2092667121.
3102092667120.8
What is -1390 plus 14334748145?
14334746755
What is -54.1466201 plus 0.1462?
-54.0004201
Add together -26033623700.292 and 0.2.
-26033623700.092
What is 382.2 less than -775168551?
-775168933.2
Work out 6.168436 + 50.969.
57.137436
Add together 111010072 and 5260.
111015332
Put together 8616403828932 and 6.2.
8616403828938.2
Calculate -318.4 - 1.0210992.
-319.4210992
Total of -36.5 and 36088854403.
36088854366.5
Work out -2.817 - 0.017357749.
-2.834357749
Work out 49.222 - 681801.923.
-681752.701
Put together -9 and -644889.346303.
-644898.346303
Work out 105216255 + -23732.
105192523
Put together -5.649 and -591208.133.
-591213.782
Add together 5892403305 and 29.37.
5892403334.37
Total of -589445224826 and -0.041.
-589445224826.041
-116922013652 + 5.5
-116922013646.5
Add -208.403 and -0.247485648.
-208.650485648
Subtract 0.9106912 from -75486.
-75486.9106912
Total of 0.3213 and 4940.163632.
4940.484932
Put together -0.870927 and 256713.
256712.129073
What is 0.01107616923 less than 4203?
4202.98892383077
What is 178606146.8993 plus 0.06?
178606146.9593
Put together 202372444 and 3732.
202376176
What is the difference between -788 and -856234728599?
856234727811
What is the distance between -0.5 and 5434068084?
5434068084.5
Add together 0.456855 and 36870.9.
36871.356855
What is 10753528274608 + 3?
10753528274611
Work out -31510095.8005 + -23.14.
-31510118.9405
Add together -0.062889 and -262504.
-262504.062889
Calculate -110315 + 0.360272132.
-110314.639727868
What isQ:

Sentence capitalization exception

I have this script which capitalizes the first letter of each sentence:
String.prototype.capitalize = function() {
    return this.replace(/.+?[\.\?\!](\s|$)/g, function (txt) {
        return txt.charAt(0).toUpperCase() + txt.slice(1);
    });
};

I want to add an exception: the first word of the sentence after ., ?, and ! characters should not be capitalized if the character is preceded by an xy word.
In my case from capitalization of string xy. is not correct. will be Capitalization of string xy. Is not correct.
I want as a result: Capitalization of string xy. is not correct.
Any ideas?

A:

Since Javascript doesn't support lookbehinds, you'll have a much easier time going through exactly the function you've written and then arbitrarily correcting the mistakenly capitalized bits back to


are quite really bad for animation, I rather use this one but I think youtube wouldn't like it. I would be eternally grateful if possible.

That's what i meant by providing the blender files o.o. I think a sfm model can be ported to gmod by decompiling it first, but that sometimes may break the model. By using the original blender file, you already have it decompiled (and not broken), so it should be easier to port it to Gmod. Ooooooor just download this sfm model and decompile it, whatever lol

To work in the Garry's Mod, she needs collision model in blender (.qc file), can you make this? How made this: find in youtube,google. Please! I would be very grateful!
I can give you a link to video on YouTubeSunday night’s doubles victory at Queen’s Clubhas brought Andy Murray full circle. As he admitted in his autobiography, his first tennis memory was of playing doubles for the Dunblane third team at the age of eight.

“My partner was a 51-year-old architect called John Clark,” Murray recalled. “After a couple of points, I went up to him and said: ‘You’re standing a bit close to the net. You should stand back a bit because I want to serve and volley and you’ll get lobbed’.”

The story is a reminder of why Murray has slotted so neatly into the doubles format. As soon as he could hold a racket, his mother Judy prioritised competition over repetitive drilling. His tennis IQ was prodigious from an early age, as he befuddled junior hopefuls


according to the International Organization for Migration. So far, 2016 is looking as bad if not worse. The IOM has so far documented nearly 2,920 deaths, the vast majority of them from African nations.

Operation Sophia is also aimed at deterring migrants from coming by shutting down the smuggling routes. Europe absorbed more than a million irregular migrants in 2015, a five-fold increase compared to 2014.

But in a report released Wednesday, Human Rights Watch said the effort "risks condemning migrants and asylum-seekers to violent abuse."

"It's unacceptable to save or intercept people at sea and then send them back for abuse on land," said Judith Sunderland, associate Europe and Central Asia director at Human Rights Watch. "The EU — soon perhaps with NATO's help — is basically outsourcing the dirtybecause the problem has become so well-known.

A 26-year-old Ivorian woman interviewed by Human Rights Watch said she was detained in June and July 2015 at an official facility in the Libyan city of Tajoura. She spoke of being forced to give oral sex to a Libyan guard almost daily. A failed attempt to escape by a group of women only led to further sexual violence.

"Seven girls got away but they caught the rest of us," she said. "The guards stripped one of us, a Nigerian girl, and raped her in front of us in the courtyard."

On the morning of June 26, the Aquarius pulled along the Sicilian coast and into the port of Messina. The migrants are given medical checks and registered and housed in so-called 'hotspot' migration


I in 1914. On this year’s Armistice Day in London, a massive work of art dedicated to commonwealth servicemen and women lost a century ago reached its conclusion. The evolving installation, titled “Blood Swept Lands and Seas of Red”, began back on July 17, with the placing of a single ceramic poppy in the moat of the Tower of London. (The Atlantic)

When It’s Bad to Have Good Choices: It may not surprise you to learn that healthy, well-fed people in affluent countries are often unhappy and anxious. But it did startle Zbigniew Lipowski when he came to a full realization of this fact. He had emigrated to North America from Dublin, in 1955, and, in the mid-nineteen-sixties, was put in charge of the psychiatry practices at two Montreala maverick doctor gave him a miracle too fantastic to believe. Richard got a face transplant, a new life, and a new set of burdens too strange to predict. What’s it like to live with a face that wasn’t yours—and that may never quite be? (GQ)

14 Portraits Of College Grads Living At Home: It used to be shameful to move back home after college–a sign of personal failure. Now, because of rising student debts and a sub-stellar economy, it’s a common reality. That doesn’t make it any less weird for a liberated young adult to move back home and experience the childhood delights of family dinners and curfews all over again. Photographer Damon Casarez captures this odd spectacle in Boomerang Kids, a photographic collection of college grads who


another 4096 bytes from the kernel buffer into the URB buffer, submit the URB again to the USB controller and forward the kernel buffer pointer by 4096 bytes.
But what I don't understand is, how come they be so sure that by the time a URB trasfer is finished, there are 4096 bytes of new data in the kernel buffer? The new data amount in the kernel buffer might be smaller than 4096 bytes? Then why does it always update the buffer pointer by 4096 bytes. I think there should be some of knowing how many new bytes are in the kernel buffer and the driver should only  update by that amount or may be I misunderstood something? Any suggestion or guideline is appreciable.

A:

These USB audio driversComparison of standard and modified transvenous techniques for complex pacemaker lead extractions in the context of cardiac implantable electronic device-related infections: a 10-year experience.
Complete lead extraction of cardiac implantable electronic devices (CIED) for device-related infections remains a complex procedure for chronically implantated leads. We present data from a single-centre registry of consecutive patients with extractions over 10 years. Patients were identified from the centre's electronic database with CIED-related infections who underwent lead extraction using either the standard technique and equipment or a modified innovative transvenous lead technique extraction using an ablation catheter. Of 151 patients with CIED-related infections, not responding to simple manual traction to effect lead extraction, average age 65 ± 8 years (range 45-82), 64% being male, 75 underwent standard (S) extraction, and 76 underwent modified


to a substantial reduction of the growth rate and number of surviving cells after 24 H or 48 H in culture (Figure [1A](#F1){ref-type="fig"}). The strongest deleterious effects were observed culturing the cells with either LPS alone or both IFN and LPS, resulting in the recovery of only approximatively 20% viable cells as estimated by MTT assay (or trypan blue test) at 24 H, and 13% at 48 H. IFN alone induced less cytoxicity with 54% and 50% viable cells recovered at 24 H and 48 H respectively (Figure [1A](#F1){ref-type="fig"}). The surviving cells subsequently recovered an *in vitro* growth rate comparable to untreated parental RAW 264.7 cells in culture (not shown). Additional experiments indicated however that those surviving activated macrophages had acquired peculiar resistance capacity to exogenous oxydative and24 hours after LPS stimulation of RAW 264.7 cells, compared to basal level in unstimulated cells, (but not after IFN~50~ or LPS~5~/IFN~50~ treatments), returning to basal level at 48 H. A sharp seven fold increased SOD activity was observed at 6 H in RAW 264.7 cells stimulated with IFN~50~ and IFN~50~/LPS~5~, which was not observed at any other time point, nor with the other stimulation protocols. No significant changes in Gpx activity was observed in stimulated cells.

![**Transcriptional modulation of important redox proteins in RAW 264.7 either undifferentiated, or differentiated cells**. RAW 264.7 cells were cultured (2.5 × 10^6^ cells/well) in medium, or medium supplemented with either LPS (5 μg/ml -- hached boxes), or IFN-γ (50 U/ml -- green boxes) or a mixture of IFN-γ (50 U/ml) + LPS


Q:

Select N unique rows randomly while excluding 1 specific row (in SQLite DB)

I need to select x unique rows randomly from a table with n rows, while excluding 1 specific row. (x is small, 3 for example) This can be done in several queries if needed and I can also compute anything in programming language (Java). The one important thing is that it must be done faster than O(n), consuming O(x) memory and indefinite looping (retrying) is also undesirable.
Probability of selection should be equal for all rows (except the one which is excluded, of course)
Example:
| id | some data |
|————|———————————|
|  1 |     …     |
|  2 |     …     |
|  3phrase I've plucked from a moderately famous (and quite controversial) polemic against the Scrum methodology. It describes the way that some organisations infantilise developers and treat them with the suspicion normally reserved for non-professional workers.
Whatever you think about the 'harms' of making developers' work entirely transparent (and you may not agree it is actually a harm), many individuals value their autonomy and their ability to work alone, trusted to do the right thing. It's an important psychological need, and to force developers into pairing (as I've seen happen in at least one shop) will leave employees dismayed, upset and alienated.
5 - Some developers just don't play nicely in pairs.
Some people won't or can't conduct themselves appropriately in a paired environment. They may have bad hygiene, poor working habits,


can have personal benefits, they are not the reason or end of any development methodology. (Full time) pair programming, for example, also stops you from slacking, surfing etc, you have to justify your pauses to your partner.
Your (rotating) partner will be the best surveillance camera: work intensity increases.
Or, by distributing knowledge the individual becomes less risky to the company (e.g. cannot leave the company with essential knowledge) and has less "bargaining chips".
I'm sure you find more points by reading affirmative articles more critically from YOUR real situation/standpoint in the company rather than from the perspective of your manager.
Almost all methodologies are written from the manager's perspective.

Musa land is defined as Area A land, while the remaining 98.3% is defined as Area C.

Since 1995, control over the tomb itself has been allocated to the Palestinian National Authority.

Descriptions

The journalist Philip Perceval Graves, the brother of the poet and mythographer Robert Graves, gave a vivid description of the colorful re-entry of worshipers back from the countryside into Jerusalem as they passed through the Jaffa gates:

As they entered the old city, the enthusiasm of the crowds reached its highest intensity. Men with the set blank stare of extreme excitement danced round and round, bareheaded, their long locks flying wildly as they revolved. . . Last came the green banner of Hebron surrounded by a guard of ten wiry swordsmen. Proudly they walked with their flag, until they


dollars, including people paying to keep their tent on the land. In addition, 23% have no access to bathrooms. Less than 1% of those refugees have no access to toilets, as 55% used flush latrines and 27% used improved pit latrines.

No formal Syrian refugee camps exists in Lebanon. There are 12 pre-existing formal Palestinian refugee camps in Lebanon managed by UNRWA. While the Lebanese, Syrian, and Palestinian communities, as well as responsibilities for them, are to some extent separated, some Syrians nevertheless live in those camps, at least in the short term. However, essentially no estimates of their number are known.

Iraq

There are 240,000 registered Syrian refugees in Iraq, 90,000 of whom reside in camps managed by UNHCR, IRC and the Directorate of Health.
All the ten Syrian refugee campslost- work usually guides my life so without work I was lost for a little bit- so I knew I needed to recenter and ground myself- I got on my daily exercise routine + a little meditation and a lot of time spent alone to process my thoughts as I had a big back log I needed to go through-

Since I don't drive- my only local escape from the increasingly scummy San Jose streets is the Highway 17 Express bus that goes over the hill to Santa Cruz- the closest beach town-

Since I don't use a mobile phone if I need to communicate magically to humans I try to get on wifi to use google voice or find a pay phone

The payphone at the bus stop was in


myself, 'Don't fall down.'" She ultimately sustained injuries to her head, chest, and upper body, but escaped with her life and sought out a police officer.

Warr was able to return home that evening, but she says she has serious concerns about how the Houston Police Department addressed her case. "I don't feel like they took it very seriously," she told About. "I didn't feel like I was being comforted like a woman who was attacked."

In April, Hoston's Mayor Annise Parker released a draft of a sweeping Houston Equal Rights Ordinance, also known as HERO, that protects anyone living, working in, or visiting the city from housing, public accommodations, and employment discrimination based on, among other characteristics, their gender identity. However, the law has been delayed by detractors untilfilling in gaps. Most
researchers seem to think they are targeting gaps, but (in my field at least)
literature reviews are typically not detailed enough to truly know where the
cutting edge is. Researchers often end up reinventing the wheel.

I also have extended existing data by taking advantage of the properties of a
special case to get some information most would consider very difficult to
obtain. (Basically, I use a proxy which has a known strong correlation to the
quantity of interest in the special case. It doesn't work outside of the
special case.) Most avoid getting this information because either the
researcher chooses a bad proxy, or knows how to get the information more
directly but dislikes the method they know (because it would be a lot of
work).

I supplement existing data with sanity checks on existing


election campaign and, more recently, in confirmation hearings for President Donald Trump’s key foreign-policy and national-security nominees. That said, public discussion before and after the November election has also exposed sharp differences over U.S. policy toward Russia and the assessments of U.S. and Russian interests, objectives and values that shape Washington’s choices. This volume seeks to contribute to that debate by exploring U.S. options in pursuing President Trump’s stated intent to engage with Moscow

Abstract:
On October 10, 2018, the US Department of Homeland Security (DHS) issued its long-anticipated proposed rule on inadmissibility on public charge grounds.[1] The rule seeks to “better ensure” that applicants for admission to the United States as immigrants (permanent residents) and nonimmigrants (temporary residents),[2] as well as applicants for adjustment to lawful permanent resident (LPR)gas, and the advent of US liquefied natural gas exports to the world. Just as important has been the emerging competition from renewable fuels. Indeed, questions are now arising about whether Europe needs new investments in natural gas infrastructure or if those investments would become stranded assets. However, suggesting that the EU does not need new investments risks underestimating the role—or the potential role—natural gas plays in various sectors of Europe’s energy economy, including industry, transportation, and commercial and residential usage.

Abstract:
Climate change is a serious threat to global progress and stability. Actions to reduce greenhouse gas (GHG) emissions and stabilize global temperatures can avoid impacts of climate change on human health, the economy, national security, and the environment. But without a strong federal-level climate policy response from the


consolation, while TJ Leon (20.63) and Kyle Owens (20.64) claimed spots in the C-final.

Sophomore Tommy McKee provided the other big highlight of the morning for the Auburn men, knocking more than 14 seconds off his previous personal best in the 500 free with an NCAA `B' cut time of 4:24.09 to earn a spot in tonight's championship final. It's the best time this season by an Auburn swimmer and ranks him in the nation's top 30 so far this year. Junior Zane Grothe put together a nice morning swim of 4:24.25 to earn a spot in the consolation final, while Jordan Jones (4:32.29), Steyn Funk (4:34.27), Sam Parker (4:34.68) and Antton Haramboure (4:34.78) all posted season-best times.

Owens was the other Auburn swimmer to earn a spot in anecessitating the intravenous administration of ephedrine occurred in three patients in the BIS group and five patients in the non-BIS group. No patients required a blood transfusion during surgery.

Total doses of anesthetic and analgesic drugs administered
----------------------------------------------------------

The total doses of propofol and remifentanil administered during general anesthesia were significantly lower in the BIS group compared with the non-BIS group (P\<0.001) ([Table 2](#t2-medscimonit-24-7785){ref-type="table"}). However, there were no significant differences between the two groups for the total doses of flurbiprofen or sufentanil given for postoperative analgesia ([Table 2](#t2-medscimonit-24-7785){ref-type="table"}).

Attention network function
--------------------------

There were no significant differences between the two groups in pre-operative attention network efficiencies. Both the BIS group and non-BIS group exhibited significant impairment in alerting, orienting, and executive control at postoperative day 1, when compared with the corresponding pre-operative values (all


reported that patients with BIS monitoring during anesthesia had a lower rate of POCD at three months following surgery (10.2%) when compared with patients without BIS monitoring during anesthesia (14.7%) \[[@b17-medscimonit-24-7785]\]. A meta-analysis of clinical studies also concluded that BIS monitoring reduced the incidence of POCD at three months after surgery \[[@b18-medscimonit-24-7785]\].

The finding from the present study, that age was strongly correlated with alerting, is supported by the findings from a previously published study \[[@b5-medscimonit-24-7785]\]. Therefore, elderly patients may be at particular risk of postoperative impairment of alerting function. In the current study, the alerting, orienting, and executive attention functions were significantly impaired in both groups of patients (the BIS group and the non-BIS group) at postoperative day 1 compared with the pre-operative values. At postoperative day 5,between the study groups.

Conclusions
===========

In elderly patients undergoing radical surgical resection of colon carcinoma, bispectral index (BIS) monitoring during anesthesia, assessed using the Attention Network Test (ANT) to study alerting, orienting, and executive functions, was associated with reduced intravenous propofol anesthetic exposure, early postoperative recovery of alerting and orienting functions by postoperative day 5. In this patient group, the findings from the Confusion Assessment Method (CAM) showed that BIS monitoring during anesthesia reduced postoperative delirium. The findings of this study support the use of BIS monitoring to guide the administration of general anesthesia in elderly patients.

This study was partly supported by our colleagues from the Department of Gastrointestinal Surgery of The First Affiliated Hospital of Wannan Medical College; we thank them for their contributions.

**Source of support:** Departmental sources

![Schematic representation


                       296 Nebraska R eports
                    CLARKE v. FIRST NAT. BANK OF OMAHA
                              Cite as 296 Neb. 632

      The running of the time for filing a notice of appeal shall
      be terminated as to all parties (a) by a motion for a new
      trialAs a result, we determine that our holding in Reutzel has
been superseded by statute and our holding in Dale Electronics,
Inc. again has merit.
   FNB also references Haber in support of its jurisdictional
argument. However, Haber is not informative, insofar as it
is procedurally distinguished. In Haber, the appellant filed
a notice of appeal after the court had overruled one party’s
motion for new trial and partially overruled the other party’s

38
      § 25-1912(2) (Reissue 1995) (emphasis supplied).
39
      Reutzel, supra note 22.
40
      Dale Electronics, Inc., supra note 34.


official tournaments, and several others to conceal their game tactics without being recognized by other players they may meet online: global rankings and leagues are public just as in chess and tennis, while game logs are available and prone to analysis by means of visualization and machine learning just as in standard sport analytics. Accordingly, we are facing a set of players, generating behavioural data, in an unknown one-to-many relationship with avatars (handling *many-to-many* relationships is left to future work). In this context, the [*avatar aliases identification problem*]{} aims at discovering the group of avatars belonging to the same player. Solving this problem is motivated by the growing need of e-sport structures to study the games and strategies of the opponents (match preparation), and the security challenges ofgiven a normalized confusion matrix ${\ensuremath{\tilde{C}^\rho}}$, we would like to find pairs of avatars $a_i,a_j \in U$ such that ${\ensuremath{\tilde{C}^\rho}}_{ij} \simeq {\ensuremath{\tilde{C}^\rho}}_{ji} \simeq {\ensuremath{\tilde{C}^\rho}}_{ii} \simeq {\ensuremath{\tilde{C}^\rho}}_{jj}$ and ${\ensuremath{\tilde{C}^\rho}}_{ij} + {\ensuremath{\tilde{C}^\rho}}_{ji} + {\ensuremath{\tilde{C}^\rho}}_{ii} + {\ensuremath{\tilde{C}^\rho}}_{jj} \simeq 2$. These conditions come from the fact that, if $a_i,a_j$ correspond to the same player, traces in $T_{a_i}$ have the same probability of being classified as $a_i$ or $a_j$ (the same for traces in $T_{a_j}$). Furthermore, for a trace of avatar $a_i$, it is required that the probability of classification is spread between $a_i$ and $a_j$ only, meaning that ${\ensuremath{\tilde{C}^\rho}}_{ij} + {\ensuremath{\tilde{C}^\rho}}_{ii} \simeq 1$ (similarly for $a_j$).

Method
======

Our method firstly extracts fuzzy concepts from the confusion matrix, scores and post-processes them to generate avatar pairs, candidates to be aliases.

**Fuzzy concepts in a confusion matrix.**


even though it is not an avatar cluster since it violates the first condition. The cluster score for this particular case can be calculated as: $cluster\_score(a_i,a_j) = cosine (\langle 1,0 \rangle, \langle 0,1 \rangle) = 0$, meaning that this candidate pair is not an avatar cluster. Notice that for the pair of avatars such that $a_{ii} = 1$ and $a_{jj} = 1$, the cluster score is 1 (cosine between parallel vectors) while the pair is not an avatar cluster. However this pair would have a score $s$ equal to 0 and would be at the bottom of the ranked candidate pairs. A third kind of pair occurs when the traces of $a_i$ and $a_j$ are all incorrectly classified as a third avatar $a_k$. In such a case, theselected 955 professionals games of 171 unique players which cannot contain avatar aliases[^4]. The second collection, which have possible avatar aliases, is built with all replays available on *SpawningTool.com* in July 2014, for a total 10,108 one-versus-one games and 3,805 players. This collection corresponds to a real world situation, and is used for evaluating our avatar alias resolution approach.

**Classifying avatars.** Our method analyses the confusion matrix of a given classifier $\rho$. Good features, as well as a prediction method, should first be chosen. As features, we use the hotkey usage count [@DBLP:conf/chi/YanHC15] during the $\tau$ first seconds of the game: there are 30 of such features ($\{0,...,9\} \times \{assign, remove, select\})$. We also consider the *faction* of the player, the game outcome (*winner* or *loser*) and actions per


even be found at the bottom indicating that they do not belong to the same user. This fact is reflected in the gap between the high growth of precision and low degradation of recall, i.e. avatars with the same name are distributed between the pairs retrieved and those that were not. As we have discussed, avatars with the same URL necessarily belong to the same user. Hence, we would have expected that in the first 10 pairs retrieved we could find an even distribution of surrogates and URLs. Instead, for all classifiers, P@10 is more than 80% surrogates (while the rest is always URLs - P@10 in the medium part of the table). Table \[table.avatars.details.2\] shows a summary of results when looking for just surrogates while varying the balancein the distribution of traces between them. We can clearly observe that the performance of the approach quickly degrades as more imbalanced gets the distribution (the higher the $\beta$ value). Actually, for some classifiers it is not possible to obtain a single good result, even when we have lowered the $\lambda$ threshold to 0.8. As URLs are not necessarily balanced, classifiers tend to predict the label of a trace belonging to an avatar with less traces to one with more traces. Issues related to learning from imbalanced datasets are reviewed in [@He:2009:LID:1591901.1592322] and need to be considered when selecting a proper classifier for our particular application.

Conclusion {#sect:conclusions}
==========

We introduced the problem of avatar aliases identification when there exists no mapping between individuals and their avatars. This is an important problem


unique asset
on their balance sheet. From there, they get the $ to exploit it, create jobs,
etc. It is certainly a booming market and the demand will never stop. I don't
think it's the same game factory-building versus discovery. The question is
more environmental, economical and personal ambitions from my point of view.

------
acgourley
A lot of commentary on idea vs execution misses an important point - while
some ideas have inherent value, people won't believe it until you prove it
anyway!

There are so many "fools gold" mines being proposed and pitched, until you
setup some equipment and bring out real, sparkling gold... statistically no
one will try and compete and certainly no one rational will invest.

------
ThomPete
It takes great execution to come up with a good idea.

= 0.08), more duodenal lesions (P = 0.09) and higher oocyst production (P = 0.02) after inoculation of E. acervulina. Higher lesion scores and faecal oocyst numbers were especially found when suboptimal incubation was combined with heat exposure preceding the infection. In conclusion, SI layer chickens tend to be less able to cope with an infectious challenge post hatch.


The last three posts were mostly about the adjustments of the ocean data done in the Karl 2015 paper. This because the adjustments in ocean data had the biggest impact on the result (that there wasn’t something like a “hiatus”). Kevin Marshall of the excellent blog manicbeancounter.wordpress.com reminded in a comment on previous post that surface datasets had issues as well.

I could agree with that one, I also had written a post in the first year of blogging: Things I took for granted: Global Mean Temperature,, that described how my perception of a global mean temperature changed from believer until skeptic and why I had a hard time to believe that the (surface) datasets were accurate enough to capture an 0.8 °C increase in temperature over 160 years.

Readingignoring high quality data and adjust low quality data.

This indicates that the dataset is ever changing, although the measurements stay the same. This indicates that this data is not of a good quality in the first place, therefor in need of adjustments to correct for the problems with it. This raises some questions like for example: how do we know whether the current estimate is correct? Apparently the estimates in the past were not correct and had to be adjusted. If the estimates are that pliable and so easily (re)adjusted, then how reliable are the results?


Ship Channel), but were found to use nearshore channels more frequently. Satellite-tracked manatees swam faster and moved more directly in all channel types, indicating these channels as migratory and travel corridors. In estuaries and rivers, manatees traveled north and south, consistent with movement among foraging habitats and other essential resources.

The approach used in this study can be applied to a wider range of species among locations to help predict when and how marine megafauna use ship channels and to evaluate risks associated with channel use.

This work was supported by the National Science Foundation, the State of Alabama, and other independent agencies.Yew" ensured that the Yatagarasu never achieved its true goal. Three years after the KG-8 Incident, Deid Mann, an employee at the Cohdopian Embassy, moved to testify against the smuggling ring, just as Cece Yew had done. Around the same time, Byrne Faraday infiltrated the embassy and stole what would later be known as the Yatagarasu's Key, a key that could be converted into a knife, which unlocked a safe belonging to Manny Coachen containing evidence of his involvement in the smuggling ring.

"Calisto" took care of both threats to the smuggling ring by hiring Mack Rell to kill Mann and then claim to be the Yatagarasu. This made Faraday take an interest and he promptly became the prosecutor for the case. "Calisto" then told Rell to accuse Faraday


information theory, the correlations between two different random variables $A$ and $B$, with probability distributions $p_{i}$ and $q_{i}$ corresponding to the obtained values of ${a_{i}}$ and $b_{i}$, can be characterized by mutual information[@Cover1991]: $$I(A:B)=H(A)+H(B)-H(A,B), \label{mutual}$$ In Eq. (\[mutual\]) $H(A)$ ($H(B)$) is the Shannon entropy representing the uncertainty of the outcomes of $A$ ($B$), such that $H(A)=-\Sigma_{i}p_{i}\log_{2}p_{i}$ ($H(B)=-\Sigma_{i}q_{i}\log_{2}q_{i}$). Note that $H(A,B)=-\Sigma_{i,j}p_{ij}\log_{2}p_{ij}$ is the joint entropy where $p_{ij}$ represents the joint probability of the outcomes of $A$ and $B$ being $a_{i}$ and $b_{j}$, respectively, and $p_{i}=\Sigma_{j}p_{ij}$ ($q_{j}=\Sigma_{i}p_{ij}$). According to the Bayes rule, the conditional probability can be written as $p_{i|j}=p_{ij}/q_{j}$. As a result, classical mutual information has the equivalent form $$J(A:B)=H(A)-H(A|B), \label{conditional}$$ where $H(A|B)$ is the conditional entropy of $A$ when $B$ is known, and $H(A|B)=-\Sigma_{i,j}p_{ij}\log_{2}p_{i|j}=H(A,B)-H(B)$.

In the quantum case, thetransfer to the reservoirs at the end of the system’s evolution.

The transference of quantum correlation between systems and reservoirs has also been considered in a multi-qubit systems. Man [*et al.*]{}[@Man2011] studied a simple system of three entangled qubits ($A$, $B$, and $C$) which were coupled to three independent reservoirs ($a$, $b$, and $c$), and investigated the time evolution of discord for any two qubits. The Hamiltonian for this total system can be expressed as the sum of three independent spin-boson models $$H=H_{Aa}+H_{Bb}+H_{Cc}$$ where $H_{Xx}=\omega_{q}\sigma_{X}^{+}\sigma_{X}^{-}+\sum_{j}\omega_{j}x_{j}^{\dag}x_{j}+\sum_{j}(g_{j}\sigma_{X}^{+}x_{j}+
g_{j}^{*}\sigma_{X}^{-}x_{j}^{+})$, $Xx\in\{Aa,Bb,Cc\}$, which is similar to the Hamiltonian of Eq. (\[eq:spinboson\]). The qubits $A$, $B$, and $C$ are initially prepared in the extended W-like state and read as $$\rho_{ABC}(0)=\frac{1-p}{8}\mathbf{1}_{ABC}+p|W(0)\rangle_{ABC}\langle W(0)|,$$ where $|W(0)\rangle_{ABC}=\alpha|001\rangle+\beta|010\rangle+\gamma|100\rangle$ with $|\alpha|^{2}+|\beta|^{2}+|\gamma|^{2}=1$, and $\mathbf{1}_{ABC}$ is the identity matrix. The three reservoirs $a$, $b$,


and $H_{int}=g(\sigma_{+}a+\sigma_{-}a^{\dag})$, where $a$ and $a^{\dag}$ denote the annihilation and creation operators for the cavity field. The Hamiltonian for a train of identical pulses of duration $\tau$ is $H_{p}$, expressed as[@Xu2011_2] $$H_{p}=V\sigma_{z}\sum_{n=0}^{\infty}\theta(t-T-n(T+\tau))\theta((n+1)(T+\tau)-t),$$ where $V$ is the amplitude of the control field and $T$ is the time interval between two consecutive pulses. In the authors’ case, $V$ was set to $\pi/2\tau$, which implies the $\pi$-pulse only. The two atoms were initially prepared to be the Werner-like states $$\rho_{AB}=x|\Phi\rangle\langle\Phi|+\frac{1-x}{4}I,$$ where $|\Phi\rangle=\alpha|0\rangle_{A}|1\rangle_{B}+\beta|1\rangle_{A}|0\rangle_{B}$ with $|\alpha|^{2}+|\beta|^{2}=1$ and $x$ represents the purity of the initial states. The cavity field was prepared in the Fock state or the thermal state. The group determined that both entanglement and quantum discord can be enhanced by the application of bang-bang control, and the increased amount is larger withHorodecki, P. Horodecki, and R. Horodecki, [*Phys. Rev. Lett.*]{} [**89**]{}, 180402 (2002). M. Horodecki, [*et al.*]{}, [*Phys. Rev. A*]{} [**71**]{}, 062307 (2005). S. Luo, [*Phys. Rev. A*]{} [**77**]{}, 022301 (2008). V. Vedral, M. B. Plenio, M. P. Rippin, and P. L. Knight, [*Phys. Rev. Lett.*]{} [**78**]{}, 2275 (1997). K. Modi, T. Paterek, W. Son, V. Vedral, and M. Williamson, [*Phys. Rev. Lett.*]{} [**104**]{}, 080501 (2010). B. Dakić, V. Vedral, and C. Brukner, [*Phys. Rev. Lett.*]{} [**105**]{}, 190502 (2010). S. Luo, and S. Fu, [*Phys. Rev. Lett.*]{} [**105**]{}, 190502 (2010). M.-L. Hu, and H. Fan, [*Ann. Phys.*]{} [**327**]{}, 2343 (2012). J. Maziero, L. C. Céleri, and R. M. Serra, “Symmetry aspects of quantum discord", arXiv:1004.2082 (2011). T. Werlang, S. Souza, F. F. Fanchini, and C. J. Villas Boas [*Phys.


= 3*r + 3*n - 0*n, 0 = -4*r - 3*n - 22. Let p(b) = -b**2 + b - 1. Let y(i) = 4527*i**2 + 32*i - 4530*i**2 - 1 - 9*i - 19*i. Calculate r*p(d) + y(d).
d**2 + 3
Suppose -4*u + 35 = 27. Let q(z) = -5*z + u*z - 1 - z + z + 2. Let r(k) = -7*k + 2. What is 5*q(g) - 2*r(g)?
-g + 1
Let f(a) = 25*a + 276. Let i(x) = -46*x - 462. Let t(z) = 5*f(z) + 3*i(z). Let p(y) = -13 - 7*y - 18*y + 2. Calculate 6*p(l) - 11*t(l).
-7*l
Let t(c) = c**2 - 2*c - 2. Let w(m) = -3*m**2 + 5*m + 5. Let j be ((-106)/742)/(1/(-14)). Calculate j*w(g) + 5*t(g).
-g**2
Let q(f)1231*h**2 + 45*h. Let g(j) = -1008188*j**2 - 36840*j. Determine -3*g(z) - 2456*r(z).
1228*z**2
Let a(t) = 4*t**2 - t + 2. Let n(h) = -1. Suppose -v = -50*v - 0*v + 49. Let u be 4 + 0/(-3) + 2. Suppose -m + u = m. Give m*n(k) + v*a(k).
4*k**2 - k - 1
Let r(i) = -3*i**3 - 3*i**2 - 2. Let n(o) = 2335 + 2335 + 12*o**3 + 13*o**2 - 4662. Let u(d) = -d + 1. Let s be u(3). Calculate s*n(t) - 9*r(t).
3*t**3 + t**2 + 2
Let h(p) = -358*p - 11. Let q(r) = -90*r - 3. Give -2*h(i) + 9*q(i).
-94*i - 5
Let h(i) = -i - 8. Let c(y) = -457*y + 71. Let j(u) = 83*u - 14. Let g(b) =


essential part of the second law of thermodynamics in fundamental physics. According to this law there is function $'S'$ named entropy, which can only grow for isolated systems, achieving a maximum at a state of equilibrium. But this is in contradiction with reversibility of the Newton equation and potentiality of the fundamental forces \[1, 2\]. The great importance of the irreversibility problem for fundamental physics explains its big popularity among the physicists. The history of its solution was very extensive and sometimes, dramatic. Therefore, let us reference only few those works, which precisely enough gives a clear picture of the state in the problem of irreversibility \[1, 3, 8, 17\].

A first attempt to resolve this contradiction has been done by Boltzmann. From the $H$-theorem it follows that many-bodyenergy.

The energy, $T_n^{tr}$, is determined by velocity of the center of mass of system. It is depend on relative velocities of subsystems, which depend on the orderliness of motion of particles. Therefore the energy $T_n^{tr}$ is determine the degree of orderliness of the system.

At absence of external forces, the energies, $T_N^{tr}$, and $E_N^{ins}$, according to the law of preservation of a momentum of all systems, are motion integrals.

Let us assume for simplification that the system is consist from two interacting subsystems, both of them is in equilibrium. The equations for the energy exchange for two subsystems have the forms \[14, 15\]:

$${LV_L\dot{V}_L+{\sum\limits_{j=i+1}^L}\sum\limits_{i=1}^{L-1}\{v_{ij}
[\frac{\dot{v}_{ij}}{L}+\frac{\partial{U}}{\partial{r_{ij}}}]\}=
-\sum\limits_{{j_K}=1}^K}\sum\limits_{{i_L}=1}^{L}v_{i_L}
\frac{\partial{U}}{\partial{r_{{i}_{L}{j}_{K}}}} \label{eqn8}$$

$${KV_K\dot{V}_K+{\sum\limits_{j=i+1}^K}\sum\limits_{i=L+1}^{K-1}\{v_{ij}
[\frac{\dot{v}_{ij}}{K}+\frac{\partial{U}}{\partial{r_{ij}}}]\}=
-\sum\limits_{{j_K}=1}^K}\sum\limits_{{i_L}=1}^{L}v_{j_K}
\frac{\partial{U}}{\partial{r_{{i}_{L}{j}_{K}}}} \label{eqn9}$$

Here we take ${LV_L+KV_K=0}$, ${V_L}$ and ${V_K}$ are the velocities of the center of mass for the subsystems; $L$ and $K$ are the number of elements


alarm, we can set that up, too.

We recommend sump pump replacement in Quincy homes if:

You have an old pedestal-style sump pump

Your sump pump is more than 10 years old

There’s significant rust on the sump pump

Your model isn’t large or strong enough for your home

Sump pump repairs would cost nearly as much as replacement

Quincy Plumbers for Sump Pump Repairs

If your sump pump failed a test or let water spill into your basement, you should get it inspected and repaired immediately. You never know when the next nor’easter or summer shower will strike next.

Efficiency Plumbing & Remodeling will troubleshoot your sump pump to figure out why it isn’t pumping, failing to turn on soon enough, getting backflow, or making strange noises. Often you just need the float road or discharge/* SPDX-License-Identifier: GPL-3.0-or-later
 * Copyright © 2016-2018 The TokTok team.
 * Copyright © 2013 Tox project.
 */

/*
 * Functions for the core networking.
 */
#ifdef HAVE_CONFIG_H
#include "config.h"
#endif

#ifdef __APPLE__
#define _DARWIN_C_SOURCE
#endif

// For Solaris.
#ifdef __sun
#define __EXTENSIONS__ 1
#endif

// For Linux (and some BSDs).
#ifndef _XOPEN_SOURCE
#define _XOPEN_SOURCE 700
#endif

#if defined(_WIN32) && _WIN32_WINNT >= _WIN32_WINNT_WINXP
#undef _WIN32_WINNT
#define _WIN32_WINNT  0x501
#endif

#if !defined(OS_WIN32) && (defined(_WIN32) || defined(__WIN32__) || defined(WIN32))
#define OS_WIN32
#endif

#ifdef OS_WIN32
#ifndef WINVER
// Windows XP
#define WINVER 0x0501
#endif
#endif

#ifdef PLAN9
#include <u.h> // Plan 9 requires this is imported first
// Comment line here to avoid reordering by source code formatters.
#include <libc.h>
#endif

#ifdef OS_WIN32 /* Put win32 includes here */
// The mingw32/64 Windows library warns about including winsock2.h after
// windows.h even though with the above it's a valid thing to do. So, to make
// mingw32 headers happy, we include winsock2.h first.
#include <winsock2.h>
// Comment line here to


 *   some clients might not test return of tox_new(), blindly assuming that
     *   it worked ok (which it did previously without a successful bind)
     */
    uint16_t port_to_try = port_from;
    *portptr = net_htons(port_to_try);
    int tries;

    for (tries = port_from; tries <= port_to; ++tries) {
        int res = bind(temp->sock.socket, (struct sockaddr *)&addr, addrsize);

        if (!res) {
            temp->port = *portptr;

            char ip_str[IP_NTOA_LEN];
                     if (walker->ai_addrlen == sizeof(struct sockaddr_in6)) {
                        struct sockaddr_in6 *addr = (struct sockaddr_in6 *)(void *)walker->ai_addr;
                        get_ip6(&ip6.ip.v6, &addr->sin6_addr);
                        result |= TOX_ADDR_RESOLVE_INET6;
                    }


 } else if (result & TOX_ADDR_RESOLVE_INET) {
            ip_copy(to, &ip4);
        } else {
            result = 0;
        }
    }

    freeaddrinfo(server);
    return result;
}

bool addr_resolve_or_parse_ip(const char *address, IP *to, IP *extra)
{
    if (!addr_resolve(address, to, extra)) {
        if (!addr_parse_ip(address, to)) {
            return false;
        }
    }

    return true;
}

int net_connect(Socket sock, IP_Port ip_port)
{
  sockaddr_in *addr = (struct sockaddr_in *)(void *)cur->ai_addr;
            memcpy(&ip_port->ip.ip.v4, &addr->sin_addr, sizeof(IP4));
        } else if (cur->ai_family == AF_INET6) {
            struct sockaddr_in6 *addr = (struct sockaddr_in6 *)(void *)cur->ai_addr;
            memcpy(&ip_port->ip.ip.v6, &addr->sin6_addr, sizeof(IP6));
        } else {
            continue;
        }

        const Family *const family = make_tox_family(cur->ai_family);
        assert(family != nullptr);


Topical imiquimod therapy for lentigo maligna.
Lentigo maligna (LM) presents a challenge for complete surgical excision. Imiquimod is a topical immune-response modifier that acts on the immune system. We report our experience using imiquimod 5% cream as a surgical alternative for treatment of LM. Consecutive patients between December 2004 and February 2006 with LM were treated with topical imiquimod. Data on patient and lesion characteristics, side effects of therapy, posttreatment biopsy results, and follow-up was collected. Seven patients were treated with imiquimod 5 nights/wk for 12.4 weeks. Complete histologic and clinical resolution was seen in 86% (6 of 7 patients), at 19.1 months follow-up. Side effects included erythema (86%) and crusting (71%), resulting in dose alteration in 71% of patients. Topical imiquimod therapy demonstrates a high response rate for(PDA) device, a handheld PDA device, a network, a wireless network, a Local Area Network (LAN), a Wireless LAN (WLAN), a Metropolitan Area Network (MAN), a Wireless MAN (WMAN), a Wide Area Network (WAN), a Wireless WAN (WWAN), devices and/or networks operating in accordance with existing IEEE 802.11, 802.11a, 802.11b, 802.11e, 802.11g, 802.11h, 802.11i, 802.11n, 802.16, 802.16d, 802.16e standards and/or future versions and/or derivatives and/or Long Term Evolution (LTE) of the above standards, a Personal Area Network (PAN), a Wireless PAN (WPAN), units and/or devices which are part of the above WLAN and/or PAN and/or WPAN networks, one way and/or two-way radio communication systems, cellular radio-telephone communication systems, a cellular telephone, a wireless telephone, a Personal Communication Systems (PCS) device, a PDA device which incorporates a wireless communication


O'Reilly Auto Parts store was set on fire.

In the wake of continued police killings, cover-ups, and a deteriorating economic situation, Saturday's events come as no surprise to those paying attention to Milwaukee. The city was recently named the "Worst city for Black Americans" (http://www.tmj4.com/news/local-news/milwaukee- named-worst-city-for- black-americans). Police killings in the Milwaukee area have made protests a regular occurrence in recent years.

Just this summer, a young Black man named Jay Anderson was shot and killed by police in a Milwaukee suburb. Despite protests, the Milwaukee County District Attorney has refused to release recordings of the incident to the public.

In 2014 Dontre Hamilton, a young Black man, was shot 14 times by a Milwaukee police officer after being harassed for resting in a downtown park. The Milwaukee County District AttorneyQ:

Converting a time to valid format

I am trying to come up with a regex to take the following string: 1:38P and convert it to a valid format for parsing in a date.  I need to

Check that the last character is either A or P, and if it is NOT, do nothing to the string.
If the last letter is an A or P, then strip out that letter from the string, and prepend a Zero (0) to the string.

A:

var d = "1:38P";
var pat = /^(\d+:\d+)(A|P)$/;
var m = pat.exec(d);
if (m) { console.log('We have our winner' + 0 + m[1]}


Last night on the All Out Promotions "All or Nothing in the Brick City Part II" Press Conference on ATG Radio, Michael "Slick" Anderson stopped by to discuss his upcoming fight with Alberto Salas for a regional title from Music Mogul Eric B's "WCB" sanctioning body. "Slick" was very confident about his upcoming fight and stated he is only worried about his outfit.Q:

Marginal revenue of a monopolist

A monopolist faces a demand function $Q=4000(p+7)^{-2}$. If she charges a price of p, her
marginal revenue will be:
(a) $p/2+ 7$
(b) $2p+ 3.50$
(c) $p/2-7/2$
(d) $-2(p+7)^{-3}$
Correct answer is obviously c). Why is that? Why marginal revenue is in terms of p here? How to calclulate this?
edit: please explain what is wrong with that question?

A:

You have $p+7=\sqrt{\frac{4000}{Q}}$. Increasing $Q$ by 1 decreases the price that can be charged (on all sales) by $\Delta p$, where $p-\Delta p+7=\sqrt{\frac{4000}{Q+1}}$. So we have $\Delta p=\sqrt\frac{4000}{Q}-\sqrt{\frac{4000}{Q+1}}=\sqrt{\frac{4000}{Q}}\left(1-\sqrt{\frac{Q}{Q+1}}\right)$ $=(p+7)\left(1-\sqrt{\frac{1}{1+\frac{1}{Q}}}\right)$. We now use the approximation $\frac{1}{\sqrt{1+x}}\approx1-\frac{1}{2}x$ for small $x$. So we get $\Delta p\approx(p+7)\frac{1}{2Q}$.
Hence the loss of revenue from the price fall is $Q\cdot\Delta p=\frac{1}{2}(p+7)$. The extra revenue from the extra sale is $p$. So the net extra revenue is $\frac{1}{2}(p-7)$.


removal under INA § 240A(b) [8

U.S.C. § 1229b(b)]. Following a hearing, the Immigration Judge (IJ) denied his

application on the ground that his New Jersey controlled substances conviction rendered

him ineligible for relief. See 8 U.S.C. § 1229b(b)(1)(C). By order entered February 5,

2010, the BIA affirmed the IJ’s decision. Martinez-Moreno filed a timely petition for

review in this Court.1 The government now moves for summary action.

       Upon review, we agree with the government that the BIA correctly concluded that

Martinez-Moreno is ineligible for cancellation of removal due to his controlled substance

conviction. 8 U.S.C. § 1229b(b)(1)(C) renders an alien ineligible for cancellation of

removal if he has been convicted of an offense under § 1182(a)(2). Section 1182(a)(2), in

turn, states that an alien is inadmissible if he has been                  2
      Because the appeal presents no substantial question, see Third Cir. LAR 27.4 and

I. O. P. 10.6, we grant the motion and will deny Martinez-Moreno’s petition for review.

The motion for a stay of removal is denied.

                                              3


prices down as the whole premise of the service is to save students money, and given that on average books sell for about €40 for a single book, these are very reasonable prices.

Do you believe that there is scope to expand the range of services and items that can be offered through Unibooks?

Perhaps e-books or stationary or something similar. At the moment though we are just focusing on continuing to improve the service to make it as easy as possible to sell on no longer required books.

How many people are involved in operating the website, and do you have any plans to hire more people as the traffic on the website increases?

Currently there are three of us. We were all involved in developing the site and we nowshare the day to day tasks of managing the site between us.

However, with the rate the site is growing… we will be soon looking to hire another person to look after the customer service end of things. We expect to have a new hire start with us by Christmas.


it.

What Jimin hadn't anticipated, is meeting his roommate, Yoongi, or realizing his entire cover will be blown if he can't stop going so crazy over that cinnamon and mint scent he has...

*(This is a story containing serious and dark themes with disturbing elements which become more prevelant as the story progresses.)

Summary

Jim had been dating Sebastian for quite a while now. He and the handsome blonde male seemed like the perfect couple, and everyone else around them agreed. Of course, it didn’t mean Jim didn’t want other omegas or betas, but he had promised Sebastian he would never leave him. And he didn’t, until he met Sebastian’s brother and his omega.

Summary

PLEASE READ THE TAGS!

kinkade is the young (18) alpha king of earth nation kingdom (similar to northern africa/ ancientGoogle recently announced the beta release of Flutter at Mobile World Congress 2018. Flutter is new open-source mobile UI framework that’s used to build native apps for both iOS and Android.

Flutter uses Dart to write applications, so the syntax should look very familiar if you already know Java, JavaScript, C#, or Swift. The code is compiled using the standard Android and iOS toolchains for the specific mobile platform — hence, much better performance and startup times.

Flutter has a lot of benefits for developers:

The project is open-source

Hot reloads for quicker development cycle

Native ARM code runtime

Rich widget set & growing community of plugins backed by Google

Excellent editor integration with Android Studio & Visual Studio Code

Single codebase for iOS and Android with full native performance that does not use JavaScript as


depositing a thin-film on a substrate and then by patterning the deposited film. Such a thin-film process meets the integration of the device by, for example, providing a microscopic width of the formed thin-film pattern with high accuracy. Here, a planarizing process is significantly important as well as the patterning process.
The planarizing process is a process for eliminating or reducing the variation in thickness or the step on the surface of the film deposited on the substrate. As a conventional technique of the planarizing process, there is, for example, an etch-back method. The etch-back method is a widely-used technique in which a resist, a spin-glass (SOG) or the like is applied so as to wholly cover the thin-film pattern formed on the substrate, and then the surface offalse
    });

    Folder.setValueId($stateParams.value_id);
    Folder.setCategoryId(_.get($stateParams, 'category_id', null));

    $scope.computeCollections = function () {
        var unlocked = Customer.can_access_locked_features || Padlock.unlocked_by_qrcode;

        var compute = function (collection) {
            var destination = [];
            angular.forEach(collection, function (folder_item) {
                if (unlocked || !folder_item.is_locked || (folder_item.code === 'padlock')) {
                    if (unlocked && (folder_item.code === 'padlock'))


    $scope.search_list = compute($scope.search_list_data);
    };

    $scope.loadContent = function () {
        Folder.findAll()
            .then(function (data) {
                var values = angular.copy(data);

                $scope.cover = values.cover;

                $ionicNavBarDelegate.title(values.page_title);
                $timeout(function () {
                boundaries, bureaucracy, mandated clinical pathways and professional jurisdictions to achieve optimum patient-centred care. Communities of clinical practice's repertoires are characterised by care and are driven by the moral imperative to care. They do 'whatever it takes', although there is a cost to this form of care. Well-functioning communities of clinical practice use patient's well-being as a guiding light and, by sharing a vision of care through trusting and respectful relationships, avoid fragmentation of care. The Community of Clinical Practice (CoCP) model is particularly useful in accounting for the 'messiness' of community-based care.


I would use the same 12-part scedule, but instead of spending a week on each section, it would be a month. Then I could spend a whole year really exploring the questions Vercillo poses, truly making time for and looking after me.

I haven’t yet read Vercillo’s previous book (Crochet Saved My Life), but have heard at least some of her story through Hook to Heal and through her writing online. I think her work is so important as a contribution to the understanding of mental health and the positive role of creativity in recovery and in everyday living. Vercillo seems like someone who has taken her experience of the most challenging of times, and turned it into a force for good. This book is her gift to allfrom the chapter heading “Relationships and Connecting” to the text box “Yarn for Thought: More Musings on Crafting in Relationships”. The last text box contains 8 bullet points and the final one begins “Do you need to have a serious or difficult conversation … ” and ends “… so that they don’t think that you’re not paying attention!”

This week, week 8 of 12 already!, we remember that no one is an island. We are working on personal growth, healing and change, and this will inevitably affect all of our relationships, but especially the relationships we have with those closest to us. Not forgetting, of course, that one of the most fundamental relationships is that which we have with ourselves.

Spend some time nurturing yourself, your significant other, your family


the Drumtraks. My JX-8P was not connected so I decided to use the old recording and just loop it. Would of course have been more 80’s to play it live! Here’s the result:

Both the brass and bass are stock patches from the JX-8P. All drums are stock Drumtraks. Note how I test the different the different sounds on the percussive channel of the Drumtraks in the end. Claps, tamb, cowbell and cabasa are on the same channel and cannot be played simultaneously. The delay is a classic 80’s trick to get around that limitation.

I just bought a Roland SH-1000 from a guy here in town! It’s Roland’s first synthesizer launched in 1973 – analog and monophonic. But it actually has presets, and a lot of not-so-modern-synth-standard knobs andlittle from each side.

The original EPROM is marked 1.9, just as stated during booting.

The new EPROM from Colin Fraser ready to be inserted.

Before pushing it in place, I made sure that it aligned correctly. Have to be careful with those thin pins.

The new EPROM is pushed all the way in the socket.

Booting pressing H and we see that it’s now 2.30 with some (japanese?) name from 2009.

Booting without H you can see that it now is the JX-10SE. I forgot to take a before photo.

I’m actually not very interested in virtual analogs. With an all digital audio path you could as well use software instruments. One good feature though is that some of the oscillator waveforms are sampled from real classics. The Venom also has classic drum machine


made the deal only available to paid members this weekend at the D23 conference, but it’s now available for everyone through the weekend. To get the deal, you’ll need to sign up to be a member, and then wait for the offer to appear in your account .

If you’re already a D3 member, then it should be there already. If you sign up now, Disney says “it may take up to 36 hours for the offer link to appear in your D23 account page.”

Disney will also email you a link to redeem the offer when it’s available for you.

Worth noting: Many people seem to be taking advantage of this deal right now, so the D23 site is insanely slow. If you’re having trouble getting the site to load,name (7.2) can be hidden by the name of a variable, data member,
  function, or enumerator declared in the same scope. If a class or enumeration name and a variable, data member, function, or enumerator are declared in the same scope (in any order) with the same name, the class or enumeration name is hidden wherever the variable, data member, function, or enumerator name is visible.

So the last A hides the earlier ones. Is that what you were asking?

Re the question: is the program well-formed? Obviously these are just fragments, and no complete program has been presented, but would it be legal if these were the only references to A? My answer is yes. S7.2/6 says:

An enumeration whose underlying type is fixed is an incomplete type from


(21%) were peri-cesarean hemorrhages. Sixteen cesareans delivered lifeless fetuses, where a maternal indication for operative delivery was present in only four. Monitoring of pregnant women was regularly insufficient, including monitoring of women in waiting homes, and the use of uterotonics was often inconsistent. Morbidity review revealed important substandard care factors, including unnecessary cesarean sections. These factors may be modified against affordable cost, which could make an important improvement in maternal outcome.the addition of "Wife Swap US" to its programming lineup and began promoting the show. Id. Compl. ¶¶ 7, 23-26. Plaintiff further avers that it owns the copyright and trade dress rights in each episode of "Wife Swap UK" and "Wife Swap US." Compl. ¶¶ 12, 17.
Defendants, on the other hand, are alleged to produce, develop, and distribute the reality television show "Trading Spouses," which began airing on the Fox network in July of 2004. Compl. ¶¶ 8-9. Plaintiff alleges "that `Trading Spouses' unlawfully copies and incorporates `all of the expressive elements and trade dress of `Wife Swap US' and `Wife Swap UK.'" Id. Compl. ¶ 29.
Based on the foregoing, Plaintiff asserts eight claims against Defendants. The First through Third claims assert copyright infringement, alleging that Defendants infringed


Rule 56, and all parties shall be given reasonable opportunity to present all material made pertinent to such a motion by Rule 56." Fed.R.Civ.P. 12(b).
For all these reasons, "[d]ismissal is warranted only if it appears to a certainty that [plaintiff] would be entitled to no relief *561 under any state of facts that could be proved." NL Indus., Inc. v. Kaplan, 792 F.2d 896, 898 (9th Cir.1986). However, a court need not accept as true unreasonable inferences or conclusory legal allegations. W. Mining Council v. Watt, 643 F.2d 618, 624 (9th Cir.1981), cert. denied, 454 U.S. 1031, 102 S.Ct. 567, 70 L.Ed.2d 474 (1981). Finally, dismissal is proper only in extraordinary cases. United States v. Redwood City, 640 F.2d 963, 966 (9th Cir.1981).
"Dismissal without leave to amend iscase may be dismissed under Rule 12(b)(1). Fed.R.Civ.P. 12(b)(1); 17 U.S.C. § 411(a).
In Plaintiff's Opposition filed on March 4, 2005, Plaintiff concedes that as of the date of the filing of the Complaint only the first episode had a registration effective date prior to the commencement of this action.[1] Opp'n at 5-6.
However, on March 4, 2005, Plaintiff's counsel, Samuel E. Rogoway, submitted a declaration that on March 2, 2005, he was advised by the Copyright Office that the copyright certificates for all nine of the "Wife Swap US" episodes identified in the Complaint had issued. See Rogoway Decl. ¶ 6, Ex. A. As such, all of RDF's registrations are now effective. This issue is now moot. Therefore, the Motion to Dismiss claims One through Three of the Complaint


that "the same elements of an original work may be protected as both copyrightable expression and the trade dress of the work itself." Opp'n at 8-9. While this is true, Plaintiff's argument is disingenuous. RDF posits, "in a principally visual medium, a creator or producer's expressive choices will necessarily manifest visually on the screen; and that visual expression necessarily will form the overall look and appearance of the program  in other words, the trade *564 dress."[3]Id. at 9. If this Court were to accept the proposition that "visual expression necessarily will form the overall look and appearance of the program  in other words, the trade dress," then every incident of visual expression would be subject to copyright and trademark protection and that protection would last inperpetuity. This theory has been rejected on numerous occasions. See, e.g., Dastar Corp. v. Twentieth Century Fox Film Corp., 539 U.S. 23, 123 S.Ct. 2041, 156 L.Ed.2d 18 (2003); Comedy III Prods., Inc. v. New Line Cinema, 200 F.3d 593 (9th Cir.2000).
Plaintiff alleges that its trade dress is defined as the "total image and appearance of `Wife Swap US' as shaped by the selection, compilation, arrangement, sequence, and combination of the expressive elements of the program." Opp'n at 9-10. As aforementioned, trademark and copyright protection may coexist. See 1 J. Thomas McCarthy, McCarthy on Trademarks and Unfair Competition § 6:5 (4th ed.2004). However, in this case, they do not. Plaintiff is merely repackaging its copyright claims in trademark causes of action. In its copyright claim, RDF asserts that


trade dress of its series. Opp'n at 11.
Plaintiff's reliance on Clicks and similar cases, is inapposite. In Clicks the plaintiff, Clicks Billiards, Inc. ("Clicks"), operated numerous billiards establishments and alleged that Sixshooters, a competing billiards establishment, had infringed its trade dress, which included various features of the layout of the establishments and their proximity to one another. Clicks, 251 F.3d at 1256. There, trade dress infringement was proper because the subject matter was the look of the billiards establishment. If Clicks had been precluded from asserting a trade dress infringement action, it would have been left without a remedy. Furthermore, and more importantly, the "composite tapestry of visual effects" referred to by the court in Clicks did not constitute the corpus of the service they provided their customers.Washington Post:

“Enrollment is key, first and foremost,” said Sara R. Collins, a vice president at the Commonwealth Fund, a nonpartisan foundation that funds health-care research. “They have to have this critical mass of people so that, by the law of averages, you’re going to get a mix of healthy and less healthy people.”

A big reason the CBO projections were so far off is that the agency overestimated how many people would lose insurance through their employers, which would force them into the exchanges. But there have been challenges getting the uninsured to sign up, too.

The law requires every American to get health coverage or pay a penalty, but the penalty hasn’t been high enough to persuade many Americans to buy into the health plans. Even those who qualify


help prisoners have positive and meaningful contact with family.  For example, the Jessup Correctional Institute in Maryland started a program that provided books for prisoners to read to their children or grandchildren on visiting days.  Other prison libraries have programs in which prisoners are recorded reading stories, and the tapes and books, along with a coloring book and crayons, are sent to their child.  Some inmates try to read the same materials their children are reading, so they have something to talk about with them.

Prison libraries provide a space for inmates to meet with others with common interests.  Though funding is limited, some prison librarians are diligent in providing programming. Such programs include, book clubs and community service projects.  Many inmates utilize the The prosecution in his case wanted to see Hayes’ reading lists after he was convicted of the murder, kidnapping and sexual assault of members of the Petit family. This issue is contentious because according to normal library policies, patron privacy is a very serious matter, and the question of whether it changes within a prison library was highly debated. Conrad (2014) does not mention that any real rulings and/or concrete decisions have been reached as there are strong arguments both for maintaining prisoners’ privacy, as with any other patron, and there are arguments for that privacy to be made available to ensure that there is no danger to the prisoner, prison population or general public.

Censorship is another major challenge reported by prison libraries. The Federal Bureau of


facility libraries. Westport, Conn: Libraries Unlimited.
Conrad, S. (2014). Collection Development and Circulation Policies in Prison libraries: An Exploratory Survey of Librarians in US Correctional Institutions. The Library Quarterly: Information, Community, Policy 82(4). 407-427.
Costanzo, E. & Montecchi, G. (2011).  Prison libraries in Italy.  Library Trends, 59(3), p. 509–519.
Cramard, O. (2011). The long development of prison libraries in France. Library Trends, 59(3), p. 544–562.
Curry, A., Wolf, K., Boutilier, S., & Chan, H.  (2003). Canadian federal prison libraries: A national survey. Journal of Librarianship and Information Science, 35(3), p. 141–152.
Darby, L. T. (2004).  Libraries in the American penal system.  Rural Libraries, 24(2), p. 7–20.
Gerken, J. L. (2003). Does Lewis v. Casey spell the end to court-ordered improvement of prison law libraries? Law Library Journal, 95(4), p. 491–513.
Greenway, S. A. (2007).with blank D-Hanks solution, CS or its derivatives, and were then fluorescent labeled with DiBAC(4) (3). The change of membrane potential was measured by a flow cytometer (FCM). Alternatively, the treated HaCaT cells were labeled with NBD-C(6)-HPC and the change of membrane fluidity was examined under a Confocal Laser Scanning Microscope (CLSM). It was found that CS, TMCs and MCC could significantly affect the secondary structure of keratin in SC in different ways. Although the amide II absorption peak of keratin moved to a lower wave number following treatment with CS, TMCs, or MCC, the beta-turning structure of keratin was converted to beta-sheeting and random coiling after treatment with TMCs and was converted to beta-sheeting and alpha-helix following treatment with MCC and CS. At the same time, CS


and its derivatives all could increase the water content of SC, decrease HaCaT cells membrane potentials and enhance HaCaT cells membrane fluidity significantly. The effect of TMCs appeared to be independent of their DQ. The results suggest that the mechanisms of transdermal enhancement of CS, TMCs and MCC are closely related to their effects on the secondary structure of keratin and water content in SC, cell membrane potential and fluidity.This post has not been vetted or endorsed by BuzzFeed's editorial staff. BuzzFeed Community is a place where anyone can create a post or quiz. Try making your own!

Top 6 Ways To Not Break Up With Your Significant Other

Tired of your significant other? Want to live the single life but not know how to tell them? Well here are the top 6 ways not to.


FIG. 2, in the touch panel 20, the sensor pads 22 are arranged in a plurality of rows and columns, and the driving device 30 determines the point where the touch is generated based on an output signal from the sensor pads 22. In FIG. 2, the signal wiring 23, which delivers the output signal from each of the sensor pads 22 to the driving device 30, is omitted.
Since the touch generating means forms touch capacitance in a relation with the sensor pad 22, the output signal from the sensor pad 22 where the touch is generated is different from that of the sensor pad where no touch is generated. The touch capacitance may vary depending on the area of the sensor pad 22 with which the touch2*t - 2 for a.
-3
Solve v - 2*f = -5, 7*v + 4*f = 12*v + 7 for v.
1
Solve 4*v - 4 = 2*l, -3*v + 12 = -0*l + 3*l for v.
2
Solve -3*y + 0*y = v + 3, 4*y = -3*v - 9 for v.
-3
Solve i = 5*b + 23, -4*i + 3 + 1 = 2*b for b.
-4
Solve -53 = -o + 4*n - 42, 0 = -3*o + n - 11 for o.
-5
Solve -11 = 3*v + m, -4*m = -3*v - m - 3 for v.
-3
Solve -5*g + 21 = -2*d, -3*g = -8*g + d + 23 for g.
5
Solve 5*h = 5*l + 15, -2*l + 0*h = 5*h + 20 for l.
-5
Solve -y + 13 = -3*b, 0*b + 9 =


LONDON (Reuters) - LexisNexis, a provider of legal, regulatory and business information, said on Tuesday it had withdrawn two products from the Chinese market in March this year after it was asked to remove some content.

The issue of academic freedom in China hit the headlines this week after the leading British academic publisher, Cambridge University Press, said it had complied with a request to block online access to some scholarly articles in China.

It later reversed its position.

“Earlier this year LexisNexis Business Insight Solutions in China was asked to remove some content from its database,” LexisNexis said in a statement. “In March 2017, the company withdrew two products (Nexis and LexisNexis Academic) from the Chinese market.”

LexisNexis is owned by information group Relx.Image analysis algorithms for immunohistochemical assessment of cell death.
Light microscopy allows for the inexpensive and fast detection of neuronal /glial cell demise and estimation of infarct and traumatic lesion volumes; the direct correlates of cell death. Quantitative assessment of brain tissue damage following stroke, traumatic brain injury (TBI ) or neurodegenerative diseases, and recovery after therapeutic intervention has been facilitated by recent developments in computer-assisted image analysis technologies that enable more objective and accurate morphometric quantification of cell injury in whole brain sections. In this chapter, the proposed workflow describes what tasks need to be fulfilled to visualize and gauge cell death characterization by histological stains and immunohistochemical markers.


his Facebook that he was looking for culturally representative models for his Diesel campaign, Mercado said she and her friends joined as a "joke." That joke turned into a once-in-a-lifetime opportunity for Mercado as the casting agency requested more photos and eventually booked her for the campaign.

"You all have no idea how speechless I am right now," Mercado wrote on her blog when she saw her Deisel campaign. "Thank you for giving me a chance of a lifetime and believing in me. This is beyond everything."

Just a few months after those images were released and widely circulated in fashion magazines like Vogue, Mercado landed her second gig. This time it involved sporting threads for Nordstrom's summer catalog.

Image Credit: Nordstrom

"With Nordstrom, they saw me in an interview on theDisease Control, that the CDC had deliberately suppressed findings linking the MMR (Mumps, Measles, Rubella) vaccine to autism.

This made it imperative to distract the public from the genuine scandal and refocus attention on the “dread” measles, whose supposed remedy was the tarnished vaccine. This in spite of these statistics:

Those my age can still remember when measles was regarded as a normal, expected, and relatively benign childhood ailment, as is confirmed by these old TV comedy clips:

There is also evidence that vaccines were responsible for the microcephaly that another recent media circus blamed on bites from Zika-bearing mosquitoes, which was then used to justify airplane-spraying of populated areas with insecticides.

SIDS (SUDDEN INFANT DEATH SYNDROME)

Here is one of many SIDS stories you will read at http://www.thinktwice.com/sids.htm:

Our beautiful daughter was born


/**
 * Copyright (C) 2015 Cambridge Systematics, Inc.
 *
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at
 *
 *         http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
 */
package org.onebusaway.admin.model;

import java.util.List;

import org.onebusaway.admin.model.ui.VehicleStatus;

/**
 * Holds the response object in the format expected by jqgrid on the client side
 * @author abelsare
Frustrated by its inability to process travel agency sales through IATA's billing and settlement plans, V Australia launched its own travel agent payment and settlement system. IATA barred the carrier from using the BSPs until it acquires its own operating certificate.

V Australia had sought to gain access to the system under parent carrier Virgin Blue's certificate. V Australia is slated to launch Sydney-Los Angeles service on Dec. 15. It has been selling tickets via direct channels since March.
The new V Australia Settlement Plan, or VSP, was created in partnership with eNett International and in cooperation with the GDS companies. Melbourne, Australia-based e-Nett is a travel payment specialist founded in 2004. The company is owned by U.K.-based PSP International Plc.

VSP will enable travel agents in Australia and New Zealand


are based on different animal models (rabbit, rat and dog) and various types of injury, none of which accurately mimic the pathological situation seen with a true stricture where there is a full thickness ischaemic spongio-fibrosis. Whilst there have been limited clinical trials, none of these have provided adequate objective long-term follow-up or led to more widespread adoption of the results.

A report in humans of 50 patients using small intestinal submucosa without cell seeding \[[@CR23]\] showed after a mean follow-up of 31.2 months (range 24--36 months) the excellent clinical, radiological, and cosmetic findings in 40 (80%) patients. Re-strictures developed in 1 of 10 bulbar, 5 of 31 bulbopenile, and 4 of 9 penile strictures. These all occurred in the first 6 months post-operatively. A randomised controlled trial comparing an acellular matrixon subjective measures and flow rates at 2 years in 98 patients. There was significant variation in the results between different centres, with two low-volume centres reporting success rates of 0% and 50%, respectively, at 1 year with an overall success rate of 67.3% and a 2-year success rate of approximately 60%. From a careful review of this paper, it is in my view likely if urethrography or urethroscopy had been carried out in all of the cases the success rate is likely to have been lower than this. This is clearly less than the success rates noted in a systematic review of more than 2000 anterior urethroplasty procedures described in the literature. For bulbar urethral strictures, there was no significant difference between the average success rates of the dorsal


2424 for l.
45
Solve -186*z - 2723 = -3095 for z.
2
Solve -424*u + 5107 - 16610 = 5881 for u.
-41
Solve 6*c + 217*c + 59*c = 12*c + 32130 for c.
119
Solve -12279 = -2199*k + 2051*k + 5037 for k.
117
Solve 10050*t - 279*t - 656735 = 124945 for t.
80
Solve 30689 = 1171*h + 28153 + 57987 + 21835 for h.
-66
Solve 4711*p - 159206 = 114032 for p.
58
Solve -163*s + 34729 = 31958 for s.
17
Solve 13 = -9*h - 61*h + 152*h + 915 for h.
-11
Solve 13197 = -1701*m + 1452*m for m.
-53
Solve 2963*b = 39*b + 308*b + 80962 - 7714 for b.
28
Solve 69372 = -2843*n + 4535*n for n.
41
Solve -240131 = 38134*t + 82927 - 17986 for t.
-8
Solve -75*o + 28*o + 2982 = -118*o for o.
-42
Solve 31*g= -77*g + 2*g - 2544 for g.
-24
Solve 752*i = 227*i + 83*i - 1125*i + 141030 for i.
90
Solve 6*t + 3*t + 224 - 447 + 367 = 0 for t.
-16
Solve -23367 = 18184*w + 13001 for w.
-2
Solve 1240 = -12*y + 905 + 767 for y.
36
Solve -2681*g + 595362 = 2620*g + 102369 for g.
93
Solve 0 = 22062*g - 22576*g + 49858 for g.
97
Solve -14844 = 607*n + 17934 for n.
-54
Solve 51*u = -60*u - 85*u + 132*u - 1984 for u.
-31
Solve -411*x + 17556 = 121*x for x.
33
Solve 0 = -305*x + 3529*x + 2837 + 15604 + 4127 for x.
-7
Solve 3120 + 15184 + 21976 = -373*a - 387*a for a.
-53
Solve -90219 = -3986*h + 5023*h for h.
-87
Solve -100*k + 2402 + 2436 =


4938 for k.
-1
Solve 261*x + 110205 = -122*x - 196*x - 132*x for x.
-155
Solve 128*a = -64*a + 245*a - 1537 for a.
29
Solve 82759 - 84544 = -51*d for d.
35
Solve -3423 - 700 = 312*z + 869 for z.
-16
Solve 14*a - 70*a + 250 = -534 for a.
14
Solve -428*x + 12282 + 16992 = 146*x for x.
51
Solve 789*x - 26910 = -6396 for x.
26
Solve -84*u - 620*u - 61948 = 207*u for u.
-68
Solve 60*l + 496*l - 12251 = 23304 - 6087 for l.
53
Solve 19257 + 5028 = -291*i - 738*i + 4734 for i.
-19
Solve 72*q - 1352 = 561 + 886 - 711 for q.
29
Solve 533*u + 339 = -1168*u + 15296 + 24166 for u.
23
Solve 682*f - 5120 = -490*f - 108*f for f.
4
Solve 0 =based on discredited reporting by activist organizations.” The company made efforts to block the probes. And the pressure had an effect: Three months after announcing that his office was joining with New York and Massachusetts, the attorney general for the Virgin Islands withdrew his subpoena for nearly four decades’ worth of Exxon documents. Among the measures Exxon took in response to the investigations was to hire Ted Wells, one of the nation’s most prominent white-collar defense attorneys, whose clients have ranged from I. Lewis “Scooter” Libby — the former adviser to Vice President Dick Cheney — to financial giants such as Citigroup, Bank of America, and JP Morgan.

Ted Wells, center, lead attorney for Exxon, leaves New York Supreme Court after opening arguments in a lawsuit against Exxon on


Ooooooo Ooooooo Ooooooo Ooooooo
We packed our bags and bought some maps
Gathered up a few knick knacks
Throw the guitar in my big back seat
And hit the road for a couple of weeks
Our route's lined out from here to yonder
Our Gypsy hearts are called to wander
We'll sing for our supper and a place to sleep
Swap a few stories with the people we meet
Come take a drive on 66 with me
"Whistle Harmony"
I've planned a few stops along the way
Couple little spots we can stop and play
Take a few pictures make some memories
Count the stars in the desert livin life as we please
Our route's lined out from here to yonder
Our Gypsy hearts are called to wander
We'll sing for our supper and a place to sleep
Swap a few stories with the people weaim studies are proposed to examine whether luminal/lysosomal sialyl O-acetylesterase alters antigen receptor signal strength by acetylating sialic acid containing ligands for CD22, and thereby contributes to a major reduction in marginal zone B cells in mice lacking this enzyme. The regulation of luminal/lysosomal sialyl O-acetylesterase expression and activity during B cell development and B cell activation will be examined. In the second specific aim studies are proposed to examine why the absence of this sialyl-O-acetylesterase results in the loss of recirculating follicular B cells in the bone marrow. The cell intrinsic nature of this defect will be examined and molecular mechanisms involved in retaining mature B cells in the bone marrow will be explored. In this study we will ask how certain immune cells develop and are


and adapt to new hosts more easily (Denison et al. [@CR9]; Lau and Chan [@CR18]).

Viral proteases are essential for pathogenesis and virulence. Like all coronaviruses, MERS-CoV contains two cysteine proteases (main protease and papain-like protease) which processes viral nonstructural polypeptides (Kilianski et al. [@CR16]; Hilgenfeld [@CR14]). MERS-CoV main protease (M^pro^, also called the 3C-like protease, 3CL^pro^) cleaves at eleven sites, while MERS-CoV papain-like protease (PL^pro^) cuts at three sites on the nonstructural polypeptides and releases mature nonstructural proteins (Hilgenfeld [@CR14]). Thus, MERS-CoV proteases make up a suitable target for antiviral therapies.

MERS-CoV open-reading frame 1 (ORF1) encodes two large polyproteins (pp1a and pp1b). MERS-CoV PL^pro^ domain is encoded on the pp1a proteins (residue 1484--1800) (Yang et al. [@CR39]; Hilgenfeld [@CR14]; Kilianski et al. [@CR16]). Like other coronaviruses, MERS-CoV PL^pro^pET28a plasmid under T7 promoter as published before (Lin et al. [@CR22]). The codon was optimized (GenScript, USA) and cloned between NcoI and XhoI sites which was in frame of C-terminal His tag present on the vector. *E. coli* BL21 (DE3) pLysS was used for the expression of recombinant protein. Low-molecular weight protein markers, prepacked Ni-NTA, and Superdex 75 columns were from Amersham Biosciences (United Kingdom). Chicken egg lysozyme was from USB Corporation, USA. Benzonase, ANS, and kanamycin from Sigma. IPTG was purchased from Bio Basic, Canada. All other chemicals used in this study were of reagent grade. Cary 60 spectrometer and Cary Eclipse spectrofluorometer were from Agilent technologies, USA. AKTA purification system was from Amersham Biosciences (United Kingdom) and SDS-PAGE assembly from Bio-Rad (USA). Thermomixer and benchtop


0--50% Buffer B (equilibration buffer containing 500 mM Imidazole) at 1 mL/min flow rate on AKTA purification system. The purity of eluted fractions was analyzed on SDS-PAGE.

The prepacked Superdex 75 equilibrated with 20 mM Tris, pH 8.5, 100 mM NaCl, and 1 mM DTT was calibrated with proteins of known molecular weight. Subsequently, Ni-NTA-purified MERS-CoV PL^pro^ was further purified using Superdex 75 column. The purity of eluted fractions was analyzed on SDS-PAGE. Highly pure fractions were pooled, aliquoted, and stored at −80 °C.

Protein quantification {#Sec5}
----------------------

Before analysis, the frozen aliquots were thawed and centrifuged at 13,000 rpm for 15 min at 4 °C. Protein concentration was determined spectrophotometrically at 280 nm using a molar extinction coefficient of 42,400 M^−1^ cm^−1^.

Fluorescence spectroscopy {#Sec6}
-------------------------

Tryptophan fluorescence spectra (50 µg/mL) of MERS-CoV PL^pro^ were recorded using a Cary Eclipse Fluorescence Spectrophotometer in a 10-mm-path length cuvette.To measure tryptophan fluorescence, MERS-CoV PL^pro^ sample was excited at 295 nm and emission spectra were collected between 305 and 400 nm (5 nm excitation and 5 nm emission bandwidth). Temperature melting studies of MERS-CoV PL^pro^ were performed at 10 °C increments as well as a linear increase of 1 °C/min. MERS-CoV PL^pro^ incubated at different temperatures from 20 to 90 °C in Peltier-controlled Cary eclipse fluorometer. The temperature of the protein samples was monitored using an internal temperature probe. When the desired temperature was reached, the sample was allowed to equilibrate for 2 min before tryptophan fluorescence spectra were measured. The maximum fluorescence intensity (*I* ~max~) and maximum fluorescence wavelength (*λ* ~max~) were plotted with respect to temperature. In a similar experiment, MERS-CoV PL^pro^ was gradually heated from 20 to 80 °C at a rate of


fractions of MERS-CoV PL^pro^

Thermal shift assay {#Sec11}
-------------------

Intrinsic fluorescence spectroscopy is a highly sensitive tool, which provides information about the microenvironment of Trp and Tyr residues within proteins. Tyrosine emission maximum is less sensitive to its local environment compared to tryptophan. Indole ring in the tryptophan residues undergoes two isoenergetic transitions which causes polarity sensitivity, while tyrosine undergoes through a single electronic state (Ghisaidoobe and Chung [@CR11]). During the course of protein unfolding, the polarity of fluorophore microenvironment changes, which in turn leads to changes in the maximum fluorescence intensity (*I* ~max~) as well as maximum fluorescence wavelength (*λ* ~max~). Therefore, intrinsic tryptophan fluorescence emission is sensitive to the tertiary structure and detects subtle protein conformational changes in solution. It has been frequently used for the characterization of protein'swith the side chains of the five Trp residues being *numbered* and colored in *blue* Fig. 3Thermally induced structural changes in MERS-CoV PL^pro^ as monitored by the intrinsic tryptophan fluorescence spectroscopy. **a** To monitor tryptophan fluorescence at different temperatures, MERS-CoV PL^pro^ was slowly heated and allowed to equilibrate for 2 min at the respective temperatures. The sample was excited at 295 nm and the emission spectra were collected from 305 to 400 nm (5 nm excitation and 5 nm emission bandwidth). **b** Effect of temperature on the tryptophan emission intensity showing the decrease of *I* ~max~ with increasing temperature. Major transition occurred between 50 and 60 °C. **c** Effect of temperature on the tryptophan maximum emission wavelength (*λ* ~max~). *Blue-shift* was observed during thermal unfolding of MERS-CoV PL^pro^. Initially, *red-shift* was observed when the temperature


plotted as a function of temperature. The *mid-point* of transition was identified as the thermal melting point (*T* ~m~)

Since MERS-CoV PL^pro^ is a protease, it may undergo autolysis during thermal shift assay. It contains one potential autolysis site (LKGG) as shown in Fig. [2](#Fig2){ref-type="fig"}a. To evaluate the extent of autolysis as well as the extent of irreversible thermal unfolding and aggregation, MERS-CoV PL^pro^ (0.2 mg/mL) was incubated on a thermomixer from 20 to 70 °C with 10 °C intervals. Six samples were gradually heated and equilibrated at the respective temperatures for 3 min. When the desired temperatures were attained, the samples were removed, kept on ice, and centrifuged at 13,000 rpm for 15 min to remove any forming aggregates. Equal volumes of the supernatant were analyzed (Fig. [5](#Fig5){ref-type="fig"}). If MERS-CoV PL^pro^ would undergo autolysis during thetheir relative concentrations during the unfolding process (Malik et al. [@CR24], [@CR25]). MERS-CoV PL^pro^ was gradually heated from 20 to 94 °C at 1 °C/min increments and far-UV CD spectra were recorded from 200 to 250 nm. Far-UV CD spectra at several wavelengths were plotted as a function of temperature (Fig. [6](#Fig6){ref-type="fig"}a). MERS-CoV PL^pro^ underwent a single thermal transition as a function of temperature, suggesting two-state folding. Similar transition was also observed in the thermal shift assay using fluorescence spectroscopy. In an earlier study, secondary structure content was calculated and it was found that β-sheet structure (31%) is dominant in MERS-CoV PL^pro^ (Lin et al. [@CR22]). Similarly, our results showed that MERS-CoV PL^pro^ presented a single negative minimum at \~218 nm suggesting a predominant β-sheet structure as well. When MERS-CoV PL^pro^ was gradually


sanitization recommendations as laid out by our provincial health authorities.

Along with everyone world-wide, we look forward to life becoming “normal” again as soon as possible.

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Lead dentist Dr. Stephen Gaines is an authority on restorative, cosmetic, rehabilitative, and laser dentistry. Having graduated from the University of Toronto, he earned his dental degree from the University of Michigan School of Dentistry (1997). He follows continuing education courses to keep up with dentistry developments. He’s a lecturer, trainer and Fellow and Founding Member of the World Congress of Minimally Invasive Dentistry.

Read What Our Patients are Saying

Jenn L.The staff atit to be less than 10. We expected the
Martian atmosphere to be mostly nitrogen, like our own, but it turned out to be
mostly carbon dioxide. The polar ice caps were not the water ice as we had
expected but mostly dry ice (frozen carbon dioxide). Mariner 9 sent back over
7,000 images of the planet during the next eleven months.

On the night of November 1 1977 Charles Kowal discovered Chiron. This icy
asteroid was the first of a population of objects orbiting in the outer Solar
System.


delegation of the Calcutta Diocese of the Church of North India on September 19 met West Bengal Chief Minister Mamata Banerjee while around 1,000 Christian schools in the state were shut to protest the ransacking and police inaction during the vandalism.

The delegation sought protection of minority-run institutions in the state.one member from each supervisors district. Counties which subsequent to the establishment of the junior college joined the district shall have only two trustees, one of whom shall be the county superintendent of education. However, the board of trustees so constituted, by appropriate resolution, may enlarge its number to six trustees from each county, in which case one shall be the county superintendent of education and there shall be one chosen from each supervisors district. In any case in which there is an equal number of trustees, the board of trustees may appoint another person to membership.
.   .   .   .   .   .
The board of supervisors shall elect the requisite number of discreet persons of good moral character, sufficient


education and experience, and of proven interest in public education, who are qualified electors of the county, as trustees of the junior college; annually thereafter the board of supervisors in like manner shall fill vacancies.[2]
It is the plaintiffs' contention that this statute, as applied to determine the composition of the board of trustees of the Northeast Mississippi Junior College District, violates rights afforded them as citizens of Alcorn County under the Equal Protection Clause of the Fourteenth Amendment to the extent that representation of the board is not apportioned according to the financial contribution, the total population, or the student population of the constituent counties of the district.
Pursuant to the above-quoted statute, six members of the board of trustees of Northeast Junior College are residents of Prentiss County,    var random = new Random();
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            listView1.TileSize = new Size(200, 50);
            listView1.Items[0].ImageIndex = 0;
            listView1.Items[1].ImageIndex = 1;
            listView1.Items[2].ImageIndex = 2;
            listView1.Click += (s, e) =>
            {


      }

        private void CreateMyListView()
        {
            // Create a new ListView control.
            ListView listView2 = new ListView
            {
                Bounds = new Rectangle(new Point(0, 0), new Size(400, 200)),

                // Set the view to show details.
             listView1.Groups[0].TaskLink = "Task";
            listView1.GroupTaskLinkClick += listView1_GroupTaskLinkClick;

            var lvgroup1 = new ListViewGroup
            {
                Header = "TaskGroup",
                TaskLink = "Task2"
            };

            listView1.Groups.Add(lvgroup1);
            listView1.Items.Add(new ListViewItem


a tumor, termed the "mutanome" [@B40]. In 2012, Matsushita et al. validated the feasibility of combining next-generation sequencing (NGS) and predictive algorithms to identify MHC class I-restricted neoepitopes in a mouse sarcoma model [@B41]. Soon the mode of manufacturing personalized neoantigen vaccines was established, which incorporated exome and RNA sequencing of tumor and normal tissues to identify somatic mutations, followed by computational prediction and prioritization of neoepitopes (Figure [1](#F1){ref-type="fig"}) [@B10]. Generally, neoepitopes are predicted according to their HLA binding affinity [@B42]. Other factors accounting for immunogenicity are also considered in neoantigen prediction and prioritization, including proteasome cleavage preference [@B43], gene expression and peptide abundance [@B44], and structural and physicochemical features of peptide-MHC complexes [@B45]. Neoantigen vaccines derived from this strategy differ from the traditional version in that theynon-coding expressed regions [@B84] and post-translational modifications [@B85]. However, most predictors only identify neoantigens from SNVs, leaving many highly immunogenic neoepitopes undiscovered [@B69]. Secondly, MHC-II alleles are inadequately supported in current prediction tools due to the variable length and binding promiscuity of MHC-II ligands and lack of binding data for model training [@B86]. However, it has been recently appreciated that neoantigen-specific responses are mediated predominantly by CD4^+^ T cells, highlighting the essential role of accurate MHC-II predictions [@B12]-[@B14]. In addition, a majority of predictors predict candidate neoepitopes according to their binding affinity of MHC molecules [@B69], without the consideration of other factors contributing to the immunogenicity such as proteasomal cleavage and peptide transportation [@B43], stability and T-cell receptor (TCR) recognition of the peptide-MHC complexes [@B87], and structural and


simultaneously to DCs and promote their internalization [@B101]. Intracellular delivery is particularly important for long peptide-based vaccines as they must undergo endocytosis [@B3]. Moreover, some pattern recognition receptors (PRRs) are expressed inside the cell, such as TLR3, TLR7, TLR8, TLR9 and STING [@B102]. Delivering vaccines in the form of NPs can therefore improve immune activation and achieve optimal results.

Kuai et al. designed a synthetic high-density lipoprotein (sHDL) nanodisc, of which the surface was decorated with neoantigen long peptides and the TLR9 agonist CpG motif. This nanodisc generated 47-fold greater frequencies of neoantigen-specific CTLs than soluble vaccines with CpG as an adjuvant. Moreover, established MC-38 and B16F10 tumors were eliminated when combined with anti-PD-1 and anti-CTLA-4 therapies [@B103]. Recently, Li et al. reported a simple adsorption strategy using polyethyleneimine1991, considerable efforts have been put into developing peptide-based cancer vaccines, most of which focused on short peptides (8-10 mer) exactly representing the tumor-specific CTL epitopes. However, the clinical translation has met with limited success, and in some cases, peptide vaccination could even accelerate tumor growth. Further exploration revealed that short peptides can lead to immune tolerance, and long peptides (15-31 mer) may act as a more effective platform for therapeutic cancer vaccines. Recent advances in high-throughput sequencing technologies have facilitated the development of personalized vaccines targeting neoantigens derived from nonsynonymous mutations in tumor cells, where long peptides are extensively used. In 2017, the first clinical trial of long peptide-based neoantigen vaccines reported encouraging outcomes in melanoma patients. Subsequent clinical trials have indicated the feasibility in immunologically cold


This guy is a Master Flubber. During his recent
trip to Prague, Bush referred to himself as a ŇdissidentÓ. He was suggesting
that he,, like President Mabarak in Egypt, were dissidents in their fight to
end tyranny. I guess I for once canŐt argue with Bush, he does appear to be a
dissident. I would use the word degenerate, but still, he is a person who does
not follow established protocol or policy. He pretty much makes those things up
as he goes. As far as fighting tyranny, I see Bush more as the master of it
rather than the conqueror of it.If itŐs cruel and arbitrary power you want, he seems to be your man. He
also recently contradicted himself and is now saying Iraq is a lot like
Vietnam. He claims there will be massPartner

Dr. Michael Ritter

Dr. Michael Ritter grew up in Liechtenstein and studied law at the University of Berne, where he gained his doctorate in 1992. He began his professional career in 1984 as a member of the legal staff in the government of the Principality of Liechtenstein. In 1990, the expert in international law was appointed to the Liechtenstein EEA negotiating delegation.

Three years later, Dr. Michael Ritter became a member of the government and served as Economics and Social Minister from 1993 until 2001. In the second period of office of his eight-year period in government, he served as Deputy Prime Minister. He was a member of the board of directors in one of the largest Liechtenstein banks and is currently a member of the board of directors in


  204Q   202Q   200Q

A:

#!/usr/bin/env perl

use strict;
use warnings;

my %station;
while(my $line = <>) {
    my ($id, undef, @day_data) = split(' ', $line);
    push @{$station{$id}}, @day_data;
}

foreach my $sid (sort keys %station) {
    print $sid, ' ', join(' ', @{ $station{$sid} }), "\n";
}

And then
./script.pl your_wheather_file

gives the following output:
AQW00061705 824C 824C 824C 826C 826C 826C 829C 829C 829C 826C 826C 826C 821C 821C 821C 813C 813C 813C 806C 805C 805C 801C 801C 801C 807C 807C 808C 812C 812C 812C 816C 816C 817C 823C 823C 823C
CAW00064757 204Q 202Q 200Q

    } else {
             MainVideoControllerWindow!.showWindow(sender)
         }

     }

     @IBAction func btnPlayVideo(sender: AnyObject) {

         //CANNOT ACCESS THE METHOD HERE
         MainVideoController.playVideo()

     }

 }

FINAL UPDATE: This is the final working block of code that allowed me access to the new Window's functions from any function within the current window. I changed the type of the MainVideoController var declaration to match my custom class and added the conditional "as?" when capturing the contentViewController into the variable. Thank you @bluedome for your help!