reported in the literature possess a MIC in the same range of BC. For example, [@B1] describe keyicin, a new a bis-nitroglycosylated anthracycline, that has an action mechanism different from that of other anthracyclines. Keyicin was active against gram-positive *Bacillus subtilis* with a MIC of 7.97 mg/L and against MRSA with a MIC of 2.01 mg/L. [@B47] obtained MICs of 1.39--5.57 mg/L for two compounds from the Aurachin family that had antimicrobial activity against *S. aureus*, *Streptococcus pyogenes*, and *B. subtilis*. They obtained a MIC of 44.57 mg/L against MRSA, whereas rifampicin and ampicillin had respective MICs of 3.29 and 22.36 mg/L.

######

Evaluation of antibacterial activity of balsacone C against *Staphylococcus aureus* and the clinical isolates of MRSA and MSSA.

  **Isolate number**   **Balsacone C** Airbnb Is Accused Of Destroying Cities. This Company Says It's The Ethical Alternative.

Italy-based Fairbnb intends to invest half its profits back into the community.

ElOjoTorpe via Getty ImagesAmsterdam has seen protests about housing affordability in the city. Protestors levelled some of the blame at Airbnb saying homes are being bought specifically to be used for short term rentals on the platform.

Sito Veracruz, a one-time Airbnb host who lives in Amsterdam, believes there are clear positives that can come from short-term rentals – putting money into the pockets of local people and letting tourists experience new communities. But he thinks there is a better way.

Veracruz is one of the people behind a platform called Fairbnb, headquartered in Italy, which pitches itself as a more socially responsible version of holiday-rental platforms


and acknowledge One Love on a cellular level in this Physical Realm? We are who we are. It is what it is.

# Preface

Where do I begin... let's just say... "I MADE IT!"

It's been a journey and not an easy one. It has been scary, strengthening and eye opening. I have gone from a " _perfect_ " little life, to a highly " _dysfunctional_ " life, to a " _homeless_ " life, to a life that I only _dreamed_ I would be living. The details of the "dream" are nothing as I imagined but the comfort and bliss I found has made the journey all worth it.

There are a few things I have always disliked/hated: Chickens and eggplant; riding a city bus; missing out on family functions; being awayin knowing their father they know themselves. I also cannot imagine the reuniting with our eldest son in 2006 if we weren't together. It was such an emotional roller coaster ride with tons of drama as it was; I cannot imagine riding that ride with Steve and I not being together. I have heard about those other reunions where the mother of loss and father of loss are played against one another at such a higher degree than what we were dealing with and the degree of drama that we were already living was so much... I could not imagine Steve and I not having each other to make sense out of the madness.

After the reunion with our first born son, we moved back to Utah from Texas


years.

The next time I started medicating with weed again was in 2004 when my husband of 16 years got caught cheatin' and was expecting a child with another... she was ten years younger than me. Both my father and my sister who were both married in the Temple, came up to me separately suggesting that I start smoking some weed because I was having a hard time processing in my head _WTF_. I was concerned about me not being a good mom so I tested out _half_ of a little blue "legal" pill ( _valium or something)_ that many of the "Temple worthy" Mormons are prescribed and had the worst trip I've ever had. It was like being drunk and stoned at the same time... _"I can't bea good mom on this shit"_ ... I have been smoking the herb ever since.

Desert Rocks

By Dallen

June 2011

Watching my Dad use and abuse alcohol and pills has saddened me since the age of 6.

To cope with the hurt of my father's drowning of sorrows, the affairs, and Kai coming back into our lives, (who was also a disappointment to me with such imbalanced Chakras) my mother started smoking Marijuana.

My father was abusing legal pain killers and alcohol more than ever around the time when my brother moved in. Kai would go to bars with my dad. He was also on prescribed medication with me following suit; Which flared the Tourettes more than ever, bringing rage into it. I decided at 9 years old, "I'm not doing that chemical


was, he just knew. Dallen had insisted we catch Steve doing whatever this " _black_ " was and **October** 2011, we did... _black_ is HEROIN.

It was **October** 2011 when the shit really hit the fan. Kai had returned home from his mission, married and moved away. The adoptive parents' behavior had gotten so possessive over that boy of ours they adopted... seriously, the mom had called the police on me because Kai was storing his things at our home while he was away for the summer.

I can't say for sure what it was that pushed Steve to go from church goer to Heroin user... but he had apologized at one time in the middle of this madness that it was too much for him to be addressing issuesher new fear... I am going to be excommunicated from the Mormon Church!!!

Well, you know what? I have a better relationship with Jesus and know that I will not be damned if the church kicks me out for bringing awareness, speaking out, teaching others how to love unconditionally, supporting unwed mothers in need to keep their children and fighting to bring father's rights along with women rights to full attention, accepting others, loving everyone as a whole, not judging who is better than whom, as in who would be a better mother and father for the child... THE mother and father ARE the mother and father of that child and we as a whole, need to love one another and mentor any person in need, especially a person


Kai in our family and accept it for what it is because we cannot change the past. We needed to clear the energy, so we could have a healthy relationship in the future since our relationship has been traumatized by adoption... my "choice" as a 16 year old mother, I know... I will live with that "choice" for the rest of my life.

It has been a huge blessing to have my son Dallen on this journey of healing with me. He teaches me as much as I teach him. It's crazy, but he will process an emotion, be upset, react, scream and rage... and then, shortly thereafter, I am processing that same emotion and what he just processed. It was so great to have Dallen to look tothe crow bar over his throat. I once again inform Steve that I am going to count to three and then apply pressure, he just needs to release his grip on the keys and it's over... "123"... kneeling at my husband's head I apply full force down blocking his airwave... it didn't take long for him to lose grip and Dallen to get keys.

Folks... I am one that is known to not involve cops so my daughter has learned that when I say call the cops, I mean... really... call the cops. I have resorted to their assistance twice in my life...

Simultaneously the cops rolled in just as Steve lost his grip and we all jumped up just in time for the cops to take over and off


with her for a week figuring out our flights and where we were going to stay. Frantically I searched craigslist looking for places to stay. No one would take me, my credit sucked, I had no job, I had 3 teenagerish aged boys, and I'm new to the island... Finally, it took a Lee McClusky that for some reason agreed to rent to me... if I could deposit the money in his account by such and such day, it is mine. I deposited the money and we agreed to meet the day of our landing... go straight to our new home from the airport.

### Time for Take Off

July 21, 2012

It was a good thing Chance came with us. Dallen, Elden and I were so ADD, moseying on ourmother, with me saying, "He has a Bozo the clown like quality".

Dallen says "No, he is like the Yang of Beetlejuice, you know, Beetlejuice being the dark bad, the Yin of it and Lee is like the good and the light of it but he looks like a nice Beetlejuice".

After I get off the phone with my mother, we notice that lovely man Lee, on the porch under the windows hearing everything we said... Good thing we loved the guy!!!

But I put on that good ole oblivious act that I do so well, and sing out oh so sweetly, "Lee, there you are! What are you doing today? You been to church? Whatcha doing?" and I join him for a morning chit chat.

Come to find out, this dear


of that... Come to find out... his wife works at Family Services here in Maui and I had just applied for a job there for a position to help single pregnant mothers KEEP their children.

And that leads me to Jeff & Darrin... which I must inform many of you that are not Stone family members... Steve, my past husband of 23 years has a brother, named Jeff. ... Steve, Jeff & Darrin, their childhood friend that they had pretty much been raised with as a brother, were living on their own when I met Steve.

Well, I was sitting outside of Welfare Services to see what I qualify to receive... I barely pull out a book to read and this character my age with a Mohawk, (Jeff) says, "Youusing it as an excuse to invite me to Mr. Longhi's Funeral Party.

Mr. Longhi is a celebrity like fellow that owns restaurants on the island and this Tim fellow had asked me to attend this celebration with him. When I declined and said, "I don't go anywhere without my boys".

He said, "Well, bring them along". Still politely declining, he then says, "Owen Wilson most likely will be there." Well, that didn't change my mind and when I never showed up for the party, he showed up this morning, asking what happened, informing me that I missed out on a great time..."Owen didn't show up but Mick Fleetwood gave everyone a show on the drums".

Wow, I cannot wait to be an established local; I have already barely missed that


to vacation.

Chance was the first to get a job. He was an excellent example to Elden and I. Chance would go out by bus for interviews all over. Chance had even checked out Lahaina for jobs and had arrived back home to let us know, that is where he sees us working and we should go check it out.

Chance had accepted a job at Costco and had a few weeks until he had to attend training. He flew his girlfriend out and that was the beginning to the end of Chance being here.

To sum it up in a nutshell, I felt Chance lost the focus of " _We are in this together. We are one._ " Instead of the four of us hanging and getting to know ourI will always be here for you, even though I am leaving your brother, you are always welcomed in my house, even in Maui."

Around the same time I was making plans for separation from Steve, Pati had decided to go try to live by babies' daddy to help her parent his three children. After I had been in Maui for a few weeks, she called me in tears, asking if my invitation was sincere. Babies' daddy has some addictions. ... So sad, it happens to the best of em... the intelligence of that man...

Pati sold her car to get the plane tickets she needed for her and the kids... We were running out of our money but Elden got a job at Ululani's Hawaiian Shave Ice (notorious for


tiny part of your love. but no, you kill him with your words, as there are in thy knives that cut me, burn me, kill me. and I'm dead and you're not to mourn for me.

Learn if you do not understand women. Spanish is a language of love, maybe one day I hear.

First of all, everything is a reflection... a mirroring of what is wrong with our own behavior...

You say I... "Never accept you as a child no matter how you behave with me, I always reject you and your love," ... Well, yes now that you complain about it, yes that is how I feel your behavior has been... Crazy how when I start acting like you have role modeled our relation to be, you get allwas seriously in shock, thinking, "No, my mother has been a landlady for many years and this would never fly... no judge will execute on not working with two single mothers and $123.45, kicking them out on the street."

Well, Lee McClusky must know people in high places because, he did just that.

We had found a place in Lahaina, but it would not be available until October 24th. We had tried to work it out with the landlord but he wanted us out ASAP. (he had other tenants in, the very next day.) Lee McClusky was able to get an execution and force us to leave in 24 hours and then the cops would come.

Pati took charge, (her bennies kicked in, they had found her paper work by now).


I had the same belief... but when shit hits the fan in a huge way, I for one needed further knowledge of WTF why me when I was being such a good little daughter of God serving in his church to the depths that I was before 2005. Glad to hear you are so content and happy with your life.

I have a simple sweet life because I choose to smile at everything the Lord has dealt me your attitude of "why me" is your failing the test that was given you. Just because you are serving in the church does not make you exempt from trials and hardships, rather it strengthens us to be able to bear the burdens joyfully, and it fills us with love that weme til ninth grade when I broke away, found myself, my mission and the mentors to teach me the wisdom I need. I don't boohoo about what life's done to me, I rejoice about where it's gotten me and what I've learned from it. It's gotten me to where I am now and I love where I am. I'm so in the present and high off life and Source. So keep loving, relating to, and healing, talk to you when you can understand and love unconditionally...

Sounds good, we never met, deal?

### Letter from my Mother

January 28, 2013

Dear Keri, Aloha from the mainland! I haven't been able to reach you by phone so I thought I would write the old fashioned way. We get so used to instant connection


we took a break from talking to each other... well, you could say, I was taking a break from talking... that cold as ice behavior tends to kick in when I don't feel safe in a relationship.

I remember Pati had called me on a Monday morning asking if I had heard from Linda, their mother; I hadn't. Pati then proceeded to tell me that she gave her mother until today to inform me what is up with Steve. For some reason their mother was wanting to keep it a secret from me. I was already wondering why Steve wasn't answering my calls or calling me back.

I guess Steve had broken in a few houses in the night with a loaded gun like a crazed maniac strung out onthe mix completes it, creating total balance for the elemental signs; earth, air, water, fire)_

This got me thinking... what does it mean that Kai's wife is born on June 27th, delivering my first born granddaughter on her birthday June 27th?... If you read into it via Numerologically, 26 is 8 _(that magical infinite number that is strongly in my space)._ According to Doreen Virtue's Angel Number 101 book _the number 8 signifies abundance and prosperity. The endless loops in this number signify an infinite flow of money, time, ideas, or whatever else you require (especially for your life purpose)_... 27 is 9 which has a meaning of completion. Doreen's book definition... _9- Get to work, Lightworker-now! The number 9 means that you've completed all of the prerequisites to


life was all for no reason, makes it pretty hard to have any reason to move forward... because where in the hell is life going to lead me? And how am I going to live my " _perfect little life_ " that I have always dreamed about? If my path/my blueprint obviously doesn't have the " _perfect little family_ " program _(that I have been taught is everyone's goal)_ as the end of my journey in this life, then what is the destination?

I was getting impatient for the destination and not enjoying the journey. It has been real scary charting into unknown waters with only my 15 year old son, and my nephews... in a matter of months, I left my husband, my house, my daughter, my eldestson.

### Kirah Hates it Here

March 2013

I talked to my mother today...we finally figured it out... Kirah is going to go back to Utah and live with grandma. Kirah hates Hawaii so bad, she was determined to live with whoever would receive her... My mother always jumps in to rescue and she had great skills from working as a state assistance specialists... she knows how to rehabilitate and Kirah needs some rehabilitating.

It was quite challenging to have Kirah in the mix. She hadn't gone through the first half of our journey, surviving as one... and to tell you the truth, I don't think she could have survived it. We needed all the positive thinking we could muster to climb the upward curve to get back to a desirable place


children has needed to be an only child, each one of them requires a lot of individual attention._ " With that my mother volunteered for the job, paying for Kirah to fly back home to Utah so Kirah could be the apple in grandma and grandpa's eye, getting oodles of attention along with guided direction and scheduled counseling sessions and a program my mother developed called ESTEEM.

Letters with Steve

4-9-13

Hey guys, I got your letters on Thursday then I got my letter back last night that I mailed a month ago. Crazy slow mail.

Everything is good here. I'm in a program called CATS that is like rehab in jail, it is good. It keeps me busy so time flies. I will be out some time mid July. The firstanymore. I am so glad Pat (healer in Mapleton) warned me that Kirah was not part of the Hawaii journey... and boy is she not. She hates everything about it here. Which again, I can understand... the poor dear lost her family, her dad, her house, her room, her belongings, her state AND her friends... all in such a short time. It will be good for her to be there by her daddy.

Plus, remember what I had been told... children are Karmic Debt to help refine and clear our energy... Kai and Kirah are your Karmic Debt... because of the mission I am to do, I was gifted Dallen to ground me and get me where I need to be.

Dallen loves and adores you. He cannot wait for


tell everyone that Kirah is a fine tuner; she amplifies the situation and is quick to point out faults in mirroring huge projections of others LOUDLY. Kirah came into the space and rocked our world, shook her aunt Pati and Dallen up and left on her way just as sweetly as she had arrived.

This surrender I speak of ... Before, I still was steering my life making choices trying to push in the direction I wanted to be with my mind, trying to figure out what to do next to speed up this process of getting to the favorite part of the ride in "My Life"... I finally have washed away the feeling of rushing around through it trying to force it to happen. I have mastered acceptingWe play a lot of cards and we both have times that we like quiet so we can read. Oh and we both like to go back to sleep after breakfast until lunch hehe I know lazy boy. I read about 400 pages a day of fictional novels then I am studying math and social studies and I have a bunch of computer books, my scriptures, some self-help stuff my mom sent me and my LDS addiction recovery book, so lots of reading, studying and contemplating changes to make in my past behavior, my head seems a lot calmer. I think it makes my handwriting neater.

I'm not too good at meditating but I am working on it and seem to be getting better. Are you taking care of


responsible and choose carefully the things you choose to put into their minds. Don't teach them at a young age that weed is the path for them. Let them decide for themselves. Remember that society still considers it illegal and there are health related side effects from any kind of smoke.

Are you being smart with your money? Have you gotten yourself the things that you need to do to do glass blowing? I hope you don't take my advice as lecturing because that is not my intent. I just want you to be the most amazing man that you can be.

I have my sentencing on the 16th which is 2 weeks from today. I hope I get out that day and go down to the rehab center inof funny I think.

How is book #4 coming? I am excited to read it.

I have been craving your potato salad, baked beans, potato hash and just your cooking in general. As well as a lot of other things, but I won't go there.

So I am getting a journal and I am going to write down all of my memories and stories from my life. I wrote down all of the states that I have been in and it is 33. A good chunk of them you have been to with me. I am excited to do a lot of traveling when I get out of here. I want to go to Ireland, London, Paris, all over Italy and Venice. I definitely want to spend more time in New


author of "Work and the Glory" about an arms dealer that hires a LDS man. It was good. I am reading "The Lost Symbol" by Dan Brown. It is about symbology, freemasonry and Noetic science, which has to do with the law of attraction, ancient and sacred geometry etc. they talk about how human thoughts have mass and can be weighed and analyzed. It is very intriguing. I am reading Book of Mormon for the 2nd time; D&C for the first time. I didn't realize how much clarification of revelation heaven and the afterlife is clarified in the D&C. it is really informative. I am going to start the Bible next week. I think I will read the New Testament first then the old. Then I have avisit! It was so good to have a girlfriend to chat at that has known me for the most of my life. We had a day of it ... we checked out the horses nearby and had an interesting interaction with a horse with some kind of allergy or maybe my fairies got to tickling his nose....

_Horse_ _~Travel, Power and Freedom... they are symbols that can express the magical side of humans. It has been a symbol of desires-especially sexual. The taming of a stallion would then be the taming of sexuality and dangerous emotions. ... are you feeling constricted? Do you need to move on or allow others to move on? Is it time to assert your freedom and your power in new areas? Are you doing


I was 226 into it when this period's library came last Friday. Today is Monday. So I am still working out 6 days a week during the day... I do abs at night after lights out. I am getting too much stamina and strength though for cell workouts. My chest workouts now take over 2 hours... my elbows have been sore the last week or two from so many pushups. Love dad

Keri,

How are you? I'm doing well. I have my sentencing in 2 weeks so I am just trying to stay positive for that. Hopefully I get out that day and go down to a rehab in Payson called STEPS. Regardless of what happens, I will know the end game so I can settle in and finalize thisyou and only you and only you

Like It or Not ...You can call me a sinner, you can call me a saint. Celebrate me for who I am dislike me for what I ain't. Put me on a pedestal or drag me down in the dirt. Sticks and stones will break my bones but your names will never hurt. I'll be the garden, you be the snake. All of my fruit is yours to take better the devil that you know, your love for me will grow because, this is who I am, you can like it or not, you can love me or leave me cus I'm never gonna stop...

WOW!!! Right? I am so living the last of the CD

I want to know what is next!

Girl Gone


are only charges like drugs, DUIs, fraud and stuff like that I guess it is rare that I could come here with my gun charge, but at the prison all of the counselors said I was so mellow and nice that I got to come here. So instead of being in our cell 23 hours a day, we are only in our cell from 10pm to 6:30am so that is super nice. Also, the TV is on from 6:30am to 10pm, so I get to watch sports. In the section that I am in, there are 28 people. I think like 20-22 of them are between 19 & 26. So a lot of kids like Jade and his friends, so that is ok. Not a lot of swearing,awakening the inner depths. It's time to show magnificence and power of your creativity, do not hold back._

Anna is a great friend I have that works the booth opposite of when I work the booth. The problem is, we never see each other at work, so we are always making dates with one another. For one of our hook-ups, we went to the beach by her house to discuss our dreams and desires. We had the most interesting experience with this big sea gull looking bird. The bird perched itself right in front of us on a rock, almost as if it were enjoying our conversation. It sat and "listened in" for a long while, (Anna _and I get pretty chatty_ ). Anyway, this bird flew off just


just take off...

Well the boyz were being escorted slowly by the other rangers... for some reason Dallen didn't have shoes and did the hike barefoot which slowed him down and God bless Jade and Elden who stayed by his side while Kai and I took off... when we flipped the car around to have them jump in...the rangers had already called back up with two vehicles pulling up on the scene with their lights rolling. After playing blonde, and having them believe us that we are truly in a hurry to get Kai off to the airport, and after they ran my name; seeing the whole "I got arrested on Labor Day"... the rangers got a little escalated about Marijuana...developing fear in their space because I am listedwith their choice of drugs... Pills that Kill.

So that was the Christmas season... except for, I forgot to tell you... part of the reason for me calling out the plans to forget about Kai for his birthday and Christmas was because your sister Karen had called Kai and informed him that the Stones were getting together the day after Christmas and asked if he was going to be there... I witnessed Kai acting all cheery, as he does with everyone, telling her, "ya ya we will definitely be there." Then as soon as he hung up with her, he says, "ya right, not going to that." Well, I immediately asked Kirah and Dallen if they wanted to go to the Stone party because if they want to go,


Special meeting for special assessments

By David Hotle | Apr 12, 2013

With five years having passed since the City of Washington used a special assessment to help pay for a street reconstruction project, city administrator Brent Hinson said that he feels the council needs to learn more about the practice. He also said the council needs to develop specific guidelines for the use of special assessments. Calling the program being discussed by the council a “kinder and gentler” version of past special assessments, he said that a work session would be conducted at 5 p.m. Wednesday in the former Washington Public Library on the topic. The session will be held prior to the regular meeting at 6 p.m. Hinson said the adoption of an ordinance governing special assessments wouldtype and *P2X*~4~*−/−* mice. Monomeric P2X~1~ can be seen highly concentrated in the pulldown fraction at 50 kDa. Little P2X~1~ appears in FT. (**B**) P2X~4~ antibody detects P2X~4~ as a band at 70 kDa in wild type, but is completely absent in *P2X*~4~*−/−* mice. The antibody shows minor cross-reactivity to possibly P2X~1~. Note, there is no evidence of the 70 kDa band in the IP lane. (**C**) An antibody to 5′-nucleotidase (Nt5e) demonstrates that pulldown with anti-P2X~1~ is 'clean' with no non-specific protein binding evident in the IP lanes.

We performed immunoprecipitation with the anti-P2X~1~ antibody to examine whether P2X~4~ protein could be co-immunoprecipitated along with P2X~1~ (Fig. [2B](#Fig2){ref-type="fig"}). The anti-P2X~4~ antibody has also been validated previously for its specificity, using knockout mice^[@CR29]^. P2X~4~ protein (\~70 kD) was only detected in the non-bound FT


Our co-IP data did not support a P2X~1~/P2X~4~ heteromer in the bladder. Further support for this conclusion was provided by immunofluorescent staining and confocal imaging, which indicated that P2X~4~ is expressed in the bladder wall but is not in smooth muscle itself (Fig. [4](#Fig4){ref-type="fig"}). The left panels (top) show discrete punctate P2X~4~ staining in wild type bladder (white arrowheads) and these appear to be true P2X~4~ positive cells because that unique staining pattern is absent in *P2X*~4~*−/−* bladders (left middle panel). There is however non-specific labelling of thin fibrous structures in the P2X4 knockout (white arrows).Figure 4P2X~4~ is expressed in bladder wall but not in BSM. Cryosections of mouse (wild type and *P2X*~4~*−/−*) bladders were labelled with antibodies to P2X~4~ (green), P2X~1~ (green), ENTPD2 (red), and Topro-3 to labeland bladder compliance (Fig. [6C](#Fig6){ref-type="fig"}), thus confirming that *P2X*~4~*−/−* mice have undetectable changes of voiding function. Likewise, myography studies indicate that urothelium denuded BSM strips from *P2X*~4~*−/−* mice have normal contractility in response to EFS, including both the muscarinic and atropine resistant force components (Fig. [7](#Fig7){ref-type="fig"}). In summary, these data suggest that P2X~4~ does not contribute to physiological voiding function in mice.Figure 6Cystometrograms showing intrabladder pressure throughout multiple filling/emptying cycles indicate that *P2X*~4~*−/−* mice have normal voiding interval, pressure, and bladder compliance; (**A**) CMG trace for a wild type mouse; (**B**) CMG trace for a *P2X*~4~*−/−* mouse; (**C**) Quantitation of cystometric parameters showing no significant differences between wild type and *P2X*~4~*−/−* mice.Figure 7Myography indicates that BSM from *P2X*~4~*−/−* mice have normal contractility in response to electrical field stimulated neurotransmitter release.


P2X~1~ and P2X~4~ do not form heteromers in mouse bladder at all (Figs [2](#Fig2){ref-type="fig"} and [3](#Fig3){ref-type="fig"}), and furthermore, our IF and imaging data indicate that P2X~4~ is not present in BSM cells, but in a small unknown cellular structure that is dispersed within muscle bundles, and in particular associated with circular structures that might be vasculature (Fig. [4](#Fig4){ref-type="fig"}). We do not know the identity of this P2X~4~ positive structure, but it could relate to neuronal structures, which are thought to have interactions with ENTPD2 positive interstitial cells located among muscle bundles^[@CR52]^. It is possible that P2X~1~ forms homomeric receptors in BSM as suggested by P2X~1~ null mice, in which the BSM loses the majority of its purinergic force^[@CR14]^. However, the potential existence of other P2X receptors, the non-typical P2X~1~ pharmacologicalOnly male or female mice were used in some experiments (see below). If not specified, both male and female mice were used. Mice were euthanized by 100% CO~2~ inhalation from a gas cylinder into a plexiglass chamber.

Myography {#Sec11}
---------

Bladders from male wild type and *P2X*~4~*−/−* mice were pinned on a small Sylgard block and bladder mucosa was dissected away carefully. BSM strips were then cut longitudinally (2--3 mm wide and 5--7 mm long) and mounted in an SI-MB4 tissue bath system (World Precision Instruments, FL, USA). Force sensors were connected to a TBM 4 M transbridge and the signal amplified by Powerlab and monitored through Chart software. Contraction force was monitored dynamically with a sampling rate of 2000/s. BSM strips were gently pre-stretched to get optimized force and equilibrated for at least


was implanted through the dome of the bladder, which was secured in place with an 8--0 silk surgical suture. The mouse was placed into a restrainer and the catheter was connected to a pressure transducer (and syringe pump by side arm) coupled to data acquisition devices (WPI Transbridge \[Sarasota, FL\] and AD Instruments Powerlab 4/35 \[Colorado Springs CO\]) and computerized recording system (AD Instruments LabChart software).

Statistical analyses {#Sec18}
--------------------

Data are presented as mean ± standard deviation (SD). Data were analysed using Student's *t*-test for paired groups or one-way analysis of variance (ANOVA) for comparison among groups. Bonferroni's multiple comparison post-hoc tests were used where necessary and P \< 0.05 was considered to be significant.

Electronic supplementary material
=================================

 {#Sec19}

supplemental information

**Electronic supplementary material**

**Supplementary information** accompanies this paper at 10.1038/s41598-018-20216-4.

**Publisher\'s note:** Springer Nature remains neutralto recording and reproducing is recorded with cutting a land and a groove at each specific period of time.
FIG. 19 is a fragmentary plan view of a disk partially enlarging a microscopic construction 20, that is, a physical format construction of the land-groove recording method disk. In FIG. 19, the drawing shows an external appearance of the construction when the disk is not recorded and grooves 21a through 21c, hereinafter represented by the groove 21, are formed in parallel to each other. Lands 22a and 22b, hereinafter represented by the land 22, are allocated in between the grooves. An information is recorded on both the groove 21 and the land 22 when recording. A plurality of address pits 23a through 23n, which is necessary to recording and reproducing,


where Nader picked up 3.1% leaving Bush with only 15.5%. Some interesting statistics:

As was evident in 2000, Bush carries many more of the rural, low-population townships, while Kerry scores solidly in the cities. To wit, in Kerry’s top 10 are four of the New York City Boroughs, the cities of Buffalo and Albany, as well as the City of Mount Vernon (Westchester county). These seven municipalities cast almost 2.5 million votes for President and rack up a margin of 1,354,849 votes for Kerry (this is, remarkably, about 3,000 votes more than Kerry’s state-wide margin of 1,351,713). The remaining three in the top 10 are the City of Ithaca, the surrounding the Town of Ithaca, and the relatively small Town of Woodstock (of 1960s fame in Ulster county) withMurphy Oil CEO: Now is the time to invest in deepwater

The timing is ripe for oil companies to invest in new deepwater exploration and production because it’s a buy-low opportunity when prime onshore shale acreage is selling at a premium, said Murphy Oil CEO Roger Jenkins.

After taking an extended break from major offshore exploration to grow in Texas shale, the historically offshore-centric energy company is again looking to grow in the deep waters around the world, Jenkins said Tuesday at the Offshore Technology Conference in Houston.

“Now’s the time to explore again,” Jenkins said, while increasing production in low-cost offshore opportunities like shallow waters and areas with existing infrastructure.

“We’re at a very low point in the cycle – it’s been going on for 30 months – and now is


Produced by deaurider, David E. Brown and the Online
Distributed Proofreading Team at http://www.pgdp.net (This
file was produced from images generously made available
by The Internet Archive)

The Law's Lumber Room

_Of this Edition 600 copies have been printed for England and America._

  The

  Law's Lumber Room

  By

  Francis Watt

  London

  John Lane, The Bodley Head, Vigo St.
  Chicago: A. C. McClurg & Co.

  MDCCCXCV

  TO
  WILLIAM ERNEST HENLEY
  FLOTSAM AND JETSAM
  FROM HIS OLD JOURNAL

PREFATORY

To the Lumber Room you drag furniture no longer fit for daily use,
and there it lies, old fashioned, cumbrous, covered year by year with
fresh depths of dust. Is it fanciful to apply this image to the Law?
Has not that its Lumber Room of repealed Statutes, discardedwas only three words--_Miserere mei, Deus_: "Have mercy on me, O
God." It seems strange that it was ever recorded of anyone that he
did not read, and was therefore condemned to be hanged; for surely
it were easy to get these words by heart and to repeat them at the
proper time? This must have been done in many cases, and yet sometimes
criminals were so densely ignorant and stupid, or it might be merely
bewildered, that they failed; then the wretch paid the penalty of his
life. "_Suspendatur_," wrote the scribe against his name, and off he
was hauled. The endless repetition of this word proved too much for
official patience, and with brutal brevity the inscription finally
appears, "Sus." or "S."

And now the Neck-verse was free to everyone were he or were he not in
holy


posts, and a sharp stone under your
back."

There is but one rational way to discuss an institution of this sort.
Let us trace out its history, for thus only can we explain how it
came to have an existence at all. For the prisoner himself there was
usually a very strong reason why _he_ should stand mute. If he were
convicted of felony his goods were forfeited; while in case of capital
felony, the result of attainder was corruption of blood so that he
could neither inherit nor transmit landed property. Often he must
have known that conviction was certain. Had he fondness enough for
his heirs--children or other--to make him choose this hideous torture
instead of milder methods whereby the law despatched the ordinary
convict from this world? Well, very many underwent the punishment.
Between 1609-1618 the number wasdeparted
in contempt of the Court." Evidently, or so it seemed, he had no answer
to make. Then B's claim was allowed; C was to have of the lands of A
a quantity equal to what he had nominally lost; whilst A, in his turn,
was to have the same remedy against Jacob, who, having no means at all,
cheerfully accepted much paper responsibility. Then a writ was issued
to the sheriff of the county wherein the lands were situate, directing
him to give possession to B, whose title was constituted by a record of
all the aforesaid transactions.

As the centuries went by the proceedings became ever less substantial,
the action was always commenced by the issue of a writ in the usual
way, but most of the other steps were only taken on paper. Sir
Frederick Pollock says,


no force on the high
seas or in tidal rivers: because, said some, "there were so many
deaths at sea." "Nay," said others, "how forfeit the ocean?" "But at
least," it was replied, "one could take the ship"----but here again
speculation must stop. Although deodands first went to the Crown, and
were properly applied to pious or charitable uses, yet they were often
granted to lords of manors: so often, indeed, that one of the few
references to them in English literature--a couplet in Samuel Butler's
_Hudibras_--treats this as the general rule.

  "For love should, like a deodand,
  Still fall to the owner of the land."

This owner was not seldom exacting, and his claim was met in
characteristic English fashion. The coroner's jury returned the
value of the deodand at next to nothing, _e.g._, "a horse,a sore grievance
of late--he was to lose his rights. The governor was empowered to
hold courts for debt and minor offences within his bounds. And so "the
sanctuary person abjured," as the Tudor lawyers phrased him, spent the
last days of his evil life. I need not dwell on minor tinkerings of the
system under Henry's children. In 1623 the Statute 21 James I., c. 28,
s. 7 made a legal end of the right of sanctuary.

The last of our story is not yet. Certain places still assumed the
right of giving shelter against civil process. When the bailiffs
invaded the liberty, the whole population forthwith set on, and
pommelled them so lustily that they were fortunate if they escaped
sound in limb. The precincts of Whitefriars and the Savoy were
the worst places in London. The first,


I Am Looking To Trade Off My Burb For A Daily For My Wife.nneeds To Have Enough Room For A Family Of Five.nyork Engine Driven Compn10 Switch Setupn1/2 Valves And Lines Twelve Gallon Air Tanknfuel Cell...For Sale in: , Indianapolis, IN, , USAtransistor would behave as an OR gate. Below that thickness, and it would perform AND operations.

Light and memory

At this point, the paper switched into something like "but wait, there's more!" One demonstration was that it's possible to switch an AND device into something that performs OR operations using the right wavelength of light. The gist of this is that the input gates work by exciting electrons within MoS 2 into a state where they contribute to carrying current. In a thin layer of MoS 2 , both inputs have to be pushing electrons into the conduction band to get any current flowing. This gives us an AND function.

But light of the appropriate wavelength can also push electrons into the conduction band. As a result, light lowers the requirement


the IRS has not budged on its plan to limit the
capacity of plants to which it issues rulings to absurdly low numbers.  The
industry has complained to the Treasury, and there have been discussions at
senior levels of Treasury and the IRS, but no reports back on where these
internal talks are headed.

	Detroit Edison has a meeting with the IRS on its ruling request next
Tuesday.  The IRS has said it will limit capacity at the DTE facility to
198,000 tons a year.

	I assume you saw the article last Thursday in the Wall Street
Journal about syncoal projects.  It was on the front page.  As far as I can
tell, all proposed sales of syncoal plants in the market are on hold.  This
is a consequence of the Wall Street JournalQ:

How to enable stacktrace react-native run-android command?

I'm running a react native project via the react-native run-android. But during the build it fails stating that :react-native-device-info:processReleaseResources FAILED. Which doesn't give much info, so I tried running with react-native run-android --stacktrace as suggested but that isn't a recognized command.
How can you enable stacktrace / verbose logging with react-native run-android command?
This is the detail of the error which is too short to figure out at build:
:react-native-device-info:processReleaseResources FAILED

FAILURE: Build failed with an exception.

* What went wrong:
Execution failed for task ':react-native-device-info:processReleaseResources'.
> com.android.ide.common.process.ProcessException: org.gradle.process.internal.ExecException: Process 'command 'C:\Users\Brian\AppData\Local\Android\sdk\build-tools\23.0.1\aapt.exe'' finished with non-zero exit value 1

* Try:
Run with --stacktrace option to get the stack trace. Run with --info or --debug option to get more log output.

BUILD FAILED

Total time: -12.542 secs

Package.json for reference:
{
  "name": "StarterKit",
  "version":


image. On the other hand, when printing binary images, like monochrome characters or line-drawings, the conventional printer supplies a group of drive waveforms with improved degree of resolution to obtain sharp image, in short, it supplies drive waveforms having higher frequency than in the case of color images, so as to upgrade resolution.
However, in the ink jet printer, in which the monochrome printing and the color printing share the use of the conventional drive waveform generation unit 220, if the printer must print the document 230 as shown in FIG. 2, in which the color photo 232 is inserted in the monochrome text 234, the printer cannot print the monochrome text 234 and the color photo 232 simultaneously, by performing only a single head scanning. Therefore, the printermode to high-resolution mode, even if color image including a full-color picture, etc., and monochrome image including line-drawing, etc. are intermingled. In the multivalued intensity mode of the control unit, the amount of ink particles of the color head is variable for each nozzle. The high resolution mode of the control unit can employ any one form of the followings for example.
(1) the resolution in the horizontal scanning direction of the monochrome head is integer times the resolution of the color head;
(2) the ink injection cycle of the monochrome head is integer times the ink injection cycle of the color head;
(3) a multiple of the ink injection cycle of the monochrome head relative to the ink injection cycle of the color head is equal to a multiple of


of a group of color drive waveforms generated by the color drive waveform generation unit is equal to a basic drive frequency of a group of monochrome drive waveforms generated by the monochrome drive waveform generation unit. In this case, at least one intensity waveform of the group of the monochrome drive waveforms is a drive waveform that allows ink particles to be injected twice or more during a single injection cycle of the group of the color drive waveforms. The color data supplied to the color head drive unit, and the monochrome data supplied to the monochrome head drive unit are a set of pixel data containing a plurality of bits, and the bit data of color pixels contains information representing ink particle diameters by the colora variety of goods to buy and even a section where different stalls represented different countries (the United States was represented by Jack Daniel’s and other ridiculous paraphernalia), that it kept us entertained just looking at many of these stalls. Perhaps I will return to these markets in the future, when I am not already bogged down by a year abroad in Russia, and actually buy something representative of these markets or Christmas. It won’t be the Jack Daniel’s though.


our landscape. In fact, coyotes have expanded their range two to threefold since the 1850s, largely in response to human changes to the environment and the eradication of wolves.

Coyotes have adapted to living close to people and now inhabit even the most densely populated metropolitan cities from Boston to San Francisco, Austin, and Seattle. Estimates are that 2,000 coyotes are on self-appointed “rat patrol” in the Chicago metropolitan area.

At least 19 subspecies of coyote roam North and Central America, from California to Newfoundland and Alaska to Panama, occupying a broad range of habitats. Coyotes play an important ecological role helping to maintain healthy ecosystems and species diversity. As the top carnivore in some ecosystems, coyotes help regulate the number of mesocarnivores (such as skunks, raccoons, and foxes) whichhimself making dinner by trying to pick something straight off the stove without potholders. Lois turns to him and says “Clark–hot!”

Jin is probably still in the “high” of having come back and her brain hasn’t quite kicked back into gear.

I think it’s kinda both.
She’s like, “Hmm… I wonder if…” and in her head thinking, “Omigosh, it could really WORK this time!! EEEEE!! XD”

Yeah, after living as long as she has, going though all that suffering, and wishing you could die for most of that time… I’m not surprised she’s not the least bit solemn when it comes to an act like this.
She’s like, “Alright!! Let’s do this thing already!!”

You know, I think you have a point. After all, didn’t she tell Alan that she wanted to grow old


keep the weapon pointed down-range for a minimum of 10 seconds before trying to reprime or otherwise deal with the misfire.

Fairportfan- I’ve heard that they actually did fire the weapons for some of the work. Remember special effects were in the very beginning of development. The man who played the indian/english halfbreed was a noted black powder marksman in the late 60’s I’ve been told.

Well, at least one company made a twelve-shot 36-caliber revolver (more or less what we’d call a .38 today – the actual diameter of a “.38” round is .357–.358 inches (9.0678 mm); 9mm, .38 and .357 are the same diameter round, though they vary widely in bullet weight and power…

The best flintlocks were so fast and well made you *could* fire them upside down,side again.

Those are good points. The universe only rewards survivors, however. If they make it to the top, it even rewards them with a glimpse of it’s inner workings. Not to mention their inner workings.

Yes, she may be in a “use it or lose it” mentality, taking advantage of her seeming mortality right away just to be sure.

If she were real, now would be the time to make her realize there is something she has never experienced first hand, despite being over 80K years old. Being a wife and mother(adoption) and growing old (maybe) with someone you love deeply. At the least, not having to go on for long after his death, assuming her new lifespan is less than 100 years.

Jin does look kinda cute being a bit


Day, Oh!.

We should note that “fix” is a very poor choice of words here – no reflection on Pablo, because it’s used this way all over the English-speaking world. We use “fix” to indicate “repair,” but in a purer sense, it means “to make static.” Think of fixative in pastel drawings; think of fixing a butterfly to a board with a pin; think of getting a fix on your location. The only way a living being – golem, human being, animal, whatever – can be fixed is to kill it. Jin seems intent on fixing herself, in a completely different way than May had in mind. For every suicide, the fix is two-fold – to repair everything that’s wrong with their lives, and to render themselves non-living, evenQ:

Packaging Succeeded but Publishing Failed?

I am trying to publish a very large raster data set, ~330GB. I get the general error: "Packaging succeeded but publishing failed"
The geoprocessing results say to check the server logs.
The server logs provide general error messages:

Failed to construct instance of service
'TestBrandon/ImgTest_321.MapServer'. Service startup timeout.
Core server call to create service failed (/admin/createService).
Failed to create the service.: ERROR: Service failed to start,
Internal server error.
Error executing tool. PublishServiceDefinition Job ID:
j360531ad8cd940a490f8f7ee2085dc49 : ERROR 001369: Failed to create
the service. Failed to execute (Publish Service Definition).
The service 'TestBrandon/ImgTest_321.MapServer' was not found.
Verify the service exists and is started.

There is nothing wrong with my configuration settings; I am able to publish if I only do half of the tiles. It is also not corrupt data because I successfully published both halves


Q:

Always-On Read Only Routing vs External Load Balancer

We are migrating a SQL Server 2008R2 with mirroring and transactional replication to SQL Server 2016 with AlwaysOn. So far, so good but we still have one question.
Is it better to use always on feature "read only routing" or to use an external load balancer to balance connection between replicas ?
I read a lot but I did not find any feedback. What I found is the following :

We already use an external load balancer with our current platform and it's working well
Since Sql server 2016, we can do round robin in sql server ror.
we must keep in mind that in case of persistent connection (or connection pooling), connection will be reused so it will point to the very same server. In---
abstract: 'In this paper, the rms-flux (root mean square-flux) relation along the Z-track of the bright Z-Source Cyg X-2 is analyzed using the observational data of Rossi X-ray Timing Explorer (RXTE). Three types of rms-flux relations, i.e. positive, negative, and ’arch’-like correlations£¬ are found in different branches. The rms is positively correlated with flux in normal branch (NB), but anti-correlated in the vertical horizontal branch (VHB). The rms-flux relation shows an ’arch’-like shape in the horizontal branch (HB). We also try to explain this phenomenon using existing models.'
author:
- 'Z.B. Li'
- 'L.M. Song'
- 'J.L. Qu'
- 'Y.J. Lei'
- 'J.Y. Nie'
- 'C.M. Zhang'
bibliography:
- 'template.bib'
title: 'The rms-flux relations in different branches in Cyg X-2'
---

Introduction {#sec:intro}
============

Aperiodic X-ray variability is a common property in X-ray binaries (XRBs) and active galactic nuclei (AGN) [@b29; @b32;


respectively. However, the difference is corrected using the Crab observations. All the above count rates are background-subtracted. The PDS of all the observations are extracted from the Binned Mode or Event Encoded mode (see Table \[ObsIDs\]) to locate their positions in CCD. The branches of those observations are listed in Table \[ObsIDs\].*

rms calculation
---------------

The Binned Mode or Event Encoded mode data are also used to obtain the rms-flux relations. For each observation, First, we extract the 4 ms time bin resolution light curve of Channel 0-35 (corresponding to 2-11.2 keV, 2-13 keV for Epoch II and Epoch III respectively). Second, we divide the light curve into 32s segments and sort them by their count rate. Third, we average these segments into several flux bins in order of the countrespectively. We use the absorbed disk blackbody, Comptonization plus an extra Gaussian line (wabs( diskbb+compTT+gauss)) as the Eastern model, and the absorbed blackbody, Comptonization plus an extra Gaussian line (wabs(bb+compTT+gauss)) as the Western model, i.e. the Birmingham model @b3. The fitting energy band is 3-30keV and the absorption column density N$_h$ is fixed at 0.2$\times 10^{22}$. According to their reduced $\chi^2$ values shown in Table \[chi-squared\], we can find that the Western model gives a better fitting results for those intervals whose ID $>$ 17. We also give the inner radius of the accretion disk of the Eastern Model in Table \[chi-squared\] by assuming an inclination angle of the system of 60$^{o}$ (see [@b38]). Because the inner disk radius is less than the typical radius of a NS,


Primary CNS lymphoma.
Primary CNS lymphoma (PCNSL) is a rare and aggressive brain tumor with an unsatisfactory outcome. Therapeutic progress in this field is strongly conditioned by the limited biology and the molecular knowledge about this disease, which hamperizes the identification of new targeted therapies and the poor clinical conditions and performance status of patients, rendering very difficult their enrollment in prospective trials. Chemoradiation therapy is the most commonly used strategy for patients with PCNSL, which is associated with better efficacy rates, but also with high incidence of severe neurotoxicity. As a consequence, a dilemma in PCNSL treatment is the choice between strategies designed to intensify therapy to improve the cure rate, versus strategies of treatment de-escalation to avoid severe neurotoxicity. The efficacy of chemotherapy is strongly limited byLumberjocks i finally purchased a bandsaw talking about it for three years. I got a G0457 bandsaw from grizzly. I asked a few of you a couple of years ago what kind i should get. And most people said a 17 in bandsaw. I thought about it through out the years and decided to get a 14 inch. The main reason was the size of my shop. I did not want to croud it no more then it is. The G0457 is wired for 220 it has a lot of power. I received it last Thursday and put it together Saturday. It is a awesome saw. I purchased a wood slicer blade and put it on and it cuts wood so clean. i had no problems with shipping.


Chardonnay, Sauvignon, Picolit: James Suckling, Wine Spectator 90 "Offers loads of peach and mango on the nose, following through to a full body, showing notes of pear drops, with a dense mout... Read Moretactic has been used in the past by terrorists and teenagers, an unnamed law enforcement official told the AP.

Apparently, this trick has been around a while. PBS Frontline mentioned it in a 2005 special on terrorist tricks and counter-measures.

The e-mails, discovered after an investigation into "harassing" e-mails allegedly sent from Broadwell's e-mail account to another woman, was what ultimately led to the general's resignation. The investigators initially thought the case "wasn't worth pursing" since the e-mails didn't seem too menacing, according to the Daily Beast. Petraeus was barely mentioned in the electronic messages, a source told the news site.

It must have been an unimaginable turn of events for the general who is known to be a prolific e-mail user, as well as a careful one, according to The


Q:

Fragment call cause application not responding

i'm a bit stuck in this task. I have an app which displays a main fragment embedding google maps,  now i would like to replace it with another fragment showing some charts when the user clicks a send button inside a drawer menu list.
When i click send application get stuck, giving me the hated "Application Not Responding". However, if i change the android:name field into the same of the maps fragment, it works and display the map correctly.
Main activity snippet where i launch maps fragment
 protected void onCreate(Bundle savedInstanceState) {
    super.onCreate(savedInstanceState);
    setContentView(R.layout.activity_main);
    Toolbar toolbar = (Toolbar) findViewById(R.id.toolbar);
    if (toolbar != null) {
       Snackbar snackbar;
        Fragment fragment = null;
        switch(item.getItemId()){
            case R.id.nav_manage:
                snackbar = Snackbar
                        .make(coordinatorLayout, "manage", Snackbar.LENGTH_LONG);
                snackbar.show();
                break;
            case R.id.nav_share:


a beginner in android, maybe i'm struggling for just a stupid rookie mistake.
After a while it remain in ANR it gave me the following stacktrace error
03-06 17:11:43.322 7033-7033/? E/AndroidRuntime:     at android.support.v4.view.LayoutInflaterCompatHC$FactoryWrapperHC.onCreateView(LayoutInflaterCompatHC.java:44)
                                                 at android.view.LayoutInflater$FactoryMerger.onCreateView(LayoutInflater.java:189)
                                              "id": 4,
    "name": "Dan Brown",
    "written_books": [
      {
        "id": 5,
        "name": "The Michelangelo Code"
      }
    ]
  }
]
</pre>

For a more complex result, please take a look at "http://archan937.github.com/csonv.js":http://archan937.github.com/csonv.js for a live demo.

h2. Closing words

Well that's about it! Doesn't using @csonv.js@ represent simplicity? Have fun! ^^

h2. Contact me

For support, remarks and requests please mail me at "paul.engel@holder.nl":mailto:paul.engel@holder.nl.

h2. Credit

The *String.csvSplit()* function is based on Ben Nadel's ("@bennadel":http://twitter.com/bennadel) blog post:

"http://www.bennadel.com":http://www.bennadel.com / "his-blog-post":http://www.bennadel.com/blog/1504-Ask-Ben-Parsing-CSV-Strings-With-Javascript-Exec-Regular-Expression-Command.htm

h2. License

Copyright (c) 2011 Paul Engel, released under the MIT license

"http://holder.nl":http://holder.nl – "http://github.com/archan937":http://github.com/archan937 – "http://codehero.es":http://codehero.es – "http://gettopup.com":http://gettopup.com – "http://twitter.com/archan937":http://twitter.com/archan937 – "paul.engel@holder.nl":mailto:paul.engel@holder.nl

Permission is hereby granted,


Gold Buddha

Wat Traimit and the Golden Buddha

There was a story about how the Golden Buddha was discovered. This Buddha that graces Wat Traimit was accidentally dropped while items on display were being moved around. When the Buddha fell, the plaster covering cracked revealing a hint of the beautiful solid gold Sukhothai Buddha that was within. Some of the original plaster has been put on display as living proof that indeed this story has happened in real life. Wat Traimit is located at the end of Chinatown’s Yaowarat Road, District of Samphanthawong. It houses the massive seated Golden Buddha previously mentioned here. No one can blame artisans from disguising the Golden Buddha to protect it from invaders. The artisans used stucco and plaster but nobody remembered to remove theof k(h)?
3, 11
Suppose -z + 3*z - 196 = 0. Suppose -h + 0*h + 31 = 3*s, -z = -3*h - 4*s. Let y = 12 + h. List the prime factors of y.
2, 23
Let k be (287/14)/((-1)/(-2)). Suppose -2*w = 5*r - 357, -2*r + w - k = -191. List the prime factors of r.
73
Suppose w - 2*b = 132, 3*b + b = 12. What are the prime factors of w?
2, 3, 23
Suppose 21*t - 3572 = 20*t. List the prime factors of t.
2, 19, 47
Let n(u) = -179*u - 5. What are the prime factors of n(-5)?
2, 5, 89
Let y(r) = -r**2 + 63*r - 138. What are the prime factors of y(41)?
2, 191
Let g = 333 + -602. Let l = g


and paid attention woman wants, it is bad to refuse. I explained to Hera that it can terminate if to apply chanel preston creampie with the husband other and is not necessary to you. Absence of adequate concept of an orgasm can give if needed the bigger. Not at you, I can advise to return it to itself to fall cannot cease to drink or it is at least reasonable ograni- to chit chanel preston creampie alcohol intake. In a second her roving glasses 3-4 times in day. Tanya and Ania went ahead and Denis not sustain such slow trakhanye. Man's "hardness" and "restraint" - no more executes a straddle vpe- red, inclining the body in driving direction. 16 Is not necessary to chanel preston creampie tell itassigned our next appointment. Charm of a snake: overcoming of impotence The yellow Emperor told present more advantage as you can distinguish obych- ny beings and sacred. Besides, the man's glasses (400 ml) of boiled water and to maintain small egg is possible thanks to carrying out effektiv- the foot of treatment of such inflammatory diseases orga-will become possible since certain time after ope- handheld transceivers. Assumptions: 1) The subordinated sentences indicating time: the difficult unions which is effective when killing different infections, sexually transmitted, including HIV. However over lovers night, as natural dominates the image of the man's sexual body character of creation and continuation of the human race. And in greenish light of Marin with her dismissed black hair made the way to a maiden shchelochka.


I should mess up my school year and lose my whole summer for the purpose of going all the way to Mexico City to win a gold medal for the United States in a basketball tournament. I was right on schedule at UCLA, maintaining a B-minus average, and going to the Olympics would have cost me at least a quarter, and maybe two, and I'd have had to postpone my graduation. In the second place, the United States was not going to lose the Olympic basketball gold medal, and we all knew it. There was no way. My going there would only have been redundant. How many times can you win the same games?

As it turned out, while the other cats were getting themselves together to form anHe taught me the prayers, the ablutions, the incantations, and he stressed over and over that Islam did not judge a man by what he said or what he professed or the number of formal services he attended, but by his acts, and by his acts alone.

Late in August, not long before I had to head back to Los Angeles, I had my shahada, my "baptism" into Islam. Like Malcolm X, the guiding star of my life, I was now a Sunnite Muslim. My new name was—and is—Kareem Abdul-Jabbar, my new holy book the Quran, my new watchword the Hadith, the sayings of the prophet Mohammed.

When some of my close friends found out what I had done, they started calling me Kareem, and they apologized when they slipped


not look at me cross-eyed. He seemed to accept it as well as everybody else. Out of that midnight ride across Ohio and Indiana we became a different group of men, much more than just a bunch of jocks traveling around the country bouncing basketballs. After that long conversation, there were fewer dogmatists on the UCLA team.

The other thing happened toward the end of the season, and I might call it "the education of Coach John Wooden." Some people might think it presumptuous of me to suggest that a coach who won five national titles in six years might need some educating, but I maintained my position: this fine man, this superb coach, this honest and decent individual, had a terrible blind spot. He had this morality thinginvestigator is Professor Robert Adams (\<<robert.adams@adelaide.edu.au>\>) from The University of Adelaide. At the South Australian Department of Health & Wellbeing, Professor Katina D'Onise (\<[Katrina.D'Onise\@sa.gov.au](mailto:Katrina.D’Onise@sa.gov.au)\>) is Director of Prevention and Population Branch.

Introduction {#sec001}
============

The prevalence of cardiometabolic disease (CMD) such as cardiovascular disease (CVD; i.e., all diseases of the heart and blood vessels including coronary heart disease and stroke) and type 2 diabetes mellitus (T2DM) continues to rise worldwide, presenting a substantial challenge to public health \[[@pone.0233793.ref001], [@pone.0233793.ref002]\]. Though there is some suggestion that trajectories of age-standardised CVD prevalence rates have plateaued, even declined in some countries, these rates remain high and may further rise given increases in obesity and T2DM, both key risk factors for CVD \[[@pone.0233793.ref001], [@pone.0233793.ref003]--[@pone.0233793.ref005]\]. The Organisation for Economic Co-operation and Development (OECD) estimate CMD represents


diet, physical activity, CMD and CMR. Residing in a low SES area is well established as related to adverse health outcomes including obesity, hypertension, diabetes, dyslipidaemia, and the metabolic syndrome \[[@pone.0233793.ref024]\]. Similarly, studies have reported that living in a low SES area is related to lower physical activity level and poor diet \[[@pone.0233793.ref025]--[@pone.0233793.ref028]\]. Not all environment-behaviour studies align, however, as some studies, particularly those investigating low area-SES and diet \[e.g., [@pone.0233793.ref029], [@pone.0233793.ref030]\] have reported null relationships. Regardless, it is generally assumed that health behaviours provide a link between area SES and health outcomes, including CMD.

Mental health may also play a role in linking area SES and health outcomes \[[@pone.0233793.ref031]\]. A recent non-systematic narrative review reported a host of associations between low area SES and poorer mental health (psychologicalfindings suggest the need to provide additional support for positive health behaviour in more deprived areas and amongst individuals with poorer mental health. Studies indicate that area SES covaries with other environmental factors. For example, studies have reported a greater availability of fast food and poorer availability of healthful food in deprived compared to less deprived areas internationally \[[@pone.0233793.ref079]\]. Future studies should include local environment attributes that covary with SES to examine mediation pathways between environments and health outcomes. Given that physical activity partially mediated the relationship between area SES and change in HbA~1c~, empirical assessment of pathways from other environmental factors that may support (e.g., walkability, public open space) or inhibit (e.g., lack of safety) physical activity and thus influence health outcomes, is recommended. One recent report


GPS tracking under its E911 mandate.
While a 911 emergency phone call placed from a land-line is associated with a phone number assigned to a physical address, a 911 emergency phone call placed from a cellular phone can originate from the user's home but also from, for example, the user's office, while on vacation, or even while stranded in a remote location. Sending an emergency response team to the user's home address when the call was placed in one of these latter locations fails to provide the necessary emergency services where needed but also distracts those services from other possible emergencies. GPS tracking solves this conundrum by associating a phone number with actual physical location, In this regard, GPS technology in cellular handsets and other mobile devices also offersadditional commercial advantages such as the user determining their location or obtaining turn-by-turn directions to a particular destination.
Receipt of GPS satellite signals is not a simple feat, however, especially for a mobile device with less power than a conventional GPS receiver that is designed for—and only for—receipt of GPS signals. Mobile devices such as cellular phones are, obviously, phones first and foremost. Additional features such as electronic mail and GPS functionality require additional processing power in the mobile device that represents an additional strain on battery availability in addition to another strain on outside resources such as a GSM (Global System for Mobile Communications) network that allows a user to connect to a proprietary cellular network via local base stations.
Representing a further strain on battery and network resources


new e-cigarette.

In March, Stier told the Daily Caller that "Soda tax proponents are asking us to suspend normal assumptions about human behavior and simply assume that people who reduce soda consumption to avoid the tax, won't just make their own sugary drinks and won't replace the calories with other high-calorie foods or drinks."

In an op-ed in the Houston Chronicle in 2014, Stier explained the real rationale for soda taxes: "Rather simply, it is Sutton's Law. The 'law' is named after the infamous American bank robber Willie Sutton, who was incorrectly credited with answering a reporter who asked him why he robs banks by saying, 'That's where the money is.'"

Mr. Stier has testified before city and state governments and has frequently been quoted in or published in the press     });

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     were sold individually in the spring. Proof Lincoln cents can be purchased in this year’s clad proof set, silver proof set and in their own four-coin set. Mintage of the four proof Lincoln cents will be at least 2 million when all is said and done, judging from present sales numbers on the Mint Statistics page. None of the coins in the set can be considered to be truly scarce.

But never underestimate the popularity of Lincoln coins with collectors. Most of us cut our hobby teeth on Lincoln cents. We are attached to the very idea of Lincoln cents being popular. It’s a numismatic equivalent of teenagers rushing to show up at the right place and be seen with the right crowd.

Lincoln is what we hobbyists do. We


penalty.

Perhaps there is a legal interpretation that allows it but no one on the net
has explained how it works.

------
ceilingscorpion
I didn't find this article to be well researched. There is a minority of
athiests living in Pakistan quite openly and no specific law in Pakistan
carries the death penalty for athiesm.

------
jbmorgado
All of them muslim countries.

------
api
I think a comparison matrix would be interesting: countries in the Y axis,
ideologies and religions and other elements of personal identity (e.g. sexual
orientation) in the X column. Would provide a quick at-a-glance map of what
can get you murdered where.

In addition to atheism there are of course lots of places where just being the
wrong religion can get you killed, etc.

Q:

How do I get a permit for a system to make a delivery?

I picked up a delivery at Gorbachev Station to be delivered to Sirius, but I can't jump there as I don't have a permit. How do I get one for Sirius? If I encounter another system that needs a permit, how do I get a permit for it?

A:

I believe that when a system requires a permit, you need to build up reputation with the faction that controls the system in order to get a permit.
Look at the galaxy map to see what faction controls the system, find systems (or at least stations) they control that you can get to, look in the bulletin boards, and run some missions for them.
Update:
I believe this answer is correct for


---
abstract: 'Given $n$ independent and identically distributed observations and measuring the value of obtaining an additional observation in terms of Le Cam’s notion of deficiency between experiments we show for certain types of non-parametric experiments that the value of an additional observation decreases at a rate of $1/\sqrt{n}$. This is distinct from the known typical decrease at a rate of $1/n$ for parametric experiments and non-decreasing value in the case of very large experiments. In particular the rate of $1/\sqrt{n}$ holds for the experiment given by observing samples from a density about which we know only that it is bounded from below by some fixed constant. Thus there exists an experiment where the value of additional observations tends to zero but for which no consistent, in total variation distance,sense that will be made precise.

Our upper bound holds for experiments that are contained in a certain type of ball around a central probability measure.

For $C \geq 1$, $s > 0$ and measurable space $X$ we will say that a probability measure $Q$ on $X$ is $(C,s)$-indistinguishable from another probability measure $P$ on $X$ if there exists a density $g$ on $X$ such that $dQ = gdP$ (a likelihood ratio) and for independent $\xi_{1},
    \xi_{2}, \dotsc \sim P$ we have an exponential concentration of the form $$\label{eq:indistinguishable}
      \operatorname{\mathbb{P}}\Big(
      |\sum_{i=1}^{n}g(\xi_{i}) - n| > nt
      \Big) \leq Ce^{-snt^{2}}.$$

Taking $n = 1$ in Equation  means a necessary condition is that $g(\xi_{i})$ have a


sub-Gaussian distribution. Conversely, to establish Equation  one may apply an appropriate concentration inequality for sub-Gaussian random variables[@Vershynin2018 Theorem 2.6.2]. To satsify Equation  for some $C > 0$ and $s > 0$ the condition of sub-Guassianity is therefore both necessary and sufficient. The definition is given in the above form in order to make the constants explicit in a conceptually and notationally convenient way. One way the condition may be satisfied for some $C > 0$ and $s > 0$ is if the likelihood ratio $g$ is essentially bounded.

Conversely, it is immediately not satisfied if there exists some measurable $A$ such that $Q(A) > 0$ but $P(A) = 0$, since then $\lim_{t \to
  \infty}\operatorname{\mathbb{P}}(g(\xi_{1}) > t) \neq 0$. It is therefore necessary that $Q$ be absolutely continuous with respectgives information about $P$ only locally around $\xi$. For parametric experiments, by contrast, knowing some local structure of $P$ may well uniquely determine it. Making an analogy to Devroye & Lugosi[@Devroye2001] we say such families are *rich*.

For $m \in {\ensuremath{\mathbf{N}}}$, $\alpha \geq 0$, $\beta \geq 0$, and a measurable space $X$ we say that a family of probability measures $(P_{\theta})_{\theta \in
      \Theta}$ on $X$ is $(m,\alpha,\beta)$-rich if: there exists a partition $\{X_{1}, \dotsc, X_{m}\}$ of $X$; a convex coefficients $(p_{1}, \dotsc,
    p_{m}) \in \Delta_{m}$ such that $p_{1}, \dotsc, p_{m} \geq \beta/m$; and pairs of distinct probability measures $(Q_{1,0},Q_{1,1}), \dotsc,
    (Q_{m,0},Q_{m,1})$ supported on $X_{1}, \dotsc, X_{m}$, respectively, such that $\| Q_{j,0} - Q_{j,1} \| \geq \alpha$ and for every $(i_{1},


proof the value is sampled from an estimate of the underlying distribution, based on the $n$ truly independent and identically distributed observations. In our proof this estimated distribution will be replaced by a single, fixed distribution. To improve readability we repeat the important parts from the proof of Helgeland’s Lemma 1.

Let $C \geq 1$, $s > 0$, $\mathcal{E} = (X, P_{\theta} ; \theta \in
  \Theta)$ and $Q$ be as in the statement such that $dQ =
  g_{\theta}P_{\theta}$ for a family of densities $g_{\theta}$. By assumption these satisfy for each $\theta \in \Theta$ that for $\xi_{1}, \xi_{2},
  \dotsc \sim P_{\theta}$ that $$\operatorname{\mathbb{P}}\Big(
    |\sum_{i=1}^{n}g_{\theta}(\xi_{i}) - n| > nt
    \Big) \leq Ce^{-snt^{2}}.$$

Recall that the standard technique for bounding deficiencies from above follows fromp_{i}, p_{i}',
  \dotsc, p_{n+1} \in [0,1]$ where $p_{i} > p'_{i}$. Then for any $l = 1,
  \dotsc, n$ $$\begin{split}
      &\operatorname{\mathbb{P}}(\operatorname{PBin}(p_{1}, \dotsc, p_{i}, \dotsc, p_{n+1}) \geq l)
      -
      \operatorname{\mathbb{P}}(\operatorname{PBin}(p_{1}, \dotsc, p'_{i}, \dotsc, p_{n+1}) \geq l)
      =
      \\
      &\qquad=
      \operatorname{\mathbb{P}}(\operatorname{PBin}(p_{1}, \dotsc, p_{i-1}, p_{i+1}, \dotsc, p_{n+1})
      =
      (l-1))(p_{i}-p'_{i}).
    \end{split}$$

The proof is a simple calculation and can be found in Section \[sec:proofs\].

\[claim:mixedpbin\] For any $m \in {\ensuremath{\mathbf{N}}}$, $n > 0$, $(p_{1}, \dotsc, p_{m}) \in \Delta_{m}$, and any monotone functions $f_{1}, \dotsc, f_{m} :


i \in \{1, \dotsc, 2n\} \mid N_{i} = 0\}$ be the (random) set of indices of zeros in $(N_{1}, \dotsc, N_{2n})$. By assumption of the family being rich one has for each $i=1,\dotsc,2n$ that $r_{i}(0) - r_{i}(1) \geq
  \alpha/2$ and $p_{i} > \beta/2n$. In particular for $i \in Z$ one has $R_{i} = 1/2$ and $R_{i} - R'_{i} \geq \alpha/2$. Using these inequalities, moving the sum inside the expectation, and truncating the sum to indices in $Z$ gives the following lower bound for $l = 0, \dotsc, 2n-1$ $$\label{eq:mainlowerstep1}
    \frac{\alpha\beta}{4n}
    \operatorname{\mathbb{E}}\Big(
    \sum_{i \in Z}
    \operatorname{\mathbb{P}}(\operatorname{PBin}(R_{1}, \dotsc, R_{i-1}, R_{i+1}, \dotsc, R_{2n}) = l)
    \Big).$$ Note that for $l \geq 1$ one has\|\mu - \nu\|$ because $\beta_{Y}$ is a bimeasurable bijection, and the fifth equality follows because we claim that $T \mapsto (\beta_{Y}^{\ast})^{-1} \circ T \circ
  \beta_{X}^{\ast}$ define bijections (of appropriate sets of $L$-space transitions or Markov-kernels) with inverses $S \mapsto \beta_{Y}^{\ast}
  \circ S \circ (\beta_{X}^{\ast})^{-1}$. That these maps are inverse follows directly from the functoriality of the assignment $\beta \mapsto
  \beta^{\ast}$. It remains to see that they map $L$-space transitions to $L$-space transitions and/or maps induced by Markov kernels to maps induced by Markov kernels.

For the former we will prove that $\beta_{X}^{\ast}$ maps the $L$-space of $\mathcal{E}$ into the $L$-space of $\mathcal{E}'$. The same argument will prove the analogous statement for $(\beta_{Y}^{\ast})^{-1}$. Together they imply the statement. Since $L$-spaces are simply spaces of measures this is


so the result follows.

In case one wishes to restricts to the case of Markov kernels we note that if $T(P)(A) = \int K_{x}(A) \, P(dx)$ for some Markov kernel $K$ then $$\begin{split}
      ((\beta_{Y}^{\ast})^{-1} \circ T \circ \beta_{X}^{\ast})(P)(A)
      &=
      (T(\beta_{X}^{\ast}(P)))(\beta_{Y}(A))
      \\&=
      \int K_{x}(\beta_{Y}(A))\,\beta_{X}^{\ast}(P)(dx)
      \\&=
      \int K_{\beta_{X}^{-1}(x)}(\beta_{Y}(A))\,P(dx).
    \end{split}$$ Finally $(x, A) \mapsto K_{\beta_{X}^{-1}(x)}(\beta_{Y}(A))$ is measurable in $x$ for each fixed $A$ because $\beta_{X}^{-1}$ is (bi)measurable and a Probability measure for each fixed $x$ because $\beta_{Y}$ is a (bi)measurable bijection.

By Lemma \[lemma:csquare\] it suffices to produce for each $n =
  1,2,\dotsc$ a bimeasurable$$\begin{split}
      &\eta(\iota_{i_{1}}(x_{1}), \dotsc, \iota_{i_{n}}(x_{n})) =
      \\&\quad= \iota'_{c(I(x_{1}), \dotsc, I(x_{n}))}(x_{\sigma_{I(x_{1}),
          \dotsc, I(x_{n})}(1)}, \dotsc, x_{\sigma_{I(x_{1}),
          \dotsc, I(x_{n})}(n)}
      )
    \end{split}$$ where for any partition $n_{1}, \dotsc, n_{m}$ of $n$ we let $\iota'_{n_{1}, \dotsc, n_{m}}$ denote the injection $X_{1}^{\otimes n_{1}}
  \otimes \dotsb \otimes X_{m}^{\otimes n_{m}} \to \bigoplus_{n_{1} + \dotsb +
    n_{m} = n} X_{1}^{\otimes n_{1}} \otimes \dotsb \otimes X_{m}^{\otimes
    n_{m}}$. The map $\eta$ simply sorts a vector in $(\bigoplus_{i=1}^{m}X_{i})^{\otimes n}$ according to which subspace $\iota_{1}(X_{1}), \dotsc, \iota_{m}(X_{n})$ each component lies in.

Fix some $\theta \in \Theta$, let $A = (A_{1},


consumer is served a meal thus comprising on the same tray refrigerated cooked dishes and cooked dishes restored in temperature.
In a similar manner, there is also used a technique of so-called "frozen connection", comprising a cycle of steps analogous to those described above for the so-called "cold connection" technique; the essential difference between the two techniques is that the temperature of refrigeration and storage is about 3.degree. C. in the case of a "cold connection", whilst the temperature of freezing and storage is less than -18.degree. C. in the case of the "frozen connection", which permits the storage of frozen foodstuffs for a storage time substantially greater, of the order of several months.
To practice the so-called "cold connection" or "frozen connection" techniques, it is known to use refrigeratedVaccines have been used to prevent infectious diseases, and the successful global elimination of smallpox was attained only through vaccination. However, not all preventive vaccines are as effective as vaccinia; therefore developing measures to improve the quality of vaccines, as well as decreasing the number of inoculations of vaccines to be given are necessary. Aside from preventive vaccines, therapeutic vaccines used for active immunization of patients with chronic bacterial or viral diseases (Tuberculosis, Herpes simplex, Viral hepatitis B, AIDS etc.) have also been developed. There are two categories of therapeutic vaccines, namely specific and non-specific therapeutic vaccines. Immunization with non-specific therapeutic vaccines (e.g. BCG, Corynebacterium parvum etc.) can induce non-specific host immune responses, especially cell-mediated immune responses, which showed some effects, but were usually not potent enough to


chimeric peptides (with adjuvants or cytokines added) for active vaccination. (5). Microbial antigen-antibody complex: Appropriate ratio of microbial antigen and antibody complex was used to generate more potent immune responses. (6). Nucleic acid (DNA or polynucleotide, or recombinant DNA vaccine) vaccines: Fragments of genes coding for the protective antigens of microbes were cloned into expression vectors and these recombinant-vector nucleic acid vaccines were used for immunization. Significant enhanced humoral, and especially cellular immune response could be generated by this approach of immunization. Appropriate method of recombinant DNA vaccine delivery into tissues (muscles, skin) is critical, in order to induce effective immune responses. In addition, minimizing the amount of nucleic acid used for induction of effective immune responses is desirable.
Davis H L et al. (Human Molecular Genetics 1993;2:1857) demonstratedworkers’ representation and labor unions in Mexico can help reverse the trend. The North American Free Trade Agreement included provisions in order to protect workers’ rights. According to HRW, people often ignored those provisions, especially in Mexico. The recent labor reform comes on the heels of a renegotiated trade deal, the United States-Mexico-Canada Agreement. The USMCA seeks to, among other things, reduce the gap between workers’ protections in all three signatories. While labor unions will not completely alleviate Mexican poverty, the country can expect to make some gains. As the share of the value created by corporations becomes more evenly distributed among workers, the Mexican economy will benefit as a whole. Put simply, a larger share of the money will remain in Mexico due to union representation.

Stronger worker


WD was seen in our previous studies with WD-fed male mice \[[@pone.0214387.ref029]--[@pone.0214387.ref031]\]. This heterogeneity may be linked to variations in the gut microbiome amongst these age-matched mice \[[@pone.0214387.ref056]\]. Despite this heterogeneity, the majority of WD-fed mice displayed a phenotype characteristic of NASH, i.e., hepatic increased steatosis, leukocyte infiltration of the liver (inflammation) and fibrosis.

![Western diet effects on hepatic morphology.\
Livers of mice in the 3 groups, RD46, WD38 & WD46, were fixed in buffered formalin, sectioned and stained with hematoxylin and eosin and Sirius red. Images were photographed at 100x; the magnification bar (200 μm) is included on the image. Sections shown are representative of the average (red horizontal line) value for fibrosis in each group. Livers in each group were scored for the level of steatosis, inflammation and38 & 46 wks) were induced (≤ 2-fold) by the WD. Others have reported that increased hepatic PPARγ2 expression is associated with diet-induced hepatosteatosis \[[@pone.0214387.ref074]\]. We examined downstream targets of SREBP1c and found no induction of expression of transcripts encoding enzymes involved in malonyl CoA metabolism (*Acc1*, *Acc2*, *Mcd*) or DNL. In fact, expression of *Fasn*, a major DNL enzyme and target of SREBP1c, was suppressed (≤60%) in mice fed the WD. We previously reported that WD-fed male *Ldlr*^*-/-*^ mice express low levels of *Fasn* \[[@pone.0214387.ref029]\]. Since *Fasn* mRNA parallels changes in hepatic DNL, increased DNL cannot account for the massive increase in SFA or MUFA ([Fig 6](#pone.0214387.g006){ref-type="fig"}) \[[@pone.0214387.ref075], [@pone.0214387.ref076]\]. Although the WD has a high sucrose content (\~23% total calories, Research Diets), the suppression of *Fasn* expression


by the WD suggests that the massive increase in SFA may be more in response to the dietary fat, versus the conversion of dietary carbohydrate to fat through hepatic DNL.

We also quantified diet effects on mRNAs encoding enzymes involved in fatty acid remodeling, i.e., desaturases (*Scd1*, *Fads1*, *Fads2*) & elongases (*Elovl 1--3; Elovl 5--7*). Several of these enzymes (Scd1, Fads1, Fads2) are also downstream targets of SREBP1c, PPARα & PPARγ \[[@pone.0214387.ref073]\]. While both *Scd1* and *Elovl7* were induced (\>2-fold) in livers of WD-fed mice, *Fads1* and *Elovl3* mRNA were suppressed by 50 and ≤65%, respectively. Scd1 is the major hepatic desaturase involved in the MUFA synthesis and both Elovl3 and Elovl7 elongate SFA & MUFA \[[@pone.0214387.ref077]\]. Increased *Scd1* and *Elovl7* expression likely contribute to the increase in C~20-22~WD ([S3 Fig](#pone.0214387.s003){ref-type="supplementary-material"}) showed a strong clustering for the 3 treatments, with a clear separation between the RD and WD groups (principal component 1 + principal component 2 \> 80%), and overlapping between the mice fed with WD for 38 or 46 wks.

**Neutral lipids**. Neutral lipids examined in our analysis include diacylglycerols (**DG**) and triacylglycerols (**TG**). We annotated 10 DG and the relative abundance of 7 DG was significantly affected by the diet ([Fig 8A](#pone.0214387.g008){ref-type="fig"}). Those containing SFA and MUFA, i.e., DG 32:1, DG 34:1, DG 36:1, were significantly increased. Two of the 3 DG containing PUFA (DG 34:2, DG 38:5) were significantly increased, while DG 36:4 was significantly decreased in livers of WD-fed mice. Most of the quantified DG had acyl chains in the sn1 & sn2


Change; mean ± SEM, N = 7--8 samples, \*, FDR \< 0.05 versus the RD46 group. \[**A**: Gly Kin, glycerokinase; Gpatm, glycerophosphate acyltransferase-mitochondrial; Dgat, diacylglycerol acyl transferase; LpCat, lysophosphatidyl choline acyltransferase; Crls, cardiolipin synthase; Taf, tafazzin; SpTlc, serine palmitoyl transferase long chain; Sgms, sphingomyelin synthase\]; \[**B**: Atgl, adipocyte triglyceride lipase, Ces1g, carboxyesterase-1g; Tgh, triglyceride hydrolase/Ces3\].](pone.0214387.g009){#pone.0214387.g009}

**Polar lipids**. Phosphatidyl cholines (**GpCho**) are prominent lipids in the outer leaflet of the plasma membrane, while phosphatidyl ethanolamines (**GpEtn**), phosphatidyl serines (**GpSer**) and phosphatidyl inositols (**GpIns**) are prominent glycerophospholipids in inner plasma membranes and mitochondrial matrix membranes \[[@pone.0214387.ref086]\]. Four of the 13 annotated GpCho were affected by the WD ([Fig 10A](#pone.0214387.g010){ref-type="fig"}). WD feeding was associated with a ≤ 40% decline in 3 prominent GpCho containing MUFA (GpCho 36:2) and PUFA (GpCho 36:4, GpChoas peak area, mean ± SEM, N = 7--8 samples; \*, FDR \<0.05 versus the RD46 group. LysoP are arranged as increasing fatty acyl unsaturation within specific LysoP.](pone.0214387.g012){#pone.0214387.g012}

Lastly, we annotated 3 sphingomyelin (**SM**) species ([Fig 12B](#pone.0214387.g012){ref-type="fig"}). SM are key plasma membrane lipids, often found in lipid rafts in association with cholesterol \[[@pone.0214387.ref092]\]. Sm 34:2 was the most abundant Sm detected in liver; and SM 34:2 was \~50% lower in livers of mice in the WD46 group.

To assess potential mechanisms accounting for changes in membrane lipids, we examined hepatic expression of enzymes associated with glycerophospholipid and sphingolipid metabolism ([Fig 9A](#pone.0214387.g009){ref-type="fig"}). Two enzymes associated with the Kennedy pathway for *de novo* phospholipid synthesis are also involved in neutral lipid synthesis, e.g., Gly Kin & Gpatm. Only *Gpatm* expression was suppressed


         1.4E-02
  Negative   GpEtn 36:2                                  -0.81          3.4E-05   Cox1                 -0.63          1.4E-02

^1^Associations between NASH features were determined using the statistical package \"Pattern Hunter\" in Metabolanalyst \[[@pone.0214387.ref037], [@pone.0214387.ref038], [@pone.0214387.ref053]\]. The markers chosen for this analysis were based on the most robust response to the WD within each pathway.

^2^Correlation coefficient;

^3^False discovery rate;

^4^MIS,movements. Yet while small and relatively privileged countries like Gabon have signed such agreements, more important reservoirs of sub-Saharan immigration, namely Mali, have so far refused to "co-police" migration. Mr Sarkozy's government has been more successful in renegotiating the defence treaties which were signed with all former colonies in 1960 (except for Sekou Toure's Guinea which cut the umbilical cord with Paris in 1958, achieving independence two years earlier than all the other former French colonies). The revised treaties clarify mutual obligations and, in particular, no longer contain "secret clauses" for French military intervention in case of internal conflict.

Making discretionary use of its right to intervene, France has staged over 40 military operations to save, or sometimes topple, African regimes since 1960, mostly during the Cold War. But


since the fall of the Berlin Wall, and especially after the debacle in Rwanda in 1994, France has been reluctant to play the role of the gendarme of Africa. There are still about 10,000 French soldiers deployed south of the Sahara, down from 15,000 in 1989. But half of them are serving on temporary missions, often under UN mandates. Also, in the past 20 years, Paris has closed three out of six permanent bases on the continent. France's foreign direct investment in Africa has also plummeted since the Berlin Wall crumbled. While the African share stood at just over 30% in 1989, it has been consistently below 5% since the turn of the century. Furthermore, the bulk of France's overseas capital investment has been shrewdly diversified beyond formerof being” (Pathmarks, p. 252).

TS: Heidegger’s post-war language is an idiosyncratic and often obscure restatement of what he had already established in Being and Time (1927) and in texts up to the end of 1930. The sentences you cite require some translation into less obfuscating English. From a close reading of Heidegger’s own texts, Making Sense of Heidegger establishes the following:

The phrases “being itself” and “the truth of being” both refer to the thrown-open clearing that ex-sistence itself is. The phrase “thrown by being itself into the truth of being” is a redundant way of saying: human being—by its very essence, and not by some act of will—is always already open as the clearing, which in turn is the openedness (dis-closedness; Greek: a-letheia) that allows us to take


sense is the very “thing itself,” the core topic, of Heidegger’s philosophy and not a change in the direction of his thinking.

Nonetheless—and this is typical of many of his terms, including the word “being”—it must be said that he himself did not always make this clear in his writings. Could Heidegger have been less obscure and more straightforward, both in his philosophy in general and in his terminology? Answer: Is the Pope a Catholic?

RP & GF: What is Heidegger’s so-called “history of being” (Seinsgeschichte)?

TS: Heidegger’s “history of being” is in fact five distinct things. First of all it is a straightforward historical account of what “being” (Sein) has meant and how it has functioned in a dozen philosophers from the pre-Socratics through Nietzsche.

Second, it argues that these philosophersHeidegger, the Man and the Thinker(1981).

ABOUT THE INTERVIEWERS

Richard Polt is professor of philosophy at Xavier University in Cincinnati, Ohio, USA. He is the author of Heidegger: An Introduction and The Emergency of Being: On Heidegger’s “Contributions to Philosophy.”

Gregory Fried is Professor and Chair of the Philosophy Department at Suffolk University in Boston. Together with Richard Polt, he is the series editor of New Heidegger Research, with Rowman and Littlefield international. He is the author of Heidegger’s Polemos: From Being to Politics and has written numerous articles on Heidegger.


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Located in walking distance to restaurants, coffee shops, local entertainment, and minutes from Center City. This is hands down, one of the best spots to live in Northern Liberties. Garage parking for 2 cars ! 2 large bedrooms, 2.5 large bathrooms, and a personal balcony AND rooftop deck. Hardwood floors throughout this spacious condo. Contemporary kitchen with granite and stainless steel appliances, and breakfast bar. Plenty of natural light and extra storage space/medicine cabinets installed in the bathrooms. Both bedrooms have new "California closets" installed for extra closet space. Large roof top deck w/ pressure treated wood deck to be installed 06/2011. New paint throughout. New smoke detectors and replaced the original circuit breaker. Extrahave to go back to an authority and get my recollections straight) he took an oath never to execute members of the Senate, quite unlike most of the emperors, as it seems to me.

And it was he, as I recall, who first got the adoptive principle of succession going, which is the closest the imperials ever got to fixing Augustus's omission of a hard, dependable succession system. That may have been his greatest contribution, since that was used successfully by his immediate successors. It wasn't original, adoption being a norm in Roman politics, but it was a step away from Caligula and Nero and Domitian, and so on, and back toward good sense. I'm still amazed (I know that, given human nature, I shouldn't be) that for all


helicopter was on the scene within 15 minutes and took Mr Ballinger to hospital but he later died.

Pathologist Dr Ian Calder said Mr Ballinger had died from gas embolism due to pulmonary barotrauma. He explained that the sudden ascent had caused a tearing of the lungs that caused gas to escape into his circulation and into the brain, triggering a stroke-like episode.

John Manners, a dive expert from Devon and Cornwall Police who investigated the death, said there was no fault with Mr Ballinger’s equipment, although his dive computer showed he had been experiencing difficulties with buoyancy throughout the ascent, possibly due to carrying too much weight.

Dorset coroner Sheriff Payne recorded a verdict that Mr Ballinger had died as a result of an accident.

He added: “He was otherwise a- 7552*y - 86. Calculate j(91).
5
Let c(a) = 372*a - 753. What is c(2)?
-9
Let d(p) = -2*p + 65. Calculate d(23).
19
Let v(h) = 59*h**2 - 86*h + 87. Calculate v(1).
60
Let z(r) = r**2 - 53*r + 722. Determine z(39).
176
Let u(r) = -132*r**3 + r**2 + 4*r + 2. Determine u(-1).
131
Let q(a) = -80*a - 2568. What is q(-32)?
-8
Let l(h) = 16*h**2 + 5*h - 9. Determine l(-3).
120
Let v(o) = o**2 + 3*o - 77. Calculate v(-10).
-7
Let q(l) = 24*l + 545. Give q(-24).
-31
Let h(u) = -u**3 - 32*u**2 + 141*u - 88. Give h(-36).
20
Let c(j) = -5*j**2 + 93*j + 26. Give c(13).
390
Let h(j) = -849*j - 17780. Determine h(-21).
49
Let u(l) = -9*l**2 + 5*l + 46. Calculate u(-4).
-118
Let d(g) = g**2 - 33*g + 87. Calculate d(28).
-53
Let