in the blue region of the spectrum, is regarded as the primary risk factor for retinal function.^[@i2164-2591-6-4-1-b17]^

In experimental animals, exposure to bright light for a short period of time (up to 24 hours)^[@i2164-2591-6-4-1-b18]^ or daily exposure to high levels of light in a 12/12-hour light/dark cyclic regime^[@i2164-2591-6-4-1-b19]^ can cause major reduction in visual function due to photoreceptor degeneration. Light-induced damage is a multifactorial pathology, depending upon the parameters of exposure to light (irradiance, wavelength, and duration), time of the day at which light exposure occurs, age, history of lighting conditions prior to exposure, rhodopsin content, and photoreceptor status with regard to the balance between generation of reactive oxygen species and antioxidants.^[@i2164-2591-6-4-1-b18][@i2164-2591-6-4-1-b19][@i2164-2591-6-4-1-b20]--[@i2164-2591-6-4-1-b21]^

Since light has been discovered as a potential harmful factor to the retina, several studies have tested potentiallinks between light exposure and retinal diseases. Retinitis pigmentosa is an inherited disease causing photoreceptor degeneration, leading eventually to blindness. It has been hypothesized that exposure to light might speed up the rate of photoreceptor degeneration.^[@i2164-2591-6-4-1-b22]^ However, a 5-year experimental trial in two patients did not support this hypothesis.^[@i2164-2591-6-4-1-b23]^ In glaucoma, researchers suggested that blue light might be a risk factor through the generation of reactive oxygen intermediates following light absorption by cytochrome c oxidase in mitochondria occupying the axons of retinal ganglion cells.^[@i2164-2591-6-4-1-b24]^ Age-related macular degeneration is a macular disease leading to central scotoma and reduced visual acuity. It is a multifactorial disease, with aging being the major factor, but exposure to light also has been suggested as a contributing factor.^[@i2164-2591-6-4-1-b25],[@i2164-2591-6-4-1-b26]^

As discussed above, DR is believed to


exceeded 300 mg/dL. Control rats had blood glucose level around 80 mg/dL. Blood glucose was monitored once a week in all the rats throughout the entire period of follow-up.

Cataract Assessment {#s2c}
-------------------

A trained ophthalmologist, unaware of our working hypothesis and the lighting conditions in which rats were maintained, was responsible for assessment of cataract formation. For cataract assessment, the eye was illuminated with white light, and the magnitude of opaqueness, its density, and location were evaluated. Quantitative cataract assessment ranged from 0 (no cataract) to 5 (advanced mature cataract) according to a previous report.^[@i2164-2591-6-4-1-b32]^

Immunocytochemistry {#s2d}
-------------------

Glial fibrillary acidic protein (GFAP) is normally expressed in astrocytes that are located in the retina--vitreous border around blood vessels, but not in retinal Müller cells. However, following retinal stress of any kind, Müller cellswere kept in compartments 1, 2, and 3. In all retinas, GFAP immunoreactivity is seen in astrocytes, located at the retinal surface, just above the ganglion cell layer that normally expresses GFAP. Expression of GFAP in Müller cells is seen in the three retinas from the diabetic rats ([Fig. 7](#i2164-2591-6-4-1-f07){ref-type="fig"}, right column), appearing as red radial structures, indicating retinal gliosis, probably secondary to retinal damage. The degree of GFAP expression in Müller cells varies between the different retinas, probably signaling different degrees of retinal damage. The most apparent GFAP expression in Müller cells is seen in the retina of the diabetic rat that was kept in unattenuated white light ([Fig. 7B](#i2164-2591-6-4-1-f07){ref-type="fig"}) and in the one raised in the compartment where the light phase consisted of attenuated yellow light


Cuban military activities in Africa and the Middle East underscored the nature of the Havana-Moscow relationship.

The study rejected the assumption that Castro's dispatch of thousands of combat troops to aid the Marxist forces in Angola in 1975 was "a radical and dangerous departure in Cuban foreign policy . . . a calling-in of Cuban debts that led Cuban troops to fight as Moscow's all-purpose mercenaries in a war by proxy."

Instead, the sutdy said that "Though Angola was unique in some respects, in others it matches a pattern of Cuban military diplomacy established over the past decade and a half." In terms of Africa, that Cuban policy goes back at least to the 1961 Ghana mission.

A year or two later, a boatload of Cuban tanks -- obtained from Russiathe 1970s and, in the upcoming years, possibly back toward Latin America, where increasing instability within Central America and the Caribbean could present Castro with new targets of opportunity for military assistance activities.

In most cases there has been a natural community of interest between these Cuban activities and Soviet policy. By cooperating militarily with the Soviets, Castro unquestionably has been able to make partial repayment to Moscow for the massive financial and economic assistance that enables him to maintain Cuba as an independent communist bastion 90 miles from the shores of the United States. Soviet subsidies often pay for troop and weapons transportation and Soviet equipment is provided Cuban forces overseas.

Although Castro regards the Soviet Union as Cuba's natural ally, he has always been assertive of Cuba's right


Representative sampling has to be performed over several periods of groundwater flow fluctuation. For the determination of mass fluxes at heterogeneous sites, however, local fluxes, which may vary considerably along a control plane, have to be accounted for. Here, dosimeter sampling in combination with time integrated local water flux measurements can improve mass flux estimates under dynamic flow conditions.the new owner, who adapted the dilapidated historical building into a high standard hotel, which was opened to the public in 2011 under the name Art Hotel Kastieľ.

References

https://www.hotelkastiel.sk/en/history

Category:Buildings and structures in Bratislava Region


R again.

Here's another couple of possible values plugged into the equation:

This generated this tone:

This tone, which has random perturbations on a 2000 Hz tone, has a substantially fuzzier sound, less pure than the above. You can see why this might be the case by comparing the above equation with the values I used to generate the first tone--both of the coefficients in this newer equation are closer to zero. This means that less of what you're hearing is a periodic function that makes a distinct tone, and you're hearing more of the randomness--i.e. white noise like you'd hear on a TV when you're between channels.

It turns out that , the second parameter, must be between -1 and 0 to be able to generate these tones--if is less thanbe called twice. When the first call resolves, the information can be cached and returned immediately to requestors. With batching, both requestors will be queued up to receive the results of the original call — so when the first call resolves, every queued call gets their results all at once. The net result is, every batched function consumer will piggyback off of the initial requestor and receive their results in less time than they would otherwise. This abstraction also dramatically reduces the load on downstream services.

Data Loaders

Loaders are instances of the DataLoader. DataLoader is a “generic utility to be used as part of your application’s data fetching layer to provide a simplified and consistent API over various remote data sources such as databases or web services via batching


into method parameters to call service methods. A port can be any event trigger; a Kafka consumer reading a message, a queue consumer consuming an event, an HTTP request, a GraphQL resolver — anything that needs to access the domain — will come into your application through a port. A controller method is a handler meant for parsing that request in whatever form it takes and adapting it into something consumable by the service layer. The controller is also responsible for taking the results from the service call, adapting it, and sending it back to the client (where applicable, such as an HTTP request). A controller is just a central place for entry points into the application architecture.

These are the main components that make up our GraphQL API.held with NYU-Polytechnic University in New York City. Some of the "dumb ideas" were myths held by nonsecurity professionals, and others were attitudes still circulating within the security community, Pfleeger said.

In 2005, Marcus Ranum, a chief of security for Tenable Security, published six "dumbest ideas in computer security," including the idea that hacking is cool and just patching flaws found in software products will make it more secure. While many of Ranum's points were valid, Pfleeger developed his own list of security mistakes that are made every day in organizations around the world. The security mistakes are generally the result of ignorance and limited time available to address issues, he said.

"There are a lot of dumb ideas," Pfleeger said.

Further reading

The first one was the idea that organizations can


were classified as non-AD patients. 3D-SSP was used to quantify the regional cerebral blood flow (rCBF) acquired from SPECT imaging. Compared with the transaxial section presentation alone, 3D-SSP presentation improved the area under the receiver operating curve (p<0.05) as well as intra-observer (k=0.73 vs 0.88) and inter-observer (k=0.50 vs 0.84) reproducibility. Upon normalisation of regional to thalamic activity, multiple regression analysis revealed a strong correlation between the MMS and rCBF in the right parietal cortex (p=0.002). Addition of 3D-SSP to the transaxial section display of ECD-SPECT studies improves the reproducibility and the diagnostic performance in respect of AD in patients with cognitive impairment and provides a valid tool for assessment of the severity of cortical perfusion abnormalities in such patients.Forum rules
Welcome to The Scottish Boinc Team boards. See forum rules in pinned post. If you can't be bothered then try not to be too naughty as I have a delete button to press and a ban hammer to swing.

Are you guys still working toward improving your position? I haven't seen a position update in a while. If so, I'm about done with one of my other goals and will be upgrading a WCG badge for the foreseeable future. Since you guys have come to our rescue so many times, I'll be glad to throw in my lot with TSBT for a bit.

Did anyone else notice that after the WCG server maintenance yesterday that all their machines became untrusted? Mine were 100% trusted with only 1/2 page of


pendings on SCC, now that has increased to 61 pages. At this point I'm getting quorum of one, but during the re-trusting I got 100s of quorum of 2 wus.

Edit: Appears the validators are down according to their forum. Looks like a forced bunker that should advance TSBT another spot when it clears.

No obvious problems for me either, mixture of OET and Open Zika.
And, yes Sphynx, as scole says this is still a team priority although it's an ultra-marathon and the sheer tedium of the task can sometimes lead to some collective loss of focus.
But as of today we are up to 130th now!.
We have been helped considerably by your contribution over the last few days, plus of course scole's return to the fold, not to mention mymost of the year to play for, out next year team statement could and probabily will be all projects in the top 100 ....

Nope. Sorry - didn't happen!
Not to worry. It's a case of slow but steady, & we are getting there.
We are 77th by RAC which, if sustained, makes top 100 by TC inevitable, if not necessarily imminent. The game is indeed very much afoot although it's a bloody long one.
Two more places by the end of April seems to be at least possible.
The important thing is that the stalwarts remain stalwart. And I intend to be the stalwarts' stalwart.
Of course any visiting Ubercrunchers are always welcome to lend a few dozen spare cores any time they can!

Yup we are now 128th.
But turbulent times lie ahead.
Fairleigh Dickinson


to this, saying: As you may have noticed , a newsplash up popped up on the PBE. commented on this, sharing that it's based on the new VFX for his plannedrework which didn't make it into this PBE cycle.As for a time frame on these changes, he noted When asked about these new particles / vfx onother skins, he commented Following the Galio changes in 3.11 noted he should have some more ready for PBE testing soon!For those seeking more information on thesechanges, he commented Responding to a thread on the power level of Void Staff, commented that the balance team agrees that Last Whisper and Void Staff are quite powerful and likely need to be brought down a bit.He continued , elaborating on the problem:When suggested thatpackage http

import (
	"bytes"
	"encoding/json"
	"fmt"
	"io/ioutil"
	"net"
	"net/http"
	"net/url"
	"os"
	"time"
)

// HTTPClient is a reusable HTTP Client.
type DefaultHTTPClient struct {
	HTTPClientCommon
	client *http.Client
}

// NewHTTPClient creates a new HTTPClient.
func NewDefaultHTTPClient(host string, debug int, dialTimeout time.Duration, readTimeout time.Duration, writeTimeout time.Duration) *DefaultHTTPClient {
	return &DefaultHTTPClient{
		client: &http.Client{
			Timeout: readTimeout, // TODO sets all timeouts
			Transport: &http.Transport{
				Dial: (&net.Dialer{
					Timeout: dialTimeout,
				}).Dial,
				MaxIdleConns: 0, // unlimited
				MaxIdleConnsPerHost: 100, // 0 would fallback to DefaultMaxIdleConnsPerHost ie. 2
				MaxConnsPerHost: 0, // unlimited
				IdleConnTimeout: idleConnectionTimeout,
			},
		},
		HTTPClientCommon: HTTPClientCommon{
			Host:       []byte(host),
			HostString: host,
			debug:      debug,
		},
	}
}

// Do performs the action specified by the given Query. It uses fasthttp, and
// tries to minimize heap allocations.
func (w *DefaultHTTPClient) Do(q *Query, opts *HTTPClientDoOptions) (lag float64, err error) {
	// populate uri from the reusable byte slice:
	uri := make([]byte, 0, 100)
	uri = append(uri, w.Host...)
	uri = append(uri, q.Path...)

	// populate a request with data from the Query:
	req, err :=


Western countries have failed to agree on a common approach to the problem and the abduction of European citizens in particular has provided a lucrative cash flow for groups such as al-Qaeda.

While many European countries deny that they pay ransoms, there have been reports that suggest governments frequently use networks of proxies to pay for the release of their citizens.

The U.S. also opposes paying ransoms for hostages. But in 2015 the Obama administration changed its policy of seeking criminal charges against families who pay ransoms to secure the release of their loved ones. Government agencies were also allowed to assist families in those negotiations.

Fred Burton, VP of Intelligence at Stratfor and Gar Pardy, former director general of consular services for Canada, on how governments deal with hostage crises,considerably, and in most cases these differences caused by significant changes in lighting conditions is what makes the task of facial recognition extremely difficult in some cases. The same statement is true for pose variation. These two problematic variables (pose and illumination) significantly cause the degradation of the 2D facial texture mapping of the human face and the overall reduction in the accuracy of the system.


baseline, vs. 35 at follow-up. Three RBD changed to non-RBD at follow-up, while 10 non-RBD patients developed RBD at follow-up (annual incidence of 12.5%). RBD and non-RBD patients did not differ significantly at baseline or follow-up. The presence of RBD at baseline was significantly related to an increase in UPDRS total and bradykinesia scores over time. RBD symptoms can vary over time and have a tendency to increase during the early stages of disease. The presence of RBD symptoms could be a risk factor for motor function deterioration and particularly for bradykinesia worsening.chemical and/or physical methods.

The second paper,*"Green and rapid synthesis of anticancerous silver nanoparticles by Saccharomyces boulardii and insight into mechanism of nanoparticle synthesis,"* by A. Kaler et al. describes an ecofriendly method for the synthesis of silver nanoparticles (AgNPs) by cell free extract (CFE) of*Saccharomyces boulardii*. In addition to the optimization of relevant synthesis parameters as culture age, cell mass concentration, temperature, and reaction time, the paper presents particles characterization by UV-Visible spectroscopy, EDX (energy dispersive X-Rays) analysis, transmission electron microscopy, and zeta potential, as well as the elucidation of proteins/peptides role in nanoparticles formation and stability and their anticancer activity. The method therein described a method that does not require tedious downstream processing and it may be scaled up to develop a viable technology for the Ag-nanoparticle


curve analysis, it was found that reaction followed the ping-pong bi-bi mechanism with dead end inhibition of alcohol. Beside the previous papers herein described, the preparation of chiral secondary alcohols using lipase catalyzed kinetic resolution is mild and clean as compared to chemical process.

In the seventh paper entitled*"Demonstration of redox potential of Metschnikowia koreensis for stereoinversion of secondary alcohols/1,2-diols,"* by V. S. Meena et al. reports the*Metschnikowia koreensis*-catalyzed one-pot deracemization of secondary alcohols/1,2-diols and their derivatives with*in vivo* cofactor regeneration. This ecofriendly method afforded the product in high yield (88%) and excellent optical purity (\>98% ee), minimizing the requirement of multistep reaction and expensive cofactor.

*Bernardo Dias Ribeiro* *Isabel Marrucho* *Luciana Gonçalves* *Maria Alice Z. Coelho*
with HeartMate 3 (MOMENTUM 3) trial demonstrated the absence of pump thrombosis and a trend toward the reduction of non-disabling stroke rate in HeartMate 3 recipients \[[@CR15]\]. The HeartMate 3 is currently approved in the EU (CE mark in 2015) and FDA approved as BTT and as bridge to recovery in the USA (August 2017) \[[@CR16]\].

Axial vs. Centrifugal CF-LVADs {#Sec3}
==============================

Currently, FDA-approved CF-LVADs are the HeartMate II (Abbot Inc., Abbott Park, IL, USA), as bridge to transplant (BTT) and destination therapy (DT), and the HVAD (Medtronic, Inc., Minneapolis, MN, USA) for BTT indication only. The primary difference between the two devices is in the impeller design as it relates to the angle between the impeller outflow and its axis of rotation \[[@CR17]\]. HeartMate II is an axial-flow CF-LVAD, with


pump thrombosis \[[@CR19], [@CR20]\]. Suggested BP targets are much lower than what has been shown to convey risk for cerebrovascular events in the general population, reflecting the peculiar hemodynamic and pathophysiologic consequences of CF-LVAD's design. Current International Society of Heart and Lung Transplantation guidelines \[[@CR21]\] recommend to maintain MAP below 80 mmHg and to use HF drugs for BP management (Level of Evidence C).

Several mechanisms may account for the association between hypertension and adverse events in CF-LVADs \[[@CR22]\]. Elevated BP reduces LVAD flow by an increase in afterload, thus promoting stasis in the pump and, eventually, thrombosis. The thrombosis itself can result in systemic thromboembolism and stroke. In the context of chronic exposure to low pulsatility and therefore reduced endothelial function due to lack of optimal cyclical stress, evenUnder these conditions, the aortic valve tends to remain closed and blood flow in the aorta and peripheral circulation becomes less pulsatile, since the systolic contribution of the unloaded LV is significantly reduced (Fig. [1](#Fig1){ref-type="fig"}c). The opposite is observed at lower pump speeds (Fig. [1](#Fig1){ref-type="fig"}b). The altered physiology that is associated with a change in pump speed is confirmed within the same patient when the failing heart is supported by a Jarvik 2000 device. The Jarvik 2000 is an axial CF-LVAD, which is currently undergoing a prospective, dual-armed, non-blinded (open-label), randomized clinical trial for DT indication. Every minute, it operates at a high speed for most of the time, but reduces its contribution to blood flow for few seconds to increase LV loading and promote aortic valve opening


At a Christie's auction in October 1998, a battered medieval manuscript sold for two million dollars to an anonymous bidder, who then turned it over to the Walters Art Museum in Baltimore for further study. The manuscript was a palimpsest—a written parchment scraped clean and reused by a 13th-century monk. But as classics professor Reviel Netz and curator William Noel found through high-tech scanning and imaging, a trace of the original text remained embedded in the pages, and revealed the words of Archimedes.

"Like a multilayered detective story, Noel's account of Archimedes' precarious chain of transmission from original papyrus to 20th-century America has clues, blind alleys, brushes with oblivion, and compulsive readability.... Noel cogently describes the technical conservation and imaging difficulties the codex presented.... Netz lucidly argues that ArchimedesConjugation of recombinant reverse transcriptase of HIV-1 to beta-D-galactosidase from Escherichia coli for ultrasensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) of anti-HIV-1 IgG.
Recombinant reverse transcriptase (RT) of HIV-1 was conjugated to beta-D-galactosidase from Escherichia coli in three different ways. Maleimide groups were introduced into beta-D-galactosidase molecules using N,N'-o-phenylenedimaleimide in the absence (method I) or presence (method II) of N-ethylmaleimide or into beta-D-galactosidase molecules, which had been treated with excess of 4,4'-dithiodipyridine to block thiol groups, using N-succinimidyl-6-maleimidohexanoate (method III). Subsequently, the maleimide groups were reacted with thiol groups introduced into recombinant RT molecules using N-succinimidyl-S-acetylmercaptoacetate. The conjugates were tested by a sensitive enzyme immunoassay (immune complex transfer enzyme immunoassay). The immune complex consisting of 2,4-dinitrophenyl-bovine serum albumin-recombinant RT conjugate, anti-HIV-1 IgG and recombinant RT-beta-D-galactosidase conjugate was captured


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            shows went into getting a tour bus, so we never saw a penny," Elliott says.

Eventually, things turned around and they had a hit with "Pyromania." Released in January of 1983, it went platinum just three months later. By October of 1984, the album had sold over six million copies.


Q:

Python how to extract variables from expression

Sorry i am new to python. I am trying to extract variables from expression like:
ABC=DEF=5
C=DF/10

i want to extract ABC,DEF,C,DF etc.

A:

This works for the example you have given, it will of course fail for more complex code.
>>> import re
>>> text = '''ABC=DEF=5
C=DF/10'''
>>> re.findall(r'[a-zA-Z_]\w*', text)
['ABC', 'DEF', 'C', 'DF']

Contact Peach Ridge Farms

Peach Ridge Farms has being growing quality produce for some 20 years. We love having visitors at the farm. We are passionate about passing on our knowledge of the land and produce to anyone who is interested.


insulation values to non-western clothing like saris, hijabs, and abayas.

A better understanding of how non-western clothing keeps people warm or cool could translate to energy savings: If a loose-fitting Indian outfit is cooler than a western men’s suit, buildings don’t need to be cooled to the same (very cold) western standard.

The first step was actually collecting all the clothes to study, so Havenith’s U.K. lab along with collaborators in Sweden and Hong Kong hit up all their contacts. The Swedish group found a shop in Sweden where they could order African clothing. A nearby city in the U.K. had a big Indian and Pakistani community, where the lab could shop for clothes from the subcontinent. And the Indonesian outfits they got get custom made in Indonesia; the westerndeveloping world, long-neglected in thermal research, is finally gaining attention.

Thermal comfort researchers in India and China have started to integrate the new insulation values into their research. A man in a suit is no longer the default. And freezing offices will, hopefully, no longer be the default. For the Earth’s sake and ours.

We want to hear what you think about this article. Submit a letter to the editor or write to letters@theatlantic.com.


that a petitioner may have will

be aired fully and fairly in one proceeding and decided upon their merits. See Martucci

v. State, 872 S.W.2d 947, 949 (Tenn. Crim. App. 1993) (noting that “[t]he concept

behind post-conviction petitions. . . is that all claims of constitutional rights deprivations

in the conviction or sentencing process be addressed in one petition.”). The Post-

Conviction Act provides counsel within this context. That is, the provision of counsel is

meant to assist in ensuring that all available grounds for relief are fully aired at one time

and not to obstruct such an airing.

              On the other hand, when a petitioner seeks and obtains the aid of counsel

through court appointment, the petitioner needs to understand that thethirteen days after the third

attorney was allowed to withdraw. The record indicates that little, if anything, had been

done by counsel on the petitioner’s behalf. Needless to say, the imprisoned petitioner

had little capability in such short time to prepare for the hearing. In this respect, I do not

believe that the petitioner has had a legitimate opportunity for a full and fair hearing on

his post-conviction claims.

                                              5
              In consideration of the foregoing,


these examples the child is learning that we use different types of language in different situations. In at least three of these four examples, the storyteller or writer is emphasizing that language variation is normal and healthy, that it's natural to vary the language we use to suit the region, the occasion or company, and the formality of situations we find ourselves in.

However, these obvious realities are not understood or accepted by enough of the American public. One of the unfortunate ways that educational and societal influences "reimagined normal" in the past few hundred years involved imposing unrealistic, inaccurate, and elitist views of language on those who aspired to be educated and successful in mainstream society. Far too many American students and adults still have contradictory, faulty impressionschild figuring out for herself how to adjust to complex social and linguistic realities, Dana's adjustment might have been easier if the adults explained dialect diversity to her more fully, as one West Virginia teacher does for Marty, the protagonist in Phyllis Reynolds Naylor's Shiloh trilogy. In the second book, Shiloh Season, Marty's nice new teacher has a talk with him while giving back reports on possible careers. She marked many corrections on his report although Mary and his friend got good grades after talking to professionals for their research. The teacher gently tells Marty that in her family, similar to his; she likes relaxing during family visits and talking their "personal talk; family talk," which "is slow and quiet and as soft and beautiful as a summer


as "Top of the morning to you, Little Missy," in dialogue that is sometimes overly familiar and sometimes overly formal. Flossie starts to mock his arrogant diction in her retorts. When he says, "I beg your pardon," she responds, "You can beg all you wanna….That still don't make you no fox." He begins to stutter and plead for a chance to prove himself. Christine Doyle observed that "the fox's language more or less disintegrates as he gets flustered—he stutters, stammers—it's not dialect, but disintegration." He's "a snob" who "loses his sense of identity" while Flossie "keeps speaking just the way she speaks!"

Betty Bacon's excellent essay "'I Play It Cool and Dig All Jive': Languages in Children's Books" criticizes adults who think minority or working class kids have inferiorhis language, and in India a native was always pleased if you knew his speech."

Chili Sue Mahoney, the narrator and twelve-year-old protagonist, collects new words in a notebook, "words we don't use around here," as well as reading lots of books (p. 21).

Chili's seventh-grade teacher Mrs. Sturdivant, from Chicago, expresses unfortunate attitudes about Kentucky language but she leaves to have a baby at the beginning of the novel. "She said we had to do grammar double time. 'You butcher the English language down here,' she said, emphasizing down here as if it was a bad word, instead of just saying Kentucky. Mrs. Sturdivant's from Chicago, where people talk proper without doing language double time" (p. 6).

"I don't like math. I hate numbers. Numbers are not like words. Words


Comment 24 for bug 682788

My opinion: Fitts' law is overrated and people are taking it as gospel while ignoring much more important factors.

Fitts' law says that it is easier to move the mouse to menus located at the top of the screen because you don't have to carefully aim in the vertical direction -- you can just ram it up there and let it hit the top of the screen. Sounds logical, right? Well, consider the following:

1. Have you ever found it difficult to click on in-window menus? Is this actually a problem? I really don't think it is.

2. How often do people actually use menus these days? The menus are the place where developers shove all the rarely-used options. The actual action takes place inside the window.mostly on health and youth development projects. The views expressed here are my own. They do not reflect the position of the U.S. Government, the Peace Corps, or any other organization.
Email me at cvbasham(at)gmail.com


inspired the film Edge of Tomorrow – and it’s bloody brilliant. Different than the movie, featuring a younger protagonist, I loved the deeper backstory the manga gives for mimics and protagonists (especially Rita). The ending is VERY different, should be discussed – but I liked it.

Rating: 7 – Very Good

Final Thoughts:

Another amazing year of feats of strength – I loved every single book (and movie) I picked up! I cannot believe that I dragged my feed so long on The School for Good and Evil – you best believe I will be reading book 2 very soon, and devoting many, many more words to this very clever series. I loved The Silence of Medair, and cannot wait for the next book – Andrea K Host never fails to0.87, 95% confidence interval [CI] = 0.82-0.93), but physical activity level was not associated with incident disability (HR = 0.98, 95% CI = 0.95-1.01). Gait speed was associated with mortality risk in the model without physical activity (HR = 0.93, 95% CI = 0.88-1.00). When gait speed and physical activity were both included in the model, gait speed was not associated with mortality (HR = 0.95, 95% CI = 0.89-1.02) but physical activity was associated with mortality (HR = 0.95, 95% CI = 0.92-0.99). Physical activity was a mediating factor in the association between gait speed and mortality (Sobel test p = .025). Gait speed is directly associated with incident disability and is indirectly related to mortality through physical activity in older adults.


BANNING CONTRACTORS

QUESTION:
Is it permissible to blacklist a contractor in our newsletter or would we need to say something to the
effect of "Contact a board member for a list of contractors who've done a
good job and ones to avoid"?

ANSWER:
This comes up from time-to-time in associations I represent. It happens
more often in condominium developments because of common elements
inside condo walls. Following are your options:

Good Contractors.
Associations can keep a list of "recommended" vendors (such as
electricians and plumbers) for owners to use. Doing so has two benefits:
(i) it's a great convenience to owners who have no idea who to hire and
(ii) you get vendors who are familiar with the development, do good
work, and are properly licensed and insured (assuming the association
screened them).

Bad Contractors. When it comes to "bad" contractors, associations have severala much lower price.

The suggested deal was outlined in a Tuesday article by Anita Kumar, a reporter for the McClatchy news service. She uses the Democrats’ term ‘dreamers’ – to describe the 800,000 DACA illegals as she wrote:

White House officials want Trump to strike an ambitious deal with Congress that offers Dreamers protection in exchange for legislation that pays for a border wall and more detention facilities, curbs legal immigration and implements E-verify, an online system that allows businesses to check immigration status, according to a half-dozen people familiar with situation, most involved with the negotiations. The group includes former and current White House chiefs of staff, Reince Priebus and John Kelly, the president’s daughter, Ivanka Trump, and her husband, Jared Kushner, who both serve as presidential advisers,


increasingly reliant on H-1B foreigners and immigrants for the technology that is needed to grow per-capita income, per-capita productivity, military power and overall economic clout in the face of rising threats from China and other international problems.

However, Trump has announced his strong support for the pro-American “RAISE Act” which would reduce cheap-labor immigration, cut government spending, raise wages and so shift the nation’s economy away from a reliance on imported consumers and towards a greater reliance on high-tech development and workplace automation.

Democrats are going to reject any plausible deal until Trump and his aides wind down the DACA amnesty, said Mark Krikorian, director of the Center for Immigration Studies. “I don’t see that the Democrats are interested in negotiating unless DACA is not actually threatened … why wouldopinion show why immigration reformers won the 2013 “Gang of Eight” immigration debate, the 2014 Senate elections — which likely will keep Schumer minority leader for at least six years — plus the 2016 presidential vote. Trump’s “Buy American, Hire American” policies are also extremely popular, including among Democratic-leaning voters.

“Hold them accountable in the court of public opinion,” said Mehlman, adding that Trump should also press GOP leaders to pressure Democratic leaders. In the Senate, “there are 10 Democrats up for election next year in states that went for Trump… [GOP leaders] have leverage if they choose to use [but] they’re not choosing to use it.”

The Democrats are resisting the “no brainer” popular border-and-enforcement politics that protect the nation from illegal immigration and drugs, said Jenks. “If the


case Palermo will claim that, when Pastore was still with Argentina's Atlético Huracán, they ceded a portion of his economic rights to Simonian's Dodici Sports Management. Then, Palermo will say, when he joined them a deal was agreed whereby Dodici would receive a portion of any future transfer fee. This is perhaps up to half of the total fee due – if so, more than £18.5m.

Now the Sicilian courts are considering a complaint from Palermo alleging Simonian is "extorting" the money from them. They claim Simonian told Pastore that he should not sign for PSG unless Palermo agreed to pay over his half of the fee. Simonian denies that charge, claiming also he owned all of Pastore's "economic rights" until he sold half to Palermo and is thereforeneuritogenesis, and polarity) in comparison to a planar PPX sample. We demonstrate that the nanostructures facilitates an enhancement in neurite branching as well as elongation of axons and growth cones. Furthermore, we show for the first time that the asymmetric orientation of polymeric nanocolumns strongly influences the initiation direction of the axon formation. These results evidence that 3D nano-topographies can significantly change neural development and can be used to engineer axon elongation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1634-1645, 2018.


Q:

Pass several variable to a function Jquery

Noob question incoming: Im using the jquery function loadNewPicture() to load picture (obviously) and the function progress() to see the achievement in percent of the upload.
Everything is working fine.
My question concerns only the variables that I can pass to the function "progress()." This function is a template that I took somewhere. It passes fine the variable "e" without specifiying it when using it by default:
myXhr.upload.addEventListener('progress', progress, false);
But I dont know how to pass more variables.
I would like to pass the variable "category" so I was expecting something like this:
myXhr.upload.addEventListener('progress', progress(e, category), false);
But it does not work.
Any idea?
function loadNewPicture(category, idT)
                    //id pour l'element queExtreme Nature Tours

Smugglers’ Notch Winter Adventures

Sterling Ice Cliff

Peak Expeditions is pleased to offer a pay per climb experience on the ice cliff of Sterling Mountain at Smuggler’s Notch Resort. Just a ski lift ride away is one of the most adventurous thrills of a lifetime. Ride and ski directly to the cliff. Strap on some crampons, grab some ice axes and give ice climbing a try with our experienced staff. $9 per climb or 3 consecutive climbs for $24, equipment provided, ages 11 & older. Must have valid lift ticket, accessible by chairlift only. Ice climbing tickets can be purchased at the Base Lodge or Village Center ticket booths. Weather permitting.

Private Ice Instruction & Guiding

Private climbing experiences can be arranged for Smugglers Notch ice venues. Tope roping with


small groups of family and friends and multi-pitch guiding for private and semi-private can be accommodated. Please inquire for rates and to make reservations. 802-468-PEAK

Winter Via Ferrata

Use and learn technical rope techniques such as Zip-lines, Rappels and Tyrolean traverses to experience some of Vermont’s most unique natural environments up close and personal. Tours take place around, above and in some of the most scenic chasms in the area. All technical safety equipment will be provided. Please inquire for rates and to make reservations. 802-468-PEAK

Other Winter Adventures

Avalanche Beacon Park

Have you ever thought about what it would be like to experience an avalanche? With more recreational skiers and riders traveling into the backcountry, now is the time to learn about snow safety. Anyone traveling into backcountry terrain should be carryingTop roping with small groups of family and friends and multi-pitch guiding for private and semi-private groups can be accommodated. We offer climbing at numerous venues throughout New England from the White Mountains to the Adirondaks as well as Massachusetts. Rates start at $240 for 1 person multi-pitch, $155 each for single non multi-pitch, small groups of three $110 per person. Larger groups can easily be arranged by appointment please inquire.

Smugglers’ Waterfall Rappelling Adventure

The Smugglers’ Notch Waterfall is one of the Notches most prominent features. Standing high over the Notch (and higher still over the valley floor) the top of this 200+ rocky waterfall (the tallest in the state) makes for a perfect viewing point for some of Vermont’s most beautiful and rugged scenery. After taking it all


Q:

Redirect to download Django

I want to track how many times file has been downloaded. I see it this way:
1) Instead of ..., I should redirect user for download view; ...

file.id and file.name needed for proper work of function bellow.

2) In my download view I need to registrate download of specific file, let's say I have registrate_dl function that does its job. Also, I need to take that {{ file.url }} value like in first link from first paragraph.
3) Finally, I registered download for specific file and got {{ file.url }} as file_url variable.
But, if, at the end of view function I place return redirect(file_url), it just redirects me to file, without starting download.

So, how should i return thisthe interface in a straightforward manner [@Kockelkoren03; @Fenton05], and to impose arbitrary boundary conditions at the border of a physical domain of complex shape, see [@Bueno-Orovio06; @Li09] and references therein.

The problem of representing a complex interface through a diffuse boundary gains additional relevance because the use of tomographic methods for structure determination becomes more and more widespread. In such methods, the structure representation takes the form of a matrix consisting of discrete pixels (or voxels in three dimensions) that contain binary or intensity data indicating whether a point in space is “filled” or “empty”. From these data, the “true” structure (represented for example by discrete sharp surface elements) has to be reconstructed by image analysis techniques. The phase-field method is an easy and robust method to obtain a


bulk and at the surfaces, and for a time-independent solution (steady-state flow) reads $$\nabla \cdot \bi{j} = 0.
\label{eq_Poisson}$$ The problem specification is completed by a boundary condition for the potential at the interfaces. We assume continuity of the potential, $$V_+ = V_-,
\label{continuity}$$ where $V_+$ and $V_-$ are the values of the potential when the interface is approached from the two sides. This corresponds to a rapid exchange of the transported quantity between the two sides of the interface.

Since we consider a fixed and immobile two-phase structure, the phase field is independent of time. We will assume that the two constant values that designate the two phases are $\phi=0$ and $\phi=1$, and that the field $\phi$ varies between these two limits continuously through a front region of width $W$. \int_0^1 j_x(1,y)\, dy %\sim h \sum_{j=1}^n j_{x\, n,j},$$ and by plotting $J$ as a function of the ratio $\epsilon=W/R$ between the interface width $W$ and the radius of the disk $R$, see Fig. \[fig\_1\]. As shown in Fig. \[fig\_1\], the three interpolations converge to the same value of $J_0$ when $\epsilon \to 0$. The estimation of $J_0$ is given by a quadratic regression in $\epsilon$ of the simulation data. The coefficients of the regressions are listed in Table \[tab\_1\]. Within the truncation error \[that is ${\rm O}\left( h^2\right) \sim 10^{-6}$\] the three interpolations give the same value of $J_0 = 1.752750\pm 10^{-6}$, as shown in the second column of Table \[tab\_1\].

In addition, we have estimated the rate of convergence of $J(\epsilon)$ to the sharp-interface limit $J_0$ for the three interpolations of


the mobility. As shown in Fig. \[fig\_2\], the direct and inverse interpolations converge only linearly with $\epsilon$ to this limiting value, whereas the tensorial interpolation suppress linear thin-interface effects, which leads to a convergence that is almost quadratic in $\epsilon$.

For further illustration, we consider a second geometrical configuration formed by two half-disks of radius $R$ placed in a rectangular domain with the same boundary condition of the spherical inclusion problem, see Fig. \[fig\_4\]. We choose a small value of the ratio between $M$ inside and outside the half-disks, e.g. $M_2/M_1 = 0.1$, and in Fig. \[fig\_4\] we plot the streamlines for this configuration. In this configuration, the flux is constricted in the narrow space between the two half disks. The difference between the three interpolations is largest for streamlines which are locallydimensions. , 57(4):4323–4349, 1998.

R. F. Almgren. Second-order phase field asymptotics for unequal conductivities. , 59:2086–2107, 1999.

A. Karma. Phase-field formulation for quantitative modeling of alloy solidification. , 87(10):115701, 2001.

B. Echebarria, R. Folch, A. Karma, and M. Plapp. Quantitative phase-field model of alloy solidification. , 70(6):061604, 2004.

R. Folch and M. Plapp. Quantitative phase-field modeling of two-phase solidification. , 72(1):011602, 2005.

M. Ohno and K. Matsuura. Quantitative phase-field modeling for dilute alloy solidification involving diffusion in the solid. , 79(3):031603, 2009.

M. Plapp. . , [91]{}:[25–44]{}, [2011]{}.

J. Kockelkoren, H. Levine, and W.-J. Rappel. Computational approach for modeling intra- and extracellular dynamics. , 68:037702, Sep 2003.

Flavio H. Fenton, Elizabeth M. Cherry, Alain Karma, and Wouter-Jan Rappel. Modeling wave propagation in realistic heart geometries using the phase-field method. , 15(1):013502, 2005.

Alfonso Bueno-Orovio, V団tor M. P屍ez-Garc誕, and Flavio H. Fenton. Spectral methods for partial differential equations in irregular domains: The spectral smoothed boundary


+ "").ToList();
        ICollection<string> sub = _calculate(lenght - 1);
        return (from alpha in Alphabet from prior in sub select alpha + prior).ToList();
    }

    public ICollection<string> Calculate(int lenght)
    {
        return Alphabet == null ? null : _calculate(lenght);
    }
}

biodiversity acceptable,

There's no loss of biodiversity from CO2 unless there's climate change, so you
don't get to throw that in.

> three quarters of the land based biomes on this planet have been
> dramatically influenced by our actions.

That's a combination of poverty and population. Reducing poverty increases CO2
emissions. Since you oppose that, you're arguing for reducing population. Who
do you think should get to live?

Which reminds me - we're not significantly changing the amount of cultivated
land. That ship sailed 1000 years ago. (We are destroying it in the third
world, but that's different.)

> and our gambling with the ecosystem immaterial,

and you're back to assuming man made climate change.

If, as seems increasingly likely, the CO2 changes we're making are irrelevant
to climate, you're advocating spending tons of resources on non-problems.

Acting as if something in


s workplace relations policy
confirmed a move of resources and functions from the ABCC to a
specialist division within the inspectorate of Fair Work
Australia:

The current Australian Building and
Construction Commission arrangements will remain in place until the
31st of January 2010 [ ] At that time, those responsibilities will
be transferred to a specialist division within the inspectorate of
Fair Work Australia [ ] Labor s system will be simpler with the
ABCC and then the specialist inspectorate within Fair Work
Australia ensuring compliance with our tough rules on industrial
action and strike pay. Labor will consult extensively with industry
stakeholders to ensure the transition to new arrangements will be
orderly, effective and robust. The principles of the current
framework that aim to ensure lawful conduct of all participants in
the building and construction industry will continue, as will a
specialist inspectoratefor the building and construction
industry.[26]

the proposed Specialist Division be located within the Office of
the Fair Work Ombudsman but have:

operational autonomy under a Director, appointed by the
Minister, who would implement policies, programs and priorities
determined by an advisory board comprising the Fair Work Ombudsman,
the Director and a number of part-time members appointed by the
Minister; and

funds allocated each year against an Outcome related only to
the Specialist Division.[27]

the provisions of the Fair Work Bill governing:

the conduct

a notice to a person compulsorily to attend for interrogation
be issued only by a presidential member of the Administrative
Appeals Tribunal who is satisfied by written material, which may
include evidence on the basis of information and belief , that:

the Building and Construction Division has commenced an
investigation into a particular suspected contravention, by one or
more building industry participants, of


set at the
standard of the FW Act. Investigatory powers for the ABCC
replacement should be retained, but with appropriate safe guards
and support measures for those required to testify at a building
industry inspectorate investigation.

Item 2 repeals and replaces
section 3, the objects section of the BCII Act.
The change of emphasis in the Bill is reflected in the new objects
section. Whereas the current section is focused on enabling
building work to be carried out fairly, efficiently and
productively the new objects is to provide a balanced framework for
cooperative, productive and harmonious workplace relations in the
building industry .

Item 48 amends the definition
of building work in section 5. The term 'building work' is central
to the BCII Act as it forms the basis of terms such as building
employee and building agreement, and hence terms such
as building employer(the
Building Inspectorate). The staff of the Building Inspectorate
would be engaged under the Public Service Act 1999
(proposed section 26K).

The Building Inspectorate would be headed by a
Director appointed by the Minister (proposed section
9). The Director's functions are set out in
proposedsection 10 and include
the functions of promoting harmonious, productive and cooperative
workplace relations in the building industry and promoting
compliance with designated building laws[66] and the Building Code including by
providing education, assistance and advice to building industry
participants. The Director s functions are drafted broadly. Amongst
other things, he/she may:

investigate suspected contraventions of a designated building
law, a safety net contractual entitlement or the Building Code

institute court proceedings or make applications to FWA
regarding building laws or safety net contractual entitlements as
they relate to building industry participants

refer matters to other relevant authorities

provide representation to a building industry


participant in
court or FWA proceedings if the Director considers that this would
promote compliance

disseminate information, and provide advice and assistance to
building industry participants

make submissions and provide information to the Independent
Assessor[67]

any other functions conferred on the Director by any Act.

A note confirms that the Director also has the
functions of an inspector under proposed section 59A.[68]

These functions correspond in many respects to
the ABC Commissioner s functions, although note the additional
function of inquiring into, investigating, and commencing
proceedings in relation to safety net contractual entitlements as
they relate to the building industry. This provision would enable
the Inspectorate to take action in relation to breaches of a modern
award or the National Employment Standards.[69]

Proposed section 11 provides
that the Minister may give directions to the Director about the
policies, programs and priorities of the Director and about the
mannerapolitical public servants and industry representatives, would
introduce much-needed accountability and balance into the work of
Building Inspectorate.[78] Master Builders, on the other hand, believes the
Advisory Board is unnecessary and will prove to be ineffective,
cause unnecessary delays and may lead to conflict of interest for
the Director over differences in Ministerial directions and Board
recommendations.[79]

Item 51 is one of the most
significant amendments in the Bill. It removes Chapters
5 and 6 of the BCII Act dealing with
unlawful industrial action, coercion and the associated civil
penalties that are specific to the building industry.

The effect of item 51 is that
there would no longer be unlawful industrial action and coercion
provisions specific to the building and construction industry.
Rather, the industrial action control and penalty regime introduced
by the FW Act would apply equally in the case of industrial action
by


of the penalty regime.[85]

ACCI supports the ABC Commissioner s views and
maintains that there are good public policy reasons why existing
penalty provisions and different industrial law provisions should
continue to exist. ACCI submits that equality before the law is not
an absolute principle and should not be the dominant justification
for removing what it believes to be targeted, appropriate and
effective provisions.[86]

Master Builders submission highlights that the
Building Inspectorate will have no separate underlying provisions
to enforce but will be enforcing provisions of the FW Act in the
capacity of an Inspector.

Without dedicated laws to deal with the subject
matter of chapters 5 and 6 and the related penalties for their
breach, the work of the ABCC cannot be continued. Content is not
only important; it is fundamental to the proper functioning of the
successor body.[87]

Master Builders believes that theof the examination powers stating that they
recognise that they amount to an impressive, and much needed, set
of improvements.

In particular, conditioning use of coercive
powers upon the approval of a presidential member of the
Administrative Appeals Tribunal will remove both the possibility
and the perception that the powers may be used for inappropriate,
even ideological, purposes. Other improvements such as the
imposition of a sunset clause, and an expanded role for the
Commonwealth Ombudsman are also highly desirable.

However, we note that even with these
safeguards the coercive powers provided for in the primary Act are
not justified. The safeguards do not, for example, overcome the
fact that the coercive powers can be used in an overly-broad set of
circumstances, such as in regard to non-suspects and children in
the investigation of minor or petty breaches of industrial law and
industrial instruments.


Senate Scrutiny of Bills Committee has
to date made no comment.

Concluding comments

The Bill has evinced entrenched positions from
both sides of Parliament, with the Coalition parties preferring no
change with the BCII Act remaining unamended, while the ALP is
committed to aligning regulation of the building and construction
industry to the general standards pertaining under the FW Act,
while retaining a specialist Fair Work inspectorate to deal with
the building industry. It is therefore difficult to avoid the
premise accepted by Murray Wilcox, that a replacement of the ABCC
needs to be taken as a given, in this debate. The issues of the
proposed inspectorate s coercive powers for conducting examinations
and ascertaining information and whether a site or enterprise needs
to be subject to special regulation, therefore become the focus of
debate. In this context, it becomes difficult to disagreeeffective with synergistic effects when compared with either strategy alone.^[@R12],[@R13]^ Simultaneous expression of CD and UPRT genes could lead to synergistic effects resulting in increased sensitivity to 5-FC.^[@R14],[@R15]^ Among double suicide gene therapy strategies, the combination of HSV1-TK/GCV and CD/5-FC is most widely studied and has been evaluated in clinical trials^[@R16],[@R17]^. Subsequently, a reporter gene system (the human sodium iodide symporter, hNIS) was incorporated into a double suicide gene (TK/CD) adenovirus, and Na^99m^TcO~4~ SPECT images demonstrated gene expression after virus injection into human prostate cancer.^[@R18]^ Thus, it was suggested that MMI can be used to monitor adenovirus-mediated suicide gene therapy.^[@R18]^

The aim of the present preclinical study is to demonstrate that the therapeutic efficacy of the triple-suicide-gene approach is improved relative to previous methods, and that multimodality molecular imaging


can be used to monitor the delivery, and evaluate the distribution and function/activity of the triple-suicide-gene.

Material and Methods {#S2}
====================

Plasmids {#S3}
--------

Three plasmids were constructed: 1) pCMV-TK/eGFP contains the *HSV1-tk* and *egfp* fusion gene under the control of a cytomegalovirus (CMV) promoter and a neomycin resistant gene, 2) pCMV-CD/mDsRed containing the *cd* (of *Saccharomyces cervisiae*) and monomeric dsred (*mDsRed*) fusion gene and 3) pCMV-CD/UPRT/mDsRed containing the *cd*, *uprt* (of *Haemophilus influenzae*) and *mDsRed* fusion gene under the control of the CMV promoter. The latter two plasmids contain the hygromycin B resistance gene.^[@R7]^

Cell Cultures and Stably Transfected Cell Lines {#S4}
-----------------------------------------------

R3327-AT rat prostate carcinoma cells were maintained in Dulbecco's Modified Eagle medium (DMEM; Mediatech, Herndon, VA) supplemented with 10% fetal bovine serum, 100 U/ml penicillin and 100 μg/ml streptomycin (Gemini, West Sacramento,performed using a Bruker 7T spectrometer.^[@R9]^ Mice were anesthetized with isoflurane and positioned in a specially designed animal holder. ^19^F MR spectra were acquired and averaged over 10 min before and after the *i.v*. administration of 150mg/kg 5-FU or 5-FC for a maximum of 1 hr using a single pulse with a TR of 1s and sweep width of 15 kHz. A glass sphere (18μl) filled with 75 mmol/L sodium fluoride (NaF) was used as an external reference for quantitation. The MR time domain data were analyzed using XsOs NMR (Columbia University). The spectral area of the acquired data was obtained from a Lorentzian fit to the spectra after line broadening (30Hz). Metabolite ratios were calculated by normalizing their resonance-peak areas to that of NaF. Graphic representation of


home-made animal holder. The treatments were applied once a day for 5 days. Ten mice were used in each group. For six mice, the tumor volume was measured three times a week until the average volume reached \~1500 mm^3^. The tumor volume relative to those at the beginning of treatments was calculated and plotted as a function of time after treatments. The difference in time (days) of tumor volume reaching \~1500 mm^3^ for treated groups relative to controlled group (relative growth delay) was calculated and compared. For other four mice, the tumors were dissected at 24 hr after the last treatment, fixed with 4% paraformaldehyde, embedded with paraffin and cut into 4 μm sections for the immunohistochemistry staining.

Immunohistochemistry Staining and Imaging Acquisition {#S15}
-----------------------------------------------------

The detection of proliferation and apoptosisfor each group.](nihms472911f3){#F3}

![Immunohistochemistry staining of Ki-67 (A) and cleaved Caspase-3 (B)\
This was performed in TKCDUPRT-expressing (top panel) and TKCD-expressing (bottom panel) tumors in untreated mice (control) or in mice injected with GCV (30 mg/kg) and 5-FC (500 mg/kg). The number Ki-67 and CCP3 staining positive cell was counted in 200 μm × 200 μm magnified fields at the composited images (10 fields/each tumor) and compared between treated tumors and controlled tumors. &: *P*\<0.01, \#: *P*\>0.01.](nihms472911f4){#F4}

![Effect of co-expression of TK, CD and UPRT on cellular and tumor response to graded doses of radiation, by itself, or in combination with GCV and 5-FC\
**(A)** Surviving fractions of TKCDUPRT cells (left panel) or TKCD cells (right panel) treated with radiation alone (●), or in combination with GCV (○), 5-FC (▼) or both


Q:

Well-ordering of the reals in ZF with constructibility?

The question Do we know that we can't define a well-ordering of the reals? states:

There exist pointwise definable models of ZFC where every set is definable without parameters: it is the unique element of the model that satisfies some finite formula $\varphi(x)$. So there is a formula $\varphi(x)$ such that
  $$ \tag{*} \forall x(\varphi(x)\rightarrow x\text{ well-orders }\mathbb R) \land \exists ! x\,\varphi(x) $$
  is consistent with ZFC.
  (And it is not difficult to write down a concrete $\varphi$ which will work in a model with $\mathbf V=\mathbf L$).

What is an example of such a $\varphi$?

A:

$L$ has such a nice canonical structure that one can use it to define a global well-ordering. That is, there is a formula $\phi(u,v)$to its first coordinate.) An example of a book discussing $L$ along these lines is

MR0597342 (82f:03001). Kunen, Kenneth. Set theory. An introduction to independence proofs. Studies in Logic and the Foundations of Mathematics, 102. North-Holland Publishing Co., Amsterdam-New York, 1980. xvi+313 pp. ISBN: 0-444-85401-0.

Whichever approach you follow, by the recursion theorem this gives you that there is a formula $\psi$ in one parameter $a$ that, whenever $a$ is an ordinal $\alpha$, defines $L_\alpha$. That is, $\psi(a,x)$ has the property that (provably in $\mathsf{ZFC}$, although it suffices for what we are doing here that this is true under the assumption of $V=L$) for any ordinal $\alpha$, the set $L_\alpha$ is the unique set $b$ such that $\psi(\alpha,b)$ holds.
In the sketch below, I follow the first approach. I'm


Archive for December 30th, 2009

I hate it when I am right on matters of life and death, when the conclusion is we could see a lot more death in our immediate future. I took a lot of heat when President Obama came to office hoping he would succeed. I did this because I knew his failure would have dangerous […]

I knew it would not take too long before deep sources inside the intel community would start to spill the beans about changes the liberal Obama administration made to our national security apparatus that were the likely (and I emphasize that for now) cause for terrorists having more success in hitting us in 2009 than […]

It finally happened – as so many of us predicted it would. The Flightattribute:(NSLayoutAttribute)attr2 multiplier:(CGFloat)multiplier constant:(CGFloat)c API_AVAILABLE(macos(10.7), ios(6.0), tvos(9.0));

/* If a constraint's priority level is less than required, then it is optional.  Higher priority constraints are met before lower priority constraints.
 Constraint satisfaction is not all or nothing.  If a constraint 'a == b' is optional, that means we will attempt to minimize 'abs(a-b)'.
 This property may only be modified as part of initial set up or when optional.  After a constraint has been added to a view, an exception will be thrown if the priority is changed from/to NSLayoutPriorityRequired.
 */
#if TARGET_OS_IPHONE
@property UILayoutPriority priority;
#else
@property NSLayoutPriority priority;
#endif

/* When a view is archived, it archives some but not all constraints in its -constraints array.  The value of shouldBeArchived informs the view if a particular constraint should be archived by


-- Dave, our librarian, just brought it to our attention. Apparently, your physical presence is somehow tied to the continuing monster attacks in the kingdom. As long as you remain on this plane of existence, the attacks will continue. It seems that it wasn't just the Sorceress -- the monsters just really, really don't like you.

I don't suppose you'd bugger off this mortal coil, would you? Our instruments (especially the tuba) show there's a rip in the fabric of reality that appeared when you fought the Sorceress. If you jump in there, you'll ascend to a higher plane and peace will rule our land."

King Ralph

Sorceress' Chamber

You shout "Hi-keeba!" and deliver a fierce karate chop to the prism. It shatters into a quintillion tiny pieces of magic, which whirlthat joined the two armies during the battle for the Nearby Plains. The symptoms described sound eerily similar to the plague that's been infecting our population in the present time.

The bad news is: the journal says that, left uncured, the Gray Plague turns those infected with it into mindless, slavering zombies. The good news is: the military doctors were able to formulate a vaccine for the Gray Plague. The other bad news is: the primary ingredient for the cure is a certain gland found in the heads of the aforementioned zombies.

However, we've been able to come up with a solution. Don't ask how, but we've managed to create a rift that leads to a temporal location of our choosing, to wit: the Seaside Town, 28 days from now,


In the prior art, an electronic device, for example, a surface-mount crystal oscillator is configured by mounting a crystal resonator 13 and circuit components 14 on a principal surface of a base board 10 and covering the base board 10 with a metal cover 9 from the upside as shown in FIG. 9.
Here, in order to install the metal cover 9 in the base board 10, protrusions 11 are provided on the side surface of the metal cover 9, and bulging portions (claw) 12 extend downwardly from the protrusions 11. In addition, the protrusions 11 abut on the outer circumferential surface of the base board 10, and the bulging portions 12 extending downwardly from the protrusions 11 are inserted into the notches 18 formed on the side surfaceJoe Staley could get the veteran courtesy nod, but I can't think of anybody else on offense that is worthy of a Pro Bowl spot. On defense, I could definitely see NaVorro Bowman getting a spot on the team. Aaron Lynch leads the team with six sacks, and is second in the NFL in quarterback pressures. I doubt he gets the fan vote, but the coach and player vote could be enough for him.

Anybody else even close to worthy this year?

NFL ALL-STAR TOP-TEN VOTE-GETTERS

POS. NAME, TEAM VOTES QB Tom Brady, New England 141,750 QB Aaron Rodgers, Green Bay 120,242 QB Andy Dalton, Cincinnati 114,368 RB Devonta Freeman, Atlanta 103,334 TE Rob Gronkowski, New England 101,674 QB Cam Newton, Carolina 94,810 QB Carson Palmer, Arizona 87,838 WR Julio Jones,


    else if (tokens[1].equals("SemesterGrades")) {

                CSDriver.checkSemesterGrades(tokens, students);
            }
        }           else
            System.out.println("something is wrong!");

    }

    scan.close();
}   }

A:

You are not getting anything from scan because you already closed System.in (when closing scan2, at the end of the "login succeed" part). You should not close it yourself, as it prevent any future attempt to read from this stream.

conclusions of Humphreys et al., the emission-lines [*are*]{} variable when viewed from different angles. It is argued that this is due to the non-isotropic nature of the star’s wind, and that the line-emission is formed in an axi-symmetric structure in the inner wind.

We begin in Sect. \[sec:ifuobs\] with a description of the observations, data-reduction steps and analysis techniques. The results of the data analysis are presented and discussed in Sect.\[sec:ifuresults\], and summarized in Sect. \[sec:ifuconc\].

Observations & Data-Reduction {#sec:ifuobs}
=============================

Observations
------------

Data was taken during 3-5 September 2005 at the WHT on La Palma, using [*OASIS*]{} in [*Tiger*]{} mode [@Bacon95] in conjuction with the [*NAOMI*]{} adaptive optics system [@Myers03]. Observing conditions were good, with a small amount of extinction ($\sim$ few tenths of 1 mag) due to Saharan dust. Seeing was 0.6-1.0throughout our programme.

The


identified neon lines in the observed wavelength range. When identifying and rejecting cosmic rays, it was found that the [xoasis]{} algorithm was unable to deal with the high number of hits without attacking the H$\alpha$ line centre. Instead, cosmics were rejected at the mosaicing stage.

To mosaic the 17 individual frames, each were first recentered about the brightness-centre of each exposure. The frames were weighted according to the mean number of counts per frame, and resampled onto a square spatial sampling grid using bicubic interpolation. The median spectrum was then found at each spatial point on the grid, thus eliminating cosmic ray hits. As the observations were dithered by $\sim$0.1, we chose to spatially sample the individual frames onto a master grid of 0.13per pixel, i.e. half the sizeare listed in Table \[tab:ifuspec\].

The spectral features identified in Table 1 do not all exhibit the same behaviour across the field. Below, we emphasize this by showing the residual spectrum between the central star and the surrounding nebula. This is followed by a discussion of the behaviour of individual lines. As the signal-to-noise (S/N) of the lines falls-off with distance from the star, this analysis is limited to those with the highest S/N, in order to assess the spatial variations over as large a field as possible. These features are the H$\alpha$, Fe [ii]{} and Ti [ii]{} emission lines, as well as the unidentified blend at $\sim6610$Å and the diffuse interstellar bands (DIBs).

![Definition of the 9 spatial regions over which the spectra were integrated. []{data-label="fig:spregmap"}](fig2.eps){width="12cm"}

![The residual spectrum (solid line)


equivalent width of the line is constant over the field to within the errors. However, the S/N in the outer regions is low, and for this reason it is not illustrated here.

The cancellation of the DIBs in the residual spectrum is an important result. These features are indicative of the interstellar extinction toward IRC +10420 [@Oudmaijer98], and appear to be equally strong towards the central star and the outer nebula. This supports the conclusions of @Jones93 who found that, whilst the star has significant IR-excess, there is only a relatively small amount of [*circumstellar*]{} extinction in the line-of-sight to the central star. In addition, this result strongly suggests that any variations observed in other spectral features are real.

The H$\alpha$ and Fe [ii]{} $\lambda$6516 emission
--------------------------------------------------

The H$\alpha$ and Fe [ii]{} emission,and Ti [ii]{} $\lambda$6607.

By taking a slice across the data-cube at a PA of 33 i.e.aligned with the symmetry identified from the H$\alpha$ [$W_{\lambda}$]{} map, a synthetic long-slit spectrogram of this feature was created (see Fig.\[fig:unls\]). The figure shows the feature on the blue side of the DIB apparently behaving identically to the Ti [ii]{} lines, i.e. concentrated in the centre of the field. This is strong evidence that this feature is in part due to Ti [ii]{} emission, as suggested by @Chentsov99. This feature [*completely*]{} vanishes to the south, implying that all the unidentified, unresolved emission components which make up this feature behave in the same way.

The spectrogram of this region also reveals the behaviour of the unidentified feature on the red side of the DIB. This feature is strongest


Q:

How to create a hierarchy Menu/Icon

I dont know if the question represent exactly what i want to ask, but i could`t figure how else to name what i want to do.
So im trying to create a 3x3 grid  and in every cell i have a image.
I can click on any of the 2nd cell of a column only if the 1st of the same column has been clicked before that.What i mean is
i can click cell No:5 only if 4 has been clicked before that
i can click cell No:9 only if 8 and 7 has been clicked before that
i can click cell No:1,4,7 anytime.
and also when they are clicked their alpha gets to 0.1 (so i know that the cell has been clicked.)

currently i the logicsector has been felt by increased sales to China, it hasn't been enough to offset the industry's dependence on the U.S. housing market. Although mortgage rates are currently low, the high levels of unemployment frighten or inhibit builders' ability to receive credit. Low demand for wood has also hurt prices. Visit www.stockcall.com/ to see how companies in this industry have grown over the past years and how they are expected to perform in the future.

However, a small glimmer of hope sparkled throughout the industry this August when housing starts increased 10.5%. This data combined with the anticipation of higher prices and a decreased Canada to U.S. export tax could cause the industry to return to modest profitability in 2011. Register now at https://stockcall.com/development/stockcall/page.php?name=register.html to have free access to


         int elementsPosition = 0;
            for (int position = 0; position < expectedValues.length; position++) {
                T expectedRow = expectedValues[position];
                assertEquals(columnarRow.isNull(position), expectedRow == null);
                if (expectedRow == null) {
                    continue;
                }

baby's first year, and an "is it safe?" tool to answer safety-related questions about pregnancy.

Awards and recognition
In 1998, BabyCenter won a Webby Award for Best Home Site. Since then, it has been nominated for a Webby Award 18 more times and won either a Webby or a People's Choice Webby Award 11 times – including a People's Voice win in 2016 for Best Family/Parenting website.

BabyCenter has also won awards for its editorial content. In 2015, BabyCenter won five Digital Health Awards for content about autism in children. In 2016, BabyCenter won seven Digital Health Awards: four for videos about the aches and pains of pregnancy, baby sleep, and the walking milestone in child development; two for articles about baby sleep training and sleep apnea in babies; and one


IList<ProductVariantAttributeModel> ProductVariantAttributes { get; set; }
        public class ProductVariantPriceModel : BaseNopModel
        {
            public string OldPrice { get; set; }

            public string Price { get; set; }
            public string PriceWithDiscount { get; set; }

            public decimal PriceValue { get; set; }
            public decimal PriceWithDiscountValue { get; set; }

            publiccould use the original test after throwing away one of its ingredients, which had never been essential to the test's function.

"In a public-health emergency, it's kind of ironic that all the states had a test that worked. They just didn't have a protocol that worked," Alex Greninger, the assistant director of the University of Washington Medicine Clinical Virology Laboratory, told Business Insider. "What changed was they just said, don't use that reagent."

Delays in testing have most likely allowed the coronavirus to spread throughout the country, since limited testing makes it harder for health officials to find, isolate, and trace infected patients. More than 200 people in the US have died from COVID-19 and nearly 14,000 have been infected, compared with just dozens of cases reported in February. All


lot of them, it takes more time to do a test, but you have higher accuracy," a representative for the Wisconsin lab told Business Insider.

By the time the FDA approved the coronavirus test, the CDC was investigating about 260 patients, using samples that had been sent to its headquarters in Atlanta. Eleven people had already tested positive across five states. On February 6 and 7, the CDC shipped 90 test kits to state public-health labs.

But one of the CDC's reagents turned out to be faulty, causing most of the state labs to come up with inconclusive test results. The Washington State Public Health Lab was among those that received shipments containing the defective reagent. The state reported the first COVID-19 case in the US and is now oneonly for people with symptoms so severe that they required hospitalization, people who had recently traveled to countries with high case totals (like China or Iran), or people who had been in contact with someone confirmed to have the coronavirus.

A representative for the Wisconsin lab said it had the capacity to test people starting February 28, but no cases in the state met the CDC's criteria until March 2. By that point, 90 cases had been confirmed nationwide, though that's probably an underestimate. (According to researchers at the Seattle Flu Study, there were probably already about 570 coronavirus cases in in the greater Seattle area by March 1, mostly connected to the first COVID-19 patient.)

'By the time they send things out, it ought to be foolproof'

Greninger said one


instead by its new Face ID technology, but we still certainly appreciate this alternative form of security.

Display

Apple might’ve moved beyond 1080p resolution with the iPhone X, which flaunts a 5.8-inch 1125 x 2436 Super Retina Display that leverage OLED technology, but the V30 is still technically more pixel packed with its larger 6-inch 1440 x 2880 FullVision P-OLED display. Not surprisingly, they hopped on the trend of boasting that near bezel-less look with their fancy looking new displays, so they’re more than equipped for all of your multimedia consumption.

Briefly comparing the two, it’s tough to make enough of an assertive affirmation about which one is more superior, but we can definitely say that the viewing angles on the iPhone X‘s display is better. For now, we’ll be reservedwith Dartmouth Medical School’s Center for Global Health to launch this campaign. “I am TB” is a group of individuals affected by TB and their physicians, who have come together to reduce stigma around the disease and improve rates of TB testing and treatment. It aims to promote positive images of people with TB. The campaign messages incorporate the letters “TB” and do so by associating them with favorable images and words, for example "The Best," "The Beautiful," and "The Brave". The campaign also encourages physicians, scientists, and global agencies to increase efforts aimed at TB elimination. This campaign is collaborative in nature, bringing together both those affected by the disease and those who treating them – a partnership not often seen in this patient population.
The campaign’s United


to join us in condemning these latest actions and to insist on a political process to end the violence in Syria. All those with influence on the Syrian regime should bring it to bear now. No nation should stand silent while people in Aleppo are threatened with a potential massacre.

“This dire situation illustrates very strongly why the people of Syria needed the UN Security Council Resolution we proposed last week.

“The regime should be in no doubt that the world is watching its actions, and that those responsible for the crimes being committed will one day be held to account.”Planned Parenthood from being targeted for defunding by conservative politicians in the failed replacement bill for the Affordable Healthcare Act, also known as Obamacare.

While the pair have gained prominence for their access to the President, it has disappointed former allies.

A political consultant told the magazine: “You can’t prevent him from trying to de-fund Planned Parenthood or getting out of the Paris agreement? What are you good for?”

Some of the couple’s former friends in New York’s Democratic leaning elite have also reportedly rejected them because of their political career and relationship to the President, particularly after he failed to condemn far right protesters in Charlottesville.

“I haven’t had anything to do with them since they moved,” a former friend told the magazine.

“And it is because the day that man [Mr


Mr Kushner’s days in the White House are numbered.

There is reportedly speculation they are already preparing an exit plan, to be enacted in summer 2018.

This is likely to be dressed up as family concerns but would likely come amid further problems in the White House, it is predicted.Empty placeholder for easier customization. -->
        <!-- You can override this target in the ../build.xml file. -->
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    <target depends="-pre-init,-init-private" name="-init-user">
        <property file="${user.properties.file}"/>
        <!-- The two properties below are usually overridden -->
        <!-- by the active platform. Just a fallback. -->
        <property name="default.javac.source" value="1.4"/>


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        <property name="javac.fork" value="false"/>
    </target>
    <target name="-post-init">
        <!-- Empty placeholder for easier customization. -->
        <!-- You can override this target in the ../build.xml file. -->
    </target>
    <target depends="-pre-init,-init-private,-init-user,-init-project,-do-init" name="-init-check">
        <fail unless="src.dir">Must set src.dir</fail>
        <fail unless="test.src.dir">Must set test.src.dir</fail>
        <fail unless="build.dir">Must set build.dir</fail>
        <fail unless="dist.dir">Must set dist.dir</fail>
        <fail unless="build.classes.dir">Must set build.classes.dir</fail>
        <fail unless="dist.javadoc.dir">Must set  <path path="@{classpath}"/>
                    </classpath>
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                    </syspropertyset>


repairs were made to the subject aircraft during that month and on which document the plaintiff's name and address appears in the space designated for the name and address of the owner of the aircraft.
17. In May 1960, a document entitled "Aircraft Use and Inspection Report", FAA Form ACA No. 2850, was filed with the Federal Aviation Agency and on which document T. H. Lackey certified that a periodic inspection of the aircraft had been conducted on May 5, 1960, and that the aircraft was airworthy. On the document the plaintiff's name and address appears in the space designated for the name and address of the owner of the aircraft.
18. These documents were eventually placed in the same file as were the documents relating to title to, anduntil October 6, 1960. Defendants[2] assert that they had no actual knowledge of the prior unrecorded sale to the plaintiff, and that under the statute their title is superior to that of the plaintiff. Plaintiff seeks to be excused from the consequences flowing from his later recordation on the ground that the defendants had "actual notice" of the prior conveyance to plaintiff within the meaning of the statute.[3]
All the evidence in this case indicates that defendants did not have actual notice of plaintiff's purchase of the aircraft in the sense of having actual knowledge of that fact, or in the sense of being aware of its existence. When requested by interrogatories to provide the defendants with the names and addresses of witnesses who would testify to actual notice


No conveyance or instrument the recording of which is provided for by subsection (a) of this section shall be valid in respect of such aircraft, aircraft engines, propellers, appliances, or spare parts against any person other than the person by whom the conveyance or other instrument is made or given, his heir or devisee, or any person having actual notice thereof, until such conveyance or other instrument is filed for recordation in the office of the Administrator * * *
"Effect of recording
"(d) Each conveyance or other instrument recorded by means of or under the system provided for in subsection (a) or (b) of this section shall from the time of its filing for recordation be valid as to all persons without further or other recordation, except that anbusiness. Express knowledge that the plane was in the possession of plaintiff at the time their mortgage was placed on it might not therefore put them on notice of his claim even if known by defendants. Plaintiff's possession was consistent with the possibility that he had chartered the plane from Southern Fight Service, Inc.
[8]  Plaintiff also contends that an "Aircraft Use and Inspection Report," dated April 5, 1960, and listing the plaintiff in the space designated for the owner, was also in the file and should have been seen by the title examiner. But the stamp on the document indicates it was filed on May 19, 1960, and the defendants had already advanced money to the defendant Southern Flight Service on May 18, 1960, relying on a


Q:

Is there a memset() function for 16 and/or 32 bit values?

memset() is very fast, as it benefits from stosb op code internally.
Is there a function for 16 and 32 bit values which similar efficiently benefits from stosb, stosw and/or stosd?
wmemset() is not portable and does not help on 16 bit values.

A:

There is no such function in standard C, but depending on what you're trying to do, there may be CPU-specific SIMD "intrinsic functions" that you can use to build one.  Your mention of stosb makes me think you're using an x86, so review the documentation for the various *mmintrin.h headers and the functions they provide.

more like a crocodile than a fish. It eats, and sometimes holds things in its jaws or gullet, despoiting them in a larder for later consumption. Which is why Hyun-seo survives her captivity for so long.

The children, Hyun-seo and another child who joins her in captivity, stand as a stark contrast to the ones in the early Gamera films. The children are its victims, not its cheerleaders.

Joon-ho Bong has an excellent sence for human drama. As crowds panic and flee the creature, Gang-doo grabs his daughter's hand and runs. He slips, falls, then grabs her hand again and keeps running. A moment later, he looks back and sees that he has grabbed the wrong hand. Hyun-seo is far behind, alone, directly in the path of the creature. It's


in fog, for example. But the primary text is clearly the original Willis O'Brien/Merian Cooper/Ernest B. Schoedsack film. Only expanded. A lot. The 1933 version runs a hundred and four minutes. Jackson's full remake is a full hour and forty minutes longer, clocking in at a whopping two hundred and four.

Despite the gorgeous scenery and lush color, the film features more black and white characterization than the original. Carl Denham, played by Jack Black, is a sleazy opportunist, and perfectly in character with the times. Denham was an opportunist in 1933, and the film touches only lightly on his past as a film maker. 1933 Denham is respected, freely given the money for his trip to Skull Island. In 2005, Denham is a maverick, and there are parallelsa narrow alley towards the humans. It all ends in a gigantic train-wreck pile-up of dinosaurs, having contributed nothing to the plot.

Because this is the second remake, and Kong didn't fight any dinosaurs in the 1976 version, Kong fights three Vastatosaurus rex (which look and feel like a Tyrannosaurus rex). The fight is inventive, partially because Kong has to keep Ann Darrow in one hand and out of danger. But there's a bit of repetition. Where 1933 Kong used the roll and throw once, 2005 Kong uses it three different times.

Jackson of course puts his own spin on the famous log scene, where Kong shakes the tiny humans off a log over an abyss. He also restores the spider-pit scene, a section taken out of the 1933 Kong


unless our churches preach more boldly the fallen and sinful nature of man I have doubts about the outcome.

Still let us rejoice. The exchange rate of the Bank of Heaven is unaltered and our investments there are utterly unshaken. That leads me to a final and more upbeat thought: maybe we need also to preach more, not just about sin but also about heaven.Kundalini Horoscope: September 3 – 9

The Moon is waning this week. She starts out at half mast – rising at midnight and setting at noon. With each passing day she will be smaller and smaller in the sky until the exact point on Sunday when she is perfectly in line with the Sun and you won’t see her anymore at all. As a result, all this week our energy will be waning. Our emotional reserves are less and less each day. Our fuses become shorter. Be gentle with others and practice yoga sets that are meditative and inwardly-directed as opposed to the more challenging physical ones.

Monday is Labor Day for those in the US. Happily, the astrological energy is well-aligned for a day off in celebration with friends


and family. The Gemini Moon supports fun, light-hearted active conversation over a wide range of topics. This is a good time to connect with people of many different circles. It is a good time to connect with siblings. Travel plans are favored. A short trip from home will be enjoyed by all.

The energy is quite different on Tuesday with the Moon having switched into sensitive, watery Cancer overnight. Suddenly everyone is more emotional and reserved. We crave to be home and by ourselves with a good book and a home-cooked meal. It may be hard to get up and go to work. The desire is to stay in bed. Go easy on other people. Remember that they are sensitive as well. People are easily hurt by insensitive wordsto die as a direct result of having a seizure. If you happen to be present when the seizure starts, your first priority is usually to ease them onto the ground, the bed, or some other open horizontal surface. This can be difficult to accomplish with any degree of grace or dignity if they're limp or convulsing, and/or if they're too heavy for you to move easily, but do the best you can. Your main priority is to keep their head from smacking into anything, including the floor, while they're on their way down. If they're wearing glasses, remove them as quickly/gently as you can. Remove or loosen bondage, clothing, and/or jewelry as best you can *if* it's causing a problem. For example, given that arms tend to


especially true for ordinary citizens. This is also the most common "formal" training for medical folks. The reality, however, is frequently different. Medical supply companies sell various types of "bite sticks," usually made of firm, but not hard, plastic-like materials. Such sticks are also often improvised by wrapping gauze and/or tape around two or three tongue depressors. The usage of such bite sticks during a seizure by medical folks, ranging from first responders to physicians, is very common. There is even a small, threaded, cone-shaped device used for opening clenched jaws called an "oral screw." (Don't start!) This is one of several areas in medical training that can cause the new student considerable head-scratching. In class, you're told "never do this" and yet when you get out inafter our relationship ended, I still had her teeth marks on my wallet as a very unusual type of relationship memento. I had never been taught to "never do that" and, in fact had been taught *to* "do that." So I did -- many, many times. And I never hurt her jaw, teeth, or anything else by doing so. My consistent experience, both in what I've seen and in what I've done, is that seizure patients _do_ benefit from having something soft (or, at least, something not real hard; *please*, no spoons, pencils, knife blades, etc. we don't want tooth fragments flying about) put between their teeth, and that this can almost always be accomplished without damaging the patient. Placing something soft frequently reduces degree of damage to


hundred times, on patients of many different types, without even one single incident of hurting a patient by doing so. Quite the contrary. They seemed to benefit from the procedure, and patients managed without it didn't seem to do as well. A hopefully useful additional comment is that, while I definitely believe that seizure patients do better with a bite stick in place, I can't say that I ever saw a survivable patient lost because the procedure was not performed. Placing a formal or improvised bite stick is a nice touch, but it's not a matter that usually affects the outcome of the case to a major degree one way or another. Don't give this matter all that much importance, particularly if you're a "civilian." When the paramedicslisted the § 3553(a) factors, finding Cooper's sentence "satisfies the purposes set forth in 18 U.S.C. 3553(a)" and was "reasonable in light of these considerations." Addressing Cooper's request for a lighter sentence, the court stated:

8
But the nature of the offense is so serious. This was a very serious drug trafficking business, which the Defendant was an integral part of it [sic], and I cannot ignore the effects of her involvement in this case on the public and all the users through the years. I don't feel, if I didn't impose a sentence that I intend to impose, I would be fulfilling my obligations as a Judge....

9
It is a serious offense. Let me tell you, you were part and parcel of it for a long period of time, and


considered each of the § 3553(a) factors or to discuss each of the § 3553(a) factors"). Nor will we require district judges to routinely state by rote that they have read the Booker decision or that they know the sentencing guidelines are now advisory.

23
On the other hand, a rote statement of the § 3553(a) factors should not suffice if at sentencing either the defendant or the prosecution properly raises "a ground of recognized legal merit (provided it has a factual basis)" and the court fails to address it. Cunningham, 429 F.3d at 679. As the Court of Appeals for the Seventh Circuit explained, "we have to satisfy ourselves, before we can conclude that the judge did not abuse his discretion, that he exercised his discretion, that is, thathe considered the factors relevant to that exercise."6 Id.; cf. United States v. Johnson, 388 F.3d 96, 101 (3d Cir.2004) (holding "there is no way to review [a court's] exercise of discretion" if it "does not articulate the reasons underlying its decision" and the court's reasons "are not otherwise apparent from the record") (quoting Becker v. ARCO Chem. Co., 207 F.3d 176, 180-81 (3d Cir.2000)).

24
At least one court has held a sentencing judge is presumed to have considered all of the § 3553(a) factors if a sentence is imposed within the applicable guidelines range. United States v. Mares, 402 F.3d 511, 519 (5th Cir.2005). We decline to follow this approach. Although a within-guidelines sentence demonstrates the court considered one of the § 3553(a) factors — namely, the guidelines


of both that record and the factors in section 3553(a).").

30
To sum up, appellants have the burden of demonstrating unreasonableness. A sentence that falls within the guidelines range is more likely to be reasonable than one outside the guidelines range. There are no magic words that a district judge must invoke when sentencing, but the record should demonstrate that the court considered the § 3553(a) factors and any sentencing grounds properly raised by the parties which have recognized legal merit and factual support in the record.

C.

31
In this case, the District Court imposed a sentence at the highest end of the guidelines range, 105 months. Cooper has not met her burden on appeal of proving the sentence was unreasonable.11 The court addressed the § 3553(a) factors and found "that theReform Act "continues to provide for appeals from sentencing decisions (irrespective of whether the trial judge sentences within or outside the Guidelines range)"). Nothing in Booker addresses or overrules the Court's precedent in Ruiz, which recognized the limitations effected by §§ 3742(a) and (b) on a defendant's right to appeal decisions not to depart. Ruiz, 536 U.S. at 626-28, 122 S.Ct. 2450. We follow the Courts of Appeals for the First, Sixth, Eighth, Tenth, and Eleventh Circuits in declining to review, after Booker, a district court's decision to deny departure. See United States v. Burdi, 414 F.3d 216, 220 (1st Cir.2005) (finding no jurisdiction to review a decision not to depart after Booker); United States v. Puckett, 422 F.3d 340, 345 (6th Cir.2005) (same); United States v. Frokjer,


Booker, district courts must consider the § 3553(a) factors and calculate the appropriate guidelines range, and the imposed sentence will be affirmed "as long as it is within the statutorily prescribed range ... and is reasonable") (citations omitted); United States v. Mares, 402 F.3d 511, 519-20 (5th Cir.2005) (holding sentences will be reviewed for reasonableness post-Booker, including those imposed "within a properly calculated Guideline range"); United States v. McBride, 434 F.3d 470, 476-77 (6th Cir.2006) (holding the court would "review ... a defendant's claim that his sentence is excessive based on the district court's unreasonable analysis of the section 3553(a) factors in their totality" based on "Booker's mandate"); United States v. Mykytiuk, 415 F.3d 606, 607-08 (7th Cir. 2005) (holding Booker requires "that we measure each defendant's sentencedefendant's arguments and the § 3553(a) factors at sentencing is by itself sufficient for Booker purposes. 426 F.3d 1324, 1329-30 (11th Cir.2005); see also United States v. Talley, 431 F.3d 784, 786 (11th Cir.2005).

7
 We do not address here the standard of proof for finding a separate crime under relevant law

8
 We are well aware that sentencing judges normally state and resolve sentencing issues from the bench while the sentencing proceeding is underway. As we have previously observed, "`[d]istrict judges normally deliver their decisions on sentencing from the bench, just after, and sometimes in the course of, the presentation of numerous arguments and even evidence as to the permissible range and proper sentence. These often spontaneous remarks are addressed primarily to the case at hand and are unlikely


need arises"); see also United States v. Mykytiuk, 415 F.3d 606, 607 (7th Cir.2005) ("The Sentencing Guidelines represent at this point eighteen years' worth of careful consideration of the proper sentence for federal offenses.").

11
 We note the Seventh Circuit's observation that "reasonableness is a range, not a point."United States v. Cunningham, 429 F.3d 673, 679 (7th Cir.2005). "If the judge could, without abusing his discretion, have ruled in the defendant's favor, the defendant is entitled to insist that the judge exercise discretion, though he cannot complain if the exercise goes against him." Id.

37
ALDISERT, Circuit Judge.

38
I am pleased to join in Parts I and III of the majority opinion. I am also able to join those portions of Part II.B & C in which the majority discusses how afailed to properly consider the § 3553(a) factors in conjunction with the Guidelines' recommended sentence. If she is correct, then this Court would have jurisdiction under § 3742(a)(1) because § 3553(a) mandates consideration of these factors. See Booker, 125 S.Ct. at 757.

77
In an excellent presentation, the majority has summarized how the District Court adequately considered the § 3553(a) factors in setting sentence and appropriately addressed the reasons for the sentence it pronounced. The majority states that:

78
The court addressed the § 3553(a) factors and found "that the sentence to be imposed is reasonable in light of these considerations." More importantly, the District Court appropriately addressed Cooper's argument that her sentence was excessive considering her minimal criminal history compared to those of other, similarly sentenced defendants. The court rejected this