant region. Complement-mediated cell lysis is induced by rituximab. CD20 is a good target because of its high expression and the proximity of the AB binding epitope to the plasma membrane. After binding by MAbhad a higher over all response rates of 90%, compared with 77% for the fludarabine-only arm. The CR rate was 47% in the fludarabine plus rituximab arm and 28% in the fludarabine-only arm \[[@B20-pharmaceuticals-03-03258],[@B23-pharmaceuticals-03-03258]\].

Keating and colleagues designed a regimen of fludarabine, cyclophosphamide, and rituximab (FCR; fludarabine 25 mg/m^2^ and cyclophosphamide 250 mg/m^2^ daily for 3 days plus rituximab 375 mg/m^2^ on day 1 of cycle 1 and 500 mg/m^2^ on day 1 of cycles 2--6). This regimen was given to 177 patients with relapsed or refractory CLL \[[@B20-pharmaceuticals-03-03258]\]. Therapy with FCR was generally well tolerated and yielded an OR rate of 73%; CR was achieved by 25% of patients, of whom 32% also had a complete molecular response. Tam *et al.* \[[@B22-pharmaceuticals-03-03258]\] reported the results with the same


after a greater number of deaths occurred in the group of patients who received gemtuzumab ozogamicin compared with those receiving chemotherapy alone.

*Lintuzumab* is a humanized anti-CD33 MAb derived from the murine M195 antibody. Lintuzumab is similar to its murine parent M195 with respect to specificity, immunoreactivity, and internalization properties. However, lintuzumab has higher avidity than mouse M195, and, because the murine constant regions were replaced with human immunoglobulin sequences, it has the ability to mediate leukemia cell killing \[[@B44-pharmaceuticals-03-03258]\].

In phase I trials, immunotherapy with lintuzumab was well tolerated and produced objective responses in seven of 17 patients. Among 50 patients with relapsed or refractory AML, one PR and two CRs were achieved in patients with low marrow blast infiltration (5%--30%). In a phase III trial of lintuzumab (12to cause lymphopenia. Thirteen of 38 patients with mycosis fungoides and two of nine patients with Sezary syndrome developed dose-dependent CD4 lymphopenia and suffered infectious complications \[[@B55-pharmaceuticals-03-03258]\].

4.7. Anti-CD25 Antibody
-----------------------

*Daclizumab:* is an anti-CD25 antibody in which approximately 90% of the murine IgG2a has been replaced with the human IgG1κ sequence. This MAb has been approved for treatment of allograft rejection in combination with other agents. Many trial of this drug in HTLV-1-associated adult T cell lymphoma found some clinical benefit. In one study, of 19 patients given murine anti-Tac, 2 achieved a CR and four had a PR. To further test the killing ability of this MAb, murine anti-Tac was chelated onto the beta-emitting radioisotope Yttrium-90, and 18 patients with ATL were treated with this radio labeled antibody; two


time, the cabinet features a transparent liquid crystal screen, headphones, a 3D sound system and a ventilation system to immerse the player in his role of a sniper. The game has 3 different story modes, a score attack mode and a mission mode. You can watch the opening here.

Puyo Puyo Quest Arcade ver1.2 will be out in two days. Three new characters are added: Maguro Sasaki, Rider and Risukuma. Level limit is updated to 50. The new challenge mode allows a player to choose the game rules and try to make a high score. There are other new features including 10 new cards and the ability to save up to 3 games.

The popularity of the horse racing betting/management game from Sega does not weaken with age. The third       // Set up our CallbackHandler requests
        if (callbackHandler == null)
            throw new LoginException("No CallbackHandler specified");
        Callback callbacks[] = new Callback[9];
        callbacks[0] = new NameCallback("Username: ");
        callbacks[1] = new PasswordCallback("Password: ", false);
        callbacks[2] = new TextInputCallback("nonce");
        callbacks[3] = new TextInputCallback("nc");
        callbacks[4] = new TextInputCallback("cnonce");
        callbacks[5] = new TextInputCallback("qop");


Australia, thereby eliminating potential competitors. It is poised to do with rare earths what the Organization of Petroleum Exporting Countries has done with oil: make the world dependent. In 2002, China exported about 60,000 tons of rare-earth metals. In 2008, it exported about 45,000 tons. In 2009, based upon preliminary estimates, that will drop into the 30,000s.

The slide will most likely continue, with potentially serious implications for President Obama's energy goals. In 2008, an Australian analyst named Dudley Kingsnorth released a report in which he calculated that China's rare-earth supplies could become off limits to the world as early as 2012. The severity of Kingsnorth's projection has been questioned by some, and the global recession has probably pushed the date back a few years. But the general trendway to make magnets. Rather than use pure magnets, they developed a magnetic powder, which they could mix with rubber and inject where needed. This powder, like many high-performance magnets, required neodymium, a very strong rare earth. With the powder, less metal was needed, so car parts could be lighter—in the auto industry, a good thing. GM's magnet division got its own name, Magnequench, and a 175,000-square-foot facility was built in Indiana in 1986.

But the timing proved terrible. As the 1980s wore on, China's strip mining accelerated. Production soared, and global prices dropped. American magnet companies began to close down or, seeking cheaper resources, moved to China. In 1995, two Chinese companies, with the help of American investors, purchased Magnequench. The move, a report to Congress later found,


acquired the company. But many observers now believe China was also after something else: the Mountain Pass rare-earth mine, which Unocal had acquired in the 1990s. "I was getting phone calls from the highest levels of management at Unocal, asking what it would take to sell Mountain Pass," says Molycorp CEO Mark Smith. "I don't think it's too hard to put the two together."

Next was the incident in 2007 in which W.R. Grace and others felt squeezed by China's threat to withhold rare earth shipments. Then, in 2008, prices for all commodities, including rare earths, began to skyrocket. Neodymium jumped from $8 per kilogram to $50 per kg. Suddenly, people became concerned about the supplies of rare earths. The same year, a report by the National Research Council"You really have to understand this whole supply chain concept. I sit down with car companies and wind turbine companies, and the first response you will get is 'Oh, I don't worry about that. I buy my motors or generators from this company or that company and I didn't know there were rare earths in them.'" As Jack Lifton, a longtime metal analyst, says, "The Chinese are depending, as they always do, on the myopia of the American investment community that only sees to the end of its nose."

Some say the concerns are overblown, that China will do everything it can do to ensure steady exports. And for certain technologies, researchers say there are potential alternatives to rare earths. The leading technology in electric batteries, nickel metal hydride,


transition to Breeding 4 {#Sec2}
==========================================================================

The concept of causal loci and the curse of dimensionality {#Sec3}
----------------------------------------------------------

The concept of loci controlling agronomic traits has been at the core of breeders' ability to describe and exploit genetic variability. As breeding science progressed, a better understanding of causal loci has increased breeders' control over the genetics of complex traits. In Breeding 1, the basis for variability at agronomic traits was unknown, making mass selection the only viable breeding scheme. In Breeding 2, the concept of a causal locus ("Mendelian factor") allowed breeders to exploit family relationships and more accurately estimate breeding values (Fisher [@CR24]; Wright [@CR84]). Nevertheless, this concept was still a theoretical construct and assumed an infinitesimal model for complex traits: it could not account for deviations from expected genetic relationshipsor metabolic activity) can be used to provide many phenotypes per genotype (e.g., using expression data on every gene in a genotype, as in Kremling et al. [@CR45]). Alternatively, the number of loci assayed can be decreased by focusing only on single genes or regions of the genome (e.g., focusing on polymorphisms in promoter regions and the UTR, as in Washburn et al. [@CR83]). Relationships between polymorphisms and phenotypes can be depicted more accurately with genetically simpler traits than with the agronomic traits used in Breeding 3. In Breeding 4, using simpler endophenotypes or component traits as phenotypes should therefore reduce the required model complexity. Biologically meaningful models are critical, because Breeding 4 will require a significantly better understanding of the relationship between genotypes and phenotypes (the genotype--phenotype


ORANGE PARK, Fla. – A Clay County sheriff's deputy was on duty when he was critically injured in a crash late Sunday morning in Orange Park, authorities said.

It happened about 11 a.m. while Traffic Deputy Ben Zirbel, a 12-year veteran of the Clay County Sheriff's Office, was riding his agency-issued motorcycle on Blanding Boulevard at Camp Francis Johnson Road, just south of Kingsley Avenue.

According to the Florida Highway Patrol, the traffic deputy was traveling south on his Clay County Sheriff's Office motorcycle when the driver of a pickup truck on northbound Blanding Boulevard attempted to turn left onto Camp Francis Johnson Road.

FHP Sgt. Dylan Bryan said the driver of the Dodge Dakota pickup, which was towing a lawn trailer, failed to yield the right of way to theSubscribe to Our Blog

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As a software development company, we know the pain of managing projects via emails. We wanted a software/tool – to manage projects more efficiently, to have quick communications and to become more productive


wear all day, every day.
All U.S. orders ship for $3.60 flat rate shipping. Priority shipping is available, and international customers are welcome. Please send me any questions you may have. I look forward to doing business with you.problem is economic.

She thought that the Polish Army would have to be mobilized to harvest crops, and that everyone would simply have to buckle down and work.

Among the people I talked to, even those who were no fans of the East German system couldn't quite grasp it when I suggested that the basic issue in Poland wasn't economic at all, but rather individual human dignity. Nor could they understand why the West was helping Poland out with so many new loans.

Implicitly they are aware that their country has the highest standard of living in the entire Soviet bloc. They have no desire to jeopardize their position by some foolhardy imitation of the Poles. At the same time they dismiss the likelihood of any Warsaw Pact invasion of Poland.


The Soviet Union and east Germany have shown too much "solidarity" with the Poles and helped them out too much for that, they thought.

The West German youth demonstrations of this year, some of them violent, elicit no more comprehension from the man in the street here than do the Polish strikes. One grandmother who had just visited West Berlin to get a kitchen slicer for her husband's birthday (as a pensioner she can travel to the West, and relatives there solved her lack of Western currency by purchasing the slicer for her) thought the West Berlin squatters and demonstrators were "perverse." she added, "When you have too much [prosperity] it's not good."

The engineer agreed, and feared that West Germany might "destroy itself through too much democracy."

In similar veinThis invention relates to a pocket-sized, portable, personal terminal unit which may be used in a system for handling a wide variety of financial, shopping, and other transactions.
In recent years there has been a trend to automate financial, shopping, and bill-paying transactions and to eliminate bank checks by providing automatic cash dispensing terminals and by providing "debit" credit cards, for example.
One of the problems associated with the use of financial or transaction terminals is that they tend to "frighten" or overwhelm users who are not too sophisticated in the use of such terminals. Another problem is that users are required to operate several different terminals or are required to carry several credit or debit cards to carry on their transactions. For example, the following is a general list


travel infrastructure projects in the region, as well as providing outstanding and affordable travel services."

The news was not as well recieved by campaigners for NOR4NOR, which took a stand outside Norwich train station.

A spokesman for the group, which campaigns for a publicly-owned system, said: "This is another huge blow to rail passengers, making British rail fares the highest in Europe and keeping fares ahead of wage levels.At a time when the climate emergency means we should be encouraging rail travel, the privateers will be able to deter thousands of passengers from using public transport."

If you value what this story gives you, please consider supporting the Eastern Daily Press. Click the link in the yellow box below for details.

This newspaper has been a central part of community life forcoker drums where the hot material is held for an extended period of time at desired pressure, until coking reaction completes. Vapors from the drums are fed to a fractionator where gas, naphtha, and gas oils are separated out. The heavier hydrocarbons obtained in the fractionator are recycled through the furnace as per the requirement. After the coke reaches a predetermined level in one drum, the feed flow is diverted to another coker drum to maintain continuous operation. The coked drum (i.e. coker drum having coke upto the predetermined level) is steamed to strip out entrapped hydrocarbons, cooled by water injection and decoked by mechanical or hydraulic methods.
Recently in prior art, a number of inventions have come up in the area of delayed coking process, that suggest addition


summer, and give Murphy the ball and he can make something from nothing. With Stringer and Warwick running the show and the pace of Hurley and Howlett out wide it should hopefully be a very good game from a Munster point of view.

I have been told Nick Williams will be one to watch this evening, he has apparently lost a lot of weight, so the folks on the terraces won't be mixing him up with Tony Buckley any more but he is Incredibly powerful as well.

I rate Niva Ta'auso, but he isn't as much of a threat when partnered with Nathan, I'm happy that Mathews isn't playing as he is a far better player.

Indeed a great game. It's incredible that Barry Murphy, Denis Hurley, Niall Ronan, Donnacha Ryanthey are nearly identical (see [Figure S2](#notes-1){ref-type="notes"}).

Long-range electrostatics were calculated using the k-Gaussian Split Ewald method on a 64×64×64 grid. The cutoff was determined independently for each simulation, but typically was around 13 Å. For simulations investigating the motion of a substrate helix located at the lateral gate, i.e., those illustrated in Figure [2](#fig2){ref-type="fig"}, an elevated temperature of 353 K was employed to enhance the likelihood of observing helix movement on the μs time scale; all other simulations on Anton were carried out at 323 K. Temperatures of 353--490 K have previously been validated for peptide--membrane partitioning studies and were found to not significantly affect the systems' thermodynamic properties.^[@ref25]^ The total time for all Anton simulations is ∼30 μs.

PMF Calculations {#sec2.3}
----------------

The PMFs shown in Figure [3](#fig3){ref-type="fig"}B were calculated


partitioning process, the observed behavior is nonetheless undersampled. To quantify this behavior, the PMF as a function of substrate helix distance from the channel's center was determined for the SA, polyLeu, and polyGln helices. Each PMF was calculated using approximately 350 ns of US simulations at 323 K. Because lipid diffusion occurs on a time scale of tens of nanoseconds,^[@ref48]^ in order to fully relax the membrane surrounding the helix, initial states for every fourth window (i.e., every 4 Å) were generated from 70-ns equilibrium simulations run on Anton.

![Potential of mean force for helix exit from SecY into the membrane. (A) SecY is shown from the cytoplasmic side in gray and orange with the membrane in blue. A substrate helix is shown in red at different positions alongkinetic process (between bold parentheses) responsible for the apparent thermodynamic partition coefficient. The commitment time is defined as the length of time the states in parentheses persist before an irreversible course into the membrane or the lumen is taken.](ja-2012-10777k_0004){#fig4}

Estimates for the parameters in the model were extracted from previous experiments or from simulations (see [Methods](#sec2){ref-type="other"}), and their effect on insertion probability was determined. Decreasing the rate of translation, which ranges from 0.5 to 20 residue/s,^[@ref7],[@ref30],[@ref31]^ causes the TM segment to be retained near the channel longer and, thus, decreases the probability of insertion on the same time scale (see [Figure S11A](#notes-1){ref-type="notes"}). However, if the rate of translation also alters the rate of translocation, such an effect may be muted; indeed, experimentally, when slowing translation from 0.5 to 0.25


(ISI) and final state interaction (FSI) effects on the nucleon-nucleon collisions when the transition occurs near the threshold [@Haidenbauer:1991kt; @Haidenbauer:1992wp; @Kohno:1986mg; @Baru:2002rs; @Hanhart:2003pg], where the ISI and FSI effects are thought to be governed by the nonperturbative QCD effects and are rather complicated. The authors of Ref. [@Hanhart:1998rn] studied the ISI effect on meson production in $NN$ collisions, where the ISI leads to a reduction of the total cross section of the order of $|\lambda_L|^2=\eta_L(p)\cos^2(\delta_L(p))+\frac{1}{4}[1-\eta_L(p)]^2$, which relates to the phase shift $\delta_L(p)$ and inelasticity $\eta_L(p)$ of $NN$ scattering. With increasing the energy, the dependence of $|\lambda_L|^2$ on energy becomes smaller. In addition, by studying the reaction $NN\to NN\eta$, the authors in Ref. [@Baru:2002rs] claimed that the FSI effect is not universal and depends on the concrete meson production010001 (2012). C. Chen, X. -L. Chen, X. Liu, W. -Z. Deng and S. -L. Zhu, Phys. Rev. D [**75**]{}, 094017 (2007) \[arXiv:0704.0075 \[hep-ph\]\]. H. -Y. Cheng and C. -K. Chua, Phys. Rev. D [**75**]{}, 014006 (2007) \[hep-ph/0610283\]. X. -H. Zhong and Q. Zhao, Phys. Rev. D [**77**]{}, 074008 (2008) \[arXiv:0711.4645 \[hep-ph\]\]. M. F. M. Lutz [*et al.*]{} \[PANDA Collaboration\], arXiv:0903.3905 \[hep-ex\]. S. Okubo, Phys. Lett.  [**5**]{}, 165 (1963). G. Zweig, Developments in the Quark Theory of Hadrons, Volume 1. Edited by D. Lichtenberg and S. Rosen. pp. 22-101 J. Iizuka, Prog. Theor. Phys. Suppl.  [**37**]{}, 21 (1966). D. Griffiths, Weinheim, Germany: Wiley-VCH (2008) 454 p, chapter 5.4.1. B. S. Zou and F. Hussain, Phys. Rev. C [**67**]{}, 015204 (2003) \[hep-ph/0210164\]. J. -J. Wu, Z. Ouyang and B. S. Zou, Phys. Rev. C [**80**]{}, 045211 (2009) \[arXiv:0902.2295 \[hep-ph\]\]. Z. Ouyang, J. -J. Xie, B. -S. Zou and H. -S. Xu, Int. J. Mod. Phys. E [**18**]{}, 281 (2009) \[arXiv:0902.1818 \[nucl-th\]\]. R. Machleidt, K. Holinde and C. Elster, Phys. Rept.  [**149**]{}, 1 (1987). K. Tsushima, A. Sibirtsev, A. W. Thomas and G.Q. Li, Phys. Rev. C [**59**]{}, 369 (1999) \[Erratum-ibid. C [**61**]{}, 029903 (2000)\] \[nucl-th/9801063\]. S. -Z. Huang,


Q:

WPF slider's Tooltip StringFormat doesn't work

I have a slider and I want to display his value on the ToolTip.
As slider's Value property is a double, ToolTip display like "12.12548565". I just want to display a rounded value ("12")
I've tried :
<Slider x:Name="sldAnalogSetPoint"
        Maximum="100"
        ValueChanged="sldAnalogSetPoint_ValueChanged"
        Cursor="Arrow"
        ToolTip="{Binding Value, ElementName=sldAnalogSetPoint, StringFormat=/{0:D/}}"/>

what's wrong ?

A:

Use  IsSnapToTickEnabled and TickFrequency properties fo slider:
How do you make a WPF slider snap only to discrete integer positions?
ToolTip:
ToolTip="{Binding Value, ElementName=sldAnalogSetPoint}"

<Slider ... IsSnapToTickEnabled="True" TickFrequency="1"/>

You can also use Converter(https://msdn.microsoft.com/en-us/library/system.windows.data.ivalueconverter(v=vs.110).aspx) for your binding. But that will be bad solution.

opportunities and challenges for functional studies[@b10][@b11][@b12]. However, only a small number of phosphosites have characterized functions, and the functional roles of many phosphosites remain unclear. Landry *et al.* studied the phosphoproteomes from an evolutionary perspective and suggested that a large percentage of phosphosites were non-functional (the estimated proportion was 65%)[@b13][@b14]. It was proposed that the non-functional phosphosites may result from the off-target recognition of kinases[@b13]. Phosphosites with important functions are of great value for both experimental and computational biology. However, conventional predictors concentrate on predicting whether a site is phosphorylated, and few make any prediction as to whether the site itself is functional[@b15][@b16][@b17]. Furthermore, with the high-throughput rate of mass spectrometric analyses of protein phosphorylation, there is likely a high proportion of non-functional sites and issues with localization


identification was not provided. The current study focused on evaluating the intrinsic characteristics of functional phosphosites and predicting whether a phosphosite is likely to be functional using multiple integrated characteristics. Features including conservation, kinase association and structure information were explored and compared in both known functional and background phosphosite datasets. The two datasets were classified by several trained classifiers based on feature integration. We also used the model to screen all human phosphosites collected from a variety of databases to provide the most likely candidates for further study.

Results
=======

Training set
------------

The construction of training datasets is critical for machine learning analysis. In this study, known functional human phosphosites from the PhosphoSitePlus database (file name: Regulatory_sites, version: 060415) were used as the positive dataset[@b25]. For the negative data, we first filteredof kinases may occur more frequently, which could result in a large number of non-functional phosphosites. In addition to the disorder state, the underlying secondary structure may also have a great impact on the function of a phosphosite[@b38][@b39]. In this study, for each phosphosite, we calculated the disorder score and the types of secondary structures, i.e., beta sheet, helix and coil.

To evaluate the predictive ability of each feature, we compared their distributions in the positive and negative datasets. In both datasets, the majority of phosphosites are located in the disordered region ([Fig. 2A](#f2){ref-type="fig"}). However, more sites in the positive dataset have relatively lower disorder scores, indicating that more positive sites are located in ordered regions compared to negative sites. The score distributions in the two datasets are significantly


different (p-value \< 2.2e-16, Wilcoxon rank sum test). This result is consistent with our expectation that background phosphosites occur more frequently in disordered regions, where more off-target events could arise.

We compared the distribution of secondary structures in the two datasets and found that they were also significantly different (p-value = 2.29e-6, Chi-squared test). As shown in [Fig. 2B](#f2){ref-type="fig"}, most of the phosphosites in both datasets prefer to locate in coils, but the proportion of sites in coil structures in the negative dataset is significantly higher than that in the positive dataset, which is in agreement with the distribution of disorder scores.

Association with kinase
-----------------------

Due to the off-target activity of kinases, we hypothesized that randomly phosphorylated sites tended to have weaker associations with kinases[@b13]. If a phosphosite is functional, it is more likely tofeature selection procedure. For each round, we generated a randomly chosen balanced dataset and selected an optimal subset from the features investigated above using the attribute selection tools in Weka (see Methods)[@b41]. Among the features, some were very robust (e.g., kinase score was selected as the best feature in all 50 rounds). We counted the frequency of each feature as it appeared in the selected feature subset and chose the top 5 high-ranked features. Consequently, the final robust feature subset included the kinase score, sequence conservation in mammals and eukaryotes, disorder score, and beta-sheet state.

We trained four different types of machine learning models, including Bayesnet, Logistic regression, Random Forest and Multilayer Perceptron. We split the full datasets into 90% for the training set and 10% for the independent


positive dataset (and predicted positive dataset) was significantly lower than that in the whole phosphosite dataset, which provided statistical evidence for the rationality and effectiveness of our method. However, there are still false-negative phosphosites that may affect the performance of our prediction. A better solution would be to find phosphosites with high-frequency polymorphisms in the human population, but these are limited due to the lack of frequency information of current SNP data. Further extension of SNP frequency information may improve the prediction ability.

Methods
=======

Data collection
---------------

We downloaded all human phosphosites and regulatory phosphosites from the PhosphoSitePlus database (version: 060415)[@b25]. Additionally, phosphosites from dbPTM, which integrated Phospho.ELM (release 9.0), UniProtKB (release 2015-08), HPRD (release 9.0) and SysPTM (release 2.0), were also collected to build a comprehensive human phosphosite database[@b42][@b43][@b45][@b46][@b47]. The PhosphositePlusChávez and a sharp blow to his plan of extending regional influence. In addition, the coup conformed with Chávez's ideology, in which the Latin American right wing -- or what he calls the "squalid oligarchy" of traditional economic and political elites -- would not tolerate leftist governments. Lastly, in an ironic twist, it enabled Chávez, who, in 1992, attempted a military coup against an elected Venezuelan government, to claim the moral high ground by criticizing the Honduran military's actions.

From the outset, the Obama administration showed a desire to condemn such a flagrant unconstitutional act. President Barack Obama called Zelaya's ouster "not legal" and said that it set a "terrible precedent." Such statements were intended to repair the damage to U.S. credibility in Latin America, which was hurt most


that pneumonia can be prevented by vaccination, rather than by an umbrella, or refraining from kissing girls.

Editor-in-Chief's challenge {#Sec6}
===========================

Rather than waiting for current knowledge of vaccine efficacy to filter down to popular culture, perhaps the next step in raising awareness about pneumonia is to take our knowledge of the disease and pen a song about pneumonia prevention---who knows, it might just be a hit!

Thus, the *Pneumonia* journal has a holiday challenge for you: to compose lyrics for a song that highlights vaccination as a means of preventing pneumonia. The most fitting submissions will be published as responses to this commentary.

We thank Anya Luscombe (University College Roosevelt) for editing the final text.

All references to songs are listed by year of release. If the song is published as part of
Microsoft Visual Studio Solution File, Format Version 12.00
# Visual Studio 11 Express for Windows 8
Project("{8BC9CEB8-8B4A-11D0-8D11-00A0C91BC942}") = "ShapesPuzzle", "ShapesPuzzle.vcxproj", "{3A7DE574-5AEA-4402-A772-9F36F7CF3663}"
EndProject
Global
	GlobalSection(SolutionConfigurationPlatforms) = preSolution
		Debug|Win32 = Debug|Win32
		Debug|ARM = Debug|ARM
		Debug|x64 = Debug|x64
		Release|ARM = Release|ARM
		Release|Win32 = Release|Win32
		Release|x64 = Release|x64
	EndGlobalSection
	GlobalSection(ProjectConfigurationPlatforms) = postSolution
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|ARM.ActiveCfg = Debug|ARM
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|ARM.Build.0 = Debug|ARM
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|ARM.Deploy.0 = Debug|ARM
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|Win32.ActiveCfg = Debug|Win32
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|Win32.Build.0 = Debug|Win32
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|Win32.Deploy.0 = Debug|Win32
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|x64.ActiveCfg = Debug|x64
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|x64.Build.0 = Debug|x64
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Debug|x64.Deploy.0 = Debug|x64
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|ARM.ActiveCfg = Release|ARM
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|ARM.Build.0 = Release|ARM
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|ARM.Deploy.0 = Release|ARM
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|Win32.ActiveCfg = Release|Win32
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|Win32.Build.0 = Release|Win32
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|Win32.Deploy.0 = Release|Win32
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|x64.ActiveCfg = Release|x64
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|x64.Build.0 = Release|x64
		{3A7DE574-5AEA-4402-A772-9F36F7CF3663}.Release|x64.Deploy.0 = Release|x64
	EndGlobalSection
	GlobalSection(SolutionProperties) = preSolution
		HideSolutionNode = FALSE
	EndGlobalSection
EndGlobal