bxt_disable_backlight(const struct drm_connector_state *old_conn_state)
{
	struct intel_connector *connector = to_intel_connector(old_conn_state->connector);
	struct drm_i915_private *dev_priv = to_i915(connector->base.dev);
	struct intel_panel *panel = &connector->panel;
	u32 tmp, val;

	intel_panel_actually_set_backlight(old_conn_state, 0);

	tmp = I915_READ(BXT_BLC_PWM_CTL(panel->backlight.controller));
	I915_WRITE(BXT_BLC_PWM_CTL(panel->backlight.controller),
			tmp & ~BXT_BLC_PWM_ENABLE);

	if (panel->backlight.controller == 1) {
		val = I915_READ(UTIL_PIN_CTL);
		val &= ~UTIL_PIN_ENABLE;
		I915_WRITE(UTIL_PIN_CTL, val);
	}
}

static void cnp_disable_backlight(const struct drm_connector_state *old_conn_state)
{
	struct intel_connector *connector = to_intel_connector(old_conn_state->connector);
	struct drm_i915_private *dev_priv = to_i915(connector->base.dev);
	struct intel_panel *panel = &connector->panel;
	u32 tmp;

	intel_panel_actually_set_backlight(old_conn_state, 0);

	tmp = I915_READ(BXT_BLC_PWM_CTL(panel->backlight.controller));
	I915_WRITE(BXT_BLC_PWM_CTL(panel->backlight.controller),
		   tmp & ~BXT_BLC_PWM_ENABLE);
}

static void pwm_disable_backlight(const struct drm_connector_state *old_conn_state)
{
	struct intel_connector *connector = to_intel_connector(old_conn_state->connector);
	struct intel_panel *panel = &connector->panel;

	/* Disable the backlight */
	pwm_config(panel->backlight.pwm, 0, CRC_PMIC_PWM_PERIOD_NS);
	usleep_range(2000, 3000);
	pwm_disable(panel->backlight.pwm);
}

void intel_panel_disable_backlight(const struct drm_connector_state *old_conn_state)
{
	struct intel_connector *connector = to_intel_connector(old_conn_state->connector);
	struct drm_i915_private *dev_priv = to_i915(connector->base.dev);
	struct intel_panel *panel = &connector->panel;

	if (!panel->backlight.present)
		return;

	/*
	 * Do not disable backlight on the vga_switcheroo path. When switching
	 * away from i915, the other client may depend on i915 to handle the
	 * backlight. This will leave the backlight on*panel = &connector->panel;
	u32 pwm_ctl, val;

	/*
	 * CNP has the BXT implementation of backlight, but with only one
	 * controller. TODO: ICP has multiple controllers but we only use
	 * controller 0 for now.
	 */
	panel->backlight.controller = 0;

	pwm_ctl = I915_READ(BXT_BLC_PWM_CTL(panel->backlight.controller));

	panel->backlight.active_low_pwm = pwm_ctl & BXT_BLC_PWM_POLARITY;
	panel->backlight.max =
		I915_READ(BXT_BLC_PWM_FREQ(panel->backlight.controller));

	if (!panel->backlight.max)
		panel->backlight.max = get_backlight_max_vbt(connector);

	if (!panel->backlight.max)
		return -ENODEV;

	panel->backlight.min = get_backlight_min_vbt(connector);

	val = bxt_get_backlight(connector);
	val = intel_panel_compute_brightness(connector, val);
	panel->backlight.level = clamp(val, panel->backlight.min,
				       panel->backlight.max);

	panel->backlight.enabled = pwm_ctl & BXT_BLC_PWM_ENABLE;

	return 0;
}

static int pwm_setup_backlight(struct intel_connector *connector,
			       enum pipe pipe)
{
	struct drm_device *dev = connector->base.dev;
	struct intel_panel *panel = &connector->panel;
	int retval;

	/* Get the PWM chip for backlight control */
	panel->backlight.pwm = pwm_get(dev->dev, "pwm_backlight");
	if (IS_ERR(panel->backlight.pwm)) {
		DRM_ERROR("Failed to own the pwm chip\n");
		panel->backlight.pwm = NULL;
		return -ENODEV;
	}

	/*
	 * FIXME: pwm_apply_args() should be removed when switching to
	 * the atomic PWM API.
	 */
	pwm_apply_args(panel->backlight.pwm);

	retval


Q:

Testing SOQL insert operation

I have an apex class that takes a call note id, finds a related sObject record, creates and object with the ids of both, and then inserts that record into an sObject. This code works when I run it from a visualforce page or a trigger, but when I run the test class method for it, the test fails. The test works by specifying a call note id which is passed to the apex class method. The method then performs the insert operation and then back in the test method, a select statement is run along with code to determine if the records (which link call notes and records from another sObject):
 //test if the Call Note already has an associated record in thetook place in two phases: covert subversion and military intervention. "Phase one was coordinated by Kao and phase two by Manekshaw, both reporting directly to Indira Gandhi," he said. During the 1971 war, intelligence was thorough enough that the Indian Air Force could bomb the room in which the East Pakistan Cabinet was in session. Naval commandos were able to blow every single Pakistani ship in the Chittagong harbour.

Kao maintained close connection with the new nation. In May 1975, Prime Minister Indira Gandhi sent him to Dhaka to warn Sheikh Mujibur Rahman of his impending assassination by some in his Army.

Merger of Sikkim
Kao can also largely be credited for merging Sikkim into India in 1975 as its 22nd state. It was he who predicted and identified the fact


1971 war, it had become a highly efficient and formidable force. Kao is credited to have, in only three years of R&AW's existence, helped in bringing about the creation of a new nation.

Former chairman of Joint Intelligence Committee K.N. Daruwala has said:
"His contacts the world over, particularly in Asia—Afghanistan, Iran, China, you name it—were something else. He could move things with just one phone call. He was a team leader who rode out notorious inter-departmental and inter-service rivalries, which is commonplace in India."

R.N. Kao Memorial Lecture
In order to commemorate the legacy of its founder R&AW created the annual R.N. Kao Memorial Lecture. The first lecture took place in 2006 on the fifth anniversary of Kao's death, and was delivered by writer-diplomat Shashi Tharoor. In 2007 Kumar Mangalam Birlais similar, with the government having recently consulted on a number of proposed reforms to the CIL regulations, to be implemented in January 2014. These included proposals to make discount market sales housing exempt from levy charges, and to allow levy payments to be phased when planning permission is phased to assist in getting development underway. Only 45 private developers/house builders responded to the consultation.The guidance is clear; without developer input councils are in danger of implementing unviable levy rates. So why aren’t developers having their say to avoid this happening?The Planning Resource article found that developers are often disillusioned with the CIL process, considering objecting to a draft Charging Schedule to be a futile exercise. Independent examiners have readily accepted Local Authority evidence without significant modifications being


Seizures Emergencies Overview

Seizures are uncontrolled electrical activity in the brain that may lead to symptoms that may range from mild loss of attention to violent muscular contractions that can lead to death. Everyone has the potential to have seizures. Some people have them frequently. Seizure disorders vary tremendously. Some people have only an occasional seizure, and other people have daily or more frequent seizures. Another term frequently used in the place of seizure is convulsion.

There are many different types of seizures. Seizure activity may range from simple blank staring to loss of consciousness with spasticity or muscle jerking.

Generally, a seizure should be considered an emergency in these situations:

Seizures that do not stop within a few minutes.

Prolonged confusion remains after the seizure (more than 10-15 minutes).

The person is notdays , so stock up on it whenever, and wherever, you can.Friends and relatives will likely start coming out of the woodwork in your newborn’s first few weeks, and while you certainly want to show off your new addition, it’s critical that you put you and your baby's welfare first. If necessary, be a little bit selfish and say no to others' requests if you don't have the energy. When family and friends do drop by, don’t be afraid to put them to work. Ask your loved ones to bring a freshly cooked dinner each time they visit, or invite your partner’s parents over to help with some of the household chores. Regardless of how tenuous your relationship may be with your in-laws, you’re bound to see them


the Russians objected to our ballistic missile defense (BMD) plans for NATO Europe to defend against an Iranian nuclear missile threat. Now ponder why President Obama told Russian President Medvedev in the fall of 2012 that he would have "more flexibility" to deal with the BMD issue in his second term which he has now basically canceled. Coincidence?

The current world situation is presenting many complicating challenges to current and future U.S. objectives. With the Obama administration presiding over the hollowing out of our military forces and prepared to further weaken our strategic nuclear posture, our adversaries are being emboldened to challenge us in a number of areas. The Middle East is in a continued state of turmoil, with no end in sight. Iran continues to ignore U.N. sanctions        _________________________________

      *
        After examining the briefs and appellate record, this panel has determined
unanimously that oral argument would not materially assist in the determination of
this appeal. See Fed. R. App. P. 34(a)(2); 10th Cir. R. 34.1(G). The case is therefore
ordered submitted without oral argument. This order and judgment is not binding
precedent, except under the doctrines of law of the case, res judicata, and collateral
estoppel. It may be cited, however, for its persuasive value consistent with
Fed. R. App. P. 32.1 and 10th Cir. R. 32.1.
      This case involves the termination of dock license agreements on New

Mexico’s Ute Reservoir. Plaintiffs appeal from three orders of the


the patent in detail but from Apple's description my initial
suspicion is that this patent could likely be invalidated by using the prior
art of MUD clients such as Tintin from the early 90s. It was fairly common for
users to set up triggers that detect particular patterns of text that
represented structured information and then initiating an action based upon
them.

Here's Apple description of what the patent in question is:

"The '647 patent generally relates to a computer-based system and method for
detecting structures and performing computer-based actions on the detected
structures. In particular, this invention recognizes that computer data may
contain structures, for example, phone numbers, post-office addresses, and
dates, and performs related actions with that data. The '647 patent
accomplishes this by identifying the structure, associating candidate actions
to the structures, enabling selections of an action, andthe case of the
second one, probably before anyone involved at Apple or HTC was born. Doesn't
sounds very novel or inventive.

Interesting read though, maybe I should start stocking up on Androids ready
for the black market!

~~~
Geee
Just to remind you that the title of the patent isn't the patent itself.
There's many ways to do the same thing, each patent is for a particular method
or model. For example, you could claim patent for 'bicycle', and describe your
model in the patent.

~~~
petegrif
You are 50% right. The title isn't the patent - true. But the description
isn't the patent either. The description serves to demonstrate how the claims
may be implemented and hence underwrites their validity. It is the claims that
have the teeth. (Respecting the fact that in cases of ambiguity the
description will indeed be referenced)

------
vilya
If one


you cold. They are using the system as they should,
defensively and offensively. No problem with them or any other company,
really.

My problem is with the patent system and how it is granting patents for
implementation rather than invention. Implementation simply requires stating a
problem to someone skilled in the art. That person, in turn, is able to find a
solution promptly. And so could thousands of others equally skilled in the
art. Invention should have a much higher standard of proof or performance.

More importantly, large companies have the financial horse-power to accumulate
thousands and thousands of these "been there done that" patents. What this
means is that those engaged in true innovation have to walk around in fear of
running into this mine-field for the simple act of doing something that anyone
skilled in the art wouldIntroduction
============

*Diabetes mellitus*(DM) is a metabolic disorder characterized by hyperglycemia, insufficient insulin secretion, and receptor insensitivity to endogenous insulin. Its incidence is associated with high morbidity and mortality rates \[[@B1]\]. In pregnancies complicated by diabetes, hyperglycemia and alterations in lipid metabolism are associated with both maternal and fetal complications \[[@B2],[@B3]\], causing reproductive abnormalities that enhance spontaneous abortion, congenital anomalies, and neonatal morbidity and mortality \[[@B4],[@B5]\].

Congenital anomalies are more common in infants of diabetic women than in children of nondiabetic women. The etiology, pathogenesis and prevention of diabetes-induced anomalies have spurred considerable clinical and basic research efforts. The infant of the diabetic mother also has increased risk for several neonatal complications, such as macrosomia, hypoglycemia, hypocalcemia, polycythemia and hyperbilirubinemia. Up to 25% of such offspring have been reported with these


complications. It also appears that early detection and subsequent strict metabolic control of pregnant women with diabetes in pregnancy should decrease the frequency and severity of some of these short- and long-term complications in the offspring of the diabetic mother \[[@B4]\].

Despite increased clinical efforts to improve glycemic control during diabetic pregnancy, however, the rate of congenital malformations remains increased in studies of Diabetes mellitus (DM) of type 1 \[[@B6]-[@B9]\], DM type 2 \[[@B9]-[@B12]\], and gestational diabetes (GDM) \[[@B10],[@B13]\]. The prevalence of major congenital malformations is approximately three to five times higher in infants of diabetic mothers \[[@B14]-[@B17]\] and is presently the most common cause of perinatal death among these infants \[[@B18],[@B19]\]. Diabetes is associated with a variety of anomalies, primarily cardiovascular, neurological, and musculoskeletal \[[@B20]\]. The malformation consideredadult life and were mated, and 76 of these presented with a positive vaginal smear. On GD 0, only 37 female rats presented with glycemia between 120 and 300 mg/dL and were included in the STZ group; only 28 rats reached term pregnancy. In the control group, 45 female rats received citrate buffer during the neonatal period. All of the rats reached the reproductive phase and were mated. Of the 45 mated female rats, 37 were pregnant with glycemia less than to 119 mg/dL and were included in control group. On day 21 of pregnancy, 28 rats had reached term pregnancy.

3.1 Glycemia during pregnancy
-----------------------------

In control rats, normoglycemia was confirmed with mean glucose values below 119 mg/dL (day 0, 7, 14 and 21 of pregnancy). In STZ rats, a


substrate. The alterations in the maternal GH/IGF axis may lead to permanent pathological fetal programming of the IGF axis \[[@B59]\], causing late consequences of poor fetal environment reflected in intrauterine growth restriction, as confirmed by our results.

It was observed in our study that the placentas of mildly diabetic rats had a higher weight, which might represent a compensatory mechanism to assure the maternal-fetal exchanges contributing to fetal development. This justifies the similar mean fetal weights between the two groups (STZ and control). The increased weight of the placentas also contributed to increased placental index in the diabetic group. However, the increased placental weight/index was not enough to improve fetal development, as confirmed by increased rate of fetuses classified as small for gestational age.

Maternal diabetes during pregnancy is knownfrom neonatally streptozotocin-induced mild diabetic rat presented an increased frequency of abnormal sternebra and absent cervical nuclei. However, these skeletal abnormalities are not considered to be major anomalies. In other words, the alterations caused by mild diabetes were not sufficient to cause the emergence of skeletal anomalies. The number of ossification sites among the experimental groups showed that there was not somatic immaturity in the development of the fetuses of female rats with mild diabetes, showing that the glycemic intensity did not influence the studied variable. In conclusion, mild diabetes caused alterations in fetal development characterized by intrauterine growth restriction, which was evidenced by the increase of the proportions of fetuses classified as small for pregnancy age. This glycemic intensity led no major congenital defects in the fetuses


evidences the debtor's or any of his predecessors in interest express intention to dedicate the roadway, and no map or plat has been filed showing the existence of the roadway from which an intention to dedicate might be implied. Therefore, there has been no common law dedication of the roadway.
The public may also acquire a prescriptive right to use the land as a roadway if there is "actual, continuous, uninterrupted use by the [public] of the lands of another, for [the] prescribed period" of twenty years. Downing v. Bird, 100 So.2d 57, 64 (Fla.1958); Gibson v. Buice, 394 So.2d 451, 452 (Fla. 5th DCA 1981). The use must be (i) "adverse under claim of right," (ii) "inconsistent with the owner's use and enjoyment of his lands," and (iii)Downing, the debtor asserts that the County cannot satisfy the construction requirement of § 95.361. As proof that the County did not construct the road, the debtor offered the affidavit of Willie Tharp, a 78-year resident of Washington County, who swears that the road was originally a "three trail path" that was later improved and maintained by the people who lived alongside the roadway. Tharp states that the County came along much later and merely graded the already existing roadway. Tharp's affidavit remains uncontradicted.
The Objectors attempt to refute the debtor's contention by offering copies of transcripts of County Commission meetings held in 1926 and 1927, in which the Commissioners purportedly agreed to contract with one W. Gilbert to build the road across the debtor's property. Objectors presented no


employing a person, such as the apprenticeship levy

28% of accountancy, legal advice and other consultancy work

18% of plumbing, building and other skilled manual work

17% of cleaning and other household services

9% of delivery or courier services

Reuters

A spokesperson for the meal delivery service Deliveroo, one of the companies at the heart of the gig-economy debate, said: “We would welcome the opportunity to work with the government so we can end this trade off between flexibility and security.”

Mr Taylor’s report did not attack the gig economy. It said that flexibility in the workplace was important and had contributed to record high employment.

He pointed to the official Labour Force Survey of March this year, which found that 68% of those on zero hours contracts did not want more hours.

However, he said toowith long draw distances and densely packed scenery filled with buildings, spectators, and plenty of incidental detail. Courses previously available in Forza 5 also see an upgrade: Sebring features the addition of fences erected on the sides of the track, while extra vehicles are seen in the background. Artistic alterations are made to some tracks in order to open up the landscape and better realise the level of detail on offer. The Prague circuit is an interesting example, where rows of trees that overhang the road are removed in one section of the track, thus opening up the exquisite view of the historical architecture on show.

The repositioning of art assets is often joined by tweaks in other areas too. Trees appear more lifelike, while texture detail is given


mean.

September 6, 2012 at 10:49 pm |

Jack

@Just One,

You really couldn't be any more wrong. Atheists place their trust (not faith) in science. And the beauty of science is that it is self correcting. If a problem is found and inconsistencies arise, the solutions will be discovered and the inconsistencies will be smoothed out. And it is this constant self-correction that leads science closer to what people would call the truth.

Religion seems to do the opposite. It claims to know the truth and works backward.

September 6, 2012 at 10:51 pm |

Just one

No, Gadfly. I will give you a simple one. Why is the balance of matter and anti matter off? Why is the ratio of strong and weak atomic forces just right to allow for star formation?

The odds ofthis cult.

September 6, 2012 at 10:38 pm |

John Thomson

Or we just believe in science and wish that our fellow human beings would quit living in the past with folklore telling them stories that are apparently more superior than actual scientific discoveries.

September 6, 2012 at 10:52 pm |

schoolsub

I would like an atheist to explain to me how a cloud of cosmic dust was able to become a planet, with an atmosphere capable of supporting 'life', to become beings capable of growth and reproduction, to become intelligent, social beings, capable of independent thought, problem solving, high level design, communication, WITHOUT some intelligent design force. The sophistication of the life on our planet could not have simply 'evolved'. A bunch of random events involving subatomic particles simply cannot explain what exists


on our planet. For every convergent event there would be some divergent event if this glob of particles simply interacted at random. There must be an intelligent force controlling it. I choose to call this force "God".

September 6, 2012 at 10:37 pm |

adibese

Maybe read a book?

September 6, 2012 at 10:38 pm |

Gadflie

Gravity and evolution. You're welcome.
But, just for the record, God is MUCH harder to explain.

September 6, 2012 at 10:39 pm |

Amistavia

Based on your name, I really hope that you aren't responsible for teaching anyone. If you want the answer to your questions, high school level classes in biology, chemistry, and physics will provide you with ample answers.

September 6, 2012 at 10:40 pm |

bigdoggie

That's find and dandy for YOU! But, many of us don't want YOUR idea beingreasoning validates EVERY god ever created, from Apollo to Zeus. :D

September 6, 2012 at 10:45 pm |

J

Read some science books. Educate yourself.

September 6, 2012 at 10:45 pm |

John Thomson

"intelligent design force"? What are you talking about, maybe the words you are saying don't actually make any sense at all, just think about what you are saying for a little bit.

September 6, 2012 at 10:57 pm |

kc_and_fa

Atheistism sounds a bit like yet another in your face religion to me. The difference with it is that that there is no god to worship but the right to call everyone else's belief system wrong or a fantasy is common.

September 6, 2012 at 10:35 pm |

GetOffYourHighHorse

Yup. A true atheist wouldn't care whether God was inserted or not. Caring enough and wanting people


B 282, 309 (1992) M. Faizal, Mod. Phys. Lett. A27, 1250075 (2012) M. Faizal, JHEP. 1204, 017 (2012) K. Okuyama, Prog. Theor. Phys. 127, 229 (2012) M. Faizal, Europhys. Lett. 98, 31003 (2012) M. Faizal, Phys. Rev. D84, 106011 (2011) M. B. Halpern, JHEP. 1011, 031 (2010) M. Faizal, Comm. Theor. Phys. 57.4, 637 (2012) A. Pakman, JHEP. 0306, 053 (2003) M. Faizal and D. Smith, Phys. Rev. D85, 105007 (2012) P. Mansfield, Nucl. Phys. B416, 205 (1994) M. Faizal, Mod. Phys. Lett. A. arXiv:1207.2120 – Accepted B. H. LIan and G. J. Zuckerman, Comm. Math. Phys. 154, 613 (1993) M. Faizal, Comm. Theor. Phys. arXiv:1207.6564 – Accepted V. O. Rivelles, Phys. Lett. B 577, 137 (2003) M. Faizal and M. Khan, Eur. Phys. J. C 71, 1603Money Debited but ticket not booked

What happen if Money Debited but ticket not booked?

The online payment at IRCTC involves complex system of technical and telecommunication networking integration between customer’s Internet bandwidth, IT system of banks and payment gateways and is dependent on internet connectivity across
various constituents.


Street. The catering was wonderful, largely because the kitchen is in house (Duck, Duck, Mousse) and the chef is very accommodating. With 110-130 people, you could take the entire first floor and have drinks outside on the patio. Or you could spring for the whole house, which will give you the upstairs, too. They have a parking lot adjacent, whcih is a nice convenience. It'll be cozy, elegant, well decorated, but not stuffy. I was really, really impressed by the Victorian House.

While we were looking at the Victorian House, we also talked to Cafe del Rey. They have an option to rent out the restaurant, which is a nice option. It's not cheap, but you'd get a first class kitchen and waitstaff. And the view is very nice.answer a math problem or the best deck to choose in a card game, they show emotional and physical responses long before they became consciously aware of the rules or are able to articulate them.

Gut Check

This emotional response—think of a student having a "gut feeling" that a particular answer was right—was the first sign of a student learning from her experience with the task. In fact, separate studies found that people with a particular type of brain damage—to a part of the brain that connects areas associated with feeling emotions with those associated with developing cognitive strategies—do not learn from failure and continue to choose inappropriate strategies for solving a problem even if they consciously "know" the rules.

"What happens when thinking is devoid of emotion is you don't


is well known to be tolerant to alcohols. *Saccharomyces cerevisiae*is tolerant to up to 20% ethanol \[[@B6]\]. In a test of many microbial strains for butanol tolerance, baker\'s yeast *S. cerevisiae*and *Lactobacilli*were the only microbes able to grow in butanol concentrations higher than 20 g/l \[[@B7]\]. In addition, yeast is relatively robust in other respects, commonly used in fermentations with harsh conditions, and its outstanding performance in lignocellulosic hydrolysates would enable future combination of the higher alcohol production with fermentation of lignocellulosic materials. Yeast naturally produces small amounts of higher alcohols through the degradation of amino acids \[[@B8],[@B9]\], such as isobutanol among others \[[@B2],[@B3]\]. These are of great importance in the flavour profiles of beer and wine, as they generate desired fruity aromas in these products when producedconverts two molecules of pyruvate to 2-acetolactate, which is then reduced to 2,3-dihydroxyisovalerate by acetohydroxyacid reductoisomerase (Ilv5). Further, 2,3-dihydroxyisovalerate is converted to 2-ketoisovalerate by dihydroxyacid dehydratase (Ilv3). Ilv6 is the regulatory subunit of acetolactate synthase and an enhancer of Ilv2 catalytic activity. The bidirectional reaction between 2-ketoisovalerate and valine is catalysed by the branched-chain amino-acid aminotransferases (Bat1 and Bat2, present in the mitochondrial matrix and the cytosol, respectively). Finally, the 2-ketoisovalerate is converted to isobutanol by pyruvate decarboxylases (PDC) and alcohol dehydrogenases (ADH). We have here used overexpression of the valine pathway genes *ILV2, ILV3*and *ILV5*to generate a sixfold higher isobutanol yield. The finding that the isobutanol production in yeast that ferments a rich, complex medium could be increased by overexpression of Bat2 \[[@B10]\] prompted us to overexpress


of 2-ketoisovalerate in the *ILV2 ILV3 ILV5*overexpression strain might have become bottlenecks. These could include valine inhibition to Ilv2, transportation of 2-ketoisovalerate or valine from mitochondria to cytosol, and affinities of PDCs to 2-ketoisovalerate in cytosol.

![**Effects of gene overexpression on isobutanol yield in various media under aerobic conditions**. The isobutanol yields (mg per g glucose) of the reference strain (CEN.PK 113-5D) and the *ILV2 ILV3 ILV5*overexpression strains are presented with columns with different colours, and the values are shown on the top of each column. All cultivations were carried out aerobically in shake flasks in either mineral medium with 40 g glucose/l or yeast extract/peptone/dextrose (YPD) complex medium with 17 g glucose/l.](1754-6834-4-21-4){#F4}

In this study, the isobutanol production yield was increased first by simultaneously overexpression genes, *ILV2, ILV3*and *ILV5*inidentical strains, independently isolated in the last step of construction, with plasmids YDp-L_P+ILV2, YDp-W_P+ILV3, YDp-H_P+ILV5 and YDp-U_P+BAT2 were designated ILV235BAT2_XCY715 and ILV235BAT2_XCY723, respectively. The genomic integration of the plasmid was confirmed by PCR amplifying PGK1+ILV2, PGK1+ILV3, PGK1+ILV5, PGK1+ILV6 or PGK1+BAT2 fragment from the genomic DNA of the constructed overexpression strains.

Quantitative real-time PCR
--------------------------

Quantitative real-time PCR was used for quantifying the copy number of the integrated gene and its transcriptional level in the overexpression strain.

Total genomic DNA isolation
---------------------------

The overexpression strains and the reference strain were cultivated with shaking in 10 ml YPD medium at 30°C overnight. The cells were harvested and lysed with 0.5 mm acid-washed glass beads in 200 μl of breaking buffer through 3 min of vortexing. The breaking buffer contained 2% Triton X-100, 1% SDS, 100 mM


pH was maintained at 5.0 by automatic addition of 2 N NaOH. The CO~2~and O~2~concentrations in the effluent gas from the fermenter were analysed by gas monitor (Innova 1311, Innova Airtech Instruments, Denmark). Samples were taken throughout the cultivation for optical density measurement, biomass dry weight determination, and high-performance liquid chromatography (HPLC) analysis. Samples for GC analysis were taken when glucose was depleted (defined by the zero value of CO~2~in the effluent gas).

Analytical methods
------------------

Optical density was measured at 600 nm with a Shimadzu UV-Mini 1240 spectrophotometer, (Shimadzu Scientific Instruments, Kyoto, Japan). Dry weight of biomass was determined gravimetrically by filtration of a known volume of culture over a predried and weighed 0.45 μm-pore-size filter. The filter with biomass was rinsed with a twofold volume of 0.9% NaCl, dried\le\,\|\chi f^{-1}\|_{\alpha,I}(\|\eta_1\|_{1+\alpha,I}+\|\eta_2\|_{1+\alpha,I})\|\eta_1-\eta_2\|_{1+\alpha,I} \\[0.3cm]
  \hspace*{1.2cm}\displaystyle
    +\,\|\chi f^{-1}\|_{\alpha,I}\|\eta_1\|_{\alpha,I}\|\eta_1-\eta_2\|_{2+\alpha,I}
    +\|\chi f^{-1}\|_{\alpha,I}\|\eta_2\|_{2+\alpha,I}\|\eta_1-\eta_2\|_{\alpha,I} \\[0.3cm]
  \hspace*{1.2cm}\displaystyle
    +\,\|\chi'^2\chi^{-1}f^{-1}-\chi''f^{-1}\|_{\alpha,I}(\|\eta_1\|_{\alpha,I}+\|\eta_2\|_{\alpha,I})
     \|\eta_1-\eta_2\|_{\alpha,I}\,.
\end{array}$$ Note that $$\label{2.16}
\begin{array}{lll}
  \|\eta\|_{\alpha,I}\negthickspace
  & \le & \negthickspace\displaystyle
          \|\eta\|_{0,I}
          +\max_{\genfrac{}{}{0pt}{1}{x_1,x_2\in I}{x_1\not=x_2}}
           \frac{|\eta(x_1)-\eta(x_2)|}{|x_1-x_2|}\,|I|^{1-\alpha} \\[0.7cm]
  & \le & \negthickspace\displaystyle
          \|\eta\|_{0,I}
          +|I|^{1-\alpha}\max_{\genfrac{}{}{0pt}{1}{x_1,x_2\in I}{x_1\not=x_2}}
           \max_{\xi\in[x_1,x_2]}|\eta'(\xi)| \\[0.7cm]
  & \le & \negthickspace\displaystyle
          \|\eta\|_{0,I}


value problem (let $\Phi(\varphi):=\Phi(\varphi;\chi)$) $$\label{2.20}
\begin{array}{l}
  {\mathcal L}[\varphi]=\Phi(\varphi)\quad\mbox{in}\ I, \\[0.2cm]
  \varphi(x_\ell)=\varphi_\ell\,,\ \varphi(x_r)=\varphi_r
\end{array}$$ with the non-linear right hand side (\[2.8\]) and given boundary data $\varphi(x_\ell)=\varphi_\ell$ and $\varphi(x_r)=\varphi_r.$ For this we start with the function $\varphi_0\equiv 0$ and consider the linear problems $$\label{2.21}
\begin{array}{l}
  {\mathcal L}[\varphi_k]=\Phi(\varphi_{k-1})\quad\mbox{in}\ I, \\[0.2cm]
  \varphi(x_\ell)=\varphi_\ell\,,\ \varphi(x_r)=\varphi_r\quad\mbox{for}\ k=1,2,\ldots
\end{array}$$ From ${\mathcal L}[\varphi_1]=\Phi(0)=0$ and the Schauder estimate $$\label{2.22}
  \|\varphi_k\|_{2+\alpha,I}
  \le{\mathcal C}_2\|\Phi(\varphi_{k-1})\|_{\alpha,I}
     +{\mathcal C}_3\max\{|\varphi(x_\ell)|,|\varphi(x_r)|\}$$ (see the global $C^{2+\alpha}$-estimate (\[6.40\]) together with the $C^0$-estimate (\[6.7\]) and the a priori constants ${\mathcal C}_2,{\mathcal C}_3\in(0,+\infty)$ following from it) we conclude $$\label{2.23}
  \|\varphi_1\|_{2+\alpha,I}
  \le{\mathcal C}_3\max\{|\varphi(x_\ell)|,|\varphi(x_r)|\}
  =:{\mathcal C}_3a,$$ where $a:=\max\{|\varphi(x_\ell)|,|\varphi(x_r)|\}.$ Using (\[2.12\]) we get $$\label{2.24}
\begin{array}{lll}
  \|\varphi_{k+1}-\varphi_k\|_{2+\alpha,I}\negthickspace
  & \le & \negthickspace\displaystyle
          {\mathcal C}_2\|\Phi(\varphi_k)-\Phi(\varphi_{k-1})\|_{\alpha,I} \\[0.2cm]
(\[4.11\]) yield (see (\[4.15\])) $$\label{4.18}
\begin{array}{l}
  \|\widetilde H_1\|_{2+\alpha,I}
  \le{\mathcal C}_4{\mathcal C}_6(\varepsilon^3+\varepsilon^2)
  \le 2{\mathcal C}_4{\mathcal C}_6\varepsilon^2\,, \\[0.2cm]
  \|\varphi_1\|_{2+\alpha,I}
  \le{\mathcal C}_4{\mathcal C}_6(\|\widetilde H_1\|_{2+\alpha,I}+\varepsilon^2)
  \le{\mathcal C}_4{\mathcal C}_6(1+2{\mathcal C}_4{\mathcal C}_6)\varepsilon^2\,.
\end{array}$$ We choose $$\label{4.19}
  \varepsilon
  \le\min
       \left\{
         1,
         \frac{1}{2{\mathcal C}_4{\mathcal C}_6}\,,
         \frac{1}{{\mathcal C}_4{\mathcal C_6}(1+{\mathcal C}_4{\mathcal C}_6)}
       \right\}.$$ Then there follow $\|\widetilde H_1\|_{2+\alpha,I}\le\varepsilon$ and $\|\varphi_1\|_{2+\alpha,I}\le\varepsilon.$ We continue this procedure to get $$\label{4.20}
  \|\widetilde H_k\|_{2+\alpha,I}\le\varepsilon,\quad
  \|\varphi_k\|_{2+\alpha,I}\le\varepsilon
  \quad\mbox{for}\ k=0,1,2,\ldots$$ From (\[4.16\]) we deduce $$\label{4.21}
  \|\widetilde H_{k+1}-\widetilde H_k\|_{2+\alpha,I}
  \le 4\varepsilon\,{\mathcal C}_5{\mathcal C}_6
      (\|\widetilde H_k-\widetilde


in (\[6.18\]) and (\[6.22\]) we prove

(Estimate of the $C^\alpha$-norm for Poisson’s equation)\
Let $u\in C^{2+\alpha}(I,\mathbb R)$ solve (\[6.30\]). Then it holds $$\label{6.36}
  \|u\|_{\alpha,I}\le\|u\|_{0,I}+(b-a)^{1-\alpha}[u]_{1,I}$$ with the above estimates of $\|u\|_{0,I}$ and $[u]_{1,I}.$

(Estimate of the $C^{1+\alpha}$-norm for Poisson’s equation)\
Let $u\in C^{2+\alpha}(I,\mathbb R)$ solve (\[6.30\]). Then it holds $$\label{6.37}
  \|u\|_{1+\alpha,I}
  \le\|u\|_{1,I}+(b-a)^{1-\alpha}[u]_{2,I}$$ with the above bounds on $\|u\|_{1,I}$ and $[u]_{2,I}.$

(Estimate of the $C^{2+\alpha}$-norm for Poisson’s equation)\
Let $u\in C^{2+\alpha}(I,\mathbb R)$ solve (\[6.30\]). Then it holds $$\label{6.38}
  \|u\|_{2+\alpha,I}=\|u\|_{2,I}+[u]_{2+\alpha,I}=\|u\|_{2,I}+\|F\|_{\alpha,I}$$ with the above bound on $\|u\|_{2,I}.$

Our main result is a global estimate of the $C^{2+\alpha}$-norm for regular solutions of (6.1b).

(Global estimate of the $C^{2+\alpha}$-norm)\
Let $u\in C^{2+\alpha}(I,\mathbb R)$ solve (6.1b). Let $$\label{6.39}
  \widehat p_1:=\|p\|_{\alpha,I}\,,\quad
  \widehat q_1:=\|q\|_{\alpha,I}\,,\quad
  \widehat p_1\!':=\|p\|_{1+\alpha,I}\,.$$ Then there exist real constants $C_1,C_2=C_1,C_2(p_0,\widehat p_1,\widehat q_1,\widehat p_1\!',b-a,\alpha)\in(0,+\infty)$ such that $$\label{6.40}
 [
  {
    "class" : "org.batfish.minesweeper.answers.SmtOneAnswerElement",
    "result" : {
      "forwardingModel" : [
        "r1,Serial0 --> r2,Serial0 (OSPF)",
        "r2,Serial1 --> _,_ (CONNECTED)"
      ],
      "model" : {
        "|0_CONTROL-FORWARDING_r1_Loopback0|" : "false",
        "|0_CONTROL-FORWARDING_r1_Serial0|" : "true",
        "|0_CONTROL-FORWARDING_r2_Loopback0|" : "false",
        "|0_CONTROL-FORWARDING_r2_Serial0|" : "false",
        "|0_CONTROL-FORWARDING_r2_Serial1|" : "true",
        "|0_DATA-FORWARDING_r1_Loopback0|" : "false",
        "|0_DATA-FORWARDING_r1_Serial0|" :


wood pulp fibers into several hundredths of a micron (one thousandth of a millimeter).

Cellulose nanofibers have been used in a variety of products ranging from ink to transparent displays, but their potential use in cars has been enabled by the “Kyoto Process”, under which chemically treated wood fibers are kneaded into plastics while simultaneously being broken down into nanofibers, slashing the cost of production to roughly one-fifth that of other processes.

“This is the lowest-cost, highest-performance application for cellulose nanofibers, and that’s why we’re focusing on its use in auto and aircraft parts,” Kyoto University Professor Hiroaki Yano, who is leading the research, told Reuters in an interview.

The university, along with auto parts suppliers, are currently developing a prototype car using cellulose nanofiber-based parts to be completed in 2020.

KyotoRajendra Stadium

The Rajendra Stadium is a multi-purpose stadium located in Katihar, Bihar. The stadium has capacity of 15,000 spectators. The stadium is a venue for football tournaments, fairs & exhibition. It is used mostly for association football matches  and the stadium is named after the first President of India Dr. Rajendra Prasad. Tenants RK Steel FC sometimes drew crowds above 10,000 for their association football matches at the Rajendra Stadium.

See also
Bihar Football Association

References

External links
 Wikimapia

Category:Siwan district
Category:Sports venues in Bihar
Category:Cricket grounds in Bihar
Category:Football venues in Bihar
Category:Memorials to Rajendra Prasad


Diagnosis and treatment of depression in the cancer patient.
Increased survival rates resulting from advances in the treatment of cancer have led to an increased interest in patients' emotional reactions and adaptations to the illness. Depressive symptoms associated with cancer range from normal sadness through acute stress response to major depression. Chemotherapeutic agents can produce depressive and other neurotoxic side effects. Diagnosis of common emotional reactions to cancer illness and appropriate management are described. Such treatment can enhance the patient's ability to adapt to the disease and tolerate its treatments.venusta was the only one you thought was cool.

Probably isn't. I just haven't put as much time into looking at them as I have VFTs, Cephs, Sarrs and Neps. I like the droseras with the red tint a lot but there are so many that venusta, prob because i have it, is the only one that stands out. I really don't like the structure of the capensis though I have one of those too. I like pitchers and traps and vivid colors....really what attracts me to CPs.


# AWS::Inspector::AssessmentTemplate

The `AWS::Inspector::AssessmentTemplate` resource creates an Amazon Inspector assessment template, which specifies the Inspector assessment targets that will be evaluated by an assessment run and its related configurations\.

## Syntax

To declare this entity in your AWS CloudFormation template, use the following syntax:

### JSON

```
{
  "Type" : "AWS::Inspector::AssessmentTemplate",
  "Properties" : {
      "[AssessmentTargetArn](#cfn-inspector-assessmenttemplate-assessmenttargetarn)" : String,
      "[AssessmentTemplateName](#cfn-inspector-assessmenttemplate-assessmenttemplatename)" : String,
      "[DurationInSeconds](#cfn-inspector-assessmenttemplate-durationinseconds)" : Integer,
      "[RulesPackageArns](#cfn-inspector-assessmenttemplate-rulespackagearns)" : [ String, ... ],
      "[UserAttributesForFindings](#cfn-inspector-assessmenttemplate-userattributesforfindings)" : [ [Tag](https://docs.aws.amazon.com/AWSCloudFormation/latest/UserGuide/aws-properties-resource-tags.html), ... ]
    }
}
```

### YAML

```
Type: AWS::Inspector::AssessmentTemplate
Properties:
  [AssessmentTargetArn](#cfn-inspector-assessmenttemplate-assessmenttargetarn): String
  [AssessmentTemplateName](#cfn-inspector-assessmenttemplate-assessmenttemplatename): String
  [DurationInSeconds](#cfn-inspector-assessmenttemplate-durationinseconds): Integer
  [RulesPackageArns](#cfn-inspector-assessmenttemplate-rulespackagearns):
    - String
  [UserAttributesForFindings](#cfn-inspector-assessmenttemplate-userattributesforfindings):
 Bundler.ui.error e.inspect
      Bundler.ui.warn "Make sure you have the graphviz ruby gem. You can install it with:"
      Bundler.ui.warn "`gem install ruby-graphviz`"
    rescue StandardError => e
      raise unless e.message =~ /GraphViz not installed or dot not in PATH/
      Bundler.ui.error e.message
      Bundler.ui.warn "Please install GraphViz. On a Mac with Homebrew, you can run `brew install graphviz`."
    end
  end
end


Dan Rather: What Everyone is Missing About Trump’s Wiretapping Claims

Dan Rather: What Everyone is Missing About Trump’s Wiretapping Claims

Dan Rather just nailed it. Again. This time, on his Facebook page, Rather went off on Donald Trump and his absurd claim that the Obama administration tapped his phones at Trump Tower during the Presidential race last year.

In the note, Rather expresses his regret that it has come to this, saying “Perhaps it is my age or experience, but I feel no schadenfreude or eagerness to say, “I told you so.” I feel only a deep and abiding sadness. This is my country that I love with all my heart. We are a weakened nation, in our own estimation, and that of the world. If this was happening in someI’m getting the Twenty Twelve theme and a missing logo file error when viewing the site at the above links. Depending on the plugin used, you may need to add its php call into the code that creates the portfolio output in the ajax style portfolio. As long as the plugin has the ability to do so and isn’t limited to shortcodes or automatically adding things in.


imagined to the distinct probability that at least a few Minoan inscriptions were in fact written entirely in Mycenaean derived proto-Greek with the syntax adjusted to the requirements of the Minoan language. I have already fully addressed this phenomenon in a previous post, which I urge you to reread, in order to place this decipherment in its proper perspective. You can read that post here:Partial decipherment of Partial decipherment of Linear A tablet ZA 15 (Zakros) and the phenomenon of orthographic adjustment of superstratum words in the substratum language:https://linearbknossosmycenae.wordpress.com/2017/05/06/partial-decipherment-of-linear-a-tablet-za-15-zakros-and-the-phenomenon-of-orthographic-adjustment-of-superstratum-words-in-the-substratum-language/I am therefore finally convinced that decipherment of Mycenaean derived New Minoan is an eminently attainable goal.

10 Mycenaean Linear B & Minoan Linear A words for plants & spices (grand total = 27):This chart lists 10 Mycenaean Linear B &Minoan Linear A words for plants & spices, with the Linear B in the left column, its Minoan Linear A in the middle column, and the English translation in the right column. It should be noted that I had to come up with a few Mycenaean Linear B words for plants on my own, because they are nowhere attested on Linear B tablets, regardless of provenance. Nevertheless, the spellings I have attributed to these words are probably correct. See the chart above. While most Mycenaean Linear B words and their Minoan Linear A words are equivalent, some are quite unalike. For instance, we have serino for celery in Mycenaean Greek and sedina in Minoan, and kitano in Mycenaean Greek versus tarawita in Minoan. There is a critical distinction


the action that you have already taken and that Parliament wants to see taken, but also to get into balance the fact that there are emissions from homes, from waste and all sorts of other areas other than just aircraft and that the Commission, working with Parliament, emphasises that this is a partnership across all of the deleterious effects of CO2 emissions so that we do not just emphasise air flights and then just miss out the emissions of shipping and vehicles. In my own city of London that is extremely important to stop the kind of pollution that we see strangling that city.
Stavros Dimas
Member of the Commission. Thank you very much for your supplementary question. I fully agree with you that we should not focus solely oncover various environmental issues, such as the spiralling increase in waste, the destruction of the ozone layer, the greenhouse effect and climate change, the importance of preventing river pollution and the importance of biodiversity. Other publications include a collection of sketches and stories by children and an educational leaflet on the Natura 2000 network. I have copies of these publications in various languages, as well as of a video of the Commission 'Climate change depends on you' strategy presented by the MTV television channel. It is a USB video and any Members of Parliament interested may take a copy. I also have a number of leaflets over there. I should also like to point out that educational programmes on the environment are eligible for funding on the basis


like you to explore further the possibilities there.
Stavros Dimas
Member of the Commission. Very briefly, you know that the LIFE + regulation is under discussion here in Parliament and in the Council. Provided that it is approved, programmes of the kind you mentioned before will be able to be financed.
Laima Liucija Andrikien
I think, Commissioner, you would agree that young children may not be old enough to understand why they should be concerned about environmental neglect, but they are old enough to appreciate the beauty of the world and to begin developing good habits as regards environmental issues.
What I understood from your reply is that you are quite satisfied with what the European Union is doing in this field so, are we doing enough? And do you have any newon the effective implementation of passengers' rights. I shall deal with this matter personally.
Jörg Leichtfried
(DE) I, too, would also like to say something on the same subject, having recently received a very large number of letters and emails, the particular burden of which is that implementation is currently not working very well at all. I would like to endorse what Mr Rack has said about the evident need for certain things not only to be better implemented but instead actually changed. There is, I believe, a need not only for implementation, but also for more stringent legislation, to deal with the problem of aircraft that are not fully booked being dropped from the schedule simply on the grounds of force majeure, and I should be interested to learn


overseeing the development of the project, and it is true that we are now awaiting clarification of the German position so that we can determine the Community position. Let me assure you, in any case, Mr Posselt, that this is an issue to which I am particularly attached. I am also just about to write a letter to the German and Austrian operators regarding the timetables between these two countries.
This is what I wanted to say to you, Mr Posselt, whilst confirming my determination regarding this very important matter.
Paul Rübig
(DE) Madam President, Commissioner, ladies and gentlemen, the route between Vienna and Bratislava is a matter of particular concern to a new Member State such as Slovakia, since it is capable of connecting two airports, and that would ofmore, the Commission rejects the unfounded statements relating to the previous decisions, which were taken after in-depth and detailed investigations had been carried out and after all the parties concerned had been invited, via the publication of an opinion in the Official Journal, to share their comments. This is the answer that I am able to give to Mr Papdimoulis's question.
Dimitrios Papadimoulis
(EL) Madam President, Commissioner, thank you for your reply, but please could you be more specific. Did the Greek court award the sum of EUR 550 million, yes or no? Give me a straight answer. Does the Commission intend to contest the final decision by the court? Does the Commission have evidence proving that the State's debts to Olympic Airways were offset in the past? And what


Member wishes, I can provide her with a list of projects. Under the current seventh framework programme, which was launched just recently, research and technological development and demonstration in the field of hydrogen and fuel cells will benefit from very extensive stakeholder consultation undertaken through the European Hydrogen and Fuel Cell Technology Platform. Established in the year 2004, this industry-led technology platform has provided the strategic direction which the sector needs in order to bring these technologies to the point of commercial readiness.
Annex 4 to the Council decision on specific programme cooperation lists a hydrogen and fuel cells initiative as one of the possible joint technology initiatives that may be established either on the basis of Article 171 of the Treaty - this may include the creation ofend of April. The energy theme includes a number of topics related to innovative materials for specific hydrogen production pathways.
I have taken longer than I intended, but I wanted to give you a broad outline of the programmes or initiatives which are in place.
DanutBudreikait
(LT) Thank you for such a comprehensive and informative answer. I am truly pleased to say that we are not far behind China in this respect; we are also working in this field. I would like to ask: these achievements are limited and there are not many hydrogen-propelled vehicles on the streets, so is it possible that there is influence from the automobile industry and from petroleum-producing countries, and are they perhaps exerting pressure and limiting research into the use of hydrogen?
Janez Potočnik
Member of the


all disciplines, over 50% of graduates, but only 15% of professors, are female. In science, engineering and technology, the figures are 34% for female graduates and 9% for female professors respectively. The Commission agrees that this is a waste of talent and resources.
Since 1999, several documents by the Commission have addressed the participation of women in European research. The Commission is devoted to gathering reliable statistical data in order to view the complete situation and it publishes these results regularly in a brochure entitled 'She Figures'. This brochure was published in 2003 and 2006, and the next publication is expected in 2009. Since the Fifth Framework Programme, the Commission has also provided financial support to studies and action in the field of women in science. In addition, undercalled on the Community to equip itself as a matter of urgency with the means to combat effectively illicit practices in the counterfeiting of medicines; called upon the Commission to go beyond its Communication, 'Strategy to enforce intellectual property rights in third countries' and in particular urged the European Union to take adequate measures to combat the scourge of the counterfeiting of medicines in its territory.
What concrete steps has the Commission taken since September 2006 to combat the counterfeiting of medicines within the EU and abroad? In particular, what measures has the Commission undertaken to enhance controls over medicines sold on the Internet?
Günter Verheugen
Madam President, the Commission is aware that the counterfeiting of medicinal products - to which the honourable Member referred - is a worldwide problem, and


seized by Customs in that year can be expected to total over 1.5 million, which amounts to a dramatic increase.
In its communication to the Council, the European Parliament and the Economic and Social Committee on how Customs might respond to the most recent developments in the counterfeiting and piracy of goods and products, the Commission put forward an action plan containing a series of concrete measures whereby this increase can be combated.
A start has already been made on two of the most important of these measures, namely the creation of an electronic system for the speedy exchange of information between customs authorities on risks of new kinds of counterfeiting and the establishment of a system through which businesses can submit to the customs authorities, as rapidly as possible,The head of Germany’s central bank has warned that London’s position as a financial centre would be dealt a severe blow if the UK left the single market because banks would be denied the right to operate across the 27 remaining members of the EU.

The “hard Brexit” option – favoured by some leading Conservative eurosceptics – would mean banks would automatically be stripped of their ability to conduct business across the EU and open the door for Frankfurt to take business away from London, the Bundesbank president, Jens Weidmann, said.

In an interview with the Guardian, Weidmann emphasised that banking “passporting rights are tied to the single market and would automatically cease to apply if Great Britain is no longer at least part of the European Economic Area” (EEA).

The


question over passporting rights is a crucial issue for Britain’s financial services industry since they allow firms to use London as a hub for serving clients from across the EU, without the need for licences in individual countries. Its importance appeared to be emphasised by data published on Sunday showing that foreign banks with affiliates in the UK account for a large share of international banking activity in London.

In the wake of Britain’s vote to leave the EU, the foreign secretary, Boris Johnson, had tried to assure US banks that the UK would retain its passporting rights even if it left the EEA, as many of Johnson’s allies are pushing for.

But Weidmann appeared to quash such a compromise, describing passporting rights as “crucial” for the City of Londonuse of this type of shared content for research could help us better understand how and why bites occur and contribute to the development of bite prevention strategies.”

Using search terms such as ‘dog bite’ and ‘dog attack’ the researchers sampled 143 videos that were uploaded to YouTube between January 2016 and March 2017. For each video the context of bites, bite severity, victim and dog characteristics were recorded. For 56 of these videos they were also able to analyse the details of human and dog behaviour leading up to the bite.

The researchers acknowledge that YouTube videos of dog bites are likely subject to some bias, with, for example, bites by small dogs perhaps perceived as ‘comical’ and therefore more likely to be uploaded online.

The findings reveal that despite


between CIMT and risk in Cox regression model including a quadratic term of CIMT change. We found a HR of 0.98 (95% CI 0.95--1.02) per SD of annual mean CCA-IMT progression (I^2^ = 10.9%, p for heterogeneity = 0.331) and of 1.22 (1.14--1.30) per SD of average mean CCA-IMT (i^2^ = 60.6%, p for heterogeneity = 0.001) for the combined endpoint.

![Forest plots of the HR of the combined endpoint per one SD of annual mean CCA-IMT change (with 95% CIs).\
Panel I: Group A (asymptomatic individuals with three or more CVD risk factors), HR adjusted for age, sex and average mean CCA-IMT (model 1). Panel II: Group A (asymptomatic individuals with three or more CVD risk factors), HR adjusted for age, sex, average mean CCA-IMT and other CVD riskof measurement precision) and the HR, again with no significant relation. To assess the influence of the ultrasound protocol, we repeated the meta-analysis for individuals with prevalent carotid plaques (group B) and grouped the cohorts into those where CIMT measurement included carotid plaques and those where plaques were avoided ([S7 Fig](#pone.0191172.s011){ref-type="supplementary-material"}). The pooled HR for the combined endpoint did not differ between these two groups.

![Meta-regression plot for the HR (combined endpoint) per SD of annual mean CCA-IMT change (model 1), by the correlation of baseline and follow-up common CIMT.\
The size of each circle represents the precision of the log HR.](pone.0191172.g003){#pone.0191172.g003}

Discussion {#sec008}
==========

Within a global collaborative project (see [www.prog-imt.org](http://www.prog-imt.org/)), we managed to amass a large proportion of the worldwide available data in high-risk individuals (52% of all eligible cohorts), in


the interpretation of clinical trials with the endpoint CIMT change, we need to know whether a group of individuals treated with a drug whose CIMT progressed [on average]{.ul} less than another group treated with another drug (or placebo), exhibits a lower event risk in the same period. This latter question has not been answered satisfactorily yet, as the current findings are contradictory.\[[@pone.0191172.ref005],[@pone.0191172.ref006]\] The criteria of surrogacy in clinical trials, that is whether the effects of interventions on CIMT parallel the effects on risk, will be addressed in stage 3 of the PROG-IMT project.\[[@pone.0191172.ref011]\]

Limitations {#sec009}
-----------

It may be argued that many of the individuals included here were already studied in our previous work on general population cohorts.\[[@pone.0191172.ref007]\] Three arguments counteract this point: First, we selected only individuals at high cardiovascularinterleukins IL-3 and IL-4 are well characterized hematopoietic growth factors which are produced by activated T-cells and by activated mast cells (92, 94, 95, 96, 97). An additional mast cell growth factor has been predicted which is produced by fibroblasts (47). In the absence of IL-3, BMMC and CTMC derived from the peritoneal cavity can be maintained by co-culture with 3T3 fibroblasts (98). However, BMKC from W/W.sup.V mice as well as mice homozygous for a number of other W alleles are unable to proliferate in the fibroblast co-culture system in the absence of IL-3 (99, 100, 38). This suggested a function for the c-kit receptor in mature mast cells and implied that the ligand of the c-kit receptor is produced by fibroblasts. Huff and coworkers recently reported the


 if (is.na(z)) {
    for (zValue in 1:maxZ) {
      fun(a, b, ..., y, z=zValue)
    }
    return()
  }
  stopifnot(!is.na(y) && !is.na(z))
  # Part of fun that does actual work follows.
  ...
}

The recursive fun calls are actually inconveniently long, a few hundred characters each, because they need to repeat every parameter given to fun. Is there any shortcut by which I can call fun recursively with all parameters but one preserved, or is there another, better way to accomplish what I'm trying to do?
For the curious: my actual fun produces a graph with data sets and options specified in the parameters, and y and z are Booleans that determine whether to graphW-2.  As a result, you don't deduct that amount on your tax return, because it has already been automatically deducted before you even begin your return.  But when you send in a contribution on your own to your HSA, that contribution is deductible on your tax return.  Your HSA should have a mechanism for making a manual contribution outside of your paycheck.
However, because you started the HSA part way through the year, your contribution limit might be less than the full $3450.  In some cases, the contribution limit is prorated based on the number of months you were HSA-eligible.  See this answer for an explanation on how the contribution limit works when you are only eligible for part of the year.

A:

Yes. There is


cold, like Jameria in Philadelphia.

But, as with textbooks and teacher salaries, addressing the symptoms of poverty costs schools precious money.

For more on Camden, click here.

'Doomed' Without Preschool

To meet the needs of its disadvantaged students, North Carolina has focused much of its effort — and dollars — on one big intervention: preschool.

In the 1990s, a handful of low-income districts sued the state, arguing insufficient funding. Wake County Superior Court Judge Howard Manning found that, for most students, the state's schools and their funding were good enough.

It was a different story, though, for what Manning called "at-risk" students — among them, kids with disabilities, living in poverty or learning English as a second language. In his October 2000 decision, Manning didn't mince words:

"At-risk children, who are not presently in qualityCommission on Religious Education in Schools which reported for the centenary of the Education Act of 1870. He became chairman of the BBC's Central Religious Advisory Committee (CRAC) in 1970. At Easter in 1972 he had a heart attack and died on 6 October 1972 after having a meeting at Broadcasting House, London with CRAC.

Theological contributions
Ramsey approached a number of philosophical problems concerning twentieth century theology. One of the significant topics concerned "God-talk" or the soundness of theological language. Much of this had been prompted by the philosophical writings of Ludwig Wittgenstein and also by philosophers such as Alfred Ayer who were involved in the mid-twentieth century movement known as Logical Positivism. The implications of Ayer's argument in Language, Truth and Logic (1936) were that religious or theological


right here… you will NEVER be in the friend zone, ever!

Understand the psychology behind it

In order to get out of the friend zone, you need to first work out why she might be doing it and this will give you a better understanding of how you can stop it from happening any further.

If she has a boyfriend (or even if she doesn’t) she still likes the comfort of having a guy like you pandering to her. You buy her drinks, call her and listen to her moaning about stuff for hours, buy her dinner… and give her the attention she craves.

She doesn’t want to start a relationship with you mainly because it could ruin the relationship she has going with you. The easy ride.

Break the pattern

By breaking thethe scent.

Make remarks about other girls when you’re with her. “Oh she’s hot” and “Do you have any hot friends you can introduce me too?”

Talk about dates you’ve been on with other girls (don’t rub it in too much though).

Show her you’re a high value male

Be the guy that’s in demand – When she tries her usual tricks, block her and make her think that you’re a high value in demand man. This will make her want to chase you and work for you.

Stop being predictable – If you speak at a certain place… stop going there. If she calls you at a certain time, don’t answer the phone. Don’t reply to texts too quickly, just make her feel like you’re cool without her and have a life.

Getting


her when we go to bars as a group and she always approaches and talks to people confidently even men she has attraction to.”

Just because someone is socially extrovert (or domineering) and takes the lead does not mean she will want to do the same with sex. Sexual activity is often escape where people can be something different (and anything repressed is let out) so why she might be (or present herself as) the empowered business woman when it comes to sex in this case she likely desires to be submissive and let the man take charge. It’s like the quiet lady who works in the library and goes to book clubs is also into BDSM and dominating guys. It can be very much opposites.

“however when she getshad been found on the plaintiff’s clothes he admitted that the incident had taken place. The ruling noted that the policeman’s version stated that “after taking the plaintiff to the bathroom, handcuffed and blindfolded, and after the plaintiff had used the bathroom, the policeman asked him to stand by so he could also use the bathroom. He told the plaintiff to bend over and go down on his knees, after which he urinated on him.”


a pre-election target of 100,000 members in November, when the SNP was 85,000-strong.

Handing over the leadership of the party to Sturgeon, he said: "Let us ensure that by next May's election, the SNP reaches a level which has never been seen before in Scottish politics - 100,000 members representing the national cause."

However, despite an explosion in membership in the weeks immediately after September 18, the pace of recruitment later slowed.

The last time the party revealed its membership was in January, when it was around 93,000.

Next week's conference at the SECC is expected to feature 3,000 delegates, 150 per cent more than the SNP's November gathering, as well as 200 journalists and 42 exhibitors.

SNP election campaign director Angus Robertson said: "Next weekend's conference will be by far the biggestRoad and Mayo Road — choking the business district and having a ripple effect from north to south. The 3,000-odd cops deployed turned out to be woefully inadequate for a gathering of such strength and such aggressiveness. DC-central D P Singh suffered a head injury that needed three stitches. Joint CP-traffic Supratim Sarkar and DC-south Murli Dhar Sharma, too, were injured as the mob pelted stones and turned Jamiat flagstaffs into lathis.

Jamiat leader Siddiqullah Chowdhury blamed police for the violence. “There was tension when police drove a car through the rally. The (police) action and combative reaction of a section of rallyists are both unwarranted. We have been holding rallies for years. This never happened. I suspect some outsiders sneaked into our rally to discredit us. They need


 //Default constructer required for XML serialization.
        public Hero()
        { }

        /// <summary>
        /// This method returns a hero full of the necessary information.
        /// </summary>
        /// <param name="Name">Name of the hero.</param>
        /// <returns>Returns an instace of the Hero class chock full of information.</returns>
        public Hero GetHero(string Name)
        {
            Hero NewHero = new Hero();

cause unsightly marks in the face frame itself at the contact points. In addition, using these types of clamping devices are intrusive, thus making it difficult for the manufacturer to work around.
Other, more elaborate, clamping devices exist which serve to secure the joint of the face frame during its assembly. These devices are capable of accepting the face frames and clamping the joints of the face frames during construction. The clamping assemblies used by these devices commonly utilize one or more pneumatic or hydraulic piston cylinder or rams which causes a ram to exert a substantial amount of force upon the face frame at the joint area. This force holds the joint in proper alignment while the manufacturer installs the fastener (e.g. screw) into the joint. However, these


      }

    // test protected
    protected static class Level0
        {
        private String  Level0_Name    = "val-Level0Member";
        private Nested0 Level0_Nested0 = new Nested0();
        public String toString()
            {
            return "toString " + Level0_Name;
            }
        }

    public static class Level1 extends Level0
    in January to deal with Illinois' massive budget deficit.

The WARN Act mandates that when more than 75 workers are laid off, they must get 60 days notice (or 60 days severance pay), theoretically to help government and social service agencies prepare for the influx of need.

State reports listing WARN Act notices are a good way to track pending layoffs, though they of course don’t include smaller businesses or situations where employers lay off workers in waves that avoid the definition of a mass layoff, sometimes intentionally. The listings indicate whether an employer is union – for example, January WARN Act notices include Teamsters at a chocolate confection company and IBEW workers at a closing power plant.

The layoffs also come at a Chicago bakery, two closing K-Marts, a CD


because he's a hockey player, but the kind of person he is."

Crosby was a late addition to the women's under-18 invitees this week as the initial roster was seven.

"You never want to miss anybody," Hockey Canada's female scout Melody Davidson said. "She had shown potential in past years so it's probably a good move to take a look at where she's at, someone you don't get to see often and eligible to play for our country."

Davidson has watched Crosby play a few times over the years.

"Pretty good size in the net and she uses that size well," is Davidson's scouting report. "How she's going to mature and grow as a goalie is what we're checking in on and we'll see how it goes from there.

Story continues below advertisement

"She'sa page isn't necessary, but I'd be remiss if I didn't offer you another option. This should be a viable workaround for not having the page you're looking for, all opinions aside.

Edit: I suppose I got a bit excited with all this, and failed to recognize the comment left by gnat, which appropriately suggests that using the built-in search functionality is completely sufficient to do what you're looking for.
To construct that search query, you'll want to filter by user and hasaccepted. For you on Stack Overflow, I believe that should look something like:
user:me hasaccepted:no

But, if you're like me and enjoy the over-complication of simple tasks, here's a nice step in that direction. That said, I think this searching option is actually more reliable for a couple reasons, including


you're looking for. Someone else may make it a bit prettier, and perhaps more efficient (I was feeling a LEFT OUTER JOIN vibe, but a nested subquery might be cleaner), but this should tell you a few things. Specifically, it will tell you which questions a given user has asked which have no accepted answer, and for each of those, how many answers are present.
SELECT DISTINCT questions.Id AS [Post Link], SUM(IIF(answers.Id IS NULL, 0, 1)) AS AnswerCount
FROM Posts questions
  LEFT OUTER JOIN Posts answers ON questions.Id = answers.ParentId
WHERE questions.PostTypeId = 1
      AND (answers.PostTypeId = 2 OR answers.PostTypeId IS NULL)
      AND questions.OwnerUserId = '##UserId##'
      AND questions.AcceptedAnswerId IS NULL
GROUP BY questions.Id

It may be usefulSteven Marcussen Mastering about how exactly the transfers were done. Ultimately The Rolling Stones own the masters on this album, have been involved and have approved Steven’s work on this release. In reality it is their album and whatever anyone else might feel about the sound, it is the artist’s decision on exactly how it should be presented. I would personally say that it is not for me or anyone else to over-rule them on this point.

Also, key to all of this is what A/D converters were used in the original transfers and what D/A converters were used for the lacquer mastering, as every digital converter has a signature sound (despite claims to the contrary), some better than others and some worse.

MS: This is easy to answer. At


equipment. How do I know this? He and I had several email chats, he was delighted that I was so inspired by his work and was extremely helpful to me with tips and advice when I was attempting to get the half-speed ball rolling again around 15 years ago.the type signature to:
getFromDoubleAccepter :: (forall m. (Monad m) => Accepter m (Accepter m t)) -> t

which still works with our example.  Of course, this is all a bit silly. Consider
   forall m. (Monad m) => Accepter m (Accepter m t))
=  forall m. (Monad m) => (t -> m ()) -> m ()

The only thing a function with this type can do is call its argument with various ts in order and then return ().  The information in such a function is completely characterized[1] by those ts, so we could just as easily have used
getFromDoubleAccepter :: [t] -> t
getFromDoubleAccepter = head

[1] As long as I'm going on about nothing, I might as well say that that is not quite accurate in the face


wear well to talk about how well something lasts over a period of time. For example, if something wears well, it still seems quite new or useful after a long time or a lot of use. it is fine to use this expression about people.
The expression wear greatly does not work: greatly is about a large quantity, so it sounds like Tom's grandad looks older than his years.

specific prior written permission.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS
// "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT
// LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR
// A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT
// OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
// SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT
// LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE,
// DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY
// THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT
// (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
// OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.

package proto

import "errors"

// Deprecated: do not use.
type Stats struct{


Emalloc, Dmalloc, Encode, Decode, Chit, Cmiss, Size uint64 }

// Deprecated: do not use.
func GetStats() Stats { return Stats{} }

// Deprecated: do not use.
func MarshalMessageSet(interface{}) ([]byte, error) {
	return nil, errors.New("proto: not implemented")
}

// Deprecated: do not use.
func UnmarshalMessageSet([]byte, interface{}) error {
	return errors.New("proto: not implemented")
}

// Deprecated: do not use.
func MarshalMessageSetJSON(interface{}) ([]byte, error) {
	return nil, errors.New("proto: not implemented")
}

// Deprecated: do not use.
func UnmarshalMessageSetJSON([]byte, interface{}) error {
	return errors.New("proto: not implemented")
}

// Deprecated: do not use.
func RegisterMessageSetType(Message, int32, string) {}
with NAFLD. They may also have the added benefit of reducing the incidence of T2DM. A previous meta-analysis of more than 100 000 patients also showed a 20% reduction in the incidence of new onset diabetes with the use of ACEI or ARBs.[@R65]

Dyslipidaemia {#s4c}
-------------

Dyslipidaemia is very common in patients with NAFLD and the metabolic syndrome. Effective treatment of dyslipidaemias is vital in the management of NAFLD to reduce patients' cardiovascular risk profile. NICE guidelines[@R66] recommend simvastatin treatment as primary prevention for cardiovascular disease in adults with a ≥20% 10-year risk of developing cardiovascular disease (using a risk calculator such as the Framingham risk calculator). More aggressive lipid control is recommended for secondary prevention of cardiovascular disease, aiming for a total cholesterol \<4 mmol/L. A meta-analysis confirmed that statin therapy safely


summarises the management of the complications of NASH cirrhosis.

Liver transplantation {#s5d}
---------------------

NASH cirrhosis is now the third commonest indication for liver transplantation in the USA and accounted for 12% of patients listed for transplantation in the UK in 2009.[@R96] Patient and graft survival in liver transplantation for NASH are comparable with other indications.[@R96] [@R97] Although recurrence of NASH is common post-transplant, occurring in 4%--25% of patients, it does not appear to impact on graft survival.[@R98] [@R99] Patients who are transplanted for NASH cirrhosis frequently have multiple cardiovascular risk factors that should be managed aggressively post-transplant to prevent cardiovascular-related mortality.[@R100] UK guidelines on liver transplantation suggest that bariatric surgery can be considered at the time of liver transplantation for patients with NASH and morbid obesity.[@R100]

Summary {#s5e}
-------

Lifestyle interventions aimed at weightQ:

Shiny::renderPlot - cannot set resolution reactive

Hi my second week with shiny. I'm coding an app, where a plot window and some plot control buttons needs to appear at some point. I use renderUI() and renderPlot(). I can have the user to update plot parameters renderPlot(expr={ [inside here] }).
,but I cannot have the user to change the plot resolution renderPlot(res=[some reactive variable outside here],expr={ })
I have posted test example below, Thanks alot.
library(shiny)

ui = fluidPage(
  uiOutput('thisPlot'),
  uiOutput('plotOptions')
)

server <- function(input, output) {
  #some plot options which will appear by some event
  output$plotOptions <- renderUI({
    if(TRUE) {list(
      radioButtons('plot.log', 'log axis',
                   c('none'= ''


O. Yildirim, K. Potzger, and A. Hütten, Acta Mater. **86**, 279 (2015). N. Teichert, “Shape Memory Heusler Alloys for Thin Film Applications”, Doctoral Thesis (Bielefeld University, 2016). K. Marklund and S. A. Mahmoud, Phys. Scripta **3**, 75 (1971). C. Smithells, *Smithells Metals Reference Book*, Butterworth-Heinemann (1992). V. Askarpour, M.H. Manghnani, S. Fassbender, Y. Yoneda, Phys. Chem. Minerals **19**, 511 (1993).

[^1]: Reference \[\]

[^2]: Reference \[\]

[^3]: Reference \[\]
small bowel loops with abundant fecal material.](ir-12-74-g001){#F1}

![Gross findings during surgery. Ileocecectomy, rectal repair (yellow square), and small bowel and sigmoid resection (black square) were performed.](ir-12-74-g002){#F2}

![Postoperative abdominal CT scan. It showed a fistula (black arrows) and intraperitoneal abscess (white arrows), which needed percutaneous drainage (A: coronal view, B: axial view).](ir-12-74-g003){#F3}

![The follow-up abdominal CT findings. The abscess and fistula disappeared (A: coronal view, B: axial veiw).](ir-12-74-g004){#F4}


Tesla overtakes General Motors to become the most valuable car maker from United States

For the first time in the era of the modern automobile, the most valuable U.S. car maker is not based in Detroit. Silicon Valley's Tesla Inc overtook General Motors on Monday to become the U.S. car maker with the largest market capitalisation as the century-old automobile industry increases its reliance on software and cutting-edge energy technology.

That milestone is likely to be on the minds of Tesla Chief Executive Elon Musk and GM Chief Executive Mary Barra as they and other CEOs visit the White House on Tuesday to discuss tax reform and infrastructure with President Donald Trump.

Helped by an analyst's recommendation, Tesla rose 3.26 percent to a record high of $312.39 on Monday. Its marketplaintiff's complaint was not with procedure, but with the validity of the stated reasons for her discharge.  The court recognized that she

22
was allowed to give her version of the events at length and in detail at the school board hearing.  She was given ample notice of the hearing [and] was represented by counsel at the hearing....26

23
Nothing in Ford suggests that school boards have discretion to terminate employees without adequate notice and a hearing.

24
Samuel was informed of the termination proceedings twenty minutes before the hearing.  He did not have the opportunity to introduce evidence, call witnesses, or contest the accusations against him in any way.  These facts are sufficient to state a violation of his due process rights.

25
The final step in the qualified immunity analysis


is whether the district court erred by not concluding that Holmes's conduct was "objectively reasonable" as a matter of law.  The court highlighted Holmes's awareness of the Board's regulations, entitling Samuel to three levels of hearings.  The court also noted Holmes's knowing failure to provide a level III hearing--and his awareness, based on his attempted justifications, that his conduct likely violated the regulations.27  Given these facts, we cannot say that the court erred in refusing to grant Holmes qualified immunity on the § 1983 claim.

B. FCA Claim

26
The defendants contend that they are entitled to qualified immunity from Samuel's claims under the FCA.  The FCA's whistleblower provision grants a private right of action to

27
[a]ny employee who is discharged, demoted, suspended, threatened, harassed, or in anyDevin Thomas may not have gotten much of a chance to show what he can do at wide receiver, but he certainly made an impact on special teams with the Giants.

Thomas played a part in helping the Giants get to the Super Bowl last season with two key fumble recoveries on punts in the NFC Championship Game against San Francisco. On Wednesday night, Thomas agreed to a one-year deal with the Bears, according to the team's website.

Tim Farrell/US Presswire

Devin Thomas (15) is now a Bear.

Thomas leaves the Giants only having caught three receptions for 37 yards in his nearly two seasons with the team. He played primarily on special teams as a returner and on the coverage team, where he made his biggest contribution, which included a fumble


* PSUtils is a collection of utilities for manipulating PostScript documents. Programs included are psnup, for placing out several logical pages on a single sheet of paper, psselect, for selecting pages from a document, pstops, for general imposition, psbook, for signature generation for booklet printing, and psresize, for adjusting page sizes. PSUtils is available for [http://gnuwin32.sourceforge.net/packages/psutils.htm windows] and [http://www.knackered.org/angus/psutils/ Linux].

This is a linux script using psbook, called thus :

This is a linux script using psbook, called thus :

−

script1a foobook

+

script1a foobook
 where the input file is named foobook.ps. It will substitute "foobook" for every occurrence of "$1". The result will be two files named "foobooke.ps" and "foobooko.ps, set up for running the paper twice through my Ricoh laser printer. For another printer I might need to eliminate the "-r"Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.
Enteropathogenic and enterohemorrhagic Escherichia coli cause enteric diseases resulting in significant morbidity and mortality worldwide. These pathogens remain extracellular and translocate a set of type III secreted effector proteins into host cells to promote bacterial virulence. Effectors manipulate host cell pathways to facilitate infection by interacting with a variety of host targets, yet the binding partners and mechanism of action of many effectors remain elusive. We performed a mass spectrometry screen to identify host targets for a library of effectors. We found five known effector targets and discovered four novel interactions. Interestingly, we identified multiple effectors that interacted with the microtubule associated protein, ensconsin. Using co-immunoprecipitations, we confirmed that NleB1 and EspL


meeting, Lopano also received praise from the board during his annual evaluation – but no pay raise, like in previous years. Lopano's annual salary is $393,824.02, per an amendment to his contract that went into effect in October last year. On April 5, 2018, Lopano will receive another 15 percent pay bump.

Lopano did not push for a raise Thursday, despite scoring top marks in nearly every category from every board member for a final score of 4.96 out 5 on his evaluation. That's the same score he made last year.

"I'm very happy where I am," he said.

Previous Coverage: Tampa International Airport CEO Joe Lopano gets another raise, to $393,824

Also at the meeting airport officials introduced a new police chief, Charlie Vazquez. He replaces Paul Sireci, who stepped downgetting crowded at the top: last year’s top ten had scores ranging from 9.8 to 9.0, while this year the tenth best has a score of 9.3.

And now, here’s Critiki’s Ten Best Tiki Bars in the World for 2016:

Any list of the best tiki places that isn’t topped by the Mai-Kai is to be ignored. There’s simply no matching the Mai-Kai, in either the grand scale, or the minute attention to detail in the decor. The Mai-Kai has multiple dining rooms, each themed for a different island group, a literal ship-shape bar, a gift shop, winding tropical gardens, musicians, dancers, and an array of Oceanic art and culture on display every way you turn. The rich history of the Mai-Kai, a family-run institution for 60 years (not counting


or control over how their data was disclosed, and to date, Facebook has not been able to tell the OAIC which Australian users were affected.

The Guardian and Observer revealed data analytics firm Cambridge Analytica worked with Donald Trump’s election team and the Leave campaign in the UK Brexit referendum.

The data was used to build a software program to predict and influence voters. Facebook discovered the information had been harvested by a third party in late 2015, but failed to alert users at the time.

In a statement, a Facebook spokeswoman said the company had been engaging with the OAIC on this matter for two years.

“We’ve made major changes to our platforms, in consultation with international regulators, to restrict the information available to app developers, implement new governance protocols anda grave lesson: Just because your hookup buddy is only hooking up with you doesn't mean he wants something more. He wants you, but he doesn't need you. He'd prefer you, but he can live without you. It's like my writer friend Treez says: "I want sex. But I need to breathe."

Fair. Succinct. And brutally honest. In fact, so honest that on this one, you almost can't help but take your hook-up buddy's side.


 h,
     mi,
     s,
     ms,
     sort_id,
     tran_id,
     value;

When I execute it in Microsoft SQL Server Management Studio I get this error:

Msg 4108, Level 15, State 1, Line 27
Windowed functions can only appear in the SELECT or ORDER BY clauses.

because of the line AND row_number() OVER (ORDER BY (SELECT NULL)) <= CONVERT(DATETIME, '2016-03-18 23:59:00', 102) -CONVERT(DATETIME, '2016-03-18 00:00:00', 102)+1 I could not find a workaround which works for my query as well.

A:

you can not use window funtion in where clause but you can check that on next layer in subquery or cte
    SELECT *
    FROM
    (SELECT0 run_id,
          0 tran_id,
          0 sort_id,
          ' ' tran_type,
              10 prod_id,
              72 type_id,
              1 value,
                CONVERT(DATETIME ,'2016-03-18 00:00:00', 102) + row_number() OVER (ORDER BY (SELECT NULL)) -1 + convert(varchar(8), sw.end_time, 8) event_publication,
              DATEPART (YEAR


Andrew Zimmern is not pleased with Yelp. The Bizarre Foods host and former chef recently slammed the user review site, saying it “essentially gives a tremendous forum for a bunch of uninformed morons to take down restaurants.” Defenders of Yelp and other crowdsourced review sites, such as Zagat, Chow and others, say that the range of reviewers — some morons, some not — at least gives a broad spectrum of opinion, which is more than you can say for a traditional restaurant critic.

But in my experience, Zimmern is right: the reviews are, at best, wildly uneven. In an earlier, more primitive stage of my food-writing career, I had the eye-opening experience of editing a Zagat dining guide for Long Island. I got to see all the reviews fortotally unknown in the Italian food , for example before the Mexican got into the Italian kitchen we knew as spicy ingredient only the crushed red peppers which time to time some client like to spread it on pasta or other dishes and has a unique flavor because its not overwhelming hot, and it goes well with many Italian dishes, but Mexicans have introduced Jalapeño peppers which was never know before, but the worst thing is that this pepper is not only extremely hot at the point that will kill any flavor of the dish, in fact in the very fancy restaurant hot peppers is not even available because is killing the flavor of the dish, but this example of changing things around will simply slowly destroy the


cheap imitation made in America because the imported is too expensive, which is the shame of the Italian culture because the flavor versus the real parmigiano imported is practically zero, but more over Parmigiano is only one flavor good for many dishes but not good for everything for example as delicious parmigiano can be but for the spaghetti with red tomato sauce you MUST use pecorino , the word pecorino means from sheep milk , pecora in Italian means Sheep, there is a total different taste which only a real Italian can taste and understand. Unfortunately real sheep milk cheese is very hard to come by and that cheap brand called Locatelli that you see in your near supermarket is only the name but there is no qualitySure enough, our employees reported that she want to every rating service and make up a big story about how my wife called her a f***ing bi*** when she couldn't get away with overcharging her, etc.

Look at every picture you can? Of what? The food? Yea, that's going to tell you a lot....The interior? Sure, that's another wildly subjective area of like or dislike. The exterior? The parking lot? Dumb.

As a small restaurant owner in the first two years, I have seen great inequities and hash unfairness with Yelp. Firstly, as other have pointed out, good reviews often get hidden just because it was near the initial creation of the Yelp page, or the reviewer has just a few reviews. Meanwile, people that seem to love to not


You can also follow people who's taste and reviews you trust. It's definitely better than Zagat.Needless to say, sometimes you still get burned by a good yelp review, especially if it only has 5-10 options, but that is part of the fun of trying new places, sometimes you find a gem, sometimes you get a bad meal. For instance, a good review on pizza will have comments on what they ordered, how the sauce was, what the crust was, and possibly of other places that it compares to. You can describe if something has been sitting out for awhile, if the fish was old, if the vegetables were crisp, if lettuce was too limp, things of that nature. You can definitely describe service quality without saying good orsurroundings.

Curious crowds, accustomed to women taking a low profile in Egypt, often congregate to watch the training, sometimes taking pictures and filming. But the women keep up the training unhindered, insisting that no sport is exclusive for men.

“It is natural that people did not accept it because they were not used to it,” said Zayneb Helal, one of the players.

“They did not accept the idea that girls could play sports, let alone on the street,” she added.

It is uncommon for women to play such sports on the streets in Egypt. A 2017 Thomson Reuters Foundation survey of experts on how women fared in mega cities rated Cairo as the world’s most dangerous megacity for women, while London came out as best.

“Women are now training and more women are


teenage son reportedly died in November while trying to rescue their dog from the ocean at Big Lagoon, 300 miles north of San Francisco. The dog had been pulled into the ocean after being hit with a 10-foot wave while retrieving a stick, according to press reports.

On New Year’s Day, another man died off the coast of Point Reyes after trying to rescue his wife and dog from the ocean. The woman was reportedly pulled out of the water by Good Samaritans, and the dog swam out on its own.

But Picavet said that even six inches of water is enough to knock a full-size adult over. In addition to being mindful of the power of the ocean, she and others at Friday’s press conference urged caution around theOakland/Alameda Estuary and other bodies of water, adding that drowning is the number one cause of death in national parks.

The groups urged people to be safe around the water, but they also offered advice for people who get pulled out to sea by a rogue wave or rip tide. Coast Guard rescue swimmer Gabe Pulliam said anyone who finds themselves caught in a rip current should try to remain calm and either swim parallel to shore until the current releases them or tread water and yell for help so they can be rescued. And Picavet urged anyone who sees another person or dog in distress should call 911.

She said that if a dog is pulled into the ocean by a wave, its owner follow the dog along the


Vietnam posted a trade deficit of $196 million in March, lower than an initial government estimate of $300 million, Vietnam Customs said on Tuesday.

Exports last month were $12.28 billion, up 29.3 percent from February, while imports rose 24.2 percent month on month to $12.47 billion, the customs department, which operates under the Finance Ministry, said on its website .The students have started working in the final program they will learn this semester…InDesign. In this program, the students will learn how to create advertisements, a personal newsletter and their final project will be a portfolio. They will also see… Continue Reading →


           reader = (NetCDFImageReader) unidataImageReaderSpi.createReaderInstance();
            reader.setInput(destFile);
            int numImages = reader.getNumImages(true);
            LOGGER.info("Found " + numImages + " images.");
            for (int i = 0; i < numImages; i++) {
                Slice2DIndex sliceIndex = reader.getSlice2DIndex(i);
                assertNotNull(sliceIndex);
                       assertNotNull(cs);
            final List<CoverageSlice> granules =
                    cs.getGranules(new Query(typeName, Filter.INCLUDE));
            checkGranules(granules);

        } finally {
            if (reader != null) {
                try {
                    reader.dispose();


For more delivery information including international options click here

If you are not completely satisfied with your purchase, simply return the items to us in their original condition and packaging within 100 days of receipt of your order for either an exchange of product or a refund. Click here to see our full returns information

Description

DC have been one for the leaders in extreme sports for years now, always pushing boundaries and trying to find new heights. Whether you skate, snowboard, BMX or FMX, you will know how big DC are and how much they do to push each sport forward.

The DC Snappy hat features an embroidered, 3D design on the front with a peak, with a green under peak and snapback at the rear, this hat has a classicUsing the purified PCR products, biotinylated transcripts were obtained by reverse transcription using the MaxiScript T7 kit (Ambion, Waltham, MA) and biotin-CTP (Enzo Life Sciences, Farmingdale, NY) [@bb0165]. Protein lysates (120 μg/sample) were incubated with 1 μg of biotin labeled transcripts for 30 min at room temperature, and then, the protein-RNA complexes were isolated using streptavidin-coupled Dynabeads (Invitrogen, Carlsbad, CA). Proteins bound to biotinylated transcripts were assessed by Western blotting.

2.4. Ribonucleoprotein immunoprecipitation {#s0030}
------------------------------------------

Ribonucleoprotein immunoprecipitation assay was previously described [@bb0170]. Briefly, whole cell lysates were incubated with anti-hnRNP A1 or control IgG-conjugated protein-A beads at 4 °C for 2 h. After further incubation of immunoprecipitated complex with DNase I and protease K, RNAs were isolated using acidic phenol. cDNAs were synthesized using random hexamers and reverse transcriptase (Toyobo, Osaka, Japan) and relative Drp1 mRNA


HuR modulates mitochondrial morphology in U2OS cells [@bb0210]. However, the role of RBPs in mitochondrial dynamics is largely unknown. In the present study, we firstly showed that hnRNP A1 regulates Drp1 expression by directly binding to Drp1 mRNA.

In order to identify novel Drp1 regulatory RBPs, we generated a small-scale siRNA library set composed of 10 well-elucidated RBPs. We screened the siRNA library set and identified hnRNP A1 as a novel regulator of Drp1 expression in neuroblastoma cells ([Fig. 1](#f0005){ref-type="fig"} and [Supplementary Fig. S1](#ec0010){ref-type="supplementary-material"}). hnRNP A1, which belongs to the hnRNP subfamily, plays a role in pre-mRNA splicing, and predominantly localizes to the nucleus [@bb0215], [@bb0220]. hnRNAP A1 is also known to function as a post-transcriptional regulator, influencing mRNA turnover and translation in cytoplasm [@bb0225]. Various targets, such aswas normalized with firefly luciferase activity. Data are represented as the mean ± SEM (n = 3, and \* p \< 0.05 value).](gr1){#f0005}

![Down-regulation of hnRNP A1 induces mitochondrial elongation.\
SK-N-MC cells stably expressing mito-YFP (SK-N-MC/mito-YFP) were transfected with control scrambled siRNA (Sc) or siRNA against hnRNP A1 (sihnRNP A1) for 3 days. (A) Representative fluorescence pictures showing mitochondrial morphology. The siRNA for Drp1 (siDrp1) was used as a positive control. (B and C) The mitochondrial length (B) and mitochondrial morphology (C) were monitored using a fluorescence microscope. (D) The expression of hnRNP A1 (si\#1, si\#2) and Drp1 by their siRNA was confirmed by Western blot analysis with each antibody. Data are represented as the mean ± SEM (n \> 3, and \*p \< 0.05 value).](gr2){#f0010}

![Down-regulation of hnRNP A1 inhibits 3-NP induced mitochondrial dysfunction and cell death.\
SK-N-MC cells were transfected with either control


scrambled siRNA (Sc) or specific siRNA for hnRNP A1 (hnRNP A1 si\#1, si\#2) for 3 days. The cells were subjected to 3-NP (10 mM) treatment for 8 h. The siRNA for Drp1 (siDrp1) was used as a control. (A) Mitochondria membrane potential was measured using a TMRE assay system. (B) The intracellular ATP level was determined using an ATP bioluminescence assay system. (C and D) SK-N-MC cells transfected with either scrambled (Sc) or hnRNP A1 siRNA (si\#1, si\#2) for 3 days were treated with 3-NP (10 mM) for additional 24 h. (C) Cytotoxicity was measured by using a LDH activity assay system. (D) The cell death was assessed by Western blotting with a cleaved caspase-3 antibody. Data are represented as the mean ± SEM (n \> 3, and \*p \< 0.05 value).](gr3){#f0015}

![Over-expression of hnRNP A1 enhances expression of Drp1.\
SK-N-MC cellsPractice Law

8
Relying on Solina v. United States, 709 F.2d 160 (2d Cir.1983),1 Pack argues that because he was primarily represented by an individual not licensed to practice law he was denied effective assistance of counsel.

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While Pack's argument might have had merit had Coiner actually rendered legal assistance to Pack, the record amply supports the district court's conclusion that Coiner did not represent or render legal assistance to Pack.  Specifically, at the hearing before the Magistrate, Coiner testified that he was hired by the law firm of McBrayer, McGinnis, Leslie and Kirkland as a law clerk in December of 1982, while he was completing his third year of law school.  He added that he was first introduced to Pack in August of 1983, in name only and