including herself.                         Law  enforcement  conduct  runs afoul  of  the Due             Process  Clause  of  the Fifth  Amendment  when  it violates             "fundamental fairness,  shocking to  the universal  sense of             justice."   United  States  v. Russell,  411  U.S. 423,  432                           Section  3C1.1  requires  a  sentencing  court  to             enhance a defendant's sentence level by two points "[i]f the             defendant willfully  obstructed or impeded,  or attempted to             obstruct or impede, the administration of justice during the


The umpires found pine tar on Peralta's glove. He was ejected from the game and expects a suspension of up to 10 days from Major League Baseball. The league office said it was investigating the incident and that no decision would be announced Wednesday.

Maddon was furious after the game, calling Johnson's actions "cowardly," "bush" and "bogus." Johnson knew about the pine tar because he had inside information on Peralta, who pitched for the Nationals in 2010.

Johnson responded to Maddon before Wednesday's game, and Maddon then responded to Johnson. Some of the words used would not appear on most Christmas cards.

Johnson: "Any time there's a rule violation, as far as I'm concerned, it's just a rule violation. My only comment to him is read the rulebook. It's simple."

Maddon: "Ilooked him up on the Internet and found out he is a tweeter, so he can get to more people than me. But it was interesting reading. But you can tell him I have a doctorate of letters, too. Mine's from Loyola in Humanities, and I'm proud of that, too."

Maddon was equally dripping in sarcasm, calling Johnson's glove-search move "an attempt to indicate a higher form of baseball intellect."

It was pointed out to Maddon that his player broke a rule and got caught, yet he chose to deflect responsibility toward Johnson.

"To utilize information based on the fact that the guy played here?" Maddon said. "If you want to talk about -- I don't know if that's a form of cheating or what -- but that's really kind of


underhanded, I believe, to use that kind of information."

Maddon said pine tar use is "common knowledge in the industry" by "every major league baseball team." He said glove manufacturers "were probably inundated with new orders last night and this morning by various agents throughout baseball."

Umpires inspect the glove of Tampa Bay Rays pitcher Joel Peralta. Jonathan Newton/The Washington Post/Getty Images

If it's that widespread, he was asked, shouldn't something be done about it?

"It is done about it," Maddon said. "In baseball, players throughout history have always had this amazing ability and way to police themselves. There's a policing themselves component of this game that we should stay away from -- let the players take care of things. It's happened for a long time."

And what have the players concluded aboutRelationship of symptoms in faecal incontinence to specific sphincter abnormalities.
We aimed to determine if the type of clinical presentation in patients with faecal incontinence correlated with the underlying sphincter pathology. One hundred fifty one consecutive patients (129 female) with faecal incontinence were classified as having either passive (faecal incontinence without the patient's knowledge) or urge incontinence (incontinence occurring with the patient's awareness, against their will because of lack of voluntary control), and were investigated by routine anorectal physiological testing and anal endosonography. Sixty six patients had passive incontinence (PI) only, 42 patients had urge incontinence (UI) only, 38 patients had combined passive and urge incontinence, and 5 patients had soiling after defaecation only. Patients with PI alone (n = 66) were significantly older than those with UI alone


-3
40324397
Calculate 4543101 divided by 27.
168263
What is 515484 divided by 515484?
1
16 divided by -34547677
-16/34547677
What is 893788 divided by -15?
-893788/15
Divide -6480050332 by 4.
-1620012583
What is -7 divided by -14346213?
1/2049459
-1117366 divided by -2
558683
93193470 divided by 24081
3870
85232 divided by 1560
10654/195
Calculate 4744 divided by 1702.
2372/851
Divide 653 by -12017.
-653/12017
What is 1075 divided by -34881?
-1075/34881
-65 d
20 B.R. 155 (1982)
In re Mary Frances FRENCH, Debtor.
Mary Frances FRENCH, Plaintiff,
v.
UNITED STATES SOCIAL SECURITY ADMINISTRATION and Robert K. Morrow, Trustee, Defendants.
Bankruptcy No. 381-01762, Adv. No. 81-0547.
United States Bankruptcy Court, D. Oregon.
May 20, 1982.
*156 Amy Levinson, Portland, Or., for plaintiff.
William B. Borgeson, Portland, Or., for defendant.
OPINION GRANTING SUMMARY JUDGMENT TO PLAINTIFF, ENJOINING UNITED STATES SOCIAL SECURITY ADMINISTRATION
DONAL D. SULLIVAN, Bankruptcy Judge.
The debtor, a retired state employee, filed a complaint to enjoin the United States Social Security Administration (SSA) from offsetting a prebankruptcy overpayment of Social Security benefits against postbankruptcy benefits. Plaintiff also sought to hold the government in contempt and to recover attorneys' fees and other costs. The government, without answering, filed a motion for summary judgment which was supported by a memorandum and affidavit.
Except for benefits paid


the new Bankruptcy Code makes specific and limited provision for the nondischargeability of certain debts owing to the government coupled with waiver of sovereign immunity and a general grant of original jurisdiction is strong evidence that Congress did not intend the government's ability to recoup Social Security benefits under 42 U.S.C. § 404 to escape § 727(b) and § 524 of the Code. § 523(a)(1), (7) and (8) of the Code makes nondischargeable certain nonstale taxes, fines and penalties, and certain student loans. § 106(c) of the Code waives sovereign immunity and 28 U.S.C. § 1471(b) grants general jurisdiction to the Bankruptcy Court and to the District Court. As further evidence of the Bankruptcy Code's evident purpose to deal with dischargeability of government claims to the exclusion ofspecific prior written permission.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS
// "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT
// LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR
// A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT
// OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
// SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT
// LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE,
// DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY
// THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT
// (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
// OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.

/*
Package proto converts data structures to and from the


which need to be watched) like 'api/**/*.js` there's hardly any CPU usage.
What am I doing wrong?

A:

gulp v3's watch had known CPU usage issues for almost 5 years.  This is because gulp uses polling (fs.watchFile) to detect changes.

This has allegedly been fixed in gulp 4.0 (released Dec 2018), but there are reports of similar issues.
For versions < 4, the workaround recommendation is to increase the polling interval.
gulp.watch('**/*.js', { interval: 2000 }, ...)

(the default is 100)
@Sven's advice is also very sound -- there's likely no reason to watch your node_modules or build folders.

A:

You are watching all .js files in all directories and subdirectories of your project. Which includes node_modules. Depending on how many dependencies you have in your project and how many dependencies those dependencies have etc. you mightQ:

How are double precision floats stored in memory?

I would like to know how double-precision numbers are organized in memory.
Say that I want to write 16.55 (0xd40308cccccccccc) to a 2-way interleaved 32-bit memory module, which one of the following would be the correct organization?
mem 0 0xD40308CC
mem 1 0xCCCCCCCC
or
mem 0 0xCCCCCCCC
mem 1 0xD40308CC
RISCV-GCC seems to produce the latter, but I'd like to read more about this, any advice is greatly appreciated!
-Edit: formatting

A:

RISC-V is little-endian (by default), the bits to the right are stored at earlier memory addresses.
You can find this information in https://content.riscv.org/wp-content/uploads/2017/05/riscv-spec-v2.2.pdf.


daily caloric intake, quality of life, and use of weight control practices. ANCOVA, with adjustment for baseline values on outcome measures, was used to assess differences between groups in primary and secondary outcomes. Statistical analyses were conducted in 2010-2011. Most participants were women (69.7%) and white (90.8%), with a mean age of 50.3 years and baseline BMI of 33.2; 88% completed post-program assessments. Mean weight loss among intervention participants was -1.4 kg (95% CI= -2.2, -0.5), compared with a mean weight gain of 0.6 kg (95% CI= -0.3, 1.4) in control participants (p<0.01). User-generated weight-loss practices from "positive deviants" could promote weight control in web-based interventions; however, further research is needed to improve program efficacy. This study is registered at ClinicalTrials.govNCT00709501.worn out. he can just use new ones. Most of all, I think he keep Mikoto, the original, around for a reason. It would surprise me the net work, LO, are just a series of test runs before Mikoto is put into action.

Quote:

Originally Posted by Marcus H.

WORST belongs to a different kind of network, with Full-Tuning as the administrator.

Nope, Full Tuning is still MIA right now. Misaka Worst is still connected to the current Misaka Net Work, just she doesn't have to take LO's order.


influenced further differentiation. The differences follow the general path of Germanic and Latinish pairs in English: we associate the Germanic one with earthier, mundane, poorer, and more agricultural topics and the Latin one with more monied, professional, erudite, educated, and aristocratic senses.
Primarily, the difference stems from the use of "collect" to round up money for the church and king: You "gather" fruit(s), lambs, tribute, flowers, ground, wind, wheat but you "collect" money, tax(es), revenue, rents. You call collect and collect individual things and people from some particular location.
Once British aristocrats started accumulating individual scientific, literary, and eccentric possessions in the 18th and 19th centuries, it was natural for them to speak of their "collections". That's the distinction Lawrence focuses on and it's the major one people make consciously.(as opposed to gathering it), there are specific criteria for examples you retain, and you organize them in some way.
LawrenceC's rainwater example is explained well.  Gathering it just aggregates it; control and direction rather than retention because it won't stay aggregated on its own.  Collecting it retains a specific sample (the water you manage to get into in the container).
For your junk example, a lot would depend on the situation.  If you have an actual junk collection (i.e., save specific kinds of items), you might go somewhere to find items to add.  In that case, you might say that you "went to collect junk", although people might be more likely to say that they "went to find junk to add to their


won't bring back our land" "I can't cheer up." "Big Zhang, you're always messing around." "Quit, or just the sight of us will give everyone headaches." "Old Zheng!" "Just because you went to DongBei University..." "That doesn't make you my boss!" "I'm not bossing you around!" "But keep acting like this, and our whole country will be conquered" "You're the conquered one!" "I'm too poor to get a girl, so just throw them pebbles for fun." "What's the matter with that?" "Brother Jin, Big Zhang's been flirting again." "Heh!" "I let you hit me without fighting back." "There's no fighting here!" "Jin..." "Big Zhang... don't come back tomorrow!" "But Master Zhang, Brother Jin was just teaching Big Zhang a lesson." "It didn't affect our work." "Okay then, all"Ayaa, you win!" "What do you want?" "Daddy's invited you all to dinner tonight!" "There are watermelons on that donkey!" "..." "Brothers, let's go!" "Hey!" "Little Luo and Lilac snuck off!" "The flowers are fresh, red and blossom on the riverside" "The swallows fly in pairs, among the willow leaves" "The swallows fly so well, and look like they're wearing yellow shoes and black clothing" "The swallow ji-ji-ji wearing clothes" "Fly and fly... fly into the sky" "The swallow ji-ji-ji wearing clothes" "Fly and fly... fly back to the nest" "Good night, swallows." "Fly and fly and fly. ji-ji-ji" "Good night swallows." "Fly fly fly." "Wearing clothes." "Fly back to their nests to feed the baby swallows." "Ji-ji-ji good night, swallows." "It's time for dinner." "Feed the baby


crossroads between Europe and Asia.

“Never before has Ukraine made so many prized archaeological exhibits available on loan,” the Allard Pierson Museum said ahead of displaying the collection in Amsterdam in 2014.

The exhibition included items originating from four museums in Crimea and one museum in Kiev, Ukraine’s capital.

In August 2014, the museum returned the artifacts it borrowed from the National Museum of History of Ukraine. However, after facing “conflicting claims” of ownership from both sides, it is still in possession of 572 disputed items.

Let our news meet your inbox. The news and stories that matters, delivered weekday mornings. This site is protected by recaptcha

A grave inventory of a Late-Scythian elite woman from the first century A.D., is displayed as part of the exhibit called The Crimea - Gold andin the sum of $8,035.23, in favor of his wife.

5
In the second action an order was entered June 24, 1941, directing petitioner to pay his wife the sum of $1,000 per month, pursuant to a judgment entered against petitioner on March 29, 1941, in favor of his wife in the sum of $15,974.20.  This judgment was affirmed by the Appellate Division of the Supreme Court of New York, Terrell v. Terrell, 264 App.Div. 720, 34 N.Y.S.2d 833, and a petition for leave to appeal therefrom was denied by the Court of Appeals of New York, 288 N.Y. 740, 42 N.Y.2d 751.  Petitioner paid to his wife, or to her attorneys for her account, $12,000 during the year 1942, and also a like sum during 1943.


PSG 2018 Honours Bursaries (Various)

PSG is a leading financial services provider in South Africa and is committed to contribute towards the growth, development and empowerment of youth in the country. Our PSG Bursary Programme aims to create a pipeline of young talent within the financial services industry.

Ambitious & looking to advance in their career within the financial services industry

Energetic with a solution oriented attitude

Good at working in a team

Able to remain calm under pressure

Resilient

Attention to detail

How to apply:

If you meet with the minimum requirements, you can apply by visiting our PSG website. Simply go to the to this link (CLICK TO OPEN) and complete the registration process. Upload your CV, academic transcripts, and a copy of your ID and submit your application to the relevant programme.of carrying up to 75,000 pounds (34,000 kilograms) of weapons — the largest payload of both guided and unguided weapons in the USAF’s inventory. Though heavily armed, the bomber can reach a top speed of Mach 1.2 and can operate at altitudes above 30,000 feet (9,100 meters),” I explained elsewhere.


recently explained that, even if a plaintiff's protected conduct is a "substantial element" in a defendant's decision to take adverse action against an employee, the employer is not liable for unlawful retaliation so long as the employer would have taken the same action "even in the absence of the protected conduct." Id.
Defendant has proffered nondiscriminatory explanations for its conduct which Plaintiff has not sufficiently rebutted. See supra at 1311-1312 (discussing Plaintiff's showing of pretext for her disparate treatment claim). Plaintiff has not presented evidence that, but for her complaints to Sheehan, Defendants would not have taken the same actions regarding her employment. See Long, 88 F.3d at 305 n. 4. Therefore, Plaintiff has failed to raise a genuine issue of material fact as to her claim of retaliation,in her job description, or are differences in judgment as to entitlement for pay increases or work priorities.
Plaintiff's evidence, even if proven, is insufficient as a matter of law to establish a claim for racially hostile work environment.[27] Therefore, summary judgment is granted as to Plaintiff's hostile work environment claim.

CONCLUSION
For the reasons stated herein, it is now
ORDERED that Defendant's Motion for Summary Judgment [Doc. # 43] is GRANTED. It is further
ORDERED that Plaintiff's Motion for Summary Judgment [Doc. # 46] is DENIED. It is further
ORDERED that Defendant's Motion to Preferentially Set Case for Trial, or in the Alternative, to Refer the Case for Trial to the United States Magistrate Judge as a Special Master Under Fed.R.Civ.P. 53(a), (b) [Doc. # 50] is DENIED AS MOOT. It is finally
ORDERED


Plaintiff has not directed the Court to any summary judgment evidence in support of this allegation. See Jones v. Sheehan, Young & Culp, P.C., 82 F.3d 1334, 1338 (5th Cir.1996) (Rule 56 "saddles the non-movant with the duty to `designate' the specific facts in the record that create genuine issues precluding summary judgment, and does not impose upon the district court a duty to survey the entire record in search of evidence to support a non-movant's opposition"); Little v. Liquid Air Corp., 37 F.3d 1069, 1075 (5th Cir.1994) (non-movant's summary judgment burden may not be satisfied by conclusory allegations, unsubstantiated assertions, metaphysical doubt as to the facts, or a scintilla of evidence).
[7]  See Williams Affidavit, at 2, 4. On a scale of 1 to 8, Plaintiff's proficiencyWhere are you from?
- Monticello, Arkansas.
- Alabama.
- I'm from Illinois.
- Kentucky.
- [Crowd] Yeah!
(upbeat music)
- [Woman] What'd you
guys bring Tic Tac Toy?
- A picture of my daughter's
birthday cake that
she wanted made for her fourth birthday.
- [Woman] Oh my gosh.
She wanted the Tic Tac
Toy family on her cake.
- Well, it's 3 o'clock.
It was supposed to be from 11 to one but
we didn't want to leave
anybody in the line
without getting a chance to come say hi,
so we hung for four hours.
Poor Maya I think is done,
I think she stopped smiling at the end and
she was just ready to take a nap, but
we made it and it was so
nice to see all the fans,
to see all our friends, and
the distances people came to
meet us is just mind blowing.
So thank you if you
came


rare nowadays. We see all these high school movies every now and then, but no matter how much of a boy/girl-next-door character filmmakers think they’ve got, none come close to Finicky. She’s a goofy nerd who’s into manga and books, dresses like a teen, and doesn’t go to school looking like she just came out of a photoshoot. In some scenes, she looks like she’d just gotten out of bed, and quite frankly, as a college student myself, that is how most of us look. There are things far more important to do and think about during the day than our appearances. Woodley paints a picture of a humble highschooler trying to get through school and make the tough decision of moving on without her family, and howget that from The Spectacular Now.

The script is okay overall. It started out quite cliché, like the beginning of the movie itself, but then turned into something so much more. It had some predictable dialogue in there but eventually took a turn for the unpredictable, for the original. It seemed like it lacked the potential to be remedied initially, but managed to pick itself up from its shaky start to become something to hold on to.

There was one thing that irked me. The drinking. There was so much of it. Bottles here, bottles there, bottles everywhere! I’m aware of the purpose behind it — and you will too when you watch it — but the filmmakers overdid it. Every scene had that stupid cup in it. It was


with 60 FPS if your computer can handle it.- If you have an Invidia graphics card, you can use Nvidia Shadowplay. Go to Nvidia geforce experience to find out more. - First of all you have to get rid of the hud which appears when you are in game. Wahlamt has a good guide of getting this done.- Play the replay and hit the button you assigned to capture the footage in Fraps (F9 by default). Hit the button again to stop recording. Your .avi files will be stored on your HDD.

GraphicsIn game settings:You want to have the highest possible graphic setting as possible to make the quality of the video as best as possible.- You want to put everything on the sliders as close to the maxrunning 256x256 terrain textures. You need to use one of the direct modes for it to honor settings over 256x256.

Graphic Card Setting

yzmxer608 wrote:A few notes/explanation:-Reasoning for the 8xS antialiasing mode: It is combined 1x2 SS + 4x MS. SS stands for supersampling, and MS stands for multisampling, a quick explanation of each:

Tweak Guides wrote:The most common form of AA a few years ago was Supersampling which is a brute force method that pretty much just increases the resolution of the entire image within the graphics card to remove jaggedness, then rescales it back down to display at your chosen resolution. This method reduces performance a great deal, but works with almost any game.

Multisampling (MSAA) is a newer form of AA which came about through incorporating optimizations into graphics


up, then I use the Wes Williams inspired method by filling the intro with some scenery footage of the track or objects. The rest of the editing is usually done by finding footage which look to suit the music as good as possible, before I end it with a shot which I think would look great as an ending.

Whenever I am done with the editing, I try to wait a few days before I try to do my second check. I like to have my edits as much synchronized as possible since my monitor is not the best out there. So I check it by going over the whole edit in 0.50 speed and 0.30 speed to make sure each shot is matching the beat as good astype of guidelines. When DJD, and myself came up with the original keycam footage it was different, and kind of choppy but it got the job done fairly well.

The problem is when people start making their edits in this community, and it's not as good, or as fine tuned as others it instantly get a crapped on, and people start telling others how to do it a certain way. My best advice is be yourself, be different, learn as you go and find the way that works best for you. I have a 4 year degree in Digital Media/film but when I did MXS edits is how I learned my style. Not from something someone told me how I should be doing it!

Either way it appears video creation


last year, but haven’t actually practiced together yet.

Maybe you have a dozen half-written songs sitting on a hard drive somewhere. Maybe you have a gym membership that you pay for but never use (thanks, Planet Fatness).

Maybe you’ve been “meaning to” transition your little home recording studio into a full-time endeavor.

Basically, every single unfulfilled New Year’s resolution you ever made would fall under this category.

If this sounds like you in any way, then congratulations. You’re the victim of a phenomenon called The Law of Diminishing Intent.

“The longer you wait to do something, the greater the odds that you will never actually do it.”

Don’t just let your eyes glaze over that law. Go back and read it again, then let it sink in for a second…

This is something that hastrigger.

Procrastination leads to a long list of “I should” or “I need to” or “I wish I” instead of “I’ve done.”

Procrastination leads to stagnation.

Stagnation leads to complacency.

Complacency leads to mediocrity (and type 2 diabetes).

Mediocrity leads to unfulfillment.

And unfulfillment, frankly, leads to a shit life.

Who knew one law about procrastination could be such a Debbie Downer?

How To Stop Procrastinating. Now.

Yeah, I Get It. Life Is Hard. WTF Am I Supposed To Do About It? Let’s talk about how to stop procrastinating, and what you can do to avoid becoming a victim of The Law of Diminishing Intent. Here are 2 simple rules to help:

1. The 48 Hour Rule

You essentially have 48 hours to act on a new goal before it starts to wither and die. This goes for pretty


Enter I’m working with Chicago Loot Drop to make comfort kits for the kids at University Of Chicago Comer Children’s Hospital. Each kit contains games, comic books, puzzles, coloring books, LEGOs, and more. On March 19th, I want to make 5 kits and need your help raising the funds to cover them. They are $20 each so I need help raising $100.

Share! The address in your browser’s address bar is your personal donation page link. Use it in the following social media posts and emails to share your donation page.

Social Media

Use these following social media posts to tell everyone about your donation page. Feel free to make any changes you like or to write your own.

Donate $20 to cover one of the Comfort Kits I’m making w/@chicagolootdrop for== UrlSchemeType.LocalRquest)));
        }

        public static bool IsUrlRegisteredExternalRequestScheme(this List<UrlScheme> urlSchemes, string url)
        {
            if (urlSchemes == null ||
                 !urlSchemes.Any() ||
                 string.IsNullOrWhiteSpace(url))
                return false;

            return urlSchemes.Any((x => x.IsUrlOfSameScheme(url) && (x.UrlSchemeType == UrlSchemeType.LocalRquest)));
        }


Studies on phospholipase A in Trimeresurus flaoviridis venom. III. Purification and some properties of phospholipase A inhibitor in Habu serum.
Phospholipase A [EC 3.1.1.4] inhibitor was purified from Habu (Trimeresurus flavivurudls) serum by gel filtration on Sephadex G-200, chromatography on DE-23 cellulose and affinity chromatography on a Sepharose 4B-phospholipase A column. By these procedures, a 31-fold increase in specific activity was attained with a yield of 15%. The purified material was homogeneous as judged by cellulose acetate and polyacrylamide gel electrophoresis. It had an apparent molecular weight of 100,000 as measured by gel filtration on Sephadex G-200. The purified inhibitor was stable for 20 min at 80 degrees and was unstable below pH 6. It migrated before albumin in cellulose acetate electrophoresis and did not form any precipitin lineof my dress. I used to go to work with my dress or blouse half zipped knowing that I'd just ask my co-worker to help when I get to my desk - those days are gone! This is a must-have, I bought some for a few of my girlfriends and they're obsessed too.

Christine C.

The Best Friend is a life saver and I no longer have trouble zipping up my dresses! It’s super chic, sturdy and definitely a wardrobe staple. I love it and it’s been my go to gift to buy for friends. This product is a must-have!

Jill S.

I’m obsessed with this product! Hands down the best purchase I made this year. Each morning I need to have my boyfriend help zip the back of my dress but


These are friends that I have that I may not really talk to much any more, but still a friend nonetheless. Generally, however, these are also people that have absolutely no affiliation or association with the events that drove me to leave that island in the first place.

I don’t know if I’m making a lot of sense, but it’s my blog so I don’t really have to make sense anyway. Just go back a few posts and read “Brainstream”. That didn’t make sense at all.

A time came in my life when I grew the psychological and emotional strength and willpower to turn away the temptation to build bridges to the past. Along with this came the strength to let go of those that I feel have, for lacksnd_virmidi_free(struct snd_rawmidi *rmidi)
{
	struct snd_virmidi_dev *rdev = rmidi->private_data;
	kfree(rdev);
}

/*
 * create a new device
 *
 */
/* exported */
int snd_virmidi_new(struct snd_card *card, int device, struct snd_rawmidi **rrmidi)
{
	struct snd_rawmidi *rmidi;
	struct snd_virmidi_dev *rdev;
	int err;

	*rrmidi = NULL;
	if ((err = snd_rawmidi_new(card, "VirMidi", device,
				   16,	/* may be configurable */
				   16,	/* may be configurable */
				   &rmidi)) < 0)
		return err;
	strcpy(rmidi->name, rmidi->id);
	rdev = kzalloc(sizeof(*rdev), GFP_KERNEL);
	if (rdev == NULL) {
		snd_device_free(card, rmidi);
		return -ENOMEM;
	}
	rdev->card = card;
	rdev->rmidi = rmidi;
	rdev->device = device;
	rdev->client = -1;
	init_rwsem(&rdev->filelist_sem);
	rwlock_init(&rdev->filelist_lock);
	INIT_LIST_HEAD(&rdev->filelist);
	rdev->seq_mode = SNDRV_VIRMIDI_SEQ_DISPATCH;
	rmidi->private_data = rdev;
	rmidi->private_free = snd_virmidi_free;
	rmidi->ops = &snd_virmidi_global_ops;
	snd_rawmidi_set_ops(rmidi, SNDRV_RAWMIDI_STREAM_INPUT, &snd_virmidi_input_ops);
	snd_rawmidi_set_ops(rmidi, SNDRV_RAWMIDI_STREAM_OUTPUT, &snd_virmidi_output_ops);
	rmidi->info_flags = SNDRV_RAWMIDI_INFO_INPUT |
			    SNDRV_RAWMIDI_INFO_OUTPUT |
			    SNDRV_RAWMIDI_INFO_DUPLEX;
	*rrmidi = rmidi;
	return 0;
}
EXPORT_SYMBOL(snd_virmidi_new);

/*
 *  ENTRY functions
 */

static int __init alsa_virmidi_init(void)
{
	return 0;
}

static void __exit alsa_virmidi_exit(void)
{
}

module_init(alsa_virmidi_init)
module_exit(alsa_virmidi_exit)


example, the user may pass an empty string or very long string to me, so I need to avoid that as well, so my code will become like this :
/**
 * Say hello to someone.
 *
 * @param string $aName
 **/

function sayHello($yourName){

    if (!is_string($yourName)) {
        throw new ArgumentException("Type not correct.");
    }
    if(strlen($yourName)) == 0 || strlen($yourName)) > 100){
        throw new ArgumentException("argument length is invalid.");
    }

    echo($yourName);
}

ok, even worst case, I have some business logic in my function, for example, my function only allow english name, so , I will have something more complex like this:
/**
 * Say hello todeep in his own 22 to the Lions' 10-metre line where he passed. This, it seemed, was going to be a romantic evening. That was the only bit of romance and in the second half Ndungane left the field injured.

He was not the only injury. Deon van Rensburg damaged a knee and was taken off on the mobile stretcher. Fred Zeilinga ran with the ball and suddenly collapsed in agony with a hamstring injury. That was early in the first half.

Jannie du Plessis was given a yellow card for late shouldering and Willem Alberts had a tried denied because he had played a man without the ball to get these.

None of that is romantic.

Before Zeilinga went off he kicked two penalty goals, one when Lionel Mapoe was penalised


for 30 min with 3-isobutyl-1-methylxanthine (0.5 mM) to prevent cAMP degradation. Cells were then treated for 30 min with SST and receptor-specific agonists in the presence of 20 μM forskolin (FSK). DMEM was used as control. Cells were scraped in 0.1 N HCl, normalized for protein amount and cAMP was determined by immunoassay using a cAMP kit following the manufacturer's instructions.

Western blot analyses for signaling
-----------------------------------

For each experiment, 10000 cells were seeded per culture flask and grown to 80% confluency. For ERK1/2 and p38, cells were treated with SST and receptor-specific agonists for 30 min and 24 h, respectively with or without 24 h serum starvation (no FBS in culture media). To determine the expression of PARP-1, p21 and p27^Kip1^, cells were treated with SST and receptor-specific agonists for 24 h with or without serum deprivation. Post-treatment, cellsat 37°C in dark. Finally, the coverslips were washed in PBS and mounted on glass slides for analysis under Leica fluorescence microscope. Adobe Photoshop was utilized for making composites.

Statistical analysis
--------------------

Results are expressed as mean ± S.D of three independent experiments. Statistical analysis was done by one- or two-way ANOVA and *post hoc* Dunnett's or Bonferroni's tests, as applicable. GraphPad Prism 4.0 (GraphPad Software, Inc., La Jolla, CA, USA) was used for performing data analysis and *p* value \< 0.05 was considered statistically significant.

Results
=======

Human SSTR2 and SSTR3 exist as constitutive heterodimer at cell surface
-----------------------------------------------------------------------

To investigate whether human SSTR2 and SSTR3 exist in a heteromeric complex, CO-IP was performed in cotransfected cells expressing SSTR2 (279 ± 28 fmol/mg protein) and SSTR3 (285 ± 31 fmol/mg protein). As illustrated in Figure [1A](#F1){ref-type="fig"} (i), SSTR2 is expressed in the SSTR3 immunoprecipitate


with SST (1 nM and 1 μM), SSTR2-specific agonist (10 nM), and SSTR3-specific agonist (50 nM) or in combination, the effective FRET efficiency was significantly decreased when compared to control (\*, p \< 0.05). Importantly, the combination of receptor-specific agonists displayed comparable FRET efficiencies with SST which activates SSTR2 and SSTR3 equally. Taken together, these results confirm that SSTR2/SSTR3 exist in a heteromeric complex, however the relative FRET efficiency was sufficient to support heterodimerization even upon receptors activation.

![**SSTR2/SSTR3 exhibit heterodimerization at cell surface A (i).** Membrane extracts prepared from cotransfected cells were immunoprecipitated with HA antibody (SSTR3) and probed for SSTR2 as described in Materials and methods. The receptor-specific band for the heteromeric complex of SSTR2/SSTR3 was detected at the expected size of \~117 kDa. **A (ii-iii).** The membranes were reprobed to

D − A and D + A correspond to donor without and with acceptor, respectively; *τ*~*avg*~ refers to average of *n* photobleaching time constants; *n* is the total number of cells analyzed; *E (%)* is mean relative FRET efficiency. Mean ± SD is representative of three independent experiments (\*, p \< 0.05).

SSTR2 and SSTR3 colocalize at the cell surface
----------------------------------------------

As previously described, rat SSTR2/SSTR3 complex dissociated upon treatment with SST leading to SSTR2 internalization whereas the endocytosis of SSTR3 was impaired \[[@B12]\]. To ascertain whether the same holds true for human SSTR2 and SSTR3, we performed immunocytochemistry in cotransfected cells. As shown in Figure [2](#F2){ref-type="fig"}, SSTR2 and SSTR3-like immunoreactivity and colocalization at the cell surface was decreased in response to SST, accompanied by a parallel increase in cytosolic expression. Most importantly, the


SSTR3 internalized as homodimer \[[@B6],[@B9]\]. Our immunocytochemistry data illustrate decreased cell surface distribution of SSTR2 and SSTR3 upon receptors activation. Strikingly, the independent activation of SSTR2 or SSTR3 resulted in a dramatic down-regulation of both receptors and decreased colocalization at plasma membrane. It is likely that the receptors internalize as heterodimers, which in part might be a plausible explanation for an increased colocalization in cytosol. These data contradict an earlier report where rat SSTR2/SSTR3 heterodimer, while promoting SSTR2 internalization, was shown to abrogate agonist-mediated endocytosis of SSTR3 \[[@B12]\]. However, a follow-up study from the same group revealed that the activation of SSTR2 in the heteromeric complex of SSTR2/μ-opioid receptor of rat origin promoted co-internalization of both receptors \[[@B37]\]. Accordingly, our results for human SSTR2/SSTR3 reinforce the concept thatpolymerase; Pb-FRET: Photobleaching-fluorescence resonance energy transfer; SST: Somatostatin; SSTR: Somatostatin receptor; TUNEL: Terminal deoxynucleotidyl transferase dUTP nick end labeling.

Competing interests
===================

The authors declare that they have no competing interests.

Authors' contributions
======================

UK designed the study. SAW performed the experiments and data analysis. UK and SAW wrote the manuscript. Both authors read and approved the final version of the manuscript.

Acknowledgments
===============

Authors are thankful to Xiaofan Qiu for technical assistance. This work was supported by Canadian Institutes of Health Research (MOP 10268) and Canadian Breast Cancer Foundation BC/Yukon. UK is a Senior Scholar of Michael Smith Foundation for Health Research.


a readiness to fight.4

Artist, writer and publisher Paul Chan nodded at white supremacy’s bent for self-aggrandizement in his kinetic sculptural installation Madonna with Childs (2016), despite his markedly brief response to the question of how his installation disrupts white behavior: I’m not aware that it does. But I did edit and publish this. “This” refers to Whitewalliing: Art, Race & Protest in 3 Acts by Aruna D’Souza. The book—like Chan’s work and the TRII Biennial at large—poses some difficult questions for all those implicated in producing, consuming, and historicizing art and culture. “How [do we] approach the question of what art institutions hang on their walls without asking about the responsibilities of institutions—all manner of institutions—to make space for everyone, or at least be honest about whom theyheals, and light reveals even in the darkest circumstances. Earlier this year, Kenyan-British artist Phoebe Boswell emerged from an unrelenting series of traumatic events that served as the genesis for this new body of highly vulnerable and deeply sentient work. In this selfless survey of loss, grief, and triumph, Boswell presents an interlocking web of artistic gestures, in which her trace and pain are perpetually felt.

Minute rectangular voids are clipped from her raging, charcoal seascapes and strewn about the gallery as remote islands, as in You Won’t Hear Me There (2018); intrepid, figurative marks are cast atop the sea of white walls, illuminating a horizon line along which the artist’s self-image rises and sets, as in her site-specific installation Take Me To The Lighthouse (2018); and intimate self


staff presentations that lay bare select material and conceptual processes. This transparency and trust are the basis upon which CAN’s communication is built, encouraging the candid exchange of challenges and best practices across fields, audiences, and silos of work. As such, this network—with the distinct experiences it brings together—is uniquely poised to enact systemic and institutional change that keeps pace with the transformations taking place around us every day. The cohort’s diverse expertise and commitment to making Harlem a powerful place to live and work help shape our approach as we continue to have conversations throughout the neighborhood.

Another advisor with a background in education stresses the importance of a shift in professional attention during this historical moment: “For those departments that have not taken a program’s approach, that'sthe time, these words slapped up against the status quo and challenged inherited ideas that white privilege would forever prevail in oppressing equal rights to representation. Beyond the complex ways America’s visions for an equitable society have evolved and devolved since, no one could predict just how powerful a Black presidency would actually be—let alone the magnitude of the aftershocks it would provoke in its wake.

This month, the Smithsonian National Portrait Gallery unveiled two commissioned portraits of former President Barack Obama and former First Lady Michelle Obama by artists Kehinde Wiley and Amy Sherald. This ceremony, like most involving the Obamas, marked a celebration of historical firsts—in addition to Mr. Obama being the first African American represented in the presidential portrait collection, Sherald and Wiley are the first


important questions.

TC: I have seen students learn not just from artists, but from your institutions, about what it means to create the infrastructure in which those individuals can thrive, and where institutions care about them thriving. As teachers we want them to understand what it means to sustain a practice on an institutional level, and that it’s about investment in a community and a risky art practice.

PC: I would add to that incredibly important point, Tina. Some of us are thriving, but only barely when we look at the kind of support needed to do this work. We are still so far under-resourced, in staff and the funding required to do the work. Additionally, institutions of color also have expectations imposed upon us that predefine what community buildingis, and we frequently are in a responsive position rather than a proactive one in defining those ideas for ourselves. These are obstacles that we must overcome, and often do through collaboration.

Maker’s Mixtape celebrates artists whose practices animate processes foundational to the mixtape format— compilation, splicing, collage, looping and overlay. By remixing diverse source materials and juxtaposing voices to establish complex narratives, both recording and visual artists have transformed popular understandings of what it means to be a maker in the twenty-first century.

Over hip-hop’s decades-long history, visual artists such as Derrick Adams have been inspired to use collage as a political device, by infusing images of the black figure with detailed nuance, color and particularity. In his works on paper, Adams focuses on “the fragmentation and manipulation of


in your work?

D: Well, I believe most creatives resist the title of “black art” mainly because we may feel it is a contained space to exist in—a space given to us instead of chosen. The fact is our basic reality is one that has been constructed for us. I personally think it’s totally fine to own making “black art” just like people who make “black music,” it’s still music and you’re gonna dance to it when it’s played! Some believe that because it’s black music it has a significance not usually found in other types of music. So it’s more about understanding value systems in a way that will empower us to elevate the term. I’m Black, Black American, Afro-American, African American, American, etc, all rolled into one—Iwhen there are programs about black culture with all black casts made for non-black people in the hopes ofgiving particular audiences a hyper-representation of black life to illustrate how some people think we perform for each other. Some blacks even love it. This is usually so off in their depiction that it’s painful to watch.

N: What narratives do you think are omitted in depictions of the black experience? I know we talked the other day about the mystique of the successful, black artist. That there can be an omission of truth when it comes to the business of being an artist, and sustaining that life. What is the state of advocacy and mentorship in the art world?

D: Artists are like institutions and like everyone else we are part


at every turn. Furthermore, it employs the book's biographical framework to underscore activism's role in exposing the porous nature of the Constitution upon which this country has been so precariously built.

Diverging from the documentary convention of fragmented interviews with talking, tokenized heads, I Am Not Your Negro breaks all sorts of other codes, deconstructing traditional barriers between expert and novice, bourgeoisie and proletariat, performer and audience. Recalling Baldwin's plea that we allbear witness to the harsh realities of our times, clips that demand eye contact with historic oppressors are brought to the foreground. We are presented with scenes of brutality in their entirety to avoid sensationalizing or normalizing racial violence. Here, film editing is a tool to promote viewer engagement; it enables an audience to position itself inradio, this partnership amplifies the distinct voices of our resident artists, connects them to alumni of the program and broadcasts discussions of their work to a broader public. WNYC 93.9 FM and 820 AM are New York’s flagship public radio stations, and deliver a diverse suite of award-winning local and international programming to audiences worldwide.

Eaah year, this partnership kicks off with an artist talk at The Greene Space featuring the current artists in residence in conversation with the alumni of the program who have inspired them most. Moderated by a host from WNYC radio, the live conversation unearths shared connections to Harlem as a site of inspiration and experimentation, and provides unique insight into the Museum’s nearly fifty-year history through the personal accounts of those who comprise its


come in and be involved. But it is not a controlled situation that I envision in exactly one way; instead, it encompasses whatever happens in that moment. I get more concerned about the dialogue between the works, which is a conversation that of course the viewer becomes a part of. They walk around the painting or they don’t, that’s their choice. But my hope is that they can become part of the painting.

N: Can you explain how the materials themselves invite viewers to become part of the work?

M: People often think my paintings are made from microbeads that reflect light in a 1-2 relationship, but that’s a misconception. I actually use glass microspheres, or prisms that forge a triangular relationship between the painting’s surface, the light and thewithout exploring this freedom.

I am a realist looking for something that’s true. I want to have a true moment; I don’t want to live in a fantasy about the future, or be nostalgic over the past. I want to be right here, now, where there is no time. I’m big on that, living your life in the moment. That’s why I resist technology. People aspire to be like machines, and we are getting to be more and more mechanical. I worry that someone has to keep this true art connection happening, or else we will all become a bunch of robots.

N: And what excites you now, Mary? How do you plan to keep this true art connection alive?

M: I want to continue to bring paintings outdoors. My interest


banking system, plus the physical security ensured by gun rights, law-abiding neighbors, efficient police and military services.

But companies cannot offer American job-seekers this subsidy instead of wages because the Americans already are citizens.

If they want to hire an American instead of a foreign contract worker, companies have to pay Americans their full, unsubsidized marketplace value. So the hidden federal subsidy of citizenship-for-foreigners skews hiring practices in favor of foreign workers, much to the disadvantage of the 800,000 young Americans who graduate with skilled degrees each year.

Federal data shows that relatively few American graduates even get jobs in the high-skilled sectors which they studied — at great cost — in university. The U.S. Census Bureau reported in July that 2014 that:

74 percent of those who have a bachelor’s degreeAlso, the study by [@B21] indicated that the acceleration of AD in Ang II-infused mice had nothing to do with the Ang II-associated increase in blood pressure ([@B21]). This suggests that simply lowering blood pressure without also reducing the amount of Ang II in serum might adversely affect efforts to control the incidence of AD.

Macrophages Secrete Multiple Factors Involved in Ad Formation {#S4}
=============================================================

Studies have shown that macrophages secrete a variety of factors associated with AD, including metalloproteinases, ILs, vascular endothelial growth factor (VEGF), and others. These factors cause further macrophage recruitment, vascular SMC apoptosis and elastic fiber degradation, ultimately leading to AD.

Metalloproteinases That Play an Important Role in AD {#S4.SS1}
----------------------------------------------------

Metalloproteinases include an extensive zinc-dependent collagenases and elastases, which belong to the superfamily of metzincins, and are closely related


also closely related to acute lung injury caused by AD ([@B63]), and targeted depletion of macrophages suppresses AD together with spatial regulation of MMP-9 in the aorta ([@B24]). While MMP-3 itself is not secreted by macrophages, it is also significantly elevated in AD patients and can activate MMP-8 secreted by macrophages. This amplification cascade induces a widespread degradation of the aortic wall ([@B14]). At the same time, studies have shown that MMP-12 is a biomarker for some types of AD, and that it can even play a role in identifying patients at greater risk of AD ([@B37]; [@B4]; [@B27]). Taken together, these data on MMPs support the importance of macrophages in the development of AD.

The ADAMTS enzymes play important roles in many vascular diseases and, similar to MMPs,bind to wound-associated leukocytes, including macrophages ([@B10]; [@B2]). In addition, CD31 signaling in macrophages facilitates aortic remodeling and healing after dissection. An analysis of AD and intramural hematoma samples from patients undergoing surgical treatment revealed that the CD31 expression was lost by the M1 macrophages that densely penetrated into the acute aortic wall lesion sites, with CD31 re-expression accompanied the appearance of M2 and the disappearance of M1 macrophages at the valid aortic wall healing sites ([@B10]; [@B2]). M1 macrophages are considered to play a necessary role in early AD proinflammation, and the evidence also supports the view that the transition of wound-related macrophages from the proinflammatory M1 to the pro-reparative M2 phenotype plays a key role in driving inflammation resolution and promoting wound healing ([@B28]; [@B2]). These


metalloproteinase with thrombospondin motifs; STAT, signal transducer and activator of transcription; IL, Interleukin; GM-CSF, granulocyte macrophage-colony-stimulating factor; TNF-sR II, tumor necrosis factor receptor II; Socs 3, suppressor of cytokine signaling 3; TNF, tumor necrosis factor; TSP-1, thrombospondin 1; Th17-IL-17, T helper cell 17-interleukin -17; MMP, matrix metalloproteinase; SR-A1-Tyro3, A1 scavenger receptor-Tyro3 axis; miRNA, microRNA; Ang II, angiotensin II; iNOS mRNA, inducible nitric oxide synthase mRNA; SMCs, smooth muscle cells; VEGF, vascular endothelial growth factor.](fphys-11-00054-g002){#F2}

Increasingly, AD-related studies are shifting their focus to aortic inflammation and the role of macrophages in AD formation and repair ([@B10]; [@B2]). Thus far, efforts at understanding the contribution of inflammation and macrophages to AD have relied upon analyses of clinical samples and mechanistic studies in animal models. However, because of the contingency of lethalitytelegraph came about still exists and best of all it is mostly gravel and deserted. I'm using my trusty old Magellan Meridian GPS which works just fine with the KE100's 6 volt electrical system. I look for roads labled "Springfield road", or "Wire road" and take them when I find them. I discover an abandoned one lane bridge and take a photo of the KE on the bridge--sorry the photo is gone. I had to negotiate some rutted terrain to get to the bridge and little KE did fairly well. As others have mentioned the KE has minimal suspension travel. The good thing is that the bike is featherlight and this makes uneven terrain a lot less intimidating. I've jacked the pre-load on the rear shocks all the


to some useful above ground resource. For instance, a public zoo makes a good source of genetic material for a bio-lab facility. It should be obvious that a major metropolitan hospital would make an ideal source for human genetic material, as well as the perfect location to "field test" some new weapon-ized bacteria or virus. What is true of urban access points, is also true for rural access points. Many are located near the periphery of major urban populations. A large water reservoir, or a public camp ground located near a major highway, are good examples of useful above ground resources. Rural underground access points are favored as utility supply points, since the supply is less likely to be interrupted in time of national crisis. As we shall(rock, dirt, etc.) is produced by the boring process, thereby alleviating the need for above ground disposal sites. Another advantage is that tunnels can be bored through lose rock, sand, etc. or other locations that would be unsuitable for civilian boring methods (for instance, a river bed). Large underground cavities are also constructed using this technique.

Covert tunnel boring produces several phenomena that are detectable by surface observation. These phenomena are transitory, and will disappear shortly after tunnel completion. However the presence of these phenomena is unmistakable evidence that covert tunnel construction is taking place.

The method used to melt earth and rock employs electro-magnetic energy to disrupt the chemical bonds within the material. This method produces little or no heat as a by product of the melting process, and


is therefore very stealthy. However it does cause the evaporation of water to take place at an accelerated rate. Since the method is electro-magnetic, there is a certain amount of "leakage" radiation, and this is detectable by the odd effect it produces on surface water. In particular, the water will appear to rise from the ground as wisps of steam, even though the ground is cold. This phenomena is very noticeable during rain storms on cold winter nights. The steam does not rise into the air, as it would if the ground was actually warm, but instead forms a layer just above the surface.

Another side effect of covert tunnel boring is a peculiar rippling in road surfaces. This rippling is very slight, and most noticeable while driving atwas labeled with adequate clinical labels. The automated ROP screening system developed on such dataset would be more valuable in the clinical treatment. Future research may pay more efforts to explore the more suitable clinical labels rather than the "none ROP" and "plus-disease". And it would be a good tutorial for education on ROP. Secondly, we evaluated the good performance of DNNs on ROP detection in retinal fundus images. The method could be applied into other medical images analysis tasks, such as detection of diabetic retinopathy and OCT images classification. Thirdly, we developed and tested the proposed automated ROP screening system which would improve the quality of ROP care since it can be used in the routine ROP screening in hospitals and facilitate cooperation among hospitals to detect


ROP is the leading cause of childhood blindness worldwide \[[@bb0030],[@bb0035]\]. The situation is much more severe in developing countries, such as China. High neonatal survival rates and a large number of infants with low birth weight increase the number of premature infants at risk of ROP \[[@bb0040]\], and medical resources are scarce.

Automated ROP detection system is urgent and it appears to be a safe, reliable, and cost-effective complement \[[@bb0045],[@bb0050]\] to the efforts of ROP specialists, capable of increasing patient access to screening and focusing the resources of the current ophthalmic community on infants with potentially vision-threatening disease.

In these ROP screening programs, images of the retinal fundus are captured using fundus photography devices, such as RetCam3, and are used by the ophthalmologist to make a diagnosis. To implement theand *S*(*X*)^*j*^ is the *j*-th element of feature map *S*(*X*). The feature-binding block can reduce negative effects of the varying number of images in each case *X*, and can enhance the feature maps of distinguishable images while suppressing similar images that are found in many cases belonging to different categories. The third block is the classification block, which consists of several convolution layers and a softmax layer. It learns deep abstract features from feature map *S*(*X*), and maps the final feature into the corresponding label of the input case.

Id-Net and Gr-Net need to be trained on the large-scale dataset to obtain the network parameters. The training of a neural network refers to changing the parameters in it to improve network performance by deploying a learning algorithm, such as


the backpropagation (BP) algorithm. The network performance is described by a cost function that measures the distance between the network\'s output and the real label. After training, the neural network is expected to produce an output that is close to the corresponding real label. The training processes of Id-Net and Gr-Net were identical except for the training dataset used. Id-Net was trained on the identification dataset whereas the Gr-Net was trained on the grading dataset. The training process consisted of two phases. The first was offline pre-training. An Inception--BN network was trained on Image-Net. The learned parameters were used as the initial parameters of Id-Net and Gr-Net, which were then fine-tuned on the corresponding ROP dataset. Here, the retinal fundus images were resized from 1200\*1600\*3 to 240\*320\*3 andin multiple hospitals in China.

3.1. Large-scale ROP datasets {#s0055}
-----------------------------

We collected lots of images of ROP screenings from the Chengdu Women & Children\'s Central Hospital. Following the proposed image labeling method, there were 349 cases drop in the identification dataset and 222 cases drop in the grading task. The proposed datasets consist of three parts: developing data to build the DNN models, data for expert comparison, and data collected from web. The number of cases and images are listed in the [Table 1](#t0005){ref-type="table"}. The cases in developing data and data for expert comparison were collected from screenings of 869 infants. The summaries of the birth weights and gestation ages of the infants are presented in [Fig. 5](#f0025){ref-type="fig"}. As expected, most of them had low birth weights or were premature.


with one out and Carlos Gonzalez due up.- Carlos Gonzalez lined out to third. Runner on first with two outs and Jordan Pacheco due up.- Jordan Pacheco flied out to center to end the inning.

San Diego Top 2nd- Cameron Maybin grounded out short to first. None on with one out and Alexi Amarista due up.- Alexi Amarista singled to second. Runner on first with one out and Casey Kelly due up.- Casey Kelly sacrifice bunt to catcher. On the play, Alexi Amarista advances to second. Runner on second with two outs and Chris Denorfia due up.- Chris Denorfia grounded out short to first to end the inning.

Colorado Bottom 2nd- Tyler Colvin grounded out first to pitcher. None on with one out and Chris Nelson due up.- Chris Nelsonouts and Alexi Amarista due up.- Cameron Maybin advances to second on indifference. Runner on second with two outs and Alexi Amarista at the plate.- Alexi Amarista singled to left scored Cameron Maybin. Runner on first with two outs and Cory Burns due up.- Mark Kotsay enters the game for the Padres to pinch-hit for Cory Burns.- Pinch-Hitter Mark Kotsay singled to right. On the play, Alexi Amarista advances to second. Runners on first and second with two outs and Chris Denorfia due up.- Chris Denorfia grounded out short to first to end the game.


that all these horrific things that even my closest friends are saying have been indirectly directed at me. I know they don’t think of me in that light, but it is difficult to hear someone say such horrible things about a group of people that includes yourself and assume that you are still the exception.”

The events after the election upset Allison as well. “I was furious they were wasting my class time. It costs my parents $50 per lecture. I just wanted to leave,” she says, alluding to “in-class therapy sessions” after the election. “It made me feel like the villain. It was not like I could say anything. I don’t think my character is any lesser because I voted for Trump. Just because I voted for Trump,it doesn’t mean I’m not a feminist.”

Allison pauses for a moment, gathering her thoughts for her concluding remark. She leans in slightly towards me and says, “If Hillary had won, I wouldn’t have cried. I wouldn’t have said, fuck her, she’s not my President. You can’t fight fire with fire all the time.”

“I Can’t Even Live” -Sam

I meet Sam at Iveta Cafe. He stands well over 6 feet tall and wears a bright yellow hoodie which matches his long wavy blonde hair. He wanders around the restaurant for a few minutes before he finds my table.

Sam comes from a family of fiscal conservatives from suburban Los Angeles. His political views are influenced by talk radio and right-wing websites. Sam describes himself as “one of the only conservative students


not be openly conservative. I would look over my shoulder when I was talking to my dad about politics on the phone. People would get emotionally charged when I try to talk politics. I realized that I couldn’t live like this. After last quarter I decided that I would be open about it. People can make snap judgments by hearing things that I say. I have to very careful in how I phrase things. It stresses me out. I feel that I am on the hot seat.”

Shortly before the election, Sam veers away from the GOP candidate and votes for Gary Johnson instead. Although Sam agrees with many of Trump’s platforms, he dislikes the Donald’s environmental policies and personality flaws.

Sam tells me that he struggles to convey hisshort-term (5-week) studies from one center have indicated that iron sucrose may induce renal injury mediated by oxidative stress and inflammation \[[@CR19]--[@CR23]\]. However, the recently published REVOKE study, which randomized patients with ND-CKD to IV iron sucrose or oral iron, showed neither a difference in renal function decline (based on GFR measured by iothalamate clearance) nor in proteinuria during follow-up lasting up to 2 years \[[@CR24]\]. Confirmatory data are clearly important.

The FIND-CKD trial included protocol-specified monitoring of renal function in over 600 patients with ND-CKD, based on estimated GFR (eGFR), throughout the 1-year study \[[@CR25]\]. Data were analyzed to compare renal outcomes in patients randomized to IV FCM using two different dosing regimens aiming for different target ferritin concentrations, with those in patients receiving oral iron.

Methods {#Sec2}
=======

Study design {#Sec3}
------------

FIND-CKD


As a *post hoc* sensitivity analysis, GFR was also estimated by the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula \[[@CR27]\]. CKD-EPI values were calculated centrally using locally-measured serum creatinine levels. The percentage of patients starting dialysis was a further pre-specified secondary endpoint.

Statistical analysis {#Sec7}
--------------------

All analyses of renal function were exploratory. Analysis of covariance (ANCOVA) modeling was used to compare the change in eGFR values from baseline to month 12 between groups based on least square (LS) mean values using a repeated fixed effects model with treatment, visit and pooled country as factors, baseline eGFR as covariate, and treatment-by-visit as an interaction. Change in eGFR at month 12 was summarized in subpopulations of patients according to age (≤ or \> median), gender, body mass index (BMI, ≤ or \> median), baseline systolicmL/min/1.73 m^2^ Mean (SD)35.6 (13.8)32.1 (12.7)33.4 (14.5) ≥ 60, n (%)7 (7.2)4 (4.5)7 (4.2) 30 to \<60, n (%)54 (55.7)40 (44.9)83 (49.7) 15 to \<30, n (%)32 (33.0)39 (43.8)65 (38.9) \< 15, n (%)4 (4.1)6 (6.7)12 (7.2)Change from baseline to month 12, LS mean (SE) (MDRD), mL/min/1.73 m^2^0.7 (0.9)-0.9 (0.9)-0.9 (0.7)  *p* value for change vs oral iron^a^0.150.99ReferenceRelative change from baseline to month 12, LS mean (SE) (MDRD), %3.1 (2.6)-2.4 (2.7)-2.2 (2.0)  *p* value for change vs oral iron^a^0.0980.95ReferenceeGFR (CKD-EPI) mL/min/1.73 m^2^*n* = 82*n* = 68*n* = 137 Mean (SD) at baseline33.5 (11.9)32.0 (11.8)32.5 (13.4) Mean (SD) at month 1234.8 (13.1)31.1 (13.5)31.0 (14.8) Change, LS mean (SE), mL/min/1.73 m^2^1.3 (1.0)-1.2 (1.0)-1.7 (0.7)  *p* value for change vs oral iron^a^0.0120.68ReferenceeGFR was estimated by the MDRD-4 equation \[[@CR27]\] at the local laboratory*CI* confidence interval, *CKD-EPI* Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), *eGFR* estimated GFR, *FCM* ferric carboxymaltose, *LS* least squares,


Another limitation is that urinary protein excretion and biomarkers of renal tubular toxicity were not recorded. Also, patients previously showing a rapidly progressive loss of renal function at screening were excluded from the study. Indeed, it is remarkable that the annual loss of eGFR was no more than 1.6 mL/min/1.73^2^ in any group. Other eligibility criteria for the study may have contributed to this stability, notably exclusion of patients with previous eGFR loss \>12 mL/min/1.73 m^2^/year but also, for example, those with poorly controlled hypertension. Moreover, approximately three-quarters of patients were receiving an ACE inhibitor or an angiotensin II receptor antagonist. Lastly, in terms of the study design, the absence of a placebo arm precludes a comparison of renal function using IV iron versus no treatment and would have contributed toVifor Pharma. Fernando Carrera has no conflicts of interest to declare. Kai-Uwe Eckardt has received speaker's fees and/or consultancy fees from manufacturers of ESAs and IV iron, including Affymax, Amgen, Bayer, Johnson & Johnson, Hoffmann-La Roche and Vifor Pharma. Carlo Gaillard has received speaker's fees, honoraria and consultancy fees from manufacturers of ESAs and IV iron, including Amgen, Pharmacosmos, Hoffmann-La Roche, Takeda and Vifor Pharma. David Van Wyck is an employee and stockholder of DaVita Healthcare Partners, Inc. Yvonne Meier and Sylvain Larroque are employees of Vifor Pharma. Simon D Roger has received speaker's fees, honoraria and consultancy fees from several manufacturers of ESAs and IV iron, including Amgen, Hoffmann-La Roche, Janssen-Cilag, Novartis, Sandoz, Takeda and Vifor Pharma.

Consent for publication {#FPar4}
=======================

No individual data are presented.

Ethics approval and consent


I propose in the interim between now and whenever Season Two of the Jelly RP is released a new Role-Play, a murder mystery. I plan on serving as the narrator and certain NPCs of the story, whilst everyone else would be given created personas in which they attempt to act out. Overall, there are but two main roles to be concerned with: Wolf and Sheep. The sheep's goal is to survive which means figuring out who the killer is before he/she can murder everyone. The wolf's goal is to, well, kill everyone. The available characters for the RP and their respective actors will be posted once the role-players have signed on.

PLOT SUMMARY:"Guests, friends, family: come one and all to House Winter for the magnificent fifty-eighth birthday party ofFINE ARTIST

Elisa McLeod

Depicting botanical imagery captured through the lens of a camera my oil paintings on canvas explore the middle ground between representational and abstract art. Photographs are the starting point of my creative process and act as a form of sketchbook – the inspiration for which most often reveals itself to me whilst out walking in my home region of Cornwall. Absorbed by studying the intricate details of a plant from the ground up, a shallow depth of field enables me to record the boundless shapes of a large blurred leaf in the foreground whilst focusing on one small, delicate and often unexpected detail.

Light is a fundamental theme in my paintings – an amalgamation of dappled sunlight bursting through the cracks and sharp edged shards of light


is a system ${\mathbf{H}}(\cdot)$ that takes a graph signal ${\mathbf{s}}$ as an input, processes it, and produces another graph signal ${\mathbf{\tilde{s}}}={\mathbf{H}}({\mathbf{s}})$ as an output. A basic non-trivial filter defined on a graph $G=({\mathcal{V}}, {\mathbf{A}})$, called the *graph shift*, is a local operation that replaces a signal value $s_n$ at node $v_n$ with the linear combination of values at the neighbors of node $v_n$ $$\label{eq:graph_shift_n}
\tilde{s}_n = \sum_{m\in{\mathcal{N}}_n}{{\mathbf{A}}_{n,m} s_m}.$$ Hence, the output of the graph shift is given by the product of the input signal with the adjacency matrix of the graph: $$\label{eq:graph_shift}
{\mathbf{\tilde{s}}}=
\begin{bmatrix} \tilde{s}_0 & \ldots & \tilde{s}_{N-1} \end{bmatrix}^T
={\mathbf{A}}{\mathbf{s}}.$$ The graph shift is the basic building block in [$\mbox{DSP}_{\mbox{\scriptsize G}}$]{}.

All linear, shift-invariant[^3] graph filters in [$\mbox{DSP}_{\mbox{\scriptsize G}}$]{} are polynomials in the adjacency matrix ${\mathbf{A}}$ of the form [@Sandryhaila:13] $$\label{eq:h_A}
h({\mathbf{A}}) = h_0\operatorname{\mathbf{I}}+ h_1{\mathbf{A}}+the eigenvalues are ordered as $$\label{eq:real_lambda_condition}
\lambda_m < \lambda_n,$$ then the total variations of their eigenvectors satisfy $$\label{eq:frequency_ordering_real}
\operatorname{TV_G}({\mathbf{v}}_m) > \operatorname{TV_G}({\mathbf{v}}_n).$$

Since the eigenvalues are real, it follows from  that the difference between the total variations of the two eigenvectors satisfies $$\begin{aligned}
\nonumber
\operatorname{TV_G}({\mathbf{v}}_m) - \operatorname{TV_G}({\mathbf{v}}_n)
&=& \left|1-\frac{\lambda_m}{|\lambda_{\scriptsize \textrm{max}}|}\right| - \left|1-\frac{\lambda_n}{|\lambda_{\scriptsize \textrm{max}}|}\right| \\
\nonumber
&\overset{(a)}=& \left(1-\frac{\lambda_m}{|\lambda_{\scriptsize \textrm{max}}|}\right) - \left(1-\frac{\lambda_n}{|\lambda_{\scriptsize \textrm{max}}|}\right) \\
&=& \frac{\lambda_n-\lambda_m}{|\lambda_{\scriptsize \textrm{max}}|} > 0,\end{aligned}$$ which yields . Here, equality (a) follows from .

As follows from Theorem \[thm:ordering\_real\], if a graph has a real spectrum and its frequencies are ordered as $$\label{eq:order_real}
\lambda_0 > \lambda_1 > \ldots > \lambda_{M-1},$$ then $\lambda_0$ represents the lowest frequency and $\lambda_{M-1}$ is the highest frequency. Moreover, the ordering  is a unique ordering of all frequencies from lowest to highest. This frequency ordering for matrices with real spectra is visualized in Fig. \[fig:spectrum\_real\].

\

The next theorem extends


a similarity value to a hyperlink).

For both datasets, we consider trade-offs between the two parts of the objective function in  ranging from $1$ to $100$. In particular, for each ratio of known labels $0.5\%$, $1\%$, $2\%$, $3\%$, $5\%$, $7\%$, $10\%$ and $15\%$, we run experiments for $199$ different values of $\alpha\in\{ 1/100, 1/99,\ldots, 1/2, 1, 2,\ldots, 100\}$, a total of $8\times 199 = 1592$ experiments. In each experiment, we calculate the average classification accuracy over 100 runs. After completing all experiments, we select the highest average accuracy for each ratio of known labels.

For comparison, we also consider the Laplacian quadratic form , and solve the minimization problem $$\label{eq:minimization_Laplacian}
{\mathbf{s}}^{\scriptsize \textrm{(predicted)}} = \underset{{\mathbf{s}}\in{\mathbb{R}}^N}{{\mathbf{arg min}}}\, \left( \operatorname{S}_2^{(L)}({\mathbf{s}}) + \alpha ||\operatorname{\mathbf{C}}({\mathbf{s}}^{{\scriptsize \textrm{(known)}}} - {\mathbf{s}})||_2^2 \right),$$ where we vary $\alpha$ between $0.01$ and $100$location data with third-parties unless explicity allowed by the user.

The firm, however, admitted that due to a bug location data was sometimes collected even if iPhone location services had been turned off.

The bug was fixed in a subsequent software update.


(VF) was separated into 4 groups with points from 1 to 4: mild, moderate, advanced and end stage. GI was then defined as VF\*meds\*IOP and separated into GI group 1 = mild, GI group 2 = moderate, GI group 3 = advanced, and GI4 = severe defined based on glaucoma index scores of "≤4", "4\<;GI≤8", "8\<GI≤16", and "\>16," respectively. The main outcome measure was the reduction of IOP. Secondary outcome measures included reduction of medication and a Kaplan-Meier survival analysis. Baseline characteristics were analyzed by the Kruskal-Wallis and chisquare tests for continuous and categorical variables between GI groups, respectively. Univariate linear regression was performed first and those demographics found to be statistically significant were included into the multivariate regression analysis. Kaplan-Meier was used for survival-curve analyses. Surgical successafter demonstrating by a rigorous statistical matching method, coarsened exact matching ^[@ref-13]^, that phacoemulsification does not contribute significantly to IOP reduction when done at the same time ^[@ref-6]^ or in a surgery prior to trabectome surgery ^[@ref-14]^. As in our prior studies ^[@ref-14]^, phaco-trabectome patients had a lower preoperative IOP. This study focused on stratification of outcomes by glaucoma index and did not apply advanced matching strategies that we applied elsewhere ^[@ref-6],\ [@ref-14],\ [@ref-15]^ to compare two groups. Hence, one cannot conclude from this study that cataract surgery is causatively linked to a diminished IOP reduction when compared to trabectome-only patients. On the contrary, an IOP reduction in many of our phaco-trabectome patients is simply not necessary to the same degree.

The results of this study match established risk


Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

**Competing interests:**No competing interests were disclosed.

27

6

2016

Version 2

I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

10.5256/f1000research.9711.r14600

Referee response for version 2

Sarkisian Jr.

Steven R.

1

Referee

University of Oklahoma College of Medicine, Oklahoma City, OK, USA

**Competing interests:**Dr Sarkisian is a consultant to New World Medical, Sight Sciences, Beaver Vistec International, Glaukos, Alcon, Aeon Astron, and InnFocus. He has received research funding from Glaukos, Transcend, and Aeon Astron.

27

6

2016

Version 2

I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

10.5256/f1000research.9096.r13594

Referee response for version 1

Sarkisian Jr.

Steven R.

1

Referee

University of Oklahoma College of Medicine, Oklahoma City, OK, USA

**Competing interests:**Dr Sarkisianis a consultant to New World Medical, Sight Sciences, Beaver Vistec International, Glaukos, Alcon, Aeon Astron, and InnFocus. He has received research funding from Glaukos, Transcend, and Aeon Astron.

20

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2016

Version 1

This is an interesting study demonstrating that ab interno trabeculectomy is an appropriate surgery to attempt to control more than mild glaucoma. Ab interno trabeculotomy is a growing trend in glaucoma surgery, not just with the trabectome device, but also with the dual blade that is recently on the market from New World Medical, and also the Sight Sciences device called TRAB 360. The trend toward ab interno, non-penetrating surgery in patients with not only mild, but even advanced glaucoma demonstrates our aversion for conventional filtration surgery and the significantly high complication rate seen with it. I am grateful to


the most prudent choice.

.

At the other end of the spectrum in ocular hypertension patients with no current measurable damage, is the risk profile of Trabectome combined with phacoemulsification reasonable, compared to the risk and cost of drops or SLT as alternatives? We know that the effectiveness of only one iStent, the FDA approved norm in the US, is quite often not sufficient to reduce pressures adequately.

There was another issue to be considered. The grading system uses pressure as one of the components and also uses the pressure drop as the metric of success. There be some circular reasoning involved, as the initial pressure head itself is a determinant of the resulting pressure drop using drops, lasers or surgery. Unfortunately the study can not be replicated exactly due to patient confidentiality considerations.

The validated glaucoma severity scale. from their previous paper in PLoS, uses simple-to-obtain inputs: IOP, number& Malvankar-Mehta, M. S. Projected Cost Comparison of Trabectome, iStent, and Endoscopic Cyclophotocoagulation Versus Glaucoma Medication in the Ontario Health Insurance Plan. J. Glaucoma (2013). doi:](http://paperpile.com/b/YJPHco/qMZI) [10.1097/IJG.0b013e31829d9bc7](http://dx.doi.org/10.1097/IJG.0b013e31829d9bc7)[Brusini, P. & Filacorda, S. Enhanced Glaucoma Staging System (GSS 2) for classifying functional damage in glaucoma. J. Glaucoma 15, 40--46 (2006).](http://paperpile.com/b/YJPHco/3n0f)[Mills, R. P. et al. Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease. Am. J. Ophthalmol. 141, 24--30 (2006).](http://paperpile.com/b/YJPHco/vV5A)[Advanced Glaucoma Intervention Study. 2. Visual field test scoring and reliability. Ophthalmology 101, 1445--1455 (1994).](http://paperpile.com/b/YJPHco/Tp8j)[Zhang, X. et al. Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography. Am. J. Ophthalmol. 163, 29--37 (2016).](http://paperpile.com/b/YJPHco/koWD)

10.5256/f1000research.9096.r13590

Referee response for version 1

Mascarenhas

Kristy G.

1

Referee

Hartford Hospital/Middlesex Hospital, Middletown, CT, USA

**Competing interests:**No competing interests were disclosed.

10

5

2016

Version 1

This was an interesting analysis of the use of


S., Brown, E. N. & Loewen, N. A. Glaucoma Surgery Calculator: Limited Additive Effect of Phacoemulsification on Intraocular Pressure in Ab Interno Trabeculectomy. PLoS One 11, e0153585 (2016).](http://paperpile.com/b/YJPHco/BKqS)[Iacus, S. M., King, G. & Porro, G. Causal Inference without Balance Checking: Coarsened Exact Matching. Polit. Anal. 20, 1--24 (2012).](http://paperpile.com/b/YJPHco/16nOu)[Parikh, H. A., Bussel, I. I., Schuman, J. S., Brown, E. N. & Loewen, N. A. Coarsened Exact Matching of Phaco-Trabectome to Trabectome in Phakic Patients: Lack of Additional Pressure Reduction from Phacoemulsification. PLoS One 11, e0149384 (2016).](http://paperpile.com/b/YJPHco/PBV2H)[Akil, H. et al. Clinical Results of Ab Interno Trabeculotomy Using the Trabectome in Patients with Pigmentary Glaucoma compared to Primary Open Angle Glaucoma. Clin. Experiment. Ophthalmol. (2016). doi:](http://paperpile.com/b/YJPHco/08B3G) [10.1111/ceo.12737](http://dx.doi.org/10.1111/ceo.12737)[Gedde, S. J. et al. in Am J Ophthalmol 153, 804--814.e1 (2012 Elsevier Inc, 2012).](http://paperpile.com/b/YJPHco/XWQx)[Gedde,S. J. et al. Treatment Outcomes in the Tube Versus Trabeculectomy (TVT) Study After Five Years of Follow-up. Am. J. Ophthalmol. 153, 789--803.e2 (2012).](http://paperpile.com/b/YJPHco/txsS)[Taylor, H. R. Glaucoma: where to now? Ophthalmology 116, 821--822 (2009).](http://paperpile.com/b/YJPHco/gUFg)[Rein, D. B. et al. The cost-effectiveness of routine office-based identification and subsequent medical treatment of primary open-angle glaucoma in the United States. Ophthalmology 116, 823--832 (2009).](http://paperpile.com/b/YJPHco/NCPk)[Iordanous, Y., Kent, J. S., Hutnik, C. M. & Malvankar-Mehta, M. S. Projected Cost Comparison of Trabectome, iStent, and Endoscopic Cyclophotocoagulation Versus Glaucoma Medication in the Ontario Health Insurance Plan. J. Glaucoma (2013). doi:](http://paperpile.com/b/YJPHco/qMZI) [10.1097/IJG.0b013e31829d9bc7](http://dx.doi.org/10.1097/IJG.0b013e31829d9bc7)[Brusini, P. & Filacorda, S. Enhanced Glaucoma Staging System (GSS 2) for classifying functional damage in glaucoma. J. Glaucoma 15, 40--46 (2006).](http://paperpile.com/b/YJPHco/3n0f)[Mills, R. P. et al. Categorizing the stage of glaucoma from pre-diagnosis to end-stage


Q:

How to compare if a timestamp falls in range of a given time period in Java

In my Java Spring MVC Web Application, I am trying to write a program to save some data with a time stamp along with it. But I have a specific time period which I have to exclude.
For example, I have the following timestamp: Sat Jul 28 17:03:00 IST 2018 which is a Java Date object. Before saving to the database I have to check if this time comes inside a specified range if then I have to get the next minute after the end of the time range.
But the time range is a string of the following format:
String startTime =  "5:03 PM";
String endTime = "5:10 PM";

So my if my timeStampout from Google when user log out from my website.

A:

setPrompt to 'select_account'. Google will ask to select account each time authentication request is made .
I do not think your users are happy with being logged out after logging out your page... They can change their account within the Google page.
This is the url for logging out:
accounts.google.com/logout

You can pass a redirect parameter there:
accounts.google.com/logout?continue=http://www.google.com/

But this parameter just work with links to Google services. There is no way to link your own page (not even with Google search redirect links). I think there is a very good reason for this. You should not log out your users from another foreign service for any reason.


you can’t support,” Julien said. “I don’t think I can support Shawn on those actions. ... I don’t think we like seeing our players do that.”

Thornton didn’t take questions from reporters, but did say: “I obviously got caught up in the moment. … I’m sorry that the silly incident kind of overshadowed how my teammates played and the great win and how good the series has been.”

Mike Loftus may be reached at mloftus@ledger.com. On Twitter.com: @MLoftus_Ledger.Inhibitory effect of spice oils on lipase and mycotoxin production.
Five spice oils were tested for their inhibitory activity towards the growth, respiration, lipase and mycotoxin productions by Aspergillus parasiticus var. globosus IMI 120920 and A. fumigatus. Cumin, onion, garlic and clove oils completely inhibited sterigmatocystin production. Cumin, onion and clove oils significantly suppressed aflatoxin production. Most of tested oils exhibited considerable inhibition on mycelial growth. Incorporation of these oils in basal medium suppressed lipase production with variable degrees. Onion oil was the most effective one. All spice oils significantly reduced or completely suppressed CO2 evolution of A. fumigatus, whereas CO2 evolution of A. parasiticus was slightly enhanced by these oils except with cumin and clove. Our results suggest that the use of spice oils may offer some advantage


String = "caps";
  public static const SMALL_CAPS: String = "smallCaps";
  public static const UPPERCASE: String = "uppercase";
  public static const LOWERCASE: String = "lowercase";
  public static const CAPS_AND_SMALL_CAPS: String = "capsAndSmallCaps";
}
}
that is actually superior to the Hebrew bible in terms of cross verification.

I personally never though to get a sniff of such material except perhaps from India which majorly felt the effects but did not see the event itself. Northern Europe and Turkey were well positioned to see and survive the event.

.

Gobekli Tepe recorded a Devastating Comet Strike

Sarah Knapton writes “Ancient stone carvings confirm that a comet struck the Earth around 11,000BC, a devastating event which wiped out woolly mammoths and sparked the rise of civilizations”. Experts at the University of Edinburgh analyzed mysterious symbols carved onto stone pillars at Gobekli Tepe in southern Turkey, to find out if they could be linked to constellations. The markings suggest that a swarm of comet fragments hit Earth at the


farming began, allowing the rise of the first towns.

Edinburgh researchers said the carvings appear to have remained important to the people of Gobekli Tepe for millennia, suggesting that the event and cold climate that followed likely had a very serious impact.

Dr Martin Sweatman, of the University of Edinburgh’s School of Engineering, who led the research, said: “I think this research; along with the recent finding of a widespread platinum anomaly across the North American continent virtually seal the case in favor of (a Younger Dryas comet impact).

“Our work serves to reinforce that physical evidence. What is happening here is the process of paradigm change.

“It appears Göbekli Tepe was, among other things, an observatory for monitoring the night sky. One of its pillars seems to have served as a1. Introduction {#s1}
===============

A good magic trick is enjoyable for the audience; a great magic trick makes it seem, if only for a moment, that a miracle has occurred right in front of their eyes; Ortiz ([@B29]) provides excellent discussions of what constitutes an exemplary trick. Magicians will go to great lengths to perfect a method that results in this type of theatrical impact. Taking into account all the constraints, both physical and psychological, that must be satisfied for a certain trick to exhibit magical qualities, performers will try to construct the best presentation possible. In this paper we refer to trick technology as being the combination of physical and psychological processes underpinning the technical effect. A trick\'s overall efficacy is dependant not only on the trick technology but


under consideration works, to correctly abstract the various elements without missing crucial steps in the method. This technique of abstracting specialist knowledge to build a model is commonly used in various automated expert systems used for medical diagnosis and financial risk assessment, amongst others; see Russell and Norvig ([@B33]).

The identification and analysis of the problem domain is naturally coupled with elements reflecting the psychological phenomenon being exploited during the trick, for example in the jigsaw trick we describe later we need to include a constraint on maximum line length increases commensurate with a spectator not noticing these length changes. Rather than model this phenomena directly we incorporate such constraints through encoding the results from subject empirical data, that is we run a series of experiments to qualify thegeneral, but loves a particular trick, the calibrated rating will positively reflect this. This method accentuates weak ratings. A useful measure of how well a trick is received by a group of participants is the difference between the average (mean) rating given to magic in general, and the average (mean) rating given to the particular trick. The smaller the value the better (the theoretical minimum is minus four, though anything close to zero is very good).

We performed experiments (*N* = 96) asking participants to freely choose words to describe their reactions to a range of classic magic tricks, the results of which are shown in Figure [2](#F2){ref-type="fig"}. The intention here was to gather data about the type of descriptive words people use when asked to give a reaction


rectangles on the puzzle; we investigated the amount of cognitive load this produced. Previous studies, see Mandler and Shebo ([@B26]), suggest a response time of 250--350 ms per item counted above the subitizing range (the number of items that are able to be counted in a negligible amount of time without much cognitive effort; generally thought to be up to 4 items). We performed our own online experiment to determine the rate at which subjects (*N* = 49) were able to count rectangles on a screen, see Figure [5](#F5){ref-type="fig"}. During our experiment, it was necessary for the participants to find and press an on-screen button, indicating the numbers of rectangles they had counted, and another button to submit their count. From the data, it is estimated that thisyields a unique set of three Suits. Other orderings can be found such that consecutive cards may be differentiated by multiple categories; for example, Suits, Color, and Picture Cards. A suitable set of fishing questions then need to be deployed to recover the actual identity.

These kinds of orderings of cards characteristics may be represented as a computational tree structure, defined in Knuth ([@B18]), a category at each level determining which tuples (sequences) of cards are placed at which node (branching points), ending in leaf nodes that contain only one tuple of cards of the requisite length. The trick Suitability\'s tree has only one level beyond the root (the start node), thus requiring only one fishing question per card (which suit it belongs to).

Generally, the shorter the fishing trip


set of playing cards that deconstructs at each level of the tree into a set of cards distinguished by category. Additionally at each leaf node there must be only one set of cards of a given length and all cards in the deck must be in at least one leaf node. See Figure [9](#F9){ref-type="fig"} for a simple example of this type of structure as used in a magic trick.

![**A simple example of how a deck can be cyclically ordered, breaking down into tuples of length two, within a four card deck**. This is a very simple tree with only one level below the root. Each pair of cards dealt from the deck will be a unique sequence of red and black cards. A magician can dispense two consecutivestate. It should be noted that Eq. (\[eq:bra2p\]) represents an antisymmetrized 2-particle state. Performing an integration over one of the $k_i$, one obtains a 2-particle state in a mixed representation of one particle in a bound harmonic oscillator while the other is in a plane wave state $$\left| n_1 l_1 j_1 k_2 l_2 j_2 J T \right\rangle = \int_0^\infty dk_1 \, k_1^2
R_{n_1, l_1}(\alpha k_1) \, \left| k_1 l_1 j_1 k_2 l_2 j_2 J T\right\rangle
..
\label{eq:branp}$$ Here $R_{n_1, l_1}$ stands for the radial oscillator function and the oscillator length $\alpha = 1.72 $ fm$^{-1}$ has been selected. This choice for the oscillator length corresponds to an oscillator energy of $\hbar \omega_{osc}$ = 14 MeV. Therefore the oscillator functions are quite appropriate to describe the wave functions of the bound single-particle


non-diagonal part of the density matrix, which is given in the “box basis,” defined in the preceeding subsection, by $$\tilde n_{lj} (k_i, k_n) = \int_{-\infty}^{\epsilon_F} dE\,
\frac{1}{\pi} \mbox{Im} \left(
\sum_{\alpha, \beta} \left\langle k_i \vert \alpha \right\rangle_{lj}
g_{lj} (\alpha ,\beta ;E )
\left\langle \beta \vert k_n \right\rangle_{lj}\right) , \label{eq:ndia}$$ and contains, as before in the case of the spectral function, a continuous contribution and a part originating from the quasihole states $$\tilde n_{lj}^{qh} (k_i, k_n) = \sum_{\Upsilon} Z_{\Upsilon lj}
\left\langle k_i \vert \Upsilon \right\rangle_{lj}
\left\langle \Upsilon \vert k_n \right\rangle_{lj} . \label{eq:nqh}$$ The sum in this equation is restricted to quasihole states with energies below the Fermi energy $\epsilon_F$. With this density matrix the expectation value for the square of the radius can be calculated according to $$\left\langle \Psi^A_0 \right| r^2 \left| \Psi^A_0 \right\rangle =
\sum_{l,j} 2(2j+1)\sum_{i,n=1}^{N_{\rmthe contributions originating from the quasihole states and the continuum of 2h1p configurations (see Eq. (\[eq:renor\])). This separation into the two parts is displayed in Fig. \[fig:specpw\] for the energy integrated spectral function (including all energies below the Fermi energy $\epsilon_F$) for different partial waves $lj$. This figure displays quite clearly that the momentum distribution at small momenta is dominated by the quasihole contribution (for those partial waves for which it exists) whereas the high-momentum components are given by the continuum part (see also Ref. [@brief]).

This implies that a nucleon knockout reaction with small energy transfer, leaving the remaining nucleus (e.g. $^{15}$N in the present case as all results presented here refer to $^{16}$O) in its ground state or in the lowest state with angular momentum and parity defined by


Q:

How to add a common string in every randomly generated string Javascript

I am generating random strings using the below function in node.js. I wanted to know if there is any way to create text strings appropriately with a common string within every randomly generated string.
EDIT: The common string can be in any location of the generated string
For example:
Randomly generated string - Cxqtooxyy4
Can I add 'abc'  or 'ABC' within that string like this - Cxqtoabcoxyy4 or CxqtoABCoxyy4 respectively.
My Code -
var randomTextArrayGeneration = function(size)
{
    var text = "";
    var possible = "ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789";
    for(var i=0;i<size;i++)
        text += possible.charAt(Math.floor(Math.random() * possible.length));
    return text;
}

Can anyone tell me how do I doare negligible. Heat loss due to conduction along the parts with spatial temperature differences can be minimized in several obvious ways.
Another object was to produce an engine where there is essentially no loss of pressure around pistons or blades. Prior engines would produce localized circulations and turbulence especially where the blades are close to the blade casing. There is rapid relative motion between closely spaced components in most if not all prior art In my invention the casing which is touched by the working fluid moves with the same rotation rate as the blades, so the blades do not move with respect to the casing, except for angle adjustments.
Another object of the current invention is to produce an engine comprising a centrifugal compressor and a reverse operated compressor


  VendorFinding Load (3.2ms)  SELECT `vendor_findings`.* FROM `vendor_findings` WHERE (ContactPerson = 'Myself')
=> #<ActiveRecord::Relation [#<VendorFinding vendor_findings_id: 905, ContactPerson: "Myself", contact_email: nil, Status: nil]>

It pretends that it updated the DB, but when I check MySQL DB, the record isn't there and the record count total is the same as before the operation. There is no validation going on on the DB side and the type of the parameters are VARCHAR(65) except the id, which is INT.
I'm newish to rails and am trying to get ActiveRecord to interact with a legacy database host: <dbname>.db.<corpname>.com
   port: 8200
   database: Safety
   encoding: utf8
   collation: utf8_general_ci
   pool: 5
   <password_stuff_removed_for_stack_overflow>

 test:
   adapter: sqlite3
   database: db/test.sqlite3

A:

Your problem is in this part of database.yml:
 development:
   adapter: mysql2
   host: <dbname>.db.<corpname>.com
   port: 8200
   database: Safety
   encoding: utf8
   collation: utf8_general_ci
   pool: 5
   <password_stuff_removed_for_stack_overflow>

   adapter: sqlite3
   database: ":memory:"

The first part of this code sets your development database to be the same as your production database. Then the second part of the code overrides your earlier settings and sets the database to be database: ":memory:" which is basically a temporary database that's deleted as soon


MISSING PERSONS FEAT DALE BOZZIO MISSING IN ACTION LP VINYL NEW 33RPM

Regular price£26.99Sale

Do Or DieHello, HelloWalk Into the SunCovert OperationThe More We LoveThe Speed of LightAll the WayIf I Gave You My MindSiren SongCrisis in OverdriveWalking in L.A. (Acoustic)Hello, Hello (Radio Remix)contacts and only 39\[0--205\]pg/mL for TST− contacts) with production of IL-13 low but still significantly higher than TST− HHC (30\[12--45\]pg/mL compared to 24\[7--51\] for TST+ and 8.5\[0--16\] for TST− HHC. Production of IL-18 was very low and was the only cytokine with no significant difference between any of the three groups (median\[IQR\] = 0.5\[0--6.3\] for TB cases, 0.5\[0--3.1\] for TST+ contacts and 0\[0--6.1\] for TST− contacts ([Fig. 1G](#pone-0012365-g001){ref-type="fig"}). Analysis of the proportion of responders was also performed as this further contributes to our understanding of the pathogenesis of TB. For each cytokine, responders were determined based on production \>2SD above the mean level for the corresponding cytokine in the background sample. Following PPD stimulation there was a significantly higher proportion of TB cases and TST+ contacts producing IFN-γ, IL-13 and


3 groups was similar. A significantly higher proportion of TB cases and TST+ contacts produced both IFN-γ (p\<0.001 and p\<0.05 respectively) and IL-17 (p\<0.001 and p\<0.05 respectively) compared to TST− contacts ([Fig. 2H](#pone-0012365-g002){ref-type="fig"}). In addition, the proportion of TST+ contacts producing IL-13 was significantly higher than for TST− contacts (p\<0.05; [Fig. 2H](#pone-0012365-g002){ref-type="fig"}). However, no difference in the proportion of responders was seen between TB cases and TST+ contacts for any cytokine. Only 55% of TB cases and 35% of TST+ contacts could be deemed to be responders based on IFN-γ production (compared to almost 90% following PPD stimulation), however, this was still significantly higher than TST− contacts with \<5% producing IFN-γ at levels above background (mean+2SD).

![Cytokine responses following EC stimulation.\
Whole blood from TB cases (n = 36), TST+ (n = 20) andassessed by luminex technology for secretion of cytokines. A) IFN-γ. B) TNF-α, C) IL-10, D) IL-12(p40), E) IL-13, F) IL-17 and G) IL-18. Line indicates median. Data were analysed using Tweedie distributions with p-values indicating significant differences after adjustment for age and sex. H) Percentage of responders (prior to adjustment for age and sex) producing IFN-γ, IL-10, TNF-α, IL-12, IL-13, IL-17, IL-18. Dark bars = cases, grey bars = TST+ contacts, white bars = TST− contacts; p-values are indicated and refer to comparison with TST− contacts.](pone.0012365.g003){#pone-0012365-g003}

Multivariate analysis for classification of TB cases, TST+ or TST− contacts {#s2d}
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We next used multivariate analysis to attempt to correctly classify subjects into TB cases, TST+ or TST− household contacts ([Table 1](#pone-0012365-t001){ref-type="table"}). Following PPD stimulation, analysis of IFN-γ alone resulted in 74% correct classification into TB cases and TST+