the court of common pleas pending resolution of an underlying issue by the PUC is not novel in the area of public utility law. In Lansdale Borough v. Philadelphia Electric Company, 403 Pa. 647, 170 A.2d 565 (1961), the appellant borough sought an order of court requiring appellee electric company to terminate service to an area which the borough had recently annexed and to which area the borough had, pursuant to the Borough Code (53 P.S. § 47470), the exclusive right to supply electricity. This Court held that a determination of whether the appellee must discontinue service was dependent on an initial determination by the PUC that the appellee was permitted to terminate service. Thus, although the authority to decree termination of service lay only in the courts,equitable form of relief, unless the statute provides for it or unless there is some irreparable harm that will follow if the statutory procedure is followed.'"
[3]  In its Hewitt-Robins opinion, the Supreme Court of the United States noted:

"Indeed, the doctrine of primary jurisdiction is designed to apply `where a claim is originally cognizable in the courts, and . . . enforcement of the claim requires the resolution of issues . . . placed within the special competence of an administrative body. . . .' United States v. Western Pacific R. Co., 352 U.S. 59, 64, 77 S.Ct. 161, 1 L.Ed.2d 126, 132 (1956); see Davis, Administrative Law Treatise, § 19.01 (1958). The practice of the [Interstate Commerce] Commission in making such determination in the first instance, even


layers are laminated, it is necessary to properly remove stray light, and stabilize a signal from a photodetector.
Japanese Unexamined Patent Publication No. 2010-102813 (corresponding to U.S. Patent Application Publication No. US2010/0080166 A1) discloses an arrangement of an optical pickup device that enables to properly remove stray light, and suppress an offset (a DC component) of a tracking error signal, in the case where a large number of recording layers are formed in an optical disc. With this arrangement, it is possible to form an area where only signal light exists, on a light receiving surface of a photodetector. It is possible to suppress an influence of stray light on a detection signal by disposing sensors of the photodetector in the signal light area. Further, with this arrangement, itend
      end

      #
      # Require a gem or gems. If it's not present, show a very nice error
      # message that explains everything and is much more helpful than the
      # normal LoadError.
      #
      # names - a string gem name or array of gem names
      #
      def require_with_graceful_fail(names)
        Array(names).each do |name|
          begin
            Jekyll.logger.debug "Requiring:", name.to_s


communications, aeronautical monitoring and ship tracking. This is the fifth launch in support of Iridium-NEXT by SpaceX and the first of four Iridium missions planned in 2018 to finish deployment of the operational constellation of 75 satellites, all missions are using Falcon 9 launchers. Iridium-5 will re-use a previously flown Falcon 9, first launched on the Iridium-3 mission.

A SpaceX Falcon 9 rocket will launch the 14th operational Dragon cargo spacecraft to the International Space Station on the company’s first mission under NASA’s Commercial Resupply Services Program in 2018. Dragon SpX-14 is part of an extension to the original CRS-1 contract to bridge a gap to the second CRS contract round. The SpX-14 mission will carry International Docking Adapter 3 or the Robotic Refueling Mission 3 as external payloadsWhirlpool’s new smart oven concept uses augmented reality to show you where to place your croissants and pizza. It’s called the Whirlpool Connected Hub Wall Oven, and the AR aspect makes it a little bit unique within the smart oven category.

The oven has a 27-inch transparent LCD display on its front door, which you can use to pull up recipes. Once you select a recipe, the screen will tell you to gather the necessary ingredients and then display where to place food on the racks. In the demo I got to see, the oven suggested placing salmon on a top rack and asparagus on the bottom so that both items would be well-cooked at the same time.

AR comes into play in a couple of ways here, although it


You are here

Ulf-Eirik’s Legacy

Phil Burthem - Jarl Ulf-Eirik (1961 – 2012) was the founding leader and guiding light of the Jomsviking brotherhood from its inception to his untimely death. He was dedicated to improving the standard of re-enactment and the live representation of the early medieval period. He was also determined to spread the enjoyment of a revival of viking culture to the four corners of the globe, regardless of considerations of ethnicity, creed or gender. Following Ulf-Eirik’s death the Jomsvikings have committed themselves to follow these principles to make the Jomsviking Brotherhood ever stronger and more influential.

Philip Burthem, also known as Ulf-Eirik, died in July 2012 at the age of 50. This is the record of his viking memorial ceremony.
In 1985 Phil was among the 5 foundershe’s right, then men will have to be less like Achilles, imposing their will on the world, and more like Odysseus, the crafty, many-sided sojourner. They’ll have to acknowledge that they are strangers in a strange land.


x2 + a[6]) * x2 + a[4]) * x2 + a[2]) * x2 + a[0] + ((((a[9] * x2 + a[7]) * x2 + a[5]) * x2 + a[3]) * x2 + a[1]) * x);
}

template <class T, class V>
inline V evaluate_polynomial_c_imp(const T* a, const V& x, const mpl::int_<12>*) BOOST_MATH_NOEXCEPT(V)
{
   V x2 = x * x;
   return static_cast<V>((((((a[11] * x2 + a[9]) * x2 + a[7]) * x2 + a[5]) * x2 + a[3]) * x2 + a[1]) * x + ((((a[10] * x2 + a[8]) * x2 + a[6]) * x2 + a[4]) * x2 + a[2]) * x2 + a[0]);
}

template <class T, class V>
inline V evaluate_polynomial_c_imp(const T* a, const V& x, const mpl::int_<13>*) BOOST_MATH_NOEXCEPT(V)
{
   V x2 = x * x;
 the device via charge/discharge of the metal nanoclusters functioning as a capacitor, or based on an MIM (Metal/Insulator/Metal) memory phenomenon proposed by J. G. Simmons and R. R. Verderber. In addition, IBM has manufactured a memory device exhibiting an MIM memory phenomenon, using gold particles dispersed in a polymer. As such, the above memory device is characterized in that the gold particles function as a current flow channel.
As mentioned above, the conventionally used organic material having bistability is disadvantageous because it is deposited only by thermal deposition using an expensive evaporator, instead of a simple process such as spin coating, due to the use of the monomer. The conductive polymer may undergo spin coating, however accurate molecular weight and distribution thereof are difficult to obtain. Thus, the reproducibility


triangle edge against each edge in the other triangle).

Let t0 be the start of the time interval [t0, t0 + ∆t] and assume that the positions and velocities in t0 are known. Assume also that the velocities are constant in the interval.
Vertex-face Collision
Let P (t) be the vertex and A(t), B(t), C(t) the vertices of the triangle. Let also Vp , Va , Vb , Vc be their respective constant velocities during the time interval. Thus,
P(t) = P(t0) + tVp,
A(t) = A(t0) + tVa,
B(t) = B(t0) + tVb,
C(t) = C(t0) + tVc.
If there is collision, then
∃t ∈ [t0, t0 + ∆t] such that
∃u, v ∈ [0, 1], u + v = 1, AP(t) = uAB(t) + vAC(t) (Equation 1)
Equation 1 just shows that in the collision timet, P must be inside the triangle ABC. But it is non-linear since u, v, t are unknown and there are factors that depend on two of them. To solve this, another condition is considered: that the triangle normal is orthogonal to the triangle. Thus
AP(t) · N(t) = 0, where N(t) is the triangle normal. (Equation 2)
It is important to note that this equation is not sufficient to verify the collision
since it is true if A(t), B(t), C(t), P(t) are coplanar. However it calculates t and therefore
eliminates Equation 1 dependency on this variable and turns it linear. N(t) is a t^2
term and AP(t) is a t term, so Equation 2 is cubic. The approach to solve it is described in Section Cubic Equations Solver. Equation 2 can result


of analysis is summarized in [*Figure 1*](#f1){ref-type="fig"}.

![Study population and analysis plan. GNI, gross national income; ICT, information and communication technology; OECD, Organization for Economic Cooperation and Development.](fig-1){#f1}

M-Health Policy Readiness: The Scoring System {#s005}
---------------------------------------------

M-health policy readiness is the primary outcome variable for the two statistical analyses conducted in our study. The variable was scored using the following scheme: for each of the 14 m-health activities such as mobile telehealth and mobile disease surveillance, the respondents from each country could identify their program type as informal, pilot, or established. The score for each m-health activity was assigned as 0, 1, 2, and 3, reflecting responses of "unanswered," "informal," "pilot," and "established," respectively. Then the total m-health readiness score was calculated by summing up the scores given for each of the 14 m-healthby ICT Development Index.](fig-3){#f3}

######

Descriptive Statistics and the Associated Factors for m-Health Policy Readiness Among 112 Countries from Multivariate Ordinal Logistic Regression Model

  VARIABLES                                                                     LATE ADOPTERS       THE MAJORITY       INNOVATORS         COEFFICIENT (SE)       ADJUSTED OR


Stiffer skis are generally relied upon for on-piste skiing where carving is the main goal. Those who need a more forgiving construction when high-tailing it through moguls and other off-piste obstacles covet softer skis. Many skis employ a flex somewhere in the middle of the spectrum for better versatility.

Flex is something that we all talk about, but what does it really mean? Obviously, carving skis designed to ski fast are typically stiffer skis, they tend to take more input and be less forgiving. At the same time, the old adage of a soft ski not being a good ski, that has been proven wrong. Especially in recent years, softer skis can in fact have wonderful performance.

We all flex our skis and bend on the tails and it’s allalso confirmed by PCR (Supplementary Fig. [5a](#MOESM1){ref-type="media"}). The episomal rescue vector carrying *CDPK1* was maintained after more than 50 passages in the *CDPK1*^*H/P*^ chromosomal null cells (Supplementary Fig. [5b, c](#MOESM1){ref-type="media"}) while it was lost from the *CDPK1*^*+/H*^ line suggesting that *CDPK1* is indeed essential (Supplementary Fig. [5b, d](#MOESM1){ref-type="media"}).Fig. 2Kinase activity of the *L. infantum* CDPK1.**a** Phosphorylation of proteins immunoprecipitated with CDPK1-HA as determined by autoradiography after in vitro kinase assay followed by electrophoresis in 12% SDS--PAGE. Assays were performed without γ-P^32^-ATP (lane 1), with 2.5 μCi γ-P^32^-ATP (2) and with γ-P^32^-ATP in presence of excess of non-radioactive ATP (3). In an independent set of experiments, assays were performed with immunoprecipitated CDPK1-HA (4) and CDPK1^K61G^-HA (5) both using 2.5 µCi of γ-P^32^-ATP. Lower panels depict the amount of immunoprecipitated CDPK1 involved in


strokes of a Dounce homogenizer while on ice. Cell debris and insoluble material were separated by 30 min centrifugation at 10,000×*g* at 4 °C. Clear supernatants were incubated with anti-HA magnetic beads at 4 °C for 4 h on a gentle rotator. Beads were then washed thrice with lysis buffer (30 sec each) and thrice with 50 mM ammonium bicarbonate by gentle agitation. Those were suspended in 25 µl 50 mM ammonium bicarbonate and trypsin (1 µg) was added and sample was incubated overnight at 37 °C. Trypsin reaction was stopped by acidification with 3% acetonitrile-1% TFA-0.5% acetic acid. Beads were removed and the peptides were purified on stage tip (C18), vacuum dried and solubilized into 10 µl of 0.1% formic acid before MS injection.

LC MS/MS analysis {#Sec17}
-----------------

Peptide samples were separated by online reversed-phase nanoscale capillary liquid chromatography (nanoLC)See how the Dell EMC Data Domain DD3300 delivers cloud-ready enterprise-level data protection in a compact appliance for small or remote IT environment. Learn more:www.dellemc.com/dataprotection Bookmark Video

Dell EMC Intel Cluster Owens provides the Center with robust increase in the overall capacity for the center. Researchers are able to run larger problems and have significant benefits for their research. Bookmark Video


Waterfront at Midnight

Waterfront at Midnight is a 1948 American drama film directed by William Berke, written by Bernard Girard, and starring William Gargan, Mary Beth Hughes, Richard Travis, Richard Crane, Cheryl Walker and Horace McMahon. It was released on June 25, 1948, by Paramount Pictures.

Premise

A detective mistakenly shoots his own brother, who has become a criminal involved with a dangerous boss.

Cast
William Gargan as Mike Hanrohan
Mary Beth Hughes as Ethel Novack
Richard Travis as 'Socks' Barstow
Richard Crane as Denny Hanrohan
Cheryl Walker as Helen Hanrohan
Horace McMahon as Hank Bremmer
John Hart as Woody
Douglas Fowley as Joe Sargus
Paul Harvey as Commissioner Ryan
Keye Luke as Loy

References

External links

Category:1948 films
Category:American films
Category:English-language films
Category:Paramount Pictures films
Category:American drama films
Category:1940s drama films
Category:Films directed by William A. BerkeI love to see what makes an Island tick. Princess Cays is actually on the Island of Eleuthera. It's an interesting place, and we enjoyed the tour we took, which showed us what the Island looks like and the guides told us about life for those that live there.

We had a tour booked through Princess. It was a great tour, given by a local man named Tracey. The Island reminded me of Bonaire. They have the same Donkeys that roam the Island. On Grand Turk, the local people look after the donkeys, so they are very friendly. I even got to feed 4 of them, much to my great pleasure! I've read reviews of Grand Turk with people saying it was boring, but I did not find this


Sun., Sept. 18, 8PM ET/5PM PT on Fox.

Melanie Moore didn't have anything to say but "thank you" when she won 'So You Think You Can Dance.' Friday on 'Good Day LA' (weekdays, 9AM PT on Fox), she'd had a little more time to digest and collect her thoughts about what's next after winning $250,000 and a Gatorade endorsement.

Moore seems most excited about the fact that producer/director/choreographer Kenny Ortega, who is working on a remake of his film 'Dirty Dancing,' has expressed interest in working with her. "Yes!" she said. "I hope so. And everybody saw that, too. It's a verbal contract, right? Yeah."

It's been an exhilarating summer, but this season of 'So You Think You Can Dance' (Thurs., 8PM ET on Fox) is finally at an end, andbecause we think you're all fantastic now."

!!SPOILER ALERT!!

That's probably why there were smiles of pride on the faces of Clarice and Mitchell, even as they were cut from the competition. It looks like America agreed with our assessment that Mitchell had the weakest night. As for Clarice, while she has struggled to stand out this season anyway, Bollywood did her no favors.

The addition of the All-Stars this week on 'So You Think You Can Dance' (Wed., 8PM ET on FOX) did not disappoint, with almost every dancer upping their game to rise up to their partner. But no one grew so much as a performer than Caitlynn, who was paired with Pasha.

Pasha is one of the most exciting ballroom dancers to ever grace the 'SYTYCD' stage, and the


designed to crack that way at all. Period.”

It’s not clear how widespread the issue is, but so far inspectors have only found a “small” number of cracked pickle forks in the 737 NG line, according to the FAA. According to KOMO, “light cracking” is sometimes found in pickle forks but it is considered “very unusual.”

“A crack like this is similar to when you see a crack in a coffee cup handle,” the retired engineer told KOMO. “You can likely continue using the cup several more times, but there’s always a risk that handle will break off and hot coffee will wind up in your lap.”

Both the FAA and Boeing emphasized that the inspection process worked in this instance and repairs would be carried out where necessary.

“Boeing notified thein which conflicting sensor data caused MCAS to trigger and push a 737 Max’s nose down. The key finding was that faulty sensor readings combined with erroneous MCAS activation “produced a cascading number of warnings that may have overwhelmed the pilots,” according to the New York Times.

Boeing had insisted that pilots were adequately trained to resolve those issues with standard emergency procedures. American Airlines pilot union spokesman Dennis Tajer disagreed, telling the Times , “They completely discounted the human factor component, the startle effect, the tsunami of alerts in a system that we had no knowledge of that was powerful, relentless and terrifying in the end.”

The FAA has denied another finding by the U.S. Office of Special Counsel that its safety inspectors were underqualified and that it misled


Ask HN: How do you maintain good habits with a disruptive career and life style? - DollarGuru
If you travel regularly or have work deadlines etc that disrupts any kind of healthy routine how do you maintain good habits like exercising, meditation, etcetera?
======
rficcaglia
For me, I had to turn this on its head. Define the habits and healthy routine
you want and build the lifestyle around it.

I was on a crash course for 15 years as a tech exec. 90+ hours work per week,
travel, etc. not by compulsion or financial necessity but by personal drive to
be the best at what I was doing. Unfortunately I was literally killing myself.

In 2013 I stepped back, applied an engineering/tech startup process to
researching and analyzing what I really wanted and needed in terms of health
anddon’t often do that. We write for others in the vain hope that at least a few of them will get a little enjoyment out of it before they go back to doing whatever it is they do.

And in that sense, we become more than ourselves.

It is what a lot of people do. They acquire a skill or master an art, so that someone, somewhere might say, “hey, look at that!” and they can blush with pride.

Some take it to extremes. They build skyscrapers. They create empires. They have their image carved into stone and mounted on a marble pedestal – all to become known and in some sense become a bit immortal.

But then there is Oscar. He is about as close to immortal as you can get.

50


reverts back to the heating operation so that heating of the indoor is performed. Additionally, in this refrigeration apparatus, in order to reduce noise that occurs when reverting to the heating operation after the end of the defrost operation, stopping the compressor before entering the heating operation is performed. Furthermore, reducing the acceleration rate of the compressor after reverting to the heating operation is performed.for themselves, their families, or their friends at the regular $15 or $12.50 price (depending on quantity) plus shipping, and/or donate as many telescopes as they'd like for $12.50 each, with no shipping charges. Donated Galileoscopes will go to less advantaged schools and other organisations worldwide, especially in developing countries. This will help bring a modern education to students in poor schools and empower them to pursue science and technology knowledge. Donating Galileoscopes increases the project's global impact and gives people who might otherwise never have the opportunity to look through a telescope the chance to join millions of skywatchers worldwide in a shared experience of astronomical discovery.

The Galileoscope is named after the Italian astronomer Galileo Galilei, who first observed the heavens through a telescope 400 years ago.


Heroku tries to infer which buildpack it should use. Basically, it iterates through officially supported buildpacks in a given order and uses each buildpack's detection script to see if the project appears to match that buildpack.
Once it finds a matching buildpack it stops looking. In simple cases this is often sufficient. But each buildpack is designed to generate a fairly lean image; tools that you might expect to exist on a regular Linux box won't necessarily be present. In particular, the Java/Kotlin buildpack won't give you a python binary.
The good news is that with a bit of configuration you can use multiple buildpacks.

First, set your main buildpack: heroku buildpacks:set heroku/java
Then, add your secondary buildpack: heroku buildpacks:add --index 1 heroku/python
Make sure your buildpacks are shown in the correct orderThe candidate is a junior researcher with considerable experience in studying hepatic stellate cells (HSCs), liver fibrosis and gene regulation. However, to transition into a completely independent translational investigator, the candidate needs a period of additional supervised training. The NIDDK K01 award will enable the candidate to achieve this objective through a combination of academic coursework, didactic training, focused symposiums/conferences, and implementation of the proposed research project. The project will be carried out in the Gene Expression Laboratory at the Salk Institute for Biological Studies which provides a scientifically vibrant and inspiring environment and well-established state-of-the-art research facilities ideally suited to study human disease such as tissue fibrosis. In this regard, HSCs have been recognized as a pivotal regulator of liver fibrosis However, their role in mediating pro-inflammatory


"Don't you know how to walk?" "Where did we find her?" "Who are you?" "Hello!" "How is everyone?" "I'm Chan Hsiao Wan." "I eat big bowls of stewed pork over rice." "My nickname is" ""Slacker"." "Not a pretty name?" "This is my 382nd audition." "I should've been born in a world of high-end fashion." "But God must have made a mistake." "Here's the file for Chan Hsiao Wan." "Load it into your computer." "And by accident I ended up among a bunch of vegetables." "My dad was a famous catering master in the South." "Known as Master Fly Spirit." "8 flies." "My stepmother is known as" "Puffy." "This isn't just some ordinary fish." "It's a friend of "Vicky the Viking"." ""Luffy" is its name." "You know, Luffy fromis." "You made it yourself?" "Yes." "Feel free to try it." "It has a tea flavor." "You're an expert." "We soak it with tea leaves." "Dump that asshole!" "Such a stupid girl." "Who are you talking to?" "Hsia." "Hsia?" "Who's she?" "A character on this show." "Why haven't you taken a bath yet?" "The show's not over." "When are you going back?" "I'm not going back." "Why?" "I'm on the run." "Maybe we can run away together." "How much you owe?" "Around 900 thousand." "That's a lot!" "Hard to make money in the AV business?" "You're not popular anymore." "You silly girl." "Dump that asshole." "Hey, what are you looking at?" "Just checking on their business today." "They have a new "spicy" girl." "But their business isn't any


your hand." "Like this?" "That's right." "Got it." "Nice!" "Really." "Nice!" "It's damn delicious." "Damn delicious." "Yummy." "We're going to win!" "We are!" "How's it going?" "Finished." "Here." "Slacker, try it." "Hurry." "No, thanks." "I don't eat fish." "But we're making fish tomorrow." "You're not going?" "That's right." "Even if you might be on TV?" "On TV?" "Yeah." "Hurry up." "Okay." "I need to put on more make up." "Taiwan's first National Catering Contest has started it's second round." "Today's category is fish." "Let's see what amazing dishes the top 10 chefs will prepare for us." "It's show time!" "Miss Wan looks so beautiful." "Nice!" "Go for it!" "Go Wan." "Okay, our judges have started their evaluating." "Let's wait patiently." "Okay, the time has now come for ourturnip aged for 40 years." "How do I use it?" "We have our hands, and they have their mouths." "No matter how good your cooking is, you can't satisfy everyone." "But if your heart is full of joy, the food will taste good." "Thank you." "No thank you." "Uncle!" "You surf the web, too?" "Live to learn and learn to live." "Demon!" "So cool!" "(The Leftover Stew)" "Miss Wan!" "Ladies and gentlemen, today is the final round of the contest." "Both finalists have already started preparing." "The Banquet Contest starts at 6 tonight." "Stooge B, how's it coming along?" "Finished 20, 2 more to go." "I knew you'd be great." "Keep at it." "Hey hey hey." "And you?" "I don't know what I did to deserve this." "Having


lot of people came." "And enjoyed the same flavors as 50 years ago." "In addition to the 1 million prize money, the champion will cater a State Dinner." "In addition to the 300 thousand prize money, 2nd place gets a contract from the government to design lunch boxes for the rail road." "We have to make lunch boxes for the prize." "First, I'd like to thank our organizer." "I'm Liao Yi Tsai." "People call me Master Tsai." "Everyday, I put my heart into making food whose taste and flavor are wonderful beyond words." "Therefore, winning the championship today is a confirmation of your choice." "Excellent!" "Yes, Master Wan, any words to share about the award?" "Thanks." "Brief but powerful." "Yes." "What a perfect ending to the First Nationaltarget in the cytoplasm (usually tubulin) or can cross into the nucleus and cause cell cycle arrest and apoptosis by interfering with DNA.[@cit0007] Almost all payloads in clinical development are small hydrophobic molecules, that are able to cross biomembranes once cleaved from the ADC.[@cit0008] Therefore, nuclear DNA as well as the cytoskeleton in the cytoplasm are suitable locations for the payload to interfere with critical cellular mechanisms resulting in cell death.

The majority of ADCs have clinical efficacy through on-target on-tumor effects; however some ADCs also cause off-target on-tumor cell killing, referred to as the bystander-effect.[@cit0009] This effect exploits the ability of payloads to cross cell membranes and exert their cytotoxic effect on neighbouring cancer cells that lack target antigen expression. The payload may be cleaved from the antibody


had restricted success in the clinic, internalizing ADCs are still at the forefront of the development of targeted anti-cancer therapeutics.[@cit0003]

ADCs in clinical use {#s0002}
====================

After decades of failure with the first approved ADCs being withdrawn from the market due to fatal cytotoxicity,[@cit0012] ADCs are now one of the fastest growing fields of oncology therapeutics. There are currently four FDA- and EMA- approved ADCs within clinical practice with durable clinical responses reported: gentuzumab ozogamicin (Mylotarg™) targeting CD33 expressed by acute myeloid leukemia (AML) has just been re-approved in the US, after being withdrawn in 2010,[@cit0013] brentuximab vedotin (Adcetris™) which targets CD30 expressed by Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (ALCL),[@cit0015] trastuzumab emtansine (Kadcyla™, also known as T-DM1) targeting HER2 expressed by 20--25% of breast carcinomas and other solidtumor types[@cit0016] and the recently-approved inotuzumab ozogamicin (Besponsa™) targeting the B-cell lineage marker CD22, expressed on acute lymphoblastic leukemia cells.[@cit0017] ([Table 1](#t0001){ref-type="table"}). Since their approval, there has been significant growth in this class of oncology therapeutics, with over 65 agents in early and late stage clinical trials (see [Table 2](#t0002){ref-type="table"} for ADCs in Phase I/II, II and III clinical trials). Table 1.Approved ADCs in clinical use.ADCDeveloperIndicationTarget AntigenAntibody Type/mutationsLinkerCytotoxinYear of approvalGemtuzumab ozogamicin (Mylotarg™)PfizerAcute myeloid leukemiaCD33Humanised IgG4 IgG4 κ antibody hP67.6Acid-labile hydrozone bifunctional linkerCalicheamicinFDA Approved in 2000 in the US, withdrawn in 2010, re-approved in 2017Brentuximab vedotin (Acetris™)Seattle GeneticsRelapsed Hodgkin Lymphoma and systemic anaplastic large cell lymphomaCD30Chimeric IgG, fusion of the variable heavy and light region of the murine anti-CD30 antibody AC10 with the *constant gamma1-heavy* and *kappa-light* region of the human


toxicities. However the ADC has been re-approved this year for the treatment of acute myeloid leukemia.[@cit0012] More IgG4 ADCs are currently being evaluated in clinical trials.[@cit0060]

Fc domain engineering strategies {#s0005-0003}
--------------------------------

Another method to modulate the ability of ADCs to engage the immune system is to engineer their Fc domains. A widely used method to enhance their ability to recruit the immune system and to trigger effector functions is antibody glycoengineering, such as the production of afucosylated IgGs. J6M0-mcMMAF (anti-BCMA IgG1-MMAF) is the first afucosylated-ADC that entered a clinical trial for the treatment of multiple myeloma.[@cit0070]

If the sub-class of choice is IgG1, the Fc portion can be engineered to introduce a single point mutation, or a combination of mutations, to enhance or impair IgG1 binding to FcγRs or complement (C1q),an ADC.[@cit0075]

ADC design based on biodistribution considerations {#s0005-0004}
--------------------------------------------------

Stand-alone small molecule therapeutic agents such as those conjugated to ADCs can be widely distributed in the body. In contrast, antibodies are restricted primarily to plasma and extracellular fluids, and have been shown to target tissues that express the relevant antigen(s). ADCs typically retain the pharmacokinetic properties of their antibody component[@cit0003] as opposed to the attached drug, and thus exhibit relatively low clearance and longer half-lives.[@cit0077]

Despite the optimization of therapeutic antibodies and the availability of antibodies with higher affinity for the tumor than for normal tissues, the amount of antibody that reaches a tumor is only a small percentage of that administered (e.g., approximately 1--2%).[@cit0001] For this reason the use of recombinant antibody fragments for ADC production has been evaluated. Antibody


fragments such as diabodies are much smaller then IgGs (around 50 kDa versus 150 kDa) and thus have superior tissue penetration abilities. However, due to their smaller size and the lack of the Fc portion that usually binds to FcRn, diabodies are cleared much faster than whole IgG isotypes.[@cit0080] A promising anti-CD30 diabody-drug conjugate has already demonstrated high anti-tumor activity,[@cit0081] but the use of diabodies for ADC design needs further study and optimization with a view to striking a balance between optimum tissue penetration and low clearance rates.

The Fc portion of an ADC is responsible for ADC-mediated effector functions and pharmacokinetics. Therefore, these biological properties can be optimized according to therapeutic requirements via engineering and glycoengineering.

Conclusion {#s0006}
==========

Over the past decade, research efforts have focused on linker chemistry and optimizing cytotoxicenveloping algebras of post-Lie algebras, the so called D-algebras prominent in the Lie–Butcher calculus [@EFLM; @LM]. Those algebras are obtained via an adjunction not arising from change of algebraic structure and, as a consequence, are a bit different; a PBW type theorem for them is true on the nose because of the Lie-theoretic nature of the definition.

Acknowledgements.  {#acknowledgements. .unnumbered}
------------------

I am grateful to Vsevolod Gubarev for a discussion of results of [@Gu2], and to Murray Bremner for his comments on the paper [@DT], and particularly for a query as to how results of that paper may be applied to post-Lie algebras.

Recollections
=============

This is a short note, and we do not intend to overload it with excessive recollections. For relevant information on symmetric operads and Koszul duality, we refer the reader


$\alpha$, so we use the name $a_1\triangleleft a_2$ for the operation $[a_1, R(a_2)]\in \operatorname{\textsl{RBLie}_1}$. In line with the usual shuffle operad approach, we denote the opposite operation $a_2\triangleleft a_1$ by $a_1\overline{\triangleleft} a_2$.

Let us show that the shuffle operad $\operatorname{\textsl{RBLie}_1}$ can be presented by the following rewriting system: $$\begin{gathered}
[a_1, R(a_2)]\to a_1\triangleleft a_2,\label{eq:PLelimR}\\
[R(a_1),a_2]\to -a_1\overline{\triangleleft} a_2,\label{eq:PLelimR'}\\
R(a_1)\triangleleft a_2\to R(a_1\triangleleft a_2-a_1\overline{\triangleleft} a_2+[a_1,a_2]),\label{eq:PL-R-a}\\
a_1\overline{\triangleleft} R(a_2)\to R(-a_1\triangleleft a_2+a_1\overline{\triangleleft} a_2-[a_1,a_2]),\label{eq:PL-a-R}\\
a_1\overline{\triangleleft}[a_2,a_3]\to  - [a_1\overline{\triangleleft} a_3 ,a_2]  +  [a_1\overline{\triangleleft} a_2,a_3],\\
[a_1,a_2\overline{\triangleleft}a_3] \to  [a_1,a_3]\triangleleft a_2  -  [a_1 \triangleleft a_2,a_3],\\
[a_1,a_2\triangleleft a_3]\to [a_1,a_2]\triangleleft a_3 - [a_1\triangleleft a_3,a_2],\\
[a_1,[a_2,a_3]] \to -[[a_1,a_3],a_2] + [[a_1,a_2],a_3],\\
a_1\overline{\triangleleft} (a_2\triangleleft a_3)\to (a_1\overline{\triangleleft} a_2)\triangleleft a_3-(a_1\triangleleft a_3)\overline{\triangleleft} a_2 + (a_1\overline{\triangleleft} a_3)\overline{\triangleleft} a_2 - [a_1,a_3]\overline{\triangleleft} a_2,\\
a_1\overline{\triangleleft}(a_2\overline{\triangleleft}a_3)\to (a_1\overline{\triangleleft}a_3)\triangleleft a_2 - (a_1\triangleleft a_2)\overline{\triangleleft}a_3 + (a_1\overline{\triangleleft}a_2)\overline{\triangleleft}a_3 - [a_1,a_2]\overline{\triangleleft}a_3,\\
a_1\triangleleft (a_2\triangleleft a_3)\to a_1\triangleleft(a_2\overline{\triangleleft}a_3)-a_1\triangleleft[a_2,a_3] - (a_1\triangleleft a_3)\triangleleft a_2 + (a_1\triangleleft a_2)\triangleleft a_3.\end{gathered}$$ We first focusalways, the opposites of the corresponding operations. We consider the path-lexicographic ordering of tree monomials induced by the ordering $$[-,-]< (-\bar{\triangleleft}-) < (-\triangleleft-) < (-\circ-) < (-\triangleright-) < (-\bar{\triangleright}-) .$$ A slightly tedious but direct computation shows that the operad above has a quadratic Gröbner basis for this ordering of monomials; moreover, the space of arity four elements of this operad has dimension $1080$. However, the dimension of $\operatorname{\textsl{TriDend}}(4)$ is equal to $45\cdot 4!=1080$ as well, so both surjections constructed along the way are isomorphisms, and our rewriting system for the shuffle operad $\operatorname{\textsl{PostPoisson}}$ is convergent. Finally, we observe that the leading terms of our Gröbner basis do not involve tree monomials obtained by the right module action of $\operatorname{\textsl{PostLie}}$, so [@Dot09 Th. 4(2)] applies, proving freeness of $\operatorname{\textsl{PostPoisson}}$


on Lie groups and post-Lie algebra structures. Linear Alg. Appl. 437:5, 1250–1263 (2012). Burde, D., Dekimpe, K.: Post-Lie algebra structures and generalized derivations of semisimple Lie algebras. Moscow Math. J. 13:1, 1–18 (2013). Dotsenko, V.: Algebraic structures of F-manifolds via pre-Lie algebras. Ann. Mat. Pura Appl. (1923 -), in press. Dotsenko, V.: Freeness theorems for operads via Gröbner bases. Sémin. Congr. 26, 61–76 (2013). Dotsenko, V., Tamaroff, P.: Endofunctors and Poincaré–Birkhoff–Witt theorems. ArXiv preprint `1804.06485`. Ebrahimi-Fard, K.: Loday-type algebras and the Rota-Baxter relation. Lett. Math. Phys. 61, 139–147 (2002). Ebrahimi-Fard, K., Lundervold, A., Munthe-Kaas, H. Z.: On the Lie enveloping algebra of a post-Lie algebra. J. Lie Theory 25:4, 1139–1165 (2015). Ebrahimi-Fard, K., Manchon, D.: The tridendriform structure of a discrete Magnus expansion. Discrete and Continuous Dynamical Systems, printf("draw content\n");
	    result = noErr;
	    break;
	case kEventWindowClickContentRgn:
	    printf("click_content region\n");
	    break;
	case kEventWindowHandleContentClick:
	    err = GetEventParameter(theEvent, kEventParamMouseLocation,
				    typeQDPoint, NULL, sizeof(where), NULL, &where);
	    GetWindowBounds(window, kWindowContentRgn, &bounds);
	    printf("content click %d, %d; %d, %d\n", where.h, where.v,
		   where.h - bounds.left, where.v - bounds.top);
	    break;
	}
    }
    return result;
}

pascal OSStatus app_handler(EventHandlerCallRef nextHandler, EventRef theEvent, void *data)
{
    plate_edit *pe = (plate_edit *)data;
    HICommand hiCommand;
    OSStatus result = eventNotHandledErr;
    GetEventParameter(theEvent, kEventParamDirectObject, typeHICommand,NULL,


Nissan Repairs

SC Auto Air Can Meet All Your Nissan Repair and Maintenance Needs

When you visit SC Auto Air, located in Santa Clarita, CA, 91351, you will meet our team
of highly-trained, knowledgeable Nissan technicians who are ready to handle any
problems you experience with your Nissan vehicle. Our staff understands everything
about the Nissan brand.

Nissan is a Japanese automaker that offers vehicles ranging from compact cars to
large SUVs and crossovers, and is brand sibling to Infiniti, a luxury-level brand.
Nissan combines wild styling, entry-level luxury and cutting-edge technology at an
affordable price.

There will come a time when your Nissan vehicle, new or used, will need to have
maintenance or repairs completed. There will always be general maintenance, but you
could see problems with the engine, interior quality over the life of the vehicle or
electronics, dependingto splurge once in a while. if you are selecting your splurge item for Fall, i would suggest the gorgeous Palette Couture. watch your girlfriends swoon as you touch up your blush.

Tuesday, July 10, 2012

Laura Mercier's Cinema Noir is a formidable Fall/Winter 2012 collection. aiming for a modern look with a dramatic twist, you will find smoky eyes, highlighted cheekbones and chic nail lacquers in shades of cocoa. say goodbye to the brights of Spring/Summer and hello to the deep tones of Fall/Winter.

Laura Mercier collections are always a win because they provide universally flattering shades. my sister teases me because i refer to them as a mature makeup. what i mean by that is Laura Mercier follows the trends but isn't overtly trendy. you won't find shocking lime


spring morning at Laurelhurst was Facteau’s first run of the season. Discomfort during past runs in her minimalist shoes forced her to stop running for three months. But the long-time runner was anxious to hit the trails again. The hype about barefoot running attracted her. Though she researched online before purchasing barefoot shoes, Facteau has since realized the reviews were one-sided. Now that she’s learned the hard way, she wishes there had been more information about the potential harm from barefoot running. “I didn’t read anything from any doctors, it was other runners giving the thumbs up,” says Facteau. And as she slowly transitioned into running with minimalist shoes, she dismissed odd aches and pains in her hips, legs, and calves. “I have a strong opinion against themvenue, speakers service, it was just great! We are looking forward to Baltimore and seeing our peers once again."Cindy Staffieri
Zenan

"SGCD exposed me to new techniques and products as well as the best explanation and educational experience about Prop 65 I have ever listened to, thank you very much."Dustin Kurath
first time attendee, Deco '15

Deco News Advertisers

Our Corporate Members

The information contained in this website is for general information purposes only.

The information is provided by the Society of Glass and Ceramic Decorated Products (SGCDpro) and while we make every effort to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related


content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.]

DATA PROTECTION Any personal information submitted via this website, whether by email or other means, will be used solely by SGCDpro and will not be disclosed to any third parties.Today, many, maybe most, celebrities endorse products. And that means brands face a challenge when their endorser suddenly shows up in the news for the wrong reasons: a drug scandal, domestic violence charge, hate speech, even shoplifting. 409 more words

AUBURN – Mississippi State senior Roquez Johnson can’t keep count of how many family members and friends will make the trip up I-85 North to Auburn Arena to watch him play Wednesday night. 590 more words

Despite fears to the contrary, the inaugural season of the College Football Playoff was a resounding success for the Football Bowl Subdivision. It was particularly kind to Ohio State, which captured the national championship with a 42-20 win against Oregon. 2,478 more words

AUBURN – As had been the case most of the season, costly


flags.
 * Experimental feature: CMake build script (requires CMake 2.6.4+).
 * Experimental feature: the Pump script for meta programming.
 * double values streamed to an assertion are printed with enough precision
   to differentiate any two different values.
 * Google Test now works on Solaris and AIX.
 * Build and test script improvements.
 * Bug fixes and implementation clean-ups.

 Potentially breaking changes:

 * Stopped supporting VC++ 7.1 with exceptions disabled.
 * Dropped support for 'make install'.

Changes for 1.4.0:

 * New feature: the event listener API
 * New feature: test shuffling
 * New feature: the XML report format is closer to junitreport and can
   be parsed by Hudson now.
 * New feature: when a test runs under Visual Studio, its failures are
   integrated inIn September, pioneering computer-science researcher Gordon Bell and his Microsoft Research colleague Jim Gemmell published Total Recall: How the E-Memory Revolution Will Change Everything, a book that summarizes nearly a decade of an effort to record digitally everything in Bell’s life: What he did, what he saw, what he read, some of what he ate, what he felt—his entire life experience. The book is written in Bell’s voice, but the publication, like the MyLifeBits project that generated it, is a true collaboration. Bell and Gemmell recently found time to discuss the genesis of the research—and its implications for us all.

Q: How is the book being received?

Gemmell: We’re getting a really good reception. We’ve heard from entrepreneurs who are inspired by it and from typical people who are excited


lives, and, in a way, we sometimes neglect the more personal uses. Most families recognize them: better tools for logging your life, easier ways to show a timeline.

Gemmell: There’s software that exists in research to do automatic summarization of content and automatically come up with stories. More of that software coming out is critical to the momentum of Total Recall. Software will come out to automatically classify stuff. And then there is the ease of use of simple things like backup and replication. It’s too complicated to explain to my parents how to manage their information and keep it safe. It’s got to be a no-brainer.

Gordon, being our chief guinea pig in this, has gone through a lot of pain and hassle changing batteries, charging devices, and installingfor building patios, amongst the most popular are: cobbles, granite, sandstone, slate, limestone, concrete, slabs, composite blocks, bricks, asphalt, gravel, setts and blocks.

Patio builders can help with the installation of patios and: patios around swimming pools in the UK, patio sealing in the UK, patios around shrubs and trees in the UK, jet washing of patios in the UK, patio cleaning in the UK, patio removal and disposal in the UK, block paving patios in the UK, natural stone patios in the UK, garden patios and terraces in the UK, patio grouting in the UK, permeable patios in the UK, the repair of patios in the UK, decorative patio layouts in the UK, garden patios and driveways in the UK, budget patios and terraces in the UK, concrete


sucking, compressing and discharging, and a oil feeder 0 fixedly combined at the outside of the compression unit C, to provide oil to each contact sliding portion (sliding portion) of elements.
As shown in FIG. 2, the oil feeder O includes a oil cylinder 21 attached onto the bottom surface of the compression unit C, a oil piston 22 inserted in the oil cylinder 21 and dividing the inner space of the oil cylinder into a suction space and a discharge space; a first and a second oil springs 23a and 23b positioned at both ends of the oil piston 22 to elastically support the oil piston 22; a oil suction valve 24 contacted to an oil outlet of the oil piston 22 and supported by the second oilan oil inflow path, 1b denotes a first oil pocket, 1d denotes a oil circulation path, 1e denotes an oil discharge hole, 3 denotes a cylinder, 3a denotes an oil opening, 4 denotes an inside/outside lamination assembly, 5 denotes a magnet assembly, 6 denotes a piston, 7 denotes a suction valve, 9 denotes a suction pipe, 11 denotes a discharge cover, 12 denotes a discharge valve, 13 denotes a valve spring, 26 denotes a suction cover, 27 denotes a discharge cover, S1 denotes a suction space, and S2 denotes a discharge space.
Operation of the oil supply apparatus of the linear compressor constructed as described above in accordance with the conventional art will now be explained.
When the compression unit C is oscillated along with a magnetic assembly 5 in


look at authentication mechanisms such as asymmetric cryptography.
This is a hard part. Even if you hard code the download url in the app, people can still make a fake webserver to send the files/data by changing DNS or doing all sorts of things. At the end of the day, you will only be making things harder to break into, not 100% secure.

Q:

Creating a PHP array with values from a function

I want to create an array with x elements, where each element is created by calling a function. I'm looking for an idiomatic way to do this that minimizes state, especially mutating state, and also minimizes imperativeness.
I have working code that does this task, more specifically it creates an array with 10 elements using a function that returns a random character.
array_map(
    function() use ( $characters, $characterCount ) {
        return $characters[mt_rand( 0, $characterCount - 1 )];
    },
    array_fill( 0, 10, null )
)

When starting with this I was looking for something like the following, but did not find it:
array_create(
    function() {},


in posterior region of maxilla were considered for review These radiographs were taken previously for different diagnostic and treatment purposes. A total of 258 defect sites were observed in 100 patients with 144 maxillary sinus exposures. Both male and female patients aged between 35 and 70, who were diagnosed with chronic periodontitis, were considered. Patient\'s previous records and periodontal charting were observed to correlate periodontal status and other histories for maxillary sinusitis.

Exclusion criteria {#sec2-1}
------------------

Categorizing odontogenic and nonodontogenic sinusitis was done according to the Abrahams guidelines.\[[@ref17]\] Patients with preexisting maxillary sinusitis because of nonodontogenic origin, previous history of trauma, teeth with dental caries or periapical pathologies, pregnancy, nursing, history of using antibiotics in the past 2 months, patients who underwent any periodontal treatment 6 months before CBCT investigation, andedentulous areas or implants were excluded from the study.

Evaluation of images {#sec2-2}
--------------------

CBCTs were taken (exposure: 90 KV, 2.5 mA, 15 s and dose: 1179 mGy.cm^2^), and measurements were recorded with the software (CS 3D imaging, v3.3, NY, USA) and calibrated by two dental graduates under the supervision of two oral and maxillofacial radiologists with a minimum of 2 years of experience in evaluating CBCT and the average was noted. The bias between inter-examiner calibrations was eliminated by calibrating 30% of images again.

Measuring Schneiderian membrane thickness {#sec2-3}
-----------------------------------------

MMT was measured at the thickest area of the membrane perpendicularly from the underlying bone. The measuring line of MMT should be a continuation of the measuring line of RBT. Mucosal thickness grouped into two: (a) ≤2 mm as normal \[[Figure 1](#F1){ref-type="fig"}\] and


prejudicial and did not contribute to the defendant's conviction.
In this case the killing resulted from an exchange of bullets when Franklin allegedly sought to rob the victim's liquor store. The primary thrust of the state's case was felony murder. In closing argument felony murder was the dominant theme, and, indeed, the facts demonstrate felony murder more clearly than premeditation. It is at least as likely as not that the jury based its verdict on felony murder. The failure to instruct on the underlying felony cannot be considered harmless error in this case. Compare Jones with Knight v. State, 394 So.2d 997 (Fla. 1981).
While it is not necessary to instruct on the elements of an underlying felony with the particularity required if that felony were the primary case charged,Parador de Trujillo

Santa Beatriz de Silva, 1 - Trujillo - Spain

In the monumental city of Trujillo, birthplace of discoverers, this
beautiful hotel stands on the former convent of Santa Clara preserving
the peace and quiet atmosphere that gives it its structure convent.
Inside, there are two beautiful cloisters, one Renaissance with arches
and columns, the second set provides a note of luminosity which
embellishes the surroundings. Ideal for relaxation, leisure and work,
the hotel has rooms and details of monastic character, spacious lounges,
quiet and pleasant rooms in which noble raw wood and a coffee bar next
to the cloister of the Parador light.

[X] By using our own and third-party cookies, we are able to offer you the browsing experience you want, improve our service and provide you with the advertisements that best suit your preferences.


How Civilizations Fall: A Theory of Catabolic Collapse - aarontait
http://www.xs4all.nl/~wtv/powerdown/greer.htm

======
RyanMcGreal
One of Tainter's more interesting arguments is that collapse, when it occurs,
is a sensible, reasonable response to negative returns on societal complexity.
He notes, somewhat famously, that the average nutrition and health of Romans
actually improved after the collapse of the Roman empire, presumably because
the wealth they generated was no longer being siphoned off to maintain the
empire's overhead.

~~~
run4yourlives
Well, they call it the dark ages for a reason...

Statistics might show improvement because wealth is redistributed, but the
total wealth is also a lot less, which isn't always a good thing.

~~~
pradocchia
It's an example where greater welfare may be derived from less overall wealth,
if a) the marginal benefit of more wealth per member diminishes with each
additional unit, generally, and b) the distribution between members improves,
such        p.dump_default_value,
                                                p.allow_cpu_mem_fwd);
        }
    };
    }
#endif

    template<>
    struct OprLoadDumpImpl<opr::Host2DeviceCopy, 0> {
        using Opr = opr::Host2DeviceCopy;

        static void dump(OprDumpContext &ctx,
                const cg::OperatorNodeBase &opr_) {


       return out_var.node()->owner_opr();
        }
    };

    template<>
    struct OprLoadDumpImpl<opr::ImmutableTensor, 0> {
        using Opr = opr::ImmutableTensor;

        static void dump(OprDumpContext &ctx,
                const cg::OperatorNodeBase &opr_) {
            using Meth = OprDumpContext::TensorWriteMethod;
            auto &&opr = opr_.cast_final_safe<Opr>();
            ctx.dump_tensor({}, HostTensorND{}.copy_from(opr.value()).sync(),
                   CompNode::default_cpu().mem_node()) {
                    mgb_assert(i->storage().ptr(),
                               "storage should not be nullptr if mem_node is "
                               "default_cpu");
                    HostTensorND src{i->storage().comp_node(),


Convention Center.

Mimi Valdés
Editor in Chief of Latina Magazine
Award-winning editor, entrepreneur and speaker. Prior to Latina magazine she was editor of Vibe Magazine and contributing editor at Blaze. She holds NYU degree in journalism. Is best known for her interviews with Jennifer Lopez, Beyonce, Justin Timberlake, Alicia Keys and many more.

A contemporary Latino woman in a traditional role at a non-traditional magazine. She has appeared on ABC’s 20/20, MTV, VH1, E!, BET, CNN, PBS, Fox News and a variety of print publications. She is often called upon as an expert on the Latino role in Pop Culture, Music and style.

From now until the end of May, we will be profiling our Commencement speakers. Commencement is on June 12th, 2010 at Jacob Javits Convention Center.

Gerald GrantJournalist, Historian…Professor at Syracuse University.York, our students are committed to using what they learn both inside and outside of the classroom to transform the world around them. That dedication to helping others has earned us a place on the President’s Higher Education Community Service Honor Roll, the highest federal recognition a college can receive for its commitment to service-learning and civic engagement.

MCNY students and faculty deserve all the credit. This honor goes to each person on this campus that identified a challenge, organized a group of committed individuals and worked to be part of the solution. Teaching kids, managing afterschool programs, helping patients on the road to recovery — our students did all this and more. We believe that service is how we will meet the challenges of our time, and we


  tolled, with the consequence that our court lacks jurisdiction to consider Plaintiffs’ appeal from the

11   judgment.

12          Although Plaintiffs did not file the motion for reconsideration within 28 days as the rule’s

13   literal terms require, they served the motion well within the 28-day period allowed for tolling,

14   raising the question whether the specific requirement to file should be strictly interpreted. The

15   drafting history of FRAP Rule 4(a)(4)(A)(vi) suggests that the requirement to file, rather than

16   serve, a motion for reconsideration within 28 days in order to toll time to appeal was a conscious

17   choice.2 See also Fruit of the Loom, 192 F.3d at 75-77 (distinguishing betweenrather than
     merely served, within the relevant window in order to toll time to appeal:
             If any party files a timely motion of a type specified immediately below, the time for appeal
             for all parties runs from the entry of the order disposing of the last such motion
             outstanding. This provision applies to a timely motion under the Federal Rules of Civil
             Procedure . . . for relief under Rule 60 if the motion is filed


prescribed time limits to give the appellate court jurisdiction over the appeal. In a case in

 8   which the appellant had filed his Fed. R. Civ. P. 60(b) motion shortly after the 28-day tolling

 9   deadline of Rule 4(a)(4)(vi) had expired, our Court stated in dismissing the appeal that “[f]iling

10   deadlines are mandatory and jurisdictional.” Johnson v. Univ. of Rochester Med. Ctr., 642 F.3d

11   121, 124 (2d Cir. 2011) (per curiam). The decision, however, contained no suggestion that plaintiff

12   sought, and we rejected as impermissible, an equitable waiver or exception with respect to the

13   28-day tolling deadline. The decision also included no reference to Bowles or its distinction

14   between statutorily-mandated “jurisdictional” rules and “court-promulgated”a timely

2    appeal from the judgment.6 We must therefore dismiss Plaintiffs’ appeal.7

3                  II. Individual Calendar Rules Requiring Delay in the Filing of Motions

 4          The possibility that a party might forfeit a meritorious appeal because the district judge

 5   announced a personal rule prohibiting the filing of motions is deeply troubling. As discussed

 6   above, it is not so troubling in the present case, first, because counsel had every opportunity to

 7   request relief from the district judge’s prohibition and failed to do so, and, second, because this

 8   appeal appears


(b) -0.1  (c) 380/9
c
What is the smallest value in 4, 3, 44.1, -1/73?
-1/73
What is the fourth biggest value in -2/5, 1/2, -29, 3, 2/13, 1/6?
2/13
Which is the third biggest value?  (a) -0.09  (b) 0.5  (c) -932
c
What is the biggest value in -1/4, 0, 1.5, -1/3, 2, -88?
2
Which is the second biggest value?  (a) 106  (b) -17/2  (c) 0.2
c
Which is the fourth smallest value?  (a) 5  (b) -4  (c) -0.38  (d) -1/37
a
What is the biggest value in -182, -5, -2, -3/14, 0?
0
What is the biggest value in -5.1, 2/209, 0.6, 2?
2
Which is the smallest value?  (a) -82  (b) 0.19  (c) 0.4  (d) 18
a
What is the third biggest value in 2/5, 5, -1/36, -9, 5/12?
2/5
WhichSuccess Kid

in the last ten years since highschool, i have lost a child, a wife, gone through severe bouts of suicidal depression.

got my head on my shoulders now, starting as a freshman in college this week.


0 = -3*n + 5*k - m, -4*n = -5*k - 1 - 1 for n.
3
Let t(n) be the first derivative of -n**2 + 0*n**2 - 1 - 2*n - 2*n + 2. Let c be t(-7). Solve -2*i - r = 0, r = -i - 2*r + c for i.
-2
Let l = 17 - 10. Let m(f) = 4*f**2 + 4*f - l + 0 - 15*f - 3*f**2. Let x be m(12). Solve 2*t + t = -x*a + 2, 3*t - 6 = -3*a for t.
4
Let l(g) = -5*g**2 - 43*g + 2 + 20*g + 21*g. Let r be l(1). Let z be 14/35 - 8/r. Solve -2*f - 10 = z*w, 3*f + 2 = f for w.
-4
Suppose -13 = -5*n +A reversible fluorescent Hg2+ chemosensor based on a receptor composed of a thiol atom and an alkene moiety for living cell fluorescence imaging.
A novel reversible fluorescence turn-on chemosensor 1 for Hg(2+) was constructed based on a new receptor composed of an S atom and an alkene moiety. The sensor showed a large fluorescence enhancement response (1000-fold enhancement), high selectivity, and high sensitivity with a detection limit of 27.5 nM. Significantly, the reversible sensor functioned well in the near pure aqueous medium and could be employed for Hg(2+) imaging in living cells.


covering and dramatic curved descent, is justly famous."

Église de la Madeleine

In 1757, he presented a project for the new Église de la Madeleine in Paris, for which he drew inspiration from Jacques-Germain Soufflot's Église Sainte-Geneviève. Though the foundation stone was laid by Louis XV in 1763, funds lagged, and after Contant d'Ivry's death, the plans were modified, then the partially built structure was razed and begun anew.

Principal commissions
 Château de Bizy, Vernon (Eure), for the maréchal de Belle-Isle (ca 1740, partly destroyed).
 Hôtel d'Évreux, 19 Place Vendôme, Paris : grand staircase and boiseries (1747).
 Château d'Arnouville at Arnouville-lès-Gonesse, for Jean-Baptiste de Machault d'Arnouville. He collaborated there with Jean-Michel Chevotet, (1751–1757).
 Palais-Royal, Paris: In 1752 he provided décors for two main rooms, the salle de la section desWe've all heard calcium builds strong bones and is key to preventing osteoporosis. But did you know taking in the right amount of calcium also has a huge effect on our oral health?

Calcium Benefits Our Oral Health

Does calcium really make a difference in our oral health? The answer is yes! Even before we’re born, we begin storing a supply of calcium and other nutrients to grow strong, healthy teeth and bones. As we grow older, calcium continues to repair and strengthen our teeth, making them more resistant to decay and fortifying them against disease.

Although many foods contain calcium, the best and most easily absorbed source comes straight from milk and dairy products! Milk is not only a rich source of calcium, but of phosphorous, magnesium, and Vitamin D,


Q:

Why is part of previous SwiftUI view showing on newly created view

My first initial view for my app is a splash screen:

This screen has code to check if an authToken is available, if it's not then it will toggle the showLogin bool, which in turn causes my view to go to the LoginView(). Else if there is a authToken available, then it calls a function which fetches information about the user, stores it in an Observable Object and then sets showMain bool to true, which in turn changes my view to my main screen.
It works, but whenever it changes view, it puts the previous view at the bottom of the new view. I know I should use a navigation link for this but I can't get it toto defend an ADT leg title three times, was already two-under at the back nine where he started but stumbled with a triple-bogey on the par-4 No. 1 after an errant approach shot from just around 100 yards. He scored a 73.

“I just made a bad shot and No. 10 but I think I’m still okay. There are still three rounds left,” said Salvador, who nipped Angelo Que by one to complete his back-to-back title romp in this event at the Cebu Country Club last year.

Jay Bayron had a 74, Scotland’s James Byrne came up with a 75 and Frankie Minoza scored a 77 in the Asian Development Tour event sponsored by Aboitiz Equity Ventures, Inc., backed by International Container Terminal Services, Inc.


Brachioradialis transfer for wrist extension in tetraplegic patients who have fifth-cervical-level neurological function.
The brachioradialis tendon was transferred to the extensor carpi radialis longus and brevis tendons to restore active extension of the wrist in nine patients who had traumatic tetraplegia. The classification of neurological function was the fifth cervical level for all patients. The average time from the injury to the operation was six years (range, one to twenty years), and the average duration of follow-up was ten years (range, two to fifteen years). The evaluation of the patient included a determination of the preoperative and postoperative ranges of motion of the wrist, manual muscle-testing of the strength of the brachioradialis and the wrist extensors, a functional assessment of the ability to perform activities of daily living (eating,interview as well as a follow-up health examination in a mobile examination center for each participant. All data presented in this report were collected during the in-person household interview, with the exception of body mass index. Persons who were less than 19 years of age (*n* = 7939), pregnant or lactating (*n* = 184), or had unknown or missing data on the use of dietary supplements (*n* = 4) were excluded, yielding a final analytic sample size of 11,024 U.S. adults. Written informed consent was obtained for all participants or proxies and NHANES survey protocol was approved by the Research Ethics Review Board at the Centers for Disease Control and Prevention, National Center for Health Statistics.

All questionnaire data used for this analysis, including the demographic and lifestyle data


daily drink number was calculated as the number of days a participant reported drinking in the past 12 months multiplied by the usual number of drinks that were consumed divided by the total number of days, and was categorized as 0, 1, 2, or ≥3 drinks/day \[[@B12-nutrients-10-01114]\].

DS use in the previous 30 days prior to the household interview was collected via the Dietary Supplement Questionnaire. Trained NHANES interviewers asked the participant about their use of vitamins, minerals, herbals, and other DS. Participants were asked to show interviewers the containers for all products taken in the past 30 days. For each DS reported, interviewers recorded label information including the product name, manufacturer, form (e.g., tablet), and strengths per serving. Participants were also asked about the consumption frequency, dose, andfor inflation and family size \[[@B19-nutrients-10-01114]\]. The poverty guidelines are updated annually and differ by geographical location (with different cutoffs for the 48 contiguous states, the District of Columbia, Puerto Rico, Alaska, and Hawaii). A PIR ≤ 130% is the cutoff to determine financial eligibility for SNAP, the largest federally funded nutrition assistance program that provides vouchers for food purchases with the objective of reducing hunger and improving the health of low-income individuals and families \[[@B20-nutrients-10-01114],[@B21-nutrients-10-01114]\]. Three PIR categories were constructed for this analysis: ≤130%, 131--350%, and ≥350%. The Food Security Questionnaire was used to collect information on both SNAP participation and adult food security. SNAP participation was assessed based on information collected on whether the respondent was currently a beneficiary. Individuals classified as SNAP income-eligible nonparticipants consisted


BMI, since that data was collected in the mobile examination center. A Taylor Series Linearization approach was used to approximate standard errors (SEs) for all estimates, and statistical comparisons of DS use were evaluated using a univariate *t* statistic. A Bonferroni-corrected *p*-value of 0.0167 was considered statistically significant.

3. Results {#sec3-nutrients-10-01114}
==========

About half of all U.S. adults (52% ± 1.0 SE) took at least one DS in a 30-day period. DS use was higher among women (59%) than men (45%), and use increased linearly with age ([Table 1](#nutrients-10-01114-t001){ref-type="table"}). Specifically, older (71+ years) women had the highest prevalence of DS use (79%), while younger (19--30 years) men had the lowest (32%). Non-Hispanic whites (58%) and non-Hispanic Asians (53%) had a higher use of DS than non-Hispanic blacks (40%) or Hispanics (35%).majority of U.S. adult DS users (66%) took one or two supplements daily ([Table 4](#nutrients-10-01114-t004){ref-type="table"}). During a 30-day period, 61% of DS users took their supplements every day, 12% took them on 20--29 days, 11% took them on 10--19 days, and 15% took DS on fewer than 10 days (data not shown). Among DS users, use of products containing one or more selected vitamins ranged from 45 to 75% ([Table S1](#app1-nutrients-10-01114){ref-type="app"}). These vitamins included vitamins B-6, B-12, C, D, or K. Vitamin K use was the lowest overall (45%), while vitamin D use was the highest (75%). Likewise, between 33 and 71% of DS users took a supplement containing calcium, iron, zinc, magnesium, selenium, or folate during a 30-day period. Supplements containing iron were the least commonly consumed


  50.5 (1.8)   65.1 (1.6) \*   36.7 (1.2) ^a^     32.4 (1.3)   41.0 (1.7) \*
  Good                          4030     49.4 (1.3) ^b^     42.8 (1.5)   56.4 (1.9) \*   29.3 (1.0) ^b^     27.2 (1.2)   31.5 (1.6) \*
  Fair or poor                  2330     49.0 (1.5) ^b^     43.1 (2.3)   54.1 (1.7) \*               45.4 (1.1)   30.2 (1.4) ^a^   41.9 (1.4) ^b^   58.3 (1.6) ^c^   29.1 (2.2) ^a^   48.3 (1.3) ^b^   23.7 (1.5) ^a^     34.1 (2.0) ^b^     52.8 (1.2) ^c^
  Women                58.6 (1.2)   45.7 (2.0) ^a^   58.3 (1.6) ^b^   69.1 (1.7) ^c^   43.2 (1.9) ^a^   61.6 (1.2) ^b^   38.9 (1.8) ^a^     54.1 (2.5) ^b^     65.2 (1.2) ^c^
  **Age**


opined: "Pam Willis embodied the grounded, family-based drama that kept people coming back time and time again. The matriarch of a family of six – with Doug, Adam, Gaby, Brad and Cody – Pam was a tough cookie and was very family orientated. She would stand her corner and help anyone out if they needed her, but it was the day-to-day troubles that the Willis's faced that resonated with viewers."
Michael Cregan of Inside Soap expressed his love for Pam, saying "It's been a tragic time for the Willis family, but the one silver lining is that it's brought Neighbours legend Pam back to our screens again as she says her farewells to grandson Josh."

References

Bibliography

External links
 Pam Willis at BBC Online
 Pam Willis at Neighbours.com

Category:Neighbours characters
Category:Fictional nurses
Category:Television characters introducedother halophenols), Uranium, iron, manganese, oxygen, nitrite, nitrate, nitrous oxide, and fumarate, to name a few. As far as metabolism goes, these bacteria are about as robust as they come. I personally have studied the genomes available for this genera of bacteria for a postdoc proposal. I can tell you, these guys are remarkable on many fronts.

First, Anaeromyxobacter have over half as many c-type cytochromes as the model Shewanella, 69 to 40. Cytochromes are the workhorses of metabolism that guide electrons towards the final electron acceptor like oxygen, iron, or uranium. Cytochromes accomplish this by shuttling electrons on heme groups. It is not uncommon for cytochromes to have multiple heme groups. Remarkably, Anaeromyxobacter has one cytochrome that has an astounding 40 heme groups. Shewanella cytochromes have up to


death-inducing complex II following TNFR1 ligation can initiate caspase-8-dependent apoptosis or, when caspases are inhibited, RIPK3- and MLKL-dependent necroptosis[@b40]. Although normal differentiation of thymic Treg cells was observed in *Mlkl*^−/−^ and *Mlkl*^−/−^*Casp8*^−/−^ mice, the reduction of thymic Treg cells caused by SHARPIN deficiency was not corrected in *Sharpin*^cpdm^*Mlkl*^−/−^*Casp8*^−/−^ mice ([Fig. 5b,c](#f5){ref-type="fig"}). Likewise, loss of *Ripk3* and *Casp8* haploinsufficiency failed to rescue the thymic Treg cell defects in *Sharpin*^cpdm^ mice ([Fig. 5b,c](#f5){ref-type="fig"}).

To test whether the block in conventional thymocyte differentiation observed in *Hoip*^ΔCd4^ mice was caused by complex II-mediated apoptotic cell death, we generated *Hoip*^ΔCd4^*Casp8*^ΔCd4^*Mlkl*^−/−^ mice. Genetic ablation of caspase-8-mediated apoptosis and MLKL-mediated necroptosis failed to restore normal SP thymocyte differentiation or peripheral T-cell numbers in *Hoip*^ΔCd4^ mice ([Fig. 5d](#f5){ref-type="fig"}). Collectively, these data demonstrate that LUBAC is not solelydownregulated (50) genes in CD69^+^ MHC I^low^ and CD69^+^ MHC I^high^ thymocytes from *Hoil*^ΔCd4^ compared with WT mice ([Fig. 6b](#f6){ref-type="fig"}). Reduced expression of many core NF-κB target genes was a common feature of thymocytes from *Hoil*^ΔCd4^ and *Sharpin*^cpdm^ mice. These included genes involved in negative feedback (for example, *Nfkbia* (or IκBα), *Nfkbie* (or IκBɛ), *Birc3* (or cIAP2) and *Tnfaip3* (or A20)) and T-cell differentiation (particularly of FOXP3^+^ Treg cells; for example, *Gadd45b*, *Il2ra*, *Tnfrsf18*, *Tnfrsf4* (or OX40) and *Relb*; [Fig. 6b](#f6){ref-type="fig"}). To determine whether there was a defect in the induction of NF-κB target genes in the LUBAC-deficient strains during the differentiation from CD69^+^ MHC I^low^ into CD69^+^ MHC I^high^ thymocytes, we first identified 154 NF-κB target genes that were significantly up- or downregulated during this transition in


decrease in the numbers and proportions of CD4^+^ Treg cells in the spleen and lymph nodes ([Fig. 7i](#f7){ref-type="fig"} and [Supplementary Fig. 5d,e](#S1){ref-type="supplementary-material"}). To determine whether there was a cell intrinsic requirement for HOIP in peripheral Treg cells, we took advantage of the fact that the *Foxp3*^*YFP*−*Cre*^ knock-in allele is X-linked[@b45] to create chimeras in heterozygous *Foxp3*^*Cre/+*^ females through X-inactivation. Although we could recover a substantial fraction of YFP^+^ Treg cells from the periphery of *Foxp3*^*Cre/+*^*Hoip*^*fl/+*^ control mice, very few YFP^+^ Treg cells were detected in *Foxp3*^*Cre/+*^*Hoip*^*fl/fl*^ females ([Supplementary Fig. 5f,g](#S1){ref-type="supplementary-material"}). Treg cell loss in *Hoip*^ΔFoxp3^ mice could not be rescued by repeated anti-TNF treatment of neonatal mice commencing from day 5 (data not shown), suggesting that this defect was not caused by excessive TNF-induced cell death. These findingsMany consumers have difficulty obtaining a fantastic Dentist in Barbelroth, but with the proper attitude you can acquire one who is skilled in all types of dental function and will be able to deliver care for you and your entire family.

Affordable dentist in Barbelroth may be just as good in skill and just as equipped as the higher priced offices, so make sure you don't negate a dental team because you feel they are too inexpensive. Dental Hospital who are skilled in their profession having a very good reputation will generally times be booked for a whilst, so if you have to wait for a couple of weeks it may be worth it because of the top quality of function you will receive.

Whenever you are looking for a


sole plaintiff and there was no prejudice to defendants, the district court should have granted McCurdy's motion to amend his complaint to include his signature.  See Price v. United States Navy, 39 F.3d 1011, 1015 (9th Cir.1994) (excusing pro se appellant's initial failure to sign notice of appeal).

16
REVERSED AND REMANDED.

*
 The panel unanimously finds this case suitable for decision without oral argument.  Fed.R.App.P. 34(a);  9th Cir.R. 34-4

**
 This disposition is not appropriate for publication and may not be cited to or by the courts of this circuit except as provided by 9th Cir.R. 36-3

1
 Because McCurdy's October 17, 1990 burglary conviction was vacated before he filed his section 1983 action, see In re McCurdy, No. DO14915 (Cal.Ct.App. filed Jan. 29, 1992) (granting McCurdy's habeas petition),the circuit court's findings, as set forth in its order and judgment, are clearly against the preponderance of the evidence.
III. Presentation of Additional Evidence
For its second point on appeal, the City of Van Buren contends that it was error for the circuit court to admit into evidence testimony concerning events that occurred prior to January 27, 1999. Specifically, Van Buren asserts that such evidence is irrelevant to the issue of whether Mr. Smith's employment was properly terminated because of his behavior on January 27, 1999. Van Buren further argues that Mr. Smith waived his right to present additional evidence and should have been estopped from doing so because, at the hearing before the commission, he argued that no evidence of events preceding January 27, 1999, should be introduced.
The


any irreducible polynomial $an^2+bn+c$ with $a>0$ and $c$ odd.

The results mentioned in the last two paragraphs were based on sieve methods. It is also note-worthy that J. B. Friedlander and H. Iwaniec [@FrIw2], using results on half-dimensional sieve of H. Iwaniec [@HIwan], obtained lower bounds for the number of integers with no small prime divisors represented by a quadratic polynomial.

J. B. Friedlander and H. Iwaniec [@FrIw] also proved the celebrated result that there exist infinitely many primes of the form $m^2+n^4$ (with an asymptotic formula). The set of integers of the form $m^2+n^4$ contains the set of integers of the form $m^2+1$ but is still very sparse. The number of such integers not exceeding $x$ is $O(x^{3/4})$. It is generally very difficult to detect primes in sparse sets.

Inthe wafer stage 1 by irradiating a laser beam in parallel with the X-axis onto an X-bar mirror 3 and causing the incoming reflected light to interfere with reference light. Position measurement of the wafer stage 1 in the Y-axis direction is performed in the same manner. By positioning either one of or both of the laser interferometer 5 and a laser interferometer 4 for the X- and Y-axes, the rotational angle θ around the Z-axis of the wafer stage 1 also can be detected.
On the basis of the positional information obtained by the laser interferometers 5 and 4, by arranging actuators (not shown in the figures), such as linear motors, etc., in two dimensions, the wafer stage 1 can be driven to a predetermined position.
When the wafer


burning, injury by shock or release of toxic fumes. For example, aging or mechanically damaged electrical insulation results in local shorts and overheating due to large currents. Another frequent cause of overheating in electric motors is mechanical overload or stalling resulting in excessive current. Electrical or electronic devices which are fan or conduction cooled will overheat if the cooling medium or transport method fails. A safe, reliable and inexpensive safety device is needed to sense dangerous electrical conditions such as overheating and mechanical damage which threaten life and property.
Numerous devices for sensing over temperature conditions have been previously disclosed and claimed. Up to now, these safety devices have not enjoyed widespread use due to cost, complexity, electrical or mechanical limitations as well as safety concerns for the deviceto switch over to this model soon.This paid subscription model will take effect the first week of April, with IPL4 being the first of our events to be covered by it. All of our streams will continue to be free in all resolutions until IPL4.Thank you very much for your continued support and please leave any questions or comments here, we read every post!Also, just to reiterate, live qualifier competitor passes are going quickly: http://ipl4sc2.eventbrite.com/ And for live event spectator passes, we have a 50% off discount promotion running on our Facebook (try multiple browsers or disabling Adblock if you have trouble seeing the promotion): http://www.facebook.com/IGNProLeague?sk=app_211922635540356


Chris Cox captures his third Road to the Horse title and is named the first Legends of Colt Starting Champion. It was without a doubt the most electrifying event in the eight-year history of Road to the Horse; The World Championship of Colt Starting…MoreNeighborhood Information

Your browser does not support iframes.

School Information

Your browser does not support iframes.

Courtesy of Long & Foster Real Estate INC.

All information deemed reliable but not guaranteed and should be independently verified. All properties are subject to prior sale, change or withdrawal. Neither listing broker(s) nor Keller Williams Realty West Monmouth shall be responsible for any typographical errors, misinformation, misprints and shall be held totally harmless. IDX information is provided exclusively for consumers, personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. All listings displayed pursuant to IDX shall show the MLS as the source of the information.


minator of p and -29/18.
18
Suppose -96 = -2*k - 4*k. What is the lowest common multiple of k and 56?
112
Let w(o) = o**3 - 4*o**2 - o + 22. Calculate the smallest common multiple of 56 and w(4).
504
Let i(m) = 4*m - 5. Suppose 3*p + 2*p - 50 = -5*a, -3*a + 5*p = -38. What is the smallest common multiple of a and i(3)?
77
Let i = 456941/64 - 7140. Calculate the common denominator of i and -119/12.
192
Let h be 34/(-2) + (3 - 6). Find the common denominator of 19/2 and (-6)/(-15) + (-134)/h.
10
Let u = 34303866/473 - 72524. Let b = u + 36253/5676. Find the common denominator of -85/16 and b.
48
Let o = -1278 + 11462/9. What is the common denominator of -36 and0 = 3*m - 7 + 4. What is the lowest common multiple of 21 and m?
21
Calculate the least common multiple of 34 and (2/(-5))/((0 + -2)/30).
102
Let n = 8 - 0. What is the smallest common multiple of n and (4/5)/(10/75)?
24
What is the lowest common multiple of 21 and 9/(-27) + 128/6?
21
Let n(z) = 28*z - 3. Let y be n(-3). Let v = -14/345 + 3547/690. Find the common denominator of v and y/(-10) + (-1 - -4).
10
Let w(u) = -u**2 + 4*u - 4. Let r be w(5). Find the common denominator of 29/2 and 4/8*r/(-12).
8
What is the lowest common multiple of -1*(-15 - -4 - -3) and 11?
88
Let a(w) = 17*w**2 - 3*w - 2. What is the smallest common multiple of a(-1) and


-s + 216 = 4*u, -2*s - 4*u + 17 = -403. Calculate the smallest common multiple of s and 16.
816
Suppose 5*c + 10 = -5*q, -27 + 7 = -5*c. Let w = q + 8. What is the least common multiple of 14 and w?
14
Let i = -8 - -28. What is the least common multiple of 20 and i?
20
Suppose 0*s = -r - 3*s - 3, s + 22 = 2*r. Calculate the smallest common multiple of 18 and r.
18
Let n be (-7206)/(-45) + (-1)/3. Let t = n + -158. Calculate the common denomina+ 8.8. What is the second smallest value in b, 2/9, 2/7?
2/7
Let w = -0.271 + 139.271. Let k = 139.3 - w. Let q = 4 - 9. Which is the second biggest value?  (a) 2  (b) k  (c) q
b
Let i = -0.4 - -4.4. Let f = i - 1. Let z = 0.13094 - 0.02094. What is the second biggest value in 0.5, z, f?
0.5
Let q = 3.7 + -2.7. What is the second biggest value in -0.3, q, 0, 0.2?
0.2
Let o be (-27)/(-18)*2/18*-2. Let n = -0.9 + 0.93. What is the smallest value in o, -0.4, n?
-0.4
Let f be ((-306)/(-340))/(3/2). What is the smallest value in f, -5, -2, 0.64?
-5
Suppose -2*g + g = 3. Let o be 1 -


ADVERTISEMENT

Senior market analyst at eToro Mati Greenspan says long-term Bitcoin hodlers may be getting into altcoin season, investing in coins with smaller market caps as the price of Bitcoin stays in limbo.

“I’ve been tweeting about alt season for a few weeks already. At the moment, while Bitcoin is kind of standing still some of the altcoins are outperforming. Litecoin has done very well because it has a very large community base and there’s a halving event coming up in August. And Binance Coin has been doing very well as well. And then we have these days where some altcoins will go up double digits. They’re basically taking turns and each day there’s like a winner of alt season that I’ve been tweeting out as well.”

In a newtwo years, charges Rs 170,000. Ajay (name changed) said, "You will get your PhD from Monad University, Hapur (Uttar Pradesh) within two years and you can go for classes as per your convenience. We will also provide help in your examinations and can get you a readymade thesis if you want."


the victory from the inside out. He wants us to “stand strong in the Lord and the power of His might” with an internal confidence in God. How we stand in the Lord’s power will come clearer as we proceed on this journey. Just remember what you have learned to this point. The Holy Spirit has given us God’s precious thoughts in Psalm 139 and now He wants us to receive it, believe it and obey it. This is the only path the world, sin, and Satan will be defeated in our lives.

Observation: David sees the wickedness around him and he responds in the spiritually normal way of wanting freedom and change. His first two responses to the realization he needs change are typical and non-productive. David wasthe comeback with two tries along with talisman Vic Leeuw who scored three second half tries of his own to help the Jets finally re-take the lead with only one minute to play. But the Vikings still had a final effort in them and, riding the back of an opportune penalty, passed the ball to Petr Sedina who managed to get over the line just as the final whistle sounded, giving the Vikings a last gasp four point victory in front of the crowd of almost 100 engaged onlookers! For full match statistics see: http://rugbyleague.cz/utkani/jets-pardubice-v-vikings-praha/2012-06-23/111132.


satisfied" with the symptom state 12 months postoperatively. Sensitivity analyses were carried out for various subgroups (sex, age, pathology, comorbidity status, smoking status, preoperative pain level, previous surgery, type of health insurance, and time of follow-up [3 and 24 months]). The study was funded by the Schulthess Klinik Research Funds; there were no potential conflict of interest-associated biases for any of the authors. Of 6,943 patients, 6,248 (90%) returned a 12-month questionnaire, of which 47% reported being at least somewhat satisfied with their symptom state (52% [DH], 45% [SS], 53% [DS], 44% [DegDef], 45% [DegSeg], and 44% [others]). The areas under the curve for the ROCs were 0.89 to 0.91 for the different pathologies, indicating a good ability of the pain score to discriminate between being in a3.8 the kinetics becomes much faster, with the faster and slower components accelerating by factors of about 8 and 2, respectively. Complementary single-flash absorption experiments at 380 nm and 10 degreesC show that the formation of MII also occurs with two components with similar time constants and pH dependence. This suggests that both signals monitor the same molecular events. The pH dependence of the two apparent time constants and amplitudes of the optical data can be described well over the pH range 4-7.5 by two coupled equilibria between MI and two isochromic MII species MIIa and MIIb: MI MIIa(380) MIIb(380), with k0 proportional to the proton concentration. This model implies that deprotonation of the Schiff base and proton uptake are tightly coupled in ROS membranes. Models with k2


Use of heating or energy radiating devices, particularly microwave radiating devices, to administer heat for the treatment of various diseases of the prostate have been demonstrated to provide efficacious treatment of various prostate conditions (Devonec et al., Monographs in Urology, 13, 77–95 (1992); De La Rosette et al., J. Urology, 157, 430–438 (1997); Devonec et al., J. Endourology, 5, 129–135 (1991); Bernier et al., Curr. Opin. Urol., 7, 15–20 (1997)). Research has indicated that the cellular transformations brought about by raising tissue temperatures above certain levels can be used therapeutically. At temperatures above 45° C., thermal damage has been found to occur to cells, even when the exposure to the elevated temperatures lasts for even a short period of time. Thermal therapy has been defined as the processsuperficial treatment of the prostatic tissue.
A more preferred method to deliver thermotherapy in the context of the present invention is via a urethrally-inserted catheter with an imbedded microwave antenna. A cooling device is typically incorporated into microwave emitting catheters so that urethral tissue proximal to the microwave antenna is cooled. The addition of this feature has been directed at preserving the prostatic urethra, thereby reducing treatment discomfort and post-treatment recovery time. A temperature or energy measurement device can be used during treatments so that a thermal dose can be measured. Treatments utilizing this approach include TransUrethral Microwave Thermotherapy (TUMT). One disease currently treated by TUMT is Benign Prostatic Hyperplasia (BPH). The therapeutic effect of such therapies can be measured in any suitable manner. For example, therapy can be


have not incorporated the more advanced features of the present invention. Other catheter designs useful in the context of the present inventive system have been commercially developed, e.g., by EDAP/Technomed and Urologix. While these other catheter designs are well known in the art, other examples are disclosed, e.g., by U.S. Pat. Nos. 4,620,480 and 5,628,770.
In view of the foregoing problems, there is a need for prostatic thermotherapy, particularly for BPH that is cost-effective, eliminates the use of general anesthesia and obviates the need for a cooled catheter. There is also a need for a prostatic thermotherapy that reduces non-beneficial side effects of previous methods.
The present invention provides such a method and related devices. These and other advantages of the present invention, as well as additional inventive features, willportions of the test materials will be developed and refined. Once the appropriate formats have been finalized, normative performance data in the form of auditory psychometric functions will be obtained using Spanish speakers as subjects. A successful computer-based approach for speech acuity tests involving a simple language-to-place transformation on a computer monitor is a major technological innovation over the traditional paper-and-plastic medium.


"No, you weren't." "She's had to stay with her grandparents while Michelle and I try to flush out the Sidorov thing." "I want this to be special, G." "Kensi and Deeks are dressing up." "You were coming to her birthday party anyway, right?" "Not dressed as a werewolf." "It's not a werewolf, it's Professor Lupin." "You said it was a werewolf." "Wait, Lupin sounds like a werewolf." "Technically, yes, but only during a full moon." "This is afternoon." "I mean, if anyone's gonna go as a werewolf, it should be Deeks." "The guy's halfway there already." "All you got to do is wear a robe, carry a wand." "For my little girl?" "Please, Uncle Callen?" "Fine." "But you owe me big-time." "Just be glad she's out of hertechnology that we have to scour the planet for footage of you performing." "Okay, now you're scaring me." "Dance, monkey, dance." "Possessed much?" "Okay." "I'm just gonna text Callen and Sam." ""Hey, guys, did you know that..."" "Stop texting, fine." "That's" " I-I will sing." "Stop texting." "I will sing." "You want me to sing, I'll sing." "You want me to dance, I'll be your monkey." "Here we go." "Bup-bup-bup." "You ready for it?" "Oh, I'm ready." "Is this really necessary?" "Action." "♪ Baby!" "♪ Baby... ♪ Me-me-me-me-me, gee-gee-gee-gee-gee-gee-gee ♪" "♪ Baby!" "Nope, sometimes, you got to really breathe from the diaphragm;" "it's important." "It's been a long time since I really blasted out the pipes, so I just..." "Oh, God, wow." "Hi, how are you?" "What can


this is not ice dancing." "Just lift me up." "I mean, maybe you could hand me a leg or something to hold on to." "Just put your leg up." "Just put your-- yeah, there you go." "Right like... that." "Um..." "Maybe you should grab the other one." "She's a lot heavier, actually, than she looks." "It's all that very dense muscle mass from pole dancing." "That she does." "Yeah." "He's kidding." "I'm not really kidding." "I almost lost my appendix the last time she tried to do the Hungarian bicycle." "It was crazy." "On three." "On three." "One, two..." "Three." "Ho!" "Wish me luck." "Uh, good luck." "Yeah, I'm gonna need it." "And congratulations." "Okay." "Thank you." "Congratulations to us." "Put me down." "You laugh funny and youryour interpretation." "Why?" "Nell is the analyst." "I'm just a technical operator." "I'm just a techie." "I find data, I steal data," "I decrypt data, I do not analyze data..." "Eric, what did you find?" "Nothing... exactly." "It's just that... her past seemed surprisingly similar to some other agents." "What other agents?" "Sullivan, Hunter... you." "You hiding in here?" "No." "Just looking for a little peace and quiet so I can concentrate." "You guys find Vandenberg?" "Not yet." "You good?" "Don't I seem good?" "You seem a little off your game." "Would you have made a different call at the hotel?" "Maybe." "Doesn't mean it would've been the right one." "What's going on?" "Nothing." "You're worried about getting dressing up for the birthday party?" "Yeah, that's what it


Cheap shots

I agree it's a cheap shot to attack Romney for engaging a sport he enjoys. Just like it was cheap shot for Republicans to attack Kerry for wind surfing & it was for liberals to attack Ike for golfing and it is for Republicans to attack Obama for the same.

Note: Comments are moderated by the editor and are subject to editing.injuries: The fire chief later said there were two injuries: a firefighter who was hurt when debris fell on top of him, and an engineer who was injured but refused treatment. A civilian was also injured but details were not immediately available.

Let our news meet your inbox. The news and stories that matters, delivered weekday mornings. This site is protected by recaptcha

A fire broke out at Trump Tower on Fifth Avenue in New York City on Jan. 8, 2018. @levi1994

More than 70 firefighters responded to the call, a standard number for fire on the roof of a high rise, the NYPD told the Associated Press.

Smoke could be seen wafting off the roof of Trump Tower, but the fire started dissipating within a half hour, witnesses posting photos on


Q:

How to solve the problem of Flutter hot reload

My flutter project is working properly on my android device. When I delete default code and save then hot reload is not working. It does not show any error at the terminal. I am using vs code editor and connected via data cable.

A:

The most common causes for hot reload appearing not to work are things like modifying your main method (hot reload does not re-run this). Check what you're doing against the limitations listed in the docs at https://flutter.dev/docs/development/tools/hot-reload
Things that don't hot reload include:

static fields
changes to main method
changes to initState
enums changed to classes and vice-versa
generic type args modified

of cohabitation

Congo is heading for an “inevitable period of cohabitation” between the movements led by Tshisekedi and Kabila, Infrastructure Minister Thomas Luhaka, who is an FCC member, told Bloomberg in an interview on Friday.

Fayulu accuses Tshisekedi of having sealed a secret agreement with Kabila in order to obtain the presidency – a charge the president elect’s camp strongly denies.

Leaders of DRC “might want to consider” a government of national unity, according to South African foreign minister Lindiwe Sisulu at a press conference today. She says she is not “pushing” the idea, but she emphasizes that it worked in South Africa in the past.

CENI and the government have rebuked CENCO both disputing the accuracy of its claims and accusing the institution of overstepping its responsibilities in a manner which


have also stood behind Charney’s charge.

“An education campaign focused on this would be a fantastic new initiative,” said Ken Carlson, chairman of the advisory group. “It would really have an impact. Let’s see where we can take this.”

So will drivers go Dutch? Charney hopes so.

“My campaign is to get Americans to do what the Dutch have been doing for a long time,” he said. “It makes total sense, and it becomes automatic.”

Steve Annear can be reached at steve.annear@globe.com. Follow him on Twitter @steveannear.2010 and January 2013 were prospectively analyzed. Patients were followed up for at least 6 months. Mode of surgery, histopathology, morbidity and mortality were evaluated. Twenty-six patients had a carcinoma of transverse colon, 16 patients one of hepatic flexure and four patients one of splenic flexure. The median lymph node yield was 40. Occurrence of lymph node metastasis in ILR was registered in five patients and in GLR in four patients. The mean lymph node ratio was 0.085. Postoperative complications occurred in nine patients, and postoperative mortality was 2 %. We were able to demonstrate this novel metastatic route of carcinomas of the transverse colon and of both flexures in ILR and GLR. These could be considered as regional lymph node regions and have to be included into


Perspectives on Epidermal Growth Factor Receptor Regulation in Triple-Negative Breast Cancer: Ligand-Mediated Mechanisms of Receptor Regulation and Potential for Clinical Targeting.
Currently, there are no effective targeted therapies for triple-negative breast cancer (TNBC) indicating a critical unmet need for breast cancer patients. Tumors that fall into the triple-negative category of breast cancers do not respond to the targeted therapies currently approved for breast cancer treatment, such as endocrine therapy (tamoxifen, aromatase inhibitors) or human epidermal growth factor receptor-2 (HER2) inhibitors (trastuzumab, lapatinib), because these tumors lack the most common breast cancer markers: estrogen receptor, progesterone receptor, and HER2. While many patients with TNBC respond to chemotherapy, subsets of patients fare poorly and relapse very quickly. Studies indicate that epidermal growth factor receptor (EGFR) is frequently overrepresented in TNBC (>50%),    * @return local registry
     */
    public static RegistryConfig getDefaultRegistryConfig() {
        RegistryConfig local = new RegistryConfig();
        local.setRegProtocol("local");
        return local;
    }

    public static String removeAsyncSuffix(String path) {
        if (path != null && path.endsWith(MotanConstants.ASYNC_SUFFIX)) {
            return path.substring(0, path.length() - MotanConstants.ASYNC_SUFFIX.length());
        }
        return path;
    }

    public static DefaultResponse buildErrorResponse(Request request, Exception e) {


wearing dark glasses, and that a person could have thought that she was asleep. She said that after some conversation between Killingsworth and Wilson, Killingsworth said to the officer, "Get up and give the girl your money. You want the stuff, why don't you get up and give the girl your money?" She also testified that when the defendants returned the defendant Wilson handed her the package containing heroin while Ruth Killingsworth was talking on the telephone.
The defendant Wilson testified that she had known Ruth Killingsworth for nine or ten years, and considered her a good friend. The two women patronized the same dressmaker and had gone out socially together. On many occasions the defendant had loaned her money. Killingsworth had been a narcotics addict for seven orproject. The goal of the project was to tell a visualization story. We could choose any data set we want.

Having tons of experience at work with Tableau, I would say I am tapped into that community. At least enough to be aware of #MakeoverMonday. For all 52 weeks of the year, a data set is posted by Eva Murray or Andy Kriebel with a challenge to give it a makeover. Can you guess what day they share it on?

This is great for people who are aspiring data scientists and want to work on data viz. This is also great for lazy people who want to quickly find a data set for their school project.

It was this very week where they analyzed James Patterson’s checkout records from Seattle's public