we use to obtain the last estimate.

The second lemma shows that a finite set of lines of exponential size controls all lines, up to an ultimately negligible error.

\[lem:many-lines-to-all-lines\] For each $n$, there is a (deterministic) family of lines $\mathcal{A}_n\subset\mathcal{A}'$ such that $\#\mathcal{A}_n \le O(1)^n$, and $$\sup_{\ell\in \mathcal{A}'}Y^{\ell}_n\le\sup_{\ell\in \mathcal{A}_n}Y^{\ell}_n +  O(2^{-n}),$$ for any realization of $A$.

We construct a family of lines ${\mathcal{A}}_n$ with $O(1)^n$ elements such that given any line $\ell\in{\mathcal{A}}'$, there is $\ell'\in{\mathcal{A}}_n$ such that $$\label{gg'}
\mathcal{H}^1(\ell \cap Q)\le \mathcal{H}^1(\ell' \cap Q)+O(8^{-n})\quad\text{ for any } Q\in\mathcal{D}_n.$$

We first assume that $d=2$. Recall that $D$ is the Hausdorff distance between closed subsets of the unit cube. By elementary geometry, there is ${\mathcal{A}}^0_{n}\subset{\mathcal{A}}'$ with $O(1)^n$ elements which is $64^{-n}$ dense in the $D$ metric. For each horizontal dyadic line $$\ell_k=\{(x,y)\in{\mathbb{R}}^2\mid y=ksimilar deferred compensation agreements with
other members of the senior management team.
   In 1994, Greater Omaha terminated Acklie’s employment,
and in 2006, Acklie turned 60 years old. In 2011, Acklie
demanded payment from Greater Omaha under the terms of
the agreement. He contended that his right to deferred com-
pensation vested upon his attaining age 60 and that payment
became due on the first day of the first month following his
attaining age 61. The agreement’s vesting provision, paragraph
6, provides:
      The Employee’s Deferred Compensation Account shall
      be one hundred percent (100%) vested upon and after
      the earlier of his completing ten (10) consecutive years
      of service commencing the date first above written or


interest in the account
was $18,574.92.
                             - 111 -
         Nebraska Supreme Court Advance Sheets
                  306 Nebraska Reports
             ACKLIE v. GREATER OMAHA PACKING CO.
                        Cite as 306 Neb. 108

   Greater Omaha moved to dismiss the complaint, argu-
ing that Acklie’s rightsenforce a contract has the bur-
den of establishing the existence of a valid, legally enforce-
able contract. 11 To create a contract, there must be both an
offer and an acceptance; there must also be a meeting of the
minds or a binding mutual understanding between the parties
to the contract. 12 It is a fundamental rule that in order to be
binding, an agreement must be definite and certain as to the
terms and requirements. 13 It must identify the subject matter
and spell out the essential commitments and agreements with
respect thereto. 14
10
     Sindelar v. Canada Transport, Inc., 246 Neb. 559, 520 N.W.2d 203 (1994).
11
     Houghton v. Big Red Keno, 254 Neb. 81, 574 N.W.2d 494 (1998).
12
     Id.
13


(1991).
     See, 17 C.J.S. Contracts § 135 (2011); 17A Am. Jur. 2d Contracts § 22
     (2016).
17
     Floss v. Ryan’s Family Steak Houses, Inc., 211 F.3d 306 (6th Cir. 2000);
     Davis v. General Foods Corporation, 21 F. Supp. 445 (S.D.N.Y. 1937).
18
     Floss, supra note 17, citing 1 Samuel Williston, A Treatise on the Law
     of Contracts § 43 (3d ed. 1957); Davis, supra note 17. See Midland Steel
     Sales Co. v. Waterloo Gasoline Engine Co., 9 F.2d 250 (8th Cir. 1925).
19
     Fagerstrom v. Amazon.com, Inc., 141 F. Supp. 3d 1051 (S.D. Cal. 2015),
    Court Advance Sheets
                      306 Nebraska Reports
                 ACKLIE v. GREATER OMAHA PACKING CO.
                            Cite as 306 Neb. 108

does not constitute an enforceable agreement. 21 As relevant
here, an agreement to pay such wages as the employer desires
is invalid. 22
   In De Los Santos v. Great Western Sugar Co., 23 this court
considered a breach of contract action brought by a contrac-
tor which agreed to transport


Thread Co., 132 Me. 94, 167 A. 79 (1933);
     Horizon Corp. v. Westcor, Inc., 142 Ariz. 129, 688 P.2d 1021 (Ariz. App.
     1984); Mezzanotte v. Freeland, 20 N.C. App. 11, 200 S.E.2d 410 (1973).
     See, also, Chadd, supra note 20.
31
     See De Los Santos, supra note 15.
32
     Spanish Oaks v. Hy-Vee, 265 Neb. 133, 655 N.W.2d 390 (2003).
33
     Cimino v. FirsTier Bank, 247 Neb. 797, 530 N.W.2d 606 (1995).
                                   -106 S.Ct. 3229, 92 L.Ed.2d 650 (1986)). There is, however, an exception to the well-pleaded complaint rule known as artful pleading.
"Under the doctrine of `artful pleading,' a court is permitted to look behind a complaint to determine whether a plaintiff is attempting to conceal the federal nature of his claim by fraud or obfuscation." In re Wireless Tel. Radio Frequency Emissions Prod. Liab. Litigation, 216 F.Supp.2d 474, 492 (D.Md.2002) (citation omitted). Artful pleading is best described as "the manner in which some plaintiffs ... manage to plead claims that are actually federal ... under state law." Id.
Two categories of artful pleading cases are firmly established: cases involving complete preemption of state law by federal law, see, e.g., Rivet v. Regions Bank of Louisiana, 522 U.S. 470, 475, 118


judgment, the Court may well have intended to reject Sarkisian as well as Rivet. See 14B Charles Alan Wright et al., Federal Practice and Procedure § 3722, at 443 (1998) (stating that the Court explicitly rejected the Second Circuit's interpretation of the Moitie footnote).
This view of Rivet draws support from the fact that the "forum election" interpretation is partially based on the premise that removal is appropriate where a plaintiffs state law claims are virtually identical to those of a federal claim. This element of the "forum election" interpretation is analogous to the claim preclusion requirement that the claims in the second matter are based upon the same cause of action involved in the earlier proceeding.
For these reasons, I find that the "forum election" approach advanced by theSecond Circuit in Sarkisian was overruled by the Supreme Court in Rivet. Accordingly, the State's motion to remand will be granted.[4]
A separate order to that effect is being entered herewith.[5]

*741 ORDER
For the reasons stated in the accompanying memorandum, it is, this 31st day of
December 2002
ORDERED that
1. Plaintiffs motion to remand is granted;
2. Plaintiffs motion for attorneys' fees and costs is denied; and
3. This action is remanded to the Circuit Court of Boone County, West Virginia.
NOTES
[1]  The Fourth Circuit has never addressed the meaning of Moitie's footnote two.
[2]  The only authority cited by Microsoft in support of its argument is Metro. Council, 144 F.3d at 1171. In Metro. Council, the Eighth Circuit, upon remand from the Supreme Court, addressed whether its earlier opinion affirming the district court's


version of your website, below you can find a list of resources and applications that will help you successfully fulfill your aim:

Mippin is a fantastic tool for those who want to mobilize an RSS-driven site. It’s much quicker to use and the results look great, every time. What’s more, your site will be optimized to work on over 2,000 handsets and the service is completely free. It provides users with basic analytics in reports, as well as the ability to earn money through mobile advertising.

At last count, 31,912 websites had been optimized for mobile phones using Wirenode, though this tool offers slightly more than Mippin. Using Wirenode’s users can configure their domain name, upload pictures, track visitors and page views and preview their site on an emulated phone.MDA-MB-231 cell proliferation, apoptosis and TNBC development. Comprehensive gene expression analysis of these cells with or without miR-1207-5p inhibitor should be performed in future studies to understand its real effects.

Not applicable.

Funding
=======

No funding was received.

Availability of data and materials
==================================

The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.

Authors\' contributions
=======================

XH, ZN and LL performed the experiments and analyzed the data. QG, HL and XY conducted the experiments. XZ conceived the study, analyzed the data and prepared the manuscript.

Ethics approval and consent to participate
==========================================

Written informed consent was obtained from each patient. The present study was conducted in accordance with Declaration of Helsinki and was approved by the Institutional Review Board of Linfen People\'s Hospital (Shanxi, China).

Patient consent for publication
===============================

Not applicable.

Competing interests
===================

The authors declare


and healthy volunteers were included in the study. Patients diagnosed with arthritis prior to psoriasis and non-Kashmiri population was excluded from the study. A detailed history was taken from all patients, and a complete clinical examination was carried out. The severity of disease was assessed on the basis of psoriasis area and severity index (PASI). PASI ranges from 0 to 72 with PASI \> 10 recognized as indicative of severe disease. In addition, routine investigations, wherever deemed necessary, were carried out. The blood samples from the psoriasis patients and controls were obtained and were collected in 5 ml collection vials containing ethylenediaminetetraacetic acid and immediately stored at −80°C. Genomic DNA from the blood samples was isolated using a kit based method \[[Figure 1](#F1){ref-type="fig"}\]. The kit used was quick-gpsoriasis in 4 (4%) patients. Nail changes were observed in 38 (38%) patients. The PASI score was more than 12 in 23 (23%) patients and \<12 in 77 (77%) patients. Genomic DNA was successfully isolated from all 200 samples (100 cases and 100 controls).

The genotype for the common *LCE3C_LCE3B* deletion in 100 psoriasis patients and 100 controls was determined \[[Figure 2](#F2){ref-type="fig"}\].

![Representative gel picture depicting *LCE3B_3C* ins/del genotypes. The *LCE3B_3C* insertion and deletion alleles were visualized as polymerase chain reaction fragments of 240 and 199 bp. Lane 1, 2, 4, 8 and10: Cases homozygous for insertion. Lane 3 and 7: Cases heterozygous for insertion and deletion. Lane 5, 6, 9 and 11: Cases homozygous for deletion. Lane 12: DNA ladder (molecular weight marker)](ABR-5-109-g002){#F2}

Genotype and allele frequencies for the *LCE3C_LCE3B-del*


and psoriasis.\[[@ref31]\]

A meta-analysis including 12,196 psoriatic patients and 13,092 controls from 19 comparative studies, conducted by Song *et al*. however demonstrated a significant association between psoriasis and *LCE3C_LCE3B-del* polymorphism in Europeans and Asians.\[[@ref32]\]

On comparing the genotype frequencies for the *LCE3C_LCE3B-del* between sporadic and familial cases, the D/D frequency was higher (50%) among familial cases compared to sporadic cases (44.2%). The difference, however, was not statistically significant (*P* = 0.719). Coto *et al*. found a higher D/D frequency of 39% among sporadic cases compared to familial cases where the D/D frequency was only 24%.\[[@ref14]\] In a study\[[@ref33]\] in Tunisian psoriatic population, frequency of the *LCE3C_LCE3B-del* was similar between patients and healthy controls but subanalyses by family history revealed that the frequency of *LCE3C_LCE3B-del* was significantly higher in patients withof methods have been used. Rheological methods inform as to the mechanical properties, but the network type has to then be inferred.^[@ref18],[@ref19]^ Techniques such as infrared spectroscopy or circular dichroism can provide information as to the molecular packing, but cannot provide detail about the network. It is most common for a range of microscopy techniques to be used.

Moving down in microscopy length scales, optical microscopy simply cannot provide the necessary resolution to image the self-assembled fibers. Confocal microscopy can provide information at a relatively large length scale (although these techniques are improving constantly, and there are some extremely effective high resolution methods that are just coming on line).^[@ref20],[@ref21]^ However, for confocal microscopy, either the molecule has to be synthetically adjusted such that it is fluorescent, which is likely


to change its self-assembly behavior, or a fluorescent stain has to be added, which may affect the system. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) have been widely used.^[@ref22]^ Both of these methods usually require that the gel is dried. Further, for SEM it is common to sputter a metal onto the structures, and for TEM it is common to stain the structures, for example, with a heavy metal salt. The structures are then imaged under high vacuum. Although it is commonly assumed that the structures are related to those in the native, wet gel, there is often little evidence that this is the case. Cryo-SEM can be used, but there can easily be artifacts arising from freeze-concentration effects. In some cases, cryo-TEM is used.^[@ref23],[@ref24]^ Here,dried inside an incubator at 25 °C to ensure temperature fluctuations did not affect the drying process. Freeze-dried samples were kept in the mold and placed into a lab freezer at −20 °C for approximately 7 h before being placed into a Labconco freezone 4.5 freeze-dryer with a condenser temperature of −50 °C and a shelf temperature of 20 °C overnight. A small number of samples were placed in liquid nitrogen instead of the lab freezer prior to freeze-drying.

Analytical Techniques {#sec2.3}
---------------------

### Small Angle Neutron Scattering (SANS) {#sec2.3.1}

Solutions were prepared as described for other techniques, with D~2~O and NaOD (unless otherwise stated). Gels were prepared as above using GdL. UV spectrophotometer grade, quartz cuvettes (Starna) with a 5 mm path length were filled with the solution immediately after the


in the face. Being busy I didn't have time to wipe it off until the end of my shift. My fellow partners thought it was hilarious and started calling me Becky Mochaface. It stuck and I've grown partial to it.an annual basis.
If it passes, the township’s total EIT would drop from .75 to .625 percent, according to township Manager Richard Fisher.
The open space fund was approved by voter referendum in May 2007, but township officials say the account is... Read more

ready to go in the morning. Although every now and then he does forget.
“He runs out in his underwear sometimes," laughed Richard Fisher, a sanitation worker with Republic Services.
Logan is so excited to greet his garbage men that in the past,... Read more

ready to go in the morning. Although every now and then he does forget.
“He runs out in his underwear sometimes," laughed Richard Fisher, a sanitation worker with Republic Services.
Logan is so excited to greet his garbage men that in the past,... Read more

Carmen was sentenced


(2119)

(*P*\<0.05), differences tested by chi-square test

The prevalence of overweight, obesity and central obesity was significantly higher in the urban areas (*P*\<0.01); however, health-enhancing physical activity and smoking were significantly more prevalent in the regional areas (*P*\<0.001).

[Table 2](#T2){ref-type="table"} illustrates the prevalence of overweight, obesity, and abdominal obesity by age and sex. The prevalence of overweight, obesity and abdominal obesity were higher in middle**-**aged adults compared to young adults. Moreover, the prevalence of central obesity in normal weight subjects was 15.3% (men: 16.7%, women: 14.1%).

######

The prevalence of overweight, obesity, and abdominal obesity by age and sex

  ***Variables***                                                                0.61 (0.21, 1.78)                                           2.07 (0.70, 6.08)
  Unemployed                  1.93 (1.03, 2.99) [^\*\*^](#TFN5){ref-type="table-fn"}      0.81 (0.43, 1.52)


prevalence of overweight/obesity (63.6%) and abdominal obesity (75.2%) among adults. More longitudinal study is desired to investigate the association between socio-demographic factors and obesity.

Ethical considerations
======================

Ethical issues (Including plagiarism, informed consent, misconduct, data fabrication and/or falsification, double publication and/or submission, redundancy, etc.) have been completely observed by the authors.

The authors wish to thank the Tabriz Health services management research center at Tabriz University of Medical Sciences and Eastern Azerbaijan Governor General for financial support.

**Conflict of interest**

The authors declare that there is no conflict of interests.
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        $document = $word.documents.open("path to folder")
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        $hyperlinks | ForEach {
            $newURI = ([uri]$_.address).AbsoluteUri
            Write-Verbose ("Updating {0} to {1}" -f $_.Address,$newURI) -Verbose
            $_.address = $newURI
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        If (_$.address -eq "https://www.yahoo.com/") {
            $_.Address = "https://www.google.com/"
        } ElseIf ($_.Address -eq


than in the last several years for Waters.

Frost significantly affected Forgotten Hills Vineyard in 2008, 2009, and 2011 – not allowing winemaker Jamie Brown to make vineyard-designated wines (the juice was instead moved into the Wines of Substance Syrah). The jury is still out on whether a 2010 Forgotten Hills Syrah will make the grade. Things at Pepper Bridge Vineyard have been similarly challenging.

This makes the winery’s current releases from the 2008 vintage all the more special. The 2008 Loess Syrah, from Leonetti Cellar’s vineyard, and its Pepper Bridge counterpart are a study in contrast. The Loess is considerably more earthy with thirty percent dry stems added back, contributing to the wine’s tannins and mouthfeel. Ten percent Viognier was also added. The Pepper Bridge wine is considerably more10 countries have prescribed the use of the app among their patients for clinical and/or research purposes. Individual user feedback from doctors shows, that the most appreciated benefits of prospectively collected clinical data plus pollen counts is the increased diagnostic precision especially for poly-sensitized patients but also the improved adherence to SLIT (Fig. [9](#Fig9){ref-type="fig"}). As one of the main benefits of AllergyMonitor is the interaction and feedback from the doctor, the initiative to introduce AllergyMonitor into the patients'routine comes predominantly from the medical teams. Fig. 9Symptom monitoring of a pediatric patient with SAR during grass pollen SLIT**.** RTSS and pollen trajectories before starting SLIT (**a**) and after 1 (**b**), 2 (**c**) and 3 years of SLIT (**d**)

To evaluate the combined impact of molecular IgE results and mobile health technologies on


even better – maybe this is something that Barack Obama and Hillary Clinton (one of Rothschild’s buds) cooked up. Seriously, once this story breaks, no Republican apologist will ever be able to use the word “elitist” in public again. It’s brilliant – BRILLIANT, I say.

Because nobody – nobody – on the face of the Earth could be this lacking in self-awareness. You couldn’t even build a good stand-up routine around this because in order for something to be funny it has to be at least mildly grounded in plausibility.

But – apparently it’s actually really truly happening and not a joke or a campaign ploy. This hyper-privileged barking loon is serious.

You may have noticed the repeated references to “Lady” Rothschild. That’s apparently what she likes being called (and ifseen with loss of Cul3 ([Fig. 2c](#F2){ref-type="fig"}). Accordingly, endogenous Klhl12 effectively binds Cul3 in mESCs ([Fig. S4b](#SD2){ref-type="supplementary-material"}). These experiments, therefore, identify Klhl12 as a key substrate-adaptor for Cul3 in mESCs and the Cul3^Klhl12^ ubiquitin ligase as an important regulator of mESC morphology.

Cul3 monoubiquitinates Sec31 {#S3}
============================

To isolate the substrates of Cul3^Klhl12^, we constructed 293T cell lines that allowed for the inducible expression of ^FLAG^Klhl12. By affinity chromatography and mass spectrometry, we identified the COPII-proteins Sec13 and Sec31 as specific binding partners of Klhl12 ([Fig. 3a](#F3){ref-type="fig"}; [Table S2](#SD2){ref-type="supplementary-material"}). Immunoblotting confirmed retention of endogenous Sec13 and Sec31 in Klhl12-purifications, but not in precipitates of other BTB-proteins ([Fig. S5a](#SD2){ref-type="supplementary-material"}). As seen in pulldown assays, Klhl12 directly bound Sec31, but not Sec13 ([Fig. S5c, d](#SD2){ref-type="supplementary-material"}), and this interaction was mediated the N-terminus of


None of the 65 lysine residues of Sec31 was essential for ubiquitination by Cul3^Klhl12^, showing that Cul3 can target alternative lysine residues if the primary site is blocked. Despite this flexibility, Cul3^Klhl12^ does not stoichiometrically ubiquitinate Sec31. Thus, if Sec31-ubiquitination performs a structural role, then few ubiquitinated molecules must suffice to produce large COPII-coats, and these vesicles must tolerate considerable variation in the modification site. Alternatively, as often seen with monoubiquitinated proteins, modified Sec31 might recruit an effector that delays COPII-budding or promotes coat polymerization. As Cul3^Klhl12^ ubiquitinates other proteins ^[@R35]^, Sec31 may not be its only substrate in the secretory pathway. Identification of the complete set of Cul3^Klhl12^-substrates and potential effector molecules should reveal the mechanism underlying the ubiquitin-dependent regulation of vesicle size.

Our findings have the potentialto be translated into therapeutic strategies. We envision that agonists of Cul3^Klhl12^-function mitigate consequences of Sec23A-mutations in cranio-lenticulo-sutural dysplasia or Sar1-mutations in chylomicron retention disease ^[@R10],[@R11]^. By contrast, interfering with Cul3-activity may counteract increased collagen deposition during fibrosis or keloid formation ^[@R36]^. Given the strong clustering phenotypes observed in Cul3-depleted mESCs, inhibition of Cul3^Klhl12^ might impair the proliferation of metastatic cells, which display features of undifferentiated cells ^[@R37],[@R38]^. Thus, our identification of Cul3^Klhl12^ as a regulator of COPII size and function provides an exciting starting point to understand and therapeutically exploit key events in protein trafficking.

Methods summary {#S7}
===============

For stem cell culture, mouse D3 ESCs were maintained in GIBCO Dulbecco's Modified Eagle ESC medium containing 15% FBS, 1x sodium pyruvate, 1x NEAA, 1mM β-ME and 1000u/ml LIF (Millipore), and


total RNA was extracted using TRIzol as above. The expression of pluripotent markers, tissue specific genes and BTB genes in control and Oct4-depleted cells were analyzed using qRT-PCR.

Quantitative real-time PCR analysis {#S16}
-----------------------------------

We used TRIzol (Invitrogen, cat. \# 15596-026) and chloroform to extract total RNA from cells. The first-strand cDNAs were synthesized by using Revertaid first strand cDNA synthesis kit (Fermentas, cat. \# K1621). Gene-specific primers for qRT-PCR were designed by using NCBI Primer-Blast. The quantitative RT-PCR reaction was done with the Maxima SYBR Green/Rox qPCR system (Fermentas, cat. \# K0221).

Identification of Cul3^Klhl12^-substrates {#S17}
-----------------------------------------

To identify Cul3^Klhl12^ substrates, we generated a doxycycline-inducible hKlhl12-3xFLAG stable cell line using the Flp-In™ T-REx™ 293 Cell Line system (Invitrogen). As controls, we generated stable cell lines expressing other BTB proteins including Klhl9. Klhl12-3xFLAG andfor compaction by phase (upper panel) or confocal microscopy (actin, red; vinculin, green; DNA, blue).](nihms347811f2){#F2}

![Cul3^Klhl12^ monoubiquitinates Sec31\
**a.** Immunoprecipitates of ^FLAG^Klhl12 or ^FLAG^Klhl9 were analyzed by Silver staining and mass spectrometry. Asterisk: non-specific band; double asterisk: breakdown product of Klhl12. **b.** Sec13 was immunoprecipitated from HeLa cell lysates, and Sec31 and Klhl12 were detected by immunoblot. **c.** Klhl12 co-localizes with COPII, as seen by confocal microscopy (Klhl12, green; Sec13, red; DNA, blue). **d.** D3 mESCs grown on gelatin and depleted of Sec13 were analyzed for compaction by phase (top) or confocal microscopy (actin, red; vinculin, green; DNA, blue). **e.** Cul3^Klhl12^ monoubiquitinates Sec31. Cul3^Nedd8^-Rbx1 was incubated with Klhl12, Sec13/31, and ubiquitin or ^His^ubiquitin. **f.** *In vitro* ubiquitination of Sec31 by Cul3^Klhl12^ or Cul3^Klhl12-FG289AA^ was performed as above. **g.** Sec31 is


that wogonin did not cause a sedative and myorelaxation effect. Wogonin significantly blocked convulsion induced by pentylenetetrazole and electroshock but not convulsion induced by strychnine. Wogonin also significantly reduced the electrogenic response score, but flumazenil treatment reversed this decrease to the level of the control group. The wogonin treatment increased Cl(-)influx into the intracellular area as dose increased. Flumazenil and bicuculline treatment, however, inhibited the Cl(-) influx induced by wogonin. These results indicate that the anticonvulsive effects produced by wogonin were mediated by the GABAergic neuron.Highly regioselective palladium-catalyzed direct arylation of oxazole at C-2 or C-5 with aryl bromides, chlorides, and triflates.
Complementary palladium-catalyzed methods for direct arylation of oxazole with high regioselectivity (>100:1) at both C-5 and C-2 have been developed for a wide range of aryl and heteroaryl bromides, chlorides, iodides, and triflates. C-5 arylation is preferred in polar solvents with phosphines 5 or 6, whereas C-2 arylation is preferred by nonpolar solvents and phosphine 3. This represents the first general method for C-5 selective arylation of oxazole and should see broad applicability in the synthesis of biologically active molecules. Additionally, potential mechanisms for these two competing arylation processes are proposed on the basis of mechanistic observations.


a pair of sysadmins who were extremely overworked, often
staying back late and working weekends, etc. Eventually they got a meeting
with a higher-up and the opportunity to make their case that they should
probably get raises and hiring another person or two would be a great help.

They didn't get more people to help, but they were told they only had to work
4 days a week instead of 5, so, you know... That's a raise, right? Problem
solved! More money for less hours in the office!

Except for the fact they still had the same amount of work that kept them back
at night on the weekends.

Sysadmin #1 left the meeting, went to his office and wrote his resignation
letter.

Sysadmin #2 went back to his office. He was found a short time later with
slashed wristsfeeling like
the sky is falling every 15 minutes.

Sorry for threadjacking, and thank you all.

~~~
eatitraw
I can't comment on the whole situation, since I live outside of the USA, but I
can give you some advice about Problem #1.

There are great books by David Burns: "Feeling Good: The New Mood Therapy" and
"When Panic Attacks". Both are available at amazon kindle:
<http://amzn.com/0380810336> and <http://amzn.com/076792083X> The "Feeling
Good" book is focused primarily on depression issues and "When Panic Attacs"
(as its name suggest) on various anxiety disorder. I suggest to read them
both. They are really helpful, but not just because of their content(which is
good), but because they present of number techniques from Cognitive-
Behavioural Therapy, which you can apply on yourself. But please note that
reading the book and using these methodics is order of magnitude more
effective than


point you reach where doing _more_ work actually
produces _less_ value. In fact you could draw a graph of working hours vs.
output, and it would rise steadily up to something like 40-50 hours, and then
drop pretty rapidly after that.

I'm learning that not treating everything as urgent, and getting priorities
right and accepting that some things just have to wait ultimately ends up
being the best thing for everyone involved, including customers.

------
motters
This sounds like the final destination of burnout. Probably there should be
more education about the effects of overworking on mental/physical health so
that people can recognise bad situations when they're getting into them and
pull out before it leads to self-destruction. Also the fault is partly on the
management side. A good manager should notice if a particular person seems to
be working a lotreferences for them.

[The Models Involved]{} \[subsection.models.involved\]

[The Massless Nelson Model]{} The massless Nelson model describes the interaction of a system of $N$ non-relativistic nucleons with a quantized, massless meson field. Its Hamiltonian reads as $$\begin{gathered}
H = -\sum_{n = 1}^N\frac{\Delta_n}{2} + \int_{\mathbb{R}^3}\chi_{\Lambda}(k)|k|a_k^{\dagger}a_k\,dk + \sqrt{\alpha}\sum_{n = 1}^N\int_{\mathbb{R}^3}\frac{\chi_{\Lambda}(k)}{\sqrt{|k|}}\left(e^{ikx_n}a_k + e^{-ikx_n}a_k^{\dagger}\right)\,dk,
\label{equation.hamiltonian.nelson.model}\end{gathered}$$ acting on $L^2(\mathbb{R}^{3N})\otimes\mathcal{F}$, where $\mathcal{F}$ is the Fock space on $L^2\left(\mathbb{R}^3\right)$. $a_k$ and $a_k^{\dagger}$ denote the annihiliation and creation operators for the $k$-th mode of the field, respectively, and satisfy the relations $[a_k, a_{k'}^{\dagger}] = \delta\left(k - k'\right)$ and $\left[a_k, a_{k'}\right] = [a_k^{\dagger}, a_{k'}^{\dagger}] = 0$. $\alpha$ is a non-negative number, the coupling constant of the interaction between the nucleons and the meson field; $\Lambda$ is also a non-negative number, and it acts as an ultraviolet cutoff; and $\chi_{\Lambda}$ is the indicator


$\Lambda \to \infty$. However, if one adds a term, that we denote by $Q$ and define as $$\begin{gathered}
\alpha N\int_{\mathbb{R}^3}\frac{\chi_{\Lambda}(k)}{|k|^2\left(|k|/2 + 1\right)}\,dk = 8\pi\alpha N\log\left(1 + \Lambda/2\right),
\label{equation.renormalizing.term}\end{gathered}$$ then one obtains a self-adjoint, bounded below operator $\widehat{H}$ in the limit; more precisely, for every real $t$, $e^{it(H_{\Lambda} + Q_{\Lambda})}$ goes to $e^{it\widehat{H}}$ strongly as $\Lambda$ goes to infinity. The aforementioned properties of were observed by Nelson [@N2]. We would like to mention as well that an additional infrared cutoff $\left\{ k \in \mathbb{R}^3 : |k| \geq \mu\right\}$, on top of $\chi_{\Lambda}(k)$, is required for $H$ to have a ground state [@LMS], even though this fact will not be relevant for us in the present article. We are interested here in the case $N = 2$.

[The Piezoelectric Polaron]{} The piezoelectric polaronartifact; see Section \[section.polaron.nelson\].

The method of proof of the results above involves three ingredients: First, a partition of unity of the configuration space $\mathbb{R}^6$ of the position of the two electrons, which allows local estimates to be made. The partition is an adaptation to the piezolectric bipolaron of an argument of Frank, Lieb, Seiringer, and Thomas [@FLST]. Second, a refined lower bound for the ground-state energy of two particles interacting with each other and with a quantum field through the Nelson interaction (without repelling each other), given in a recent paper of the author [@B], as well as an upper bound for the corresponding 1-particle model, provided in the present article; and third, the observation that the massless Nelson interaction is essentially Coulomb when the interparticle distance is


$\sum_{n = 0}^{\infty}\varphi_n^2(t)$ is equal to 1 for all $t$, and so the functions $\varphi_n$ form a quadratic partition of unity for $[0, \infty)$. We then use the functions $\varphi_n$ to separate the interparticle distance, resulting in a partition of $\mathbb{R}^6$; namely, we consider the functions $\phi_n(x, y) \equiv \varphi_n(|x - y|)$ for $n \geq 0$. And since obviously $\sum_{n = 0}^{\infty}\phi_n^2 = 1$, the collection of functions $\phi_0, \phi_1, \phi_2, \ldots$ forms a quadratic partition of unity for $\mathbb{R}^6$. We then have, by the IMS formula [@CFKS Section 3.1], $$\begin{gathered}
H_A^2 = \sum_{n = 0}^{\infty}\phi_n H_A^2\phi_n - \frac{1}{2}\sum_{n = 0}^{\infty}|\nabla\phi_n|^2,
\label{equation.IMS}\end{gathered}$$ where $H_A^2$ is the Hamiltonian of the piezoelectric bipolaron, Equation . The second term in is a localization error. It tells us that localizing comes at an increaseone of the terms in . We will start with the third one – it can be controlled as follows: by noticing that $|\nabla\phi_n(x, y)|^2 = 2|\varphi_n'(|x - y|)|^2$ for all $n$ and recalling that $\sum_{m = 0}^{\infty}\phi_m^2 = 1$, $$\begin{aligned}
\sum_{n = 0}^{\infty}(\psi, |\nabla\phi_n|^2\psi) & = 2\sum_{n = 0}^{\infty}(\psi, |\varphi_n'(|x - y|)|^2\psi) = 2\sum_{m = 0}^{\infty}\sum_{n = 0}^{\infty}\left(\psi_m, |\varphi_n'(|x - y|)|^2\psi_m\right)\nonumber\\
& \leq \frac{\pi^2}{a_1^2}\|\psi_0\|^2 + \sum_{m = 1}^{\infty}\frac{\pi^2}{\min(a_{m + 1}, a_m)^2}\|\psi_m\|^2.\end{aligned}$$ We now continue with the first term in . This corresponds to the case where the electrons are close to each other. We provide in Appendix B the following lower and upper bounds for the piezoelectric polaron: The ground-state energy of the two-particle piezoelectric polaron without repulsion is bounded below by $-2C_1(\Lambda)\alpha - 8C_2(\Lambda)\alpha^2$, where $C_1$ and $C_2$


T\int_0^{\infty}\frac{dx}{(s_{n - 1} - 2R_n)^2 + x^2} = \frac{8\pi^2\alpha T}{s_{n - 1} - 2R_n},\end{gathered}$$ it follows that, by using the independence of $\mathcal{A}_{1, 1}^T$ and $\mathcal{A}_{2, 2}^T$, is bounded above by $$\begin{gathered}
\exp\left(\frac{8\pi^2\alpha T}{s_{n - 1} - 2R_n}\right)\int\exp\left(\mathcal{A}_{1, 1}^T\right) dW_{x, x}^T\int\exp\left(\mathcal{A}_{2, 2}^T\right) dW_{y, y}^T.\end{gathered}$$ From this and the estimate , we obtain that $$\begin{aligned}
& \left(\psi_{n, u}, H_0\psi_{n, u}\right)\nonumber\\
\geq & \left\{-\lim_{R \to \infty}\lim_{T \to \infty}T^{-1}\log\left[\int_{B_R}\int\exp\left(\mathcal{A}_{1, 1}^T\right)dW_{x, x}^T\,dx\right]\right.\nonumber\\
& \,\,\,\, \left. - \lim_{R \to \infty}\lim_{T \to \infty}T^{-1}\log\left[\int_{B_R}\int\exp\left(\mathcal{A}_{2, 2}^T\right) dW_{y, y}^T\,dy\right] - \frac{8\pi^2\alpha}{s_{n - 1} - 2R_n}\right\}\|\psi_{n, u}\|^2\nonumber\\
= & \left(2E - \frac{8\pi^2\alpha}{s_{n - 1} - 2R_n}\right)\|\psi_{n, u}\|^2,
\label{equation.estimate.second.region}\end{aligned}$$ where, as defined in the previous section, $E$ denotes the ground-state energy of the 1-electron piezoelectric polaron, $\text{inf spec }H^1$. (Right above Equation .) We then conclude, from Equation , $$\begin{gathered}
(\psi_n, H_0\psi_n) \geq \left(2E - \frac{8\pi^2\alpha}{s_{nin [@FLST; @BB], we ought to multiply by $\sqrt{2}$, as in those works the Laplacian was not divided by 2, and by doing so we get a number smaller than 36.7. This is a significant improvement over the previous results of 52.1 [@BB] and 53.2 [@FLST]: a reduction of more than 29.6%.

We would like to remark that the partitions considered here have been indeed fully optimized: one may think, for instance, of taking not bumps in the first partition, but pills (meaning functions that are part sine, part straight line, part cosine); however, it is easy to see that one gets the optimal answer when all the straight-line segments are collapsed into a point, except for the first one. This is why we considered just one pill and


+ x^m - x^n|)|\,ds\,dr \leq \|\varphi\|_{\infty}\int_0^{\Lambda}\!\!\!\int_0^u\frac{re^{-r(u - s)}}{1 + r/2}\,ds\,dr\nonumber\\
\leq & \, \|\varphi\|_{\infty}\int_0^{\Lambda}\frac{dr}{1 + r/2} = 2\|\varphi\|_{\infty}\log(1 + \Lambda/2).\end{aligned}$$ $\mathcal{C}_{m, n}$ is then bounded above by a logarithmically diverging function of $\Lambda$. It follows then from the analysis in [@B Section 2] that the ground-state energy of the piezo-electric polaron is bounded below by $$\begin{aligned}
& -8\pi\alpha N\log(1 + \Lambda/2) - 32\pi^2\alpha^2 N^3\left[\|\varphi(x)/x\|_1 + 4\|\varphi\|_{\infty}\log(1 + \Lambda/2)\right]^2\nonumber\\
\equiv & -C_1(\Lambda)\alpha N - C_2(\Lambda)\alpha^2 N^3.
\label{definition.C1}\end{aligned}$$

An upper bound for the 1-particle piezoelectric polaron, good enough for our purposes here, follows immediately from certain simplifications. First, we note that in the 1-particle case the starting and ending position of the Brownian path $\omega$ does not appear in the action $$\begin{gathered}
\alpha\int\!\!\!\int_0^T\!\!\!\int_0^t\chi_{\Lambda}(k)e^{-|k|(t - s)}e^{-ik(\omega_t - \omega_s)}|k|^{-1}\,ds\,dt\,dk\end{gathered}$$ (see Equation ), due to a cancellation in thepresent article is based partly on that chapter from the thesis, we think it is relevant to resolve the problems here. First, in [@B2 Section 5.1] we localized the six-dimensional vector $(x, y)$, representing the positions of two electrons in 3-space, in the region $\Omega \equiv \left\{(x, y) : |x - y| \geq d\right\}$. This localization should have the effect of keeping the two electrons far from each other; however, this is not what actually happens, at least not if the electrons interact with each other through their coupling to a polar crystal. The point is that the electrons do not attract each other instantaneously; rather, they attract their entire past histories in space, with different weights, with the remote past being less relevant than the recent times.


standings with 41 points, while Chile ended in sixth with 26.
Goalkeeper Claudio Bravo also said he was sorry for Pizzi's decision, and blamed "a lot of situations that will be discussed internally" for Chile's failure to qualify.its Equivalent Box Size

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anxiety, preventing repeat offence”

Ryou spoke simply but Erika couldn’t comprehend.

“Eh, b-but, do you need to go as far as take the money!?”

Ryou mutters towards Erika’s inquiry.

“Game……, isn’t it like in an RPG?”

He answered Erika who didn’t understand the intention.

“Enemy characters in game……, when monsters are defeated don’t they drop money? It’s like that”

Erika cannot hide her surprise as Ryou says his peculiar theory far too indifferently.

“Eh!? But isn’t it only for monsters!?”

Ryou spoke while nodding.

“Ah, monster drop, however in the case of these guys, it appears by feeling around inside their pockets……, on that point isn’t it kind for a monster?”

“Eh!? That!?”

“Besides for enemies there also legitimate humans, for a Boss there are also splendid humans, additionally even bandits drop gold or a treasure chest, don’t you agree?N……? Then, are these guys kinder than bandits?”

Erika watches with a cramp on her mouth while Ryou laughs with an ‘ahaha’, requesting her agreement.

And so Erika decided to observe Ryou again. He has a very plain appearance. Up until today she hadn’t been aware of him in school. She might have caught a glimpse of him but believes that today is the first time seeing him. Such a person spoke without hesitance.

Erika is self-aware that her appearance is superior to most people. The males at school are inquisitive towards her and occasionally send intoxicated sticky glances. When confident men make advances towards her, they usually start to sound desperate and become aware of it. Because such people are often nearby, when ordinary men approach they become excessively nervous,


conscious and run away without talking. However, before her eyes, a truly strange man was seen who could said to be very much outside of common sense.

While Erika is thinking who on earth he was, Ryou finished carrying out similar activity to the two others and spoke to Erika.

“So, how about returning? Does what’s going to happen from here have to be seen?”

Ryou, who was worried about Erika, spoke with his normal tone. Deciding that controlling himself by speaking with a polite and courteous tone was troublesome.

Towards Ryou’s question, Erika was taken aback, worried whether or not to go home. Curiosity towards Ryou started to boil, seeing such a scary event, she shook her neck. Ryou who saw that also shook his neck.

“Haa……, I’m going to wake thesefrightening it seemed to be, resigned himself, and received the beautiful girl’s slap.

Something painful is painful even if received on purpose, staggering lightly afterwards and waiting for the flickering in his eyes to calm down, haa, he sighed.

“My bad……, I was able to help earlier, but didn’t”

Erika who receives Ryou’s apology also returns an apology. Saying sorry though you saved me I glossed over it, again, you saved me, thank you, was once again said.

“The promise……, do you recall?”

“Promise……? Ah, yes, I know ‘not telling anybody what you did to those guys here’ isn’t it? But, is it really fine like this?”

“That is fine……, well then”

Ryou puts his glasses back on while answering, Erika who saw that asked him.

“Why don’t you use contact lenses?”

“This is, my presence……, no,


the crucifix up before her eyes that she might fix her gaze on it when the pain became too much for her to endure. Remember that her last word was ‘JESUS!’
When I’ve watched the video I have of ‘The Passion of Joan of Arc’, I always say, ‘Look at the crucifix!’ at the final scene when the burning takes place.
Legisperitus-I’ve seen “Joan the Woman’, too. Geraldine Farrar plays St. Joan in that one. Was that directed by Cecil B. DeMille, by any chance? I viewed this at the home of a woman in Albuquerque, New Mexico, who has a website dedicated to St. Joan. She has a little museum of Joan of Arc items in a spare room of her house. I nearly cried out at the burning!actually portrayed the Dauphin in our little semi-pro troupe’s production of Shaw’s “Saint Joan.” I saw the 1957 movie a few years later, and was surprised to see that I (with my limited third-rate acting ability) was able to stumble upon the same approach Richard Widmark solidly nailed in his portrayal.

As noted above, Shaw’s play presented all sides of the arguments, in great expository detail (which we had to compress to make the play watchable–and performable for us!), and although Shaw was glad to recast the the struggle over Joan in terms of a secular new-verus-old order perspective (the new “nationalism” as a “secular heresy” to the old feudal model), as well as to portray the Church and its officials as hypocrytical and disbelieving, the possibility of the


defense of the right to life of an innocent and defenseless human being.”

- St. John Paul II

PLEASE RESPOND. Pretty pleeeease?

Should the US Bishops have us return to obligatory "meatless Fridays" during the whole year and not just during Lent?

Because you don’t know when you are going to need to move fast or get along without the supermarket…

Identity theft is a serious problem that you do NOT want to have. I use Lifelock.

And for your cybersecurity…

Wyoming Catholic College!

A great place in Rome…

More food for thought:

“I expect to die in bed, my successor will die in prison and his successor will die a martyr in the public square. His successor will pick up the shards of a ruined society and slowly help rebuild civilization, as the church has done soformazan crystals were dissolved in 150 μL dimethyl sulfoxide (DMSO). The reaction product was quantified by measuring the optical density using test wavelength for 490 nm at room temperature. Every experiment was performed three times and the samples were tested in triplicate.

2.6. Cell Migration Assay {#sec2dot6-genes-07-00083}
-------------------------

Cell migration assays were performed using a transwell permeable supports system (Corning, New York, NY, USA). RKO and HCT116 cells that were under different treatments were incubated in medium. After 24 h of transfection, 2 × 10^4^/well RKO and HCT116 cells were resuspended in serum-free DMEM medium and seeded into the Transwell inserts uncoated with growth factor-reduced Matrigel (BD Biosciences, Bedford, MA, USA), whereas each lower chamber was filled with 500 μL complete culture mediun. After 24 h of incubation at 37 °C,


EZH2, autophagy and apoptosis. Thus, more research should be undertaken to get a better understanding of epigenetic mechanisms and the influence of EZH2 targeted agents on potential survival benefit in CRC patients, which may promote a novel clinical strategy for CRC treatment. Meanwhile, a variety of inhibitors suppress the EZH2 via different mechanisms, such as regulation of other targets or signal pathways, competing toward the SET domain of EZH2 and inducing relevant protein degradation \[[@B43-genes-07-00083],[@B44-genes-07-00083],[@B45-genes-07-00083]\]. All methods of inhibiting EZH2 seem have a potential benefit for treating solid tumors \[[@B45-genes-07-00083],[@B46-genes-07-00083],[@B47-genes-07-00083],[@B48-genes-07-00083]\]. For example, GSK126, an EZH2 competitive inhibitor, is undergoing phase I clinical trials for treating hypermethylation-related cancers \[[@B49-genes-07-00083]\]. However, many studies have also shown that the effect of prior competitive inhibitors is limited, which does not seem torepresent SD (n = 3). (MTT, Methylthiazolyl tetrazolium).](genes-07-00083-g004){#genes-07-00083-f004}

![Depletion of EZH2 by specific shRNA induced autophagy in RKO and HCT116 cells. RKO and HCT116 cells were transfected with control-shRNA or EZH2-shRNA or added 3 μmol/L DZNep for 72 h. Western blot for LC3-II (**a**) as well as Ambra1 (**b**) protein levels are shown. GAPDH levels were monitored to ensure equal loading.](genes-07-00083-g005){#genes-07-00083-f005}

![EZH2-shRNA or DZNep alters apoptosis rate in RKO and HCT116 cells. Cells were transfected with EZH2-shRNA or control-shRNA (**a**,**b**), or added 3 μmol/L DZNep (**c**,**d**), 72 h later, cells were stained with Annexin V and PI, and then analyzed by a flow cytometer.](genes-07-00083-g006){#genes-07-00083-f006}

![EZH2-shRNA or DZNep altered alters cell cycle distribution in RKO cells. Cells were transfected with EZH2-shRNA or control-shRNA, or added 3 μmol/L DZNep, 5 days later, cells


querying the option database for
the window's other options, and it will also be used later for
other purposes such as bindings.
The \fB\-class\fR option may not be changed with the \fBconfigure\fR
widget command.
.OP \-colormap colormap Colormap
Specifies a colormap to use for the window.
The value may be either \fBnew\fR, in which case a new colormap is
created for the window and its children, or the name of another
window (which must be on the same screen and have the same visual
as \fIpathName\fR), in which case the new window will use the colormap
from the specified window.
If the \fB\-colormap\fR option is not specified, the new window
uses the same colormap as its parent.
This option may not be changed with the \fBconfigure\fR
widget command.
.OP \-height height Height
Specifies the desired height for the window in any of the forms
acceptable toRead book online

Linda Robertson. Hallowed Circle

Persephone Alcmedi has been persuaded to compete for the position of High Priestess of the Cleveland, Ohio, coven — now that the former priestess, Vivian Diamond, has strangely gone missing. Unfortunately, there are a few small problems with the idea. Not only does Seph know rather more about Vivian’s disappearance than the other witches realize, but the epic struggle she’s just survived has left her with some highly unusual powers — ones that could be dangerous to reveal. Despite her reluctance, she agrees to participate, if only to prevent snooty Hunter Hopewell, an obnoxious but talented witch, from ending up in the winner’s circle.

Can Seph hide her secrets — including her connection to the master vampire-wizard Menessos — from the terrifyingly wise judges?


Many graphical user interfaces for computers are based on a desktop metaphor that creates a graphical environment simulating work at a desk. These graphical user interfaces typically employ a windowing environment within the desktop. The windowing environment presents the user with specially delineated areas of the screen called windows, each of which is dedicated to a particular application program, file, document, or group of files (e.g., a folder).
FIG. 1 is an illustration of a prior art graphical user interface 10 of a computer network folder 12 containing multiple computer files 14, such as document files, photo files, etc. It will be appreciated that computer files 14 in FIG. 1 are actually icons that represent or designate the files, but in the terminology of the art the icons orthats what its here for f*ck stick.. to respond to it. to discuss it... otherwise the comment section wouldn't exist..

I spend a lot of time on here because Im in the exhibition industry and I like to know all the news, and im a HUGE film fanatic.. and theres no way in hell i can sit in my living room and compare directors careers with my f*cking wife.. are you kidding me?... god that would be a nightmare.. But i CAN come on here and talk to my hearts content about films and media alike... You slandering mink for doing that is slandering every one of us..

Dont be a little bitch man.. how about be a part of the conversation instead.

Yeah, and even though it doesn't really matter,


the overpayments. The court held equitable estoppel precluded this recoupment. Wilson, 85 Wn.2d at 82. The court stated:
the plaintiff properly assumed that the payments tendered to him were accurate and structured his life accordingly. To allow [the employer] to repudiate its original representations and to require the plaintiff to repay the excess payments at this time would be highly inequitable and prejudicial.
Wilson, 85 Wn.2d at 82. Like the respondents in these cases, the plaintiff in Wilson was not substantively eligible for the overpayments. However, this fact did not bar consideration of whether equitable estoppel applied under the facts of that case.
DSHS maintains Wilson does not apply because estoppel was sought in that case against a private party, not the government. However, the "injury" element applies under Washington lawdebt without drawing on funds currently needed to meet their most basic needs; (2) the respondents provided DSHS with timely and accurate *749 information, and the overpayments resulted solely from the Department's error; (3) the overpayments involved a continuation of benefits for which the respondents had been eligible, and there was no reason they would have been alerted to the fact of overpayment; and (4) there was no evidence the respondents were abusing the public assistance system. Kramarevcky, 64 Wn. App. at 23-24. These factors establish the "manifest injustice" element has been met in these cases.
DSHS also argues the Court of Appeals erred in determining that application of estoppel in these two cases will not impair governmental functions. The Court of Appeals observed the overpayments in this case


vires doctrine, however, reveals that the Superior Court's ruling was in error.
In Regents, the Attorney General for the State failed to appear at a condemnation proceeding brought in 1906 by the City of Seattle and the court entered a default judgment in favor of the city. Regents, at 547. Some 80 years later, the State argued it was "not bound to the acts of the Attorney General in the 1906 litigation" because those acts were "ultra vires". Regents, at 552. The court distinguished between irregular acts within an agency's authority and ultra vires acts wholly without authority. It reasoned that, although the State was not bound by ultra vires acts, "[a]n act of an officer which is within his realm of power, albeit imprudent or violative of anot lose sight of the distinction which exists between acts which are absolutely ultra vires by reason of the corporation having no authority to act on the subject-matter  it being wholly beyond the scope of its powers  and those acts which in a sense are termed ultra vires, where the body has jurisdiction of the subject-matter, but, in the execution of its authority, trespasses upon the rights of others.
Wendel, at 124. Since the construction of the road was clearly within the authority of the county, and the county could have constructed the road without complication had it been more careful, the county could not defend itself under the ultra vires exception. Wendel, at 124.
The distinction in Wendel was reiterated in Haslund. In Haslund, a developer brought


& $8.28 \; (0.87)^{***}$ \\
dist        & $0.17 \; (0.02)^{***}$ \\
\hline
R$^2$       & $0.65$                 \\
Adj. R$^2$  & $0.64$                 \\
Num. obs.   & $50$                   \\
\hline
\end{tabular}
\begin{tablenotes}[flushleft]
\scriptsize{\item $^{***}p<0.001$; $^{**}p<0.01$; $^{*}p<0.05$. This regression should be interpreted with strong caution as it is likely plagued by extensive omitted variable bias}
\end{tablenotes}
\end{threeparttable}
\caption{Statistical models}
\label{table:coefficients}
\end{center}
\end{table}

Which is rendered as:

Note that the custom note must start with \\item. It is also possible to have multiple items                  "extensive omitted variable bias."),
       single.row = TRUE,
       threeparttable = TRUE)

The formatting is not perfect as you cannot set the desired width of the table; the note just adjusts to the width of the respective table. But I think it should be less of a problem in a realistic usage scenario where more than one model is displayed at a time and some of the coefficient names are longer than in the example. This solution also supports longtable environments, in which case the threeparttablex package is used instead.
Here is an example of how you could make it look nice


that \r\n is considered a grapheme cluster
		// and so we don't need to worry about miscounting additional lines
		// on files with Windows-style line endings.
		if len(gr) != 0 && (gr[0] == '\r' || gr[0] == '\n') {
			new.Column = 1
			new.Line++
		}

		if advanced < len(token) {
			// If we've not yet found the end of our token then we'll
			// also push our "end" marker along.
			// (if advance > len(token) then we'll stop moving "end" early
			// so that the caller only sees the range covered by token.)
			end = new
		}
		advanced += len(gr)
	}

	sc.cur = Range{
		Filename: sc.filename,
		Start:    start,
		End:      end,
	}
	sc.pos = new
	return true
}

// Range returns a range that covers the latest token obtained after a call
// to Scan returns true.
func (sc *RangeScanner) Range() Range {
	return sc.cur
}

// Bytes returns the slice                              Plaintiff - Appellant,

          versus

ATTORNEY GENERAL’S OFFICE; JUDGE KULP, Henrico
County   Court;   COMMONWEALTH’S    ATTORNEY’S
OFFICE, of Virginia,

                                            Defendants - Appellees.

Appeal from the United States District Court for the Eastern
District of Virginia, at Richmond. Robert E. Payne, District Judge.
(CA-02-98)

Submitted:   June 20,


to the igniter for the cylinder under control. However, in order to prevent fuel wastage as well as discharge of unburned fuel mixture into the atmosphere, it is preferred to adopt a torque control which is based on the cut-off or interruption of the fuel injection.
FIG. 7 is a block diagram showing a conventional control apparatus designed, for example, for a four-cylinder internal combustion engine in which the fuel supply to the engine is realized through fuel injection and the ignition control is realized by distributing a high voltage to spark plugs of the individual cylinders, respectively. Referring to the figure, an angular position signal generating means 1 is provided in association with a rotatable shaft of the engine, such as a crank shaft, cam shaft or thelike. The generating means 1 generates an angular position signal T at every predetermined reference angular position of the crank shaft as the engine operates. To this end, the angular position signal generating means 1 may be constituted by an electromagnetic pick-up device disposed in opposition to a disk mounted on the crank shaft or cam shaft for rotation therewith and having a projection formed in the periphery of the disk, which projection passes by the electromagnetic pick-up device as the crank or cam shaft rotates. Alternately, the angular position signal generating means 1 may be implemented in the form of a photoarray disposed in opposition to slits formed in the disk mentioned above. In any case, the angular position signal T contains the reference position information for


4 via the input interface 41. The various sensors 2 detect the engine operation states, whereby the engine operation state signal D is inputted to the ignition control unit 44 of the control means 4 via the input interface 42.
The fuel control unit 43 detects the reference position for each cylinder on the basis of the angular position signal T and arithmetically determines the fuel injection quantity as well as the fuel injection timing on the basis of the engine operation state signal D to thereby generate the fuel injection signal J corresponding to the calculated fuel injection quantity. Signal J is applied to the fuel injector 5 via the output interface 45. On the other hand, the ignition control unit 44 detects the reference position for eachalong with her fellow Medmenham colleague, Sqn Ldr Peter Riddell.

Working on the interpretation of aerial reconnaissance photographs, Constance was credited with the discovery of the V1 at Peenemunde, Germany.

In 1942, Babington Smith was Mentioned in Dispatches for her work and in 1945 she was awarded the MBE.
Her brother, Bernard, was also honoured for his work at the CIU, receiving the OBE.

She was portrayed in the 1965 film Operation Crossbow by Sylvia Syms.

After VE-Day Constance was attached to USAAF Intelligence in Washington, D.C. to continue her work on photographic interpretation, this time for the Pacific theatre.

In 1946, the United States awarded her the Legion of Merit.

Later life
From 1946 to 1950 she was a researcher for Life Magazine.  She later moved to Cambridge, Britain, where she converted to Greek


$X$ meson pole (\[fpluspolo\]). The branching ratio is therefore calculated dividing the result by the total width of the $B$ meson $\Gamma_{\mathrm{tot}}=\hbar/\tau_B$: $$\lb{result}
  \mathcal{B}(B\to X(3872)K)=(1.00\pm0.68)\times10^{-5}\,,$$ where we have used the mean life of the $B$ meson $\tau_B=1.638\times10^{-12}$ s, the CKM parameters $V_{cs}=1.023$, $V_{cb}=40.6\times10^{-3}$ [@pdg], and the Wilson coefficients $C_1(\mu)=1.082$, $C_2(\mu)=-0.185$, computed at $\mu=m_b$ and $\bar{\Lambda}_{\mathrm{MS}}=225\MeV$ [@buras]. The result (\[result\]) is in agreement with the experimental upper limit (\[branching\]).

For completeness we also compute the branching ratio for the $X$ as pure $\bar{c}c$ and molecular states. We choose the mixing angle as $\theta=90^\circ$ and $\theta=0^\circ$ in Eq. (\[field\]), and we get respectively for the pure molecule and pure charmonium: $$\lb{resmol}
  {\mathcal{B}}(B\to X_{\mathrm{mol}}K)=(0.38\pm0.06)\times10^{-6}\,,$$ $$\lb{resccbar}
  {\mathcal{B}}(B\to X_{\bar{c}c}K)=(2.68\pm0.50)\times10^{-5}\,.$$ Comparing the results for the pure states with theto endure. Prayer became a hollow exercise. She searched her life for unconfessed sin and confessed it all. Worship meant talking with congregants after the service which took all her effort. She cried as she spoke. She tried everything her friends recommended; get out more, pray more, study the Bible more, exercise, take the latest nutriceutical, eat organic and even, "snap out of it." Nothing helped. I prescribed an anti-depressant for her.

Depression is the word in the church that must not be spoken. Those taking anti-depressants may find themselves stigmatized by pastors, elders or church members. I've had patients forbidden by husbands and elders from taking medicine for serious depression. I've had many Christian women take anti-depressants secretly, fearing the backlash waiting them should the church or their


EU Bickering Pauses for Nobel

Leaders Tout Past Achievements, but Struggle to Lay Out a Detailed Vision of the Future

ENLARGE

The European Union was awarded the Nobel Peace Prize on Monday at a ceremony in front of some 950 people at Oslo's city hall.
European Pressphoto Agency

By

Gabriele Steinhauser and

Kjetil Malkenes Hovland

Updated Dec. 10, 2012 7:28 p.m. ET

OSLO—The often fractious leaders of Europe took a break from constant questions about how to resolve their debt troubles Monday to celebrate their relative peace.

For a few hours, most of the leaders of a continent once racked by war joined to accept this year's Nobel Peace Prize amid grand ceremony, more than three years into an economic crisis that has plunged much of the continent into recession and stoked tensions among many of Europe's memberrapid integration of former Soviet-bloc states in Eastern Europe.

But Mr. Van Rompuy acknowledged that those memories were fading. "Parents struggling to make ends meet, workers recently laid off, students who fear that, however hard they try, they won't get their first job," he said. "When they think about Europe, peace is not the first thing that comes to mind.

"War has become inconceivable," he added. "Yet inconceivable does not mean impossible."

Some in Norway and farther afield argued that the award shouldn't have been made while Brussels is promoting austerity in some of Europe's most indebted states—especially Greece, Spain and Portugal—in response to the crisis.

An odd coalition of roughly 300 international peace activists and Norwegian political parties set on keeping their country outside the EU protested the award Sunday. "How


A translational case study of empowerment into practice: A realist evaluation of a member-led dementia empowerment service.
Involving people with dementia in decision-making is widely accepted as a means of empowering them to lead more independent lives and have more meaningful roles in shaping their care. However, there is a need to conduct rigorous evaluations of empowerment-driven services and policies in order to develop a deeper understanding about how to optimise successful implementation. This paper presents the results of an evaluation of Dementia Northern Ireland, an organisation initiated and led by people with dementia. We used a realist evaluation approach that comprised interviews with 15 people with dementia, three staff and two board members, ethnographic observations, along with documentary analysis to identify 'what works, for whom, under what circumstances'.Oil Holds Steady in New York on U.S. Budget Deadlock

By Mark Shenk -
Dec 24, 2012

Oil was little changed in New York
amid concern that U.S. lawmakers will miss a year-end budget
deadline, threatening to weaken the American economy.

Futures traded in a 66-cent-a-barrel range as Democrats and
Republicans discussed how to avoid more than $600 billion in tax
gains and spending cuts, known as the fiscal cliff, which are
scheduled to take effect Jan. 1. Failure to reach agreement
would push the U.S. into recession for the first half of 2013,
the nonpartisan Congressional Budget Office said.

“It looks like there may be a series of small deals,”
said Bill O’Grady, chief market strategist at Confluence
Investment Management in St. Louis, which oversees $1.4 billion.
“It may end up being more of a fiscal slope than a cliff.”

Crude oil for


The sweetness enhancers used herein are known as natural and artificial sweeteners, however, they are used herein in a much lower concentration near their sweetness detection threshold.
These sweetness enhancers include Naringin dihydrochalcone (NarDHC), mogroside V or swingle extract comprising mogroside V, rubusoside or rubus extract comprising rubusoside, stevioside, and rebaudioside A.
Naringin dihydrochalcone has been used as a sweetener in concentrations well above its sweetness detection level. It has also been used in combination with stevioside to reduce the off-note of stevioside (JP10276712).
Swingle (also known as Lou Han Gou (LHG)) contains various naturally-derived terpene glycosides, in particular various mogrosides including mogroside IV, mogroside V, siamenoside I, and 11-oxo mogroside V. A swingle/LHG juice based sweetening system that provides a reduced sweet or unpleasant aftertaste is disclosed in U.S. Pat.Trends in Medicare Reimbursement for Orthopedic Procedures: 2000 to 2016.
Understanding trends in reimbursement is critical to the financial sustainability of orthopedic practices. Little research has examined physician fee trends over time for orthopedic procedures. This study evaluated trends in Medicare reimbursements for orthopedic surgical procedures. The Medicare Physician Fee Schedule was examined for Current Procedural Terminology code values for the most common orthopedic and nonorthopedic procedures between 2000 and 2016. Prices were adjusted for inflation to 2016-dollar values. To assess mean growth rate for each procedure and subspecialty, compound annual growth rates were calculated. Year-to-year dollar amount changes were calculated for each procedure and subspecialty. Reimbursement trends for individual procedures and across subspecialties were compared. Between 2000 and 2016, annual reimbursements decreased for all orthopedic procedures examined except


system, consequently overriding Jo’s eligibility status. The Advocate helped Jo get this mistake fixed, and her Medicaid was reinstated. “If it weren't for the dedicated Community Health Advocates (CHA) team, I might still be without medical care.” Now Jo does not have to worry about accessing the lifesaving care she needs, and can focus on acting and staying healthy. “[CHA’s] dedication and persistence paid off, and I'm happy to say I now have excellent, consistent coverage. I owe it all to my friends at CHA!”

“Sometimes you simply need a helping hand, and CHA certainly held my hand along my arduous journey through the healthcare world.” -- JoFrançois Isaac de Rivaz

François Isaac de Rivaz (Paris, December 19, 1752 – Sion, July 30, 1828) was an inventor and a politician. He invented a hydrogen-powered internal combustion engine with electric ignition and described it in a French patent published in 1807. In 1808 he fitted it into a primitive working vehicle – "the world's first internal combustion powered automobile".

Biography
Isaac was born in Paris to a family from Valais. In 1763 the family settled in Moûtiers in Savoy (Kingdom of Sardinia). The last two boys, Anne Joseph and Isaac, came to settle in St. Gingolph in Valais. It is not known at which schools he studied, but he became fluent in Latin plus mastering mathematics and geometry, whilst continuing his study of mechanics throughout his life. He


enterntainment can it be turn off by the main person on the account?

The entertainment only works if enabled by the main line on the account.

Rember the Golden Rule: Treat others how you would like to be treated.

Just because my answer does not solve your issue (or agree with you), it may still be correct information...

Stating a fact about how something works, is NOT taking sides, it's just stating a fact...

Information provided might not be for "you" only, it might be clarification for other community members.

This is the public AT&T Community Forum (not AT&T support), please do not post personal info.

When provided an answer, please click "Accept solution" which helps other people to find an answer more quickly.

The (very) fine print - This footer is at the bottom ofchanged the plan? It goes from 80 to 90 even though it clearly states both plans are the same price!

That's NOT what 'bait and switch' means. If they're lying about the price, it's just called "lying" (not 'bait and switch')

Everywhere it says $80 it says including 'autopay/paperless discount'.

This image that YOU uploaded says $90 and then right under it says 'autopay/paperless discount is pending'.

Rember the Golden Rule: Treat others how you would like to be treated.

Just because my answer does not solve your issue (or agree with you), it may still be correct information...

Stating a fact about how something works, is NOT taking sides, it's just stating a fact...

Information provided might not be for "you" only, it might be clarification for other community members.

This is the public AT&T


Community Forum (not AT&T support), please do not post personal info.

When provided an answer, please click "Accept solution" which helps other people to find an answer more quickly.

The (very) fine print - This footer is at the bottom of all my posts, its particulars may, or may not, apply to you & your post.

Award for Community Excellence 2019 Achiever**The views and opinions expressed on this forum are purely my own. Any product claim, statistic, quote, or other representation about a product or service should be verified with the manufacturer, provider, or party.

Re: AT&T Unlimited & More Plans – Get The Scoop!

What's the point of this if we already have television service through AT&T/DirecTV? Do we not have access to our television service for free through an app already?dilated fistula. In all 4 cases, operations were performed using cardiopulmonary bypass and retrograde coronary perfusion, which could afford good heart protection even in cases with coronary lesions and coronary steal phenomenon. All cases went an uneventful postoperative course. Postoperative angiograms showed disappearance of the fistulas in 3 cases. In one case, however, residual fistula was found because a fine fistula might be overlooked. In such a case with complicated fistulas with aneurysmal enlargement, fistulas should be examined carefully through incision of the enlarged anomalous vessels. In this paper, diagnosis, operative indication and treatment for coronary artery-pulmonary artery fistula were discussed.


= entity.getContent();
    String path = "/storage/emulated/0/YOURAPPFOLDER/FILENAME.EXTENSION";
    FileOutputStream output = new FileOutputStream(path);
    int bufferSize = 1024;
    byte[] buffer = new byte[bufferSize];
    int len = 0;
    while ((len = instream.read(buffer)) != -1) {
        output.write(buffer, 0, len);
    }
    output.close();
}

Instead of saving the file to disk, we can have the contents in the bytearray and get the bitmap from that.
ByteArrayOutputStream baos = new ByteArrayOutputStream();
int bufferSize = 1024;
byte[] buffer = new byte[bufferSize];
int len = 0;
try {
    // instream is content got from httpentity.getContent()
    while ((len = instream.read(buffer)) != -1) {
    baos.write(buffer, 0, len);
that the Lord continues to bless you and your work and that your chocolate cup flows over in abundance! ^_^
Kasey~

Kasey-
Oh YAY I’m glad! That seriously made me SO happy to read that 😀
Cake Batter Oatmeal just makes life wayyy better 😉
Thank you so much for being so kind. I wish you all the best in your bodybuilding and competitions!
-Jess

I love cake batter flavored things. Unfortunately, they are usually filled with crap… and that’s definitely not what I am looking for. So I am sooo excited to find your healthier cake battery option, that’s for breakfast!! WINNNNNER!

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Welcome to Desserts With Benefits®!


its origins in cultural difference – rather than the sort of fear, distress, humiliation or victimisation that one would ordinarily expect in a bullying scenario".

Flatulence not 'intimidation'

The judge rejected claims about the frequency of the supervisor's flatulence or that it was targeted at Mr Hingst.

She said even if the claims were true, it would not necessarily amount to bullying.

"It is difficult to see how Mr Short's conduct could have intimidated or caused distress to the [administrator]," the judge said.

"[Mr Hingst] was able to spray Mr Short with deodorant and give him the nickname 'Mr Stinky'. Indeed, on [his] own evidence, had he not lost his job and been abused over the telephone, the flatulence would 'never have been a big issue'."

On allegations Mr Short yelled at Mr Hingstelection bears more resemblance to the 2016 presidential election in terms of turnout than the 2014 midterms, according to Coweta Elections Superintendent Jane Scoggins. In 2014, a popular incumbent governor was on the ballot, while this year there is a fiercely contested and nationally watched governor’s race.

Total early voting turnout in 2016 was 31,439, with 3,112 absentee ballots, according to Scoggins.

Scoggins thinks Coweta might reach or beat that turnout this year. Typically, early voting starts off slow and turnout grows over time.

“I expect it to stay busy. And we’re ready,” Scoggins said.

Scoggins said she’s gotten quite a few phone calls from people who think something is wrong with their absentee ballot because there is no race for Coweta Sheriff on it.

There are several candidates campaigning to succeed Sheriff


"Microsoft.Extensions.DependencyInjection": "3.0.0"
        },
        "runtime": {
          "Prise.Plugin.dll": {}
        }
      },
      "Prise.PluginBridge/1.0.0": {
        "runtime": {
          "Prise.PluginBridge.net3.dll": {}
        }
      }
    }
  },
  "libraries": {
    "PluginG/1.0.0": {
      "type": "project",
      "serviceable": false,
      "sha512": ""
    },
    "Microsoft.Extensions.Configuration.Abstractions/3.0.0": }
    else {
      __oi = __fill_n(__oi, __pad, __fill);
      return copy(__first, __last, __oi);
    }
  }
}

#if !defined (_STLP_NO_WCHAR_T)
// Helper routine for wchar_t
template <class _OutputIter>
_OutputIter  _STLP_CALL
__put_float(__iostring &__str, _OutputIter __oi,
            ios_base& __f, wchar_t __fill,
            wchar_t __decimal_point, wchar_t __sep,
            size_t __group_pos, const string& __grouping) {
  const ctype<wchar_t>& __ct = *__STATIC_CAST(const ctype<wchar_t>*, __f._M_ctype_facet());

  __iowstring __wbuf;
  __convert_float_buffer(__str, __wbuf, __ct, __decimal_point);

  if (!__grouping.empty()) {
    __insert_grouping(__wbuf, __group_pos, __grouping,


                              __STATIC_CAST(streamsize, __wid - __len)));
    ios_base::fmtflags __dir = __flg & ios_base::adjustfield;

    if (__dir == ios_base::left) {
      __oi = copy(__buf, __buf + __len, __oi);
      return __fill_n(__oi, __pad, __fill);
    }
    else if (__dir == ios_base::internal && __len != 0 &&
             (__buf[0] == __xplus || __buf[0] == __xminus)) {
      *__oi++ = __buf[0];
      __oi = __fill_n(__oi, __pad, __fill);
     *--__ptr = __table_ptr[16];
            *--__ptr = '0';
          }
        }
        break;
      //case ios_base::dec:
      default:
        {
#if defined(__HP_aCC) && (__HP_aCC == 1)
          bool _IsSigned = !((_Integer)-1 > 0);
          if (_IsSigned)
            __ptr = __write_decimal_backward(__ptr, __x, __flags, __true_type() );
          else


have the time field (i.e. it is not null) and where the type is NOT a date and then group per user per day using the $dateToString operator which produces a formatted date time string that will represent the day.
Run the following aggregate operation to get the count of posts per day
db.collection.aggregate([
    { "$match": { "time": { "$exists": true, "$not": { "$type": 9 } } } },
    {
        "$group": {
            "_id": {
                "$dateToString": {
              Ibrutinib has the following structure, with a chemical name of 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

Ibrutinib is the first in class of an oral Bruton's tyrosine kinase (BTK) inhibitor for the treatment of chronic lymphocytic leukemia (CLL) and is one of the first medicines to file for FDA approval via the new Breakthrough Therapy Designation pathway. Ibrutinib forms a covalent bond with a cysteine residue (Cys-481), leading to irreversible inhibition of BTK, thus effectively blocking the transfer of cancer cell from B-cell to lymphoid tissue where is benefit for the growth of tumor.
The intermediate compound having the following structure is employed to synthesize ibrutinib.

The compound of formula VI can be used to produce ibrutinib according to the method disclosed in America U.S. Pat. No. 7,514,444, and its synthesis route is depicted as below:

The


Association of the serotonin transporter promoter polymorphism with smoking behavior among adolescents.
Serotonin transporter promoter polymorphism (5-HTTLPR) genotype was previously found associated with smoking behavior, difficulty in quitting smoking, and nicotine addiction; with non-replicated findings and contrasting results. Aim of the present study was to evaluate the possible association between 5-HTTLPR genotype and smoking behavior among adolescents, in relationship with psychological characteristics. Two hundred and ten Caucasian high school students (aged 14-19 years); 103 non-smokers, who have never smoked nicotine; and 107 tobacco smokers have been genotyped. Aggressiveness levels and temperamental traits were measured in both smokers and non-smokers, respectively, utilizing Buss-Durkee Hostility Inventory (BDHI) and Cloninger Three-Dimensional Personality Questionnaire (TPQ). Data about school performance have been also collected. The short-short (SS) genotype frequency was significantly higher among smokersonly for three terminal currents and charges and allow computation of the current and charge of the fourth terminal so that total charge and current ate zero. Unfortunately, these simplifications are not enough to make transistor models sufficiently efficient. Therefore, fast transient circuit simulators often use additional approximations for simplifying a transistor table model. For bulk MOS transistors, it is common to assume that transistor terminal capacitances are linear, meaning that they do not depend on transistor terminal voltages. This assumption permits using just average values of transistor terminal capacitances instead of a table of terminal charges as functions of terminal voltages. Currents of bulk MOS transistor table models can be simplified by ignoring substrate and gate currents as they are orders of magnitude less than transistor channel


terminal is a VLSI substrate that is permanently connected to ground or a supply voltage VDD. The counterpart terminal in an SOI transistor is a body that has very small capacitance and usually is not connected to any other circuit node. Because of that, the body potential (voltage) varies significantly during circuit operation due to such effects like capacitive coupling with other circuit nodes, leakage, and impact ionization currents. These effects significantly influence SOI transistor behavior by changing its threshold voltage.
Another complication with the SOI transistor model arises due to its usage with different types of body connections. The most common case, and also the most difficult to simulate, is the floating body configuration wherein the transistor body is not connected to any other circuit node. The floatingwas always a heuristic. In many situations it might show a hyperlink unnecessarily or omit one that would have been useful.

Integrating Hyperlinks

With recent versions of VTE this is now done properly, without needing a heuristic!

Here’s what it might look like:

the ls program can automatically add relevant links

All this magic works because programs can include magic “escape codes” which tell the shell to do special things. They have been traditionally used to add colours or underlining to shell output. In this case they’re been used to send a special message telling the shell that it might want to hyperlink something.

The venerable ls program was updated to include a --hyperlink option, which, when active produces the above output. If you look closely, it puts a fine line of dots over


to more of the terminal apps out there. Imagine having a git log with clickable sha1 hashes, or pasted irssi links which shorten and ellipsize, but which are still clickable? All of these things are possible, so start getting those patches upstream!

Advanced Use Cases

I started to think about if some fancier use cases were possible. Imagine if running an ls command over ssh could have the hyperlink information modified by the local shell so that it knew it was a remote URL. In that case, the terminal might consider converting it to a gvfs link instead, giving you easy access to remote files.

It might be fun thinking about if adding hyperlinks to vim could offer links to full screen help dialogs. An even fancier idea might be toQ:

Learning functional programming after other programming paradigms

I have taught myself C, Python, Java and a few other procedural or object oriented languages to an intermediate degree from resouces on the internet (thanks SO :D) and in books. When I tried to learn Haskell, I couldn't wrap my head around what the code actually did.
Is there a better functional language for someone coming from a background in procedural or object oriented programming to learn? Are there any resources meant for people in my situation?
Thanks!

A:

It's probably varies with people (and this question is bound to get closed over that), but the way I see it: there isn't a stair you need to step on before you can be within reach to Haskell.
So I'd say you're not driven temporarily


fashions and other radical products on WWEShop.com®!

So if you feel like I do, why not use the hashtags #FourHourRaw and #ThankYouVince on social media, and perhaps WWE executives will listen to us fans, the way they always do!

Perhaps, if we’re lucky, SmackDown LIVE® will get longer too!

Sure, I’m just a fan like each and every one of you, but make no mistake about it — together we can make our voices heard, quite frankly.

– Vance Kenneth MacManus

Quite frankly, you need to subscribe to our YouTube Channel, quite franklyEthics Commission. For the Senate, a half dozen races appear to have most consistently attracted the parties’ attention in recent weeks. The list of House races is considerably longer.

By this point in 2010, the parties hadn’t even started spending their funds on mail pieces specifically supporting or opposing the election of legislative candidates. At this point in 2008, the state’s Democratic party had spent only $4,700 on a mail piece supporting a single Senate candidate, according to Ethics Commission records.

Story continues below advertisement.

“To me, the conclusion one can draw based on the level of spending so far is that everybody recognizes that control of both chambers is up for grabs and that it’s going to be a close election,” said Josh Tardy, a former House Republican leader who


Hemodynamic and morphologic evaluation of sequelae of primary upper extremity deep venous thromboses treated with anticoagulation.
This study was performed to describe venous function, residual morphologic abnormalities, and the occurrence of post-thrombotic syndrome in patients with conservatively treated primary upper-extremity deep venous thromboses (UEDVT). This was a retrospective follow-up study of 31 patients with previous primary UEDVT treated with anticoagulation only, identified by a search of medical records. The mean follow-up time was 5 years. The patients were evaluated by interview, clinical examination, computerized strain-gauge plethysmography, and color duplex ultrasound imaging. The grade of post-thrombotic syndrome was rated according to the Villalta score (0 to 3 on each of four subjective and five clinically assessed features). The rate of venous emptying was significantly lower in the arms with DVTsthan in the contralateral arms (P < .001). Eleven of the patients (35%) had a remaining outflow obstruction in the affected arm (venous emptying <68 mL/100 mL per min). Eighteen (58%) had a residual thrombus according to color duplex ultrasound scans, with four remaining occluded subclavian veins. None of the patients had deep or superficial venous reflux. There was no statistically significant relationship between plethysmographic and duplex findings. Most (77%) of the patients reported remaining symptoms in the affected arm, and there was a significant side difference in upper arm circumference (P < .001). Approximately one third had developed a moderate grade of post-thrombotic syndrome according to the Villalta score (total, 5 to 9). No significant relation was evident between the post-thrombotic syndrome score and duplex findings. Patients


a room in which marijuana was found; (4) That certain evidence was obtained by illegal search and seizure; and (5) That the trial court erred in excluding certain hotel records.
 Appellant contends that the trial court unduly restricted counsel in his cross-examination of prosecution witnesses Hector Reyna and Major McBee. It is argued by the appellant that the cross-examination of Reyna was unduly restricted by the trial court in that counsel was not permitted to test the witness' recollection and credibility.
 [1] Mr. Reyna testified on direct examination that he was employed by the State Bureau of Narcotic Enforcement on September 28, 1957. He came to Vallejo for the purpose of making purchases of narcotics and was given a list of places where he could make a connection.and discovered that the appellant was registered in room 12; they further ascertained from the landlady that the defendant was the only one living in the room, and with the assistance of the landlady they entered the room and searched and discovered the marijuana cigarettes. The appellant was seen entering the Manx Hotel just before his arrest.
 However, the record shows that there was no objection by counsel for the appellant to the introduction of any of this evidence relating to Count IV charging possession of narcotics. In fact, counsel for the appellant not only failed to object, but much of the testimony on this point was brought out on cross-examination by appellant's counsel. [9] It is a general principle of law, well established in this state, that


Background {#Sec1}
==========

Rectal cancer (RC) is one of the most common malignancies in the USA, and the incidence of RC in Asian countries is increasing rapidly and has been considered to be similar to that of the Western countries \[[@CR1]\]. Preoperative radiotherapy (Pre-RT) has become part of standard practice offered to improve treatment outcomes in patients with RC because of the oncologic benefit of reduced local recurrence rate \[[@CR2]\]. But till now, there is still lack of effective means for accurate prognostic evaluation on the survival.

It is widely thought that lymph node (LN) metastasis indicates worse tumor response grade and poorer survival. According to the guidelines for RC from the National Comprehensive Cancer Network, a minimum of twelve lymph nodes must be retrieved and examined for accurate staging andNLN count was an independent prognostic factor for patients with RC who received Pre-RT. It could provide more accurate prognostic information for RC patients with Pre-RT (stage ypI, ypII and ypIII, respectively).

LN

:   Lymph node

NLN

:   Negative lymph node

Pre-RT

:   Preoperative radiotherapy

RC

:   Rectal cancer

SEER

:   Surveillance, Epidemiology, and End Results Program

The authors acknowledged the efforts of the Surveillance, Epidemiology, and End Results (SEER) Program tumor registries in the creation of the SEER database. The interpretation and reporting of these data were the sole responsibility of the authors.

Funding {#FPar1}
=======

The design of the study and collection, analysis, and interpretation of data were supported by National Natural Science Foundation of China to Xinxing Li (Grant No. 81402002).

Availability of data and materials {#FPar2}
==================================

The cohort data are


are dependent on C activation, such as the protective effect against *Candida albicans* infections and the pathogenicity in hemolytic anemia ([@bib6], [@bib7]). Another possible effector pathway of IgG3 is via Fc-receptors (FcRs).[\*](#fn1){ref-type="fn"} Early studies demonstrated that macrophages could phagocytose IgG3-coated particles and suggested the existence of a specific FcR for IgG3 ([@bib8]). This receptor has been elusive, and for many years IgG3 was not believed to bind to any of the known murine Fc-receptors for IgG (FcγRI, FcγRIIB, or FcγRIII; reference [@bib9]). However, recent data suggest that FcγRI is the IgG3-binding receptor ([@bib10], [@bib11]).

Apart from mediating various effector functions, Abs have the ability to feedback regulate the production of themselves (for a review, see reference [@bib12]). Passively administered, or actively produced, specific Ab can enhance or suppress Abreduced in C3-depleted as well as in Cr2^−/−^ mice, suggesting that IgG3, in analogy with IgM, enhances the Ab response via the C system.

Materials and Methods
=====================

Antigens.
---------

BSA (fraction V, A-3059), OVA (grade V, A-5553), and TNP (picrylsulfonic acid/hydrate) were from Sigma-Aldrich and KLH from Calbiochem. TNP was conjugated to BSA or OVA as described ([@bib28]). The number of TNP residues/Ag molecule was 12 for BSA and 3 for OVA determined according to ([@bib29]). SRBC from the National Veterinary Institute (Uppsala, Sweden), were conjugated to TNP (SRBC-TNP) as described ([@bib30]).

Antibodies.
-----------

5-mo-old BALB/c mice (Bommice) were immunized in the tail vein with 4 × 10^8^ SRBC-TNP in 0.1 ml PBS. 3 d before the fusion, mice were boosted intravenously with 4 × 10^8^ SRBC-TNP and 10 μg LPS (Sigma-Aldrich) intraperitoneally. Splenocytes were


several abnormalities in their immune system, secondary to the lack of secretory IgM, and were also reported to have developmental defects in their B cell compartment ([@bib45], [@bib47]). The underlying reason for the impaired IgG responses observed ([@bib44]--[@bib46]) is not known. However, one intriguing explanation would be that "natural" IgM, present without prior (deliberate) immunizations, initiates positive feedback of early responses. Should the enhancing effect of natural IgM be caused by its ability to activate C, which has not been formally proven, it is possible that recognition of Ag by natural IgM is the first step in the C-dependent chain of events leading to efficient early Ab responses to suboptimal doses of Ag. This would explain how classical C activation can play a role already for primary AbI'M E-MAILING THIS TO MYSELF NOW," "AND WE'RE GONNA CIRCULATE THIS" "TO ALL OF THE LOCAL LAW-ENFORCEMENT AGENCIES." "ANY KNOWN MEDICAL ISSUES?" "HE'S A LITTLE COLICKY." "OKAY." "AND WHO ELSE LIVES IN THE HOUSE?" "JUST ME AND OWEN." "AND THE BABY'S FATHER?" "HIS NAME'S ANDREW O'LEARY." "AND HAVE YOU BEEN IN CONTACT SINCE OWEN'S DISAPPEARANCE?" "I'M NOT SURE HOW TO GET AHOLD OF HIM." "HE'S NOT REALLY IN OUR LIVES ANYMORE." "I-I THOUGHT HE WANTED TO BE A F-FATHER, BUT HE WALKED OUT." "ANY IDEA WHERE HE MIGHT BE?" "HE'S " " HE'S A HUMVEE MECHANIC IN THE ARMY, IF THAT HELPS." "DON'T WORRY." "WE'LL FIND HIM." "NOW, WHEN YOU WERE OUTSIDE UNLOADING THE GROCERIES," "DID YOU SEE ANYONE?" "A GARBAGE COLLECTOR, MAIL CARRIER," "NEIGHBOR, ANYONE AT ALL?"


PAY FOR DOCTOR BILLS," "NURSERY STUFF." "I WAS IN LOVE WITH THAT KID BEFORE I EVEN MET HIM." "I WAS BUMMED WHEN I MISSED HIS BIRTH." "SO MY FRIENDS, THEY THREW ME A PARTY." "AND THE BEST GIFT CAME FROM MY C.O." "TRANSFERRED ME BACK STATESIDE" "SO I COULD GO HOME AND SEE MY SON." "I DIDN'T TELL LUCY THAT I WAS COMING" "BECAUSE I WANTED TO SURPRISE HER." "HEY." "WHAT THE HELL?" "ANDREW." "WHERE'S OWEN?" "I CAN EXPLAIN." "EXPLAIN WHAT?" "THAT YOU LIED TO ME?" "LOOK, NO." "OH, MY GOD." "TELL ME THIS IS NOT HAPPENING!" "TELL ME THIS IS SOME SORT OF A JOKE!" "PLEASE." "DON'T TOUCH ME!" "I WAS SUCH AN IDIOT." "ALL THAT BULLSHIT" "ABOUT THE DOCTOR BILLS, THE NURSERY STUFF." "SHE WAS JUSTTHE MOTHER HAD COME BACK." "LOOK, I KNOW I DIDN'T HANDLE EVERYTHING PERFECTLY," "BUT I SAVED THAT BABY." "NO, LUCY SAVED HER BABY." "SHE WAS AFRAID SHE WAS GONNA BECOME LIKE HER MOTHER," "AND SOMEHOW SHE FOUND THE STRENGTH TO DO THE RIGHT THING." "YOU, ON THE OTHER HAND," "TOOK SOMETHING THAT DIDN'T BELONG TO YOU." "I BELIEVE IT'S CALLED KIDNAPPING." "BUT YOU DID A WHOLE LOT MORE THAN THAT, DIDN'T YOU?" "WHAT?" "WHAT " " WHAT ARE YOU -- WHAT ARE YOU TALKING ABOUT?" "OH, COME ON, SCOTT." "YOU STOLE HER BABY," "AND THEN YOU KILLED HER TO COVER IT UP." "WHAT?" "YOU SAW LUCY ON THE NEWS" "SAYING THAT HER BABY HAD BEEN ABDUCTED." "YOU WERE AFRAID THAT SHE WAS GONNA TELL THE COPS" "THAT OWEN


MAKE A BABY." "YOU'VE COME TO THE RIGHT PLACE." "I SPEND HUNDREDS OF HOURS ON EACH OF MY CREATIONS." "IT SEPARATES ME FROM OTHER REBORN ARTISTS." "EVERY TINY VEIN AND BIRTHMARK AND MILK SPOT" "IS HAND-PAINTED WITH EXQUISITE ATTENTION TO DETAIL." ""CONGRATULATIONS ON BECOMING A PROUD PARENT" ""OF AN ADOPTED REBORN." ""YOUR CHILD IS NOT A TOY BUT A DELICATE HEIRLOOM" ""THAT WILL BRING DECADES OF JOY" "TO YOU AND YOUR FAMILY IF PROPERLY MAINTAINED."" "HON?" "HMM?" "GET A LOAD OF ALL THESE RULES." ""DON'T SMOKE AROUND THE BABY." SURE." ""DON'T BATHE IT, DON'T PULL TOO HARD ON ITS LIMBS," ""DON'T WEAR LOTION WHEN HANDLING IT," ""DON'T LEAVE DOGS ALONE WITH IT" "LEST THEY MISTAKE IT FOR A CHEW TOY."" "WOW." "THIS MIGHT BE HARDER THAN TAKING CAREThe data underlying the results presented in the study are available from the John Hopkins Coronavirus resource center. URL: <https://coronavirus.jhu.edu/map.html>.

Introduction {#sec001}
============

The first reported case of the novel coronavirus (SARS-CoV-2) in South Africa was announced on 5 March 2020, following the initial manifestation of the virus in Wuhan China in December 2019 \[[@pone.0237126.ref001]--[@pone.0237126.ref003]\]. Due to its further spread and the severity of its associated clinical outcomes, the disease was subsequently declared a pandemic by the World Health Organisation (WHO) on 11 March 2020 \[[@pone.0237126.ref001], [@pone.0237126.ref002]\]. In South Africa, by 26 April 2020, 4546 people had been confirmed to have been infected by the coronavirus with 87 fatalities \[[@pone.0237126.ref004]\].

Numerous states have attempted to minimise the growth in number of COVID-19 infections \[[@pone.0237126.ref001], [@pone.0237126.ref005], [@pone.0237126.ref006]\]. These attempts are largely based on


literature, without accounting for any social distancing policies the *R*~0~ for COVID-19 is between 2 and 3.5 \[[@pone.0237126.ref002], [@pone.0237126.ref006], [@pone.0237126.ref010], [@pone.0237126.ref011]\]. *R*~0~ can be expressed in terms of λ and *μ* as: $$\begin{array}{r}
{R_{0} = \frac{\lambda}{\mu}} \\
\end{array}$$

### Extensions to the SEIR and SIR models {#sec006}

We use an extended version of the SEIR and SIR models of \[[@pone.0237126.ref006]\] that incorporates some of the observed phenomena relating to COVID-19. First we include a delay *D* in becoming infected (*I*^new^) and being reported in the confirmed case statistics, such that the confirmed reported cases CR~*t*~ at some time *t* are in the form \[[@pone.0237126.ref006]\]: $$\begin{array}{r}
{\text{CR}_{t} = I_{t - D}^{\text{new}}} \\
\end{array}$$

We further assume that the spreading rate λ is time-varying rather than constant with change points that are affected by government interventions andcurrent state using gradient information, which assigns the current state a trajectory towards a high probability next state \[[@pone.0237126.ref015]\]. The dynamical system formed by the model parameters *W* and the auxiliary momentum variables *p* is represented by the Hamiltonian *H*(*W*, *p*) written as follows \[[@pone.0237126.ref015], [@pone.0237126.ref016]\]: $$\begin{array}{r}
{H\left( W,p \right) = M\left( W \right) + K\left( p \right)} \\
\end{array}$$

Where *M*(*W*) is the negative log-likelihood of the posterior distribution in [Eq 7](#pone.0237126.e007){ref-type="disp-formula"}, also referred to as the potential energy. *K*(*p*) is the kinetic energy defined by the kernel of a Gaussian with a covariance matrix *M* \[[@pone.0237126.ref017]\]: $$\begin{array}{r}
{K\left( p \right) = \frac{p^{T}M^{- 1}p}{2}.} \\
\end{array}$$

The trajectory vector field is defined by considering the parameter space as a physical system that follows Hamiltonian Dynamics \[[@pone.0237126.ref015]\]. The dynamical equations governing the trajectory of


the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data---e.g. participant privacy or use of data from a third party---those must be specified.

Reviewer \#1: Yes

\*\*\*\*\*\*\*\*\*\*

5\. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, soregulations governing the body of water. Many reservoirs do not allow private ownership of waterfront property. In these lakes, there tends to be large marinas or “dockominum” structures. In these structures in-water mooring is the most common. A small percentage of the boats are lifted using a floating lift. Floating lifts are usually the only type allowed on a large dock structure. Marina managers discourage any structure being fixed to these floating systems.
Many lakes and waterways allow private waterfront ownership. In these cases, a permanent, fixed pier can be installed. Often a permanent roof structure is built over the slip intended for the boat commonly called a “boat house”. When these structures are present, a large percentage will have a mounted lift system. Some permanent docks do not