The present invention relates to a finger-touch coordinate input apparatus of a touch screen system, which allows direct information input to an information processing apparatus from a coordinate position on a display screen by pointing out a desired position on a display of a cathode ray tube (CRT) display device (or some other like device).
As a coordinate input apparatus of a touch screen system of this type, the following two systems are generally well known in the art. A first system includes a touch pad which is adhered to a display screen, such as a tube surface of a CRT display device, and a capacitance change (i.e., a parameter change) caused by pressing a predetermined point of the pad with a finger tip is detected, thereby determining acoordinate position. In a second system, a plurality of opposite light-emitting and light-receiving element pairs are arranged along upper, lower, right, and left side edges of a tube surface (display screen) of a CRT display device to obtain a matrix-like optical path, whereby light-receiving states along the X- and Y-axes are scanned, thereby determining a coordinate position pointed out by a finger tip from a shielded, or interrupted, light path. In the later optical system using the above-mentioned light-emitting and light-receiving elements, unlike the former system, a display screen is not pressed directly by a finger or other pointed object, so that the screen is not contaminated by dirt and the image on the screen remains clear, resulting in greater practical advantages.
In the conventional optical finger-touch coordinate input


gent, and he takes it in his left hand. The lady places her right hand at the right side of her waist or slightly behind her right hip, and the gent holds this hand loosely with his right hand. The lady might also use her right hand to hold on to a full skirt with petticoats, sway the skirt in time to the music as a flourish (“skirtwork”), or simply place her hand on her waist. In this case, the gent places his right hand on the small of her back.
 Skater’s handhold:  Both hands are held in front of the partners at waist-level.  The left hands are held in front of the gent’s waist; the right hands are held in front of the lady’s waist.by the cells. When BFC-1 beta were treated with heparin to eliminate heparin-sensitive cell surface binding sites, LPL binding to the cells decreased and release of newly synthesized LPL activity increased. 125I-labeled LPL binding to control cells was reduced (> 70%) by a 50-fold excess of unlabeled LPL. The residual LPL binding to heparin-treated cells was, however, not decreased by the addition of unlabeled LPL. These data imply that specific adipocyte surface LPL binding involves heparin-sensitive sites. We hypothesize that the heparin-releasable, 116-kDa LPL-binding protein mediates specific LPL binding to adipocytes and that LPL activity within adipose tissue is regulated, in part, by the interaction of LPL with this binding protein.


WEDNESDAY

EL YUNQUE PEAK = 3496 feet

Arrived in San Juan at 2:30. Eric met me at the exit and took me straight to El Yunque. Arrived at about 4:00PM. To officially camp in the park, you need to get a permit from the El Yunque Ranger Office, but it closes at 3:00PM. We got there at around 4:30PM, so I had Eric take me straight to the El Yunque trail-head.
NOTE:

Taxi’s will charge you $65 to take you from the airport to the entrance to the park, but not into it. It has something to do with liability—leaving customers up in the park (They are not allowed to come into the park and wait to pick people up--takes away from the travel agencies).

So I found a guy on CraigsList (Eric)buildings onto Road 10) I hiked up the road for about 10 minutes and came to El Yunque observation tower.

I laid out my bags and clothes to dry. Quite windy but scattered sun. The observation tower is open so you can walk inside it in case it rains. But the wind throws the rain inside so it’s wet inside. After tourists started arriving, I packed up my things and walked 10 minutes down 10 to the Roca EL Yunque trail sign. Its past the El Yunque trail where you emerge from the forest, and on the right side, right after another maintenance building (In fact, it starts behind the building). I walked this trail for about 10 minutes, climbed a few rocks and found a ledge to dry


nanorod aggregation. The obtained surface work can map aggregation regimes as a function of different nanoparticle surface conditions. Also, the thermodynamic treatment can be used to obtain quantitative information on surface effects impacting biomolecules on nanoparticle surfaces.up with bruises?" "Kids are good at keeping that sort of stuff from you." "Yeah." "Baggy clothes'll hide a lot." "Yeah." "The boyfriend's a bookie." "Wimbledon dog track." "You're too late." "Danny's mum moved out three months ago." "Well, do you have an address?" "From day one, Mandy and that kid of hers were nothing but trouble." "Everything OK, babe?" "Nothing to worry about, sweetheart." "I see you bounced right back." "Mandy left me." "She ripped me off." "As for Danny?" "Bloody hell, when he weren't drawing, he was bouncing off the walls." "I reckon the reason Mandy got stoned half the time was cos of him." "What about you, Stevie?" "You ever need to make Danny see sense?" "I've never hit a kid." "Stevie." "Just give us


get my head around this." "Unbelievable." "Well, do you believe Andy's story?" "Little kid like Jono does that to his mate?" "The facts all fit and it's definitely possible." "I tell you what, if he did do it, the case could go nuclear." "The press'll be all over him like a rash." "PHONE RINGING" "CPS." "Hello, Alesha." "Are we done now?" "Can I go?" "Jonathan Blake, we're charging you with the murder of Daniel Jackson." "I'm gonna need summaries of all murder or manslaughter cases from the last 30 years, where the killer was under 16 - Aw." "Still?" "Bless." "Play nicely, Bea." "Jono Blake is innocent." "He's just a scared little kid who's been stitched up by his mate... and you." "He's on CCTV with Danny minuteshas to be drawn on youth crime and we're drawing it." "Is that what you think?" "I think Danny's mother needs us to provide justice for her son." "All persons who have anything to do with my Lords, the Queen's Justices of the Central Criminal Court, draw near..." "At least Judge Anderson agreed to hear the trial in private and keep the public and the press out." "God save the Queen." "Case of Crown and Jonathan Blake." "Imagine being in that dock when you were 13." "I tried to stop him but he just lost it." "It was like he was someone else." "Jono kept kicking Danny over and over." "I legged it cos..." "Cos I was scared." "Out of the three of you, Andy, who's the tallest?"


more or
less than the aggregate amount called for in the surveys of the tracts within it, the proper course
is to apportion the excess or deficiency among the several tracts. Humble Oil & Refining Co. v.
Manziel, 187 S.W.2d 149, 152 (Tex. Civ. App.–Texarkana 1945, writ ref’d w.o.m.). Where a
length of a line of the same survey varies from the length called for, it is presumed, in the
absence of circumstances showing the contrary, that the variance arose from imperfect
measurement of the whole line, and the variance must be distributed between the several

                                      and the Scateses’ tract, as well as Block 7,
going from the northern line of the Crawfords’ property to the southern line of Block 7, the entire
length of the 190 acre tract.
        Opperman testified that the northern boundary line of Block 7 “is within a couple of feet
of deed calls where it should be.” When the Scateses’ tract was located with reference to the
southern corners of the original partition, its northern boundary as claimed by the Scateses was


               of Shelby County, Texas (Tr.Ct.No. 09CV30,545)

                    THIS CAUSE came to be heard on the appellate record and briefs filed
herein, and the same being considered, it is the opinion of this court that there was no error in the
judgment.

                    It is therefore ORDERED, ADJUDGED and DECREED that the judgment of
the court below be in all things affirmed, and that all costs of this appeal are hereby adjudged
against the appellants, HARRY D. SCATES, JR. AND WIFE, MANDYKorea's leader \colorbox{red!30}{Kim Jong-un}, a change of plan or simple miscommunication, the \colorbox{red!30}{BBC's Korea correspondent Stephen Evans} says.\\
Either way, US Vice-President Mike Pence was undeterred as he spoke aboard the USS Ronald Reagan - an aircraft carrier docked in Japan - during his tour of the region, vowing to "defeat any attack and meet any use of conventional or nuclear weapons with an overwhelming and effective American response".\\
North Korea and the US have ratcheted up tensions in recent weeks and the movement of the strike group had raised the question of a pre-emptive strike by the US.\\
On Wednesday, Mr Pence described the country as the "most dangerous and urgent threat to peace and security" in the Asia-Pacific.\\
His words came after the North held a show of military might


Place different files on different devices

Disk drives operate much more slowly than modern processors or RAM. Often, simply waiting for the disk to read or write pages
is the reason that a database server is slow.

You may improve database performance by putting different database files on different physical devices or drives. For example,
while one disk drive is busy swapping database pages to and from the cache, another drive can be writing to the log file.
To gain these benefits, the drives must be independent. A single disk partitioned into smaller logical drives is unlikely
to yield benefits.

SQL Anywhere uses four types of files: the database file, the transaction log file, the transaction log mirror, and the temporary file. These files should exist on separate drives.

Placing the database file and the transactionincreased from an average of 3% in the 1980s to around 15% today. Some strains contain more than 25% potency

CBD (cannabidiol) CBD does not produce psychoactive adverse effects. Has little affinity for CB1 and CB2 receptors directly. It is believed to modulate the effects of THC throughout the endocannabinoid system which is why the THC/CBD ratio can lead to different responses and adverse effects

Show Fullscreen Figure 1: Evidence for medical cannabis and potential adverse effects There is conclusive or substantial evidence for the use of medical cannabis in treating intractable seizures in Dravet and Lennox-Gastaut syndrome, chemotherapy-induced nausea and vomiting, improving symptoms in multiple sclerosis and treating chronic pain in adults, however the evidence regarding other indications is moderate or limited and there are several potential side effects.

Show


Being a proud Atheist, and a freedom loving INFIDEL AKA "KUFFAR", WE are threatened by the primitive pidgeon chested jihad boys in the medieval east.
FRACK YOU!! SAY US ALL!! Don't annoy the Pagans and Bikers,, it's a islam FREE ZONE!!! LAN ASTASLEM!!!!

The remarkable story of America's 230-year
relationship with the Middle East. Drawing on a vast range of government
documents, personal correspondence, and the memoirs of merchants,
missionaries, and travelers, Michael B. Oren narrates the unknown story of
how the United States has interacted with this vibrant and turbulent region.

[Re:
'The 1,500-Year-Old Strategy for Fighting ISIS':] Having read, "The Art
of War" a couple times, I believe any enemy can be defeated if this is
truly the goal.

S.F.

['ISIS
'Pin-Up Girls' - Before and After':] Unfortunately, ISIS is not a mystery.
These girls knew that ISIS rape andthat he would depart "within months or
weeks." Almost three and a half years have passed, with Assad still
in power, and Davutoglu keeps on making one passionate speech after
another about the fate of Syria.

Turkey's failure to devise a credible policy on Syria has made the
country's leaders nervous. Both Davutoglu and President Recep Tayyip
Erdogan have lately resorted to more aggressive, but less convincing,
rhetoric on Syria. The new rhetoric features many aspects of a Sunni
Islamist thinking blended with illusions of Ottoman grandeur.

http://muslimbrotherhoodinamerica.com/the-course/

The Organization of Islamic Cooperation and its Role in Enforcing Islamic Law

We need to get off Saudi Barbarian OIL!!!!!Support the Canadian OIL Sands,,, and visit,, Ethicaloil.org

The gravity of the existential threat we face from Islamic Jihad is truly of epic proportions. It is essentially a battle pitting free-civilized man against


see how the ability for effective use to be made of patient experience feedback is hindered at both the micro level (of how individual clinicians and teams of staff have difficulty engaging with the data sources) and the macro level (how organizational structures are unwittingly preventing progress). This is played out through various means in a macro sense such as a lack of pan‐organizational learning, the intense focus on the collection of data at the expense of understanding how it could be used and fractured patient experience teams who want to assist ward staff but find this difficult. In a micro sense, a large amount of generic positive feedback is seen as unhelpful with ward staff struggling to interpret various formats of feedback whilst they question the valuelike this every month, so yearly intake would something like a dozen feet of books. What do you actually do with all the books? Do you have an enormous library or do you donate them?
As for the question – Tim Powers for me, I do not know other writers… He has written some excellent books but some bad ones as well. Worth trying out.

This is a strange thing to comment, as I normally don’t pay attention to these posts but…somehow it caught my eye and I realized that one of these books was probably written by an old friend I hadn’t had contact with in around 20 years or so. (The author’s name is the same and my research seems to indicate it is the person in question).


e-liquids in the Roswell Georgia area. Both PG and VG are it is the burning of many of these substances which changes their properties, often for the worse. PG is used as a preservative in and nicotine levels - 0mg, 6mg, 12mg, 18mg, and 24mg nic.

vaporizer pens store

The design and functionality, then the patient will be told to go straight to the emergency room and give treatment advice.

This is the latest version of these browsers for hte best experience. We carry only the best vaporizer pens store pen for your needs. Prices for Premium 100 cartridges. At least with Fin from Walmart you can charge a box at wall and your battery at same time. Lets take a look at the Flower cartridge and explore the plower planexperience, ease of use that experienced hookah swag tumblrrs look for when investing in new hookah swag tumblrs.

Sigelei is doing -nothing- about it aside from trying to lock up, and the G Pen for wax.

I was so desperate and it would take a Novel to explain, with all concerned about everything they ingest, from food to vapour. Hi I just wanted to let you all know thanks. Captain Jack is a popular pipe flavour that bursts with a “reckless Electronic Cigarette - Five Popular Problems It Is Possible To Prevent Menthol, and Mint Tea varieties. Five out of eleven Virgin vapour flavours website and received help from customer support. We aim to provide resellers and the public with of the electronic cigarette. Consult a doctor before use if


Zhuolan

Zhuolan Township is an urban township in Miaoli County, Taiwan.

History
Formerly called Talan ().

Geography
In January 2017, Zhuolan's population was estimated at 17,569.
The township occupies an area of . It receives approximately  of rain each year, mostly during May–June and August–October.

Administrative divisions

The township comprises 11 villages: Fengtian, Jingshan, Laozhuang, Miaofeng, Neiwan, Pinglin, Shangxin, Xincuo, Xinrong, Xiping and Zhongjie.

Economy

Agricultural products
Pears, grapes, starfruits and tangerines are the four main kinds of fruits grown in Zhuolan.

Tourist attractions
 Lixiping Leisure Agriculture Area

Transportation

Bus station

Bus station in the township is Zhuolan Bus Station of Fengyuan Bus. Several city bus routes link Zhuolan with Fengyuan and Dongshi districts of Taichung City.

Highway
Provincial Highway 3 passes by Zhuolan, linking it with Dahu, Miaoli County to the north and Dongshi District, Taichung to the south.

References

External links

 ZhuolanElectrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering.
Efficacy of aligned poly(l-lactic acid) (PLLA) nano/micro fibrous scaffolds for neural tissue engineering is described and their performance with random PLLA scaffolds is compared as well in this study. Perfectly aligned PLLA fibrous scaffolds were fabricated by an electrospinning technique under optimum condition and the diameter of the electrospun fibers can easily be tailored by adjusting the concentration of polymer solution. As the structure of PLLA scaffold was intended for neural tissue engineering, its suitability was evaluated in vitro using neural stem cells (NSCs) as a model cell line. Cell morphology, differentiation and neurite outgrowth were studied by various microscopic techniques. The results show that the direction of NSC elongation and its neurite outgrowth


takes to hold Cuomo accountable to walk the talk and truly make New York a beacon of progressive action for climate justice."

Cuomo outlined his goals for the first 100 days of the next legislative session in a speech hosted by the Roosevelt Institute in New York City. Watch:

Outside the building where the governor was delivering his speech, activists gathered to demand that he move #OffFossilFuels immediately, with many carrying signs condemning the Williams pipeline.

Reporters and activists—including Beauchamp—shared updates from the protest outside Cuomo's speech on Twitter:A true understanding of cellular biology, and of therapeutic effects on pathological conditions under a variety of experimental conditions, requires the noninvasive monitoring of metabolism. Nuclear magnetic resonance (NMR) methods enable metabolism to be studied noninvasively. We have developed a cell perfusion technique allowing the effective application of NMR methods to cell lines grown in culture. This technique consists of embedding cells in a neutral agarose gel thread (0.5 mm) which allows continuous perfusion and rapid diffusion of metabolites into the cells. We are currently applying P31 H1 and C13 NMR to study the metabolism of human lymphocytes and breast cancer (MCF-7) cell lines and the effects of perturbants, such as heat, pH and drugs, upon them. We are also developing sensitive surface coils using the same multi-nuclear


manner and are in compliance.

Ensure the conduct of the study is in compliance with the currently approved protocol/amendment(s), with current GCP guidelines and with applicable regulatory requirements.

Ensure reported data are accurate, complete, and verifiable from source documents. Resolve any discrepancies using a traceable query process.

Disclaimer

The above information on this job description and specification has been designed to indicate the general nature and level of work performed by employees within this job. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities, and qualifications required of employees assigned to this job.Educational Linguists on Parole

Mozilla and Localization Efforts: The Economist’s “Cookies, caches and cows”

The Economist recently published an interesting article, “Cookies, Cache and Cows” from Bamako, Mali on Mozilla’s localization efforts for its web-browser and its (soon-to-be?) mobile operating system. Given my own research on literacy practices in Manding-speaking West Africa, I was excited to see a focus of the article be on the Sahel and Mali’s dominant Manding variety, Bambara. I did some follow-up investigating to better understand Mozilla’s localization (also known as L10n) efforts and in particular those going on for Manding.

Basically, Mozilla has a dedicated website on their wiki for those interested in starting their own localization efforts. This is pretty cool given that my efforts at soliciting information about localization and script-/font-support for Android for


Development of radioactive ion beam production systems for Tokai Radioactive Ion Acceleration Complex-High temperature ion source for short-lived isotopes.
We have developed a new ion source system in the isotope separator on-line at Japan Atomic Energy Agency, for separation of short-lived isotopes produced by proton-induced fission of (238)U. The ion source system is a forced electron beam induced arc discharge version E type ion source with a target container. We successfully operated this system at 2000 degrees C as a result of reductions in volume of the ion source and the target container, introduction of heating method by electron bombardment, and improvement to the heat shield. This new ion source system was tested using (238)U of 640 mg/cm(2) with a proton primary beam of 30 MeV, 350 nA. Releasenot alter that obligation. Bitter had an additional obligation as attorney for the corporation. The record is clear that all negotiations for purchase of the real estate were made on behalf of Gomer's, Inc., which the Smiths and Bitter were then organizing. Bitter cannot profit personally from this transaction nor can he assert personal ownership of the real estate against those toward whom he was bound to exercise the utmost good faith. There is no merit to Bitter's argument.
III. Bitter's Counterclaim for Damages
Bitter filed a counterclaim asking actual damages of $100,000 and punitive damages of $250,000. The gravamen of his claim is that the Smiths were guilty of willful and malicious misconduct purposely designed to "inflict emotional distress on [Bitter] and to cause him other harm and damage."
Bitter


We find no cause to say the trial court abused its discretion in denying Bitter's application.

V. Steve J. Smith's Salary

In rendering judgment, the trial court fixed the salary of Steve J. Smith at $37,500 per year for his services in managing Gomer's Bar. Bitter objects to this as being beyond the scope of the pleadings and not supported by the evidence. We agree with his complaint. We find nothing in either the pleadings or evidence to justify the trial court setting any salary for Smith.
Declaratory judgment actions are subject to the same rules of pleading and proof as other actions. See Hanson v. Lassek, 261 Iowa 707, 711, 154 N.W.2d 871, 873 (1967) (relief must be based on issues as framed by the pleadings and supported by thethe boys excited to run around outside more. One night, we had tons of boys outside playing Zume games until 10:30 pm. What could be better than boys being crazy and having fun?

Note: I have a call in to the maker of the bracelets so that I can provide you with her contact information in case you want to purchase your own. I'll provide contact information for the maker here if I'm able to do so. Stay tuned...

So, farewell until September...

Love,

me

* * * *

Between posts on my website, I document my life on Instagram. You can follow along with me there.


Patreon.

Sign up for our free daily newsletter or weekly newsletter to never miss a story.

Have a tip for CleanTechnica, want to advertise, or want to suggest a guest for our CleanTech Talk podcast? Contact us here.

Latest Cleantech Talk Episodeas floating or immersed in the neutron superfluid in the outer-core, we think of these protons as forming a solid type II superconducting surface, that forms an interface between the liquid outer-core and the inner-crust of the pulsar. We call this region the outer-core surface and guess its thickness to be less than $1\ km$, see Figure 2. The lower critical field and upper critical field of the outer-core surface is given by (2) and (3) respectively.

![For Type II, the magnetization decreases gradually between the lower critical field $B_{c1}$ and the upper critical field $B_{c2}$, allowing magnetic flux lines to penetrate. These flux lines are called magnetic vortices.](Screen2.png){width="90.00000%"}

![This is our proposed pulsar cross-section. The currently accepted cross-section takes a similar form accept it doesn’t have the outer-core surface.


Joseph Murphy invented the potato chip (or crisp, as it is known in this part of the world), the seasoning method, and founded the company “Tayto”, which has grown to become a major manufacturer of chips/crisps and popcorn. The first flavour invented by Murphy was “Cheese & Onion”, which may explain why it is still the most popular (here in Ireland at least). Nowadays, crisps/chips are one of the biggest snacks in the world, with thousands upon thousands of flavours to choose from. And it’s all thanks to Joe being a good ol’ Irish stereotype, and messing around with potatoes.

7. Soda Water

Robert Perceval was born in Dublin on the 30th of September, 1756. Perceval was an exceptionally bright youth, and entered Trinity College, Ireland’s oldest and most highlycondominium at the time, according to police.

Darrant began cleaning his mother's bedroom and hiding evidence the next morning, and even said that he hosted a gathering of friends in the home four days after he killed his mother, police said.

Darrant is a student at Miami's Krop Senior High School, according to police.

The 3-year-old was placed in the custody of Emile's sister, Janet Baker.

"He's fine, I'm taking him to get something to eat," Baker said, as she left the apartment complex Thursday. "We're just praying, that's all."

Zabaleta said police had responded to a domestic disturbance between Emile and the teen last month, and officers were called to the home just last week after the son was reported to have been driving recklessly.

A neighbor who didn't want to be identified


Hn. Therefore, the magnetization of the soft underlayer varies with retaining the value of the saturation magnetization, and the M-H curve does not form a minor loop. This makes it possible to keep the magnetizations oriented in the same direction by the exchange coupling interaction between the soft underlayer and pinning layer.
If the exchange coupling between the pinning layer and the soft underlayer is too strong, the magnetization in the pinning layer may reverse together with the magnetization in the soft underlayer when a magnetic field is applied. Accordingly, a proposal which suppresses magnetization deviation in the soft underlayer by appropriately weakening the exchange coupling force between the pinning layer and the soft underlayer is also known (Jpn. Pat. Appln. KOKAI Publication No. 2003-162807). More specifically, in aIran's crushing response." Israeli government spokesman Mark Regev would not comment on Shirazi's warning other than to say "his words speak for themselves." State Department spokesman Gonzalo Gallegos said such statements by Iran were "unfortunately...not out of the norm." "We continue to stress our desire to resolve this issue diplomatically," Gallegos added. Israel's military sent warplanes over the eastern Mediterranean for a large military exercise in June that U.S. officials described as a possible rehearsal for a strike on Iran's nuclear facilities, which the West fears are aimed at producing atomic weapons. The U.S. Navy's Fifth Fleet, headquartered in the Persian Gulf nation of Bahrain, is responsible for patrolling the Gulf, the Suez Canal and parts of the Indian Ocean. Shirazi is a cleric who represents supreme leader


Ayatollah Ali Khamenei in the guards' naval force. Khamenei has the final say over all state matters. The Guards' Web site also announced late Monday that forces were carrying out a military drill involving "missile squads," but did not say where it was taking place. Iran's guards and national army hold regular exercises two or three times a year, but the statement did not say whether this drill was one of them or if it was a special exercise. Associated Press Writer Nasser Karimi in Tehran, Iran contributed to this report.for DNA repair.[50](#jcmm14064-bib-0050){ref-type="ref"} The role of miR‐15b in cancer drug resistance has been reported in the last decade.[51](#jcmm14064-bib-0051){ref-type="ref"} A recent study[52](#jcmm14064-bib-0052){ref-type="ref"} first pointed out a significant decrease in miR‐15b in OS MDR cell lines and identified *WEE1* mRNA as its direct target. *WEE1* gene codes for a protein kinase to modulate the G2 checkpoint in response to DNA damage. Besides, a restoration of miR‐15b was observed to suppress *WEE1* and partially reverse drug resistance in vitro. By establishing a MDR models of OS, Zhenfeng Duan et al discovered an attenuate resistance to DOX after systemic administration of miR‐15b mimics.

As we all know, intracellular genomic instability is an intrinsic hallmark of tumourigenesis and tumour progression. Some cancer cells rely on a limited set of repair mechanisms for survival. Studies


a pivotal cell cycle phase in response to extracellular cues, and is usually up‐regulated in multiple cancers. After adding quercetin drug, there showed enhanced sensitivity to CDDP, the up‐regulation of miR‐217, and down‐regulation of its target *KRAS* at the level of mRNAs and proteins. This implied that quercetin increased CDDP‐induced cytotoxicity through the miR‐217‐KRAS axis.[60](#jcmm14064-bib-0060){ref-type="ref"} Reduced expression of miR‐138 was assessed in OS tissues and cell lines, and miR‐138 transfection suppressed cell proliferation, induced cell apoptosis, and increased drug responsiveness by binding to *EZH2*.[61](#jcmm14064-bib-0061){ref-type="ref"} MiR‐382 was detected to decrease in OS specimens with chemoresistance compared to those with chemosensitivity. Further study showed that elevated miR‐382 inhibited cell growth and drug resistance via interacting with *KLF12* and *HIPK3*, respectively. Besides, Meng Xu et al confirmed a relationship between miR‐382family and regulates genome stability and chemosensitivity.[74](#jcmm14064-bib-0074){ref-type="ref"} MiR‐34a‐5p was discovered to promote MDR of OS by targeting angiotensin II type 1 receptor (*AGTR1*) in sensitive (G292) and resistant (SJSA1) OS cells, and function of miR‐34a‐5p in drug resistance was further verified in G292 and SJSA1‐derived xenografts.[75](#jcmm14064-bib-0075){ref-type="ref"}

Collectively, these oncogenic or tumour suppressor miRNAs contribute to OS drug resistance by regulating expression of apoptosis‐related genes to avoid cell apoptosis, such as *CCND1* and *BCL2*. Considering that BCL2 is a classic anti‐apoptotic protein that promotes cell survival by inhibiting activation of a caspase cascade, and is associated with several miRNAs in OS chemoresistance, it\'s presumable that BCL2 might be critical for the reversal of MDR in OS. However, further identification and confirmation of the above miRNAs is needed and great efforts


in OS through several molecular mechanisms, and provides insight in creating promising therapeutic strategies by targeting these miRNAs to reverse OS chemoresistance.

CONFLICT OF INTEREST {#jcmm14064-sec-0013}
====================

The authors declare no conflict of interest.

This project was supported by NSFC (81502604), Science and Technology Commission of Shanghai Municipality (14140904000), Doctoral Innovation Fund of Shanghai Jiaotong University School of Medicine (No. BXJ201732).
husband, the only man in your life is me." "I have to go." "I'II see you at school tomorrow." "So long!" "Don't get lost!" "MaIena's up in the employment office." " Looking for a job again?" " But who will ever hire her?" "No one in this town." "I've got a job for her..." "little boy, Iet me get by." "Hey, baby, give a soldier a break!" "Mr Lawyer!" "Your newspaper's upside down!" "Mind your own fucking business!" "Good morning, Signora MaIena, are you well?" "How is your father?" "May I?" "The show's over!" "She's gone now!" "I forgot the key!" "So it's true what people say!" "What's the matter with you?" "You look so strange." "You've poisoned me with your lies." "What lies?" "I've never spoken to


Cadei seemed like such a gentleman." "How could he get mixed up in this?" "Everyone knows she's a home wrecker." "The lieutenant was asking for it!" "She's not from here." "She forgets where she is." "will they go to court?" "Of course, she could go to jail." "He's a married man!" "The dentist needed three stitches in his head." "But the dentist swore at the soldier first." "That's insulting an officer." "We'II all end up in court!" "while we were watching her caboose the lieutenant and the dentist were riding the train!" "She's either going to the lawyer's or the notary's." "Sure, but what will she do with two old men like them?" " Excuse me." " Come in." "Can I help you?" "May I speak to Lawyercrashing into a bus while going the wrong way in the Lincoln Tunnel, Donahue is facing a drunken driving charge in Montana, according to ESPN.com’s Rich Cimini. Donahue is one of several Jets players with legal issues and one has to imagine that his roster spot is in jeopardy.

The Patriots are among the teams interested in former Bills wide receiver/special teams ace Marcus Easley now that he’s back to full health, league sources tell Aaron Wilson of the Houston Chronicle (on Twitter). The Giants also have interest, per Wilson.

]]>1Extra Points: Boldin, Burfict, Mathieu, Saintshttps://www.profootballrumors.com/2018/03/extra-points-boldin-bengals-burfict-cardinals-mathieu-saints-fairley-steelers
https://www.profootballrumors.com/2018/03/extra-points-boldin-bengals-burfict-cardinals-mathieu-saints-fairley-steelers#commentsSun, 18 Mar 2018 03:24:33 +0000https://www.profootballrumors.com/?p=100511Anquan Boldin may not be done playing in the NFL, as he said today that he hasn’t made a decision on the future of his career, according to Jamison Hensley


out three further sets of experiments. First, to verify if hydrating drying leaves would have any impact on shrinkage, they dried leaves following the same procedures they initially followed but then placed the leaves in a damp environment. Second, to ensure that a plentiful source of water to the plant does not have any effect on leaf shrinkage, they hydrated the leaves first and then dried them. Third, some leaves were just left in mud throughout.

Leaves that were hydrated following a period of drying, they found, did not shrink by much. This exciting result was the solution to averting the shrinkage problem. Indeed, if fossilised dried leaves are rehydrated before measurement, the resulting area would be representative of fresh leaf area. The students also found that leaves thatalready spend more time watching online video than broadcast TV, and this will accelerate. Web TV will provide a return path so that content can be more easily interacted with, for example making programmes shoppable. Trends for 201716

17. Twitter has produced new apps for Chromecast, Fire TV Stick and games consoles as part of its NFL live streaming programme, to make it easy to transfer video from the app to TVs. Facebook is also allowing users to put video from the site onto TVs easily via Apple TV, Chromecast and other integrations. Gaming platform Toca Boca has produced a video app, making it a global kids TV channel. The connected TV is now the most popular device for accessing BBC’s iPlayer. WEB TV Trends for 201717

18. The Grand


the Samsung Gear VR, for sale at $2.99 on the Oculus store. BRANDED CONTENT Trends for 201723

24. The level of involvement in branded content will depend on audience expectations and how easily they would accept content from that brand. It’s now easier to make any content and for it to appear anywhere. Brands should consider if there are any existing formats which could be licenced, or create their own. It could also be a good opportunity to expand relationships with brand ambassadors, or find new ones to move into new content areas. IMPLICATIONS Trends for 201724

25. VIRTUAL & AUGMENTED REALITY 5 Trends for 201725

26. 2016 was going to be the year of virtual reality, but the most popular content turned out to be augmented reality. Both VR andcombination of the technology matching expectations, and new consumer behaviours. Augmented Reality is likely to be the more popular in the short term, as far more people have the technology and understand how to make it work. It could well start to take views from video channels – for example for ‘how to’s’ and ‘unboxing’ moments. VR could become huge in home entertainment, but needs to find its own language for users to replace the recognised ways of following films and other video. IMPLICATIONS Trends for 201729

30. CHATBOTS 6 Trends for 201730

31. CHATBOTS Chatbots are automated identities within messaging apps, set up to answer common queries and more. Together with other conversational interfaces like Siri, Cortana, Allo and Alexa (used in Amazon Echo), chatbots are a way of


Marketing will become more about targeting people already known to you, allowing more tailored and personalised messaging. Data use is crucial, as is respecting privacy. All actions carried out by brands need to have a clear consumer benefit. Brands need to have systems that will both manage data securely and also be able to make the data as useful as possible – the newer a company, the more agile and powerful their systems are likely to be. IMPLICATIONS Trends for 201740 TRENDS 2017

41. SPEED 8 Trends for 201741

42. Trends for 201742 Now that most digital activity takes place on a mobile device, speed of access has become a crucial issue. Google, Facebook and others are working on the architecture of pages and apps to ensure that they loadbeing used to generate audiences for future targeting, e.g. people who went to the cinema in the last month, or people who go to festivals Trends for 201749 Finding another pic

50. Proximity is about bridging digital and physical. Location needs to be seen in conjunction with other factors like time and audience – a great location at 8pm on a Friday night might be a terrible location at 11am on a Sunday morning and vice versa. Trends for 201750 IMPLICATIONS Trends for 201750

51. SOFTWARE TO HARDWARE 10 Trends for 201751

52. SOFTWARE TO HARDWARE Companies known for software and being online only, are starting to produce their own hardware products. The reason for this expansion is that they want products specific to their needs, that they can control every


anything to eat or drink in seven days." "Minbari can fast as long as two weeks." "A normal Minbari, yes." "But you're partly human now." "Your system can't handle the stress you're putting on it." "If you don't stop, you're going to hurt yourself." "Look." "Look, I know this is how your people deal with grief, all right?" "You fast." "You purify yourselves physically, spiritually." "But nothing is going to be served by endangering your own life." "Justice is served." "It is my fault that John is gone." "My fault that the Alliance against the Shadows has crumbled." " That the heart has gone out of them." " Delenn..." "For a long time I was afraid his wife might still be alive on Z'Ha'Dum, but I..." "I neverits number is 10 to 20 full-grown oocytes in each ovary, meaning that a number of preantral follicles are unusable in the IVM technique. On the other hand, *in vitro* folliculogenesis from primordial and primary follicles has been studied to produce many eggs in several species \[[@r4]\]. Although many methods have been developed, successful *in vitro* egg production with the live birth of offspring has been limited, especially in livestock animals. More recently, we have succeeded in producing live pups derived from *in vitro/ex vivo* egg production in mice \[[@r5]\]. In this review, I will introduce our recent findings with a brief history of the *in vitro/ex vivo* culture system for follicles and ovaries.

Oogenesis and Folliculogenesis in General {#s2}
=========================================

In the course of fetal development, primordial germ cells (PGCs)


second step, after isolated secondary follicles grown from the cultured ovaries they reached the mature follicle stage after *in vitro* culture for 14 days \[[@r14]\]. Finally, they obtained live pups for the first time by *in vitro/ex vivo* egg production. Considering that it is extremely difficult to isolate and cultivate primitive follicles intact from the ovaries, the 2-step method developed by Eppig's group must be considered a commendable protocol to pave the way for *in vitro/ex vivo* egg production. Unfortunately, although they improved their culture condition in 2003 with an increment in live pups \[[@r15]\], their method has shown a professional problem with difficulties faced by other researchers to reproduce the protocol for a long time ([Fig. 1](#fig_001){ref-type="fig"}Fig. 1.A schematic overview of *in vitro/ex vivo* egg production inresulting in promotion of follicle formation \[[@r5]\]. Further studies are required to establish a chemically defined medium to understand the detail of the mechanisms of oogenesis. Some predisposing factor(s) from follicle development to induction of ovulation may be possibly involved in the success of *in vitro* oocyte growth.

Induction of follicle activation
--------------------------------

At initiation of follicle development, it is revealed that primordial follicles must be activated for starting their development, which is called as follicle activation. The phosphoinositide 3-kinase (PI3K)/Akt pathway is known to play a central role in follicle activation. This pathway is fundamental for cell proliferation, survival, and metabolism. In several studies, PI3K/Akt signaling is shown to be related to follicle activation in livestock animals; for example, in mare ovaries, PI3K/Akt and Janus kinase/signal transducer and activator of


Q:

How can I dump all NVCC preprocessor defines?

I want to achieve the same effect as
gcc -dM -E - < /dev/null

(as described here) - but for nvcc. That is, I want to dump all of nvcc's preprocessor defines. Alas, nvcc doesn not support -dM. What do I do instead?

A:

Instead of -dM, pass --compiler-options -dM to nvcc. You should also add -x cu since the compiler doesn't know the file type of stdin. So your command line would be
nvcc --compiler-options -dM -E -x cu - < /dev/null

email list. On the first Friday of every month, you'll receive a newsletter with information about all of the most important developments from the previous month. You can also join the Komodo Discord server to chat with other community members and the Komodo team.

Join us as we continue to accelerate the global adoption of blockchain technology.


as well allocate packing items, for example, moving boxes and tape, and for added valuation (moving insurance) as really needed. Al's makes very special measures together with fragile or outsized items, which include flat screen tv sets and also chandeliers. Those items often require a customized wooden box, which in turn definitely will get an additional price.

Just how exact will the moving price quote be actually?

By having more than FIFTY (combined) years of knowledge, our sales team congratulates themselves in delivering one of the most specific moving estimations in the marketplace. Our proprietary sales system makes certain that our experts work thoroughly with every potential customer so as to fully understand his/her moving requirements and also to provide a moving estimation which matches those needs. Don't forget todetails on packing and packing supplies look into our blog.

I have certain things which I 'd like to keep, however they won't fit in my new home. Can I store them?

Indeed! #brand: t # supplies complete service storage centers as well as our first class moving professional services. Supposing that your possessions do not actually fit in your new home or apartment, however you are truly only living there merely for a finite period then have plans to transfer to an even bigger house or apartment or maybe you need to hang on to the belongings with regard to family and friends, use of our storage facilities is a hassle-free, risk-free option. Consult your move coordinator with respect to additional information about this service.

Exactly what can I do


produced by different positions of the layer determining box or by moving the second, third, etc. element of the box-list to the beginning of the list before starting the method for generation. From the different stowage plans a stowage overseer can choose a suitable plan. This known method has some drawbacks, e.g. that only within each layer a certain optimisation of the packing density can be reached and that is needs human intervention for selecting a suitable one from the different generated stowage plans. In addition, the calculations are always to be carried out again after positioning a new object.Pages

Tuesday, June 26, 2012

Book Review: The Truth About the Lordship of Christ

In The Truth About the Lordship of Christ, pastor and author John MacArthur discusses God's sovereignty, our submission as believers, assurance of salvation, and the characteristics of a believer's life.

I like John MacArthur. I've read some of his other books, and I've also listened to some of his sermons. However, while reading this book, I found myself fighting to stay focused. I felt like there was not very much coherency between the different chapters and the sub-headings within each chapter.

There were a few points that MacArthur made that I found myself scratching my head in a bit of confusion and wondering if his points were truly Biblical. And this really surprised me. However, for the most part


Xenopus neurites. Axonal plasma membrane was found to flow anterogradely with the rate equal to approximately 30% of the rate of neurite elongation. Our results suggest that the "growth from the tip" pattern of neurite elongation may coexist with transport of new membrane components along plasmalemma by anterograde membrane flow.This invention relates to a method and apparatus utilizing digital logic for minimizing visual perception of the raster lines on a photographic film recording of a video or TV monitor picture. The principles of operation of a raster erase method utilizing analog rather than digital components, are disclosed in U.S. Pat. No. 4,096,530 issued to J. S. Plugge, William H. Wesbey, and James E. Blake and assigned to the assignee of the present invention. The disclosure of U.S. Pat. No. 4,096,530 is incorporated herein by reference.
As is well known, when a viewer is closely viewing a cathode ray tube video monitor, the horizontal raster lines can be seen on the face of the picture tube. However, if the viewer is far enough away from the face of the


at the bottom of the screen, and the retrace bar as a visible black bar between the top and bottom parts of the screen. The picture continues to "roll" with increasing speed as the frequency of vertical sync pulses increases from the normal 60 cps. At the normal frequency, successive frames overlap. Thus, it can be seen that, if the vertical sync pulse is delayed in a next frame by a slight amount, such next frame appears to move up from the screen position of the original image. This is described in the art as "vertical roll" as described above wherein a large horizontal black bar appears across the screen and separates the bottom of the original image (appearing at the top of the "rolled" screen) from theAt the House Intelligence Committee’s impeachment hearing, Rep. Adam Schiff denied knowing the identity of the whistleblower even though his office had prior contact with the person (which Schiff, of course, didn’t disclose at the time).

However, memesmith Carpe Donktum found the whistleblower. It turns out he’s been right in front of everybody the whole time. Click play, and then, as they say, “wait for it”…

LOL. Perfect. Better run it by some media firefighters first though:

Can I get a fact check on this @brianstelter @acosta? Looks doctored https://t.co/08VvRfzGvH — Carpe Donktum? (@CarpeDonktum) November 13, 2019

Schiff just makes it too easy!

? at first I was like wtf is that whistle. Omg this is brilliant — milehigh ??? (@milehigh20) November 13, 2019

My friend Carpe does it again… Awesome stuff. https://t.co/piOAlycmbL —


Microfibrillated cellulose - its barrier properties and applications in cellulosic materials: a review.
Interest in microfibrillated cellulose (MFC) has been increasing exponentially. During the last decade, this bio-based nanomaterial was essentially used in nanocomposites for its reinforcement property. Its nano-scale dimensions and its ability to form a strong entangled nanoporous network, however, have encouraged the emergence of new high-value applications. In previous years, its mode of production has completely changed, as many forms of optimization have been developed. New sources, new mechanical processes, and new pre- and post-treatments are currently under development to reduce the high energy consumption and produce new types of MFC materials on an industrial scale. The nanoscale characterization possibilities of different MFC materials are thus increasing intensively. Therefore, it is critical to review such MFCcold autumn nights. One such dish is Oden. Oden is a hearty stew that can be cooked over several days or in a few hours (depending on the cook) and is also a big hit in the winter season. It is quite easy to make and the ingredients can be ordered online, or at Japanese supermarkets (if you are lucky to have one in the area where you live). It is a savoury dish filled with flavours, due to its ingredients that usually include yam, taro, fish cake, hard-boiled eggs, and mushrooms. Some of these ingredients may sound like weird combinations to us Westerners but it is a beautiful yummy dish that deserves a chance to be sampled. If you love one-pot winter dishes, Oden may just be


output at a different voltage. The storage may be in either magnetic field storage components (e.g. inductors, transformers) or electric field storage components (i.e. capacitors) or a combination of both. This conversion method is more power efficient (often 75% to 98%) than a linear regulator, for example. This efficiency is beneficial to increasing the running time of battery operated devices.
Among the different DC-to-DC converter topologies, the LLC (Inductor Inductor Capacitor) converter has attracted substantial attention recently because of its high efficiency, smooth waveform and high power density. The high efficiency of the LLC converter is due to the use of zero voltage switching (ZVS). ZVS reduces switching loss which in turn improves the efficiency of the LLC converter.
An LLC converter operates in a resonant mode. During a resonant

BlackBerry Announces $1B loss, 4500 layoffs and shifts away from consumer market - Brajeshwar
http://venturebeat.com/2013/09/20/blackberry-bombs-announces-1b-loss-4500-layoffs-cutting-operating-costs-by-50-shifting-away-from-consumer-market/

======
contextual
If I understand correctly, this billion dollars is a writedown in inventory
and not cash. It's for product that's only been in the channel for a few
months. Good product like the Z10.

Why? This lowers the price of the corporation so it can be taken private. They
are making BlackBerry as affordable as they can, as quickly as they can.

I have a Q10 and I love it. I had a Z10 and I wish I still had it. Great
smartphones with the best OS I've ever used. And just recently they announced
the "flagship" Z30 to get users excited: [http://www.techcentral.co.za/meet-
blackberrys-new-flagship-t...](http://www.techcentral.co.za/meet-blackberrys-
new-flagship-the-z30/43754/)

BlackBerry will be around for a long time, but they will be leaner, wiser and
with a genuinely great product line for


segments do.

If they get small enough I suspect they'll be able to sustain operations. It
will probably become quite a lucrative consulting niche.

~~~
brianbreslin
But how small of a consulting biz? would this be something IBM then acquires?

~~~
GrinningFool
I'm not sure about for them - I meant for third parties :) Pretty much any
level of adoption in the enterprise will necessitate development of LOB apps.
Some of those enterprises will do it in-house, but others will not. With BB10
being scarce in the consumer world, there will not be a ton of talent with
experience in building for it.

Random musings on the daily ups and downs of life as a freelance journalist and editor

Hacked off. That's me. Mostly, anyway. I'm a wordsmith and I get frustrated, grumpy, ranty and angry at times. I also smile a lot when things are going well. Here's where I reflect on 30-odd years in my trade...

30 May 2008

BBC Magazine published an interesting article on the comeback of the typewriter today. Reading it, I was flushed with nostalgia. You see, I still own a typewriter. Years ago, when I began hacking for a living, I would hammer out copy on a huge Remington in the office. It weighed a ton and was a frightening beast. The keys would stick and my hands would get filthy with grease and dust and the


useful contact.

TV/radio: I watched the first episode of The Invisibles on Thursday, expecting it to be like Hustle - stylish and witty. It wasn't. It was dire. What a waste of a talented cast. I missed two episodes of The Apprentice while away, except I didn't really miss it - this year's crew have failed to excite me yet and most of them seem fairly indistinguishable so far. Until Wednesday, when I saw what a cow Jenny Celery is, what a bully Lee is and what a pointless pin-up Alex is. Over in Ambridge, not much is happening as usual, but that's why I like it - it ambles along slowly and undemandingly, yet is compulsive listening. Ross the Red-Top Wannabe is back digging for dirt again anddrive and assuming I must have been nicked for drink-driving. So now I'm in the habit of tacking "for medical reasons" on to the end of that particular sentence.

Interestingly, over the last couple of years I have been stunned to discover just how many of my freelance colleagues working in journalism and editing also have disabilities. Freelancing is clearly an attractive option when you have health and mobility issues to take into account.

* This is a "Blogging Against Disablism Day 2008" post. Read more here.


in shade-tolerant T. cordata, shoot growth was weakly related to PPFD and more was invested in long shoot growth on a leaf area basis compared with P. tremula. However, this extension growth was not directed and may serve as a passive means of avoiding self-shading. This study supports the hypothesis that, for a particular species, allocation patterns and crown architecture contribute as much to shade tolerance as leaf-level photosynthetic acclimation.is best for your pool, and setting it up isn’t all that difficult either. All it takes is a little determination and a bit of effort and your pool will cleaning itself for you!
During fall, the weather start taking a cold turn and you find yourself getting sadder and sadder the further from warm weather you get. If you’re not ready to give up on your swimming pool for the year, then you’re probably on the lookout for a means of heating your pool through the cold seasons. Luckily for you, there are easier ways of heating your pool without shooting up your electricity bill by ungodly amounts. You can easily get swimming pool solar heating set up so that you can enjoy the warmth of your pool


The Sportsmen’s Heritage and Recreational Enhancement (SHARE) Act would allow hunters to kill and hurt vulnerable animals.

If passed, this bill would endanger wolves, bald eagles, other protected birds, and would allow trapping and hunting on public lands where it isn’t currently allowed.

Gray wolves went nearly extinct a long time ago before being protected under the Endangered Species Act in 1974.

This act would delist them as endangered and allow them to be hunted again, which will all but certainly put them at risk of extinction again when their population has just recovered in recent years.

Wolves are killed with insanely cruel methods such as snares, steel-jawed leg traps, and in some places it’s even legal to run over them with snowmobiles and other vehicles.

Wolves are killed with insanely cruel methods| grep python, with the following results:
$ ps -eaf | grep python
immotest  1489  1444  0 14:33 pts/1    00:00:00 venv/bin/python ./run.py
immotest  1497  1489  1 14:33 pts/1    00:00:00 /home/kramer65/mysite/venv/bin/python ./run.py
immohie+  1510  1374  0 14:34 pts/0    00:00:00 grep --color=auto python

A:

I already suspected it had something to do with the Flask dev server which spawns a new process to be able to restart itself upon code changes. I had added watchdog to requirements.txt because I use it to sync code from my laptop to my Linux dev server.
The Flask dev server works with Watchdog, but for some reason on this machine it wasn't. After removing watchdog from the server everything works fine again. I


a. Field of the Invention
The present invention relates generally to clips and similar gripping devices, and, more particularly, to a thumbscrew-operated clip for gripping the edges of tarps formed of plastic, cloth or other flexible sheet material.
b. Related Art
The problem of how to secure a tarp against environmental conditions is one of long standing. By their very nature, tarps are intended for use as protection against the weather and are therefore often subjected to high winds. This is true not only in stationary installations, but also where a tarp is used to cover a load on a moving vehicle, such as over a truck bed or rail car.
For years, many tarps have been provided with grommets along their edges to provide attachment points for ropes or other hold-downan indefinite slowdown.
As people honour social distancing directive and stay home, it means the Jua Kali people have no markets to trade off their wares in.
This, coupled with a depressed economy where generally money was not flowing points to a possible total crumble of the industry.
But Muteti insists they have to keep going, with any effort to completely close the markets translating to the starvation of millions of Kenyans who depend on daily wages to eat.
Recently, Muteti visited Kamukunji Market in the company of Ministry of Health officials to demonstrate to the artisans on how to maintain basic sanitation.
There, they demonstrated handwashing with soap and running water, social distancing and basic respiratory hygiene. This was then to be shared in other markets in other parts of the country.
But


was a genuine issue of fact requiring trial, but rather proceeded to evaluate the evidence as if the proceeding were a trial on the merits.  Under the circumstances presented by this case, further proceedings ought to be conducted before a judicial officer not involved in the earlier proceedings.

60
Finally, we emphasize that our analysis has been limited to whether it was appropriate to grant summary judgment for the appellees.  We stress emphatically that we intimate no opinion with respect to the merits of the dispute.

Conclusion

61
For the foregoing reasons, the judgment of the district court is affirmed with respect to the dismissal of the count under the Illinois Anti-Dilution Statute.  It is vacated insofar as it denies the appellee's motion for sanctions;  it is reversed andits contention that the Illinois Anti-Dilution Act may be applied between direct competitors.  We note only that these cases both antedate EZ Loader Boat Trailers, Inc. and are against the clear weight of current Illinois authority.  Accordingly, they are not controlling on American's standing to bring this claim

14
 The traditional preliminary injunction test used by this court requires:  1) no adequate remedy at law, 2) irreparable harm, 3) the harm to the movant if not granted outweighs the harm to the nonmovant if granted, and 4) consideration of the public interest.  Schwinn, 870 F.2d at 1181


delay on Tx and Rx for CPU port
	 * Ref: sec 4.7.2 of chip datasheet
	 */
	miiphy_write(name, devadr, MV88E1116_PGADR_REG, 2);
	miiphy_read(name, devadr, MV88E1116_MAC_CTRL2_REG, &reg);
	reg |= (MV88E1116_RGMII_RXTM_CTRL | MV88E1116_RGMII_TXTM_CTRL);
	miiphy_write(name, devadr, MV88E1116_MAC_CTRL2_REG, reg);
	miiphy_write(name, devadr, MV88E1116_PGADR_REG, 0);

	/* reset the phy */
	miiphy_reset(name, devadr);

	printf("88E1118 Initialized on %s\n", name);
}

/* Configure and enable Switch and PHY */
void reset_phy(void)
{
	/* configure and initialize PHY */
	mv_phy_88e1118_init("egiga0");

}
#endif
reason we're in the finals is because I'm carrying you." "You keep stopping everywhere to buy souvenirs." "And I swear, if Jeff wasn't at Dick's bachelor party -- ...BearandRick." "He's a survival expert, I'm a travel expert." "We've won every leg so far." "It hasn't been particularly enjoyable." "...YeagerandJohnny." "My name, and I hope it's trending right now, is Yeager Chillax." "It is not trending." "Oh, but Dannon Yogurt just followed me!" "I like to kick ass and jam clam with my man Johnny Bananas." "Yo, I've won MTV's "The Challenge" six times." "Now I own more yellow XTERRAs than anyone in the whole world." "Boom!" "Vote for us." "Is there -- Is there voting on this?" "Andfinally, MeredithandJustin, hersonwhowent toheavenandback." "As a single mom who runs her


so Yeager Chillax." "Angels are gonna help us fly the plane!" "ALL:" "Aww." "Hey!" "I'm still hogging the camera here!" "What, that kid's special because he died for a second?" "Bananas can kiss his own tip!" "Tell 'em, Bananas!" "I could suck it, but I never do." "HOST:" "Once in Bangkok, teams willhittheirfirstdetour, wherethey'llhavetochoose betweenyakandback." "Here,theymustherdyaks  orhaveafullThai massage beforetheycan continueracing." "Doesn't a massage sound nice, a little romantic couple time?" "We watched "Rush Hour 3" on the plane." "I think I'm done wooing you." "I bet we can rip through that yak herding." "Based on what?" "Hurry up!" "(cheers and applause)" "Dude, they love us!" "The cameras, the attention -- they're finally on us!" "(crowd shouting "Justin!")" "In heaven, you can fart colors!" "(cheers and applause)" "ThisSmall UV Printer – Several Specs to Look For if Contemplating Deciding to Buy a Small UV Printer.

One of the most popular options that come with latte art printer recently has become the introduction of cylindrical devices for printing things like water bottles. I believe that cylindrical tools are offered as an choice for every printer with sufficient throat to fit one. This brings at the very least two questions in the light: One, how user-friendly may be the software for starting a cylindrical job and, two, should i need another specialized ink? Although metal water bottles could be successfully printed with a lot of UV inks, you will discover a different story with plastic bottles that could be squeezed. These require a flexible ink, so some of


the printer manufacturers now provide an ink that stretches around 200 percent.

The flexible ink option opens up other applications, like printing banners. Magnetic signs are another possibility and some manufacturers have built their printers so there are actually no paramagnetic (steel) parts that could affect printing a magnetic material.

Together with the large number of inks available, a significant decision you need to make is determing the best ink for the applications. Inks can’t easily be changed so once an ink is selected you will be just about saddled with it to the duration. Ink changes are possible in the event you thoroughly clean the printer, but this could be time-consuming and it is not recommended for job-to-job use.

Inks are often specific to the manufacturer, and are therefore paperReuters

US farmers are slamming Trump's tariffs after he announced in a tweet that an additional 10% of tariffs would be placed on Chinese goods, on top of the 25% already in place.

"Trade policy is not a game — it has real and serious consequences for rural America," said the president of the National Farmers Union to Bloomberg.

Markets Insider reported earlier this week that China had already been looking to other markets such as Brazil for agricultural goods in light of the trade dispute.

View Markets Insider for more stories.

US farming associations have hit out at President Donald Trump's tariffs saying that "Trade policy is not a game" and that "farmers and ranchers could be dealing with the fallout for decades to come."

Roger Johnson, president of the National Farmers Union,


the nation's second-largest general farm organization, told Bloomberg that Trump's latest tariffs would hurt American farmers — a large part of his own voter base.

"Trade policy is not a game — it has real and serious consequences for rural America," Johnson told Bloomberg, adding "Immediately after President Trump tweeted his tariff threats, already low commodity prices slipped yet again, but the long-term implications for our country's reputation as a reliable trading partner are likely to be even more damaging."

Trump announced in a Tweet that he would be stepping up tariffs adding 10% on top of the already 25% tariff on Chinese goods. Markets plunged on the news.

"It may take President Trump just a few minutes to write 280 characters, but family farmers and ranchers could be dealing with(dbcAMP) stimulation of aldosterone production in a concentration-dependent manner. PP2 did not affect cell viability at any of the concentrations tested. Moreover, time course studies using PP2 (10 microM) for 6, 12, 24, and 48 h revealed a time-dependent inhibition of aldosterone production. Inhibition by PP2 (0.3-10 microM) was also observed for the metabolism of 22R-hydroxycholesterol (22R-OHChol) to aldosterone in H295R cells. Since 22R-OHChol is a substrate for cytochrome P450 side-chain cleavage enzyme (CYP11A) that does not require steroidogenic acute regulatory (StAR) protein for transport to the inner mitochondrial membrane, these results suggest that PP2 inhibition occurred beyond the rate-limiting step in aldosterone synthesis. Genistein, a non-specific tyrosine kinase inhibitor also blocked aldosterone production, but the inhibition was the result of a non-specific effect on 3beta-hydroxysteroid dehydrogenase (3betaHSD).


i = 4*o + 2*i - 17. Which is the nearest to o?  (a) 0.1  (b) w  (c) -2/3
b
Let z = -4.06 + 3.3. Let t = z - -0.26. Which is the nearest to t?  (a) -5  (b) 2/7  (c) -0.5
c
Let l = -125 + 119.06. Let k = -0.06 + l. Let j = 1.51 - 2.51. Which is the nearest to j?  (a) -2  (b) k  (c) 2/23
a
Let c = 16.1 - 1.1. Let l = -15.2 + c. Suppose 8 + 1 = 3*u. What is the closest to l in -1/2, -0.4, u?
-0.4
Let g = 20 - 19.5. Let p(w) = w**2 - 2*w + 1. Let j be p(4). Suppose -3 = -2*o- j. Which is the closest to 1?  (a) 1/6  (b) o  (c) g
c
Let o = -134 - -134.5. Let d = -0.7 - 0.8. Let y = o + d. Which is the closest to -0.1?  (a) -4  (b) y  (c) -4/7
c
Let h be (28/8 + -4)*-58. Let o = h - 26. Let x be (-6)/(-15) - 16/(-10). Which is the nearest to -0.1?  (a) -0.2  (b) x  (c) o
a
Let t = -0.6 + -2.4. Let q = 0.0311 - 5.0311. Let w = 0.3 + -0.2. Which is the closest to 3/4?  (a) w  (b) q  (c) t
a
Let j = 17/93 - 1/62. Let x = -45.46 - -0.46. Let b = x


he has, I think is counter-productive.”

In his third outing of the spring, David Price was nearly as efficient as Lackey, throwing four scoreless innings of one hit ball while striking out five and walking one.

That was a lot better than five days ago, and a lot better than 10 days ago,” Price said, referring to his first two spring starts. “It was good to get out there and to be able, not only be efficient but to execute, for the most part when I was out there on the mound.”

Yoenis Cespedes returned to the Tigers lineup after missing a couple games with a quadriceps injury, and showed little sign of rust. He sent a pitch from Lackey to the right field warning track in the second inning andAll relevant data are within the manuscript and its Supporting Information files.

Introduction {#sec001}
============

Alzheimer's disease (AD) is the most common form of dementia, the sixth leading cause of death in the US, and the fourth leading cause of death in African Americans \[[@pone.0231765.ref001]\]. AD is characterized by extracellular β-amyloid deposition in the brain \[[@pone.0231765.ref002]\], followed by intracellular neurofibrillary tangles of hyperphosphorylated Tau proteins, accompanied by neuronal loss \[[@pone.0231765.ref003]\]. All attempts to reduce amyloid deposition in dementia have been unsuccessful in preventing or slowing neurodegeneration \[[@pone.0231765.ref004]\] and cognitive function, thus efforts are now focused on treatment at earlier stages of pathology \[[@pone.0231765.ref005]\]. However, methods to select patients with early AD pathology are limited by incomplete understanding of early pathophysiology and lack of biomarkers to predict the onset of AD in


Deuterated DCA standards (succinic acid-d~4~, adipic acid-d~4~, suberic acid-d~4~, sebacic acid-d~16~) were purchased from Cambridge Isotope Laboratory.

Dicarboxylic acid extraction and derivatization {#sec007}
-----------------------------------------------

The extraction protocol was adapted from Costa *et al* \[[@pone.0231765.ref039]\]. Briefly, 500 μL urine and 100 μL deuterated internal standard mixture at 20ng/μL in ethanol was diluted to 1 mL with brine solution and acidified to pH 2 with 3 drops of 1 M HCl. Then, the urine was extracted 3 times with 3 mL ethyl acetate. The combined organic layer was dried with sodium sulfate before decanting and drying under a stream of nitrogen at 45°C. Once dry, the extracted DCA were converted to dipentafluorobenzyl esters by adding 25 μL of 5% v/v PFBBr and 25 μL 10% v/v DIPEA in anhydrous acetonitrile to the residue.effects from physiological variables in our study, we collected urine "spot" samples after a 12 hour overnight fast, excluded the one individual that had proteinuria (\> 300 μg/mL), and normalized individual DCA levels to the total amount of DCAs measured, in units of percent. Specificity of clinical or biochemical correlation will require replication by other labs, testing in different populations, longitudinal studies, and matching with other biomarkers and clinical outcomes, including brain pathology. Finally, the complex sample preparation and GCMS methods have more variability than simpler assays such as ELISAs. These initial results of C3-10 DCAs may encourage further research of additional urine lipid species. Our methods section reports our reproducibility within different preparations of the same sample, as well as for samples taken on consecutive days from


authors are employed by a commercial company: Cipher Biostatistics & Reporting.

1.     Please provide an amended Funding Statement declaring this commercial affiliation, as well as a statement regarding the Role of Funders in your study. If the funding organization did not play a role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript and only provided financial support in the form of authors\' salaries and/or research materials, please review your statements relating to the author contributions, and ensure you have specifically and accurately indicated the role(s) that these authors had in your study. You can update author roles in the Author Contributions section of the online submission form.

Please also include the following statement within your amended Funding Statement.

"The funder provided support inthe form of salaries for authors \[insert relevant initials\], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section."

If your commercial affiliation did play a role in your study, please state and explain this role within your updated Funding Statement.

2\. Please also provide an updated Competing Interests Statement declaring this commercial affiliation along with any other relevant declarations relating to employment, consultancy, patents, products in development, or marketed products, etc.

Within your Competing Interests Statement, please confirm that this commercial affiliation does not alter your adherence to all PLOS ONE policies on sharing data and materials by including the following statement: \"This


does not alter our adherence to  PLOS ONE policies on sharing data and materials." (as detailed online in our guide for authors <http://journals.plos.org/plosone/s/competing-interests>) . If this adherence statement is not accurate and  there are restrictions on sharing of data and/or materials, please state these. Please note that we cannot proceed with consideration of your article until this information has been declared.

Please include both an updated Funding Statement and Competing Interests Statement in your cover letter. We will change the online submission form on your behalf.

Please know it is PLOS ONE policy for corresponding authors to declare, on behalf of all authors, all potential competing interests for the purposes of transparency. PLOS defines a competing interest as anything that interferes with, or could reasonably be perceived as interfering with,the full and objective presentation, peer review, editorial decision-making, or publication of research or non-research articles submitted to one of the journals. Competing interests can be financial or non-financial, professional, or personal. Competing interests can arise in relationship to an organization or another person. Please follow this link to our website for more details on competing interests: <http://journals.plos.org/plosone/s/competing-interests>

**Comments to the Author**

1\. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer \#1: Yes

Reviewer \#2: Yes

\*\*\*\*\*\*\*\*\*\*

2\. Has the statistical analysis been performed appropriately and rigorously?

Reviewer \#1: Yes

Reviewer


SIM analysis. Specifically, whether some other DCAs such as smaller than C4 or bigger than C 10 were detected in urine, or there is no statistical differences for these DCAS between AD and cognitively healthy groups. The recovery yield for C3 and DCAs greater than 10 turned out to be poor and we were not able to optimize the method within these experiments. The values for C6, and C10 were of good quality but they were not significantly different between the groups. We concentrated on those DCAs that we found to be different between CH and AD and which yielded good quality data. We have started to look at larger DCA's with a new approach, but this is beyond the scope of this manuscript. We used a triplequad GCMS and used the SIM approach because the DCAs all fell apart under conditions we tried. As we mention in the limitations section, we state clearly that a simpler assay will be needed for widespread use, but we hope that these initial results that we report will stimulate efforts to look further at urine as a biomarker with potential for screening of pre-symptomatic AD.

3\. However, some details of the analysis method may be ignored. For example, gas chromatographic methods coupled with mass spectrometry is widely used for the detection of dicarboxylic acids, but the efficiency and stability of reaction products and several derivatization agents may be different, so the detection limit (LOD) and relative standard deviation (RSD) of C4,C5... C10 should be given, 0therwise, the relationship between


host material of the second emitting layer is a monoazine derivative having a higher electron transporting performance than a host material of the first emitting layer. Luminescent materials of the first and second emitting layers are the same ortho-metalated complex.
In contrast, in the organic EL device of non-Patent Literature 1, luminescent materials of the first and second emitting layers are different ortho-metalated complexes (see device A in FIG. 1).          while (to.results.next()) {
                String QueryStr = String.format("INSERT INTO Table (A,B) VALUES (%s,%s)",to.results.getString(1),to.results.getString(2));
                from.sql.executeQuery("QueryStr");
            }
            to.connection.close()
            from.connection.close()

        } catch (Exception ex) {
            ex.printStackTrace();
        { finally {


    public Statement sql;

        public Database(int _id, String _server, String _database) {
            id = _id;
            server = _server;
            database = _database;
            String connectStr = String.format("jdbc:driver://SERVER=%s;port=6322;DATABASE=%s",server,database);
            connection = DriverManager.getConnection(connectStr);
            sql = connection.createStatement;
        }
    }
}

I keep getting a "Connection object is closed" error whengeneralPath;
g.setPaint(paint);
g.setStroke(stroke);
g.draw(shape);
g.setTransform(transformsStack.pop());
g.setComposite(AlphaComposite.getInstance(3, 1.0f * origAlpha));
transformsStack.push(g.getTransform());
g.transform(new AffineTransform(1.0f, 0.0f, 0.0f, 1.0f, 0.0f, 0.0f));
// _0_6
if (generalPath == null) {
   generalPath = new GeneralPath();
} else {
   generalPath.reset();
}
generalPath.moveTo(45.2f, 1.0f);
generalPath.lineTo(72.3f, 27.7f);
generalPath.lineTo(45.2f, 27.7f);
generalPath.lineTo(45.2f, 1.0f);
generalPath.closePath();
shape = generalPath;
paint = new LinearGradientPaint(new Point2D.Double(45.32400131225586, 74.18399810791016), new Point2D.Double(58.87099838256836, 87.73100280761719), new float[] {0.0f,0.35f,0.532f,0.675f,0.799f,0.908f,1.0f}, new Color[] {new Color(255, 255, 255, 255),new Color(250, 251, 251, 255),new Color(237, 241, 244, 255),new Color(221, 229, 233, 255),new Color(199, 211, 218, 255),new Color(173, 189, 199, 255),new Color(146, 165, 176, 255)}, MultipleGradientPaint.CycleMethod.NO_CYCLE, MultipleGradientPaint.ColorSpaceType.SRGB, new AffineTransform(1.0f, 0.0f, 0.0f, -1.0f, 0.0f, 102.0f));
g.setPaint(paint);
g.fill(shape);
g.setTransform(transformsStack.pop());
g.setComposite(AlphaComposite.getInstance(3, 1.0f * origAlpha));
transformsStack.push(g.getTransform());
g.transform(new AffineTransform(1.0f, 0.0f, 0.0f, 1.0f, 0.0f, 0.0f));
// _0_7
if (generalPath == null) {
   generalPath = new GeneralPath();
} else {
   generalPath.reset();
}
generalPath.moveTo(45.2f, 1.0f);
generalPath.lineTo(72.3f, 27.7f);
generalPath.lineTo(45.2f, 27.7f);
generalPath.lineTo(45.2f, 1.0f);
generalPath.closePath();
shape = generalPath;
paint = new Color(0, 0, 0, 0);
g.setPaint(paint);
g.fill(shape);
paint = new Color(113, 145, 161, 255);
stroke = new


the search might fail to operate properly, requiring each client to rewrite or update their XML instructions for accessing that changed page and simulating user entry of a search.

What is needed is an improved search using subdomains and other techniques.

BRIEF SUMMARY OF THE INVENTION

A search system according to embodiments of the present invention analyzes search queries to determine if they are to be routed to subdomains and presents results include sponsored hits sponsored on a subdomain by subdomain basis.

Other features and advantages of the invention will be apparent in view of the following detailed description and preferred embodiments.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a block diagram of a search system according to embodiments of the present invention.

FIG. 2 is a block diagram showing elements of the searchcorpuses might overlap such that some content or information is present in more than one subdomain corpus. Throughout this disclosure, where there are multiple instances of an object and the number of instances is not critical, the instances are numbered from “1” to “N” with the understanding that the value of N need not be identical from use to use, unless otherwise indicated. For example, N is used as the number of subdomains, but that number might vary from example to example. It should also be understood that nothing here requires that all instances be used.

The interconnections between various systems need not be described in detail, as such methods of interconnections can be accomplished using well-known techniques. For example search client 110 might be a personal computer running


search results page would be more focused as a result. The matching inserts might not include a link for yellow page searches for the search term and the sponsored links and advertisements can be selective. Thus, one sponsor might opt to purchase sponsored link placements for the term “camera” under the auction subdomain, but not under a general search or a search in the yellow pages subdomain. In this manner, advertisements and sponsored links can be more focused. This is useful, for example, if an advertiser wants to reach users that are looking to buy or sell cameras at auction, but not if that user is looking for the location of a local camera store.

Layout area 302 displays matching inserts 214. In this example, those matching inserts are“Inside Yahoo!” links that relate to the search term. Layout area 304 displays directory matches, which are matches from a subdomain encompassing the Yahoo! directory, a hierarchical arrangement of topics and links associated with those topics at various levels in the hierarchy. Layout area 306 displays sponsored matches, which are hits provided to the user based on sponsorship of particular terms.

In some browser or other input device configurations, the user is provided with a toolbar for entering searches, setting preferences, selecting/editing personalize hint sets (e.g., a list that might be a subset of the list shown in Appendix A), and jumping directly to some services without a search, such as a main mailbox page. As another example, a search query for “map Sunnyvale 94089” might not require a


from preferences).

For such localized searches, the user might be given a selection of whether to disable the “locality” of the search to get a generic search, pick another location, etc. In one variation, the user is returned both local search results and generic search results, with display elements (color, offset, labels, etc.) to distinguish them from each other.

Where searches can be done over areas having different languages or dialects, the location information might be used to automatically spell check or translate or otherwise adjust the search query. For example, if the search query “boot organizer” is entered and the search is detected as coming from North America, it might be disambiguated to “shoe storage organizers”, whereas is the search is detected as coming from the United Kingdom orMain

Fredericksburg: City of Hospitals – 2017 special event

A Special History Evening – “Fredericksburg: City of Hospitals “, August 10, 2017

St. George’s Episcopal’s Docents are pleased to provide a second evening event following up on “War Comes to the Church” lecture last year with Steward Henderson.

This year we have a “double-header” on August 10 with Dr. Jon Willen at 6pm for a medical renactment and John J. Hennessy at 7pm for a lecture. The topic is “Fredericksburg: City of Hospitals.” The evening promises to provide the audience a realistic view of medicine in the Civil War and how it played out in Fredericksburg in several locations, including St. George’s.

Dr. Jon Willen is a retired infectious disease specialist currently residing in Washington, DC. He received his medical degree from Wake


Works thereof.
 *
 *       "Contribution" shall mean any work of authorship, including
 *       the original version of the Work and any modifications or additions
 *       to that Work or Derivative Works thereof, that is intentionally
 *       submitted to Licensor for inclusion in the Work by the copyright owner
 *       or by an individual or Legal Entity authorized to submit on behalf of
 *       the copyright owner. For the purposes of this definition, "submitted"
 *       means any form of electronic, verbal, or written communication sent
 * conditions
 *       of TITLE, NON-INFRINGEMENT, MERCHANTABILITY, or FITNESS FOR A
 *       PARTICULAR PURPOSE. You are solely responsible for determining the
 *       appropriateness of using or redistributing the Work and assume any
 *       risks associated with Your exercise of permissions under this License.
 *
 *    8. Limitation of Liability. In no event and under no legal theory,
 *       whether in tort (including negligence), contract, or otherwise,
 *       unless required by applicable law (such as deliberate and grossly
 *       negligent acts) or agreed to in


Embodiments of the present invention generally relate to networking and more specifically to redirecting content requests.
A user may send a request for content. Typically, the request is routed to a first data center. A content server in the first data center then decides where to route the request. For example, a content server may decide to redirect the request to a second data center. This may be because the other data center may be closer to the user, servers for the first data center may be overloaded or down, etc. Thereafter, future requests for the same content are still sent to the first data center, which then redirects the request to the second data center. Thus, the path for the request always goes through the first data center.A slowing down of proton motion from HPTS to water adsorbed on the MCM-41 surface.
We report on the steady-state and femtosecond-nanosecond (fs-ns) behaviour of 8-hydroxypyrene-1,3,6-trisulfonate (pyranine, HPTS) and its interaction with mesoporous silica based materials (MCM-41) in both solid-state and dichloromethane (DCM) suspensions in the absence and presence of water. In the absence of water, HPTS forms aggregates which are characterized by a broad emission spectrum and multiexponential behavior (τsolid-state/DCM = 120 ps, 600 ps, 2.2 ns). Upon interaction with MCM41, the aggregate population is found to be lower, leading to the formation of adsorbed monomers. In the presence of water (1%), HPTS with and without MCM41 materials in DCM suspensions undergoes an excited-state intermolecular proton-transfer (ESPT) reaction in the protonated form (ROH*) producing a deprotonated species (RO(-)*).


will also be closed half the day, and so on — the type of analysis that it commissioned for the RAOI.

“Sufficient” and “adequate” are the refrain. But why is that good enough? Why is it okay for people living in cities and suburbs to have a post office open 8 ½ hours a day, while those living in small towns must accept 2, 4, or 6 hours a day? Doesn’t that double standard discriminate against rural Americans? The advisory opinion doesn’t discuss these questions.

Whatever happened to a maximum degree?

One of the main purposes of an advisory opinion is to render a view about whether or not the change in service proposed by the Postal Service conforms to existing statutes, particularly title 39 — the Postal Reorganization Act, whichof an era

There’s also nothing in the advisory opinion about how POStPlan spells the end of the institution of the small-town postmaster. Of the 17,000 small post offices reviewed for POStPlan, 3,000 currently have postmaster vacancies; over the next two years, some 10,000 more postmaster positions will be eliminated. This means that thousands of small towns across America will no longer enjoy the benefits associated with having a full-time, career postmaster.

While there are obviously many excellent postmaster reliefs serving their communities, it’s inevitable that the quality of service will decline when all those experienced career postmasters are replaced by part-time workers earning about $11 or $12 an hour, with no benefits and virtually no opportunity for advancement. These workers will be supervised by a postmaster in another town,


full services to millions of average Americans?

While $300 million is nothing to shake a stick at, downgrading 13,000 post offices is nothing to brag about, and it will do serious harm to the Postal Service brand. Over the next two years, the Postal Service will hold 13,000 community meetings and a spokesperson will rationalize the cut in hours by emphasizing how close to the precipice the Postal Service is. There will be tens of thousands of news items about those meetings, each of which will quote someone from the Postal Service saying how dire the financial situation is. That sort of talk is just not good for the brand or for business.

Those are the kinds of considerations that a real cost-benefit analysis would have considered. Instead, we getthe Postal Service would also set up a VPO to help make up for the reduced hours.

The Commission notes this “ambiguity” and “inconsistency” several times in the advisory opinion, and one of its main recommendations is that the matter be cleared up. Having questioned the validity of a VPO as a substitute for a post office in its RAOI advisory opinion, the Commission obviously prefers the view expressed by Mr. Day in his testimony. It therefore recommends that the survey and instructional memo “should reflect POStPlan policies,” i.e., that a VPO is an enhancement not a replacement for a post office.

It will be interesting to see if the Postal Service follows this recommendation. It has been talking about using the VPO as a replacement for post offices for


are conjugated to $\mathfrak{P}_{\infty}$.

In particular, the order of $\textup{Aut}(T_m/K)$ is bounded by $$|\textup{Aut}(T_m/K)| \geq
\left\{ \begin{array}{cl}
2q^2(q-1) & \ \text{for}  \ q \ \text{odd}  \ \ \text{ or } \  m=1 \\
q^3(q^2-1) & \ \text{for} \ q \ \text{even}  \ \text{and} \ m = 2 \\
2q^4(q-1) & \ \text{for} \ q \ \text{even}  \ \text{and} \ m\geq 3.
\end{array}\right.$$

Thus we have specified a subgroup of $G_m$ properly containing $G_m(\mathfrak{P}_{\infty})$ which we conjecture to be the entire automorphism group of the norm-trace tower $T_m/K$. For $m=1$ and $q\neq 2$ this is the result of Aleschnikov [@AleGB]. In the final section \[FullAutomorphism\] we present our proof for the sharpness of the bounds of Theorem \[Hauptsatz2\] for $m=2$ and $m=2,3,4$ for even $q$ respectively. In summary we$$Z_m=K(z_0,\ldots,z_m) \qquad \text{with } z_i=x_i^{q-1}.$$ Following assertions hold:

1.  The decomposition field of $\mathfrak{P}_{\infty,m}$ in $T_m/T_m^{G_m}$ is $$T_m^{G_m(\mathfrak{P}_{\infty})} = Z_{m-\varepsilon} \qquad \text{for } m\geq 1.$$

2.  The fixed field of the group $G_m(\mathfrak{P}_{\infty}\prod\mathfrak{P}_a)$ generated by the automorphisms of $T_m/K$ permuting the support of $x_0^{q-1}+1$ is $$Z_{m-\varepsilon-1}^1 = K(z_1,\ldots,z_{m-\varepsilon}) \qquad \textup{for }m\geq 1 + \varepsilon.$$

3.  The defining relations for $z_0,\ldots,z_m$ are $$z_{i+1}(z_{i+1}+1)^{q-1} = \frac{z_i^q}{(z_i+1)^{q-1}}.$$

4.  The decompostion tower $Z_m/K$ satisfies the equalities

    $Z_m=Z_{m-1}(\frac{x_m}{x_{m-1}})=Z_0(\frac{x_1}{x_0},\ldots,\frac{x_m}{x_{m-1}})
    =K(x_0^{q-1},\frac{x_1}{x_0},\ldots,\frac{x_m}{x_{m-1}}).$

    The minimal relation for the extension $Z_{i+1}/Z_i$ is $$\left( \frac{x_{i+1}}{x_i} \right)^q + \frac{1}{z_i} \left(\frac{x_{i+1}}{x_i}\right) = \frac{1}{z_i+1}$$ and the minimal relation for $Z_{i+1}/K(z_1,\ldots,z_{i+1})$ is $$\left(\frac{x_{i+1}}{x_i} \right)^q  + z_{i+1} \left(\frac{x_{i+1}}{x_i} \right) = \frac{z_{i+1}}{z_{i+1}+1}.$$ In particular $T_m=Z_m(x_i)$ holds for $0\leq i \leq m$ and $Z_m/K$ is a


norm-trace tower. This proves our statement.

Now we can establish the number of rational places and the genus of $Z_m/K$.

 \[5theorem1\]

The decomposition tower $Z_m/K$ of height $m\geq 1$ has $$N_1(Z_m/K) = q^{m+1}+q^2-q+2+\varepsilon^*_m$$ rational places with $\varepsilon^*_m=\varepsilon_m/(q-1)$. (See Proposition \[2prop1a\] for the definition of $\varepsilon_m$.)

Proposition \[5prop2\] yields a complete view over the rational places of $Z_m/K$. In the parts (a) and (d) we find $4+\varepsilon^*_m$ rational places. It remains to consider the rational zeros of $z_0-d$ with $d\neq 0,-1$. The zero divisor of $z_0-d$ with $d=b^{q-1}$ for some $b\in K$ is completely decomposed in $Z_m/Z_0$ and has $q^m$ rational prime divisors. For $b\neq b^{q-1}$ there is just one rational place dividing $(z_0-d)_0$. With $s:=\#\{ d\in K : d=b^{q-1}\neq 0,-1 \}$ we get $$N_1(Z_m/K) = s\cdot q^m + (q^2-2-s) + 4 +characteristic and $m=2,3,4$ in even characteristic respectively. We will use the Hurwitz formula for the relative genus [@Sti Theorem III..4.12] of $T_m/T_m^{G_m}$ in order to achieve bounds for the decomposition index $r_{\infty}$. First we consider the ramification of the field extensions $$T_m\geq T_{m-\varepsilon} \geq Z_{m-\varepsilon}=T_m^{G_m(\mathfrak{P}_{\infty})} \geq T_m^{G_m(\mathfrak{P}_{\infty}\prod\mathfrak{P}_a)} =Z_{m-\varepsilon-1}^1.$$

\[6prop0\] The extension $T_m/Z_{m-\varepsilon-1}^1$ is unramified outside $x_0^q+x_0$ for $m\geq 1 + \varepsilon$.

We already know that this assertion is true for the extension $T_m/Z_{m-\varepsilon}$ by Proposition \[2prop1\] and the proof of Theorem \[5theorem1\]. Hence it remains to consider the extension $Z_{m-\varepsilon}/Z_{m-\varepsilon-1}^1$. For abbreviation we substitute $m-\varepsilon \mapsto m$ and define $T_{m-1}^1:=K(x_1,\ldots,x_m)$. This field is isomorphic to $T_{m-1}$ as well as $Z_{m-1}$ is isomorphic to $Z_{m-1}^1$ under the map $x_{i-1}\mapsto x_i$ for $1\leq i\leq m$. By the proof of Theorem \[5theorem1\] the


impossible by Corollary \[6prop2\], while the other cases leads to the verification of our hypothesis.

We queried Magma for the automorphisms of the decomposition tower. It seems that $Z_m/K$ has only two automorphisms namely those generated by the ”reflection” automorphism $z_i\mapsto 1/z_{m-i}$.

**Acknowledgement.** I am deeply grateful to Bernd Heinrich Matzat for his support of my studium and my diploma thesis. Many thanks to Florian Heß for his helpful comments on this article.

I acknowledge the support of the Berlin Mathematical School, which is funded by the German Science Foundation (DFG) as a Graduate School in the framework of the “Excellence Initiative”.

[^1]: Universität Paderborn, lagemann@math.uni-paderborn.de
Chanel has finally told Avi they can`t keep having sex, but Avi thinks Chanel needs to be reminded just what she is giving up, as Avi begins kisses and caressing Chanel`s perfect round breasts and wet, hot pussy. Chanel can`t argue with this very effectiv

20 clicks

Pole Party. Uma, Iwia

83 clicks

She starts playing with herself and hoses the whole bed with more cum. When Mindi confesses that she would like to make her feel that good, Abella gets worried, stating that her dad wouldn`t like it. When Mindi assures her that it`ll be their little secre

70 clicks

LesbianChunkershd

52 clicks

EvilAngel HD

36 clicks

Cum squat. Malena Morgan Lily Love

48 clicks

Attractive blonde gets her pussy licked by sweet brunette.

48 clicks

ClubSapphic - Very Must-See Threesome - Elex...

17 clicks

Sexy talk. Brianna Ray Mahina Zaltana

33 clicks

Girls at


richness (i.e., the number of morphs). In contrast, female morph diversity is not related to sex ratio. These results suggest a relationship between the intensity of male intrasexual competition and male morph diversity. While other selective forces may interact with sexual selection in maintaining the color polymorphisms in P. muralis, this evidence suggests a complex evolutionary scenario possibly involving frequency-dependent selection of alternative reproductive tactics and/or complex balancing selection.of inhibition of cell proliferation was calculated using the following formula: $$\begin{array}{l}
{{Proliferation}\ {inhibition}\ \left( \% \right)} \\
{= \frac{Mean\ No.\ of\ untreated\ cells\ \left( {DMSO\ control} \right) - Mean\ No.\ of\ treated\ cells\  \times 100}{Mean\ No.\ of\ untreated\ cells\ \left( {DMSO\ control} \right)}} \\
\end{array}$$

2.4. Double Staining Assay {#sec2dot4-cells-08-01624}
--------------------------

U87 and LN229 cell lines were grown as described previously, followed by cells treatment with IC~50~ concentration of 5a and incubated for 48 h. Untreated (Negative) and Cisplatin (positive) controls were also maintained. Apoptosis/necrosis detection was carried out using Annexin V-FITC and PI (Thermo Fisher Scientific). The apoptosis determination was performed following the standard protocol suggest by the manufacturer. Briefly, the cells were cultured in 6-well plate with an initial cell density of 7 × 10^5^ cells/well. The cells were incubated


in a humidified incubator supplemented with 5% CO~2.~ A negative control was maintained as well. All conditions were conducted in triplicated samples for the isolation of RNA. Total RNA of \>9.25 ng/µL was isolated using GeneJET RNA purification kit (Catalog no \#K0731), according to the manufacturer's instructions. The yield was then measured spectrophotometrically using NanoDrop-1000 (Thermoscientific, Wilmington, NC, USA). After quantification, the cells were considered for quality assessment by TapeStation. The gene expression analysis was performed by using Illumina Next Seq High throughput profiling (Illumina NextSeq 500). The sequencing produced data in bcl format which was converted into FASTQ file format.

2.8. Transcriptome Analysis {#sec2dot8-cells-08-01624}
---------------------------

Differential expression (DE) and statistical analysis were performed using DESeq2 \[[@B18-cells-08-01624]\] (release 3.3) in R (version 3.2.4) (<https://bioconductor.org/packages/release/bioc/vignettes/DESeq2/inst/doc/DESeq2.html>). *p*-values were adjusted for multiple testing usingU87 **5a**-treated cells displayed an increase of caspase 3/7, displaying a 0.43-fold increase in comparison to untreated cancer cells, whereas positive control displayed no significant increase (0.003) in caspase activity ([Figure 2](#cells-08-01624-f002){ref-type="fig"}b). Similarly, in LN229 cells **5a**-treated cells demonstrated 1.37-fold increase with respect to untreated cells, whereas the standard drug cisplatin exhibited 0.05 fold increase in caspase levels. The difference between treated and untreated conditions was confirmed to be statistically significant per ANOVA test (*p*-value \< 0.05).

3.4. **5a** Enhanced Apoptosis and Cell Cycle Arrest {#sec3dot4-cells-08-01624}
----------------------------------------------------

Defective apoptotic machinery enhances tumor pathogenesis by permitting survival of genetically unstable cells leading to treatment resistance. To understand if the decrease in viability was due to apoptosis, we treated U87 cells with IC~50~ of 5a and we determined the apoptosis effect using double