available methods used in removing heavy metals from various wastewaters have their limitations and are inadequate or too expensive to treat very acidic wastewater of pH less than one and very concentrated heavy metal wastewater at the level of thousands ppm.
The hydroxide precipitation/clarification process adjusts the pH of the wastewater with an alkaline reagent to reduce the solubility of the dissolved metals. Settling occurs and the resultant metal hydroxide precipitates are removed. Sodium hydroxide (NaOH) is most commonly used for hydroxide precipitation. Sulfide precipitation, which precipitates metals as sulfides instead of hydroxides, achieves low levels of metal solubility in highly chelated wastewater streams. Since each metal hydroxide has a characteristic solubility that is dependent on pH, the optimal pH for precipitating all regulated metals to the discharge level   }
})

myApp.filter("displayBool", function(){
  return function(input) {
    if(input) {
      return "Open"
    } else {
      return "Closed"
    }
  }
})

Things to notice, there is a function in scope that is calling into the service: callServiceWith and it is being called from the template. The output is being run through a custom filter called displayBool.


designed specifically for the Parallel (LPT) protocol.  My scoreboard will support RS232, RS422, RS485, or 20mA current loop.  I have done a fair bit of programming for RS232 devices, but my technical knowledge of serial communications if limited.  Any help is much appreciated.

A:

http://pythonic-wisdom.blogspot.com/2008/11/accessing-parallel-port-on-linux-from.html
In short, yes you can, there are limits on achievable baudrate, maximum is via inb/outb, usable through python gpio module, around 300,000 operations a second, that is at 300kbaud if you only write to the port. Using linux /dev/parport is at least twice slower.
If you only need 9600 baud for example, it is quite possible to achieve reliable transmission, although you have to be prepared for your transmission or reception being interrupted by linux scheduling or python gc.
Another issue is voltage levels, youregime payroll," says Abdel, 34.

Abdel sold his RPG to help cover the medical bills of a wounded comrade. "Not only have they (ISIS) pushed [US President Barack] Obama to view Assad as the lesser evil. But when we were taking over Aleppo, last July, when Aleppo was about to fall, they began to blame us for not being true Muslims and turned against us. They didn't liberate an inch of Syria. Look at Raqqa. They have only occupied what we gained."

Rumors of ISIS’ cooperation with the Syrian regime abound. And indeed, they enjoy a strange immunity from regime airstrikes. The only certainty is that all rebels are busy fighting against ISIS. "After all, … how could we really engage the regime? We have no anti-aircraft weapons. We have


But we can prevent Assad from governing and [force] him to compromise. This is the red line: Assad must go."

The model, he says, is Homs, where cease-fires are now beginning to appeal to weary rebel fighters in Aleppo. "We are not surrendering, because we will prevent Assad from staying in power, but through other means. Nobody can prevail with weapons. Do you know what is there, on the western side, in the direction of this mortar? Do you know what I am shooting at? There is my house. I am shooting at my house."= Replace(ws3.Cells(i, 28), ",*", "")
        x = Left(y, InStr(y, ",") - 1)                    `changed space to comma here
        ws3.Cells(i, 28) = x
    End If
Next I

EDIT:
The overflow error can originate from the InStr function as that will always return an integer. This ofcourse depends on the length of the cell text.
However you are basicly doing the same operation twice. Under Y you replace the comma and everything after that by "".
Then under X you are going to look in the result of Y for comma, which isn't there anymore due to your


New York." "You." "Hey, Doc." "You." "I'm gonna see a lot of you." "Where were you?" "My God, I woke up and you were gone!" "here was no note or anything!" "I was out of my mind!" "I walked all over the hotel looking for you." "I even ate a Rice Krispy reat." "I almost called the police." "No, don't call the police." "I'll tell you the truth." "I had a patient emergency." "You have patients in Florida?" "One." "He followed me from New York." "I had to go, trust me." "My God." "Who is this patient?" "Paul Vitti." "Mafia Paul Vitti?" "Oh, my God." "It's not like he's a regular patient." "He's got problems." "He thinks that I'm treating him." "It's crazy." "So you're not treating him?"this guy is, he must be important to the family." "Put his picture on the wire." "See what you come up with." "Normally, a patient wouldn't have a vat of scotch during a session." "hat's interesting." "I'll have to remember it if I'm ever on Jeopardy." "ell me about your father." "My father." "Well, my father..." "Let's sit here." "My father." "A big man in the neighborhood." "Everybody loved him." "Very well-respected, God rest his soul." "He passed away?" "I just like saying "God rest his soul. " Of course he passed away!" "I was about 12 at the time." "How did he die?" "It was a sudden thing." "A heart attack." "How was the relationship?" "Were you close?" "We were pretty close." "We weren't getting along great


is out that you're talking to a shrink." "Is that right?" "What's the point here?" "he point is this concerns the whole family." "Right now, we're the only ones that know about it." "If this ever gets out in the street, we're dead." "Who knows what you're saying to him?" "It ain't nobody's fucking business." "I beg to differ." "If you're looking to establish an insanity plea for later on that's okay." "But everybody'll think you're falling apart." "It's not right." "hey'll think this is a sign of weakness." "Sindone will take over everything." "Is that what you want?" "What do you want me to do?" "It's time to end it, Paul." "What do you mean, end it?" "Get rid of the shrink." "He knows too much." "Youreally have to talk to you." "Who is that?" "ommy Angels." "We grew up together." "Worked for a crew out of Jersey City." "How did he die?" "He was on his way to talk to a federal prosecutor." "Got hit by a truck." "wice." "I don't need to know this." "I can't hear this." "his is too much for me." "I'm having nightmares myself." "he other night, I dreamed we were walking down the street and I stopped to buy fruit." "Out of nowhere, two guys come and they kill me like Marlon Brando in The Godfather." "Good scene." "What'd I do?" "You drop your gun." "You run up to me and you yell, "Papa!" "Papa! "" "I was Fredo?" "I don't think so." "You're starting to lose


them." "Dressed like a busboy." "Your father saw him too?" "I knew the guy looked wrong." "Why, Paul?" "he pants." "Looked too good for a busboy." "So he walked to the table." "I watched him the whole way." "Did you say anything?" "Dad was so mad at me, I couldn't say anything." "And you were mad at him." "And then what happened?" "I never saw the second guy." "My mother just started screaming." "And you blame yourself." "I could've saved him." "But you were mad at him." "I should've said something." "You couldn't have saved him, Paul." "I killed him." "You didn't kill him." "You were mad, but you didn't kill him." "It's the life he chose." "I just let him die." "I let him die!" "I letto say?" "Well, he wants me to call him "big boy" and he's my "bucking bronco" and I'm supposed to "ride him hard" and "put him back in the barn wet. "" "Are you okay, Dr. Sobel?" "Well, it's..." "Here's what I think you should do, Elaine." "I would do whatever he says." "If he wants you to talk, talk." "I'd get down and bark like a dog." "I'd do whatever it takes." "Smoke some joints, drink wine, whatever it is to get off on each other and be happy." "Where are you running?" "his is a time to be happy!" "Because life is just too short." "It's just too fucking short." "I'll see you hursday." "Everything okay?" "Feeling all right?" "You need anything?" "No." "Feel great." "Never


is insane!" "It's all right." "Let's go over it again." "Mr. Vitti's been detained." "Apologies all around." "And then you say you're the new consigliere...  ...speaking for Mr. Vitti." "hen what?" "hen you keep your mouth shut and hope nobody asks you nothing." "hat's some plan you got there." "Shut up!" "Doc, if you gotta talk try to be vague." "Could you do that?" "I'm a psychiatrist." "Believe me, I can be vague." "Looks like they're headed for the tunnel." "We'll pick them up on the other side." "Here they come." "Which one is it?" "The black one." "Are you sure you don't want something to eat?" "You want some iced tea?" "I think I'm gonna call Dr. Erragrossa." "Is Daddy gonna be all right?" "I thinkbelieve this." "You took a bullet for me." "What doc would ever do that for his patient?" "I'll never forget that." "You...!" "I tripped." "You tripped!" "You tripped over your unconscious." "Mr. Vitti, you have the right to remain silent... oday's my wedding day." "You got off easy." "Eighteen months is nothing." "hey found Primo Sindone dead in a field near La Guardia." "I heard." "Don't look at me." "I had nothing to do with it." "A million guys from here to Canarsie were looking to whack that bastard." "Good." "I was just checking." "Don't worry." "You think we could keep going with the private sessions up here?" "You'd like to do that?" "I could arrange to come up on Saturdays." "Or we could do it by phone."


1. Introduction {#sec1}
===============

A wide variety of heterocyclic systems have been explored for developing pharmaceutically important molecules. Heterocycles form by far the largest of the classical divisions of organic chemistry \[[@B1]\]. Generally N-based heterocycles have been the object of considerable focus because N-containing heterocycles are structural components of many bioactive natural products such as vitamins, hormones, antibiotics, alkaloids, glycosides, and many more compounds which are of significance for human and animal health \[[@B2]\]. Many natural drugs such as quinine, papaverine, emetine, theophylline, atropine, codeine, morphine, and reserpine are N-containing heterocycles \[[@B3]\]. Therefore, N-containing heterocycles are especially considered ''privileged" structures for the synthesis and development of new drugs \[[@B4], [@B5]\]. Tetrazoles and their derivatives have been reported as antibacterial \[[@B6]\], antiviral \[[@B7]\], herbicidal \[[@B8]\], anti-inflammatory \[[@B9]\], antitumor \[[@B10]\], analgesic \[[@B11]\],Figures [4](#fig4){ref-type="fig"} and [5](#fig5){ref-type="fig"}, respectively.

The*in vitro* antifungal MIC values are correlated well with binding energies obtained through molecular docking with*dihydrofolate reductase* (PDB**1AI9**) of*C. albicans.*Docked ligand molecule**28** with the secondary protein structure of*dihydrofolate reductase* in solid and ribbon model is depicted in [Figure 6](#fig6){ref-type="fig"}. The minimum fungal inhibition potency*C. albicans* of compounds**25** (25 µg/mL),**26** (6.25 µg/mL), and**28** (12.5 µg/mL) showed excellent docking energies. Its total docking energies are −8.91, − 8.70, − 9.27 kcal/mol, respectively, shown in [Table 5](#tab5){ref-type="table"}. From the comparative analysis, compounds**27** and**28** showed minimum docking energy with targeted protein and the*in vitro* studies also support that compounds**27** and**28** have become active against all the tested microorganisms. The abovementioned compounds utilize their amino head group to interact with the crucial amino acid residues such as Glu 116, Thr 58, Lys 57,


their structures were characterized by their IR, ^1^H NMR, ^13^C NMR, and mass spectral data. The synthesized compounds showed a wide range of potentially promising antibacterial and antifungal activities. Compounds**25**,**26,** and**28**showed significant microbial activity against the tested bacterial and fungal strains. The docking study reveals that hydrophobic interactions played a major role in ligand receptor interactions.

4. Experimental {#sec4}
===============

4.1. Chemistry {#sec4.1}
--------------

All the reactions were routinely monitored by thin layer chromatography (TLC). All the reported melting points were taken in open capillaries and were uncorrected. Infrared (IR) spectra were recorded in KBr (pellet forms) on a Thermo Nicolet-Avatar-330 Fourier Transform Infrared (FT-IR) spectrophotometer and only noteworthy absorption values (cm^−1^) were listed. ^1^H and ^13^C NMR (nuclear magnetic resonance) were recorded with Bruker AMX-400 spectrometer at 400 and 100 MHz, respectively. NMRfor 10 days. After treatment, the content differences of serum apoptosis factors (PDCD5, sFas and sFasL), neurological function indices (BDNF, NSE, S100-β and NGF) and oxidative stress indices (SOD, MDA and GSH-PX) were observed in the two groups. After treatment, the levels of serum PDCD5, sFas, sFasL, MDA, NSE and S100-β in the treatment group were lower than those in the control group (all p<0.001). The contents of serum SOD, GSH-PX, BDNF and NGF in the treatment group were higher than those in the control group (all p<0.001). Monosialoganglioside can effectively improve the apoptotic factors, neurological function and oxidative stress indices in newborns and maintain the stability of the internal environment, so it is worthy of promotion and application.


or rewrite data, and/or to supply power to the tag. In response, the reader will receive a RF signal from the RFID tag containing information. Clear electromagnetic communications between the tag and reader are critical for proper transmission of data. Anything interfering with RF signals in the area can create a problem that must be addressed.
RFID tags can suffer from significant RF signal degradation when placed in proximity to a material. The degree of degradation is related to the electromagnetic properties of the material, the distance between the antenna and the material, and the frequency of the signal. Unfortunately, many materials to which it would be desirable to attach an RFID tag have poor electromagnetic characteristics for the transmission of signals using common RFID operational frequencies. Such commonwith no effective treatment options. This study and the SELECT trial ([@B15]) supported regulatory approval of lenvatinib for unresectable thyroid cancer in Japan, and lenvatinib is now commercially available there for the treatment of ATC ([@B24]).

As lenvatinib demonstrated striking efficacy in RR-DTC ([@B15]), we hypothesized that the ATC subtype may be sensitive to lenvatinib based on evidence that ATC tumors evolved from a background of differentiated thyroid cancer ([@B25]). Preclinical studies have also shown that lenvatinib reduced tumor growth in human ATC xenograft mouse models ([@B19]). The high vascularity of ATC tumors may also make them more responsive to angiogenesis inhibition by lenvatinib ([@B26]).

The ORR in patients with ATC on lenvatinib was noteworthy, with four (24%) patients achieving a partial response, 12 (71%) achieving stable disease, and eight


the risk of developing cardiotoxicity with increasing total cumulative doxorubicin doses in excess of 400 mg/m^2^, prolonged doxorubicin treatment is problematic ([@B30]).

Although there were no bleeding events in the current study, post-marketing surveillance in Japan recently reported some cases of carotid artery and tumor hemorrhage due to rapid tumor shrinkage in patients with ATC treated with lenvatinib. This is further evidence of the antitumor activity of lenvatinib in patients with ATC, although careful administration is especially warranted for patients with tumor invasion of the carotid arteries.

This study has several limitations. First, it is a non-randomized study with a relatively small patient population. Second, there was no biomarker evaluation of tumor samples. Finally, the results for the ATC subgroup represent only one cohort of the study that was not designed[Karyotype analysis on Iris lactea ssp. chinensis].
In this paper, the chromosome number, karyotype and chromosome volume of Iris lactea ssp. chinensis were reported. The normal diploid was 2n = 32. Karyotype formula was based on Levan's publication in 1964, k (2n) = 32 = 22 m + 8 sm + 2T. According to the method of Kuo SR, the species chromosome based on the relative length was 2n = 32 = 6L + 4 M2 + 18 M1 + 4 S which belong to "2A" type according to the Stebbins' karyotype classification. The AS.K% was 62.5% from Arano's method. The total volume of chromosome groups was 34.95 micron 3.


---
author:
- Annika Lang
bibliography:
- 'MCQMC14.bib'
title: A Note on the Importance of Weak Convergence Rates for SPDE Approximations in Multilevel Monte Carlo Schemes
---

Introduction {#sec:Intro}
============

Since the publication of Giles’ articles about multilevel Monte Carlo methods [@G06; @G08], which applied an earlier idea of Heinrich [@H01] to stochastic differential equations, an enormous amount of literature on the application of multilevel Monte Carlo schemes to various applications has been published. For an overview of the state of the art in the area, the reader is referred to the scientific program and the proceedings of MCQMC14 in Leuven.

This note is intended to show the consequences of the availability of different types of convergence results for stochastic partial differential equations of Itô type (SPDEs for short in what follows). Here we consider so called strong and weaklet $(\Omega, \mathcal{A}, (\mathcal{F}_t)_{t\geq 0}, P)$ be a filtered probability space satisfying the “usual conditions” which extends the probability space already introduced in Section \[sec:MLMC\]. The corresponding Bochner spaces are denoted by $L^p(\Omega;H)$, $p \ge 2$, with norms given by $\|\cdot\|_{L^p(\Omega;H)} = \mathbb{E}[\|\cdot\|_H^p]^{1/p}$. In this framework we denote by $W= (W(t), t \ge 0)$ a $(\mathcal{F}_t)_{t\geq 0}$-adapted $Q$-Wiener process. Let us consider the stochastic partial differential equation $$\label{eq:SPDE}
 \D X(t) = (AX(t) + F(X(t))) \, \D t + \D W(t)$$ as Hilbert-space-valued stochastic differential equation on the finite time interval $(0,T]$, $T < + \infty$, with deterministic initial condition $X(0) = X_0$. We pose the following assumptions on the parameters, which ensure the existence of a mild solution and some properties of the solution which are necessary for the derivation


triangle inequality we obtain that $$\begin{aligned}
  \| \mathbb{E}[\varphi(X(t_k^n))] - & E_N[\varphi(X_{\ell,n}(t_k^n)))]\|_{L^2(\Omega;{\mathbb{R}})}\\
    & \leq
      \| \mathbb{E}[\varphi(X(t_k^n))] - \mathbb{E}[\varphi(X_{\ell,n}(t_k^n)))]\|_{L^2(\Omega;{\mathbb{R}})}\\
    & \qquad + \|\mathbb{E}[\varphi(X_{\ell,n}(t_k^n)))]- E_N[\varphi(X_{\ell,n}(t_k^n)))]\|_{L^2(\Omega;{\mathbb{R}})}.
 \end{aligned}$$ The first term is bounded by the weak error in Theorem \[thm:weak-conv\] while the second one is the Monte Carlo error in Lemma \[lem:MCerr\]. Putting these two estimates together yields the claim.

The errors are all converging with the same speed if we couple $\ell$ and $n$ such that $h_\ell^2 \simeq \Delta t^n$ as well as the number of Monte Carlo samples $N_\ell$ for $\ell \in {\mathbb{N}}_0$ by $N_\ell \simeq h_\ell^{-4\gamma}$. This implies for the overall work that $$\mathcal{W}_\ell
    = \mathcal{W}_\ell^H \cdot \mathcal{W}_\ell^T \cdot \mathcal{W}_\ell^{\text{MC}}
    = \operatorname{O}(h_\ell^{-d} (\Delta t^n)^{-1}      $\epsilon_L^{-(d/2 + 3)}$                                 $\epsilon_L^{-(d+2)}|\log_2 \epsilon_L|$                                             $\epsilon_L^{-(d/2 + 2)}|\log_2 \epsilon_L|$

  : Computational work of different Monte Carlo type approximations for a given precision $\epsilon_L$.\[tab:WorkMCvsMLMC\]

Simulation {#sec:Simulations}
==========

In this section simulation results of the theory of Section \[sec:SPDE-MLMC\] are shown, where it has to be admitted that the chosen example


What do you do when your favorite Chrome extension stops working or gets pulled from the Chrome Web Store by its author or Google? While you could hope that the developer posts an update eventually - at least in the first case scenario, you are left with looking for alternatives in the second.

While you could now head over to the Chrome Web Store to frantically search for related terms in hope of finding a suitable alternative, you could also make use of the store's related feature instead. Please note that this only works for extensions still listed in the store. If you see the following or a similar error message in the store, you need to work around the issue first.

Finding Related Chrome Extensions

If that happens, you need }

And here my base page :
public abstract class BasePage : Page
{

  public BaseViewModel ViewModel { get; set; }

}

The pages of my app extends the BasePage and contain a nester (inner) class that extends the BaseViewModel class. Here a sample code :
public sealed partial class MyPage : BasePage
{

  public sealed class MyViewModel : BaseViewModel
  {

      public string Title
      {
        get
        {
          return "Test";
        }
      }

    }

    public MyPage()
    {


procedures. It involves some small incisions so that a tool can be used to rub off and suck out the fat cells. The non-invasive option for fat removal is called CoolSculpting, which involves no surgery or downtime. It uses a method which freezes fat so that the fat cells will die off over time (usually around two months). True to its word, there's no need to put anything inside you for this method of getting rid of fat. However, remember that anytime you want to remove fat, it means influencing what's under your skin.

Anti-aging and Wrinkle Treatments

Getting lines and wrinkles is a fear for a lot of women. If you've decided you want to stay looking youthful, surgery can give you long-lasting results. However, for treatments that willoverexpressed PD-D genes were involved in unfolded or incorrectly folded protein responses. Underexpressed PD and PD-D genes shared a common involvement in hormone signaling.

######

Top 20 differentially expressed genes by disease group

![](NG2015001487TT1)

Comparison of PD with CON revealed changes in immune function and neuropeptide hormone function, including upregulation of chemokine (C-X-C motif) ligand 10 (*CXCL10*) and downregulation of proenkephalin (*PENK*). In the comparison of PD-D with CON, genes involved in the unfolded protein response were significantly upregulated, reflected by increased expression of dnaJ (Hsp40) homolog (*DNAJB1*) and several heat shock protein genes, and an overall downregulation of hormone activity and ion transport, indicated by decreased expression of corticotropin-releasing hormone (*CRH*), *PENK*, somatostatin (*SST*), chemokine (C-C motif) ligand 3, and chemokine (C-C motif) ligand 4.

Predominant pathways shared by both PD


and PD-D included upregulated inflammatory responses, with increased expression of granulocyte colony-stimulating factor (*CSF3*), selectin-E (*SELE*), and additional cytokines. Shared downregulated genes for signaling and cytoskeletal structure included decreased expression of *PENK* and keratin 5 (*KRT5*); Vgf nerve growth factor (*VGF*) was also downregulated across disease states.

Alternative splicing. {#s2-2}
---------------------

SpliceSeq identified significant disease-associated differences in transcript variants. SpliceSeq-predicted events were initially filtered for significance (*p* \< 0.01) and dPSI \> \|0.2\|, where dPSI is the change in exon expression of disease (PD or PD-D) vs CON. Additional filtering parameters considered the occurrence of the splicing event across all transcripts in the group (magnitude) and the number of samples within the group experiencing the event (percent observed) -- both set to \> \|0.8\| (1.0 = 100%). Finally, genes with theregion in exon 1. Considering the aforementioned mouse study, alternatively spliced *ATXN2* might interfere with cellular responses by reducing receptor production or membrane incorporation. However, the specific functional effect of this alternative splicing event is unclear.

*LRRFIP1* is a promoter-binding transcriptional repressor that regulates *EGFR* and may also regulate the proinflammatory cytokine *TNF*.^[@R35]^ These functions suggest that it is tied to cell damage and injury response. Exon 18 and 19 (protein position 398--459) skipping was increased in our PD group. Together, they partially encode coiled-coil domains and a prefoldin superfamily domain, protein features that promote protein-protein interactions and molecular chaperoning, respectively.^[@R36],[@R37]^ Exon skipping in this region has the potential to decrease binding affinity with LRRFIP1 targets and to interrupt any chaperone activity this protein may provide.

Although alternative splicing is


a normal mechanism of gene regulation, the pathways in which it is relatively increased suggest altered responses in the disease state. A number of scenarios are possible. An aberrantly spliced transcript may drive a pathway to become overactive, contributing to disease onset or progression. Another possibility is that cells in distress during the progression of PD and PD-D may experience altered splicing as a consequence of widespread dysfunction. Distinguishing between these possibilities is an important goal of future work.

Supplementary Material
======================

###### Data Supplement

Supplemental data at [Neurology.org/ng](10.1212/NXG.0000000000000075)

The authors thank the Banner Sun Health Research Institute Brain and Body Donation Program of Sun City, Arizona, for the provision of human biological materials.

AUTHOR CONTRIBUTIONS
====================

Adrienne Henderson-Smith contributed to laboratory work, experimental design, interpretation of data, and manuscript drafting and revision. Jason J. CorneveauxQ:

Getting last day of previous quarter

When I run
SELECT
  MAKEDATE(YEAR(CURDATE()), 1) + INTERVAL QUARTER(CURDATE())-1 QUARTER - INTERVAL 1 DAY

here, it works as intended. However, in Hive I get an error that I'm missing a closing parenthesis. My query is:
SELECT t1.*, t2.programme
    FROM table1 t1
    LEFT JOIN (SELECT programme FROM table2
        WHERE yyyy_mm_dd = MAKEDATE(YEAR(CURDATE()), 1) + INTERVAL QUARTER(CURDATE())-1 QUARTER - INTERVAL 1 DAY
    ) t2 ON t2.id = t1.id AND t2.yyyy_mm_dd = t1.yyyy_mm_dd

What have I done wrong?

Error while compiling statement: FAILED: ParseException line 4:75 missing ) at 'QUARTER' near 'QUARTER' l

We are using Hive v1.1.0.

A:

This is possible to do in a number of ways. Two methods:
select last_day(printf('%04d-%02d-%02d',year(current_date),(month(current_date)-1) div 3 * 3


$ \hat{\rho}_A=\mathrm{tr}_B[\hat{\rho}] $ is the reduced density matrix of $ A $. In Ref.[@Fan2017], we showed that this Rényi entropy is related to the summation of modified OTOCs at temperature $T/2$: $$\begin{aligned}
\exp(-S_A^{(2)})=&\sum_{W\in B}\mathrm{tr}\left[\hat{W}^\dagger(t)\hat{O}e^{-\beta \hat{H}}\hat{O}^\dagger \hat{W}(t)\hat{O}e^{-\beta \hat{H}}\hat{O}^\dagger \right] \notag \\
=&\sum_{W\in B}\mathrm{tr}\left[e^{-2\beta H}\hat{W}^\dagger(t-2i\beta)\hat{O}(-2i\beta)\right. \notag\\
&\quad\left.\hat{O}^\dagger(-i\beta)\hat{W}(t-i\beta)\hat{O}(-i\beta)\hat{O}^\dagger(0) \right], \label{OTOC_EE}\end{aligned}$$ The summation over $\hat{W}$ is taken over the complete set of operators in system $B$, and $ \hat{V} $ is fixed to be $ \hat{O}\hat{O}^\dagger $.

Using this theorem, the dynamics of $S_A^{(2)}$ after a quench is related to the behavior of OTOC under the following two conditions, which are assumed to be true: (i) For long time $t\gg \beta$ each term in the R.H.S. of Eq.  approaches the OTOC $\mathrm{tr}\left[e^{-2\beta \hat{H}}\hat{W}^\dagger(t)\hat{O}\hat{O}^\dagger \hat{W}(t)\hat{O}\hat{O}^\dagger \right]$ [@Maldacena2016; @Yao2016]; (ii) Different terms in the summation of theR.H.S. of Eq.  have similar behaviors. In the rest of this section we will show that during certain time interval after a local quench, $S_A^{(2)}$ will increase linearly with time $t$, which further indicates an exponential deviation of OTOC because of Eq. .

![The growth of the second Rényi entropy $S_A^{(2)}$ and the normalized OTOC $ |\tilde{F}(t)| $ as functions of time $tJ$ for $U/J=10$ at $\beta J=0.9$ and $N=L=6$ with a periodic boundary condition. The linear growth regime of $S_A^{(2)}$ is indicated by a fitted dashed black line. See the main text for more details on the operator choice. []{data-label="entropy"}](EE){width="0.7\columnwidth"}

To study the entropy growth after a local quench for the one-dimensional BHM, we first numerically calculate the second Rényi entropy for a 6-site chain using exact diagonalization method. Here


we consider a quench that removes a boson at the third site, which corresponds to a quench operator $\hat{b}_3$. Then we divide the system into two equal halves in order to calculate the second Rényi entropy. The result is shown in Fig. \[entropy\], where $S_A^{(2)}$ clearly exhibits a linear growth within a time interval. For comparison, we also plot an OTOC with a similar setup by taking $\hat W=\hat b_3$ and $\hat V=\hat b_4$. Clearly, it is during the same time interval that the OTOC starts to deviate from unity. In this sense, the linear growth of the second Rényi entropy implies an exponential behavior of the OTOC.

In fact, specifically for critical one-dimensional model, it is possible to obtain the linear growth of the entropy after a local quench6), and then becomes slower as $U/J$ further increases (from 6 to 8). By fitting the Lyapunov exponents using the scheme introduced above, we find that $\lambda_\mathrm{L}$ displays a broad peak around $U/J=6$, and the peak value is very close to the $ 2\pi/\beta $ bound (Fig. \[OTOCbi\](b)). It is instructive to consider the system at high temperature that is away from the quantum critical region. For temperature as high as $\beta J=0.2$, not only the peak of the Lyapunov exponent disappears, but the magnitude of these exponents are considerably smaller compared with the bound.

To further confirm that the peak indeed comes from the quantum criticality, we calculate the OTOC in the system that is away from the integer filling and hence the quantum critical region. As shown in


Fig. \[OTOCbi\](c), there is no peak in $\lambda_\mathrm{L}$ as $U/J$ increases. Also, the Lyapunov exponents are generally smaller compared to those of the systems at integer filling under the same temperature.

Before proceeding, we would like to make several remarks on the finite-size effect. At even lower temperatures, we find that $\lambda_\mathrm{L}$ could exceed the $ 2\pi/\beta $ bound. We attribute this behavior to two reasons. First, the low temperature is only well-defined when the temperature is still higher than the finite-size gap. While in the BHM of size $ L=7 $, the finite-size gap is comparable to $ \beta J \sim 1 $. So $ \beta J=0.9 $ is almost the lowest temperature we could reach in order to obtain reliable results. Second, the proof of the bound on$t_0$, previously defined as the time for the onset of the deviation, increases linearly with the distance between $i$ and $j$, as shown in the Fig. \[Bv\](a) and the inset of Fig. \[Bv\](b). From this slope we can extract the butterfly velocity and the results are shown in Fig. \[Bv\](b). We find that the butterfly velocity first increases with $U/J$. At large $U/J$ it seems to saturate and even begin to decrease weakly.

It is interesting to compare the butterfly velocity with the Lieb-Robinson velocity [@Lieb1972; @Hastings2006; @Nachtergaele2006], which has been studied both numerically [@Laeuchli2008] and experimentally [@Cheneau2011] for the BHM. Since the Lieb-Robinson velocity can roughly be regarded as the butterfly velocity at infinity temperature, intuitively they should share the same trend but the butterfly velocity is smaller. This is indeed


Using non-invasive ventilation on acute wards: how to provide an effective service.
Non-invasive ventilation is increasingly used on acute wards to treat patients with acute type 2 hypercapnic respiratory failure. This article highlights the main factors that should be considered in providing an acute NIV service outside of a critical care setting.built to last and looks great to boot. It feels solid as and because of this, I have kept it aside since drowning the CZ70 to re-purpose and the EQ and the CZ70 rod seems to be a perfect pairing for me at least.

Definitely looks good. I too am a fan of s-rods and modified my original Sovereign with a CZ70 rod (difference like night & day). I was thinking about doing the same thing with my Equinox, you beat me to it hand

Looking to hear what you think the swing/balance is like. I think the CZ70 rod is a little heavier (haven't weighed it) than the Equinox rod: but I would think, well worth the mod for the sturdiness, stability & portability.

In their respective default setups, the


Related Tags:

MINNEAPOLIS (WCCO) – It’s always been Jamie and Heather Thompson’s dream to have a big family. So when their son, Griffin, was born, they thought it was just the beginning.

But as Griffin is about to turn 5, he remains the Thompson’s only child. The couple has had four miscarriages, the last happened after Heather was pregnant for 14 weeks.

“We had just announced it to everyone, including our son,” Heather said. “It was a very, very difficult time in our life. We definitely learned we have a lot of support.”

It’s the support that kept them going and that support might turn them in a new direction. After much thought, prayer, and research, the Thompsons began looking into what is known as an “open adoption.” That’s where the birthorder of magnitude higher than the SMG and the lower limit for the QSO. Similarly, we find that for the QSO (SMG), the density of ionizing photons is $\ga$900 cm$^{-3}$ ($\sim$200 cm$^{-3}$), assuming all the ionizing photons have an energy of 13.6 eV. Using the results from @odell17, the ionizing photon density in the OrionBar is $\sim$60 cm$^{-3}$. In the QSO, the AGN is about a factor of four more luminous in its ionizing radiation than that due to its star formation, and likely has a much harder radiation field. The globally large ionizing photon intensity and the likely high G$_0$ in the QSO implies that there is sufficient photon intensity in the diffuse molecular gas to maintain a high electron density. This agreement may be fortuitous given


dissipation
-----------------------------------------------

We find that the QSO and SMG lie above a relation between the [L$_\mathrm{H_{2}O\,(2_{20}-2_{11})}$]{}/[L$_\mathrm{IR}$]{} and [L$_\mathrm{IR}$]{} with a slope of 0.19$\pm$0.02 [Fig. \[fig:normLIRLH2O\]; see @yang13 and also @lui17]. @yang13 found a best fitting slope for the relationship between [L$_\mathrm{H_{2}O\,(2_{20}-2_{11})}$]{} and [L$_\mathrm{IR}$]{} that is consistent with what we find, which is not surprising given we are using the same data and only including two additional points. The high [L$_\mathrm{H_{2}O\,(2_{20}-2_{11})}$]{}/[L$_\mathrm{IR}$]{} of both the QSO and SMG of [BR1202-0725]{} indicate that they are among the most, if not the most, luminous emitters of [H$_{2}$O(2$_{20}$-2$_{11})$]{}currently known. The relationship between [L$_\mathrm{H_{2}O\,(2_{20}-2_{11})}$]{} and [L$_\mathrm{IR}$]{} is consistent with IR pumping of the water lines [@G-A14; @yang13; @yang16]. The water abundance is estimated to be an order of magnitude higher for galaxies that lie along the relationship between [L$_\mathrm{IR}$]{} and water luminosity [$\sim$10$^{-6}$; @G-A10] than thepower to modify it, portraying herself in the guise of the Madonna and as Sainte Orlan, creating costumes by using the sheets from her own trousseau and, ultimately, by recourse to surgery. Kahlo’s biographers have been puzzled by her frequent operations, and have questioned whether they were really necessary. Orlan’s surgical performances began in 1979 when she was diagnosed as having an ectopic pregnancy necessitating an emergency procedure. By the time the artist was in the operating theatre she had arranged for a video camera to record the event, and for the tapes to be ferried as fast as they were recorded to the arts centre in Lyon, where they were immediately screened in an extraordinary updating of Kahlo’s Henry Ford Hospital of 1932. Kahlo painted herself in


of whom were obliged to earn their living producing portraits of richer people, flattered themselves in a very different way, because they needed to persuade their patrons that they could make them look glamorous and yet recognisable as them-selves. Vigée Le Brun prefigures Kahlo in that she performed the role in which she depicted herself in real life as well as on canvas. Anxious to bring her corsetted and coiffed clientele into the rosy glow of neoclassicism, she removed her own corset and donned the robe en gaulle, the high-waisted white muslin dress that was to become the uniform of the neoclassical female on both sides of the Channel. She wore her own brown hair unpowdered and uncurled, winding scarves about her head instead of decking it withjewels and feathers. The great difference between the two is that the French artist was inventing a style for a generation, whereas Kahlo’s style is reserved unto herself. Vigée Le Brun also falsified aspects of her representation; in her numerous self-portraits she always showed her mouth as tiny, her teeth no bigger than seed pearls. More importantly, the flesh tones are infinitely seductive, a sign that she could do as much for her sallowest patron.

Frida Kahlo was uninterested in portraying anyone but herself. Her portraits of other people are perfunctory. The Gelmans were important collectors of both her and Rivera’s work. When it was Rivera’s turn to paint Mrs Gelman, he permitted himself an almost laughable degree of flattery, draping her impossibly elongated figure in a clinging white


---
title: 7 funções essenciais do PHP que você deve conhecer
authors: Adriano dos Santos Júnior
type: post
date: 2015-07-03
excerpt: Arranjos, datas, laços e outras práticas para facilitar a programação.
url: /7-funcoes-essenciais-php-que-voce-deve-conhecer/
categories:
  - back-end
  - php
tags:
  - php
  - Código
  - O Básico
---
## range()

Geralmente ao se fazer um “_loop_“, utiliza-se o _while _ou _for_. Ambas estruturas são ligeiramente “_feias_” ao visualizar o código. Uma boa alternativa é utilizar o _foreach_. Mas como fazer uma repetição, se o _foreach_ trabalha com um _array_ existente?

No exemplo vamos fazer um _loop_ de 5 posições, começando do número 1.

<?php
foreach (range(1,5) as $ordem)
{
     print('Ordem : '.$ordem.'
');
}
//Resultado
//Ordem: 1
//Ordem: 2
//Ordem: 3
//Ordem: 4
//Ordem: 5

## array_unique()

Diversas vezes nos deparamos com um _array_ e valores duplicados. Em uma experiência pessoal, trabalhei na criação de um sistema composto por   margin: auto;
}
.note-header-icon .note-icon-annotation .icon {
    width: 15px;
    height: 15px;
}

/* adjustment to center QA icons */
.qa-header-icon .preset-icon-28 {
    top: auto;
    left: auto;
}
.qa-header-icon {
    display: flex;
    align-items: center;
    justify-content: center;
}

/* Keep Right Issues
------------------------------------------------------- */
.keepRight.itemType-20,     /* multiple nodes on same spot */
.keepRight.itemType-40,     /* impossible oneways */
.keepRight.itemType-210,    /* self intersecting ways */
.keepRight.itemType-270,    /* unusual motorway connection */
.keepRight.itemType-310,    /* roundabout issues */
.keepRight.itemType-320,    /* improper _link */
.keepRight.itemType-350 {   /* improper bridge tag */
    color: #ff9;
}

.keepRight.itemType-50 {    /* almost junctions */


railway layer conflict */
.keepRight.itemType-230 {   /* layer conflict */
    color: #b60;
}

.keepRight.itemType-280 {   /* boundary issues */
    color: #5f47a0;
}

.keepRight.itemType-180,    /* relation without type */
.keepRight.itemType-290 {   /* turn restriction issues */
    color: #ace;
}

.keepRight.itemType-300,    /* missing maxspeed */
.keepRight.itemType-390 {   /* missing tracktype */
    color: #090;
}

.keepRight.itemType-360,    /* language unknown */
.keepRight.itemType-370,    /* doubled places */
.keepRight.itemType-410 {   /* website issues */
    color: #f9b;
}

.keepRight.itemType-120,    /* way without nodes */
.keepRight.itemType-400 {   /* geometry / turn angles */
    color: #c35;
}

/* ImproveOSM Issues
------------------------------------------------------- */

.improveOSM.itemType-ow {   /* missing one way */
 big influence on your decision. This article will compare Uber vs. Lyft in seven major categories, so you can decide for yourself which rideshare app is for you.

Jump To:

The next sections will compare and contrast Uber and Lyft in detail. This is aimed to help vest you with all the important information you need to pick the rideshare app that exactly suits your transportation needs.

1. Uber vs. Lyft Services

When taking a look at the battle between Uber and Lyft, one of the biggest factors that set the two services apart is the vehicle options available to passengers.

In many cities across the U.S. and Canada, Uber and Lyft services may seem practically identical. For example, these are direct equivalents that can commonly be found:

Uber caters to businesspeople and professionals


as possible. This manifests itself in a variety of features and policies that each platform has.

To start with, all Uber drivers and Lyft drivers must undergo a variety of driver screening processes. The first part of this is a criminal history background check , which ensures that drivers don’t have convictions for felonies, sexual offenses, or violent crimes. Potential drivers also have to pass a driving history check , have a valid driver’s license, and possess valid liability insurance .

Vehicles must also meet year requirements set by each state and be inspected every year. And only newer vehicles are allowed on the platforms in general, so you know you won’t be riding in a car that doesn’t have airbags or other standard, modern safety features.

On both apps, you’llhome-brew that, coming right out of his East Rock home, has community at its core, Doherty-Nicholson relies on apple tree owners in New Haven and Branford for his fruit. The two communities become his orchard through September, October and November. The arrangement benefits the owners, who do not like to see their extra fruit rot on the ground, as much as it benefits him.

“When I was out in Portland [Oregon], I started this organization — it’s a group, basically — called Community Supported Brewing,” he said on WNHH radio’s “Kitchen Sync.” “Every Thursday we had a party and made 15 gallons of beer … it was a really fun time.”

That was the catalyst for a partner operation in cider brewing, which followed Doherty-Nicholson’s discovery that “95 percent of


the contrary, doctors often caution against alcohol use for its interaction with anti-epileptic medication), there is a proposed one between what are called complimentary therapies — in this case, a sort of normalized social play, à la hard cider — and recovery time. Doherty-Nicholson isn’t interested in writing off his prescribed course of treatment, or proposing that the specific process of brewing is nursing him back to health — but he does think there’s definitely something to it. In sifting through which apples go through the press, he challenges himself to think critically in new ways. When he’s talking to tree owners, he feels like he’s relearning the parts of speech that he lost. Biking around the city is a sort of physical therapy. And the brewing processimportant personal protective measure in the prevention of OCD. Prevention services, occupational health and safety specialists, occupational physicians and centers specialized in occupational dermatology can support the identification of suitable protective measures. Nowadays, suitable protective gloves exist for (almost) every occupational activity and exposure. However, improper use in practice can become a risk factor by itself for the skin (e. g., incorrectly used gloves). Therefore, it is of utmost importance to identify application errors, to educate patients in terms of skin protection and to motivate them to perform an appropriate skin protection behavior. With particular focus on protective gloves, this article gives an overview of various types, materials and potentially glove-related allergens, presents strategies for reducing occlusion effects and discusses some typical application errors and solutions.


with four options and eventually whittled down the options.

He says the one they are going with fits perfectly.

“We wanted to see her and spend time with her and see if we could feel that personality, and she looks exactly like what we’re going to name her,” Brees said.

While Brees always has some advice or insight to share when asked about football, the father of four said he is still at a loss when someone asks for parenting advice.

“I think regardless you’re in way over your head,” Brees said. “As prepared as you think you might be you can read all the books that you want you can ask all the advice you want but until you see it for yourself and it happens for yourself, there’s nothing like18:205, 1972. To be receiving oral anticoagulant warfarin (coumadin). 236 procedure 282 sop 14 patient recruitment strategy* pre- patient information sheet, if they do take a photocopy of the system: The second signal is stored in a postmenopausal woman that occurs when the chemical structures of the. On the other type of drop is formed from formation of a claim, and provide an liver chemistry tests can be transferred throughout the 18.5.1 preparation of a. In case of sneris. Untoward effects of radiation arc not very is the evaluation of trials demonstrated that understand the advantages and disadvantages of the parent hydroxyl compound. Louis, mo, facts and comparisons. Temperature. Soc. Scopolamine hy- ter. Accessed 19 march 2016 301. Anonymous.

Xamster

This approach is to counteract type i tage over the


Q:

How to name Codeigniter controller in Non-ASCII chars to gain SEO friendly URL?

As standard in Codeigniter
A Controller is simply a class file that is named in a way that can be associated with a URI.
And the Controller Class Name = File name but the first char is Capitalized
For example
The URL
example.com/index.php/blog/

The controller
<?php
class Blog extends CI_Controller {

    public function index()
    {
        echo 'Hello World!';
    }
}
?>

My need
In my application we require the URL seems like that
example.com/index.php/Non-ASCII-chars-String/

So How we gain that?

A:

I think that if you want to fix this thing. You need to understand how CI work and especially router in CI.
I think this is the thingvoid setNext(boolean next) {
        this.next = next;
    }

    public List<ComicCard> getResult() {
        return result;
    }

    public void setResult(List<ComicCard> result) {
        this.result = result;
    }

    public void setComic_id(String comic_id) {
        this.comic_id = comic_id;
    }

    public String getComic_id() {

        return comic_id;
    }
}


was head of the firm of L. Richardson & Co, of Port Elizabeth, London, New York and Boston.

The Richardson Baronetcy, of Weybridge in the County of Surrey, was created in the Baronetage of the United Kingdom on 26 July 1929 for the sports shooter and Conservative politician Philip Richardson. The title became extinct on the death of the third Baronet in 1981.

The Richardson Baronetcy, of Eccleshall in the County of York, was created in the Baronetage of the United Kingdom on 20 November 1963 for the prominent physician John Samuel Richardson. In 1979 he was created a life peer as Baron Richardson, of Lee in the County of Devon, in the Peerage of the United Kingdom. Both titles became extinct on his death in 2004.

Richardson baronets, of Pencaithlandreaction, non-enzymatic glycation of proteins, lipids or nucleic acids occur. This alteration in the protein results in change in the enzyme activity \[[@R40]\], decreases ligand binding, extracellular matrix proteins cross-linking causing stiffening and immunogenicity \[[@R41]\]. Moreover, protein glycation has been associated with several diseases as cardiovascular diseases \[[@R42]\], nephropathy \[[@R43]\], neuropathy and cancer \[[@R44]\].

AGE formation can result in malignant transformation due to increased free radical activity causing damage to the cell membranes and gene mutations \[[@R45]\]. AGEs exert their effects by binding to the receptor for advanced glycation endproducts (RAGE). RAGE is over expressed on vascular cells \[[@R46]\], activated immune cells \[[@R47]\] and cancer cells \[[@R48]\]. Moreover, its expression is induced under pathological conditions, by external stress, hypoxia, ROS \[[@R49]\], pro-inflammatory mediators, high glucose, and by AGE itself


stages of breast cancer (stage I & stage II) and highly aggressive, more invasive group which included 100 females (mean age 55.85±6.24 years) with advanced breast cancer (stage III & stage IV). Breast cancer patients were divided based on their TNM classification.

Breast cancer patients were classified according to their immunohistochemistry surrogates into the following subtypes: luminal A (ER+, PR+ and Her2−), luminal B (ER+, PR−/PR and Her2−), Triple Negative Breast Cancer (TNBC) (ER−, PR− and Her2−) and Her2+ (ER−, PR− and Her2+). We excluded all patients with any other diagnosed cancer, chronic renal failure, diabetes mellitus and any disease other than breast cancer from the study, as they may affect the study parameters. Patients taking antioxidant drugs treatment were also excluded. None of the patients received anti-neoplastic therapybefore the study. Demographic and clinical characteristics of all participants were collected and presented in Table [1](#T1){ref-type="table"}. A written informed consent was obtained from all participants.

Samples collection {#s4_2}
------------------

Blood samples were collected after overnight fasting. For genetic analysis, blood was collected in heparinized tubes and stored at -20°C till use. For biochemical assay, blood was collected in tubes without anticoagulant. The samples were centrifuged at 3500 rpm for 10 minutes. Serum was stored at -80°C for GLO1 enzyme activity assay.

Genotyping for GLO1 C332C polymorphisms {#s4_3}
---------------------------------------

Genomic DNA was isolated from the blood using the High Pure PCR Template Preparation Kit (Roche Diagnostics, GmbH, Mannheim, Germany) according to manufacturer\'s protocol. GLO1 C332C genotyping was performed using PCR-restriction fragment length polymorphism (PCR-RFLP) as previously described by Groener et al \[[@R13]\] with some


for 10 min. PCR products for GLO1 were digested overnight at 37°C, using Bsa I restriction enzyme (New England Biolabs Inc., Beverly, MA). The amplified products were separated by 2% agarose gel electrophoresis stained with ethidium bromide and visualized in UV light. Samples yielding 414 bp fragment indicate the presence of wild type (C332C) while 227 and 187 bp long fragments indicate the presence of mutant (A332A). The presence of 414, 227 and 187 bp long occurs in case of (C332A).).

Glyoxalase 1 expression analysis {#s4_4}
--------------------------------

### RNA isolation and cDNA Synthesis {#s4_4_1}

Total RNA was isolated from the blood using Total RNA Purification Kit (Thermo Fisher Scientific) according to the manufacturer\'s instructions. RNA was reverse-transcribed using High-Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific) according to the manufacturer\'s guidelines.

### Real= -4*b - 4*y, 54086 = 5*b - 2*y - 311527. Is b a prime number?
True
Suppose -6*k + 10 = -2. Suppose -5*t - r = -1322 - 4490, -k*t + 2314 = 4*r. Is t prime?
True
Let h be (-1 - -5872) + 5 + -1. Suppose 0 = -a - 4*t + 2939, -2*a - t - 4*t + h = 0. Is a a prime number?
False
Is (1/2)/(4/7112) prime?
False
Suppose 20*z - 19*z - 2 = 0. Let q(k) = 93*k**2 + 3*k - 7. Is q(z) a prime number?
False
Let c be ((-114)/7)/((-2)/14). Suppose 7*k - 5*k = c. Is k prime?
False
Let o(x) = 78*x**3 + 5*x**2 + 2*x + 1. Let q be o(-2). Let r = q + 1834. Suppose 4*b - 2609 - r =


</Storyboard>
                    </Grid.Resources>

                    <VisualStateManager.VisualStateGroups>
                        <VisualStateGroup x:Name="FlashStates">
                            <VisualState x:Name="Flashing" Storyboard="{DynamicResource ResourceKey=FlashingStoryboard}"/>
                            <VisualState x:Name="Stopped"/>
       </Rectangle>

                </Grid>
            </ControlTemplate>
        </Setter.Value>
    </Setter>
</Style>

Here's the code-behind for the control:
public partial class Flasher : Control {

    public static readonly DependencyProperty FillProperty =
        DependencyProperty.Register( "Fill", typeof( Brush ), typeof( Flasher),
                                     new FrameworkPropertyMetadata ( new SolidColorBrush( Colors.Silver), FrameworkPropertyMetadataOptions.AffectsRender ) );


what tomorrow brings.

WEEK THREE: It's been quite a lively day today, the day of the Queen's Speech. For me it was a very, very extraordinary day, all from the way in which the Queen arrived to the House of Lords this morning, the pageantry, the cavalry, the horses. It was absolutely fantastic.

I'm not a great Royalist but to see this display was quite fascinating and I must say really, really enjoyable.

SARAH WOLLASTON - Conservative MP for Totnes

Before becoming an MP, Sarah Wollaston worked for many years as a GP.

She won the UK's first open primary election, with all the voters in the constituency entitled to vote for a Conservative candidate. She courted controversy when she told the Guardian that she spent a lot of time with girls whothese are shown along the left side and the top, **B)** Correlation heatmap of 93 module eigengenes and 12 gluco-metabolic traits, **C)** A Circos plot showing module names (Ring 1), module color representation (Ring 2), correlations between module eigengenes and insulin sensitivity (S~I~) (Ring 3), with the bar height representing absolute value of correlation coefficient (range = \[0.0012,0.53\]) and the bar color for the correlation sign (red -- positive and green -- negative), module specificity to CA (high bar -- CA-specific and low bar -- not CA-specific) (Ring 4), significance of the enrichment for up-regulated genes in AAs with the bar height representing --log10(FET p value) (Ring 5) (range = \[2.2e-39,1\]), significance of the enrichment for down-regulated genes in AAs with the bar height representing --log10(FET p value) (Ring 6) (range = \[5.8e-6,1\]), and


significance of the best enrichment for the modules in AA with the bar height representing --log10(FET p value) (Ring 7) (range = \[0, 0.015\]). The module names and color representations match those in Figure 3A. The modules are sorted based on the correlations between the module eigengenes and S~I~.

Correlation analysis of module eigengenes (principal components of the module) with gluco- and cardio-metabolic traits of CA subjects identified some strong module-trait correlations. As shown in Figure [3](#Fig3){ref-type="fig"}B, some modules were correlated with multiple phenotypes (also see Additional file [1](#MOESM1){ref-type="media"}: Table S5). The clustering of S~I~ and triglyceride (TG) indicates a significant overlap of modules correlated with these two traits in CA subjects. Modules showing significant positive correlation with S~I~ showed significant negative correlation with TG in CA subjects. Module eigengene of 27 modulessubjectsAA Module (Module Size)S** ~**I**~ **correlation(p; FDR)FET p-value (Most Conserved w/ CA Module)Enrichment for S** ~**I**~ **correlated genes (FET_P value)GO Gene.Category (Module Overlap; FET_P)All.corNegAll.corPosCA.corNegCA.corPosAA.corNegAA.corPos**Black (441)0.609 (7.46E-04; 8.07E-07)2.25E-36 (tan)0.182.28E-1011.001.25E-060.867.31E-14organic acid metabolism (46; 1.20E-17)Blue (1392)0.359 (5.61E-02; 9.69E-03)0 (blue)0.566.30E-091.000.171.96E-038.27E-13organelle membrane (93; 1.40E-13)Burlywood (54)0.502 (1.25E-02; 9.04E-05)8.94E-19 (cyan)0.721.73E-090.933.04E-020.951.28E-03Ribosome (3; 3.00E-05)Chocolate (133)0.291 (5.73E-02; 4.75E-02)6.96E-45 (khaki)1.001.52E-041.005.72E-091.000.82acetyl-CoA metabolism (10; 3.50E-16)Gold (147)0.41 (1.75E-02; 2.26E-03)1.96E-11 (green)1.001.70E-041.001.71E-020.962.29E-06Cadherin-mediated cell adhesion (4; 6.60E-04)Gray7 (26)0.357 (6.88E-02; 1.02E-02)4.32E-11 (hotpink)1.008.61E-090.888.20E-040.760.80DNA-dependent ATPase activity (2; 1.40E-04)Green (618)−0.562 (9.18E-04; 7.31E-06)4.64E-25 (seashell)6.30E-141.68E-121.001.006.09E-517.30E-29protein refolding (6; 3.20E-05)Honeydew (69)−0.43 (1.23E-02; 1.20E-03)3.05E-06 (green)7.98E-081.47E-024.19E-020.110.310.40mitochondrion (9; 3.60E-05)Lightcyan (183)0.397 (4.21E-03; 3.35E-03)9.87E-76 (pink)0.758.41E-290.867.09E-291.000.93mitochondrion (35; 2.00E-21)Lightgreen (164)−0.43 (1.06E-02; 1.20E-03)5.34E-67 (yellow)4.15E-151.004.70E-191.000.171.00actin cytoskeleton organization and biogenesis(11; 4.60E-05)midnightblue (186)−0.578 (4.05E-04; 3.53E-06)5.74E-13 (hotpink)3.36E-212.75E-031.000.976.66E-231.94E-05nucleolus (11; 3.70E-07)Red (464)0.578 (4.51E-03; 3.53E-06)2.92E-60 (peru)2.37E-362.83E-060.750.991.12E-031.76E-08Ribosome (24; 1.20E-26)Seashell (124)0.601(3.88E-03; 1.19E-06)6.18E-52 (tan)0.132.41E-531.006.97E-061.001.73E-02alcohol metabolism (10; 1.70E-06)Thistle (92)−0.517(1.54E-02; 4.97E-05)3.05E-07 (yellow)8.67E-050.261.22E-020.640.060.81antioxidant activity (3; 1.40E-03)Turquoise (1980)−0.315(4.74E-01; 2.84E-02)5.01E-169 (yellow)4.94E-231.005.89E-471.001.001.00immune cell activation (82; 9.10E-18)All.corNeg/.corPos, Enrichment


(2; 2.90E-04)Plum(113)−0.384(2.76E-02; 4.88E-035.67E-130.906.43E-030.950.835.02E-070.14small GTPase mediated signal transduction (10; 1.40E-05)Sienna(147)0.299(1.37E-01; 4.02E-02)1.61E-061.001.001.000.960.901.98E-04P-P-bond-hydrolysis-driven transporter activity (6; 5.60E-05)All.corNeg/.corPos, Enrichment for genes that are negatively/positively correlated with S~I~ in both AA and CA subjects; CA.corNeg/.corPos; Enrichment for CA-specific genes that are negatively/positively correlated with S~I~; AA.corNeg/.corPos; Enrichment for AA-specific genes that are negatively/positively correlated with S~I~; FDR, False discovery rate; FET, Fisher's exact test.

Among these ethnicity-specific S~I~-associated modules, "bisque" is most significantly enriched for transcripts negatively correlated with S~I~ in CAs (p =1.85E-16). This module, which has a strong differential connectivity (MDC = 11.16), is enriched for the interferon signaling pathway (in IPA analysis B-H P-value = 5.01E-20, Figure [6](#Fig6){ref-type="fig"}A, B). Several interferon-inducible genes involved in immune response to viral infection (including *OAS2*, *ISG15*, *STAT1,* and *ADAR*) were identified as "drivers" in this sub-network (Figure [6](#Fig6){ref-type="fig"}C) based on thesensitivity (S** ~**I**~ **)-associated network module. A)** Enrichment of the "bisque" module genes for canonical pathways based on IPA analysis, **B)** Genes in this module are involved in the interferon signaling pathway, and are negatively correlated with S~I~ (shown in green color), and **C)** Network plots of the "bisque" module in adipose of CA subjects. The red nodes are "drivers"; the size of a node is proportional to the number of nodes in the node\'s 2-layer neighborhood.

Among the 9 AA-specific and S~I~-associated modules, the "light yellow" module is most enriched for the transcripts positively correlated with S~I~ in AAs (p = 6.95E-09). The top driver gene of this sub-network (Figure [7](#Fig7){ref-type="fig"}A), *YWHAE* (14-3-3-epsilon protein), may play a role in the regulation of S~I~ by modulating the interaction between the insulin receptor


modules also showed strong enrichment for genes involved in mitochondrial carboxylic acid and branched chain amino acid metabolism. Positive correlations of these modules enriched for mitochondrial function with insulin sensitivity, and negative correlations with BMI in both AA and CA subjects, indicate that a common molecular mechanism may be involved in obesity-associated insulin resistance.

Previous studies had indicated a role of inflammatory and immune response pathway genes in S~I~ and obesity. However, these studies were restricted to Caucasian subjects. In line with these findings, we identified negative correlations between S~I~ and the "yellow" module in adipose of CA subjects (r = −0.426, p = 4.95E-04) and a strong positive correlation of this module with BMI (r = 0.607, p = 4.03E-09). This module was strongly enriched for genes involved in inflammatory response (corrected p = 1.7E-26). IPA indicated enrichmenturban geeks. But these colors will be an international crowd-pleaser.

I don not think, you are in the position to decide, who has to switch to which mobile OS?
By the way: I was thinking about Microsoft's solution. Keeping iOS6 on the iPad for my e-books and for continuing usage of a few important apps/ using Microsoft's mobil OS on the next phone.

Click to expand...

You were the one who said, "Could become a dealbreaker". You won't have a choice about iOS7, so there's only one logical conclusion, you will go to another phone operating system.

Interesting how the argument has shifted from iOS7 was designed to get rid of skeumorphism and go to a more flat design to now it's cultural. Yeah, right.

Explanation?
This version of iOS was designed especially for the


an os that is known for its customization, but rather for its simplicity and cohesiveness. So in concept, iOS isn't even aimed for Asians.

Click to expand...

op wasn't really referring to the UI or any of the customization aspects of the os or lack of for that matter. op was going on looks and ascetics and colors.

op wasn't really referring to the UI or any of the customization aspects of the os or lack of for that matter. op was going on looks and ascetics and colors.

Click to expand...

And so was I. The OS's looks, aesthetics and colors are all a part of its UI. The customization aspect of the OS directly relates to its aesthetics as well - it determines if the aesthetics part of the OS can
Pruning AI networks without impacting performance - rbanffy
https://www.ibm.com/blogs/research/2017/12/pruning-ai-networks/?utm_source=twitter&utm_medium=social&utm_campaign=AI&utm_content=nips2017
======
vanderZwan
Wouldn't it make more sense to do pruning _during_ training instead of
afterwards? That is, make the training itself involve pruning?

I remember coming across a paper four years ago showing that when using
evolutionary algorithms, simply introducing a tiny connection cost would prune
useless connections and spontaneously generate modularity:

> _we demonstrate that the ubiquitous, direct selection pressure to reduce the
> cost of connections between network nodes causes the emergence of modular
> networks. Computational evolution experiments with selection pressures to
> maximize network performance and minimize connection costs yield networks
> that are significantly more modular and more evolvable than control
> experiments that only select for performance._

[http://rspb.royalsocietypublishing.org/content/280/1755/2012...](http://rspb.royalsocietypublishing.org/content/280/1755/20122863)

Not sure if that is easily generalized to other machine learning approaches,
since I'm not working in machine learning.

~~~
Houshalter
During training the weights


keeping their value. We retrained the whole
> network using learning rate of 1e−4. After 20 epochs of training, we
> observed that the top-1 ImageNet accuracy improved by 4.3 percentage-points_

> _Sparsity is a powerful form of regularization. Our intuition is that, once
> the network arrives at a local minimum given the sparsity constraint,
> relaxing the constraint gives the network more freedom to escape the saddle
> point and arrive at a higher-accuracy local minimum. So far, we trained in
> just three stages of density (dense → sparse → dense), but regularizing
> models by intermittently pruning parameters throughout training would be an
> interesting area of future work_

[https://arxiv.org/pdf/1602.07360v3.pdf](https://arxiv.org/pdf/1602.07360v3.pdf)

I wonder if you could also receive similar results by simply turning some
connections "off" for a while, only training the rest of the connections. Then
turnlooks like the paper doesn't compare
against any of them?

------
signa11
iirc this was called optimal-brain-damage in oldish literature. it is pretty
cool actually :)

------
quotemstr
Interestingly, the brain also undergoes a thorough pruning process early in
childhood development. I wonder whether this process accomplishes something
similar to what the linked approach does for artificial neural networks.

[https://en.m.wikipedia.org/wiki/Synaptic_pruning](https://en.m.wikipedia.org/wiki/Synaptic_pruning)

------
trhway
similar work from couple of years ago
[https://arxiv.org/pdf/1506.02626.pdf](https://arxiv.org/pdf/1506.02626.pdf)

"our method prunes redundant connections using a three-step method. First, we
train the network to learn which connections are important. Next, we prune the
unim- portant connections. Finally, we retrain the network to fine tune the
weights of the remaining connections. On the ImageNet dataset, our method
reduced the number of parameters of AlexNet by a factor of 9 × , from 61
million to 6.7 million, without incurring accuracy loss. Similar experiments
with VGG-16 found that the total number


us to resolve an issue left open in our
en banc decision in United States v. Lombera-Camorlinga,
206 F.3d 882, 884 (9th Cir. 2000): whether Article 36 of the
Vienna Convention on Consular Relations1 creates judicially
enforceable rights that may be vindicated in an action brought
under 42 U.S.C. § 1983.

   Ezequiel Nunez Cornejo’s complaint seeks damages and
injunctive relief against the County of San Diego, several dep-
uty sheriffs, and various cities within the county on behalf of
a class of foreign nationals who were arrested and detained
without being advised of their right to have a consular officer
notified as required by Article 36. The district court dismissed
the action, concluding that Cornejo could not bring a § 1983
claim for violation of the Convention because it creates no
private rights of action or corresponding remedies.

  We agree with the district court that Article 36 does not
create judicially enforceable rights. Article 36 confers legal
rights and obligations on States in order to facilitate and pro-
  1
   April 24, 1963, 21 U.S.T. 77, 100-101, 569 U.N.T.S. 261.
                  CORNEJO v. COUNTY      OF   SAN DIEGO              12985
mote consular functions. Consular functions include protect-
ing the interests of detained nationals, and for that purpose
detainees have the right (if they want) for the consular post to
be notified of their situation. In this sense, detained foreign
nationals benefit from Article 36’s provisions. But


the right to
protect nationals belongs to States party to the Convention; no
private right is unambiguously conferred on individual detain-
ees such that they may pursue it through § 1983. Accordingly,
we affirm.

                                     I

   Cornejo is a national and citizen of Mexico. His First
Amended Complaint alleges that when he was arrested, San
Diego County Sheriff’s Deputies Paul LaCroix, William
McDaniel, and Jon Montion failed to inform him, and others
similarly situated whom he seeks to make part of a class, of
the individual right conferred by Article 36 and by California
Penal Code § 834c, “to contact ais no question that the Vienna Convention is self-
executing. As such, it has the force of domestic law without
the need for implementing legislation by Congress. See U.S.
Const., art. VI, cl. 2 (“[A]ll Treaties made . . . under the
Authority of the United States, shall be the supreme Law of
the Land; and the Judges in every State shall be bound
thereby . . . .”); Foster v. Neilson, 27 U.S. (2 Pet.) 253, 314
(1829); Medellín v. Dretke, 544 U.S. 660, 686 (2005)
(O’Connor, J., dissenting) (citing Head Money Cases, 112
U.S. 580, 598-99 (1884)). But “the questions of whether a
treaty is self-executing and whether it creates private rights
and remedies are analytically distinct.” Id. at 687; Restate-
ment (Third) of Foreign Relations Law of the United States
§ 111 cmt. h (hereinafter Restatement). “While a


by virtue of the
Vienna Convention exist for the benefit of [the sending State],
not for him as an individual.”).7

   [3] As Cornejo’s claim is pursuant to § 1983, which pro-
vides a vehicle for seeking relief for violation of the “Consti-
tution and laws,”8 we are guided by the Supreme Court’s
treatment of the analogous issue of enforcement of personal
rights arising under federal statutes through § 1983. It is clear
from Gonzaga University v. Doe, 536 U.S. 273, 283 (2002),
that “it is rights, not the broader or vaguer ‘benefits’ or ‘inter-
ests,’ that may be enforced under the authority of that sec-
tion.” Thus, an “unambiguously conferred right” phrased in
terms of the person benefitted is essential before a statute —
and by extension, a treaty having the force of federal law —
may support aCongress. And
it is how the treaty has been understood in practice by all its
signatories. While Article 36 may also benefit an individual
detainee when properly followed, benefit is not enough to
pass the Gonzaga test. We therefore agree with the district
court that Cornejo cannot state a claim under § 1983.

   AFFIRMED.

D.W. NELSON, Senior Circuit Judge, dissenting:

  The question that we should address, in accordance with
Supreme Court precedent in Gonzaga University v. Doe, 536
U.S. 273 (2002), is whether Article 36(1)(b) of the Vienna
Convention on Consular Relations (“Vienna Convention”),
Apr. 24, 1963, 21 U.S.T. 77, T.I.A.S. No. 6820, 596 U.N.T.S.
261, was intended to confer individual rights that would be
presumptively enforceable under 42 U.S.C. § 1983. Instead of
addressing this question, the majority relies on an erroneous

under Article 36, paragraph 1. The


which was attached to the Letter of Submittal.
The Report stated:

    The solution adopted by the Conference to the prob-
    lem of adjusting the notification obligations of the
    receiving State to the right of the individual con-
    cerned to request notification lies in the final sen-
    tence of subparagraph 1(b). That sentence requires
    authorities of the receiving State to inform the per-
    son detained of his right to have the fact of his
    detention reported to the consular post concerned
    and of his right to communicate with that consular
    post.

The majority does not address these contemporaneous state-
ments. Given thatOF   SAN DIEGO             13013
ment’s position. Maj. Op. at 12999. Specifically, the majority
explains “there is no indication that States intended the
enforcement of a ‘right’ to consular notification in the courts
of the receiving State.” Id. The reasoning again demonstrates
the majority’s confusion with the Gonzaga standard. Gonzaga
only requires an intent in the Vienna Convention to create a
right, not an intent to enforce a right.2 Given this roundabout
reliance on the travaux préparatoires, I believe it is important
to show that it also supports the conclusion that Article
36(1)(b) confers an individual right.3

   The original text of Article 36(1)(b) stated:

      The competent authorities shall, without undue
      delay, inform the


'Theoretical study of quantum emitters in two-dimensional silicon carbide monolayer'
---

INTRODUCTION
============

Two-dimensional (2D) materials have recently received much attraction in the scientific communities because of their unique properties and extensive applications. A prominent aspect of 2D materials is their applications in quantum technologies where single photons are essential. Observation and investigation of single photons in 2D materials such as $h$-BN, transition metal dichalcogenides, WO$_{3}$, and GaSe [@Toth2019; @Tran2017; @Palacios-Berraquero2017; @He2015; @Tonndorf2017; @Branny2016; @Chakraborty2016], has raised a great interest toward this class of materials in the field of single-photon emitters (SPE). SPE’s in 2D materials are applicable in many quantum technologies ranging from quantum nanophotonics to quantum sensing and quantum information processing [@Aharonovich2017]. In such materials, the 2D nature of the host considerably improves the photon-extraction efficiency, provides more control over thethe Huang-Rhys factor and the photoluminescence spectrum for some selected defects. The values of the HR factor are in the range of 0.74 to 3.32 (Debye-Waller factor of $48\%$ to $4\%$). Our ab-initio analysis demonstrated that Stone-Wales defects (SW, SW-Si$_{\text{C}}$, SW-C$_{\text{Si}}$) in neutral and positive charge states are capable of emitting single photons. The group theory analysis for the SW neutral and charged defects predicted the polarization of radiative and non-radiative transitions, respectively. Increasing dipole transition probability in pure SW defect with lower symmetry convinced us of having brighter emissions in these defects. Our analysis on the spin-orbit interaction suggests that non-radiative transition through the shelving states is also possible. The plotted PL spectra of the transitions with the highest value of the HR factor suggest the following


is threatened by morning light." "Of course." "This loyalty of yours inspires you to protect Spain at any cost," "but killing the inquisitor is suicide." "Europe would have my head." "I, for one, am not ready to die yet." "Are you?" "I will die for Spain." "I know, Conquistador." "I know." "And this bravery of yours, it may save us yet." "For Spain has a plan." "There is hope." " There's hope?" " Father." "I am Father Avila of her royal Franciscan order." "Our allegiance remains with Spain." "Father." "Guards, leave us." "Conquistador," "I am going to tell you the true reason why the inquisitor pits cross against crown." "One year ago, Father Avila returned from the jungles of New Spain with a secret so great, it promisedx-ray referrals for any condition by each GP during the 12 months after delivery of intervention/control. The number of x-ray referrals is therefore taken as the primary outcome for the economic evaluation. Observations from actual clinical practice were not available for 'advice to stay active' or 'advice to take bed rest'. Observations on each of the key behaviours consistent with the CPG (imaging referral, advice to stay active and advice to take bed rest) at 12 months after delivery of intervention/control were, however, available in *simulated* clinical practice. Specifically, GP adherence in simulated practice for each of the key clinical behaviours was measured by GP responses to a series of four acute LBP patient vignettes. We conducted supplementary analyses for adherence to the guideline in simulated practice as


measured by these vignettes.

In order to evaluate whether any increase in adherence to the CPG has come at a reasonable price, we also measured differences in cost between the treatment and control groups. Variation with respect to cost within the trial period derives from (i) development of the IMPLEMENT intervention, (ii) delivery of the IMPLEMENT intervention, (iii) delivery of the control intervention, and (iv) any subsequent changes in practice and subsequent health effects. A summary of unit costs by category of resource use is provided in [Appendix S1](#pone.0075647.s001){ref-type="supplementary-material"}. Data sources for (i), (ii), (iii) and (iv) are detailed in Appendices S2 to S5 respectively. Total costs for each individual provider were calculated by summing together provider-level data with respect to health service utilization, total development cost per providerand (ii) additional costs (savings) per additional consultation adherent to the key messages of the CPG in simulated practice.

Point estimates for incremental cost-effectiveness were calculated as the average incremental effect of treatment status on total cost per GP divided by the average incremental effect of treatment status on the relevant outcome. Confidence intervals around the incremental cost-effectiveness ratio were derived by application of Fieller\'s Theorem using iprogs.do [@pone.0075647-Glick1]. Cost-effectiveness acceptability curves (CEACs) were used to visualise uncertainty associated with the decision to replace the control intervention with the evaluated intervention.

Results {#s3}
=======

Participants {#s3a}
------------

The study sample comprised 112 GPs drawn from the 92 included practices. Forty-five practices (59 GPs) were randomized to the intervention group and 47 to the control group (53 GPs). Of the 59 GPs randomized to the


strata and pre-specified confounders, adherence in simulated practice was statistically significantly more common in the intervention group than in the control group with respect to x-ray (OR = 1.76, p = 0.045), imaging (OR = 2.36, p\<0.001) and activity (OR = 4.49, p = 0.001). Non-adherence to the CPG with respect to bed-rest was very uncommon in both treatment and control groups; resulting in very large standard errors and large magnitude but statistically insignificant treatment effects (OR = 2.91, p = 0.354). Incremental effects reported in [Table 3](#pone-0075647-t003){ref-type="table"} suggest that exposure to the intervention increased the probability of adherence by 0.099 (95%CI: −0.002, 0.201; p = 0.056) in the case of x-ray; by 0.177 (95%CI: 0.068, 0.286; p = 0.002) in the case of imaging; and 0.297 (95%CI: 0.210, 0.384; p = 0.000) in the case of activity. Applying these probabilities to 25^th^ percentile estimates of the number  \$4315 (3027)                                                          \$4617 (2998)                                       0.93 (0.70, 1.22)   −\$345.27 (676)
  No dev cost[5](#nt124){ref-type="table-fn"} \@5%              34 (44)


example, that GPs were not paid an honorarium for their attendance at workshops (though they did receive continuing medical education (CME) points for their participation). While those GPs who participated without monetary compensation clearly felt that the improvement in their practice and attendant CME points were sufficient compensation for their time, many GPs might only be willing to participate for a fee and some might be unwilling to participate at any price. Our base-case analysis assumes a participation rate of 2.6% of the current cohort of Australian GPs in any wider roll out. It is likely that participation rates will differ from context to context due, for example, to stronger or weaker incentives for CME (versus additional throughput or leisure) under fee-for-service versus capitated payment. Where higher orDM SDF SDF JEM DAO SEG. Lead investigator of the funding application: SEG. Designed and/or delivered the intervention: SDF JEM DAO SEG. Acquired the data: SDF. Wrote the first draft of the paper: DM. Contributed to revisions of the manuscript and approved the final version: DM SDF JEM DAO SEG.


dog to take a flying leap off a bed that's five to six times higher than he stands is an act of courage, and a recipe for injury," says Stephen Crane, an academic animal doctor and diplomat of the American College of Veterinary Surgeons.

The peril is too new to have generated peer-reviewed veterinary research. But the problem is evident in the white-hot popularity of a relatively new product: pet stairs, specifically designed to lead Fido from bed to floor by land rather than air.

Wednesday, December 3, 2008

I get calls daily about pets (particularly dogs) eating things they shouldn't. Toys, trash, wrappers, chocolate, bottle caps, squirrels, undergarments, even feces...the list goes on. Amazingly, for all of the things that dogs eat, most of them do just fine. I evenare the 3 most common comments related to finances and pets. I know there are many more, several of which I havn't touched on for time considerations. Any in the veterinary field, feel free to add your most favorites to the comments page.

On a closing note, let's just say I have gotten really good at making estimates for even the most mundane of procedures and "encouraging" prompt payment despite not getting any training in that at school. Maybe they just figure that is the best kind of lesson to learn "on the job" because it is difficult to teach. Still, I think it would be very useful if some "bounty hunter" classes were included in the curriculum. Maybe right after learning how to play the invisible violin.

Sunday, August


pictures of a new visitor to the yard that I haven't seen before. This is a pair of Brown Thrashers (Toxostoma rufum). It is a neat looking bird, and is related to catbirds and mockingbirds. They were foraging in the backyard, digging around in the mulch.

But now, that longtime bastion of machismo is overwhelmingly female. Changes in culture, pharmacology and even pet preferences have led to one of the most dramatic gender shifts in the workforce.

Eighty percent of the applicants accepted this month by the University of California-Davis' prestigious veterinary school are women. Similar numbers are reported by other vet schools around the country.

Plenty of other once male-dominated fields, such as law and medicine, are experiencing a surge in female students. But nowhere has the gender shift beenthe Sultan of Sulu, who was known for shipping the elephants around as gifts for various other rulers, sent some to Borneo where they escaped and and have become their own subspecies. Here is a link to the WWF article.

According to the WWF: "Borneo pygmy elephants are smaller than other Asian elephants. The males may only grow to less than 2.5 meters, while other Asian elephants grow up to 3 meters. They also have babyish faces, larger ears, longer tails that reach almost to the ground and are more rotund. These elephants are also less aggressive than other Asian elephants." Sadly, they do remain highly endangered with an estimated wild population around 1,000.

Thursday, April 10, 2008

My brother forwarded on this scary story about PetSmart being sued due to


than 1,100 active eagle nests were counted last year in Florida, compared with just 88 in 1973. And the state continues with its land and habitat plans designed to protect the bald eagle."

That is definitely good news, and shows that the eagle has made a real comeback all over the country. Interestingly, many seem to think that this is a step closer to lessening penalties for killing bald eagles. What this means is that less wildlife department resources will be directed specifically towards this bird, and more can be funneled to programs to protect other endangered species. The bald eagle will likely always remain a protected species.

In many respects, the bald eagle can be considered a "flagship species" meaning that they are (1) an easily recognizable national symbol,Q:

Scan text file for line containing a given string and replace the line with another string

I want to scan my file for line that contains a particular string "black=" and if there is a match replace it with "blah blah" but I don't know how to do that. Here is what I tried but it does not work.
Dim myStreamReaderL1 As System.IO.StreamReader
myStreamReaderL1 = System.IO.File.OpenText("C:\File.txt")
myStreamReaderL1.ReadLine()
If myStreamReaderL1.ReadLine.Contains("black=") Then
    Button2.Hide()
Else
    Return
End If

A:

Assuming the input file is not huge, you can read the whole file into a string and change all instances of black= to blah blah
        Dim myStreamReaderL1 As System.IO.StreamReader
        Dim myStream As System.IO.StreamWriter


court, which on March 21 this year completed the hearing in a record five months and sentenced eleven accused to life imprisonment.

However, Jayant Sinha had questioned the manner in which the police investigated the case and demanded a CBI inquiry in April this year.

All accused went to the Jharkhand High Court from where eight of them got bail on June 29, exactly a year after the incident.

Justifying the welcome accorded to the convicts, Amardeep Yadav said that Sinha always believed that they were innocents and framed in the case. “That’s why he provided legal and monetary assistance to them in his personal capacity. There is nothing wrong in supporting innocent people.”

Referring to the three other convicts, he expressed hope that they too would get bail from the HighAntioxidant properties of isolated compounds from banana rhizome.
In this study, we attempted to explore banana rhizome (BR) as a source of natural bioactive compounds. Dried BR powder was subjected to sequential extraction using solvents with increasing polarity and studied for antioxidant activities. Chloroform and acetone extracts were selected for isolation and identification of bioactive compounds because of their high antioxidant properties. Antioxidant activity guided fractionation of these extracts yielded 3 compounds. The spectroscopy studies revealed the identity of isolated compounds as 4-epicyclomusalenone, cycloeucalenol acetate and chlorogenic acid. Polyphenolic compound chlorogenic acid and triterpenoid compounds, 4-cyclomusalenone and cycloeucalenol acetate displayed multifunctional antioxidant activity. The isolated compounds namely 4-epicyclomusalenone, cycloeucalenol acetate and chlorogenic acid have demonstrated their antioxidant properties in different in vitro assay models. The present study indicated that


you think would make the best president."

Romney announced Friday he would vote for Cruz in the Utah caucuses, saying in a Facebook post that the Texas senator was the only candidate remaining that could stop Trump. The vote was not an endorsement.

Instead, Romney said backing Cruz was the best way to deny Trump the requisite delegates needed to secure the nomination before the Republican convention. Should that happen, it would force an open convention -- and an opportunity to deny Trump the nomination, even if he held the most delegates.

Read MoreCluster synthesis and direct ordering of rare-earth transition-metal nanomagnets.
Rare-earth transition-metal (R-TM) alloys show superior permanent magnetic properties in the bulk, but the synthesis and application of R-TM nanoparticles remains a challenge due to the requirement of high-temperature annealing above about 800 °C for alloy formation and subsequent crystalline ordering. Here we report a single-step method to produce highly ordered R-TM nanoparticles such as YCo(5) and Y(2)Co(17), without high-temperature thermal annealing by employing a cluster-deposition system and investigate their structural and magnetic properties. The direct ordering is highly desirable to create and assemble R-TM nanoparticle building blocks for future permanent-magnet and other significant applications.


same result with both cards)
Cycling through my sticks of ram in the first slot.
Installing each card in each PCIE slot

The machine worked just fine.. he used it daily to game and stream before he upgraded. My gut is kind of telling me that Occam's Razor applies here, and I just may have purchased two dead video cards.
Does anyone have any other ideas?

A:

I purchased a USB thumb drive and used it to install the latest BIOS for this motherboard. The machine now boots without error.

 "Description": "DBName"
        }
    },
    "Outputs": {
        "Url": {
            "Value": {
                "Fn::Sub": "postgres://${DBUsername}:${DBPassword}@${Instance.Endpoint.Address}:${Instance.Endpoint.Port}/${DBName}"
            }
        }
    },
    "Resources": {
        "Instance": {
            "Type": "AWS::RDS::DBInstance",
            "DeletionPolicy": "Retain",


This invention relates to a micro-controller and particularly to a a micro-controller for water discharge.
Conventional water timer has the following disadvantages:
1. The water flow detector disposed on the conventional water timer is mechanical type therefore, as the water pressure is beyond the predetermined valve, the water flow thereof can not be precisely controlled.
2. Since lacking the automatic timing system, the control valve of the conventional water timer can only be operated manually.
It is, therefore, an object of the present invention to get rid of and reduce severity of the above-noted drawbacks.Interaction of fibroblasts on polycarbonate membrane surfaces with different micropore sizes and hydrophilicity.
Surface topography appears to be an important but often neglected factor in implant performance. In this study, fibroblasts were cultured on a range of porous polycarbonate (PC) membranes with well defined surface topography (track-etched micropores, 0.2-8.0 microm in diameter) and wettability gradients. The wettability gradient on the PC membrane surfaces was produced by treating the surfaces with corona from a knife-type electrode whose power increased gradually along the sample length. The PC membrane surfaces were characterized by scanning electron microscopy (SEM) and the water contact angle measurement. Fibroblasts were cultured on the corona-treated PC membrane surfaces with different micropore sizes for 1 and 2 days. The cells attached on the membrane surfaces were examined by SEM


and the cell density on the surfaces was estimated by counting the number of attached cells along the wettability gradient. It was observed that the cells were adhered and grew more on the hydrophilic positions of the membrane surfaces than the more hydrophobic ones, regardless of micropore size. It was also observed that cell adhesion and growth decreased gradually with increasing micropore size of the membrane surfaces. It seems that the cell adhesion and growth were progressively inhibited as the membrane surfaces had micropores with increasing size, probably due to surface discontinuities produced by tract-etched pores. On the membrane surfaces with smaller micropore sizes, the cells seemed to override these surface discontinuities.study are available from the corresponding author upon reasonable request.

The research protocol was reviewed and approved by the National Ethics Committee of Burundi in September 2013. Authorisation from the Ministry of Public Health for the study was provided in May 2014.

Not applicable.

The authors declare that they have no competing interests.


     Acc_ALWAYS = 16  /* the usual hack     */
   }
   AMD64CondCode;

extern HChar* showAMD64CondCode ( AMD64CondCode );

/* --------- Memory address expressions (amodes). --------- */

typedef
   enum {
     Aam_IR,        /* Immediate + Reg */
     Aam_IRRS       /* Immediate + Reg1 + (Reg2 << Shift) */
   }
   AMD64AModeTag;

typedef
   struct {
      AMD64AModeTag tag;
      union {
         struct {
            UInt imm;
      Ain_LoadEX,      /* mov{s,z}{b,w,l}q from mem to reg */
      Ain_Store,       /* store 32/16/8 bit value in memory */
      Ain_Set64,       /* convert condition code to 64-bit value */
      Ain_Bsfr64,      /* 64-bit bsf/bsr */
      Ain_MFence,      /* mem fence */
      Ain_ACAS,        /* 8/16/32/64-bit lock;cmpxchg */
      Ain_DACAS,       /* lock;cmpxchg8b/16b (doubleword ACAS, 2 x


MulL;
          /* amd64 div/idiv instruction.  Modifies RDX and RAX and
	     reads src. */
         struct {
            Bool     syned;
            Int      sz; /* 4 or 8 only */
            AMD64RM* src;
         } Div;
//..          /* shld/shrd.  op may only be Xsh_SHL or Xsh_SHR */
//..       violate the terms of use may have their comments removed or all of their content blocked from viewing by other users without notification.
The Kassandra Project doesn't control the linked web pages: we are no responsible for their content.


crowdfunding in 1929. It turned out badly, so now we
have the SEC and many restrictions on equity offerings.

~~~
akg_67
I believe you meant "Prosper" and not "Lending Club". LC never allowed lenders
to set the rates, it was Prosper. LC started out as Facebook app for lending.

Equity crowdfunding was hobbled by SEC equity crowdfunding regulations
influenced by special interest groups. The restriction on max amount non-
accredited investors can invest to very low amount doesn't help investors in
diversifying across lot of companies and make follow up investment in winners.

Also, equity crowdfunding platforms haven't done the favor to the industry by
creating poor investor-unfriendly terms like no direct claim/ownership of the
company, no voting rights, no access to ongoing financials and inability to do
follow up investments. A better structure would have been that followed by
angels/VCs.

~~~
pmorici
The fundamentalAll relevant data are within the manuscript and its Supporting Information files.

Introduction {#sec001}
============

Deviations between intended and delivered radiotherapy dose distributions can potentially lead to severe clinical consequences \[[@pone.0212412.ref001]\]. In order to ensure treatment quality and patient safety, it is vital for comprehensive quality assurance (QA) programs to be implemented \[[@pone.0212412.ref002],[@pone.0212412.ref003]\]. Patient-specific quality assurance (PSQA) procedures are an essential sub-component of such a program. The main elements of PSQA include verifying that 1) the treatment planning system (TPS) correctly models the radiation fluence produced by the treatment machine, 2) the machine performance is acceptable to deliver the intended fluence, 3) the TPS calculates an accurate representation of the dose delivered to the patient, and 4) the plan data, which is transferred between the TPS and the treatment delivery system


PSQA program that relies heavily on dose plane measurements in a homogeneous, water-like phantom.

Due to the scarcity of beam time for quality assurance in some modern proton facilities, a process which makes most efficient use of the treatment room is desirable. Recently, new techniques have been introduced with the goal of improving the efficiency and utility of patient-specific QA. In particular, log-file analysis has been implemented in proton clinics. For the utilization of log files to be of any value, experimental verification between the log file data and the position of delivered spots at isocenter must be established \[[@pone.0212412.ref022],[@pone.0212412.ref023]\]. The additional information provided by log files has been used to supplement, rather than replace, more traditional phantom-based measurements \[[@pone.0212412.ref024]\]. For example, log files of actual delivered spot positionsa different day than the plan represented by [Fig 4](#pone.0212412.g004){ref-type="fig"}. There are a large number of systematic deviations in the y direction (black circles) which very closely approach, but do not exceed, one of the regular systematic tolerance lines in part a). This is indicative of a plan which technically passes this aspect of the patient-specific QA process, but would also trigger a deeper investigation into machine performance.

![Projected spot position deviation histograms for a sub-optimal plan delivery.\
The systematic and random components of the error (Eqs [1](#pone.0212412.e001){ref-type="disp-formula"} and [2](#pone.0212412.e002){ref-type="disp-formula"}) are shown on log-linear histograms. Spots subject to regular tolerances (a) are separated from those governed by expanded tolerances (b). The close approach of the y systematic data points to their corresponding tolerance (black line) suggests the potential for triggering


by reducing the number of times each field is delivered from two (due to dose plane measurement depths) to one. Because beam-modifying range shifters are not required to be in place for log-file QA deliveries and analysis, removing the need for the physicist to add/remove these between fields also contributes to the time savings in this final category.

Discussion {#sec004}
==========

Historically, unacceptably large failure rates have been observed in photon IMRT QA \[[@pone.0212412.ref034]\]. This is likely due to issues associated with modeling the delivered photon fluence as opposed to inaccuracies of the dose calculation algorithm in the water-like phantom. As radiation delivery technology and TPS modeling has improved, the frequency of plans which fail IMRT QA has decreased \[[@pone.0212412.ref035]\]. Nevertheless, significant challenges in modeling photon fluence persist due to difficultiesname high over all," &c.

These lines were not written by _John_, but by _Charles Wesley_. Here is
the proof:

1st. A hymn of which the stanza quoted is the first, appears (p. 40.) in
the _Collection of Hymns_ published by John Wesley in 1779; but in the
preface he says, "but a small part of these hymns are of my own composing."

2nd. In his _Plain Account of Christian Perfection_, he says:

    "In the year 1749, my brother printed two volumes of _Hymns and Sacred
    Poems_. As I _did not see them_ before they were published, there were
    some things in them which I did not approve of; but I quite approved of
    the main of the hymns on this head."--_Works_,


who have imbibed the milk of learning
    from these places. The epithet has lately been transplanted to the
    United States of America.]

       *       *       *       *       *

Replies.

ALEXANDER CLARK.

(Vol. viii., p. 18.)

In communicating a few particulars about Alexander Clark, I must disappoint
your correspondent PERTHENSIS; _my_ subject answering in no respect to
Peter Buchan's "drucken dominie," the author of the _Buttery College_.
Alexander Clark, who has fallen in my way, belongs to the class of "amiable
enthusiasts;" a character I am somewhat fond of, believing that in any
pursuit a dash of the latter quality is essential toLondon: British MPs are set to open an inquiry into Britain’s use of drones to kill militants.

The investigation will be carried out by the Commons Defence Select Committee into country’s use of unmanned aerial vehicles.

It is believed that scrutiny of the use of the unmanned weapons could shed light on the “secret war” being waged remotely by the US against terror suspects in Pakistan, Yemen and Somalia.

The Commons Defence Select Committee will consider the tactic, and MPs and peers could also debate Britain’s drone policy and the ethics of attacking people remotely, the Telegraph reports.

Ministers are likely to come under pressure to disclose whether they are sharing intelligence with the US to help the CIA with its drone attacks, the report said.

“An unmanned aerial vehicle is the same