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Decide on what issues the company is attempting to address. Although in almost allsurveillance aircraft.

“All nations must learn from the recent Marawi conflict and the Philippines’ experience,” said Australian Defence Minister Marise Payne, adding Canberra and Manila will host a post-conflict seminar to learn from the five-month Marawi conflict.

About 80 soldiers from Australia’s mobile training team will be deployed in local bases in the Philippines to train army and marine units in urban counter-terrorism warfare, said Payne on the sidelines of an ASEAN Defence Ministers Meeting in Clark, a former U.S. air force base.

“The practical training the Australian Defence Forces (ADF) will provide will ensure the Philippines defense force is better able to counter the brutal tactics being employed by terrorists,” Payne told a news conference.

“The spread of Daesh-inspired (Islamic State) terrorism is a direct threat to Australia and its interests


Webe are looking to introduce an unlimited plan for RM80/month. And when they say unlimited, they truly mean unlimited as the page indicates that users who subscribe to this plan will get unlimited 4G Internet, unlimited calls and unlimited SMS. The plan also allows for shared lines (up to 3 lines) which could mean that up to four different lines sharing one unlimited quota.

Comparatively, an existing RM80 plan like Celcom’s FIRST Gold plan only gives you 10GB of data (split between weekends and weekdays).

However, as this is only a test page, we do urge you to take this with a grain of salt as its seems too good to be true. These numbers could only be placeholder figures and not reflect the final plan’s pricing. Either way, thisto battle for them.

Weaknesses:

For as strong of a personality that he is in the clubhouse, his rotations were suspect at times and he ended up feuding with Marc Gasol in an attempt to end a losing streak. This resulted in his firing and raises some of the concerns that David Blatt has with player relationships, but he has nowhere near the same pedigree as Blatt. He was given a rather unfair shake in Memphis following the injury of Mike Conley and the departure of Zach Randolph, but his behavior was unacceptable towards the team’s best player.

Notable Exclusions:

Mark Jackson: I was really turned off by the way that he handled the clubhouse and turned players against each other.

Mike Woodson: I love Woody, but he’s no better than an average


that are going to help our InStyle editors survive #NYFW and the rest of winter.

1.
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Courtesy

2.
MEGGAN CRUM, ACCESSORIES DIRECTOR

2. Uniqlo jacket ($70; uniqlo.com): "The key here is the down layer, which I wear underneath. It keeps me warm without looking too casual or bulky, as I trek through the cold and snow from show toPositive

Negative

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a beautiful rose bush.”

Here’s to beautiful messes.

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Like this:

As if a driving trip from Illinois to Pennsylvania weren’t long enough, this message greeted us just west of South Bend, Indiana as we traveled the Indiana Toll Road on our most recent trip home and back. By the time I pulled the map out, our first chance at an alternate route had passed. When the sign warned us again just before the second alternate route, my husband and I mutually decided to stick with the Toll Road and see what was ahead.

Lesson learned: If the department of transportation tells you to take another route, obey!

As we approached the final exit before the accident, traffic came to a standstill because both eastbound lanes were closed and all traffic was beingdon’t take seriously.

Proverbs 3:5-6 says, “Trust in the Lord with all your heart and lean not on your own understanding; in all your ways acknowledge him and he will make your paths straight.” (NIV)

I felt like this could have been painted on our car after the South Bend delay. We could have trusted the DOT signs and taken another route, avoiding the delay and the frustration of having to navigate multiple detours. Instead, we plowed ahead based on our own understanding of the situation, which at the time wasn’t much. Life is the same way. God wants to show us which way to go, but if we choose to follow our own ways, we might end up stuck, delayed in our dreams, frustrated, regretful or far off the


discontinuous skeletal method.

Very recent works have shown other possible approaches to the design of high-order polytopal discretizations combining element-based and skeletal unknowns. A first example of arbitrary-order discontinuous skeletal methods are primal [@Di-Pietro.Ern.ea:14; @Di-Pietro.Droniou.ea:15] and mixed [@Di-Pietro.Ern:16] Hybrid High-Order methods. Hybrid High-Order methods were originally introduced in [@Di-Pietro.Ern:15*1] in the context of linear elasticity. The main idea consists in reconstructing high-order differential operators based on suitably selected DOFs and discrete integration by parts formulas. These reconstructions are then used to formulate the local contributions to the discrete problem including a cleverly tailored stabilization that penalizes high-order face-based residuals. A study of the relations among primal Hybrid High-Order methods, Hybridizable Discontinuous Galerkin (HDG) methods, and High-Order Mimetic Finite Differences [@Lipnikov.Manzini:14] can be found in [@Cockburn.Di-Pietro.ea:15], where the corresponding numerical fluxes in the spirit of({\vec{\sigma}}_h,{\vec{\tau}}_h)+(\opdiv{\vec{\tau}}_h,u_h)
    +\sum_{T\in\Th}\sum_{F\in\Fhi[T]}({\vec{\tau}}_h\SCAL\normal_{TF},\lambda_h)_F
  &=0&\qquad&\forall{\vec{\tau}}_h\in{\mathbb{RT}^{0,\mathrm{d}}}(\Th),
  \\
  -(\opdiv{\vec{\sigma}}_h,v_h)&=(f,v_h)&\qquad&\forall v_h\in\Poly{0}(\Th),
  \\
    \sum_{T\in\Th}\sum_{F\in\Fhi[T]}({\vec{\sigma}}_h\SCAL\normal_{TF},\mu_h)_F&=0&\qquad&\forall\mu_h\in\Lambda_h.
\end{alignedat}
\label{eq:RThyb}$$ The usual way of solving problem  is to invert the (block-diagonal) mass matrix corresponding to the variables in ${\mathbb{RT}^{0,\mathrm{d}}}(\Th)$ and to consider a statically condensed linear system of the form $$\mathbf{A}\mathsf{\Lambda}=\mathsf{F}
\label{eq:RTstatcond}$$ where $\mathbf{A}$ is symmetric and positive definite.

Let now ${\mathbb{NC}}(\Th)$ be the nonconforming Crouzeix–Raviart space of [@Crouzeix.Raviart:73] on the same mesh $\Th$; i.e., the space of piecewise affine functions which are continuous on the midnodes of the interelement edges. Denoting by ${\mathbb{NC}}_0(\Th)$ the subspace of ${\mathbb{NC}}(\Th)$ with DOFs lying on $\partial\Omega$ set to zero, the approximation of problem  reads: Find $u_h\in{\mathbb{NC}}_0(\Th)$ such that $$(\GRADh u_h,\GRADh v_h)=(f,v_h)\qquad\forall v_h\in{\mathbb{NC}}_0(\Th),
\label{eq:nonc}$$ where $\GRADh$ denotes the broken gradient operator on $\Th$. The matrix form of  is


sensitivity. The limits of quantification for each enantiomer are 5.00 microg/L from 0.5 mL whole blood and 7.50 ng/g (ppb) using 0.333 g brain tissue, respectively. Similar assay specifications have been derived for the two enantiomers. The method has been validated for the analysis of blood samples from low and high dosed preclinical pharmacokinetic and toxicokinetic studies, corresponding to two analytical working ranges like e.g. 5.00 to 1000 microg/L and 200 to 40000 microg/L (0. 200 to 40.0 mg/L). For rat brain tissue the validated concentration range is 7.50 to 750 ng/g (ppb).and downloading multiple files from webpages using filters and other tools to aid in the process.

What we can do and did do is bring the mass selection, organizing (renaming masks, etc) and queueing tools of DownThemAll! over to the WebExtension, so you can easily queue up hundreds or thousands files at once without the downloads going up in flames because the browser tried to download them all at once.

Closing Words

The WebExtension version of DownThemAll supports the core functionality of the legacy version for the most part but will lack lots of features that made DownThemAll one of the most popular Firefox add-ons. Fans and long-time users of the add-on will give it a try probably regardless of that.

Now You: What is your take on the development?

Summary Article Name


it should have nilpotent $Q$ and exact $Q$-invariance, which the current model satisfies. Since the SUSY is not broken in the perturbation if it is not broken in the tree level, a way of observing SUSY breaking due to non-perturbative effects is very important. Usually, the Witten index provides such a method but in this system, two-dimensional $\mathcal{N}=(2,2)$ pure super Yang-Mills, it is not available. What we know without numerical simulations is an argument by Hori and Tong that SUSY is probably spontaneously broken in this system [@Hori:2006dk].

What we measure is the ground state energy using the Hamiltonian as the order parameter. As well known, vacuum expectation value of the Hamiltonian is zero if and only if the SUSY is not broken. The advantage of using the Hamiltonianoutside those facilities looking to purchase [the product].”

Twenty-nine states and the District of Columbia currently have laws legalizing marijuana in some form.

Next year is expected to be a particularly big year for the weed business because at least eight of the 11 states that passed medical or recreational cannabis laws in 2016 will begin selling it. So, in 2018, one in five Americans will live in an area where it’s legal to get high.

In addition, Canada is expected to legalize marijuana for recreational use on July 1, 2018. That’s expected to result in tens of billions of dollars in additional annual revenue for the cannabis sector, creating jobs and more business opportunities.

It appears there will be plenty of investors wanting in on the action. In an exclusive Yahoo


an added pinch point that we don't need at the moment," he said.

"We're going to get lower and lower prices."

Australian property prices in retreat

AMP chief economist Shane Oliver says he agrees with the underlying "sensible" logic of SQM's research and thinks there will be downward pressure on property prices because of Labor's changes.

He worries that with property prices already falling, now might not be the time to be making changes to tax breaks for property investors.

"The risk is that it just adds to the perfect storm that's around property prices at the moment. That it adds to the uncertainty and pushes prices down even further."

When Opposition Leader Bill Shorten announced Labor's policy to scrap negative gearing for existing property purchases and halve the capital gains discount in February2016, Australian property was running hot.

The year before, in 2015, property prices had risen an average 8.7 per cent and showed no sign of slowing down.

At the time Mr Shorten promised to "put the great Australian dream back within reach of working and middle class Australians, who have been priced out of the market for too long."

Fast forward to 2019, and it's a completely different story.

Nationally prices fell by 5.1 per cent last year, with the consensus view that prices will continue to fall this year.

Rhianna Woolnough and partner Michael Moragn are hunting for their first home but are worried about rising house prices ( ABC News: Mitchell Woolnough )

First home buyers still struggling to buy in

Rhianna Woolnough and partner Michael Morgan are on the hunt for their


1. Technical Field
This disclosure is directed to integrated circuits, and more particularly, to the detection of power transients within integrated circuits.
2. Description of the Related Art
Integrated circuits (IC's) are typically tested at the end of the manufacturing process in order to verify their correct operation and to identify parts that are faulty. In addition, IC's may be tested during the design phase in order to find flaws in the design that are not apparent before it is committed to silicon.
Many different failure mechanisms may cause a particular instance of an IC to fail a test. In some cases, the failures may be hard failures. Examples of hard failures include faulty or inoperative transistors, unintentional short circuits, unintentional open circuits, and so forth. In other cases, failures may bethe effect of a combined oral contraceptive (OC) versus placebo, on well-being and mood. Over the course of 3 months, women in the OC group reported significantly lower global scores on self-reported well-being compared with placebo, driven by the negative effect of OCs on scales measuring positive well-being, self-control, and vitality. However, mean depression scores did not differ significantly across groups and time points in self-reported Beck Depression Inventory (BDI) scores.

Another Swedish group took a more unconventional approach in their double-blind RCT: they aimed to sample participants more representative of HC-users in the general population, thus deciding not to exclude women with previous or ongoing psychiatric disorders and respective medication, nor any women with a history of OC-use-associated onset of depressed mood \[[@CR16]••, [@CR17]••\]. In total, over 200 women


The OC group also showed reduced BOLD response of the left insula, the left middle frontal gyrus, and the bilateral inferior frontal gyri compared with the placebo group in response to negative emotional face stimuli \[[@CR28]\]. However, these differences in BOLD response occurred in brain regions that are otherwise activated for positive or salient emotional stimuli.

Specifically for fear processing, OC-induced effects on neural activation have been reported, such as enhanced activation of the fear network in OC-users compared with naturally cycling women, particularly in the insula and the dorsal anterior cingulate cortex (ACC) \[[@CR29]•\]. These activation differences were independent of the valence and arousal ratings of the presented traumatic videos, which were similar between groups. Consistent with these findings, another study \[[@CR30]\] found increased emotional arousal indicated byuse HC-intake as a control variable for a low ovarian hormone state. This is only partly true. Indeed, the assessment of peripheral plasma levels of endogenous ovarian hormones, i.e., estradiol and progesterone, reveals low hormone levels. However, if a woman continuously takes exogenous ovarian hormones, either in an oral or non-oral route of administration, these exogenous ovarian hormones cross the blood-brain barrier \[[@CR78], [@CR79]\], a fact that should be considered in the interpretation of neuroimaging findings. Yet, this is only one aspect to consider: We do not yet know how a high exogenous and a low endogenous hormonal state interact, e.g., via feedback loops and cellular signaling, and how the net-effect of such an interaction can differ from a state of continuously fluctuating endogenous hormonal levels during the


manufactures will permit only pre-accredited installers, As a result generating these four roofer types restricting.

Just notify us about your requirements and gryphonaz.com we are going to promptly match you on the pre-screened, regional pros you could rely on to obtain the job finished. Uncover Pros For Mewithin range and line of fire, removing it from anywhere else. As long as that character is within line of fire of Zenyatta, all damage dealt to that character is increased by +1. Remove this token if Zenyatta does not have line of fire.

Pass into the Iris.: STOP! All damage dealt to Zenyatta until your next turn is ignored. This cannot be countered or ignored.

Orb of Harmony: Give Zenyatta a free action and place his Harmony token on a friendly character within range and line of fire, removing it from anywhere else. As long as that character is within line of fire of Zenyatta, at the beginning of your turn, heal that character 1 click. Remove this token if Zenyatta does not have line of fire. #018Real Name:Team:Range:Points:Keywords:Ignores


journey joyful, we begin by partnering with our customers from
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Makaan.com is part of elara technologies pte limited, singapore which also owns
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services provider. news corp, a global media, book publishing and digital real
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investors include saif partners, accel partners and RB
investments.Tracy Goodway

EES for Schools

Tracy Goodway

EES for Schools

Biography

Tracy Goodway has worked closely on the development of SE+ , collaboratively defining the research which underpins the maturity framework and co-authoring much of the current content. Tracy has worked within school improvement in a variety of roles for over 25 years in which she has applied her extensive experience of leadership and teaching. She has led and managed a variety of large scale projects and consultant adviser teams and was also seconded to the DfE as a School Standards Adviser.


estimator, [Section 3](#sec3){ref-type="sec"} is the Bayesian inference. Simulation study is in [Section 4](#sec4){ref-type="sec"} followed by results and discussion in [Section 5](#sec5){ref-type="sec"}. [Section 6](#sec6){ref-type="sec"} is real data analysis and then a conclusion is provided in [Section 7](#sec7){ref-type="sec"}.

2. Maximum Likelihood Estimation {#sec2}
================================

Let *t* ~1~,..., *t* ~*n*~ be the lifetimes from a random sample of size *n* where the probability density function (pdf) is represented by *f*(*t*, *α*, *β*), the cumulative distribution function (cdf) is *F*(*t*, *α*, *β*), and the survival function is *S*(*t*, *α*, *β*); given the two-parameter Weibull distribution we have, respectively, $$\begin{matrix}
{f\left( {t,\alpha,\beta} \right) = \frac{\beta}{\alpha}\left( \frac{t}{\alpha} \right)^{\beta - 1}\exp\left\lbrack {- \left( \frac{t}{\alpha} \right)^{\beta}} \right\rbrack,} \\
\end{matrix}$$ $$\begin{matrix}
{F\left( {t,\alpha,\beta} \right) = 1 - \exp\left\lbrack {- \left( \frac{t}{\alpha} \right)^{\beta}} \right\rbrack,} \\
\end{matrix}$$ $$\begin{matrix}
{S\left( {t,\alpha,\beta} \right) = \exp\left\lbrack {- \left( \frac{t}{\alpha} \right)^{\beta}}of the LINEX loss function is $$\begin{matrix}
{E_{\theta}\left\lbrack {L\left( \Delta \right)} \right\rbrack = e^{c\hat{\theta}}E_{\theta}e^{- c\theta} - c\left( \hat{\theta} - E_{\theta}\theta \right) - 1.} \\
\end{matrix}$$ The value of $\hat{\theta}$ that minimizes the above equation is $$\begin{matrix}
{{\hat{\theta}}_{\text{BL}} = - \frac{1}{c}\ln E_{\theta}\left( e^{- c\theta} \right)} \\
\end{matrix}$$ provided *E* ~*θ*~(·) exists and is finite.(3)Another useful asymmetric loss function is the general entropy (GELF) which is a generalization of the entropy loss and is given as $$\begin{matrix}
{L\left( {\hat{\theta} - \theta} \right) \propto \left( \frac{\hat{\theta}}{\theta} \right)^{k} - k\ln\left( \frac{\hat{\theta}}{\theta} \right) - 1.} \\
\end{matrix}$$ The Bayes estimator ${\hat{\theta}}_{\text{BG}}$ of *θ* under the general entropy loss is $$\begin{matrix}
{{\hat{\theta}}_{\text{BG}} = \left\lbrack {E_{\theta}\left( \theta^{- k} \right)} \right\rbrack^{- {1/k}},} \\
\end{matrix}$$ provided *E* ~*θ*~(·) exists and is finite.

It may be noted that ([10](#EEq10){ref-type="disp-formula"}) contains double integrals which cannot be solved analytically;


exponential loss followed by general entropy loss function. This is so because both loss functions take into consideration an overestimation and underestimation, even though they have different approaches. Again, we observe that both linear exponential and general entropy loss functions overestimate the scale and shape parameters of the Weibull distribution, that is, *c* = *k* \> 0.

In a practical perspective, the use of symmetric loss function is based on the assumption that the loss is the same in any direction; that is, it is simply the magnitude of the losses incurred. Therefore, if one is not interested in knowing whether the assumption made with regards to the duration or the mortality state of the patients being investigated gives a signal as to whether our conclusion is above orfollowed by general entropy loss function. Notwithstanding the fact that the Bayesian estimator gives narrower credible intervals as compared to the classical maximum likelihood estimator, there is still an advantage for using the Bayesian credible intervals over the classical confidence intervals. Briefly, a frequentist 95% confidence interval of, say, (2,4) means, with a large number of "repeated" new samples at a time, 95% of the calculated confidence intervals would include the true value of the parameter, this is in contrast to the Bayesian analogy of credible interval, which states that with a small sample "not repeatedly" contains the true parameter 95% at a time. In the Bayesian approach the parameter is observed as being random and sought for.

The values in bold indicate the smallest standard errors and narrower


values were found to be nonsignificantly higher post-RWT, and we attribute this lack of significance to individual differences in muscle mass, gait pattern, and walking speed. It has been reported that mild aerobic exercise uses fat as a fuel, and thus, aids in weight maintenance. In a study that compared heavy- and mild-intensity exercises, no postexercise difference in body composition was observed in the heavy-exercise group, but a significant difference was noted in the mild-exercise group, which suggests that mild-intensity exercise is more effective at reducing body fat levels. Furthermore, it was found that the cardiovascular systems of females who performed mild-exercise programs improved as much as those who performed jogging and cycling exercises[@r16], [@r17]^)^.

Physical activities and exercise consume energy and have a positive effect on health andthe central European Jewish baths Schmeis were used in place of birch twigs: long brushes made of rafia. After the first good sweat is induced, it is customary to cool off in the breeze outdoors or splash around in cold water or in a lake or river. In the winter, people may roll in the snow with no clothes on or dip in lakes where holes have been cut into the ice. Then the banya is re-entered and small amounts of water are splashed on the rocks. If too much water is used at once, the steam will be cool with a clammy feel. A small amount of water on sufficiently hot rocks will evaporate quickly, producing a steam consisting of small vapour particles. Waving the venik causes


bathhouses had special rooms for massage, gyms, and libraries. Wealthy citizens went to the bathhouse twice a day. Both private and public baths were distinguished by exceptional luxury – swimming pools were made of precious marble, silver and gold were used to decorate sinks. By the first century BC there were around 150 thermae in Rome. Steam rooms were heated in the same way as Russian banyas and Finnish saunas: the oven was placed in the corner, stones were laid on a bronze frame over red-hot charcoal. Rooms with wet and dry steam were also available. Hot air came through a pipe under the floor. The structure of thermae was complex: there were 5 rooms: a room for undressing and resting after bathing, a swimming pool for thep;
			return string.Compare (x.Id.Version, y.Id.Version, StringComparison.Ordinal);
		}

		static int CompareProfiles (string x, string y)
		{
			int xn, yn;
			if (TryParseProfileID (x, out xn)) {
				if (TryParseProfileID (y, out yn))
					return xn.CompareTo (yn);
				return 1;
			}
			if (TryParseProfileID (y, out yn))
				return -1;
			return string.Compare (x, y, StringComparison.Ordinal);
		}

		static bool TryParseProfileID (string profile, out int id)
		{
			if (profile != null && profile.StartsWith ("Profile", StringComparison.Ordinal))
				return int.TryParse (profile.Substring ("Profile".Length), out id);
			id = -1;
			return false;
		}

		static string GetDisplayName (SupportedFramework sfx)
		{
			if (!string.IsNullOrEmpty (sfx.MinimumVersionDisplayName))
				return sfx.DisplayName + " " + sfx.MinimumVersionDisplayName;
			else if (!string.IsNullOrEmpty (sfx.MonoSpecificVersionDisplayName))
				return sfx.DisplayName + " " + sfx.MonoSpecificVersionDisplayName;
			else
				return sfx.DisplayName;
		}

		static string GetShortName (SupportedFramework sfx)
		{
			switch (sfx.DisplayName) {
				case ".NET Framework":
					return "NET" + sfx.MinimumVersionDisplayName.Replace (".", "");
				case "Silverlight":
					return "SL" + sfx.MinimumVersionDisplayName;
				case "Xamarin.Android":
					return "Android";
				case ".NET for Windows Store apps":
					return "WinStore";
				case "Windows Phone":
					return "WP" + sfx.MinimumVersionDisplayName.Replace (".", "");
				case "Xbox 360":
					return "XBox";
				case "Xamarin.iOS":
					if (string.IsNullOrEmpty (sfx.MonoSpecificVersionDisplayName))
						return "iOS";
					else
						return "iOS/" + sfx.MonoSpecificVersion;
				default:
					return GetDisplayName (sfx);
			}
		}

		internal static string GetPclShortDisplayName (TargetFramework fx, bool


();

			infoImage = new ImageView (Xwt.Drawing.Image.FromResource (GetType ().Assembly, "warning-16.png"));
			warningImage = new ImageView (Xwt.Drawing.Image.FromResource (GetType ().Assembly, "error-16.png"));

			warningHBox = new HBox (false, 6);
			warningHBox.PackStart (infoImage, false, false, 0);
			warningHBox.PackStart (warningImage, false, false, 0);
			warningHBox.PackStart (warning, false, true, 0);

			alignment.Child = warningHBox;
			alignment.Show ();

			VBox.PackStart (alignment, false, true, 0);
		}

		void ClearWarnings ()
		{
			warning.LabelProp = string.Empty;
			warningHBox.Hide ();

			infoImage.Hide ();
			warningImage.Hide ();
		}

		void SetWarning (string message)
		{
			warning.LabelProp = message;
			infoImage.Hide ();
			warningImage.Show ();
			warningHBox.Show ();
		}

		void SetWarning (string message, params object[] args)
		{
			SetWarning (string.Format (message, args));
		}

		void AddWarning (string message, params object[] args)
		{
			AddWarning (string.Format (message, args));
		}

		void AddWarning (string message)
		{
			if (!string.IsNullOrEmpty (warning.LabelProp))
				warning.LabelProp += Environment.NewLine;
			warning.LabelProp += message;
			infoImage.Hide ();
			warningImage.Show ();
			warningHBox.Show ();
		}

		void AddInfo (string message, params object[] args)
		{
			AddInfo (string.Format (message, args));
		}

		void AddInfo (string message)
		{
			if (string.IsNullOrEmpty (warning.LabelProp)) {
				warningImage.Hide ();
				infoImage.Show ();
			} else {
				warning.LabelProp += Environment.NewLine;
			}
			warning.LabelProp += message;
			warningHBox.Show ();
		}

		void TargetFrameworkChanged (OptionCombo option)
		{
			if (disableEvents)
				return;

			try {
				disableEvents = true;
				TargetFrameworkChanged_internal (option);
			} finally {
				disableEvents = false;
			}
		}

		void TargetFrameworkChanged_internal (OptionCombo option)
		{
			ClearWarnings ();
			selectorCombo.Active = -1;

			// The currentlymeasurements, and particularly when testing using pulsed signals. The high inductance tends to resist fast changes in the current levels, and results in higher than desirable voltage and current levels.
What is desired, therefore, is a probe station that is suitable for performing high current and/or pulsed tests.
The foregoing and other objectives, features, and advantages of the invention will be more readily understood upon consideration of the following detailed description of the invention, taken in conjunction with the accompanying drawings.


antibodies: MARCH1 (Abcam), CLEC10A (Abnova), SOCS5 (GeneTex), CLEC4A (GeneTex) and tubulin (SIGMA-ALDRICH).

Chromatin immunoprecipitation (ChIP) {#SEC2-4}
------------------------------------

ChIP experiments were performed as described ([@B24]) using antibodies against H4Ac (Upstate Biotechnology/Millipore), H3Ac (Upstate Biotechnology/Millipore), H3K4trim (Abcam), RNA pol II (Abcam) and PU-1 (Santa Cruz). Results were quantified by real-time PCR using the iCycler iQ Real-Time PCR Detection System (Biorad) and a Sybr-Green-based kit for quantitative PCR (iQ Supermix Biorad). Primer sequences are available upon request.

ChIP-chip experiments {#SEC2-5}
---------------------

Three biological replicates of H4Ac-ChIP samples were prepared from immature Mo-DCs and Mo-DCs stimulated for 1 h with LPS, and verified by quantitative PCR to assess LPS-induced H4-deacetylation at the *CIITA* locus. DNA was purified, amplified by LPMCR as described ([@B24]) and sent to Roche-NimbleGen for probe preparation and hybridization to HG18 arrays carrying promoter regions0.5% sodium dodecyl sulphate (SDS). Nascent RNA was purified by three extractions with hot phenol (saturated with 50 mM NaAc pH5, 50mM NaCl) and precipitated with 0.15 M NaCl and ethanol. RNA was resuspended in 50 μl 10 mM Tris-HCL (pH 7.6) and treated with DNaseI for 15 min at 37°C in 10 mM MgCl~2~, 1 mM DTT. DNase activity was stopped by adding 50 mM EDTA, 1.5 M NaAc, 1% SDS and RNA was purified by phenol-chloroform extraction and ethanol precipitation. Nascent RNA samples were depleted of ribosomal RNA (rRNA) using the Ribominus kit (Invitrogen). Nascent RNA samples corresponding to three independent experiments were subjected to quality controls by qRT-PCR. DNA contamination was excluded by omitting reverse transcriptase. Maturation was assessed by measuring IL12B, IL1B and TNF


([@B27]).

ChIP sequencing {#SEC2-8}
---------------

10 ng of immunoprecipitated-DNA or chromatin-input-DNA were used to prepare sequencing libraries using Illumina specifications. 50-nucleotide single-end reads were generated using Illumina technology. Reads were aligned to the reference human genome GRCh37.71 using Bowtie version 0.12.7 (<http://bowtie-bio.sourceforge.net/index.shtml>). Only uniquely mapped reads were considered for further analysis. Peaks were called using MACS software version 2.0.10.20130520 (<http://liulab.dfci.harvard.edu/MACS/>). Input-DNA was used as background control. Peaks were considered significant if their *P*-values were \<10^−5^ and if present (overlapping by \>1 nt) in two biological repeats.

TFBS enrichment {#SEC2-9}
---------------

Pscan was used to identify potential TF-binding-sites (TFBSs) (JASPAR database) that are overrepresented between nucleotides −450 and +50 relative to the TSS (<http://159.149.160.51/pscan/>). TFBSs with *P*-values \<10^−3^ were considered to be significantly overrepresented.

Gene ontology {#SEC2-10}
-------------

Gene ontology analyses were performed at <http://david.abcc.ncifcrf.gov/> and <http://cbl-gorilla.cs.technion.ac.il/>.

RESULTS {#SEC3}
=======

Silencingare represented as green, red and black dots, respectively. (**C**) The pie chart shows the percentage of deacetylated genes expressed more than 1 RPKM in immature Mo-DCs. The dot plot shows 1 h-LPS-induced changes in nascent-transcript (red dots) and mRNA (black dots) expression for deacetylated genes; genes are ordered with respect to their change in nascent-transcript expression; positions of representative genes are highlighted. (**D**) TFBS enrichment analyses were performed for promoters of genes that are induced (\>2, 3 or 5-fold), deacetylated and silenced (\>2, 3 or 5-fold), or exhibit no change (nc) in expression in Mo-DCs after 1 h of LPS treatment. TFBSs were defined according to JASPAR. The heat map shows the relative enrichment (*z*-score) of TFBSs that are significantly over-represented (*P*-value \< 10^−3^). (**E**) The graphs


next year.

“Banning assault weapons was always a long shot,” said Adam Winkler, a UCLA law professor and author of “Gunfight: The Battle Over the Right to Bear Arms in America.” “Gun control advocates will be disappointed, but dropping Sen. Feinstein’s proposal may make it easier for the other proposals, like background checks, to gain passage.”

Still, Reid’s decision was a personal blow to Feinstein. She has regarded the 1994 law as one of her signature achievements. The pen President Clinton used to sign the measure hangs prominently in her office.

“She’s faced tough odds before,” said Mark Kadesh, a former Feinstein chief of staff. “She fights the fight because she’s always fought the fight.... She’s surprised people in the past. Even if unsuccessful, sometimes you have to fight the fightbit of my childhood is gone.”

The Country Kickstart Show was just the first of a series of concerts during the CMA Music Festival taking place through Sunday (June 13). Later in the day, several major country acts signed autographs at Fan Fair — now the name of the area at the Nashville Convention Center. Among them: Montgomery Gentry, Lonestar, Blake Shelton, Mark Wills, John Berry, Pam Tillis and Charlie Daniels.


list represents our best definition of the canonical RPG—games that likely emphasize story; that let you inhabit a customizable character through skill points, inventory, and dialogue decisions; that include complex, controllable relationships with companions or non-playable characters. Drawing these kinds of lines helps us provide a better service to you, we hope—though we've made some exceptions where we think it's worth it.

The Witcher 3: Wild Hunt

Read more Need your RPGs to look their best? Here are the best gaming PCs right now.

Release date: 2015 | Developer: CD Projekt Red | Humble Store, Steam

Many of the best RPGs focus on tales of lone, wandering adventurers, but few if any pull it off it with such artistry as The Witcher 3. That artistry is most apparent in the setting itself,entails. Your predetermined protagonist is a detective who wakes up after an amnesia-inducing bender without a badge, gun, or a name. As the detective, you'll attempt to solve a murder in the retro city of Revachol while also solving the mystery of your past and identity.

There is no combat, at least not in the way you'd expect of a classically-inspired RPG. Instead, the majority of Disco Elysium takes place in conversation either with characters you need to interview about the murder or with your own mind. Each of your skills in Disco Elysium are parts of your personality with opinions on what to say and do during your investigation. Empathy will helpfully clue you in to the feelings of people you talk to so you can better understand


cousin, Grim Dawn lets you pick two classes and share your upgrade points between two skill trees. This hybrid progression system creates plenty of scope for theorycrafting, and the skills are exciting to use—an essential prerequisite for games that rely so heavily on combat encounters.

The story isn’t bad either, for an ARPG. Don’t expect twisting plots and decisions with consequences—this is very much a game about single-handedly destroying armies—but there is a neat faction reputation system that spawns harder mobs and villainous nemesis heroes as you become more hated by the criminals, cults and monsters that rule the wilderness. The local demons and warlords that terrorize each portion of the world are well sketched out in the scrolling text NPC dialogue and found journals. Ultimately, it’s about theduring each dungeon run. A few hours into the campaign, your precious heroes become deeply flawed tools that you either need to learn how to work with, or use until they break, and replace like disposable batteries.

With Lovecraft's hell as your workplace, Darkest Dungeon is about learning how to become a brutal and effective middle manager. Your heroes will be slaughtered by fishmen, cultists, demons, and foul pigmen as you push through decaying halls, but more will return to camp with tortured minds or other maladies. Do you spend piles of gold to care for them, or put those resources toward your ultimate goal?

Darkest Dungeon is a brilliant cohesion of art, sound, writing, and design. The colorful, hand-drawn horrors pop from the screen, showing their influence but never


all this to the already-tremendous feeling of wiping out hordes of baddies with a well-timed ability change, RoS is the defining action RPG for us. It’s a game we’ll be playing for a long, long time.

Arcanum: Of Steamworks and Magick Obscura

Release date: 2001 |Developer: Troika Games | GOG

Arcanum: Of Steamworks and Magick Obscura was astoundingly buggy when it came out, and many of its battles were as laughably imbalanced as its title. Patches and mods have alleviated some of that pain over the years, but even then they weren't powerful enough to hide what a great mix of fantasy and steampunkery thrived under its surface. As we said in our enthusiastic review in 2001, "If you can’t find something to love about this game, dump your computer inthe garbage right now."

That assessment holds up. Arcanum was dark 'n' gritty before some such tendencies became all the rage, and its character creator allowed players to create everything from gnome gamblers who brandish self-explanatory Tesla-guns to outcast orcs lugging along rusty maces. Toss in non-linear progression and multiple solutions for quests, and you've got a winner that holds up 14 years later.

Fallout: New Vegas

Release date: 2010 | Developer: Obsidian | Humble Store, Steam (Ultimate Edition)

While Fallout 3 was successful, it was a different beast entirely from Interplay’s classics. Obsidian’s take on the franchise moves the action back to the West Coast, and reintroduces elements such as reputation and faction power struggles. Obsidian expands on nearly every aspect of Bethesda’s take, making the game less about good or


character’s build is a process deeper than most D&D-themed RPGs, but it’s ultimately just as rewarding.

So is discovering the rich lore of Lordran, which is told through cryptic conversations and subtle environmental clues. The depth of Dark Souls' world carries over into exploration, too. Everything is connected brilliantly, and secrets and shortcuts—including massive hidden areas and features—await the most dedicated adventurers. Dark Souls' summoning system is also unlike anything else in RPGs, but you can unplug and beat the whole game solo, or learn to love being invaded and fighting off another player. Don’t let the rumored difficulty keep you away from one of our favorite RPGs.

Fallout 2

Release date: 1998 | Developer: Black Isle Studios | GOG

The original Fallout was a huge success for Interplay, but it’s notas big of a world as you’d expect. The sequel expands that world considerably, and adds more moral ambiguity to a game where right and wrong are already hard to tell apart. Playing as a tribal villager instead of a native Vault dweller gives you a different world perspective—you’re not as naive to the world and its dangers, which makes it all the darker when you start twisting people’s expectations and motivations.

The search for the Garden of Eden Creation Kit (GECK) fits the warped 1950s feel of the wasteland more than the macguffin of a water chip in the first game. And it’s nice to not have such a time limit hanging over your head: you can take your time and get to know the people of the


I'm concerned." "I have no time for women who try to conceal their ages." "It's all very well to talk if you've nothing to conceal." " What do you say, Hilton?" " Perhaps." "Doesn't seem to matter." "You're all right, anyway." "You needn't worry." "It's the stringy kind like me that wears badly." "It's time for..." "It's time for exercise." "Let's go out before it starts raining." "That was a close shave." "I think it's silly the way we officers aren't allowed to smoke and the prisoner is." "Of course." "'Ere." "Have one." "And since to look at things in bloom, 50 springs are little room," "About the woodlands I will go," "To see the cherry hung with snow." "Keep moving, Hilton, or you'll be cold." "You'll bealways." "Jim used to meet me most evenings after that." "I remember the first time he took me back to where he lived." "Come on, in here." "I told you it's quite a way from the bus stop." "We should have waited for a cab." "You're soaked." "Doesn't matter." "What a nice room you've got." "I suppose not too bad." "Been in plenty worse." "Still, the view isn't exactly Buckingham Palace." "Come on." "These will warm us up." "Come on." "Knock it back." "Who's that woman downstairs?" "She gave me rather a peculiar look." "You mean my landlady, Mrs Thomas." "Doesn't she approve of female visitors?" "No, not on principle, but I flatter myself I'm her favourite lodger." "Sounds as though you have hundreds of girlfriends." "Oh, thousands."


"You know, sometimes there's such a crush on the staircase, can't get up or down." "You know something, I feel very funny." "Slightly delirious." "If you don't get out of those wet clothes, that's what you will be." "Have a hot bath." "That's one thing about this dump, the water's always boiling." "Well, there it is." " I'll go and see about some food." " OK." "How do I look?" "Wonderful." "You'd better get by the fire, you'll catch cold." "You sound as though you've caught one already." "Don't worry about me." "Nobody would care if I caught double pneumonia." "What's the matter with you?" "Why do you always sound so bitter?" "It's nothing." "You know, you've never really told me all about yourself." "What, the story ofRoy wanted me to go dancing with him." " Why didn't you?" " What do you think I am?" "A nightclub queen?" "I have to get up early and do a full day's work tomorrow." "Look, some other time." "I'm gonna be late." " Late for what?" " I told you." "I've got another engagement tonight." " You didn't tell me." " Sure I did." "At Perry's Club." " Can I come too?" " Thought you weren't a nightclub queen." "Anyway, the boss wouldn't like it." "Shall I see you tomorrow evening?" " No, I'm going to the dogs with Ally." " Again?" "Why not?" "I need the money." "Did quite well last time." "I've got a new system." "Then when?" " Friday, I guess." " Jim." "If


Columbus Weddings Fashion Week: White of Dublin

Monday

Feb 12, 2018 at 8:00 AM

Presenting looks from the Runway Show at the 2018 Columbus Weddings Show last month.

Emma Frankart Henterly

Guests at the Columbus Weddings Show last month were treated to a stellar Runway Show showcasing gowns from some of the area’s top boutiques (plus menswear from Men’s Wearhouse). In honor of New York Fashion Week, which began last Thursday, we’re featuring one shop from our own Runway Show each day this week. Kicking things off today is White of Dublin, which brought some fabulous looks from Ian Stuart, Galia Lahav, Sassi Holford, Pronovias and Martina Liana. Click through the full lineup in the slideshow above, and be sure to check back every day this week for even more stunning looks!

Hair and35,000 Muslim volunteers from around the world came to fight in Afghanistan. Thousands more Muslims attended "frontier schools teeming with former and future fighters." From there, Azzam was able to organize resistance directly on the Afghan frontier. Peshawar is only 15 km east of the historic Khyber Pass, through the Safed Koh mountains, connected to the southeastern edge of the Hindu Kush range. This route became the major avenue for inserting foreign fighters and material support into eastern Afghanistan for the resistance against the Soviets.

After Osama bin Laden graduated from the university in Jeddah in 1981, he also lived for a time in Peshawar; Azzam convinced bin Laden to help personally finance the training of recruits. Some have suggested that Mohammed Atef was responsible for convincing Azzam to abandon


Mapping soil gas radon concentration: a comparative study of geostatistical methods.
Understanding soil gas radon spatial variations can allow the constructor of a new house to prevent radon gas flowing from the ground. Indoor radon concentration distribution depends on many parameters and it is difficult to use its spatial variation to assess radon potential. Many scientists use to measure outdoor soil gas radon concentrations to assess the radon potential. Geostatistical methods provide us a valuable tool to study spatial structure of radon concentration and mapping. To explore the structure of soil gas radon concentration within an area in south Italy and choice a kriging algorithm, we compared the prediction performances of four different kriging algorithms: ordinary kriging, lognormal kriging, ordinary multi-Gaussian kriging, and ordinary indicator cokriging. Their results were 18
     [9,]    9   19
    [10,]   10   20

    [[2]]
          [,1] [,2]
     [1,]   21   31
     [2,]   22   32
     [3,]   23   33
     [4,]   24   34
     [5,]   25   35
     [6,]   26   36
     [7,]   27   37
     [8,]   28   38


   [9,]   29   39
    [10,]   30   40

I want to do another list of two matrices of order 10 by 4(length of t). I can do it for individual matrix. For the first matrix
n.iter=nrow(y_list[[1]])
t.i=c(01,2,3,4)
y_list.1=matrix(NA, nrow = n.iter, ncol=length(t.i))
for( iter in 1:n.iter){
  for (t in 1:length(t.i)){
    y_list.1[iter,t]=y_list[[1]][iter,1]+y_list[[1]][iter,2]*t.i[t]
  }
}
y_list.1

> y_list.1
      [,1] [,2] [,3] [,4]
 [1,]   12   23   34   45
 [2,]   14   26   38   50
 [3,]   16   29   42   55
 [4,]   18   32   46   60
 [5,]NSW,) and now I’ve heard it twice on that station! Someone rang up and requsted it in the all- aussie hour. That’s pretty good for a station who usually only plays Pussycat Dolls and radio-friendly MOR rock.
P.S RHCP rock!

I’m so postmodern i bought a teddy bear at a 2nd hand clothes shop, cut off its ears and reshaped it to look like a duck, stuffed it with baked beans and sent it floating in the ocean with a note in its beak reading “im so postmodern”.

i wil admit to downloading all my music off the net. i havent bought a cd in years, firstly because all the songs i wanted where by artists that can afford it, or the rest of the cd was so shit that humainly


side of grapes far more intriguing. eg; are you REALLY looking at the doilie, or is the doilie LOOKING AT YOU? Wooooo…
That quote on colored balls seriously should be put in a song, though.
P.S- I didn’t think stairway to heaven really had a satanic message when played backwards, but spicks and specks really opened my eyes… and just proves that some people have way too much time on their hands.

I had to take the acoustic megamix down for a little while due to legal shananagins. (Ben Lee took a swing….he didn’t try and punch me he just stole my favourite swingset out of vengeance) It will be up again soon, hopefully. In the meantime, check out the Postmodern lyric writing concern in StruthBeTold section! Inquisitivity.

Bwahaha! I managed toin a baseball stadium look like a bunch of miniature figurines. EasyFocus also enables the user to freehand the focus area, for more precision. You can also use the Photo Enhance tool to make images look more vibrant.

...great for pushing you to get things done, hard to ignore if you're a procrastinator

No, no, no, and, I must add, no! I'm pretty serious about the art of procrastination. Give me easy to ignore and dismiss, or the deal is off. I've quite a bit more to say about this, and may return to this thread at a later time. [Clickety-click. There, I've scheduled it.]

as someone who listens to tens of hours of podcasts every week, the best is unquestionably BeyondPod

As someone who listens to a large number of podcasts.


is the source of these app recommendations exactly? How is an app chosen for these lists? Are these apps that Ars staff are using and personally want to recommend, or are these apps which have perhaps asked to be covered or evaluated by Ars?

To put it another way: Is this more equivalent to Ars reviewing a new smartphone, or is this more equivalent to "The Dealmaster"?

The source of these app recommendations are: me! I use every app for at least a week before I even consider writing about it. I find apps by checking out whatever the Google Play Store is showcasing, finding out what other Android users are raving about, or asking my friends and colleagues. If you have a specific recommendation you are always welcome tomay subsequently affect their food preference \[[@B9-nutrients-04-00554]\]. For instance, products perceived as fat, high in proteins, with a savory taste are expected to have a higher level of satiety compared to sweet products. Previous reports described that stress generally produces differential effects on eating depending on the type of subject. For instance, restrained and emotional eaters tend to overeat in response to stress, whereas the intake of unrestrained and non-emotional eaters remains constant or may decrease \[[@B3-nutrients-04-00554]\]. Moreover, stress is often associated with increased consumption of high fat and highly palatable foods \[[@B4-nutrients-04-00554],[@B10-nutrients-04-00554]\]. Various studies have demonstrated that individuals in a negative mood state may eat in an effort to provide comfort or distraction from negative emotions \[[@B6-nutrients-04-00554],[@B11-nutrients-04-00554],[@B12-nutrients-04-00554]\]. For instance, the intake of chocolate was examined as a


to abstain from chocolate and chocolate-containing products during run-in was monitored upon inquiry on day 01 of the study. This allowed for the greatest possible effects to be found for the consumption of the two chocolate products on the first test day, and thus for determining a baseline for their effects. During a period of two consecutive weeks, participants were asked to consume the test products on a twice-daily basis at home and/or at work. Subjects were asked to report deviations from consumption of the study substances and from dietary restrictions. During this period, subjects kept a diary with entries recording stressful events that occurred during the study and responses to a shortened version of the emotion questionnaire. From the daily records, the number of stressful events wasadministered between T30 and T60 after consuming the snack. The results on cognitive performance are not reported in the present work, since no significant effects and trends were observed.

2.5. Analysis
-------------

Structural equation modeling (SEM), a statistical analysis for testing and estimating causal relationships using a combination of statistical data and qualitative causal assumptions, was applied for data analysis. The scale reliability was assessed for each of the three scales (anxiety, energy and emotional states) according to a previously published method \[[@B27-nutrients-04-00554]\]. Unreliable items or items with little discriminative value were removed from the scales and not used for further analyses using a three step approach. First, the variance of the responses was examined for response biases (e.g., ceiling effects), by subjectively viewing the distributions and removing items in which


only one or two response categories were used or in which the distribution was particularly skewed. Second, factor analysis (FA) of the remaining items was applied separately for the three scales (anxiety, energy and emotional states). Each analysis resulted in one usable and interpretable factor summarizing a sub-set of items from the total scale. Third, the coefficient of reliability Cronbach's α was generated for each sub-scale. The state anxiety scale had an α \< 0.85, the energy scale had an α \< 0.82 and the emotion scale had an α \< 0.81. The high values of Cronbach's α indicate that the new scales are highly reliable. Therefore, further analysis was only performed only on the items remaining after FA.

These items were averaged separately for anxiety, energy and emotionaleffect is the result of changes in the levels of perceived energy for the high anxiety trait participants as well as for the low anxiety trait participants over time. The mean (±SEM) for the perceived energy score per food condition at different time points for high and low anxiety trait participants are shown in [Figure 1](#nutrients-04-00554-f001){ref-type="fig"}. Statistical analysis found that only the intake of the milk chocolate snack resulted in an improvement of energy states in high anxiety trait individuals, 60 min after consumption compared to baseline (*t* = 0/*t* = 10: *p* = 0.490; *t* = 0/*t* = 60: *p* = 0.033; *t* = 10/*t* = 60: *p* = 0.150). Low anxiety trait participants receiving the milk chocolate snack felt that they had lower energy levels 60


anxiety in free-living subjects, it was not feasible to correct for the total energy intake of the subjects, menstrual cycle in the women or for eating behavior, which are additional confounding factors. However, the study provided novel insights into the consumer perception of different snack products on postprandial wellness, which can be followed-up in future studies.

5. Conclusions
==============

The observations from this study demonstrate how snacks differing in sensory properties and presentation can influence the postprandial experience of consumers with low or high anxiety trait over a period of two weeks. The milk chocolate snack resulted in the decrease of anxiety in high anxiety trait subjects, whereas low anxiety trait participants could perceive benefits on energetic state with cheese and crackers. The mood effects were not altered with repeated exposure,Q:

How should I dispose of Sulfuric Acid?

I have about 30 ml of leftover Sulfuric acid. There is a similar thread on this board suggesting ways to dispose of it. They involve adding baking soda after adding the sulfuric acid to water. However, the MSDS sheet for sulfuric acid contains the following statement which scares me:
"A violent exothermic reaction occurs with water."
Any suggestions please.

A:

As my high school chemistry instructor made us learn:
Do as you oughta - add acid to water.
If you add water to acid, the reaction dynamics work out badly and you get the MSDS warning - the water boils, this spits acid solution all over, and is dangerous.
If you add acid to water, the reaction dynamics work in a more favorable fashion, and nothing exciting happens as


In the combustion of fossil fuels, which is carried out with the aim of energy recovery, and in the incineration of refuse, sewage sludge and industrial waste, which is carried out with the aim of waste disposal and energy recovery, flue gases are formed that are contaminated by heavy metals, heavy-metal compounds, and other pollutants (e.g., ash, SO2, SO3, and the like). The contaminants are present in the flue gas in different amounts depending on the particular combustion process, and the concentration of the contaminants undergoing certain variations during each combustion process. For example, the different and varying composition of refuse, industrial waste and sewage sludge means that the flue gases formed on combustion of this waste are contaminated by different amounts of environmentally polluting substances present indisposed of in pits and/or waste lagoons. The approximately 1.05 billion tons of coal burned each year in the United States contain significant amounts of toxic wastes. On top of emitting 1.9 billion tons of carbon dioxide each year, coal-fired power plants in the United States also create 120 million tons of waste each year. That means each of the nation's ˜500 coal-fired power plants produces an average 240,000 tons of waste each year. A power plant that operates for 40 years will leave behind ˜9.6 million tons of waste.
Many of the heavy metals that are released as products of combustion from power plant, incinerators, and the like are environmentally and biologically toxic elements, such as lead, mercury, nickel, tin, cadmium, antimony, and arsenic. Waste that is stored


the model is overfitting from the beginning!

A:

There could be 2 reasons. First you overfit on the training data. This can be validated by using the validation score as a comparison metric to the test data. If so you can use standard techniques to combat overfitting, like weight decay and dropout.
The second one is that your data is too different to be learned like this. This is harder to solve. You should first look at the value spread of both images. Are they both normalized. Matplotlib normalizes automatically for plotted images. If this still does not work you might want to look into augmentation to make your training data more similar to the test data. Here I can not tell you what to use, without seeing both thecomment

Police broke up an underage drinking party over the weekend and charged a 19-year-old at his home in Wilton.

Officers responded to the residence at 12 Powder Hill Road on Saturday, June 22 at midnight, according to Wilton Police.

When they arrived at the home, the offers found a number of underage people who allegedly appeared to be under the influence of alcohol, police said.

An investigation revealed Spencer Thors, 19, was reportedly found to be the one throwing the party and who provided the alcohol, said police.

He was charged with permitting minors to possess alcohol and possession of alcohol by a minor, given a misdemeanor summons, then released on a promise to appear in Norwalk court on Tuesday, July 2, according to the Wilton Police Department.


produced detectable AI-2-like activity. The AI-2-like activity was evident mainly associated with the Leuconostoc sp. B 233 strain, which was the dominant isolate recovered from storage at 10 and 15°C and at the initial and middle stages of storage at chill temperatures (0 and 5°C). The tested CFME samples displayed low AI-2-like activity and inhibited AI-2 activity regardless of the indigenous bacterial populations. The LAB isolated during meat spoilage exhibited AI-2-like activity, whereas the LAB strains retrieved depended on storage time and temperature. The production of AI-2-like molecules may affect the dominance of different bacterial strains during storage. The results provide a basis for further research concerning the effect of storage temperature on the expression of genes encoding AI-2 activity and on the diversity of the ephemeral bacterialadded to the cells and the plates were incubated overnight. The supernatants were removed and the cells were incubated in new medium for 72 h at 37°C.

Detection of pseudo-particles {#sec011}
-----------------------------

The expression of LacZ in cultured cells was evaluated with X-Gal Staining as described previously \[[@pone.0134141.ref020]\]. First, the cells were washed with cold PBS and fixed with glutaraldehyde for 10 min at room temperature. Then, the cells were incubated with X-Gal solution at 37°C for 1--16 hours, depending on staining intensity checked every hour under a light microscope. The infectious titers were expressed as transducing units (TU) per milliliter.

Inhibition of HCVpp entry {#sec012}
-------------------------

Huh7.5, PHH and HLMF cells were pre-incubated with 10 μg/ml anti-CD81 or irrelevant IgG control mAb. After 1 hour, HCV-H77pp, HCVpp-JFH1, VSV-Gpp, or No-envpp was added and


in HLMF {#sec025}
---------------------------------------

CD81 and LDLR expression was evaluated by RT-PCR, flow cytometry and immunofluorescence, and expression of the newly identified HCV co-receptors CLDN-1, OCLN and SR-BI using RT-PCR, immunofluorescence and Western blot. The mRNAs of CD81, LDLR, CLDN-1, OCLN and SR-BI, evaluated by RT-PCR, were expressed in HLMF. The results obtained in cells at passage 2 are shown in comparison with Huh7.5 cells and PHH, used as positive controls and HepG2 and T98G cells, as negative control ([Fig 2A](#pone.0134141.g002){ref-type="fig"}). Flow cytometry was also used at passage 2 and 3 to detect CD81 and LDLR. We observed that 95% of HLMF were CD81-positive compared with 98% of Huh7.5, 65% of PHH and 0.2% of HepG2, and that 75% of HLMF were LDLR-positive compared with 70%, 50% and 69% ofand 1a) were used to infect HLMF, Huh7.5 and PHH. The cells infected with HCVpp were subjected to an X-gal staining procedure at 72h after infection. As shown in [Fig 3A and 3B](#pone.0134141.g003){ref-type="fig"}, HCVpp from genotypes 1a and 2a readily infected Huh7.5 cells. PHH and HLMF were permissive for HCVpp entry at a lower level compared to Huh7.5. The positive control VSV-G infected easily Huh7.5 and HLMF but lowly PHH ([Fig 3A and 3B](#pone.0134141.g003){ref-type="fig"}). The pseudoparticles lacking glycoproteins were used as a negative control and did not infect the different cells used in this study. These results demonstrated that HCVpp could infect HLMF.

![Permissiveness of HLMF to HCVpp.\
Huh7.5, PHH and HLMF were infected with HCVpp (JFH-1a or H77-a), VSVGpp or CTRL-PUC (pUC19 no envelops). **(A)** The Huh7.5, PHH and


culture (P0) and at P1 ([Fig 6C](#pone.0134141.g006){ref-type="fig"}).

Discussion {#sec033}
==========

The mechanisms of hepatic fibrogenesis caused by HCV infection are not fully understood. HCV-replicating hepatocytes synthesize increased amounts of TGF-ß, which induces a fibrogenic response in liver myofibroblasts \[[@pone.0134141.ref006]\]. Bataller *et al*. reported that HCV core protein, and the nonstructural proteins NS3 and NS5, which were transduced into hepatic stellate cells by adenoviral vectors, exerted direct profibrogenic effects \[[@pone.0134141.ref017]\]. It has also been reported that a direct interaction occurs between the HCV envelope glycoprotein E2 and CD81 in human hepatic stellate cells and induces an up-regulation of MMP-2 expression \[[@pone.0134141.ref029]\].

JFH1-HCVcc has already been shown to replicate in cells other than hepatocytes. In particular, based on the detection of HCV proteins and of positive and negative strands of HCV RNA, it haspain (IIP) (VAS scale in mm). Blood pressure, and pulse were measured. Ninety patients, divided into three equal groups, were enrolled for the study. Ropivacaine gained statistically significant (p < 0.05) variables: QAS of 1.77 ± 0.68 and IIP was 18.90 ± 6.11 mm (p < 0.05). The SLA of the achieved local anesthesia was 96.6%, 93.3% and, 86.6% for ropivacaine, lidocaine with epinephrine 1:100000, and bupivacaine groups, respectively. OT was 151.50 ± 80.93, 168.27 ± 79.73, and 89.80 ± 27.91 sec, for groups I, II and III, respectively. The DA for ropivacaine was 412.17 ± 110.04 min, while the one for bupivacaine and lidocaine with epinephrine 1:100000 was 376.30 ± 98.51 min., and 216.13 ± 47.69 min., respectively. Hemodynamic parameters were insignificant to cause side effects. 0.75%


guidelines for that require that you disclose your affiliation with the resource in the answer. So do not write

These snippets from that website - explained there - will help you with…

but rather write

These snippets from my website - explained there - will help you with…

and everything will be OK.

Q:

foreach looping in multidimension array in php

Here is my PHP code:
 $marks = array(
    'Mohammad' => array('Phisics' => 50, 'Math' => 80),
    'Arif'     => array('Phisics' => 55, 'Math' => 95),

);
Now I want to get the Mohammad and Arif's marks with subject using foreach loop.

A:

You can use a nested foreach loop:
foreach ($marks as $name => $subjects) {
    foreach ($subjects as $subjectName => $subjectMark) {
        echo "${name}'s mark for ${subjectName} is ${subjectMark}.";
    }
}


bookmark webpage list and will be checking back soon. Please check out my website
too and let me know your opinion.

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It’s simple, yet effective. A lot of times it’s very
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I must say you have done a great job with this. Additionally,
the blog loads very quick for me on Opera.
Excellent Blog!   <?php echo __("Mark all as read") ?>

        <col width="5%" />
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= w - -41. Is u a prime number?
True
Suppose -4*v = -91 - 1. Let b(r) = -48 + 30 + 36*r + v. Is b(4) prime?
True
Let b(h) = 31*h**2 + 35*h - 7. Is b(15) a composite number?
True
Let b be (-47)/(-5)*(-4 + -1) - -1. Suppose 4*a = -2*h - 23 + 79, 0 = 5*a - 3*h - 92. Let f = a - b. Is f composite?
True
Let k(m) = 2*m**3 - 11*m**2 - 30*m + 21. Is k(14) prime?
False
Suppose 0 = -12*b + 16*b - 10444. Suppose -b = -5*p - 2*k, 2*p = 5*k + 301 + 726. Is p prime?
True
Let b = -2 - -4. Let c(f) = 25*f + 13*f - 17*f + 27*f - 1. Is c(b) prime?
False
Let m(v) = -2*v**3- 6. Is c(-8) a prime number?
True
Suppose -w + 26 = 5*l, 23 = 3*l + l + 3*w. Suppose -d = -t - 0*d, 3*t - l*d - 6 = 0. Is -1 + 3 + (462 - t) composite?
False
Let k be 70 - ((-3 - -4) + -3). Suppose 5*x + k = 1537. Is x a prime number?
True
Let b(j) = j**3 + 14*j**2 + 11*j + 1. Let k = -67 - -55. Is b(k) a composite number?
False
Let w be (2/(-4))/(11/44). Let r be 3/(-5) + 1224/(-10). Let j = w - r. Is j a composite number?
True
Let h(c) = 11*c**3 + 13*c**2 + c + 5. Let j(f) = 10*f**3 + 12*f**2 + f + 4. Let g(p) = -5*h(p) + 6*j(p). Is g(6)


CSE;  (2) Qantel's fraudulent representations induced CSE to enter into the original distributorship contract of April 16, 1976, or a subsequent extension thereof by a letter agreement dated August 1, 1977;  (3) CSE sustained the same compensatory damages under each theory of liability in the amount of $2,336,742 ($1,129,842 actual losses and $1,206,900 lost profits);  and (4) punitive damages of $15,000,000 should be awarded against Qantel for fraud.2

6
After the jury returned its verdict, Judge Keeton decided the choice-of-law issues upon which he had reserved ruling prior to submitting the case to the jury.  After further briefing and oral argument, he filed a comprehensive opinion, in which he concluded that Massachusetts, and not California, law governed both the fraud claim for punitive damages and the333 U.S. 364, 396, 68 S.Ct. 525, 542, 92 L.Ed. 746 (1948);  SEC v. MacDonald, 725 F.2d 9, 11 (1st Cir.1984);  Marshall v. Commonwealth Aquarium, 611 F.2d 1, 2 (1st Cir.1979).  Similarly, the standard for our review of the jury's verdict on the fraud claim is well settled.  We must "review the evidence and the inferences to be drawn therefrom in the light most favorable to appellee," and will vacate the verdict "only upon a determination that the evidence could lead reasonable men to but one conclusion, a determination made without evaluating the credibility of witnesses or the weight of the evidence at trial."   Hubbard v. Faros Fisheries, Inc., 626 F.2d 196, 199-200 (1st Cir.1980);  see also Coleman v. DeMinico, 730


F.2d at 771-72 (3d Cir.1975);  Brown & Root, Inc. v. Big Rock Corp., 383 F.2d 662, 666-67 (5th Cir.1967);  11 C. Wright & A. Miller, Federal Practice & Procedure Sec. 2809 at 62-64 (1973);  see also American Universal Insurance Co. v. Falzone, 644 F.2d 65, 67 (1st Cir.1981).

35
Finally, we will not disturb the district court's conclusion that this is not such an exceptional case that a new trial is required to prevent a miscarriage of justice despite lack of objection at trial.  See Fed.R.Civ.P. 61;  Nimrod v. Sylvester, 369 F.2d 870, 873 (1st Cir.1966);  Rojas v. Richardson, 713 F.2d 116, 118 (5th Cir.1983).   Cf. Schleunes v. American Casualty Co., 528 F.2d 634, 638 (5th Cir.1976);  Edwards v. Sears, Roebuckjury also found against Qantel on its counterclaim for payment for goods delivered.  The district court subsequently granted Qantel's motion for judgment n.o.v. and awarded $35,153.30 on the counterclaim.  CSE has not appealed this ruling

3
 The computer itself is the "hardware";  the programming necessary to run it is the "software";  together the hardware and software form the "computer system."

4
 Software packages generally require some modification for a particular user.  A "turnkey" software system is one that is easily adapted for various uses, requiring a minimum amount of reprogramming to be modified for a particular user.  It can be used almost straight "off the shelf."

5
 Between 1976 and 1980, when a turnkey version of SOLUTIONS was finally perfected, the number of programs in


challenge to Judge Keeton's award of double damages on the chapter 93A claim is limited to his interpretation of the language "willful or knowing violation" in section 11.  In this appeal, Qantel does not contest Judge Keeton's finding that Qantel had made false representations to CSE with reckless disregard for their truth or falsity

11
 Qantel does not press in this appeal other grounds asserted before the district court in support of its motion for a new trial

12
 CSE's counsel's "Pontius Pilate" remarks, cited by the district court, probably were the most outrageous:
But it comes down to you.  I can't do it.  You can.  Mr. Dignan's arguments, his jigsaw puzzle, amounts to the question, what is truth?    History tells us that 2,000The Story

* * *

JUNI is before any the story of a passionate Norman woman !

Aurélie LECORNEUR was born in France in Normandy where she stayed up to the age of 17 years. To pursue her envy and her studies, she leaves the region after scientific first studies. Fascinated from her youngest age by the creation, she integrate a Preparatory school for entrance to High school of Arts then a two-year technical degree in Industrial design which confirm her envy to create and integrates in 1996 one of the famous Parisian schools of design : the ENSCI, more known under the name “Les Ateliers” where she is awarded a diploma in 2001.

Thus, after fourteen years in Paris, shared between creation and development, very high-end accessories for our friends dogs


is only in the investigation phase of the program, according to a defense official.

Lithuania is also in the market to replenish its ammunition stocks. The country’s inventory fell particularly during the financial crisis beginning in 2008, when the defense budget decreased.

And some of types ammunition, particularly in the larger calibers, will age out before use based on the current training program schedule, an official noted.

The ministry is engaged in a large effort to reduce the shortage gaps and with the increase in the budget, Lithuania is beginning to invest heavily in replenishment of stocks and training ammunition.

And Lithuania is benefiting from a U.S. decision to allocated $100 million to bolster munition in the three Baltic states.

Simulation is also helping Lithuania manage its training-ammunition shortage. “Lithuania has prepared andrate that various fluids are delivered to the processing chamber. Typically, fluids are supplied to the gas panel from vessels or the processing facility""s central supply. Generally, when one of the fluids being transferred between the gas panel and the process chamber poses a safety or environmental threat, the fluid lines, valves and/or fittings are equipped with a containment apparatus to prevent any leaking fluid from entering the environment.
For example, one example of a conventional containment apparatus is described in U.S. Pat. No. 6,298,881, issued Oct. 9, 2001 to Curran et al. Curran et al. generally describes a valve having a primary seal for retaining working fluids and a containment seal that circumscribes the primary seal. The containment seal is generally an elastomer compressed to seal the valve


spectral imaging application that uses the
Gemstone detector and rapid kV switching to acquire dual energy
samples from a single source. By rapidly switching between two
different kV energies at a rate of up to 0.25 ms with sub-millimeter Z-axis
registration, its temporal registration is over 165 times faster than
other dual energy technologies. And the advantage of its single source
architecture is the ability to generate material decomposition images
over the full 50 cm field of view.

We addressed and improved the GSI experience to seamlessly
integrate with AW applications and to significantly reduce
reconstruction times. It’s a breakthrough in spectral CT technology
that effortlessly processes gigabytes of data at a time, making the
clinical benefits of GSI routinely accessible.

The clinical benefits of GSI Pro include up to a 50 percent
improvement in beam-hardening artifact due to bone, metal andways and relations
It gives
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California Junior College before changing to Butler Junior College will enroll for fall semester 2017 and have 2 years of eligibility remaining. The athletic lineman has recently been hearing from schools such as Houston, UCF, TCU, Iowa St., Arizona St., and UK but described the coaches and how they impacted him committing to Louisville “I liked Coach K (Klenakis) the oline coach, I liked his attitude toward the game and the vibe I got from him.” Palmer said. Not only was Palmer impressed with Coach Klenakis, but he also talked about Coach Petrino and the opportunity to play for such a big named coach “Coach Petrino wins. It’s what he does. And to be able to play for as big of a name as big and widely renownedin the 2018 NFL Draft, but he shouldn't have risked damaging his draft stock.

The Verdict: Bad move

Mason Rudolph, QB, Oklahoma State

Height: 6-5. Weight: 235.

Projected 40 Time: 4.85.

Projected Round (2017): 3-5.

Mason Rudolph had a slim chance to be chosen in the second day of the draft, but was probably going to be taken early on Day 3. Rudolph is making the right choice in going back to school; by doing so, he can improve his draft stock and perhaps cement his second-day status in the 2018 NFL Draft, despite being part of a better draft class.

The Verdict: Good move

Courtland Sutton, WR, SMU

Height: 6-3. Weight: 205.

Projected 40 Time: 4.48.

Projected Round (2017): 1-2.

This decision is pretty surprising. There's been talk about Courtland Sutton having a decent chance of being chosen in


logging six sacks, but has just a slim chance to even be chosen in the first half of Day 2. Had Sickels returned to school and had a monster senior campaign, he may have been in the first-round conversation. As it stands now, he'll probably be a third-round pick with a chance to sneak into the second frame. That said, there's something to be said about not risking injury, so while I don't agree with Sickels' decision, I definitely understand it.Neutral moveIt's a bit surprising to see Chad Hansen declare because he's seen extensive action for only one season in 1-A football. Granted, he had a great year, catching 92 passes for 1,249 yards and 11 touchdowns, but the lack of experience will certainly harm his potential. Thatit could prompt some teams to completely remove him off their board. Godchaux is still almost certain to be a second-day selection, so I can't completely call this a bad decision, but he could've done better with another year at LSU.Neutral moveA few weeks ago, Malik Hooker told everyone that he was "100-percent sure" he would be going back to Ohio State next year. Well, whether it was the Buckeyes' blowout loss to Clemson, or the realization that he would be chosen extremely early in the 2017 NFL Draft, something changed since then because Hooker has announced that he will be entering the draft.Hooker, who has drawn comparisons to Ed Reed, is now one of the top prospects in the 2017 class. He could go as high as


drafted.IrrelevantJalen Tabor has seen his stock slip this season. He's still projected as a first-round prospect, however, so it's hard to criticize this decision. Tabor is making the right choice to go pro. Though he could potentially rebound in 2017, he could also slip further, so he shouldn't risk it.Good moveCharles Walker has been enjoying a solid 2016 campaign. He's likely to be chosen on the second day of the 2017 NFL Draft as a result. I don't think he could've entered first-round territory with another season, so he could've risked falling had he returned to school, with either declining play or injury. Thus, Walker is making the right move.Good moveMike Williams' decision to declare for the 2017 NFL Draft seems so much better after his dominant performance<= 0)
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Q:

how to get last day of year from given date?

Anyone can give me a solution to ?
I want to get last date of year base on given date not the last day of the current year
Ex:
$date2 = '2014-03-17';

$date1 = '2015-01-02';

$date = '2016-08-17';

I want to get this:
$date2 = '2014-12-31';

$date1 = '2015-12-31';

$date = '2016-12-31';

A:

Try this:
echo date("Y-m-d", strtotime("Last day of December", strtotime($date)));

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unerring devotion to her, the hive, and their fellows, and they perform the jobs they are given from birth until death. Though they do apparently have pastimes, choose family names for themselves, and maintain a semblance of a social life below ground, such frivolities are strictly controlled by a natural caste system, and a true hill dwarf is a tiresome centre of conversation; his mind wanders constantly, and without his queen near him he is a little like a puppet without a hand. From the bullish, muscular soldiers, to the squat, mute workers, to the reedy, pale scouts, every dwarf lives and dies for his queen.

A queen will mate with almost all of the dwarves in her hive in her lifetime – mostly she will produce new male


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Visual Center

Find the visual center of your images.

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as before to find that the motivic class of stack ${\operatorname{Coh}}_{{\underline{\mathbf{b}}}}^{(0,*\neq 0)} ({\mathbb{C}}^{2})$ is just 1 so that we get $$\begin{aligned}
\sum _{{\underline{\mathbf{b}}}} \left[{\operatorname{Coh}}_{{\underline{\mathbf{b}}}} ({\mathbb{C}}^{2}) \right] {\underline{\mathbf{t}}}^{{\underline{\mathbf{b}}}} &= \left(\sum _{{\underline{\mathbf{b}}}} {\underline{\mathbf{t}}}^{{\underline{\mathbf{b}}}} \right)^{{\mathbb{L}}+1+{\mathbb{L}}^{-1}+{\mathbb{L}}^{-2}+\dotsb }\\
&=\prod _{k=1}^{\infty }\prod _{m=1}^{\infty } (1-t_{m})^{-{\mathbb{L}}^{2-k}}\\
&=\prod _{k=1}^{\infty }\prod _{m=1}^{\infty } (1-{\mathbb{L}}^{2-k} t_{m})^{-1}.\end{aligned}$$

Proof of Euler’s formula
------------------------

Applying the argument of § \[subsec: proof of Feit-Fine\] to the affine line instead of the affine plane gives us a geometric proof of a more elementary formula due to Euler. Let $${\operatorname{Coh}}_{n} ({\mathbb{C}})$$ be the stack of length $n$ coherent sheaves on the affine line. It is equivalent to the stack of ${\mathbb{C}}[x]$ modules of dimension $n$ and hence $${\operatorname{Coh}}_{n} ({\mathbb{C}}) \cong {\operatorname{End}}(n)/GL (n).$$ Similarly, the stacks of coherent sheaves supported at the origin and away from the origin respectively are given by( www.hqcatalyst.com ), ... series of important events since September 2011 to continue ... SEQUOIA CAPITAL INVESTMENT ... announced the selection of Sequoia Capital as its investment ...

... Per-fit™ flexible PVC tube with a tapered ... designed to reduce insertion force and more ... kit s unique obturator/dilator design is engineered ... an easier transition through the tissue into ...


the court to order the return of $57 million in government funding that company received.

"I think it is impossible not to conclude there are problems with the program," Mr Sims said, in his strongest comments yet relating to the troubled VET FEE-HELP system.

"For a program to allow this to be occurring is a problem ... it's often very hard to close the door after the horse has bolted, I know the Commonwealth is now aware of it."

Mr Sims said he expected to take at least one, if not two, further private training providers to court before Christmas.

Phoenix Institute is run by listed company Australian Careers Network (ACN).

ACN today notified the share market that regulatory watchdog the Australian Skills Quality Authority (ASQA) was seeking to cancel registration of PhoenixAtlantic cod (Gadus morhua L.) possesses three homologues of ISG15 with different expression kinetics and conjugation properties.
Two new interferon stimulated gene 15 (ISG15) family members were identified in a subtractive cDNA library constructed from a mixture of head kidney and spleen of Atlantic cod (Gadus morhua) stimulated with polyinosinic:polycytidylic acid (poly I:C). Two full-length Atlantic cod (Ac) ISG15-2 and AcISG15-3 cDNAs were cloned with rapid amplification of cDNA ends (RACE). The cDNA sequence of AcISG15-2 encodes a 16.9kDa protein and AcISG15-3 encodes a 18.4kDa protein, both of which possess the characteristic structural features of two tandem ubiquitin-like domains and the LRGG motif necessary for conjugation. Furthermore, the AcISG15-3 protein is expressed with a C-terminal extension in common with the human ISG15 protein. Gene expression analysis using quantitative reverse


You Should Know About Me

Helena Felc
They're my school
Director of International Sales, EQUA products. Previously Marketing, Spletnik d.o.o..
Peter is always in search for new ideas and he finds the energy, time and motivation to dedicate to them fully with great enthusiasm. With h ...
is current experiences I am confident to say he would be able to turn a bright idea into a successful business.

Let me know if I can return the favor to you >> [link]

Thanks again,
Peter

Dejan Rupnik
They're my friends
Previously Software Developer, HERMES SoftLab. Previously Software Engineer, Evolve d.o.o.
Beacuse he is very keen in wide spectrum of technologies and he is a real hacker :). And in other ways, he knows how to deal with people.

Let me know if I can return the favor to you >>and methods {#sec002}
=====================

A framework to select and cluster mobility profiles {#sec003}
---------------------------------------------------

We propose a general framework (see [Fig 1](#pone.0195714.g001){ref-type="fig"}) to organize and classify human mobility patterns based on individual trajectories constructed from mobile phone data. This type of data is gathered and stored by cell phone carriers (in our case, Sonatel) during communication events between their clients, providing the so called Call Detail Records (CDRs).

![Data processing work-flow.\
D4D Dataset is processed for computation of IT-Matrix, which is processed to select and cluster mobility profiles. Finally, consistency assessment/fusion of profiles with other sources of data, *O*(*l*, *t*) (which depends of the *l* location and *t* time variables), such as livelihood calendars provided by WFP (World Food Program), NDVI (Normalized Difference Vegetation Index \[[@pone.0195714.ref024]\]) and Rain variables. Dark green rectangle represents information


agriculture monitoring {#sec015}

Mobility profiles were assessed and evaluated with external data sources of environmental and agricultural variables ([Materials and methods](#sec002){ref-type="sec"}). Satellite remote sensing is widely used in agriculture monitoring as it is particularly suitable for providing a timely and accurate picture of crop status and conditions over large areas with high revisit frequency \[[@pone.0195714.ref042]\]. The time series profile of the NDVI index (see [S2 Note](#pone.0195714.s002){ref-type="supplementary-material"}) delivered critical information on the phenological dynamics of an agricultural landscape (start of the season, peak of the season, start of senescence, etc.) \[[@pone.0195714.ref043], [@pone.0195714.ref044]\]. Rainfall estimations obtained from the NASA-TRMM project \[[@pone.0195714.ref045]\] data were processed and aggregated in a coarse resolution for a temporal indicator of the rainy season (see [S2 Note](#pone.0195714.s002){ref-type="supplementary-material"}). We integrated these variables with the mobility profiles ([Fig 6](#pone.0195714.g006){ref-type="fig"},\[[@B27], [@B26]\], nonalcoholic fatty liver disease \[[@B21]\], migraine \[[@B12]--[@B24]\], fever \[[@B10], [@B19]\], depression \[[@B21], [@B22]\], acquired immune deficiency syndrome (AIDS) \[[@B16]\], and asthma \[[@B13]\]. 21 RCTs compared the effects of CHM formula granules versus placebo granules based on conventional therapy and involved the treatment of 9 conditions. These conditions include Parkinson\'s disease \[[@B33]--[@B41]\], COPD \[[@B29]--[@B31]\], chronic hepatitis B \[[@B46]--[@B48]\], diabetic peripheral neuropathy \[[@B32]\], depression \[[@B42]\], angina pectoris \[[@B43]\], myasthenia gravis \[[@B44]\], herpes simplex keratitis \[[@B45]\], and liver cirrhotic ascites \[[@B49]\].

The total composition of the CHM formula was described in 37 studies \[[@B10]--[@B46], [@B49], [@B26]\] and, among them, 32 studies described the dosage for each kind of the granule. 28 studies described the ingredients of the placebo which included a small dose of CHM formula granules in 6 studies


granules only showed a positive result, such as chronic hepatitis C, nonalcoholic fatty liver disease, depression, and fever, and another 50% studies showed a negative result, such as HBV carrier, HBV recrudescence, and migraine. Four studies treated by the notifying kidney formula evaluated the effects on HBV carriers. The pooled result of 4 studies cannot demonstrate that the notifying kidney formula granules had the superior effect with placebo on the clearance of serum HBV DNA and HBeAg in HBV carriers with a RR (and the 95% CI) of 2,97 \[0.74,11.91\] and 1.99 \[0.93,4.29\], respectively. Pooled analysis of 3 studies showed that Qizhu granules had a significant effect on clearance of HCV RNA with a RR (and 95% CI) of 6.26 \[2.16,18.16\]. The pooled result showed the heat-clearing andIn the 7 chronic hepatitis B studies \[[@B14], [@B17], [@B20]--[@B25], [@B46], [@B48]\], slight abdominal distention, loss of appetite, and abdominal discomfort appeared in 28 participants, 21 in the CHM formula granules group, and 7 in the placebo group. In addition, mildly raised ALT levels were found in 8 participants in the CHM formula granules group. In the 3 depression studies, dry mouth, nausea, abdominal distention, and dizzy were found in 25 participants, 15 in the CHM formula granules group, and 10 in the placebo or conventional therapy group. In the herpes simplex keratitis study, nausea and diarrhea were found in 4 patients in the CHM granules group. In the 8 with Parkinson\'s disease, pneumonia was found in 1 participant in the CHM granules group, and stomachache in 2


import { Component } from '@angular/core';
import { of } from 'rxjs';

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  languages1 = [{name: 'c'}, {name: 'C++', disable: true}];

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136 shown in green. For clarity, only two subunits are depicted. **b** In the presence of crosslinker, the cysteine-pair mutant S129C-F135C MTS-1-MTS migrates on SDS-PAGE as a tetramer, whereas reduced S129C-F135C migrates as a monomer. Both samples are of reconstituted proteoliposomes and are representative of at least *n* = 20 gels. **c** All six mutant-crosslinker combinations migrate as tetramers and are representative of at least *n* = 10 gels. **d** Native mass spectrometry using collision-induced dissociation in the gas phase results in loss of signal for wild type and reduced cysteine-pair mutants, but not for covalently crosslinked mutants. Spectra for wild-type (upper) and dibromobimane-linked A133C-T136C (lower). **e** Comparative cross-sectional slices through crystal structures at the Tyr132 collar. Only the inner helices are shown. Crosslinkers are depicted as yellow


No K^+^ = (Na^+^~i~/NMDG^+^~o~/ionophore= monensin); KirBac3.1 + spermine (500~i~/1000~o~ μM). M1M = mts-1-mts; DBB = dibromobimane; S--S = disulfide.

Examples of normalized data (Fig. [4b](#Fig4){ref-type="fig"}) and a data summary are presented (Fig. [4c](#Fig4){ref-type="fig"} and Supplementary Table [4](#MOESM1){ref-type="media"}) (Supplementary Fig. [7](#MOESM1){ref-type="media"}). In both wild-type and cysteine-less KirBac3.1 proteoliposomes, the fluorescence decrease occurring post CCCP addition indicates K^+^ flux occurs through the K^+^ channels. Control samples comprising liposomes reconstituted with buffer-only were used to determine baseline fluorescence. A 'null' liposome reconstitution control, prepared from comparably purified material obtained by isopropyl-β-D-thiogalactopyranoside (IPTG) induction of *E. coli* cells transformed with an empty expression plasmid, showed baseline signal. Moreover, tryptic digest mass spectrometry of samples prior to reconstitution showed no detectable contamination by *E. coli* ion channels, transporters or porins. To verify selectivity for K^+^, the salts inKir channels, control over ion flux is not explained by the canonical pore-gating model of conformational change and that, although some K^+^ channels conduct through very wide pores, the width is not essential; the limiting aperture for conduction is effectively set by the ionic diameter of K^+^ (\<3 Å). Interestingly, a recent study noted spontaneous transition of K^+^ from bulk to cavity through a narrow aperture, which is also inconsistent with the constriction acting as a gate^[@CR51]^. There are several possible alternatives to the canonical model. In BK^[@CR45]^ and K2P^[@CR47]^ channels, the idea that gating occurs at the selectivity filter is gaining in acceptance as a way to explain how a wide pore might deactivate without narrowing. In Kir channels a selectivity filter gate may also have relevance^[@CR18]^,