by 234 drugs), transporter proteins (67 proteins targeted by 181 drugs), and other types of targets (51 types, targeted by 84 drugs). The best represented target classes were the G-protein coupled receptors (GPCRs) in the receptor group, the hydrolases in the enzyme group, and the voltage-gated ion channels in the transporter protein group ([@R203]; [@R360]).

Observed inhibition in *in vitro* protein assays often reflects binding of the test compound to the active center of the target protein, thereby blocking it. In other cases, the assay might be designed to reflect the inhibition of a protein--protein interaction required for the functional activity, or protein activation induced upon compound binding. While these assays inherently provide a "mechanism of activity" of the identi-fied inhibitor or agonist, they cannot guarantee its functionality insmaller variety of compounds, and the major disadvantage is that more crude extracts need to be biologically assayed ([@R280]).

Crude plant extracts exhibiting biological activity are subjected to iterative bioactivity-guided fractionation cycles until the respective pure bioactive compounds are identified \[[Table 5](#T5){ref-type="table"}; ([@R280])\]. Since the fractionation and bioactivity evaluation of the generated fractions are very laborious steps, it is critical to obtain reliable bioactivity data with the crude plant extracts, optimally in independent complementary bioassays. Typically, liquid--liquid extraction ([@R195]; [@R335]) using organic solvents of different polarity (e.g., ethyl acetate, *n*-butanol, and chloroform) in water is conducted as a first fractionation step. In order to guide the isolation process, fractions obtained from bioactive crude extracts are subjected to biological investigation (best in direct comparison with the crude extract). Following each


product library ([@R282]), that can be used for different bioactivity tests, including HTS. Starting the bioactivity screening with pure compounds has many advantages including better compatibility with HTS and prevention of many difficulties, which come along with extract testing as mentioned above. However, using this approach, time and effort need to be invested in advance for the isolation of the natural compounds without any guarantee that the respective compounds will finally have a relevant bioactivity. Next to the possibility for HTS with libraries composed of randomly selected natural products, a variety of knowledge-based strategies can be applied for the assembly of focused natural product libraries including just natural products with certain characteristics (see Section 3.1). In this respect, a good prioritization approach might be to use chemography topharmacological assays allow HTS, this approach is advantageous, since many HTS approaches that do not work well with plant extracts due to interferences with ubiquitous perturbing compounds, could be successfully applied to enriched fractions ([@R112]; [@R173]; [@R181]; [@R211]). In addition to HTS with libraries of randomly obtained plant-derived fractions, also in this occasion different knowledge-based strategies can be applied for the assembly of focused libraries containing just fractions with certain characteristics (see Section 3.1). For example, an approach for selection of extracts and fractions based on their drug-like physicochemical properties was recently developed ([@R60]).

Since the bioactivity of a plant extract may be the result of synergistic interactions of several components, and in this case bioactivity-guided fractionation might fail, a synergy-directed fractionation strategy was recently developed ([@R217]). This approach


plant species are threatened to varying degrees ([@R389]). Two thirds of the estimated 50,000 medicinal plant species currently used are collected from the wild, raising concerns about issues such as diminishing populations, loss of genetic diversity, local extinctions, and habitat degradation ([@R62]). While isolation of natural products directly from the plant species in which they occur is often acceptable if small to moderate amounts of the respective compounds are needed (for example for the supply of sufficient quantities for small-scale experimental laboratory work), additional routes for resupply need to be considered once there are increased market demands for the respective natural product. In these cases natural products can be resupplied by the application of plant cell and tissue culture, heterologous production, total chemical synthesis, or semi-synthesis from isolated*M*, remains in the desired final product ([Eq. (1)](#FD1){ref-type="disp-formula"}). $$\mathit{AE} = \frac{M_{\text{product}}}{\sum M_{\text{reactants}}} \times 100\%$$

When molecules are transformed, waste material is produced in most cases, depending on the type of reaction mechanism. For example, addition and rearrangement reactions tend to be more atom economic while substitution and elimination reactions do not. When extending the concept to a reaction sequence composed of a number of individual steps, the intermediate compounds do not appear in [Eq. (1)](#FD1){ref-type="disp-formula"} because they cancel from the overall net reaction equation. A reactant is defined as any component which contributes atoms to intermediate or final products, even if none of the reactant eventually remains in the final product as it is the case in protection--reaction--deprotection sequences. Catalytically active species, solvents and other auxiliary components are


cell lung cancer (*Bcl-2 inhibitor*)

  Picropodophyllotoxin\                 *Podophyllum hexandrum* Royle, replaced by *Sinopodophyllum hexandrum* (Royle) T.S. Ying ([@R206])   1 trial: Glioblastoma, gliosarcoma, anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, anaplastic ependymoma (*tubulin binding/IGF-1R Inhibitor*)

  Quercetin\                            *Allium cepa* L. ([@R39])                                            costs about a dollar
per shot after initial expenses. The higher resolution might not matter on
monitors, but it makes a huge difference in size limitations and sharpness
when printed, and prints are generally the goal for artists.

True large format like 4x5 costs something like $10 a shot depending what film
you use (I've heard it can cost a lot less if you shoot cheapo medical b&w),
but has insane resolution, measured in gigapixels. You can print it wall-
sized, no problem. On top of that, you can only perform the full range of
movements such as tilt shift and correcting for some types of perspective
distortion on a large format field camera.

This stuff does not matter for photojournalist or weddings or sports, but many
professional artists still choose film. They never really stopped. This is in
contrast


Likewise with photography, you can use a digital or film camera and
then you can view the image on a print from a darkroom or on your computer
monitor.

It seemed as though you were using the term "hipster" to imply vinyl was more
about style and trend. If that is the case, I wouldn't characterize the sonic
differences between analog and digital recordings as simply "hipster"
differences. There is a quantifiable difference between an analog and digital
wave. Not saying one is better than the other but they are different.

Your argument that the differences with film vs. digital seemed to boil down
to the economics of the two mediums not any aesthetic difference. That is
interesting because off the top of my head I don't think there is any scenario
in music recording where it becomes cheaperto go analog. I believe, in
general, analog recording is more expensive.

~~~
Nav_Panel
> You are comparing vinyl to film but in the way you are doing it you are
> implicitly comparing the experience of the consumer of the audio with the
> producer of the image.

> Your argument that the differences with film vs. digital seemed to boil down
> to the economics of the two mediums not any aesthetic difference. That is
> interesting because off the top of my head I don't think there is any
> scenario in music recording where it becomes cheaper to go analog. I
> believe, in general, analog recording is more expensive.

You are correct, my apologies. From the producer standpoint, analog recording
techniques offer few benefits compared to digital.

I didn't argue from an aesthetic viewpoint because I don't


The
other is simulating a tube sound without tubes. I believe the first part of
the equation is where things are going wrong.

A cheap amp and speaker with a DSP simulated tube sound being run through it
will still sound like a cheap amp and speaker. There may be high end
manufacturers making high quality guitar amps with emulation, but I'm unaware
of them. They haven't been present in the music store on any occasion I've
gone in to select a new amp.

The brands I'm aware of doing "tube emulation" in amps are brands I would
never buy, at any cost. Behringer, Line 6 (and this is considered one of the
good ones, honestly, and they do sound better than most, but are still cheaply
constructed), Tech21 (again, decent, but not high end). All pretty shitty amps
that“Catalogue of 1-3 GHz Solar Flare Radio Emission,” Astronomy and Astrophysics, 104, 145-160, 1994. Such spikes can reach amplitudes that are several orders of magnitude more intense than the broadband microwave continuum, see, e.g., the above-referenced H. Isliker et al., “Catalogue of 1-3 GHz Solar Flare Radio Emission.” Spike bursts have durations of tens to hundreds of milliseconds, although detailed statistics do not yet exist. The physical processes producing the spikes are uncertain. One proposal, based on the intensity of the burst, is a maser-type process. The center frequencies of the spike bursts vary from spike to spike, and from large burst event to event. The bandwidth of the bursts is variable, ranging from a fraction of a percent to a few percent of the central frequency, see,


in hCPCs overexpressing CYGB vs. vector control. Full-length blots are presented in Supplemental Fig. [S15](#MOESM1){ref-type="media"}. (**b**) Representative DAR-1 staining images and quantitative analysis for hCPCs infected with CYGB- or vector-lentivirus for 48 hours. (**c**) Representative images and quantitative analysis showing the traces for the measurement of nitric oxide levels by chemiluminescence in hCPCs overexpressing CYGB vs. vector control following the treatment with 100 µM 1400 W or vehicle. See experimental details in the Material and Methods Section. (**d**) Representative FACS analysis with DAR-1 staining showing the NO level in hCPCs overexpressing CYGB vs. vector control following the treatment with 100 µM 1400 W or vehicle. \*Indicates *p* \< 0.05 vs. control; \*\*indicates *p* \< 0.01 vs. control; n = 3 independent experiments.

To determine whether iNOS, downstream of NFкB, played a role in the cytoprotective effect associated with CYGB, we overexpressedset against human CYGB were purchased from GeneCopoeia. Lentiviruses were packaged by Lenti-Pac FIV expression packaging kit according to the manufacturer's instructions (GeneCopoeia). Split hCPCs to be infected at proper density in a 6-well tissue culture plate in 2 ml of F-12 complete media. Seed the proper number of plates for the number of experiments being run. The proper controls and replicates were included. Cells were incubated in a 37 °C incubator at 5% CO~2~ overnight undisturbed. An infectious viral titer needs to be determined prior to infection in order to calculate the amount of viruses to be added. Polybrene were added to the 1 mL of virus/media for a final concentration of 5 ug/mL. Finally, 1 mL of media containing virus was added to the plated cells.

Specific knockdown of NFκB and iNOS


all non-infected cells died eventually (2--3 days). In order to obtain stable transfected cells, hCPCs were further cultured in puromycin-containing growth medium for up to 10 days. The efficiency of gene knockdown was subsequently confirmed by Western blot.

Cell viability assay {#Sec13}
--------------------

LDH release assay, a simple approach to measure cellular membrane integrity, was applied to determine the oxidative stress-induced cell death in hCPCs. The procedures were exactly followed according to manufacturer's instructions from Cytotoxicity LDH Detection kit (Takara). The day before CYGB-lentivirus infection, hCPCs were seeded at the density of 1 × 10^4^ per well in a 96-well plate. After 24 h infection, cells were exposed to 2 mM H~2~O~2~ for 3 hours, which condition was optimized based on previous studies^[@CR30]^. The plate was then centrifuged at 250 × g for 10 min. 100 μl of the supernatantSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This study was supported by the NIH Grant R01HL114951 (to C.C.) and the AHA grant 16GRNT312280002 (to D.J.). We appreciate all of our colleagues from the Divisions of Pediatric and Adult Cardiothoracic Surgery at the Albany Medical Center, including Kyla Philbrook and Karen Larsen, for their assistance in obtaining consent from patients for the cardiac tissue collection.

C.C., S.Z., D.J.: conception and design, data analysis and interpretation, and manuscript writing and revision; S.Z., X.L.: conduct the majority of experiments; S.Q.: conduct the initial LDH assay; F.J.,: NO measurements, data discussion; N.D., E.B.: consenting, and collection of human cardiac tissues.

Competing Interests {#FPar1}
===================

The authors declare that they have no competing interests.


investment firm known today as Janney Montgomery Scott. Her mother was Charlotte Hope Binney Tyler Montgomery, whose family had made its fortune in banking. In 1923, Helen Hope Montgomery married Edgar Scott, an investment banker and heir to a railroad fortune. After her marriage, Scott began to appear regularly on the New York Couture Group's annual list of best-dressed women. Her beauty and slim, angular figure (size eight throughout her life) was much admired, inspiring artists such as Cecil Beaton and Augustus John. Scott became famous for hosting lavish parties at Ardrossan, the Montgomerys'  estate in Radnor, Pennsylvania, where she entertained notables of society, government, and the arts, including W. Averell Harriman, Cole Porter, and Katharine Hepburn.  Her son, Robert Montgomery Scott, was also a philanthropist,biological function. Less space and no access to a nest box did not increase the choice for more space or a nest box, respectively, over food in the preference tests. However, reduced floor space reduced behavioral freedom and denying access to a nest box eliminated the opportunity for the motivated behavior of laying their eggs in a discrete enclosed nest box, both of which presumably provide hens with the opportunity for positive affective experiences.


25 injured in separate incidents of violence in Jammu

Jammu, July 3 (ANI): At least 25 people were injured today in separate incidents of violence in Jammu over the revocation of the transfer of land to the Amarnath Shrine Board even as the curfew was imposed in the city on the third day.

2048 showcase - abimaelmartell
http://abimaelmartell.com/2048-showcase/

======
Houshalter
This is nice. Is this all of them?

~~~
abimaelmartell
I think i'm missing some

i'm doing a search in hn for "2048" to get more games.


it, he said. University President Drew G. Faust also agrees with the move, according to College spokesperson Rachael Dane.

Last week, Khurana said he personally feels uncomfortable with the title and that the College’s House masters, faculty members who oversee student residences, have been discussing changing it for some time. While acknowledging that the title “master” can take on various meanings—it is often used to mean “teacher”—he also argued that it is important to consider the “social meaning” of the phrase.

“As someone who is responsible for and co-leads one of the Houses…. I have not felt comfortable personally with the title,” Khurana said in an interview.

Ronald S. Sullivan, Jr., a master of Winthrop House, called the change “the product of many years” of discussion, but said House masters collectivelylong-term results of the RCT have been published.[@B14] The study found that DB reconstruction maintains significant superiority for SB reconstruction regarding anterior and rotational stability during the 3- to 12-year follow-up. The Tegner score was also better in the DB group; however, there were no differences in the other subjective findings.

A few pieces of biomechanical evidence suggest superiority of DB reconstruction for rotational stability.[@B15],[@B16] Our recent *in vivo* biomechanical study using a triaxial accelerator (KiRA, Orthokey, Lewes, DE, USA) indicated that DB reconstruction better controls rotational instability than SB reconstruction during the pivot-shift test (under submission).

BETTER UNDERSTANDING OF NORMAL ACL ANATOMY TO SEEK A BETTER RECONSTRUCTION ROUTE
================================================================================

Previous knee observation studies have described anatomic placement for femoral tunnels. The position and area for each DB of the AM and


PL portions of a natural ACL was described by its central structure with the surface membrane removed.[@B17]

A macroscopically normal ACL consists of small, 1-mm diameter bundles, based on our observations. Detailed observation of the divided smaller bundles will lead to a better understanding of tunnel placement during anatomic ACL reconstruction. A normal cadaveric ACL was divided into AM and PL bundles and separated into ten 2-mm diameter bundles. Their attachment sites were marked with colored markers. The positional relationship between the femoral and tibial attachments of each small bundle was investigated. Small bundles constituting the ACL have a relatively layered arrangement between the two attachments. The results indicate that the tibial attachment form two patterns of oblique and transverse types. The vascular bundles were located in the centerfemoral insertion of the ACL macroscopically, histologically, and immunohistologically using embalmed cadaveric knees. They reported the variety of femoral insertion methods for the ACL and described that the insertion area was relatively wide and separated from the posterior cartilage. They concluded that femoral ACL insertion observed macroscopically corresponded to direct insertion observed microscopically. The posterior portion behind the lateral intercondylar posterior ridge was the indirect insertion microscopically and appeared membrane-like macroscopically. Mochizuki et al.[@B21] measured the direct (fibrous) and indirect (membranous) attachment areas separately as 50.8 ± 12.6 m^2^ and 91.4 ± 23.7 m^2^, respectively. The different opinions regarding direct and indirect femoral attachments of a normal ACL may be related to differences between young fresh ACLs and elderly cadaveric embalmed ACLs.

HAS DB ACL RECONSTRUCTION IMPROVED?
===================================

DB reconstruction using


TO PRESENT
==========================================================

The ACL remnant has been preserved, at least at the tibial attachment point, as a landmark for the tibial tunnel since 1989 when medial hamstring tendon ACL reconstruction started in our hospital. Remnant-preserving procedures have been practiced along with the technical improvements and the significant advantages of remnant-preserving procedures.

However, the meaning of ACL remnant volume itself has not been well investigated. Therefore, the background of remnant volume was investigated retrospectively. Eighty-eight patients underwent 105 unilateral DB anatomic ACL reconstructions between 2006 and 2008 and were followed up for ≥ 24 months and preoperative knee laxity was evaluated under anesthesia. Postoperative outcomes were evaluated based on knee extension and flexion strength, manual laxity tests, KT measurements, etc. Overall knee condition and sports performance were evaluated with the Lysholmprocedures was compared on 3D-CT. Two approaches were practiced consecutively from 2010 to 2012 to create femoral tunnels during DB ACL reconstruction. One approach was the standard approach from the front in which the ACL remnant is peeled off from the attachment, and two guidewires were inserted based on anatomic bony landmarks (standard group). The other approach was the new behind-remnant approach in which the ACL remnant remains untouched and two guidewires are inserted at the posterior margin of the direct ACL insertion site (behind-remnant group). A total of 75 CT scans (36 in standard group and 39 in behind-remnant group) were analyzed. The position of the AM and PL femoral tunnels was expressed on a 3D-CT scan using the quadrant method described by Bernard et al.[@B23] An


were utilized in 1,992 (46.0%) and 206 (4.8%) of analyzed patients, respectively.

Statistical analysis
--------------------

The distributions of categorical variables between the patients who received right-sided RT and those who received left-sided RT were compared using chi-square tests. The baseline date was defined as the last day of adjuvant RT for breast cancer. Time to disease was defined as the time between the last day of RT for breast cancer and the date of diagnosis. To estimate the cumulative incidence of subsequent cardiac disease after exposure, accounting for the follow-up period, hazard plots were generated using the Kaplan-Meier method. Cumulative incidence curves according to risk factors were compared with the log-rank test. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) to controlcovariates and differences in follow-up periods. All analyses were conducted using SPSS Statistics version 20 (IBM Corp., Armonk, USA).

RESULTS
=======

Patient characteristics
-----------------------

Patient characteristics and tumor characteristics of all patients are described in [Table 1](#T1){ref-type="table"}. Among all patients, 733 (16.9%) were under 40 years, 1,900 (43.8%) were 40--49 years, 1,199 (27.7%) were 50--59 years, and 501 (11.6%) were 60 years or older. BMI was available in 3,894 (89.9%), and obese women (BMI ≥25) were 1,099 (25.4%) of all patients. Smoking history was available in 3,477 (80.2%) patients and 92 (2.1%) of all patients were smokers. Diagnoses of hyperlipidemia, hypertension, and diabetes were identified in 335 (7.7%), 254 (5.9%), and 201 (4.6%) patients, respectively. Of all patients, 2,256 patients were treated with right-sided RT and 2,077 patients were treated with left-sided RT.


Characteristics of the patients and tumors did not differ between the patients who received left breast RT and those who received right breast RT ([Table 1](#T1){ref-type="table"}).

Incidence of cardiovascular disease and risk factor analysis
------------------------------------------------------------

Median follow-up was 8.1 years (range, 0.2--21.5 years). During the follow-up period, 69 patients experienced cardiovascular disease; the median time to development of disease was 5.5 years (range, 0.5--15.1 years). Among these patients, 45 developed angina and 24 developed other ischemic heart diseases; the median time to disease onset was 5.9 and 3.5 years, respectively. The cumulative incidences of cardiovascular disease were 0.8%, 2.0%, and 3.1% at 5, 10, and 15 years, respectively ([Table 2](#T2){ref-type="table"}). [Table 3](#T3){ref-type="table"} shows the cumulative incidence of cardiovascular disease according to the risk factors and estimated HR of factors by univariateand multivariate analysis. In univariate analysis, age of 50 years or more (*p*\<0.001), BMI ≥25 kg/m^2^ (*p*\<0.001), smoking (*p*=0.042), hyperlipidemia (*p*\<0.001), hypertension (*p*\<0.001), diabetes (*p*\<0.001), and administration of trastuzumab (*p*=0.010) were the significant risk factors associated with higher risk of cardiovascular disease. The significant risk factors (*p*\<0.05) in univariate analysis and tumor laterality were included in the multivariate analysis. Multivariate analysis showed that an age of 50 or more (HR, 1.073; 95% CI, 1.048--4.099; *p*\<0.001), smoking (HR, 5.991; 95% CI, 2.109--17.022; *p*=0.002), hyperlipidemia (HR, 5.567; 95% CI, 3.235--9.580; *p*\<0.001), and trastuzumab (HR, 2.214; 95% CI, 1.040--4.711; *p*=0.039) were the significant risk factors for cardiovascular disease. Tumor laterality was not a significant risk factor for cardiovascular disease in either uni- or multivariate analysis (*p*=0.443 and *p*=0.428, respectively).

Risk of cardiovascular


2 wiki and Dragon Age wiki (going to work on the gameplay tips guide -- can't wait!). Once Lydia isn't so busy with reviews she'll get back to Guild Wars 2 -- why not help out in the meantime? :) Leo is settled on the Valkyria Chronicles series wiki, especially with VC3 coming.

On a sidenote, our hardware side is in a bit of a state at the moment. If you didn't catch the notices on Twitter/FB, you should check out our affiliate Overclocker's Club for the next while until things get back to normal:

If you're curious on the backstory, basically it's just the usual ebb and flow -- some folks are leaving because of school and whatnot, so our new guy Chris Ledenican is taking on pretty muchCephalopod egg fossil

Cephalopod egg fossils are the fossilized remains of eggs laid by cephalopods. The fossil record of cephalopod eggs is scant since their soft, gelatinous eggs decompose quickly and have little chance to fossilize. Eggs laid by ammonoids are the best known and only a few putative examples of these have been discovered. The best preserved of these were discovered in the Jurassic Kimmeridge Clay of England. Currently no belemnoid egg fossils have ever been discovered although this may be because scientists have not properly searched for them rather than an actual absence from the fossil record.

Taphonomy

Ammonite eggs in well-aerated sea bottoms probably would have quickly been broken down by scavengers and aerobic bacteria. Fossil evidence supports this general idea since swarms of hatchling ammonitellae fossils are


Time to try a sumatriptan injection. $400 a pop, can’t waste them. Trembling too much to self-inject, so boyfriend came over to help. Hoping this works.

10 p.m.: Starting to feel some relief. Must be what it feels like to get hit by a train. Have to figure out a way to catch up on two nights [of lost] sleep and recover in time for work tomorrow.

April 27, 2012Living With Migraines: The 5 Best and Worst Parts of Being a MigraineurThese are the 5 hardest parts of living with migraines:

1. A life of prevention: Constantly in fear of the next migraine, we carry pills with us everywhere (abortive medications, such as triptans and midrin, which work in the brain to stop the migraine process) and heed our doctor’s instructions.wonderful, supportive boyfriend

Studied for and passed the bar

Rented my own apartment

Learned new hobbies like cooking and photography

Adopted a kitten

Ran a 5K

Started changing my career path to pursue what I really enjoy

Taken control of my health

Reviewing this list makes me so happy. I didn’t focus on the negative: For example, I didn’t focus on how many ER visits it took for me to pass law school and the bar. I didn’t mention that I had to leave my job primarily due to migraines. I didn’t mention that I couldn’t even get past the first day of a part-time job because of a migraine. I didn’t get into my insurance battles.

Try to focus on the positive. That’s a great lesson for us all.

June 15, 2012Living With Migraines: Prevention at the


medication so far this summer. Being more aware of my triggers and being upfront with others about how I’m feeling has helped me so far.

July 10, 2012Living With Migraines: “Every migraine is like a snowflake.”My boyfriend said this a few weeks ago, and it completely helped me understand the non-migraineur perspective.

For example, sometimes I feel a migraine starting, and one sumatriptan helps it go away immediately. Other times, I feel a migraine starting and it increases in pain and severity so rapidly that taking a sumatriptan completely incapacitates me. (Typically after I take it, the headache stage of the migraine attack gets worse before it gets better; and even after it works, I have to lie down or sleep.)

When he said this, it really helped me understand thethe SWAT Team entered the residence, they found Harmonic dead from an apparently self-inflicted gunshot wound, according to the Sheriff's Office.

Francis and Bernice Campbell have lived in the Little Lake Weir subdivision across the street and one home site west of Harmonic's residence for four years and have a clear view of his front yard.

Francis Campbell, vice president of the Little Lake Weir Homeowners Association, said Monday that he and his wife knew both the deceased man and the gunshot victim.

Campbell said Harmonic was from Ohio. He said he had talked with him last Thursday, after he cut Harmonic's grass. He said they discussed family issues Harmonic was facing and that Harmonic mentioned he might sell his home.

Campbell said he had stepped out for a while on Sunday


lb. limit at the time.

The ring size and promotion as a whole were also geared towards the visiting titlist, as was the case in May ’10 when Malignaggi was forced to welcome Khan to town in the Brit’s stateside debut. The weigh-in for that fight saw a posse literally known as Khan’s Army massively outnumber the modest cast of supporters Malignaggi was permitted to bring to the event, a scenario that nearly became costly once a mini-riot ensued.

While both of those situations could be deemed as problematic, Malignaggi entered both fights as the challenger and thus “only” as the hometown fighter. He understood the nature of the business involved in those fights, though his loss to Khan was his last under original promoter Lou DiBella.

“That was like myfifth fight in two years on a Golden Boy card,” Malignaggi recalled of the nature of the business at the time, which included his epic post-fight rant following a controversial points loss to Juan Diaz in Aug. ‘09. “I figured, they had the pull and I was getting my salary from their shows, might as well join them.”

The move made plenty of sense. Plans were already in place for Golden Boy to stage a regular boxing series at Barclays, which at the time was still in the process of being built. As long as Malignaggi kept winning, he would become an integral part of the series.

Malignaggi has since won five straight, including a welterweight belt though almost in spite of his promoter. The former 140 lb. titlist worked


beat his ass and this guy still gets the decision, everyone will know why.”

Jake Donovan is the Managing Editor of Boxingscene.com, as well as a member of Transnational Boxing Ratings Board and the Boxing Writers Association of America. Twitter: @JakeNDaBox@"OBJC_IVAR_$_MyWork._data", !dbg !143
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    die support surface of the substrate and connected to the substrate, e.g. by wire bonds. A heat spreader is placed on the support surface of the substrate over the die, with the heat spreader supporting arms rigidly affixed onto the supporting surface using, for example, a cement or adhesive, such as an epoxy cement or adhesive or glue. Then this assembly is placed over a mold cavity in an injection mold, so that the upper surface of the upper portion of the heat sink is at the bottom of the mold cavity and the substrate surface contacts the edges of the upper opening of the mold cavity. Then the molding compound is injected into the cavity, where it encloses the die and the wire bonds and the supporting


molding material to harden to form a mold cap.
In another general aspect the invention features a process for forming a TEPBGA with a partially embedded heat spreader, by placing a heat spreader having an upper portion and a plurality of support arms onto the die support surface of a substrate such that at least one of the supporting arms of the heat spreader is affixed to the substrate using a resilient fixative such as an elastomeric adhesive; placing a mold cavity over the heat spreader; injecting the molding material into the cavity; and permitting the molding material to harden to form the mold cap. The resilient fixative holds the heat spreader in the appropriate position in relation to the substrate during injection of the molding material, and as1. Field of the Invention
The present invention relates to the field of network management, and more particularly to processes for determining whether two communicating network drivers are directly connected across a physical link.
2. Background of the Invention
In the management of data networks, it is often desirable to understand the topology of the network, including whether there are direct links between particular devices in the network, the nature of the network intermediate devices which interconnect links or end stations on the network, and the capabilities of individual end stations on particular links. Thus, network management stations often maintain a topology map for the network to assist an administrator in the management of the network. A variety of techniques has been developed for automatically discovering the topology of the network


extensive pool table cloth options. Extra charges may apply for a one-piece slate.Trip charges apply*.

Pool Table Move & Recovering of Tables Sold by Game Room Guys

$850 – This dual package includes all the benefits of our pool table moving and recovering packages to save you money and get you set up in no time! Includes tear down, reassembly, and travel time. Does not include rail rubber. Cloth and supplies are extra. Check out our extensive pool table cloth options. Extra charges may apply for a one-piece slate.Trip charges apply*.

Custom Felt Installed for Tables Sold by Game Room Guys

We provide custom logo felt for your home or establishment. Below is an example of custom work that we did for Ferris State University. Please contact us for a quote, asAmphiphilic zinc phthalocyanine photosensitizers: synthesis, photophysicochemical properties and in vitro studies for photodynamic therapy.
Peripherally and non-peripherally tetra-substituted zinc(ii) phthalocyanines bearing 2-(2-{2-[3-(dimethylamino)phenoxy]ethoxy}ethoxy)ethoxy and 2-(2-{2-[3-(diethylamino)phenoxy]ethoxy}ethoxy)ethoxy groups (, , and ) were synthesized by cyclotetramerization of the corresponding phthalonitriles (, , and ). Their quaternized ionic derivatives (, , and ) were also synthesized by the reaction of them with methyl iodide. The novel compounds were characterized by using standard spectroscopic techniques such as FT-IR, (1)H NMR, (13)C NMR, UV-vis, mass and elemental analyses. The obtained quaternized phthalocyanines (, , and ) showed amphiphilic behaviour with excellent solubility in both organic and aqueous solutions, which makes them potential photosensitizers for use in photodynamic therapy (PDT) of cancer. The photophysical (fluorescence quantum yields and lifetimes) and photochemical (singlet oxygen and photodegradation quantum


yields) properties of these novel phthalocyanines were studied in DMSO for both non-ionic and ionic quaternized derivatives. However, these properties were examined in both DMSO and phosphate buffer solution (PBS) for quaternized ionic phthalocyanines. The effects of the positions of substituents (peripheral or non-peripheral) and the quaternization of the nitrogen atoms on the substituents about their photophysical and photochemical properties were also compared in this study. The bovine serum albumin (BSA) binding behaviours of the studied quaternized ionic zinc(ii) phthalocyanines were also described in PBS solutions. The quaternized phthalocyanines (, , and ) successfully displayed light-dependent photodamage in HeLa and HuH-7 cancer cells in photodynamic therapy treatment. The photosensitivity and the intensity of damage were found directly related to the concentration of the photosensitizers.galaxy besides a dwarf spheroidal. It suggests that galaxy formation is highly stochastic for halo masses of $\sim 10^{10}$–$10^{11} M_\odot$, with stellar masses varying by factors of 100 or more at fixed halo mass. This idea has been suggested as a solution to the problem of missing massive Milky Way satellites – the so-called “too big to fail” problem (Boylan-Kolchin[ et al. ]{}2011). However, the stochastic solution has been generally rejected as implausible, with extreme stochasticity in simulations expected to set in at much lower masses (Brook & Di Cintio 2015; Sawala[ et al. ]{}2015; Wheeler[ et al. ]{}2015). The results for VCC 1287 raise the possibility that there are unidentified massive galaxies lurking at still lower surface brightnesses, and that these DM halos are [*not*]{} too big to fail.

Key questions are what is the


with our present photometry.

To address the question of whether VCC 1287 is typical of UDGs, total masses for more UDGs must be obtained. Determining stellar velocity dispersions for these faint systems is expensive (or impossible) for 10m-class telescopes. Here we have demonstrated a more inexpensive route through the kinematics of GC systems, at least for UDGs out to Virgo cluster distances. However, we suggest the most efficient approach comes from simply counting up the number of GCs in UDGs. We find excellent agreement between the halo masses inferred from dynamics and from counting GCs for VCC 1287, and this approach offers an inexpensive route to obtaining [*virial masses for UDG systems out to Coma distances*]{} (see also Mihos[ et al. ]{}2015). For example, based on the calibrations of Harris[ et al. ]{}(2013), for “dwarf-mass”halos ($M_{\rm halo}\approx10^{10}$ [M$_\odot$]{}) we would expect $\sim$5 GCs in a UDG. For a quenched Milky-Way-like galaxy ($M_{\rm halo}\approx10^{12}$ [M$_\odot$]{}) we would expect $\sim200$ GCs.

Relatively shallow $HST$ imaging (or deeper, multi-band ground-based imaging) of these systems will allow for estimates of the total GC populations of UDGs, hence $M_{\rm halo}$, and ultimately a better understanding of these galaxies.

Acknowledgments
===============

We thank Giuseppina Battaglia for use of her maximum likelihood code, Claudio dalla Vecchia for assistance with the EAGLE simulations and Jesus Falcón Barroso and Nacho Trujillo for useful discussions. MAB and IMN were supported by the Programa Nacional de Astronomía y Astrofísica from the Spanish Ministry of Economy and Competitiveness, under grants AYA2013-48226-C3-1-P, AYA2013-48226-C3-2-P, AYA2013-48226-C3-3-P. MB acknowledges financial support from MINECO under the 2011 Severo Ochoa Program MINECO SEV-2011-018. AJR was supported


by NSF grant AST-1515084. DMD acknowledges support by the Sonderforschungsbereich (SFB) 881 of the German Research Foundation (DFG). This article is based on observations made with the Gran Telescopio Canarias (GTC), in- stalled in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, on the island of La Palma. We acknowledge the Virgo Consortium for making their simulation data available. The EAGLE simulations were performed using the DiRAC-2 facility at Durham, managed by the ICC, and the PRACE facility Curie based in France at TGCC, CEA, Bruyères-le-Châtel.

[50]{} natexlab\#1[\#1]{}

Beasley, M. A., Cenarro, A. J., Strader, J., & Brodie, J. P. 2009, , 137, 5146 Behroozi, P. S., Wechsler, R. H., & Conroy, C. 2013, , 770, 57 Bertin, E., & Arnouts, S. 1996, , 117, 393 Binggeli, B., Sandage, A., &lost step due to interpolation, but if I turn the interpolation off, then I immediately notice the stuttering.
I went for 0.008s step because I found it a good value to avoid rounding errors (which happens on 0.0083333s for 120fps), which helps a lot to keep stability between runs in different architectures.
EDIT:
Since PCs use a IEEE 754 representation of floating numbers, 128fps seems to be a sweet spot, since it's:

Divisible by two (giving less precision errors)
At least two times higher than 60fps (which should be most people rendering frequency)

Consider using this value.


of 25,473 men at the start of the battle, and it was further reinforced by the British Royal Marines unit 41 (Independent) Commando and the equivalent of two regiments from the 3rd and 7th Army Infantry Divisions. The UN forces had a combined strength of about 30,000 men during the course of the battle. The UN forces at Chosin were also supported by one of the greatest concentrations of air power during the Korean War, since the 1st Marine Aircraft Wing stationed at Yonpo Airfield and five aircraft carriers from the US Navy's Task Force 77 were able to launch 230 sorties daily to provide close air support during the battle, while the US Air Force Far East Combat Cargo Command in Japan reached the capacity of airdroppingthe East Hill giving way. As the Chinese tried to advance from the East Hill, they were cut down by the 31st Tank Company.

By 1 December, the PVA 58th Division was virtually destroyed, with the remainder waiting for reinforcements from the 26th Corps of the 9th Army. Much to the frustration of Song Shilun, the 26th Corps did not arrive before the Marines broke out of Yudam-ni. The airfield was opened to traffic on 1 December, allowing UN forces to bring in reinforcements and to evacuate the dead and wounded. With the Marines at Yudam-ni completing their withdrawal on 4 December, the trapped UN forces could finally start their breakout towards the port of Hungnam.

Breakout

After a short rest, the breakout began on 6 December, with the 7th


Royal Marines Commando and RCT-31 were awarded the Presidential Unit Citation for their tenacity during the battle. Fourteen Marines, two other soldiers and one Navy pilot received the Medal of Honor, and all of the UN troops that served at Chosin were later honored with the nickname "The Chosin Few". On 15 September 2010, the Veterans of the Korean War Chosin Reservoir Battle memorial was unveiled by the United States Marine Corps Commandant General James T. Conway at Camp Pendleton.

The PVA 9th Army suffered 19,202 combat casualties, and 28,954 non-combat casualties were attributed to the harsh Korean winter and lack of food.  Total casualties thus amounted to 48,156 - about one third of its total strength. Outside of official channels, the estimation of Chinese casualties has beenhad been together three years and were planning to get married next year. Roach had a teenage son and daughter. Roach’s mother, Helen Seiber Lane, runs a beauty shop also on Willow Lane in Rocky Top, according to Facebook posts.


Big Gundown

Lee Van Cleef, Tomas Milian, Fernando Sabcho. Enhanced by a masterful original score by Ennio Morricone, this classic Spaghetti Western finds a seasoned bounty hunter on a serious mission to track down a savage Mexican outlaw who raped and murdered a 12-year-old girl. Includes 2 Blu-ray Discs with a bonus DVD and a CD of Morricone’s soundtrack. Diretced by Sergio Sollima. 1966/color/95 min/NR/widescreen.

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Lee Van Cleef, Tomas Milian, Fernando Sabcho. Enhanced by a masterful original score by Ennio Morricone, this classic Spaghetti Western finds a seasoned bounty hunter on a serious mission to track down a savage Mexican outlaw who raped and murdered a 12-year-old girl. Includes 2 Blu-ray Discs with a bonus DVD and a CD of Morricone’s soundtrack. Diretced by Sergio Sollima. 1966/color/95MERCHANTABILITY,
 * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT.  IN NO EVENT SHALL
 * THE COPYRIGHT HOLDER(S) OR AUTHOR(S) BE LIABLE FOR ANY CLAIM, DAMAGES OR
 * OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE,
 * ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
 * OTHER DEALINGS IN THE SOFTWARE.
 *
 * Authors: Ben Skeggs
 */
#include "nv50.h"
#include "channv50.h"

#include <core/gpuobj.h>

static void
nv50_fifo_runlist_update_locked(struct nv50_fifo *fifo)
{
	struct nvkm_device *device = fifo->base.engine.subdev.device;
	struct nvkm_memory *cur;
	int i, p;

	cur = fifo->runlist[fifo->cur_runlist];
	fifo->cur_runlist = !fifo->cur_runlist;

	nvkm_kmap(cur);
	for (i = 0, p = 0; i < fifo->base.nr; i++) {
		if (nvkm_rd32(device, 0x002600 + (i * 4)) & 0x80000000)
			nvkm_wo32(cur, p++ * 4, i);
	}
	nvkm_done(cur);

	nvkm_wr32(device, 0x0032f4, nvkm_memory_addr(cur) >> 12);
	nvkm_wr32(device, 0x0032ec, p);
	nvkm_wr32(device, 0x002500, 0x00000101);
}

void
nv50_fifo_runlist_update(struct nv50_fifo *fifo)
{
	mutex_lock(&fifo->base.engine.subdev.mutex);
	nv50_fifo_runlist_update_locked(fifo);
	mutex_unlock(&fifo->base.engine.subdev.mutex);
}

int
nv50_fifo_oneinit(struct nvkm_fifo *base)
{
	struct nv50_fifo *fifo = nv50_fifo(base);
	struct nvkm_device *device = fifo->base.engine.subdev.device;
	int ret;

	ret


would change its mind between now and when mass production starts.

The Bell acknowledges that it is still early in the phone's development cycle.

It's unclear whether Samsung will increase the overall size of the phablet to accommodate the bigger display or make the bezels slimmer.

Samsung hasn't been afraid of increasing the display size of a device in the past and it looks like the company plans to continue that tradition.

Will it have a notch?

The Samsung Galaxy Note 10 is expected to arrive in August next year, a year after the arrival of the Galaxy Note 9.

The anticipated adoption of the 6.66-inch screen is in line with the global smartphone trend for larger screens, aimed at appealing to users who spend more time watching videos and playing games on their//  Copyright Neil Groves 2009. Use, modification and
//  distribution is subject to the Boost Software License, Version
//  1.0. (See accompanying file LICENSE_1_0.txt or copy at
//  http://www.boost.org/LICENSE_1_0.txt)
//
//
// For more information, see http://www.boost.org/libs/range/
//
#ifndef BOOST_RANGE_ALGORITHM_SEARCH_HPP_INCLUDED
#define BOOST_RANGE_ALGORITHM_SEARCH_HPP_INCLUDED

#include <boost/concept_check.hpp>
#include <boost/range/begin.hpp>
#include <boost/range/end.hpp>
#include <boost/range/concepts.hpp>
#include <boost/range/detail/range_return.hpp>
#include <algorithm>

namespace boost
{
    namespace range
    {

/// \brief template function search
///
/// range-based version of the search std algorithm
///
/// \pre ForwardRange1 is a model of the ForwardRangeConcept
/// \pre ForwardRange2 is a model of the ForwardRangeConcept
/// \pre BinaryPredicate is a model of the BinaryPredicateConcept
template< class ForwardRange1, class ForwardRange2 >
inline BOOST_DEDUCED_TYPENAME range_iterator<ForwardRange1>::type
search(ForwardRange1& rng1, const ForwardRange2& rng2)
{
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<ForwardRange1> ));
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<const ForwardRange2> ));
    return std::search(boost::begin(rng1),boost::end(rng1),


           boost::begin(rng2),boost::end(rng2));
}

/// \overload
template< class ForwardRange1, class ForwardRange2 >
inline BOOST_DEDUCED_TYPENAME range_iterator<const ForwardRange1>::type
search(const ForwardRange1& rng1, const ForwardRange2& rng2)
{
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<const ForwardRange1> ));
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<const ForwardRange2> ));
    return std::search(boost::begin(rng1), boost::end(rng1),
                       boost::begin(rng2), boost::end(rng2));
}

/// \overload
template< class ForwardRange1, class ForwardRange2, class BinaryPredicate >
inline BOOST_DEDUCED_TYPENAME range_iterator<ForwardRange1>::type
search(ForwardRange1& rng1, const ForwardRange2& rng2, BinaryPredicate pred)
{
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<ForwardRange1> ));
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<const ForwardRange2> ));
    return std::search(boost::begin(rng1),boost::end(rng1),
                       boost::begin(rng2),boost::end(rng2),pred);
}

/// \overload
template<When an object is subjected to an impact force, a stress wave is transmitted through the object. This stress wave causes deformations in the internal structure of the object. As the object deforms it acts, in part, as a shock absorber, dissipating a portion of the mechanical energy associated with the impact. The ability of the object to dissipate mechanical energy, commonly referred to as the “damping capacity” of the object, depends on several factors, including the type and structural integrity of the materials making up the object.
There are instruments that are capable of measuring the damping capacity of an object. An example of such an instrument is described in U.S. Pat. No. 6,120,466 (“the '466 patent”), issued 19 Sep. 2000 and entitled “System and Method for Quantitative


static void updateSettings(final Context context, final boolean xmpp, final boolean mail, final boolean web, final Callback<Boolean> callback) {
        new Thread() {
            public void run() {
                try {
                    Log.i(LOGTAG, "Attempting to update settings.");
                    final Settings settings = Settings.getInstance(context);
                    finalMichigan Football: No Improvement For Rich Rodriguez, Wolverines

Something is broken with the Michigan Wolverines. Something is seriously wrong.

The team is 5-4 but they haven't improved from last season's 3-9 debacle. Call me crazy if you will, but allow me to explain.

Five wins. This is likely all Michigan will get. Purdue remains their last credible shot at a victory. They aren't going to beat Wisconsin on the road, and they aren't beating Ohio State.

Games that once looked winnable, now look hopeless. Getting blown out and flat out embarrassed by the hapless Illini will do that to you.

There will be no bowl game for the second consecutive year. If Michigan should get to six wins, they should respectfully be denied a bowl game. Wins over FCS opponents shouldn't be included


worst for the team and an average of 28 points allowed per game.

So they fired the defensive coordinator and hired Greg Robinson, a proven defensive genius to turn things around.

So far this year, Michigan has allowed 226 points with three games to go. That's an average of 25 points allowed per game.

A whopping three-point improvement.

We again have one of the worst defenses ever seen at Michigan. Five of nine opponents have dropped over 30 points on the Wolverines defense. That 2-6 Illinois team racked up over 500 yards of offense against Michigan for crying out loud!

Has this team bailed on Rodriguez? The question needs to be asked.

Just a few weeks ago, things were looking good. Michigan was heading for seven or eight wins and marked improvement.

Year Three was([@B22]). The generated *35S:NMig1* and *35S:NMig1-GFP* constructs were introduced into *Agrobacterium tumefaciens* strain C58C1 (pMP90), harboring the helper plasmid *pSoup*. The positive clones were selected on agar solidified YEB nutrient medium supplemented with 100 mg l^−1^ rifampicin, 100 mg l^−1^ spectinomycin and 50 mg l^−1^ gentamicin, and subsequently transformed into wild-type Col-0 plants by the floral-dip method ([@B8]). The primary transformants (T~0~) were selected on 50 mg l^−1^ kanamycin and their progeny genotyped with gene specific and *nptII* gene primers. The positive transformants were further tested by kanamycin selection and five representative transgenic lines (L1 -- L5) were generated. All analyses were carried out with homozygous T~3~ seedlings.

Plant Material and Growth Conditions {#S2.SS3}
------------------------------------

*Arabidopsis thaliana* seeds were surface sterilized, stratified for 2 days in the dark at 4°C, and


and mixed with 500 μl ice-cold 80% ethanol. The samples were centrifuged at 10 000 rpm for 30 min at 4°C and the supernatants were used for determination of antiradical activity by 2,2′-diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging assay, according to [@B5], and antioxidant capacity by Ferric Reducing Antioxidant Power (FRAP) assay, as decribed by [@B2].

The antiradical activity of the plant extract (40 μl) was measured by mixing it with DPPH solution (960 μl) in methanol (6.10^--5^M). The absorbance of the reaction solution at 515 nm was determined after 30 min of incubation at room temperature in the dark. The rate of antiradical activity was calculated by Trolox standard curve and the results were represented as μmol Trolox g^--1^ FW.

The antioxidant capacity assay is based on the reduction of ferricused for determination of lipid peroxidation and H~2~O~2~ content.

Lipid peroxidation was determined by the thiobarbituric (TBA) method, which quantifies the amount of malondialdehyde (MDA) as the end product of the lipid peroxidation ([@B17]). Reaction mixture contained 500 μl supernatant, 500 μl 0.1 M phosphate buffer (pH 7.3) ant 1 ml TBA (0.5% w/v). The samples were placed in a boiling water bath for 45 min. After cooling on ice, the sample absorbance was read at 440, 532, and 600 nm. The MDA extinction coefficient (ε = 155 mM^--1^ cm^--1^) was used for calculations of MDA concentration and expressed as nmol g^--1^ FW.

Hydrogen peroxide (H~2~O~2~) content was determined according to [@B48]. One ml of 0.1% TCA extract was mixed with 1.9 ml reagent (composed by 100 μM xylenol orange,


and density of all branching events under heat stress and salinity ([Figure 5D](#F5){ref-type="fig"}). The heat- and salt-mediated reductions in these parameters were significantly lower in *NMig1*-overexpressing lines, compared to Col-0. Exposure to heat stress resulted in more than 20% inhibition in the density of all initiation and formative events associated with lateral root development in Col-0, whereas in the overexpressors L2 and L3, this parameter was inhibited by only about 6% ([Figure 5D](#F5){ref-type="fig"}). Similarly, the inhibitory effect of drought and salinity on the density of all lateral root initiation events was at least twice lower in L2 and L3 than that observed in the wild-type.

![Inhibitory effect of various abiotic stress factors (heat shock, drought and salinity) on primary root length and lateral root development of 10-day-old wild-type seedlingswell-known stress responsive gene *HSP101* ([@B38]) in the transgenic plants and Col-0 under abiotic stress. Although some expression differences depending on the nature of the stress imposed were detected, all tested HSPs followed a similar expression pattern, featuring substantial increase in *NMig1* overexpressors and lower detected levels in Col-0. Based on these results, we suggest that the *NMig1*-mediated induction of the studied *HSPs* could represent another mechanism contributing to abiotic stress tolerance in Arabidopsis. However, the exact molecular link between the HSP accumulation and protective role of *NMig1*-induced expression under various stress conditions still needs to be studied and defined.

It should be also noted that the impact of *NMig1* overexpression in promoting plant tolerance varied depending on the nature of the stress imposed. Exposure to heat shock coincided


input)
   at System.Management.Automation.PowerShell.Worker.ConstructPipelineAndDoWork(Runspace rs, Boolean performSyncInvoke)
   at System.Management.Automation.PowerShell.Worker.CreateRunspaceIfNeededAndDoWork(Runspace rsToUse, Boolean isSync)
   at System.Management.Automation.PowerShell.CoreInvokeHelper[TInput,TOutput](PSDataCollection`1 input, PSDataCollection`1 output, PSInvocationSettings settings)
   at System.Management.Automation.PowerShell.CoreInvoke[TInput,TOutput](PSDataCollection`1 input, PSDataCollection`1 output, PSInvocationSettings settings)
   at System.Management.Automation.PowerShell.Invoke(IEnumerable input, PSInvocationSettings settings)
   at Cognifide.PowerShell.Core.Host.ScriptSession.ExecuteCommand(Boolean stringOutput, Boolean marshallResults)
   at Cognifide.PowerShell.Core.Host.ScriptSession.<>c__DisplayClass150_0.b__0()
   at Cognifide.PowerShell.Core.Utility.SpeTimer.Measure[T](String message, Boolean log, Func`1 action)
   at Cognifide.PowerShell.Core.Host.ScriptSession.ExecuteScriptPart(String script, Boolean stringOutput, Boolean internalScript, Boolean marshalResults)
   at Cognifide.PowerShell.Core.Host.ScriptSession.ExecuteScriptPart(String script, Boolean stringOutput, Boolean internalScript)
   at Cognifide.PowerShell.Core.Host.ScriptSession.ExecuteScriptPart(String script)
   at Cognifide.PowerShell.Client.Applications.PowerShellIse.ExecuteInternal(ScriptSession scriptSession, String script)
   at Cognifide.PowerShell.Client.Applications.ScriptRunner.Run()

A:

-Recurse should be in the bracket:
$root = "master:\content\home"
@(Get-Item -Path $root) + @(Get-ChildItem -Path $root -Recurse) |
Add-ItemLanguage -Language "en-us" -TargetLanguage "en-ca" -IfExist Skip

It's a parameter for Get-ChildItem command which means it should getbenefit could be that there is very precise control over good deployment positions. We opted for a real-time algorithm that can detect positions on official and custom objects alike. The detection still needs work, but we're optimistic we can cover the majority of spots well enough.

Another aspect is the animation system. We needed to solve the player rotating around a fixed pivot point (where the bipods are connected to a surface). This is something we wanted to visualize as best as we can given the animation technology available in Arma 3 (given feasible improvements). One example to imagine the challenge is the player standing behind a wall, with the weapon resting on the wall. If the player now aims the weapon up, we want his posture to change


 CommaGroups = Split(Cell, ",")

    For Each CG In CommaGroups

        DashGroups = Split(CG, "-")

        For X = DashGroups(0) To DashGroups(UBound(DashGroups))
            If j = 0 Then j = Split(Cell.Address, "$")(2)

            Rows(j + 1 & ":" & j + 1).Insert Shift:=xlDown
            Cells(j, 9).Value = X

            Range("C" & j + 1 & ":H" & j + 1).Value = Range("C" & j & ":H" & j).Value

     to do something like this in CodeIgniter (to get one row where id=array of one row ($_SESSION['id']

A:

I think you are looking for result_array()
see the manual here
$query = $this->db->query("YOUR QUERY");

foreach ($query->result_array() as $row)
{
   echo $row['title'];
   echo $row['name'];
   echo $row['body'];
}

UPDATE
public function login($user, $pass) // Takeing the username/pass from form
{
    $this->db->where('username', $user);
    $this->db->where('password', md5($pass));

    $query = $this->db->get('korisnici');

    if ($query->num_rows() == 1)
    {
        $_SESSION['id'] = $this->query->row()->id;
        return TRUE;
    }
    else
    {
        return FALSE;
    }
}

public function getData()//Get result of


Gal Gadot to star in Nazi revenge thriller ‘Ruin’

Gal Gadot is in negotiations to join the cast of Nazi revenge thriller “Ruin”. Justin Kurzel, who directed “Assassin’s Creed”, is set to helm the movie, which centers on a former Nazi captain who, as a way of making up for his crimes, hunts down and kills his former team of SS officers in Germany, according to The Hollywood Reporter. It is unclear what role Gadot would play in the movie. Kurzel is also said to be prepping a film about Australian outlaw Ned Kelly.

If sources are to be believed Christian Bale has been offered to play the role of captain but no negotiations have begun yet.Meanwhile, Gadot has the much-awaited sequel of ‘Wonder Woman’ in her pocket for lategive Yet one more aggressive Spotswood team for opposition to worry about.

Drage was named best on floor for his 4-quarter work, although Buntine was instrumental with the midfield.

Jack Cairns was also serviceable in excess of the four quarters through the midfield, when Jeremy Cross presented an abundance of click sprint.

Captaining the side versus Wyndhamvale, ‘Irish’ as is fondly referred to, kicked tree ambitions and was named finest on floor in nearly as good a ship-off as you will notice.

Late in the 2nd quarter, the Woodsmen ongoing to ramp up their effort, and because the siren sounded they ended up however full of operate.

Our Free of charge Youngsters Action Zone will once again be in full pressure to make sure that there is one area click for The complete


line or a Virtual Private Network (VPN) line. Alternatively, telephone companies offer a variety of overlapping discount schedules which could be utilized to minimize costs for a particular transmission. A disadvantage of using such alternate communication services is that a user has to be aware of a multitude of telephone number, access codes, and rate schedules.
Auto-dialers may also be used to reroute calls to a voice carrier based on broad categories, long distance, intra-lata, etc. They are however unselective in that, if a call is long distance, it is routed regardless of the destination. Also, these devices do not reroute if the original target is busy or unavailable. Lastly, these device do not exchange information up to or down from the facility to which they connect nor dothe pickup area, the parcel is transferred to a distribution center. After carrying out a shipping operation and storing the parcel in a warehouse, the parcel is paid out from the warehouse for example on the following day and is transferred on a distribution truck to the destination for delivery service.
If the destination is a distant location, parcels for the same destination are gathered in a departure base of the location from the pickup center. The parcels are loaded on a working truck in the night, and transported through expressways to the arrival base of the destination. The parcels are then sent from the arrival base to a distribution center controlling the destination to store the same in a warehouse. Then, on the following day, the parcels are


an unclear and blurry screen may appear because of the characteristics of liquid crystals. The motion blur may remarkably appear in the motion picture, and a motion picture response time (MPRT) has to be reduced so as to remove the motion blur. A related art scanning backlight driving technology was proposed so as to reduce the MPRT. As shown in FIG. 1, the scanning backlight driving technology provides an effect similar to an impulsive drive of a cathode ray tube by sequentially turning on and off a plurality of light sources Lamp 1 to Lamp n of a backlight unit along a scanning direction of display lines of a liquid crystal display panel, thereby solving the motion blur of the liquid crystal display.
However, the related art scanning backlightetc. 2. A priest; -- so called in contempt or ridicule.

Levitical (le*vĭt"ĭ*k a l) adjective [ Latin Leviticus , Greek Leyitiko`s .] 1. Of or pertaining to a Levite or the Levites. 2. Priestly. " Levitical questions." Milton. 3. Of or pertaining to, or designating, the law contained in the book of Leviticus. Ayliffe.

Levitical degrees , degrees of relationship named in Leviticus, within which marriage is forbidden.

Levitically adverb After the manner of the Levites; in accordance with the levitical law.

Leviticus (-ĭ*kŭs) noun [ See Levitical .] The third canonical book of the Old Testament, containing the laws and regulations relating to the priests and Levites among the Hebrews, or the body of the ceremonial law.

The levity that is fatigued and disgusted with everything of which it is in


name formerly given in Pennsylvania, Maryland, and Virginia to the Spanish real of one eighth of a dollar (or 12½ cents), valued at eleven pence when the dollar was rated at 7s. 6d.

Levy noun [ French levée , from lever to raise. See Lever , and confer Levee .] 1. The act of levying or collecting by authority; as, the levy of troops, taxes, etc.

A levy of all the men left under sixty.

Thirlwall. 2. That which is levied, as an army, force, tribute, etc. " The Irish levies ." Macaulay. 3. (Law) The taking or seizure of property on executions to satisfy judgments, or on warrants for the collection of taxes; a collecting by execution.

Levy in mass [ French levée en masse ], a requisition of all able-bodiedthe land lies for confirmation and approval, and obtains an order of confirmation and approval thereon."
The sale of the property under Pappas' deed to secure debt to Mansell was never confirmed by Mansell in accordance with this statute. There was no error, therefore, in granting summary judgment to Pappas on Mansell's counterclaim for any deficiency on the sale of the property arising from Pappas' obligations under the note and deed to secure debt. See Sockwell v. Pettus, 139 Ga. App. 311 (1) (228 SE2d 343); Marler v. Rockmart Bank, 146 Ga. App. 548 (246 SE2d 731).
Judgment affirmed. Shulman and Carley, JJ., concur.


[Early surgical treatment of bronchopleural fistula after pneumonectomy].
To investigate the method of early surgical treatment of bronchopleural fistula after pneumonectomy. Twelve patients (9 males and 3 females with a mean age of 58.6-/+5.7 years) with bronchopleural fistula after pneumonectomy received a reoperation within 72 h after a definite diagnosis. Empyema was found in none of the 12 cases. Fistula occurred within 4 to 17 days (8 days in average) after the operation. The fistula of the residual main bronchus was resected, and the thoracic cavity was asepticized by flushing. Ten patients were discharged with complete healing. One patient was discharged following open drainage with daily change of the wound dress. One patient died due to multiple organ failure. The hospital stay of the patients ranged from 18 topart of the forfeiture reserved out of the proceeds of the cargo? If the latter be the true construction, then the collector is entitled to a moiety: if the former, he is barred of all claim.
The duty of the collector in superintending the collection of the revenue, and in making seizures for supposed violations of law, is onerous, and full of perplexity. If he seizes any goods, it is at his own peril; and he is condemnable in damages and costs, if it shall turn out, upon the final adjudication, that there was no probable cause for the seizure. As a just reward for his diligence, and a compensation for his risks; at once to stimulate his vigilance and secure his activity; the laws of the United States


to release the collector's share as such; and yet to retain to itself the other part of the forfeiture.
*427 In the present case, it is perfectly clear that the seizure of the Good Friends and her cargo was justifiable, and that they were forfeited for a violation of the non-intercourse acts. This is established, not only by the final decree of condemnation, but by the very terms of the remission granted by the secretary of the treasury. In point of law, no duties, as such, can legally accrue upon the importation of prohibited goods, They are not entitled to entry at the custom house, or to be bonded.
They are, ipso facto, forfeited by the mere act of importation. The Good Friends, then, having arrived in April 1812, longupon the fact, that the act refers to the double duties as a mere mode of ascertaining the amount; and that it is undistinguishable from the case of a reservation of a gross sum.
Upon the whole, the decree of the circuit court refusing the distribution is to be reversed, and the cause remanded to that court with directions to decree to the legal representatives of Allen M'Lane, the collector, one moiety of the double duties, deducting that portion which has been already received by him.
This cause came on to be heard on the transcript of the record from the circuit court of the United States for the district of Delaware, and was argued by counsel; on consideration whereof, this Court is of opinion, that there is error in


legal representative is now entitled to receive as his distributive share of the forfeiture aforesaid one full moiety of the whole sum which has been paid by Stephen Girard according to the act of congress, and the remission by the secretary of the treasury, as in the same statement of facts mentioned. And the said Allen M'Lane being now dead, it is further ordered, adjudged and decreed, that the same full moiety be paid over to his legal representative, now appearing and made a party to these proceedings in this Court, viz. Louis M'Lane, the *430 executor of the last will and testament of the said Allen M'Lane, deceased, as his distributive share accordingly; deducting, however, therefrom, the moiety of the said moiety, which has been decided byof SrF$_2$ and SrF$_2$-Ce crystals was measured by comparing these response to 662 KeV energy to the response of NaI-Tl crystal with known characteristics under the same conditions. The photopeak in pure SrF$_2$ is centered at a pulse height that is 42% of the 662 keV photopeak pulse height in NaI-Tl. Using the NaI-Tl light output of 43000 photons/MeV, this implies that the light output of pure SrF$_2$ is approximately 18000 photons/MeV that is similar to x-ray emission light output (see Table \[table1\]). The full width at half maximum (FWHM) in pure SrF$_2$ of the 662 keV photopeak is 10 %. FWHM of NaI-Tl is 6.7 %, which is consistent with known results given by scintillators database of [@Berkley].

Dependence of SrF$_2$-Ce relative light output versus concentration is demonstrated in the inset


in England at the time.

The castle is a Grade I listed building, and recognised as an internationally important structure. It is also a Scheduled Monument, a "nationally important" historic building and archaeological site which has been given protection against unauthorised change. The earthworks known as "The Rings", thought to be the remains of a 12th-century motte-and-bailey castle built during a siege of Corfe are also scheduled. In 2006, Corfe Castle was the National Trust's tenth most-visited historic house with 173,829 visitors. According to figures released by the Association of Leading Visitor Attractions, the number of visitors in 2010 had risen to nearly 190,000.

Layout

Corfe Castle is roughly triangular and divided into three parts, known as enclosures or wards.

Enclosed in the 11th century, the inner ward contained the castle's keep, alsoURGENT APPEALS

"There is an invisible wall that blocs the "legal" immigration in the Old Continent. The borders of this Fortress are invisible to the major part of citizens, because they are composed by laws, but their result is visible as a Human tragedy".

Marco Rovelli Italian writer

UNITED for Intercultural Action protests against the building of a "Fortress Europe", which leads to the death of desperate people looking for a safe refuge.

Geneva – Tbilisi, June 9th 2008 – The United Nations Committee on the Rights of the Child has just made public its recommendations on the situation on children’s rights in Georgia, noting that it “remains concerned about the information indicating that children continue to be victims of arbitrary detention, police brutality and ill-treatment in detention facilities”.

We are writing to


$A$ cannot be dropped. The algebra $\F_k$ is a trivial counter-example in the several-variable case. We also remark that, in the case where $\textrm{dim}(M/\overline{M^{2}})\,=\,1$, one deduces $\textrm{dim}(\overline{M^{n}}/\overline{M^{n + 1}})\,=\,1$ for all $n$ in  [@12 Proposition 2.3], and so we do not require $\textrm{dim}(\overline{M^{n}}/\overline{M^{n + 1}})\,=\,1$ for all $n$ as a stronger hypothesis, but then we do require $M$ to be non-nilpotent there. Below, we exhibit an easy counter-example to show that the hypothesis that $\textrm{dim}(\overline{M^{n}}/\overline{M^{n +
1}})\,=\,C_{n+k-1,n}$ for all $n\,\in\,{\mbox{$I \hspace{-2.6mm} N$}}$ is not redundant in the proposition above (many thanks to Professor H. G. Dales for calling my attention to this counter-example).

Let $$B\, =\, \F_2 =\, {\mbox{$I \hspace{-2.6mm} C$}}[[X,\,Y]],$$ with the usual Fréchet algebra topology $\tau_c$ and let $J$ be the ideal generated by the element $X^2 -Y^3$. Since $B$ is noetherian  [@17 VII, Corollary p. 139 and Theorem 4[’]{}], all ideals in $B$ are closed by  [@19 Theorem 5], so $J$ is closed. Hence the quotient $A = B/J$ is a noetherian Fréchet algebra, with all the ideals in $A$ closed. Clearly, $M/J$ is the unique maximal ideal in $A$, where $M\,=\,\ker \pi_0\;(0\,=\,\{0,\,0\})$, in $B$. The two elements $X + J$ and $Y + J$ are linearly independent modulo $(M/J)^2$, and so dim$((M/J)/(M/J)^2)\,=\,2$ since $M/M^2\,\cong \,(M/J)/(M/J)^2$. However $(X + J)^2 \,\in
\,(M/J)^3$, so dim$((M/J)^2/(M/J)^3)\,=\,2$ since $XY + J$ and $Y^2 + J$ are linearly independent modulo $(M/J)^3$.

Next, to see that this is a counter-example, we show that $\bigcap
_{n\geq 1}(M/J)^n \,\neq \, J$, the zero element of $A$. To see this, let us start with an


element $g$ of $B$ such that $$g\,\in\,p X^2 + q XY + r Y^2 + M^3 + J,$$ for some $p, \,q,\, r\, \in\,
{\mbox{$I \hspace{-2.6mm} C$}}$, that is, $$g\,\in\,{\mbox{$I \hspace{-2.6mm} C$}}X^2 + {\mbox{$I \hspace{-2.6mm} C$}}XY + {\mbox{$I \hspace{-2.6mm} C$}}Y^2 + M^3 + J$$ and suppose that $g\,\in\,M^4 + J$. Then $$g\,\in\,(X^2 - Y^3)(a + b X +c Y) + M^4,$$ for some $a, b, c \in {\mbox{$I \hspace{-2.6mm} C$}}$ because all other terms in $J\,=\,(X^2 - Y^3)B$ are in $M^4$. Thus we can see that there exist $a_1, b_1, c_1 \in {\mbox{$I \hspace{-2.6mm} C$}}$ such that $$p X^2 + q XY + r Y^2 = (X^2 - Y^3)(a_1 + b_1 X + c_1 Y) + M^3.$$ Now, equating the coefficients of $XY$ and $Y^2$, we see that $q= r =
0$, and, equating the coefficients of $X^2$, we see that $p =
a_1$, and then, equate the coefficients of $Y^3$ to see that $0 =
a_1$. Thus $p = 0$. We conclude that $M^3 + J\,=\,M^4 + J$. One can generalize this idea to see that $M^n + J\,=\,M^{n+1} + J$ for each $n \geq 3$, the only element of $B$ that belongs to $M^n + J$ is actually in $M^{n +1} + J$. Thus we conclude that $M^3 +
J\,=\,M^n + J $ for each $n \geq 3$, and so $\bigcap _{n\geq
1}(M/J)^n = (M/J)^3\,\neq\,J$.

Fréchet algebras of power series in $\F_k$.
===========================================

We now turn to the problem of describing [*all*]{} those commutative Fréchet algebras which may be continuously embedded in $\F_k$ in such a way that they contain the polynomials


\overline{M_m^{\mid J\mid}}$.

Next, for each $m\,\in\,{\mbox{$I \hspace{-2.6mm} N$}}$, one shows that $p_m$ is closable on $A$ by noticing that the inclusion map $(A,\,p_m) \,\hookrightarrow
\,\F_k$ can be extended to a continuous homomorphism $\phi : A_m
\rightarrow \,\F_k$. So $x_n \rightarrow x$ in $(\F_k,\,\tau_c)$, and hence $p_m(x_n) \rightarrow 0$.

Then one shows that $\phi$ is, indeed, injective, and so $A_m$ is a Banach algebra of power series in $\F_k$ for each $m$. In particular, $A$ satisfies Loy’s condition (E), by the remark following Corollary  \[Corollary 3.2\_BP\].

Automatic continuity and uniqueness of\
topology, and open questions.
=======================================

We now turn to establish that every FrAPS in $\F_k$ has a unique Fréchet topology. By  [@9 Theorem 1], it is clear that every FrAPS $A$ in $\F_k$ satisfying Loy’s condition (E) has a unique Fréchet topology. Since a Beurling-Fréchet algebrainspiration. This forum—literally a creative exchange—is for sharing your Ghost Ranch moments; painting and photography explorations, tips, details of the endeavor, profound moments, challenges and of course your work.

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If you do not choose to be part of the Creative Exchange, bypass the donation option, and still want to paint, photograph or film at Ghost Ranch, please refer to the Commercial Use section of this policy below.

Special Event & Portrait


per person fee will be due and payable at the front desk on the day of your photo shoot.

Commercial Filming & Photography

For legal issues it must be stated that Ghost Ranch Education & Retreat Center is private property and express permission is required for any filming, photography or special project on Ghost Ranch-owned lands (interior & exterior) by:

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Commercial photography and filming at Ghost Ranch is defined as images or footage created of and at the Ranch thatManagement of childhood diarrhea and use of oral rehydration salts in a suburban West African community.
In a household survey in Guinea-Bissau, 319 episodes of diarrhea in children were followed by interviews every second day with the aim of investigating perceived morbidity and subsequent actions taken. The majority of the mothers had good knowledge of oral rehydration salts (ORS). However, only 58% of the episodes were treated with ORS and the amount given was insufficient. Mothers with no knowledge of ORS did not use it during the observed attack of diarrhea regardless of contact with a health center, which suggests that maternal knowledge is an important determinant of whether health personnel provide ORS. Children with diarrhea considered to be caused by teething were less likely to receive ORS in


      $answer[$i[0]][] = $val;
                break;
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        case "t" :
            $b = substr($var, 1);
       breakthrough in preserving our natural resources and protecting water quality,” said Governor Northam. “Our effort will ensure we are disposing of coal ash in the safest, most environmentally-responsible way, and I want to recognize the General Assembly and members of my team for coming together around a solution.”

"I live near the Appomattox River and know how important it is to protect our waterways,” said Speaker of the House Kirk Cox (R-Colonial Heights) "This is a responsible, middle-ground approach that will minimize truck traffic in communities close to these power stations while still protecting our rivers, Chesapeake Bay tributaries, and our drinking water."

The plan calls on power companies to recycle at least 25 percent of the coal ash they currently store in unlined pits near power plants. The material


the Chesapeake Bay," said Rebecca Tomazin, Executive Director of the Chesapeake Bay Foundation Virginia.

Multiple lawmakers in both the House of Delegates and Senate are carrying legislation related to the plan. Northam said when they reach his desk, he plans to sign them into law.

Multiple leaders and elected officials cited the 2014 coal ash spill by Duke Energy that resulted in millions of gallons of dark sludge containing coal ash pouring into the Dan River in North Carolina as the type of disaster this plan would help avoid.which is integrated into a 10 μm wide passive waveguide (Fig. [1a](#Fig1){ref-type="fig"}). This design has a simple geometry which couples guided light into free space and transforms the beam divergence in the y-z plane (along θ). The grating outcoupler is connected to the SGDFB laser via a linear taper of the waveguide width from 5 to 10 μm (50 μm length), followed by a small spacer and a linear taper of the upper waveguide cladding width from 10 to 0 μm (180 μm length). The purpose of the taper is to transform the waveguide mode gradually in order to reduce reflections when light transitions between the active part of the device and the grating outcoupler region. In practice, the minimum taper width was 2 μm, limited by the fabrication method employed (see Methods). After


diffraction. The grating takes the form of circular arcs designed to match the phase front of the input beam. The benefit of this technique is that it provides a compact means to expand the output aperture laterally, which significantly reduces the output beam divergence. The arc origin should be placed near the end of the waveguide cladding taper, which in this case extends 90 μm from the end of the 10 μm waveguide. An additional feature of this architecture is the incorporation of a grating heater, which is simply two metal contacts on either side of the grating. This heater can be used to adjust the output angle for a given input beam wavelength. A top view of the fabricated cladding taper, grating region, and heater contacts is shown inMain menu

Tag Archives: food truck

With any craze, there comes a point when you need to stop and ask yourself, Why am I doing this again? For example, everyone in America standing in line in the hot, hot sun or the freezing cold for a measly cupcake should be asking themselves, Is this really worth 45 minutes of my life? Meanwhile, I am asking myself what is so great, really, about food trucks?

I love the idea of food trucks. I walk up to a line of trucks and feel downright giddy. I’m a kid in a candy shop with all these promising choices. I have but one thought and it is,

But obviously I can’t. So after careful deliberation I pick a truck and get in line. But as I’m


waiting, euphoria wears off and reality sets in. I start to realize, Hmm, standing outside a running truck inhaling exhaust fumes for ten minutes has really curbed my appetite and has in fact made me quite nauseous.

And then I look at the prices and think, Why does this cost ten dollars again? There’s no shelter from the elements, no place to sit and eat, no ambience, no service, and often no utensils or napkins. There is literally just the food. So without all that overhead to incorporate into the price, why is my lunch still so expensive? I thought the trade-off of eating out of the back of a truck would be that it cost…like…a dollar.

Why would I expect otherwise? Why would food taste better just for havingof love.

love relationships have an important place in our lives and it is important for the care of these relationships in order to get pleasure from life. however differences that normally arise in the relationships that can create jobs suffer take the magic if our relations. if you are having problems such as unnecessary discussions with the lover, lack of communication and understanding. for your happy life you never think it is a matter of minor or huge, treat as a gift and refers to our love problem specialist astrologer. the problems are in our life forever arising as a result of which tend to keep the space between incomprehension and our remover problems, love specialist problem astrologer carry out the distance of each of you and one


2010 South African study consisting of 215 epidemic KS patients reported roughly a 20% increase in one-year survival rates for patients receiving cART versus those who were not\[[@pone.0147636.ref009]\]. Furthermore, survival was about 30% lower for those diagnosed at later stages of the disease versus those diagnosed in earlier stages. A tool for the timely diagnosis of KS in resource-limited settings is needed and could help to decrease KS mortality.

Diagnosis of KS is difficult. KSHV detection by serological assay is impractical, as much of sub-Saharan Africa has a KSHV seroprevalence rate above 50%\[[@pone.0147636.ref001],[@pone.0147636.ref010]\] (KSHV infection is necessary for KS formation, but is not sufficient). KSHV viremia is also inadequate for diagnosis because the virus can be found in the blood of patients without KS, and not all individuals withKS will have viremia\[[@pone.0147636.ref011],[@pone.0147636.ref012]\]. Diagnosis by pathology following biopsy is possible, but is limited without immunohistochemistry to detect viral protein: a 2012 study found that pathology performed in Uganda and Kenya achieved only 72% sensitivity and 84% specificity for KS diagnosis when US pathology that included immunohistochemistry was taken as the gold standard\[[@pone.0147636.ref013]\]. A highly specific alternative to serology and pathology exists in the form of nucleic acid diagnostics. In 1994 it was discovered that DNA subfragments in the KSHV episome were amplified only in biopsy samples that were known by microscopy to be positive for KS\[[@pone.0147636.ref014]\].

The polymerase chain reaction (PCR) achieves amplification of specific nucleic acids by cycling DNA through three temperature zones. An example of a successful PCR-based diagnostic system is the GeneXpert, which has been


(important because real biopsy samples will contain similar PCR inhibitors), nor had we presented a device suitable for deployment.

We now present the KS-Detect: an integrated solar thermal PCR system suitable for field deployment in resource-limited settings and targeted towards the diagnosis of Kaposi's sarcoma. In this paper, we introduce the KS-Detect system, describe how to operate it, and validate its ability as a diagnostic tool using DNA from pseudo-biopsy samples extracted using a simplified methodology and not requiring complex laboratory equipment. We show that the KS-Detect successfully amplifies samples with KSHV+ concentrations similar to those of real human biopsy samples positive for KS, report sensitivity and specificity results, and comment on critical engineering considerations for future solar thermal PCR systems.

The KS-Detect system {#sec002}
--------------------

KS-Detect is a fully contained, portableconcentrations. We conclude that SYBR green can only be recommended for use in the KS-Detect if non-specific amplification is minimal (achievable if there are optimal heating conditions, such as shown in [Fig 4C](#pone.0147636.g004){ref-type="fig"}); otherwise, a specific fluorescent marker should be implemented.

![Effect of non-specific amplification on SYBR analysis.\
(A) SYBR green dye fluorescent intensities with (B) corresponding gel electrophoresis images. Amplification was performed by the KS-Detect system on pseudo-biopsy samples. Some amplification sets (B, top) showed minimal amounts of non-specific amplification (or smearing), while other sets had consistent (B, middle) or variable (B, bottom) amounts across different KSHV+ cell concentrations. For all three gel electrophoresis images, the order of the samples in each well is: DNA ladder, 100%, 10%, 1%, and 0% KSHV+ cell concentrations.](pone.0147636.g005){#pone.0147636.g005}

Future system improvements {#sec009}
--------------------------

Technical improvements could


system and resources.

What are containers?

The industry standard today is to use Virtual Machines (VMs) to run software applications. VMs run applications inside a guest Operating System, which runs on virtual hardware powered by the server’s host OS.

VMs are great at providing full process isolation for applications: there are very few ways a problem in the host operating system can affect the software running in the guest operating system, and vice-versa. But this isolation comes at great cost — the computational overhead spent virtualizing hardware for a guest OS to use is substantial.

Containers take a different approach: by leveraging the low-level mechanics of the host operating system, containers provide most of the isolation of virtual machines at a fraction of the computing power.

Why use containers?

Containers offer a logical packagingplease go ahead and clone the repository locally like so -

$ git clone https://github.com/prakhar1989/docker-curriculum.git $ cd docker-curriculum/flask-app

This should be cloned on the machine where you are running the docker commands and not inside a docker container.

The next step now is to create an image with this web app. As mentioned above, all user images are based on a base image. Since our application is written in Python, the base image we're going to use will be Python 3.

Dockerfile

A Dockerfile is a simple text file that contains a list of commands that the Docker client calls while creating an image. It's a simple way to automate the image creation process. The best part is that the commands you write in a Dockerfile are almost identical to their equivalent Linux


single-container Docker deployments which is what we'll use to deploy our app. Although EB has a very intuitive CLI, it does require some setup, and to keep things simple we'll use the web UI to launch our application.

To follow along, you need a functioning AWS account. If you haven't already, please go ahead and do that now - you will need to enter your credit card information. But don't worry, it's free and anything we do in this tutorial will also be free! Let's get started.

Here are the steps:

Login to your AWS console.

Click on Elastic Beanstalk. It will be in the compute section on the top left. Alternatively, you can access the Elastic Beanstalk console.

Click on "Create New Application" in the top right

Give your app a memorable (but(hopefully), let's think of how we can Dockerize the app. We can see that the application consists of a Flask backend server and an Elasticsearch service. A natural way to split this app would be to have two containers - one running the Flask process and another running the Elasticsearch (ES) process. That way if our app becomes popular, we can scale it by adding more containers depending on where the bottleneck lies.

Great, so we need two containers. That shouldn't be hard right? We've already built our own Flask container in the previous section. And for Elasticsearch, let's see if we can find something on the hub.

$ docker search elasticsearch NAME DESCRIPTION STARS OFFICIAL AUTOMATED elasticsearch Elasticsearch is a powerful open source se... 697 [OK] itzg/elasticsearch Provides an


easily configurable Elasticsea... 17 [OK] tutum/elasticsearch Elasticsearch image - listens in port 9200. 15 [OK] barnybug/elasticsearch Latest Elasticsearch 1.7.2 and previous re... 15 [OK] digitalwonderland/elasticsearch Latest Elasticsearch with Marvel & Kibana 12 [OK] monsantoco/elasticsearch ElasticSearch Docker image 9 [OK]

Quite unsurprisingly, there exists an officially supported image for Elasticsearch. To get ES running, we can simply use docker run and have a single-node ES container running locally within no time.

Note: Elastic, the company behind Elasticsearch, maintains its own registry for Elastic products. It's recommended to use the images from that registry if you plan to use Elasticsearch.

Let's first pull the image

$ docker pull docker.elastic.co/elasticsearch/elasticsearch:6.3.2

and then run it in development mode by specifying ports and setting an environment variable that configures the Elasticsearch cluster to run as a single-node.

$ docker- /opt/flask-app . This is where our code will reside. We also set this as our working directory, so that the following commands will be run in the context of this location. Now that our system-wide dependencies are installed, we get around to installing app-specific ones. First off we tackle Node by installing the packages from npm and running the build command as defined in our package.json file. We finish the file off by installing the Python packages, exposing the port and defining the CMD to run as we did in the last section.

Finally, we can go ahead, build the image and run the container (replace prakhar1989 with your username below).

$ docker build -t prakhar1989/foodtrucks-web .

In the first run, this will take some time as the Docker client


will download the ubuntu image, run all the commands and prepare your image. Re-running docker build after any subsequent changes you make to the application code will almost be instantaneous. Now let's try running our app.

$ docker run -P --rm prakhar1989/foodtrucks-web Unable to connect to ES. Retying in 5 secs... Unable to connect to ES. Retying in 5 secs... Unable to connect to ES. Retying in 5 secs... Out of retries. Bailing out...

Oops! Our flask app was unable to run since it was unable to connect to Elasticsearch. How do we tell one container about the other container and get them to talk to each other? The answer lies in the next section.

Docker Network

Before we talk about the features Docker provides especially to deal with such scenarios, let's: "5c417a2fc6b13d8ec97b76bbd54aaf3ee2d48f328c3f7279ee335174fbb4d6bb" , "MacAddress" : "02:42:ac:11:00:02" , "IPv4Address" : "172.17.0.2/16" , "IPv6Address" : "" } }, "Options" : { "com.docker.network.bridge.default_bridge" : "true" , "com.docker.network.bridge.enable_icc" : "true" , "com.docker.network.bridge.enable_ip_masquerade" : "true" , "com.docker.network.bridge.host_binding_ipv4" : "0.0.0.0" , "com.docker.network.bridge.name" : "docker0" , "com.docker.network.driver.mtu" : "1500" }, "Labels" : {} } ]

You can see that our container 277451c15ec1 is listed under the Containers section in the output. What we also see is the IP address this container has been allotted - 172.17.0.2 . Is this the IP address that we're looking for? Let's find out by running our flask container and trying to access this IP.

$ docker run -it --rm prakhar1989/foodtrucks-web bash root@35180ccc206a:/opt/flask-app { "name" : "Jane Foster" , "cluster_name" : "elasticsearch" , "version" : { "number" : "2.1.1" , "build_hash" :


app.py changes. Replace the web portion of the docker-compose.yml file like so:

version: "3" services: es: image: docker.elastic.co/elasticsearch/elasticsearch: 6.3 .2 container_name: es environment: - discovery.type=single-node ports: - 9200 : 9200 volumes: - esdata1: /usr/share/elasticsearch/data web: build: . command: python3 app.py environment: - DEBUG= True depends_on: - es ports: - "5000:5000" volumes: - ./flask-app:/opt/flask-app volumes: esdata1: driver: local

With that change (diff), let's stop and start the containers.

$ docker-compose down -v Stopping foodtrucks_web_1 ... done Stopping es ... done Removing foodtrucks_web_1 ... done Removing es ... done Removing network foodtrucks_default Removing volume foodtrucks_esdata1 $ docker-compose up -d Creating network "foodtrucks_default" with the default driver Creating volume "foodtrucks_esdata1" with local driver Creating es ... done Creating foodtrucks_web_1 ... done

As a final step, lets make the change in app.py by adding a newconstructed in a variety of ways:

Alists are probably an 80% solution, which is plenty for most situations, but
FSet’s maps are quite nice and give you that O(log n) lookup and update time
complexity with the structural sharing that we’ve grown to love. I’ve found
them as useful as Clojure’s hashmaps. Like the other collections, there’s a
function EMPTY-MAP that’s self explanatory and a macro MAP for constructing
larger maps:

4. Conclusion w/bonus Feature

I only scratched the surface with the FSet library. There are more functions
than the ones I listed and some of the ones I describe actually return multiple
values, for example to signify if a key is present in case you are storing NIL
as values, etc. I recommend the FSet
Tutorial for more
details.

Lists in Common Lisp are really quite versatile and can approximate most


The effect of acid drinking water on rumen protozoa in the blesbok (Damaliscus dorcas phillipsi).
Rumen contents were collected from ten adult female blesbok, five from a mine area with only acid drinking water available and five from a control group consuming normal, non-polluted drinking water. The mean concentration of total protozoa in the normal water group was almost double that in the acid drinking water group, 24.9 x 10(3) versus 14.7 x 10(3). Percent of Entodinium was higher and Diplodinium lower in those animals drinking the acid water. The number of different protozoa species present in animals from both locations was fairly similar. Diplodinium bubalidis, Ostracodinium gracile and Diplodinium consors were present in the highest percentage in the normal water group, 18.8, 18.4 and 17.7 %, respectively. Theand carrying out interpolations. However, the code for this step is not provided. I have been unable to replicate Mann’s selection of 1082 gridcells using the criteria reported in the Corrigendum SI. The code for making this selection is not provided.The file globe-1902.dat looks like it might be the same as the archived file FTP/MANNETAL98/INSTRUMENTAL/gridpoints.loc, but this is only a guess.

2. The file globe-1854.dat is a roster of latitude/longiture gridcell identifiers. It is not archived anywhere.

3. The file globe-1854.mask presumably identified the 219 gridcells said to have “nearly continuous” records from 1854 and illustrated in a diagram in MBH98, but it is not archived anywhere.

5-7. The files glb-long-all*.int, glb-long-cold*.int and glb-long-warm*.int are presumably derived from the file FTP/MANNETAL98/INSTRUMENTAL/anomalies-new mentioned above. However, they are not archived in this form.The