who can purchase or use WORX WG800.1 3.6 Volt Lithium Grass and Hedge Trimmer. It is a perfect choice for small touch up shrub and hedge jobs.

Did you know that the shape and appearance of your landscape hedge has a direct impact on the beauty and value of your home?

You should maintain your homestead’s hedge by regularly trimming its branches.

Hedges that exhibit high vegetative characteristics should be trimmed at least three times every month while less vegetative hedges should be trimmed twice or once a month depending on your preferences.

Efficiency

This electric hedge trimmer is capable of trimming 1,200 square feet hedges when fully charged. It can be used to trim bushes, shrubs and hedges that exhibit varying growth characteristics. It weighs only 8.6 pounds hence it can bepurchase the former, but will probably only buy the latter if their professor requires it.

While I readily admit that I have no idea which management theory will next be advanced in the business world, I do hope that the next invalid one to be overturned is the codex developed by the academic statisticians, risk management theory. With the exception of insurance companies and pharmaceutical organizations, which rely heavily on statistical models, nobody follows the risk management theories laid out in documents like the Guide to the Project Management Body of Knowledge, or just PMBOK Guide® in order to improve project/product performance. These theories – hypotheses, really, since they are singularly untested in an experimental setting – are usually observed due to some institutionalized procedural requirement, but they produce


and Cernunnos-XLF adaptive evolution.

Pavlicek & Jurka base their proposal of adaptive evolution in chimpanzee and human Cernunnos-XLF upon 5 inferred nucleotide substitutions, all of which are proposed to have been nonsynonymous. The major issue in the authors\' conclusion of positive selection is whether the extremely short branch lengths of chimpanzee and human sequences affect predictions. For example, approximately 20% of chimpanzee/human divergence is due to substitutions that are not fixed. If any one of the 5 substitutions were discarded, would the significance of these findings remain? Similarly, if the chimpanzee sequence were to be discarded would the predictions still hold?

**Author response**: *We agree with the reviewers that some substitution(s) in the human/chimpanzee lineages may in fact be polymorphic mutations. Therefore, following the reviewers\' advice, for each of the\... possibly played a role in the expansion of brain size\". A similar sentence is used in the Abstract*.

\(5\) It is unclear whether Figure [3](#F3){ref-type="fig"} is required.

**Author response**: *The macaque coding sequence is crucial for estimating the ancestral state before the split of humans and chimpanzees and therefore we prefer to include it in some form in the manuscript. The figure can be moved to a supplement, but since the manuscript is very short (and the journal is electronic), we decided to keep Figure*[3](#F3){ref-type="fig"}*in the main text*.

Reviewer\'s report 2
--------------------

Kateryna Makova (assisted by Erika Kvikstad), Department of Biology, 518 Mueller Lab, Penn State University, University Park, PA 16802

The manuscript by Adam Pavlicek and Jerzy Jurka contributes new information to the list of human genes evolving under positive selection. The


positive selection in the recent population (Haplotter, the empirical p-values are 0.148074, 0.607928, and 0.999954). More surprisingly, even ASPM and microcephalin, which are both known to be under selection in the recent human population (Mekel-Bobrov et al. 2005 Science 309:1720-2; Evans et al. 2005 Science 309:1717-20), do not show any significant selection from HapMap data either (ASPM: the p-values are 0.999955 for CEU, 0.225666 for YRI, and 0.539616 for ASN; microcephalin: the p-values are 0.547812, 0.171512, 0.544621). This discrepancy is probably related to data selection (resequencing of 89 individuals versus public HapMap data) and also a high variability in the strength of selection between different human populations*.

*Interestingly, Bustamante et al. 2005 (Nature 437:1153-7.) found two nonsynonymous and no synonymous polymorphic positions within the human population. Thus it isinterpretation compatible with the data. I think it is impossible to rule out the possibility that XLF has another, still uncharacterized, perhaps, brain-specific function that is modified by the replacements in the human lineage; it is well known that protein moonlighting is common. However, nothing contradicts the authors\' hypothesis either, and it could be argued that, for the moment, this is the most parsimonious explanation of the data.

**Author response**: *We agree with reviewers that the role of Cernunnos-XLF in human brain expansion is speculative. In the last paragraph of the Discussion we wrote that: \"While association of Cernunnos-XLF selection with increased brain size is attractive in the context of simultaneous adaptation of several brain size determinants, there are also other possible explanations.\" Two such explanations are mentioned in


is to describe everything they do as “useless”, and there is a lot of “typical man” disparaging sentiments . The idea of having a special day where it would be perfectly normal to buy your husband flowers and cook him a special meal would be laughed out of town. Yet in an egalitarian society like Iceland, even the men get their own special day. 🙂

8. Not judging single mothers. Iceland does have a high proportion of babies born outside wedlock. People aren’t judgmental about it. Apparently, it is because there is a long tradition of single mothers, as throughout history, most of the men were involved in fishing and had more chance of dying young and leaving them on their own.

9. Calling people by their first names. Thisare at least getting older now when they have kids now, im a product of teenage pregnancy 😉 you learn alot from that.
Although they think its “unnormal ” to be in my age and not have kids!! ( in Denmark im very normal ;-))
And they will rather have kids with a guy, but getting married!!! thats serious!.. 😉

Swimming pools, love it and miss it, i live at the swimming pools every time i visit home 🙂 we are priviliged in Iceland, with our natural sourses and hot water.

I would like to add to your list a popular avent in the winter time, we rent a sommerhouse, go with a group of friends during weekends and stay there cooking good food, bathing in the hut tub while we look


so at least it actually is worth the money for someone who is only coming to visit once and wants a unique experience that sounds really impressive to your friends. It’s good that there are no big “children’s attractions” in Iceland as those are often the tackiest. Thanks for visiting!

Are there Asian people in Iceland? Are iceland people friendly? My husband and I plan to visit in 3 year and i am praying the date will come sooner. but I’m little concern of ppl not being kind to me of my race

Dont worry. Icelanders are known for their hospitality to people all over the world. There have been groving numbers of tourists from Asia and they are welcome. People from Thailand and the Philipease are one of thethere, and I miss my Icelandic friends. Iceland is a wonderful country with the friendliest people I ever had the chance to meet in my life. It is absolutely beautiful there, and I hope to return one day.

No one has mention the Christmas cat or the lenght of the Christmas season from 24/12 -06/01 and we keep the decoration´s at least that long. Or the wisdom sentence in the Eastern eggs ( always chocolate eggs) or the Icelandic special food as “Thorramatur” . What about new year eve? You have to experience it. How many months can people stay home with the newborn baby in USA on salary ? In Iceland we can stay home many-many months

No, it’s not false at all. Icelandic women on average make around


Introduction {#s1}
============

*Candida albicans* (*C. albicans*) is, a dimorphic fungus, the most common pathogen of humans among fungi and a component of the normal microflora of skin, mucosa and alimentary tract of the healthy host [@pone.0083517-Newman1]. However, when immune defenses are compromised or the normal microflora balance is disrupted, *Candida* transforms itself into an opportunistic pathogenic killer. Indeed, dissemination of *Candida* is the leading cause of invasive fungal disease in diabetics, premature infants, and surgical patients and of oropharyngeal disease in AIDS patients [@pone.0083517-Oliveira1], [@pone.0083517-AlAttas1], [@pone.0083517-Pereira1]. *C. albicans* exhibits the ability to grow in a variety of reversible morphological forms \[yeast forms (Y), pseudohyphal forms, and hyphal forms (H)\] in response to various environmental signals [@pone.0083517-Lane1]. The ability of *C. albicans* to switch its mode of growth has beenand TLR4 are expressed very extensively (e.g., monocytes, macrophages, immature DCs, T cells and B cells), and play critical roles in recognition and signaling of *C. albicans*. Recognition of *C. albicans* by TLR2 and TLR4 on the monocytes activates intracellular signaling pathways that trigger production of proinflammatory cytokines and chemokines that are critical for innate host defence and orchestrate the adaptive response [@pone.0083517-Gil1]. In this study, we also assessed the effect of TLR2 and TLR4 in the *C. albicans-* induced model by using anti-TLR2 and anti-TLR4 Ab. The experiment results showed that both anti-TLR2 mAb and anti-TLR4 mAb could partially suppress IL-8 and TNF-α production from *C. albicans* -induced THP-1 macrophages independently. All researching results further proved that *C. albicans* induced cellular responses of PMA-activated THP-1 cells were


lead to less NF-κB activation by *C. albicans*, what leads to less mRNA synthesis and less protein production. In addition, the binding can be partially inhibited by both anti-TLR2 monoclonal antibody (clone TL2.1) and anti-TLR4 monoclonal antibody (clone HTA125), indicating that not only TLR2 but also TLR4 are the binding site (ligand) for MBL expressed on PMA-activated THP-1 cells. To actually demonstrate an interaction between MBL and TLRs, we prepared a soluble form of recombinant extracellular TLR2 domain (sTLR2) and sTLR4, and co-immunoprecipitation experiments and microtiter wells assay were used to evaluate the binding of MBL to sTLR2 or sTLR4. The experiment results showed that MBL could directly interact with sTLR2 and sTLR4. All these suggest that the ability of MBL is versatile in immune regulation.

To further investigatethe possible mechanism, we examined the transcript levels of TLR2 and TLR4. Our data clearly demonstrated that expressions of TLR2 and TLR4 in PMA-activated THP-1 cells could be induced by both Y cells and H cells. These expressions induced with HK *C. albicans* were profoundly inhibited by MBL at higher concentrations (10∼20 mg/L) but not MBL at lower concentrations (1 mg/L). All these data further prove that MBL regulates *C. albicans*-induced cellular responses of human PMA-activated THP-1 macrophages through TLR2 and TLR4.

It would seem counterintuitive that a protein that inhibits human macrophages function would arise acutely just at the time when vigorous immune stimulation is most needed (one to several days post infection). Normally, this is a desirable homeostatic mechanism that would come into play after sterilizing immunity


had been achieved. In addition, it is interesting that Ip *et al*. [@pone.0083517-Ip1], [@pone.0083517-Ip2] have reported that MBL could increase signaling from TLR2 and TLR6, and Shimizu *et al*. [@pone.0083517-Shimizu1] recently showed that recombinant MBL could interact with TLR4 and MD-2. More recently, we proved that MBL could bind to TLR4 directly, and suppress LPS-/TLR-mediated biological function [@pone.0083517-Wang2]. The finding of an inhibitory effect of MBL on *C. albicans*-induced immune responses of human macrophages through TLR2 and TLR4 in this study further demonstrated the versatile ability in immune regulation of this member of the collectin family.

Chemokines are chemoattractant cytokines that play crucial roles in host defense against infectious agents by their ability to induce and regulate magnitude and composition of leukocyte influx at the infected site. Furthermore, theyThe fourth author's name is spelled incorrectly. The correct name is: Shailesh B. Raval.

The correct citation is: Wood S, Krishnamurthy N, Santini T, Raval SB, Farhat N, Holmes JA, et al. (2017) Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes. PLoS ONE 12(8): e0183168. <https://doi.org/10.1371/journal.pone.0183168>.

An affiliation for the fourth author is missing. Shailesh B. Ravel is affiliated with both \#1 and \#3 Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.


groups (n = 13). Subjects were tested prior to beginning supplementation and a 10-week strength program, and immediately post-training. All subjects were measured for circulating levels of testosterone, insulin-like growth factor, erythropoietin, red cell mass, plasma volume, and total blood volume. Additionally, muscular strength, endurance, and VO2max were determined. All groups improved 6 RM strength equivalently (41 +/- 26%, p < .001), but there was a greater increase in isokinetic knee extensor strength (30 +/- 21% vs. 13 +/- 15%, p = .04) and endurance (21 +/- 19% vs. 7 +/- 12%, p = .02) in the powder compared to placebo group. There were no endocrine, red cell mass or VO2max changes in any group. These findings do not support an erythropoetic or aerobic ergogenic effect of deerand 122 are formed on one and the other antenna terminals 131, respectively. In the cases of parts (B) and (D) of FIG. 5, both of two antenna terminals 131 are formed on only one of two mounting pads 121 and 122, and the normal operation as the RFID tag cannot be performed if nothing is done.
In other words, in the case of combinations of the circuit chip 13B having the terminal arrangement shown in FIG. 4 and the mounting pads 121 and 122, there is a need to accurately manage postures of the circuit chip 13B in the rotation direction one by one when the circuit chip 13B is mounted, resulting in a large reduction in production efficiency, which causes serious impediments to mass production and cost


239 Kan. 221 (1986)
718 P.2d 1302
JOHNSON COUNTY MEMORIAL GARDENS, INC., Appellant,
v.
CITY OF OVERLAND PARK, BOARD OF ZONING APPEALS OF THE CITY OF OVERLAND PARK, and ED FICKES, Appellees.
No. 58,476
Supreme Court of Kansas.
Opinion filed May 2, 1986.
Michael J. Gallagher, of Wassberg, Gallagher & Jones, of Kansas City, Missouri, argued the cause, and Thomas M. Franklin, of the same firm, and Charles D. Kugler, of Vasos, Kugler & Dickerson, of Kansas City, Kansas, were with him on the brief for appellant.
Henry Cox, assistant city attorney, argued the cause, and Rod L. Richardson, and Thomas D. Billam, of Wallace, Saunders, Austin, Brown and Enochs, Chartered, of Overland Park, were with him on the briefs for appellees.
Edwin P. Carpenter, of Hiatt & Carpenter, Chartered, of Topeka, was on the amicus curiae briefnot apply to Memorial Gardens, (4) money damages, and (5) other relief.
*223 Upon stipulated facts all parties moved for summary judgment. On July 18, 1985, the district court ruled in favor of the defendants and sustained their motion for summary judgment. The court found that Overland Park could properly zone plaintiff's land, that the preexisting use as a cemetery did not prohibit an R-1 underlying zoning classification and that state laws dealing with cemeteries did not preempt the field. The court also found that Memorial Gardens had failed to pursue and exhaust existing administrative remedies, and that such inaction precluded the granting of any of plaintiff's requested relief. Memorial Gardens now appeals to this court. Although appellant asserts several arguments, the controlling issues may be summarized as (1)


*226 City's master plan. Further, the cases cited by both parties reveal that the designation of underlying zoning for cemetery properties is neither unusual nor unlawful in other jurisdictions. See generally, 96 ALR 3d 921. Plaintiff argues the City does not have the power to designate the underlying use of the land as R-1, or any use other than as a cemetery, and therefore the present use and the proposed construction of a maintenance building on the property is within the scope of the lawful use of the property as a cemetery. Further, Plaintiff argues that the City may not exercise the zoning power it may have over this property by use of an ordinance authorizing issuance of a `Special Use Permit.' This contention presumes that when aany unreasonable hardships imposed thereby before the aggrieved party may enter into litigation. The Court specifically finds that had the Plaintiff applied for a Special Use Permit this procedure could have alleviated any harmful consequence of the ordinance and that said administrative remedy must be sought before the Plaintiff will be heard to say that he has been injuriously affected.
"7. The Court finds that city zoning laws are not pre-empted by state laws on cemeteries. The fact that the property in question was dedicated for use as a cemetery prior to its annexation by the Defendant and the Defendant's subsequent enactment of zoning ordinances, the application of which makes the Plaintiff's cemetery a non-conforming use, does not deprive the City of Overland Park of its power to restrict


courts for relief. We see no need to repeat here what has been so recently said in that opinion.
We hold that the City of Overland Park had the authority to classify for zoning purposes the Memorial Gardens property as R-1 (single family residential) and to require appellant to seek a special use permit for its proposed building construction. We also hold that as appellant did not exhaust its administrative remedies, the filing of this lawsuit was precluded. In view of the decision reached herein, the remaining issues need not be considered.
The judgment is affirmed.
Agarwal; Dr Tanunita Mondal; Prof Dr Subodh Satyarthy*

**INTRODUCTION:**

Pseudoaneurysm of ascending aorta following cardiac surgery is a rare complication.Ṃosltly patients are asymptomatic.If untreated it may increase in diameter and may get ruptured.Rarely it may erode sternum and ṃay present as pulsatile superficial swelling.

**BACKGROUND:**

We here reporta case of pseudoaneurysm of aorta 2 years after Double valve replacement(DVR) in a 18 years old male patient presented with a pulsatile swelling over the sternum.

**CASE:**

An 18 year old male post DVR 2 years back presented to us with a gradually progressive pulsatile and expansile swelling over the sternal scar near the suprasternal area for 15 days.There was no history of trauma,high grade fever.Chest X-ray Echocardiography and Computed tomography(CT) scan showed a swelling originating from near the aortic root with features suggestive of pseudoaneurysm.

Patient


at T3-4 level.Blood pressure was equal in both upper limbs.

Surgical correction was performed via median sternotomy. The proximal aberrant artery was mobilized behind the esophagus. The distal, right subclavian artery was exposed, transected and 8mm PTFE graft interposed between ascending aorta and distal part of right subclavian artery.Postoperatively patient was symptom fee and discharged on POD7.

An aberrant right subclavian artery (ARSA) is an anomaly with a reported incidence of 0.5%- 2%. ARSA can be explained by the involution of 4th vascular arch with right dorsal aorta and the persistent 7th intersegmental artery becomes right subclavian artery which often follow a retroesophageal course; rarely it takes a course anterior to the esophagus or the trachea. Most patients with an ARSA remain asymptomatic; however, progressive dysphagia develops occasionally. The choiceof grafts were 227.There were 78 LIMA grafts and 149 vein grafts. In 55 cases the bypass grafts were performed on beating heart whereas in 45 cases the grafts were performed under cardio pulmonary bypass and there was no difference in the number of grafts between the two techniques.

**RESULTS:**

All the check angiograms were targeted i.e., it was performed in patients only with post operative recurrence of anginal symptoms. The patency of the SVG was 77 % at 7 years and 6 months. 115 vein grafts were patent out of 149.

**CONCLUSION:**

Our results confirm that vein grafts are durable conduits with good patency rates and will remain the mainstay in bypass surgery, considering the ease of harvest, operability and safety.

***Afilliations:***

^**1**^ *Apollo Hospital, Madurai, Tamilnadu, India*

**Pacemaker Lead Perforation of Rv Apex


communication between left ventricle and right atrium. It was first described by Thurnman in 1838. First successful closure of Gerbode defect was done by Kerby et al using hypothermia and inflow occlusion technique. Dr Gerbode described first successful series of patients operated on with a left ventricle to right atrium shunt in 1958. It presents as left to right shunt which may be direct or indirect. In direct type, there is a direct communication between left ventricle and right atrium. In indirect type, there is a perimembranous ventricular septal defect and a defect in the tricuspid valve. Here, the shunt is from left ventricle to right ventricle through perimembranous ventricular septal defect and to right atrium through the defect in tricuspid valve. Direct type is mostly acquired wheredirectly into RA. Two commonly done surgical procedure for this anomaly are Tuckers and Van Praagh repair.

**MATERIALS AND METHODS:**

Retrospective study Period : January2014 to December 2016.Number of cardiac TAPVC repair n=14 of which Tuckers done in 8 patients (Group A)(n=8) and remaining (Group B) (n=6) underwent Van-praagh .The patients pre-op,intra-op,post-op , follow up datas were analysed and compared.

**RESULTS:**

The mean age of patient in group A is 4.6 months and group B is 23.16 months. The most common presenting symptom in both groups were RRTI(54%). Pre-op echo showed common chamber draining into coronary sinus in all patients. Group A mean CPB time and AXC is 155.37mins, 94.37mins and 98.16mins, 56mins in group B respectively. The median duration of ventilation and ICU stay is 72 hours and 5 days in


in single patient.With one year post operative follow up.

**BACKGROUND:**

The incidence of TAPVC is 2% to 3% of all congenital heart diseases.Different types of TAPVC has been well documented, mixed supra- and infracardiac being a rare presentation.

**CASE :**

26 days old male child,with body weight of 1.96 kg diagnosed to have obstructed supracardiac type of TAPVC was taken up for repair.On the operating table ,we found both left upper and right upper lobe pulmonary veins were forming a common chamber which was draining through oblique vein in to innominate vein(Supracrdiac).Left middle and left lower pulmonary veins and right middle and right lower pulmonary veins were forming a common chamber which was draining into the abdominal component through diaphragm(Infracardiac). The oblique vein was dissected and its connection to SVC was identified.arteriosus. The presence of concomitant tubercular constrictive pericarditis in such patients presents an additional challenge in its management.

**CASE:**

A 25 year old female, known case of pulmonary tuberculosis presented with complaints of recurrent fever and chills. On Echo a large PDA with vegetation in MPA and pulmonary end of PDA with thickened pericardium and asymmetric effusion was seen.

Patient underwent PDA patch closure through pulmonary arteriotomy under DHCA and anterior pericardiectomy.

**CONCLUSION:**

Adult PDA along with constrictive pericarditis is a unique presentation and imposes a surgical challenge. Careful dissection of the pericardium from the heart to avoid myocardial injury, PDA patch closure and concomitant pericardiectomy is advised to prevent further morbidity attributable to tuberculsosis.

***Afilliations:***

^**1**^*PGIMER, Chandigarh, Chandigarh, India;* ^**2**^PGIMER, Chandigarh, Chandigarh, India

**Bilateral Bidirectional Glenn Shunt in a Case Of Double Outlet Right Ventricle


have reported complications of per-cutaneous transluminal angioplasty.

**BACKGROUND:**

Myocardial infarction is the major complication but we believe that guide-wire fractures are also not so rare and such cases are under-reported. The complication of device fracture during the intervention procedure occurs due to entrapment, over coiling and excessive traction of the guide wire.

**CASE:**

We report a 68- year- old man with a history of stable angina pectoris who was hospitalized in our cardiology ward for evaluation and treatment. Angiography showed total occlusion of left anterior descending coronary vessel. The patient was scheduled for PTCA. The guide wire was trapped between the stent and the vessel wall, and did not come out after insistent traction and finally broke. The broken part of the guide-wire was in LAD and the proximal end was pointingliterally live with patients coronary artery and vascular system ,its not at all surprising then,man made cardio vascular accidents are becoming more common where pieces of hardware like guide wires , catheters and stents gets trapped.

**BACKGROUND:**

though knowing about the hardware and techniques of retrieval of foreign bodies with in vascular system like 1)gooseneck snare 2)en snare multiple loops 3)microelite snare , it may sometimes leads to failure.

**CASE:**

rajesh kumarwho is a 49 year old male a case of coronary artery disease , old inferior wall myocardial infarction , post per cutaneous intervention and rca stenting in 2013 followed by recent anterior wall myocardial infarction . pci to lad resulted in broken wire in diagonal which couldnot be retrieved by conventional interventional methods . finally patient underwent cabg to diagonal


of grafts required, use of IABP, post-operative complication, mortality, mean hospital stay, post-operative improvement in EF, and post-operative control of angina and symptomatic improvement.

**RESULTS:**

The hospital mortality rate in present series was 11%, mean grafts were 3.02 per patient. Fourteen (40%) patient had a post-operative complication. EF improved in 78% of patients. Canadian Cardiovascular Society Angina class improved in 42% of patients.

**CONCLUSION:**

In patients with coronary artery disease and low EF, CABG can be performed safely, and improvement in left ventricular function can be achieved with this procedure improving the quality of life. It results in good medium term survival, improves left ventricular function and enhances overall quality of life.

***Afilliations:***

^**1**^ *Vydehi Institute Of Medical Sciences, Bangalore, Karnataka, India*

**A Rare Presentation of Coronary Artery Disease With Carcinoma Oesophagus Dealt Simultaneously** ~*254*~

***T***LAD stent. Circumflex and right coronary are free of flow limiting disease. Intraoperatively, patient was put on cardiopulmonary bypass support in view of LV dysfunction. LAD mid segment area showed 5x2cm epicardial swelling, which upon opening was found to be an abscess cavity with pus. DES stent was seen lying freely. Stent extracted and pus was sent for culture.

**DISCUSSION:**

Diagnosis of stent infection is challenging as the incidence is very rare and there is no single modality for confirming the diagnosis. Clinical suspicion should be high in patients who underwent coronary intervention and presenting with unexplained fever, positive blood cultures and chest pain.Surgical intervention is necessary in most of the cases with overall high mortality 38.9%.

***Afilliations:***

^**1**^ *Apollo Specialty Hospitals, Vanagaram, Chennai, Tamil Nadu, India*

**Ambidextrous Left Internal Mammary Artery Harvest


necessity for finding a solution to repair and regenerate the ischemic and scarred myocardium.

**MATERIALS AND METHODS:**

Retrospective study of 115 patients (Range-4 months to 85 years) undergoing autologous bone marrow derived mesenchymal stem cell\[MSC\] therapy via transcoronary and intramyocardial route. 96 patients presented with Ischemic Dilated Cardiomyopathy\[DCM\], 19 cases presented with Idiopathic/viral DCM.59 patients were in NYHA class 3\[52.67%\]. 56 patients \[47.8%\] were in NYHA class 4 on presentation.Clinical Trial with MSC was registered in September 2010 with ICMR as phase 2.

**RESULTS:**

Out of 115 patients,85 cases (73.91%) were done by transcoronary route, 30 cases (26.08%) by intramyocardial route. 48 cases received stem cell therapy alone, 38 cases received stem cell therapy along with Coronary artery bypass graft(CABG), 19 cases received stem cell therapy along with Stenting. 33 patients were8 cm aneurysm with mouth measuring 5.2 x 6 cm, adjacent to P2, P3 segment and protruding between Left ventricular wall and diaphragm. Coronary and ventricular angiogram showed normal coronaries with LCx adjacent and superior to mouth of aneurysm. LA was uninvolved with no MR. Patient developed features of tamponade and was operated on next elective list under CPB. Aneurysm wall was opened and direct exclusion of aneurysm was done using treated pericardium and Teflon strips. Post procedure TEE showed mild MR with no sac. Patient was discharged with uneventful perioperative period and post op echo showed small residual sac and trivial MR. Evidence for concomitant mitral valve repair is currently lacking.

**CONCLUSION:**

SMAs are rare cardiac conditions presenting with myriad of manifestations and indications for associated mitral valve repair


test parameters that were compared were -- total bilirubin, direct bilirubin, alkaline phosphate (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The data was recorded in a standard proforma.

**RESULTS:**

Our study showed significant increase of total bilirubin, direct bilirubin, ALP, AST and ALT on the first and second post-operative days in patients who underwent complex surgeries (i.e. Bentall's procedure and Rastelli's procedure) and valve replacement surgeries under CPB. Patients with increased pre-operative hepatic enzymes had interestingly significant reduction of hepatic enzymes during their post-operative period.

In our study, we found that patients with normal hepatic enzymes pre-operatively had elevated hepatic enzymes on post-op days 1 and 2 due to longer durations on CPB.

**CONCLUSION:**

When compared to total bilirubin and direct bilirubin, hepatic enzymes ALT and AST were significantly increased during thereversible cardiomyopathy(7-10days). We present our experience with a patient who had sepsis, cardiomyopathy supported on VA-ECMO successfully to recovery.

**CASE REPORT:**

A 52-year old gentleman was brought with hypotension. He had a short history of illness started on antibiotics, deteriorated rapidly, suffered a cardiac arrest and was revived in a neighbouringhospital. Initial evaluation showed moderate ventriculardysfunction. He was started on inotropes; cultures were sent as part ofthe investigations.

Coronary angiography showed normal coronary arteries. He required escalating doses of inotropes and was soon on maximal doses of multiple inotropes, was intubated. His ventricular function dropped to an LVEF of 15% and was in severe shock. Hence it was decided to support him on ECMO.

VA ECMO was established with femoral arterial cannulation through a 8mm dacron tube graft anastomosed end-to-side to the


Seventy five patients (72.1%) had brachiocephalic fistula while 29(27.9%) had radiocephalic fistula. We did not use graft in any patient. Overall complication rate and primary failure rate were 10.6% and 14.4% respectively. In univariate analysis, age more than 60 years, female, diabetic patient and radiocephalic fistula site had influence on primary failure of fistula (P\<0.05). However, female (OR;9.46, 95% CI\[1.51-59.26\], P=0.001), diabetes (OR;10.37, 95% CI\[1.98-54.37\], P=0.006 )and rediocehalic fistula site (OR;6.95, 95% CI \[1.42-33.99\], P=0.017 ) were the in dependent risk factors for primary failure of fistula in multivariate logistic regression analysis.

**CONCLUSION:**

Primary failure is more likely in female diabetes and radiocephalic fistula site. Surgeon should be vigilant while choosing patient , technique and follow-up practices for arteriovenous fistulas.

***Afilliations:***

^**1**^ *Universal College Of Medical Sciences, Bhairahawa, Rupendehi, Nepal*

**External Jugular Veinshare our experience tackling Great Saphenous vein bypass graft rupture- a entity not frequently reported. We also shed limelight upon etiology for bypass graft aneurysm and preventive modalities which can be adopted to overcome the problem after going through various past studies.

**METHOD:**

Our patient twice underwent Great Saphenous Vein Bypass Graft tear closure after a month following Left Femoropopliteal bypass graft surgery for distal superficial femoral artery pseudoaneurysm after the necessary investigations and ethical pre operative formalities.

**RESULT:**

Patient underwent the procedure where vein graft tear following aneurysmal rupture was patched up with PTFE graft but later coursed through an eventful post operative period resulting in a successful reoperation where the hand sewen closure of the tear was performed. At the end of the day Patient had his limb saved by


Kar Medical college a tertiary care institute in kolkata, India.

**RESULTS AND ANALYSIS:**

Despite the golden rule about warm ischemia time (upto 6 hrs) we have found comparable results even in intervention group of up to 24 hrs. We found higher chances of infection (up to 50%) in late intervention group which have significantly contributed to the limb viability. Other complication such as Pseudoaneurysm,bleeding and graft thrombosis shows no significant variation in the late or early group. Added procedures those that are required in cases of polytrauma such as laparotomy, bony stabilization also affected limb viability and were contributory.

**CONCLUSION:**

Patients presenting after 6 hours and if the limb is found to be viable he should definitely be operated in an attempt to salvage the limb. Peripheral vascular injury is an emergencyusing ipsilateral or contra-lateral axillary artery, which is a less invasive procedure.

**BACKGROUND:**

In 1963, Blaisdell and Hall successfully performed the first Axillo femoral bypass graft (AXFBG). AXFBG was performed even under local anesthesia, who could not tolerate general anesthesia.AXFBG provided a major advantage by avoiding abdominal incision and cross-clamping of the aorta. In 1966, Sauvage and Wood performed the first axillobifemoral bypass graft.

**CASE:**

A 58 years old male with nil premorbiditis and chronic smoker, presented with right lower limb rest pain for 3 months. Patient had ankle brachial index of 0.2.no gangrenous changes .CT angiogram showing severe calcification from infra renal aorta with total occlusion of right external iliac artery and superficial femoral artery and reformation at popliteal artery. As the patient had extensive AID, patient was operated for right


Balasubramoniam* ^*1*^

**INTRODUCTION:**

Pulmonary Arteriovenous Fistula

Desaturated blood in the pulmonary artery is shunted through the fistula into the pulmonary vein, resulting in systemic arterial desaturation and cyanosis. There are 4 four main forms:

1.A single fistula.

2.Multiple discrete fistulas with one or a few predominant lesions.

3.Multiple discrete fistulas of a similar size.

4.Hereditary haemorrhagic telangectasia (Osler--Weber--Rendu disease)

**BACKGROUND:**

21 year old male who was a case of Bilateral Pulmonary AVM diagnosed in 2003 and had undergone Coil embolisation at the age of 7 years. Now presented again with Bilateral pulmonary Arteriovenous malformation with Right moderate hemothorax.

**CASE:**

21 year old male having chest pain, fever and breathlessness for 2 weeks duration. No known comorbidities. Now diagnosed with Bilateral pulmonary Arteriovenous malformation with Right moderate hemothorax. Coil embolisation of the Right upper lobe pulmonary AVM was done. Thebronchogenic cyst to be 13 - 15% of congenital cystic lung disease in infants and children. It is uncommon to present during adulthood. Here we present a case of infected bronchogenic cyst misdiagnosed as loculated pyopneumothorax in 22 year old postpartum mother.

**CASE:**

22 years old female patient presented with sudden onset of breathlessness in immediate postpartum period, diagnosed to have right pleural effusion for which tube thoracostomy done. Later referred to CTS department with airleak suspecting lung abscess/ pyopneumothorax. Patient was scheduled for right thoracotomy. Later cyst was removed completely.

**CONCLUSION:**

In view of the potential complications and diagnostic difficulty of the cystic lesions of the lung parenchyma one should suspect this possibilty when young adult patient present with suppurative infections. Conservative approach such as surgical excision of the cyst when


a period of 20 years with the intent of analysing our techniques, perfusion strategies and results.

**METHODS:**

From March 1996 till October 2017, 141 patients underwent redo aortic procedures (mean age 48 yrs, male 64%). The previous operations were aortic/mitral valve replacement,, Bentall's procedure, ascending aortic replacement, CABG and miscellaneous. The reoperations performed were aortic valve replacement , Bentall's procedure, prosthetic valve sparing root replacement, arch replacement, and Frozen elephant trunk procedure.Concomitant procedures included CABG, mitral valve replacement and tricuspid valve repair .Follow up period ranged from 3 months to 20 years.

**RESULTS:**

The cardiopulmonary bypass time ranged between 80 to 190 mins and the myocardial ischemic time ranged between 40-145 mins.Proximal arch/ascending aortic cannulation was preferred in most cases except in cases of dissection where axillary /femoral artery was the preferredto female ratio was 1.6:1. Among all the 956 congenital heart diseases operated in this period, Ebstein anomaly constituted 1.36%. The mean age of the patients operated was 18.9+8.5 years. Two patients, one of which who underwent Danielson repair and another who underwent cone repair developed heart failure in the post operative period and required prolonged inotropic support (more than seven days) along with prolonged hospital stay. There was one mortality, in a patient with a GOSE score of 3B who underwent tricuspid valve annuloplasty (with placation of atrialised RV).

**CONCLUSION:**

Various surgical modalities described for the management of this anomaly show variable outcome based on individual experience and institutional preference. Because of the rarity and variability of the disease and the possibility of institutional preferences for specific management strategies,


results and post operative course of 19 consecutive TOF repairs at our institute in a period of two years.

**RESULTS:**

The median age (3.2 vs 2.8 years) and weight (12.1 vs 11.5 kg) were similar for the cusp augmentation and trans-annular patch groups, respectively. The diameter of the pulmonary valve annulus (7.4 vs 7.6) and the Nakata index (116 vs 128) were also similar. The mean aortic clamp time (139 minutes vs 136 minutes) and median cardiopulmonary bypass time (178 vs 163 minutes) were comparable.

Post operative requirement for inotropes was lesser (3.4 vs 5.5 days) and recovery was faster (10 vs 14 days) for patients who underwent Sung's repair. Post operative 2 D echocardiography revealed moderate or more pulmonary insufficiency in 2 patients (22%) with Sung's pulmonary valve augmentoplasty versusthe bidirectional Glenn, we initially remove the lobe of the thymus on the side of the superior vena cava for better exposure in children after sternotomy. In patients with bilateral superior vena cavae, we excise it in toto. After completion of the surgery, prior to closure, we re-implant the excised thymus. We examined the specimens of the re-implanted thymus at the time of Fontan completion and report the findings.

**METHODS:**

Between July 1998 and September 2017, 244 patients underwent bidirectional Glenn and 127 of these patients underwent completion Fontan. At the time of the Glenn the excised thymic lobe/entire thymus was sutured over the aorta and innominate vein to the adjacent tissues using a few interrupted sutures. At the time of Fontan completion, the thymus was excised and examined.

**RESULTS:**

There were


26.2 mmHg (range: 34 to 169 mmHg). On preoperative echocardiography, aortic regurgitation (AR) was absent in 69 (47.3%), mild in 35 (24%), moderate in 30 (20.5%) and severe in 12 (8.2%). After surgery, the LVOT gradient was reduced to 15.1 ± 6.2 mm Hg (P\<0.001). 14 patients (9.6%) who had residual/recurrent significant gradients are currently being followed up or awaiting surgery.There was improvement in AR for operated patients with freedom from AR of 92.6 ± 0.03% at 15 years. Kaplan-Meier survival at 25years was 93.0 ± 3.9% (95% CI: 79.6, 97.7). Freedom from re-operation at 25years was 96.9± 1.8%.

**CONCLUSIONS:**

Long-term results of surgery for discrete SubAM are good. Resection of the membrane along with septal myectomy decreases the risk of recurrence.

***Afilliations:***

^**1**^ *Cardiothoracic Centre, All India Institute Of Medical Sciences,of 15mm Hg and mean MVA of 0.8cm2. Associated anomalies were ventricular septal defects in 14 patients (38.9%),abnormalities of the left ventricular outflow tract in 7 patients(19.4%) including 5patients with sub-aortic membrane,1 patient with HOCM and 1patient with BAV and 5 patients had LSVC (13.9%). Complete excision of ring was possible in all cases, without damage to the mitral valve. There was no in-hospital death (0%). Average stay in hospital was 6days with maximum of 9days to a minimum of 5days.Post-operative echocardiography revealed no gradient in any of the patients. Two patients had mild MR post-operatively which was managed conservatively, one patient developed pericardial effusion, which was drained uneventfully. At a mean follow-up of 60 months, no patient has mitral stenosis.

**CONCLUSIONS:**

Patients with supramitral ring have a relatively good


a 2 months baby with ALCAPA, Severe LV dysfunction, Severe MR and Cardiogenic shock taken up for emergency surgery. CPB was established with Innominate artery cannulation through a graft (10Fr cannula through 4mm graft) and RA cannula. In anticipation of the need for mechanical support due to poor pre-op condition, a 14Fr LA cannula was inserted through a 5mm tube constructed with bovine pericardium and stitched to LA. This was used as LV vent during the procedure and later as LV-inflow for VAD postoperatively. The left coronary button was harvested from PA with a flap, a tube was constructed along with the PA wall and implanted onto the aorta. After failure to wean off CPB, LVAD support was initiated. After ventricular recovery over next 3 days, LVAD supportof a leading Indian study determining individual factors which aggregate to mortality in one of the most commonly carried out procedures in our practice, namely Off Pump Coronary Artery Bypass Grafting.

**MATERIALS & METHODS:**

All patients who underwent Off Pump CABG at Amrita Institute of Medical Sciences, Kochi, Kerela were included in this study, excluding all On Pump cases and other valve procedures. Pre-operative risk factors are analyzed by using EUROSCORE-II \[European System for Cardiac Operative Risk Evaluation\]. A total of 800 patients were included in this study which was conducted from August 2015-September 2017.

**RESULTS:**

With a Mortality rate of 1.77%- Ventricular Arrhythmia was found to be the leading cause of death. The following factors like Uncontrolled Type II Diabetes Mellitus, Recent Myocardial Infarction, Chronic Kidney Disease and Chronic Obstructive Airway


of coronary artery disease (CAD). Adding to its superiority to vein conduits, arteries allow for a high degree of versatility and long-term patency, while minimizing the need for re intervention.

**OBJECTIVES:**

The use of total arterial revascularization (AR approach) with beating heart approach over 2 decades is compared with standard (Artery Vein approach).

**METHODS:**

From January 2002 to October 2017, a total of 1,084 patients underwent isolated off-pump coronary artery bypass graft surgery at our institution of practice. Of these 1,084 patients, 665 underwent total arterial revascularization (AR) and 419 underwent a combination of artery and vein revascularization (AVR). We compared the clinical results using the propensity score matching technique.

**RESULTS:**

2 patients in the AVR group (0.5%) and 0 in the AR group (0%) died in hospital. Multivariate analysis revealed that chronic kidneyand secondary parameters like pre-op and post-op Hb, urea, creatinine and ventilator hours, ICU stay, hospital stay and mortality.

**RESULT:**

After analysis Group-A patients required higher transfusion and re-exploration rate than that of Group-B but statistically it was not significant p-(0.92 and 0.58 respectively). Pre-op and post-op Hb, BUN, creatinine and ventilator hours was higher in Group-A patients which was not statistically significant with p-(0.83, 0.72, 0.88 and 0.92 respectively). The mean ICU stay and the mean hospital stay for Group-B was 1 or 2 days lesser than Group-A with no statistical significance p-(0.17 and 0.10 respectively) with no significant mortality rate (p-0.72).

**CONCLUSION:**

Pre op usage of antiplatelets does not have significant impact on early clinical outcome of OPCAB patients. However Group-A patients had higher transfusion rate, re-exploration and longer ICU


month and 1 year via CT angiography.

**RESULTS:**

There were 56 LIMA grafts used , 150 RSVG and 9 RA grafted. Over a period of 2 years it was observed that out of total 56 LIMA's grafted 4 had failed, Out of 150 RSVG grafted 18 had failed and out of 9 RA grafted 2 grafts had failed.

**CONCLUSION:**

In case of the coronary circulation Internal mammary artery mainly the Left internal mammary artery has the best patency rate in comparison to radial artery graft as well as the reversed saphenous vein graft. Reversed saphenous grafts had a greater graft occlusion rate in comparison to internal mammary graft and were better suited for non- LAD site for grafting and thus routinely practiced.

***Afilliations:***

^**1**^ *Department Of Surgery, Gsvm Medical College Kanpur, Kanpur, Uttar Pradesh,stenosis. Tracheomalacia, foreign bodies, intratracheal growth, amyloidosis, tracheal rings, tuberculosis constitute less common etiologies for tracheal stenosis. Stridor, dyspnea and life-threatening hypoventilation can occur in patients with tracheal stenosis. Tracheal stenosis is managed with dilatation, resection & anastomosis and tracheal stenting. Tracheal stenting is a safe and minimally invasive procedure that produces immediate relief from stridor.

**METHODS:**

Current study is a single center experience of 7 patients who underwent tracheal stenting. All patients had central airway obstruction with normal peripheral airway and lung parenchyma. Five of seven patients had locally advanced esophageal carcinoma with compression/infiltration of trachea. One patient had anaplastic thyroid carcinoma with tracheal infiltration. Another patient had post intubation tracheal stenosis. Stents were deployed with flexible bronchoscopy under fluoroscopy guidance.

**RESULTS:**

All patients had successful stent deployment and were extubated


symptoms (hemoptysis) was 28.69 months (+/- 2.1 months), and 70% of patients had symptoms for a duration of at least 2 years. The hemoptysis was classified as mild (\<100 mL in 24 hours), moderate (100-600 mL in 24 hours) and severe (\>600 mL in 24 hours) based on amount of hemoptysis. 25 (39%) patients had mild, 33 (51.5%) patients had moderate and 6 (9.5%) patients had severe hemoptysis. Out of 64 patients, lobectomy in 36 patients (56.25%), pneumonectomy in 22 patients (34.27%), bilobectomy in 3 patients (4.68%), and lobectomy + wedge excision in 3 patients (4.68%). Most common type of histology was bronchiectasis in 29 patients (45.3%), fungoma in 21 patients (32.8%), fibrocavitary disease in 9 patients (14%) and architectural distortion (destroyed lung) in 5 patients (7.8%).

There was***-A*** ***[uthors]{.smallcaps}***

*Dr Parvez Ahamed* ^*1*^

**BACKGROUND:**

Lung tumours are among the common tumours and can be benign of malignant. Benign lung tumours are less compared to the malignant types. Recognition of the clinical symptoms, types of tumours, paraclinical findings, and the treatment approaches can bring better therapeutic results. The present study aims to evaluate the characteristics, diagnostic methods, and therapeutic approaches of different benign lung tumours.

**METHODS:**

In this study 18 patients with a diagnosis of benign lung tumour were studied from 2003 to 2015. The variables were symptoms, the pulmonary location involved, surgical technique, pathology findings, recurrence, and surgery complications.

**RESULTS:**

The average age of patients was 51. Prevalence of benign lung tumours was equal in both genders. The most common symptom was cough (31%); right lung involvement was more common (72%). The


(PA) pressure measured by the Doppler echocardiography in our subset of patients after MVR. Mitral valve effective orifice area was determined by Doppler, by the continuity equation and indexed for body surface area. A study done by evaluating PPM for the valve implanted by the above criteria and post-operative regression or persistence of PA pressure, and other adverse surgical outcomes noted and inference was drawn. This study was done on 40 patients of MVR done in our institute from January 2016 to December 2016 retrospectively.

**RESULTS:**

In our study of PPM in MVR with TTK-CHITRA valves of 40 patients, 6 patients had moderate PPM as defined by Dummensil. Patients with 23 sized valve and 14% of patients with 25 sized valves had PPM. Implantation of bigger-sized valves \>25 sizes withhave used so far 8 ON-x valve in last one and half years in which 6 were in Mitral and 2 in aortic position. We encountered 2 patients with stuck valve in Mitral position after over one years of implantation. One patient had a short period of INR less than 1.7 while in other patient it was 1.9. Unfortunately both the patients died due to thrombolysis related complications as they were not willing for re do surgery. We did not encountered this problem with other mechanical valves despite longer period of low INR.

We now have the concern regarding the safety and authenticity of low INR, claimed by ON-X valve company.

***Afilliations:***

^**1**^ *Dr.KMC Foundations, St Gregorios Cardiovascular Centre, Parumala, Kerala, India*

**Three Year Single Centre Experience With Rapid Deploymnt Aortic Valve**


in each group had tricuspid valve repair and 25 didn't. All patients were followed up for 2 years with regular echocardiography.

**RESULTS:**

There was no mortality in this study.

In tricuspid valve repair group, patients with mitral regurgitation showed significant improvement in RVSP (p=0.003), RA area (p=0.04) and TAPSE (p=0.029) as compared to Mitral stenosis patients.

In no tricuspid valve repair group, patients with mitral regurgitation showed progression in mean tricuspid regurgitation grade from 2 to 2.3 while Mitral stenosis patients didn't show progression of tricuspid regurgitation grade.

**CONCLUSION:**

Mitral regurgitation patients with repaired tricuspid regurgitation show much improvement as compared to mitral stenosis with repaired tricuspid regurgitation.

***Afilliations:***

^**1**^ *U. N. Mehta Institute of Cardiology and Research Centre, Ahmedabad, Gujarat, India*

**Management of Left Sided Prosthetic Valve Thrombosis: A 3-year Tertiary Center Experience** ~*425*~

***T*** ***[heme]{.smallcaps}*** ***:ventricle injury.Redo mitral valve surgery with intermittent ventricular fibrillaion via right antero-lateral thoracotomy offers excellent exposure with less risk from re-entry associated complications.

**METHODS:**

From November 2012 to November 2017,out of 87 patients undergoing redo mitral valve replacement,13 patients underwent redo mitral valve replacement via right thoracotomy by intermittent hypothermic(28 degrees) ventricular fibrillation.Right thoracotomy was done via 4th intercostal space.Pericardium was dissected at the point of atriotomy.Aorta was not clamped.Cardiopulmonary bypass was initiated through femoral vessels and right internal jugular vein.Average age was 58.2+/8.6years.Mean ejection fraction was 50.2 +/12.8%.Previous surgeries were CABG(n=4),MVR(n=9).Mean EURO score was 9.4+/ 3.4.Time to redo surgery was 10.8+/3.5 years.

**RESULTS:**

Mitral valve replacement was done in all 13 patients(Mechanical valve -9 patients,Tissue valve-4 patients).Average intermittent ventricular fibrillation time was 38.4+/14.8 minutes and Cardiopulmonary bypass time was 74.2+/14.6 minutes.Mean


valve was implanted in 104(84.55%) patients and tissue valve was implanted in 19(15.44%) patients.Average valve size implanted was 20.6mm+/1.5 mm. Average cross clamp time & CPB time was 68.4+/12.8 minutes and 84.6 +/13.4 minutes respectively.Average ventilation time was 9.4+/3.8 hours respectively.Average ICU and hospital stay was 23.2+/4.8 hours and 6+/1 day respectively.Conversion to sternotomy was done in 1 patient due to inability to defibrillate the heart.VATS was done in 1 patient for right thoracic hematoma.There was no incidence of stroke and in-hospital mortality.14 patients were lost to follow up.Rest of 119 patients at 5 year follow up are in NYHA I.

**CONCLUSION:**

Minimally invasive AVR is as safe procedure with low per-perative morbidity,low rates of re-exploration and mortality.It need careful patient selection with major advantages of fast recovery and shortpulmonary valve function, including the capacity for growth, as an attempt to avoid the problems inherent in a right ventricle to pulmonary artery conduit unlike Nikaidoh procedure or Aortic root translocation, we have attempted to preserve aortic valve anatomy and function as an important measure to improve the patient's clinical outcome.

**CASE:**

1yr old child diagnosed to have Transposition of Great Arteries with Large Subpulmonic VSD with Pulmonary stenosis : RPA and LPA were dissected from hilum to hilum before going on CPB. After going on CPB , the MPA and Pulmonary valve was harvested out of Left Ventricle and valvotomy of PV was done which accepted Size11 Hegar dilator. Subsequently RV was incised below aorta LV was routed to aorta through combined Transatrial and Transventricular approach utilizing a bovine


slowly toward the house with Nellie a little in advance.

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useful tips, 1z0-808 Certification Answers will drag you out of the confusion andINTRODUCTION
============

The profitability of a cheese-making factory industry is based on the cheese yield capacity of the processed milk, which, in turn, depends on many factors. Since cheese is formed by a paracasein network that incorporates fat globules and milk whey, the most important and studied factors that affect cheese yield are milk casein content, casein composition and casein polymorphisms. Regarding casein polymorphism, the two widely diffuse genetic variants of κ-casein (κ-CN) are designated as A and B ([@r1]). κ-Casein B is associated with higher casein content in milk ([@r2]), and higher percentage of κ-casein in total casein than κ-casein A ([@r3]). These characteristics result in smaller micelle size ([@r4]) that, in turn, leads to improved curd properties ([@r2]) and higher cheese yield, as observed in the cheesemaking of


milk with a high somatic cell content, there is also a decrease of main milk mineral contents like phosphorus, which causes the worsening of milk coagulation properties, as reported by Summer *et al*. ([@r29]) in a research comparing milk produced by two quarters (rear or front) of the same cow: one quarter with milk somatic cell count lower and the other with higher than 400 000 cell/mL. Finally, in the present research, somatic cells ranged from 253 000 to 363 000 cell/mL; these data confirm the observation reported by Summer *et al.* ([@r21]) for Parmigiano Reggiano cheese making, also for high-moisture mozzarella, that a reduction of milk cheese yield capacity occurs starting from 300 000 cell/mL.

Difference in the milk characteristics between the two breeds
-------------------------------------------------------------

The comparison between the least      NS
  *N*(total bacterial count)/(10^3^ CFU/mL)^a^   22          34          2         \*\*

SE=standard error, NPN=non-protein nitrogen; NS=not significant (p\>0.05), \*p≤0.05, \*\*p≤0.01, \*\*\*p≤0.001

^a^Significance of differences for somatic cell count and total bacterial count is calculated on logarithmic values

According to data reported by Marziali and Ng-Kwai-Hang ([@r5]) and Walsh *et al.* ([@r4], [@r7]), who compared κ-CN AA with κ-CN BB milk, and the results of Comin *et al.* ([@r2]), who compared milk samples with different levels of κ-casein B, higher content of κ-casein B in the milk of Italian Brown cattle resulted in higher casein and protein contents. Because


g per 100 g). Similarly, Malacarne *et al.* ([@r8]) showed higher protein (3.49 *vs* 3.07 g per 100 g) and casein (2.71 *vs* 2.37 g per 100 g) contents, as well as higher total (120.76 *vs* 113.19 mg per 100 g) and colloidal (83.32 *vs* 74.25 mg per 100 g) calcium contents and higher total (97.32 *vs* 88.04 mg per 100 g) and colloidal (50.00 *vs* 44.40 mg per 100 g) phosphorus contents in the milk of Italian Brown.

Difference between the milk cheese yield of different breeds and the cheese making losses
-----------------------------------------------------------------------------------------

Least square mean values of the cheese yield and characteristics of mozzarella cheese obtained from the milk of Italian Friesian and Italian Brown breed are shown in [Table 3](#t3){ref-type="table"} and the least square mean values of cheeseyield were higher in the milk of Italian Brown than of Italian Friesian. This observation is confirmed by the similar moisture content that characterises the high-moisture mozzarella produced with both types of milk.

It must be noted that κ-casein B content influences the actual cheese yield with an effect that goes beyond the effect of the increase of milk casein content, as reported in the literature by Ng-Kwai-Hang *et al.* ([@r31]). This added effect of κ-casein B content on milk cheese yield can be explained with the lower cheese making losses of the milk from Italian Brown than from the Italian Friesian breed.

Among the cheese making losses ((*m*(cheese whey)/*m*(milk))·100), in fact, protein and casein losses were lower in Italian Brown cows' milk than in Italian Friesian ones'; moreover, the


Citrus reticulata and Citrus limon were able to drastically reduce, in a dose-dependent manner, the electrically evoked contractions of rat phrenic-hemidiaphragm. In the rabbit conjunctival reflex test treatment with a solution of essential oil of L. angustifolia, as well as linalyl acetate and linalol (30-2500 micrograms/ml administered in the conjunctival sac) allow a dose-dependent increase in the number of stimuli necessary to provoke the reflex, thus confirming in vivo the local anaesthetic activity observed in vitro.cooling dominates. When X-rays are added, the region where C$^+$ line cooling dominates is pushed to the outer part of the disk. Temperatures are much higher in the upper part of the disk, and as a result Lyman $\alpha$ cooling (black) dominates in increasingly larger regions of disk, when X-ray luminosities become larger. At the highest X-ray luminosities, we find a three-layered structure of Lyman $\alpha$ cooling, \[FeII\] line cooling, and \[OI\] line cooling. The shielded region of the disk shows a layered structure. CO ro-vibrational (red) and H$_2$O rotational cooling (green-blue) are on top. Closer to mid-plane, several smaller regions have their own major coolant, such as HCN (purple), and HNC (orange).

Vertical scale height
---------------------

Another way to show the combined effects of X-rays and FUV on the disk


due to the sharp increase of the density toward the midplane ($k_{rec} \propto n^2$): A relatively small increase in the density already compensates for larger FUV fluxes.

This picture changes quite significantly when the radiation fields also contain X-rays. The absorption of an X-ray photon by an arbitrary species creates a fast electron that can produce many ionizations, e.g., a 1 keV electron is able to produce $\sim 27$ hydrogen ionizations. As a result, the electron abundances are much higher when X-rays are included. In the unattenuated part of the disk, ionization fractions are of the order $x_e\sim 10^{-2}-10^{-1}$ (contours for $x_e=10^{-2}$ and $10^{-1}$ are indicated). They can even be higher than $x_{\rm e} > 10^{-1}$ at very small radii ($r < 0.5$ AU) and high relative heights ($z/r \gtrsim$x_{\rm H_3^+} \gtrsim 10^{-8}$. In the FUV-only case, the size of the region where H$_3^+$ is present in large abundances is smaller, and the maximum abundance is at least an order of magnitude lower compared to the models that include X-rays. It is a key species in driving ion-molecule chemistry, and so the chemistry with and without X-rays will obviously yield significantly different abundance structures.

C$^{2+}$, C$^+$, C and CO abundances {#carbon_sub}
------------------------------------

The ionization potentials ($IP$) of the species C and C$^+$ are $IP=11.26$ and 24.38 eV, respectively. While FUV photons can ionize neutral carbon, X-rays (or collisions with the resulting fast electrons) and/or cosmic rays are needed to reach a higher degree of ionization. As a result, the abundance patterns of the two species C$^+$ and C$^{2+}$ respond radically


differently to the incident radiation field on the disk. The C$^{2+}$ abundance pattern is, of course, strongly correlated with the X-ray luminosity, and C$^{2+}$ is absent in models without X-rays. The region with significant C$^{2+}$ abundances ($x_{\rm C^{2+}}>10^{-9} - 10^{-8}$) extends to larger radii and smaller relative heights for higher X-ray luminosities, simply because there is more ionizing radiation available (and not inhibited by dust, since the dominant opacity is caused by the gas). However, the FUV plays an important role in shaping the disk and therefore indirectly affects the abundance distribution as well. The bump in the total H number density (see Fig. \[model\_dens\_struct\]) extends to larger relative heights for larger FUV luminosities, thereby increasing the density at larger relative heights. This causes a larger attenuating columnincrease three to four orders of magnitude compared to the FUV-only case, even at low X-ray luminosities ($L_{\rm
  X}=10^{29}$ ergs$^{-1}$). Important to note is that the O$^{+}$ is confined to smaller radii for larger FUV luminosities, which is also the case for C$^{2+}$. This was discussed earlier in Sect. \[carbon\_sub\] and explained by the larger recombination rates due to higher densities in the upper atmosphere of the disk and the lower ionization rates due to shielding. The confinement to smaller radii is even stronger for the case of O$^{2+}$, because this species is not affected by cosmic rays.

The bottom panel of Fig. \[oxygen\_abundance\_struct\] shows the neutral oxygen abundance structure. The critical density is $n_{\rm
  crit} = 5\times 10^5$ cm$^{-3}$ for the \[OI\] 63 $\mu$m line, which is indicated by


in paper II.

OH, OH$^+$, H$_2$O, H$_2$O$^+$, and H$_3$O$^+$ abundances
---------------------------------------------------------

The water chemistry and its related species are significantly affected by X-ray irradiation. The physical circumstances in the disk change with radius $r$ and height $z$ due to radiation shielding and large differences in chemistry, which means that the X-ray and FUV energy deposition per particle, $H_{\rm X}/n$, and $\chi/n$ [with $\chi=1$ the interstellar radiation field as defined by @Draine1978; @Draine1996 and integrated between 91.2 and 205 nm], and their relative ratio change over orders of magnitude in the disk. As a result, the main chemical pathways forming the molecules OH and H$_2$O change throughout the disk and the grid.

X-rays heat the gas and therefore the reaction rates with activation barriers increase. They also drive the ionization, which enhances formation routesmaximum column density, $N_{\rm O}\sim 3 - 10\times
10^{19}$ cm$^{-2}$, is located right behind the inner rim and only varies with a factor of at most ten, which is again caused by the FUV irradiation. The width of the oxygen column density peak broadens a bit for higher FUV and X-ray fluxes. This makes the mininum in the column density less prominent in the radial column density profile. Because the column density is not very affected by radiation, it is a clean probe of the properties of a disk temperature (\[OI\] fine-structure lines), since there are no strong dependencies on uncertainties in the chemical network.

[*H$_2$O column density profile (Fig. \[H2Oradial\]):*]{} The highest water column densities, $N_{\rm H_2O}\sim 10^{20} -
10^{22}$ cm$^{-2}$, are found at the inner rim, $r\sim 0.5$ AU. As discussed, the


is given by

$$\sigma_{\rm tot}(E) = \sum_{i=1}^{N_{\rm sp}} \sigma_{i}(E) n_i/{n_{\left<{\rm H}\right>}}\qquad\rm{[cm^{2}]},$$

and $F(E,r)$ is the radiation field in unit of erg s$^{-1}$ cm$^{-2}$ eV$^{-1}$. For a given atomic species *i*, at the equilibrium, the contribution of the secondary ionization to the volumetric rate is

$$\begin{aligned}
\label{Fhy}
F_i &=& F_{\rm oth} + F_{i}^{\rm Xsec} \nonumber\\
    &=& F_{\rm oth} - {R_{i\leftarrow j}^{\rm Xsec}}\cdot n_i + R_{j\rightarrow i}^{\rm Xsec}\cdot n_j\nonumber\\
    &=& F_{\rm oth} - r_i \frac{H_X{n_{\left<{\rm H}\right>}}}{W_Hn_H} n_i + r_j \frac{H_X{n_{\left<{\rm H}\right>}}}{W_Hn_H} n_j.\end{aligned}$$

Following Eq. \[tutte\], the derivative of $F_i^{\rm Xsec}$ with respect to $n_k$ is

$$\begin{aligned}
\label{big}
\frac{dF_i^{\rm Xsec}}{dn_k} &=& -r_i \times \\ & & \left[ \frac{n_i}{W_{\rm H}n_{\rm H}}\frac{\partial \left( H_X{n_{\left<{\rm H}\right>}}\right)}{\partial n_k} - \frac{H_x{n_{\left<{\rm H}\right>}}n_i}{W_{\rm H}^2n_{\rm H}}\frac{\partial W_{\rm H}}{\partial n_k}- \frac{H_x{n_{\left<{\rm H}\right>}}n_i}{W_{\rm H}n_{\rm H}^2}\delta_{{\rm H},k}+ \frac{H_x{n_{\left<{\rm H}\right>}}}{W_{\rm H}n_{\rm H}}\delta_{ik} \right]. \nonumber\end{aligned}$$

Here weMetagenome-wide association study of the alterations in the intestinal microbiome composition of ankylosing spondylitis patients and the effect of traditional and herbal treatment.
Introduction. Ankylosing spondylitis (AS) is a systemic progressive disease with an unknown etiology that may be related to the gut microbiome. Therefore, a more thorough understanding of its pathogenesis is necessary for directing future therapy.Aim. We aimed to determine the differences in intestinal microbial composition between healthy individuals and patients with AS who received and who did not receive treatment interventions. In parallel, the pathology of AS in each patient was analysed to better understand the link between AS treatment and the intestinal microbiota of the patients.Methodology. Sixty-six faecal DNA samples, including 37 from healthy controls (HCs), 11 from patients with untreated AS (NM), 7 from


of the shepherds who were out in the fields the night the angels announced the birth of Christ. When I read the account of this in scripture it’s easy to feel excitement (from the comfort of my warm home)--but when I imagine what it would truly have been like to see an angel appear and the glory of the Lord shine all around, I probably would’ve been scared too. Definitely speechless.

I love the argument the angel presents for why the shepherds should not fear. Our Savior, Christ the Lord, had come to earth. That truth is powerful enough to dissolve any fear we face.

I know this deep in my core, but it’s tempting for me to fall into fear over and over. I’m the most susceptible to fearHarder" box, which is basically just a refrigerator box that he hits with a baseball bat." "Gets me to think harder." "Talk later?" "Yeah." " Great." "I really hope that you enjoyed your service today, and please come back..." "Okay." "Thanks a lot, big spender." "You should probably show some clavicle." "No." "I need bigger tips." "They're raising my college tuition, and if I don't come up with the money by Friday," "I got to drop out." "So I don't know what I'm gonna do." "Wow, Cece, look." "I mean, we're your friends." "If you want, I can give you money." "COACH (mumbling):" "You can give her money." "I ain't giving her a damn thing..." "I think what Coach is trying to say is that he will also


to its original orientation, zoom in, and
then rotate it again.

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BROWSE ISSUES allows you to browse through every available issue.

A FREE APP allows you to download issues to your mobile device for offline viewing. Get the Model Railroader Archive app in the iTunes and Google Play stores.

...... •. Small. square 6 Fig. 9 &2 -Tig. 8 M-K TAi;*-55*51 S.'1•1• ".6,•Maket" i. simila; - 1.1• 11FIP»111 2=.:214: 43'6'j•3, S.. J 2'* 4' frames cemented to slripwood or scribed card. 2 ends 2 1 front req'd. 8"wide * - , t . '. * I . 1810" '' .t»- -.--.. -b<..11.0 1. .- ....3 1, p. ,s,•6' ./1/once on a sheet of card using the graph post tops, and use two 4" x 6" stringers top ends of the 6" x 8" timbers and the dicated by the dotted lines on the tem- other one near the ends of the cross arm plate drawing, but they would be hard braces. 7: O'042 1 Cemen+ to end rafter- 1&6" -f»o 2%84 .:\»..... 1, /1. 1 ''. • ..541'i 10'-6' :.'.., :.h .·' .-- · 4 -•]• » Notch for Z'x to" stringer 2RS'rafters . 7 12 4 - ...·:'.1 '•I.*470 25921 lilt l-*..8'48'54 7.'0- Extend posts below deck and reinforce if desired; 442 ,. · •• <.4,63:3%& 50 · S'6··'·'·.- - .ti•t«·&..'. ' hi L.J Model Railroader Fig04210 SCALE: 3.5mm..40 Platform /2»ae.-:i' 26 ..\« --11•4**44 1.7•.4/


actual money to new players!

Normally, these poker bonuses are offered in two ways, and you'll discover that you either:

• Have an extra directly credited to your account once you sign up, or

• Get an added bonus when you first purchase your poker account

Different poker sites tend to give a different scale of poker bonus, plus some will offer you approximately $1,000 in direct poker bonuses the minute you join! On the other hand other sites may suit your first deposit on the 1:1 ratio (to a certain limit).

Regardless, the benefit of having cash credited to your account is certainly very appealing. And that is part of the reason online poker bonuses are so popular. With so many poker websites available, the competition between them is high and lotsF. to 1000.degree. F. Hot presses are generally limited to the production of flat panels either having constant or varying cross section, and autoclaves are required for fabrication of structural shapes such as tubes, hats, tees, and similar shaped structures. Thus, lack of fabrication ease limits the wide spread application of these metalmatrix materials and their benefits have not been realized to the full extent.


called the [*Gauss-Kronecker curvature*]{} of $M$, which we shall denote $GK_M$. It follows that for $M$ compact, $$\int_MGK_M\,dV_M=c_n\,{\rm deg}(G_1),~~c_n:=
{\operatorname{Vol}}(\mathbb{S}^n).$$ Furthermore, if $n$ is even, H. Hopf [@H] showed $$\label{Hopf}
\int_MGK_M\,dV_M=\frac{1}{2}\,c_n\,\chi(M).$$

Now let $M$ be an $n$-dimensional submanifold of ${\mathbb{R}}^m$. The volume form of the unit normal bundle $N_1M$ of $M$ is $dV_M\wedge
d\sigma_{m-n-1}$ where the restriction of $d\sigma_{m-n-1}$ to a fiber of $N_1M$ at $p$ is the volume form of the sphere of unit normal vectors at $p\in M$. Define the Gauss map $G_1:N_1M\rightarrow \mathbb{S}^{m-1}$ by $G_1(p,\nu)=\nu$ and let $d\sigma_{m-1}$ be the volume form of $\mathbb S^{m-1}$. Then the [*Lipschitz-Killing curvature*]{} $G(p,\nu)$ of $M$ at $(p,\nu)$ is defined to be the scalar $G(p,\nu)$ such that $$G_1^*(d\sigma_{m-1})=G(p,\nu)\, dV_M\wedge d\sigma_{m-n-1}.$$ Then $G(p,\nu)$ is exactly the volume expansion ratio of $G_1$, that is, $$G(p,\nu)=\lim_{D\rightarrowMuslims have demanded that Christian evangelist Franklin Graham be booted from yet another National Day of Prayer service, prompting officials with the National Day of Prayer Task Force to condemn as “ridiculous” the idea that religious leaders should be excluded from public events because of their faith statements.

The controversy began when the Army disinvited Graham, president and CEO of Samaritan’s Purse and
son of famed evangelist Billy Graham, from a prayer service at the Pentagon. Graham said his invitation to be
honorary chairman at the May 6 event was revoked after
Muslim members of the military complained about his description of
Islam after the 2001 terrorist attacks as “a very evil and wicked
religion.”

Muslim activists then announced they were trying to get him barred from
a National Day of Prayer event scheduled with members


Council on American-Islamic Relations, an unindicted co-conspirator in the largest terror-finance case in U.S. history, has boasted that it called for the military to remove Graham from the program at the Pentagon.

“We applaud this decision as a victory for common sense and good judgment,” Nihad Awad, CAIR’s executive director, stated. “Promoting one’s own religious beliefs is something to be defended and encouraged, but other faiths should not be attacked or misrepresented in the process.”

Graham drew the ire of CAIR with a series of comments he has made in recent years on the practice of Islam around the world, referencing the beatings of women, the “honor killings” of family members “unfaithful” to Islam and the extreme violence that has by some estimates cost millions of Christians their lives in4th Dist. No. 03CA8, 2003-Ohio-

6106, ¶5. Although a government entity might, in certain cases, be a victim of a

crime, that is not the case when the money is used to investigate a crime. “[A]

government entity voluntarily advancing its own funds to pursue a drug buy

through an informant is not one of the scenarios contemplated by R.C.

2929.18(A)(1).” Dietrich, supra. The State concedes that this is the law and does

not dispute that the trial court erred in ordering restitution to the Sidney Police

Department. Therefore, the fourth assignment of error is sustained.

       {¶7} Having found error prejudicial to the defendant, the judgment of the

Court of Common Pleas of Shelby County is reversed and the matter is remanded

for further proceedings.


suggested that the Minimal Supersymmetric Standard Model (MSSM) extended by a single $U(1)$ anomalous family symmetry spontaneously broken by non–zero vacuum expectation values (vevs) of a pair of singlet fields $\Phi,
\bar\Phi$ with $U(1)$ charges $Q=\pm 1$ can provide acceptable masses and large mixing. It was found that such a symmetry retains the above mentioned dimension-five operator which provides Majorana masses to the left-handed neutrino states. Assuming symmetric lepton mass matrices, it was shown that the neutrino sector respects an $L_e-L_{\mu}-L_{\tau}$ symmetry, implying inverse hierarchical neutrino mass spectrum, large solar ($\theta_{12}$) and atmospheric ($\theta_{23}$) mixing angles whilst $\theta_{13}=0$ and degeneracy between the first two neutrino mass eigenstates. In view of these shortcomings, it was suggested that second order effects -possibly originating from additional singlet field vevs- might lift theto acceptable results. Finally, as already noted, neutrino masses are all zero in case ($iv$) at this level, however, a second singlet with proper $U(1)_X$ charge can in principle generate also a viable $M^{\nu}$ matrix.

We will analyze in some detail case ($i$), i.e., $n' = \mbox{odd} \ ,\ m' = \mbox{even}$ and show that a viable set of lepton mass matrices and mixing naturally arise. If we write $m'=2\,p$, $n'=2\,q+1$, ${\cal A}=r+1/2$ with $p,q,r$ integers, the $U(1)_X$-charge entries of the charged-lepton mass matrix are [^2] C\_[e]{}=(

[ccc]{} 2q+1&p+q+&q+\
p+q+&2p&p\
q+&p&0\

)\[lep2\] The corresponding charge entries for the neutrino mass matrix are C\_=(

[ccc]{} 2q+r+32&p+q+r+1&q+r+1\
p+q+r+1&2p+r+12&p+r+12\
q+r+1&p+r+&r+12\

)\[Cnu2\] The parameters $m',$$n'$,$\,{\cal A}$ (or $p,q,r$ respectively), determine also the $U(1)_X$-charges of the SM particles of Table 1. A systematic search shows that a natural set of $U(1)_X$ charges is


particular case where the corresponding neutrino mass texture form respects the $L_f=L_e-L_{\mu}-L_{\tau}$ lepton flavor symmetry implying bimaximal neutrino mixing when only one singlet Higgs pair receives a non-zero vev. Contributions from the second singlet Higgs pair vev break the $L_f$ symmetry and generate new mass entries leading to acceptable neutrino masses and mixing. A numerical analysis, confirms that for natural values of the –yet undetermined by the theory– Yukawa couplings, there exist solutions satisfying all experimental constraints.

Acknowledgements {#acknowledgements .unnumbered}
================

[*This research was supported by the program ‘HERAKLEITOS’ of the Operational Program for Education and Initial Vocational Training of the Hellenic Ministry of Education under the 3rd Community Support Framework and the European Social Fund, and, by the European Union under contract MRTN-CT-2004-503369.*]{}

[99]{}

S. Fukuda [*et al.*]{} \[Super-Kamiokande Collaboration\], “Tau neutrinos favoredQ:

Automate Google Searching of Terms in Different Tabs

I have a list of terms, each on a new line.
I need to Google search each one.
I have been copy and pasting each term invidivually into a new tab, but I was wondering if there was a way to automate it.
What is the easiest way to open a new tab for each term and search in on Google?
(I am on OSX. If any browser has an easy solution, I don't mind using it, but prefer Chrome if it doesn't matter.)

A:

First, save the following code to a file:
<html>
<head>
<title>MultiSearch</title>
<script>
function search()
{
    var queries = document.getElementsByTagName('textarea')[0].value.split(/[\r\n]/);
    for(var i = 0, j = queries.length; i < j; i++)
        if(queries[i])


Q:

Full width drop-down menu regardless of hovering position Bootstrap

Currently I am using this mega menu

http://demo.shymarkets.com/codecanyon/mega/model-1/css/index.html

I need a full width drop-down menu regardless of hovering position.
Firstly, let me show you what I am hovering on a drop-down menu item.

As you can see, when I hover on '4 COLS' it doesn't cover whole container. The left side of the drop-down menu is missing.
I want it to be full width regardless of hovering position.
I achieved that by changing a value in custom.css file.

http://demo.shymarkets.com/codecanyon/mega/model-1/css/css/custom.css

/* drop-down menu */
.dropdown-menu {
  position: absolute;
  top: 100%;
  **left: -1px;**
  z-index: 1000;
  display: none;
  float: left;

By changing left: -1px to left: -120px I got what I want

However, this time it is neither something dynamic nor probably responsive.
I suppose, the width ofto a certain submenus only, add a custom class selector (e.g.: full-width) on line 2:
    $('.nav').on('mouseover', '.dropdown.full-width', function() {

Change line 7 to:
        $('.full-width .dropdown-menu').each(function() {

Apply the custom class to your menu item:


[contents] =>

ACTwebDesigns

helllllllo

ACTwebDesigns

sds

ACTwebDesigns

Sponge

dick

ACTwebDesigns

arghh

    )
)

Any help very much appreciated.

A:

Well since you are using jQuery already you could use the each function:
$.ajax({
        type: 'POST', url: './', data: 'token=' + token + '&re=8', cache: false, timeout: 5000,
        success: function(html){
            auth(html);
            var JSON_array = eval(html);
            CodingStateMachine(ISO2022JPSMModel),
            CodingStateMachine(ISO2022KRSMModel)
        ]
        self.reset()

    def reset(self):
        CharSetProber.reset(self)
        for codingSM in self._mCodingSM:
            if not codingSM:
                continue
            codingSM.active = True
            codingSM.reset()
        self._mActiveSM = len(self._mCodingSM)


"the best damn barman from Timbuktu to Portland, Maine... and Portland Oregon for that matter". But Lloyd isn't real. He's just a figment of Jack Nicholson's imagination, an imagination living in a brain that has gone very, very wrong. After being cooped up for too long in a hotel, a hotel that doesn't even have Wi-Fi or rolling Sky Sports News, he goes completely hat-stand, chasing his wife around the place with an axe.

Come on, we've all done it.

3) Mean Streets

Mean Streets is the film that hailed Martin Scorsese a "made man" in the world of cinema. Filmed in muted colour and almost entirely with a handheld camera, it broke new ground in cinematography and boasts three great bar scenes.

An early example of the slow-motion shot, Scorsese followsa young Robert De Niro into a brooding, red-lit bar that critics likened to Dante's Inferno. With two broads on his arm and a cool hat on his head, and to the tune of "Jumpin Jack Flash" by the Stones, it's a lesson on how to enter a drinking establishment. Then there's a classic bar fight (it's actually a pool hall, but quit busting our balls) where De Niro does over some douchebags in superbly shambolic fashion.

Advertisement

Yet both of the above are narrowly eclipsed by Harvey Keitel's close-up, 90-second descent into a serious drunk funk, accompanied by the Chips' doo-wop favourite "Rubber Biscuit". Most of us remember how he feels. Or not, as the case may be.

4) Withnail & I

You may remember the summer of 2005 when Magners


planned by Symbian Ltd. However users could not install their own software on the device.

The display was a black and white touchscreen, partially covered by a flip which, when opened, reveals a large wide display. For that reason it can be considered the clear forerunner of the popular P800/P900 series of smartphones. It predates the UIQ user interface which runs on those later phones, but again, the heritage is clear.

The phone and the software was developed at Ericsson's lab in Kista, Sweden. The UI was developed at Ericsson's Software Applications Laboratory in Warrington, UK. The UI was built using an in-house developed library called the Ericsson Control Kit (ECK).

The device was delivered in three variants. The most common being the R380s (dual 900/1800 GSM bands) and the (rarer)[Clinical investigation of chronic blepharitis and evaporative loss dry eye].
To investigate the relationship between chronic blepharitis and evaporative loss dry eye. Forty-one patients (82 eyes) were diagnosed as chronic blepharitis from November 2002 to April 2003 in Beijing Tongren Eye Center, of which 22 cases were male and 19 female. All patients' ocular surface was judged by Schirmer I test, tear film break up time (BUT) and Tearscope. Meibomian gland secretion was used for bacteria culture and antibiotic sensitivity test. Thirty patients (60 eyes) of glaucoma, cataract and LASIK before surgery were used as control, which included 16 male and 14 female. Microbiological results of meibomian gland secretion were compared and the statistical difference was evaluated by chi(2) test. Of the blepharitis group, ST value was less than


America. That claim, however, is patently and demonstrably false when the Pew Research Center study the group cites, without attribution, is considered.

The study defines the terminology of the large group of millennials as "religiously unaffiliated." They remain religious, but are increasingly less institutionally religious – departing traditional denominations for loose attachments or no attachment to a named church. The survey claims, however, that those who abandon a denomination are more likely to return to a church later in life. It also notes that most "nones" still believe in God, heaven and hell.

The same survey claims "unbelief" has increased by 3 percent in recent years. However, 89 percent of Americans still claim to believe in God.

According to the FFRF letter, freethinkers, atheists and agnostics are subject to "reprehensible prejudicehave your managers get a DBA who knows their business!
Note: Our system has been in place for 10 years now. It hasn't been built in a day...

A:

100 million rows daily?
You have to be realistic. I doubt any single instance of any database out there can handle this type of thouroughput efficiently.  You should probably look at clustering options and other optimising techniques such as splitting data in two diffent DB's (sharding).
MySQL Enterprise has a bunch of features built-in that could ease and moniter the clustering process, but I think MySQL community edition supports it too.
Good-luck!


PRESS

Saturday, May 19, 2012

PREPARING FOR SUMMER

Weekend woehoee! This is gonna be a lazy weekend for me.
Thursday I had a party in Utrecht and had a great time! There was only one
disliking thing and that was the Friday morning. The alarm was waking me
up to early for another internship day. I’m so tired so this is a weekend with
much sleeping and relaxing. And what are your plans so far? Tell me!

The sun is finally shining here and the temperature is
around the 20 degrees so the weather is finally better. I can dump my jacket for
now and can preparing myself for the summer, hmmm love it! Today we put the
boat in the water and I really can’t wait to use it, the first signs for the
summer are present!
Enjoy
your weekend mythe real *summer*, weather out there is still very crazy, what are your plans?

Hello Floortjes, thank u so much for your comment on my blog! I really like yours too, and those pants you're wearing are adorable. Let's follow each other??http://fashionfauxpas-mintjulep.blogspot.com

these pictures are unbealiveable! are super! wow! i adore your blog! what about keep in touch? come to see mine, and if you like it, we could follow each other! what do you think? kisse kissemiriam stella fashion blogger

You look so beautiful :) I love the whole outfit and your sandals are so adorable :) This reminds me that I need to buy new sandals :) You have a really lovely blog sweetie :)Thank you for stopping by my blog :)

Hello! After visiting your blog, I invite you


Increased adrenomedullin protein content and mRNA expression in human fetal membranes but not placental tissue in pre-eclampsia.
The relationship between Pre-eclampsia (PE) and placental production of Adrenomedullin (AdM) is not completely understood. This study measured placental and fetal membrane AdM protein concentrations by specific radioimmunoassay and mRNA expression by Northern blot analysis in samples obtained at either term or preterm gestation from women either in labour or not in labour. Samples were obtained from women with normotensive and pre-eclamptic pregnancies. There were significant increases in immunoreactive AdM protein concentration (pg/mg DNA) in choriodecidua and amnion of women with PE compared to normal pregnancy for the preterm not-in-labour group (choriodecidua: control 124 +/- 16, n = 10, PE 361 +/- 35, n = 10; amnion: control 94 +/- 12, n const buffer: any[] = [];
    const thenHandlerFactory = (
      remainingPromiseFactories: Array<() => Promise<*>>,
    ) => (value: any) => {
      buffer.push(value);
      if (remainingPromiseFactories.length > 0) {
        // prettier-ignore
        return remainingPromiseFactories[0]()
          .then(thenHandlerFactory(remainingPromiseFactories.slice(1)))
          .catch(catchHandler);
      }
      return resolve(buffer);
    };
    const catchHandler = error => {
      reject({ error, buffer });
    };
    //


(1992) for $BVR$ and the most recent calibrated ${{z^\prime}}$ catalog from D. Tucker (private communication).

The Mosaic cameras provide 8k $\times$ 8k pixels subtending 0.257[[$^{\prime\prime}\,$]{}]{} each, for a 35[[$^\prime\,$]{}]{} square field. Each 35[[$^\prime\,$]{}]{}“subfield” of the survey is imaged with 20 dithered exposures in each filter, with dithers up to 200[[$^{\prime\prime}\,$]{}]{} to provide good flatfielding. Adjacent subfields will be stitched together into full 2$^\circ$ fields after all the contiguous data have been acquired, but for now coaddition and analysis takes place on a subfield-by-subfield basis. For this paper we are considering one particular subfield which has been completed, centered at 10:54:43 -05:00:00 (J2000). Several other subfields have been completed, and shear-selected clusters tentatively identified, but this cluster is the first to receive spectroscopic confirmation. This is due to the presence of the likely< z_{\rm
spec} < 0.36$ from the 2dFGRS public data (Colless [[*et al. *]{}]{} 2001). Thus the full spectroscopic sample for this 35[[$^\prime\,$]{}]{} subfield contains 71 galaxies in the range $0.04 < z_{\rm spec} < 0.98$. Like many other authors, we measure the difference between photometric and spectroscopic redshifts in terms of the quantity $\delta z = (z_{\rm
spec} - z_{\rm phot}) / (1 + z_{\rm spec})$, which is just the percentage error in the quantity $1+z_{\rm spec}$. This encodes the fact that a redshift error of a given size is more important at low redshift than at high redshift.

Figure \[fig-zphot\] shows a scatterplot of $\delta z$ versus $z_{\rm spec}$. The rms value of $\delta z$ is 0.065, and the range is $-0.16 < \delta z < 0.16$. This per-galaxy accuracy is sufficient for


and extend up to $z\sim 1$ (Tyson [[*et al. *]{}]{} 2003). Furthermore, using the observed $\gamma_t(z_{\rm
phot})$ relations, we have identified the redshift of the [*lens*]{} in addition to that of the cluster, and found that they are consistent. Thus any dark clusters which might be found in the DLS can be assigned rough redshifts and masses, a necessary first step in investigating them, as well as including them in cluster-counting cosmological tests.

The mass of the cluster is fairly high, but by no means exceptional. Some examples of more massive clusters at this or higher redshift are MS1054-03 at $z=0.83$, with a velocity dispersion of $\sigma_v = 1170$ km s$^{-1}$ (Tran [[*et al. *]{}]{} 1999) and $\sigma_v = 1311$ km s$^{-1}$ inferred from weak lensing (Hoekstra [[*et al. *]{}]{} 2000), and CL1604+4304 at $z=0.90$, with$\sigma_v \sim 1200$ km s$^{-1}$ (Postman, Lubin & Oke 2001). This suggests that even at high redshift, the DLS is sensitive to clusters over a significant range of the mass function. However, any conclusions as to the nature of the overall DLS sample would be entirely premature. This cluster may not be representative, as the large arc was a significant factor in choosing to investigate this cluster first.

The M/L of this cluster is very high, but examples of darker clusters can be found. For example, Fischer (1999) found $M/L_R = 640 \pm 150$ for MS12247+2007, consistent with the earlier measurement of Fahlman [[*et al. *]{}]{} (1994) on the same cluster. Whether shear-selected clusters tend to be [*systematically*]{} underluminous (or more accurately, whether optically-selected clusters tend to be overluminous) is a


is whether shear-selected clusters tend to be X-ray underluminous. This and other shear-selected clusters from the DLS are currently being followed up with [*Chandra*]{} and [*XMM*]{} X-ray imaging.

A cluster of this mass is not unexpected in the volume probed by these data (Rahman & Shandarin 2001), so the number of clusters in the complete DLS could be estimated by scaling up the area sampled here, yielding $\sim$60. However, that is a lower limit because we chose only the single most dominant mass concentration in this area. Preliminary analysis of full-depth areas suggests that about 200 clusters will be found in the DLS. The tightness of constraints on cosmological parameters afforded by a sample of this size, with and without priors from other measurements such as the cosmic microwavebackground, are being computed (Hennawi & Spergel, in preparation).

We thank NOAO for supporting survey programs, and the 2dFGRS project for making data publicly available. Observations were obtained at Cerro Tololo Inter-American Observatory and the W. M. Keck Observatory. CTIO is a division of National Optical Astronomy Observatory (NOAO), which is operated by the Association of Universities for Research in Astronomy, Inc., under cooperative agreement with the National Science Foundation. The W.M. Keck Observatory is operated jointly by the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. This work also made use of IRAF and of the NASA/IPAC Extragalactic Database.

Bartelmann, M. & Schneider, P. 2001, [*Phys. Rep.*]{} 340, 291

Beers, T. C., Flynn, K. & Gebhardt, K. 1990,  100, 32

Ben[í]{}tez, N.  2000, , 536,


       END LOOP;
        CLOSE c_category;

        SELECT DISTINCT tmp_csv.cvalue FROM tmp_csv WHERE tmp_csv.cvalue NOT IN ( SELECT category.id FROM category );
        DROP TEMPORARY TABLE IF EXISTS tmp_csv;
    END //

DELIMITER ;

I'm not 100% certain as to how robust it is but it was working with your data on my dev box.
You specify the delimiter for your CSV data when you call the procedure thus:
CALL `check_subcats`(',');

Essentially this loops through the category table to read sub_cat. It then splits the sub_cat value into chunks using the delimiter provided (much like PHPs explode() function) and writesevery one of those values to a temporary table.
This then gives you a temporary table holding all your CSV data in individual bits and it's then a simple matter of selecting everything from that data that's NOT IN the category.id list.


initial velocity dispersion. The existence of these particles has been demonstrated through their gravitational effects on the largest (galactic to cosmological) scales of the Universe. Collectively, they are successfully modeled as Cold Dark Matter (CDM), a crucial component of the [$\Lambda$CDM ]{}concordance model.

Although a plethora of concrete DM models have been proposed [@Bertone:2004pz], dedicated direct and indirect astrophysical searches have yielded no convincing evidence for a DM particle so far. The strongest exclusion limits in the mass vs cross-section plane using direct detection through nuclear recoil come from the Xenon1T experiment [@Aprile:2019jmx; @Aprile:2019xxb; @Aprile:2018dbl; @Aprile:2019dbj]. Meanwhile, possible signals of DM annihilation resulting in the positron excess detected by the Alpha Magnetic Spectrometer (AMS) instrument [@AMS02-positron_excess] are in conflict with the Planck collaboration [@Aghanim:2018eyx] observations of the Cosmic Microwave Background (CMB) anisotropies,and velocity perturbation $\theta_g$ are given by

\[GDMperts\] $$\dot{\delta}_g = 3  H \left( w \delta_g  - \Pi_g\right) -  (1+w) \left[ \frac{k^2}{a}\theta_g+ \frac{1}{2} \dot{h} \right]
\label{fluid_delta_equation}$$ $$a \dot{\theta}_g = -(1 -3 c_{a}^2)     aH   \theta_g
+  \frac{\Pi_g}{1+w}
-  \frac{2}{3}  k^2 \Sigma_g \,.
\label{fluid_theta_equation}$$ with $ c_a^2 = \dot{{\ensuremath{\bar{P}}}}_g/\dot{{\ensuremath{\bar{\rho}}}}_g$. While the above equations are generically valid for any conserved fluid, the following special choice of closure equations, defines the GDM model [@Hu1998a] $$\begin{aligned}
  \Pi_g &= c_s^2 \delta_g+3 (1+w) ( c_s^2 - c_a^2 )  aH  \theta_g  \\
\dot{\Sigma}_g  &=  - 3 H   \Sigma_g+ \frac{4}{1+w} {\ensuremath{c^2_{\rm vis}}}(\frac{\theta_g}{a}  - \frac{1}{2}\dot{\nu})\,.
\label{ShearGDMeom}\end{aligned}$$

The first equation is a perturbative EoS for the pressure perturbation $\Pi_g \equiv (P_g- {\ensuremath{\bar{P}}}_g)/ {\ensuremath{\bar{\rho}}}_g $ and the second


equation is an evolution equation for the scalar part $\Sigma_g$ of the traceless part of the GDM stress tensor $T_g^i{}_j$. We refer the interested reader to [@KoppSkordisThomas2016] for further discussions of the theoretical motivation, physical interpretation and notation.

The EoS $w$ is expected to be uncorrelated with the two perturbative parameters $c_s^2$ and ${\ensuremath{c^2_{\rm vis}}}$ during the era of matter domination, as shown in [@ThomasKoppSkordis2016]. However, as we show below, these parameters become correlated during the era of radiation domination, when adiabatic initial conditions are considered.

Smooth bin parametrization
--------------------------

In order to constrain the three purely time-dependent GDM parametric functions $w(a)$, $c^2_s(a)$ and ${\ensuremath{c^2_{\rm vis}}}(a)$ in a way that is sufficiently general but still feasible, we restricted the variation of these functions to $N=9$ scale factor bins. The bin edges werechosen to be $$\begin{aligned}
\tilde a_0 &=1 \notag\\
\tilde a_{1\leq i\leq N-1} &= 10^{- i \Delta_{\ln a}}~~\mathrm{with}~~\Delta_{\ln a}=0.5\\
\tilde a_{N} &= 0  \notag\end{aligned}$$ so that $f(a)$ (here denoting any of $w$, $c^2_{s}$, ${\ensuremath{c^2_{\rm vis}}}$) has piecewise constant values between them, that is, $$\label{sharpbins}
f(a)= \sum_{i=0}^{N-1} f_i \Theta(a-\tilde a_{i+1}) \Theta(\tilde a_{i}-a)\,,$$ with the $f_i$ coefficients comprising $N$ free parameters and $\Theta$ is the Heaviside step function. In the case of the $w(a)$ function, the discontinuity at the bin edges $\tilde a_{1\leq i\leq N-1}$ implies $c^2_{a,i}(\tilde a_i)= \pm \infty$ for the adiabatic sound speed. In order to test whether our conclusions depend on this discontinuity, we regularized the transitions by a lognormal smoothing of Eq.  with width $\sigma_{\ln a}$ (and assuming $\sigma_{\ln a} \ll \Delta_{\ln a} $), leading to $$\begin{aligned}
 \label{smoothbins}
f(a) &= \sum_{i=0}^{N-2}