within the day in which participants had higher or lower levels of pain, which could be attributed to medication intake, stressors or adequacy of sleep \[[@CR29]\].

This study has some limitations. Firstly, the study had a low response rate and was limited to well educated, Caucasian, older adults, which is to a great extent inherent in the fact that the sampling frame was retired teachers and their dependents. This limits the generalizability of these results to other arthritis populations that may be different from this sample. Second, the Canadian value set was used for calculating the EQ-5D-5 L index score, while the UK value set was used for the SF-6D index score. It is possible that the UK general population has different valuations of health from the Canadian general population.

The Dark Side of Scala - lauriswtf
http://nurkiewicz.github.io/talks/2014/scalar/?utm_content=bufferaef95&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer#/

======
A1kmm
Scala is a powerful language - it has lots of ways to make really nice
embedded DSLs, but you can also write obfuscated code that doesn't behave
intuitively in it (as with many languages).

To explain the behaviour of some of the non-intuitive things in the slides:

      * List(1,2,3).toSet()    This is asking is () i.e. Unit a member of the Set(1,2,3) - the answer is false. List((),1,2,3).toSet() is true. The programmer probably wanted List(1,2,3).toSet.
      * The val code on slide 6 throws a null pointer exception because triple isn't initialised by the time it is evaluated. Languages like Haskell where order isn't important are


                0x02);                /* length   */
    if(req_status != USBH_BUSY)
    {
      AUDIO_Handle->cs_req_state = AUDIO_REQ_CS_IDLE;
      AUDIO_Handle->headphone.attribute.resolution = LE16(&AUDIO_Handle->mem[0]);
    }
    break;

  case AUDIO_REQ_CS_IDLE:
    status = USBH_OK;
  default:
    break;
  }
  return status;
}

/**
  * @brief  USBH_AUDIO_HandleCSRequest
  *         The function is responsible for handling AC Specific requests for a          AUDIO_Handle->temp_channels);

  if(cs_status != USBH_BUSY)
  {

    if(AUDIO_Handle->temp_channels ==  1)
    {
        AUDIO_Handle->temp_feature = AUDIO_Handle->headphone.asociated_feature;
        AUDIO_Handle->temp_channels = 0;
        status = USBH_OK;
    }
    else
    {
      AUDIO_Handle->temp_channels--;
    }
    AUDIO_Handle->cs_req_state = AUDIO_REQ_GET_VOLUME;
#if (USBH_USE_OS == 1)
      osMessagePut ( phost->os_event, USBH_URB_EVENT, 0);
#endif
  }

  return status;
}

/**
  * @brief  USBH_AUDIO_Process
  *


USBH_FAIL ;
  AUDIO_HandleTypeDef *AUDIO_Handle;

  AUDIO_Handle =  phost->pActiveClass->pData;

  /* Look For AUDIOCONTROL  interface */
  interface = USBH_FindInterface(phost, AC_CLASS, USB_SUBCLASS_AUDIOCONTROL, 0xFF);
  if(interface != 0xFF)
  {
    for (interface = 0;  interface < USBH_MAX_NUM_INTERFACES ; interface ++ )
    {
      if((phost->device.CfgDesc.Itf_Desc[interface].bInterfaceClass == 0x03)&& /*HID*/
        (phost->device.CfgDesc.Itf_Desc[interface].Ep_Desc[0].wMaxPacketSize > 0))
      {
        if((phost->device.CfgDesc.Itf_Desc[interface].Ep_Desc[0].bEndpointAddress & 0x80) == 0x80)
        {
          AUDIO_Handle->control.Ep = phost->device.CfgDesc.Itf_Desc[interface].Ep_Desc[0].bEndpointAddress;
          AUDIO_Handle->control.EpSize = phost->device.CfgDesc.Itf_Desc[interface].Ep_Desc[0].wMaxPacketSize;

  AUDIO_Handle =  phost->pActiveClass->pData;

  /*Find microphone IT*/
  for(terminalIndex = 0; terminalIndex < AUDIO_Handle->class_desc.InputTerminalNum; terminalIndex++)
  {
    if(LE16(AUDIO_Handle->class_desc.cs_desc.InputTerminalDesc[terminalIndex]->wTerminalType) == 0x201)
    {
      UnitID = AUDIO_Handle->class_desc.cs_desc.InputTerminalDesc[terminalIndex]->bTerminalID;
      AUDIO_Handle->microphone.asociated_channels =  AUDIO_Handle->class_desc.cs_desc.InputTerminalDesc[terminalIndex]->bNrChannels;
      break;
    }
  }

  do
  {
    value =  USBH_AUDIO_FindLinkedUnit(phost, UnitID);
    Index = value & 0xFF;
    Type   = (value >> 8) & 0xFF;
    UnitID   = (value >> 16) & 0xFF;

    switch (Type)


* @param  length: total length of the audio data
  * @retval USBH Status
  */
USBH_StatusTypeDef USBH_AUDIO_Play (USBH_HandleTypeDef *phost, uint8_t *buf, uint32_t length)
{
  USBH_StatusTypeDef Status = USBH_FAIL;
  AUDIO_HandleTypeDef *AUDIO_Handle;

  if(phost->gState == HOST_CLASS)
  {
    AUDIO_Handle =  phost->pActiveClass->pData;
    if(AUDIO_Handle->play_state == AUDIO_PLAYBACK_IDLE)
    {
      AUDIO_Handle->headphone.buf = buf;
      AUDIO_Handle->headphone.total_length = length;
      AUDIO_Handle->play_state = AUDIO_PLAYBACK_PLAY;
      AUDIO_Handle->control_state = AUDIO_CONTROL_INIT;
      AUDIO_Handle->processing_state = AUDIO_DATA_START_OUT;
      Status = USBH_OK;
    }
  }
  return Status;
}

/**
  * @brief  USBH_AUDIO_Pause
  *    *         return the current buffer pointer for OUT proces
  * @param  phost: Host handle
  * @retval USBH Status
  */
int32_t USBH_AUDIO_GetOutOffset (USBH_HandleTypeDef *phost)
{
  AUDIO_HandleTypeDef *AUDIO_Handle;

  if(phost->gState == HOST_CLASS)
  {
    AUDIO_Handle =  phost->pActiveClass->pData;
    if(AUDIO_Handle->play_state == AUDIO_PLAYBACK_PLAY)
    {
      return AUDIO_Handle->headphone.partial_ptr;
    }
  }
  return -1;
}

/**
  * @brief  USBH_AUDIO_ChangeOutBuffer
  *         Change audio data buffer address
  * @param  phost: Host handle
  * @param  buf: buffer address
  * @retval USBH Status
  */
USBH_StatusTypeDef USBH_AUDIO_ChangeOutBuffer (USBH_HandleTypeDef *phost, uint8_t


if(AUDIO_Handle->headphone.attribute.volume < AUDIO_Handle->headphone.attribute.volumeMin)
  {
    AUDIO_Handle->headphone.attribute.volume =AUDIO_Handle->headphone.attribute.volumeMin;
  }

  if(AUDIO_SetVolume (phost,
                                 AUDIO_Handle->temp_feature,
                                 AUDIO_Handle->temp_channels,
                                 AUDIO_Handle->headphone.attribute.volume) != USBH_BUSY)
  {

   if(AUDIO_Handle->temp_channels ==  1)
    {
      AUDIO_Handle->temp_feature  = AUDIO_Handle->headphone.asociated_feature;
      AUDIO_Handle->temp_channels = AUDIO_Handle->headphone.asociated_channels;
      status = USBH_OK;
    }
    else
    {
      AUDIO_Handle->temp_channels--;
    }
    AUDIO_Handle->cs_req_state = AUDIO_REQ_GET_VOLUME;
  }

  return status;
}

/**
  * @brief  USBH_AUDIO_SetVolume
  *         Set Volume
  * @param  phost: Host handle
  * @param  volume: VOLUME_UP/ VOLUME_DOWN
  * @retval USBH Status
  */
USBH_StatusTypeDef USBH_AUDIO_SetVolume (USBH_HandleTypeDef *phost, AUDIO_VolumeCtrlTypeDef volume_ctl)
{
  AUDIO_HandleTypeDef *AUDIO_Handle = phost->pActiveClass->pData;

  if((volume_ctl == VOLUME_UP) || (volume_ctl


Q:

C90 doesn't allow %lf use in printf, why?

I'm a beginner programming student, just wanted to learn the reason behind this.
When I use this code:
#include <stdio.h>
int main()
{
 double pi = 3.1415926535897932;
 printf("%lf",pi);
 return 0;
}

Compiler gives this warning.
ISO C90 does not support the ‘%lf’ gnu_printf format [-Wformat]
I use the gcc compiler in ubuntu terminal with (-o -Wall -ansi -pedantic-errors)
What's the reason behind this? I searched web and found this use is allowed in C99. Why C90 didn't allow %lf use in printf? I can use %.16lf or %.16f and both print with the same precision, so what's the matter that makes %lf bad in C90?

A:

According to C90 documentation:

an optional l (ell) specifying that a following d , i , o , u , x , or
  X conversion6:
            document.getElementById("hours").innerHTML="Closed Today";
            break;
    }
} else if (date_formatted >= '5/2/1') {         //begin May intercession
    switch (weekDay)            {
        case 0:
            document.getElementById("hours").innerHTML="Closed Today";
            break;
        case 1:


           break;
        case 1:
        case 2:
        case 3:
        case 4:
            document.getElementById("hours").innerHTML="Today's Hours: 7:30AM to 10:00PM";
            break;
        case 5:
            document.getElementById("hours").innerHTML="Today's Hours: 7:30AM to 4:00PM";
            break;
        case 6:
     corrected for Fbackground.

Immunoblotting
--------------

Hearts freshly excised from wild‐type and Rad^−/−^ mice (Figure [11](#fig11){ref-type="fig"}C) or perfused on a Langendorff apparatus (Figure [6](#fig06){ref-type="fig"}D) were flash frozen, and tissue was pulverized under liquid nitrogen before homogenization in cell lysis buffer containing 20 mmol/L HEPES, pH 7.4, 50 mmol/L KF, 50 mmol/L β‐glycerol phosphate, 150 mmol/L NaCl, 2 mmol/L EGTA, pH 8.0, 0.5% Triton X‐100, 10% glycerol, 2 mmol/L Na3VO~4~, and 1× protease inhibitor cocktail (Calbiochem). Lysates were centrifuged at 13 000 rpm, and the protein concentrations of the supernatants were measured. Lysates were prepared in 4× SDS‐PAGE loading buffer, and 30 μg total protein per lane was resolved on 15% SDS‐PAGE gels and transferred to nitrocellulose membranes. Phospholamban phosphorylation levels were measured by immunoblotting with phospholamban phospho‐serine 16 (1:5000, Badrilla), phospho‐threonine 17


supraventricularly paced throughout the study at a rate slightly higher than the intrinsic rate. Left ventricular pressure, cardiac output, and coronary flow were measured once the heart had reached steady state. To examine the effects of β‐adrenergic stimulation, isoproterenol (10 nmol/L) was added to the perfusate, and after reaching steady‐state, the same functional parameters were measured.

Results
=======

Rad Deletion Increases I~Ca,L~ and Predicted Window I~Ca,L~
-----------------------------------------------------------

Rad overexpression profoundly inhibits I~Ca,L~ in heterologous expression systems.^[@b9]^ However, our recent findings in Rem^−/−^ cardiomyocytes show that LTCC voltage dependence is shifted positive, suggesting that physiological expression levels of RGK proteins may act to fine‐tune I~Ca,L~.^[@b12],[@b17]^ To examine the contribution of Rad to LTCC function, we measured I~Ca,L~ in mature Rad^−/−^ cardiomyocytes. [Figure 1](#fig01){ref-type="fig"}A shows representative I~Ca,L~ traces. There is a robust persistent inward I~Ca,L~had no effect on Rad^−/−^ spontaneous Ca^2+^ transients. n=37 cells (5 mice) for WT, n=36 cells (8 mice) for Rad^−/−^, n=11 cells (3 mice) for WT+ISO, n=16 cells (3 mice) for Rad^−/−^+ISO. G, In Rad^−/−^ cells, tau (τ), a measure of calcium re‐uptake kinetics, responded significantly to ISO, similar to WT cohorts n=12 cells (3 mice) for WT, n=18 cells (3 mice) for Rad^−/−^. \**P*\<0.05, \*\**P*\<0.01,\*\*\**P*\<0.001 vs WT. Error bars represent SEM. NS indicates not significant, V~½~, activation midpoint; I~Ca,L~, L‐type calcium channel; PKI, protein kinase I.](jah3-2-e000459-g9){#fig09}

Absence of Rad Increases Developed Pressure and Blunts β‐Adrenergic Responsiveness
----------------------------------------------------------------------------------

At the isolated cell level, sarcomeric shortening in Rad^−/−^ without agonist stimulation is also indistinguishable from that of isoproterenol‐stimulated wild‐type cardiomyocytes ([Figure 9](#fig09){ref-type="fig"}E). This suggests functional changes at the whole heart level. Rad^−/−^


cellular finding underpins the significantly enhanced contractility of intact Rad^−/−^ hearts. Taken together, these results are consistent with the new provocative hypothesis that β‐adrenergic signaling of contractile Ca^2+^ functions in part via disinhibition of Rad‐I~Ca,L~ function.

Relationship to Previous Studies of Rad in the Heart
----------------------------------------------------

The present work is the first to evaluate the electrophysiological and contractile mechanisms responsible for Rad‐deletion--induced alterations in myocardial function. Our work builds on results from 3 previous studies exploring Rad contributions to cardiomyocyte function. Two studies used overexpression of Rad or Rad mutants.^[@b13],[@b20]^ Overexpression of a dominant negative form of Rad showed a hyperpolarized shift of the LTCC activation curve consistent with our results.^[@b21]^ Only one study known to us considers Rad^−/−^ mice,^[@b14]^ which examines hypertrophic growth but leaves open the question of theGet over 50 fonts, text formatting, optional watermarks and NO adverts! Get your free account now!

The only time my mum and I bond - Is when we bitch about my brothers fiance and her kid

Check out all our blank memes


for review of the Commissioner's determination.  However, the Tax Court largely adopted the Commissioner's valuations and concluded that Nestle had realized a capital gain.  Nestle appeals.  We agree that Nestle realized a capital gain but reject the Tax Court's relief-from-royalty method of determining the fair market value of Nestle's trademarks.

BACKGROUND

3
This dispute arises from a tender offer by Nestle for the stock of Carnation Company.  Nestle's initial plan was to finance its acquisition of Carnation with a capital contribution of $525 million from NSA and a $2.5 billion loan from outside sources.  Ultimately, this plan was revised, and the acquisition was financed by commercial loans of $1.6 billion and related-party loans of $1.325 billion.  NSA provided some of these related-party loans but made(quoting Federal Bulk Carriers, Inc. v. Commissioner, 558 F.2d 128, 130 (2d Cir.1977));  Estate of Durkin v. Commissioner, 99 T.C. 561, 574-75, 1992 WL 335900 (1992).  The Commissioner, on the other hand, is not required "to acquiesce in the taxpayer's election of that form" but may challenge the chosen form as a sham.  Higgins, 308 U.S. at 477, 60 S.Ct. 355;  see also Newman v. Commissioner, 902 F.2d 159, 162-63 (2d Cir.1990).

14
The chosen form of the transaction between Nestle and NSA was a sale of assets.  The Tax Court found that this choice of form was not a sham, and the Commissioner does not argue otherwise.  Accordingly, because the NSA transaction was structured as a sale, any gain realized by Nestle must


power.

The project will be a chance to develop the touristic activity in Sinai and Suez Canal Area Development Project said Egyptian Minister of Investment, Sahar Nasr.

NEOM is situated in one of the world’s most prominent economic arteries, through which nearly a tenth of the world’s trade flows. It spans over 26,500 km2, overlooking the waterfront of the Red Sea to the South and the West, and the Gulf of Aqaba, enabling 70 percent of the world’s population to reach it in under eight hours.

Edited Translation from Al-Masry Al-Youmdiscussed with their achievements, challenges and limitations. In \[[@B8-sensors-19-01313],[@B9-sensors-19-01313],[@B10-sensors-19-01313],[@B11-sensors-19-01313],[@B12-sensors-19-01313],[@B13-sensors-19-01313],[@B14-sensors-19-01313],[@B15-sensors-19-01313],[@B16-sensors-19-01313],[@B17-sensors-19-01313],[@B18-sensors-19-01313],[@B19-sensors-19-01313],[@B20-sensors-19-01313],[@B21-sensors-19-01313]\], the energy efficient routing protocols are proposed. In the papers \[[@B8-sensors-19-01313],[@B10-sensors-19-01313],[@B11-sensors-19-01313],[@B16-sensors-19-01313],[@B17-sensors-19-01313],[@B18-sensors-19-01313],[@B21-sensors-19-01313]\], authors worked on reliability of Data Packets (DP) from the source node to the destination node. Moreover, for efficient routing, packet size is kept small. Additionally, authors in \[[@B10-sensors-19-01313],[@B17-sensors-19-01313]\] worked on packet size management for reliable and efficient data delivery. The small packet size during data transmission results in fewer collisions during transmission. In addition, mobility management is also an important parameter while designing a routing protocol. This important parameter is focused on by the authors in \[[@B8-sensors-19-01313],[@B11-sensors-19-01313],[@B17-sensors-19-01313],[@B19-sensors-19-01313],[@B20-sensors-19-01313],[@B21-sensors-19-01313]\], respectively. Considering these important parameters, authors in \[[@B10-sensors-19-01313],[@B11-sensors-19-01313],[@B16-sensors-19-01313],[@B17-sensors-19-01313],[@B21-sensors-19-01313]\] performed single hop routing. Meanwhile, multi-hop routing is also considered in \[[@B8-sensors-19-01313],[@B9-sensors-19-01313],[@B16-sensors-19-01313],[@B17-sensors-19-01313],[@B18-sensors-19-01313],[@B19-sensors-19-01313],[@B20-sensors-19-01313],[@B21-sensors-19-01313]\].

The energy effective routing is enhanced by the authors in \[[@B8-sensors-19-01313],[@B9-sensors-19-01313],[@B10-sensors-19-01313],[@B11-sensors-19-01313],[@B12-sensors-19-01313],[@B13-sensors-19-01313],[@B14-sensors-19-01313],[@B15-sensors-19-01313],[@B16-sensors-19-01313],[@B17-sensors-19-01313],[@B18-sensors-19-01313],[@B19-sensors-19-01313],[@B20-sensors-19-01313]\].


on additional EC problem in UWSN, which degrades the network performance. Extra resource allocation and network security are the key challenges in \[[@B16-sensors-19-01313],[@B17-sensors-19-01313]\], respectively. However, the network is facing a high E2E delay. Additionally, both protocols are not performing effectively in the sparse network. Complexity and data loss are the serious challenges in \[[@B18-sensors-19-01313],[@B19-sensors-19-01313]\]. Moreover, extra memory is needed to compute extra calculations in \[[@B18-sensors-19-01313],[@B19-sensors-19-01313]\]. Overhead in routing and security issues with the complex networks are the important challenges in \[[@B20-sensors-19-01313],[@B21-sensors-19-01313]\]. In the end, packet E2E delay and network complexity is increased in the aforementioned papers.

1.2. Topology Based Routing {#sec1dot2-sensors-19-01313}
---------------------------

The topology based protocols are elaborated in \[[@B9-sensors-19-01313],[@B12-sensors-19-01313],[@B13-sensors-19-01313]\] with their achievements, challenges and limitations. The protocol implemented in \[[@B9-sensors-19-01313]\] is multi-hop. Moreover, the protocol proposed in \[[@B13-sensors-19-01313]\] is singleproblem.

3.3. LETR {#sec3dot3-sensors-19-01313}
---------

A homogeneous model is proposed in LETR as shown in [Figure 6](#sensors-19-01313-f006){ref-type="fig"}. It is clear from the figure that sensor nodes are randomly deployed in the network \[[@B14-sensors-19-01313]\] and multiple sinks (housed with both acoustic and radio modems) are placed at the sea surface. These nodes are provided with GPS facility to determine their location. Initially, all sensor nodes broadcast the beacon message, while the sink nodes only once. The size of this beacon message is kept small (to minimize the EC). With the passage of time, the location of the nodes get updated and become ineffective. Therefore, sensor nodes broadcast periodic beacon (to be up to date). LETR prioritizes adaptive transmission range adjustment over DA to save the extra EC. It performs geographic and opportunistic


acoustic signal and $Dis$ is the distance among $n - 1$ and *n*th nodes. Whereas, SNR follows the additive white gaussian noise channel.

**Transmission and Receiving Energy Calculations in BF-SPR-Three**

The EC of the sensor nodes during the packet transmission and reception is calculated using Equations ([9](#FD9-sensors-19-01313){ref-type="disp-formula"}) and ([10](#FD10-sensors-19-01313){ref-type="disp-formula"}).

E

t

r

a

n

s

=

T

p

×

P

L

D

R

×

D

i

s

,

E

r

e

c

=

R

p

×

P

L

D

R

×

D

i

s

.

Here, the EC of the sensor nodes during the packet transmission is denoted as $E_{trans}$. $E_{rec}$ is used to represent the EC of the sensor nodes during the packet reception. Whereas, $T_{p}$ and $R_{p}$ denotes transmission and reception power of the sensor node, respectively. Packet size is represented as $PS$ and $DR$ is used to represent the data rate of the acoustic channel. The total residual energy of the nodes in the underwater environment after forwarding all the DP is denoted as(BF-SPR-Three) is discussed. The detail is given below.

Algorithm 2

Algorithm of BF-SPR-Three for data forwarding

Firstly, the input parameters for the routing protocols are initialized. Then, the sensor, sink and relay nodes are deployed in the network with different surface gateways. Afterwards, a beacon message is broadcasted, which helps the neighbor nodes to update their routing table. Moreover, the protocol checks the 3-hop neighbor's availability to avoid the void hole problem. In the end, transmission begins by selecting the next forwarder node given by the 'BF' algorithm (by providing the fastest and shortest path, to route the DP from the source node to the destined sink). Moreover, if the next forwarder is the simple sensor node, it will unicast the DP; otherwise, it will multicast the DP. In the end,


of nodes. In the end, comparative analysis is performed with benchmark routing protocols. It is evident that the EC of the proposed protocols is minimized (25--56% of the state-of-the-art routing protocols) in a dense network. And, outperformed the benchmark routing protocols in counterparts.

Future Work
-----------

In the future, the proposed protocols will be exploited further to implement some artificial intelligence techniques to avoid the void hole in IoT-UWSN. Implementing these techniques on the testbed will be our new research direction for getting more precision in data reliability. In addition, the proposed routing protocols do not reflect quickly during the dynamic topological changes in the IoT-UWSN. Therefore, the handling of these issues will also be part of our future directions. Furthermore, the density of the simulation is too high in ourmethods, there are used aqueous inks, oily inks or solid (melting type) inks.
Colorants to be used in these inks for the inkjet recording method are required to have a high solubility in a solvent such as water, realize high-density recording, provide a good hue, have excellent fastness against light, heat, active gases in the environment (e.g., oxidative gases such as NOx and ozone, and SOx), water and chemicals, show an enough good fixability for an image-receiving material not to be blurred, have an excellent keeping quality as an ink, have no toxicity, have a high purity and be available at a low price.
In particular, it has eagerly been required for dyes to have excellent fastness against light, humidity, heat and, particularly in the case of printing on an


One of the premiere design firms is the Aaron Sims Company and they worked with Weta Digital to create the CGI apes for Dawn of the Planet of the Apes. Gino Acevedo, Creative Art Director at New Zealand effects house Weta
Digital said he had to give a lot of credit to "a very good friend, a
very talented artist Aaron Sims." Aaron's team helped to bring the digital
apes to life and he told Under the Radar, "There’s still a lot of heartache because digital is sadly putting a lot
of the practical stuff away, but at the same time there’s still a lot of
the physical stuff that we still need to do. Aaron and his company
actually sculpted some busts of Caesar, so we had those as practical
things to look atneed to be used up first, so that we don’t waste food or money, and then start planning my meals around that. For instance, I had a clove of garlic and some onion that was going to go bad soon if I didn’t use it, so tonight’s meal was my CrockPot Chili. I write down whatever meals sound good or whatever our favorites are, that contain the ingredients we have on hand. On occasion I have scoured Pinterest or Googled recipes made with ingredients I need to use up.

Any new ingredients we need go on a list that I text to Matt that week, so he can swing by the store on the way home from work. Once a month I stock up on our food staples online


rivals, including Hezbollah. Since the election, Hariri has in vain tried to set up a cabinet. It has transpired that Hezbollah will not only be a major partner in the cabinet, it could also hold the power to block any decision it doesn't like.

According to Lebanon's constitution, any cardinal decision like approving the budget or going to war requires the support of two thirds of the 30-strong cabinet members. So if one movement or coalition of movements has a third plus one minister it can foil any decision – which is exactly what Hezbollah wants. It is also acting to appoint one more minister from among the independent Sunni elected officials who support the organization, which would expand its power to four ministers. Together with the ministers thatDonald Trump report not only on military cooperation with the Lebanese army but about implementing UN Resolution 1701, which was passed in 2006 as part of the end of the Second Lebanon War. Under the resolution, the Lebanese army must be deployed in South Lebanon and prevent Hezbollah from gaining control south of the Litani River. It must also help UN forces enforce the resolution, which includes disarming Hezbollah.

The Lebanese army was the first to fight with American special forces against the Islamic State's bases on the Lebanon-Syria border, but it also cooperated with Hezbollah for the same goal. As for disarming Hezbollah, nobody in Lebanon would even consider discussing the issue.

Israel has complained for over a decade that Hezbollah does not implement Resolution 1701 as it continues


signal) between the actual signal and predicted signal derived from the output of the quantizer, and then to transmit this encoded data efficiently by means of Huffman coding or by transmitting the number of zero MSBs (most significant bits) once only for a block of words or similar techniques of reducing the wordlengths of the individual samples of the encoded waveform. In such prior art systems, lossless decoding is done by using Huffman or other appropriate decoding to restore the wordlength of the encoded signal, and then to pass the encoded data into an identical predictor filter to that used in encoding, to add the result to the encoded signal, and then to restore the original integer valued signal by means of a second rounding quantization operation. Therounding operations may be omitted if the prediction filters have only integer coefficients.
However, in many applications, prior art methods of lossless encoding and decoding of waveform data have considerable practical problems. This is particularly the case with high quality PCM audio data, especially when transmitted through media with limitations on the peak data rate at which data can be transferred, such as compact disc players or digital tape recorders.
By high quality audio we mean signals which in PCM form will typically require 16 or more bits, perhaps as many as 20 or 24 bits, for accurate representation of the digital words, and sampling rates of 44.1 kHz or higher. Lossless compression of audio data is especially useful when in addition the sampling rate is a high figure such


located at the C4/C5 vertebral level. Axial T2-weighted MRI showed a flattened spinal cord and intramedullary signal hyperintensity on the right side (Fig. [1b](#F1){ref-type="fig"}). Sagittal T2-weighted cervical MRI in the flexion position showed expansion of the posterior extradural space and forward displacement of the spinal cord at the C3--C6 vertebral level (Fig. [1c](#F1){ref-type="fig"}). Axial T2-weighted MRI showed hyperintensity of the posterior extradural space at the C4--C5 vertebral levels. Gadolinium-enhanced T1-weighted MRI with flexion position showed homogeneous enhancement of the posterior extradural space at the C3-C6 vertebral levels (Fig. [1d](#F1){ref-type="fig"}). Cervical myelography in a flexed position showed cervical cord atrophy at the C4--C5 vertebral levels with a narrowed dural canal and forward displacement of the cervical cord at the C4--C6 vertebral levels (Fig. [2](#F2){ref-type="fig"}).

We provided guidance in avoiding neckthe spinal cord at the C3--C6 vertebral level. **d** Gadolinium-enhanced T1-weighted MRI with flexion position showed homogeneous enhancement of the posterior extradural space at the C3--C6 vertebral levels.](crn-0011-0106-g01){#F1}

![**a** Sagittal cervical myelography in flexion position shows marked atrophy of the spinal cord at the C4--C5 vertebral level. **b**, **c** Axial cervical myelography in neutral and flexion positions shows flattened spinal cord and forward displacement of the spinal cord at the C4/C5 vertebral level.](crn-0011-0106-g02){#F2}

######

Previously reported cases of proximal upper extremity cervical flexion myelopathy

  First author \[Ref.\], year   Sex    Age at on-set, years   Age at diagnosis, years   Muscle weakness


Electronic structure and reactivity of low-spin Fe(III)-hydroperoxo complexes: comparison to activated bleomycin.
The spectroscopic properties, electronic structure, and reactivity of the low-spin Fe(III)-hydroperoxo complex [Fe(N4Py)(OOH)](2+) (1, N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) are investigated in comparison to those of activated bleomycin (ABLM). Complex 1 is characterized by Raman features at 632 (Fe-O stretch) and 790 cm(-1) (O-O stretch), corresponding to a strong Fe-O bond (force constant 3.62 mdyn/A) and a weak O-O bond (3.05 mdyn/A). The UV-vis spectrum of 1 shows a broad absorption band around 550 nm that is assigned to a charge-transfer transition from the hydroperoxo to a t(2g) d orbital of Fe(III) using resonance Raman and MCD spectroscopies and density functional (DFT) calculations. Compared to low-spin [Fe(TPA)(OH(x))(OO(t)Bu)](x+)(TPA = tris(2-pyridylmethyl)amine, x = 1 or 2), an overall similar Fe-OOR bondingas an insurance scheme for its registered members, Indian passport and council services , free medical and legal consultation camp once in every month, as well as cultural and religious programs. Kerala Muslim Cultural Centre Dubai opened a help desk to collect the documents of Indian expats wishing to seek amnesty recently.

KMCC Qatar
KMCC Qatar is one of the most highest gross charity doing every year (showing as per different levels Data collection up to 2016).

References

External links

Category:Muslim communities of Kerala
Category:Indian Union Muslim League


after its opening.

The main construction works were finished in October 2014. Since January 2015 the church has been active.

There also was a scandal about handing the building of the former church, which is now occupied by the puppet theatre, to the Russian Orthodox Church. The Church representatives stated that the theatre would stay in the building until another appropriate place for it was found.

References

Category:Churches in Rostov Oblast
Category:Greek Orthodox churches
Category:Greek diaspora in Russia
Category:Churches completed in 1909
Category:Churches completed in 2014case of analog
      watchdog or overrun events.

  (#) Single and continuous conversion modes.

  (#) Scan or discontinuous mode conversion of channel 0 to channel 18.

  (#) Configurable scan direction (Upward from channel 0 to 18 or Backward from
      channel 18 to channel 0)

  (#) Data alignment with in-built data coherency.

  (#) Channel-wise programmable sampling time.

  (#) External trigger option with configurable polarity.

  (#) DMA request generation during regular channel conversion.

  (#) ADC supply requirements: 2.4 V to 3.6 V at full speed and down to 1.8 V at
      slower speed.

  (#)


        */
    HAL_ADC_ConvCpltCallback(hadc);

    /* Clear regular channels conversion flag */
    if (hadc->Init.LowPowerAutoWait != ENABLE)
    {
      __HAL_ADC_CLEAR_FLAG(hadc, (ADC_FLAG_EOC | ADC_FLAG_EOS) );
    }
  }

  /* Check Analog watchdog flags */
  if( (__HAL_ADC_GET_FLAG(hadc, ADC_FLAG_AWD) && __HAL_ADC_GET_IT_SOURCE(hadc, ADC_IT_AWD)))
  {
    /* Change ADC state */
    hadc->State = HAL_ADC_STATE_AWD;

    /* Level out of window callback */
    HAL_ADC_LevelOutOfWindowCallback(hadc);

    /* Clear ADC Analog watchdog flag */
    __HAL_ADC_CLEAR_FLAG(hadc, ADC_FLAG_AWD);
  }

  /* Check Overrun flag */
  if(__HAL_ADC_GET_FLAG(hadc, ADC_FLAG_OVR) && __HAL_ADC_GET_IT_SOURCE(hadc, ADC_IT_OVR))
  {
    /* Change ADC state to overrun state */
    hadc->State = HAL_ADC_STATE_ERROR;

    /* Set ADC error code to overrun */
    hadc->ErrorCode |= HAL_ADC_ERROR_OVR;

    /* Clear the Overrun flag */
    __HAL_ADC_CLEAR_FLAG(hadc,ADC_FLAG_OVR);

    /* Error callback */
    HAL_ADC_ErrorCallback(hadc);
  }
}

/**
  * @brief  Enables ADC DMA request after last transfer (Single-ADC mode) and enables ADC peripheral
  * @param  hadc: pointer to a ADC_HandleTypeDef structure that contains
  *


enabled */
    if (tmpHALStatus != HAL_ERROR)
    {
      /* Enable ADC DMA mode */
      hadc->Instance->CFGR1 |= ADC_CFGR1_DMAEN;

      /* Set the DMA transfer complete callback */
      hadc->DMA_Handle->XferCpltCallback = ADC_DMAConvCplt;

      /* Set the DMA half transfer complete callback */
      hadc->DMA_Handle->XferHalfCpltCallback = ADC_DMAHalfConvCplt;

      /* Set the DMA error callback */
      hadc->DMA_Handle->XferErrorCallback = ADC_DMAError;

      /* Manage ADC and DMA start: ADC overruninternal measurement channels: Vbat/VrefInt/TempSensor  */
  if (ADC_IS_CONVERSION_ONGOING(hadc) != RESET)
  {
    /* Update ADC state machine to error */
    hadc->State = HAL_ADC_STATE_ERROR;
    /* Process unlocked */
    __HAL_UNLOCK(hadc);
    return HAL_ERROR;
  }

  /* Enable selected channels */
  hadc->Instance->CHSELR |= (uint32_t)(sConfig->Channel & ADC_CHANNEL_MASK);

  /* Management of internal measurement channels: Vlcd/VrefInt/TempSensor     */
  /* internal measurement paths enable: If internal channel selected, enable  */
  /* dedicated internal buffers and path.


  */
  /* conversion on going :                                                    */
  if (ADC_IS_CONVERSION_ONGOING(hadc) != RESET)
  {
    /* Update ADC state machine to error */
    hadc->State = HAL_ADC_STATE_ERROR;
    /* Process unlocked */
    return HAL_ERROR;
  }

  /* Verification: if ADC is not already stopped, bypass this function */
  if (HAL_IS_BIT_SET(hadc->Instance->CR, ADC_CR_ADSTART))
  {
  <Pressed scalemode="STRETCH_ASPECT">skin:../Deere/icon/ic_clear_48px.svg</Pressed>
              <Unpressed scalemode="STRETCH_ASPECT">skin:../Deere/icon/ic_clear_48px.svg</Unpressed>
            </State>
            <State>
              <Number>1</Number>
              <Text><Variable name="state_1_text"/></Text>
              <Pressed scalemode="STRETCH_ASPECT">skin:../Deere/icon/ic_clear_48px.svg</Pressed>
              <Unpressed scalemode="STRETCH_ASPECT">skin:../Deere/icon/ic_clear_48px.svg</Unpressed>
            </State>
            <Connection>


     <SetVariable name="text">8 Hotcues</SetVariable>
            <SetVariable name="skinsetting">[Skin],show_8_hotcues</SetVariable>
          </Template>

          <Template src="skin:../Deere/skinsettings_button.xml">
            <SetVariable name="TooltipId">show_intro_outro_cues</SetVariable>
            <SetVariable name="text">Intro & Outro Cues</SetVariable>
            <SetVariable name="skinsetting">[Skin],show_intro_outro_cues</SetVariable>
          </Template>

          <Template src="skin:../Deere/skinsettings_button.xml">
            <SetVariable name="TooltipId">show_vinylcontrol</SetVariable>
          were either farm
laborers or did some form of back breaking manual labour. The literacy rate
was horrible and so forth. I doubt very much these farm workers could not
transition into some from of service jobs with very little training. Or some
lateral move into other manual labor positions in other parts of the economy.

I hired someone from Mexico on a visa into a 6 figure a year job who's father
was literally a farm laborer. He was quite capable to do his job. Expecting
nothing from people is a self fulfilling prophecy.

~~~
mc32
While it's true immigrants in the 19 and early 20th centuries were uneducated,
they had a generation or two available to catch up. In today's day and age,
they have a few years to adjust to this new reality.

It's true that a good


     }
    }

Now, if I override SIZE property in my class which inherits from the base class, does MAX then calculate SIZE from base class or from inherited class ( or should it be just SIZE without this ) ?
EDIT: Forgot to mention, Vector3b is just basicly Vector3 but it uses bytes instead of floats.

A:

A virtual property or method by definition dispatches the method based on the runtime type of the receiver. In your example, if the runtime type is the derived class, then the derived property is called.

A:

MAX will use the derived class SIZE if the runtime type of this reference is the derived type. It's called dynamic dispatch of virtual methods and properties, based on the runtime type ofin January, the canine sleuth has sniffed thousands of pounds of cocaine out of the dark, helping her handlers find the drug hidden in boxes full of gym shoes and wooden necklaces.

A few months ago, the tenacious hound also detected 77 kilos of cocaine placed deep inside an industrial machine.

The work is risky: Colombia’s national police estimates they’ve lost at least 1,800 officers over the past two decades and a number of dogs to the war on drugs.

Some officers were killed by hitmen acting on the orders of drug traffickers, while others died in attacks like bombings on police stations.

Several dogs have been killed while helping officers eradicate coca crops.

Sombra’s victories have turned her into somewhat of a media darling, and as she struts around Bogota’s airport with


${\mathrm{F}}_4(2)$ provided the following conditions hold.

1.  $Q=F^*(X)$ is extraspecial of order $3^5$ and $Z(F^*(X)) =Z(X)$; and

2.  $X/Q$ contains a normal subgroup isomorphic to $ {\mathrm{Q}}_8\times {\mathrm{Q}}_8$.

Our main theorem is as follows.

\[MT\] Suppose that $G$ is a group, $Z \le G$ has order $3$. If $C_G(Z)$ is similar to a $3$-centralizer in a group of type $\PSU_6(2)$ or ${\mathrm{F}}_4(2)$ and $Z$ is not weakly closed in $F^*(C_G(Z))$, then $G \cong {\mathrm{F}}_4(2)$ or ${\mathrm{Aut}}({\mathrm{F}}_4(2))$.

Combining Theorem \[MT\] and the main theorem from [@PS1] we obtain the following statement.

\[combT\] Suppose that $G$ is a group, $Z \le G$ has order $3$. If $C_G(Z)$ is similar to a $3$-centralizer in a group of type $\PSU_6(2)$ or ${\mathrm{F}}_4(2)$ and $Z$ is not weakly closed in a Sylow $3$-subgroup of $C_G(Z)$ with respect towe follow the now standard Atlas [@Atlas] notation for group extensions. Thus $X\udot Y$ denotes a non-split extension of $X$ by $Y$, $X{:}Y$ is a split extension of $X$ by $Y$ and we reserve the notation $X.Y$ to denote an extension of undesignated type (so it is either unknown, or we don’t care). Our notation follows that in [@AschbacherFG], [@Gorenstein] and [@GLS2]. We use the definition of signalizers as given in [@GLS2 Definition 23.1]. For odd primes $p$, the extraspecial groups of exponent $p$ and order $p^{2n+1}$ are denoted by $p^{1+2n}_+$. The extraspecial $2$-groups of order $2^{2n+1}$ are denoted by $2^{1+2n}_+$ if the maximal elementary abelian subgroups have order $2^{1+n}$ and otherwise we write $2^{1+2n}_-$. We expect our notation for specific groups is self-explanatory. For a subset $X$


the structure of $M$.

\[U6F4\] We have that $M/Q$ normalizes $R^*/Q$ and is isomorphic to a subgroup of the subgroup $\mathbf M$ of $\GSp_4(3)$ which preserves a decomposition of the natural $4$-dimensional symplectic space over ${\mathrm{GF}}(3)$ into a perpendicular sum of two non-degenerate $2$-spaces. Furthermore, $R/Q$ maps to $O_2(\mathbf M)$.

See [@PS1 Lemma 3.1].

We next introduce a substantial amount of notation. We will use this for the remainder of the paper. We note now that the subgroups $Q_1$ and $Q_2$ defined below will be shown to have order $3^3$ in Lemma \[Qaction\].

\[nota\]

1.  Define $R_1$ and $R_2$ to be the two subgroups of $R$ isomorphic to ${\mathrm{Q}}_8$ which map to normal subgroups of $C_{\mathbf M}(Z(R)Q/Q)$.

2.  For $i=1, 2$, let $r_i \in Z(R_i)^\#$ and $K_i = C_G(r_i)$.

3.  For $i=1,2$, define[W,Q]=A$ and $C_J(S)= Z$.

Now $\langle Z^{L_*}\rangle \ge \langle Z^H\rangle \langle Z^{H_1}\rangle = VV_1= A$ and, as $A \not \le Q\cap
Q^g$, $A$ is not normalized by $H$. Hence $\langle Z^{L_*}\rangle=J$ and, in particular, $L_*$ and, consequently, $L$ acts irreducibly on $J$. Thus there are members of $\mathcal S(J)$ in $J\setminus A$. By Lemma \[3classes\] there are exactly $14$ elements of $\mathcal S(J)$ in $A$ and in $J\setminus A$ there are a multiple of 18 such elements. Thence $|\mathcal S(J)| = 14+ n\cdot 18$ for some integer $n\ge 1$. Since $|J|= 3^4$, using the fact that $|\mathcal S(J)| $ divides $|{\mathrm{GL}}_4(3)|$ we infer that $|\mathcal S(J)|= 32$.

Using Lemma \[GO4\] with $\langle a \rangle = Q_1J/J$ and $\langle b \rangle = Q_2J/J$, yields that $S$ preserves a quadratic form with any element of


O_2(C_{K_2}(A_1)) = R_2$.

\[sigmai\] We have $\Sigma_i$ is extraspecial of order $2^9$ and plus type, $Z(\Sigma_i)= \langle r_i\rangle$ and $F_i/\langle r_i\rangle$ acts faithfully on $\Sigma_i$.

The structure of $\Sigma_i$ follows from Lemma \[Sigmapieces\] (iii) as the generating subgroups commute pairwise. To see the last part is suffices to show that $I_i$ acts faithfully on $\Sigma_i$ as every normal subgroup of $F_i$ which strictly contains $\langle r_i\rangle$ contains $I_i$. Using Lemma \[Sigmapieces\] (iv) we see that $C_{I_i}(\Sigma_i) = \bigcap_ {j=1}^4I_i^j= 1$.

At this stage we have constructed the extraspecial group of order $2^9$ on which $F_i$ acts.

\[celts\] The following hold:

1.  $C_{\Sigma_1}(Z)=R_1$, $C_{\Sigma_1}(I_1^j \cap I_1^k) =\Sigma_1^j\Sigma_1^k$ and, if $\langle x \rangle \in \mathcal P(I_1)$, then $C_{\Sigma_1}(x) =\langle r_1\rangle$.

2.  $C_{\Sigma_2}(Z)=R_2$, $C_{\Sigma_2}(I_2^j \cap I_2^k) =\Sigma_2^j\Sigma_2^k$ and, if $\langle x \rangle \in \mathcal M(I_2)$, then $C_{\Sigma_2}(x)on the track of ${\mathrm{F}}_4(2)$ and ${\mathrm{Aut}}({\mathrm{F}}_4(2))$.

\[ItsSp62\] We have $C_G(\rho_1) \cong C_G(\rho_2) \cong 3 \times {\mathrm{Sp}}_6(2)$.

Suppose that the lemma is false. Then by Lemmas \[eitheror\] and \[thesame\] $$C_G(\rho_1) \cong C_G(\rho_2) \cong 3 \times {\mathrm{Aut}}({\mathrm{SU}}_4(2)).$$ We claim that, for $i=1,2$, $\Sigma_i$ is self-centralizing in $K_i$. Let $W_i= C_G(\Sigma_i)$. Then $W_i \le K_i$ and, as $C_S(r_i) \in {\mathrm{Syl}}_3(K_i)$ by Lemma \[CSr\] and since this group acts faithfully on $\Sigma_i$ by Lemma \[sigmai\], we have that $W_i$ is a $3'$-group which is normalized by $I_i^1$. By Lemma \[uniqueAisig1\], $\Sigma_i$ is the unique maximal signalizer for $I_i^1$ and hence $\Sigma_i \ge W_i$.

Since $\Sigma_i$ is the unique maximal signalizer for $I_i^1$ in $K_i$ it is also the unique maximal signalizer of $Q_{3-i}\ge I_i^1$ and $I_i\ge I_i^1$ in $K_i$. It follows that $N_G(\Sigma_i) \ge \langle F_i, C_M(r_i)\rangle $


\cap I_2|= 3^2$, there is $w \in C_{I_1\cap I_2}(\Sigma_1\cap
\Sigma_2)^\#$. Now $(\Sigma_1 \cap \Sigma_2)\langle r_1 \rangle$ is elementary abelian. Since for $a \in \mathcal
S(I_1\cap I_2)$ have $C_{\Sigma_1}(a) \cong {\mathrm{Q}}_8$ and $a \in \mathcal P(I_1 \cap I_2)$ have $C_{\Sigma_1}(a)=
\langle r_1 \rangle$, we must have $\langle w \rangle \in \mathcal M(I_1\cap I_2)$. But then $\Sigma_1\cap \Sigma_2
\le C_{\Sigma_2}(w)=1$ by Lemma \[celts\]. This means that $\Sigma_1 \cap \Sigma_2=1$ which then forces $[C_{\Sigma_1}(r_2),
C_{\Sigma_2}(r_1)]=1 $ and Lemma \[sp62facts\] (iv) provides a contradiction.

Some subgroups in the centralizer of the involutions $r_1$ and $r_2$
====================================================================

In this section, we finally construct $O_2(K_i)$ where $K_i= C_G(r_i)$. Recall from Definition \[F4cent\], we expect $O_2(K_i) $ to be a product of an elementary abelian group of order $2^7$ by an extraspecial group of order $2^9$. We have already located the extraspecial group $\Sigma_i$. In this(I_i^1)^\#\rangle.$$ If $\langle x \rangle =Z\in \mathcal S (I_i^1)$, then $$O_{3'}(C_{K_i}(Z))=R_i =\Sigma_i^1 \le \Sigma_i\le
\Gamma_i$$ is the unique maximal $I_i^1$ signalizer in $C_{K_i}(Z)$. All the other subgroups of order $3$ in $I_i^1$ are conjugate to $\langle \rho_{3-i}\rangle$ by an element of $Q_{3-i} \le F_i$. Hence we only need to consider $I_i^1$ signalizers in $C_{K_i}(\rho_{3-i})$. By Lemma \[ItsSp62\], $C_{G}(\rho_{3-i}) = C_G(I_i^1\cap I_i^2) \cong 3 \times {\mathrm{Sp}}_6(2)$ and we know from Lemma \[cri\] that $$C_{K_i}(\rho_{3-i}) \approx 3 \times 2^{1+2+4}.({\mathrm{Sym}}(3) \times {\mathrm{Sym}}(3)).$$ Set $D= C_{K_i}(\rho_{3-i})$. Then $$O_2(D)=  \Sigma_i^1\Sigma_i^2\Theta_i^{1,2} \le \Gamma_i$$ and, Lemma \[sp62line\](ii), implies $ZO_2(D)/O_2(D)$ is diagonal in $D/O_2(D)$. Since $C_W(\rho_{3-i})$ is normalized by $Z$ we infer that $C_W(\rho_{3-i}) \le \Gamma_i$ as claimed.

\[fusionr\_i\] For $i=1,2$, there is a $G$-conjugate of $r_i$ in $\Gamma_i\setminus \Upsilon_i$.

This fusion can already be seen in $$C_{K_i}(\rho_{3-i})\approx 3 \times


$s \in T \setminus \Gamma_1$. Then the following hold:

1.  $C_{\Gamma_1/\Upsilon_1}(s) = C_{\Gamma_1}(s)\Upsilon_1/\Upsilon_1$; and

2.  $C_{H_1}(s)$ is a $3^\prime$-group.

By Lemma \[snormsigma\] we may assume that $s$ normalizes both $I_1\Gamma_1$ and $\Sigma_1$. Let $w \Upsilon_1 \in C_{\Gamma_1/\Upsilon_1}(s)$ and write $w= w_*u$ where $w_* \in \Sigma_1$ and $u \in \Upsilon_1$. Then $$[w,s]= [w_*u,s] = [w_*,s][u,s] \in \Upsilon_1.$$ As $s$ normalizes $\Sigma_1$, this means that $[w_*,s]\in \Sigma_1\cap \Upsilon_1 = \langle r_1\rangle$. Since $x$ is not $K_1$-conjugate to $sr_1$, we deduce that $w_*$ is centralized by $s$ and this proves (i).

Suppose that $W \in {\mathrm{Syl}}_3(C_{H_1}(s))$ and let $U \in {\mathrm{Syl}}_3(C_{H_1}(x))$. Then, as $ \Upsilon_1/\langle
r_1\rangle$ is the natural ${\mathrm{Sp}}_6(2)$-module, $U$ has order $3^2$ by Lemma \[sp62natural\]. Since by Lemma \[Strong3\] $H_1$ is strongly $3$-embedded in $K_1$ we know that $U\in  {\mathrm{Syl}}_3(C_{K_1}(x))$ and so $U^g \inproperties *in vivo* for subacute period to validate its use as a medicinal substance available worldwide.

Materials and Methods {#sec1-2}
=====================

Chemicals and reagents {#sec2-1}
----------------------

Cyclophosphamide, Colcemid, bromodeoxyuridine (BrdU) tablets Giemsa dye, standard silymarin flavonolignans (S0292), and reagents (methanol and acetic acid) were purchased from Sigma-Aldrich Co, USA.

Milk thistle plant materials {#sec2-2}
----------------------------

Seeds of milk thistle were collected between July and August, from the flower heads of the plant, grown on the rocky slopes of the middle of Sarawat mountains range known as Sarat Albaha region that rises up to 2800 meters in South Western Saudi Arabia. The sample was identified by Prof. Naser Abdulla Awad Ali of Pharmacognosy Department, College of Clinical Pharmacy, Albaha University; voucher specimen (A530) is stored in the herbarium of Pharmacognosy laboratory. Dried seed (150 g) were grounded


of positive and negative control.\[[@ref12]\] Animals of the negative control group received equivalent amounts of deionized water. Each animal was injected with 0.1 mL colcemid (20 mg), 21 h after applying the last dose of treatment. Animals were decapitated 24 h after the last dose, except for the analysis of primary spermatocytes (PS), where animals were decapitated 10 days after the last dose.

Harvesting of bone marrow {#sec2-7}
-------------------------

Animals were sacrificed and cervical dislocation technique was applied to remove both animal femurs, extraneous tissues and bone tips were discarded to allow a 26-gauge syringe needle to be inserted to flush out the femoral contents with phosphate buffered saline (pH 7.0). Cell suspension around 8 mL was microfuged at 1000 rpm (5 min), and cell pellet was recovered. The pellet was1](#T1){ref-type="table"} that the mitotic activity obtained after treatments with silymarin in combination with the PC, although was lower than that obtained after treatment with the silymarin alone, it was either equal to or even higher than the negative control, giving further evidence that silymarin counters the effect of cyclophosphamide.

![Photomicrograph illustrating the analysis of metaphase showing aberrations. (a) stickiness "S" and chromosome deletion; (b) chromosome deletion; (c) micronucleated polychromatic erythrocytes micronucleated polychromatic erythrocytes; (d) diakinesis stage showing robertsonian centric fusion after treatment with the positive mutagenic agent cyclophosphamide](IJPharm-50-108-g002){#F2}

######

Effect of silymarin on mitotic activity as indicated by mitotic index of mice bone marrow cells

![](IJPharm-50-108-g003)

The CA results are summarized in [Table 2](#T2){ref-type="table"}. It was observed that there is no increase in CA following all silymarin treatments. However, treatment with the


social relationship online experts singles women seeks men for sex. Divorce rate is different than an individual chance of divorce my sister and i have both been married once without a divorce my brother has been divorced twice.

Brookesmith dating: browse brookesmith, tx singles & personals lone star state of texas become a member and create a free personals ad you're here to meet people and find a profile in brookesmith, texas matchcom helps you do that. Zillow helps you find the newest brookesmith real estate listings by analyzing information on thousands of single family homes for sale in brookesmith, texas and across the united states, we calculate home values (zestimates) and the zillow home value price index for brookesmith proper, its neighborhoods and surrounding areas. Divorce leaves singleIntroduction
============

Premature ejaculation (PE) is a common type of sexual dysfunction that affects approximately 20--30% of all men ranging from 18 to 55 years of age ([@b1-etm-0-0-3595],[@b2-etm-0-0-3595]). PE is detrimental to self-confidence and the relationship with a partner ([@b3-etm-0-0-3595],[@b4-etm-0-0-3595]). Lifelong PE is that which occurs from the first sexual experience and remains a problem throughout life. Ejaculation occurs too rapidly, either prior to vaginal penetration or \<2 min afterwards ([@b3-etm-0-0-3595],[@b4-etm-0-0-3595]). Currently, pharmacotherapy is the primary treatment for lifelong PE; however, PE is an off-label indication for all medical treatments (with the exception of dapoxetine in some countries) ([@b3-etm-0-0-3595]). Chronic selective serotonin reuptake inhibitors (SSRIs) and on-demand topical anaesthetic agents are the only drugs to have consistently shown efficacy in PE ([@b3-etm-0-0-3595]). Although there is some evidence of good efficacy


therapy with EndEP^®^ (one tablet/day) for 90 days. All patients were contacted by telephone on day 30 of the therapy to ensure the dosing and timing of treatment was correct. Each subject was scheduled for follow-up examination at 90 days from starting therapy, with a urological visit, and IPSS, IIEF-15, PEDT and SF-36 questionnaires. Moreover, all PROs were collected. No placebo arm was included. The possible biases caused by the lack of placebo arm were considered in the analysis of the results. [Figure 1](#f1-etm-0-0-3595){ref-type="fig"} shows a flow-chart of the study protocol. Clinical failure was defined as the persistence of symptoms following the treatment, or the suspension of therapy for significant reported adverse effects. In addition, spontaneously reported adverse events, or those noted by the investigator, were recorded duringwere calculated by subtracting the baseline value from the end-of-trial value. Analysis of variance was used for comparing means, and the Bonferroni adjustment test was used at the second stage of the analysis of variance. The sample size was calculated prospectively under the following conditions: Difference between the groups=10% (reduction in PEDT questionnaire score), α error level=0.05 two-sided, statistical power = 80% and anticipated effect size (Cohen\'s d=0.5). The calculation yielded 72 individuals. Assuming a dropout rate of approximately 20%, 86 patients should be enrolled into the study. The main outcome measure was the difference from baseline in PEDT questionnaire, mean IELT and PROs at the end of the follow-up period. P\<0.05 was considered to indicate a statistically significant difference. SPSS software, version 11.0 (SPSS Inc., Chicago, IL,


in prostate health and in ejaculatory reflex health ([@b28-etm-0-0-3595]). Finally, biotin contributes to normal psychological and sexual function and this effect should be useful in the management of patients with PE ([@b29-etm-0-0-3595]).

The present study shows some strengths of the treatment. Firstly, the use of phytotherapy for the treatment of PE was well accepted by the patients (95.7% compliance to the protocol). Moreover, the very low prevalence of adverse events contributed to the high compliance with the protocol. Furthermore, the exclusion of all patients with concomitant therapy for PE is a very important aspect to highlight, as it enabled the present study to demonstrate the effects of EndEP^®^ alone. However, even if the results are encouraging, this study has several limitations. Firstly, it lacks a placebo arm; however, thisterminated by Het2, a N-linked heterocyclic group (selected from piperidinyl and morpholinyl) or phenyl (which latter group is optionally substituted by one or more substituents selected from halo, xe2x80x94CN, xe2x80x94CF3, xe2x80x94OCF3, C1-4 alkoxy or C1-4 alkyl (which latter two groups are optionally substituted by C1-4 haloalkyl or C1-4 haloalkoxy));
R4 represents H or C1-4 alkyl;
R3 represents OR5 or N(R6)R7;
R5 represents C3-6 cycloalkyl, xe2x80x94(C1-4 alkylene)-1-piperidinyl, tetrahydrofuranyl, tetrahydropyranyl or C1-6 alkyl, which latter group is optionally substituted and/or terminated by one or two substituents selected from C3-5 cycloalkyl, xe2x80x94OR8, xe2x80x94N(R6)R7, phenyl, furanyl and pyridinyl, and which C1-6 alkyl group is optionally terminated by a C1-4 haloalkyl group;
R6 and R7 independently represent, at each occurrence when used herein, H, C1-4 alkyl (optionally substituted by C3-5 cycloalkyl or C1-4 alkoxy), or R6 and


can also provide pharmaceutically or veterinarily acceptable metal salts, in particular non-toxic alkali and alkaline earth metal salts, with bases. Examples include the sodium, potassium, aluminium, calcium, magnesium, zinc and diethanolamine salts. Pharmaceutically acceptable derivatives also include C1-4 alkyl ammonium salts. For a review on suitable pharmaceutical salts see Berge et al, J. Pharm, Sci., 66, 1-19, 1977.
The pharmaceutically acceptable solvates of the compounds of the invention include the hydrates thereof.
Also included within the scope of the compound and various salts of the invention are polymorphs thereof.
Abbreviations are listed at the end of this specification.
Preferred compounds of the invention include those wherein:
R1 and R2 independently represent optionally substituted phenyl or C1-4 alkyl optionally substituted and/or terminated by Het2 or optionally substituted phenyl;
R3 represents OR5;
R5 represents C1-5 alkyl optionallywhich cGMP PDEs, such as cGMP PDE5, are indicated, and in which inhibition of cGMP PDEs, such as cGMP PDE5, is desirable.
By the term xe2x80x9ctreatmentxe2x80x9d, we include both therapeutic (curative), palliative or prophylactic treatment.
Thus, according to a further aspect of the invention there is provided the use of the compounds of the invention in the manufacture of a medicament for the treatment of a medical condition in which a cGMP PDE (e.g. cGMP PDE5) is indicated. There is further provided the use of the compounds of the invention in the manufacture of a medicament for the treatment of a medical condition in which inhibition of a cGMP PDE (e.g. cGMP PDE5) is desirable or required.
The compounds of the invention are thus expected to be useful for the curative,


dispersing or dissolving dosage formulations (FDDFS) may contain the following ingredients: aspartame, acesulfame potassium, citric acid, croscarmellose sodium, crospovidone, diascorbic acid, ethyl acrylate, ethyl cellulose, gelatin, hydroxypropylmethyl cellulose, magnesium stearate, mannitol, methyl methacrylate, mint flavouring, polyethylene glycol, fumed silica, silicon dioxide, sodium starch glycolate, sodium stearyl fumarate, sorbitol, xylitol.
The compounds of the invention can also be administered parenterally, for example, intracavernosally, intravenously, intra-arterially, intraperitoneally, intrathecally, intraventricularly, intraurethrally intrasternally, intracranially, intramuscularly or subcutaneously, or they may be administered by infusion techniques. For such parenteral administration they are best used in the form of a sterile aqueous solution which may contain other substances, for example, enough salts or glucose to make the solution isotonic with blood. The aqueous solutions should be suitably buffered (preferably to a pH of from 3of the invention to enhance sodium nitroprusside-induced relaxation of pre-contracted rabbit corpus cavernosum tissue strips, as described by S. A. Ballard et al. (Brit. J. Pharmacol., 1996, 118(suppl.), abstract 153P).
In vivo Activity
Compounds were screened in anaesthetised dogs to determine their capacity, after i.v. administration, to enhance the pressure rises in the corpora cavernosa of the penis induced by intracavernosal injection of sodium nitroprusside, using a method based on that described by Trigo-Rocha et al. (Neurourol. and Urodyn., 1994, 13, 71).
Safety Profile
Compounds of the invention may be tested at varying i.v and p.o. doses in animals such as mouse and dog, observing for any untoward effects.


DJ-1 protein was involved in xanthoangelol-induced apoptosis. DJ-1 responded to its oxidative stress status by being oxidized itself. Furthermore, DJ-1 was down-regulated by xanthoangelol, leading to loss of antioxidant function and acceleration of apoptosis. We also show that xanthoangelol has a cytotoxic effect on drug-resistant LA-N-1 and NB-39 cells as well as drug-sensitive IMR-32 and SK-N-SH cells. These findings suggest that xanthoangelol induces apoptosis by increasing reactive oxygen species and targeting DJ-1, and such mechanism may be an effective therapeutic approach for advanced neuroblastoma.grand slam in the first and the
Giants never looked back. Thanks to the run support — which he has not
had a hell of a lot of recently — Barry Zito got his first win since
July 16th.

Cardinals 4, Padres 1: Adam Wainwright shut the Padres down to win his
19th. San Diego falls into second place, a half game behind San Francisco and 2.5 back of the
Braves in the wild card.

Dodgers 7, Rockies 6: The Rockies jumped all over Clayton Kershaw,
grabbing a 6-1 lead after two innings. That’s all they’d get, though, as
L.A. chipped away at the lead, tying it on a Matt Kemp double in the
ninth and winning it on an A.J. Ellis — A.J. Ellis? — yes, A.J. Ellis
RBI single in the 11th. This one ended in a


Yung Lean’s video for “Kyoto” has more than 13 million views on YouTube. Stop and let that sink in for a moment: Many millions of people have been drawn to the music—and the world—created by a Swedish rapper otherwise known as Jonatan Leandoer Håstad, who, until recently, lived at home and wasn’t old enough to legally get into the venues he was invited to play in. Who knows what “AF1’s,” which you can listen to here on Vogue.com, will generate?

In town for Stockholm Fashion Week, I sat down for a conversation with the young star and the de facto leader of the Sad Boys movement.

So what is it that keeps those views coming? It’s more than the music that gets people clicking. The fancy cars and good-looking posse1960s, you certainly would have known about Oleg Cassini, who was responsible for so many of Jackie Kennedy's now-iconic White House ensembles.

Let's give them an encore bow on the runway.

* * *

Paul Poiret (1879-1944)

This Parisian self-proclaimed "King of Fashion," is often credited with emancipating women from corsets, petticoats, and pantaloons; when he opened his maison de couture in 1903, he draped a lucky few instead in luxurious, exotic, robe-like gowns, influenced by the Greek chiton, the Japanese kimono, and the North African and Middle Eastern caftan. He ousted prim fabrics and ushered in brocades and velvets, often in lush jewel tones.

Poiret was considered terribly modern until he wasn't: Chanel's little black dress of the 1920s made his lavish designs look overly-adorned and "old hat." One anecdote describes a


her pocket (or so the story goes), she took a job working for a milliner on Broadway, eventually bought the shop from the owner, and soon became a household name across the country.

* * *

Paco Rabanne (b. 1934)

Carla Bruni models a Rabanne jumpsuit in 1995

Rabanne originally studied to become an architect, but instead became the enfant terrible of the fashion world in the 1960s. Taking a cue from the contemporaneous Pop art movement, he made wild dresses out of chain mail, aluminum panels, and plastic; in 1966 he showed a collection of "12 Experimental and Unwearable Dresses in Contemporary Materials." Anteceding today's concept of so-called disposable fashion by decades, he marketed paper dresses sold in envelopes.

* * *

Madeleine Vionnet (1876 - 1975)

An iconic 1920s and 30s French designer,and will reduce the relative permeability to gas in the invaded region. Near the fracture, the permeability to gas will be reduced to zero.xe2x80x9d In addition, Holditch said: xe2x80x9cIn some cases, the injected fracturing fluid may reduce the formation permeability in the invaded zone.xe2x80x9d Stephen A. Holditch, SPE 7561 (Presented at the 53rd Annual Fall Technical Conference and Exhibition of the Society of Petroleum Engineers of AIME, held in Houston, Tex., Oct. 1-3, 1978). The damage to the formation could be severe, and the practical so what of that is reduced flow of hydrocarbons, low production and poor economics on the well. While the state of the art has advanced substantially since Holditch reported on the problems associated with leak off of fracturing fluid, the problems remain the


same. See, for example, Vernon G. Constien, George W. Hawkins, R. K. Prud""homme and Reinaldo Navarrete, Chapter 8 entitled xe2x80x9cPerformance of Fracturing Materialsxe2x80x9d and the other chapters on fracturing and well stimulation in xe2x80x9cReservoir Stimulationxe2x80x9d published by John Wiley and Sons, Ltd, Third Edition, copyright Schlumberger 2000 (Editors, Michael J. Economides and Kenneth G. Nolte), the disclosure of which is incorporated herein by reference. These authors and others emphasize the importance of xe2x80x9ccleanupxe2x80x9d or xe2x80x9cfracture cleanupxe2x80x9d to optimize production of the hydrocarbon fluids from the well. The term xe2x80x9ccleanupxe2x80x9d or xe2x80x9cfracture cleanupxe2x80x9d refers to the process of removing the fracture fluid (without the proppant) from the fracture after the fracturing process has been completed. Techniques for promoting fracture cleanup often involved reducing the viscosity of the fracture fluidof the calves around the age of 10 years. He became aware of his difficulty in climbing stairs beginning at the age of 20 years. At the age of 28 years, he was admitted to a university hospital and diagnosed with sporadic BMD based on his clinical symptoms, serum creatine kinase elevation, and dystrophic changes in his muscle biopsy specimens. However, immunostaining for the muscular dystrophin protein was not available because the *DMD* gene had not been discovered at that time. A few decades after the first diagnosis of BMD, his attending doctor pointed out the possibility that his illness might not be BMD, but limb-girdle muscular dystrophy (LGMD) because the progression of his clinical symptoms was relatively slower than expected. He was intellectually normal. He could walk


group of muscular dystrophies, exclusive of DMD/BMD, that manifests as weakness and muscle wasting predominantly in the proximal portion of the arms and legs. The genetic background of LGMD is highly heterogeneous. To date, more than 50 responsible genes and loci have been reported. Type 1 LGMD is inherited in an autosomal dominant manner, and type 2 LGMD (LGMD2) is caused by autosomal recessive mutations. Because several genes related to LGMD2 encode the key components of the DAPC, such as α-, β-, γ-, and δ-sarcoglycan, patients with LGMD2 usually have phenotypes similar to those of BMD. In this study, we investigated the LGMD-related genes included in TruSight One by NGS, but found no genetic changes causing the illness in the patient.

In contrast, we found that this patient had*DMD* gene have also been reported as exceptions to the rule^[@CR3],[@CR6]^. In these cases, alternative splicing is considered a factor leading to these exceptions^[@CR3],[@CR7]^.

Recently, another notable mechanism of phenotypic amelioration was proposed.

It is known that premature stop codons in exon 1 of the *DMD* gene, such as p.(Trp3X) and p.(Glu5ValfsX3), resulted in very mild phenotypes of BMD. The first reported case of p.(Trp3X) showed no symptoms until age 20 years and could walk until 62 years of age^[@CR8]^. The patient with p.(Glu5ValfsX3) was ambulant until 42 years of age^[@CR6]^. Gurvich et al.^[@CR6]^ revealed that these truncating mutations in exon 1 induced alternative translation initiation at two AUG codons within exon 6 and resulted in considerable amelioration of the phenotype. Furthermore, Wein et al.^[@CR9]^ demonstrated that the reinitiation of


Open Space, Square". The Arabic word originally meant "horse-racing ground; hippodrome". The etymology of the word equivalent in European languages brings us to Greek and Latin plateau, which was called Agora4 in political situations and Forum5 in Roman politics. The word Meydan has pre-Islamic roots in maita-ni (hippodrome), and in the case of Persian cities, it has been observed that each city had at least one central square, used for trade and public gatherings (Mehan 2016a: 547). Michael Webb, in his book "The City Squares", argues that traditional square has been shaped by commerce and defense, political systems and cultural traditions, climate and topography (Webb 1990: 20). In its most common functional definition, Meydan denoted a public space of social interaction, especially to accommodate the need for temporarywhich has been built around 518 B.C., and hold the great attention in terms of architecture and city planning because of its alleys, streets and public spaces, which indicate an advanced stage of planning of the cities. It appears that the square was built in the vicinity of royal palaces and major political centers and considered as a place for ceremonies and political gatherings. In the pre-Islamic period, particularly at the time of the Sassanid, squares were spaces allocated to religious rituals or official ceremonies. In certain cities they were positioned near royal palaces and gates, and chiefly used for military parades. In this era, Square is a place where bazaars open up so it is not shaped as a "planned" urban element (Habibi 2003: 34). During the


Gideon suggested that the impact of religion on architecture could be explained by man's desire for a prolongation of life and for a constitution of existence after death in ancient Middle Eastern architecture (Giedion 1981: 9). According to Gideon, the joy of celebrating under the sky but within the enclosure of courtyard houses evokes a sense of continuity and eternal existence (Giedion 1981: 138). Based on Sumerian cosmology, the universe consisted of heaven and earth (An-Ki), which was united until Enlil (God of air), se7 See Sussan Babaei "Sacred Sites of Kingship: The Maydan and Mapping the Spiritual Vision of the Empire in Safavid Iran". In Persian Kingship and Architecture: Strategies of Power in Iran from the Achaemenids to the Pahlavis, by Sussan Babaei and Talinn Grigor, 200.city planning were mixed with the traditional layout of the cities. In Traditional Iranian squares, streets entered the space at its corners, leaving the center free for commercial or social activities. However the streets of Renaissance style, entered the square at the middle of its sides, which accommodated traffic and put a visual emphasis on the central point, where a statue or monument could be placed. Therefore, the design of the square was changing according to the principle of central composition, whereby the entire composition revolved around a central point, which now often marked the glory of absolute power. In order to understand the concept of power, Foucault's ideas used to explore power, religious beliefs and national identity through symbolism in architecture and urban design. According to Foucault


Imam Khomeini Square, also called Toopkhaneh Square which is literally means artillery Square), Tehran's main square, 18 august 1953. Source: The Guardian's archive A. Mehan. Blank slate: squares and political order of city318 design to fight 'the barricades,' to make the city and the citadel more defensible against a popular uprising" (Milani 2004). According to Mahvash Alemi: "The square reflects the principal ambitious of the court and is a sort of exhibition hall for new acquisitions: the military reform is perceived through the cannons, the decorations and the nearby drill grounds; the technological innovations are to be seen in the use of gas for illumination, the telegraph, and the tramway; the new source of finance, the Imperial Bank of Persia, is the most important building facing the square"life of the square (Fig. 5). Escape from squares There are some research related to the urban transition in Iran; which all are unanimous that modern movement destroyed heritage urban textures in many of Iranian cities. However, there are few references on the urban transition and evolution process of Iranian public spaces (see Mehan 2016b; Keddie, Richard 2003). By formation of Qajar government in 1786, Iran experienced a new period of global history, social, economic and cultural changes. In the beginning of Qajar dynasty in 18th century, urbanism in Iran was not much different with Safavid era, the bazaar and square were still the backbone of the city, and other urban spaces like mosque, square, and school were its inseparable spaces. Social interactions still took place mainly in


bazaar as a place for refreshments, rest, and exchange of news; actually, it was considered as the focal point of public life as well as center of social, cultural, recreational, religious and political activities. But by the end of Qajar dynasty in 19th century, which coincides with industrial revolution period in Europe, the urban planning in Iran encountered many changes. The most important and significant element of change was the advent of car into urban spaces, which led to establishment of some long and wide streets in heritage urban texture (Kheirabadi 2000). In the process of Modernization, most of squares bearing little resemblance to their earlier counterparts. The new squares were neither the naturally evolved spaces of tradition nor primarily open-ended centers of activity for people. They wereas "courtyards of the city" provokes a spatial archetype: the Paradise. In this sense, paradise is strongly associated with the idea of square as "Blank Slate". By considering the modern foundations for power relations, and their impact on urban form, this article focuses on the transitional history and urban evolution of Iranian public squares through the modern foundation till the contemporary era. Therefore, the design of the square was revolved around a central point, which now often marked the glory of absolute power. In this interpretation, the square as a whole reflects the struggle between sources of power, as each source tries to gain control of the society through showing strong appearance in urban space. In contemporary Middle Eastern experience, the rise to prominence of Shahyad Square (Now


member of the council of the Men of the Trees.

Death and legacy
Croom-Johnson died at age 78 at his home, Hillbrook House, at Trull, near Taunton, Somerset, on 29 December 1957.

Selected publications
 Postage-Stamp Collecting ... Illustrated. Bazaar, Exchange & Mart, London, 1923.
 Stamps of the British Solomon Islands (les timbres-poste des Iles Salomon). Editrice Filatelica (Collana di Pubblicazioni Filateliche 16), Turin, 1928.
 The origin of Stowe School. W.S. Cowell, Ipswich & London, 1953.

References

External links

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Category:Knights Bachelormoments – long enough to get thoroughly saturated.

Rinse the sponge under clean water. Leave it sopping wet for the next step.

Put it on a paper towel in the microwave, and microwave for about two minutes on high. You’ll need to monitor this carefully the first time you do it, since different brands of sponges and microwaves will react differently. Watch for any signs of burning or melting, and turn off the microwave immediately if you see them. If you can’t microwave a particular sponge for more than one minute without signs of burning or melting, try putting it in a dish of water (preferably clear, so you can watch) and put that in the microwave.

Once it’s done, open the microwave door and let the sponge sit for a


House of Cards star Michael Kelly has already lined up another cushy government job: He’s joining the cast of the upcoming Amazon thriller Tom Clancy’s Jack Ryan as a series regular for Season 2, TVLine has learned.

Kelly will play Mike November, a “smart, seasoned career field officer in the CIA” who works with CIA analyst Jack Ryan (played by The Office alum John Krasinski) and Ryan’s boss Jim Greer (The Wire‘s Wendell Pierce) throughout Season 2. Jack Ryan — which debuts Aug. 31 on the streaming service and promises a fresh take on the iconic Tom Clancy action hero — locked down an early second-season renewal back in April. The sophomore season will see Jack Ryan “confront the forces in power in a dangerous, declining democratic regime inother media).

The Search and Directories category remains the main growth area, although since Google refuses to reveal their numbers, the figures remain a significant estimate. However, year on year this category grew by 30% to $807m. In the fourth quarter of 2008, the sector grew by 27% compared to the same period in 2007, to $224m. It also grew by 6% over the third quarter in 2008, which is the critical figure as the 'credit crunch' began to bite during this period.

Of the other 2 monitored categories, Display Advertising grew by 27% in 2008 to $465m and by 24% year-on-year in the fourth quarter, to $130m. Compared to the third quarter in 2008, this marked a 4% growth in advertising spend. Finally, the Classifieds sector grew by 23%


primary landing pages used in a search advertising campaign. Therefore it's instantly possible to see the most popular paths that visitors follow and the most visited pages. By hovering the mouse over the percentage box in the Site Overlay, another box appears that displays the actual number of clicks to that page and the number of conversions to a particular goal on that page.

If the link is clicked upon, the Site Overlay takes you to that next page and then displays the information according to the links from that page. It's therefore possible to see which are the best performing links or pages in terms of click density and what the most popular route to a particular goal is, without necessarily having to set up small qualitative researchComputer networking and telephone connectivity have utilized a terminating connector assembly design designated as RJ45 and RJ11 respectively. “RJ” standard for Registered Jack illustrated by RJ11 and RJ45 plugs and jacks. RJXX is a general term for multiple electrical connector designs used for telephone and data, including the RJ11, RJ14, RJ25, RJ48, RJ61 and RJ45 connectors. The numbering and pinouts were set forth by the Bell System as the Universal Service Order Code (or Universal Service Ordering Code)(USOC). They are also registered with the U.S. Federal Communications Commission (FCC), under 47 C.F.R. § 68.502. Though these RJXX connectors vary in the number of pins or electrical connections per connectors, they are all characterized as generally rectangular assemblies having a given number of parallel connectors. The male connector has


whose output response (e.g., voltage, gain, power, etc.) exhibits some undesirable variation over time. Also, the variation of this output response or gain may increase over some time period, decrease over some time period, or increase and decrease at points over a time period. The common problem is that of how to control (or compensate for) the time variable output response in order to render the desired output response. Generally, the desired output response is constant or flat over some period of time for the system at issue. Sometimes, a non-flat response may be desired.
Other problems and drawbacks also exist.
An embodiment of the present invention comprises a voltage regulator including a droop compensation circuit and a voltage regulator circuit. The droop compensation circuit compensates for an output thatvoltage output in order to quicken recovery.
Accordingly, it is one object of the present invention to overcome one or more of the aforementioned and other limitations of existing systems and methods for regulating voltage supplied to an electronic circuit, such as a transistor-based preamplifier circuit or amplifier circuit.
It is another object of the invention to provide a voltage regulator that solves or mitigates the problem of droop in electronic circuits.
It is another object of the invention to provide a voltage regulator that solves or mitigates the problem of droop so that COTS RF transistors can be used in the regulator load without special screening procedures.
It is another object of the invention to provide a voltage regulator for use in high stability radar systems so that the system response


have refused to take in a single person under a plan agreed in 2015 to relocate 160,000 asylum-seekers from Italy and Greece, which had been overwhelmed by mass influx of people from the Middle East and Africa.

Poland’s Interior Minister Mariusz Blaszczak was quoted as saying on Monday by the state news agency PAP: “We believe that the relocation methods attract more waves of immigration to Europe, they are ineffective.”

The Czech Republic had initially taken in 12 people from their assigned quota of 2,691, but said earlier in June it would take no more in, citing security concerns.

A series of deadly Islamist attacks in western Europe since late 2015 has put the spotlight on public security and the easterners say hosting people from the mainly-Muslim Middle East and Northand what they can't cover, they try to keep calm; and I have some bits and pieces of info on people getting sick and how that affects a company, that show that my situation is no worse than that of others, just in case anybody tried to kick me out (which hasn't happened yet, because the support I get is just awesome).

A:

Some employers are cool with this. They will arrange to have a way to cover if you're suddenly out of commission for a few days on no notice. It's worth it to have you on the team. Some are not. I don't think a company will change their position on this organically - if you current employer is getting annoyed every time you're out sick, they aren't


right role for you.  Research other options or other companies.
Quite a few of these tips involve disclosing your condition to the boss.  This is where I delicately move around the "it depends, get a lawyer" issue - in the US, there's a lot of health conditions that are protected by law, and with the help of a doctor's diagnosis and some legal consultation, you can ask for accommodations that allow you to succeed at work so long as what you ask for is reasonable for the business that employs you.  Mileage varies remarkably here - and it is a legal and cultural thing whether or not you want to admit to a given health condition in a given country.

well with these macros
#if SERIAL_PORT == 0 && (AVR_ATmega2560_FAMILY || AVR_ATmega1284_FAMILY)
  static const char RXD_NAME[] PROGMEM = { "RXD" };
  static const char TXD_NAME[] PROGMEM = { "TXD" };
#endif

/////////////////////////////////////////////////////////////////////////////

// second pass - create the array

#undef _ADD_PIN_2
#undef _ADD_PIN
#undef REPORT_NAME_DIGITAL
#undef REPORT_NAME_ANALOG

#define _ADD_PIN_2(ENTRY_NAME, NAME, IS_DIGITAL) { ENTRY_NAME, NAME, IS_DIGITAL },
#define _ADD_PIN(NAME, COUNTER, IS_DIGITAL) _ADD_PIN_2(entry_NAME_##COUNTER, NAME, IS_DIGITAL)
#define REPORT_NAME_DIGITAL(COUNTER, NAME) _ADD_PIN(NAME, COUNTER, true)
#define REPORT_NAME_ANALOG(COUNTER, NAME) _ADD_PIN(analogInputToDigitalPin(NAME), COUNTER, false)

typedef struct {
  const char * const name;
  pin_t pin;
  bool is_digital;
} PinInfo;

const PinInfo pin_array[] PROGMEM = {

  /**
   *  [pin name]  [pin number]  [is digital or analog]  1 = digital, 0 = analog
   *  Each entry takes up 6 bytes in FLASH:
   *     2


SERIAL_PROTOCOLPGM("   compare interrupt enabled"); }
static void err_prob_interrupt() { SERIAL_PROTOCOLPGM("   overflow interrupt enabled"); }

#if AVR_ATmega2560_FAMILY || AVR_AT90USB1286_FAMILY
  static void print_is_also_tied() { SERIAL_PROTOCOLPGM(" is also tied to this pin"); SERIAL_PROTOCOL_SP(14); }
#endif

void com_print(uint8_t N, uint8_t Z) {
  const uint8_t *TCCRA = (uint8_t*)TCCR_A(N);
  SERIAL_PROTOCOLPGM("    COM");
  SERIAL_PROTOCOLCHAR(N + '0');
  switch (Z) {
    case 'A':
      SERIAL_PROTOCOLPAIR("A: ", ((*TCCRA & (_BV(7) | _BV(6))) >> 6));
      break;
    case 'B':
      SERIAL_PROTOCOLPAIR("B: ", ((*TCCRA & (_BV(5) | _BV(4))) >> 4));
      break;
    case 'C':
      SERIAL_PROTOCOLPAIR("C: ", ((*TCCRA & (_BV(3) | _BV(2))) >> 2));
// Conservative estimate on the lower/upper bound of the number of
  // calls allowed.
  virtual int ConservativeLowerBound() const { return 0; }
  virtual int ConservativeUpperBound() const { return INT_MAX; }

  // Returns true if and only if call_count calls will satisfy this
  // cardinality.
  virtual bool IsSatisfiedByCallCount(int call_count) const = 0;

  // Returns true if and only if call_count calls will saturate this
  // cardinality.
  virtual bool IsSaturatedByCallCount(int call_count) const = 0;

  // Describes self to an ostream.
  virtual void DescribeTo(::std::ostream* os) const = 0;
};

// A Cardinality is a copyable and IMMUTABLE (except by assignment)
// object that specifies how many times a mock function is expected to
// be called.  The implementation of Cardinality is just a


Rusty (band)

Rusty is a Canadian alternative rock band formed in 1994 in Toronto, Ontario, Canada.  The band earned a 1996 Juno Award nomination in the category Best Alternative Album for Fluke.

History
Rusty's origins are in One Free Fall, a band from Wolfville, Nova Scotia who moved to Toronto in 1988. That band's core members were vocalist Ken MacNeil, guitarist Sandy Graham, bassist Jim Moore and drummer Bob Vespaziani. That band signed to independent label Handsome Boy Records, released the album Mud Creek in 1993 and collaborated with Art Bergmann on a cover of "Prisoners of Rock 'n Roll" for the Neil Young tribute album Borrowed Tunes: A Tribute to Neil Young, but broke up in 1994 before achieving any notable success.

Following their breakup, MacNeil, Moore and Vespaziani hookedthe forecasting of cosmological constraints.

The resulting selection function is shown in Fig. \[fig:selfun\] for the two luminosity–temperature relations (see Sect. \[lumtempevol\]) we consider. Note that the selection function in regions where we have not calculated it explicitly is extrapolated from the region where we have done so. Hence, its features in those extrapolated regions should only be considered a rough indication of its behaviour, particularly in the high-redshift, high-temperature region. This region is only relevant for including measurement errors, and since such high-temperature clusters are exceedingly rare, the uncertainty in this part of the selection function has no significant impact on our results[^4].

### Uncertainty

[ The shape of the selection function is dependent on the cluster model employed, as described above. It is well known that clusters of galaxies have a


population is a simplification based on mean observational values of cluster-model parameters, and as a result will have somewhat differing detection properties compared to a real sample. To characterize such uncertainty requires modelling of the cluster-model parameter distribution, and the selection function dependence on those parameters. However, once such information becomes available, it will be included in the analysis and hence remove/reduce such uncertainty. As we do not currently have a realistic model of the cluster parameter distribution, we have determined the impact of assuming extreme structural cluster parameters, and found that at most the typical selection function uncertainty is of the order of $10$ per cent. These results agree with those of @Burenin07 for the 400d survey, which show that reasonable variations in cluster size, morphology andof the clusters. It is worth noting that the change in detection probability is slow as a function of X-ray temperature, and hence the concept of e.g. a single flux limit (which would correspond to a sharp transition between one and zero in the probability) is not suitable for defining the XCS sample. The underlying reason for this is that the [*XMM*]{} archive images occupy a range of different exposure times, hence individual flux limits. Caution is therefore advised when comparing Fig. \[fig:xlimits\] to similar plots based on a single flux or mass limit. For comparison, using ${\rm P}({\rm detection})\ge 0.05$ to define the detection limit leads to a flux limit of $\sim 5 \times 10^{-14}$ erg s$^{-1}$ cm$^{-2}$, considerably lower than that shown in Fig. \[fig:xlimits\].

### With measurement errors {#Distriberr}

Introducing measurement errors


possible constraint improvement. Taking error and contamination effects into account, it is likely that there would be only a weak improvement by including those XCS clusters expected to have a photon count below $500$. However, follow-up observations with e.g. [*XMM*]{} or [*IXO*]{} (formerly [*XEUS*]{}) could improve the photon statistics of those clusters enough to make their inclusion in the analysis worthwhile. We discuss this in more detail in Sect. \[Conclusions\].

### Self-calibration of $L$–$T$ relation, with scatter

Self-calibration is the process by which e.g. the $L$–$T$ relation can be constrained jointly with cosmological parameters using only the ($T,z$) cluster number counts [@Hu; @LHI; @MJ04; @LH].

\

\

[|c|c|c|c|c|c|]{} $L$–$T$ evolution & & Realistic $T$ errors & Worst-case $T$ errors & Realistic $z$ errors & Worst-case $z$ errors\
Constant &

  ------------------
   $\Omega_{\rm m}$
constant $L$–$T$ case to be most representative of the constraints we can expect. As expected, the constraints on $\Omega_{\rm m}$ and $\sigma_8$ degrade when marginalizing over the four $L$–$T$ parameters (compared to Fig. \[fig:contours\]), but still remain relatively small. In comparison to the South Pole Telescope, [*Planck*]{}, and [*DUET*]{} [@MJ04; @Geisbuesch_planck], our constraints are still competitive (we lack comparable results for [*XMM*]{}–LSS, but expect to do better given our larger survey area and depth). However, if we were to consider self-calibration of the $M$–$T$ relation as well (rather than using an external description, as described in Sect. \[tempmass\]), those surveys would have more power than the XCS (using only archival [*XMM*]{} data) through the use of the cluster power spectrum [@MJ04; @LHI]. In fact, we do not expect XCS to


overestimation of $\Omega_{\rm m}$. Comparing the second, third and fourth cases, we can see that $L$–$T$ evolution and scaling-relation scatter all have a similar effect when unaccounted for, all leading to an overestimation of $\sigma_8$ (and consequently underestimation of $\Omega_{\rm m}$). As they both have a similar effect, the self-similar evolution in the fifth case can mimic some of the unaccounted-for scatter, leading to a lesser overestimation than for the previous cases. On the other hand, the sixth and last case combines the two effects thus leading to a dramatic overestimation of $\sigma_8$. As such, this last case represents a worst-case scenario for this type of bias.

![Expected $68$ and $95$ per cent parameter constraints from the $^{500}$XCS, for various mass–temperature-relation assumptions inconsistent with the fiducial model used forthe selection function requires the specification of the luminosity–temperature relation, and thus enables us to also self-calibrate this relation. We also introduce and motivate a new ‘smoothed Maximum Likelihood estimate’ of the expected constraints, which can be regarded as intermediate between a Fisher matrix analysis and a full mock catalogue ensemble averaging in MCMC.

We expect the $^{500}$XCS to measure $$\begin{aligned}
\nonumber
\begin{array}{lcrrclcrr}
  \sigma\left(\Omega_{\rm m}\right) & < & 0.03 & (10\%)\,, & & \sigma\left(\alpha\right) & < & 0.12 & (6\%)\,, \\
  \sigma\left(\sigma_8\right) & < & 0.05 & (6\%)\,, & & \sigma\left(\beta\right) & < & 0.33 & (13\%)\,,
\end{array}\end{aligned}$$ for a flat $\Lambda$CDM Universe, the uncertainty on $\Omega_{\rm m}$ also being that on $\Omega_\Lambda$. The cosmological constraints are similar to those already obtained using gas mass fraction measurements [e.g. @Allen02; @Allen:2007ue].


out, and obtained some first results [@XMMLSSfirst]. A potential pitfall however is the possible redshift evolution of the $L$–$T$ scatter, as observed in the CLEF simulation [@Kay07]. This has not so far been considered in the literature, but is a possible source of bias that should be better understood. The future [*IXO*]{} mission [@XEUS] will be of great importance for precision measurements of all details of the $L$–$T$ relation. The XCS will provide thousands of clusters for [*IXO*]{} to target.

An important source of uncertainty is the mass–temperature relation. We have shown quantitatively that, as for the luminosity–temperature relation, imperfect knowledge can easily lead to significant bias. Joint estimation of the mass–temperature relation will lead to broader constraints, and we do not expect the XCS to be able to& & \times \Theta\left(m_L\sigma_{\log L_{\rm X}} -
  |\log_{10}L(T,z) - \log_{10}L_{\rm t}|\right)
    {\rm d}\log_{10}L_{\rm t} \,.\end{aligned}$$ The parameters $m_T$, $m_L$, $\sigma_{\log T}$ and $\sigma_{\log L}$ are described further in Sections \[tempmass\] and \[lumtemp\] as well as Table \[tab:scalrel\].

### Measurement errors {#clustcnterr}

When treating the case of measurement errors in $T$ and $z$, we must distinguish observed and true temperature. The expected number of clusters between *observed* temperatures $T_1$ and $T_2$, and redshifts $z_1$ and $z_2$, is given by $$\begin{aligned}
  N_{\rm obs}(T_1, T_2, z_1, z_2) & = & \int_{z_1}^{z_2} \int_{T_1}^{T_2}
  \overline{n}(T, z) {\rm d}T {\rm d}z\end{aligned}$$ where $\overline{n}$ represents the cluster distribution marginalized over the probability distribution for measurements, i.e. $$\begin{aligned}
  \nonumber
  \overline{n}(T, z) & = &
  \int_{z_{\rm t}} \int_{T_{\rm t}}


$\left\langle\ln{\cal
L}\right\rangle$ comes from the difference in the first sum. Naively, we would not expect this to differ much between the two cases, particularly for a binning that represents the distribution well. What would be the expected value? Consider the following quantity: $$\begin{aligned}
s_{\rm rel} \equiv \frac{\sum_i a_i\lambda_i^*}{\sum_i
a_i\left(\lceil\lambda_i^*\rceil-\frac{1}{2}\right)} =
\frac{\sum_i a_i \lambda_i^*}{\sum_i a_i \left(\lambda_i^* +
(\lceil\lambda_i^*\rceil-\lambda_i^*)-\frac{1}{2}\right)} \,.\end{aligned}$$ One would generally expect that $(\lceil\lambda^*\rceil-\lambda^*) \in
U(0,1)$ or at least a similarly symmetric distribution across the bins, so that $\left\langle
\lceil\lambda^*\rceil-\lambda^*\right\rangle = 1/2$. We thus expect $$\begin{aligned}
\left\langle s_{\rm rel} \right\rangle =
\frac{\sum_i a_i \lambda_i^*}{\left\langle\sum_i
a_i\left(\lceil\lambda_i^*\rceil-\frac{1}{2}\right)\right\rangle} =
\frac{\sum_i a_i \lambda_i^*}{\sum_i a_i \lambda_i^*} = 1 \,.\end{aligned}$$ For typical XCS catalogues, even if we assign uncorrelated random exponents $a_i$, the probability distribution for $s_{\rm rel}$ is quite generally very sharply peaked at or close to $s_{\rm rel}=1$. An example is shown in+++
hook = "UNWRITTEN. This should not appear on the front page."
published_at = 2016-01-25T06:12:05Z
title = "Heavy complexity"
+++

The article [_the Sad State of Web Development_][article] may hyperbolic to the
point of excess, but it's more right than it is wrong. It's all too often these
days that I realize I need twenty gems to get a Ruby web app up and running, or
that installing a project's frameworks takes ten times as long as the bug fix
that I'd set out to accomplish, or that I can finish an app without a framework
in a quarter of the time it would've taken me to read its "quickstart" docs.

The author gets to the heart of the problem here:

> Javascript has zero standard library, so as soon as you npm init a new Node
> app you better


install at least 15 terabytes of modules to get 1/16th the
> standard lib of something like Ruby or Go.

The wider programming community hasn't yet fully realized the collateral damage
of an overly minimal or poorly designed standard library. While it sounds like
a noble principle that the community should be empowered to create its own
solutions, this leads to an inevitable fracturing of techniques that will never
be resolved. The generation of popular dynamic languages like Ruby, JavaScript,
and Python thought that they were solving the mistakes of their predecessors by
being largely "batteries included", but they didn't go far enough. They also
got their interfaces wrong; best demonstrated by the HTTP libraries of both
Python and Ruby.

Finding that perfect balance between functionality and simplicity is incredibly
difficult, and nobody's gotten it right so far [1]. As(a) -1/775  (b) -60794  (c) -4
a
What is the second smallest value in 11, 1/8, 1633, -4?
1/8
What is the second biggest value in 11, 2/3, -3, 2/35, 5, 0.01, -6/5?
5
Which is the fourth biggest value?  (a) -20  (b) -1  (c) 2/5  (d) -1/5  (e) 15/209  (f) -0.4
f
Which is the fourth smallest value?  (a) -0.3  (b) -11  (c) 8  (d) -187  (e) -2/17  (f) 1045
e
What is the third biggest value in -77, 0.2, 0.4, 1/4, 18/7, -2, 2/7?
2/7
What is the second smallest value in 0.2, -1396, 2413?
0.2
Which is the fifth smallest value?  (a) -0.2  (b) -69  (c) 4  (d) -1/2  (e) 22650  (f) 0.5  (g) -3
f
Which is the third


oh, man, at the moment the hand wraps started to come on… because I had never even had that happen before! Nobody’s ever wrapped my hands with tape and gauze and everything, and I’m like, ‘Oh, guess this is real! There’s no backing out now.'”

In the lead up to Tonon’s debut, there was, of course, some stand-up sparring. But, he notes, that obviously isn’t the same as a full-fledged fight.

“Maybe I did like a little bit of sparring here and there, but, you know, it’s like getting hit with pillows. It’s a little scarier when it’s somebody’s closed fists, and it’s those tiny gloves,” said Tonon.

By facing that fear during his debut, a fight against the Philippines’ Richard Corminal, Tonon was elated.

“I remember after the first fight saying,this, that or the other thing. It’s like, ‘Dude, okay, but he’s also getting his face punched, and before that, the reason he’s mounted is that he took a huge shot and almost got knocked unconscious. You can’t exactly put that dude in the same category as a guy who gets mounted in a jiu-jitsu competition. You just can’t.”

Predicting the outcomes of the ONE Lightweight Grand Prix

Despite recently moving down to ONE Championship’s featherweight division (155 pounds), Garry Tonon is very cognizant of the ONE Lightweight Grand Prix, which takes place in his original division (170 pounds).

The Grand Prix features some of ONE’s top lightweight talent, including Japanese icon, Shinya Aoki; the recent, marquee signee, former UFC lightweight king Eddie Alvarez; the Philippines’ Eduard Foloyang; and striking ace,


don’t know. That fight really confused me. I feel as though sometimes there’s just an inconsistency in Shinya’s performances.”

But don’t get Tonon wrong. If Aoki’s on point, he could give Alvarez a world of trouble. Aoki does, after all, hold a submission win over Alvarez.

“I could be wrong. I think that if Shinya executes a great game plan and does the things that I told you before: you know, focuses on setting up his takedown and works on controlling Eddie on the ground and working for a submission, or TKO, or something, I think he gives Eddie a hell of a fight and it could be tough. I think that it’s possible that he could win.”

“It could definitely go the other way, but if I had to putreturn to Australia for their last two league matches against Australia in Sydney on March 8 and against Scotland in Hobart three days later.

"It would have been nice to have finished New Zealand before coming to Australia," team manager Michael de Zoysa said. "It certainly is inconvenient and tiring for the boys."

Zoysa said with Friday spent in travelling, the team is likely to rest on Saturday which leaves them little time for serious training ahead of the England game.

The match against Eoin Morgan's side will be Sri Lanka's third in eight days, having played Afghanistan last Sunday and Bangladesh on Thursday.

In contrast, defending champions India are enjoying a relaxed itinerary.

Mahendra Singh Dhoni's men played their first two matches a week apart, clashing with Pakistan in Adelaide on February