---
author:
- 'S. G. Patiri'
- 'J. Betancort-Rijo'
- 'F. Prada'
title: Quantifying the coherent outflows of galaxies around voids in the SDSS DR7
---

Introduction
============

According to the cosmological principle, the clustering of galaxies is statistically isotropic. In actual galaxy redshift surveys, anisotropies arise because distances to galaxies are obtained from redshifts (i.e. Hubble flow plus peculiar velocities), making the line-of-sight a preferred direction. These so-called redshift-space distortions (RSD) pose a problem to several large-scale structure (LSS) studies, especially those that rely on the 3-d positions of galaxies (see @Hamilton98 for a comprehensive review of the effect). Yet, RSD provide valuable information about cosmological parameters, in particular the matter density parameter $\Omega_{m}$ and the normalization of the amplitude of density fluctuations $\sigma_{8}$ (e.g. @Kaiser87 [@Cole94; @Tinker06; @Percival08; @Ross11]). The RSD studies have improved considerably sincecosmological parameters. As mentioned above, we developed a modified version of the widely used $<|{\rm cos}~\theta|>$ statistical test.

The standard way to construct a $<|{\rm cos}~\theta|>$ test would be to simply calculate the average of $|{\rm cos}~\theta|$ over all galaxies in the sample located in the relevant shells of a given width around the edges of the voids. However, because of the correlations between the galaxies within a shell of a given void, the corresponding cosine values are not independent random variables. This hinders assessing the statistical significance of the test. For instance, those correlations may cause the $rms$ to increase considerably from the standard $1/\sqrt{12N_{g}}$ $rms$ (where $N_{g}$ is the total number of galaxies in the void shells) obtained if galaxies were uncorrelated.

We constructed a modified version of


International Excellence UAM+CSIC.

Funding for the SDSS and SDSS-II has been provided by the Alfred P. Sloan Foundation, the Participating Institutions, the National Science Foundation, the U.S. Department of Energy, the National Aeronautics and Space Administration, the Japanese Monbukagakusho, the Max Planck Society, and the Higher Education Funding Council for England. The SDSS Web Site is http://www.sdss.org/.

The SDSS is managed by the Astrophysical Research Consortium for the Participating Institutions. The Participating Institutions are the American Museum of Natural History, Astrophysical Institute Potsdam, University of Basel, University of Cambridge, Case Western Reserve University, University of Chicago, Drexel University, Fermilab, the Institute for Advanced Study, the Japan Participation Group, Johns Hopkins University, the Joint Institute for Nuclear Astrophysics, the Kavli Institute for Particle Astrophysics and Cosmology, the Korean Scientist Group, theBarbachano International Honors Jorge Roldan on his 20th Anniversary

Barbachano International, Inc. (BIP), the premier leader of human capital solutions in Mexico, Latin America, and the United States, honored its longest-serving employee Jorge Roldan, who celebrated his 20th anniversary with the company on January 18. The milestone was commemorated with a luncheon where Mr. Roldan was praised by his peers who remembered and shared many special moments and achievements.

Mr. Roldan joined BIP in 1999, at the age of 24. 20 years later, Mr. Roldan is still with the company. His first job was as executive search consultant, then recruiting manager and later recruiting director, before being promoted in 2006 to vice president, his current position.

“These past 20 years at BIP have been a great life experience and very rewarding,”


The Queen and Prince Philip will officially open the new £294 million, 31-mile route on September 9, the day she passes the record set by Queen Victoria.

Victoria reigned for 23,226 days, 16 hours and 23 minutes, taking into account 63 years, 15 leap days and the precise timings of her accession and death.

The Queen will mark the milestone by travelling on a train, with First Minister Nicola Sturgeon, drawn by the steam locomotive Union of South Africa from Waverley Station in Edinburgh, stopping off at Newtongrange in Midlothian before carrying on to the final stop at Tweedbank.

The new railway will transform tourism opportunities in Scotland

Services on the new line, which will re-establish services closed in 1969, will impact on house prices along the route from Waverley to Tweedbankdecorative ornaments and may often be provided with a mechanism to cause the decorative ornament to move as the music drum rotates. The decorative ornament is usually mounted on a support member, which is associated with the drive mechanism to provide the movement to the decorative ornament.
In order to provide reciprocating movement or rotational movement to different decorative objects of the ornamental display assembly, it is known to use an output shaft of the music drum to provide the power source for the reciprocating movement of a decorative element and to make use of the unwinding phenomenon of spring to provide the rotational movement for a separate decorative ornament. When this concept is applied to a variety of movements of the decorative elements, separate drive mechanisms are required


73 is divided by x.
16
Let z(h) = -17*h - 33. What is the remainder when z(-4) is divided by 23?
12
Suppose 44*j + 3*h = 39*j + 613, -j + h + 121 = 0. What is the remainder when j is divided by 22?
12
Suppose 3*d - 311 + 59 = 0. Let u(f) = -f**3 + 8*f**2 - 15*f + 73. What is the remainder when d is divided by u(7)?
16
What is the remainder when 58 is divided by (0 + (-16)/20)*(-6 + -29)?
2
Suppose 4 = -4*z, -c - c + 38 = -4*z. Suppose -117 + 17 = -25*r. Calculate the remainder when c is divided by r.
1
Let n be 172/14 + (-14)/49. Let b(u) = -u**2 + 14*u - 2. What is the remainder when 85is divided by b(n)?
19
Suppose 45*n - 1010 = 40*n. Calculate the remainder when n is divided by 30.
22
Let n be (-2)/5 + (-17)/(-5). Let j = n - 0. Suppose 9 = j*v - 105. What is the remainder when v is divided by 20?
18
Let m(p) = -p**2 + 9*p - 7. Let q(x) = -2*x - 2. Let h be q(-4). Suppose -20*y + 473 = -9*y. What is the remainder when y is divided by m(h)?
10
Let s = 154 + -78. Suppose 0 = 9*j - s + 22. Suppose 0*y + 32 = 2*y. Calculate the remainder when y is divided by j.
4
Let g(c) = c**2 + 4*c - 8. Let s(d) = d**2 - 2 - 1 - 5 + 3*d. Let i(h) =


found in [@lm] that supersymmetry with non-minimal flavour violation in the down sector, as an example of RH current contribution ($C_7^{eff\prime}\neq0$) do not deviate much from the SM region (Fig.1). Indeed, beyond the supersymmetric case, picking up some extreme but allowed values of $C_7^{eff\prime}$ one finds that it is hard to go down more than a 10% with respect to the SM band. The other scenario, the flipped sign solution for $C_7^{eff}$ deviate more substantially[@km] (see Fig.1) from the SM region and in the direction of the measured valued.

-   $
    A_{\rm FB}(s)=\frac{3}{2}\frac{\Re(\apl\appl^*) - \Re(\apr\appr^*)}
        {|\al|^2 + |\ap|^2 + |\app|^2}
     $ [@fm; @afbsm]. The forward-backward asymmetry, is particularly interesting on its zero, wheremain source of uncertainties in QCDF comes from IR divergences originating from:

$\bullet$ Hard spectator-scattering: Hard gluons exchange between spectator quark and the outgoing energetic meson gives rise to integrals of the following type (see [@BN] for definitions): $$\begin{aligned}
   H_i(M_1M_2)
   &=& C
   \int_0^1\!dx \int_0^1\!dy \left[
   \frac{\Phi_{M_2}(x)\Phi_{M_1}(y)}{\bar x\bar y}\right.\cr
   &+& \left. r_\chi^{M_1}\,\frac{\Phi_{M_2}(x)\Phi_{m_1}(y)}{x\bar y} \right], \nonumber\end{aligned}$$ where the second term (formally of order $\Lambda/m_b$) diverges when $y\to 1$.

$\bullet$ Weak annihilation: These type of diagrams also exhibit endpoint IR divergences as it is explicit in the corresponding integrals: $$\begin{aligned}
 A_1^i =
\pi\alpha_s \!\!\!\!\!\!\!\!\!&&\int_0^1 dx dy\,
    \left\{  \Phi_{M_2}(x)\,\Phi_{M_1}(y)
    \left[ \frac{1}{y(1-x\bar y)} \right. \right.
     \nonumber \cr &+& \left. \left.
    \frac{1}{\bar x^2


allows to identify an IR safe quantity [**at this order**]{}, defined by $\Delta=T-P$ that can be evaluated safely in QCDF and that will be taken as the main input from QCDF. Another important remark is that this quantity can be directly related to observables leading to a set of sum rules that can be translated into predictions for the UT angles[@dmv2; @acta; @alp] (see Strategy 2 in Sec.3.1). In [@dmv2] this idea was extended to vector-vector final states. In this case, there is a $\Delta$ associated to each helicity amplitude. But we focus on the leading (in a naive power counting in $\Lambda/m_b$) longitudinal one. We obtain for the longitudinal $\Delta$ of the $B_d\to K^{*0}\bar{K}^{*0}$ ($B_s\to K^{*0}\bar{K}^{*0}$) decay denoted by $\Delta^{d}_{K^*K^*}$ ($\Delta^{s}_{K^*K^*}$)[@dmv2]: $$\begin{aligned}
|\Delta^d_{K^*K^*}|&\!=\!&A_{K^*K^*}^{d,0} \frac{C_F \alpha_s}{4\pi N_c}C_1\,|\bar{G}_{K^*}(s_c)-\bar{G}_{K^*}(0)|\nonumber\\&\!=\!&(1.85 \pm 0.79)\timesMembers of the genus Lampropeltis these popular and colorful kingsnake subspecies are found in the new world as far north as Canada and as far south as Venezuela. Found in a variety of habitats milk snakes have been captive bred commercially since the 1980s and come in a variety of sizes and colors, both natural and man made.

Here you may post messages or questions pertaining to all aspects and issues regarding the keeping, breeding, health, and conservation of all Milk Snakes.

If you are a new user to this forum, please take the time to review the rules first before posting: Terms of Service.

Index of /ssi/classifieds

This forum is for informational purposes only and is moderated. We ask that you refrain
from making personal attacks against individuals or companies. Anything considered
disruptive,


Internet connected Tenants require
translation from NVO3 encapsulation to IP in the NVO3 gateway. The
translation function SHOULD minimize provisioning touches.
3.4.1.2. Inter-DC GW
Inter-DC connectivity MAY be required to provide support for
features like disaster prevention or compute load re-distribution.
This MAY be provided via a set of gateways interconnected through a
WAN. This type of connectivity MAY be provided either through
extension of the NVO3 tunneling domain or via VPN GWs.
3.4.1.3. Intra-DC gateways
Even within one DC there may be End Devices that do not support NVO3
encapsulation, for example bare metal servers, hardware appliances
and storage. A gateway device, e.g. a ToR switch, is required to
translate the NVO3 to Ethernet VLAN encapsulation.
3.4.2. Path optimality between NVEs and Gateways
Within an NVO3 overlay, a default assumption is that NVO3 traffic
will be equally load-balanced across the underlying network
consisting ofoption

Okay, obviously I could just write a separate shell script that finds the correct interpreter and runs the python script using whatever interpreter it found. I'd just find it a hassle to distribute two files where one should suffice as long as it's run with the most up-to-date python 2 interpreter installed. Asking people to invoke the interpreter explicitly (e.g., $ python2.5 script.py) is not an option. Relying on the user's PATH being set up a certain way is also not an option.
Edit:
Version checking within the Python script is not going to work since I'm using the "with" statement which exists as of Python 2.6 (and can be used in 2.5 with from __future__ import with_statement). This causes the script to fail immediately with a user-unfriendly SyntaxError, and


periods of substantial budget surpluses and significant reduction of the debt. From 1817 to 1821 the national debt fell by 29 percent; from 1823 to 1836 it was eliminated (Jackson’s efforts); from 1852 to 1857 it fell by 59 percent, from 1867 to 1873 by 27 percent, from 1880 to 1893 by more than 50 percent, and from 1920 to 1930 by about a third. (Thayer 1996) The United States has also experienced six periods of depression. The depressions began in 1819, 1837, 1857, 1873, 1893, and 1929.

This all to support the Modern Monetary Theory theory that government creates money through deficit spending (spending creates money, taxing destroys it), and that a growing economy requires more money — hence more deficit spending by government. (Whether those deficits areUnderstanding how to write testable code is one of the biggest frustrations I had when I finished school and started working at my first real-world job.

Today, while working on a chapter in solidbook.io, breaking down some code and picking apart everything wrong with it, I realized that several principles govern how I write code to be testable.

In this article, I want to present you with a straightforward methodology you can apply to both front-end and back-end code for how to write testable code.

Prerequisite readings

You may want to read the following pieces beforehand. 😇

Dependencies are relationships

You may already know this, but the first thing to understand is that when we import or even mention the name of another class, function, or variable from one class (let's call this the


source class), whatever was mentioned becomes a dependency to the source class .

In the dependency inversion & injection article, we looked at an example of a UserController that needed access to a UserRepo to get all users.

controllers/userController.ts

import { UserRepo } from '../repos' class UserController { private userRepo : UserRepo ; constructor ( ) { this . userRepo = new UserRepo ( ) ; } async handleGetUsers ( req , res ) : Promise < void > { const users = await this . userRepo . getUsers ( ) ; return res . status ( 200 ) . json ( { users } ) ; } }

The problem with this approach was that when we do this, we create a hard source-code dependency.

The relationship looks like the following:

This meansIProfileService } from "./services" ; import { IProfileData } from "./models" ; interface ProfileContainerProps { profileService : IProfileService ; } interface ProfileContainerState { profileData : IProfileData | { } ; } export class ProfileContainer extends React . Component < ProfileContainerProps , ProfileContainerState > { constructor ( props : ProfileContainerProps ) { super ( props ) ; this . state = { profileData : { } } ; } async componentDidMount ( ) { try { const profileData : IProfileData = await this . props . profileService . getProfile ( ) ; this . setState ( { ... this . state , profileData } ) ; } catch ( err ) { alert ( "Ooops" ) ; } } render ( ) { return < div > Im a


       );

        /**
         * This function will use an integer bitmask (as created by toBitmask())
         * to populate the class vaiable
         * $this->permissions with the users permissions as boolean values.
         * @param int $bitmask an integer representation of the users permisions.
         * This integer is created by toBitmask();
         *
         * @return an associatve array with the users permissions.
 first need to know how binary numbers work. After that you should check out the manual entries on bitwise operators and make sure you know how a bitwise AND, OR and left/right shift works.
A bit field is nothing more than an integer value. Let's assume our bit field's size is fixed and only one byte. Computers work with binary numbers, so if the value of our number is 29, you'll actually find 0001 1101 in the memory.
Using bitwise AND (&) and bitwise OR (|) you can read out and set each bit of the number individually. They both take two integers as input and perform an AND/OR on each bit individually.
To read out the very first bit of your number, you could do something like this:
  0001


it's probably ok, but for anything else you really don't need them.
The class you posted looks a bit special to me. For example, things like ... ? true : false are veery bad practice. If you want to use bit fields, you're probably better off defining some constants and use the method described above. It's not hard to come up with a simple class.
define('PERM_READ', 0);
define('PERM_WRITE', 1);

class BitField {
    private $value;

    public function __construct($value=0) {
        $this->value = $value;
    }

    public function getValue() {
        return $this->value;
    }

    public function get($n) {
       return ($this->value & (1 << $n)) != 0;
    }

    public function set($n, $new=true) {
        $this->value = ($this->value & ~(1 << $n)) | ($new << $n);
    }
    public function clear($n) {
        $this->set($n, false);
    }
}

$bf = new BitField($user->permissions);

if ($bf->get(PERM_READ)) {
    // can read
}

$bf->set(PERM_WRITE, true);
$user->permissions = $bf->getValue();
$user->save();

I didn't try any piece of code of this answer, but it should get you started even if it isn't working out of the box.
Note that you're limited to 32 values per bit field.

A:

Here's how to define bitmasks.
// the first mask.  In binary, it's 00000001
define('BITWISE_MASK_1', 1 << 0); // 1 <<


permanent damage of lung tissue, reducing the benefits of breathing cleaner air, Schikowski suggests.

"The strength of the Swiss study is that the population is large, and standardized spirometric and air pollution data are available," says Norbert Berend, an emeritus professor and director of Respiratory Research at the George Institute of Global Health, University of Sydney, Australia. The authors' speculation that systemic inflammation due to obesity may prevent the beneficial effects of reduced pollution "has important implications and needs to be followed up with further studies," Berend notes.
argument about something but not sure where it was going yet.

“You or I don’t know where he went, that is between him and God and you don’t know what happened between them, even to the end” I knew this was leading to an argument as he was getting louder and into my face a bit more. “You need to be more concerned where you are going when you die. If your brother went to Heaven, then you better be sure you are or you will never see him again, Are you Catholic”

He smiled, and said he was born Catholic and that it is the only church and there is no way I can stand out here and know what the Bible says because you must be told by


rotação abaixo que tem o intuito de alterar o valor da posição dos pontos na curva de bezier e redesenhar essa curva no canvas posteriormente.
function runPointsAndChange(curveName, callback_1, callback_2) {
    if (all_curves[curveName] != null) {
        all_curves[curveName].forEach(function(points, index, array) {
            points.forEach(function(point, position, arr) {
                if (position % 2 === 0) {
                    points[position] = callback_1(points[position], points[position + 1]);
                } else {
goat horse horse horse

is another.  There are eight "slots", and for each slot, we can choose one of four animals.
$8^4$ seems to be the above case with the numbers ($8$ and $4$) misplaced.

The first bullet point overcounts because we're counting selections of the same animals multiple times.

The stars and bars method works fine, e.g. $$\star \star | \ | \star \star \star \star \star | \star$$ corresponds to "2 goats, 0 sheep; 5 cows; 1 horse", and we don't account for whether or not we choose goats before cows, etc.


atomic ensemble in a cavity [@simon07c] to store only the mode $|\phi_1\rangle$, heralded by the absence of a click at the cavity output, followed by retrieval, which can be shaped into any desired mode [@gorshkov07b]. *Photon subtraction.*—To demonstrate the versatility of the developed theory, we now apply it to the Rydberg-based single-photon subtractor proposed in Ref. [@honer11], showing that this scheme also yields impure output states. The detailed physics of such a setting [@supp] is complementary to the single-photon source in so far as the density matrix of the remaining photons is obtained by tracing out the first one. Since the timing of the absorption carries information about the remaining photons, the density matrix of the latter is impure as well. In fact, the single-photon subtractor and the single-photon" + city + ", " + district + ", " + province;
}
else if (!string.IsNullOrEmpty(address) && !string.IsNullOrEmpty(city) && !string.IsNullOrEmpty(district))
{
    fullAddress = address + ", " + city + ", " + district;
}
else if (!string.IsNullOrEmpty(address) && !string.IsNullOrEmpty(city) && !string.IsNullOrEmpty(province))
{
    fullAddress = address + ", " + city + ", " + province;
}
else if (!string.IsNullOrEmpty(address) && !string.IsNullOrEmpty(district) && !string.IsNullOrEmpty(province))
{
    fullAddress = address + ", " + district + ", " + province;
}
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{
    fullAddress = city + ", " + district + ", " + province;
}
else if (!string.IsNullOrEmpty(address) && !string.IsNullOrEmpty(city))
{
    fullAddress = address + ", " + city;
}
else if (!string.IsNullOrEmpty(address) && !string.IsNullOrEmpty(province))
{
    fullAddress = address + ",


token
moc_analyser.cpp:92:39: error: expected primary-expression before '>' token
         if (*reinterpret_cast<_t *>(func) == static_cast<_t>(&analyser::show)) {
                                   ^
moc_analyser.cpp:92:62: error: '_t' does not name a type; did you mean '_o'?
         if (*reinterpret_cast<_t *>(func) == static_cast<_t>(&analyser::show)) {
                                               [Ambrosius Arnoldus Guilielmus Guye, editor-in-chief of the Dutch Journal of Medicine 1884-1889].
Ambrosius Arnoldus Guilielmus Guye (1839-1905) was the patriarch of otorhinolaryngology in The Netherlands. He designed various small surgical instruments and identified the disorder aprosexia, which brought him international recognition. He can be looked upon as a second-generation hygienist. During his brief period as editor-in-chief of The Nederlandsch Tijdschrift voor Geneeskunde (Dutch Journal of Medicine) (1884-1889), he introduced a more stable production process.


Consequently, a reliable, convenient and non-invasive technology which can identify subjects at risk of DKD may add value to these detection and preventive strategies.

SUDOSCAN (Impeto Medical, Paris, France) is a novel technology that provides precise evaluation of sudomotor function through reverse iontophoresis and chronoamperometry. The technology enables measurement of electrochemical skin conductance based on reaction between sweat chlorides and stainless-steel electrodes when low direct-current (DC) voltage is applied \[[@pone.0134981.ref008]\]. A further advantage of the SUDOSCAN is that measurements are unaffected by ambient heat or humidity \[[@pone.0134981.ref008]\]. Sweat glands are innervated by small unmyelinated sympathetic C nerve fibers \[[@pone.0134981.ref009]\] and sudomotor dysfunction is known to occur during early stage of diabetes and pre-diabetes \[[@pone.0134981.ref010]\]. The same device with different built-in algorithms (EZSCAN) has been used to predict diabetes byevaluating early deficits in sudomotor function, and previous studies have reported association of electrochemical skin conductance with glycated hemoglobin (HbA~1c~), fasting plasma glucose and 2-hour plasma glucose during oral glucose tolerance test \[[@pone.0134981.ref011]--[@pone.0134981.ref015]\].

Since autonomic neuropathy reflects microvascular damage due to hyperglycemia and related metabolic perturbation \[[@pone.0134981.ref016]\], the severity of sudomotor dysfunction may serve as a surrogate for other microvascular complications including nephropathy. In a proof of concept case-control study involving 50 Chinese patients with type 2 diabetes with renal complication (estimated GFR \<60 ml/min/1.73m^2^ and albuminuria) and 50, without, SUDOSCAN-DKD score was highly correlated with GFR and albuminuria \[[@pone.0134981.ref017]\]. In the current study, we expanded the sample size to evaluate the clinical utility of SUDOSCAN in detecting impaired renal function and determine the score cut-point for detecting patients


as well as by self. All patients gave written informed consent and the study was approved by the Joint Chinese University of Hong Kong---New Territories East Cluster Clinical Research Ethics Committee. Declaration of Helsinki was adhered to.

SUDOSCAN {#sec004}
--------

SUDOSCAN is a patented device designed to assess sudomotor function based on reverse iontophoresis. This technology uses low DC stimulation to extract chloride ions from sweat to create a current when these electrically charged ions encounter specific electrodes. The current produced is proportional to the chloride concentration that reacts with the electrodes, which in turn reflects sweat gland function and its sympathetic innervation.

Four electrodes were placed on areas most enriched in sweat glands, namely the palmar sides of hands and plantar sides of feet. A DC current at an incremental voltageof SUDOSCAN, it can be a used in outreach programs or low resource setting as part of a CKD screening program.

Sudomotor function is a subtype of autonomic function which reflects the integrity of sympathetic nerve fibers innervating the sweat glands \[[@pone.0134981.ref010]\]. Sudomotor dysfunction in diabetes is manifested by attenuated sweat response to high ambient temperature and humidity especially in the lower peripheries \[[@pone.0134981.ref010]\]. With longstanding diabetes, chronic impairment of sudomotor function translates to reduced suppleness of skin, dryness and fissures especially in their feet. The C fibers which innervate the sweat glands are typically long, thin and poorly myelinated making them highly susceptible to damages by metabolic processes. The density of nerve fibres innervating sweat gland based on skin biopsies has been shown to correlate with measures of


(*P* = 0.026 and *P* = 0.0135, respectively; hypergeometric test), and even significant for PI3K inhibitors in comparison with either the EGFR (erlotinib) or MEK inhibitors (*P* = 0.0315 and *P* = 0.0173; hypergeometric test). Response patterns for all drug pairs can be explored in our portal (Supplementary Website S1; <https://szen95.github.io/SEABED>).

Subpopulations of differential response identifies drug combination efficacy {#Sec6}
----------------------------------------------------------------------------

Previous studies have hypothesised that the efficacy of many approved drug combinations can be explained by the independent action of single agents on different patient subpopulations with cancers driven by multiple pathways.^[@CR21]^ We hypothesised that SEABED comparisons of drug pairs would highlight subpopulations of differential response that would exhibit synergistic or independent action effects when the drugs are tested in combination. Additionally, our method enables us to explore putative biomarkers of such populations. Systematic comparison of responses betweento describe different disease states, is advantageous. Consequently, because of their success in other industries^[@CR48],[@CR49]^ as well as fast, efficient implementations, spectral methods based on network models are powerful methods for discovering distinct subpopulations.^[@CR50]--[@CR52]^

SEABED builds upon previous work using network models in biomedical contexts^[@CR50],[@CR51],[@CR53]^ that explicitly partition a population of cell lines described by multiple variables into distinct subpopulations, using a "top-down" approach of recursively identifying optimal cuts for graph bisection. Similarly, while our segmentation capitalises on past progress made in spectral clustering,^[@CR54],[@CR55]^ our effort distinguishes itself from past attempts by integrating all variables into a single network model using a multivariate similarity and local and global network statistics. Deeper interpretations of embedded matrix subspaces in network models may provide further insight into the linkage between subpopulations of


efficacy of two drugs that is greater than the individual effects of each drug. Combenefit (v1.31) was used to quantify drug combination synergy by comparing the observed two-dimensional (2-D) combination dose--response surface to a modelled reference based on the Loewe model of additive combinations and the single drug dose--response curves.^[@CR57]^

For a given cell line in GDSC, the drug response was fitted with a sigmoid curve^[@CR58]^ and consecutively quantified as area under the curve (AUC) or the concentration required to reduce cell viability by half (IC~50~). GDSC contains 265 compounds tested in 1074 cell lines, while we focus on a subset of 38 drugs targeting either PI3K--AKT signalling, MAPK signalling, or microtubules, which leads to 327 experiments considered for evaluation.

Deep molecular characterisation of the cancer cell lines {#Sec11}
--------------------------------------------------------

The GDSCsummary Supplementary Table S4 Supplementary Table S5

**Publisher's note** Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

These authors contributed equally: Nirmal Keshava, Tzen S. Toh

Supplementary information
=========================

**Supplementary information** is available for this paper at 10.1038/s41540-019-0113-4.

We would like to thank Ben Sidders (AstraZeneca plc.), Jonathan Dry (AstraZeneca plc.), Francesco Iorio (Sanger Institute), Michael Schubert (EMBL-EBI), Mi Yang (RWTH Aachen), and Winston Hide (Harvard University) for useful discussions. This work is supported by funding from the NIHR Sheffield Biomedical Research Centre, Rosetrees Trust (ref: A2501), and the Academy of Medical Sciences Springboard (ref: SBF004/1052).

N.K., T.S.T., M.P.M., and D.W. contributed to the conceptualisation of the project. N.K., T.S.T., and D.W. were responsible for data curation. Formal analysis was performed by N.K., T.S.T., H.Y., B.Y., M.P.M., and


  editor->Paste();
        return;
    case wxID_SELECTALL:
        editor->SelectAll();
        return;
    case wxID_DUPLICATE:
        editor->SelectionDuplicate();
        return;
    case wxID_DELETE:
        editor->DeleteBack();
        return;
    default:
        break;
    }

    if(event.GetId() == wxID_UNDO) {
        if(editor->GetCommandsProcessor().CanUndo()) {
            editor->Undo();
          check it's not a trivial amount i.e. spans at least 2 lines
        hasSelection =
            editor->LineFromPos(editor->GetSelectionStart()) != editor->LineFromPos(editor->GetSelectionEnd());
    }
    event.Enable(hasSelection);
}

void DebuggerMenuHandler::ProcessCommandEvent(wxWindow* owner, wxCommandEvent& event)
{
    clEditor* editor = dynamic_cast<clEditor*>(owner);
    if(!editor) { return; }

    if(event.GetId() == XRCID("add_breakpoint")) { editor->AddBreakpoint(); }
    if(event.GetId() == XRCID("insert_breakpoint")) { editor->ToggleBreakpoint(); }
    if((event.GetId() == XRCID("insert_temp_breakpoint")) || (event.GetId() == XRCID("insert_disabled_breakpoint")) ||
       (event.GetId() == XRCID("insert_cond_breakpoint"))) {
        editor->AddOtherBreakpointType(event);
    }
    if(event.GetId() == XRCID("delete_breakpoint")) { editor->DelBreakpoint(); }

    if(event.GetId() == XRCID("toggle_breakpoint_enabled_status")) {


editor->ToggleBreakpointEnablement(); }

    if(event.GetId() == XRCID("ignore_breakpoint")) { editor->OnIgnoreBreakpoint(); }

    if(event.GetId() == XRCID("edit_breakpoint")) { editor->OnEditBreakpoint(); }

    if(event.GetId() == XRCID("disable_all_breakpoints")) {
        clDebugEvent event(wxEVT_DBG_UI_DISABLE_ALL_BREAKPOINTS);
        EventNotifier::Get()->ProcessEvent(event);
        ManagerST::Get()->GetBreakpointsMgr()->SetAllBreakpointsEnabledState(false);
    }

    if(event.GetId() == XRCID("enable_all_breakpoints")) {
        clDebugEvent event(wxEVT_DBG_UI_ENABLE_ALL_BREAKPOINTS);
        EventNotifier::Get()->ProcessEvent(event);
        ManagerST::Get()->GetBreakpointsMgr()->SetAllBreakpointsEnabledState(true);
    }

    if(event.GetId() == XRCID("delete_all_breakpoints")) {

        // First let the plugins do this thing
        clDebugEvent event(wxEVT_DBG_UI_DELETE_ALL_BREAKPOINTS);
     Turquoise Mountain Collection - Myanmar

The Turquoise Mountain Foundation set up a new project in Myanmar in 2015 to combine heritage led regeneration in Yangon with supporting and reviving a traditional craft industry across the country, training and employing young artisans in traditional hand made jewellery


template and write in a free form.
-->

### Environment

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  To help identify if a problem is specific to a platform, browser, or module version, information about your environment is required.
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  Run the following command in your project folder in terminal.
  Note: The result is copied to your clipboard directly.

  `npx admob-plus info --clipboard`

  Paste the output of the command in the section below.
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(paste the output of the command here)

### Steps to Reproduce

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(Write your steps here:)

1.
2.
3.

### Expected Behavior

<!--
Introduction {#s1}
============

Biological rhythms are generated, at the cellular level, by complex gene-protein interaction networks. Their molecular mechanism is characterized by regulatory feedback loops and non-linear dynamics [@pone.0069573-Novak1]. Non-linearity typically arises from Michaelis-Menten enzyme kinetics and cooperative processes. Sigmoidal responses and sharp thresholds may result from the cooperative binding of a substrate molecule to an enzyme or from post-translational modifications, such as multisite phosphorylation [@pone.0069573-Gunawardena1]--[@pone.0069573-Salazar1]. In some conditions, even a single, reversible phosphorylation can produce a step-like response [@pone.0069573-Goldbeter1]. Cooperative binding of transcription factors to various sites of a gene promoter or the formation of transcription factor multimers can account for non-linearity in gene transcription [@pone.0069573-Keller1].

Mathematical models for biological oscillators accomodate these non-linear kinetics either explicitly (using detailed reactional schemes built on mass action laws), or phenomenologically (through Michaelis-Menten


curves and to study temperature compensation in circadian systems.

The Goodwin model, however, is often criticized because of the "unrealistic" large value of the Hill coefficient . Uses and misuses of the Hill function is regularly revisited [@pone.0069573-Weiss1], [@pone.0069573-Edelstein1]. In enzyme kinetics, this coefficient is usually interpreted as the number of ligand molecules that an enzyme or a receptor can bind (in fact the number of binding sites can be shown to be the upper limit of [@pone.0069573-Weiss1], [@pone.0069573-Segel1], [@pone.0069573-Santillan1]). At the transcriptional level, Hill function can be explained by the formation of repressor protein complexes or the cooperative binding of the repressor to the gene promoter [@pone.0069573-Keller1]. All these processes rarely yield Hill coefficients higher than 3 or 4.

On the other hand, several recent papers describe molecular mechanismsthat limit-cycle oscillations can be obtained only if the Hill coefficient is larger than 8. For , the model displays damped oscillations.

The Hill function and the limit-cycle oscillations obtained by numerical integration of the Goodwin model are shown in [Fig. 2](#pone-0069573-g002){ref-type="fig"}. For the parameter values chosen (), remains always above the threshold and the oscillations are rather sinusoidal. When increases, we can make switching around , inducing relaxation oscillations [@pone.0069573-Woller1]. The period of the oscillations can be easily adjusted to a circadian value by a proper rescaling of the time-dependent parameters.

![Dynamics of Goodwin model.\
(A) Inhibitory Hill function (Eq. (4), with and ). (B) Limit cycle oscillations obtained by numerical integration of Eqs. (1)--(3) for the following parameter values (arbitrary units): , , , . The oscillation period is


of the protein.

![Multisite phosphorylation.\
Comparison of the response curve of the full system and the Hill function for (A) and (B) . The blue curve gives the steady state value of as a function of the ratio , obtained by numerical integration of Eqs. (7). The parameter values are: (), (), , , , (for ), except (for the last dephosphorylation step), , , varies from 0 to 2. For the Hill function (red curve), .](pone.0069573.g003){#pone-0069573-g003}

This result confirms that, upon appropriate assumptions, multisite phosphorylation can lead to Hill-like response curve. Note that other response curves, with more/less sharp thresholds can be obtained with other sets of parameter values (see for example the case of ultrasensitivity discussed here below), but they can not always be accurately approximated by Hill functions.which the response curve of the "zero-order ultrasensitivity" function tightly fits the Hill function. There is actually a trade-off to set between the fitting of the middle part and the fitting of the upper and lower part of the response curve ([Fig 8](#pone-0069573-g008){ref-type="fig"}). We therefore manually tuned the kinetic parameters of the zero-order ultrasensitivity module such that its response curve approximates Hill function (with given Hill coefficient), using conditions derived in [Text S1](#pone.0069573.s005){ref-type="supplementary-material"} (Section E) as an initial guess for this parameter setting ([Fig. 8](#pone-0069573-g008){ref-type="fig"}).

![Zero-order ultrasensitivity.\
Comparison of the response curve of the phosphorylation/dephosphorylation module (Eqs. (S44), equivalent to Eqs. (7) with ) and the Hill function. The parameter values are: , , , , , and . The blue curve corresponds to the steady state value of as


thresholds through "zero-order ultrasensitivity".](pone.0069573.g009){#pone-0069573-g009}

The time evolution of the model is governed by the following 7 equations:

The system defined by Eqs. (13) can generate limit-cycle oscillations, which are in reasonable agreement with the prediction of the original 3-variable model ([Fig. 10](#pone-0069573-g010){ref-type="fig"}). To obtain such quantitative agreement, we had (1) to set the system in zero-order ultrasensitivity conditions, (2) to assume that the kinetics of the phosphorylation module is much faster than the kinetics of the rest of the system, and (3) to (manually) adjust some kinetic parameters.

![Dynamics of the Goodwin model combined with a "zero-order ultrasensitivity" phosphorylation module.\
The time series have been obtained by numerical integration of Eqs. (13), with the following parameter values: , , , , , . The kinetics rates of the phosphorylation/dephosphorylation reactions are asin Fig. 8 but multiplied by a factor 100. For clarity and to facilitate the comparison with the 3-variable model, variable has been multiplied by a factor 100. In panel B, a comparison of the limit cycle obtained for the present model (blue curve) and for the original 3-variable Goodwin model (black curve) shows a reasonable agreement between the two models. The period, about 40.7 a.u., is very close the period of the original Goodwin model. In panel D, the thin curve corresponds to the steady state of the phosphorylation module (cf. Fig. 8) and the thick curve is the trajectory of the present system.](pone.0069573.g010){#pone-0069573-g010}

A few other differences with the previous model are worth mentionning. First, contrary to the case of multisite phosphorylation, one condition to obtain zero-order


produces relaxation oscillations ([Fig. 11](#pone-0069573-g011){ref-type="fig"}) and was used to reproduce phase response curves [@pone.0069573-Ruoff2] and to study temperature compensation [@pone.0069573-Ruoff3] in circadian systems.

![Dynamics of the "reset" Goodwin model.\
The time series have been obtained by numerical integration of Eqs. (14)-(16) for the following parameter values: , , , , , , and (values taken from [@pone.0069573-Ruoff3]). Oscillations have a period of about 24 a.u.](pone.0069573.g011){#pone-0069573-g011}

We seek here to find a realistic molecular mechanism that can account for these abrupt phase resettings. Intuitively, a mechanism based on bistability should explain such double threshold effect and the rapid switch between the two states of the reset function.

Bistability Arising from a Double Phosphorylation Cycle {#s2f}
-------------------------------------------------------

Bistability, defined as the coexistence of two stable steady states, is thought to constitute the central process of cellularof as a function of . (B) Bistability domain in the parameter space. The other parameter values are: , , , , , , and . The bistable domain in panel A is delimited by two saddle-node bifurcation points at and (red points). The simulations have been carried out using XPP-AUTO software [@pone.0069573-Ermentout1].](pone.0069573.g012){#pone-0069573-g012}

We then check that this bistable model can, in response to a periodic signal, reproduce the abrupt switches reminiscent of the arbitrary resetting created by the function. To do so, we examined the effect of a periodic modulation of on the bistable module ([Fig. 13](#pone-0069573-g013){ref-type="fig"}). The results confirm that if the kinetics of the bistable system is sufficiently fast the bistable module produces abrupt switches, which occur when reaches the saddle node bifurcation points.

![Effect of a


already produce ultrasensitivity, provided that the Michaelian constants are very low [@pone.0069573-Goldbeter1]. The response curve obtained in that case, however, can not be accurately approximated by a Hill kinetics. We showed that such process can nevertheless be integrated in the Goodwin model and, after adjusting some kinetic parameter values, generates limit-cycle oscillations which match reasonably well the ones obtained in the original 3-variable model.

Bistable switches provide another means to produce abrupt transition. Bistability behaviour can be induced by a double phosphorylation/dephosphorylation mechanism [@pone.0069573-Markevich1], [@pone.0069573-Ortega1], [@pone.0069573-Chickarmane1]. We have shown here that such molecular description provides a realistic mechanism consistent with the arbitrary reset function used by Ruoff et al [@pone.0069573-Ruoff2], [@pone.0069573-Ruoff3]. In this way, relaxation oscillations can be generated easily, without requiring an additional, positive, transcriptional feedback loop, orof the rest of the model (Quasi-steady state approximation conditions).

(PDF)

######

Click here for additional data file.

###### Supporting Material.

(PDF)

######

Click here for additional data file.

The authors would like to thank Geneviève Dupont, Marcelle Kaufman, and Claude Gérard for helpful discussions and comments on the manuscript.

[^1]: **Competing Interests:**The authors have declared that no competing interests exist.

[^2]: Conceived and designed the experiments: DG WAJ. Performed the experiments: DG WAJ. Analyzed the data: DG WAJ. Wrote the paper: DG WAJ.


BOA-Bank management. One BOA-Bank employee involved in the origination of mortgages in the BOAMS 2008-A collateral pool admitted that the emphasis at BOA-Bank was quantity not quality and that he was pressured to increase the number of applications he approved per week. He also admitted that he received bonuses for surpassing mortgage production goals. Another such BOA-Bank employee admitted that that she and her co-workers were instructed by her superiors that it was not their job to look for fraud and stated that her job was ‘basically to validate the loans.’ She also admitted that her superiors pressured her to process applications as quickly as possible but to keep her opinions to herself.”

To state the obvious, except to DOJ, no honest lender would permit any of these practices.she cut an outsider in on the overall fraud without their permission.

DOJ (or the state) is prosecuting Loan Officer JX for acting in response to the perverse incentives B of A’s managers inflicted on the employees in order to induce them to make and approve hundreds of thousands of fraudulent loans. Loan Officer JX had a puny position at B of A. DOJ is refusing to prosecute B of A or its officers who became wealthy by incenting and coercing employees to commit loan fraud and securities fraud. DOJ is refusing to even sue the officers civilly and recover their huge fraudulent gains. DOJ’s prosecutorial ethics have become reprehensible with regard to the systemically dangerous institutions (SDIs) and their officers.

Why Didn’t DOJ Sue B of A’s CEO for


Journal metrics from the Web of Science were analyzed as follows: impact factor; total citations; countries of the authors who cited CERM; Hirsch index (h-index); and publication types of highly cited articles. The calculation methods and definitions were the same as those previously described one \[[@B1],[@B2]\]. The h-index of six other PubMed Central journals from Korea that were added in 2012 with a title change was also calculated from Web of Science and compared with that calculated for CERM. Additionally, to compare the effect of the journal language, the total citations of the *Korean Journal of Fertility* and *Sterility* and the *Korean Journal of Reproductive Medicine*, the former titles of CERM, published from 1974 to 2010 was calculated from Web of Science. The percentage of English papers wascounted for the two former titles of CERM.

Results
=======

The number of citable and non-citable articles per year in CERM is presented in [Figure 1](#F1){ref-type="fig"}. Out of 127 articles, 118 were citable and nine non-citable. The authors\' affiliations included nine countries. Among the articles, 109 out of 127 were from Korea. The other countries of the authors were Iran, China, the Unites States, Italy, the United Kingdom, Turkey, Taiwan, and Egypt ([Figure 2](#F2){ref-type="fig"}). The proportion of articles funded out of the total number of original articles is presented in [Figure 3](#F3){ref-type="fig"}. Out of 88 original articles, 35 (39.8%) were funded. The 2013 Journal Impact Factor calculated from Web of Science was 0.971. This corresponds to the 67th ranking out of 85 journals listed in the 2013 Journal Citation Reports Obstetrics


(Rumsey); 4,121,775 (Rosenberg et al); 4,209,136 (Linden et al); and 4,366,930 (Trombetti Jr) which include both manual and motor driven means for crushing tablets. However, none of the prior art devices provide either the convenience or the integrity required to accommodate the needs of the home bound geriatric or of those required to depend on enteral feeding systems for sustenance. It is toward the realization of these later goals that the present invention is directed.of tri-colored sum-free sets is meaningful even when $H = {{\mathbb{F}}}_2^n$.

Upper Bound {#sec:ub}
===========

To prove an upper bound on the size of tri-colored sum-free sets in ${{\mathbb{F}}}_p^n$, we will introduce another closely related definition.

\[def:pms\] A [*perfectly matched sequence*]{} in an abelian group $H$ is a sequence of ordered pairs $\{(a_i,b_i)\}_{i=1}^m$ in $H^2$ such that the equation $a_i+b_i=a_j+b_k$ has no solutions with $j \neq k$. The set $T = \{ a_i+b_i \mid
i=1,\ldots,m\}$ is called the [*target set*]{} of the perfectly matched sequence.

Note that if $\{(a_i,b_i,c_i)\}$ is a tri-colored sum-free sequence of size $m$, then $\{(a_i,b_i)\}$ is a perfectly matched sequence whose target set $T = \{-c_i\}$ has $m$ elements. The following theorem therefore yields an upper bound on the size of tri-colored sum-free sequences.

\[thm:pms\] Let $L_n$ denote the linear subspace


(a'',b'',c'') = (a,b',c'')$. Thus, the three given elements of $Z(w)$ are all equal to one another, as required by the definition of a tri-colored sum-free set.

Let us now prove a lower bound on the expected cardinality of $Z(w)$ when $w$ is chosen uniformly at random from $({{\mathbb{Z}}}/ M{{\mathbb{Z}}})^{n+1}$. For a given element $(a,b,c) \in X$, the values $h_0(a,w), h_1(b,w), h_2(c,w)$ must either be equal to one another or they must form an arithmetic progression. The set $B$ contains no three elements in arithmetic progression, so the event that $h_0(a,w), h_1(b,w), h_2(c,w) \in B$ coincides with the event that there exists $\beta \in B$ such that $h_0(a,w) = h_1(b,w) = h_2(c,w) = \beta$; furthermore, if any two of $h_0(a,w), h_1(b,w), h_2(c,w)$ are equal to $\beta$, then so is theCLSM present study^d^ (*n* = 39)Persistent carriers (*n* = 18)+14+10−3nd1−4+0−4nd0Others^b^ (*n* = 21)+2+0−2nd0−19+3−10nd6^a^Results from nasal swabbing (two samplings with median time interval of 28 days) and *spa*-typing in the Tromsø 6 study in October 2007--August 2008. *S. aureus* carriage status as defined by van Belkum et al. \[[@CR4]\]^b^Includes both noncarriers and intermittent carriers^c^Results from one nasal swab sampling and *spa*-typing in the present study in 2010--2011; +, positive for *S. aureus*; −, negative for *S. aureus*^d^Confocal laser scanning microscopy (CLSM); +, positive for *S. aureus*; −, negative for *S. aureus*; nd, not determined, CLSM not performed

Fourteen different *spa*-types were found among the *S. aureus* isolates from the 39 healthy participants in this study (Additional file [1](#MOESM1){ref-type="media"}: Table S1). Twelve *spa*-types were found in one individual each, while t084 and t246 were found in two individuals


each. Six individuals had changed *spa*-types since the Tromsø 6 study (Additional file [1](#MOESM1){ref-type="media"}: Table S1).

Estimation of *S. aureus* in nasal vestibule in healthy individuals {#Sec16}
-------------------------------------------------------------------

We performed a pilot study to estimate the likelihood of detecting *S. aureus* in biopsies. From nasal swabbing of 14 healthy colleagues, we found between 0 and 1.5 × 10^4^ *S. aureus* CFU/nostril (Table [2](#Tab2){ref-type="table"}). By a rough estimate, this should correspond to approximately 0--200 *S. aureus* per biopsy surface area.Table 2Number of *S. aureus* found in nares of healthy individualsNumber of *S. aureus* CFU/nostril (*n* = 14)^a^*n* = 8*n* = 2*n* = 1*n* = 1*n* = 1*n* = 10501.5 × 10^2^5.0 × 10^2^6.0 × 10^2^1.5 × 10^4a^Results from a pilot study where we determined *S. aureus* CFU/nostril in 14 healthy colleagues from Department of Medical Biology by one nasal swab culture

Biopsies were then obtained from the 39 participants and HE staining and CLSM/immunohistochemistry (IHC) were performed. Theexamples of strain replacement or co-colonization.

Intracellular persistence of *S. aureus* in connection with infection, e.g. recurrent sinusitis, has been shown in previous studies \[[@CR15], [@CR16]\]. We confirmed intracellular *S. aureus* localization in the stratum spinosum in healthy individuals by CLSM images at multiple z-planes within the nasal tissue by using specific antibodies. We did not perform a systematic investigation of intracellular localization and it was only performed in a few randomly selected donors. *S. aureus* can live as a commensal within humans without causing overt disease, and there is considerable evidence of intracellular localization of *S. aureus* \[[@CR16], [@CR34], [@CR35]\] in neutrophils \[[@CR48]\], osteoblasts \[[@CR49]\], nasal epithelial cells \[[@CR16], [@CR50]\], and endothelial cells \[[@CR51]\]. However, we did not expect to find intracellular *S. aureus* in nasal tissue from


observed nasal secretions in most of the tissue samples from both carriers and non−/intermittent carriers. Clusters of *S. aureus* were very often localized within the nasal secretions in carriers, and especially in two of our donors. One could hypothesize that staphylococci are in a dormant state in their intraepithelial localization. In the healthy nasal vestibule, the stratum corneum is not surveilled by the dendritic cells \[[@CR52]\], which could mean that staphylococci might remain undetected by the body's immune system. In addition, nasal crust formation could be considered a natural growth medium for staphylococci, leading to colony formation under the right host conditions.

Conclusions {#Sec19}
===========

Our results suggest that *S. aureus* colonize both the upper and lower layers of the epidermis within the nasal epithelium of healthy individuals. The number ofIn a conventional wire-bound telephone network each subscriber is provided with a pair of copper wires for communication. The copper wires connect the subscriber point-to-point to a local exchange or switch and then to another subscriber. These copper wires are expensive to install and maintain. Furthermore, each pair of copper wires typically has only enough bandwidth to handle one conventional unmodulated call at a time.
Attempts have been made to enable a subscriber terminal to handle more than one call at a time across a wire-bound network. One known approach is the "call waiting" procedure. According to this procedure, in a wire-bound Public Switched Telephone Network (PSTN), when an incoming call finds a telephone busy with an ongoing call, a "door knocking signal" informs the communicating parties in the


do not carry traffic. There are several different types of control channels, such as paging channels which are used for signalling downlink from the radio base station, and access channels which are used for signalling uplink towards the radio base station. Control channels between a radio base station and a radio terminal are used by a radio terminal when the terminal is not communicating on a traffic channel, for example, when first setting up a call. Therefore, where there is a call going on via a traffic channel between a radio terminal and a radio base station, the radio terminal cannot set up a second independent call using a control channel.
Thus, while RLL terminals permit a subscriber to include a third party in an ongoing call or parkreturn false;
    if(stencilPassOp != desc.stencilPassOp)
      return false;
    if(stencilFunc != desc.stencilFunc)
      return false;
    if(depthTest != desc.depthTest)
      return false;
    if(depthMask != desc.depthMask)
      return false;
    if(stencilTest != desc.stencilTest)
      return false;
    return true;
  }

  comparisonFuncs depthFunc;
  unsigned int stencilRef;
  unsigned int stencilMask;
  stencilOps stencilFailOp;
  stencilOps stencilDepthFailOp;
  stencilOps stencilPassOp;
  comparisonFuncs stencilFunc;
  bool depthTest;
  bool depthMask;
  bool stencilTest;
};

// OGL_DepthStencilState
//
class OGL_DepthStencilState
{
public:
  bool Create(const DepthStencilDesc &desc);

  void Set() const;

  const DepthStencilDesc& GetDesc() const
  {
    return


signaling complex;(2) test STAT3 acetylation in STAT3 dimerization and resisting to inactivation/degradation;and (3) test the hypothesis that STAT3 acetylation plays a role in metastasis-related gene regulation and constitutive STAT3 acetylation is responsible for metastatic phenotype in vivo. These complimentary approaches will elucidate the role of uncontrolled STAT3 acetylation/deacetylation in causing cancer cell invasion and metasasis.Kristin Mink saw protesters confront Homeland Security Secretary Kirstjen Nielsen at a DC Mexican restaurant. She read about the owner of a Virginia restaurant owner who kicked out White House press secretary Sarah Sanders. And she heard Congresswoman Maxine Waters call on citizens to “push back” on Trump Cabinet members they encounter in their daily lives.

So when Mink, a sixth-grade teacher in the DC area, spotted Environmental Protection Agency chief Scott Pruitt at lunch on Monday, she knew she had to say something. “It wasn’t part of my conscious calculation, but I think that being aware of those [other confrontations] and having seen those probably did play into the fact that the first thing that popped into my head was, ‘Oh, here’s a public official, I have the


you out.”

EPA head Scott Pruitt was 3 tables away as I ate lunch with my child. I had to say something. This man is directly and significantly harming my child’s — and every child’s — health and future with decisions to roll back environmental regulations for the benefit of big corporations, while he uses taxpayer money to fund a lavish lifestyle. He’s corrupt, he’s a liar, he’s a climate change denier, and as a public servant, he should not be able to go out in public without hearing from the citizens he’s hurting. U.S. Environmental Protection Agency U.S. EPA Administrator Scott PruittETA: You don’t have to wait til your next Pruitt sighting to take action! Click here to help Boot Pruitt! https://www.addup.org/campaigns/boot-pruitt Posted by Kristin Mink on Monday,debt, and all college debt would be forgiven after 20 years. In addition, Clinton wants to make state and community colleges tuition-free for families earning up to $125,000; that would save the average family $9,410 per year, or $37,640 over four years, according to Martin.

, borrowers would never have to pay more than 10% of their incomes toward student debt, and all college debt would be forgiven after 20 years. In addition, Clinton wants to make state and community colleges tuition-free for families earning up to $125,000; that would save the average family $9,410 per year, or $37,640 over four years, according to Martin. President Trump would cap repayments at 12.5% of a borrower’s income and if borrowers make repayments for 15 years, he would forgive the rest


#include <ifaddrs.h>
#include <arpa/inet.h>
#include <net/if.h>

#include <string>
#include <vector>
using namespace std;

string getIPAddress()
{
    BOOL success;
    struct ifaddrs * addrs;
    const struct ifaddrs * cursor;

    success = getifaddrs(&addrs) == 0;
    if (success) {
        cursor = addrs;
        while (cursor != NULL) {
            // the second test keeps from picking up the loopback address
            if (cursor->ifa_addr->sa_family == AF_INET && (cursor->ifa_flags & IFF_LOOPBACK) == 0)
            {
    fora,” he said. “The United States maintains the sovereign right to facilitate or restrict access to our territory, in accordance with our national laws, policies, and interests, subject to our existing international obligations.”

He added that the U.S. fears supporters “seek to use the Compact and its outcomes and objectives as a long-term means of building customary international law or so-called ‘soft law’ in the area of migration.”

Veprek also asserted that “calls in the Compact to prevent all instances of intolerance against foreign nationals or to promote certain perspectives for media professionals in how they report on or characterize foreign nationals raise concerns about respect for freedom of opinion and expression and media freedom, core tenets upon which the United States was founded.”

“The Compact sets the expectation that States


people tend to be off balance in favor or more acidic foods, causing pH imbalance in the body. pH imbalance is the root of a ton of health issues, like hormone imbalance, weight gain and chronic fatigue, among (many!) others. Drinking alkalizing juice with lots of veggies offers tremendous protection from these issues.

There are as many common reasons to juice for longevity and anti-aging as there are veggies and fruits to juice with! The various nutrients in fresh juice help reduce or eliminate a wide range of health issues, including:

acne

anemia

high cholesterol

bladder infections

bronchitis

canker sores

carpal tunnel syndrome

constipation

gallstone

glaucoma

headaches

hypertension

indigestion

insomnia

kidney stones

macular degeneration

menopause

morning sickness

osteoporosis

prostate enlargement

psoriasis

ulcers

varicose veins

water retention.

Berries: Packed with Antioxidants

Juicing has anti-aging benefits that rival even the top anti-aging skin care products. If your concern is anti-aging, adding berries to your juice is aone of the few players who refused to join the action.

"I tried to stick to my beliefs as a player and as a person and I copped it and it was a tough period of my life," she said.

Lisa De Vanna was one of the few players who refused to join the strike action. ( Australian Story: Jennifer Feller )

Over the following weeks, an agreement was hammered out and the Matildas baseline salary increased to $40,000 a year, enough to allow most Matildas to earn a living from the sport.

The Matildas are now in preparation for April's Asian Cup but the players know there are steep challenges ahead.

De Vanna is cautiously positive.

"There's still a lot of hard work to do but I'm very confident that from here onwards


 if (!libvulkan) return 0;

    // Vulkan supported, set function addresses
    vkCreateInstance = reinterpret_cast<PFN_vkCreateInstance>(dlsym(libvulkan, "vkCreateInstance"));
    vkDestroyInstance = reinterpret_cast<PFN_vkDestroyInstance>(dlsym(libvulkan, "vkDestroyInstance"));
    vkEnumeratePhysicalDevices = reinterpret_cast<PFN_vkEnumeratePhysicalDevices>(dlsym(libvulkan, "vkEnumeratePhysicalDevices"));
    vkGetPhysicalDeviceFeatures =
        reinterpret_cast<PFN_vkGetPhysicalDeviceFeatures>(dlsym(libvulkan, "vkGetPhysicalDeviceFeatures"));
    vkGetPhysicalDeviceFeatures2 =
        reinterpret_cast<PFN_vkGetPhysicalDeviceFeatures2>(dlsym(libvulkan, "vkGetPhysicalDeviceFeatures2"));
    vkGetPhysicalDeviceFormatProperties =
        reinterpret_cast<PFN_vkGetPhysicalDeviceFormatProperties>(dlsym(libvulkan, "vkGetPhysicalDeviceFormatProperties"));
    vkGetPhysicalDeviceImageFormatProperties = reinterpret_cast<PFN_vkGetPhysicalDeviceImageFormatProperties>(
        dlsym(libvulkan, "vkGetPhysicalDeviceImageFormatProperties"));
    vkGetPhysicalDeviceProperties =
        reinterpret_cast<PFN_vkGetPhysicalDeviceProperties>(dlsym(libvulkan, "vkGetPhysicalDeviceProperties"));
    vkGetPhysicalDeviceQueueFamilyProperties = reinterpret_cast<PFN_vkGetPhysicalDeviceQueueFamilyProperties>(
        dlsym(libvulkan, "vkGetPhysicalDeviceQueueFamilyProperties"));
    vkGetPhysicalDeviceMemoryProperties =
  Liverpool have had a £28m offer for Mohamed Salah turned down by Roma

Roma have rejected a £28m bid from Liverpool for Mohamed Salah, Sky in Italy understand.

However, Sky sources insist the two clubs remain in talks about a deal for the Egypt international.

The 24-year-old signed for fellow Premier League side Chelsea in January 2014, but left on loan to Fiorentina in 2015, before signing permanently for Roma in a €15m transfer last summer after a loan spell at the club.

While Chelsea only paid £11m to sign Salah from Basel, Liverpool could have to pay almost triple that for the forward, who scored 15 goals in Serie A last season.

He also grabbed 11 assists in the league over the last campaign, as Roma finished second.

Liverpool's new CEO Peter Moore


GEN regulates broiler development from fertilization to slaughter is lacking. Therefore, we fed both breeder hens and broilers GEN, so broilers were regulated by GEN throughout development. The present study was conducted to determine whether dietary GEN supplementation for breeders and their offspring can affect embryonic development and improve growth performance and immune function in broiler chicks.

Results {#Sec2}
=======

Effects of GEN treatment on growth performance {#Sec3}
----------------------------------------------

The effects of GEN treatment on the growth performance of broilers are shown in Table [1](#Tab1){ref-type="table"}. The results show that GEN treatment increased (P \< 0.05) the body weight gain and induced a tendency for increased tibial width (P = 0.051) of broilers by day 21 but reduced the feed conversion ratio (P \< 0.05) and had no significant effect on feed intake. In addition, there was an increase (P \< 0.05) inliver, heart and thymus index values during the early growth of GEN-treated broilers compared with values for the control (CON) group, but there was no significant effect on other organ indices. In addition, for broilers at 42 days of age, GEN treatment tended to increase (P = 0.088) body weight gain and reduce the feed conversion ratio (P \< 0.05). In addition, the breast muscle rate and leg muscle rate of the GEN group were significantly higher than those of the CON group (P \< 0.05), and there was no significant effect on the dressing percentage (P = 0.161). However, the abdominal fat percentage decreased significantly (P \< 0.05) after GEN treatment.Table 1Effects of dietary supplementation of broiler breeder hens and their offspring with genistein on broilers' growth performance at 21 and 42 days of age.CONGENP-valueDay 21  BWG0.791 ± 0.0200.815 ± 0.0160.019  FI1.077 ± 0.0461.047 ± 0.0640.302  FCR1.37 ± 0.041.31 ± 0.060.048  TL75.26 ± 1.2076.76 ± 1.670.102  TW13.08 ± 0.6113.78 ± 0.480.051  TS267 ± 31291 ± 310.292  HI0.47 ± 0.030.55 ± 0.050.017  LI2.07 ± 0.242.45 ± 0.250.024  SI0.10 ± 0.050.08 ± 0.020.241  BI0.16 ± 0.030.15 ± 0.030.811  TI0.40 ± 0.050.53 ± 0.080.006Day 42  BWG2.80 ± 0.062.87 ± 0.070.088  FI4.74 ± 0.144.68 ± 0.150.446  FCR1.68 ± 0.031.63 ± 0.040.011  DP74.05 ± 1.4674.92 ± 1.170.161  AFP1.69 ± 0.141.45 ± 0.180.008  BMR15.25 ± 0.5916.33 ± 1.130.031  LMR21.30 ± 0.8722.22 ± 0.690.034BWG,


effects on broilers and on human health.

Materials and Methods {#Sec13}
=====================

Ethics Statement {#Sec14}
----------------

This study was carried out in strict accordance with the guidelines for the care and use of animals of China Agricultural University. All experimental procedures involving animals were approved by the Animal Care Commission of the College of Animal Science and Technology, China Agricultural University. Every effort was made to minimize animal pain, suffering, and distress and to reduce the number of animals used.

Management of animals {#Sec15}
---------------------

The experiment was performed using laying broiler breeder hens (n = 8 replicate) and offspring broilers (n = 8 replicate) housed at a commercial farm (Zhuozhou, China) under standard conditions. After a 2-week acclimation period, a total of 480 57-week-old Ross 308 laying broiler breeder hens were allocated into two treatment groups (Ab and Bb);twice with Hanks solution and fixed with 3% paraformaldehyde. The results are expressed as percentages.

Antioxidant index measurements {#Sec23}
------------------------------

Livers were homogenized with saline to make a 10% homogenate. Alkaline phosphatase and the MT levels in serum samples and the MDA levels; T-SOD, CAT and GSH-Px activities; and T-AOC of the 10% homogenate were determined using a kit (Nanjing Jiancheng Inc., China) according to the manufacture's protocol.

Next-generation sequencing (NGS) {#Sec24}
--------------------------------

Total RNA samples for sequencing were purified from 20 mg of tissue sample collected from 8 chickens (4 chickens in the CON group and 4 in the GEN treatment group) using the RNeasy Fibrous Tissue Mini messenger RNA (mRNA) extraction kit (Qiagen, Hilden, Germany) following the manufacturer's recommendations. The concentration and purity of total RNA were checked using a UV/Vis spectrophotometer (ACTGene,


there has been an acceptance by the public through use, acceptance is an accomplished fact and the statute would have no application. Such acceptance was, in fact, made by the public long before the Act of 1889 came into existence. Furthermore, this *507 Act relates to streets and roads in town plots or plans of lots and not to the situation which is presented in the instant case.
In this connection, we must refer to the refusal of the court below to open the adjudication for the reception of after-discovered evidence. Of particular importance was the proposed evidence to show that at No. 1 June Term, 1784, there was a viewers proceedings involving a "plot of road from John Canon's Mill to Jacob Bausman's Ferry opposite Pittsburgh." If thestreet, we believe the court below erroneously concluded that plaintiffs had no rights in said street by way of easement created by contract. The lots in question were never in a plan of lots. The rights of both parties to this litigation were predicated upon their respective deeds, both of which called for Water Street as an abutter. In Fidelity-Philadelphia Trust Company, Trustee v. Forster, 346 Pa. 59, 29 A. 2d 496, the Supreme Court held as settled law that "where land is conveyed as bounded by a street which is plotted on the city plan but not opened, the grantee not only takes the fee in the land bounded by the street, but by implication also acquires an easement over the bed of the unopened street, unless


Meet our Entrepreneur in Residence

What is an Entrepreneur in Residence and why does Endicott have one? Read on to meet Gary Magnant, CEO and Co-founding Partner of Triple Sharp Venture Engineering, and learn more about the role he plays in bringing biotech startup success to the Endicott campus.

What is your position here at Endicott and how did you arrive here?

A few years ago when I was the CEO of Sage Science, I realized that students at teaching colleges were not receiving the same opportunities to learn to use the latest high end scientific instrumentation as students at grant funded institutions. I reasoned that students who were trained on the most advanced tools would receive high quality internships and would have a competitive advantage when apply for jobs. ISend the URL to your client in an email. Or, you can post the URL on your website. If your client accepts the offer, you are associated with your client’s purchase.

If your client wants a different number of licenses, send them a new offer or they can change the number of licenses when they purchase the subscription.

To create a purchase offer

If you manage fewer than 100 clients, navigate to Build your business > Purchase offers.

On the Select options page, choose the purchase offer options that you need:

Partner office: If your company has multiple offices, choose the office that you want to associate this purchase offer with.

You can add partner office locations at the Microsoft Partner Network website. New office locations may require up to 24 hours after they’re


      35.3 ± 0.5         [\*\*\*](#t001fn006){ref-type="table-fn"} 0.001
   OP3 implicit time                                     37.4 ± 0.7        45.4 ± 2.1         [\*\*\*](#t001fn006){ref-type="table-fn"} 0.001
   OP4 implicit time                                     48.3 ± 1.2   OPs (OP1- OP4) were significantly (*p ≤* 0.05) reduced by 51.6%, 61.8%, 68.3% and 47.5% respectively, as well as delayed implicit time of each oscillatory potential peak were noted ([Fig 2](#pone.0192400.g002){ref-type="fig"}; [Table 1](#pone.0192400.t001){ref-type="table"}).

![Individual representative of oscillatory potentials recorded from control and diabetic *P*.*obesus*.\
**Ops were recorded in response to 3 cd.s/m^2^ flash under scotopic and photopic conditions**. The OPs have been enumerated on each trace. Control (black trace); Diabetic (grey trace). Horizontal calibration, 20 ms; vertical calibration, 20 μV.](pone.0192400.g004){#pone.0192400.g004}

As shown in [Table 3](#pone.0192400.t003){ref-type="table"}, there were no significant differences in the DR-induced amplitude reduction measured when the photopic and scotopic a-waves, b-waves and OPs were compared to each other. Similarly, when considering the scotopic response, both a-and b-waves were similarly attenuated and the same was also observed with the photopic


of *Psammomys obesus*, control 2, at 28 weeks following the onset of diabetes.

Representative traces indicating: (A) Rod responses using 0.01 cd.s/m^2^ flash. (B) Mixed response using 3 cd.s/m^2^ flash. (C) Photopic responses using 3 cd.s/m^2^ flash. (D) Photopic 30 Hz flicker response. (E) Photopic S-cone response using 0.0045cd.s/m^2^ blue flash on an orange background.

(TIF)

######

Click here for additional data file.

###### Individual presentation of retina function (electroretinograms) of *Psammomys obesus*, control 3, at 28 weeks following the onset of diabetes.

Representative traces indicating: (A) Rod responses using 0.01 cd.s/m^2^ flash. (B) Mixed response using 3 cd.s/m^2^ flash. (C) Photopic responses using 3 cd.s/m^2^ flash. (D) Photopic 30 Hz flicker response. (E) Photopic S-cone response using 0.0045cd.s/m^2^ blue flash on an orange background.

(TIF)

######

Click here for additional data file.

###### Individual presentationjudgment as a matter of law on facts that are not disputed. See id." Wightman v. Springfield Terminal Ry. Co., 100 F.3d 228, 230 (1st Cir.1996).
Cross-motions for summary judgment are no more than a claim by each side that it alone is entitled to summary judgment, and the making of such inherently contradictory claims does not constitute an agreement that if one is rejected the other is necessarily justified or that the losing party waives judicial consideration and determination whether genuine issues of material fact exist. If any such issue exists it must be disposed of by a plenary trial and not on summary judgment. See Rains v. Cascade Industries, Inc., 402 F.2d 241, 245 (3d Cir.1968). See also Redman v. Warrener, 516 F.2d 766, 768 & n.


Catalogue Compositions, to CBS, Inc. By an agreement dated September 23, 1983, CBS, Inc. assigned to CBS Catalogue Partnership, its successors, and assigns, all of the rights to the copyrights it acquired from United Artists pursuant to the December 15, 1982 Main Agreement. In August 1989, CBS Catalogue Partnership changed its name to SBK Catalogue Partnership, and thereafter SBK Catalogue Partnership changed its name to EMI Catalogue Partnership. A true and correct copy of the Confirmation of Name Change and Continuance of Ownership of Copyright Interests was recorded in the U.S. Copyright Office on August 7, 1989, in volume 2487, pages 286-88. Thus, Plaintiffs allege, EMI Catalogue, through its predecessor-in-interest Morro, acquired ownership of the copyrights in musical compositions Nos. 452 to 468 (the "EMI Compositions").[5]
In early 1980,by and filed with the Copyright Office serves to put the world on constructive notice as to the ownership of the copyright and the facts stated in the registration certificate." Saenger Org. v. Nationwide Ins. Lic. Assocs., Inc., 119 F.3d 55, 66 (1st Cir.1997). See Epoch Prod. Corp. v. Killiam Shows, *55 Inc., et al., 522 F.2d 737, 740 n. 2 (2d Cir.1975), cert. denied, 424 U.S. 955, 96 S.Ct. 1429, 47 L.Ed.2d 360 (1976) (stating that registration records the claim of ownership). LAMCO/ ACEMLA thus had constructive notice of the ownership of "Patacón Pisa`o'" by Música Unica. Furthermore, ASCAP's "chain of title from the author is presumed by reason of the registration certificate where [a party] obtained an assignment of rights prior to registration." 4[] NIMMER ON


or browsing public constituted "distribution" of work within meaning of Copyright Act). Plaintiffs have satisfied the first requirement by proving ownership. The Court will wait until the special master reviews whatever further evidence and argument the parties may submit before any conclusion regarding infringement.
IT IS SO ORDERED.
NOTES
[1]  In this Opinion & Order, the Court lays the groundwork for the soon-to-be appointed special master to recommend a position on ownership and copyright infringement for each song not specifically identified by the Court.
[2]  In support, Plaintiffs introduced documents through the declarations of Jaegerman, Gallo and Insogna. Plaintiffs have alleged that within the three years prior to the filing of the complaint in this action, Defendants have issued blanket public performance licenses to broadcasters for the compositions included inthe ACEMLA "partial catalogs", which include each of the Publishers' Compositions to broadcasters in the United States. Plaintiffs also have alleged that within the three years prior to the filing of the complaint in this action, Defendants have licensed the public performance of each of the Publishers' Compositions to broadcasters in the United States.
[3]  The Court need go no further on ownership of these musical compilations, hereafter referred to as the SPACEM compilations.
[4]  The Peermusic Plaintiffs specifically refer to the declaration of Peterson Jaegerman, which supposedly identifies the copyright chains of title for the Peermusic Compositions (Nos. 1 to 407).
[5]  The EMI Plaintiffs copyright chains of title for the EMI Compositions were included as attachments to the Insogna Declaration.
[6]  Of course, that case, along


government and a private party void ab initio unless there was `plain illegality' in the contract."); Pacific Architects, 491 F.2d at 742 (stating that rescission applies when a party has been induced to enter a contract by material misrepresentation.). Because rescission is essentially an equitable remedy, it will not ordinarily be invoked where money ... will adequately compensate a party to the contract. See 17B C.J.S. Contracts §§ 467, 476 (1999). Id. at 1345-46.
[18]  Non payment of royalties was also actionable under the 1909 Act. See, e.g., Shapiro, Bernstein & Co. v. Gabor, 266 F.Supp. 613, 614 (S.D.N.Y.1966).
[19]  The Court, however, directs the special master to inquiry into these allegations.
[20]  Defendants also try to exclude many of Plaintiffs documents from consideration, arguing that they areSimultaneous and stereoselective formation of planar and axial chiralities in enantiopure sulfinyl iron diene complexes.
[reaction: see text] Enantiopure (1Z,3E)-1-sulfinyl dienes bearing an o-dithianylphenyl group can be prepared and complexed with (bda)Fe(CO)(3) to afford the corresponding sulfinyl diene iron(0) tricarbonyl complexes. This diastereoselective complexation introduces planar and axial chirality simultaneously, with a high degree of facial selectivity as well as atropselectivity. Dynamic kinetic resolution is likely to be the origin of the atropselectivity.


a factor of 405957020?
True
Does 162 divide 32776488?
True
Is 208 a factor of 2767419408?
True
Is 67424724 a multiple of 56?
False
Is 19725884 a multiple of 20?
False
Is 3829303849 a multiple of 20279?
True
Is 47 a factor of 96902391?
True
Is 771856816 a multiple of 16?
True
Is 15 a factor of 4807470?
True
Is 212701224 a multiple of 12?
True
Does 66 divide 158995983?
False
Is 161639502 a multiple of 881?
False
Is 75 a factor of 836700213?
False
Does 61 divide 168421244?
True
Is 5 a factor of 25589400?
True
Is 536 a factor of 628225073?
False
Does 898 divide 14086380?
False
Does 31 divide 58668049?
False
Does 359 divide 95427247?
False
Does 33 divide 856868103?
False
Is 6 a factor of 116585819?
False
Does 5 divide 485917909?
False
Is 7 a factor of 726276992?
True
Does 924 divide 50334900?
True
Is 68053054 a multiple of 922?
False
Does 33 divide 206769717?
True
Is 20280840 a multiple of 176?
False
Does 54 divide 2279818141?
False
Does 21 divide 12364548?
True
Is 291328961 a multiple of 47?
False
Does 40 divide 31586960?
True
Doesbeen cleaned up.

Detailing technology

While this isn't a treatise on all of the technologies that are available to good detailing houses (those places that specialize in cleaning up and refurbishing cars so that they look like new), there are a few that we can mention, just so you can get the idea of the lengths some folks may go to sell a vehicle.

For example, detailing today includes:

Special ionizing machines that can take just about any odor out of a car. Having seen them in action at various dealerships, we know this is a true statement. So a dealer can ask his detailer to ionize the car until any trace of odor is gone.

Special chrome or aluminum restorers and sealers that not only bring bright surfaces up to new-car standards,


// Copyright 2015 Google LLC
//
// Licensed under the Apache License, Version 2.0 (the "License");
// you may not use this file except in compliance with the License.
// You may obtain a copy of the License at
//
//      http://www.apache.org/licenses/LICENSE-2.0
//
// Unless required by applicable law or agreed to in writing, software
// distributed under the License is distributed on an "AS IS" BASIS,
// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
// See the License for the specific language governing permissions and
// limitations under the License.

package bigquery

import (
	"testing"
	"time"

	"cloud.google.com/go/internal/testutil"
	"github.com/google/go-cmp/cmp"
	bq "google.golang.org/api/bigquery/v2"
)

func defaultQueryJob() *bq.Job {
	pfalse := false
	return &bq.Job{
		JobReference: &bq.JobReference{JobId: "RANDOM", ProjectId: "client-project-id"},
		Configuration: &bq.JobConfiguration{
			Query: &bq.JobConfigurationQuery{
				DestinationTable: &bq.TableReference{
					ProjectId: "client-project-id",
					DatasetId: "dataset-id",
					TableId:   "table-id",
				},
				Query: "query string",
				DefaultDataset: &bq.DatasetReference{
					ProjectId: "def-project-id",
					DatasetId: "def-dataset-id",
				},
				UseLegacySql: &pfalse,
			},
		},
	}
}

var defaultQuery = &QueryConfig{
	Q:          OR
/// IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
/// FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
/// AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
/// LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
/// OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
/// THE SOFTWARE.
///
/// @ref gtc_ulp
/// @file glm/gtc/ulp.hpp
/// @date 2011-02-21 / 2011-12-12
/// @author Christophe Riccio
///
/// @see core (dependence)
///
/// @defgroup gtc_ulp GLM_GTC_ulp
/// @ingroup gtc
///
/// @brief Allow the measurement of the accuracy of a function against a reference
/// implementation. This extension works on floating-point data and provide results
/// in ULP.
/// <glm/gtc/ulp.hpp> need to be included to use these features.
///////////////////////////////////////////////////////////////////////////////////

#pragma once

// Dependencies
#include "../detail/setup.hpp"
#include "../detail/precision.hpp"
#include "../detail/type_int.hpp"

#if(defined(GLM_MESSAGES) && !defined(GLM_EXT_INCLUDED))
#	pragma message("GLM:


at concurrent point of the experiment. The Bland-Altman analysis is depicted in Figure [2A](#F2){ref-type="fig"}. The graphical analysis shows an overall homogeneity between the two methods even at lower arterial pO~2~levels. pCO~2~measurement revealed a linear regression of r^2^= 0.95 between CDI™ and blood-gas analyzer. Bias and precision were - 0.02 kPa and 0.15 kPa, respectively. The Bland-Altman plot (Figure [2B](#F2){ref-type="fig"}) showed optimal agreement at corresponding pCO~2~values during hemodynamic variations.

######

Hemodynamic Parameters

                                   Overall        **B**~**1**~   **D**~**1**~      **D**~**2**~      and it did not need re-calibration. In contrast, the available systems for continuous blood gas monitoring require re-calibration (using in vitro laboratory gas determinations) after prolonged monitoring in the clinical setting according to the recommendations of the manufacturer. However, the issue of re-calibration was not discussed in previous studies, and it was performed at different time points \[[@B34]\].

Furthermore, because of the heparin-treated sensor, there was no need for a continuous heparinised saline flush, necessary in intra-vascular systems to maintain the patency of the circuit \[[@B1]\].The flush solution, at room temperature, contains dissolved oxygen and carbon dioxide at partial pressures similar to that of the atmosphere thus it may alter the local gas tension. As a consequence, the system may measure the blood gas variables in the flush solution,


Introduction {#Sec1}
============

Evaporation from capillary structures is encountered in many natural or technological systems and processes such as the evaporation from soils^[@CR1]^ and from fuel cells^[@CR2]^, the two-phase heat transport cooling devices used in the electronics cooling industry^[@CR3]^, evaporation-driven engines^[@CR4]^, the formation of porous coatings^[@CR5]^, the drying of porous media^[@CR6]^, and evaporation with the porous wicks used in several consumer products, such as air-fresheners and insect repellents, for dispensing volatile compounds into the air. Evaporation is also used in microfluidic devices for the exploration of phase diagrams^[@CR7]^ or the characterization of fluid properties^[@CR8]^.

In most of these examples, an accurate control of the evaporation rate and of its variation over time is essential. Consider the convective drying of porous media. A simple method to control the drying speed is tostructure design {#Sec3}
--------------------------

Two basic features of evaporation in capillary structures were exploited for the design.

### Pillar arrays in a gap radial gradient {#Sec4}

The first was a hierarchical rule. Works on evaporation of a wetting liquid in porous media^[@CR17]^ have shown that invasion of the pore space by the gas phase when capillary effects are dominant is controlled by the hierarchy in the size of the constrictions of the pore space. The constrictions refer to the narrower passages where the menisci get temporarily pinned. The gas phase preferentially invades the constriction of largest size along the liquid-gas interface. In the pillar arrays, a constriction corresponds to the narrow passage between two neighbouring pillars. Consequently, a simple idea is to act on the spatial organization of the constrictions. This is


    \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\frac{d{w}_{\theta }}{dr}$$\end{document}$ \> 0, leads to (capillary) fingering.

### Phyllotaxy-inspired capillary structures {#Sec5}

Although adjusting the radial gap gradient is a simple way of controlling the drying process, another attractive possibility would be to act on secondary capillary effects. Secondary capillary effects refer to the liquid trapped in geometrical singularities of the pore spaces, such as corners or crevices. When the gas phase crosses a constriction through a piston-like displacement, it is actually rare for the liquid to be totally expelled. A small fraction of liquid remains in the void space invaded in the bulk by the gas phase. The capillary thick films trapped along the corners of a square capillary tube^[@CR12]^,are plotted in Fig. [5](#Fig5){ref-type="fig"}. The saturation *S* is the volumetric fraction of the void space occupied by the liquid phase. Hence, *S* = *1* when a given system is full of liquid and *S* = *0* when it is full of air. The saturation is obtained by image processing. This method for determining the saturation has been validated against gravimetric measurements on similar but larger systems^[@CR22]^. As for a porous medium^[@CR23]^, different drying periods are distinguished. The curves are similar for the three systems in the very first period (VFP) when the liquid evaporates until the front is pinned on the outermost row of cylinders. As discussed in the Supplementary Information, simple modelling of the VFP confirms that the transport is by vapour diffusion between the evaporation front and the external air.Figure


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AUBURN HILLS, Mich. - The Detroit Shock announced today that due to a scheduling conflict the WNBA Eastern Conference Finals dates are being moved to Friday, September 26, 7:30 p.m., Sunday, September 28, 3:00 p.m., and Monday, September 29, 7:00 p.m. (if necessary). The series will start on the road with Game 1 in New York. Home Games 2 and 3 will be played at Eastern Michigan University's Convocation Center.

"With the season being moved back a month to accommodate the Olympics, we had some arena schedule conflicts that could not be moved," said Detroit Shock Chief Operating Officer Craig Turnbull.

Detroit Shock tickets for the Eastern Conference Finals can be purchased at The Palace Box Office, online at www.detroitshock.com , by calling 248-377-0100 or at any TicketMaster/*
 * Copyright (c) 1997, 2013, Oracle and/or its affiliates. All rights reserved.
 * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS FILE HEADER.
 *
 * This code is free software; you can redistribute it and/or modify it
 * under the terms of the GNU General Public License version 2 only, as
 * published by the Free Software Foundation.  Oracle designates this
 * particular file as subject to the "Classpath" exception as provided
 * by Oracle in the LICENSE file that accompanied this code.
 *
 * This code is distributed in the hope that it will be useful, but WITHOUT
 * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
 * FITNESS FOR A PARTICULAR PURPOSE.  See the GNU General Public License
 * version


off the blood of your newborn baby" "What is its story without woman?" "I mean, sho cooks, she cleans, she takes care of the baby..." "What else she do?" " I need the child." " No!" "Before the blood changes." "THE DENTIST" "Doctor Alan Feinstone, D.D.S." "Sadistically tortures his patients" "Snaps in reaction to plaque, cavities and his wife's adultery" "Open wide..." "Do you hear how she-- she hits the highnote... so-- so perfectly from the depths of her soul?" "She sings of love." "All love." "We're gonna lose our table." "Brook." "Please humour me." "Alan, I mean, this really doesn't seem like a good time." "Brook, it's our anniversary." "Pretty, please?" "Just enough." "We wouldn't wanna lose you." "You thought to fool me, huh?" "Only I've beenplayers, asking that they remain united at this difficult time. "You have to be more united than ever. I know you'll do just that because you've done so before", said the president. The players then went out to train under Jordi Roura.


a favourite of the stock broker Rakesh Jhunjhunwala, it fell out of favour as the company posted continuous losses. It fell from a high of Rs. 68.75 in 2010 to a low of Rs. 18.5 in 2014, with a single day drop of 10% in September 2014. It continues to trade low at less than Rs. 3.5 per share in Sep-2019.

Company structure

Suzlon is a vertically integrated wind power company. It makes and installs wind turbines, and manufactures blades, generators, panels, and towers in-house. It is integrated downstream and delivers turnkey projects through its project management and installation consultancy, and operations & maintenance services. Suzlon has offices, R&D and technology centres, manufacturing facilities and service support centres spread across the globe, with its head office in Pune, India.secretion by THP-1 monocytes required glucose in the culture medium whereas IL-1β secretion occurred in the absence of extracellular glucose. Moreover, whereas knockout of *CASP4* abrogated IL-1β secretion, it only inhibited by half the secretion of FADD following activation of the non-canonical NLRP3 inflammasome. A similar mechanism was described for IL-18. While dendritic cells from *Caspase-11*-deficient mice do not secrete IL-1β in response to the activation of the non-canonical NLRP3 inflammasome, they still secrete IL-18^[@CR49]^. However, the mechanism accounting for this IL-18 secretion is unknown. Furthermore, although LPS alone (alternative pathway) induced IL-1β secretion from primary human monocytes, it did not induce FADD secretion (Fig. [6a](#Fig6){ref-type="fig"}).Fig. 6FADD protein unconventional secretion is under the control of the NLRP3 inflammasome and occurs upon several pathways in human monocytes.**a** Canonical (nigericin, ATP,


MSU, and alum crystals) and non-canonical (enteropathogen *Escherichia coli*), but not alternative (LPS), NLRP3 inflammasome inducers activate FADD secretion in human monocytes/macrophages. *Left*: FADD secretion through canonical NLRP3 inflammasome requires K^+^ efflux, NLRP3 sensor, ASC adaptor, and CASPASE-1 molecule. Cell death, which is partially inhibited by CASPASE-1 inhibitor (Ac-YVAD-cmk), accompanies the secretion process. Ac-YVAD-cmk totally inhibited IL-1β but not FADD release, suggesting that FADD secretion might require no or little CASPASE-1 enzymatic activity. *Middle*: Non-canonical NLRP3 inflammasome requires CASPASE-4 to cleave GSDMD. Activated GSDMD forms pores in the membrane leading to cellular contents release---creating a K^+^ efflux that in turn activates the NLRP3 inflammasome---and cell death. Invalidating *CASPASE-4* decreased by half FADD release, suggesting that FADD secretion might occur through two distinct pathways. *Right*: Alternative NLRP3 inflammasome inducesSteelers and Lions.

Games 1, 2 and 3 of the World Series attracted more bets on the day of the game than any NFL matchup this past week.

Nick Bogdanovich, director of trading for William Hill U.S., said the betting on the first two games of the World Series alone may have topped the amount of money wagered on last year's entire World Series between the Chicago Cubs and Cleveland Indians.


topics in this forumYou cannot reply to topics in this forumYou cannot edit your posts in this forumYou cannot delete your posts in this forumYou cannot vote in polls in this forumYou cannot attach files in this forumYou can download files in this forumtasteless decals, alloy wheels, interior furnishings and more to come up with your own horrifying interpretation of "style".

Those less inclined to visually poison everyone within fifty feet will be pleased to know this also involves spending less money on the already expensive Paceman, kicking off at 18,970 for a 122-horsepower, 1.6-engined Cooper Paceman.

It'll get you to 62 mph in 10.4 seconds and do 47.1 mpg. Trade up to the Cooper S Paceman and you'll drop only 0.8 mpg, but also reach the same 62 mph in 2.9 seconds less.

Diesels all break past the 60 mpg mark and get you to 62 mph in anything from 9.2 to 10.8 seconds, while pumping out no more than 122 g/km of CO2. Unlike some rivals though, there's no ultra-frugal model offering


macadamia oil to keep our skin soft and supple. Upon application the face cream soaks in well, leaving my face feeling smooth and plump.

Avril Face Oil with Argan Oil 50ml - certified organic by ECOCERT This has been a favorite of mine ever since I got my hands on it, this oil is lightweight, so it does not feel greasy on your face and it is packed with organic argan oil, sunflower oil, olive oil, gold alga extract and butterfly lavender extract, the oil helps to nourish and protect your skin.

If you're ready to discover the amazing benefits of Certified Organic skincare, use code JIASHINBEAUTY10 for 10% OFF your purchase at www.icareorganics.com**promo ends this 8th July 2018.player and the inner workings of the game making process is much thinner. And, in an age in our community where people demand more knowledge, more communication...demand to know more and more, maybe I am the only person out there that sometimes wishes to occasionally know a little less.

I was classically trained as a pianist growing up, from the age of five. And, in many ways I find EVE to be like music --sometimes, I just want to sit back and listen and not have to worry or think about the complexities and technicalities of the notes on the page.

But sometimes, after you start down the road of analyzing, interpreting, and pulling apart those notes, it's hard not to be aware of them every time you hear even


other words, a high coding gain may be obtained. Therefore, the technique may be applied to the HEVC range extension.
However, as a result of analysis of a large number of RGB images, a common RGB image exhibits low correlations between color planes at high frequency areas of the color planes. In other words, due to low correlations between color planes at high frequency areas, high frequency ingredients for luma area may interfere chroma pixel prediction during an application of the ECM, thereby deteriorating compression efficiency.
TABLE 1G/BG/RTest SequenceLLLHHLHHLLLHHLHHTraffic0.9260.6340.6140.5490.9630.8370.8100.777Kimono10.948−0.1050.136−0.0080.977−0.0110.3030.045EBULupoCandlelight0.8200.8590.8690.8990.9040.9440.9290.940EBURainFruits0.9090.9720.9700.9550.8920.9710.9690.956VenueVu0.7200.8850.8530.5530.5970.8400.6040.229DucksAndLegs0.9060.227−0.090−0.1540.9630.2380.125−0.186OldTownCross0.9810.4560.2650.0250.9840.6170.4660.243ParkScene0.9190.2470.4430.1170.9720.4060.4620.126Overall0.8910.5220.5080.3670.9070.6050.5840.391
Table 1 shows results of calculating correlations between four frequency bands between color planes (G-B and G-R) by using first frames of 8 RGB experimental images currently used in the HEVC range extension and shows correlations between color planes corresponding to respective+ 4 - 1)*((-1 + 3 - 4)*(-2*z + 0*z + 3*z) - 2*z + 2*z - z) - z + 28*z + 0*z.
33*z
Expand (-2 + 0 + 1)*(3*q - q - 3*q) - 3*q + q + 0*q - 2*q + 0*q + 0*q + (2*q - 3*q + 0*q)*(-1 + 0 - 1) - q - 3*q + 3*q - 3*q - 2*q + 6*q + 6*q + 0*q - q.
4*q
Expand (-15*l + 4*l +


tear them apart.

At least that’s what the laws of physics dictate would happen.

If you were ever to fall into a black hole, you’d never be able to tell anyone what actually happened. See, nothing can travel faster than light, and since even light cannot escape a black hole, any information you send back to base camp about your experience in the black hole will never actually get there. So we will never know what truly happens when you fall into a black hole.significant fluctuation in yearly income:
North Dakota Administrative Code Section 75-02-04.1-05. Determination of net income from self-employment.
"3. Farm businesses experience significant changes in production and income over time. To the extent that information is reasonably available, the average of the most recent five years of farm operations, undertaken on a scale substantially similar to farm operations of a party to the child support proceeding, should be used to determine farm income."
The guidelines also provide that tax deductions for expenses not requiring actual payments, such as depreciation, must be added to the obligor's net income amount:
North Dakota Administrative Code Section 75-02-04.1-05. Determination of net income from self-employment.
"2. After adjusted gross income from self-employment is determined, all business expenses which may be allowed for taxation purposes, but which do not require