they will wander off or pass away by themselves.

You Can Utilize Chalk

Much like baby powder, it's still sort of info to learn a secret why ants don't like chalk. It can assist you get rid of them without eliminating them all the exact same. The chalk doesn't injure them, however they don't like to walk over it for some reason.

Discover how they have been entering into your house and draw a line of chalk across their trail near the entrance. They will avoid it and ideally turn their entryway into an exit.

Coffee

Ants don't like the smell of coffee premises. In fact, the very same can be true for a lot of insects, including mosquitoes. Best of all, it's eco-friendly and gives you a way to recycle your usedby evaluating the chronic effects of prolonged glucocorticoid exposure on spine remodeling, functional connectivity, and anxiety. In the process, the candidate will become proficient in the use of the tools described above, leveraging prior experience with similar methods. This will be accomplished under the supervision of a team of mentors and consultants (Deisseroth, Schatzberg. Raichle, de Lecea, Barretto) who pioneered these methods and have extensive experience training others to use them. They also have highly successful track records in preparing junior investigators for the transition to independence. We anticipate that this project will yield novel insights regarding the importance of circadian oscillations in glucocorticoid activity, particularly for stabilizing dendrtic spines and preserving connectivity within limbic circuits. The results will also inform future efforts to study stress and glucocorticoid


/*
 * This header provides constants for binding nvidia,tegra210-car.
 *
 * The first 224 clocks are numbered to match the bits in the CAR's CLK_OUT_ENB
 * registers. These IDs often match those in the CAR's RST_DEVICES registers,
 * but not in all cases. Some bits in CLK_OUT_ENB affect multiple clocks. In
 * this case, those clocks are assigned IDs above 224 in order to highlight
 * this issue. Implementations that interpret these clock IDs as bit values
 * within the CLK_OUT_ENB or RST_DEVICES registers should be careful to
 * explicitly handle these special cases.
 *
 * The balance of the clocks controlled by the CAR are assigned IDs of 224 and
 * above.
 */

#ifndef _DT_BINDINGS_CLOCK_TEGRA210_CAR_H
#define _DT_BINDINGS_CLOCK_TEGRA210_CAR_H

/* 0 */
/* 1 */
/* 2 */
#define TEGRA210_CLK_ISPB 3
#define TEGRA210_CLK_RTC 4
#define TEGRA210_CLK_TIMER 5
#definelayer on the surface of the castingxe2x80x9d.
There is no disclosure of the specific extent of coating of the wafer glass base.
In Patent Abstracts of Japan vol. 014 323 (M-0997) Jul. 11, 1990 and No JP 02 108447A it is set forth that a mould core is first of all coated with a mixture of xe2x80x9cwafer glass series inorganic binderxe2x80x9d and zircon powder. Other coatings are added. When the core has been finally coated, it is fixed in the die and the casting metal material is cast around the core. The core is eventually removed, and the resulting product has a surface characteristic which it would not otherwise have without the surface coating. There is no disclosure of the extent of coating, if any, of function selecting material.
It is


package cn.iocoder.springboot.lab68.resourceserverdemo.config;

import org.springframework.context.annotation.Configuration;
import org.springframework.security.config.annotation.web.builders.HttpSecurity;
import org.springframework.security.oauth2.config.annotation.web.configuration.EnableResourceServer;
import org.springframework.security.oauth2.config.annotation.web.configuration.ResourceServerConfigurerAdapter;

/**
 * 资源服务器配置
 */
@Configuration
@EnableResourceServer
public class OAuth2ResourceServerConfig extends ResourceServerConfigurerAdapter {

    @Override
    public void configure(HttpSecurity http) throws Exception {
        http.authorizeRequests()
            // 设置 /login 无需权限访问
            .antMatchers("/login").permitAll()
            // 设置 /client-login 无需权限访问
            .antMatchers("/client-login").permitAll()
            /// 设置 /callback 无需权限访问
            .antMatchers("/callback").permitAll()
           a chunk of the season. I’ll never get used to not playing until I’m retired, and that’s a long way off, I hope.

I told the media it’s probably a little blessing in disguise, giving me a little break, but I don’t ever like watching my team play knowing I could be doing something to help us win. I hate what happened in Detroit, the whole incident. I’m still frustrated, upset about that. I was heated, and I don’t like to be like that. But I have to let it go and move forward now, try not to think about it.

I’ve been asked a lot about making the move to right field to make room for young Peter Bourjos coming up to play center. The truth is, they didn’t


come to me and say, “You’ve got to go to right field.’ They told me it was up to me. I had to think about it. I decided that if it made the team better, I was all for it. I had to think about the big picture, the long haul, and this could prolong my career, keep me on the field more. And that’s a good thing for everybody, I feel.

Bourjos is straight speed. That young man can fly. Watching him on the road trip run down some balls, even go after ones he didn’t get to, I was like, “Wow. That’s impressive.” As we play together more, I’ll know his range, what he can get to, and let him have it.

Right field is not center field.mouth about u..( i still believe u could have been a better hitter) non the less ur the greatest….and if u get a chance to read this tell the famoly i says hello and there in my prayes…ur lost but not forgotten ol pal….Leon Weathersby…..

Meta

The following are trademarks or service marks of Major League Baseball entities and may be used only with permission of Major League Baseball Properties, Inc. or the relevant Major League Baseball entity: Major League, Major League Baseball, MLB, the silhouetted batter logo, World Series, National League, American League, Division Series, League Championship Series, All-Star Game, and the names, nicknames, logos, uniform designs, color combinations, and slogans designating the Major League Baseball clubs and entities, and their respective mascots, events and exhibitions.


of our ingredients are made from animal products, by-products or
  derivatives. Our natural flavors do not contain any dairy or other
  animal products.
Are Silk products kosher?
All Silk brand products in all flavors are certified Kosher OU-D.
  Kosher OU-D certifies that a dairy-free product was heated on
  equipment also used for dairy, and designates that dairy-free products
  heated on equipment also used for dairy may not be eaten together with
  a meat product. It may be eaten immediately after a meat product, but
  not together. Since Silk products are dairy-free, why is the Kosher
  certification OU-D?
All Silk products including Silk Creamer and Silk Live! Soy Yogurt are
  completely dairy-free and safe for people with dairy allergies. While
  Silk soyEventbrite, and certain approved third parties, use functional, analytical and tracking cookies (or similar technologies) to understand your event preferences and provide you with a customised experience. By closing this banner or by continuing to use Eventbrite, you agree. For more information please review our cookie policy.

Date and Time

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Description

Meet The VC is Found.'s exclusive fireside chat series with leading VCs (Venture Capitalists) where they share their tools and insights into the local fundraising scene to get you ready for (more) investment. From seed to growth stage investing, we have got you covered with our monthly Meet The VCs series!

In our next session in our Meet The VCs series, we are going to answer any question a startup has about building a business that lasts and


foam vinyl that I then applied
to thermoplastic it's beautiful and you
know the detail on these horns is also
incredible they're super lightweight
they're all those ones are also foam
those ones are foam the part of the
reason I also picked this outfit is
because like we've been doing it for
we've been doing cosplay for like a
pretty long time and one of the things
that makes it so fun for us is it's like
all learning all the time right like
we've been doing it for like almost 20
years but every single costume I see
something and I'm like I want to do that
I want to learn how to do that technique
so I want to learn how to make on a
technique and then you find it yeah yes
so this is what I tell people you've got
to findreally
no no that's still the case this one
just happens to be weirdly good that's
awesome
do you don't pick you you document every
costume I do um I think I have one photo
somewhere
yes just go and tell me about your first
cosplay Oh God
so I was always like one of those
Halloween was like hardcore Halloween
yeah yeah yeah so she was like well
we're doing this convention in Baltimore
so come and you can wear a costume and I
was like a costume I'm sold no um so she
wanted me to be a character in this
other klump manga that hadn't actually
shown up in the manga yet so she was
like I'll just draw you a picture of
what I think it's going to look like
seeds of this nonsense and so I went to
Walmart and got dollar yard fabric


the radio exchange in the link below.

[http://audioboo.fm/boos/1482009-bolivia-air-force-fuerza-
aer...](http://audioboo.fm/boos/1482009-bolivia-air-force-fuerza-aerea-
boliviana-fab001-flight-precaution-landing-vienna-austria)

~~~
mzs
That's so strange, the FM expressed displeasure towrads the actions of
Portugal and France in quotes from the AP. I wonder if it was simply an excuse
the pilot used to not make things more complicated at that point.

------
phildeschaine
Interesting that it was written by his father's lawyer on behalf of his
father. Makes me wonder if this is the first contact his father has had with
him since this whole thing began.

~~~
mydpy
It also contains hardly any emotion (I argue that the rhetoric used in the
letter indirectly appeals to Edward). I was shocked by this.

~~~
EthanHeilman
I read an enormous amount of emotion in the letter.

------
dfc
The last paragraph reminds me of one of my favorite quotes from The West Wing:

 _" Men died for us. We had a responsibilityI would be more willing to be on his side.

~~~
jsmcgd
Has the path forward not been made clear by Snowden's revelations? It's
crystal clear to me.

~~~
embolism
Clearly the US should unilaterally stop all signals intelligence and trust all
other nations to do the same.

~~~
jsmcgd
Clearly the American intelligence services should act within the American
constitution.

~~~
embolism
Clearly some of Snowden's revelations are nothing to do with that.

------
denzil_correa
In some ways - it breaks my heart. For a moment, I imagined myself in Lon
Snowden's shoes and though I am not a parent; it took me some time to sink in
the emotion. After reading this, I do miss my father.

------
bas
How DARE he compare this to Omaha Beach, even obliquely! Many of the men in
this picture, fighting one of the greatest land armies ever assembled (the
Wehrmacht), died on this shore,


<option value="Eight">Eight</option>
                <option value="Nine">Nine</option>
            </select>
            </fieldset>
</form>

$(document).ready(function() {
        $("select#firstSet, select#secondSet, select#thirdSet").change(function(){
            var prodType = "";
            $("select#firstSet, select#secondSet, select#thirdSet option:selected");
            prodType = $(this).text();
          $("#hiddenProdField").text(prodType);
        })
        .trigger('change');
    });

A:

You'veQ:

Purpose of object in argument of Lock statement

What is the purpose of object in Lock argument. Here is an example:
public class TestThreading
{
    private System.Object lockThis = new System.Object();

    public void Process()
    {

        lock (lockThis)
        {
            // Access thread-sensitive resources.
        }
    }

}

... does this 'lockThis' object pass anything into the Lock body. Why can't I use Lock statement without object in argument.

A:

The object passed


Wednesday, February 2, 2011

Name Tattoos Ideas

If you are at loggerheads about what tattoo to get next then you must spare a thought for name tattoo ideas. This is not everyone’s cup of tea as it requires a great deal of commitment on your behalf to get someones name tattooed on your body. It certainly has to be someone who has made a huge difference in your life and it also involves the acceptance of this difference by you. This is a show of utmost loyalty, and once you have decided to go ahead with it, you can come up with hundreds of cool name tattoo ideas.

Some people even choose to get their own name tattooed on their body, and when it is merged with a good design this  self.filemenu.add_command(label="Settings")
        self.filemenu.add_command(label="About")
        self.filemenu.add_separator()
        self.filemenu.add_command(label="Exit", command=self.parent.quit)

        self.parent.config(menu=self.menubar)

        # entry search

        self.entrySearch = Entry(self.parent)
        self.entrySearch.grid(row=0, column=0, sticky=W+E)

        # button search

        self.buttonSearch = Button(text="Search")
        self.buttonSearch.grid(row=0, column=1)

        # results table

        self.resultsTable = Treeview(self.parent)
        self.resultsTable["columns"] = ("title", "artist", "length", "bitrate",


the wound within 2 months were registered at the website.

Statistical methods {#Sec8}
-------------------

The primary and secondary outcome measures were analyzed according to the intention-to-treat (ITT) and treatment received (TR) analyses. In the TR group, the protocol violations (patients not attending for the postoperative visit 1 week after surgery and surgical sites not being irrigated according to the instructions) were excluded from analyses. The means and standard deviations of normally distributed variables were calculated and analyzed by the independent-samples *t* test. Dichotomous variables were analyzed by the chi-squared or the Fischer's exact test. Logistic regression analysis was performed to identify possible risk factors for inflammatory complications. Dependent variables in each analysis that was significant at the *p* \< 0.05 were considered for the multivariate analysis. The unadjusted and adjusted odds ratios with 95 % confidence(19.1 %)0.04\*8 (8.7 %)33 (20.9 %)0.01\*Alveolar osteitis9 (5.7 %)28 (15.7 %)0.005\*5 (5.4 %)27 (17 %)\<0.001\*Moderate symptoms7 (4.5 %)18 (10.1 %)0.04\*4 (4.4 %)17 (10.8 %)0.09Severe symptoms2 (1.3 %)10 (5.6 %)0.04\*1 (1.1 %)10 (6.3 %)0.06Wound infection9 (5.7 %)6 (3.4 %)0.433 (3.3 %)6 (3.8 %)1.0*ITT* intention to treat, *TR* treatment received\*Statistically significant difference (*p* \< 0.05)

Patients with AO and surgical wound infections following third molar removal had significantly higher pain scores (*p* \< 0.0001) and worse quality of life scores (*p* \< 0.0001) for the first 7 postoperative days compared to patients without these complications (Table [2](#Tab2){ref-type="table"}). The presence of these complications resulted in a reduced mean mouth opening of 18.2 mm compared to a mean reduction of 8.3 mm in cases of normal healing 1 week after surgery. Patients proceeded with work or study after a mean period of 1.7 days in case of normal healing compared to a mean period of 3.3 days in case of inflammatory complications (*p* = 0.01)


seems plausible, sound evidence to support this theory is lacking \[[@CR3], [@CR5], [@CR42]\]. In the authors view, excessive intra-alveolar irrigation at the first day following surgery should be avoided. Theoretically, one might start the irrigation before the internal dissolution of the blood clot occurs. Birn stated that the increase in fibrinolysis is unlikely to dissolve the blood clot before the second day after surgery, since the clot contains antiplasmin, which must be neutralized before clot dissolution can occur \[[@CR4]\]. Therefore, the best moment to start the irrigation might be somewhere between the first and second postoperative day. Nevertheless, the results from this study prove that wound irrigation starting 48 h after surgical removal of the third molars is a safe procedure to perform. To prevent AO, it has beena younger age \[[@CR47]\]. Another important risk factor found in this study was the female gender. The odds of developing inflammatory complications are five times higher for female patients compared to male patients. The increased risk for female patients is found in several studies \[[@CR2], [@CR6]--[@CR9]\], while others did not find this association \[[@CR44]\]. It is suggested that the higher incidence of AO in female patients is caused by the use of oral contraceptives. Estrogen in oral contraceptives has shown to cause elevated plasma fibrinolytic activity \[[@CR48]\], which could in turn cause earlier lysis of the blood clot \[[@CR3]--[@CR5]\]. The multivariate regression analysis in this study, however, did not show any effect of the use of oral contraceptives on the occurrence of postoperative complications following third molar removal.


tap water. Starting 48 h after surgery, using a curved tip Monoject® syringe and rinsing four times a day during 5 days seems to be an effective protocol for this commonly performed surgical procedure. Special care should be provided on the postoperative instructions how to use the syringe.

Appendix {#Sec13}
========

Table 4Baseline characteristics for intention-to-treat analyses and treatment received analysesITT analysesTR analysesMonoject® (*n* = 158)Control (*n* = 175)*p*Monoject® (*n* = 91)Control (*n* = 158)*p*Demographic variables Age0.880.76  18--2510911964107  26--3536461742  36--459776  46--552121  56--651101  \>650101 Gender0.250.58  Female9912159109  Male58543149 Race0.830.42  Caucasian13714086140  Other1012412 Education level0.250.39  Primary education15878  Secondary vocational (MBO)51493149  Higher professional (HBO)51533653  University29411641Health status variables ASA classification0.0520.047  113015873143  2 or \>227171715 Diabetes mellitus (yes)111.0011.0 Immune deficiency (yes)0000 Other chronic condition, medical treatment (yes)850.39441.0 Oral contraceptive drugs (yes)57800.3034710.48 Current smoking (yes)18230.7411201.0 Current alcohol (\>3 days)300.10200.13 Oral hygiene0.350.41  Good12415080137  Poor1312411  Bad0202Anatomic variables Angulation of the third molar^a^0.690.68  Vertical49543050  Disto-angular1018617  Mesio-angular75794170  Horizontal21201217  Transverse1303 Depth of impaction^b^  Tooth covered by anterior border of the ramus0.350.16   Class I59553952   Class II901104796   Class III9959  Depth of impaction to the adjacent tooth0.160.067Class A28431437   Class B1071095999   Class C23221821Surgical variables Experience surgeon0.480.43  \<100 M3 removed511311  101--500 M3 removed1416716  501--1000 M3 removed1616914  1001--3000 M37867  \>3000 M3 removed11612366109  Resident68770.8339700.89  Senior staff90975287 Type of incision0.350.08  Envelope45492544  Triangular1041096298  Other6130.24112 Removal of buccal  }

    addEventListener(type, handler){
        let handlerAll = this.handlers[ type ];

        if( ! handlerAll){
            handlerAll = this.handlers[ type ] = [];
        }

        handlerAll.push( handler );
    }
    removeEventListener(type, handler){
        let handlerAll = this.handlers[type];

        if(handlerAll){
            let index = handlerAll.indexOf( handler );

            if(index > -1){


of Ruskin College
Category:Amalgamated Society of Woodworkers-sponsored MPs
Category:British trade unionists
Category:Labour Party (UK) MPs for English constituencies
Category:Mayors of places in Greater London
Category:People from Plymouth
Category:People from Willesden
Category:UK MPs 1923–1924
Category:UK MPs 1924–1929
Category:UK MPs 1929–1931
Category:UK MPs 1935–1945
Category:UK MPs 1945–1950
Category:UK MPs 1950–1951
Category:UK MPs 1951–1955
Category:UK MPs 1955–1959
Category:Councillors in Greater London
Category:Commanders of the Order of the British Empireit was previously started (the user can still force the cluster to
start with neoctl). And any lost node during verification also causes the
master to go back to recovery.
Obviously, the protocol has been changed to split the LastIDs packet and
introduce a new Recovery, since it does not make sense anymore to ask last ids
during recovery.

Currently, the database may only be truncated when leaving backup mode, but
the issue will be the same when neoctl gets a new command to truncate at an
arbitrary tid: we want to be sure that all nodes are truncated before anything
else.
Therefore, we stop sending Truncate orders before stopping operation because
nodes could fail/exit before actually processing them. Truncation must also
happen before asking nodes their last ids.
With this commit, if a truncation is requested:
- this is always the


results.

Elasticsearch has quite a few features. Most of them are implemented
by Elastic. I add features and APIs as required. It's straightforward
to implement missing pieces. I'm accepting pull requests :-)

Having said that, I hope you find the project useful.

## Getting Started

The first thing you do is to create a [Client](https://github.com/olivere/elastic/blob/master/client.go).
The client connects to Elasticsearch on `http://127.0.0.1:9200` by default.

You typically create one client for your app. Here's a complete example of
creating a client, creating an index, adding a document, executing a search etc.

An example is available [here](https://olivere.github.io/elastic/)

Here's a [link to a complete working example for v3](https://gist.github.com/olivere/114347ff9d9cfdca7bdc0ecea8b82263).

See the [wiki](https://github.com/olivere/elastic/wiki) for more details.

## API Status

### Document APIs

- [x] Index API
- [x] Get API
- [x] Delete API
- [x] Delete By Query API
- [x] Update API
- [x] Update By Query API
- [x] Multi GetQualitative assessment of agritourism safety guidelines: a demonstration project.
In 2007, the National Children's Center for Rural and Agricultural Health and Safety (NCCRAHS) published Agritourism Health and Safety Guidelines for Children to provide helpful recommendations for protecting the health and safety of children visiting agritourism farms. Supplement A: Policies and Procedures Guide and Supplement B: Worksite Guide were subsequently published in 2009 and provided agritourism farms with checklists to use in reviewing, planning, and implementing their own health and safety practices. In order to better understand what would be required of a farm wishing to implement the guidelines using Supplements A and B, the North Carolina Agromedicine Institute conducted a single-family farm demonstration project with support from the NCCRAHS. The aims of the project were to (1) determine child


of certain types of cancer because trace amounts of mesothelin can be detected in the blood of some patients with mesothelin-positive cancers (Cristaudo et al., Clin. Cancer Res. 13:5076-5081, 2007). It has been reported that mesothelin may be released into serum through deletion at its carboxyl terminus or by proteolytic cleavage from its membrane bound form (Hassan et al., Clin. Cancer Res. 10:3937-3942, 2004). An increase in the soluble form of mesothelin was detectable several years before malignant mesotheliomas occurred among workers exposed to asbestos (Creaney and Robinson, Hematol. Oncol. Clin. North Am. 19:1025-1040, 2005). Furthermore, patients with ovarian, pancreatic, and lung cancers also have elevated soluble mesothelin in serum (Cristaudo et al., Clin. Cancer Res. 13:5076-5081, 2007; Hassan et al., Clin. Cancer Res. 12:447-453, 2006; Croso et-- a full confession -- and we squash the CIA business." "Take the night to think it over." "Sleep well." "Burn Notice 6x06 Shock Wave Original Air Date on July 26, 2012" "== sync, corrected by elderman ==" "Seven phone calls, four texts, and two cryptic e-mails, all to set up an urgent cloak-and-dagger meeting in the woods." "I think you enjoy being a spy a little too much, Michael." "I think you need a hobby, and I " "I know where we can find Anson Fullerton." "Excuse me?" "He's been getting cash and fresh travel documents every couple of weeks." "He's picking up a new package tomorrow in a motel in Atlantic City." "And how do you know this?" "The point is, I know it." "Hold on,


it once in Beirut." "Oh, hold on." "We got Nate Westen to the rescue." "Hey, whose room is this?" " Damn it." " What the hell is he doing?" "What you think you're doing, dude?" "You're in my ride." "Oh, yes." "I'm very sorry about that." "And I will be brief." "We're gonna need all your linens." "What'd you say?" "Well, I'm the assistant manager." "And -- oh!" "This is Manny." "And unfortunately -- and I don't want to alarm anyone -- but we've had a massive bedbug infestation." "Bedbugs?" "Bedbugs." "You serious right now?" "Yo!" "Farrah!" "Bova!" "We gots to roll, kids." "Manny says the place got bedbugs." "I ain't paying' for the room." "You can forget that, yo." "Yes, I understand." "And I'm very sorry foryour brother." "Fiona's life is on the line, Jess." "I can't have Nate -- there is no margin for error on this." "Yeah." "Guard Rodriguez, call 776." "Nice touch." "Cheaper than a lookout." "More reliable." "Never met a cup of rocks that would betray me." "Inmate 239..." "You're about to see why I got myself on library detail." "I had my guard on cell block "D" kill their AC unit." "Nobody's gonna miss this." "Strip check "B," to the office." "Strip check "B," to the office." "Come on." "We gotta make room for your bony ass." "Just me and a year's supply of menthols, huh?" "Hey." "You get claustrophobic, you bite your knuckle and keep it to yourself." "If you get busted before I can play the hero,"


"Let's go." "Is calling it that supposed to make me feel better?" "You know, it's just a beer can with aquarium cleaner and sugar and " "I know what I'm doing." "Does that make you feel better?" "Let's do it." "Hey, how long is it gonna take for you to get this boomstick thing ready?" "A minute." "Minute?" "I don't think we have a minute, man." "They're coming." "Mr. Hartley, before you take another step," "I'd like to talk terms." "Good." "There's no reason we can't be professional about this." "I agree." "So I'm gonna offer you one last chance." "If you forfeit your guns, we'll drop the weapons charges." "If you don't, a federal prosecutor is gonna step on your neck as hard as he can." "Don'tto talk to you about." "I'm up for parole in three months." "You're up for rejection in three months." "Well, no." "Not this time." "This time, I'll have a letter of support from you." "Why?" "Because you ratted out two chickenheads planning a riot?" "Because I know where Fiona Glenanne is." "And soon as that's signed and faxed to my lawyer, you will, too." "Get out of there!" "Come here!" "Aah!" "I bet you think you're awfully clever." "But your British friend is just going to fly back and make another appointment." "Well, he better hurry." "Ayn's not the only one expecting an early release." "Put them both in solitary." "Going left." "Okay." "Up ahead, around the corner." "Safety your weapons, but be prepared." "I want Anson alive,


sense earlier. I shouldn’t give people my phone number. I should get a new one and only tell a few people I have it. I could pretend to be even more pretentious than I already am and say things like “I just feel that I’m above this whole phone fad.”

I’m going to lean into this freedom from unnecessary obligations and awkward conversations. I can’t afford a new phone for a while, and I don’t really want to now. I’m not closer to living out my wilderness daydreams, but if people I don’t like can’t make my pocket vibrate anymore, then I don’t really need the woods. I could just stand near a potted plant and continue not buying a new phone.

I’m right there with you. To be honest,of data for the utility monitors; and transmitting the combined set of data to a utility data collection device.
In yet another embodiment of the invention a system is provided which comprises providing a plurality of utility monitors; transmitting at a low power level data for each utility monitor to a proximate utility monitor; creating a combined set of data for all of the utility monitors; and transmitting the combined set of data at a high-power level to the utility data collection device. The various embodiments of the invention have features which are interchangeable. For example, in the embodiment where information is transmitted at low power, the information also can be transmitted in a serial fashion between the plurality of utility monitors in a daisy chain fashion.
The utility data


collection device can utilize a high-power transmitter, such as a cellular transmitter, to communicate directly with the utility center which processes data for all of the utility system. Similarly, the utility collection device can also communicate with utility monitors having a high-power transceiver.
One embodiment of the invention allows for the processing of error information. The individual utility monitors can gather error information and transmit it through the chain of neighboring utility monitors or directly to the utility data collection device or utility center. Similarly, the communication network can allow for the order of a serial chain of utility monitors to be altered from data gathering session to data gather session. In this way, individual utility monitors can be removed from the data gathering process. Additionally, a more efficientRifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature.
Exacerbation of alcoholic hepatitis (AH) with comorbid metabolic syndrome is an emerging clinical problem, where microbiota plays a profound role in the pathogenesis. Here, we investigated the effect of rifaximin (RFX) on liver injury following chronic-binge ethanol (EtOH) administration in KK-Ay mice, a rodent model of metabolic syndrome. Female, 8-wk-old KK-Ay mice were fed Lieber-DeCarli diet (5% EtOH) for 10 days, following a single EtOH gavage (4 g/kg body wt). Some mice were given RFX (0.1 g/L, in liquid diet) orally. Small intestinal contents were collected from mice without binge. Intestinal microbiota was quantified using aerobic and anaerobic culturing techniques and further analyzed by 16S rRNA sequencing in detail. EtOH feeding/binge caused hepatic


" Do you speak English?" " Well, I do my best." "Just the woman I need." "The mobilization started two days ago." "They're distributing gas masks." "Is it the same in your country?" "Yeah." "But there's a channel between us and you lot." "You knew him?" "Yeah." "I was working with him as an interpreter." "He often spoke about you and Angela." "Working?" "But he retired three years ago." "He told my father he was on a case." "I thought he was with his sister in Wales." "Put those down." "Daddy, might we have time to go to the beach?" " How long are you staying?" " Just until tomorrow." "This woman, is she the center of his investigation?" "Officially, no." "I don't understand it." "If Joe wasit." "No one." "For a child to be responsible for the death of his own twin... at such a tender age." "Imagine the horror of that." "Carry me." "You're still young, Inspector." "I hope one day you'll discover there is more to truth and justice than mere reason." "There's impulse and chaos... the human animal, the human heart." "Yeah, I know, it's part of my job." "So that's what keeps you so cool." "The bride-to-be, my daughter, Celia." "Just returned from the United States." "Celia, let me present Inspector Cross from London." "He's here for the funeral of a close friend." "I'm so sorry." "How do you do?" "You can put me down." "And this is Mr. Christopher Wood from Wisconsin." "He's Celia's new fiancé." "New?" " It's


"He wasn't crazy, you know." "There was some thing about this family that he just couldn't let go." "The daughter's fiance was killed in a car crash three years ago." "Joe seemed convinced it was a murder... but that wasn't why he stayed and stayed." "Are you part of the police or what?" "Officially, no." "I just help my father from time to time." "Pardon." "So sorry to be late." "Mr. Montfort, the Department prefect, also my father." " This is Inspector Cross." " Enchanté." "How do?" "Good." "Joe Green, how did he die?" "Suicide, without question." "His own gun." "No suspicious circumstances... but if you like to check again, you have all my blessings." "Right." "What's he saying?" "He says he'll be delighted to have dinner withme." " You're still sure you want to get married?" " Of course." "You're like a little boy." "Now, five more nights, that's all." "Delicious agony." "Jeremy, you frightened me." "A wedding gift." "Now you're absolutely perfect." "How beautiful." "Thank you." "To remind you of me." "Jeremy, we're not children any more." "Why not?" "My little hot-water bottle." "Better now?" "A little." "Who is it?" "Christopher, let me in." "It's very bad luck to see the wedding dress before the big day." "If you want to talk to me, I'll be awake." "Don't touch me." "I don't want any more." "I'm marrying Christopher in six days time." "We're leaving straight away for New York." "I won't let you." "I don't want to see you again, Jeremy." "Ever." "I


one of them!" "You think I can cover up for you?" "What kind of man do you think I am, for Christ's sake?" "What can I do now?" "It's too late." "Unless you're lying to me." "Unless you weren't there." "Unless your brother killed Helena on his own." "Just say the word and you'll be released." "Say it." "Don't let me die." "Banjo ur." "You're coming with me." "Come on!" "All right." "You're on your own." "Move." "There's a train for Le Havre in ten minutes." "From there you can go back to New York." "Go." "Move!" "Celia." "I'm lost." "I need you." "Both our lives are over." "We're one person, you and I." "Twins." "Silence!" "Get back!" "Stay back!"More than 50 percent of employees in Taiwan are concerned about losing their jobs as a result of the development of artificial intelligence technology, according to a survey by 1111 job bank.

The poll showed that about 51.19 percent of Taiwan workers are worried about being replaced by robots in an AI era, particularly in the fields of education and trade/logistics.

Among those who have such concerns, 42.06 percent think that because of their age, they would have difficulty finding a new employment if they lose their jobs as result of AI, according to the poll, which showed that such fears are most prevalent among employees in the 45-50 age group.

Only about 7.71 percent of employees in Taiwan have taken steps to upgrade their skills in an effort to adapt


# -*- coding: utf-8 -*-

# This code is part of Amoco
# Copyright (C) 2006-2011 Axel Tillequin (bdcht3@gmail.com)
# published under GPLv2 license

# import expressions:
from amoco.cas.expressions import *

# 64bits registers :
# -------------------

rax = reg("rax", 64)  # accumulator for operands and results data
rbx = reg("rbx", 64)  # pointer to data in the DS segment
rcx = reg("rcx", 64)  # counter for string and loop operations
rdx = reg("rdx", 64)  # I/O pointer
rbp = reg("rbp", 64)  # pointer to data in the stack (SS segment)
rsp = reg("rsp", 64)  # stack pointer (SS segment)
rsi = reg("rsi", 64)  # ptr to data in segment pointed by DS; src ptr for strings
rdi = reg("rdi", 64)  # ptr to data in segment pointed by ES; dst ptr for strings
rip =the measurement target 30, too, changes as the temperature changes. Accordingly, based upon the change in the optical path length L at the measurement target 30, the temperature at the measurement target can be measured along the depthwise direction.
As the temperature of the measurement target 30 being heated with a heater or the like changes as shown in FIG. 33, the measurement target 30 expands, as indicated by the one-point chain line. At this time, the refractive index n of the measurement target 30, too, becomes altered and, as a result, the interference waveform position following the temperature change shifts relative to the position prior to the temperature change, which changes the interval between the peak positions, as shown in FIGS. 33A and 33B. The extent to which


Q:

How do I remove all punctuation that follows a string?

It's for a game in which the user can input a value like "Iced tea.."
I would like to manipulate the string to return "Iced tea" without the trailing punctuation marks.
Looking for most elegant / simplest python solution.
Tried
def last_character(word):
  if word.endswith('.' or ','):
      word = word[:-1]
  return word

which works if there's only one punctuation mark at the end. But it's not all-encompassing.
Found a Java solution:
String resultString = subjectString.replaceAll("([a-z]+)[?:!.,;]*", "$1");

A:

>>> 'words!?.,;:'.rstrip('?:!.,;')
'words'

Let $\ell$ be a prime power and let $r$ be an odd integer. Let $\cX$ be the curve defined over $\FF_{\ell^{2r}}$ by the affine equation $$x^{\ell^r+1}=y^\ell+y.$$ This curve has genus $\ell^r(\ell-1)/2$. Let $P_\infty$ be the point at infinity $(0:1:0)$ of $\cX$ and let $P_{0b_j}$ be the points $(0:b_j:1)$ with $b_j\in \FF_{\ell^{2r}}$ in such a way that $b_j^\ell+b_j=0$ for $j=1,\ldots,\ell$. Observe that $$\operatorname{div}(x)=\sum_{j=1}^\ell P_{0b_j}-\ell P_\infty \quad \mbox{and} \quad \operatorname{div}(y-b_j)=(\ell^r+1)(P_{0b_j}-P_\infty) \ \mbox{for } j=1,\ldots,\ell.$$ Hence, $a=\ell$ and $b=\ell^r+1$. Therefore, according to Theorem \[result\] and Theorem \[maximals\], the generalized Weierstrass semigroup $\hH(P_\infty,P_{0b_1},\ldots,P_{0b_{m-1}})$ for $2\leq m\leq \ell^r+1$, is completely determined by $\ell^r+m$ elements of $\hGamma(P_\infty,P_{0b_1},P_{0b_2},\ldots,P_{0b_{m-1}})\cap \cC_m$ and $\Theta(P_\infty,P_{0b_1},\ldots,P_{0b_{m-1}})$. For instance, if $\ell=5$, $r=1$, and $m=3$, the Hermitian curve of genus $10$, $$(0, 0, 0), (13, 1, 1), (8, 2, 2),  (3,


Theorem \[maximals\] and Theorem \[result\], we have that the elements of $\hGamma(\negP_m)$ are exactly the $m$-tuples of the following types:

\(I) $ \ (-ai+b(a+1-m-t_1),i+b(t_1-t_2),\ldots,i+b(t_{m-2}-t_{m-1}),i+bt_{m-1})$;

\(II) $ \ (-bt_1,b(t_1-t_2),\ldots,b(t_{m-2}-t_{m-1}),bt_{m-1})$,

where $1\leq i<b$ and $t_j\in \ZZ$ for $j=1,\ldots,m-1$. As Theorem \[dimension\] gives ${\ell(D_{\negalpha} )=\#\left(\hGamma_{\negP_m}(\negalpha)/\equiv_1\right)}$, we will count ${\#\{\beta_1 \ : \ \negbeta=(\beta_1,\ldots,\beta_m)\in \hGamma_{\negP_m}(\negalpha)\}}$.

To do that, let us first count $\#\{\beta_1 \ : \ \negbeta=(\beta_1,\ldots,\beta_m)\in \hGamma_{\negP_m}(\negalpha) \ \mbox{of type (I)}\}$, that is, $$\label{eq:absmaxalphaI}
\begin{array}{l}
\beta_1=-ai+b(a+1-m-t_1)  \leq   \alpha_1,\\
\beta_j=i+b(t_{j-1}-t_j) \leq  \alpha_j , \qquad \mbox{for} \qquad j=2,\ldots,m-1, \\
\beta_m=i+bt_m\leq \alpha_m.
\end{array}$$ Writing $d_j=t_{j-1}-t_j$ for $j=2,\ldots,m-1$, and $d_m=t_{m-1}$, we obtain $t_1=\sum_{j=2}^{m}d_j$. We may thus rewrite as $$\label{eq:absmaxe}
\begin{array}{l}
\beta_1=-ai+b(a+1-m-\sum_{j=2}^m d_j)  \leq   \alpha_1\\
\beta_j=i+bd_j \leq  \alpha_j  \qquad \mbox{for} \quad j=2,\ldots,m.
\end{array}$$ Hence we must compute the number of distinct values ${-ai+b(a+1-m-\sum_{j=2}^m d_j)}$, where the $d_j$’s satisfy the constraintsstress (Fig. [S2](#MOESM3){ref-type="media"}).

Quantification of the percent of cells with eIF2B bodies and the total pHuji intensity in the GCD1-GFP strain over a 15-minute time-lapse image series after glucose repletion showed that eIF2B body disassembly corresponds with a rapid increase in cytoplasmic pH (Fig. [S2](#MOESM3){ref-type="media"} and Video [S2](#MOESM2){ref-type="media"}). Therefore, a dynamic reduction in cytoplasmic pH upon glucose deprivation is associated with eIF2B body formation.

EIF2B bodies assemble and disassemble independently of stress granules {#Sec4}
----------------------------------------------------------------------

Glucose deprivation stress also induces the formation of SGs: RNA-protein aggregates that are enriched in translation factors. However, although SGs and eIF2B bodies are both induced by long-term starvation, growth and glucose deprivation, and both foci harbor translation factors, the relationship between SGs and eIF2B bodies has not been evaluated to date. To determine if eIF2B bodies are related temporally


post-glucose repletion (Fig. [3b](#Fig3){ref-type="fig"}). Taken together, our findings demonstrate that although eIF2B bodies and SGs form under similar conditions, they are likely regulated through distinct pathways, have differential sensitivity to translation and energy status in the cell, and/or have distinct biophysical properties that contribute to their differential disassembly kinetics.Figure 3Stress granules induced by glucose deprivation stress dissolve before eIF2B bodies upon glucose repletion. Strains with endogenously GFP tagged *SUI2*, *GCN3*, *GCD1* and *GCD2* were transformed with a stress granule marker plasmid PUB1-mCherry and imaged under a 1% agarose pad on a spinning disc confocal microscope (100×). A solution of 10% glucose was added at time 0 and cells were imaged every 15 seconds for 15 minutes. (**a**) Graphs show the time (minutes) until stress granules ("SG") and eIF2B bodies ("2B bodies"deprivation stress *GCD7* V341D and *GCD7* E239G strains had increased levels of P-bodies (Fig. [7a](#Fig7){ref-type="fig"}), which could also be due to increased translation repression under these conditions due to these alleles. Since the size of P-bodies reflects the association of mRNAs with the mRNA degradation machinery, an increase in P-bodies due to certain eIF2B mutations implies that these mutations alter the degradation rates of some mRNAs.

To examine if VWMD mutations could also affect P-bodies in human cells in culture, we examined immortalized lymphoblasts derived from two siblings with VWMD harboring *EIF2B2*^*E304X*^ mutations. We observed that P-bodies were significantly increased in VWMD patient cells under normal growth conditions compared to those from age and sex matched healthy controls (Fig. [7c](#Fig7){ref-type="fig"}). Thus, VWMD mutations can cause an increase in P-bodies in both


video, and their latest replaces those lovable, huggable Wild Things with a group of dirty hipsters from Los Angeles. Poor Max in his cute, white animal outfit -- all he wants to do is throw mud and start a Wild Rumpus, but the Dirty Hipsters are too busy bumming smokes, compiling mix CDs featuring indie bands you've never heard of and going to see Fellini movies at the Art House.

It's probably a touch funnier if you're familiar with Los Angeles culture, but every city has their collection of hipsters and so I'm fairly certain you'll all "get" this in one way or another.Welcome To
Hoteles Royal

Discover Colombia, Chile and Ecuador through our luxurious hotels

Hoteles Royal. A world of friendliness

With twenty luxury hotels located throughout Colombia, Chile and Ecuador, Hoteles Royal welcomes you to leave the ordinary behind and uncover the perfect travel destination - whether you seek a welcoming home away from home for family holidays, a modern and elegant address for conducting business in style, or a relaxing retreat for weekend getaways.

All Hoteles Royal hotels are strategically located within their cities, offering effortless access to Colombia, Chile and Ecuador’s top corporations, attractions and shopping, nightlife and entertainment areas. Each hotel is as unique and dynamic as the city it serves, and each caters to the needs of discerning executive and leisure travelers with a dedication personalized service practiced by the


grind size. The larger the surface area, the longer it takes for the water to extract the coffee out of the bean.

What is the proper water to grinds ratio for French press coffee?

In a French press, you want to be brewing at a ratio of four parts water to one part coffee. Pour the water over the grinds and let the coffee brew for four minutes. If you stir the coffee a few times you can speed the total brewing time up, but it’s not necessary to make a delicious French Press.

Can you burn coffee in a French press?

You can burn coffee and create an acrid brew if you use water that’s boiling. To ensure you’re using coffee at a perfect temperature, bring your water to a boil.percent of the entire pig population in the United States.

-Just off the west coast of the United States, a wide variety of sea creatures are dying in unprecedented numbers. For example, the sardine population along the west coast has dropped by a staggering 91 percent just since 2007.

-Down in Florida, citrus greening disease is absolutely crushing the citrus industry. Crops just keep on getting smaller year after year.

Are you starting to see what I am talking about?

In many years, the world already eats more food than it produces. We don’t have much room for error, and there are some countries that are already experiencing a full-blown food crisis. The nation of Guatemala is one of them…

Nearly one million people in Guatemala are struggling to feed themselves as poor


It is an honour to be bringing Philip Pullman's extraordinary novels to BBC One. His Dark Materials is a stunning trilogy, and a drama event for young and old.

Commissioned by Charlotte Moore, Controller BBC One and Polly Hill, Controller BBC Drama Commissioning, His Dark Materials is produced by Bad Wolf and New Line Cinema which will be made in Wales for BBC One.

Polly Hill, Controller BBC Drama Commissioning, says: "It is an honour to be bringing Philip Pullman's extraordinary novels to BBC One. His Dark Materials is a stunning trilogy, and a drama event for young and old - a real family treat that shows our commitment to original and ambitious storytelling."

His Dark Materials is one of the supreme works of imaginative fiction for both children and adultsaverage paw withdrawal latency at 10 ± 2 s. At specified time points, paw withdrawal latencies were measured in duplicate for each paw. A minimum inter-trial interval of 5 min was allowed between evaluations of the paws. Testing took place with the following order: right, right, left, and left. If the mouse did not respond within 30 s, the heat was discontinued to prevent tissue damage.

### Neurological motor function

We monitored animals as they walked across a flat plane and checked their righting reflex after turning them over. Responses were scored according to the following clinical assessment scale \[[@B31]\]: grade 0, absence of clinical signs; grade 1, hanging tail or impaired righting; grade 2, mild paresis of one hind limb; grade 3, paresis of two hind limbs; and grade 4, full paralysis of one


                   Mechanical thresholds                          Figure [2](#F2){ref-type="fig"}A                           Day: *F*~9,198~ = 4.2, *P* \< 0.001                    Figure [2](#F2){ref-type="fig"}B               are similar between 3--4-month-old female and male C57BL/6 mice.** Administration of the EAE-inducing agent myelin oligodendrocyte glycoprotein 35--55 (MOG~35-55~) was associated with neurological motor deficits as assessed with a clinical scoring system in female **(A)** and male **(B)** mice. Weak effects were also observed on grip strength (**C** and **D**, but see Figure [3](#F3){ref-type="fig"}B for significant effects at later time points). No differences in body weight were observed between the animals that received MOG~35-55~ versus CFA in either female **(E)**or male**(F)** mice. MOG~35-55~ injections began on day 0. *BL* baseline. Values represent mean ± SEM. ★*P* \< 0.05 compared to sex- and age-matched CFA control (one-way ANOVA). *N* = 10--13/group.](2042-6410-5-4-1){#F1}

![**EAE induces mechanical and cold hypersensitivity in female, but not male C57BL/6 mice.** Administration of MOG~35-55~ increased sensitivity to mechanical and cold stimulation in females (**A**


and **C**, respectively), but not their male counterparts (**B** and **D**, respectively) relative to CFA sex- and age-matched controls. MOG~35-55~ did not alter paw withdrawal latencies in response to radiant heat in either female **(E)** or male **(F)** mice as compared to CFA age- and sex-matched controls. Area under the curve (AUC) analyses on days 7--21 examining sensitivity to mechanical **(G)** and cold **(H)** and days 10--16 examining thermal stimulation **(I)** in females *(F)* and males (*M*). MOG~35-55~ injections began on day 0. *BL* baseline. Values represent mean ± SEM. ★★★*P* \< 0.001, ★★*P* \< 0.01, and ★*P* \< 0.05 compared to sex- and age-matched CFA control (one-way ANOVA) or comparison as indicated in AUC figures (one-way ANOVA and Bonferroni Correction). *N* = 10--13/group.](2042-6410-5-4-2){#F2}

### Experiment 2

Data were analyzed with a two-way RM ANOVA comparing treatment (MOG~35-55~ vs. CFA)              (Figure [5](#F5){ref-type="fig"}H)

Treatment conditions: CFA, *n* = 17; CFA + MOG~35-55~, *n* = 18. Estrous phase: proestrus (*n* = 4--18/day) or non-proestrus phases (*n* = 17--30/day). *AUC* area under the curve.

The Greenhouse-Geisser correction was applied to all RM ANOVAs, where the epsilon value from Mauchly's test of sphericity was \<0.75, and the significance level was *P* \< 0.05 (the assumption of sphericity was violated). In these cases where the Greenhouse-Geisser correction factor was applied, degrees of freedom reported reflect the uncorrected values. AUC data were analyzed with one-way ANOVAs followed by Bonferroni correction. SPSS 19.0 (SPSS Inc., Chicago, IL, USA) statistical software was employed. *P \<* 0.05 was considered statistically significant.

Results
=======

Experiment 1: sex differences in the EAE model
----------------------------------------------

### MOG~35-55~ produces neurological motor dysfunction in both females and males

#### Clinical scores

As


values as compared to non-proestrus in CFA controls (*P* \< 0.01; one-way ANOVA; Figure [5](#F5){ref-type="fig"}D).

#### Mechanical hyperalgesia

MOG~35-55~ reduced mechanical thresholds on days 7, 21, and 29 (*P* \< 0.05; Table [3](#T3){ref-type="table"}). When the data was transformed as AUC, we found a main effect of MOG~35-55~ (*P* \< 0.01; Table [3](#T3){ref-type="table"}; Figure [5](#F5){ref-type="fig"}E,F)~.~ On day 29, two-way ANOVA revealed an effect of estrous (*P* \< 0.05; Table [3](#T3){ref-type="table"}) and an estrous-by-treatment interaction (*P* \< 0.01; Table [3](#T3){ref-type="table"}; Figure [5](#F5){ref-type="fig"}E); however, we caution against over-interpretation of this result since this occurred at just one time point, and AUC transformation yielded no effect of estrous over multiple testing days.

#### Cold hyperalgesia

MOG~35-55~ increased the response to cold stimulation on days 13, 21, 29, and 42 (*P* \< 0.05; Table [3](#T3){ref-type="table"}; Figure [5](#F5){ref-type="fig"}G). Although we found an interaction of treatment by estrous on day 42 (*P* \< 0.05; Table [3](#T3){ref-type="table"}), the conclusions are tentative as there was2:1 prevalence in females relative to males. Our study tested the hypothesis that neurological motor impairment would be greater in females in the most commonly utilized animal model of MS, the mouse MOG~35-55~ EAE model \[[@B21],[@B28],[@B40]\]. As described previously, we found that MOG~35-55~ produced motor dysfunction, characterized by mild paralysis of one or both hind limbs \[[@B28]\], for review see \[[@B41]\]. And, in agreement with one previous study \[[@B33]\], we found that MOG~35-55~ decreased grip strength, an effect most evident 2--3 weeks after initial immunization. This robust behavior persisted in females for up to 42 days post-immunization (Figure [3](#F3){ref-type="fig"}B).

Similar to the results of Okuda and colleagues, we found that MOG~35-55~ produced motor impairments and decreases in grip strength in both male and female C57BL/6 mice, indicating an absence of sex differences


the coffin.

Why you shouldn't ask it: As my friend and colleague Heina put it: "'Have you heard of Jesus?' No, actually, I was born under a fucking rock."

Are you really not aware of how dominating a force religion is in society? In most of the world, and certainly in the United States, religion is impossible to ignore. It permeates the social life, the economic life, the cultural life, the political life. We're soaking in it. The idea that atheists might somehow have come to adulthood without being aware of the Bible, of stories about supposed miracles, of stories about personal religious experiences… it's laughable. Or it would be laughable if it weren't so annoying. Religious privilege is all over this question like a cheap suit.

8: "What if you'rehis followers is an insincere, self-serving, "wink wink, I'm covering my bases" version of "belief"?)

9: "Why are you atheists so angry?"

The answer: I've actually written an entire book answering this question (Why Are You Atheists So Angry? 99 Things That Piss Off the Godless). The short answer: Not all atheists are angry about religion — and those of us who are angry aren't in a constant state of rage. But yes, many atheists are angry about religion — and we're angry because we see terrible harm being done by religion. We're angry about harm being done to atheists… and we're angry about harm done to other believers. We don't just think religion is mistaken — we think it does significantly more harm than good. And it pisses us


“basic facts” of American life, and as perpetually mistrusted news organizations tried to fact check on shoestring budgets, the responsibility for combating fake news in an increasingly fragmented knowledge ecosystem has belonged to Facebook. But the sprawling social network’s efforts to combat bad satire and conspiratorial kudzu may be for naught: While more and more Americans get their news from Facebook, only 18 percent say they believe or trust what they’re reading, according to a BuzzFeed/Ipsos poll.

Wikipedia’s role in beating back the post-truth age doesn’t rest with blacklisting certain sources as perpetually unreliable (as the website did with the Daily Mail) or preventing congressional staffers from meddling with their boss’ bios. An elder statesman of the content ecosystem in Internet years, Wikipedia has been combating misinformation by thoughtfullyyears, and we’ve developed very extensive policies for determining what is a reliable source or not. When students go through the process of contributing to the site, they figure out how to write neutral, fact-based entries, and they have to disclose all of their sources. The debate we’ve seen recently has only crystallized for us that the skills we teach through the program are vitally important.”

We generally think of the Internet not as a global commons but as a series of self-segregating (although not all-encompassing) epistemic bubbles with their own senses of right and wrong, maintained by unique networks and memes. But Wikipedia doesn’t create the same sort of political polarization we’ve come to expect from vast online communities: An October working paper from the National Bureau of


476 So.2d 40 (1985)
COLLEGE ART THEATRES, INC., a Corporation
v.
STATE of Alabama, ex rel. John Paul DeCARLO, District Attorney for the Tenth Judicial Circuit of Alabama.[1]
ANWAR ENTERPRISES, INC., a Corporation, d/b/a Birmingham Adult Books
v.
STATE of Alabama, ex rel. John Paul DeCARLO, District Attorney for the Tenth Judicial Circuit of Alabama.
83-401, 83-402.
Supreme Court of Alabama.
June 28, 1985.
Rehearing Denied August 30, 1985.
*41 Ferris S. Ritchey, Jr., of Ritchey & Ritchey, Birmingham, for appellants.
John Paul DeCarlo, Dist. Atty., pro se.
PER CURIAM.
These two cases arise under the Alabama Red Light Abatement Act, Code 1975, § 6-5-140, et seq. After finding that defendants permitted and effectively encouraged their patrons' lewd conduct in their adult motion picture theaters, the trial court granted permanent injunctions prohibiting defendants from operating their premises as motion picture theaters orexample. The header should be provided in the first line of the csv file. And rename the report.txt to report.csv.
import pandas as pd
import random

path_csv = '/home/mahmoudod/Desktop/Tareq-Qassrawi/report.csv'
df = pd.read_csv(path_csv, header=0)
df.head()


first-hand any of the painful, negative effects the cats shown in the film have sadly experienced. Feel free to watch and decide for yourselves. My strongest reservation among these new releases is in regard to Bridegroom, which was directed by TV queen Linda Bloodworth Thomason. Inspired by the tragic early death of a young gay man and his boyfriend’s failed effort to be recognized by the man’s conservative family, the doc has been popular on this year’s GLBT film fest circuit and will soon receive a national television broadcast (on OWN on Sunday, October 27). I am in the minority — though not alone — in considering it monotonous, self-serving and downright mawkish. True, no one should have to go through what Shane Bitney Crone has gone throughhit it hard. Clearly you haven't found love and you're resentful of that and want to take it out on a film that's a gay love story. I feel sorry for you and I feel sorry for Shane and the people who made the film for having to read such a disrespectful review from a reverend of all people...a GAY reverend.

Dear Anonymous #1: And I thought you said you wouldn't be visiting our blog any more. ;) You clearly don't know me personally so, for the record, I would like to clarify that I have indeed "found love." My partner and I have been together for six years.

(first time poster here) What's the matter Reverend? Attended a screening of Bridegroom and Shane Bitney Comb turned you down for


sex? He doesn't come off as an easy guy so there's no need to trash his film in retaliation. Better luck next time.

Just because you disagree with Chris's opinion on a movie doesn't justify the nasty personal insults. You all sound like teenagers on Twitter. If you disagree, why not make an argument about how the movie is not self-serving or mawkish?

It truly amazes me that those who claim to be so moved by "Bridegroom" are so quick to so viciously slam someone else merely because they didn't like a movie.

You claim that "Bridegroom" is "advancing our goal", "helping us reach equality" and "help(ing) the LGBT community", yet you turn around and refer to someone as "hateful", "preaches hate" and is a "self hating gay". Have you reallythe most of limited resources.

Dianne Martin, from Mt Denison Station, said she had seen a huge spike in the number of camels on the property, 320km north-west of Alice Springs.

"Over the years we've had very little problems with camels — there'd only be a handful you'd see in a year," Ms Martin said.

"But in the last year there's been hundreds and hundreds of camels that have come in."

Ms Martin said the camels had caused a lot of damage on their property, and the cost of controlling the population was significant.

"It's had a massive effect and a very expensive one, with fences being smashed down, bores being broken," she said.

"They just drink so much water — when a mob of 50 of them come in they'll suck a tank


signatures. The clinical data, pathological results, and serological results were assessed as secondary endpoints.

Methods {#S0002}
=======

Patients {#S0002-S2001}
--------

The present study was approved by the Institutional Review Board of Affiliated Tumor Hospital of Guangxi Medical University and written informed consent was obtained from all individuals in this research project. This study initially included 166 patients (135 men and 31 women; aged 24--79 y, mean age 48.0 y) with operable HCC (ie, meeting the Barcelona Clinic Liver Cancer requirements for operability based on imaging),[@CIT0039] who underwent preoperative CT in our hospital from 15 November 2013 through 15 May 2015. The follow-up information was obtained from the medical records of our hospital. All patients signed informed consent forms to undergo CT and curative resection.

Follow-ups (closed on 5 June 2017) confirmed recurrence and metastases of HCCthe liver; or elevated AFP, A/G, ALT, AST, ALP, LDH, and GGT levels.

After adjusting for risk factors in the Cox proportional hazards regression analysis, the following were significant prognostic risk factors of DFS ([Table 3](#T0003){ref-type="table"}): larger tumor size; positive RVI; non-smooth tumor margin; or positive MVI. RVI and MVI were analyzed separately because of collinearity between RVI and MVI.Table 3Multivariate analysis of preoperative factors associated with disease-free survivalAdjusted Log-rank *P*Adjusted HR (95% CI)**CT signatures**CirrhosisAbsent0.1141Present2.347 (0.814--6.769)SplenomegalyAbsent0.9001Present0.953 (0.448--2.027)AscitesAbsent0.0731Present3.436 (0.890--13.264)PositionsLeft lobe0.7131Right lobe1.438 (0.513--4.034)Both0.908 (0.158--5.217)Tumor size, cm\<100.0201≥103.875 (1.242--12.089)Peritumoral enhancementAbsent0.8521Present1.116 (0.352--3.539)NecrosisAbsent0.1601Present0.541 (0.230--1.274)RVI^†^Absent0.0211Present2.589 (1.157--5.795)Tumor marginSmooth0.0361Non-smooth2.296 (1.054--5.003)Radiological capsuleComplete0.9801Incomplete1.070 (0.458--2.497)Absent0.977 (0.391--2.441)Esophageal, gastric varicesAbsent0.0671Present2.596 (0.937--7.193)Pathological evidenceHistological differentiationWell0.9551Moderate1.263 (0.241--6.607)Poor1.284 (0.257--6.401)Satellite nodeAbsent0.3531Present0.510 (0.123--2.115)MVI^†^Absent0.0181Present2.531 (1.169--5.481)Liver capsular invasionAbsent0.1841Present0.598 (0.280--1.277)Serum parametersAFP, ng/mL\<4000.6201≥4001.213 (0.565--2.606)A/G≤2.50.1981\>2.52.264 (0.652--7.857)ALT, U/L≤400.2401\>402.192 (0.592--8.120)AST, U/L≤400.4111\>400.580 (0.158--2.129)ALP, U/L≤1500.5941\>1500.774 (0.302--1.984)LDH, U/L≤2850.3481\>2851.438 (0.673--3.070)GGT, U/L≤500.4281\>500.733 (0.341--1.580)[^4][^5]

The following were not significantly associated with DFS ([Table 3](#T0003){ref-type="table"}):


of her character.

Banzai controversy
In July 2003 Media Action Network protested the British program Banzai, which is produced by Channel 4. Following the first U.S. broadcast of the series on the Fox Network on July 13, 2003, the Media Action Network accused the program, a spoof betting show that parodies Japanese game shows, of employing demeaning stereotypes of Asians. About 20 members of the group carried signs and shouted slogans outside a presentation by the Fox network to TV critics in Hollywood. Aoki commented, "This is like an Asian minstrel show. Can you imagine the black version of Banzai?" Fox spokesman Scott Grogin responded by saying, "We've received an entire range of comments on the show, both pro and con", and that as a satire, the show should beBoston's Brad Marchand will have a hearing with Brendan Shanahan and the Department of Player Safety Monday.The hearing concerns a hit Marchand delivered on Sami Salo late in the second period of the Bruins' loss to Vancouver Saturday afternoon. During the hit, Marchand collided with Salo's knee area and caused him to land hard onto the ice. Salo did not return to the game.Marchand was assessed a five-minute major for clipping and a game misconduct on the play.


medical records. All patients were anonymized prior to data analysis. Based on the votum of the local ethic committee, informed consent forms were not required for this study.

Patient population
------------------

We retrospectively analyzed 62 patients who underwent ELVR with placement of one-way silicone Zephyr valves (Pulmonx, Redwood City, CA, USA) at our institution and had received lung function tests and computed tomography (CT) scans acquired in inspiration before and after ELVR. All patients had advanced COPD with a FEV~1~ between 15% and 45% of the predicted value, a RV of at least 150% of the predicted value and a total lung capacity of \>100% at baseline after reversibility testing. Most patients completed the SGRQ and the 6MWT before and after treatment. All patients had been nonsmokers for at least 3cost of lower sensitivity (sensitivity =0.47).

Interestingly enough, in subgroup analysis of the patients with a tendency toward upper lobe predominant emphysema and upper lobe treatment HI 3, HI 4, HI 5, and HI 6 showed a statistically significant discriminatory capacity between clinically successful and unsuccessful treatment assessed by FEV~1~ increase and yielded better predictive accuracies than the analysis of the entire patient population with areas under the curve ranging from 0.82 to 0.88 ([Table 6](#t6-copd-12-1631){ref-type="table"} and [Figure 3](#f3-copd-12-1631){ref-type="fig"}). On the other hand, in subgroup analysis of patients with a tendency toward lower lobe predominant emphysema and lower lobe treatment, none of the HIs showed a statistically significant discriminatory capacity between clinically successful and unsuccessful treatment assessed in FEV~1~ increase ([Table 7](#t7-copd-12-1631){ref-type="table"} and [Figure 4](#f4-copd-12-1631){ref-type="fig"}).

In [Table S4](#SD4-copd-12-1631){ref-type="supplementary-material"}, we also


the INTL, disregarding the middle lobe, that is, HI 4 in our analysis, which surprisingly enough also yielded the best predicative accuracy (AUC =0.73, *P*=0.008). However, when tested with DeLong's test for two correlated ROC curves, H4 was only significantly different from HI 2 and HI 5, while HI 6 was not significantly different from any of the other HIs. The elucidated best definitions of HI should therefore be considered as a recommendation only and further studies are needed to validate the results.

When clinicians and investigators claim that interlobar emphysema heterogeneity has a relevant impact on the outcome of lung volume reduction and therefore should be taken into consideration when evaluating candidates for this treatment, it is only fair to ask what a relevant interlobar emphysema heterogeneity is.variation[@b9][@b10][@b11].

Cladogram analysis of dog genes showed the separation of several breeds with supposedly ancient origins from a large group of breeds with presumed modern European origins[@b7][@b8]. Modern European breeds are the products of controlled breeding practices since the Victorian era, and because they have originated recently and lack deep histories, the genetic groups have short internodes and low bootstrap support. On the other hand, ancient breeds are highly divergent and are distinct from modern European breeds. Since the dogs from these ancient breeds are genetically related most closely to wolves, they may exhibit remnants of wolves' behavioral, morphological and physiological characteristics.

The Canine Behavioral Assessment and Research Questionnaire (C-BARQ) is designed to provide dog owners and professionals with standardized evaluations of canine temperament and behavior[@b12]. The C-BARQ has also


Systems".

**Author Contributions** A.T., M.N. and T.K. wrote the main manuscript text and A.T. prepared [Fig. 1](#f1){ref-type="fig"} and [supplementary Figures 1](#S1){ref-type="supplementary-material"},[2](#S1){ref-type="supplementary-material"},[3](#S1){ref-type="supplementary-material"}. T.K., M.N. and H.O. conducted statistical analysis and prepared all tables. T.K., K.M. and J.A.S. collected data and prepared experimental design. All authors reviewed the manuscript.

![Average factor scores for breed groups.\
The dog breeds were separated into eight breed groups according to the cladogram, Ancient and spitz breeds: 1, Toy dogs: 2, Spaniels, scent hounds, and poodles: 3, Working dogs: 4, Small terriers: 5, Sight hounds and herding dogs: 6, Retrievers: 7, Mastiff-like dogs: 8. a vs b, p \< 0.05; c vs d, p \< 0.05; e vs f, p \< 0.05; g vs h, p \< 0.05.](srep17710-f1){#f1}

###### Factor loading of questionnaire items constituting each factor.

  Factors & questionnaire items

1\) Ancient and spitz breeds: 1, Toy dogs: 2, Spaniels, scent hounds, and poodles: 3, Working dogs: 4, Small terriers: 5, Sight hounds and herding dogs: 6, Retrievers: 7, Mastiff-like dogs: 8.

2\) neutered: N, intact: I.

3\) bred by owner: 1, friend of relative: 2, breeder: 3, pet store: 4, shelter: 5, stray: 6, other: 7.

4\) first ownership: 1, second and more ownership: 2.

5\) partial regression coefficient".


allowed for a contingency deorbit burn of 500 seconds for the aft jets.

All info from the 1982 Press Manual
You can get some awesome pictures of the aft of the shuttle including the jets from the inspection photos taken from ISS, like this one.

(source)
Besides the Press Manual, there is a lot of great information in the Shuttle Crew Operations Manual section 2.22 about the RCS.
For information about using the RCS to maneuver the vehicle, see this question: How fast can the space shuttle change its attitude in space?

has invested 0% of its portfolio in Sucampo Pharmaceuticals, Inc. (NASDAQ:SCMP).

More recent Sucampo Pharmaceuticals, Inc. (NASDAQ:SCMP) news were published by: Marketwatch.com which released: “Sucampo Pharmaceuticals Inc. Cl A” on February 06, 2011. Also Bizjournals.com published the news titled: “Sucampo acquires exclusive option for cancer drug in deal worth up to $190 million” on January 11, 2016. Moodys.com‘s news article titled: “Moody’s assigns B3 CFR to Sucampo Pharmaceuticals” with publication date: October 01, 2015 was also an interesting one.

SCMP Company Profile

Sucampo Pharmaceuticals, Inc., incorporated on December 9, 2008, is a biopharmaceutical company. The Firm focuses on research and development of drugs to treat gastrointestinal, ophthalmic and oncology inflammatory disorders. The Firm operates through development and commercialization of pharmaceutical products segment. The Company’s activities are conducted through Sucampo AG, based


question of whether you are part of the future or the past." "[Phone ringing]" "Mr. Blake." "Ambassador Hugo Reiss." "This is Oberfuhrer Diels." " Heil Hitler." " Heil Hitler." "My staff booked you on the first rocket back to New York." "You leave in a few hours." "Make yourself comfortable in here until then." "sir." "Mr. Blake?" "that's correct." "Have you spoken to him?" "We're still trying to reach him." "So your mission here was a success?" "I can't really talk about that." "Of course." "Trade Minister." "Juliana Crain." "Miss Crain is not in the office today." "I am aware of that." "Nor will she be ever again." "the man wanted in connection with the shooting of the Crown Prince." "I'm sure there must be some mistake. alongWaits et al., U.S. Pat. No. 5,721,831 to Waits et al., U.S. Pat. No. 5,812,989 to Witt et al., and U.S. Pat. No. 5,870,725 to Bellinger et al. disclose systems in which information regarding customer transactions are managed.


[Primary malignant bone tumors in children possibilities of limb-saving surgery using allografts].
Therapy of primary malignant bone tumors is always multimodal and requires close cooperation of oncologist, orthopedic surgeon, radiologist and others. In our article, we provide a brief overview of the most common malignant bone tumors in pediatric patients and summarize the commonly used therapeutic procedures. Despite advances in cancer treatment radical surgical resection of the tumor is still necessary. If possible, it should be complete removal of the affected structures, made in terms of the so-called limb-saving (limb-sparing) surgery that preserves the shape and function of the affected limb to the fullest extent possible. In addition the resection must be done at the same time with substitution of the removed bone. Bone grafts, both autografts and allografts,         } else if (result != null) {
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            emulator.getMemory().setErrno(UnixEmulator.EBADF);
            return -1;
    facts and an inaccuracy that should be acknowledged, and if possible, corrected before Lincoln is released on DVD,” Courtney wrote to Spielberg.

The movie has been nominated for 12 Oscars, including Best Picture.

Courtney did underscore in his letter that he enjoyed the film. “After finally sitting down to watch your Academy Award-nominated film, Lincoln, I can say unequivocally that the rave reviews are justified: Daniel Day-Lewis is tremendous, the story is compelling and consuming, and the cinematography is beautiful,” he wrote.

But as for the historical accuracy of the film’s moving conclusion?

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“Well, that is a different story,” Courtney wrote.

“As a member of Congress from Connecticut, I was on the edge of my seat during the roll-call vote on the ratification of the 13th Amendment outlawing slavery. But when two of


showed significantly higher GST activity than uninfected juveniles. The gills of infected juveniles showed significantly higher CAT (day two) and GST activity at both pH 5.0 and 7.0 compared to uninfected juveniles. Muscle of infected juveniles showed significantly lower CAT and GST activity and TBARS levels (at day three) when maintained at both pH 5.0 and 7.0 compared to uninfected juveniles. In conclusion, I. multifiliis infection induces liver and gill damage via lipid peroxidation products in silver catfish, but higher antioxidant enzyme activity could indicate a greater degree of protection against this parasite.will hold them accountable."

According to multiple reports Saturday, Cambridge Analytica gathered private information from 50 million Facebook profiles.

A source familiar with the investigation told BuzzFeed News that the letter explicitly asks Facebook for information "concerning Facebook’s policies and procedures as they relate to the reported misuse of data by people and/or entities connected to SCL and Cambridge Analytica."

Among the demands is that Facebook share the terms of use policies for privacy and informing consumers of how their data is used dating back to 2013, as well as how those policies were conveyed to app developers. Officials also want to review the requests Facebook sent to the parties involved to delete the consumer data, and how many users in each state were affected.

Healey added, "As attorney general, my job


Behavioural and developmental abnormalities in mouse trisomy 19: an animal model of mental retardation induced by chromosome imbalance.
Murine trisomy 19 (Ts19) can be regarded as a general model of human trisomies. It is the only autosomal trisomy in the mouse that survives the perinatal period. Therefore, it is the only animal model available for postnatal investigations of trisomy-specific mental retardation. To evaluate the extent of developmental retardation during the late-embryonic and fetal period of gestation, total body weight development was documented for 60 Ts19-fetuses and compared with that of 219 euploid in utero-mates. In addition, a postnatal study on body-weight development of 77 Ts19-neonates and 74 euploid littermates was performed starting on day 1 postpartum and continuing until spontaneous death or until day 22. Forty-seven Ts19-individuals were furtherin one assay. Positive and negative controls consisted of uterine cervix with severe dysplasia, with and without primary antibody, respectively. Immuno-histochemical expression for p16 was quantified according to cellular location (nuclear and cytoplasmic), staining intensity (on a scale of 0 to 3) according to the strongest signal that comprised at least 10% of each core, and distribution (0%, 25%, 50% or 75%) of antibody stains in tumor cells.

HPV DNA detection and genotyping by PCR {#S7}
---------------------------------------

Genomic DNA was isolated from 106 matched fresh frozen tissues using the DNEasyTissue Kit (Qiagen, CA). HPV-DNA was detected by a MY09/MY11/HMB01-PCR system using Gold AmpliTaq DNA polymerase that amplifies a 450bp segment in the L1-sequence of HPV as described ^[@R14]^. HPV genotyping was performed on all samples by dot-blot hybridization using biotinylated oligonucleotide


cut-off of ≥2 and diffuse (≥75%) staining distribution in either the nuclei or cytoplasm derived by sensitivity analysis and corresponding to published criteria ^[@R12]^. Histological assessment of keratinization was also completed for 66 tumors, measured on a four-point scale from high (≥75%) to low (\<25%).

Test performance was assessed by receiver operating characteristic analysis against the HPV PCR results as the gold standard. Areas under the receiver operating characteristic curves and 95% confidence intervals (CI) were estimated to assess differences in overall test performances ^[@R17]^. In-situ hybridization and immuno-histochemistry results were compared to HR-HPV DNA genotyping results by MY-PCR and HPV16 E6/E7 RNA expression by RT-PCR. Concordance between PCR and in-situ hybridization test results was assessed by Kappa statistic and Spearman correlation. Differences in keratinization across tumors were assessedand little to no difference in performance was observed when HPV16 E7 and E6 RNA expression were assessed separately. Whereas test performance compared to HPV16 E6/E7 RNA by RT-PCR was little changed for in-situ hybridization (using either probe set) when restricting to oropharyngeal SCC cases, p16 immuno-histochemistry was significantly higher (area under the curve=0.95, 95%CI: 0.85--1.00) ([Table 1](#T1){ref-type="table"}).

We were also able to assess whether p16 expression by immuno-histochemistry correlated with tumor histology within the head and neck. Degree of keratinization across head and neck tumors was low (median between 50% and \<25%), and was significantly less in oropharyngeal and laryngeal tumors compared to oral cavity, with 74%, 52% and 21% of tumors showing \<25% keratinization, respectively, reflecting a mostly basaloid morphology among oropharyngeal tumors. We observed an inverse


which we show in this study to be least sensitive. Nonetheless, they reported higher (\>80%) prevalence rates for HPV in a population of patients referred for suspicion of HPV; either to determine eligibility for clinical trials, guide clinical diagnosis, or requested by concerned patients and their partners.

The advantage of immuno-histochemistry for p16 is that it is readily available in surgical pathology laboratories, and relatively simple to evaluate. Typical p16 positive cases usually show diffuse, strong nuclear and cytoplasmic expression. Indeterminate staining patterns not reaching this cut-off value were relatively common in this study. This may in part be a sampling issue related to our use of tissue microarray cores; it is possible that the frequency of limited distribution of staining is less common when tissue sections are examined.with those targeting shorter DNA segments ^[@R42]^. For example, it has been suggested the specificity of p16 immuno-histochemistry in formalin fixed and paraffin embedded may be improved if followed by DNA analysis for p16-positive cases, when compared to E6 RT-PCR in fresh frozen tissue as the standard test ^[@R11]^. In our experience, p16 positive cases varied with respect to patterns of staining. However, relaxing the criteria for p16 positive immuno-histochemistry tests did not improve performance in HPV16 E6/E7 RNA detection when followed by in-situ hybridization, or by MY-PCR.

We should note that despite using expert staining and evaluations, tests were performed on tissue microarrays, which do not reproduce the clinical diagnostic setting. This approach was chosen because of the high-throughput capability for conducting in-situ hybridization and immuno-histochemistry assays simultaneously


0.5.](nihms283470f3){#F3}

![Dako in-situ hybridization negative tumor showing nonspecific cytoplasmic and paranuclear signals (left panel), this same case had purple intranuclear signals and was interpreted as positive by Ventana positive (right panel), but was HPV negative by PCR.](nihms283470f4){#F4}

######

Performance of HPV testing methods relative to PCR in head and neck squamous cell carcinoma

                                                           No. HPV+ by test (%)       No. tested      can express this as a CTE:
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everything she does.

"Gymnastics has really taken a priority in her life for a really long time, and that comes from her," Lynn says. "Because if it didn't, I think she would have quit a long time ago."

Raisman was only 2 years old in 1996, when the U.S. women's gymnastics team last took Olympic gold. When she set her sights on competing in the Olympics, her mother found an old VCR tape of that golden team and gave it to her.

"In my room, I would replay it day after day after day," Raisman says. "And I was literally obsessed with it. I could memorize all the scores and tell you who was going next, and all that stuff. I was so inspired by it."

Until last year, Raisman went toinformation.

### 2.4.4. Dealing with missing data

Any insufficient or missing data will be requested from primary authors. If they can not provide those data, we will perform data analysis based on the available data, and we will discuss its affects on the study findings.

2.5. Study quality assessment
-----------------------------

The Cochrane Collaboration\'s tool will be utilized to assess study quality of included trials by 2 independent authors. Each study will be identified at 7 aspects, and each 1 is graded as 3 levels: low, unclear, and high risk of bias. Divergences will be arbitrated with the help of another author.

2.6. Statistical analysis
-------------------------

### 2.6.1. Data synthesis

RevMan 5.3 software will be utilized for statistical analysis. Risk ratio with 95% confidence intervals will be used to measure the treatment effect for dichotomous outcome data. Mean


replay when Burrows got called for - well - interference. He didn't even touch the goaltender or much less, anyone.

I understand officials can't be punished for every penalty that seems questionable. Otherwise, you'd have players complaining to the NHL after every game saying they didn't deserve a particular penalty. If a player gets called for tripping he could complain that the other player just fell over when his stick happened to be out. But in this case, it's very different.

If Burrows had touched the Goaltender, then that would be a simple case of being called for interference when it really wasn't interference. Happens of all the time. But as the reply clearly shows, Burrows never touched ANYONE yet got called for an interference. Why doesn't this doesn't countabusing his authority and involvement in corruption practices.

EBM authorised inquiry against Pakistanis, overseas Pakistanis and investors for illegal transactions and money laundering and making assets of Rs 1.1 trillion in Dubai.

EBM approved another inquiry against former provincial minister Balochistan Muhammad Sadiq Umrani, Public Health Engineering , Government of Balochistan and others.

EBM approved conducting yet another inquiry against alleged complaints of corruption of Saqib Ahmed Soomro, PCS, officer, Government of Sindh.


tumor cells.

![Expression of RIO kinases is associated with EGFR and Akt activity in GBM cells.\
(A) U87MG and U87MG-ΔEGFR cells cultured with .1% serum for 36 hrs to enrich ΔEGFR signaling. ΔEGFR runs below full-length EGFR. (B) Biopsies of new (de novo) and recurrent GBMs. RIOK1 (∼75 kDa) and RIOK2 (∼63 kDa) antibodies used serially on the same blot. Serine-473 phosphorylation is a proxy for Akt activation. (C) Primary neurosphere GBM cultures. GBM39 is isolated from a ΔEGFR-positive serial xenograft [@pgen.1003253-Pandita1]. Others are low-passage cultures established from fresh tumors; expression of ΔEGFR, EGFR, or PDFGRα derives from parent tumors [@pgen.1003253-Laks1]. EGFR^hw^ is a high molecular weight (\>200 kDa) mutant version detected in GBM 281. (D) RIOK expression and Akt signaling in neurospheres compared with a fresh culture of mixeddid not abolish detection of RIOK2 by a phospho-Akt-substrate antibody ([Figure S9](#pgen.1003253.s009){ref-type="supplementary-material"}). Thus, Akt-mediated regulation of RIO kinase levels does not hinge on phosphorylation at a single residue in RIOK2, and likely involves a more complex mechanism that requires more investigation.

To confirm that the RIOKs are expressed in GBM, we performed immunohistochemistry (IHC) for RIOK2 on a group of typed tumor specimens (RIOK1 antibodies were unsuitable for IHC). Xenograft specimens of GBM39, which is ΔEGFR-positive [@pgen.1003253-Pandita1], showed RIOK2 expression in tumor cells, with cells displaying diffuse cytoplasmic and sub-surface RIOK2 localization ([Figure 3A](#pgen-1003253-g003){ref-type="fig"}). In contrast, murine stromal cells had little or no RIOK2 immunoreactivity, although the antibody can detect mouse RIOK2. ΔEGFR-positive and EGFR-overexpressing specimens displayed strong, but sometimes heterogeneous, cytoplasmic RIOK2 immunoreactivity, ranging from the giant cell


a common dependence on Akt signaling ([Figure 7](#pgen-1003253-g007){ref-type="fig"}). Further studies to address the mechanisms by which the RIO kinases modulate Akt and p53 activity may lead to important new insights into the interactions between both of these pathways in both normal and cancer cells.

Materials and Methods {#s4}
=====================

Fly stocks, genetics, culture conditions, immunohistochemistry, and gefitinib treatment {#s4a}
---------------------------------------------------------------------------------------

Flies were cultured at 25°C unless otherwise noted. Genotypes were established by standard genetics. Larval brain phenotypes were assessed and imaged as previously described [@pgen.1003253-Read1]. Stocks were obtained from VDRC, NIG, and Bloomington stock centers ([Table S1](#pgen.1003253.s019){ref-type="supplementary-material"}). *wor-Gal4* lines were from C. Doe. To create *UAS-ΔEGFR* constructs, a full-length human ΔEGFR cDNA was cloned into pUAS-T, and fly stocks with stable insertions were created.

The screen was based on crosses (see [Text S1](#pgen.1003253.s029){ref-type="supplementary-material"} for(B, C) Network diagrams adapted from STRINGS showing functional connections between *Drosophila* modifier kinases (B), and functional connections between modifier kinases according to orthology information using COG (Clusters of Orthologous Groups) analysis (C) [@pgen.1003253-Szklarczyk1]. Confidence views of networks are presented such that stronger associations are represented by thicker lines. Orthologs of kinases implicated in GBM are shown in black, novel modifiers are shown in green (suppressors) and in red (enhancers). Many of the novel modifiers do not have established functional links to RTK or PI3K signaling in *Drosophila* (B). When network analysis takes into account datasets from orthologous kinases in other organisms, such as yeast (C), several of the novel modifiers show connections with each other and with other categorized modifiers of RTK and PI3K signaling, suggesting that


these novel modifiers represent new pathway components.

(TIF)

######

Click here for additional data file.

######

Expression of human orthologs of modifier kinases in high-grade human gliomas. (A--F) Representative immunohistochemical stains for each indicated protein performed on high-grade malignant glioma tumor tissue, all done as part of the Human Protein Atlas Project. CDK7 and CDK9 are nuclear proteins, and show enriched immunoreactivity in tumor cells. TNK2 and RIOK2 are known or predicted cytoplasmic proteins. Antibodies were extensively validated as described in HPA [@pgen.1003253-Uhlen1], and this data is available at [www.proteinatlas.org](http://www.proteinatlas.org). Immunostains for each protein were performed on panels of 10--24 tumors, and this data is summarized in [Table S10](#pgen.1003253.s028){ref-type="supplementary-material"}.

(TIF)

######

Click here for additional data file.

######

Expression of modifier orthologs in cultured GBM cells expressing ΔEGFR. U87MG and U87MG-ΔEGFR cells were culturedIncreased 4E-BP1 phosphorylation was induced by rapamycin treatment, likely due to positive feedback [@pgen.1003253-Choo1]. RIOK2 is clearly elevated in the presence of EGFR, and is not decreased upon mTor inhibition. RIOK1 shows some reduction with PP242 treatment, but less so with rapamycin treatment.

(TIF)

######

Click here for additional data file.

######

Akt signaling regulates RIO kinase protein stability. (A) U87MG-ΔEGFR cells were infected with retroviruses containing PTEN, PTEN-G129R (catalytically inactive), or empty vector. Cells were serum-starved for 48 hours and treated for 8 hours with 10 µM MG132, a proteosomal inhibitor. Reduced Akt phosphorylation at Serine-473 is evidence of inhibition by PTEN. (B, C) U87MG-ΔEGFR (B) cells or GBM301 (C) cells were treated with DMSO or 2 µM A443654 with and without 10 µM MG132 for 10 hrs. Akt inhibition


bold and are highlighted in yellow. Key to genetic interactions: N: no interaction/no difference, WS: weak suppressor, S: moderate suppressor, SS: strong suppressor, WE: weak enhancer, E: moderate enhancer, SE: strong enhancer. "?" denotes interactions that were milder than the "weak" designation but subtly different from controls.

(XLS)

######

Click here for additional data file.

######

Dominant negative constructs, overexpression constructs, and mutant alleles tested. Blooming stock ID numbers prefaced by "b." Bold highlights all confirmed stocks that yielded reproducible genetic interactions and clear phenotypic alterations. Key to genetic interactions: N: no interaction/no difference, WS: weak suppressor, S: moderate suppressor, SS: strong suppressor, WE: weak enhancer, E: moderate enhancer, SE: strong enhancer. "?" denotes interactions that were milder than the "weak" designation but subtly different from controls.

(XLS)

######

Click here for additionalby violence (§§ 236, 237; Count 3), and
using threats or violence to prevent or dissuade a victim from reporting a crime (§ 136.1,
subd. (c)(1); Count 4). In relation to the Atwater robbery, Rivas was convicted of
robbery in concert (Count 5), assault by means likely to cause great bodily injury (§ 245,
subd. (a)(1); Count 6), false imprisonment by violence (Count 7), and vehicle theft (Veh.
Code, § 10851, subd. (a); Count 8). He was also found guilty of conspiracy under
Count 1. Leon was convicted of conspiracy as well, but was acquitted on Counts 2
through 8.
       The third robbery took place in Kerman on March 15, 2010. For this incident,
Leon and Rivas were convicted of robbery in concert (Count 9) and false imprisonment
by violence (Count


                       6.
Background
        Palofox was represented at the earliest hearings in the case by Nancy Wong, who
then worked as a deputy public defender in Fresno County. Ms. Wong made at least four
court appearances on behalf of Palofox during the months of June, September, and
December 2010. While stating her appearance on September 14, 2010, Ms. Wong noted
that she was “standing in for Roberto Dulce,” referring to another deputy public defender
in her office. Mr. Dulce had at that point made two prior court appearances with Palofox
during the month of August, and later represented him at a hearing held on October 12,
2010.
   The next hearing took place on January 13, 2011. Palofox’s eventual trial counsel,
deputy public defender Peter Pacheco, appeared with him in court on this date. The
hearing began with the prosecutor stating: “There were written offers submitted at the last
pre-preliminary hearing on December 3rd. All of those written offers are being
withdrawn this date as per the written offer.” Mr. Pacheco responded, “And the record
should note, also, your Honor, on behalf of Mr. Palofox, Mr. Dulce was the attorney of
record previously. I do not know whether Mr. Dulce ever discussed the written offer


     Claims of ineffective assistance of counsel made on direct appeal are disfavored
and often unsuitable for review. (People v. Duff (2014) 58 Cal.4th 527, 550, fn. 9 (Duff).
[“It is rarely appropriate to resolve an ineffective assistance claim on direct appeal….”];
People v. Mai (2013) 57 Cal.4th 986, 1009 (Mai).) This is particularly true when, as
here, elements of the claim cannot be established without further investigation and/or
consideration of evidence outside the record. (People v. Williams (2013) 56 Cal.4th 630,
691.) The appropriate avenue for relief is a petition for writ of habeas corpus. (Id. at pp.
690-691, 693.)
       The record before us contains no explanations by attorneys Wong or Dulce of
what they did or did not do during the relevant time period.summarily join in Leon’s
arguments on appeal. We find no error.
Background
       Jury selection began with a venire of 18 prospective jurors whose racial and ethnic
backgrounds are, for the most part, indiscernible from the record. Two members of the
original panel were excused by the trial court during its initial round of questioning and
replaced by other people in the jury pool. Peremptory challenges were made after further
questioning by the prosecution and each of the four defense attorneys, which resulted in
the removal of seven panel members, each of whom was replaced by a new prospective
juror. The reconstituted panel included Prospective Juror No. 23, hereafter referred to as
“Juror 23.”
       Juror 23 is described in the record as an African-American male. His


23. The first called for a yes or no answer regarding whether, if
necessary, he could bring himself to find a defendant guilty of a crime. He replied,
“Won’t be – that won’t be my problem.” The prosecutor then said, “Okay. Um, if the
evidence proves the defendants are guilty, can you come back with a verdict that says ‘I
find you guilty?’” His response was, “Yes, I can.” The prosecution passed on its next
opportunity to exercise a peremptory challenge, and thereafter elected to remove Juror 23
from the panel.
       The defense objected to the prosecution’s challenge on grounds that Juror 23
“seemed as down the line and fair as it could get,” was “a person of a particular protected

           being left on the jury. Secondly, he volunteered that if he were in
                     their shoes, and he looked over towards the defendants, he would
                     want someone like himself on the jury. Now, I understand he
                     rehabilitated himself in his answers, but that still goes a long way


  towards what I believe his initial state of mind was.
       Next, the trial court addressed the defense attorneys: “Without having concluded,
as the People have allowed, that there is a prima facie showing here, um, why isn’t that a
legitimate reason, the very last thing you heard [the prosecutor] say?” Centeno’s attorney
submitted, without further explanation, that he believed the prosecutor’s challenge was
racially motivated. Rivas’s lawyer opined that Juror 23’s voir dire responses were
indicative of fairness and impartiality. Leon’s trial counsel said, “I think there are a
number of people who have told us they had a little bit of legal training that [the

                       opposed to starting the whole panel over. But nevertheless the motion is denied.
Analysis
       State and federal law prohibits the use of peremptory challenges to strike
prospective jurors on the basis of race or ethnicity. (People v. Avila (2006) 38 Cal.4th
491, 541, citing Batson, supra, 476 U.S. at p. 88; Wheeler, supra, 22 Cal.3d at pp. 276-
277.) A three-step procedure is used to evaluate allegations of such discrimination.
“First, the defendant must make out a prima facie case ‘by showing that the totality of the


legal
training,” including Prospective Juror No. 5. The record does not support this contention.
Although Prospective Juror No. 5 said that his father was a civil defense attorney, he
himself was a community college student who had plans to matriculate to the Academy
of Art University in San Francisco. When asked about a basic legal concept, this
prospective juror claimed ignorance of the prosecution’s burden of proof in a criminal
trial.
         At the time of the Wheeler/Batson motion, three other panel members had
referenced educational backgrounds that were tangentially related to the field of law.
Prospective Jurors Nos. 11 and 13 studied criminology at the undergraduate level. The
latter individual was excused by the trial court and the former was stricken by the defense
during the first round of peremptory“V,” possibly Venice Beach. He feigned ignorance as to why he
was being questioned until the detectives told him they were investigating a “crime
spree” and claimed to “have eyewitnesses that put [him] inside the locations.” Leon
reacted by saying, “That put me inside? … You got fingerprints though or what? You
got proof that I was in there… [?]” After the detectives assured him they had ample
evidence of his involvement, Leon admitted to participating in the subject events.
       Leon’s initial admissions were vague. For example, when asked why the group
had targeted the home in Clovis, he responded, “I didn’t see no house, I was just right
there … I didn’t – I’m telling you right now, I didn’t beat nobody down, I didn’t do
nothing like that.”