- 5808. Which is smaller: b or s?
b
Let u = 11780 + -11779. Which is smaller: u or 51/80?
51/80
Let g(u) = -u**3 + 5*u**2 + 5*u + 5. Let d be g(6). Let i be ((-84)/1)/(0 - (-25)/(-60)). Let j = i + -73574/365. Is j bigger than d?
True
Let w = -20160 - -20369. Is 210 not equal to w?
True
Let d = 1/1043780 + -5669812977/17744260. Is d greater than or equal to -320?
True
Suppose -15*q - 200 = -20*q - 3*f, -205 = -5*q - 2*f. Suppose -3*x = u - 3 + 20, -q = 3*u + x. Let p = -34 - -21. Does u = p?
False
Let q = 47546/3 + -15849. Which is bigger: 20330 or q?
20330
Let i = -6863 + 10340. Is i != 2?
True
Letq be (-7)/60 - 82/(-1230). Which is smaller: q or -3/16?
-3/16
Let x(u) = 16*u + 39. Let y be x(-15). Suppose -4*w - 818 = 3*s - s, 4*w + 4*s = -828. Which is smaller: w or y?
w
Suppose 4*d = -3*q + 336, -4*d = 4*q - 31 - 301. Let s = d + -87. Which is smaller: s or 2/209?
s
Let k = -1.8 - 5.2. Let h(w) = -w**3 - w**2 - 3*w - 6. Let q be h(-2). Let f be 39*(-2)/(-21) - q. Which is greater: f or k?
f
Let q = -146 + 147. Which is smaller: q or -58/181?
-58/181
Let v(p) = -p**2 - 21*p + 47. Let n be v(-26). Let q = 61 + n. Do -27 and q have different


many patients are being exposed to multiple doses of radiation which can lead to high cumulative dose, therefore, it is necessary to take a more cautious approach regarding the patient's absorbed dosage \[[@ref3]\].

Myocardial Perfusion Imaging (MPI) is one of the most common techniques which is used in the field of nuclear medicine. Technetium-99m compounds are used to image heart muscle perfusion and emits photons with energies 140 KeV \[[@ref4]\] It is usually performed by Technetium-99m methoxy isobutyl isonitrile (99mTc-MIBI), in two separate stress and rest phases \[[@ref6]\]. The bio-distribution of 99mTc-MIBI is characterized by a rapid blood clearance and consequently early myocardial uptake. The initial intense hepatic activity is cleared into the gall bladder after 1h and the best target to non-target ratio is observed at 60-90 minadverse effects of low-dose radiation exposure for patients.

According to analyzed data, the mean value of statistical variables of TP, Alb, Glo, AST, ALT, ALP, D.Bili, T.Bili, SI, TIBC and A/G Ratio were statistically significant (P\< 0.05). While the injection of 99mTc MIBI showed no statistical significant changes on the CBC level (P value \> 0.05). Sony et al. reported that by increasing the radiation dose in the animal model P decreased \[[@ref17]\]. These data are consistent with data obtained in our study. Nwozo et al. showed that irradiation of 6Gy y-radiation to male Wistar rats caused an increase in serum concentrations levels of ALT and AST \[[@ref18]\]. In addition, Li et al. proved that the use of ALT was a significant predictive factors for radiation-induced liver injury \[[@ref19]\].


 She was aware that she had the right to file a grievance over this breach of faith and potentially to obtain full reinstatement from the City Civil Service Commission.  Neither then nor later, however, did she ever pursue a grievance concerning the settlement agreement.3   Instead, she filed this lawsuit in December 1984.

13
The availability of a grievance and hearing procedure which would have enabled Dr. Rathjen to contest the circumstances of her voluntary demotion or her unsuccessful settlement agreement renders this a different case from our constructive discharge cases.  Those cases rested on the premise that once an employee has voluntarily resigned, no procedural remedy is available from his former employer.  Indeed, in Fowler, 799 F.2d at 979, and Findeisen, 749 F.2d atGlans hyperemia after penile revascularization: a late complication following alpha-1-receptor blockade for benign prostatic hyperplasia.
Surgical revascularization of the penile vessels is one treatment choice for patients with vasculogenic impotence. Hyperemia of the glans is a rare but severe complication which usually occurs early. We report a patient who developed this complication more than 3.5 years after surgery following onset of medical treatment of benign prostatic hyperplasia with a vasodilating alpha 1-receptor blocker.


electronic features of this collection capture specific characteristics of grassroots activism in the South during a time of intense racial and socioeconomic strife.

Family living in one of several “tent cities” founded to house those who were evicted after registering to vote. Circa 1960. Photograph: Preservation and Special Collections Department, University Library, University of Memphis.

My work with the Hooks Institute began at a critical juncture in my life. In 2015, social media and the news were rife with examples of police brutality and other injustices against marginalized groups. I had become overwhelmed with a sense of powerlessness in response to the wide circulation of audio and video footage depicting graphic violations of civil rights—especially that involving deadly interactions that occurred between law enforcement and black women, men, and children.in furthering civil rights and social justice have taken place. Since I began working with the Hooks Institute, the turbulent social and political landscape of which I was previously afraid has only intensified as we have struggled to engage with one another to discuss issues, such as race relations, gender equality, immigration, gender identity, environmental justice, and many more. Despite this, I—and I hope many in the nation—believe it is imperative to work actively towards a renewed, spirited and tenacious sense of unity to effect meaningful, positive change for each and every one of us. My exploration of the civil rights movement in Fayette County allowed me to situate myself and today’s social and institutional struggles within a legacy of unified and effective resistance to injustice in our


is 56 minutes before 12:51 AM?
11:55 PM
What is 514 minutes after 9:50 AM?
6:24 PM
How many minutes are there between 6:02 AM and 4:43 PM?
641
What is 616 minutes after 2:41 AM?
12:57 PM
What is 371 minutes before 5:39 AM?
11:28 PM
How many minutes are there between 11:54 PM and 7:59 AM?
485
What is 126 minutes before 11:50 AM?
9:44 AM
What is 597 minutes bRubenstein Family Giant Panda Habitat at the Smithsonian National Zoological Park January 6, 2014 in Washington, DC. Born August 23, 2013, and weighing nearly 17 pounds, Bao Bao will make her public debut at the zoo on January 18. (Photo by Chip Somodevilla/Getty Images)

Bao Bao Panda CubBao Bao, the Giant Panda cub, is seen by the media for the first time Jan. 6, 2014. (Photo by Chip Somodevilla/Getty Images)

Bao Bao Panda CubBao Bao, the Giant Panda cub, is seen by the media for the first time Jan. 6, 2014. (Photo credit: PAUL J. RICHARDS/AFP/Getty Images)

Bao Bao Panda CubBao Bao, the Giant Panda cub, is seen by the media for the first time Jan. 6, 2014. (Photo by Chip Somodevilla/Getty Images)

Bao Bao Panda CubBao Bao, the Giant Panda cub,


is seen by the media for the first time Jan. 6, 2014. (Photo by Chip Somodevilla/Getty Images)

Bao Bao Panda Cub

WASHINGTON, DC - JANUARY 06: Giant panda bear cub Bao Bao (L) and her mother Mei Xiang move around inside the David M. Rubenstein Family Giant Panda Habitat at the Smithsonian National Zoological Park January 6, 2014 in Washington, DC. Born August 23, 2013, and weighing nearly 17 pounds, Bao Bao will make her public debut at the zoo on January 18. (Photo by Chip Somodevilla/Getty Images)

Giant panda bear cub Bao Bao (L) and her mother Mei Xiang move around inside the David M. Rubenstein Family Giant Panda Habitat at the Smithsonian National Zoological Park January 6, 2014 in Washington, DC. Born August 23, 2013, and weighing nearly 17pounds, Bao Bao will make her public debut at the zoo on January 18. (Photo by Chip Somodevilla/Getty Images)

Panda Cub Bao Bao Makes Her Debut At Washington's National Zoo

WASHINGTON, DC - JANUARY 06: Giant panda bear cub Bao Bao (L) and her mother Mei Xiang move around inside the David M. Rubenstein Family Giant Panda Habitat at the Smithsonian National Zoological Park January 6, 2014 in Washington, DC. Born August 23, 2013, and weighing nearly 17 pounds, Bao Bao will make her public debut at the zoo on January 18. (Photo by Chip Somodevilla/Getty Images)

Giant panda bear cub Bao Bao (L) and her mother Mei Xiang move around inside the David M. Rubenstein Family Giant Panda Habitat at the Smithsonian National Zoological Park January 6, 2014 in Washington,


Additional Links

New hires and promotions

Banking

Peter J. McLaughlin has been promoted to assistant vice president at BB&T. He is a mortgage adviser in the bank's Goose Creek branch. He has a bachelor's degree in business from Edinboro University.

Construction

Robin Crider has been named site manager for J. Musselman Construction. He has 21 years experience in commercial construction. Previously, he was with Ruscon Construction and Mashburn Construction.

Health care

Dr. Edward C. O'Bryan III joined Nason Medical Center as an urgent care and emergency care physician. Previously, he was an attending physician in emergency medicine at the VA Medical Center, and is a clinical instructor at the Medical University of South Carolina. He has a medical degree from MUSC and is board-certified in internal medicine.

Hotel

Taylor Ruby has been promoted to executive privilege programtechnical analysis or indicators are constantly proposed and widely used. If the investor uses only one technical analysis method, the prediction of the trend of the market is bound to be not accurate, but if the investor uses a number of technical analyses, the investor suffers a loss when technical analysis methods in the trading signals shown conflicting. Meanwhile, the combination of technical indicators is often not the simple presentation that one plus one equals two, some may indeed be able to complement each other, but often they will interfere with each other. Therefore, how to integrate a number of technical indicators messages has become the urgent issue that the technology field faced, that is also the focus with many investors concerned.


what's wrong with the system. And creating a repair disk takes just minutes.

Columnists typically cannot reply to comments here, but do incorporate the best tips into future columns.

Two weeks ago I bought my stepson a new Samsung laptop with Windows 8 installed. It did not come with any support disks, or a backup partition. I added Norton's ghost32.exe to the Hirems CD, and then backed up the licenced Windows 8.1 onto an external USB hard drive. Now, if disaster strikes, I can quickly restore his operating system. Ghost32.exe is old, but still works.

We have a number of very similar windows 8.1 machines (some with same basic hardware, some with slight differences). Do I need to create separate Win8 'recovery drives' for each one or can I just make"rescue disk" utility allows me to make a disk, and then a second disk, but no more. I discovered this when I wanted to demo this utility to a friend; Windows would not made a third disk but instead gave me an error dialog box. I don't imagine that most of us would want to make more than one rescue disk, and surely two is enough, so this is not a major issue. I do wonder, though, if this "restriction" is a deliberate intention on the part of Microsoft, or a bug in the software.

Two weeks ago I bought my stepson a new Samsung laptop with Windows 8 installed. It did not come with any support disks, or a backup partition. I added Norton's ghost32.exe to the Hirems


wanted to do it and i trusted the install program.
dont remember what it deleted but the cdroms are gone from windows belief system
the usb ports are gone too. and the monitor was stuck at low rez.

now if there were a fixit kit that backed up all the key information then perhaps i could type it in and edit the registry or something to make the cdroms come to life to use a repair disk.

please add a final chapter to this article that includes a list of ALL the other info you may need and how to make it easily available for use in case of a failure.

Originally Posted by Kathleen Atkins

TOP STORY

Emergency repair disks for Windows: Part 1

By Fred Langa

When your PC won't boot from its hard drive,you might be dead in the water — unless you've created a bootable emergency repair disk or drive. Repair disks don't simply get PCs started; they also include tools that might fix what's wrong with the system. And creating a repair disk takes just minutes.


(uncommitted user edits are a good example).
The notion of a field editor that requires approval from the user is purely UI/View oriented. Whatever data is managed in that modality is purely in the domain of the view, and fetches/commits to the business-data should be discrete.

[Electrostimulation in the rehabilitation of patients with severe COPD: pertinent or not].
The degree of dyspnoea and muscular dysfunction during an exacerbation of COPD are so severe in some patients that they are unable to follow a traditional exercise training programme based on whole body activity (walking, cycling). Some alternative strategies like electrostimulation may be considered to initiate retraining as soon as possible, to break the vicious circle of exacerbations and improve the prognosis of these patients. Five randomised studies with a control group have analysed the effects of electrostimulation in COPD. They show that this technique does not cause dyspnoea and is well tolerated by the patients regardless of their severity; that that it can improve peripheral muscular function, effort tolerance, dyspnoea and quality of life. The preliminary


results seem to indicate that electrostimulation probably has a place in respiratory rehabilitation. We think that it should be considered as an alternative to classical retraining in COPD patients with loss of independence during an exacerbation. However, further larger, standardised studies are necessary to confirm the clinical and functional benefits of this technique, to understand the underlying mechanisms and define the precise therapeutic indications.One of the prompts asks you for the country - the UK, where the AppleCare Protection Plan was bought.

What follows is the message "Our records indicate that the service you are trying to use is not available in your location".

Or in English, "Our support service is broken, just like our Apple TV".

So why the rant?

Apple represented a dying breed of companies who believed that technology is an enabling thing that makes people's lives easier. But now it seems they are falling into the same trap of general sloppiness that blights the computer industry and the internet the world over.


The Destroyer is a very fast stable long distance driver. This disc is much like a faster Wraith, but with a little more high and low speed stability. Great disc for sidearm throwers and those with lots of power. Can handle headwinds and throws with off axis torque. Not suggested for beginning players.

The Wraith is a long stable Distance Driver with speed, glide and accuracy. This Wraith can provide great distance for players of all skill levels. It is an excellent down wind driver that also performs predictably into the wind. The Star Wraith is endorsed by 12-time World Champion, Ken Climo.

In lighter weights gives new players extra distance. Lighter weights also give players extreme range when thrown downwind, while maximum weights can give excellent upwind distance. Thewith a sharp overstable fade every time. Players who throw discs this hard are going to want them to maintain their flight characteristics. The Nuke OS is available in the hard, ultra-durable Elite-Z plastic.
Speed: 13.0
Glide: 4.0
Turn: 0.0
Fade: 4.0

A versatile high-speed disc is hard to find. They are usually too far on one side of the spectrum to be a true multi-tool. Introducing the Sheriff by Dynamic Discs. Long anhyzers, flex shots, pure hyzers; the Sheriff will arrive just in time to protect you from the onslaught of bogeys sure to come without the right disc. Attack the course with a new confidence knowing the Sheriff is standing with you to handle any problems that might arise.
Speed: 13 Glide: 5 Turn: -1 Fade: 2

The Archon is a new Speed


                   6
1365 (citing United States v. Tibesar, 894 F.2d 317, 319 (8th Cir.),
cert. denied, 498 U.S. 825 (1990)).       Even though Juror No. 28 was not
removed for cause, Gibson exercised his right to strike her with a
peremptory challenge.   Due to the removal of Juror No. 28 through a
peremptory challenge, the allegedly impartial juror "was thereby removed
from the jury as effectively as if the trial court had excused [her] for
cause."   United States v. Cruz, 993 F.2d 164, 168 (8th Cir. 1993)
(citing Ross v. Oklahoma, 487 U.S. 81, 86 (1988)).       Gibson has failed to
claim that any ofgiving Jury Instruction No.
11.

                                   VI.

      Gibson's fifth argument is that the district court erred by giving
Jury Instruction No. 14 defining possession.   Jury Instruction No. 14
was submitted by the Government from the Manual of Model Criminal Jury
Instructions for District Courts of the Eighth Circuit, Jury Instruction
8.02 (1994).   Gibson argues that the definition provided in this
instruction confused the jury by indicating that "constructive
possession is not really possession."

      "An instruction that correctly states the law is not erroneously
given even if the defendant did


16.

     Pursuant to Federal Rule of Criminal Procedure 16, the Government
must disclose to a defendant "that portion of any written record
containing the substance of any relevant oral statement made by the
defendant whether before or after arrest in response to interrogation by
any person then known to the defendant to be a government agent ...."
Fed.R.Crim.P. 16(a)(1)(A).   In the present case, Roberta Farr was not an
agent of the Government at the time Gibson made the statement to her.
As a result, Gibson's statements to Farr were not subject to the
disclosure requirement of Federal Rule of Criminal Procedure 16. See
also U.S. v. Hoelscher, 914 F.2d 1527, 1535 (8th Cir. 1990) ("[Federal
Rule of Criminal Procedure 16(a)(1)(A)] does not cover testimony by a
government witness as to an oral statement    // modified or not. This way files with different paths always result in different hashes and
      // files that are assumed to be modified get different hashes than all unmodified files.
      FastPaths.hashPathFast(hasher, relativePath);
      hasher.putBoolean(assumeModified);
    }
    return hasher.hash();
  }

  @Override
  public long getSize(Path path) throws IOException {
    return Files.size(path);
  }

  @Override
  public HashCode getForArchiveMember(Path relativeArchivePath, Path memberPath) {
    throw new UnsupportedOperationException("Not implemented");
  }

  private Path resolvePath(Path path) throws IOException {
    Path resolvedPath = defaultCellRoot.resolve(path);
    if (!allowSymlinks) {
      return resolvedPath;


heat. It also has a washer and dryer, outdoor sink to clean fish, charcoal grill, and a outside a propane cooker with pot.

I wasn't sure what to expect because there weren't any reviews yet when we booked. My whole family was very pleased when we got there! This is the perfect little place to get away and spend time together. We thoroughly enjoyed our stay there! The only small issue is that the bed was a little too small for my husband and myself (only by preference, we are used to a king size bed!) so we took turns sleeping on the couch, which was comfortable enough for a decent night's rest. There is no Wi-Fi (no surprise, they don't claim to have Wi-Fi on the listing) andin this warm and inviting home again! Sincerely, Michael

Michael2015-04-19T00:00:00Z

The cottage itself was beautiful, well-equipped, and clean, and all the thoughtful details and amenities made it feel perfectly cozy for our weekend trip. Shelly was a great host and easy to get in touch with. Highly recommended!

Shelly and her husband Nels made sure we felt at home at their cute cottage right from the beginning! The communication in advance was excellent and flexible arriving time was no problem (which we appreciated a lot). You can tell that they put a lot of time and effort into the cottage and paid attention to every detail. We had a great time and would love to come back one day!

Barbara2015-07-01T00:00:00Z

I feel so lucky to have found this place. An absolutely charming house


a lake view everyday makes you wish for your very own lake house. The place was exactly as described and everything else is indescribable, you would have to be here to experience. Edisto beach is about 1hr from here., great beach and bonfire area. Only thing is that the neighbors friendly dog (black and white) comes over. His name is "offensive and very questionable" so we rename him "Petey"

Toni2017-07-23T00:00:00Z

This is an awesome house! Connie and Aaron are great hosts who clearly have put a lot of work into this property. The house is right on the lake, and my friends and I were able to go fishing within minutes of waking up. The neighborhood was really friendly and quiet too. By the end of the trip, everyone stayingbeach on the Edisto River. A perfect place to unplug and enjoy the peace and quiet of country living. This a great spot for families looking to camp with amenities while having the privacy of acres and the enjoyment of a family farm. Bring a fishing rod, a cooler, and a guitar to play around the fire pit!

The listing suggests that you can "unplug" when you are here, and it is true. All 5 of us representing 3 generations, carry I- phones and look at them frequently. Internet is spotty, as is cell phone service, so we literally unplugged. There were a few hikes that were unexpected, and best of all, lots of time with the animals. The great tree swing was well used. At night we played


form a 3-6 membered, saturated carbocyclic or heterocyclic ring which may contain one or two heteroatoms selected from the group consisting of O, S, and N.
U.S. Pat. No. 7,186,731 discloses compound of formula (32) having DPP IV inhibiting activity and claimed to be useful in the treatment of conditions mediated by DPP-IV, such as non insulin dependent diabetes mellitus.
                wherein X1 and X2 each is independently lower alkylene; X3 is +CH2, +CHF or +CF2; R1 is a substituent as described in the patent specification, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.   group or the like, V represents -E-R7 (wherein E represents a single bond, —CO—, —(C═O)O—, or —SO2—; R7 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or the like)] or a pharmacologically acceptable salt thereof.
US 20040110817 discloses inhibitors (compounds of formula 38) of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, hyperglycemia, impaired glucose tolerance, metabolic syndrome (Syndrome X or insulin resistance syndrome), glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, conditions exacerbated by obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due


as DPP IV inhibitors and claimed to have utility in the treatment of non-insulin-dependent diabetes mellitus.

WO 2005033099 relates to DPP-IV inhibitors of the formula (44), and their analogs, isomers, pharmaceutical compositions and therapeutic uses. Such novel compounds are claimed to be potent and selective inhibitors of DPP-IV, and are effective in treating conditions that may be regulated or normalized via inhibition of DPP-IV. The invention also concerns pharmaceutical compositions comprising the novel compounds of formula (44), methods of inhibiting DPP-IV comprising administering to a subject in need thereof a therapeutically effective amount of said compound and processes for their preparation.

U.S. Pat. No. 6,395,767 discloses compounds of formula (45) as dipeptidyl peptidase IV (DP 4) inhibitors.
             as described in the specification.
WO 2007113226 describes compounds of formula (50) for the treatment of non-insulin-dependent diabetes mellitus.

WO 2007115821 discloses the compounds of formula (51) and their use as DPP IV inhibitors. The compounds were claimed to have utility in the treatment of diabetes and metabolic disorders.

Though number of compounds were found to posses DPP-IV inhibitory activity, most of the known compounds either lack potency or selectivity.
In search of better candidates having selective DPP-IV inhibitory activity the present inventors designed a series of DPP-IV inhibitors of formula (52) as disclosed in WO2009037719.
                wherein,        n=1, 2


d. heteroaryl such as thiophenyl; furyl; pyrazinyl; pyridyl unsubstituted or substituted with a substituent selected from halogen, cyano, methyl, benzyloxy;            e. N-acetylpiperidinyl;            f. Cyclohexyl;            g. Pyridine methyl;                        R2 is selected from hydrogen, CN, COOH, or isosteres of COOH, wherein said isosteres of COOH are selected from the groups consisting of esters, tetrazole, acid anhydrides, CH2OH, CH2OBn, CONHOH, CONH2;        R3 is selected from hydrogen, —CN, C2-C5a ‘qubit’, which can be represented as a quantum state *$\left|\psi\right\rangle$* in a two-dimensional complex vector space. This can be written as a *superposition* $$\label{eq1}
\left|\psi\right\rangle = \alpha_{0}\left|0\right\rangle + \alpha_{1}\left|1\right\rangle$$ where $\alpha_{0}$ and $\alpha_{1}$ are complex numbers satisfying $|\alpha_{0}|^{2} + |\alpha_{1}|^{2} = 1$. The quantum state of *N* qubits has the form $\sum{\alpha_{s}\left|s\right\rangle}$, where $s$ runs over all binary strings of length *N*. The $2^{\textit{N}}$ independent complex coefficients $\alpha_{s}$ then satisfy the normalization constraint $\left|\alpha_{0}\right|^{2} + \left|\alpha_{1}\right|^{2} + \ldots + \left|\alpha_{2^{N}-1}\right|^{2} = 1$. Each of the $2^{N}$ states $\left|000\ldots0\right\rangle$,$\left|000\ldots1\right\rangle$ …$\left|111\ldots1\right\rangle$ is shorthand for the *N-fold* tensor product $\left|0\right\rangle\otimes\left|0\right\rangle\ldots\otimes\left|0\right\rangle$, $\left|0\right\rangle\otimes\left|0\right\rangle\ldots\otimes\left|1\right\rangle$, …$\left|1\right\rangle\otimes\left|1\right\rangle\ldots\otimes\left|1\right\rangle$. Suppose a quantum state $\left|\psi\right\rangle$ of size $N$ is sent through a quantum noisy channel. The outcome of the transmission can be written as $E\left|\psi\right\rangle$, where the error operator


can be expressed as

$$\begin{aligned}
ZZXIX = (IIXIX) \times (ZZIII).\end{aligned}$$

Thus, we can directly express the $X$-containing operator and $Z$-containing operator as separate binary strings of length $N$. In the $X$-containing operator a $1$ represents the $X$ operator (likewise for the $Z$ operator), and $0$ for $I$. The resulting binary formalism of the stabilizer is a matrix $ A = \left(A_{1} | A_{2}\right)$ of $2N$ columns and $M = N-K$ rows, where $A_{1}$ and $A_{2}$ represent $X$-containing and $Z$-containing operators, respectively *Example 1:* For example, the set of stabilizers in (\[stabilizer\]) appears as the binary matrix $A$

$$\centering
\label{binaryStabilizer}
A = \left(A_{1} | A_{2}\right) = \left(\begin{array}{c|c}
\begin{array}{ccccc}
0 & 0 &  1 & 0 & 1 \\
1 & 0 &  0 & 1 & 0 \\
0 & 1 &  0 & 0 &curves. In this context we note the work of [@MHaga2010] in which LDPC code error performance is theoretically predicted for the binary symmetric channel as a function of a crossover probability $p_c$ and a different *initialization* probability. It would be interesting to investigate whether extensions of the concepts introduced in [@MHaga2010] could deliver the necessary theoretical framework for directly predicting quantum LDPC code performance as a function of the quantum Fisher information on the channel parameters.

Conclusion and future work
==========================

Utilizing quantum probes which are either in un-entangled pure quantum states or maximally entangled qubit pairs, we have explored how channel identification in the quantum depolarizing channel affects the performance of quantum LDPC codes. Our results show the importance in quantum communications of a viable channel identification campaign prior to


Geeks in Cambodia – Tech News from Phnom Penh - MichaelCrawford
http://geeksincambodia.com/

======
MichaelCrawford
I was quite gratified to stumble across this just now.

I started following the tragic events in Cambodia in 1972, when I was just
eight years old. I have never been there myself, but my father served in
Vietnam. Many years after the end of the war my father quietly said to me one
day, with no explanation whatsoever:

"We should not have been in Vietnam."

Advice/Recommendations for Traveling around Europe starting from Switzerland

Hello! Back in 2009 I became close friends with a Foreign Exchange student from Switzerland at my High School in Missouri. When she returned home, that following year I had the awesome background to visit her and spend an entire month in Switzerland with her family right before starting college. Back in 2012 we figured out we would *roughly be finishing our Undergrad programs at about the same time, and decided to keep the idea open of a big trip together again when that final year rolled around, and this is it! (She graduates in July, Ill finish my Capstone this Fall September-December). The last trip, we went all over Switzerland, but never crossed the border and to date that is


 for layer in range(hparams.num_hidden_layers):
        x, new_loss = common_layers.diagonal_conv_gru(
            x, (hparams.kernel_height, hparams.kernel_width),
            hparams.hidden_size,
            dropout=hparams.dropout,
            name="dcgru_%d" % layer)
      # Padding input is zeroed-out in the modality, we check this by summing.
      padding_inp = tf.less(tf.reduce_sum(tf.abs(inp), axis=[1, 2]), 0.00001)
      new_state = tf.where(padding_inp, state, x)  # No-op where inp is padding.
      return new_state, new_loss

    final_state, losses =is unchanged.

The new Pi has a quad-core processor that runs at 900MHz, compared to a single-core CPU that ran at 700MHz in the first generation. It's also an ARMv7 processor rather than an ARMv6 processor, which limited the software available on the original hardware.

Raspbian, a version of Debian compiled for the original Pi’s processor, will make another appearance on Raspberry Pi 2, but the ARMv7 processor should also allow volunteers to bring Ubuntu and other OSes to the hardware.

The new Pi will have 1GB of RAM, double the previous version. You'll be able to find links to distributors selling the new Pi at the Raspberry Pi website.

Raspberry Pi 2 is a “Model B,” though there is no Model A yet for the second generation hardware. Model A from


Q:

How can I complete "Waking Nightmare"?

I've found the potion Vaermina's Torpor but the next script has never been triggered, i.e. I can't tell him that I got that potion. I don't have that option:

Your next stop will be the Laboratory, where Vaermina's Torpor should be stored.  There are some more Invader Orcs and Vaermina Devotees that will need to be dealt with  as you go along. When Vaermina's Torpor is located, Erandur instructs you to drink it  and upon doing so, you become Casimir, a Vaermina Devotee during the Orc raid on the  temple. You are instructed to release the Miasma to protect the Skull.

I've tried to reset the character to no avail:

It is possible that reseting his location to the player will resolvecourt reporter and not transcribed.
[3]  We also cannot consider the action taken by the hearing officer to be relative to a motion for new trial. Under La.Code Civ.Proc. art. 1971, a new trial may be granted upon contradictory motion of any party or by the court on its own motion. However, nowhere in the record before us is there any inference of a new trial. The defendant asked for, and received, an "Amended Judgment." Further, we are aware of no statute or caselaw which would allow a granting of a motion to amend or clarify judgment to be the legal equivalent of a granting of a motion for new trial.
[4]  We also note that, in its appellate brief, defendant requests that "the portion of the amended


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18, 1975. However, both of these circuits use a standard telephone receiver which is efficient as a tone ringer output device. Both of these circuits also use resistor-capacitor controlled oscillators to determine the frequency of the tone output. Thus the accuracy and consistency of frequency control depends on the accuracy of the resistor-capacitor time constant and the electrical properties of the semi-conductor devices used in the oscillators.
Accordingly, it is the object of the present invention to provide an electronic tone ringer using a high efficiency transducer and consistent frequency control independent of the accuracy of a resistor-capacitor time constant and the electrical properties of semi-conductors. A further object is to provide reliable performance under low voltage conditions.electrically recorded slow oscillations under isoflurane anesthesia. (**Q**) Cross-correlation of optically and electrically recorded traces result in a prominent peak with almost zero time shift, indicating a close similarity of the two signals.\
10.7554/eLife.27602.005Figure 1---source data 1.Amplitude, duration and rise time values for quantification of OGB-1 slow calcium wave events (data shown in [Figure 1J--M](#fig1){ref-type="fig"}).Rise time, duration and amplitude of calcium transients were assessed and statistically compared in animals measured upon OGB-1 injections (n = 8 animals). Rise time was defined as time between onset of the transients and 50% of maximum intensity peak. Duration of the transients was defined as the time between the first and the last intensity value exceeding 50% of maximum intensity peak. Amplitude was determined as the intensity difference (∆f) from the baseline and the highest


[@bib77]; [@bib83]; [@bib81]; [@bib90]; [@bib105]; [@bib117]), and in natural slow wave sleep ([@bib63]; [@bib83]; [@bib97]; [@bib98]; [@bib99]; [@bib100]; [@bib103]; [@bib102]). Although the main features appear similar to those of the SWS oscillation ([@bib21]; [@bib83]), under anesthesia, slow waves appear more rhythmic and more synchronous across the cortex and also show longer silence periods ([@bib8]; [@bib15]).

During natural sleep, spindle activity - which is related to memory consolidation - is grouped by slow waves ([@bib72]), but this is not the case for anesthesia induced slow waves ([@bib71]). Nevertheless sleep slow waves and anesthesia slow waves may recruit the same cortical and subcortical structures ([@bib71]). Although cortically generated ([@bib99]; [@bib109]) slow waves also engage the thalamus ([@bib92]; [@bib97]; [@bib105]) and hippocampus ([@bib8]; [@bib42]; [@bib95]), suggesting that slow wave associated excitation playsto identify slow wave activity in electrophysiological recordings ([@bib90]). According to this algorithm, to detect slow waves, an EMA filter with a window of 25 ms was applied. Then, the datapoints of the filtered signal exceeding or falling below a threshold were used as preliminary transition points between slow calcium waves and silent periods.

To determine this threshold, amplitudes of all datapoints were sorted into a histogram. Onsets and durations for each threshold (in percent of maximum) were derived and the resulting numbers of active voxel of SPM-evaluations using these onsets and durations showed an inflection point at 70%, therefore the threshold was set to 70% for further evaluations ([Figure 2---figure supplement 2](#fig2s2){ref-type="fig"}).

Onsets of slow calcium waves were defined as signal timepoints exceeding the threshold (70%), termination of calcium


Mapshim, Bruker). Anatomical images were acquired with a T2-weighted 2D RARE sequence, TR/TE 2000/12.7 ms, RARE factor 8, 256 matrix, 110 × 100 µm² spatial resolution and slice thickness 1.2 mm, 6--16 contiguous slices prior to fMRI scans to check for tissue damage and validate the fiber's location. For BOLD fMRI measurements, T2\*-weighted images were acquired with a single-shot gradient echo EPI sequence with TR = 1 s (1.5 s for animals M1-M10), TE = 18 ms (14 ms for animals M1-M10), and FA 65°, 350 × 325 µm² spatial resolution (320 × 290 µm² for animals M1-M10), slice thickness 1.2 mm (0.8 mm for animals M1-M10), 9--16 continuous slices (34 for animals M1-M10), 2400 (n = 3), 1800 (n = 5) or 1200 (n = 10) acquisitions resulted in a scan time of 40, 30 or 20data, we correlated the mean signal of the ROIs for each subject with the timecourse of the pan-cortical component obtained from the previously calculated ICAs.

Electrophysiological recordings {#s4-8}
-------------------------------

In a series of control experiments (n = 3) simultaneous local field potential (LFP) recordings and calcium measurements (as described above) were performed outside the MR scanner. A pipette with a tip resistance of 0.2 MΩ filled with Phosphate Buffered Saline (Sigma, Munich, Germany) was inserted through a second craniotomy at a depth of 300 µm, lateral to the optic fiber insertion site. A reference electrode was inserted into the cerebellum, 1 mm posterior from Lambda and signals were amplified using an extracellular amplifier (EXT-02F/2, npi Electronics, Tamm, Germany). Signals were filtered at 300 Hz (low pass), digitized at 2 kHz and recorded together


is well known since the original description of the slow oscillation by Steriade et al., (1993). In those papers, also the synchrony with thalamus was established and then confirmed repeatedly, it is surprising that the thalamus shows no signal, slow oscillation in synchrony with cortex have also been shown in basal ganglia, why is there no signal in basal ganglia?

Why are these called calcium waves? Does it make reference to propagation? Or are these just increments in calcium signal with weak periodicity? Please clarify and be consistent throughout text.

I don\'t understand the statement in the subsection "Cortical slow wave--associated population activity can be reliably detected by optic calcium recordings during fMRI scans", or what its significance is. (\"This local confinement allows for a clear attribution of slow wavethe individual reviews below, we regret to inform you that your work will not be considered further for publication in *eLife*.

This study is very innovative with the use of cutting--edge calcium imaging techniques and the combination with fMRI. This combination can potentially provide critical insights into the relationship between neuronal activity and the BOLD signal used for fMRI studies. Thus, the study is very timely, as the use of fMRI approaches is becoming an increasingly important tool in translational neuroscience. While the reviewers acknowledged the improvement following the careful revision of the manuscript and the addition of the de--synchronized state, they also raised several important methodological and conceptual concerns. As you can read from the reviews, a major issue was the design and analysis of the fMRI study,


(1.1--1.8%) to induce and maintain slow wave activity. However, the rsfMRI network in \"slow--wave state\" (Figure 4---figure supplement 4A) is not a typical network observed in previous studies, while the \"active desynchronized state\" induced by medetomidine is consistent with previously reported rodent rsfMRI studies. It would be important to show typical rsfMRI networks, such as interhemispheric/bilateral somatosensory, visual and auditory networks (1--3) for both experimental conditions. Using ICA analysis, which the authors have already done, to identify such typical rsfMRI networks will be sufficient to address this concern.

2\) The isoflurane anesthesia used in this study was higher than previous rodent rsfMRI studies. In addition, Liu et al. showed that the interhemispheric somatosensory network gradually merged from a spatially specific network under light anesthesia (1.0% isoflurane) into a highlystate functional MRI has become an increasingly important tool to explore various neurological and psychiatric conditions. This approach, which was pioneered by Dr. Marcus Raichle, can be used to characterize addiction, demonstrate developmental changes in cortical connectivity between different brain regions and identify developmental delays. The importance of this approach is documented by an increasing number of publications in high profile Journals. A major limitation of this approach is that the relationship between the BOLD signal and neuronal activity is complicated and there are those that believe this signal reflects primarily hemodynamic changes rather then actual changes in neuronal activities. One of the main technical limitations is that the use of MRI technology is difficult to combine with conventional electrophysiological techniques, because the magnetic fields are disturbed by


slow wave activity.

We did now extend our discussion on these events; indeed we found very similar, if not identical, LFP signatures as others in the field (Kerr et al., 2005; Stroh et al., 2013; Busche et al., 2015).

> 2\) The procedure to estimate hemodynamic response function (HRF) should be carefully described. One puzzling issue is the time course of the HRF, which showed very fast onset time in comparison to the existing models ([Figure 2E, F](#fig2){ref-type="fig"}). The authors stated \"Time course of averaged HRs exhibited a sharp rise 0.7 s {plus minus} 0.4 s after the onset of a slow calcium wave.\" What does the \"sharp rise\" mean (equal to onset time?). If it is the case, please discuss the early onset of the estimated HRF by referringto the existing literature on this matter. If the authors presented the time courses of simultaneously acquired calcium and fMRI signal, would they have observed any phase shift? It will be better to provide a cross correlation curve to specify the temporal features of the two kinds of signals.

The different temporal domains of the neuronal response and the neurovascular response represents the main enigma of fMRI, this is not different in this study. It is rather a strength of this study that despite this drastic difference in timing, we can extract a BOLD correlate to individual slow waves states.

A cross correlation between these signals seems not to be meaningful, due to these drastic differences in timing.

> 3\) One of the key conclusions of this work is that the


we want to draw the reviewer's attention on a study conducted by Chen et al., (2013) showing slow calcium waves present under isoflurane anesthesia to promote mechanisms necessary for synaptic plasticity on the dendritic spine level. In this study the authors show that the same synapses which are activated while mice are subjected to sensory stimulation are also active during spontaneous up states (the single-cell equivalent to our population slow waves) and identify recurrent NMDAR-activation-dependent calcium signals occurring reliably in a subset of spines in cortical neurons during slow waves under subsequent anesthesia in the same animals. These findings were conducted under isoflurane anesthesia and suggest that these calcium signals represent a cellular substrate for synaptic plasticity and therefore memory consolidation.

> The authors should address these points instate of the network during resting state fMRI is unknown and variable. Taking into account recent findings in rodents showing that also during awake resting a type of slow wave activity (which is also very likely different from sleep regarding length of silence periods and other properties) is present in different cortical areas (Fernandez et al., 2016; McGinley et al., 2015), the presence of slow wave activity and its effects on BOLD becomes even more relevant for resting state measurements and their potential translational value. Additionally, our study is not merely correlating two signals as many other studies did before, it is directly relating a neurophysiological event -- the calcium slow wave -- to its potentially present BOLD correlate by employing a specific type of fMRI analysis (eventrelated),


be performed earlier in the pipeline, prior to smoothing (b) They are performing a manual process and not using an appropriate normalization algorithm and (c) Using a piece of software intended for the processing of visual (not neuroimaging) images. The authors should re--perform their pre--processing pipeline to incorporate coregistration and normalization prior to smoothing. Excellent choices are readily available in SPM12, which they are using.

The reviewer claims that the authors presumably co-registered images using Image-J. The reviewer expresses this concern as this would not correspond to a proper normalization. Here, the reviewer is mistaken since the authors did not perform any alignment. We clearly mentioned this in the subsection "fMRI analysis "cited by the reviewer that 20 beta-maps were overlaid, so a co-registration was not necessary in thisnumber of subjects. How do we know the resulting \'signal\' is not artificially boosted by the smoothing process?

The reviewer correctly argues that smoothing can sometimes artificially increase the SNR. Nevertheless, what the reviewer does not consider is the size of the smoothing applied. Typically, a large smooth can boost up the SNR, nevertheless the reviewer does not consider that the voxel size in our case is 350 x 325μm² spatial resolution (slice thickness 1.2mm) and the smoothing used is 500μm, what practically cannot increase the SNR by any means.

> c\) The lack of normalization and use of manual methods in ImageJ introduces many concerns regarding anatomic standardization among the various parts of this complex pipeline. It is not clear to this reviewer how integrity is maintained in comparing


However, given that the range of isoflurane levels as stated is very large, categorizing the individual animals based on their approximate experimental anesthesia levels would be very informative and should be added as a table, perhaps in the Supplement. Additionally, the authors should comment on how the different levels of anesthesia affected the network activity and how this was handled in interpreting their data.

We used relatively high levels of isoflurane concentrations as we were aiming to achieve slow wave activity around 0.1 Hz. As depth of anesthesia is highly dependent on the physiological state of the animal we relied on the online calcium signal readout we had available to ensure stable slow wave activity throughout the measurements and adjusted the isoflurane level accordingly, to achieve a rather uniformthis topic since decades employing electrophysiological methods), we are confident regarding the spatiotemporal precision of our event detection. The subsequently employed event-related fMRI analysis is well suited for this approach as any type of previously defined event, may this be brief epochs of stimulus presentation as in the classical use of this analysis within an event-related design in human fMRI, or neurophysiologically defined events extracted from our calcium signal, can be used as an regressor to detect related BOLD responses. Additionally, the approach is straight-forward as it is built-in for commonly used analysis software (spm) and therefore could be of advantage for many researchers, including translational human studies which have secondary readouts from EEG-signals. Other studies relating low-frequency activity (e.g. LFP signals, or the previously mentioned large-scale calcium


techniques (Yu et al., 2014) would be a way to resolve traveling slow waves in fMRI data in future studies as we now mention in the discussion of the revised manuscript version.

> In addition, a recent work by Leong et al. also demonstrated that the low frequency or slow waves can propagate robustly through long--range excitatory projections. Offering a multi--faceted view in the context of rsfMRI will definitely increase the impact of the present study.

We agree with the reviewer's comment and expanded the discussion upon this topic to ensure the mentioned multi-faceted view in the context on rsfMRI and cite the work of Leong et al., 2016.

> 5\) At present, the authors attempt to claim that cortex--wide BOLD activity was identified only in slow wave state but notrecent study by Chan et al., (2017) which we now cite, investigates this issue in beautiful detail.

As indeed we occasionally observed hippocampal BOLD activation during slow waves which we already reported in the previous version in the manuscript, we thank the reviewers for this comment and now conducted an atlas-based seed-ROI analysis for the hippocampus ([Figure 6---figure supplement 2](#fig6s2){ref-type="fig"}). This analysis revealed that voxel in the hippocampal ROI correlate well with cortical voxel, again spanning the entire cortical surface during ongoing slow wave activity, but lacking such a pan-cortical component under medetomine sedation.

> 7\) As stated in the previous review there was serious concerns related to the computational/analytic processing of the fMRI signal.
>
> -- The authors should provide a convincing argument that their \"global signal\" is not a


processing or acquisition artifact.

We fully agree with the reviewer´s comment that we have to rule out any sources which may result in the observed cortex-wide activity patters, and which are not related to the optically recorded slow waves. We now conducted a new set of analyses (set in italics) and we strongly believe that we demonstrate this very relation beyond reasonable doubt. We here mention possible sources of artefacts and address them point by point:

a\) Technical artefact

When slow wave vectors used as regressors for the subsequent BOLD fMRI analysis are temporally distorted, either by swapping them between animals/experiments or by temporally mirroring them, pan-cortical activation vanishes completely (Figure 3---figure supplement 4), *and the correlation between the GLM timecourse and the ICA component disappears ([Figure 5C](#fig5){ref-type="fig"})*. These results speakfor the slow wave events being temporally informative for these analyses.

b\) Physiological/non-physiological noise artefact

See A); in addition we compare these results to a type of neural activity which lacks the slow wave component and which is phenomenologically similar to an persistent/active type of ensemble activity when observing the calcium readouts ([Figure 5---figure supplement 3](#fig5s3){ref-type="fig"}). This physiological control for slow wave specificity of our results *indeed revealed the absence of a pan-cortical component also in seed-based analyses.* As both network conditions were achieved in the same animal, this rules out potential confounds or artifacts related to subject-specific noise, which would have been present in both measurements.

c\) Data processing artefact

We rely on three independent methods for the analysis of our data: (1) a classical GLM-based approach (event-related analysis employing simultaneously


across space could quantify the degree of binocular function after fusion but before stereopsis.

Previous studies showed that the human visual system is indeed able to detect interocular correlation in the zero disparity case and that it depends to some extent on the contrast of the monocular signals (Cormack, Stevenson, & Schor, [@i1534-7362-18-1-11-Cormack2]; Julesz & Tyler, [@i1534-7362-18-1-11-Julesz1]; Stevenson, Cormack, Schor, & Tyler, [@i1534-7362-18-1-11-Stevenson1]). Their stimuli were broadband in nature, being binary dots and they measured the detection of a level change in interocular correlation over the field of view. Kingdom and colleagues also looked at local mismatches between the two eyes that were still broadband (Jennings & Kingdom, [@i1534-7362-18-1-11-Jennings1]; Malkoc & Kingdom, [@i1534-7362-18-1-11-Malkoc1]). We are interested in the spatial properties of our interocular correlation sensitivity and use bandpass texturesby a sinusoidal oblique envelope of correlation (45° or 135°). So, at the peak of the sinusoid, the two patterns were maximally correlated and at the trough they were minimally correlated, creating a visual effect of luster (Jennings & Kingdom, [@i1534-7362-18-1-11-Jennings1]). Each eye\'s image was composed of two blended spatially filtered 2D fractal noise carrier: One of them was common in the two eyes *c~c~* and one was different *c~l~* or *c~r~*. Before blending, the two carriers were modulated by out-of-phase sinusoidal envelopes *m~c~* and *m~a~* at a frequency *f~m~* ¼ time the frequency of the carrier, which blending parameter *m* could be varied between 0 and 1, characterizing the amount of interocular correlation in the correlated stripes \[[Figure 1a](#i1534-7362-18-1-11-f01){ref-type="fig"} top row, [equation (1)](#jovi-18-01-05-e01){ref-type="disp-formula"}\]. $$\begin{document}\newcommand{\bialpha}{\boldsymbol{\alpha}}\newcommand{\bibeta}{\boldsymbol{\beta}}\newcommand{\bigamma}{\boldsymbol{\gamma}}\newcommand{\bidelta}{\boldsymbol{\delta}}\newcommand{\bivarepsilon}{\boldsymbol{\varepsilon}}\newcommand{\bizeta}{\boldsymbol{\zeta}}\newcommand{\bieta}{\boldsymbol{\eta}}\newcommand{\bitheta}{\boldsymbol{\theta}}\newcommand{\biiota}{\boldsymbol{\iota}}\newcommand{\bikappa}{\boldsymbol{\kappa}}\newcommand{\bilambda}{\boldsymbol{\lambda}}\newcommand{\bimu}{\boldsymbol{\mu}}\newcommand{\binu}{\boldsymbol{\nu}}\newcommand{\bixi}{\boldsymbol{\xi}}\newcommand{\biomicron}{\boldsymbol{\micron}}\newcommand{\bipi}{\boldsymbol{\pi}}\newcommand{\birho}{\boldsymbol{\rho}}\newcommand{\bisigma}{\boldsymbol{\sigma}}\newcommand{\bitau}{\boldsymbol{\tau}}\newcommand{\biupsilon}{\boldsymbol{\upsilon}}\newcommand{\biphi}{\boldsymbol{\phi}}\newcommand{\bichi}{\boldsymbol{\chi}}\newcommand{\bipsi}{\boldsymbol{\psi}}\newcommand{\biomega}{\boldsymbol{\omega}}\begin{equation}\tag{1}\eqalign{&{m_c}\left( x \right) =


(orange diamonds) and disparity (green squares) sensitivity functions. The gain for the disparity sensitivity is expressed in arcmin^−1^. (b) Peak frequency as a function of stimulus duration for the IOC (orange diamonds) and disparity (green squares) sensitivity functions. Error bars represent SD between subjects.](i1534-7362-18-1-11-f05){#i1534-7362-18-1-11-f05}

### Influence of contrast {#s3b1}

We now investigated the effect of a monocular or binocular contrast reduction on these two related sensitivities. The contrast was reduced to 0.3, 0.5, or 0.7 of the base contrast set for each spatial frequency (see [Methods](#s2){ref-type="sec"}).

The average IOC sensitivity as a function of spatial frequency for various fractions (i.e., 0.3, 0.5, 0.7, and 1) of the base contrast is plotted for a binocular contrast reduction in [Figure 6a](#i1534-7362-18-1-11-f06){ref-type="fig"} and for a monocular contrast reduction in [Figure 6b](#i1534-7362-18-1-11-f06){ref-type="fig"}. For both viewingagain, the disparity sensitivity increases with contrast and seems to be slightly lower in the binocular contrast reduction condition. In other words, a binocular contrast reduction has a bigger impact on the IOC and disparity sensitivity than a monocular one, but this difference seems very small.

This monocular/binocular difference concerning the effect of contrast on stereopsis goes in the opposite direction to that of a number of previous studies that have used narrowband test stimuli at low spatial frequencies (Halpern & Blake, [@i1534-7362-18-1-11-Halpern1]; Legge & Yuanchao, [@i1534-7362-18-1-11-Legge1]); however, it confirms the results of a number of other studies where spatially broadband stimuli---meaning containing high spatial frequencies---have been used (Cormack, Stevenson, & Landers, [@i1534-7362-18-1-11-Cormack1]; Hess, Liu, & Wang, [@i1534-7362-18-1-11-Hess1])

A quantitative assessment of the sensitivity function parameters is plotted in [Figure


demonstrating a second atypical pattern with two signals (red) for the RUINX1T1 locus, three signals (green) for the RUNX1T1 locus and no fusion signal for RUNX1-RUNXT1.](fonc-09-01016-g0002){#F2}

46,XX,der(8)t(8;21)(q22;q22),der(21)t(8;21)del(8)(q22q22)(20).nuc ish(RUNX1T1x2,RUNX1x3)(RUNX1 conRUNX1T1x1)\[92/200\]/(RUNX1T1x2,RUNX1x3)\[92/200\], (TP53x1,CEP17x2)\[37/200\], (ASS1,ABL1,PML,CBFB,RARA,BCR)x2\[200\].

### Molecular Pathology Assays

Pathogenic mutations were found in three genes: ASXL1, DNMT3A, and IDH1 ([Table 2](#T2){ref-type="table"}). The studies of JAK2 V617F mutation and internal tandem duplications (ITDs) in the FLT3 gene were both negative.

ASXL1 encodes a chromatin-binding Polycomb group (PcG) protein involved in transcriptional regulation ([@B19]). Somatic mutations in ASXL1 have been reported in 10.8% adults with *de novo* AML, and in 17.2% of AML cases with intermediate risk cytogenetics ([@B20], [@B21]). DNMT3A encodes DNA (cytosine-5)-methyltransferase 3A and is essential for establishing genome-wide patterns of CpG methylation during development. It is also important for regulating gene expression, parental imprinting,are not well-characterized.

### Outcome

The patient underwent treatment with conventional idarubicin and cytarabine induction. This was complicated by neutropenic fever without an identified infectious source and the development of a rash that was thought to be due to cytarabine. A cytogenetic CR was achieved. Molecular profiling was not repeated at the time of her remission bone marrow biopsy. She proceeded immediately to consolidation with high dose cytarabine. Unfortunately, she completed 3 cycles and then her disease relapsed. Cytogenetics at the time of relapse showed the same t(8;21), and molecular profiling identified the same mutations in ASXL1, DNMT3A, and IDH1 that were present at diagnosis. She underwent re-induction on a clinical trial, however, her disease was refractory. She subsequently began treatment with an IDH1 inhibitor and her disease was stable


       var data =  $('#campaign-form').serialize();

        $.ajax(
            {
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                type: 'POST',
                url: "campaigns/sequenceupdate",
                data: { 'campaign_uid' : $(this).attr('data-campaign'), csrf_token: csrfTokenValue },

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^^ that same button clicked has to save what is currently on the view and then load contents for the button clicked. I am appending an ID of the Model needed to the button when user clicks #copy-link and saving it automatically

A:

Im not a jQuery wiz but you can do this with straight up javascript in conjunction with Jquery.
function postInfo(event){
    httpRequest = new XMLHttpRequest();
    if (!httpRequest) {
      alert('Giving up :( Cannot create an XMLHTTP instance');
      return false;
    }
    httpRequest.onreadystatechange = results;
    httpRequest.open('POST', 'ENTER YOUR URL HERE');
    httpRequest.setRequestHeader('Content-Type', 'application/x-www-form-urlencoded');
httpRequest.send('serverpin='+ServerPIN+'&restuarantid='+RestaurantID); //<-these are the variables you are posting
  }

function


Speed of A Car

Detect Shaking

Count Your Steps While Walking

Getting set up is a little tricky, but, don’t worry, I’ll walk you through it. And if you have any problems you can ask for help through the discussion forum. I’ll show an easy method to enable and acquire data from all 5 iOS sensors including:

Acceleration Sensors — Learn how to use abrupt changes in your iPhone’s movement

— Learn how to use abrupt changes in your iPhone’s movement Magnetic Field Sensors — Explore magnetic fields used by the compass and other input devices

— Explore magnetic fields used by the compass and other input devices Orientation Sensors — See how you can detect your iPhone state and control virtual items

— See how you can detect your iPhone state and control virtuallogger->log(spdlog::source_loc{SPDLOG_FILE_BASENAME(__FILE__), __LINE__, SPDLOG_FUNCTION}, level, __VA_ARGS__)

should be
#define SPDLOG_LOGGER_CALL(logger, level, ...)  \
    do \
        if (logger->should_log(level)) \
            logger->log(spdlog::source_loc{SPDLOG_FILE_BASENAME(__FILE__), __LINE__, SPDLOG_FUNCTION}, level, __VA_ARGS__) \
    while (false)

The do ... while trick ensures that the output of the macro can be used as a simple statement. That's not true of the if statement that the original macro output which, as you found, is going to mess up any if ... else statement it finds itself in.
Maybe you could join the project and push this fix.


                = IPv4

A:

It looks like the tcpdump output contains only requests and not any responses at all. If this is what is actually happening, then a timeout error is to be expected.
In the server_args line of your TFTP configuration for xinetd, you have -u tftp. That tells in.tftpd to run as user tftp. In light of that, this message logged by in.tftpd might be important:
Jan 15 13:13:21 tools in.tftpd[7955]: no user tftp: Success

It says "no user tftp". Does the tftp user account actually exist on your system?
The Success at the end of the log message requires a bit of C programming knowledge to understand. It is likely to come from a minimalist error-handlingout that such user does not exist. So the in.tftpd process outputs that log message and dies without sending anything to the client.
The terse message with a misleading "Success" at the end is an example of the old concept of "if your only tool is a hammer, you tend to treat everything as nails." In this case, the programmer has probably used their only error handling function in a situation to which its output format does not quite fit.
Also, these requests look a little odd:
12:34:33.477401 IP 172.16.1.202.ah-esp-encap > tools.dmz.tuxme.dk.tftp:  27 RRQ "pxelinux.0" octet tsize 0
12:34:35.481131 IP 172.16.1.202.acp-port > tools.dmz.tuxme.dk.tftp:  27 RRQ "pxelinux.0" octet tsize 0
12:34:39.490793 IP 172.16.1.202.msync > tools.dmz.tuxme.dk.tftp:  27 RRQ "pxelinux.0" octet tsize 0
12:34:45.477712 IP 172.16.1.202.gxs-data-port > tools.dmz.tuxme.dk.tftp:  27 RRQ "pxelinux.0" octet tsize


state statute which was said to permit the offending conduct.

21
Adickes v. Kress, 398 U.S. 144, 90 S. Ct. 1598, 26 L.Ed.2d 142 (1970), also was concerned with conduct of a private enterprise said to be in violation of Sec. 1983.  The Court there pointed out that the involvement of a policeman in a conspiracy situation provides the necessary ingredient of state action in a claim of violation of the Fourteenth Amendment, whether or not the actions of the officer were officially authorized.  The Court also said:

22
"Whatever else may also be necessary to show that a person has acted 'under color of [a] statute' for purposes of Sec. 1983 . . . we think it essential that he act with knowledge of and pursuant to the statute."was not taken in this case.  The service was disconnected by the defendant at its pole, some distance removed from the home of the plaintiff.

40
Thus the action of the company in terminating service in this case was taken pursuant to its own regulations using its own personnel without entering onto the customer's private property, without utilizing any state statute or regulation permitting re-entry on the customer's premises, and without any specific direction or authorization of the regulatory body.

41
The factual background in this case is quite similar to that in Lucas v. Wisconsin Electric Power Company, 466 F.2d 638 (7th Cir. 1972), cert. denied, 409 U. S. 1114, 93 S.Ct. 928, 34 L.Ed.2d 696 (1973), where the Court of Appeals for the Seventh Circuit, sitting en banc, held


Telephone Co., 441 F.2d 1116 (9th Cir. 1971), where that Court said:

46
"The fact that a private corporation, such as Pacific Bell, enjoys an economic monopoly which is protected and regulated by the state does not necessarily bring its every act within the purview of Section 1983.  [citation], for as well stated in Powe v. Miles, 407 F.2d 73, 81 (2d Cir. 1968), 'the state must be involved not simply with some activity of the institution alleged to have inflicted injury upon a plaintiff but with the activity that caused the injury."'

47
In Palmer v. Columbia Gas Company, 479 F.2d 153 (1973), a panel of the Court of Appeals for the Sixth Circuit came to a contrary conclusion in a situation where the utility availed itself of a rightextensive regulation of the Liquor Control Board, a differing result was reached in Burton, supra, where a public restaurant was involved but less state control was evident.  It may well be that the underlying reasoning for the differing results in the two cases is that in Moose Lodge the national prohibition against racial discrimination had come into conflict with the fundamental right of free association, while in Burton the tension arose between discrimination and the freedom to operate a business which should have been open to the public at large.  In this analysis, it is not at all clear that the result in Moose Lodge would not have been different had the discriminating defendant been a public utility rather than a private club.

50
It is important, therefore,


is to continue to receive the service and, we assume, pay for it on a current basis until such time as a decision can be had on the disputed items.

56
The utility's response is that the plaintiff may pay the contested charge and then claim for a refund.  This process, it is assumed, may be handled informally and perhaps without the necessity of going to court.11  Though not explicitly stated as such, there is an underlying premise in plaintiff's position that because her income is limited to payments made by the Department of Public Welfare, the refund claim process is not a practical alternative to her.  If we are to accede to this contention though, it should apply to every indigent person, not only as to92 S.Ct. 862, 31 L.Ed.2d 36 (1972), the Court said:

63
"We do not denigrate the importance of decent, safe, and sanitary housing.  But the Constitution does not provide judicial remedies for every social and economic ill.  We are unable to perceive in that document any constitutional guarantee of access to dwellings of a particular quality, or any recognition of the right of a tenant to occupy the real property of his landlord beyond the term of his lease without the payment of rent or otherwise contrary to the terms of the relevant agreement."

64
The Lindsey case dealt with a summary form of eviction used in Oregon which required payment by the tenant in order to maintain possession and required that any defenses other than payment be reserved to


See Shelton, supra, f. n. 9

13
 Plaintiff has not raised in brief or argument any objection to the provision in the tariff reserving the right to discontinue without notice in the event that there has been tampering with the meter by the customer.  Since there is no evidence that it is applicable here, we do not consider it

14
 The "entitlement" cases generally deal with a privilege or right conferred by the state of something which it alone can grant, e. g., in Bell v. Burson, 402 U.S. 535, 91 S.Ct. 1586, 29 L.Ed.2d 90 (1971), only the state, not a private company, can issue a driver's license; only a state by appropriation and legislative action may administer and disburse welfare benefits, Goldberg v. Kelly, 397 U.S. 254,USA TODAY poll taken March 22 — a day after the House approved the legislation — in which a 49%-40% plurality called the bill “a good thing.”

“Any one-day poll in the immediate aftermath of a major event is likely to be subject not only to sampling error but also to very short-term effects,” says political scientist Charles Franklin of the University of Wisconsin-Madison. At the time, “the news cycle was dominated by the positive side of the story, and only a little bit by the Republicans’ rebuttal to that.”

The undeniable problem for Obama and the Democrat is that a two-thirds majority of the American public simply does not believe their talking points on health care reform, making any increase in popularity unlikely and further declines probable:

Nearly two-thirds of


system, for the quality of their care and, among the insured, for their coverage. Majorities in the new poll also see the changes as resulting in higher costs for themselves and for the country.

Most respondents said reform will require everyone to make changes, whether they want to or not; only about a third said they believe the Democrats’ contention that people who have coverage will be able to keep it without alterations. And nearly two-thirds see the changes as increasing the federal budget deficit, with few thinking the deficit will shrink as a result. The Congressional Budget Office said the measure will reduce the deficit.

About half of all poll respondents said the plan creates “too much government involvement” in the health-care system, a concern that is especially pronouncedDC to show disapproval of the pending Obamacare legislation

In a rally against Obamacare called for only twenty four hours ago, at least 25,000 Americans have now arrived in Washington, DC to protest the potential House passage of the comprehensive health care reform package known as Obamacare. Right now, various speakers are talking to the growing crowd in front of Capitol Hill as every major highway into Washington DC remain jammed with cars, trucks and buses carrying yet more protesters to join the rally against Obamacare. Of course, the establishment media is ignoring this growing flash protest on Capitol Hill and instead only reporting on the claimed momentum of undecided votes turning in favor of Obama’s gigantic comprehensive health care plan. The President’s media allies, of course, are under-reporting


Senate bill’s imperfections.

But the so-called “fix” bill isn’t ready and there is no expectation CBO will deliver preliminary cost estimates Wednesday. That pushes the schedule back because House Democratic leaders cannot begin the final whip process (counting “yes” and “no” votes) until it has a full “fix” bill with a concrete CBO score on costs, revenues and deficit implications.

In other words, there’s a lot of work left to be done and not much time to finish it. What may well be happening is House Democrats and the White House are agreeing to disagree — on the timing, not the objective.

Obama was talking about the differences between himself and his then-opponent in the Democratic primary, Hillary Clinton.

“I think it is legitimate at this point for me to explain very.

The man was calm as he approached the officers at the main entrance around 6:40 p.m., Pentagon Police Chief Richard Keevil said at a news conference. The officers asked to see his pass to enter the building; he started shooting without saying a word.

“He reached into his pocket and they assumed he was going to get out his pass and he just started shooting,” Keevil said. The officers were only “grazed” and immediately fired back.

President Barack Obama Used the Term "Obamacare" for the First Time during Thursday's Health Care Summit

One interesting development went completely unreported during or after the festivities at the health care summit last Thursday: for the first time, President Barack Obama referred to his own signature comprehensive health care reform initiative as “Obamacare”. Obama used


transfer this action to Vermont is granted, on condition that defendant appear generally in the action once it has been transferred.
Defendant's third motion, i. e., to strike the note of issue or to extend defendant's time to object to it, is rendered moot by the decision to transfer the action and accordingly, is denied on that ground.
Settle order on notice.
that has the script attached. You don't know about it or you forgot about it.
(*) Remember too that Prefabs can easily catch you out in Unity.  Don't forget you can only set inspector drags "within" prefabs in Unity - it's a bit confusing. In a prefab, you can't connect to anything in the "outside world", to the scene.


and Infinium 450K of more than 20%. Roessler et al.[@R23] found 63.8% of the 340 CpGs studied in cell lines and 60.5% of the 352 CpGs studied across primary tumor specimens showed a difference between Infinium 450K and pyrosequencing of less than 10%. This is a lower level of agreement than we see in our raw data (73% of 454,660 assays agree within 10%) and much lower than after Infinium 450K data processing (82% of 454,660 agree within 10%), [Table 2](#T2){ref-type="table"}. The discrepancy could be due to the less sensitive nature of the pyrosequencing comparison or the more variable nature of the malignant tissues under study. The authors also found little improvement in the concordance of their Infinium 450K data with pyrosequencing after type II peak correction. Thistime for 48 samples on Infinium arrays (including data analysis) is 5 days, whereas the RRBS analysis takes about 14 days per 8--16 samples. Infinium 450K requires less starting DNA (between 0.5 to 2 µg, compared with 5µg for RRBS) and is compatible with DNA samples extracted from FFPE preserved tissue. Currently the Infinium 450K offers a high-throughput low cost alternative for large studies, enabling the processing of the hundreds or thousands of samples required for EWAS.[@R13]^,^[@R33] We observe that in clinical samples intermediate methylation values (20--80%) are more variable between technologies than values at the extremes of the bimodal methylation distribution. This is in agreement with the findings of Roessler et al.[@R23] but demonstrated across many more CpGs and using a different comparator technology (RRBS as opposed


probe intensity and the overall intensity, β-value for an i^th^ interrogated CpG site:

![](epi-7-1173-e2)

Where y~i,methy~ and y~i,unmethy~ are the intensities measured by the i^th^ methylated and unmethylated probes respectively, averaged over the replicate beads. a is a constant offset, by default 100. Therefore β-values range between 0--1 with 0 representing no methylation and 1 representing 100% methylation. R protocol is supplied in the Supplemental Materials.

β-values were further processed to scale the % methylation range of the type2 probes to the type 1 probes using the procedure suggested by reference [@R19], R protocol is supplied in the Supplemental Materials.

RRBS.
-----

The full details of the experimental procedure for RRBS are elaborated in Lee YK, 2012, submitted. Briefly, 5 µg genomic DNA was fragmented by sequential restriction enzyme digestion for 2 h eachElectronic displays are ubiquitous in today's world. For example, mobile devices such as smartphones and tablet computers commonly use a liquid crystal display (LCD) or an organic light emitting diode (OLED) display. LCDs and OLED displays are both examples of flat panel displays, and are also used in desktop monitors, TVs, and automotive and aircraft displays.
Many color displays, including many LCD and OLED displays, spatially synthesize color. In other words, each pixel is composed of three sub-pixels that provide a different color. For instance, each pixel can have a red, green, or blue sub-pixel, or a cyan, magenta, or yellow sub-pixel. The color of the pixel, as perceived by a viewer, depends upon the relative proportion of light from each of the three sub-pixels.
Color information for a display


8.05.2013

The Geranium Dress - Straight Up

After sewing the geranium dress with so many modifications, I looked forward to sewing it again according to the pattern instructions. This time, straight up.

It did not disappoint. It came together easily and was a joy to sew.

Except for the buttonholes. Or perhaps more accurately, the buttonhole. The first two went in beautifully. But on the third, my buttonhole foot got hung up on the thickness of the seam allowance (where the bodice and skirt join). I nearly lost my mind trying to make that third buttonhole work. I won't bore you with the details. Just believe me when I acknowledge that it wasn't pretty. What can I say? My machine is buttonhole persnickety.

If I were to sew this dress again in thison the dress! thanks so much for the sweet words!

So sweet! And I love the attempt to photograph all four children - hilarious!! In the first one, not a single kid is pointing even ONE eye towards the camera! Photographing children, especially in groups, is like HERDING CATS. Exhibit A, see photo above. Love it.

You want to know the truth? I just eyeball the button placement on the Geranium and edge that bottom button up until it's out of the seam allowance and adjust the rest accordingly. I have no idea where the "suggestedplacement" is because I've never checked it. So that's how I have handled this problem - by not even realizing there was a problem! That's just how I roll, people. :-)

i really love photography and


for immunofluorescence microscopy
-----------------------------------------------

HUVECs were fixed in 4% paraformaldehyde (w/v) for 30 min at room temperature and blocked in 1 × phosphate-buffered saline (PBS), 0.01% Triton X-100 (v/v) and 5% goat serum (v/v), and then incubated with primary antibodies overnight at 4 °C. Then cells were rinsed in 1 × PBS three times and incubated with corresponding secondary antibodies 1 h at 37 °C. For negative controls, cells were incubated with normal IgG. CLSM involved a Leica TCS SP2 AOBS apparatus. Different fields of view (\>3 regions) were analyzed on the microscope for each labeling condition, and representative results are shown.

PC-PLC activity assay
---------------------

PC-PLC activity was measured by the Amplex Red PC-PLC-specific assay kit (Molecular Probes A12218, Eugene, OR, USA) with modification.^[@bib39]^ After several steps of enzyme-coupled reactions with 10-acetyl-3, 7-dihydrophenoxazine (Amplex Red reagent),by learning to play a song than just doing the exercises.  But the exercises are necessary in the beginning.
As you build finger strength and callouses it will become easier to play more chords.
Here are some links to other stack exchange answers that will be valuable resources to you as a beginner.
Using a capo to transpose to different keys using your favorite chord shapes
Custom easier to play string set for those just starting to learn guitar
Just remember, the hardest part comes in the very beginning but if you stick with it and understand that it does take dedication and consistent tedious practice, you will soon start making advances very rapidly.  If you can just stick with it until you can


The Arts, Vol. 2: Reviewing November 1921 (Classic Reprint) PDF

PDF-0ba65 | Excerpt from The Arts, Vol. 2: Reviewing November 1921The picture is a happy union of two sometimes antagonistic elements, decoration and realism. The upper half is almost pure realism, – the grove of stately palms, their leaves touched by the declining sun against a background of pinky-lavender hills and tropic sky. In the lower half, on the other hand, two strange and solemn figures sit in shado… The Arts, Vol. 2: Reviewing November 1921 (Classic Reprint)

Download eBook The Arts, Vol. 2: Reviewing November 1921 (Classic Reprint) by Hamilton Easter Field across multiple file-formats including EPUB, DOC, and PDF.

PDF: The Arts, Vol. 2: Reviewing November 1921 (Classic Reprint)

ePub: The Arts, Vol. 2: Reviewing November 1921 (Classic Reprint)

Doc: TheQ:

JQuery - perform task on browser close event

Very simple question. I need to perform a task when the user closes his browser.
I'm aware of the functions below:

$(window).bind("beforeunload", function() {
    return false;
})

$(window).unload(function() {
    return false;
})

But both of these - bring up an alert asking the user - "Stay on this page" - "Leave this page" (atleast on Chrome).
I dont want that to happen. I just want to perform a task when he closes it like updating the time on the DB as to when he left.
Any ideas
Thanks

A:

This is impossible to be done cross browser properly since Opera does not actually support it :\ as stated here: cross-browser Onunload and Onbeforeunload ? (particularly opera 11) and in many other well documented places.
Also


accuracy. High resolution spectra of water and carbon dioxide transitions at 1.77 µm, 1.96 µm and 2.06 µm show that the molecular transmission acquired with this system operating in the field-mode did not deviate from those measured when it was referenced to a maser and cavity-stabilized laser to within 5.6 × 10<sup>-4</sup>. When optimized for carbon dioxide quantification at 1.60 µm, a sensitivity of 2.8 ppm-km at 1 s integration time, improving to 0.10 ppm-km at 13 minutes of integration time was achieved.nominator of 37/510 and 61/42?
3570
Calculate the lowest common multiple of 1 and 43.
43
What is the least common multiple of 20 and 2884?
14420
What is the lowest common multiple of 8 and 484?
968
Calculate the common denominator of -57/8 and -73/100.
200
What is the common denominator of -43/960 and -103/720?
2880
What is the common denominator of 37/4 and 47/772?
772
What is the common denominator of 38/765 and -21/25?
3825
Find the common denominator of -93/10 and -143/120.
120
Calculate the common denominator of 49/720 and 16/501.
120240
What is the lowest common multiple of 1326 and 20?
13260
What is the common denominator of -29/8 and 63/310?
1240
Calculate the lowest common multiple of 20 and 24.
120
Calculate the common denominator of -77/18 and 7/4968.
4968
What is the lowest common multiple of 143 and 66?
858
What is the least common multiple of 210 and 960?
6720
Calculate the smallest


Q:

When did mechanical tower clocks start being used?

On a tour of the Royal Observatory at Greenwich I saw the following display on the history of mechanical clocks:

The suggest that mechanical clocks and astronomy weren’t really combined in England until the 16th century.
Now I thought mechanical clocks came into use in the 13th century.
My question is: When did mechanical tower clocks start being used?

A:

In 14th century, but it is not known precisely, where and when was the first clock made. Salisbury cathedral has on display something they call the "oldest surviving clock", made in 1386. But similar claims are made about some French and Italian cocks for which they give earlier dates.
See   https://en.wikipedia.org/wiki/Salisbury_cathedral_clock
This is about mechanical (weight-driven) clocks. Water clocks are much older,
exist since antiquity,
Patterns of Death in the South Still Show the Outlines of Slavery - iamthirsty
https://fivethirtyeight.com/features/mortality-black-belt/
======
fmitchell0
As an engineer, I always get frustrated when it seems like a lot of our
customers are more concerned with the perception of the existence of
something, rather than its actual existence. I'm continuing to learn (UX not
withstanding) that just because you solve a problem, it doesn't mean the user
believes the problem is solved.

As a black engineer, I've often thought that if there were data, science,
math, and straight forward research on the more than $300B+ the slavery system
provided for the U.S. in free labor (think of the biggest costs to business)
and it's effects, that maybe we could have a conversation about data-driven
solutions. Think of how we've added data to sports and created a new economy
on improving outcomes


this one bundles previously released titles (Wagner and the classic Metropolis) with new ones; in this case, the debuts are Woman in the Moon and Spies. Meanwhile, Criterion offers a two-disc reissue of one of their own titles, Lang's magnificent M; the film's image is vastly improved, and a disc full of great bonus features offers an incentive for owners of the first edition to upgrade.

Film buffs who discovered British television pioneer Dennis Potter via the recent reissue of The Singing Detective are heartily encouraged to check out Pennies From Heaven (BBC Video), a three-disc set containing the musical miniseries that shares Detective's fascination with yesteryear's glamorous pop songs. Widely considered one of the greatest television programs ever, Pennies (not to be confused with the American remake starringweb design, Clean web design,

Editor note: This post is the series of weekly web design inspiration. Feel free to submit your recommendation. Check it out this weekly web design and let us know what do you think.

Passion is beyond limitation. If you’re passionate about ANYTHING, nobody can stop you not to do what you want. Blogging and Web Designing is my passion that don’t drive me to do what I want but push me as well to share fanatical stuff with people.


//
// is_read_buffered.hpp
// ~~~~~~~~~~~~~~~~~~~~
//
// Copyright (c) 2003-2016 Christopher M. Kohlhoff (chris at kohlhoff dot com)
//
// Distributed under the Boost Software License, Version 1.0. (See accompanying
// file LICENSE_1_0.txt or copy at http://www.boost.org/LICENSE_1_0.txt)
//

#ifndef BOOST_ASIO_IS_READ_BUFFERED_HPP
#define BOOST_ASIO_IS_READ_BUFFERED_HPP

#if defined(_MSC_VER) && (_MSC_VER >= 1200)
# pragma once
#endif // defined(_MSC_VER) && (_MSC_VER >= 1200)

#include <boost/asio/detail/config.hpp>
#include <boost/asio/buffered_read_stream_fwd.hpp>
#include <boost/asio/buffered_stream_fwd.hpp>

#include <boost/asio/detail/push_options.hpp>

namespace boost {
namespace asio {

namespace detail {

template <typename Stream>
char is_read_buffered_helper(buffered_stream<Stream>* s);

template <typename Stream>
char is_read_buffered_helper(buffered_read_stream<Stream>* s);

struct is_read_buffered_big_type { char data[10]; };
is_read_buffered_big_type is_read_buffered_helper(...);

} // namespace detail

/// The is_read_buffered class is a traits class that may be used to determine
/// whether a stream type supports buffering of read data.
template <typename Stream>
class is_read_buffered
{
public:
#if defined(GENERATING_DOCUMENTATION)
  /// The value member is true only if the Stream type supports buffering of
  /// read data.
  static const bool value;
#else
  BOOST_ASIO_STATIC_CONSTANT(bool,
    and kringle-dependent interactions, respectively. Under the experimental conditions employed, Glu-plasminogen exhibited no binding to fibrin, whereas Lys-plasminogen bound to a single class of sites with Kd = 0.25 microM and n = 1.02 plasminogen/fibrin. This binding was completely inhibited by EACA and 50% displacement occurred at [EACA] = 28 microM. Competition experiments indicated that Lys-plasminogen does not displace either tPA or delta FEIX from fibrin. From these results the conclusions are drawn that tPA can interact with intact fibrin by two different and independent modes, involving, respectively, the finger and kringle 2 domains, and neither of these modes are competitive with the kringle-dependent binding of Lys-plasminogen.


will be provided by Bob/Main
Street Automotive on Tech Day:

•4-Wheel Alignment - $79.95 - only 3 will be
scheduled for this date so book early

•Installation of Miata Accessories

•Installing new Wheels and Tires, or changing
your winter snows for you summer tires for those of you who drove
through the winter. (Please call ahead if you need new tires and
would like us to provide them). Please note: Any parts provided
by Main Street Automotive will include the standard parts mark
up.

Note that you must call or email
ahead of time to schedule larger jobs like alignments, custom
exhaust/pipe bending work and tire mounting/balancing so you
won't be disappointed if there are no openings left when you
arrive.

There is no charge for you doing your own
work with your own parts and fluids. Should you need them; the
following will be available  : num [1:13081] 1 1 1 1 1 1 1 1 1 1 ...
  ..$ leftPos: num [1:13081] 736092 818159 4105086 4140849 4464314 ...
  ..$ Means  : num [1:13081] 117 152 224 121 196 ...
 $ OC_AH_096T  :'data.frame':   13081 obs. of  3 variables:
  ..$ chr    : num [1:13081] 1 1 1 1 1 1 1 1 1 1 ...
  ..$ leftPos: num [1:13081] 736092 818159 4105086 4140849 4464314 ...
  ..$ Means  : num [1:13081] 49.5 102.8 93.6 15.2 103.2 ...

I am trying to calculate all the significant scores for each of the third column of each dataframe (Means grouped into bins using dplyr) and if they are significantly elevated they are ascribed


a 1 ,significantly depressed a -1 and neither, a zero in a new column for each dataframe.
To do the grouping I have done as follows which works fine:
CLL <- function (col) {
col <- col %>%
  group_by(chr, binnum = (leftPos) %/% 500000) %>%
  summarise(Means = mean(Means)) %>%
  mutate(leftPos = (binnum+1) * 120000) %>%
  select(leftPos, Means)}

CML<-lapply(df_list, CLL)

I am stuck on then calculating the upper and lower limits for each Means column in each dataframe.  I think this is because I do not know how to reference this column because it is in a list of dataframes. For a non list dataframe I use:
UL = median(col2, na.rm = TRUE) + alpha*IQR(col2[1], na.rm = TRUE)
LL = median(col2, na.rm = TRUE) - alpha*IQR(col2, na.rm = TRUE)

I have triedotherwise let me know and I will correct the answer).
data.table way
For the sake of the completeness, I incude a data.table-way, which is faster (but gets rid of the list-structure). The approach looks like this:
library(data.table)
library(magrittr) # for some piping

# combine all listed data.frames to one data.table with another column, which indicates the name
dt <- lapply(1:length(df_list), function(i) {
  nam <- names(df_list)[i]
  df <- df_list[[i]]
  tmpdt <- data.table(name = nam, df)
}) %>% rbindlist

# calculate the limits
alpha = 0.95
dt[, LL := median(Means, na.rm = T) - alpha*IQR(Means, na.rm = T), by = name]
dt[, UL := median(Means, na.rm = T) + alpha*IQR(Means, na.rm = T), by = name]

dt[, res := 0 + ((df$Means < df$LL)*(-1)) + ((df$Means > df$UL)*1)]


supporting the whitewashing of a business model (monetising data/corporate surveillance) that is directly responsible for the dragnet government surveillance that we’ve been alerted to by Edward Snowden? Corporations like Facebook, Google, and Microsoft are painting themselves as the victims when they are every bit the perpetrators and it appears that some of us are buying into their story hook, line, and sinker. (9 minute read.)

22 Feb, 2014Let’s build a care.data that actually cares about your data. NHS England’s care.data programme can be implemented in a way that respects privacy and the right of people to own their own data. In this article, written in response to Ben Goldacre’s piece in The Guardian, I outline three indie data principles that any such implementation must satisfy. (5 minute read.)

31 Dec,shades for nothing and still quaff the B. & G. yellow-label benzine three times a day without experiencing a financial panic. I'll show 'em a thing or two if they attempt to rival me. And what a boat! It looks forall the world like a Florentine barn on a canal-boat."

Trust in a bottle

Can you bottle trust? The answer, it seems, is yes. Researchers have produced a potion that, when sniffed, makes people more likely to give their cash to someone to look after. A Swiss-led research team tested their creation on volunteers playing an investment game for real money. When they inhaled the nasal spray, investors were more likely to hand over money to a trustee, knowing that, although they could make a hefty profit, they could also


the potion, Fehr's team reports in Nature1. Of 29 subjects given oxytocin, 13 handed over all of their cash. Only 6 of the 29 subjects given a placebo to sniff invested all 12 of their credits.When the human trustee was replaced with a random number generator the effect disappeared. This shows, the researchers say, that oxytocin specifically boosts social interactions, rather than simply making people more willing to take risks.Business of trustKnowing more about how trust is encouraged could help with everything from business to the treatment of psychological conditions. Damping trust may be useful for people with Williams syndrome, for example, in which patients are overly friendly. "Increasing trust may be useful for people with social phobia or autism," Fehr adds.Oxytocin is "easy and cheap to producestar varies with the phase of the neutron star precession. Shakura et al. (1998) applied a model of a precessing triaxial model to pulse profiles of Her X-1 observed by *HEAO-1*, Ketsaris et al. (2000) did so for profiles observed by *RXTE*/PCA. Using all observations by *RXTE* from 1996 until 2005 we have verified that the shape of the pulse profiles is reproduced every $\sim35$ days. A careful timing analysis was performed of all archived *RXTE* data on Her X-1 and pulse profiles were generated by folding with the measured pulse periods. As an example, Fig. 3-left shows a set of pulse profiles (PCA, 9–13keV) for eight different 35d phases. The variation of the pulse shape is evident. This systematic analysis has lead to the development of the “Two-Clocks-Model” (Staubert


et al., 2009) and the successful modeling of the observed pulse profiles by a model of point- and ring-like emission from the polar caps of a neutron star with an offset-dipole field under the assumption of free precession (Postnov, 2004).

We have then started a model-independent investigation of the periodic pulse profile variations by constructing a template of those variations for the Her X-1 “Main-On” for photon energies 9–13keV. A set of observations were selected, providing a good coverage of the 35d phase range -0.05 to 0.15. This template contains flux normalized pulse profiles for every 0.01 in phase. Any 9–13keV pulse profile observed during a Main-On can then be compared to this template and the 35d phase can be determined (by $\chi^{2}_\mathrm{min}$ minimization). For the *RXTE* data we findis at least one observed pulse profile (for most Main-Ons there are several profiles). The “pulse profile phase-zero” is defined and calibrated using those cycles which were used to construct the template: for cycles 313 and 323 both times of “phase-zero” are identical (by definition). For any other cycle “pulse profile phase-zero” is found by determining the 35d phases of all available profiles by comparison with the template and a subsequent linear extrapolation to phase zero using the fixed period of 34.85d (see Fig. 5-left of Staubert et al., 2011). Using pulse profiles of other Main-On cycles of Her X-1 observed by *RXTE* over the last three decades plus one from *Ginga* and one from *INTEGRAL*, we find that these systematic variations are very stable and reproducible. The constructed template


on the basis of *Ginga* and early *RXTE* observations, proposed a model in which the changes in the shape and spectral appearance of the pulse profiles are qualitatively explained by a combination of occultation of the X-ray emitting regions by a tilted and twisted precessing inner accretion disk and changes in the accretion geometry by the changing relative orientation between disk and neutron star magnetosphere. A detailed quantitative model would be needed to verify this idea for the generation of the multi-component pulse profiles.

[99]{}

N. A., [Kuster]{} M., [Postnov]{} K. A., [Shakura]{} N. I., [Staubert]{} R., [Willms]{} J. 2000, in *Proc. “Hot Points in Astrophysics”*, Joint. Inst. for Nucl Res., Dubna, p.192 D., [Shakura]{} N. I., [Postnov]{} K. A., [Staubert]{} R., [Willms]{} J., [Ketsaris]{} N. A. 2006, *Astron. Lett.* **32**, 804 B. 2007, *Astroph.&Space Sc.*,than the entry of summary judgment, a party may petition for a peremptory writ, and would specify time limits for seeking review." (Italics added; Stats. 1983, ch. 490.)
The construction of section 437c, subdivision (l), as creating a mandatory time limit is further supported by the March 7, 1983, staff report of the Assembly Committee on the Judiciary. That report, at page 3, notes that Assembly Bill No. 350 codifies existing law insofar as it authorizes writ review of orders denying summary judgment, "... but also imposes a statutory limit for seeking the writ of mandate." The report goes on to note that the reason for such a time limit is to prevent the losing party from causing delays in trial court proceedings by use of dilatory petitions to


important to reduce leakage currents that may adversely affect the charge collected on photodiodes. This leakage current to photodiodes may manifest as dark-current or as a coupling between adjacent pixels.
Isolation regions may be formed in different ways. For example, shallow trench isolation (STI) regions have been used, doped regions have been used, and a Local Oxidation of Silicon (LOCOS) process has been used. Each of these isolation types may have benefits and disadvantages. For example, a common problem associated with the formation of STI regions is that, when ions are implanted in the substrate close to the bottom and edges or sidewalls of the trench, current leakage can occur at the junction between the active device regions and the trench resulting in “hot pixels,” (i.e., pixels that may= new XXDataContext(connStr))
        {
            ...
        }
    }

    public void WriteSomething(string text)
    {
        using (XXDataContext context = new XXDataContext(connStr))
        {
            ...
        }
    }

opposed to having this using() only in constructor and having the context as a private member variable available to every function call.
With keeping the functionality of creating a new DataContext with every function call, is it possible to