type - that's what they're there for, after all!

I added an index on the columns that are used as foreign keys in the JOIN to speed up the query

I added a computed column that encapsulates the whole if it's approved, use the ApprovedDate, otherwise the IssuedDate logic into one place - makes the query much easier to read! Since this is a pseudo-DATE (time portion is zeroed out), this basically takes care of all the ugly CONVERT / ISNULL and SUBSTRING statements you had (repeatedly) in the query.

So here's my changed script to create the temp table
CREATE TABLE #Changes
    (
    ID INT IDENTITY(1,1) NOT NULL PRIMARY KEY CLUSTERED,
    [GUID] varchar(250),
    Value numeric(36,6),
   DocumentNumber varchar(250),
    Approved numeric(36,6),
    ApprovedDate DATETIME,
    IssuedDate DATETIME,
    Category varchar(250),

    ApprovedOrIssuedDate AS CASE
                               WHEN Approved = 1
                               THEN DATEADD(DAY, 0, DATEDIFF(DAY, 0, ApprovedDate))


close to. It should go without saying that if you want to save the most money on your Steam purchases and your intended purchases aren’t time-sensitive, then you should wait for the next annual summer sale. SteamGameSales is a website. Oct 12,

In Estonia, it’s inconceivable that you would line up to fill in a form, apply for a document or even vote. Everything, from getting medical records to paying taxes, is done online. Each citizen has a unique digital identity and chip card to.

New You, New Credit Card. Change to the KBC Credit Card and Get 0% interest balance transfers for the first 6 months & great bonus cash rewards.

Mar 17, 2017. Yes, that's right. But you might think that the title is a bit too outdated sincecinematic depiction of inwardness. In short, inwardness...

11. The Romance of the Intellectual in Godard: A Love–Hate Relationship

Godard’s signature method of blending documentary and fiction has
yielded many fascinating results, including a cinematic deconstruction of
the figure of the intellectual and his or her vocation. This Nouvelle Vague
filmmaker repeatedly used real-life public intellectuals to interact with
fictional characters in some of his most politicized films, like Brice Parain...

Part IV: Formalist Legacies: Narratives and Exhibitions

In the penultimate chapter to Narration in the Fiction Film, David
Bordwell undertakes to analyze a set of films whose stylistic constructions
adhere to a delimited mode of film narration, termed “parametric narration.”
He defines parametric films as those in which the “stylistic system
creates patterns distinct from the demands of the syuzhet system [or...

13. “A Place of Active Judgment”: Parametric Narration in


a pungent odor, something, he said, he had never smelled before.He lifted a shell. Oily paste oozed from a crack. “That doesn’t look like pond water,” said his team leader, Staff Sgt. Eric J. Duling.

Massive Amounts of WMDs Were Found in Iraq

Massive Amounts of WMDs Were Found in Iraq:

The specialist swabbed the shell with chemical detection paper. It turned red — indicating sulfur mustard, the chemical warfare agent designed to burn a victim’s airway, skin and eyes.

All three men recall an awkward pause. Then Sergeant Duling gave an order: “Get the hell out.”

That led to more discoveries including one cache of 2600 rockets armed with chemical weapons. At the time, Jarrod Lampier, a now retired Army major said that he was ordered to make a statement downplaying theOchs and Blunier as to charges 1, 2 and 3. A summary of the facts regarding the first three charges follows.
Tammie Lacks (Tammie), the complaining witness, testified at the Board hearing that she arrived at the Heart of Illinois Fair in mid-afternoon on July 12, 1986. She went to the fair with her husband, Bill, who then went to work at the fair for the Crystal Ice Company about 4 p.m. After Bill went to work, Tammie testified that she walked around with a friend until evening and then met some people who worked at the fair and spent the rest of the time getting cigarettes, sandwiches and coffee for the individuals running the carnival rides. Bill got off work at 10 to 10:30 p.m., at which time


stated she had to go to the rest room, and the tall fireman said he also had to use the rest room and went over to a beam holding up the rafters and told Tammie to come over with him. She said no, but the shorter fireman grabbed her arm and took her over to the pole "[k]ind of with force but not too forceful." The tall fireman then pulled his zipper down, exposed his penis and asked Tammie to hold it. She stated that each time he tried to pull her hand to his penis she pulled her hand away. After the tall fireman urinated, he attempted to force Tammie's head to his penis and she kept pulling away stating she had to go to the restproceeded to ask each fireman questions not particularly related to the alleged events of July 13, 1986, i.e., name, age, marital status, etc. Upon Sorensen's first question having to do with the time period of midnight to 8 a.m. on July 13, 1986, the firemen's counsel, Mr. Sonnemaker, interjected and advised that the firemen were invoking their constitutional rights under the fifth amendment and would answer no questions regarding that particular time frame. Mr. Frye then again ordered each fireman to answer the question or be subject to disciplinary action. Defendants' counsel, Mr. Eric Margolis, stated, "for the record," that each fireman had refused to answer despite a direct order to do so and under threat of disciplinary action "which would be an exception to [the] right to


31, 1988, wherein it imposed a 30-day suspension against plaintiffs and further directed that plaintiffs not be reinstated until the termination of any appeal or the expiration of time for filing such appeal. The Board clarified, however, that it was imposing this sanction "solely for the purpose of complying with the judge's order."
In its order of September 6, 1988, the circuit court determined the Board's decision of August 10, 1988, to discharge plaintiffs was "unreasonable, arbitrary, capricious, unrelated to the requirements of the service and against the manifest weight of the evidence." As support for its decision the circuit court stated:
"3. That the circumstances surrounding the conduct of the city's investigation mitigate the gravity of the offense for the following reasons:
(a) The questions propounded to the plaintiffs wereThe microstructural, melting, rheological, and sensorial properties of high-overrun frozen desserts.
Air incorporated during dynamic freezing influences the development of the microstructure and the final texture of frozen desserts. Frozen desserts were manufactured with 100-175% overrun from a constant ice cream mix formulation. Microstructural elements (fat, air, and ice phases) of the frozen desserts were then investigated and related to the melting, rheological, and sensory properties of the product. Mean ice crystal and air cell size were found to decrease with increasing overrun, and the extent of fat destabilization increased. Frozen desserts manufactured with higher overrun had slower drip-through rate and better shape retention after melting at ambient conditions, demonstrating that fat destabilization and the interplay of fat, air, and serum phases affect the melting behavior. Structural elements also


A compressor impeller, represented by a compressor impeller for a turbocharger for instance, is conventionally manufactured by placing a workpiece having a shape of a cone or a truncated cone on a supporting pedestal and then cutting the lateral face of the workpiece with a machine tool or the like while the center portion of the workpiece is being pressed in the axial direction to be fixed on the supporting pedestal by a fixing device provided on the opposite side of the supporting pedestal or by a female screw which corresponds to a male screw provided through the impeller. Patent Document 1, for instance, discloses an invention related to a machine tool for machining a compressor impeller for a turbocharger as a conventional technique related to the preventefficiency (qPCR~eff~= \[10^(-1/slope)^-- 1\] × 100; Table [1](#T1){ref-type="table"}). The plasmid template reactions were also run in triplicate. Dissociation curves (Fluorescence \[-R\'(T)\] over T°C) and gel electrophoresis confirmed the presence of single amplicons in all qPCR reactions.

######

Key-site haplotypes for LWS opsin duplicates in fish and humans.

  Key Site Position     Guppy LWS S180   Guppy LWS A180   Guppy LWS P180   Guppy LWS S180r   Killifish LWS A   Killifish LWS B   Rice fish LWS A   Rice fish LWS B   Zebrafish LWS 1   Zebrafish LWS 2   Cave fish LWS g101   Cave fish LWS g103   Human LWS   Human MWS
  --------------------- ---------------- ----------------


with five of these including the start codon, all exons and introns, and part of the 3\' UTR (see Additional file [3](#S3){ref-type="supplementary-material"}). Thirteen *LWS A180*sequences were obtained from seven guppies. Only one was full-length but six included sequence from exon II to the 3\' UTR. The *LWS A180*sequence appears to be a naturally occurring hybrid in the Cumaná guppy; the first five exons and four introns are most similar to *LWS S180*, whereas the last intron and exon are identical to the *LWS P180*locus. As the two regions of this hybrid *LWS A180*sequence will give conflicting phylogenetic signals, the *LWS A180*sequences were truncated in the phylogenetic analyses reported below (i.e. only the first five exons were utilized). Seven *LWS P180*sequences were obtained from seven guppies (see Additional filetheir Paria River guppy. The phylogenetic relationships among guppy LWS opsin paralogs reported by Weadick and Chang \[[@B24]\] differ from those shown here. Both topologies were produced using maximum parsimony, but by surveying more individuals, more species and by obtaining longer sequences we have produced a larger set of parsimony-informative characters. This is most evident when considering the relationship between *LWS P180*and Weadick and Chang\'s variant 5, and variant 4. The large number of differences between variant 5 and variant 4 are apparent in Weadick and Chang\'s \[[@B24]\] tree where maximum likelihood branch lengths have been superimposed on the MP topology. Nonetheless, in their analysis, these two sequences form a monophyletic group. However, the sister sequence relationship between variant 5 and variant 4 disappears with the addition of


during their lifetime \[[@B65]\] and thus differential use of opsin gene duplicates in different habitats is an unlikely explanation for the evolution of LWS opsin gene diversity in this taxon.

The simultaneous expression of opsin paralogs with different sensitivities might expand the region of the spectrum where the guppy possesses high sensitivity and expand the range of detectable wavelengths. This enhancement and broadening of wavelength sensitivity can occur when individual cone cells express more than one opsin gene \[[@B66]\] or when adjacent cone cells express different opsins (e.g., humans and transgenic mice -- see below). MSP data in guppies showing cells with a broad range of sensitivities in the long wave region of the spectrum \[[@B18],[@B19]\] are consistent with the hypothesis that the sensitivity of some cones is aconsequence of the co-expression of different LWS opsins. By providing guppies with a broad region of maximum wavelength sensitivity, LWS opsin gene duplication and divergence might make multi-colored male guppies appear brighter (more conspicuous) \[[@B67]\] to other guppies, but not to predators with wavelength sensitivity limited (by LWS opsin gene copy number) to a narrower region of the spectrum.

Expression of different LWS opsins in adjacent cones not only improves overall spectral sensitivity, but is the basis of wavelength discrimination. Observations from humans and mice are consistent with the hypothesis that opsin gene duplication and divergence can lead to better color discrimination even without any associated revisions to neuroanatomy. Among human women who are heterozygous at either the LWS or MWS locus, some appear to have a pattern of


reaction included an initial denaturation of 94°C for 30 seconds and a final extension of 72°C for 600 seconds. If \>1 bands were found after gel electrophoresis, expected sized amplicons were cut and purified using a QIAquick^®^Gel Extraction Kit.

######

Click here for file

###### Additional file 3

Primer and sequence maps for LWS opsin loci in Poeciliidae. Large colored boxes and horizontal bars represent exons and introns, respectively. Black and solid horizontal lines represent genomic sequences amplified using various PCR primer combinations (see legend; see Additional files [1](#S1){ref-type="supplementary-material"} and [2](#S2){ref-type="supplementary-material"}). Dotted horizontal lines represent mRNA transcripts acquired through RT-PCR from cDNA samples. \"n\" represents the number of times a given sequence of near perfect identity had been acquired. Key site amino acids are shown within their respective exons. Inter-species andscenario suggests that there may be smaller objects in orbit around MU69. Finding satellites would also help reveal the body’s total mass and average density, which are key for pinpointing its interior structure and composition, Moore said. “We have not found any other bodies in the system,” he said, “but we’re still looking.”

5. Slowly Rotating

The object “rotates with a period of about 15 hours,” said mission coinvestigator Cathy Olkin from SwRI. What’s more, MU69 rotates in such a way that it keeps roughly the same surface area facing Earth at all times, she said, similar to an airplane propeller. An impact with a smaller object may have slowed down MU69’s initial rotation from about 4 hours to its current 15-hour period, the team said.

6. Old and Primitive

“What we’re


Some topography can be seen in this image by viewing through red and blue 3-D glasses. Credit: NASA/Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute

The first close-up of MU69 sent back was not at the right angle to show small-scale elevation changes from craters or ridges. Neither was the second. When the team combined the two, however, they were able to create a low-resolution stereographic image that shows some high and low reliefs.

“You see how narrow the neck is, and we also get a sense that bright spots may be associated with topographic lows,” said Paul Schenk, a New Horizons coinvestigator from the Lunar and Planetary Institute in Houston, Texas. “This may indicate downslope movement of material from topographic highs like ridges. This may be an indication thatis processed can switch in different tissues and at different developmental times ([@b22]; [@b23]; [@b5]; [@b3]). Although these studies have suggested that a change in arm usage provides a mechanism to evolve the function of a miRNA gene locus, the nature of the molecular events that lead to such changes has been largely unexamined. The potential functional consequences for evolutionary changes in the processing of the miRNA duplex are profound, as mature miRNAs from opposite arms might target different mRNAs. Here, we combine comparative genomics and deep sequencing to reconstruct the evolutionary history of changes in arm usage in the ancient miR-100/10 miRNA family. We use a cell culture-based assay to quantify miRNA abundance and determine that the sequences that direct this choice must be outside the miRNA


miRVana miRNA isolation kit (Ambion). RNA was size selected (for less than 40 nucleotide) with a flashPAGE fractionator (Ambion). Purification was then performed with a flashPAGE reaction clean-up kit (Ambion). A library was constructed using the SOLiD Small RNA Expression Kit, according to the manufacturer\'s instructions (Ambion). To meet the sample quantity for SOLiD sequencing, the complementary DNA libraries were then further amplified using 15 cycles of PCR. The final products ranging from approximately 105 to 150 bp were purified and size selected. SOLiD sequencing was carried out at the Centre for Genomic Research at the University of Liverpool. Adaptor sequences were removed from the 3′ ends of reads, and reads were mapped to the Baylor release 3.0 of the *Tribolium* genome using Bowtie 0.11, with no mismatchesDrosha. Dicer cleavage yields the mature miRNA duplex, and the dominant arm targets the RNA-induced silencing complex to mRNA transcripts. The sequences of the mature miRNA duplex produced by Dicer cleavage are identical in *D. melanogaster* and *T. castaneum*; yet, the 5′ arm (magenta) dominates in *Tribolium* and the 3′ arm (blue) dominates in *Drosophila*. The sequence signals controlling arm dominance are therefore outside the mature miRNA duplex, and the arm choice must be specified before Dicer cleavage (that is, above the dotted line). miRNA, microRNA.](embor2010191f3){#f3}

###### Predicted targets of mature miRNAs derived from the 5′ and 3′ arms of miR-100/10 family members

  **Target type**


of this crowd, which pretty much blanketed Lawyers Mall, there was no doubting, no hanging back.

“We need 21st Century schools,” said Betty Baze, of Cherry Hill, who volunteers her time to tutor pre-schoolers there. Baze praised the school staff and fellow tutors (from AmeriCorps and AARP) but said the conditions in the building are deplorable.

“When it’s so hot in the summer, when you have to bundle up inside the classroom in the winter, when you can’t drink from the water fountains, when the bathroom plumbing is constantly backed up, you can’t learn,” said Baze, who attended Arundel Elementary School as a child in the 1950s and finds it “much different, much deteriorated” today.

Along with the adult speakers, the organizers brought up schoolchildren who performed music-and-dance numbers (“Pass thatLectin binding of surface epithelia and concomitant glands of gallbladder and biliary ducts in the guinea pig.
Complex carbohydrate components of secretory granules and the glycocalix were analysed in surface epithelia, endoepithelial glands and exoepithelial tubuloalveolar glands of the biliary-ductular system (guinea pig). Brunner glands and pyloric glands were studied for comparison. The columnar epithelial cells of the gallbladder and biliary ducts displayed a well-developed PAS-positive apical glycocalix. These materials strongly bound Ricinus communis A I, Ulex europaeus I, Lotus tetragonolobus A and wheat-germ-A lectins. With the exception of Lotus A lectin which did not bind at all, the same lectins stained the basolateral cell surface. The secretory granules in the supranuclear regions of surface epithelia and in the exoepithelial glands strongly bound Ricinus A I, Ulex europaeus I,


The FTSE has closed at a six-week low, as speculation over a US interest rate rise and Hillary Clinton's health troubles rattled investors.

The FTSE 100 index closed down 76.1 points or 1.12% as global markets reacted to the US Democratic presidential candidate being diagnosed with pneumonia just weeks ahead of the US election.

In addition, concerns have also grown over the likelihood of the US Federal Reserve increasing interest rates next week when the committee meets on 21 September.

Boston Federal Reserve president Eric Rosengren, has said that the economy of the country would be at risk if there was too much of a delay before an increase takes place.

Jane Foley, a senior FX strategist at Rabobank, said the scare may have spooked investors who are concerned about the economicMonday following a disappointing financial results release in the morning.

Shares in Marks and Spencer also took slumped, dropping 17.4p to 326.2p following the announcement that its executive Laura Wade-Grey will not return to work after maternity leave.

The biggest risers on the FTSE 100 for the day included AstraZeneca up 39p at 4858p and Burberry up 9p at 1262p.


living from the heart. .

Heartsong Review says, 'Scott's music gets better and better. I loved his last album, The Eyes Of God, but he has surpassed the high standards he set then to give us a perfect collection of songs that range from devotional to celebratory, always engaging and heart-stirring.' Scott Kalechstein performs original songs with his guitar and voice. He often spices up his repertoire with songs created spontaneously based on topics suggested by the audience. His intention in his singing and songwriting is to offer both entertainment and education, upliftment and enlightenment. He uses his art as a vehicle to inspire transformation, to fuel dreams, to encourage self-esteem, and to help us lighten up in those places where we all can get weighed down in life.Q:

What does "ebb away" here mean?

Looked up the dictionary. It says flow back. Does it mean "come back" here?

It is an agony that people here are beginning to get used to as time drags on and optimism and hope ebb away. (source)

A:

It says flow back. Does it mean "come back" here?

Flow back, as like "go back", not "come back". Another synonym for these words is "recede".Let's look at the meaning the upper paragraph tries to demonstrate.

While some of the relatives will keep the fire of hope burning, there is the developing, devastating realisation for others that their loved ones will not be found alive.

What does this mean? It means that for instance when Mr.X and Mrs.Y found out that their son's plane has crashed, their relatives gave them


2004, in particular its fidelity to the republican principles I espouse, I gave it a high mark. So what do I say three years later?

In thinking about the future of Spain under the Zapatero government – indeed under any government – I made two serious mistakes. I was naive about the reliability of the international financial system in providing the infrastructure that would enable the government in a country like Spain to provide for its people’s economic welfare. And I failed to realize how far the country’s options for responding to a downturn of economic fortunes would be restricted by its membership in the Eurozone.

I continue to commend the performance of the Zapatero government for its attempts to equalize the position of women in society, for its regularizationmy image, the tiger that they ride – is often presented as a body of individuals with a concerted will of their own: a cadre of international financiers and bankers that acts with a single, self-aggrandizing aim. It would be nice if things were like that, for such an entity would then offer a lightning rod for our outrage, a target for our resentment, an agency that we might expect to be able to censure and hold to account. But alas, as always, things are more complicated.

The tiger that our governments ride is a more wayward and untameable beast than the body imagined in such a conspiracy theory. Its movements are dictated by motives no less self‐seeking and callous than those projected in that theory. But they are


me. "It's creating a product that will make a significant improvement to the health and well being of the populace. That's a success even though the founder and the team may have sold the company long before it had any revenue."

And the notion that a successful CEO stays at the helm for many, many years — think Henry Ford II running Ford for decades — that, too, is no longer true.

"We tell entrepreneurs all the time that if you're successful growing this company to a certain size, the company may outgrow you," Simms said. "You build it to a certain point, you get to your maximum competence as a CEO, and it's time to bring in another person as CEO with the competence required to take it toGhafur Muhammad Khan also served the Holkar ruler, annexing Rajput territories in northern Malwa. For his services, he was designated the title of a nawab. His state existed in modern Madhya Pradesh, comprising the tehsils of Jaora, Barauda, Tal and Barkhera, along with the dependencies of Piploda and Panth-Piploda.
 Radhanpur State (1753–1948), [Jawan Mard Khan Babi II], 1st Nawab, a pathan belonging to the family of last deputy Governor of Gujarat province in Mughal Empire. Nawab Khan Jahan Babi belonged to the Babi or Babai (Pashtun tribe) of Pashtuns , its headquarters were at Radhanpur in present-day Gujarat.
 Junagadh State (1730–1948), 1st Nawab, Muhammad Sher khan Babi, a pathan belonging to the family of last deputy Governor of Gujarat province in Mughal Empire. Muhammad Sher khan Babi belonged


We would like to offer our sincere support to anyone coping with grief. Enter your email below for our complimentary daily grief messages. Messages run for up to one year and you can stop at any time. Your email will not be used for any other purpose.

Pamela G. (Shaw) Henry

September 11, 1945 ~ June 24, 2018 (age 72)

Obituary

Service Details

Tribute Wall

Flowers & Gifts

Pamela G. Henry left this life to be with her Lord on June 24, 2018 in Fishersville, Virginia. She is survived by her devoted husband, Rev. Dr. John F. Henry, and a loving family.
Pamela was born in Chicago, IL and lived her early life in Arizona, but most enjoyed time spent in New England where she later resided. She never tired of seeing the beautiful ocean, travelingas solid circles) were processed for bisulfite sequencing, and five plants from wild type (WT), *msh1* memory (MM) and nonmemory (NM) generation 1 and WT and MM generation 5 were processed for RNAseq at the same time (red outline). Rosette leaf tissues were collected at bolting stage.

Changes in genome-wide cytosine methylation were evident in *msh1* memory and nonmemory lines relative to wild type by comparing genome-wide methylation levels, confirming epigenomic activity (Supplementary Fig. [2](#MOESM1){ref-type="media"}). These data allowed assessment of transgenerational methylation fluctuation. Overall methylation level was higher among wild-type individuals than memory in all six generations. Relying on high data quality (Supplementary Data [1](#MOESM1){ref-type="media"}), rigorous experimental design and large population sizes (30 samples each for wild type and *msh1* memory, Fig. [2](#Fig2){ref-type="fig"}), we estimated probability distributions of methylation signal (divergence of


DSS), root-mean-square test (used by methylpy) and signal detection-machine-learning method (used by Methyl-IT), for classification performance with similar methylation level difference (\>0.25) and *p* value (\<0.05) cutoff (Supplementary Fig. [3](#MOESM1){ref-type="media"}).

The discrimination power or accuracy of DMP calling for each method is evaluated based on performance of classifier models built on DMPs identified by each method. Supplementary Fig. [3b, c](#MOESM1){ref-type="media"} shows the signal detection-machine-learning approach to provide the best overall DMP calling performance among the four methods, with second largest number of DMPs identified, highest accuracy, sensitivity, and specificity and lowest FDR.

Applying a similar procedure to all six-generation datasets showed DMPs from all memory vs. nonmemory and WT vs. memory comparisons at false discovery rate (FDR) \< 0.05 and accuracy \> 90% (Supplementary Table [1](#MOESM1){ref-type="media"}). Downstream analysis with identified DMPs used the signal detection procedure (Supplementaryand CG-associated DMPs within genic regions at higher density (Fig. [4d](#Fig4){ref-type="fig"}).

We applied generalized linear regression analysis (GLM) to test significance of the difference between group DMP counts (WT vs. memory, nonmemory vs. memory) at genic regions (gene body plus 1 kb up- and downstream). Genes with statistically significant difference in DMP counts in memory vs. nonmemory or WT were defined as differentially methylated genes (DMGs). Relying on the robust dataset available (6 generations, 65 samples and 4-Gb reads per sample) and two additional biological filters, network enrichment analysis and heritability, to assess the nature of memory-related genes, we implemented an intermediate stringency cutoff to enhance the gene network resolution power of potential DMGs. This approach identified 6925, 5148, 5603, 7231, 7704, and 6050 DMGs for gen1--gen6, respectively, and 7130 DMGs


around the significance threshold.Fig. 6Circadian rhythm network genes are both differentially expressed and methylated.**a** DMGs for the circadian rhythm (GO:0007623) network in *msh1* memory line. Only genes identified as DMGs in at least four out of seven comparisons (Gen1 to Gen6 WT vs. MM and Gen1 NM vs. MM) are presented. Scale represents the log2 Fold change of DMP number at specific genes in each comparison. **b** DEGs from the circadian rhythm (GO:0007623) network in *msh1* memory line and *msh1* mutant. Only genes identified as DEGs in at least four out of five comparisons (Gen1 WT vs. MM, Gen1 NM vs. MM, Gen5 WT vs. MM, WT vs. *msh1* translatome (TRAPseq) and WT vs. *msh1* TDNA mutant) are presented. **c** DMGs and DEGs presented in panels (**a**) andGI, mainly CG context, was confirmed by targeted BS-PCR sequencing (Supplementary Fig. [18b](#MOESM1){ref-type="media"}).

Significant CHH repatterning in memory prompted us to develop sRNA sequence data for memory and wild-type lines. Samples were derived from Gen1 memory and corresponding wild-type plants. Screening differential 24nt sRNAs from these datasets identified 2999 differentially expressed sRNA clusters and 2847 genes within ±1 kb of these clusters (Supplementary Data [10](#MOESM1){ref-type="media"}), representing similar pathways as in memory line methylome analysis (Fig. [6b](#Fig6){ref-type="fig"}). In all, 913 DMGs from memory Gen1 and 205 DMGs from the 954 heritable DMGs were located within ±1 kb of the sRNA clusters (Supplementary Data [8](#MOESM1){ref-type="media"}, [10](#MOESM1){ref-type="media"}). Among 373 DMGs in four prominent networks (Supplementary Data [11](#MOESM1){ref-type="media"}), 57 were colocalized with differentially expressed sRNA clusters, and individual gene examples are highlighted with a green star in Fig. [6](#Fig6){ref-type="fig"} (circadian rhythm network)


expression and shows heritable methylation differences in *msh1* memory, a factor that may contribute to the observed relaxation of gene expression constraints in *msh1*. The *MET1* promoter is overlapped by a TE (AT5TE71735; Supplementary Fig. [21](#MOESM1){ref-type="media"}) that appears to participate in its heritable methylation repatterning following environmental stress^[@CR44]^.

The hyper-stress condition that arises with MSH1 depletion appears to be unsustainable in the absence of functional *HDA6*. This histone deacetylase has been associated with genes controlling plant circadian clock, ABA stress response, auxin signaling, brassinosteroid signaling and flowering time^[@CR45]^. Histone deacetylases (HDACs) catalyze removal of acetyl groups from acetylated lysine residues in the N-termini of histone proteins that serve as epigenetic marks^[@CR45]^, thus impacting chromatin compaction and gene suppression.

HDA6 interacts directly with the methyltransferase MET1, both in vitro and in vivo^[@CR29]^,was derived from a concentration gradient experiment of four concentrations (0, 30, 50, 100 µM) where 100 µM showed visible impact on plant growth for both wild-type Col-0 and *msh1* memory line plants. Seeds were germinated and grown at 24 °C, 18-h day length, and 120−150 μmol m^−2^ s^−1^ light intensity for 14 days. For longer observation, the 14-d-treated plants were transferred to square pots with soil and grown under standard conditions in the growth chamber. The experiment was repeated three times, with at least 18 replicates per treatment each experiment. This protocol was adapted from Griffin et al.^[@CR63]^.

For the purpose of RNA-seq and methylome sequencing, Murashige and Skoog medium (Sigma, USA) supplemented with 1% (w/v) agar was prepared. 5-azacytidine (Sigma, USA) dissolved in dimethyl-sulfoxide (DMSO) was added to cooling agar at final concentration


Vivaldi 1.1 Fixed A Glitch I Had With Flash and Java Scrip

What ever the changes were in Vivaldi 1.1, they fixed a problem that I was unable to rectify. I use speedtest.xfinity.com to periodical check my internet speed. Although my Firefox and Chrome browsers worked perfectly, no Flash requirements worked with Vivaldi. Whatever you did works for me. Thanksprojection of an effective renewable energy target of 42% by 2030. Some backbenchers believed it would take the Coalition too close to Labor, which has a 50% target. There were also queries about the status of the Paris targets.

But Frydenberg told the ABC: “There was an overwhelming feeling among those in the party room tonight that business-as-usual is not an option.”

Asked on 7.30 “are you going to be able to get your colleagues to agree to support a clean energy target?” Frydenberg replied: “It is too early to say”.

Finkel met with the government’s backbench environment committee on Tuesday to explain his plan and answer questions.

Frydenberg conceded that backbenchers “are concerned about the future of coal”. But he flatly rejected the Abbott suggestion that the Finkel plan amounted to


a be h(r). Solve -4 = l - a for l.
-4
Suppose 7*q = 10*q. Suppose k = -5*d + 48, -40 = -3*d - q*k + 5*k. Solve d = 2*s + 2 for s.
4
Suppose 0 = v - 0*v - 5*a - 19, a = v - 23. Solve 9*w - 3*w + v = 0 for w.
-4
Let y be (-15 + 8)*(-10)/10. Solve -20*b + y*b = -39 for b.
3
Let z(u) = -5*u**2 + 23*u - 9. Let j be z(4). Suppose -4*i + 14 = -6. Suppose c + i = 2*c. Solve -j - 2 = c*r for r.
-1
Suppose 5*o - 5 - 15 = 0. Let j be (-117)/234*(-1 + 1). Solve 2*p + o + 0 = j for p.
-2
Suppose 0 =5*o - 4. Let n be d(3). Solve 0 = -9*r + n*r - 8 for r.
4
Let k(h) = -h**2 - 16*h - 13. Let j be 2*(-3)/18*45. Let b be k(j). Suppose 0 = t - 2*q - 17, -7 = t - 0*t + 4*q. Solve -b*r - t = 1 for r.
-5
Let x = 485 - 467. Solve 0 = s + x - 17 for s.
-1
Suppose -152 = -12*p - 7*p. Solve 15*d - 22 = p for d.
2
Let u be (-2)/(16/(-28))*24/21. Suppose f + u*k + 4 = 3, -4*f + 44 = 4*k. Solve 5*b - f + 0 = 0 for b.
3
Let m be (-24)/(2/(-4) - 1). Suppose -y = y. Suppose -3*q + 6 = -y*q. Solve q*s = -2*s


writing about flying saucer obsessions in the 20th century is exhausting. Recently, Inverse got back in touch with the author to discuss this important Roswell anniversary. This led to an important and relevant insight: “Going by both research and empirical observation, the number of UFO reports dropped off significantly in the early 21st century,” Womack said. He attributes this, at least partially, to the rise of camera phones.

Which makes sense. Arguably, the Eighties and Nineties were the peak of UFO interest in the United States. Proof? The vast majority of famous books published about UFOs and government cover-ups — most notably The Roswell Incident by Charles Berlitz and William L. Moore — were published in these two decades. And yet, once every regular citizen had a camera onto the synthesis of polymeric single-chain nanoparticles (SCNPs) [@Altintas2016; @lyon2015; @reviewcsr; @mavila2016; @hanlon2016; @PomposoSCNPbook] with potential applications in, e.g., nanomedicine [@hamilton2009; @sanchez2013design], bioimaging [@perezbaena2010; @bai2014], biosensing [@gillisen2012single], catalysis [@terashima2011; @perez2013endowing; @huerta2013; @tooley2015], or rheology [@Mackay2003; @Arbe2016; @Bacova2017]. SCNPs are obtained, generally at highly diluted conditions, through purely intramolecular cross-linking of single polymer precursors. A series of investigations by small-angle neutron (SANS) and X-ray scattering (SAXS) [@sanchez2013design; @perez2013endowing; @Sanchez-Sanchez2013a; @Moreno2013] have revealed that SCNPs synthesized through coventional routes are usually sparse objects with open topologies. A compilation of literature results for SCNPs in solution with very different chemical structures [@Pomposo2014a] reveals scaling behavior, $R\sim N^{\nu}$, of the macromolecular radius $R$ with the polymerization degree $N$, with an average exponent $\nu \approx 0.5$. Thus, the SCNP conformations in good solvent


characteristic for Gaussian chains or rings in the fully flexible limit, to values resembling crumpled globular behaviour [@Grosberg1988; @Mirny2011] in the case of very stiff SCNPs. We also characterize the effect of stiffness in the SCNP domains. Increasing stiffness leads to bigger and less deformable domains though, surprisingly, it has no significant effect on their scaling behaviour, which is in all cases similar to that of Gaussian chains or rings. This suggests that it is not the particular internal structure of the domains, but their spatial arrangement which determines the global conformations of the SCNPs (sparse Gaussian-like objects or crumpled globules). Since the intramolecular stiffness can be tuned in real polymers through the specific chemistry of the precursor or by the introduction of bulky side groups, our resultspropose a new route to control the global structure of SCNPs.

The article is organized as follows. In Section 2 we present details of the model and the simulation method. In Section 3 we characterize and discuss the effect of chain stiffness on the structure of the SCNPs and their domains. Conclusions are given in Section 4.

Model and simulation details
============================

We use a bead-spring model [@Kremer1990] to simulate the linear precursors and the SCNPs. The non-bonded interactions between monomers are given by a purely repulsive Lennard-Jones (LJ) potential, $$U^{\rm LJ}(r) = 4\epsilon \left[ \left(\frac{\sigma}{r}\right)^{12} -\left(\frac{\sigma}{r}\right)^{6} +\frac{1}{4}\right] ,
\label{eq:LJ}$$ with a cutoff distance $r_{\rm cut} = 2^{1/6}\sigma$. Connected monomers along the chain contour, as well as cross-linked monomers after synthesis of the SCNPs, interact via a finitely extensible nonlinear elastic (FENE) potential,


has the opposite effect to increasing $k$. It leads to shorter contour distances between consecutive reactive monomers, which favours bonding at short $s$ and partially compensates the disfavouring effect of chain stiffness.

![Distribution of the biggest loop in SCNPs with $k=0$ (a) and $k=8$ (b). Different data sets correspond to different values of the fraction of reactive monomers.[]{data-label="fig:maxloop"}](plot-maxloop-f-k0.eps "fig:"){width=".49\textwidth"}![Distribution of the biggest loop in SCNPs with $k=0$ (a) and $k=8$ (b). Different data sets correspond to different values of the fraction of reactive monomers.[]{data-label="fig:maxloop"}](plot-maxloop-f-k8.eps "fig:"){width=".49\textwidth"}

Though, as revealed by the distributions $P(s)$, long-range loops are unfrequent, most of the SCNPs have at least one big loop of $N > 100$ monomers. This is demonstrated in Fig. \[fig:maxloop\]. For each individual SCNP we identify its biggest loop, of $n^{\rm loop}_{\rm max}$ monomers.weaker dependence of the real-space distance on the contour distance and therefore slightly lower exponents. The power-laws at long contour distances ($s > 20$) are characterized by lower $p$-exponents than at short $s$ and, as in Fig. \[fig:rgloop\], with no significant dependence of $p$ on the fraction of reactive monomers. Again increasing stiffness has the opposite effect in the exponents that at short paths, highlighting the increasing compactness of the global conformations. In a similar fashion to Fig. \[fig:rgloop\], the exponents change from $p \approx 0.5$ for $k = 0$ to $p \approx 0.3$ for $k= 8$.

![(a): Form factors for SCNPs with $f=0.3$. Different data sets correspond to different bending constants. For the sake of clarity each set has been rescaled in the ordinate axis, from bottom to top, by


a factor 1, 2, 4 and 8. Lines are power law fits: $w(q) \sim q^{-1/\nu}$ in the fractal regime $1/R_{\rm g} \ll q \ll 1/b$, and $w(q) \sim q^{-1/\nu'}$ at $1 < q < 4$. Exponents are indicated. (b): Scaling exponents $\nu$ for the fractal regime as a function of the fraction of reactive monomers. Different data sets correspond to different values of the bending constant. A typical error bar is shown.[]{data-label="fig:wq"}](plot-wq-N400L120.eps "fig:"){width=".49\textwidth"}![(a): Form factors for SCNPs with $f=0.3$. Different data sets correspond to different bending constants. For the sake of clarity each set has been rescaled in the ordinate axis, from bottom to top, by a factor 1, 2, 4 and 8. Lines are power law fits: $w(q) \sim q^{-1/\nu}$ in the fractal regime $1/R_{\rm g} \llfractions of reactive monomers. For the sake of clarity each set has been rescaled in the ordinate axis, from bottom to top, by a factor 1, 3, 9, 27 and 81. The solid lines indicate approximate power law behavior $P(s) \sim s^{-x}$ with $1.5 \leq x \leq 1.8$. []{data-label="fig:histogscal"}](plot-histog-k0-f-comp-scal.eps "fig:"){width=".49\textwidth"}

The second, and more relevant, difference is that the SCNPs do not show the approximate scaling $P(s) \sim s^{-1}$ expected for crumpled globules [@Mirny2011; @Halverson2011; @Halverson2014; @Rosa2010]. The decay of $P(s)$ at long contour distances is, for all the investigated values of $k$ and $f$, compatible with power-law behaviour, $P(s) \sim s^{-x}$, but with an exponent $1.5 \le x \le 1.8$ (see results for $f=0.4$ as a function of $k$ and for $k=0$ as a function of $f$ in


both panels of Fig. \[fig:histogscal\]). Similar exponents have been found in a similar on-lattice model for SCNPs [@Rabbel2017]. For the flexible systems the exponent $x \approx 1.5$ can be rationalized by invoking Gaussian statistics of linear chains, for which the return probability of a long segment ($s \gg 1$) scales as $s^{-3/2}$ [@Lua2004; @notedefps].

![Unnormalized distributions (see text) of contour distances between bonded reactive monomers in SCNPs with $f=0.2$. Panels (a) and (b) correspond to bending constants $k=0$ and $k=8$, respectively. Different data sets correspond to different times during the cross-linking run. Lines in panel (a) are fits to power-law behaviour $P(s;t) \sim s^{-x}$, with $x = 2.6$ and 1.7 at early and late times, respectively.[]{data-label="fig:histogtime"}](plot-histogtime-N400L80-k0.eps "fig:"){width=".49\textwidth"}![Unnormalized distributions (see text) of contour distances between bonded reactive monomers in SCNPs with$f=0.2$. Panels (a) and (b) correspond to bending constants $k=0$ and $k=8$, respectively. Different data sets correspond to different times during the cross-linking run. Lines in panel (a) are fits to power-law behaviour $P(s;t) \sim s^{-x}$, with $x = 2.6$ and 1.7 at early and late times, respectively.[]{data-label="fig:histogtime"}](plot-histogtime-N400L80-k8.eps "fig:"){width=".49\textwidth"}

At this point there is an apparent contradiction between the scaling properties found for $k=8$ in the loop size, the internal distance and the form factor (consistent with a crumpled globular structure) and the approximate behaviour $P(s) \sim s^{-x}$ with $x \gtrsim 1.5$ instead of $x \approx 1$ (and hence consistent with Gaussian or self-avoiding chains). Though we do not have a strong argument for solving this apparent contradiction, a temptative explanation can be obtained by analyzing the kinetics of


deformable. This is confirmed for all the investigated systems in Fig. \[fig:domfluct\], which shows the average relative fluctuation of the domain as a function of its size, defined as its number of monomers $n_{\rm d}$. The relative fluctuation is measured as $\delta = [(\langle R^2_{\rm g} \rangle - \langle R_{\rm g} \rangle ^2 )/\langle R^2_{\rm g} \rangle]^{1/2}$, with $R_{\rm g}$ the radius of gyration of the domain. As expected, the smallest domains (a few monomers) are close to the rigid limit ($\delta \rightarrow 0$). The relative fluctuation increases with the domain size, but the domains are still weakly deformable, saturating to a small value $0.05 < \delta < 0.12$. Not surprisingly, increasing $k$ and $f$ (i.e., chain stiffness and cross-linking density) leads to less deformable domains and lower values0.59$ to $y \lesssim 1$, in a similar fashion to self-avoiding chains/rings and rod-like objects, respectively. Somewhat unexpectedly, in view of the trends found for other observables in the previous subsections, the domains of size $n_{\rm d} > 50$ show in all cases an exponent $y \approx 0.5$, irrespective of the degree of cross-linking and chain stiffness. This exponent indicates that in all the investigated cases the SCNP domains are, in average, weakly deformable but sparse objects. However, the analysis of the scaling properties of the whole SCNP (Figs. \[fig:rs\] and \[fig:wq\]) suggests that the chain stiffness and fraction of reactive monomers determines the particular spatial arrangement of the domains, which can result in sparse or in globular arquitectures of the SCNPs.

![Radius of gyration of the domains as a


interconnected loops. The characterization of several structural observables as loop size, intramolecular distances and form factors has revealed a crossover in the scaling behaviour of the SCNPs by increasing stiffness. The scaling exponents change from those characteristic for Gaussian chains or rings in $\theta$-solvents in the fully flexible limit, to values resembling fractal or ‘crumpled’ globular behaviour when the SCNPs become very stiff. Still, the distribution of loop sizes retains the behaviour expected for Gaussian paths even for very stiff SCNPs, since unlike in the flexible limit a high fraction of long loops is formed at the early and intermediate stage of the cross-linking process, where the partially cross-linked precursor is still a self-avoiding object.

Increasing stiffness leads to bigger and less deformable SCNP domains. Surprisingly, the scaling behaviourwill give you the tools to transform your organisation’s culture and develop your strategy to take the ideas from Day 1 into reality.

Happy Workplaces CEO Conference is for Chief Executives who want to get away from traditional top-down, hierarchical organisations, and want to lead high-trust, high-autonomy and high-performance teams.


a dry run.
     *
     * @return bool
     */
    public function isDryRun()
    {
        return $this->dryRun;
    }

    /**
     * @return array
     */
    public function getDebug()
    {
        return $this->debug;
    }

    /**
     * @return bool
     */
    public function isGdpr()
    {
        return $this->gdpr;
    }
}
considered "dirty" in puzzle languages are the easiest or accepted
way. There is often a "cleaner" method of doing things, but the language and
the language's culture don't try to push you towards it. This can make the
non-puzzle languages somewhat easier to work with, because they don't push
more complex abstractions on you, but as a result they lose some of the
expressiveness which forcing abstractions can give.

I'd disagree with him for making such a strict distinction between the two.
It's a bit of a spectrum, based on the degree to which the languages try to
restrict you. For instance, one (debatable) ordering of some languages is
Javascript, Perl, Python, Java, Assembly, Haskell. Note that these
distinctions don't necessarily convey the existence of high-level abstractions
within the languages; it only conveys the degree to which they attempt


1 of 2 View Caption

Trent Nelson | The Salt Lake Tribune Alyson Ainscough takes a moment to compose herself while testifying as the House Law Enforc Trent Nelson | The Salt Lake Tribune Bountiful Police Chief Tom Ross and Rep. Angela Romero, D-Salt Lake City, speak as the Housproject(map-helpers)

include_directories(include)

set(NAMESPACE idx/maphelpers/)
set(HDR_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/include/${NAMESPACE})

set(stlmaphelpers-HEADERS ${stlmaphelpers-HEADERS} ${HDR_DIRECTORY}/MapIteratorToOriginalValue.hpp)
set(stlmaphelpers-HEADERS ${stlmaphelpers-HEADERS} ${HDR_DIRECTORY}/MapValueExtractor.hpp)
set(stlmaphelpers-HEADERS ${stlmaphelpers-HEADERS} ${HDR_DIRECTORY}/STLLikeIndex.hpp)

add_library(map-helpers-lib INTERFACE)
target_sources(map-helpers-lib INTERFACE ${stlmaphelpers-HEADERS})
target_include_directories(map-helpers-lib INTERFACE "${PROJECT_SOURCE_DIR}/include")
target_link_libraries(map-helpers-lib  INTERFACE content-helpers-lib)


Background
==========

Experimental HIV vaccines can elicit antibodies to HIV proteins expressed by the vaccine, leading to a positive HIV serologic test result without infection. Vaccine induced seropositivity (VISP) can cause social harms for trial participants and potentially threatens study validity by unblinding participants and staff. Trial participants are educated to avoid HIV testing outside the trial site until trial completion or disappearance of VISP, whichever occurs later. In 2006, the U.S. Centers for Disease Control and Prevention released guidelines recommending that HIV testing be performed as part of routine medical care without specific written consent, raising concern that trial participant education alone might be insufficient to avoid inadvertent HIV testing of trial participants in the community.

Methods
=======

The Seattle HIV Vaccine Trials Unit (HVTU), in collaboration with the HIV Vaccine Trialsshowing a lot of awareness for what is happening around him, while being trapped in his own ego at the same time. However, what impressed me about him was his constant disapproval and disgust for what people are capable of when they hurt one another. He is a physical example of using your powers for good. However, he also has a very weak and vulnerable state when it comes to love or The Witch of the Waste, which at times complicates things even more, but he eventually pulls through when he is needed (mostly because of Sophie and the courage she offers him).

This story goes through so many stages, so many beautiful t urns and twists, while the characters find one another but also in hope to change


import dill
import logging

class Transformer(object):
    def __init__(self):

        with open('/mnt/tfidf.model', 'rb') as model_file:
            self._tfidf_vectorizer = dill.load(model_file)

    def predict(self, X, feature_names):
        logging.warning(X)
        tfidf_sparse = self._tfidf_vectorizer.transform(X)
        tfidf_array = tfidf_sparse.toarray()
        logging.warning(tfidf_array)
        return tfidf_array

PHILADELPHIA — The expectation, or at very least the hope, was that it would have happened no matter where on the ice he was stationed.

Claude Giroux finally looks like Claude Giroux again.

He’s a left wing these days, instead of a natural center, and is back to being a point-per-game player. He has 20 points in 16 games. Last season it took him 24 games to reach that mark.

The Flyers captain had been in a statistical decline for three seasons and in only one of them could offseason surgery really be blamed. Sports hernia surgery claimed most of his campaign last year even though he didn’t miss time with injury. The same was true for Shayne Gostisbehere, who had a similar surgery on the same day.

They weren’t themselves. They


lives of all of us." "Question: what is the fate of a Bonapartist" "In these marching times?" "He's a..." "Bonapartist?" "On the way home, our ship put in at Elba." "The captain went ashore." "Two days later, before he died, he handed Dantes an envelope." " So?" " So use your imagination." "I'm suggesting that captain Leclere went ashore to consort with Napoleon Bonaparte himself." "I'm suggesting that" "Envelope contains secret orders." "I'm proposing that we take advantage of the possibilities in this situation." "Wake up." "Hey paper, ink!" "One moment monsieur." "Please, just a moment." "Edmond." "Yes, father." "I'm an old man without manners, but I must ask Miss Higgins a question." "What is it?" "That young lieutenant, your cousin, Fernand Mandego," "I'm told he loves you,"What is this?" "In simple terms, it means a quarter past 12 o'clock." "A clock." "A clock, a calendar, an astronomical chart." "Here, I will show you." "My book." "My....needle, made from a fishbone," "Like my chisel made from one of the irons in my bedstead," "Like my pincers, and my knife and my lamp." " A lamp needs oil." " Which I make from the suet from the meat they give us on holy days." "How do you light your lamp?" "Oh, I claim to have a skin disease." "I sometimes ask for sulphur." "To relieve the pain." "From which i replenish my match." "Haaa." "[ Gasping ]" "Um." "Now." "All this talent for my hope and salvation." "Now my dead hope." "Five years spent on a


in his face that was never there before." "Mondego." "Mondego!" "Vengeance belongs to the lord, Edmond." "Turn away from such unholy thoughts before they destroy you." "Caderousse!" "De Villefort!" "Danglers!" "[ Gasp ]" "Ummm." "[ Sigh ]" "Ummm." "[ Sigh ]" "Edmond." "Edmond." "Dear God, what is it?" "Edmond, Im ill." "[ Grunting ]" "I'm dying." "You must live." "I'll finish the tunnel, myself." "[ Gasp ] Edmond, [ gasp ], you must finish the tunnel and escape." "Find the treasure." "Treasure?" "A map." "Of the Island of Monte Cristo." "This is the lost map of Chezure's father, with who's death in 1498 vanished one of the great treasures of the world." "[ Gasp ] This fortune has been buried on monte cristo for" "Three and a halfcenturies." "Oh, Edmond, I wanted us to find this treasure together." "Now it is for you to find alone." "Do great charitable deeds with this." "[ Gasp ] spend this fortune, which God has been hoarding for you, in good and holy ways." "[ Gasp ] Edmond, you must escape and find the treasure." "My profession forbade me to marry, so you are my son, the child of my captivity." "Make thy works of goodness a memorial to me." "What is such treasure to me?" "My real treasure lies here." "You have enriched me beyond..." "Ah!" "Ohhhhhh!" "[ Slap ]" "[ Crying ]" "[ Jailor coming ]" "[ Cell window opens ]" "[ Breakfast ]" "[ Cell window closes ]" "Yeah, he's done all right." "The poor old


water?" "A, b, c, d, e, f, g [ blink ]" "G. Valois, he wants his glasses." "He's delighted to see you." "Are you not, Grandfather?" "What other man which do we need?" "Valois, is it time to start his meal?" "My grandfather is a prisoner of his body, monsieur." "But his will is like his mind, unconquerable." "He possesses what few men can boast of, the devotion of one loving heart." "That's a lonely statement, monsieur." "Monsieur Albert is here, mademoiselle." "Albert!" "Oh, monsieur, please." "I shall return immediately." "You must excuse me, sir, if I seem to stare." "It doesn't often happen that a man can gaze upon the one great nemesis of his life." "Don't strain for explanations, monsieur." "It is now my turn toknow his family, of course." "All of Italy knows the Cavalcante, who were rich when the Medici were peasant stock." "...Signorina, I would be deeply grateful..." "Your daughter's fiancé does not take exception?" "But, my daughter has no fiancé." "She's not engaged to Albert Mondego?" "Not at all." "Not at all." "They are only friends." "[ Door opens ]" "My dear count." "M. Danglars, I wish to purchase a newspaper, Le Journal de Globe," "I am told it's for sale." "I rather fancy owning a newspaper." "Please arrange for its purchase." "Very good, I approve, every man of affairs should own a newspaper." "Second, I wish to buy some Spanish government bonds." "In what amount of purchase, sir?" "One million." "I...in...uh..." "Spanish bonds?" "Can the purchase be effected


you..." "Contact our most important portfolio, sir, inform them" "De Livier, and...uh.." "Beaufort, that the house" "Of Danglars recommends heavy investment in Spanish bonds." "Well, do it!" " Now!" "[ Toasting ] the Count of Monte Cristo." "Is this your semaphore station?" "Mine?" "I work it." "I've done for many years, but I never have any visitors." "How does it work?" "There's another one on the far horizon." "That's my right-hand correspondent." "And there is my left hand." "When I receive a message, from right I transmit it to left." "thus, our messages from Spain transmitted all the way" "To Paris in a matter of hours." "A modern miracle." "Three thousand francs, five years pay, if you relay" "This message to Paris." "But...this is...not official." "You insult me,could buy up our bonds." "But, gentlemen, I've sold my bonds, too." "I swear it!" " You lie." " I don't believe you, Danglars." "Danglars, do you know what you have cost me?" "You've read the paper, haven't you?" "But, gentlemen, you've lost nothing..." "I lose when I do not make." "I want to know what this is all about." "I've made good every penny." "I demand to know." " I will take the matter up with the chamber." " The bonds on governments." " Confess, Danglars, confess, you are a scoundrel." " Be advised, Danglars," " I am taking you to court." " After me, I am taking him to court, first." " No, after me." "On charges of false representation." " Misusing of funds!" "Embezzlement." "


that." "Ask me to forgive him for stealing 14 years of my life." "Very well, forgiven." "But forgive him for destroying my father." "Never, madame." "Never!" "In my dreams I have seen you dead." "Thrown to the bottom of one of those pits where jailers throw their dead prisoners." "And I awake from this incessant dream with a cry, shuddering cold." "Have you ever dreamed your father dead of hunger?" "Have you ever dreamed of the one you loved giving her hand to a rival," "While you perish at the bottom of a pit." "What!" "I have seen him I loved on the point of murdering my son." "Oh, Edmond, please." "What good has it done for me to mourn for you eternally in the secret recesses ofmy heart?" "When I thought you dead, i should have died, too." "But foolishly I went on living, and for nearly 20 years compared all men to you and found them wanting." "Missing you has been a day after day, year after year torment to me." "And in all this time my one consolation has been my son." "My innocent son who should have been ours." "Our son, Edmond." "Ready." "1, 2, 3, 4, 5, 6, 7, 8, 9, 10" "[ Gunshot ]" "[ Gunshot ]" "She told you." "Everything." "I offer you my apologies, sir." "You have every right to expose my father." "Providence, again." "I am the emissary of God." "I've been spared to carry out his will." "General Mondego," "This special committee of the house


of the utmost confidence." "So complete was his faith in me, that on his deathbed he resigned his wife and daughter to my care." "His wife and daughter." "What happened to that wife and daughter?" "I searched for them, M. le President, in the midst of the battle." "My life was in constant danger, but I searched for them until I found them." "They had been slaughtered by the enemy." "Can you produce testaments to the truth of what you have asserted?" "Monsieur le President, if the signed proof of Ali Pasha is not enough," "I offer my word of honor as a french officer." "Last, but not least, this." "You ask for witnesses of proof, I ask for a show of witnesses against me." "What is theukey[0] = digest_saved[0];
  ukey[1] = digest_saved[1];
  ukey[2] = digest_saved[2];
  ukey[3] = digest_saved[3];

  u32 ks[60];

  AES128_set_decrypt_key (ks, ukey, s_te0, s_te1, s_te2, s_te3, s_td0, s_td1, s_td2, s_td3);

  u32 verifier[4];

  verifier[0] = esalt_bufs[digests_offset].encryptedVerifier[0];
  verifier[1] = esalt_bufs[digests_offset].encryptedVerifier[1];
  verifier[2] = esalt_bufs[digests_offset].encryptedVerifier[2];
  verifier[3] = esalt_bufs[digests_offset].encryptedVerifier[3];

  u32 data[4];

  data[0] = verifier[0];
  data[1] = verifier[1];
  data[2] = verifier[2];
  data[3] = verifier[3];

  u32 out[4];

  AES128_decrypt (ks, data, out, s_td0, s_td1, s_td2, s_td3, s_td4);

  // do a sha1 of the result

  w0[0] = out[0];
  w0[1] = out[1];
  w0[2] = out[2];
  w0[3] = out[3];
  w1[0] = 0;
  w1[1] = 0;
  w1[2] = 0;
  w1[3] = 0;
  w2[0] = 0;
  w2[1] =


w3[1] = 0;
  w3[2] = 0;
  w3[3] = 0;

  sha1_init (&ctx);

  sha1_update_64 (&ctx, w0, w1, w2, w3, 16);

  sha1_final (&ctx);

  // encrypt it again for verify

  AES256_set_encrypt_key (ks, ukey, s_te0, s_te1, s_te2, s_te3);

  data[0] = ctx.h[0];
  data[1] = ctx.h[1];
  data[2] = ctx.h[2];
  data[3] = ctx.h[3];

  AES256_encrypt (ks, data, out, s_te0, s_te1, s_te2, s_te3, s_te4);

  {
    const u32 r0 = out[0];
    const u32 r1 = out[1];
    const u32 r2 = out[2];
    const u32 r3 = out[3];

    #define il_pos 0

    #ifdef KERNEL_STATIC
    #include COMPARE_M
    #endif
  }
}
fact the exact value of the persistent exponent for arbitrary $\s>0$.

Let us formally introduce our model: We consider coarsening of the 1D 2-state spin system with a long-range ferromagnetic Hamiltonian: $$H = {-4\over\s}\sum_{i > j}{s_is_j \over {(x_i-x_j)}^{\s+1}}.$$ After quenching from a high-temperature random phase to $T=0$, coarsening dynamics for this system is determined by the motion of domain walls, governed by the Langevin equation. The velocity of a wall is equal to the sum of pairwise forces from other walls, with walls of the same signs repelling and walls of the opposite signs attracting each other: $$\label{f}
{d r_i \over dt} = \sum_{j \neq i} {(-1)}^{i+j}
{\mathrm sign}(r_i-r_j) F_{ij}$$ $$F_{ij} = {1 \over {|r_i-r_j|}^{\s}}.$$ When the adjacent walls meet, they annihilate. As we mentioned, the degree of coarsening is uniquely


characterized by a typical domain size $L(t)\sim t^{1/(1+\s)}$. We measure the fraction of space $P(L)$ that has never been crossed by a single domain wall as a function of this lengthscale $L(t)$. We perform molecular dynamics simulations of the model for the following values of the force exponent: $\s=3/2,\: 5/4,\: 1,\: 3/4,\: 1/2,\: 1/4$. Each run starts with a system consisting of $N_0= 100000$ domain walls; results for each $\s$ are averaged over 20 initial configurations. Open boundary conditions with no replicas added to the boundaries are used. To speed up the evaluation of forces, a 1D multipole expansion has been performed, and terms of up to quadrupole order were taken into account [@ik].

[. The log-log plot of persistence $P(L)$ vs. average domain size $L$ for various forceSteven T. Byington

Steven Tracy Byington (birthname Stephen) (December 10, 1869 – October 12, 1957) was a noted intellectual, translator, and American individualist anarchist. He was born in Westford, Vermont, and later moved to Ballardvale section of Andover, Massachusetts. A one-time proponent of Georgist minarchism, he converted to individualist anarchism after associating with Benjamin Tucker. He was a firm believer in the promotion of individualist anarchism through education. He said "Anarchism has undertaken to change men's minds in one point by removing their faith in force" (Quasi-Invasion and the Boycott in Liberty, X, 2). He began a "Letter Writing Corps" in 1894 which targeted specific individuals, including newspapers, to familiarize others with the philosophical doctrine. He is known for translating two important anarchist works into English from German: Max


the summary judgment.  Neither USAIG nor the district court addressed this theory of Royal's claim.  See id., at 159-60, 90 S.Ct. at 1609-10, 26 L.Ed.2d at 155-156.  Although Royal may not have a claim under the Texas Deceptive Trade Practices Act, Tex.Bus. & Com.Code Ann. Secs. 17.41-17.63 (Vernon Supp.1985), see Rosell v. Farmers Texas County Mutual Insurance Co., 642 S.W.2d 278, 279 (Tex.App.--Texarkana 1982, no writ) (additional insured is not "consumer" entitled to bring action under Texas Deceptive Trade Practices Act), Royal may have a cause of action under Tex.Ins.Code Ann. art. 21.21, Secs. 4, 16 (Vernon 1981), see Hi-Line Electric Co. v. Travelers Insurance Co., 593 S.W.2d 953, 954 (Tex.1980) (indicating that nonconsumers injured by deceptive trade practices have cause of action under Insurance// Copyright 2015 The Go Authors. All rights reserved.
// Use of this source code is governed by a BSD-style
// license that can be found in the LICENSE file.

package unix

import (
	"syscall"
	"unsafe"
)

func setTimespec(sec, nsec int64) Timespec {
	return Timespec{Sec: int32(sec), Nsec: int32(nsec)}
}

func setTimeval(sec, usec int64) Timeval {
	return Timeval{Sec: int32(sec), Usec: int32(usec)}
}

//sysnb	gettimeofday(tp *Timeval) (sec int32, usec int32, err error)
func Gettimeofday(tv *Timeval) (err error) {
	// The tv passed to gettimeofday must be non-nil
	// but is otherwise unused. The answers come back
	// in the two registers.
	sec, usec, err := gettimeofday(tv)
	tv.Sec = int32(sec)
	tv.Usec = int32(usec)
	return err
}

func SetKevent(k *Kevent_t, fd, mode, flags int) {
	k.Ident = uint32(fd)
	k.Filter = int16(mode)
	k.Flags = uint16(flags)
}

func (iov *Iovec) SetLen(length int) {
	iov.Len = uint32(length)
}

func (msghdr *Msghdr) SetControllen(length int) {
	msghdr.Controllen = uint32(length)
}

func (cmsg *Cmsghdr) SetLen(length int) {
	cmsg.Len = uint32(length)
}

func sendfile(outfd int, infd int, offset


is a need for an edge breather that eliminates the need for consumable breather materials while providing a relatively large and consistent volume of space around the edges of the layup that may aid in evacuating air and volatiles from the layup during curing.Since 9/11 American’s have been giving up their liberties. Most of the time it’s because they have been told it is necessary for their ‘safety’. Conservatives yell “socialism” at anything the President suggests, but I don’t hear anyone yelling ‘Fascism” at his lack of support for our rights or his active support for taking away those rights (Patriot Act, Domestic Spying/Eavesdropping, punishing whistleblowers, etc.). The biggest criminals in the world get away with slaps on the wrist while the least powerful have less rights then ever before.

I still remember Eisenhower’s warning:

Up through World War II war-profiteering was punishable by death. Today we have Haliburto/Cheney, Blackwater-Xi/Prince, and they are immune, supported by our legislators.

An LAPD officer would forcibly extend the protestor’s legs, grab his left foot, twist it all


Von der Heydt is able to bridge the emotional gap, find ways to become more approachable and build loving and trusting relationships with the children.

Social worker Amy von der Heydt along with her therapy dog Molly join us for more on the benefits of using therapy dogs with children.a world in which virtual communication is now the standard, face-to-face interactions come at a premium. Eighty per cent of those I have surveyed prefer spending time with their friends in person rather than on the phone or online.

But authenticity and connection are not the only the only concepts at a premium. Members of Generation K increasingly value things they can actively co-create. It is a generation of makers, creators and inventors. From Sarah, who builds her own computers, to Jake, who loves making horror films with his pals on his iPhone, today’s teenagers don’t only want to buy stuff, they want to imprint their voice on products, services and media, and become part of the design and creation process. Producing something themselves has value for this generation.


A substantial portion 38.9% (95% CI: 19.0%-79.0%) of the association between weight-based discrimination and medication non-adherence was mediated by medication self-efficacy. Self-efficacy is a potential explanatory factor for the association between reported weight-based discrimination and medication non-adherence. Future research should develop and test interventions to prevent weight-based discrimination at the societal, provider, and institutional levels.WarmlyYours Deicing System Provides Amputee Troops Safety, Support

Written by Heather YoungPosted on 04/02/2014

Most of us will never understand what it takes to return to civilian life after the traumatic injuries — including amputations —suffered by many of our troops while serving our country. After experiencing firsthand the struggle of troops overseas, Jim Peters took action, founding Tee Shirts 4 Troops, an organization committed to supporting recovering troops in a multitude of ways — providing them with everything from clean, uplifting, superhero-emblazoned tee shirts to wear during their hospital recovery to the rehabilitation services, coaching, and housing they need as they reenter civilian life.

Everything Tee Shirts 4 Troops does is donation driven. It gives away tee shirts (14,500+ to date), offers music instruments (175+ to date) and lessons (which


melting system on the front steps give us peace of mind. We never know who and when and what is coming to the door in the form of the wounded — whether they have all of their limbs or none. If you are missing a leg you can’t feel the snow, and if you are a double amputee, you can literally ski out the door without those systems in place,” Peters shared. “It was a huge assist for us and the amputees.”

The system was installed in under four hours by a handyman with one assistant. “It was the first time he installed that product, but he did it flawlessly with just a few questions to WarmlyYours’ customer service department in the beginning of the project. It is awould be the spitting image of Elvis.

Even Lisa Marie admits that she is regularly shocked and overwhelmed by how much her son looks like her late father did.

“He was at the Opry behind the stage. Everybody turned around and looked when he was over there. Everybody was grabbing him for a photo because it is just uncanny,” Lisa Marie told CMT in an interview in 2012.

But much like his mother in recent years, Benjamin prefers to keep himself out of the public eye and away from the flash of the cameras.

Lisa Marie has made it very clear that she will support her son in anything he chooses to do.

Unfortunately, during his childhood he was often dragged into the limelight through his mother's various marriages. She even married Michael


The Dragon of Dojima has affected many lives over the course of the Yakuza Series. Three new live-action shorts revisit just a few of them.

For longtime fans of the Yakuza series, Kazuma Kiryu has always represented justice and strength. He’s a good man who never says no to those in need and his willingness to take decisive action brings out the dragon in all of us. It’s ironic that a man like this would come from a criminal organization – but that, of course, reminds us of the goodness in people.

To celebrate the release of Yakuza 6: The Song of Life, we partnered with Liquid Advertising’s creative team and director Christopher Ewing to explore the legend of the Dragon of Dojima from an unexpected point of view –home.

Yuina, a respected club owner, deals with an unruly customer as she recalls the time she met Kiryu.

Haruka takes us back in time through the streets and playgrounds of the neighborhood she grew up in.

To create an authentic sense of place, we filmed each of their stories on location in Japan, capturing the unique light, grit, and beauty of the world that has captivated fans of the series for over a decade. Together, these recollections give us a new look at the legend of Kazuma Kiryu, as those who live in his world see him – a kind and strong protector who will always answer a cry for help.


devices in Europe and Asia. The MindMaze platform will become more broadly available through licensing in the business-to-business and business-to-consumer spaces to power virtual reality-optimized products for mainstream experiences beyond gaming,” reads the press release.

This article may contain affiliate links. If you click an affiliate link and buy a product we may receive a small commission which helps support the publication. See here for more information.

This article BEGS for more investigation. This sounds like a scam company whose fleecing investors. I’ve messed around with a few consumer brain sensors, and they, at most, can tell you if you’re irritated. Even the best medical ones only read vague, general areas. They do NOT put vision or sound into your head. This is not going to plug you into theexperience, but Fortune goes into a little bit more detail on the front:

“The system combines self-teaching artificial intelligence with computer vision in a way that can be customized to the patient’s needs and provide real-time multisensory feedback on the patient’s progress or lack thereof”. An article from Bloomberg last May notes that in a “20-person clinical trial, patients using the equipment two and a half hours a day for three weeks improved their motor function by as much as 35 percent”. It’s not cheap stuff either; $80,000 to purchase, or $2,500/month for rent – these are numbers that certainly would cause some consideration on the part of buyers before purchase – not to say that people haven’t been swindled before. It wasn’t too long ago that VR itself


a - q. What is y rounded to the nearest ten thousand?
-480000
Let b = -9767.2 - -12685. Round b to the nearest 1000.
3000
Let l = -0.0697 + 0.0361. Let m = 0.02838 + l. Round m to 4 dps.
-0.0052
Let n(i) = 305581*i**3 + 5*i**2 - 4*i + 5. Let w be n(3). Let x = w - 11779877. Let c = -12229152 - x. What is c rounded to the nearest 1000000?
-9000000
Let s = 3430.0003822 + -3430. Round s to 4 dps.
0.0004
Let a(y) = -3134000*y. Let f be (-1 + -14)*(-1)/3. Let l be a(f). What is l rounded to the nearest 1000000?
-16000000
Let a = -294.955 + 207.76. Let q = 87 + a. Let h = q + 0.1432. What is h rounded to 3 dps?
-0.052
Let afor the disease. The approach we have devised for identifying resilience factors is straightforward yet, to our knowledge, unprecedented. We identify unaffected individuals at the highest levels of multivariate risk, match them to affected individuals at equivalent levels of risk, and contrast these two subgroups to find residual variation associated with the absence of disease. In this project, we will capitalize on the wealth of existing high-throughput AD risk-factor results and data, and our involvement in many of the world?s largest AD consortia, to efficiently map resilience to AD at three levels (genetics, transcriptomics, and neuroimaging), and to integrate across these levels. In Aim 1, we will identify genetic variation associated with resilience to AD in the presence of elevated genetic risk conferred by APOE ?4 alleles, an


Q:

Can't modify instagram font awesome tooltip

I have the following code:

It generates the following icon:

But I want to create a similar icon instead:

I have tried modifying the part below but it won't work.

Any suggestion on how to continue?

A:

The one you have in font-awesome at a better view also, it shows this way:

This is not available until you use an image or SVG for this. If the issue is about the background colour, please give:
.instagram {
  backgroud: #99f;
  padding: 5px;
  display: inline-block;
}

Using SVG:

a {background: #99f; padding: 5px; width: 32px; height: 32px; border-radius: 100%; margin: 15px;}
a, img, svg {display: block; width: 32px; height: 32px;}
a svg path, a svg d {color:the physical, legal, psychological, and societal consequences of their actions or inactions.

It is our duty to make you aware of certain unpleasant physical realities intrinsic to the Planet Earth. Mr. Farnam is happy to be your counselor and advisor. Visit: www.defense-training.com


Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis.
To report a case of long-standing atopic dermatitis and atopic keratoconjunctivitis (AKC) with associated pellucid marginal corneal degeneration (PMCD). Noninterventional case report. A 45-year-old man presented with the complaints of frequent change in glass prescriptions over the past 5 years. Erythema, dryness, and scaling were noted over both eyelids and the face. An area of inferior peripheral corneal thinning with ectasia of the normal cornea above it was present. Corneal topography showed the presence of against-the-rule astigmatism with inferior sagging of the horizontal semi-meridians, in both the eyes. The patient was prescribed treatment for AKC and blepharitis and was advised against eye rubbing. Eye rubbing seen in atopic ocular conditions like AKC may be a contributory factor in the     if (existingOrdinals.contains(newOrdinal))
        {
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        }
        else
        {
            existingOrdinals.add(newOrdinal);
            return true;
        }
    }

    /**
     * Validated the values of the enum.
     */
    @Test public void testCommentTypeValues()
    {
        existingOrdinals


  {
        ObjectMapper objectMapper = new ObjectMapper();
        String       jsonString   = null;

        try
        {
            jsonString = objectMapper.writeValueAsString(CommentType.ANSWER);
        }
        catch (Throwable  exc)
        {
            assertTrue(false, "Exception: " + exc.getMessage());
        }

        try
     steeper slopes can be quite challenging in the beginning. If the resort is closed do not to go when they prepare slopes with groomers, steel ropes can be a serious hazard during slope prep works. Also check if they allow slope touring and do not destroy freshly groomed slopes because the next day your tracks might be frozen what resort operators do not like.

There is no need to be ashamed of going up a ski slope with switched on beacon, shovel, probe and the rest of the equipment. On the contrary, this is how you learn to optimize your equipment and internalize standard procedures such as turning the transceiver on and off after the tour or to check your partners.

Visit mountaineering camps that not solely focus on avy


more experience. Navigating in white out conditions can be very difficult, baking down if the visibility decreases is highly recommended

Take decisions together, oriented on the weakest group member

Always be defensive. Better say no when in doubt. Mountains usually don’t run away so there is always a second and third opportunity on another day or in another season.

Don’t focus on a single ambitious goal. Just be grateful for being in the mountains and don’t strive for perfection. There is always another peak, line, ridge or slope that can be ridden.

Don`t trust solely on digital devices, always take a traditional map and an analog compass

Here you find a quite interesting article about tour planning with further info: https://www.splitboarding.eu/en/safety/trip-planning

Literature

Werner Munter: 3x3 Lawinen: Risikomanagement im Wintersport. Tappeiner, 5. Auflage, 2013, ISBN: 978-8870737752

RudiQ:

LaTeX formatting in Word using Rmarkdown and flextable

I have a table that contains column headers with LaTeX formatting (e.g., Lower CI$_{95\\%}$). When I render the table in HTML or PDF format using knitr::kable, they display the correct formatting, but prints verbatim using flextable::regulartable.
Does flextable::regulartable not handle LaTeX, or am I missing the argument (e.g., escape = T) to specify LaTeX? And if it's not supported, will it be eventually?
It works in pander, but flextable provides much better formatting options (aside from the apparent lack of LaTeX support).

A:

Flextable is designed to output using Word's bespoke xml formatting. It is not designed to interpret LaTeX formatting, so you've not missed out arguments which would turn this functionality on or off.
The package and the officeR package


it. Thirty years after Spain was first shocked to find the body of a migrant washed up on its shores, and scarcely six weeks after the new government took in 630 people on the rescue ship Aquarius who had been turned away by Italy and Malta, some rightwing politicians have begun to talk of identity papers, more border controls and “millions of Africans” wanting to come to Europe.

In a country that has traditionally been pro-immigration and devoid of a significant far-right party since its return to democracy, their words have raised eyebrows and concerns. “The first thing we need to be clear about is that there’s a bit of unwarranted alarm over the arrivals we’ve seen over the past month,” said Villahoz, president of Algeciras Acoge, the localcranes, palm trees and occasional German or Chinese tourists. Most of the new arrivals are taken straight to the sports centres that have been pressed into service as makeshift police stations and then sent elsewhere in the province.

Nor, for the moment, is there any evidence of a curdling of sympathy among Andalucians, who are well used to the summer’s habitual human cargo. “We’ve had more arrivals than ever this year, about 2,500 so far,” said Miguel Molina, mayor of the town of Barbate, an hour’s drive west of Algeciras. “That’s not a Lampedusa is it? That’s an exaggeration. There’s an increase on other years but the people of Barbate are, as ever, showing their solidarity with these people who’ve made long journeys, some of which have lasted years.”

But


Ramratan Kushwaha is BJP lawmaker from Lalitpur (File)

A BJP legislator advised party workers to hit government officials with shoes if they don't accord respect. He also issued a threat to officials who, he said, were inclined to the Samajwadi Party and the Bahujan Samaj Party's ideologies, saying they should be wary of him.

"If government employees don't respect our workers, then take off your shoes and hit them because there is a limit to patience," Ramratan Kushwaha, Lalitpur legislator, was quoted by news agency ANI as saying.

The BJP leader was addressing a gathering of party workers when he made the comment.

He alleged their were bureaucrats and police officials who misbehaved with party workers.

#WATCH: Ramratan Kushwaha, BJP MLA from Lalitpur at a party event says,"If government employees don't respect ourQ:

How would I optimize a nested for loop with linq

How would i write this with linq?
foreach (var to in allCurrentTradeObjects)
{
    foreach (var ro in theseWantMe)
    {
        if (ro.Type != to.Type
                || ro.MaxRent < to.Rent
                || ro.MinRooms > to.Rooms
                || ro.MinSquareMeters > to.SquareMeters
                || ro.MaxPrice < to.Price


lasers which extends the strengths of the two complementary approaches.

In Sec. II we describe the $\bm{k{\cdot}p}$ method to evaluate the electronic structure of (In,Ga)N QW which is used in Sec. III to calculate microscopic spin-dependent optical gain. In Sec. IV we combine these microscopic gain calculations with simple rate equations, suitable to describe various dynamical phenomena in spin lasers. In Sec. V we discuss future opportunities to apply our theoretical framework to other systems.

II. Quantum well electronic structure {#sec:QW_bs}
=====================================

An important consequence of the atomic arrangement of WZ materials along the \[0001\] direction is the presence of the polarization fields. A relative displacement between cations and anions in the unit cell leads to the spontaneous polarization along the growth direction in QWs. Under external applied strain this cation-anion displacement is modified and alsocalculated from the band structure in (a). The up and down labels refer to spin. The CB DOS is multiplied by a factor of 10 to match the VB scale. The band gap is $E_g=2.963\; \textrm{eV}$ (CB1-HH1 energy difference).[]{data-label="fig:bs_dos"}](fig2WZ.eps)

For the gain region of the laser we consider a 3 nm thick single strained $\textrm{In}_{0.1}\textrm{Ga}_{0.9}\textrm{N}$ QW, surrounded by 6 nm GaN barriers, the typical lengths and composition of (In,Ga)N-based vertical cavity surface emitting lasers (VCSELs) [@Lu2008:APL; @Lu2010:APL; @Kasahara2011:APE; @Lin2014:LPL]. The bulk InN and GaN parameters are obtained from Ref. [@Miao2012:PRL], we use their linear interpolation for the alloy $\textrm{In}_{0.1}\textrm{Ga}_{0.9}\textrm{N}$ and the bowing parameter for the band gap, $E_g$ [@Vurgaftman2001:JAP]. The interface band offsets are $\Delta E_C = 0.7\Delta E_g$ and $\Delta E_V = 0.3\Delta E_g$ [@Dong2013:JAP]. We choose $E_g$ at T = 300


K with Varshni parameters and the refractive indexes from Refs. [@Vurgaftman2001:JAP; @note:web].

To develop some intuition about the relevant SOC parameters in (In,Ga)N QWs, we recall that in GaAs, as the representative ZB semiconductor, at the $\Gamma$-point HH and LH are degenerate and separated by $\Delta_{SO} = 0.341$ eV [@Vurgaftman2001:JAP] from the SO band. It is helpful to think of ZB GaAs as a WZ structure without crystal-field splitting energy ($\Delta_1 = 0$) and a much larger SOC that yields $\Delta_2 = \Delta_3 = \Delta_{SO}/3 \approx 114 \; \textrm{meV}$ [@Park2000:JAP; @FariaJunior2012:JAP]. For the GaN barrier, $\Delta_1 = 10 \; \textrm{meV}$ and $\Delta_2 = \Delta_3 = 5.7 \; \textrm{meV}$, and for the QW material $\textrm{In}_{0.1}\textrm{Ga}_{0.9}\textrm{N}$, $\Delta_1 = 13 \; \textrm{meV}$ and $\Delta_2 = \Delta_3 = 5.3 \; \textrm{meV}$. In the bulk case, sucha gain spectra as function of photon energy for various carrier densities.

For calculated gain spectra in (In,Ga)N QWs it is customary to include various broadening effects. In addition to the homogeneous broadening, frequently used in ZB QWs [@Chow:1999; @FariaJunior2015:PRB], parametrized here by $sech$ with 10 meV full width at half-maximum (FWHM), we also consider an inhomogeneous Gaussian broadening, attributed to compositional and potential fluctuations. Our choice of Gaussian broadening with 20 meV FWHM is consistent with a decreased broadening for smaller emission wavelengths in (In,Ga)N QW lasers and reported values relevant for wavelengths of $\sim$415 nm [@Funato2013:APE] which corresponds to the typical energy of the gain peak in our calculations.

Because of the broadening effects, the individual CB1-HH1 and CB1-LH1 transitions that dominate the gain spectra cannot be distinguished \[HH1 and


the sign change of $g_\text{asy}$ and its maximum magnitude in the $g<0$ regime for the larges shown carrier density. This behavior points to yet unexplored opportunities to optimize the operation of spin lasers with a simultaneous spin polarization of electrons and holes.

Our results show that despite the small SOC energy of WZ nitrides, considered detrimental for optical spin injection, the gain asymmetry remains robust. Another important figure of merit of spin lasers is their threshold reduction, the lasing operation could be attained at lower injected carrier density than in conventional lasers. We will analyze this behavior in the next section.

IV. Rate equations {#sec:RE}
==================

Here we briefly review a complementary approach based on rate equations (REs) and discuss how its understanding can be enhanced from our microscopic gain calculations. REsPhys. [**112**]{}, 103716 (2012).

M. S. Miao, Q. Yan, C. G. Van de Walle, W. K. Lou, L. L. Li, and K. Chang, Phys. Rev. Lett. [**109**]{}, 186803 (2012).

P. E. Faria Junior, T. Campos, and G. M. Sipahi, J. Appl. Phys. [**116**]{}, 193501 (2014).

G. M. Sipahi, R. Enderlein, L. M. R. Scolfaro and J. R. Leite, Phys. Rev. B [**53**]{}, 9930 (1996).

T.-C. Lu, C.-C. Kao, H.-C. Kuo, G.-S. Huang and S.-C. Wang, Appl. Phys. Lett. [**92**]{}, 141102 (2008).

T.-C. Lu, S.-W. Chen, T.-T. Wu, P.-M. Tu, C.-K. Chen, C.-H. Chen, Z.-Y. Li, H.-C. Kuo and S.-C. Wang, Appl. Phys. Lett. [**97**]{}, 071114 (2010).

D. Kasahara, D. Morita, T. Kosugi, K. Nakagawa, J. Kawamata, Y. Higuchi, H. Matsumura and T. Mukai, Appl. Phys. Expr. [**4**]{}, 072103 (2011).

B. C. Lin, Y. A. Chang, K. J. Chen, C. H. Chiu, Z. Y. Li, Y. P. Lan, C. C. Lin, P. T. Lee, Y. K.


of Semiconductors*]{}, 4$^\textrm{th}$ Edition (World Scientific Publishing, Singapore, 2004).

W. W. Chow and S. W. Koch, [*Semiconductor-Laser Fundamentals: Physics of the Gain Materials*]{}, (Springer, New York, 1999).

M. Funato, Y. S. Kim, Y. Ochi, A. Kaneta, Y. Kawakami, T. Miyoshi and S. Nagahama, Appl. Phys. Express [**6**]{}, 122704 (2013).

C. Brimont, M. Gallart, A. Gadalla, Olivier Crégut, Bernd Hönerlage, and P. Gilliot, J. Appl. Phys. [**105**]{}, 023502 (2009).

, edited by R. Michalzik (Springer, Berlin, 2013).

L. A. Coldren, S. W. Corzine, and M. L. Mašović, [*Diode Lasers and Photonic Integrated Circuits,*]{} 2$^\textrm{nd}$ Edition (Wiley, Hoboken, 2012).

I. Žutić, R. Oszwałdowski, C. Gøthgen, and J. Lee, Semiconductor Spin-Lasers, in Handbook of Spin Transport and Magnetism, edited by E. Y. Tsymbal and I. Žutić (CRC Press/Taylor&Francis, New York, 2011), pp. 731-746.

I. Žutić, J. Fabian, and S. Das Sarma, Appl. Phys. Lett.reward for their support.
University Housing has jumped on board to help involvement in the
GC Residence Halls as well.”

Fans without smartphones will also be eligible by signing up at
the marketing table at athletic contests. The Bobcat Fan Rewards
program also has an up-to-the-minute leaderboard, so all members of
Bobcat Nation can compete to be the top Bobcat fan for 2012-13.

The QR Code signup will be available on all Bobcat schedule
posters and magnets, and also at Georgia College Athletic
contests.

The LOYALTIVA platform is created to incentivize most all fan
interactions with a team - such as attendance, concessions,
merchandise, donations, ticket renewals, viewing of Internet game
broadcasts, sponsor patronage, etc. Rojo Reseach provides fan
consumer behavior data for over 100 college and professional sports
organizations throughout the U.S. and Canada.


governments need to find and implement new programs to help reduce the number of families struggling to make ends meet when it comes to putting healthy food on the table.

"We really need to be able to do something about it because it does impact long-term health. It just makes sense to invest in strong social policy that will get those numbers down."

Williams said people are starting to take action, and there's lots of work being done in communities across Nova Scotia to help people get the food they need.

"People are becoming very concerned about this and taking action and there are things people can do in their communities to try and improve access to food."civilian at 19. Number of injured civilians have gone up drastically on Friday. Over 3600 people were injured since militant Burhwan Wani was killed on July 8.

Hospital sources said three youths received bullet injuries when the Army allegedly opened fire in Kupwara district’s Gushe area following an anti-India procession after Friday prayers. Hundreds of protesters attacked the boundary wall of the Army’s 62 Rashtriya Rifles camp in Chodergund area of Shopian district. Aerial firing forced the protesters to leave the area.

At least nine youths were injured in clashes in parts of Srinagar. Three of the injured were admitted in Srinagar hospitals from Pulwama, Shopian and Baramulla districts. Scores were injured when the police burst teargas shells to disperse a group of people marching towards the U.N. office in


Stories

Southern Cooking: Wilmington’s Favorite Iconic North Carolina Foods

Do you have a favorite North Carolina food, an iconic dish that was passed down from kitchen to kitchen? What would you tell a Wilmington visitor that should order for a real taste of the Port City? Share it in the comments below!very historic and very famous 1-2 victory in the 200 miles race of Imola in 1972. This historic photo was taken on the 23rd of May 1972, moments after they were given the winners trophy! Note the finish flag on Paul Smart’s winning bike, this flag was actually used when he crossed the finish line as the winner!

On the Ducati with number 9 we see Bruno Spaggiari. In the middle, accepting the well deserved trophy, we see the famous designer of the winning Ducati: Fabio Taglioni. A man that needs no further introduction. Right, on the Ducati with the finish-flag draped over the fairing, we see racewinner Paul Smart.

That day a crowd of 70,000 people saw Paul Smart on Ducati win the heavily battled 200 miles race of


from the relentless and dogmatic reliance on targets, Performance Indicators and league tables which drives the public sector in ways which make it look good rather than improve things for us.

Take 2 examples. Try booking a Doctor's appointment a few days in advance. You can't ? That'll be down to the targets they have to hit.

Racial incidents reported to the council ? you would have thought the fewer the number the better for all of us - a signal that we are living in a more tolerant society perhaps. Oh no, Councils are set targets to increase these each year. The result ? Council staff and community safety officers manipulating reported incidents to exaggerate any racial aspect of it so to "improve" their performance year-on-year.

The most important case,Lots Available

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James. Last year, both Bloomberg and the LA Times criticized James for using his company like a personal piggy bank — leasing the company his own private jet at a rate of $3,276 per flight hour and contracting with his brother’s restaurant for $600,000 for catering services. In 2018, James had to apologize for comments that his employees said alienated women and people of color. At the time, A Domo spokesperson told Business Insider, “Anyone who knows Josh knows he cares deeply about creating a workplace where the best talent — regardless of their gender, race, religion, sexual orientation, age, or any other factor, feels welcome.”

Newman’s own history is also complicated. Newman started his first company HireVue at 20 after graduating early with a BA in International Businessof greenscreen equipment and plywood, there’s one bit of info we could discern:

Half-hidden under that tarp is a Starfleet escape pod from the Enterprise, as featured in the BEYOND trailer!

The orange-tipped rhombus which carries the Enterprise crew down to the alien planet has been spotted several times so far, with both Kirk and Sulu escaping the ship inside one, Chekov already landed, and an alien Starfleet crewmember emerging after touchdown.

While we can’t know the full details of the extra photography from this one photo alone, it seems likely that the descent from the Enterprise is one of the featured sequences that needed a few extra touches this month.


 \left(\vec{\epsilon}_1\times\vec{\epsilon}_3^{\dag}\right)
            \cdot\left(\vec{\epsilon}_2^{d}\times\vec{\epsilon}_4^{b\dag}\right)
            \nabla^2Y(\Lambda,m_{\pi},\vec{r})\nonumber\\
            &&+\frac{1}{3}S\left(\hat{r},\vec{\epsilon}_1\times\vec{\epsilon}_3^{\dag},
            \vec{\epsilon}_2^{d}\times\vec{\epsilon}_4^{b\dag}\right)
            r\frac{\partial}{\partial r}\frac{1}{r}\frac{\partial}{\partial r}Y(\Lambda,m_{\pi},\vec{r})\Big\}.\end{aligned}$$ In the above expressions, $S(\hat{r},\vec{x},\vec{y})=
3(\hat{r}\cdot\vec{x})(\hat{r}\cdot\vec{y})-\vec{x}\cdot\vec{y}$, and $$\begin{aligned}
Y(\Lambda,m,{r}) &=&\frac{1}{4\pi r}(e^{-mr}-e^{-\Lambda
r})-\frac{\Lambda^2-m^2}{8\pi \Lambda}e^{-\Lambda r}.\label{yy}\end{aligned}$$

To obtain the total effective potentials of the $\Sigma_c\bar{M}^*$ and $\Sigma_c^*\bar{M}^*$ systems, the effective potentials in Eqs. (\[sub01\])-(\[sub04\]) should be sandwiched between the flavor wave functions. Thus, the general total effective potential for different systems can be expressed as $$\begin{aligned}
V_{\text{total}}^{\Sigma_c\bar{M}^*} &=&
          \mathcal{G}\mathcal{V}^{\Sigma_c\bar{M}^*\rightarrow \Sigma_c\bar{M}^*}_{\pi}(\vec{r}),\label{totalv1}\\
V_{\text{total}}^{\Sigma_c^*\bar{M}^*} &=&
    -\frac{1}{2m_2}\nabla_1^2\right),\\
K_{\Sigma_c^*\bar{M}^*}^{J=3/2} &=& \text{diag}
                   \Bigg(-\frac{1}{2m_2}\nabla^2, -\frac{1}{2m_2}\nabla_1^2,
                   -\frac{1}{2m_2}\nabla_1^2, -\frac{1}{2m_2}\nabla_1^2\Bigg)\end{aligned}$$ with $\nabla^2 = \frac{1}{r^2}\frac{\partial}{\partial
r}r^2\frac{\partial}{\partial r}$ and $\nabla_1^2 = \nabla^2-6/r^2$, where $m_1$ and $m_2$ are the reduced masses of the $\Sigma_c\bar{M}^*$ and $\Sigma_c^*\bar{M}^*$ system, respectively.

$P_c(4380)$ and $P_c(4450)$
---------------------------

In Ref. [@Chen:2015loa], the authors considered the S-wave contribution only and obtained the bound solutions for the systems $\Sigma_c\bar{D}^*$ with $(I=1/2, J^P=3/2^-)$ and $\Sigma_c^*\bar{D}^*$ with $(I=1/2, J^P=5/2^-)$, which may correspond to $P_c(4380)$ and $P_c(4450)$, respectively. In this work, we include the S-D mixing and restudy these systems. The numerical results for the $\Sigma_c\bar{D}^*$ system with $(I=1/2, J^P=3/2^-)$


masses of $P_c(4380)$ and $P_c(4450)$. After comparing the results with and without the S-D mixing effect, we find that the cutoff values become smaller with the S-D mixing effect. In other words, the S-D mixing effect is indeed helpful to the formation of these bound states.

We also notice that there exists slight difference of the fitted $\Lambda$ values for the $\Sigma_c\bar{D}^*$ and $\Sigma_c^*\bar{D}^*$, which are used to reproduce the central values of masses of $P_c(4380)$ and $P_c(4450)$. If considering the experimental errors for their mass measurement, the difference of the fitted $\Lambda$ values for the $\Sigma_c\bar{D}^*$ and $\Sigma_c^*\bar{D}^*$ becomes subtle.

Under the S-wave hidden-charm molecular state assignment to $P_c(4380)$ and $P_c(4450)$, the parities of $P_c(4380)$ and $P_c(4450)$ are negative. However, the LHCb’s measurement suggests that $P_c(4380)$ and $P_c(4450)$ havesystems and $\Lambda=$1.54 GeV for the $\Sigma_c^*\bar{K}^*$ systems from the experience of $P_c(4380)$ and $P_c(4450)$, there only exist two charm-strange molecular pentaquarks $P_{cs}(3340)$ and $P_{cs}(3400)$ corresponding to the $\Sigma_c\bar{K}^*$ $(I=1/2,
J^P=3/2^-)$ molecular pentaquark with $E_{bin}=-3.88$ MeV and the $\Sigma_c^*\bar{K}^*$ $(I=1/2, J^P=5/2^-)$ system with $E_{bin}=-6.94$ MeV, respectively. We denote these two charm-strange molecular pentaquarks as $P_{cs}(3340)$ and $P_{cs}(3400)$, where the numbers 3340 MeV and 3400 MeV are their mass deduced from the relations $m_{\Sigma_c}+m_{\bar{K}^*}+E_{bin}$ and $m_{\Sigma_c^*}+m_{\bar{K}^*}+E_{bin}$, respectively. In other words, we adopt their masses to name these two predicted charm-strange molecular pentaquarks. The possible decay channels of $P_{cs}(3340)(I=1/2, J^P=3/2^-)$ and $P_{cs}(3400)(I=1/2, J^P=5/2^-)$ are shown in Table \[decaypcs\]. As shown in Fig. \[pcs\] (b), $P_{cs}(3340)$ and $P_{cs}(3400)$ can be produced via the $\Lambda_b\rightarrow
\bar{D}^0P_{cs}^0$ decay at LHCb.

In the search of the charm-strange