depend on the size parameter $R$ of the bound quark. For our “canonical” set of parameters, $g_A=1.25$ and $R=0.6 \pm 0.05$ fm, used in the calculations of nucleon electromagnetic form factors and meson-baryon sigma terms [@PCQM] we obtain: $$\begin{aligned}
& &f_1 = -19.5 \pm 1.6 \,\,\, \mbox{MeV}, \hspace*{1cm}
   f_2 = -8.7 \pm 0.7 \,\,\, \mbox{MeV}, \\
& &f_3 = 18 \pm 1.5 \,\,\, \mbox{MeV}, \hspace*{1.6cm}
\frac{f_1}{f_2} = 2.2 . \nonumber \end{aligned}$$ Using these values of $f_1$ and $f_2$ we can estimate the isospin-breaking correction to the energy shift of the $\pi^- p$ atom in the $1s$ state. The strong energy-level shift $\epsilon_{1s}$ of the $\pi^- p$ atom is given by the model-independent formula [@piP-atom]: $$\begin{aligned}
\epsilon_{1s} = \epsilon_{1s}^{LO} +  \epsilon_{1s}^{NLO} =
\epsilon_{1s}^{LO} (1+\delta_{\epsilon}) .  \end{aligned}$$ where theexplicit Weinberg-Tomozawa (WT) term. This connection is based either on an unitary transformation of the quark fields, which leaves the unperturbed part of the Lagrangian unaltered, or by the explicit evaluation of observables, such as the low-energy $\pi N$ $S$-wave scattering amplitude.

As an intermediate result we note that:

i\) the PCQM has two Lagrangian manifestations, where, as a matter of calculational convenience, either version can be used in the perturbative evaluation.

ii\) the full equivalence between two model versions is only given, when the full quark propagator is introduced; hence a truncation of the intermediate-state sums will lead in general to different results.

iii\) the connection between pseudoscalar and axial vector pion-quark coupling is made explicit; in the context of the PCQM this relation is established since the quarks remain on


Does 16 divide m(-3)?
True
Let g(p) = 4*p**2 - 34*p + 934. Is 50 a factor of g(51)?
False
Suppose -5*v + 5*p + 94734 - 16464 = 0, -2*v - 4*p + 31314 = 0. Is 3 a factor of v?
False
Suppose 6*g = 432 - 432. Suppose -17*u + 267 + 1212 = g. Does 7 divide u?
False
Suppose 8*v + 3*v = -1727. Let r = v + 261. Does 52 divide r?
True
Let p(v) be the third derivative of 69*v**5/10 - v**4/12 - 2*v**2. Does 44 divide p(-1)?
False
Let r = -12 + 15. Suppose -5 + r = -i. Suppose 0 = -3*t + i*t + 180. Is t a multiple of 36?
True
Suppose 0 = 2*x + 212 + 104. Let q = 180 + x. Is q a multipleof 33?
False
Let a(c) be the third derivative of -c**5/20 - c**4/2 + 3*c**3/2 + 2*c**2 + 7*c. Is 2 a factor of a(-4)?
False
Suppose -35*l - 10053 = -57513. Suppose 2*p - 3*m - l = -p, -2258 = -5*p + 4*m. Is 25 a factor of p?
True
Let d = -14 + -173. Let b = 33 - d. Is b a multiple of 22?
True
Suppose 14*m + 11*m - 415872 = 13*m. Is 68 a factor of m?
False
Suppose -w - 5*n = -754 - 1954, 10851 = 4*w + n. Does 57 divide w?
False
Suppose 76215 = 17*n - 89035 - 16157. Does 9 divide n?
False
Let n(l) = 265*l - 4771. Is 3 a factor of n(44)?
False
Let p be 2/(19/17 - 1). Let o = -2387 + 2385. Is 3*2/o


N-type differential pair, the operational amplifier 10 cannot achieve rail-to-rail structure and the input common mode range of the operational amplifier is smaller. In addition, if the input stage of the operational amplifier 10 is the N-type differential pair, the performance of the noise, slew rate and the unity-gain frequency of the operational amplifier degrade.
Another method for preventing the additional current feeding into the input stage 100 is using high voltage devices to achieve the operational amplifier 10 and coupling the body of the PMOS P_IN, P_IP to the highest voltage of the operational amplifier 10 (i.e. voltage VCC). However, using the high voltage devices increases cost of the integrated circuitry. In addition, the performance of the high voltage devices is poorer and the noise of the highHome defended against liability on the ground that Sunshine's insurance policy was voided because Sunshine's shareholder-employees made materially false statements to American Home concerning Sunshine's financial state and the whereabouts of various shareholder-employees on the night of the fire.  American Home is presumably relying upon its contract provision that states:

31
This entire policy shall be void if, whether before or after a loss, the Insured has wilfully concealed or misrepresented any material fact or circumstance concerning this insurance or the subject thereof, or the interest of the Insured therein, or in case of fraud or false swearing by the Insured relating thereto.

32
At the close of the evidence, the district court struck American Home's defense as to the misrepresentations in the shareholder-employee statements for insufficient evidence.  American Home


claim for losses under the policy and American Home's defense of fraudulent exaggeration of the proof of loss are so interwoven with those of the arson defense that justice demands a retrial of these issues together.   See Gasoline Prods.  Co. v. Champlin Refining Co., 283 U.S. 494, 500, 51 S.Ct. 513, 515, 75 L.Ed. 1188 (1931).  Sunshine's financial history, profitability, and solvency were relevant to this claim and these defenses.

46
As to the other claims and defenses that were raised at trial, we do not believe that the facts underlying those issues are so interwoven with the facts relevant to arson as to automatically require a new trial.  Because we found no other reversible error, we do not remand those issues.

VII.

47
The judgment of thesynchronous motion with the electrode. When the vibrating element is at rest, it is disposed in a plane substantially parallel to the plane of a base plate.
U.S. Pat. No. 4,720,682 to Ikushima et al. discloses a surface electric potential sensor for detecting the potential on a surface in a non-contacting fashion. The sensor consists of a tuning fork, a piezoelectric vibration element mounted on each leg of the tuning fork, at a position near a base of the tuning fork, for vibrating the tuning fork, an insulating substrate mounted on a free end of each leg of the tuning fork, a conductive film provided on the insulating substrate, a board for supporting the tuning fork, and a shield case for encasing the tuning fork.
U.S. Pat. No. 4,625,176 to


counting bacteria using this method is labor intensive and can take several days due to the necessary time for culture. Secondly, the method is not able to count dead bacteria. Lastly, competitive growth makes counting of slow growing species difficult. Alternatively bacteria, particle or eukaryotic cell samples can be manually counted using a microscope^[@CR13]^. Although automated image processing techniques have replaced manual counting^[@CR14]--[@CR16]^, the method is still prone to error. Especially irregular-shaped samples or large aggregates are difficult to count accurately using optical methods. These advantages can be countered by dividing the sample using an array of microwells, cells can be counted by first recognizing the microwells by image recognition, and then the individual cells within the wells^[@CR17]^. While this method is fast and reliable, it requires images(PCR), also known as digital PCR (dPCR), is becoming widely applied due to its accurate determination of initial DNA concentrations^[@CR24],[@CR25]^. The method is based on dividing a sample into several subsamples in such a manner that each subsample contains less than one molecule of DNA on average. The sample is analyzed by PCR and the subsamples showing amplification are determined. Finally, the initial DNA concentration can be determined with great accuracy using Poisson statistics. This method can further be used to count DNA labelled nanoparticles^[@CR26]^. In this paper we describe a novel method for counting micrometre sized particles or cells using a microwell array. Similar to dPCR, the sample is divided into several sub samples by the microwell array, microscope images of the well array are taken and


For the third device, a PDMS particle prevented complete sealing of the microwell array to the glass slide in the top right corner. Through this, the solution from some of the wells in panel 5, 6, 11, and 12 was withdrawn when removing excess solution after filling. To remove variations from well filling, devices with entrapped air bubbles, missing microwells or other defects decreasing the filling efficiency below 99% were removed from further analysis.Figure 1Design of the PDMS microwell array chip. CAD drawing of the entire microwell array chip, containing 36 individual panels (**A**). Drawing of an individual panel, containing 900 microwells in a 30 by 30 square arrangement (**B**), and photograph of the produced PDMS microwell array (**C**).

A Poisson model was used to simulate the influence ofmicrowell number and volume on the counting performance of the device (Fig. [2](#Fig2){ref-type="fig"}). Under the assumption of a Poisson distribution of particles into the wells, the number of microwells has no influence on the dynamic range of the device. However, the number of microwells is an important factor to affect the confidence interval of the measurement (Fig. [2A](#Fig2){ref-type="fig"}). The higher the number of microwells is analyzed, the smaller confidence interval is obtained. In a second simulation, the influence of microwell volume was analyzed (Fig. [2B](#Fig2){ref-type="fig"}). The microwell volume is an important factor influencing the range of number densities that can be measured by the device. While small microwells allow for the determination of high number densities in excess of 10^6^ particles/µL, wells with nanoliter volumes would allow counting of ten or less


also demonstrated with *E*. *Coli* and *HeLa* cultures (Fig. [7](#Fig7){ref-type="fig"}). Due to the high light transmittance of cells, a clear classification of unoccupied and unoccupied wells was more difficult. To allow for easier classification cells have to be stained first using a dye, such as Trypan blue (Fig. [7C](#Fig7){ref-type="fig"}), in which case analysis can be conducted as previously done with microparticles. Alternatively, the cells can be marked fluorescently, as done with the GFP expressing HeLa cells (Fig. [7A](#Fig7){ref-type="fig"}), or by using a fluorescent dye, such as BacLight Green Bacterial Stain (Fig. [7C](#Fig7){ref-type="fig"}). As the classification of wells into the two groups is dependent on the staining of the cells, the accuracy for the cell counting is also dependent on an efficient cell staining protocol. When a fluorescent dye is used, the emissiondistribution into the wells is valid at higher number densities compared to microparticles.Figure 7Determining of number densities of cells. Fluorescent microscopy image of a single panel filled with GFP labeled HeLa cells (**A**). Histogram of well intensity for all 36 panels, determining the number of GFP labeled HeLa cells (**B**). Microscopy images of a single panel containing unlabeled (left), Trypan Blue labeled (middle), and fluorescent labeled *E*. *Coli* (right, **C**). Bar diagram of determined number densities of *HeLa* cells and *E. Coli* stained using Trypan blue and fluorescent staining (blue), and comparison to commercial cell counter (red, **D**).

Conclusions {#Sec11}
===========

We demonstrated a new method for determining the number density of microparticles or cells using Poisson statistics and microwell arrays. The method is able to accurately determine the number density


Monday, July 9, 2012

A Little Blue to Brighten Your Day.

As I was getting ready to put together one of my more favorite breakfasts, it struck me that I should be sharing this with all of you! Especially now that fresh blueberries are gracing the stands of local farmer's markets.

This bowl of deliciousness is a snap to prepare, is nutritious, and will keep you feeling satisfied well in to your day. I can't think of anything better than that!

There isn't even a title for the recipe. If you have a clever idea let me know. :) Here's what's in it:

1. For one serving, put half of a container of Butler Farm's ricotta cheese in a bowl. Her containers look to be about 8 oz.

Butler Farms is the first licensedmixing a 1/2 tsp of the dried zest in to your small container of ricotta and letting it sit over night.

3. Drizzle a tablespoon or so of real maple syrup over the top.

Please, for the love of all things holy, if you don't have real maple syrup in your pantry, dispose of the imitation liquid that you do have and pick up some real Wisconsin Maple syrup. If you read the ingredients on your imitation syrup you may be shocked to see that it contains NO actual maple syrup! You can find real maple syrup everywhere, including nearly every farmer's market in the state. This was a rough year for maple syrup harvesting due to the warm winter and early spring, so supplies may dwindle sooner than later.


another so-called stimulus package, which would do very little to grow the economy. And his proposal to finance the package with higher taxes on oil would raise oil prices directly and by reducing exploration and production.

We are equally concerned with his proposals to increase tax rates on labor income and investment. His dividend and capital gains tax increases would reduce investment and cut into the savings of millions of Americans. His proposals to increase income and payroll tax rates would discourage the formation and expansion of small businesses and reduce employment and take-home pay, as would his mandates on firms to provide expensive health insurance.

After hearing such economic criticism of his proposals, Barack Obama has apparently suggested to some people that he might postpone his tax increases, perhapsto 2010. But it is a mistake to think that postponing such tax increases would prevent their harmful effect on the economy today. The prospect of such tax rate increases in 2010 is already a drag on the economy. Businesses considering whether to hire workers today and expand their operations have time horizons longer than a year or two, so the prospect of higher taxes starting in 2009 or 2010 reduces hiring and investment in 2008.
In sum, Barack Obama’s economic proposals are wrong for the American economy. They defy both economic reason and economic experience.


CLEVELAND, Ohio -- Weren't calamity and dysfunction in Berea supposedly put on notice when the Big Show arrived? Now that nickname feels more ironic than anything.

Big Show? Mike Holmgren gave up the stage and his claim to the marquee when he decided he wasn't going to return to the sidelines. Coaching is what he did best. Did he have to become the mystery man behind the curtain?

Didn't owner Randy Lerner deem the need to overhaul the organization's credibility almost as important as fixing the endlessly flawed football operation? Isn't that why Lerner gave some consideration to the idea of hiring Mark Shapiro once upon a time?

Even if Cleveland sports fans don't recognize it, Lerner saw how the Indians have done it right under Shapiro; how they dealt professionallythe adaptor protein ASC, and caspase-1. Activation of the inflammasome leads to the homotypic interaction of the PYD (pyrin domain) of NLRP3 and ASC proteins that cleaves and activates caspase-1, followed by the processing of the inactive proinflammatory cytokines IL-1*β* and IL-18 to their active forms that trigger downstream inflammatory response \[[@B7]\]. Caspase recruitment domain-containing protein (CARD) 8, also known as TUCAN (tumor upregulated CARD-containing antagonist of caspase nine), interacts physically with caspase-1 and negatively regulates caspase-1-dependent IL-1*β* expression and nuclear factor- (NF-) *κ*B activation. The NLRP3 inflammasome plays a role in the pathogenesis of numerous inflammatory and autoimmune diseases such as diabetes, obesity, and atherosclerosis \[[@B8], [@B9]\].

Single nucleotide polymorphisms (SNPs) are the most abundant types of DNA sequence variation in the human genome. SNPs provide a well-established


method for analyzing complex gene-associated diseases and individual susceptibility for some disorders. Polymorphisms in NLRP3-associated genes are linked to common immune inflammatory diseases \[[@B10]--[@B12]\]. The SNP of CARD8 rs2043211 changing cysteine at codon 10 to a premature termination codon (c.30T\>A; p.C10X) in this gene was found to be associated with the inflammatory activity in early rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) \[[@B13], [@B14]\]. A common insertion (ins)/deletion (del) promoter polymorphism (-94ins/del ATTG polymorphism) of NF-*κ*B seems to be related to several inflammatory diseases such as ulcerative colitis (UC), Graves\' disease, and psoriasis vulgaris \[[@B15]--[@B17]\]. Polymorphisms of the IL-18 gene have been shown to influence some chronic inflammatory diseases including diabetes, RA, systemic lupus erythematosus (SLE), and IBD \[[@B18]--[@B21]\]. The SNP of IL-1*β*-511T\>C has been associated withwas found among the genotypes on megakaryocyte count, disease severity, or drug response. There is no sufficient evidence that the NF-*κ*B-94ins/del ATTG polymorphism can be regarded as the prognostic factor. Moreover, the frequency of the W allele was significantly greater in female ITP patients compared to male ITP patients, and its potential mechanism needs to be clarified in the future. Platelet production inhibition mediated by antiplatelet antibodies is a well-known mechanism causing low platelet counts in ITP \[[@B36]\]. However, there was no significant difference to be found between the NF-*κ*B-94ins/del ATTG polymorphism and antiplatelet GP IIb/IIIa and GP Ib/IX autoantibodies.

In addition, NF-*κ*B was crucial for the development and activation of Th cells and the disorder of NF-*κ*B could lead to impaired T cell function \[[@B37]\]. T-lymphocyte abnormalities are


controls in our research. Although the IL-1*β* (rs16944) polymorphism was reported to be associated with the risk of many autoimmune diseases \[[@B22]--[@B24]\], our data indicated that it did not influence susceptibility to ITP. In accordance with a previous study \[[@B41]\], our results showed that the IL-18 promoter -607 A/C polymorphism was almost equally distributed between ITP patients and the controls, which indicated that it may not be used as a stratification marker to predict the susceptibility to Chinese ITP.

Many studies have uncovered the performance of the CARD8 gene polymorphism rs2043211 in autoimmune disorders, RA, CD, and IBD \[[@B13], [@B14], [@B42], [@B43]\]. However, these findings were varied and even contradictory. For example, many studies on the association between the CARD8 (rs2043211) and CD susceptibility are quite inconsistent. A previous= 0.023), while no statistical difference was found for the percentage of Th22 cells (*p* = 0.173). (c) RORC expression was higher in the NLRP3 activation group of ITP patients (0.001845) compared with untreated ones (0.0002345; *p* = 0.012). (d) The percentage of Th17 cells for WW, WD, or DD were 1.94%, 3.23%, or 2.76% (*p* = 0.042) in the untreated group and 2.48%, 5.78%, or 3.51% after being stimulated (*p* = 0.405).](JIR2018-8170436.003){#fig3}

![(a, b) The frequency of late apoptosis was significantly increased after NLRP3 inflammasome activation or treatment with DEX.](JIR2018-8170436.004){#fig4}

######

Clinical characteristics of ITP patients and controls.

  Parameters                   ITP (*n* = 403)   Controls (*n* = 336)


Q:

How to avoid becoming frustrated while writing

Very often when I start writing something, mainly notes for my work (I'm a researcher) but other times personal thoughts, I feel that my writing speed can't keep up with my stream of consciousness.
Just to give an example, I was writing down on my notebook a question that I wanted to post on interpersonal.stackexchange but, as soon as I started with the main question, I ended up thinking about all the details that I want to add. I became frustrated at my inability to produce something and after a while I stopped writing (which pushed me to write this post).
In addition, I usually keep rereading what I've just written again and again and again, and keep changing it but without adding muchchallenge that we faced was her language barrier status. Preoperative counseling of patient was done with the help of translator that helped her in clear understanding about technique, possible discomforts and the need of being awake. Patient remained hemodynamically stable and pain free during the procedure. Besides, intraoperative neurological monitoring was done successfully which was helpful in doing gross total resection. The AT approach is routine at our health care setup. The technique has proven to be safe, very low complication rates including the conversion to GA. Similarly, it's been used patients having variable socioeconomic and educational backgrounds, as well as having different co-morbidities.6 The success of this in pregnancy is addition to its applicability. Though studies have shown some association with preoperative anxiety and postoperative pain in


of fly ash. This quantity is likely to touch 175 million tonne per annum by 2012. As per Environment Ministry guidelines, fly ash disposal problem will have to be eliminated through 100 per cent utilisation by 2013-14.

To make utilisation of fly ash products on mandatory basis as stipulated in Environment Ministry norms, incentivising their usage through duty exemption or remission is the only way, pointed out Power Ministry.

In India, about 200 billion bricks are produced annually. Less than the 25 per cent of them - the limit set by Finance Ministry to avail the duty concessions use fly ash.Red cells from a patient with a DPGM genetic variant who had erythrocytosis and no detectable enzyme activity contained a reduced amount of DPGM as determined by radial immunodiffusion. The abnormal DPGM differed from normal by immunoelectrophoresis and in stability as measured by the amount of crossreacting material in young versus old erythrocytes.


People v. Kraft (2000) 23 Cal.4th 978,
1053-1054), established that Angellano had a non-intercourse sexual relationship with
Jane Doe between June and December 2006, while she was a 17-year old high school
student and he was her coach on the school’s dance team. After she graduated from
college in 2011, Doe reported Angellano to police.
       In 2012, the People filed an information charging Angellano with five counts of
oral copulation of a person under 18 years of age (counts 1, 2, 4, 5 & 6), and five counts
of sexual penetration by foreign object of a person under 18 years of age (counts 3, 7, 8, 9
& 10). The charges were tried to a jury in September 2012. The prosecution presented
substantial evidence supporting the jury’s verdicts noted abovehe tells, and I think he needs some serious counseling. Knowing all this,
I told [the prosecutor] that I would be ok with a plea bargain. If he would only admit to
what he had done, only take that first step toward facing what had become of himself,
then that would be enough for me.”

                                               4
       “Now going through trial is different for everyone. . . . . Each human being is
unique. And you saw that right in this


you preyed upon them.

                                              5
            “It’s a violation of that trust position, Mr. Angellano, that is the gravamen, the
entire crime here. You were in a position of control, position of power, and you abused
it. . . .
            “. . . . And then you come into a courtroom and you perpetuate the fraud by lying
through your teeth. Oh, it happened withtotality, each part in its
context, the trial court’s comments show, in our view, that the court ordered Angellano to
register as a sex offender because he refused to recognize and acknowledge that he has a
deviant sexual predilection toward vulnerable, minor girls over whom he had the power
of a teacher and coach. Further, he not only refused to recognize his predilection, but, in
fact, lied about his conduct when he testified under oath.
       The trial court’s comments, when viewed in their entirety and context, show that
the court decided to order Angellano to register as a sex offender because the court found
that he posed the very type of danger against which the registration system is intended to
protect. (See generally Wright v. Superior Court (1997) 15 Cal.4th


   Angellano is correct that the trial court did not use the express words “as a result
of sexual compulsion or for purposes of sexual gratification” in ordering him to register

                                              7
as a sex offender based upon his six sex crime convictions. But we do not read Hofsheier
to require the use any talismanic words in ordering discretionary sex registration. What
Hofsheier requires is that a court makes certain findings, namely, that a defendant acted
as a result of sexual compulsion or for sexual gratificationPresident Barack Obama’s reshuffling of his national security team signals that the White House is likely to continue focusing heavily on its counterterrorism efforts in the Middle East and South Asia — while also preparing for pitched budget battles on Capitol Hill.

Just days before the killing of Osama bin Laden, Obama named CIA Director Leon Panetta as defense secretary and Gen. David Petraeus as CIA director.

Both appointments can be viewed as recognition of the prominent battlefield role of special operations and the CIA. The Navy SEALs, who conducted the mission in Pakistan, flew from Afghanistan under the CIA’s command — highlighting the steady growth of the CIA’s operational role in counterterrorism and U.S. covert actions in Pakistan since 2001.

The military and CIA rely increasingly on special operations forces.


what to do with thier lives when they are at a young age.

Why dont you try and sit down with Sarah and talk things out and see if you guys come up with a plan.

I know what you mean when you dont feel femme all the time. Ive had the same problem, what I do is not dress up or do anything for a while until I get the strong urge to dress up or feel dolly. I dont know what it is but when I put on an outfit I see myself as more prettier than ever. Try it and let us know how you feel.

For one each person has doubts. Not downplaying anything that is going on…it is just that is part and parcel of lifesome kind of sacrifice. Talk it over again instead and try to find another solution which provides more happiness for both of you.

Hi Ella,
I love your blog. Its so honest. I just read your latest post and it really struck a cord with me. I think we’ve had alot of similar, um, issues? Is issues the right word? I dont know. Have you been to the doctor about feeling low? I recently told my doctor about my own shit feelings (didn’t mention my gender issues, just that i was really down) and he was really good. He spoke to me for ages and then gave me some anti-depressents which really have helped alot. I was always against these sorts of drugs but if they help you stop feeling


offering value, why would you care at all?

-Most guys reek of insincerity and the girls immediately blow them off. This is especially the case when guys try to use "dominance" or "alphaness" as a CRUTCH to avoid being sincere.

-A sincere guy is focused making the OTHER person happy. This is so key because they are no longer self absorbed and therefore feeling SELF PITY.

-Most guys approach girls from a place of total self pity, desperate for the girl to be nice.

-To get out of neediness, consider how "charity" works. When you do charity, you get out of your own head and your own little world of problems, so you wind up feeling good. Most people think charity makes you feel good from "giving" but even moreso it's fromwouldn't ACTUALLY go out with them again.

-Rather, you'd go out with someone who has their own life and finances handled, and was sincere with you. Someone who would just joke around, and adds value by their presence.

-Sincerity is therefore based on the idea that JUST YOU BEING THERE makes the girl happy. A sincere person approaching is making them happy by default.

-From there simply lead and escalate and you're good to go.

-REMEMBER: dominance and physicality are NOT to be a CRUTCH to avoid being sincere. The worse sticking point in the community is guys just going from girl to girl trying to force compliance, instead of making them feel good.

-Come from a frame that you already have what you want, get out of your own self pity and


what they're given.

The disaffected professionals are probably the ones who bitch and gripe about
money compared to the old days. Uber is now trying to swallow up huge amounts
of market share by creating mammoth demand which will presumably lead to more
drivers (who haven't been weaned on better-paying services).

------
jellicle
If Uber drivers haven't figured out yet that the company's goals are to create
a huge workforce of barely-employed "contractors" who each earn just barely
enough to survive (probably have negative earnings in the long run, when car
depreciation is factored in - Uber knows that humans undervalue the car
depreciation and don't take it into account when figuring their profits and
losses), then I don't know what to tell them. They should figure that out.

~~~
username223
Yep. Uber apparently pays $1.50 per mile before its various surcharges [1],
while1, s: 12}?
1/13
Three letters picked without replacement from {w: 7, a: 3}. What is prob of sequence wwa?
7/40
What is prob of sequence wq when two letters picked without replacement from wwwqq?
3/10
What is prob of sequence cssp when four letters picked without replacement from {s: 3, p: 5, c: 2}?
1/84
What is prob of sequence iwi when three letters picked without replacement from iiwwiw?
3/20
Two letters picked without replacement from odjocc. What is prob of sequence dj?
1/30
What is prob of sequence pi when two letters picked without replacement from {i: 3, f: 2, m: 4, h: 2, p: 1, n: 2}?
3/182
Calculate prob of sequence thh when three letters picked without replacement from theahzj.
1/105
What is prob of sequence pktf when four letters picked without replacement from {t: 1, k: 1, p: 1,


I have been buying Holistapet CBD products for 4 months now and using them on my 9...read more→

Larry J.Dallas, TX

Rating: 5

No more NSAIDs, No more side effects

My vet has been prescribing my dog metacam for her inflammation and aspirin for pain but those drugs have been just giving her the worst side effects that I can't go on...read more→

Michelly CCharlotte, NC

Rating: 5

My dog Jamie had some crazy separation anxiety

Jamie was adopted early 2005 from the humane society. She has always been great with my 2 daughters growing up. When she was younger she got most all of the...read more→

Paula S.Charolette, NC

Rating: 5

Looks like he’s up and running again

We’ve been using these cbd dog treats for a few months now and they are really working for our dog Ziggy!are there between 12:39 PM and 3:35 PM?
176
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612
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9:15 PM
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624
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3:49 PM
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76
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11:43 PM
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543
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10:06 PM
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549
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14
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are there between 5:01 AM and 12:35 PM?
454
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42
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631
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360
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137
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10:32 AM
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432
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572
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8:57 PM
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141
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Q:

Joining 3 panda dataframes

Let me start out by saying this, I am unsure if this is the best way to do it, but I wrote some code to create a pandas' dataframe that contains the index values from my left dataframe and one from my right dataframe where specific spatial conditions match.  This is your basic spatial join, but with some additional attributes.  The index values are correct.
My issue is this, how can I join the left and right dataframe together with this 3rd dataframe?
I need to support the following:

If I want to keep all (from both df1 and df2), how do I do that?
By default I want to keep all left dataframe values, so my join dataframe has values like: [1, None] willrather than Washington to air out their grievances. What kind of signal would that send to others around the globe? It wouldn’t necessarily mean that the US is bad so much as it would signal that Mexico and Canada set the standard for excellence in governance (not an oxymoron, by the way; see Dr Foldvary’s piece for details).

Another fact the article takes care to point out is that authorities in Beijing have been quick to clamp down on internet usage. Check out this map of worldwide internet connected devices. It’s a little bit more honest than the maps showing China to be a giant “dark spot” of internet usage that I’ve seen displayed around the web.

Lastly, the article in question shows, once again, that the US has nothing


often attempt to create artificial stress because they know it makes you more likely to buy. That guy who knocks on your door offering to sell you the last frozen chicken in his truck at a discount? He's creating artificial pressure to get you to buy. Be cautious of Buy Here, Pay Here lots. If you decide to buy a car from a used car lot, be sure to read all of the papers before you sign. Don't sign contracts that allow the dealership to change the finance rate after you leave the lot. Work-at-home ads usually don't pay off. Be especially wary of ads that promise huge annual salaries; they often require expensive upfront fees with no guarantee. You risk losing your money and wasting a lotof time and energy.

Some of these probably seem obvious — others less so. It's all good advice, though. When I look at the list, I recognize several of these “commandments” that I've violated, particularly buying under stress. I've finally learned to just say “no” to anyone who wants me to make a decision now (especially if it's a transaction that I did not initiate), but it hasn't always been this way.

I'd add a few other “commandments” to this list. I've written before about seven essential skills to protect yourself from scammers, including:

Seek recommendations from people you trust. Referrals increase the odds of finding a quality professional. There's rarely a need to flip blindly through the yellow pages (or google) to find a mortgage broker or a roofing contractor.


with Auntient Pistoll. As it hath bene sundry times playd by the Right honorable the Lord Chamberlaine his seruants.

Title (Hamnet)

false

Title (Hamnet):

Chronicle historie of Henry the fift

bib_title

Chronicle historie of Henry the fift

Title (Hamnet)

false

Place of Creation or Publ. (Hamnet):

London :

bib_creation_place

London :

Place of Creation or Publ. (Hamnet)

false

Publisher (Hamnet):

Printed by Thomas Creede, for Tho. Millington, and Iohn Busby. And are to be sold at his house in Carter Lane, next the Powle head,

bib_creation_name

Printed by Thomas Creede, for Tho. Millington, and Iohn Busby. And are to be sold at his house in Carter Lane, next the Powle head,Sherlock Holmes narratives, each episode follows a mystery that needs solving and Miller and Liu prove to be quite a pair.Currently, the bonus features on the set haven’t been finalized, but we do know that a gag reel, deleted scenes, interviews with both the cast and crew, and other featurettes will be available. CBS Home Entertainment and Paramount Home Media Distribution are working together on the set and the two groups have also put together a deal with Target. Fans who go to the big box store to purchasewill also get a special bonus disc, although there is currently no word on what exactly the extra disc will entail.CBS sets frequently run on the more expensive side, but if you do go ahead and pre-order, you’ll be able


like the people in Spain.

But this plan never materialized, mainly because the Spanish crown lost control of the regular orders as soon as their friars set course to America.  Shielded by their apostolic privileges granted to convert natives into Catholicism, the missionaries only responded to their order local authorities, and never to that of the Spanish government or the secular bishops. The orders local authorities, in turn, only dealt with their own order and not with the Spanish crown.  Once a doctrine had been established, the protected their own economic interests, even against those of the King and thus, the doctrines became Indian towns that remains unaltered for the rest of the Spanish colony.

The doctrines were founded at the friars discretion, given that they were completelyThese Dolls by Rebecca Kemp Put a Fun Twist on the Classic Matryoshka

The dolls from Rebecca Kemp will make you fall in love with the classic matryoshkas dolls if you weren't a fan before. Her designs put a fun and colorful twist on the traditional Russian nesting doll.

Rebecca Kemp runs her Etsy shop Sketchinc and comes from North Wales in the United Kingdom. She loves "to play with color and geometric design," as clearly evidenced from her bright doll designs, according to her profile on Etsy. From ones that look like glow-in-the-dark ninjas to extreme clowns, these Rebecca Kemp designs reinvent the matryoshka in a highly modern and entertaining way.


of Saskatoon’s Dingwall Guitars knew McDougall for 40 years after meeting him as a 16-year-old.

“We all have the same story: we went in for an hour and came out eight hours later and had our minds blown,” Dingwall said in an interview.

“He was a mechanical genius, without a doubt. His ability to conceptualize machines that would do multiple operations, I think would be on a level with any of the top engineers at GM or Ford.”either.”

Get our Politics Newsletter. The headlines out of Washington never seem to slow. Subscribe to The D.C. Brief to make sense of what matters most. Please enter a valid email address. Sign Up Now Check the box if you do not wish to receive promotional offers via email from TIME. You can unsubscribe at any time. By signing up you are agreeing to our Terms of Use and Privacy Policy . This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Thank you! For your security, we've sent a confirmation email to the address you entered. Click the link to confirm your subscription and begin receiving our newsletters. If you don't get the confirmation within 10 minutes, please check your spam folder.

Sanders


Street because they are most afraid of a Clinton presidency.

“I have been speaking out against and working to rein in powerful forces for many years. I have the scars to prove that,” Clinton said. “They have spent a lot of money against me. I just want people to think about this: If Wall Street were so interested in supporting Democrats like the President and like me for their own reasons, whey are they spending $6 million trying to defeat me in this election?”

A spokesman for Sanders did not immediately respond to a request for comment.

Contact us at letters@time.com.Background {#Sec1}
==========

A significant task of system biology is to explore cellular function and organization by studying the PPI networks. Most of the functional processes within a cell are executed by protein complexes \[[@CR1]\]. Therefore, the identification of protein complexes is an important research problem in systems biology. In addition, understanding the biological functions is a fundamental task for different cellular systems and is beneficial for treating complex diseases. Due to the development of advanced high-throughput techniques, a large number of PPI networks have been generated \[[@CR2]\], which makes discovering protein complexes more convenient. However, how to accurately identify biological protein complexes has been an important research topic in the post-genomic era \[[@CR3]\]. The accurate identification of protein complexes in PPI networks is significant for understanding the principles of


            \setlength{\oddsidemargin}{-69pt}
                \begin{document}$JCS(b,a)=\frac {|\{d\}|}{|\{a,b,c,d,k,h,r,s\}|}= \frac {1}{8},JCS(a,d)=\frac {|\{b\}|}{|\{a,b,c,d,e,f,g,h,r\}|}= \frac {1}{9},JCS(b,c)=\frac {|\{d,k\}|}{|\{a,b,c,d,e,k,s\}|}= \frac {2}{7},JCS(c,d)=\frac {|\{b,e\}|}{|\{a,b,c,d,e,f,g,k\}|}= \frac {2}{8}$\end{document}$. According to Eq. ([3](#Equ3){ref-type=""}), the common proteins *a* and *c* support the edge *e*1 is $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
    is a small group of proteins that show high co-expression similarity and share high functional similarity, which is a key cellular role and the essential function for a protein complex \[[@CR31], [@CR35]\]. Unfortunately, due to the limitations of experimental methods, the functional information (gene ontology) of many proteins may be infeasible for the identification of protein complex cores \[[@CR51]\]. However, the core proteins in the same complex core show a high level of functional similarity and have relatively more common neighbors among themselves than among other proteins in the PPI networks \[[@CR15], [@CR36], [@CR51]\]. The biological functions of proteins are determined by their neighbors from the view of topological characteristics. This strategy is a good alternative in the absence of functional information. Thus, two proteins are assigned to


          \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$d_{weight}(p,Core(PC_{v}))\geqslant \frac {1}{2} weight_{avg}(Core(PC_{v}))$\end{document}$.

Here, *d*~*weight*~(*p, Core*(*PC*~*v*~)) is the total weight interactions of *p* with core proteins in *Core*(*PC*~*v*~), given by $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}measure according to recall and precision \[[@CR66]\] and it is used for evaluating the accuracy of the identified complexes. The F-measure could evaluate not only the accuracy of identified complexes matching reference complexes but also the accuracy of protein complexes matching identified complexes.

The identified complexes *P*={*p*~1~,*p*~2~,\...,*p*~*k*~} is generated by identified method, and *R*={*r*~1~,*r*~2~,\...,*r*~*l*~} is the reference complexes for any identified complex *p*~*i*~ and reference complex *r*~*j*~. First, we introduce the neighborhood affinity (*NA*(*p*~*i*~,*r*~*j*~)) between the identified protein complexes and reference complexes, which is presented as follows \[[@CR16], [@CR65], [@CR67]\]: $$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}


       \setlength{\oddsidemargin}{-69pt}
                \begin{document} $$ \begin{aligned} Precision = \frac{N_{mp}}{|P|}. \end{aligned}  $$ \end{document}$$

In general, a larger protein complex has the higher recall, while a smaller protein complex has higher precision. Therefore, the F-measure is defined as the harmonic mean of recall and precision, which The corresponding formulas are shown as follows \[[@CR69]\]: $$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
     4The effect of *ss*. Performance of EWCA with different structural similarity threshold *ss* is measured by all evaluation meterics, with respect to CYC2008 and NewMIPS standard complex sets. The x-axis denotes the value of structural similarity and the y-axis denotes evaluation metrics in BioGRID dataset. The F-measure is maximised at *ss*=0.4 on unweighted BioGRID dataset

As shown in Figs. [3](#Fig3){ref-type="fig"} and [4](#Fig4){ref-type="fig"}, with the increase of *ss*, the value of recall, MMR and CR decrease but the value of precision increases. It is shown almost similar trends in all cases. Furthermore, we study the behaves of EWCA in terms of F-measure. Notably, in DIP dataset, the value of F-measure increases gradually with the increase of *ss* until *ss* = 0.4. Here, when CYC2008 and NewMIPS reference complexes are used, the


EWCA is more effective and accurate. Furthermore, each method has unique characteristics, and selecting a clustering method suitable for your purpose is important. Additionally, EWCA can balance various assessment measures, which means that EWCA provides more insight for future biological studies.

We may be able to conceive these further research directions: The available PPI data are full of noise caused by high false-positive and false-negative rates \[[@CR75]\]. To overcome this issue, there are two ways to reconstruct a reliable PPI network by predicting new interactions among proteins \[[@CR76]\] and designing noise-robust methods \[[@CR77], [@CR78]\]. In fact, methods that integrate the two strategies could enhance the performance. In addition, EWCA could be applied to cluster other biological networks, such as metabolic networks and gene regulatory networks, and it can also-3*z. Suppose -m = -i, 0 = g*y + 3*m - 0*m - 57. Calculate the remainder when 29 is divided by y.
14
Let y(m) = -m**3 - 11*m**2 + 8*m - 2. Calculate the remainder when y(-12) is divided by 12.
10
Let u = -364 + 513. Calculate the remainder when u is divided by 38.
35
Suppose 6 = c - 0. Let u(i) = i**3 - 6*i**2 + 2*i + 2. What is the remainder when 40 is divided by u(c)?
12
What is the remainder when 22 is divided by ((-12)/8)/(1 - 20/16)?
4
Suppose 3*t = 6*t - 9. Suppose -t*b + 128 = -b. Let m = b - 45. What is the remainder wh


ID_Start properties have been updated to their current Unicode definitions.

Certain properties that are supposed to be Unicode internal-only were erroneously exposed by previous Perls. Use of these in regular expressions will now generate, if enabled, a deprecated warning message. The properties are: Other_Alphabetic, Other_Default_Ignorable_Code_Point, Other_Grapheme_Extend, Other_ID_Continue, Other_ID_Start, Other_Lowercase, Other_Math, and Other_Uppercase.

An installation can now fairly easily change which Unicode properties Perl understands. As mentioned above, certain properties are by default turned off. These include all the Unihan properties (which should be accessible via the CPAN module Unicode::Unihan) and any deprecated or Unicode internal-only property that Perl has never exposed.

The generated files in the lib/unicore/To directory are now more clearly marked as being stable, directly usable by applications. New hash entries in them give the format of the normalperl bug database at http://rt.perl.org/perlbug/ . There may also be information at http://www.perl.org/ , the Perl Home Page.

If you believe you have an unreported bug, please run the perlbug program included with your release. Be sure to trim your bug down to a tiny but sufficient test case. Your bug report, along with the output of perl -V, will be sent off to perlbug@perl.org to be analysed by the Perl porting team.

If the bug you are reporting has security implications, which make it inappropriate to send to a publicly archived mailing list, then please send it to perl5-security-report@perl.org. This points to a closed subscription unarchived mailing list, which includes all the core committers, who be able to help assess the impact of issues, figure out a resolution, and


a risk factor for glaucoma, and optic nerve head neovascularisation that is a sign of diabetic retinopathy. All nine patients who were scored as abnormal by optic nerve photography in our study had a Disc Damage Likelihood Scale scores of 3, indicating early onset of glaucoma. The majority of these patients were females aged between 20 and 64 years whereas two old age males were marked abnormal. Four patients were also obese and high BP was measured in two individuals, highlighting vulnerable status of young and middle-aged obese Indian population.

Smartphone-enabled tele-otology has been deemed suitable for both on-site and remote diagnoses of tympanic membrane and Otitis media (OM) previously.[@R39] Perforated tympanic membranes (59.2%) and/or effusions (47.6%) were most prevalent in patients labelled as abnormal by Ear, Nose and Throat surgeons. These= 0$. This is because, $t^m =\prod_{i=1}^n {z_i}^{q_i} \iff m=\sum q_i v^i ={\mathcal{B}^{-1}}q
 \iff q = m{\mathcal{B}}\iff q_i= {\langle}m,v_i {\rangle}$. The one is added to ensure that $V$ is anticanonical. Note that by definition of $\Delta$, ${\langle}m,v_i {\rangle}+ 1 \ge 0$. If $\lambda_{m_\sigma} \ne 0$ then $Y$ does not pass through the origin. It can be checked from this description using Bertini’s theorem that for generic values of the coefficients $\lambda_m, Y$ is a smooth submanifold of ${U_{\sigma'}}$ that intersects the coordinate planes $z_{i_1}=..=z_{i_j}=0$ transversely.\
$Y$ is ${G_{\sigma}}-$stable by (4.1.1). When $Y$ is smooth, all singularities of $V\cap {U_{\sigma}}$ are quotient singularities induced by action of ${G_{\sigma}}$ on $Y$. Since there are only finitely many $n$-dimensional cones, $V$ is nondegenerate and a suborbifold of $X$. $(Y,{G_{\sigma}},\pi_\sigma)$ is an uniformizing


since its fan is is obtained by coning over the faces of $\Delta$. In fact, ${\mathbb{P}}_{{\Delta^{\circ}}}$ = ${\mathbb{P}}_{\Delta}/ {\mathbb{Z}}_4^3$. This is also shown easily. First, observe that $w_1 = -w_2 - 2w_3 -2w_4 -2w_5 $. Secondly, if $\bar{M}$ is the sublattice of $M$ generated by $w_2,w_3,w_4,w_5$, then $M/\bar{M}$ = ${\mathbb{Z}}_4^3$.

The mirror Calabi-Yau family is also easy to write down. Let $z_i$ denote the homogeneous coordinate of ${\mathbb{P}}_{{\Delta^{\circ}}}$ correspoding to $w_i$. Then a generic Calabi-Yau hypersurface $V^{\circ}$ of ${\mathbb{P}}_{{\Delta^{\circ}}}$ has equation:

$\lambda_1 z_1^8 + \lambda_2 z_2^8 + \lambda_3 z_3^4 + \lambda_4 z_4^4
   + \lambda_5 z_5^4 + \lambda_6 z_1^4 z_2^4 + \lambda_0 z_1z_2z_3z_4z_5 = 0.$\
Note that $h^{1,1}_{orb}(V^{\circ}) = 86$ and $h^{2,1}_{orb}(V^{\circ}) = 2.$

Bibliography {#bibliography .unnumbered}
============

\[1\] V.Batyrev, *Dual polyhedra and Mirror symmetry for Calabi-Yau hypersurfaces in toric varieties*, AG/9310003\
\[2\]"Just Nice." "Goodbye adventure, goodbye cruise." "Just Nice." "Follow me." "Captain Stéphane welcomes you aboard." "We'll do the Promenade des Anglais in 1 minute and 17 seconds." "Our speed will be 210 km per hour." "I get the picture." "Didn't you see the sign?" "I don't like looking at signs." "Slow down a bit, please." "As you wish." "I'll apply the flaps." "Life's strange." "My family wasn't rich." "I never got any gifts for Easter." "You're my first Easter present." "It's a miracle." "I was thinking..." "What about?" "What if we drove in silence?" "Silence, the desert." "Fort Saganne." "Drop me off there." "I'm having dinner." "Are you coming?" "I'm not hungry." "Just a quick bite to eat." "We'll find a discrete little place." "Why 'discrete'?" "Quiet, I


the way... poor Marthe must be worried." "Call her." "She doesn't have a phone." "She has no phone?" "Not yet." "Let's go there!" "Where?" "Where does your aunt live?" "In Maubeu... eh Monaco." "Monaco... 3 am and it's far." "She can stay in the guest room." "But what about Marthe?" "No, no..." "I'll take her." "She's so tired." "I'll explain to her aunt." "Come with me." "Say something." "Monaco at this hour..." "She's crazy." "If only my aunt lived closer." "But this is insane." "I need to sleep." "Do you want a night gown?" "No, I always sleep naked." "I've been wanting to undress for hours." "Here's the bathroom." "There are clean towels in the cupboard." "When I think of Marthe worrying..." "Oh, my God." "Let him do"Is it here?" "Yes." "I often operate from home." "They force you to moonlight." "Congratulations." "You gave me a fright." "What happened?" "I'll explain." "Our friends are here." "I called them at the last moment." "Nice of them, isn't it?" "Very friendly." "Happy birthday." "What a joke!" "Always up to something." "I thought this would be funny." "And now the surprise!" "This is Julie, my stepdaughter." "Stéphane's daughter." "Have you been hiding her from us?" "She's here for her father's birthday." "Happy birthday, darling." "She's my daughter, my daughter, my very daughter." "Isn't she beautiful?" "You won't wear this all night, will you?" "Can you serve drinks?" "Of course, mommy." "She calls me mommy because I knew her when she was this high." "I hope you can explain


that touched me everywhere." "I didn't forget them." "Goodbye, Sophie!" "Goodbye, dear." "Everything has been said, hasn't it?" "Do you mind if I hug him?" "I insist even." "Is this really necessary?" "Goodbye." "Come, mommy." "Say goodbye to dad." "Goodbye, dad." "Goodbye, girl." "By the way, Catherine, little Catherine..." "Catherine?" "Your youngest daughter." "She looks even more like him." "You have another daughter?" "Maybe I shouldn't have..." "What are you saying?" "I don't know..." "That girl isn't mine." "Maybe not..." "Learn to count." "Terrible." "What?" "The role you make me play." "What role?" "The role of home wrecker, ruining a family with two children." "What are you going to do?" "I'll leave you to your family." "Sophie?" "Don't touch me!" "No, Sophie!" "Listen..." "Listen to me, Sophie." "GiveQ:

How can I SUM alphanumeric values in Google Sheets?

It's not the best system but I've been using ImportXML to pull in YouTube view counts for my videos so I can keep track. I knew at some point YouTube would make a front end change that would break this. So now recently instead of just the number inside of the DIV I am referencing they are always showing the word "views". So here's what I'm using now
=IMPORTXML("https://www.youtube.com/watch?v=qXnr03IIPTI","//div[@class='watch-view-count']")

This will output "300,000 views" (or whatever the current view count is)
Before they added the word "views" in this DIV I was able to add up this column. So I added another column to strip out the text.
(where G7 is the cell containing the above value)
=SUBSTITUTE(G7, "views", "")

I thought for sure I would


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The complete set of contributors may be found at http://polymer.github.io/CONTRIBUTORS.txt
Code distributed by Google as part of the polymer project is also
subject to an additional IP rights grant found at http://polymer.github.io/PATENTS.txt
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<link rel="import" href="../../../shadycss/apply-shim.html">
<link rel="import" href="../mixins/element-mixin.html">
<link rel="import" href="../mixins/gesture-event-listeners.html">
<link rel="import" href="../mixins/dir-mixin.html">
<link rel="import" href="../utils/mixin.html">
<link rel="import" href="../utils/import-href.html">
<link rel="import" href="../utils/render-status.html">
<link rel="import" href="../utils/unresolved.html">
<link rel="import" href="polymer.dom.html">

<script>
(function() {

  'use strict';

  let styleInterface = window.ShadyCSS;

  /**
   * Element class mixin that provides Polymer's "legacy" API intended to be
   * backward-compatible to the greatest extent possible with the API
   * found on the Polymer 1.x `Polymer.Base` prototype applied toProvides an override implementation of `attributeChangedCallback`
       * which adds the Polymer legacy API's `attributeChanged` method.
       * @param {string} name Name of attribute.
       * @param {?string} old Old value of attribute.
       * @param {?string} value Current value of attribute.
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       * work. The implementation should ensure the work is performed
       * only once for the class.
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       *  _ensureAttributes() {}

      /**
       * Adds element event listeners. Called when the element
       * is being readied via `ready`. Users should override to
       * add any required element event listeners.
       * In performance critical elements, the work done here should be kept
       * to a minimum since it is done before the element is rendered. In
       * these elements, consider adding listeners asynchronously so as not to
       * block render.
       * @protected


    * to children that are insertion points.
       * @param {string} selector Selector to run.
       * @return {!Array<!Node>} List of effective child nodes that match selector.
       */
      queryAllEffectiveChildren(selector) {
        return this.queryDistributedElements(selector);
      }

      /**
       * Returns a list of nodes distributed to this element's `<slot>`.
       *
       * If this element contains more than one `<slot>` in its local DOM,
       * an optionalInclude="$(SharedContentDir)\media\splash-sdk.png">
      <Link>Assets\splash-sdk.png</Link>
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isolated phagocytes or phagocyte-like cell lines such as HL-60 are used[@b8][@b9][@b10][@b11]. However, this is by no means representative to the real live situation in whole blood. For instance, the isolation of neutrophils leads to priming, which affects the ability of the neutrophils to form reactive oxygen species and changes their responses to cytokines[@b12]. In addition, serum has altered levels of coagulation proteins compared to plasma in whole blood. An example is plasminogen[@b13], which can bind to the bacterial surface of *S. pneumoniae* and is involved in bacterial virulence[@b14][@b15]. Another example is fibrinogen, shown to bind to *Streptococcus pyogenes* M protein, which decreases C3b deposition and opsonophagocytosis[@b16][@b17].

To circumvent these limitations in order to study complement-mediated opsonophagocytosis of bacteria, we explored the possibility to use whole blood directly after venousbacterial surface by phagocytes contributes to killing. The contribution of the CR3 in opsonophagocytosis is *S. pneumoniae* by neutrophils and macrophages is widely investigating[@b49][@b50][@b51], and our results are consistent with these studies.

In addition, treatment of blood with cytochalysin D, an inhibitor for actin polymerization, also decreased killing of *S. pneumoniae* ([Fig. 3A](#f3){ref-type="fig"}), indicating that killing was dependent on phagocytosis.

Recently, Corriden *et al*. showed that tamoxifen augmented neutrophil-mediated killing of *S. aureus, E. coli* and *Pseudomonas aeruginosa* through enhancing several pro-inflammatory pathways in human neutrophils, including chemotaxis, phagocytosis and neutrophil extracellular trap (NET) formation[@b52]. Here, we show that adding 10 μM 4-hydroxytamoxifen significantly augmented killing of *S. pneumoniae* in whole blood ([Fig. 3B](#f3){ref-type="fig"}).

Killing of *S. pneumoniae*, but also other pathogens, is affected by the presence of opsonizing antibodies and the


only a third of Britain’s billionaires were actually born British, according to the Sunday Times Rich List.

Indian-born brothers Srichand and Gopichand Hinduja top the UK rich list, with a combined wealth of £11.9billion from their global conglomerate.

They are followed by international tycoons and oligarchs who made their fortunes in aluminium, oil and coal, including Chelsea owner Roman Abramovich.

Arsenal shareholder Alisher Usmanov and Queens Park Rangers stakeholder and steel magnate Lakshmi Mittal also feature.

The only British-born billionaire in the top ten is the Duke of Westminster, who owns swathes of central London and takes tenth place in the list with his £8.5billion fortune.

Britain’s reputation as a financial capital and its relatively low tax regime have been credited for attracting ‘non-dom’ residents, keen to invest in property in London andan email from the apartment complex about “an increase in community noise complaints.”

Oh well. I tried.

All right. I know that it’s entirely possible that they complained before I posted the letter on their door. Maybe they have made peace and did not tell us. Or maybe they hate us despite my attempt to make peace and are plotting for our destruction. Either way, we’ll keep it down. I don’t want a whole Neighbors thing to go down.


Post navigation

WE ARE IN HIS HANDS

The Lord does personally speak his Faith over you and it comes down and hits you. God’s own Heavenly Faith which is most powerful in its source, [unlimited and unfathomed without limits or bounds] moves within the heart of the one whom it is sent than it grows, even intensifies, strengthening of the soul.

God himself is the source and He did create everything we see, like the Heavens vast and the Earth below and all creatures. He spoke forth from his unlimited Faith and there appeared elements that had never existed, then from this storehouse of elements, he did make all things. With his own hands He did stretch out the universe like a cloth and made the heavenly bodies within.

Minute and insignificantQ:

Is there a way to have some shared data between different objects?

I'm working on a form class and my current code looks as follows:
$Form->addElement(new FormElementText($name, $value));

e.g.
$Form->addElement(new FormElementText('user_name', $values['user_name']));
$Form->addElement(new FormElementText('user_nick', $values['user_nick']));

The string for $name will always be the same as the index string for $values.
Is there a way to store $values in a central place for all form elements, so that I could pass the $name argument alone? I suspect no (besides global $values), but here's hoping...
Edit: Someone was suggesting the use of static properties, but deleted their answer fairly quickly. This seemed to be a workable solution and after trying it out, it does the trick.
FormElementText::$values = $values;
$Form->addElement(new FormElementText('user_nick');

and inside FormElementText
$value = self::$values[$this->name];

A:

Statics
First and foremost, let's dismiss the need for statics. If you code a static into your


two narrow beams. The scan is oscillatory in nature, i.e. in one angular sense through the sector of space and then immediately in the other angular sense through the same sector of space. One beam is devoted to such a scanning action in the azimuth plane and the other in the elevation plane.
Equipment on an aircraft on landing approach can determine its angular position with respect to runway center by determining time between successive beam crossovers. Since the scan is reciprocating, i.e. back and forth or up and down for azimuth and elevation situation respectively, the closer the bearing of the aircraft is to the angular starting point of each cycle of first and second scan senses, the greater will be the time delay between first and second

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<a href="#content" title="<?php esc_attr_e( 'Skip to content', 'twentyten' ); ?>"><?php _e( 'Skip to content', 'twentyten' ); ?>

                <?php /* Our navigation menu.  If one isn't filled out, wp_nav_menu falls back to wp_page_menu.  The menu assiged


More than 400000 Ukrainian women ended up to be the victims of sex industry in Europe during 2000-2014. We have to warn them and not to apply on ghost job offers.

When enslaved by sex industry, the woman becomes a ghost she has no legal rights, no passport, no future, and in some cases frauds take away their lives by setting them on drugs or just killing them . Just like ghosts they have pale and painful existence within the walls of nightclubs.about how to stay looking fresh for years.

The top tips? Across the board, every woman we interviewed preached the values of daily sunscreen (SPF 30), establishing a nightly cleansing routine, and above all, drinking TONS of water. While this is nothing new, to hear each platitude repeated drove it a little further home, and I've found myself religiously guzzling more water ever since. Bottoms up!


attempt to re-allege the
establishment of secondary meaning.
      “Collateral estoppel applies when, in the initial litigation, (1) the issue at
stake in the pending litigation is the same, (2) the issue was actually litigated,
and (3) the determination of the issue in the initial litigation was a necessary
part of the judgment.” Harvey Specialty & Supply, Inc. v. Anson Flowline Equip.
Inc., 434 F.3d 320, 323 (5th Cir. 2005). “Complete identity of parties in the two
suits is not required. A preclusion defense, subject to certain conditions, may be
invoked by a non-party against a party to the prior suit, and, in limited
instances, against a non-party by a party to the prior suit.” Terrell v. DeConna,
877 F.2d 1267, 1270 (5th Cir. 1989). This is a case of defensive non-mutual
collateral estoppel.developments in its establishment of secondary meaning post-2003.
In fact, Robin Singh presents similar facts and evidence concerning the same
time-frame as the facts and evidence presented to this court in Test Masters II.
Therefore, Robin Singh does not allege any factual change since the ruling in
Test Masters II and again presents the same types of factual allegations that
deal primarily with Robin Singh’s recent business success. As we noted in Test
Masters II, Robin Singh’s business “success is not dispositive of the question of
secondary meaning.” 428 F.3d at 576. For the same reasons as in Test Masters
II, wherein we found no significant factual change during that same time-period
since Test Masters I, we also conclude here that no significant intervening
factual change has occurred during that same time period based on similar
factual allegations. See


legalize discrimination against them, but even these efforts only succeeded in two states — and both of those bills have been blocked by federal courts.

Unable to win in federal court or the court of public opinion, the religious right adopted a new tactic. With the assistance of the Texas attorney general, whose office is stocked with former attorneys from the same legal organizations that fought to prevent same-sex couples from legally marrying, they are using a courthouse in Wichita Falls, Texas as the launching pad for a sustained attack on the rights of transgender people across the country. The majority of the nation’s federal appeals courts have held that discrimination against transgender people is a form of sex discrimination under our country’s civil rights statutes. But by filing {EOL}  {
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this scoring mess?

A:

The official cribbage rules make this incredibly clear:

Rule 1.6 - Definitions
  ...
  go: Called by a player who cannot play a card without exceeding the cumulative count of 31; the opponent scores one point, or two if reaching exactly 31.

In this, calling a 31 is just a special case of a go.

the end, the communication was great & they cared for my items as if they were their own. Can’t ask for more from a moving company!

— Vyacheslav A. of Melbourne, FL

Why Allied Van Lines?

Allied Van Lines has the largest mover network in the world combined with over 85 years of experience. Whether you are relocating long distance or locally, our global network ensures that no matter where you're going, Allied can get you home. As a full-service mover, we handle everything from packing, loading, transporting, and unpacking your belongings.

Our mission is to provide affordable moving services backed by a name you can trust. We are a company built on a history of service, and it is our pleasure to assist you as you plan and prepare for your


INTRODUCTION {#h0.0}
============

Influenza A viruses are the causative agents of annual epidemics of respiratory disease and occasionally generate pandemics with variable consequences for human health and the global economy ([@B1]). The 1918 pandemic caused some 50 million deaths ([@B2]), while the last pandemic, in 2009, was much milder and a normal yearly epidemic causes up to 500,000 deaths worldwide (<http://www.who.int/mediacentre/factsheets/fs211/en/>).

The genome of influenza A viruses is a set of eight single-stranded, negative-polarity RNAs that are assembled in ribonucleoprotein complexes (RNPs) and incorporated into enveloped particles ([@B3]). Upon entry into the infected cell, viral RNPs are imported into the nucleus, where viral transcription and replication take place. The first step in virus gene expression is transcription from the parental RNPs, and translation of these early viral mRNAs is essential forbecause it is not toxic to the cells and leads to partial viral protein synthesis inhibition (see [Fig. 4](#fig4){ref-type="fig"}). Duplicate biological replicates were subjected to Illumina sequencing after removal of rRNA. Analysis of the virus RNA sequences obtained verified that treatment with MK does not alter the accumulation of positive-polarity or negative-polarity viral RNAs during infection ([Fig. 3C](#fig3){ref-type="fig"} and [D](#figS3){ref-type="supplementary-material"}) and also indicated that the virus splicing process is unaltered by MK, since the M1/M2 and NS1/NEP mRNA ratios are indistinguishable under both experimental conditions (see [Fig. S3](#figS3){ref-type="supplementary-material"} in the supplemental material). To further verify whether viral transcription is altered by MK treatment, the accumulation of primary transcripts was determined by RT-qPCR of total cell RNA isolated from cells infected in the presence of cycloheximide, treated with MK or left untreated.


induces PERK phosphorylation and counteracts the influenza virus-induced block of the PERK pathway. {#s1.4}
------------------------------------------------------------------------------------------------------

The first step in the induction of the PERK-dependent UPR is the dimerization and autophosphorylation of PERK ([Fig. 6A](#fig6){ref-type="fig"}), and the transcriptomic analysis shown above suggests that MK treatment stimulates PERK phosphorylation. To directly evaluate this possibility, we measured the amounts of P-PERK and total PERK in mock-infected and influenza virus-infected A549 cell cultures treated with various MK concentrations. As a control for PERK phosphorylation, the cultures were treated with thapsigargin, a well-known UPR stimulator ([@B60]), and a clear increase in the levels of P-PERK was observed in both mock- and virus-infected cells ([Fig. 6B](#fig6){ref-type="fig"}, C+). Treatment of normal cells with MK progressively induced PERK phosphorylation ([Fig. 6B](#fig6){ref-type="fig"}, MOCK), while virus infection reduced the P-PERK levels ([Fig. 6B](#fig6){ref-type="fig"}, compareFLU with MOCK, untreated). Treatment of virus-infected cells with MK led to the restoration of P-PERK levels to those found in normal cells ([Fig. 6B](#fig6){ref-type="fig"}, compare lanes MOCK 0 and FLU 40). In agreement with the results shown in [Fig. 2C](#fig2){ref-type="fig"}, the NP accumulation was strongly reduced upon treatment with MK at 40 µM and, interestingly, it was also reduced upon treatment with thapsigargin ([Fig. 6](#fig6){ref-type="fig"}, NP, C+). The quantitation of several experiments similar to that presented in [Fig. 6B](#fig6){ref-type="fig"} is presented in [Fig. 6C](#fig6){ref-type="fig"} and indicates an opposite and statistically significant variation of PERK phosphorylation by virus infection and by MK treatment.

![MK treatment reverses influenza virus-induced PERK dephosphorylation. (A) Scheme of pathways activated by accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum. The pathways activated by ATF6, PERK,


replication ([@B72]), probably because of a defect in caspase-3 activity and the subsequent retention of progeny RNPs in the nucleus (reviewed in reference [@B68]). Similarly, activation of the Raf/MEK/ERK pathway appears to be important for late events in the virus replication cycle, since its inhibition also leads to the accumulation of progeny RNPs in the nucleus. In this case, an ERK-dependent phosphorylation event in the viral NP or cellular factors seems to fire RNP export as a result of the late accumulation of viral hemagglutinin at the cell surface ([@B29], [@B73]). On the other hand, activation of the PI3K/Akt pathway by virus infection is bimodal. While an early burst of PI3K activation is induced by virus binding and is important for virus entry ([@B74]), late stimulation was also(reviewed in reference [@B80]). When used at higher doses in influenza virus-infected human cells, MK preferentially reduced viral protein synthesis and accumulation ([Fig. 2](#fig2){ref-type="fig"} and [4](#fig4){ref-type="fig"}) without altering virus transcription or splicing ([Fig. 3](#fig3){ref-type="fig"}; see [Fig. S3](#figS3){ref-type="supplementary-material"} in the supplemental material). These findings are consistent with the stimulation of PERK phosphorylation observed upon MK treatment of mock-infected cells and the reversal of the virus-induced downregulation of PERK phosphorylation ([Fig. 6B](#fig6){ref-type="fig"} and [C](#fig6){ref-type="fig"}). Consistently, transcription of GADD34/PPP1R15α was not enhanced in virus-infected cells by treatment with MK (see [Table S3](#tabS3){ref-type="supplementary-material"} in the supplemental material).

The mechanism by which MK elicits activation of the PERK-mediated UPR but not the ATF6- and IRE1-dependent arms is not clear at this time. Treatment with MK does not downregulate the GADD34/PPP1R15α regulatory cofactor, but it is able to counteract virus-induced GADD34/PPP1R15α


with 3% bovine serum albumin for 1 h and then incubated with the primary antibodies for 1 h at room temperature. For Western blotting of phosphorylated proteins, the membranes were saturated with 5% milk for 1 h and then incubated with the primary antibodies overnight at 4°C. The filters were washed with PBS containing 0.25% Tween 20 (Tris-buffered saline containing 0.25% Tween 20 for phosphorylated proteins) and incubated with the appropriate secondary antibody conjugated to horseradish peroxidase. After further washing as described above, the filters were developed by enhanced chemiluminescence. The procedures for protein labeling *in vivo* have been previously described ([@B91]). Cultures were washed, incubated for 1 h in a DMEM medium lacking methionine-cysteine, and labeled with \[^35^S\]methionine-cysteine to a final concentration of 50 µCi/ml. After incubation for 1 h, total extracts werethe radial current estimation are limited by the integration time. The resolution to which the current can be determined from the spectral rays of the radar signal even in the absence of noise is in principle limited by the frequency resolution ($\Delta U_r = \lambda/2T$). The actual accuracy can be to some extent improved by the centroïd method which allows choosing intermediate frequencies between the spectral rays [@barrick1980]. The reliability of the estimation in presence of noise (that is, the ability to detect a ’true’ Bragg line) depends primarily on the SNR [@forget_RS15], which can be shown proportional to the integration time. Hence using short integration times deteriorates the quality of the estimation in a twofold aspect. As we will show, the use of AR modeling makes it


series. In this section, we present an analysis of such time series arising from the Cap Bénat site in the light of the AR-MEM. The data set used as a benchmark for the derivation of radial surface current maps was recorded on February 4, 2019, 14:01 UTC.

Figure \[fig:carto\_comparaisons\] shows four radial surface currents maps processed from the same dataset with either the FFT method or AR-MEM. The same QC (eq. \[QC\]) was used and different sample durations were tested (6 and 1 min, respectively). As seen, both methods provide consistent maps but AR-MEM allows for a significant improvement of spatial coverage and range of available radial currents. This amelioration is drastic for short samples where the FFT method gives very sparse results.

![Maps of radial surface current $U_r$ (colorscale; m.s$^{-1}$) acquiredradar coverage were chosen. Continuous sequences were acquired over 30 hours and split into contiguous non-overlapping sub-sequences of either 4096 (1065 seconds or about 18 minutes) or 1024 (266 seconds or 4.5 minutes) time steps corresponding to “long” and “short” integration time, respectively. These sub-sequences were processed with the AR-MEM and FFT method and the corresponding time series of radial current were produced. A comparison was also made with a recent parametric method for surface current estimation based on a Maximum Likelihood Estimation (MLE) [@guerin2018]; this last method has been proven useful for short integration time.

An example of the radial current time series obtained with different methods and different integration times is shown in Figure \[fig:timeseries\] for a radar cell located at a range 35 km and at a


line) while it pursues its fall off over one extra order of magnitude when estimated with the AR-MEM. The $-5/3$ slope is marked in thick dashed line and is seen to drive the dynamics of the PSD over at least two decades. Such power law decay has already be reported in the literature [@thorpe2007], $$P(\omega) \propto \omega^\alpha$$ where the exponent $\alpha$ depends on the flow regime. The value $\alpha=-5/3$ is typical of Kolmogorov theory of turbulence and is recovered when inertial forces dominates over viscous.

![Experimental spectrum of the radial surface current $U_r$ at a given radar cell. $U_r$ estimated with: [ **——**]{} MEM, short integration time ($N=1024$ time steps); [ **——**]{} FFT, long integration time ($N=4096$ time steps). Data have been acquired on Feb. 6th to 10th, 2019, with the Cap BénatBogle, and DD Crombie. . , 62(6):673–680, 1974.

Robert Stewart and Joseph Joy. . , 21(12):1039–1049, 1974.

Donald E Barrick, MW Evans, and BL Weber. . , 198(4313):138–144, 1977.

K-W Gurgel, G Antonischki, H-H Essen, and T Schlick. . , 37(3-4):219–234, 1999.

Anna Dzvonkovskaya, Leif Petersen, Thomas Helzel, and Matthias Kniephoff. . , 5(1):29, December 2018.

Charles-Antoine Gu[é]{}rin, St[é]{}phan T Grilli, Patrick Moran, Annette R Grilli, and Tania L Insua. . , 68(4-5):423–438, 2018.

K.E. [Laws]{}, J.F. [Vesecky]{}, M.N. [Lovellette]{}, and J.D. [Paduan]{}. . In [*Oceans MTS/IEEE*]{}, September 2016.

M Berta, L Bellomo, M G Magaldi, A Griffa, A Molcard, J Marmain, M Borghini, and V Taillandier. . , 128:15–29, 2014.

Charles-Antoine Gu[é]{}rin and Stephan T Grilli. . , 121:105–116, 2018.

Rafaat H Khan. . , 16(2):181–188, 1991.

RJ Martin and MJ Kearney. . , 22(1):151–155, 1997.

A Middleditch and LR Wyatt. . , 31(4):797–803, 2006.

Wei Wang and Eric W Gill. . , 32(8):1515–1524, August 2015.

W. [Wang]{}, E. W. [Gill]{}, and W. [Huang]{}. . , 42(3):556–565,


and A. Molcard. The multistatic [HF]{} radar network in [T]{}oulon. In [*IEEE Radar 2019 Conference*]{}. IEEE, 2019.

A. Farina. . Peregrinus, 1987.

Steve A. Thorpe. . Cambridge University Press, 2007.

[^1]: B. Domps and J. Marmain are with the Radar & Scientific Applications Department, Degreane Horizon, Cuers, France (e-mail: {baptiste.domps,julien.marmain}@degreane-horizon.fr). D. Dumas and C.-A. Guérin are with Univ. Toulon, Aix-Marseille Univ., CNRS/INSU, IRD, MIO UM 110, Mediterranean Institute of Oceanography, La Garde, France (e-mail: {dylan.dumas,guerin}@univ-tln.fr).

[^2]: This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible.
Defiant as ever, Brisbane coach Wayne Bennett says controversial signing Matthew Lodge deserves his place in the NRL and has done everything required to be given another chance in the code.

Lodge will start at prop for the Broncos when they open the NRL season on Thursday night against the Dragons. But the football has been barely mentioned as Lodge continues to deal with the ramifications of his wild night in New York in 2015.

Last chance: Matt Lodge has impressed in training with Brisbane. Credit:AAP

A drunk Lodge terrorised a family, narrowly avoided jail and was ordered to pay $1.6m in compensation by a US civil court. Fairfax Media revealed not a cent of that had been paid, while frightening footage of the attack has surfaced over the past week.

Bennett


Almost all local newspapers put Sunday’s march against the controversial extradition bill on their front pages. Many focused on the apology issued by Chief Executive Carrie Lam. A few splashed the organiser turnout estimate of two million, though the police said 338,000 marched along the designated route at the rally’s peak. HKFP rounds up the frontpages from the local press.

Apple Daily

“Write our own history – two million and one. Hong Kong people: Carrie Lam step down”

The pro-democracy Apple Daily put one of the protesters’ main demands on the front page with a photo showing the heaving crowd. The “one” refers to a protester who fell to his death on Saturday whilst protesting against the extradition bill.

Ming Pao

“Protesters urge Carrie Lam to step down, Lam issues statement to apologise;The Very Model of Modern Gilbert and Sullivan

Share this:

CHICAGO: Beach balls and banjoleles weren’taround when Gilbert and Sullivan penned their operettas in the late 1800s, but that doesn’t stop The Hypocrites from using them in their adventurous takes on the duo’s work. Throw in some kiddie pools, maybe a mouth harp or two, and stage it promenade-style with the actors surrounding the audience and you get an idea of what it’s like to spend time with Gilbert and Sullivan through the Hypocrites’ eyes.

When the Chicago-based company started incorporating musicals into their repertoire, founding artistic director Sean Graney struggled to find shows in the public domain. His aesthetic relies on an improv-driven collaboration in the rehearsal room in order to create an original adaptation—and artists can’t change a word


back to your daughter's picture any time you want.

JORDAN: Okay.

THERAPIST: Ready?

JORDAN: Yes, ready.

THERAPIST: Okay, choose one of the images that bother you, but don't pick the worst one to start. Just one.

_It was important to start with something that had a good chance of being manageable. The idea here was to build on success. Better to take many successful small steps than try to hurry the process with a few big steps that could result in failure._

JORDAN: I'll start with the first image I saw on television. When I first turned on the TV I saw the first tower on fire.

_It is also good to give the client the choice of image when possible._

THERAPIST: Put that image on your screen. Can you make it a still image?

JORDAN: Yes,last task. I want you to imagine driving to work tomorrow, nearing downtown, seeing the skyscrapers. How do you feel?

JORDAN: I'm not scared, but I still feel sad. I also feel very grateful as I look up at the skyline that our city is whole. We were lucky.

_Further cognitive integration._

THERAPIST: It's possible that the intrusive images could appear again. What would you do?

_Because his problem had permeated his daily life, it was important to anticipate that it could persist. Planning for future intrusions would make it possible for him to be able to continue to feel in control._

JORDAN: Well, I have a lot of choices to try. First, I'd probably rather see my daughter's face. But it might be a good idea to change the image, turn the


Pablo Sandoval

In this April 11, 2017, file photo, Boston's Pablo Sandoval plays third base during the second inning of a baseball game against Baltimore at Fenway Park in Boston. On Friday, July 14, 2017, the Red Sox announced that Sandoval had been designated for assignment after being activated from the 10-day disabled list. (AP Photo/Charles Krupa, File)

The Boston Red Sox handed Pablo Sandoval a fat five-year, $95 million contract after 2014. Since then he's only played 161 games for Boston since 2015, and hit for a .237 average, making him one of the worst free agent signings of all time. However, there have been other players who were far less productive after signing huge contracts. What do you think?

PERSPECTIVES

When a team gives a player $19 million, fans usuallycouldn't do much on the field. But with other albatross contracts like Josh Hamilton still affecting the Los Angeles Angels, you can't say Sandoval's contract is the worst. The Angels are still paying the remaining $63 million in dead money when they unloaded Hamilton to the Texans after heading back rehab.

There are other contracts that are worse than Sandoval's.

MORE: How Pablo Sandoval's awful contract compares to MLB's worst

Not even close. Rick porcello is worst. Even worse than Sandoval. — Mikepaaaatts (@FrostBeast666) July 1, 2017

The Tylt is focused on debates and conversations around news, current events and pop culture. We provide our community with the opportunity to share their opinions and vote on topics that matter most to them. We actively engage the community and present meaningful data on


I just won.

So get your metal on and be sure to come join all the Groovy Gurls for this challenge! You can find the challenge HERE. And if you want to purchase any (or all!) of the images (and why wouldn't you?) go HERE.

Thursday, September 23, 2010

We're having a really fun challenge over on the StampInsanity blog this week - embossing! It can be wet or dry embossing. I don't wet emboss much anymore so I had fun digging into my embossing powder for this card. I also had a little fun with some eyelets and ribbon. I thought it would work well to lace up some ribbon on the card to reflect the lacing on her bodice. I had fun doing it and I hope you like

The Hottest Thing in Startups? Babies (A founder-father's homebirth story) - dariusmonsef
http://hellobubs.com/post/23494489962/homebirth-midwives-becoming-the-ultimate-dudela

======
tcabeen
LOVE this. Homebirth is so scary until you learn more about it. Then the
opposite becomes true.


York and Pennsylvania have such a rule. It turns out that Virginia and California do, too. But because of some likely combination of prosecutorial skill and luck, Manafort still faces prosecutions in those states, plus perhaps Illinois and others.

Let’s first focus on just the crimes for which Manafort has already been tried. This week, he was convicted of five counts of tax fraud, two counts of bank fraud, and one count of failing to report a foreign bank account. In New York and Virginia, where he held residences, double jeopardy laws prevent him from being charged for the exact same crimes. But state tax fraud is a distinct crime, one that he almost certainly also committed. When one fraudulently hides income from the federal government, one has tohide that same income fraudulently in state tax returns in order to avoid incriminating inconsistencies.

Virginia’s double jeopardy statute bars secondary state prosecutions for committing “the same act” in “violation of both a state and a federal statute.” Filing a state tax return, though, is a separate act from filing a federal return. So filing an unlawful state tax return in Virginia would be separate, prosecutable act from Manafort’s federal filing, one that cannot be pardoned by Trump. The Virginia tax law further covers fraud, and a Virginia return that replicated his federal one would contain the same fraudulent material as his federal return.

Further devastating for Manafort’s pardon hopes, according to Virginia rules of evidence, past convictions can be admissible: “Such evidence is admissible if it tends to prove


principle of state sovereignty to prosecute would apply to any crimes Trump himself may have committed. If Trump is foolish enough to try to pardon himself, there will be no holding back the state prosecutor.

Read more from Slate:

The Trump Organization’s CFO Got Immunity From Prosecutors, but Let’s Hold Our Horses on Calling It a Game-Changing Flip

Trump Isn’t Mad at Jeff Sessions. He Actually Agrees With Him and Has Some Tips!

John McCain Ends Treatment of His Brain Cancer, Is Said to Be Near Death

We Don’t Need an Investigation to Know Trump Betrayed His Country. All the Evidence Is Right Here.

Correction, Aug. 24, 2018: This article originally misstated that Manafort had his bail revoked for jury tampering. It was alleged witness tampering.be an useful way to convert your clients into those who are happy to keep returning for more. Exercising control is of the essence as clients will probably be repelled by a technique that is perceived as being too pushy.

One excellent way to gain an understanding of customer behavior patterns is to have a look at your very own sales. Seeing a decrease in the volume of sales can be a predictor of consumers desiring higher quality or more innovative dogs and pups. If there is a slump in your sales, you must rapidly aim to new innovation, patterns, and innovative procedures. Taking time to participate in trade shows related to the pet dogs and puppies and young puppies and young puppies you promote can be a good


conjecture is mathematics says that every even number greater than can be written as the sum of two primes. This is called the Goldbach Conjecture and recently much work has been done in this direction. But that is a different story, one which we shall not discuss here and is left for a future post.

This now brings us to the most important application of prime numbers: cryptography. We have become so used to computers and the internet that not many of us know how much non-trivial mathematics hides behind simple stuff that we take for granted. Almost everyone of us have used our Debit or Credit cards to make a purchase online. How do you know that such a transaction is safe? The reason behind this is somethingproblem of determining whether a given number is prime or not. This is normally a very difficult thing to do. This problem has been around for centuries and many great mathematicians like Gauss, Fermat, etc have worked on this. Before 2003, the methods that were used to find whether a number was prime or not either were very slow and cumbersome or were randomised in the sense that it gave an answer with some amount of chance or probability associated with it. But all this changed when in 2003, three Indian computer scientists solved this long standing problem of finding a test to determine whether a number was prime or not in polynomial running time. The test called AKS test after the inventors: Manindra Agarwal, Neeraj Kayal and


DecReg/MiKlip gridded fields of near-surface 2m temperature and 10m wind speed for the period 2001-2010

2015 - v001, DWD Climate Data Center

Author:

Brinckmann, S.

Additional authors:

P. Bissolli

DOI:

10.5676/DWD_CDC/DECREG0110v1

Description:

This gridded fields covering Europe (CORDEX domain) have been prepared within the project DecReg/MiKlip, for the period 2001-2010, in order to generate datasets for decadal climate model validation. The data include monthly and daily mean, maximum and minimum near-surface (2m) temperature, and monthly and daily mean near-surface (10m) wind speed, together with error estimates. Input data for the gridding method are the synoptic station data from the DWD MIRAKEL database, supplemented by further station data from www.ecad.eu.Multiplex PCR amplification assay for the detection of blaSHV, blaTEM and blaCTX-M genes in Enterobacteriaceae.
Extended-spectrum beta-lactamases (ESBLs) are often mediated by (bla-)SHV, (bla)TEM and (bla)CTX-M genes in Enterobacteriaceae and other Gram-negative bacteria. Numerous molecular typing methods, including PCR-based assays, have been developed for their identification. To reduce the number of PCR amplifications needed we have developed a multiplex PCR assay which detects and discriminates between (bla-)SHV, (bla)TEM and (bla)CTX-M PCR amplicons of 747, 445 and 593 bp, respectively. This multiplex PCR assay allowed the identification of (bla-)SHV, (bla)TEM and (bla)CTX-M genes in a series of clinical isolates of Enterobacteriaceae with previously characterised ESBL phenotype. The presence of (bla)SHV, (bla)TEM and (bla)CTX-M genes was confirmed by partial DNA sequence analysis. Apparently, the universal well-established CTX-M primer pair used here


LONG BLOG

After going around the world, the Far Cry saga has finally made its way to the states. And as God is my witness, it is a beautiful sight. A sight you soon blow the shit out of!

The game takes place in the rural state of lovely Illinois, lost in a three-way civil war between two military militias and the government. After some civil unrest regarding corn oil, the whole state descended into chaos, ripe for some explosive gameplay.

You play as Dennis Halford, a rookie CIA agent sent in alongside his senior, Henry, on a recon mission. They intend to get to the heart of the debacle and possibly silence some ”unwanted” people. After an exciting car chase with alligators on rocket skates, Henry betrays you.

He needs aQ:

jQuery add class if dropdown active, else remove class

I have a script that looks if the unordered list is visible, if it is, it will add a class. My problem is, it's not removing the class. Probably a noobie error, help appreciated though.
HTML:

IT Solutions

dropdown link

dropdown link

dropdown link

dropdown link

dropdown link

dropdown link

jQuery:
$('#menu li').live('mouseenter mouseleave', function(e) {
  var element =


POST request in OpenLayers 2 to get around this issue, but I haven't found anything on how to do this using OpenLayers 3. Only a response in this post hints at a solution, but it's not enough for me to work out an answer. The following is how I'm currently defining the layer and adding the SLD. Does anyone know how to get around character limit with the OpenLayers 3 GET request by using POST instead?
window.layer = new ol.layer.Tile({
  source: new ol.source.TileWMS({
   url: 'http://' + window.location.hostname + ':8080/geoserver/wms',
   params: {LAYERS: geoserverLayer, STYLES: undefined, SLD_BODY: sld, CQL_FILER: geoserverFilter, TILED: true},
   serverType: 'geoserver'
  })
});

A:

I am not sure whether my answer is going to give you the final solution. But give it alanding, or threads the needle of an entry-corridor as it reënters Earth’s atmosphere.

That’s where Rudolf Kálmán came in. He published an ingenious recursive estimation algorithm in 1960. The filter would accomplish the goal of accurately estimating and predicting critical variables such as location, direction, and speed in the presence of noisy measurements, and even estimate the noise. Others, such as cybernetics inventor Norbert Wiener, had tackled the problem before, but Kálmán tailored his solution to the emerging world of digital computers and real-time processing.

When the Apollo 11 lunar module, controlled by Neil Armstrong and a software program, made its heart-stopping landing on the Sea of Tranquility, the Kalman filter ensured that real-time position data coming from Earth-based radar tracking agreed closely with the onboard sensors. Listen to the