along with a Japanese sword, a savage-looking spear, and a crutch. Aiyer limps badly, the aftereffects of two disastrous automobile accidents, but his back is erect.

Ryan Lobo: What is the story behind the spear, if you don’t mind my asking?

Suchindranath Aiyer: I was in Africa for five years. I had been working as a management consultant in Bangalore when I was invited to interview for a job in Nairobi. I went to enjoy the wildlife and I fell in love with the place.

I had my first accident in Kenya, actually, on the Mombasa-Nairobi highway. We had a cliff on one side and an abyss on the other, so I had to drive head-on into a huge sixteen-wheel truck or my three passengers and I would have been killed.had fabulous communion in the most unlikely of places.

RL: You spent time in Japan, correct?

SA: I belong to a Japanese spiritual organization called Toho no Hikari. Light from the East. They’re into three activities — spiritual healing, nature farming, and the promotion of the arts. Their founder, Mokichi Okada [1882–1955], was and is my guru to this day. That painting on the wall is by him.

RL: What was it that attracted you to Toho no Hikari?

SA: These people do exactly what the covenant of Brahma expects. They are the only organization I have found that pursues the covenant of Brahma. They had an office at Richmond Circle in Bangalore in 1995, however they fled India with great suspicion — they were cheated here. I followed them to Japan


The Behavioral Testing Facility was created three years ago to facilitate the development of neuroscience research at the Universidad Central del Caribe. Currently, the importance of behavioral testing is being recognized by investigators with other research interests. Based on these needs, the main goal in this proposal is to provide experimental support to the projects developed by a diverse group of scientists. The facility has two mayor components: A) the equipment infrastructure and B) the technical support division. This proposal plans to develop this facility by incorporating two consultants and expanding the experimental setup offerings with new equipment for remote behavior visualization (RBV). The specific aims proposed during the present period are: A: To improve the existing equipment and the environment necessary for new and ongoing experiments B.probably because she's just that sensitive (be it to other people, her 'sympathetic nature' or some other reason).

I don't think Eileen hears it actually, but she does sense that something's wrong far before any other neighbor.

He would have died most likely-- either from the hauntings or Walter just finally coming in like, "What the shit, Henry, I thought we had something here. Thought we were doin' this. What are you doing man, get your ass out there." and Henry would be like, "NO, YOU SUCK! I DON'T WANNA PLAY ANYMORE!" and Walter would probably just shoot him and be done with it.

There was absolutely no way for him to venture out and Walter probably wouldn't have been able to make the kills because Henry had to be there


or trauma, inflicted traumatic brain injury \[[@bib6]\] or more inclusively, "shaken impact syndrome" \[[@bib7]\]. Finally, the American Academy of Pediatrics \[[@bib8]\] and consecutively the Centers for Disease Control and Prevention (CDC) \[[@bib9]\] recommend the term abusive head trauma (AHT) based on the understanding of the mechanisms and clinical spectrum of injury associated with abusive head injury. Although shaking alone has the potential to cause neurologic damage, blunt impact or a combination of shaking and blunt impact cause significant neurologic injuries \[[@bib5],[@bib10]\].

AHT typically involves injury to the intracranial structures or skull of an infant or child younger than 5 years old as a result of violent shaking and/or blunt impact. The outcome ranges from complete recovery to significant brain damage and even death. Brain injuries are the most commonbe found in children with accidental head trauma, birth trauma, coagulopathy, and CNS infection. Retinal hemorrhages associated with accidental trauma were always mild. However, healthcare providers should not use retinal hemorrhage alone to diagnose AHT.

Skull fractures {#sec4.3}
---------------

Skull fractures occur as a result of a direct force applied to the head. AHT often be considered when the fracture is complex, diastatic (width greater than 3 mm), multiple, and non-parietal. Any of these types of skull fractures may suggest the possible existence of AHT \[[@bib41]\].

Rib fractures {#sec4.4}
-------------

Rib fractures are common in child abuse. They usually occur as the result of squeezing the infant\'s chest wall, which produces anterior-posterior compressive forces resulting in rib fractures.

The fractures are easily detected on routine chest x-ray or a skeletal survey. Accidental rib fractures are uncommon


Q:

How to attach Visual Studio to a C++ node module?

I wrote a node.js module in C++ with Visual Studio. I created the project with node-gyp configure --debug. This seems to work fine and I can compile my code and a loadable binary is created in the Debug folder. I am then able to require('./build/Debug/mymodule) this file from a server.js file and when I start the server from the command line (node server.js), the module runs. But I am struggling to figure out how to attach the Visual Studio Debugger.
According to this question it sounds like gdb is automatically attached (?), but how do I invoke my server.js with the Visual Studio debugger?
Edit: I run Visual Studio 2015 and node v4.1.2

A:

Seems like I figured it out.

Goto: Project->Properties
Open-conf F       Use the config file F instead of the default one:
                  crypto/err/openssl.ec

  -hprefix P    Prepend the filenames in generated #include <header>
                statements with prefix P. Default: 'openssl/' (without
                the quotes, naturally)

  -debug        Turn on debugging verbose output on stderr.

  -rebuild      Rebuild all header and C source files, irrespective of the


         fact if any error or function codes have been added/removed.
                Default: only update files for libraries which saw change
                         (of course, this requires '-write' as well, or no
                          files will be touched!)

  -recurse      scan a preconfigured set of directories / files for error and
     BIO_F_CTX which needs to be ignored.
# If a code doesn't exist in list compiled from headers then mark it
# with the value "X" as a place holder to give it a value later.
# Store all function and reason codes found in %ufcodes and %urcodes
# so all those unreferenced can be printed out.

foreach $file (@source) {
	# Don't parse the error source file.
	next if exists $cskip{$file};
	print STDERR "File loaded: ".$file."\r" if $debug;
	open(IN, "<$file") || die "Can't open source file $file\n";
	while(<IN>) {
		# skip obsoleted source files entirely!
		last if(/^#error\s+obsolete/);

		if(/(([A-Z0-9]+)_F_([A-Z0-9_]+))/) {
			next unless exists $csrc{$2};
			next if($1 eq "BIO_F_BUFFER_CTX");
			$ufcodes{$1} = 1;
			if(!exists $fcodes{$1}) {
				$fcodes{$1} = "X";
				$fnew{$2}++;
			}
			$notrans{$1} = 1 unless exists $ftrans{$3};
			print STDERR "Function: $1\t= $fcodes{$1} (lib: $2, name: $3)\n" if $debug;
		}
		if(/(([A-Z0-9]+)_R_[A-Z0-9_]+)/) {
			next unless exists $csrc{$2};
			$urcodes{$1} = 1;
			if(!exists $rcodes{$1}) {
				$rcodes{$1} = "X";
				$rnew{$2}++;
			}
			print STDERR "Reason: $1\t= $rcodes{$1}


made after this point may be overwritten when the script is next run.
 */
EOF
	if($static) {
		print OUT <<"EOF";
${staticloader}void ERR_load_${lib}_strings(void);

EOF
	} else {
		print OUT <<"EOF";
${staticloader}void ERR_load_${lib}_strings(void);
${staticloader}void ERR_unload_${lib}_strings(void);
${staticloader}void ERR_${lib}_error(int function, int reason, char *file, int line);
# define ${lib}err(f,r) ERR_${lib}_error((f),(r),__FILE__,__LINE__)

EOF
	}
	print OUT <<"EOF";
/* Error codes for the $lib functions. */

/* Function codes. */
EOF

	foreach $i (@function) {
		$z=48 - length($i);
		if($fcodes{$i} eq "X") {
			$fassigned{$lib} =~ m/^:([^:]*):/;
			$findcode = $1;
			if (!defined($findcode)) {
				$findcode = $fmax{$lib};
			}
			while ($fassigned{$lib} =~ m/:$findcode:/) {
				$findcode++;
			}
			$fcodes{$i} = $findcode;
			$fassigned{$lib} .= "$findcode:";
			print STDERR "New Function code $i\n" if $debug;
		}
		printf OUT "# define $i%s $fcodes{$i}\n"," " x $z;
	}

	print OUT "\n/* Reason codes. */\n";

	foreach $i (@reasons) {
		$z=48 - length($i);
		if($rcodes{$i} eq "X") {
			$rassigned{$lib} =~ m/^:([^:]*):/;
			$findcode = $1;
			if (!defined($findcode)) {
				$findcode = $rmax{$lib};
			}
			while ($rassigned{$lib} =~ m/:$findcode:/) {
				$findcode++;
			}
			$rcodes{$i} = $findcode;
			$rassigned{$lib} .= "$findcode:";
			print STDERR "New Reason code   $i\n" if $debug;
		}
		printf OUT "# define $i%s$rcodes{$i}\n"," " x $z;
	}
	print OUT <<"EOF";

#ifdef  __cplusplus
}
#endif
#endif
EOF
	close OUT;

	# Rewrite the C source file containing the error details.

	# First, read any existing reason string definitions:
	my %err_reason_strings;
	if (open(IN,"<$cfile")) {
		my $line = "";
		while (<IN>) {
			chomp;
			$_ = $line . $_;
			$line = "";
			if (/{ERR_(FUNC|REASON)\(/) {
				if (/\b(${lib}_R_\w*)\b.*\"(.*)\"/) {
					$err_reason_strings{$1} = $2;
				} elsif (/\b${lib}_F_(\w*)\b.*\"(.*)\"/) {
					if (!exists $ftrans{$1} && ($1 ne $2)) {
						print STDERR "WARNING: Mismatched function string $2\n";
						$ftrans{$1} = $2;
					}
				} else {
					$line = $_;
				}
			}
		}
		close(IN);
	}

	my $hincf;
	if($static) {
		$hfile =~ /([^\/]+)$/;
		$hincf = "<${hprefix}$1>";
	} else {
		$hincf = "\"$hfile\"";
	}

	# If static we know the error code at compile time so use it
	# in error definitions.

	if ($static)
		{
		$pack_errcode = "ERR_LIB_${lib}";
		$load_errcode = "0";
		}
	else
		{
		$pack_errcode = "0";
		$load_errcode = "ERR_LIB_${lib}";
		}

	open (OUT,">$cfile") || die "Can't open $cfile for writing";

	print OUT <<"EOF";
/* $cfile */
/* ====================================================================
 * Copyright (c) 1999-$year The OpenSSL Project.  All rights reserved.
 *
 *


The present invention relates generally to harvesting machines that use beater rods to harvest berries, fruits or other produce and, more particularly, to the drive system for moving the beater rods during harvesting.
Harvesting machines are commonly used to harvest berries, fruits, and other produce of row crops. The individual plants, such as trees, vines, or bushes, of such crops are typically arranged in rows.
Conventional harvesting machines commonly comprise a chassis or carriage that travels along the rows on wheels. In some configurations, the carriage in the shape of an inverted xe2x80x9cUxe2x80x9d and straddles one row of the crop. In other arrangements, the entire chassis moves between two crop rows.
Conventionally, harvesting machines comprise beater rods that extend radially outwardly from a rotating hub. As the harvesting machine moves alongincreases the number and diversity of students matriculating to biomedical research doctoral programs by infusing research training throughout the student undergraduate experience; 3) Establish opprtunlties for underrepresented students to enter the research career pathway late in their undergraduate careers though a biomedical research certificate program; and, 4) Work in collaboration with our pipeline/research partners to engage students eariy in mentored laboratory, clinical, and community-based participatory research training and experiences designed to enhance student and faculty engagement in biomedical research that supports matriculation to graduate programs and doctoral degrees supporting eventual biomedical and behavioral research careers. BUILD will facilitate the creation of a new curriculum, formalized extramural collaborations, and new cross disciplinary interactions to transform CSULB into a model training program for under-represesnted students in biomedical and behavioral research.


relations and romantic relationships are difficult. What is your opinion on those two themes?

To be honest, I am worried about my relationship and family relationships, but I lack initiative, I do not act on my worries. In “RPG”, we set up a game rule to push people tο take action, which is nice for people like me.

Does the concept of the Sawalong have an ulterior meaning-is it a metaphor?

I think its pronunciation does not sound so good in English. However, in Chinese, it sounds really cool, and the Sawalong is huge and only appears at the end of the tour. Furthermore, in the ending of the film, it is revealed that the boy’s end of the tour was controlled by his sister. It means that sometimes, the answersmultimedia, and other data-intensive applications use very large objects—typically hundreds of gigabytes or even terabytes. Uploading of such objects into a distributed storage system is typically done in the streaming mode by splitting the object into chunks and uploading each chunk individually. This process can impose long delays in the upload time that may be exacerbated by potential client and/or server failures. Consequently, efficient distributed object uploading in the streaming mode that provides consistency guarantees is becoming increasingly important for the storage industry being driven by the needs of large-scale systems that allow clients to connect to any cluster available at a time.


University of North Carolina center for accurately describing the impact of their policies. In 2012 John Allison, a former head of the Cato Institute, said that spending money and energy to influence curricula was “clearly in our shareholders’ long-term best interest.” Few pundits have criticized these arrangements, revealing their implicit belief that the proper way to influence the national discourse is through the exercise of wealth, rather than protest.

Opposition To “Political Correctness” Is Rooted in Bigotry

What is commonly referred to “political correctness” is in fact an attitude of cultural inclusion that broadens the intellectual experience. And those who dislike political correctness often disguise the extent to which their attitudes are tied to racial animus.

The 2016 American National Election Studies pilot survey, fielded during the primary elections, included theJanuary. In his 2015 opus on political correctness, Chait wrote: “American political correctness has obviously never perpetrated the brutality of a communist government, but it has also never acquired the powers that come with full control of the machinery of the state.” Throughout American history, white supremacists have executed untold brutality and billionaires have worked to silence dissent — and they now control the full machinery of the state. And yet, it’s political correctness we’re supposed to be worried about?

Do the correct thing. Subscribe to our amazing newsletter. Subscribe Nice email address!


shown for 2 representative WTs identifies hypermethylation of multiple gene promoters across a domain spanning 800 kb on chromosome 5q31.3 (red box). (B) The MeDIP-chip profile of *PCDHA@*, *PCDHB@* and *PCDHG@* in a representative WT. A minority of genes escaping hypermethylation are indicated (black arrowheads). (C) DNA methylation assayed using COBRA. Percentage methylation was analysed by gel densitometry for each gene, and is represented by horizontal bars (black  =  percentage methylated, white  =  percentage unmethylated). Data from 6 normal tissues (4 fetal kidneys \[FK\], postnatal kidney \[NK\] and fetal brain \[FB\]) and 9 Wilms\' tumours are shown. Non-*PCDH* genes flanking the domain and between *PCDHB@* and *PCDHG@* are also shown. (D) Unsupervised hierarchical clustering of COBRA methylation data from normal and tumour tissues (T), HEK293 and WiT49 cellexpression of *Pcdhg@* encoded proteins (γ-PCDHs) immunohistochemically in postnatal day 1 murine kidney ([Figure 4D](#pgen-1000745-g004){ref-type="fig"}). High expression was evident in the blastemal cells, with decreasing and more variable expression apparent in tubules and parietal epithelia. Subcellular staining was variable and included nuclear staining, which is consistent with a role for the γ-PCDH intracellular domain in gene regulation [@pgen.1000745-Haas1],[@pgen.1000745-Hambsch1]. Expression in the ureteric bud and visceral epithelia was low or absent. Thus γ-PCDHs proteins are evident in the murine equivalent of the presumptive multipotent cell of origin for WT. This is consistent with PCDHs having a role in kidney development and Wilms\' tumorigenesis.

Modulation of canonical Wnt signalling by PCDHs {#s2f}
-----------------------------------------------

Little is known about PCDH cellular functions, but a member of the PCDH superfamily, PCDH-PC, was previously shown to positively


ng/ml prostaglandin, 4 ng/ml tri-iodo-l-thyronine, 10 ng/ml holo-transferrin. Epithelial differentiation was induced over 5 days with 50 ng/ml leukemia inhibitory factor (Lif, Chemicon), 20 ng/ml transforming growth factor α (Tgfα, R&D Systems) and 50 ng/ml fibroblast growth factor (Fgf2, R&D Systems) [@pgen.1000745-SchmidtOtt1], after which RNA was extracted with Tri reagent (Sigma).

For PCDH over-expression studies, cDNAs were obtained by RT-PCR from fetal kidney RNA and cloned into pCDNA3.1/Zeo (Invitrogen). For β-catenin/TCF reporter assays, 10^5^ cells/well were seeded in 24-well plates and transfected with 400 ng of expression constructs together with 100 ng Super 8xTOPFLASH or Super 8xFOPFLASH using Fugene 6 (Roche), and assayed for luciferase as described above. For colony formation assays, 2.5×10^5^ HCT116 and WiT49 cells were transfected with 1 ug of expression plasmids in 6-well plates andK Malik. Analyzed the data: AR Dallosso, AL Hancock, KW Brown, K Malik. Contributed reagents/materials/analysis tools: J Barasch, R Vuononvirta, K Pritchard-Jones, B Royer-Pokora, SB Lee, M Frank, A Ward. Wrote the paper: K Malik. Devised array analysis: K Moorwood, KW Brown.


Western District of Texas

Before ELROD, SOUTHWICK, and GRAVES, Circuit Judges.
LESLIE H. SOUTHWICK, Circuit Judge:
      The plaintiffs challenge a provision in the Texas Administrative Code
regulating advertising in the field of dentistry. The district court held that the
provision violated the plaintiffs’ First Amendment right to engage in
commercial speech.     It therefore enjoined enforcement of the provision as
applied to the plaintiffs. The defendants appealed. We AFFIRM.

              FACTUAL AND PROCEDURAL BACKGROUND
      Texas law prohibits dentists from advertising as specialists in areas that
the American Dental Association (“ADA”) does not recognized as specialties.
See TEX. ADMIN. CODE § 108.54. The plaintiffs seek to enjoin enforcement of
Section 108.54, as they    Page: 7   Date Filed: 06/19/2017

                                  No. 16-50157
      The parties do not dispute that the relevant speech in this case concerns
lawful activity.   Texas law permits the individual plaintiffs to limit their
practice to the fields of implant dentistry, dental anesthesiology, oral medicine,
and orofacial pain. We agree, then, that advertising as a specialist in one of
these practice areas concerns lawful activity.
      The parties disagree as to whether the speech would be misleading or
just potentially misleading. The distinction is important. “States


Peel, 496 U.S. at 105. The problem here is the absence of any
group imprimatur behind the label “specialist.”           Nonetheless, the term
“specialist” is not rendered devoid of intrinsic meaning, and thereby inherently
misleading, simply because the organization responsible for conferring
specialist credentials on a particular dentist is not identified in the
advertisement. See Ibanez v. Florida Dep’t of Bus. & Prof’l Regulation, Bd. of
Accountancy, 512 U.S. 136, 145 & n.9 (1994). Whether the absence of that
information contributes to the potentially misleading character of the speech
is a separate question.
      Moreover, there is no evidence that the term “specialist” has been or will
be used in a way that is distinct from its ordinary meaning. In one appeal, we
held that           11
    Case: 16-50157    Document: 00514039074        Page: 12   Date Filed: 06/19/2017

                                  No. 16-50157
“empirical data, studies, and anecdotal evidence,” or “‘history, consensus, and
simple common sense.’” See Pub. Citizen, 632 F.3d at 221 (quoting Florida Bar
v. Went For It, Inc., 515 U.S. 618, 628 (1995)).
      The Board says it is common sense that Section 108.54 advances the
interest in establishing a uniform standard for specialization and allows
consumers to


experiences of
the Board members add little to the Board’s argument, and the Borgner
surveys hardly bolster its position. The Borgner surveys are not in the record
and the district court could not “mak[e] an independent evaluation of their
applicability to the facts before it . . . .” Moreover, those surveys were provided
in support of a different regulatory regime that permitted “advertisement of
an implant dentistry specialty” and membership in a credentialing
organization “so long as these statements are accompanied by the appropriate
disclaimers.” Id. at 1210. Doubt has also been raised as to the validity of the
surveys. See id. at 1217 n.5 (Hill, J., dissenting); see also Borgner v. Florida
Bd. of Dentistry, 123 S. Ct. 688, 689 (2002) (Thomas, J. & Ginsburg, J.,
dissenting from denial of certiorari).
      Discovery Network, Inc., 507 U.S. 410, 417 n.13 (1993)).
The cost of the restriction must be “carefully calculated,” and the Board “must
affirmatively establish the reasonable fit . . . require[d].” Fox, 492 U.S. at 480.
      Section 108.54 completely prohibits the plaintiffs from advertising as
specialists in their fields solely because the ADA has not recognized their
practice areas as specialties. The Board has not justified Section 108.54 with
argument or evidence. Without more in the record, we find an improper fit
between the means and the objective.
      The Board has not suggested it considered less-burdensome alternatives.
To the extent that advertising as a specialist is potentially misleading, “a State
might consider . . . requiring a disclaimer about the certifying organizations or
the standards of a


(the “Board”). Academy brought a facial and as-
applied constitutional challenge against the Board arguing that Rule 108.54,
which regulates specialty advertising for dentists, unconstitutionally infringes
on commercial speech protected by the First Amendment.
      The district court partially granted both parties’ cross-motions for
summary judgment. Academy was granted summary judgment on its First
Amendment claim, invalidating the ordinance as applied to Academy. The
Board was granted summary judgment on Academy’s equal protection and due
process claims. The Board appeals the First Amendment claim. Academy
failed to file a cross-appeal, but then attempts to revive a Fourteenth
Amendment due process claim in the appellees’ brief.
      As the majority correctly states, we apply the four-part test from Central
Hudson Gas & Elec. Corp. v. Pub. Serv. Comm’n of New York,543 (1993) (regulation must advance
      substantial state interest in a “direct and material way” and be in
      “reasonable proportion to the interests served”); In re R.M.J., 455
      U.S., at 203, 102 S.Ct., at 937 (State can regulate commercial

                                       22
    Case: 16-50157    Document: 00514039074       Page: 23   Date Filed: 06/19/2017


   (5) Periodontics;
         (6) Prosthodontics;
         (7) Dental Public Health;
         (8) Oral and Maxillofacial Pathology; and
         (9) Oral and Maxillofacial Radiology.
  (c) A dentist who wishes to advertise as a specialist or a multiple-
  specialist in one or more recognized specialty areas under
  subsection (a)(1) and (2) and subsection (b)(1)-(9) of this section
  shall meet the criteria in one or more of the following categories:
         (1) Educationally qualified is a dentist who has successfully
         completedan educational program of two or more years in a
         specialty area accredited by the Commission on Dental
         Accreditation of the American Dental Association, as
         specified by the Council on Dental Education of the
         American Dental Association.
         (2) Board certified is a dentist who has met the requirements
         of a specialty board referenced in subsection (a)(1) and (2) of
         this section, and who has received a certificate from the


anti-de Sitter vacuum. While such multi-center solutions remain elusive, they may formally be obtained by sending $t\to it$ in the de Sitter metric, (\[eq:dsm\]). Alternatively, this Wick rotation could be avoided by instead taking an imaginary coupling $g$ [@london]. Of course, neither of these possibilities are entirely satisfactory. But nevertheless this approach provides a partial solution to the problem of constructing multi-center anti-de Sitter black holes. Furthermore, as many investigations of the AdS/CFT conjecture have in fact been performed in Euclidean space, it is perhaps not unreasonable after all to focus on the Wick rotated theory (although in the present case, this Wick rotation yields a pure imaginary gauge potential).

The multi-center solutions of [@kt; @london] have been constructed in the context of a cosmological Einstein/Maxwell theory. As showntheory. Finally, it remains an open issue to construct true multi-centered solutions of the gauged supergravity theory without resorting to any Wick rotation or use of an imaginary coupling.

Acknowledgments {#acknowledgments .unnumbered}
===============

We wish to thank F. Dowker for clarifying the issue of having the gauge potential become imaginary in the Wick rotated theory. JTL wishes to thank the Center for Advanced Mathematical Sciences (CAMS) at the American University of Beirut, where part of this work was performed. This research was supported in part by DOE Grant DE-FG02-95ER40899 Task G.

[99]{}

K. Behrndt, A. H. Chamseddine and W. A. Sabra, [*BPS black holes in $N=2$ five dimensional AdS supergravity*]{}, Phys. Lett. [**B442**]{} (1998) 97 \[hep-th/9807187\].

K. Behrndt, M. Cvetič and W. A. Sabra, [*Non-extreme black holes of five dimensional $N=2$ AdS supergravity*]{}, Nucl. Phys. [**B553**]{} (1999) 317 \[hep-th/9810227\].

D. Kastor and J. Traschen, [*Cosmological multi-black hole


Jacques Rousseau on UCT’s Disinvitation of Flemming Rose

17 Aug 2016

This is one in a series of articles responding to UCT’s decision to rescind an invitation to Danish journalist and writer, Flemming Rose, to give the TB Davie lecture on Academic Freedom. PEN SA President Margie Orford spoke about the matter here and called for responses, all of which can be found here.

By Jacques Rousseau

Subsequent to the decision by the University of Cape Town Executive to revoke the invitation extended to Flemming Rose, much public comment has focused on Mr Rose as being a controversial speaker. The fact that he is controversial cannot be denied, but what concerns me – and should concern us all – is that some of those who support his dis-invitation are confusing arguments aboutwhether he should have been invited in the first place with arguments for dis-inviting him.

Second, some arguments regarding whether he was an appropriate invitee or not depend on a false, or at least caricatured, impression of his views and the possible content of his talk.

Before I address these issues, it is true that the mere fact that the public perception of Mr Rose is of him being a provocateur, who is furthermore either insensitive to offending Muslims – or, according to some, downright Islamophobic – lends weight to the Executive’s decision.

Whether these perceptions are accurate or not is one issue, but an entirely separate issue is that of the extent to which those perceptions could have been exploited by those who might have wished to disrupt the TB


can be premised on an uninformed and simplistic version of the dilemma being faced.

To return to my initial points, starting with the matter of whether Mr Rose should have been invited in the first instance. The Academic Freedom Committee comprises 13 members, who receive nominations from the university community, and select a speaker from those nominated.

In March 2015, when the decision to invite Mr Rose was taken, it was in part because of threats to education posed by ISIS and Boko Haram, as well as emerging debates on visual representation (the Rhodes statue), that the committee considered him to be the strongest candidate of those nominated.

It would also be an error to view the 2016 invitee in isolation, rather than considering the history of the TB Davie lectureif we didn’t deserve it. You see, the thing is, the woke millennial doesn’t know how to rebel. And that’s the fault of their boomer and Gen X parents who were so obsessed with keeping them safe. Millennials grew up without barely scraping a knee, and so any discomfort they feel seems to cause them PTSD. Perhaps the psychic trauma of a bad date is what leads them to open up boxes at Duane Reade?

Perhaps one day soon, we will tire of the tepid, shallow pool of self-expression that we have been wading in. Perhaps the overwhelming banality of modern culture will soon lead us transgress by turning back to art, literacy, and self-improvement.

We see glimpses of it in the rise of the independent creator on YouTube, the


districts of roughly equal population and that the County's desire to preserve the integrity of town boundaries could not override that constitutional requirement.   Plaintiffs contended that weighted voting was insufficient to meet this standard in light of the Supreme Court's decision in New York City Board of Estimate v. Morris, 489 U.S. 688, 109 S.Ct. 1433, 103 L.Ed.2d 717 (1989) ("Morris II "), aff'g 831 F.2d 384 (2d Cir.1987) ("Morris I ").   Plaintiffs also contended that weighted voting was insufficient to assure them equal representation because, given the Supervisors' equal ability to participate in, inter alia, floor debates and committee work, Board members from less populous towns had disproportionate ability to influence County legislation.

7
The Board opposed summary judgment, contending, inter alia, that Delaware's presentVoters, we rejected a contention that weighted voting was per se unconstitutional, based on the Supreme Court's action in an appeal from the decision of the New York Court of Appeals, upholding a weighted-voting system, in Franklin v. Krause, 32 N.Y.2d 234, 344 N.Y.S.2d 885, 298 N.E.2d 68 (1973), appeal dismissed, 415 U.S. 904, 94 S.Ct. 1397, 39 L.Ed.2d 461 (1974).   We noted that in Franklin, the first question presented to the Supreme Court by the appellants was " '[w]hether weighted voting is unconstitutional per se as a plan of permanent apportionment for a unicameral, County legislative body having general governmental powers.' "  League of Women Voters, 737 F.2d at 164 (quoting appellants' Jurisdictional Statement).   The Supreme Court dismissed the Franklin appeal for


1449, 1458, 12 L.Ed.2d 620 (1964) ("[T]he problem does not lend itself to any such uniform formula, and it is neither practicable nor desirable to establish rigid mathematical standards for evaluating the constitutional validity of a state legislative apportionment scheme.").   In League of Women Voters, we endorsed a method of calculating deviation from mean population that compared the percent of total population represented by a given local official to the percent of weighted votes allocated to that official, noting that such a measure was appropriate for "a complex weighted voting system" that allowed for the flexibility necessary to local governance.  737 F.2d at 171.   In that case, we concluded that the resulting maximum deviation of 7.3% comported with the principle of population equalitysecond aim is to evaluate the possibility that differences in muscles' responses to vasodilator agents could be attributed to differences in adrenergic, muscarinic or purinergic influences on their feed vessels. Myogenic tension and tension development in response to agonists and blockers specific to these receptors will be measured in vitro using larger vessel techniques. Endothelium will be removed mechanically in half of the vessels and its presence will be verified in the other half. The dose-response characteristics of the soleus muscle's feed vessel and the extensor digitorum longus' feed vessel are compared using paired T analysis. The results of this investigation will enhance our understanding of both the functional significance of feed vessel heterogeneity and its role in the limitations of skeletal muscle performance.


at the Israeli Foreign Ministry. Also, for one who claims to be an American citizen he fails to make any legitimate case that his own countrymen are in any way threatened by Iran or the Palestinians. He does cite Congressional support for recent Israeli war crimes but as everyone inside the beltway knows, that is low hanging fruit that can be plucked by anyone who cheerleads for Israel.

Indeed Boteach’s passion for another country blinds him to what US interests actually might be. He also chooses to ignore the fact that even if one is uncritically partisan it is indisputable that the Israelis have not exactly been innocents amidst all the death and destruction, that indiscriminate shelling and bombing of Gaza have killed more than 2,000, one quarter ofconversation with former player Amy Alcott helped.

"She told me that's never going to go away, that feeling of wanting to compete," Daly-Donofrio said. "I was happy to hear that. But the reality is, your priorities change. ... I miss the competition, but I don't miss the preparation. I don't miss all the practice you have to go through and I don't miss the mental strain.

"I think when you stop playing you only remember the times you played well. You don't remember the times you struggled as much. It's tough at times because that was your identity. The sport is your drug."

But Daly-Donofrio, who earned $1.1 million as a professional, said her new job has plenty of pluses. She believes her knowledge of the city and the course will


control signals from the computers and provides the control signals to the signal generation equipment in the proper format which allows the rf antenna to simulate a target. Typical of these prior art computer systems is the model CDC6600 computer provided by Computer Development Corporation.
            public void characters(char ch[], int start, int length) throws SAXException {

            }
         };
        saxParser.parse(thexml, handler);
        } catch (SAXException e) {
            e.printStackTrace();
        } catch (IOException e) {
            Log.e("e", "e",


read.
What you might want to do instead is to create an InputSource from a StringReader like this:
InputSource source = new InputSource(new StringReader(thexml));
saxParser.parse(source, handler);

A:

SAXParser's parse method expects a file name or URI as first argument, not an XML file read into a string.

order to receive additional KKN tokens, if you believe in our project, you can promote us by posting promotional materials regarding Kakushin ICO throughout the web and on social media.
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              j CATHY STLUSK, CLER!<
                                   COURT OF APPEALS NO. 12-12-00118-CR

THE STATE OF TEXAS,

TO THE 145TH DISTRICT COURT OF NACOGDOCHES COUNTY GREETINGS:

       Before our COURT OF CRIMINAL APPEALS, on APRIL 22, 2015, the cause upon an Application for

Writ of Habeas Corpus styled;

                             EX PARTE JAMARIOS LECHRISTOPHER CANTON

CCRA NO./*!
 * Bootstrap v3.1.1 (http://getbootstrap.com)
 * Copyright 2011-2014 Twitter, Inc.
 * Licensed under MIT (https://github.com/twbs/bootstrap/blob/master/LICENSE)
 */

.btn-default,
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Such a difficulty is absent when the perturbation parameters space or time variables $x$ and $t$. Indeed the methods of [@TV_det] and [@TV_param] are applied in this work and amongst the surprises which allow the methods to apply is a collection of explicit formulae for dependence in $\mu$ summarized in Lemmas 3.2-3.4.

Essential mathematical difficulties are encountered in the solution of the initial value problem and in general and and in particular.

1.  The calculation of the scattering data at $t=0$ is extremely delicate as seen from the work of Klaus and Shaw [@KlausShaw].

2.  The linearizing Zakharov-Shabat eigenvalue problem [@ZS] is [*not selfadjoint*]{}. This is in contrast to the selfadjointness of the initial value problem for the small-dispersion Korteweg-de Vries (KdV) equation, in which a systematic steepest descentthat emanate from the break-point. The eventual breaking of this new phase, the so-called [**second break**]{}. The mechanism of the second break is fundamentally different from the one of the first.

As stated above, the [**analytic description of $n$-phase waves**]{} [@Belo] is in terms of an $n$-phase Riemann theta function. This is an $n$-fold Fourier series obtained by summing exp{$2\pi i{\bf z}\cdot{\bf m}+\pi i(B{\bf m},{\bf m})\} $ over the multi-integer ${\bf m}$. $B$ is an $n\times n$ matrix with positive definite imaginary part that gives the series exponential quadratic convergence. In the case of NLS waves, the matrix $B$ arises from periods of the Riemann surface of the radical $$\label{radical}
R(z)=\left(\prod_{i=0}^{2n+1}(z-\alpha_i)\right)^\frac{1}{2}, \ \ \ \ \ \mbox{where} \ \ \  {\alpha}_{2j+1}=\overline{\alpha}_{2j};$$ the elements of $B$ are linear combinations of


scattering states and the bound states in time and is again a $2\times 2$ linear ODE system. The holding of the NLS equation guarantees that this evolution involves the action of a time dependent unitary operator. As a result, the spectrum of the first Lax operator remains constant in time and the scattering data evolve in time through multiplication by simple explicit exponential propagators. The continuous spectrum contributes [**radiation**]{} to the solution of NLS. The bound states contribute [**solitons**]{}.

Zakharov and Shabat [@ZS] developed the inverse scattering procedure for deriving $q(x,t)$ at any $(x,t)$ given the scattering data at $t=0$. In the modern approach initiated by Shabat [@Shabat], the procedure is recast into a [**matrix Riemann-Hilbert problem**]{} (RHP) for a $2\times2$ matrix on the complex plane of the spectralthe left/right of the contour. The $2\times2$ matrix $V=V(z,x,t,{\varepsilon})$, defined on the jump contour and referred to as the [**jump matrix**]{}, is nonsingular and encodes the scattering data (see below). The space-time variables $x,t$ (and the semiclassical parameter $\varepsilon$) are parameters in the problem.

The solution to is given by the simple formula $$q(x,t,{\varepsilon})=\lim_{z\to\infty}zm_{12}(z,x,t,{\varepsilon}).$$ The results and the calculations of this study are in the asymptotic limit of the semiclassical parameter ${\varepsilon}\to 0$.

Background: The semiclassical limit ${\varepsilon}\to 0$
--------------------------------------------------------

The Riemann-Hilbert approach is a major tool in the asymptotic analysis of integrable systems as established with the discovery of the steepest descent method [@DZ1; @DZ2] and its extension through the $g$-function mechanism [@DVZ1; @TVZzero]. The asymptotic methods via the RHP approach also apply to orthogonal polynomial asymptotics [@Deift_book; @DKMVZ_strong], and to


leave to amend.

DISCUSSION
I. DID THE TRIAL COURT ERR IN GRANTING FORD'S MOTION FOR SUMMARY JUDGMENT?
¶ 12. In reviewing a lower court's grant of summary judgment, this Court employs a de novo standard of review. Anglado v. Leaf River Forest Prods., 716 So.2d 543, 547(13) (Miss.1998). Summary judgment "shall be rendered forthwith if the pleadings, depositions, answers to interrogatories, and admissions on file, together with any affidavits, if any, show that there is no genuine issue as to any material fact and that the moving party is entitled to judgment as a matter of law." M.R.C.P. 56(c). We will consider all of the evidence before the lower court in the light most favorable to the non-moving party. Palmer v. Anderson Infirmary Benevolent Ass'n, 656 So.2d 790, 794 (Miss.1995). Theabs(L[n-1] - L[n]))
        if m < (.5e-9):
            print(n, "\n")
            x = max(abs(L[n-2] - L[n-1]), abs(L[n-1] - L[n]))
            print(x, "\n")
            print(L[n], "\n")
            break
        break

and the exact error message is
Traceback (most recent call last):
  File "<pyshell#44>", line 1, in <module>
    NewtonRaphson2()
  File "C:/Python34/nmhw3.py", line 28, in NewtonRaphson2
    m = (max(abs(L[n-2] - L[n-1])),


Bayesiaanse binomiaaltoets
===

Met de bayesiaanse binomiaaltoets kan worden getoetst of de proportie van een dichotome variabele gelijk is aan een toetswaarde (aangenomen populatie waarde).

### Assumpties
- De variabele is dichotoom.
- Observaties moeten onafhankelijk zijn.

### Invoer
---------

- Toetswaarde: De proportie van de variabele onder de nulhypothese. De standaardwaarde is 0.5.

#### Hypothesen
- *≠ Toets waarde*: Tweezijdige alternatieve hypothese dat de proportie niet gelijk is aan de toetswaarde.
- *> Toets waarde*: Eenzijdige alternatieve hypothese dat de proportie hoger is dan de toetswaarde.
- *< Toets waarde*: Eenzijdige alternatieve hypothese dat de proportie lager is dan de toetswaarde.

#### Bayes factor
- BF10: Als u deze optie selecteert geeft de Bayes factor bewijs voor de alternatieve hypothese ten opzichte van de nul hypothese. Dit is de standaardoptie.
- BF01: Als u deze optie selecteert geeft deconsequences of any virus introduction" (9/8).

Immunizing Children Against Some Pneumococcal Virus Strains May Make Them More Vulnerable To Other Strains, Study Finds

A study published Wednesday in the Journal of the American Medical Association finds that children who were vaccinated with Pfizer's Prevnar 7 pneumococcal vaccine were "more likely than unvaccinated children to develop a strain of the disease known as 19A, which is not covered by the shot," Reuters reports. The findings suggest "that while vaccinating children ... dramatically reduces the burden of pneumococcal disease caused by the strains targeted by the vaccine, constant surveillance is needed to check for new strains, or serotypes" of the virus, the news service writes. "Pneumococcal disease is one of the world's biggest killers of children, claiming up to 1.6 million lives


Tag Archives: mrsplayfair

Sticking with our recent "100 years ago" theme, today we post an image of the council members of Fianna Éireann. The catalogue lists this as "1915" with a front row (left to right) of Patrick Holohan, Michael Lonergan and Con Colbert. And a back row (left to right) of Garry Holohan and Padraig Ryan.

Con Colbert (1888-1916) would be known to some – not least for his execution after the Easter Rising. Garry Holohan (1894-1967) also took part in events the year after this photo was taken – and may have fired some of the first shots of the 1916 Rising in the raid on the Phoenix Park Magazine Fort. But we wondered if anyone had information on the others.

The biggest story of the day is thatthe Easter Rising. Garry Holohan (1894-1967) also took part in events the year after this photo was taken – and may have fired some of the first shots of the 1916 Rising in the raid on the Phoenix Park Magazine Fort. But we wondered if anyone had information on the others.

The biggest story of the day is that the date is probably not 1915. While this somewhat undermines our planned "100 Years Ago" theme, it is great to have community input on the accuracy of the catalogue entries!

In reviewing the date, the community has pointed out that Lonergan had gone to the USA in Spring 1914 – so if Lonergan is indeed pictured, this would have to be 1914. Or earlier. Also noted was that the shirts that


Rich"--foment Culture War in society to distract and cover their real economic motives. Culture War, Class War explores the resulting cultural divide--how it was instigated and kept alive for fifty years in America by certain elite powers and how and why they choose to benefit while tearing families in two and keeping America paralyzed.---
abstract: 'We study the Dirichlet problem for the non-local diffusion equation $u_t=\int\{u(x+z,t)-u(x,t)\}{\,\mathrm{d}\mu}(z)$, where $\mu$ is a $L^1$ function and $``u=\varphi$ on $\partial\Omega\times(0,\infty)$” has to be understood in a non-classical sense. We prove existence and uniqueness results of solutions in this setting. Moreover, we prove that our solutions coincide with those obtained through the standard “vanishing viscosity method”, but show that a boundary layer occurs: the solution does not take the boundary data in the classical sense on $\partial\Omega$, a phenomenon related to the non-local character of the equation. Finally, we show that in a bounded domain, some regularization may occur, contrary to what happens in the whole space.'
author:
- 'Emmanuel Chasseigne${}^1$'
date:
-
-
title: The Dirichlet problem for some nonlocal diffusion equations
---

**Keywords:** integro-differential equations ; Dirichlet problem ; Lévy operators


; general nonlocal operators.

**Mathematics Subject Classification:** 47G20, 35D05, 35D10 35B05, 35B50, 35B65;

Introduction
============

In this paper we investigate a suitable notion of Dirichlet Problems in a bounded set $\Omega\subset{{\mathbb{R}}}^n$ for a class of non-local equations, starting from remarks and ideas developed in [@CCR] to cover a more general framework.

To begin with, let us consider our model equation posed in the whole space ${{\mathbb{R}}}^n$ : $$\label{eq0}\frac{\partial u}{\partial t}(x,t)=\int_{{{\mathbb{R}}}^n}\big\{u(x+z,t)-u(x,t)\big\}{\,\mathrm{d}\mu}(z)\,,$$ where $\mu\in\mathcal{M}({{\mathbb{R}}}^n)$ is a finite measure. Such non-local diffusion operators arise in various problems like diffusion of population (see [@CCR] and the references therein for more on this topic), Lévy processes [@bertoin; @CV; @woyczynski], fractional Laplace diffusion [@silvestre06], and more generally, integro-differential pde’s (see [@Al] and the references therein). Note that in the fractional Laplacian case, $\mu(z)=|z|^{-N-\lambda}$ with $0<\lambda<2$, a case in whichonly to investigate the term $$\int_0^{t_n}\int_{\{(x_n+z)\in\Omega\}} u(x_n+z,s){\,\mathrm{d}\mu}(z)\mathrm{d}s+\int_0^{t_n}\int_{\{(x_n+z)\in\partial^\mu\Omega\}} \varphi(x_n+z,s){\,\mathrm{d}\mu}(z)\mathrm{d}s\,.$$ To treat both terms at the same time, consider the extension $\tilde{u}$ defined in . Then $\tilde{u}(x_n+z,s)\to \tilde{u}(x+z,s)$ for any $z$ such that $(z+x)\not\in\partial\Omega$ (recall that $u$ and $\varphi$ are continuous on either side of the boundary of $\Omega$), so that $\tilde{u}(x_n+\cdot)\to \tilde{u}(x+\cdot)$ almost everywhere in ${{\mathbb{R}}}^n$ and $\tilde{u}$ is uniformly bounded. By dominated convergence we get that $$\int_0^{t_n} \tilde{u}(x_n+z)d\mu(z)\to\int_0^t \tilde{u}(x+z)d\mu(z)\,,$$ which proves that $T_{u_0}(u)$ is continuous in all $[0,t_0]\times\bar\Omega$.

Now it is easy to check that (recall again that $\mu({{\mathbb{R}}}^n)=1$) $$\sup_{\Omega\times[0,t_0]}|T_{u_0}(v)-T_{u_0}(w)|\le 2t_0\cdot\sup_{\Omega\times[0,t_0]}|v-w|\,,$$ which implies that $T_{u_0}$ is a strict contraction in $X_{t_0}$ provided $t_0<1/2$. Hence in this case, we may use Banach’s fixed point theorem in $X_{t_0}$ to obtain a unique solution of $u=T_{u_0}(u)$ in $X_{t_0}$. Once a solution is


as we already did in the previous section, we can pass to the limit as $x$ goes to the boundary to conclude that the equation is satisfied in $\bar\Omega\times(0,\infty)$. Moreover, $u_*$ can be extended to get a solution $u\in\mathrm{C}(\bar\Omega\times[0,\infty))$, so that $u$ is the unique solution of the problem (by Theorem \[thmexun\]).

Let us now prove that the limit holds pointwise : take $T>0$ fixed. Since $u_{{\varepsilon}_n}\to u$ in $L^\infty$-weak$\star$, we can always assume that the limit also holds in $L^2$-weak. Let us make some energy estimates in $L^2$ for the solution : since $u_{{\varepsilon}_n}=0$ on the boundary, $$\int_\Omega |u_{{\varepsilon}_n}|^2(t)+{\varepsilon}_n\int_0^T\int_\Omega|Du_{{\varepsilon}_n}|^2=\int_\Omega |u_0|^2(t)+\int_0^T\int_\Omega K_0(u_{{\varepsilon}_n})u_{{\varepsilon}_n}\,,$$ so that in the limit we get $$\int_\Omega |u_*|^2\le\int_\Omega |u_0|^2+\int_0^T\int_\Omega K_0(u_*)u_*\,.$$ But since this inequality is in fact an equality (obtained by multipling the limit equation byIndeed, if $\mu$ is too much off-centered, then the operator will not see anything in $\Omega$ itself: consider for instance $\Omega=]-10;+10[$, $\varphi=0$ and let $\mu$ be the caracteristic function of the set $]-1,0[$. If $u(0)\in\mathrm{C}_0(\Omega)$, it will remain compactly supported on the left for any $t>0$.

**5.** We showed a kind of regularizing effect in the case of bounded domains, provided the measure $\mu$ satfisfies $\lambda(\eta)<1$. Let us consider the case $\Omega=]-1;1[$ and let us give an example of a measure $\mu$ satisfying this property : $\mu(z)=ce^{-|z|^2}$, where $c>0$ is such that $\mu({{\mathbb{R}}})=1$. Then clearly, since $\widetilde{\Omega}=]-2;2[$, $\lambda(\eta)\le 1-\int_{-2}^{+2}{\,\mathrm{d}\mu}(z)<1$. One can also have a good estimate of the rate in the exponential decay. Now if $\mu(z)$ is the characteristic function of the set $]-1/2;1/2[$, we have clearly that for


ware have been found in the area, and Roman pottery was found in the vicinity of the clay pits at Prospect Park Brick Works.
Later inhabitation of Southcote was discovered at Anslow's Cottages south of the Kennet, where excavation suggests that a Bronze Age waterfront was made on a branch of the river. A 1991 report by the Historic Buildings and Monuments Commission for England—now known as English Heritage—detailed the discovery of fragments of twined basketry at Anslow's Cottages, showing that eel or fish traps were used on the river near Southcote. Archaeological findings of timber structures adjacent to the trap suggest that it dated from the eight or ninth century. Later discoveries, made in the 1980s during gravel extraction in the area, also uncovered evidence of a landingremained untended until its discovery in 2012 by Jean Spinosa.

No records of any sales are recorded in the online databases for any Cassady material, let alone for material of this literary consequence

Ginsberg later had no memory of giving the Joan Anderson Letter to Stern, and when Emerson closed the Golden Goose Press the letter was packed further into obscurity. It may have been lost for ever had not John ‘Jack’ Spinosa, Emerson’s officemate at 40 Gold Street in San Francisco, insisted on preserving the press’s archives when they were forced to vacate their rental space.

Spinosa recognized that literary history was preserved in those files, and saved them from being thrown away as Emerson cleared the office. The boxes remained with Spinosa and his wife Kathleen Cohan until after


This specification relates to determining a resource's reachability score.
The Internet provides access to a wide variety of resources, including web pages, images, text documents, and multimedia content. Search engines identify resources in response to a query including one or more search terms or phrases by returning search results that link to the identified resources. The search results are typically ordered for viewing according to scores assigned to the search results by a scoring function. The scoring function ranks the search results according to various signals including, for example, the relevance of the resources to the query and measures of quality of the resources.you choose to do business with this business, please let the business know that you contacted BBB for a BBB Business Profile.

As a matter of policy, BBB does not endorse any product, service or business.


messages of solidarity and backing poured in from around the globe killed and injured in the deplorable wrongdoing, as did appreciation for the individuals who had gotten away. Adding to the reverberating theme were individuals from the Indian cricketing network, which included present and previous players, specialists and others. They incorporated their voices in the judgment of the assault, just as their help for the Bangladesh group.

Bangladeshi writer Mohammad Isam, in a tweet, announced that the whole Bangladesh cricket group were among the individuals who get away from the mosque close Hagley.

The Bangladesh Cricket Team's legitimate Twitter handle additionally gave a refresh, guaranteeing the open that all colleagues were sheltered, expressing, All individuals from are securely back in the inn following the occurrence.

The handle likewise declared the jointthe stress conditions \[[@pone.0225899.ref033]\]. One way in which phytohormones influence gene expression is via small RNAs including microRNAs (miRNAs), which suppress gene activity by increasing transcript degradation and inhibiting translation \[[@pone.0225899.ref034]\], and heterochromatic small RNAs (hc-siRNAs), which remodel DNA methylation patterns within the promoters of target genes \[[@pone.0225899.ref035]\]. Both miRNAs \[[@pone.0225899.ref036]\] and hc-siRNAs \[[@pone.0225899.ref037]\] have been implicated in the drought response of cereals. In particular, 24-nucleotide hc-siRNAs have been identified that are present in barley caryopses subject to terminal drought stress but absent in control caryopses grown under normal conditions \[[@pone.0225899.ref037]\]. The most abundant of these hc-siRNAs was homologous to a region within the promoter of the barley *HvCKX2*.*1* gene, this promoter also containing a binding site for a second, less abundant member of the drought-specific hc-siRNA set.


a single intact product (amp1+2 primers: forward `5´–GAGGGAGTACAGTGTATGCGTATT–3´`, reverse `5´–TGATCGACGTCAGACTCACC–3´`, 1321 bp, 65°C). PCRs were carried out in a LightCycler480 (Roche) in 20 μl reaction volumes comprising 100 ng DNA extract, 1× SensiFAST SYBR No-ROX PCR master mix (Bioline), 100 nM forward primer, 100 nM reverse primer and PCR grade water. Cycling parameters were: 95°C for 5 min; followed by 35 cycles of 30 s at 95°C, 30 s at the annealing temperature, 60 s at 72°C. Product formation was assayed using the SYBR Green I/HRM Dye detection format (465 nm excitation, 510 nm emission), and melting data were obtained by first cooling the product to 55°C for 30 s and then heating to 99°C with five data acquisitions/°C. PCR products were purified with the High Pure PCRProduct Purification Kit (Roche) and sequenced using the BigDye Terminator v3.1 kit chemistry (Applied Biosystems). Standard sequencing reactions comprised 40 ng PCR product, 1× BigDye sequencing buffer, 0.125× BigDye reaction mix, 4 pmoles primer and UltraPure DNase/RNase-free distilled water to give a final volume of 20 μl. Modified reactions comprised 40 ng PCR product, 1× BigDye sequencing buffer, 0.125× BigDye v3.1 reaction mix, 0.0625× dGTP BigDye v3.0 reaction mix, 4 pmoles primer, 0.95 M betaine (Sigma), 5% (v/v) dimethyl sulfoxide (Sigma) and UltraPure DNase/RNase-free distilled water to give a final volume of 20.05 μl. The modified reactions were carried out to avoid early signal loss when sequencing difficult regions such as those with high GC/GT/G content and/or containing small hairpins or other secondary structures. Cycling parameters were: 2


of the maize protein, invalidating any further comparisons with the predicted secondary structure of the barley protein.

![Two views of the X-ray crystallographic structure of a maize cytokinin dehydrogenase protein.\
The β-strand--turn--β-strand motif that forms a finger on the surface of the protein is highlighted. The structure is PDB ID IW10 and is viewed using the iCnS3D web-base structure viewer at <https://www.ncbi.nlm.nih.gov/Structure/icn3d/full.html?complexity=3&buidx=1&showseq=1&mmdbid=29226>.](pone.0225899.g004){#pone.0225899.g004}

![Secondary structure of the FAD binding domains of the barley HvCKX2.1 protein and a maize cytokinin dehydrogenase protein.\
The Barley 1 and Barley 2 sequences are HvCKX2.1 incorporating the alternative versions of the substitutions at positions 149 and 194. Maize 1 is the secondary structure of a maize cytokinin oxidase/dehydrogenase as predicted from its amino acid sequence, and Maize 2 is the actual secondary structure of this maize cytokinin oxidase/dehydrogenaseaccording to the DSSP analysis of the X-ray crystallographic data of the protein complexed with N6-(3-methoxy-phenyl)adenine (PDB 3DQ0 available at <https://www.rcsb.org/structure/3DQ0>). Structural codes: pink barrel, α-helix; yellow arrow, β-strand; blue hooked arrow, turn; grey wavy line, coil. Note that the alignment between and the barley and maize amino acid sequences around barley position 149 is slightly different to that shown in [S2 Fig](#pone.0225899.s007){ref-type="supplementary-material"}.](pone.0225899.g005){#pone.0225899.g005}

Geographical distributions of the *HvCKX2*.*1* haplotypes {#sec009}
---------------------------------------------------------

We examined the geographical distributions of wild plants of different haplotypes, to assess if the absence of haplotype 3 in landraces could be due to the geographical location(s) of the earliest farming sites in the Fertile Crescent being such that haplotype 3 was not sampled when wild plants were first taken into cultivation. Haplotypes 1--3, which comprise 67, 43 and


51 wild accessions, respectively, have overlapping geographical distributions in the wild population ([Fig 6](#pone.0225899.g006){ref-type="fig"}). Wild accessions with haplotype 1 are distributed throughout the Fertile Crescent and are also present in central Asia, including the Balkan region of western Turkmenistan. Haplotype 2 is present in the northern Fertile Crescent and central Asia, but absent from the wild barley population in the southern Levant. Wild accessions with haplotype 3, the haplotype absent in domesticated barley, are distributed throughout the Fertile Crescent. The current distributions within the Fertile Crescent of haplotypes 1 and 3 are therefore very similar, and in the northern part of the arc both distributions include the full range of haplotype 2.

![Distributions of wild accessions belonging to different haplotypes.\
Maps were plotted using ArcMap 10.2.1 of ArcGIS (ESRI. ArcGISnumber of years after that. For all the naysaying of PG, I think that this shift was probably the best answer that anybody could have come up with. How do you go about topping the stunts of a guy like Mick Foley? The truth is that you can’t, not without someone getting killed or the broken neck count going through the roof. It’s no coincidence that a number of people wrestling through 1999-2007 ended up with any number of concussions and spinal injuries. The fact is, when stunts just keep getting bigger and more dangerous, you’ve only got two choices – top it with something more dangerous, or make a concerted effort to dial it all back. That’s where the need for the family audience comes in.

The fear


Ampullosine, a new isoquinoline alkaloid from Sepedonium ampullosporum (Ascomycetes).
A new isoquinoline alkaloid, ampullosine (3-methyl-isoquinoline-6-carboxylic acid, 1), was isolated from Sepedonium ampullosporum and characterized by spectroscopic analysis and chemical reactions. This compound is responsible for the deep yellow color of the culture fluid of this species. Moreover, the known compounds sepedonin (2) and anhydrosepedonin (3) were detected. Twelve strains belonging to eight species of Sepedonium have been screened for these three metabolites by LC/ESI-SRM (selected reaction monitoring). Ampullosine (1) could be detected in almost all species in Sepedonium, but not in the phylogenetically more distant species S. brunneum and S. tulasneanum. Anhydrosepedonin (3) showed antifungal activity against the phytopathogenic fungus Cladosporium cucumerinum.  } catch (ClassNotFoundException e) {
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fundamental choices among competing municipal policies are resolved by a responsible organ of government. It also requires that a municipality protect individuals against the arbitrary exercise of municipal power, by assuring that fundamental policy choices underlying the exercise of that power are articulated by some responsible organ of municipal government. McGautha v. California (1971), 402 U.S. 183, 256, 270, 91 S.Ct. 1454, 28 L.Ed.2d 711. The Eastlake charter provision ignored these concepts and blatantly delegated legislative authority, with no assurance that the result reached thereby would be reasonable or rational. For these reasons, the provision clearly violates the due process clause of the Fourteenth Amendment."
Decisions of other states rejecting zoning by the procedure of initiative and referendum emphasize state statutes requiring notice and public hearing to an individualnot a part of the legislative function to grant permits, make special exceptions, or decide particular cases. Such activities are not legislative but administrative, quasi-judicial, or judicial in character. To place them in the hands of legislative bodies, whose acts as such are not judicially reviewable, is to open the door completely to arbitrary government.' Ward v. Village of Skokie, 26 Ill.2d 415, 186 N.E.2d 529, 533 (1962) (Klingbiel, J., specially concurring).
"The Supreme Court of Washington, in reviewing a rezoning decision, recently stated:
`Whatever descriptive characterization may be otherwise attached to the role or function of the planning commission in zoning procedures, e.g., advisory, *238 recommendatory, investigatory, administrative or legislative, it is manifest * * * that it is a public agency, * * * a principle [sic] and


good reason to believe that the official mind would change, he could not invoke the doctrine of equitable estoppel. The doctrine is not here applicable for two reasons: 1) the official mind not only did not change, but continuously negotiated with Andover to amend and revise its plans subsequent to approval by the official mind to ameliorate objections of individual citizens, and 2) in Sakolsky v. City of Coral Gables,[12] the the Florida Supreme Court candidly receded from the "red flag doctrine". This court in City of Gainesville v. Bishop[13] applied the doctrine of equitable estoppel even though red flags were soaring. The overwhelming evidence in this case clearly shows that Andover, in relying upon a valid zoning ordinance, expended a large sum of money in purchasing land,which is unimproved except for the U.S. Coast Guard Station which is situated on the Indian River. Along the southwestern boundary of the subject property is a tract of land zoned R-4 permitting multi-family residences. Proceeding along the southern boundary of the disputed property in an easterly direction from this R-4 property is a 13-acre parcel of land zoned single family development which is owned by appellant. Again proceeding easterly along the southern boundary of the disputed land is a series of residential lots which run to the Atlantic Ocean. The residential lot which is immediately adjacent to the southeastern boundary of the subject property is undeveloped.
[2]  North Beach Property Owners Association v. City of New Smyrna Beach, 276 So.2d 73 (1 Fla.App. 1973).
[3]  In support


Patient and hospital characteristics associated with average length of stay.
This article examines the relationship between patient, hospital characteristics, and hospital average length of stay controlling for major disease categories. A constellation of patient and physician factors were found to be significantly associated with average hospital length of stay.and outdoors

It is possible for the spring to immediately bounce the rim to where the shot has being created which isn’t food for the player

Things To Consider When Getting Portable Basketball Hoop

LOCATION

Before purchasing your basketball hoop systems, you’ll need to have a location with a lot of room for setting the hoop. A cleared location is generally the best, making garages a mainstream alternative.

If you choose to put a basketball hoop system in the city or walkway, simply make certain to remember road security. A few neighborhoods forbid establishment on these open spaces, so check with your district first.

VARIOUS HOOPS

Below are the type of hoops;

In-Ground

These hoops are secured into the ground with concrete, making them a decent choice for families who anticipate that this should be a piece


The LYNX Blue Line Extension officially begins revenue service Friday, March 16. Starting at 9:30 a.m. at the UNC Charlotte Main Station, grand opening celebrations will take place along the extension throughout the day. Students are encouraged to come out to the UNC Charlotte Main Station to take full advantage of their CATS All-Access Pass to explore the city and all it offers.

Check out these opening day festivities taking place along the line:

UNC Charlotte Main Station

Wilson's World broadcast

6:30 to 9 a.m.

Start the day at the UNC Charlotte Main Station as WCCB’s Wilson’s World broadcasts live on location. IKEA will be on site with coffee and cinnamon buns during the broadcast.

UNC Charlotte’s Blue Line Extension Grand Opening Celebration

9:30 to 11 a.m.

At 9:30 a.m., the University will kick off itsIntroduction {#Sec1}
============

Provision of care for a child with a long-term health condition is often associated with negative health outcomes in caregivers, for instance, depression, stress, anxiety and low self-efficacy were reported in caregivers \[[@CR1]--[@CR6]\]. Cerebral palsy (CP) is the most common paediatric disability causing long-term functional limitations \[[@CR7], [@CR8]\]. Children with CP most often present with multiple impairments, activity limitations and participation restrictions \[[@CR9], [@CR10]\]. More so, due to its diverse and complex presentation, CP is envisaged as the prototype paediatric disability \[[@CR7], [@CR8]\]. As such, most children require lifetime extensive assistance in functional day to day activities \[[@CR10]--[@CR12]\]. The level of required assistance depends on the severity of impairments, activity limitations and participation restrictions \[[@CR13]\]. Taking care of a child is part of normal parenthood; however, the


For instance, the caregiver acts as the provider, decision maker, companion, custodian and advocator for a child with a disability \[[@CR21]\]. Thus, routine assessment/screening of caregiver burden is of paramount importance for optimal functional outcomes of children with disabilities.

Given the well-documented effects of caregiving on the health of caregivers, it is important to routinely screen for caregivers burden/strain \[[@CR5]\]. This is only attainable through the use of psychometrically sound outcome measures \[[@CR14]\]. According to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines, an outcome measure has to be valid, reliable and responsive in order for it to adequately capture the construct it is purposed to measure \[[@CR22]\]. Over the past few decades, there has been an exponential increase in the number of outcome measures{#Sec13}

The four-point COSMIN checklist \[[@CR22], [@CR27]\] will be used to assess the methodological quality of the reviewed studies. This is essential to prevent the risk of selecting and evaluating tools which were developed using designs with poor methodological rigour \[[@CR22]\]. The COSMIN checklist rates the rigour of the reliability, validity, responsiveness, hypothesis testing, interpretability and generalizability of studies on the development and use of health-related patient-reported outcomes \[[@CR22], [@CR27]\]. Items are rated on a four-point Likert scale, i.e. "excellent", "good", "fair" and "poor". Where details are not published, the authors of the article will be contacted to achieve the most truthful rating of the assessment tool and to decrease bias in the analysis.

### Psychometric properties and data extraction {#Sec14}

The psychometrical properties will be evaluated using the checklist as


hint of sweetness at the same time. Really good stuff. So good, we immediately ordered another portion.

I am not sure if this technically qualifies as sashimi, as it isn’t raw anymore, but it was good, whatever you called it. Pricey at PHP280 or so for just a few pieces (the equivalent of half a kilo of lechon!), but worth it. I suppose several Japanese restaurants have this on offer, and you can see the entire tentacle in their chilled display cases, but somehow they don’t usually look as fresh as this batch seemed to be. I wonder if there is some secret to making this (or is it a specific species of octopi?) or if I can just poach some fresh octopus myself… :)

Eating little live octopus is                    78                                                82

Model 1; Support Vector Machine (SVM)-based 51 genomic biomarkers.

Model 2; SVM based on 51 genomic biomarkers and Genomic Allergen Rapid Detection input concentration.

Abbreviation: CLP, Classification, Labelling, and Packaging.

#### GARD cellular protocols

All cellular protocols associated with GARDpotency are identical to those of GARDskin, which has been previously described ([@kfaa068-B15]; [@kfaa068-B21]). For further details, the GARD SOP is available and attached to


utilized in GARDpotency is attached as [Supplementary material](#sup1){ref-type="supplementary-material"} 2.

#### Gene expression analysis

All gene expression analysis using the NanoString GEN2 nCounter system, for both generation of the GARDpotency training dataset and subsequent application of the GARDpotency assay in the interlaboratory ring trial, was performed according to protocols provided by the supplier (NanoString Technologies). In short, isolated RNA samples were thawed on ice and quality controlled using the Agilent 2100 Bioanalyzer (Agilent Technologies, Santa Clara, California). RNA samples were hybridized to the GARDpotency-specific probe pairs and assayed in the nCounter system, using recommended kits and reagents.

#### Training dataset exploration and prediction model optimization and finalization

NanoString raw data were imported into the R statistical programming environment ([@kfaa068-B35]) and RNA-content normalized using a single-sample counts per total counts algorithm, as previously describedwere trained and evaluated in an iterative cross-validation exercise. In each iteration, 10-fold data were left out, whereas an SVM was trained on retained data and used to classify the left-out data. The predictions of left-out samples were recorded, and iterations proceeded until each sample had been left out once. Results are listed in [Table 1](#kfaa068-T1){ref-type="table"} (Model 1) and a cumulative predictive accuracy was calculated to 78%.

### GARDpotency Prediction Model Rationale and Optimization

It has previously been observed that information relating to sensitizing potency of chemicals correlates with the concentration in which chemicals are assayed ([@kfaa068-B20]). [Table 1](#kfaa068-T1){ref-type="table"} includes information of the chemical-specific GARD input concentration for each of the 51 sensitizers included in the training dataset. These concentrations were further explored and correlated with known sensitizing potency parameters, ie, LLNA


picking 2 r when two letters picked without replacement from dqdqddqrddqdrmrqqd?
1/51
What is prob of picking 2 m when two letters picked without replacement from {o: 1, c: 1, g: 1, m: 2, k: 1, b: 1}?
1/21
Calculate prob of picking 3 b and 1 c when four letters picked without replacement from {p: 3, y: 1, c: 5, z: 8, b: 3}.
1/969
Calculate prob of picking 1 r, 1 k, and 2 g when four letters picked without replacement from rgkkkee.
0
Three letters picked without replacement from {u: 1, s: 6, i: 11}. What is prob of picking 2 i and 1 s?
55/136
Calculate prob of picking 2 c when two letters picked without replacement from iicicibbbcc.
6/55
Calculate prob of picking 2 f and 2 e when four letters picked without replacement from1. Field
At least some of the various embodiments are directed to radio frequency identification (RFID) readers and RFID tags utilizing a reduced number of interactions for the RFID reader to acquire some or all of the data payload of the RFID tags.
2. Description of the Related Art
In many circumstances a RFID reader may be in the presence of a plurality of RFID tags; however, the data payload of RFID tags is broadcast from the RFID tags one at a time to ensure the transmissions do not collide. In conventional systems the RFID reader and RFID tags perform a series of communications to isolate a single RFID tag (also known as selecting or singulating the RFID tag) to which the RFID reader then directly communicates to acquire the data


neither RFID tag has a slot counter value of zero, neither RFID tag communicates to the RFID reader. The RFID reader, in turn, issues a “QueryRep” command, which forces the RFID tags to decrement their slot counter values. After the “QueryRep” command, the first RFID tag has slot counter value of zero, and the second RFID tag has slot counter value of one. The first RFID tag broadcasts a tag identifier (e.g. a 16 bit random number, which may also be referred to as a “handle” or “RN16”). The RFID reader returns an acknowledgement (by returning the tag identifier), and the first RFID tag then transmits some or all of the data payload (e.g. electronic product code or other data stored in the tag memory). At further commandVehicle registration plates of Niger

The vehicle registration plates of Niger is a legal form requiring the citizens of Niger to have the car registered.

Regular license plates

License plate Niger with European shape and size. The current scheme of regular license plates for private vehicles Niger introduced in 2005. It has 1A2345 format, where 1 - the area code, A - Series, 2345 - number. Regular plates have a white background with black signs. At the right side of the plate are image maps of the country in the colors of the national flag or a simple black silhouette of the country, under which the code has RN. There is a two-line version of license plates. License plate for motorcycles format: A1 / 2345 where A - Series 1 -


.
-5, c, -1, 2
Let j(o) = -3*o + 19. Let t be j(6). Suppose 0 = -2*c - 2*z - 6, 11 = -3*c + 2*z - 3*z. Put t, 0, c in ascending order.
c, 0, t
Let c = 1 + 0. Let y be (-75)/180 + -1 + 15/9. Sort c, -1, y in descending order.
c, y, -1
Suppose -5*v - 20 = 4*x - 3*x, -4 = v - 4*x. Put 3, -1, v in descending order.
3, -1, v
Suppose m = -2*m - 2*x + 7, -5*x = -3*m + 35. Suppose -2*g - 2*g = z - 13, -3*z - 2*g = -9. Put m, 3, z in ascending order.
z, 3, m
Suppose 0*a = 4*a, -n + 5 = -4*a. Let h(v) = -v - 6.15 = -3*y - 3*f, -2*f = -5*y + 14. Put y, u, -2 in decreasing order.
y, -2, u
Let d = 1 + -3. Let g(j) = -2*j - 1. Let m be g(d). Put m, -2, 0.1 in descending order.
m, 0.1, -2
Let q = 3.9 - 4. Let a be (-4)/18 + 16/(-252). Sort -0.3, q, a.
-0.3, a, q
Let v(d) be the second derivative of -d**4/3 + 2*d. Let b be v(-1). Let h be 2/(-1)*10/(-4). Put b, h, -1 in decreasing order.
h, -1, b
Let w be ((-17)/(-34))/(((-21)/(-8))/3). Sort 3/8, -0.5, w, 1/2 in decreasing order.
w, 1/2, 3/8, -0.5
Let d(u) = -u**2 - 5*u - 9. Let c be d(-2). Let n(t) = -4*t**3 + t + 1. Let s be n(-1). Suppose s*z + 4 =


million in budget cuts sought by a federal control board overseeing the island's finances. The island's governor has proposed the cuts be reduced to $241 million, but no deal has been reached.

RELATED: Puerto Rico Oversight Board Approves GDB Liquidation Plan

The Morning Rundown Get a head start on the morning's top stories. This site is protected by recaptcha

"Unfortunately, the university is being targeted by a disproportionate ... and unfair funding cut that not only places the university's physical integrity at great risk, but also the capacity it still has to attract top-quality teachers," the board members who resigned said in a letter to Gov. Ricardo Rossello.

The University of Puerto Rico serves more than 50,000 students across 11 campuses. The system already has been hit with nearly $350 million inand is bounded if the scatterer is composed entirely of positive permittivity materials (Figs. \[fig:tm\_scat\_cs\]e and \[fig:tm\_scat\_cs\]f). This observation is consistent with superscattering effects expected in lossless metallic nanoparticles [@ruan2010superscattering; @ruan2011design; @mirzaei2014superscattering] due to the existence of surface-plasmon modes with aligned resonant frequencies.

![image](figure_TM_cs.pdf)

In conclusion, this letter outlined a bounding procedure for absorptionless electromagnetic devices. As an example, we used it to study upper limits on scattering cross-sections of 2D electromagnetic metallic and dielectric scatterers. The generality of the bounding procedure makes it an attractive technique to understand fundamental limits for a variety of electromagnetic design problems. Furthermore, while we have focused on the problem of bounding fields from absorption-less electromagnetic devices, the procedure outlined in this paper can be integrated with the approaches outlined in refs. [@kwon2009optimal; @yu2010fundamental; @miller2016fundamental; @molesky2020t; @venkataram2020fundamental;


Correction to: *Scientific Reports* 10.1038/s41598-018-30834-7, published online 16 August 2018

This Article contains errors in the Reference list. Reference 26 is incorrectly listed as 'Cook, J. R. D., Diego, S., Kubelick, Kelsey, P., Luci, Jeffrey, Emelianov, Stanislav, Y. in *SPIE BiOS*.' The correct reference 26 appears below as ref. [@CR1].

Additionally, reference 27 is incorrectly listed as 'Kubelick, K. P., Snider, E. J., Ethier, C. R. & Emelianov, S. Photoacoustic Properties of the Anterior Eye. *Journal of Biomedical Optics* (In Preparation) (2017).' The correct reference 27 appears below as ref. [@CR2].
+ 74. Suppose -7*u + j*u = 3*l - 16, 0 = -4*l + u + 6. Suppose -l*b + 4*g = -56, -5*g = b + 11 - 4. What is the remainder when 52 is divided by b?
16
Let k = -70 - -110. Suppose k*j - 45*j = 0. Suppose -3 = d - j*d - 5*p, 3*d - 4*p = 46. Calculate the remainder when 84 is divided by d.
18
Let d = 32 - 35. Let p = d - -10. Suppose -p = -n + 7. Calculate the remainder when 51 is divided by n.
9
Calculate the remainder when ((-290)/435)/(1078/(-1074) + 1) is divided by 47.
38
Let u = 3548 - 3219. What is the remainder when u is divided by 74?
33
Suppose -l = -3*k +


 illl)   \\ll ~ gro" ing l lUl or. any and all

knmvn or unknown. suspected or 1111 suspcctcd personal injuries lo or death              orpct itinner rcsuIt ing
frnm. or alleged to have resulted rrnm. the llu "accination administered on September 18. 2012.

as alleged by petitioner in a petition for vacc ine compensation filed on Februar: 11. 2015. in the

United States Court orFcderal Claims as petition            o. 15-l-12V.

         1-1. II' petitioner should die prior to cntr) ofjudgmcnt. thi s agreement shall be voidable

upon proper not ice 10 the Court on behalf of ei ther or bothQ:

how to run a function in child scope after parent scope gets restful data

My page have parent and child scope. child scope displays a list belongs to a data in parent scope.
For example,
There is a department with three employees. Department is in parent scope and employees are retrieved in the child scope.
The problem is parent scope get the department by restful api call. Then, child scope call another api to get employees in the department.
By doing this, child scope needs to know the department in parent. However, chlid scope api call is often triggered before parent gets the department. So end up displyaing no employees even though there are.
I am seeking a solution for this.

A:

You can watch Department model in child scope and whenever you get Department model


element, which is their appetite for risk. I'll consider each of these elements in turn.

The outlook is too uncertain?

On the surface, uncertainty seems like an appealing explanation for subdued investment. However, we should remember that firms always have to make investment decisions in an environment of uncertainty, not just about the prospects for the macroeconomy but also for their industry. Rather, the question we need to ask is whether uncertainty in recent years has been elevated?

There are a number of ways that we might try to measure the extent of uncertainty. One measure is the volatility of firms' share prices (Graph 5). Another is the dispersion of analysts' forecasts of firms' earnings (per share). A third can be constructed by looking at the proportion of news stories thatRCEM VISION 2020

RCEM Vision 2020 is our plan to fix emergency department Staffing, Systems and Support to deliver excellent patient centred care. You’ll find out where we are now and why our vision is needed, along with details of how we aim to fix emergency medicine in the tabs below.

Where are we now?

During the Autumn of 2017 the challenges facing NHS Emergency Departments (EDs) are less in the news, but the problems they face have not gone away. In our view, presently, the system is just coping after a terrible winter performance in many parts of the UK: there is an urgent need for action to tackle the problems facing Emergency Care.

There is a myth that patients are choosing to come to Emergency Departments instead of other services


whereas the facts show that the growth is in step with the rising population in the UK. Since 2010/11 attendances in England have increased by 1,031,164 (7.4%) – equivalent to the workload of 10 medium sized departments – and this number is set to rise.

Patients rightly expect to be seen, treated, and admitted or discharged in under four hours – the national standard. But the workforce and resources are not growing to meet this demand — demand which has historically defied all attempts to reduce it. As a result, emergency care staff are working to the very limits of their abilities, 12-hour patient waits have increased, performance has declined to the worst for 15 years and safety is increasingly compromised.

The NHS’s emergency medical workforce is simply not largeQ:

Ubuntu upgrade process failed

I tried to dist-upgrade my ubuntu server on my percona cluster but it failed with this message
The following packages have unmet dependencies:
libmysqlclient18 : Depends: libmariadbclient18 (= 5.5.33a+maria-1~precise) but it is not installable

And here is the package listing
# dpkg --list | grep -E 'percona|mysql'
ii  libdbd-mysql-perl                   4.020-1build2                     Perl5 database interface to the MySQL database
iU  libmysqlclient18                    5.5.33a+maria-1~precise           Virtual package


Donald Trump, who led a years-long movement to prove President Barack Obama was born in Kenya and thus ineligible to be president, abandoned that position in a speech in Washington Sept. 16, 2016.

"Hillary Clinton and her campaign of 2008 started the birther controversy," Trump said. "I finished it. I finished it. You know what I mean. President Barack Obama was born in the United States. Period. Now we all want to get back to making America strong and great again."

At PolitiFact, our Flip-O-Meter judges whether someone has been consistent on an issue. The rating is not making a value judgment. Indeed, voters often like politicians who are flexible and have the ability to compromise or adapt their positions to the wishes of constituents. Still, accusations of shifting positionsare so common in politics that it is valuable to have us provide an analysis of a shift and rate the amount of change.

Trump previously took credit for Obama releasing his long-form birth certificate and pledged to donate $5 million to charity if Obama released his passport records.

"A book publisher came out three days ago and said that in his written synopsis of his book, he said he was born in Kenya and raised in Indonesia. His mother never spent a day in the hospital," Trump said in 2012.

"His grandmother in Kenya said, 'Oh no, he was born in Kenya and I was there and I witnessed the birth.' Now, she's on tape and I think that tape's going to be produced fairly soon ...The grandmother in Kenya


entire
archive and recover 80% of the original tapes.

------
Shivetya
I admin a few of iSeries, one large LPAR with half a dozen others. We have
zSeries and pSeries around too and nothing small.

With regards to iSeries we have developers who have put in place more than a
few REST services both with IBM code and Profound Logic code. IBM provides
both custom web service programs (think collection of DLLs) and other simpler
interfaces. The key is you can reuse a lot of existing code by putting a good
web interface on the front of it and your customers would never know.

The number of large companies using the platform is quite high and includes
many big names people would not expect as well as a certain major league
sport. Overseas it seems more accepted to say you are([@bib11] *preprint*) and BioVU at Vanderbilt University ([@bib80]; [@bib26]) are interrogated by medical and population geneticists, there are new opportunities to develop approaches for analyzing multiple phenotypes in a single genomic study.

In particular, a fundamental question mega-biobanks can answer is whether shared genetic architecture among multiple phenotypes is detectable using summaries of germline genetic variation. [@bib77]) explicitly tested for pleiotropy among 42 complex traits, focusing on identifying colocalized variants in GWA studies for pairs of traits \[see also [@bib39]), who tested for colocalization between eQTLs and associated variants for the same phenotype\]. While phenome-wide association studies (PheWAS; [@bib24], [@bib25]) and multivariate GWA studies have tested for statistical association between variants and multiple phenotypes ([@bib48]; [@bib67]; [@bib31]; [@bib89]; [@bib92]), these studies (including [@bib39]; [@bib77]) share the central challenge of


*N* phenotypes, this approach therefore yields *N* feature vectors. The more significant genes two phenotypes share, the closer their features vectors will be. Choosing a norm on the vector space in which the feature vectors lie allows us to compute pairwise distances between any two feature vectors, resulting in an *N* × *N* matrix of pairwise distances---we note that different norms will result in different distance matrices, and we use this fact in this study to emphasize different parts of a feature vector when identifying prioritized clusters (herein, "prioritized clusters" refers to groups of phenotypes with very strong affinity). Once a distance matrix has been computed, we can use clustering algorithms (in our case, Ward hierarchical clustering) to divide the set of phenotypes into disjoint groups that separatepower of WINGS for that simulation would be the percentage of those five clusters that are identified as prioritized. The precision of WINGS is the percentage of those five ground truth clusters that have been both correctly identified as prioritized and are within the five most prioritized clusters identified in that simulations.

###### Power, precision, F1 scores of WINGS across a range of phenotypes included as well as shared genetic architecture

        Shared genetic architecture


three SD from the mean are considered outliers under the mean outlier criterion ([@bib63]; [@bib70]). Under the quartile outlier criterion, branch length gaps that are \>1.5 interquartile ranges above the upper quartile, or below the lower quartile, are marked as outliers ([@bib81]; [@bib43]; [@bib63]; [@bib70]). Finally, the Grubbs' outlier criterion uses Grubbs' test to remove outliers one-by-one based on statistically testing the hypothesis that the data contain no outliers ([@bib33]; [@bib70]). The appropriate choice of outlier criterion depends on the input data and objectives. For example, the mean outlier criterion is faster but less robust than the median outlier criterion ([@bib81]; [@bib63]; [@bib70]). The mean and Grubbs' methods assume the input data are normally distributed, whereas the quartile and median methods are useful when the input data areto medical genomics researchers, approaches for leveraging these datasets to identify shared architecture among phenotypes are still in their infancy. Existing approaches for analyzing the shared genomic underpinnings of multiple phenotypes focus on colocalizing variant-level signals ([@bib25]; [@bib77]). However, recent approaches that aggregate SNP-level genotype-phenotype association statistics within genes into a gene-level association score have gained power to detect biologically relevant and interpretable genes and pathways enriched for mutations in complex diseases ([@bib12]; [@bib58]; [@bib72]; [@bib95]; [@bib104]), and offer insight into the roles of genetic heterogeneity and interactions among variants in generating complex diseases.

Here, we present a new method, Ward clustering to identify Internal Node branch length outliers using Gene Scores (WINGS), for identifying phenotypes that share significant genetic architecture based on germline genetic data matched with binary


extensive list of replication citations). Second, based on Figure S1, clustering does not work well when applied to a group of phenotypes that have different genetic architectures, in particular quantitative phenotypes and binary phenotypes, as the differences in gene score distribution will cluster binary and continuous in a noninformative manner. One approach that could help overcome this challenge is the development of a gene score that incorporates both effect sizes and their SE into calculation ([@bib90]), but this is outside the focus of this study.

Third, although WINGS is robust to the cluster size threshold and outlier criterion (see section *Parameter sensitivity analysis*; [Figure 5](#fig5){ref-type="fig"}), WINGS is more sensitive to the clustering criterion and the gene scores used as input. We focused on Ward hierarchical clustering here, due partlygene-level association method PASCAL (Table S3).

Future applications and extensions of WINGS may focus on a number of questions regarding shared genetic architecture among phenotypes. For example, [@bib77]) tested variants for true pleiotropy, while our current implementation of WINGS cannot differentiate between phenotypic relationships defined by clinical comorbidity *vs.* causal dependence (see also [@bib25]). We also assume that ICD10 codes are reliable indicators of disease status, which may not be the case ([@bib85]; [@bib42]); for example, ICD10 codes may reflect billing codes for tests but not validated diagnoses. One potential follow-up analysis is to experimentally test the pleiotropic effect of shared significant genes in prioritized clusters, as these would be ideal candidates for drug design. WINGS provides a new hypothesis generating framework that can be used to identify primary


    of an individual’s performance of a major life activity cannot establish that an

     individual is disabled; there must be a “significant restriction” of an individual’s

     performance of a major life activity. See Albertson’s, Inc. v. Kirkingburg, 527

     U.S. 555, 565-66 (1999).

5.   In this regard, courts must consider how each impaired individual seeking relief

     under the ADA performs major life activities, and “mitigating measures must be

     taken into account in judging whether an individual possesses a disability.” Id. at

     565. There is “no principled basis for distinguishing between measures

     undertaken with artificial aids, like medicationsto

     Dr. Kuiper’s questions regarding how he would accomplish above-shoulder work.

     This does not suggest that Dr. Kuipers believed that McClure’s impairment

     significantly limits his ability to perform a class or broad range of jobs. Second,

     Dr. Kuipers felt that McClure would not be able to perform all of the functions of

     an electrician at the Arlington plant. Although Dr. Kuipers was not aware of the

     essential functions of the position, he was aware that General Motors was building

     a body shop facility at the Arlington plant and that General Motors was hiring


is slightly overrated. I mean, would I really bring much more to a law school if I worked for a year after UG, even if it's the exact same type of job I've done before?

Maybe, maybe not. I'll have 2 years of WE under my belt upon starting in the fall and my cycle's gone far better this time around than two years ago. However, my WE looks fairly decent on a resume and weighing that against the sinking medians at many schools makes the answer unclear. It can't hurt you, that's for sure, but only an adcom, not anyone in this thread, will be able to provide an answer.

From this interview with JS, WE seems to be valuable for the maturity it brings about in the applicant:

Fromyear old is honestly getting on the older side.

Also, I think while it may be a preference, I think it is also because it is hard for to weigh and compare UG participation and softs. It's easy to know exactly what an investment analyst does and how hard she works, but it's hard to compare that with a student athlete. Or, perhaps that investment analyst was also a student athlete--now quite honestly, her softs are just better. So it could be that, as we've expected, KJDs overall have worse softs.

By and large, no, not for the most part. That's not really the point though. A lot changes after college and as a result you have to develop as a person. True, some may have experienced a lot of


maturity of a sixteen year old, and sixteen year olds who are just the opposite. Some people get it and others don't. It's unfair, but the notion that it's more likely that somebody who's worked for a couple years before coming in will have a better idea of what they want to achieve (and therefore be more likely to find employment) isn't that bizarre and adcoms probably feel it's a little bit of a safer bet, statistically.

I honestly don't even know what my softs are considered. I was a PAC12/Big12/Big10 (sorry, don't want to give too much away lol) athlete so literally all of my UG softs are related to that in some way (particpation, community service, All-American....etc). My resume probably looks so one-sided which I'm assuming isa negative. But whatever, I didn't have time for anything else because of sports and I can't go back :/

But now I'm in my one-year gap year working as a paralegal so hopefully that adds some dimension.


Build

Design has change dramatically over the past decade and applying these principles to information technology has made a lasting impact. The fact is, there are literally thousands of permutations available to solve a given problem or challenge. Understanding the 'art of the possible' and blending it with existing assets and culture to achieve the desired business outcomes sometimes requires stepping back and unshackling yourself from the day to day.

We use design thinking principles, architecture and engineering to design solutions that adhere to modern standards while adapting to your existing assets, skills and capabilities.1. Field of the Invention
The present invention relates to a printed circuit board, and more specifically, to a printed circuit board having a via and a forming method thereof.
2. Description of the Prior Art
Printed circuit boards are necessary components in the electronics industry, which can be applied to electronic products' motherboards for mounting other electronic components and providing wires to be utilized by other electronic components. Alternatively, a printed circuit board can be an adapter of a semi-product and mount the semi-product on a motherboard. Processing steps of a printed circuit board according to a related art include drilling, electroplating, wire etching, pressing, anti-soldering, tin-emitting etc. When a printed circuit board is utilized as an adapter, an application method of it is to drill and electroplate the adapter