presents the additional difficulty of controllably creating and manipulating multiple superconducting vortices. This has led to renewed interest in the original Kitaev idea[@Lutchyn; @Oreg; @Beenakker], where Majorana particles are shown to be localized at the ends of a one-dimensional $p_x+ip_y$ superconducting wire. In an interesting recent paper, this setup has been examined in great detail, including explicit plans to manipulate, braid, and measure these Majorana end states[@Alicea]. All previous discussions of Majorana end states, with one exception [@Comment_Beenakker], assume that an effective one-dimensional band can be created by occupying only the lowest transverse sub-band of a quantum wire. This again presents formidable technical challenges. In this paper we move beyond the strict one-dimensional limit, and explore further the notion of Majorana end states in *quasi*-one dimensional $p_x+ip_y$ superconductors.with electrostatic gates, or by controlling domain walls in the Ferromagnetic insulator. For example, an effective $p_x+ip_y$ region can be created at a domain wall separating two regions of opposite in-plane magnetization. Our results raise the exciting possibility that Majorana fermions could be realistically implemented in microstructures defined by conventional lithography techniques, and could be efficiently manipulated and braided simply by electrostatic gating or other means.

*Acknowledgements -* We thank Jason Alicea for many helpful discussions and thank Hugo Dil, Roland Kawakami and Jagadeesh Moodera for discussions on the materials aspect. This work was supported by DOE DE–FG02–03ER46076 (PAL) and NSF IGERT DGE-0801525 (ACP).

A. Kitaev, arXiv:cond-mat/0010440 (2000). N. Read and D. Green, Phys. Rev. B [**61**]{}, 10267 (2000). D.A. Ivanov, Phys. Rev. Lett. [**86**]{}, 268 (2001). C. Nayak, S.H.


smooth edge disordering are similar to those of bulk onsite disorder: increasing $\sigma_W$ decreases the bulk excitation gap by mixing transverse sub-channels. However, for moderate $\sigma_W$ the Majorana end-states survive and continute to appear and dissapear in an alternating fashion as $\mu$ is swept.[]{data-label="fig:MeanderingEdgeSpectra"}](AppAMeanderingEdgeExcitationSpectrum.eps){width="3.5in"}
study is that NGF influences the elaboration of primary dendrites by sympathetic ganglion cells only during a critical developmental period. In maturity, NGF acts as a "maintenance" factor necessary for normal neuronal function and survival, but neurons lose the capacity to respond with wholesale rearrangements of dendritic architecture.


Q:

WebGL code not working- blank page

I´ve started working with WebGL and javascript in these last few days and I´ve stumbled across a problem that I have no idea how to solve.I don´t know why, but everytime that I´m trying to run this program a html opens with nothing unless a blank page.The program should be drawing points when I click on the screen.

 //ClickedPoints.js
 //Vertex shader program

 var VSHADER_SOURCE =
   'attribute vec4 a_Position;\n' +
   'void main() {\n' +
   ' gl_Position = a_Position;\n' +
   ' gl_PointSize= 10.0; \n' +
   '}\n';

 //Fragment shader program

 var FSHADER_SOURCE =
   'void main() {\n' +
   'gl_FragColor= vec4(1.0,0.0,0.0,1.0);\n' +
   '}\n';

 function main() {

   //Retrieve <canvas> element

     raw1.reset();

            raw2.reset();
        }
    }

    /**
     * @throws Exception If failed.
     */
    @Test
    public void testParseContinuousSplit() throws Exception {
        ByteBuffer tmp = ByteBuffer.allocate(10 * 1024);

        GridClientCacheRequest req = new GridClientCacheRequest(CAS);

        req.key("key");
        req.value(1);
        req.value2(2);
        req.clientId(UUID.randomUUID());

        for (int i =


Two men, who were arrested in connection with the death of Christopher Nevin, appeared at Navan Court this morning, charged with assault, causing harm.

Judge Grainne Malone refused bail in the cases of Josh Turner and Wayne McCluskey, both with addresses at Mooretown, Ratoath.

Turner (23) and Cluskey (24) are both charged with assaulting Christopher Nevin, causing him harm at Tailteann Road, Navan on 19th November last.

Judge Malone was told further serious charges were likely to follow in both cases.

Both men were remanded in custody to Clover Hill Court next Tuesday.

Background
==========

The Health Information Technology for Economic and Clinical Health (HITECH) Act and the American Recovery and Reinvestment Act (ARRA), enacted in 2009, promote the adoption of health information technology by hospitals (and other health delivery care organizations) and care providers \[[@B1],[@B2]\]. Health information technology (HIT) is defined as "a variety of electronic methods used to manage information about people's health and health care, on both the individual and group level" \[[@B3]\]. The goal of these federal policies is to promote the use of HIT-based information in a way that improves care delivery and health outcomes (i.e., meaningful use) \[[@B2],[@B4]\]. Meaningful use of HIT includes improving coordination and quality of care and engaging patients and families in the care delivery process \[[@B5]-[@B7]\]. Potential benefits include the improvements of individual


are community health centers that provide primary care services to vulnerable and underserved populations in rural and urban areas. One study reported that health centers serving the most vulnerable patients were less likely to have HIT systems, and among those with these systems, only 50% had the minimum set of functionalities \[[@B19]\].

In order for FQHCs' to absorb the expected increase in demand and improve quality of care, they must leverage HIT as a tool for improving service delivery and patient outcomes \[[@B2],[@B20]\]. Given the potential benefits of HIT, there is a need to examine the availability of HIT at health care organizations that predominantly serve underrepresented populations, as well as associations between HIT capacity and performance. Particularly, the essential role of health centers in providing health care tothat the HIT system has been in place \[[@B42],[@B43]\]. It may be that FQHCs, with better quality of care, had more favorable operating environments, whether financial or otherwise, and were better positioned to adopt HIT and implement advanced functionalities.

Because our study used a facility survey, we were unable to control for possibly relevant variables such as patient age, socioeconomic status or clinical indicators. Although we used the best available measures and accounted for proportion of minority and Medicaid patients served by the health facilities, these measures may not have been adequate. Additionally, the absence of case mix and other factors by level of HIT capacity could also have resulted in missed small differences between lower and higher capacity adopters of HIT. Given the promise of HIT as a


mechanism for improving quality of care and health outcomes, especially for vulnerable populations, the information presented in this study is an important step to identifying areas for further empirical examination and improvement.

Conclusion
==========

The American Recovery and Reinvestment Act of 2009 (ARRA) investment in health information technology was enacted with the expectation that HIT would improve the care delivery process and quality of care. We examined the relationship between HIT capacity in FQHCs and quality of care and found a positive association between greater HIT capacity and quality of care, measured by receipt of discharge summaries, patient reminder systems for preventive services and follow-up care, and timely appointment for specialty care. Considering the promise of HIT as a tool for improving quality of care, systematic examination of organizational structure andoutboard containers to sag a bit due to inadequate support for them when the loaded carrier is lifted by the carrier's handholds.
There is a continuing need for a carrier that is comfortable to carry, allows for excellent visibility of the product in the containers and the labels on the containers, allows for easy application and removal of the containers from the carrier, provides good balance in carrying and handling containers, and that readily lends itself to nested stacking of multiple carriers for compact shipping and ease of loading into and handling by high speed mechanical applicators.


The retailer is promising thousands of Black Friday deals on electronics, tech, beauty, baby and home departments, with hundreds of independent sellers also offering discounts at Amazon Marketplace and Handmade at Amazon during the shopping bonanza.

Getting the ball rolling, customers looking for a bargain could make some big savings on Christmas presents with up to £40 off on the Fire 7 kids tablet and Fire 8 HD Kids tablet from November 17.

The 'Amazon Black Friday Deals Store' will open from midnight on Friday, November 17 until 23:59 on Sunday, November 26 and will include Deals of the Day - every day throughout the period, ranging from Amazon devices, electronics and pet supplies to kitchen and home and garden items - and Lightning Deals - products available at av. Callaway Bank (In re Meritt), 7 B.R. 876 (Bankr.W.D.Mo.1980); In re Hall, 14 B.R. 186 (S.D.Fla.1981).
*52 A separate final judgment will be entered in accordance with the foregoing.


wide range of professional achievements to their credit. Notable names include Pakistan’s foremost nuclear physicist Dr. Samar Mubarkmand, leading journalist Dr. Moeed Pirzada and politician Shah Mehmood Qureishi.
This is the first time that such event has been held in Pakistan to honour and acknowledge the academic achievement of UK graduates. Similar events will be held in Karachi and Lahore later this month to honour the UK alumni across Pakistan.
The British Council, in collaboration with British High Commission, is committed to supporting higher education in Pakistan. Each year, the British Council administers a number of scholarships like Chevening, Charles Wallace fellowships and Commonwealth scholarships. Under Chevening Scholarships programme alone, over £550,000 was spent to send 23 Pakistani scholars to the UK last year in September for a one yearwill be rewarded with an immediate bonus with our “Bonus Rozana Program” and you’ll be automatically entitled to the “Bonus Mahana Program” also. The more you spend, the more you get. Keep using your Warid connection and keep winning!

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perfectly picturesque scene taken from your powerful camera. Your Cover picture is the window to your soul.

Update Your Info

If there is, any other moment in time to update your personal information, then the time is now. That’s right. When someone looks at your profile, one of the first things that can be seen is your information, such as your place of work, your family, and non-family relationships, your language of expertise, educational achievements, and more. Nope, you do not need to update other sensitive details, as about 4 or 5 items will be shown at front. You can do this by clicking the “Update Info” button under the cover picture. Do not be surprised, as the update info section has also been improved, with that tile look.

To Showexpenditures, it would be spending millions of dollars on militarisation by 2030. This will lead to slow growth rate of development in economy and a poor graph performance on literacy rate.

To take responsibility and to manage Pakistan’s natural resources, it is important that the government takes action now. Planning for a better future which will not only be environmentally secure but also politically viable, the experts should be paid heed to in the policy making circles. Already the region of South Asia is of global strategic importance to the superpowers. It is not just the oil, gas and petroleum that make this area politically sensitive, but on a scientific level too, the predictions are a bit frightening.

Hence, the solution that comes first to mind is to make policies


subscribers in 2010 said that figure (Sent plus Received) would approximately be 350.785 billion (twice the 175.393).

This analysis of Y2010 is based on the 12 months data from January 2010 to December 2010, so the percentage error is reduced due to minimum estimations in the analysis.

As per our study, the SMS traffic was exchanged at an average rate of 12.8 Paisa (Rs. 0.128) per SMS in the year 2010. The rates of SMS have generally being reduced from the previous year, which stood at 27 Paisa (Rs. 0.27), showing reduction of 47 percent YoY.

Almost 20 percent of the SMS traffic is estimated to be exchanged over flat rate. All the operators have offered different flat rates.

All cellular operators offered attractive SMS-bundle packages, which is approximately 80% of thewill be able to avail free minutes upon changing his/her tariff plan.

Existing subscribers cannot avail this offer.

100 Free Minutes cannot be used to make Off-Net calls, International calls, SMS, MMS, balance share and rental payments.

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= 5*h - 150805*p + 36 for h.
-4
Solve -8 = 4*w - v + 3, 7 = 4*w + 5*v for w.
-2
Solve 97*z - 92*z = 50, -3*o = -o - z for o.
5
Solve 2*g = -5*x + 65, -2*g + g - 5*x + 60 = 0 for g.
5
Solve 107*p + 2*g + 18 = 110*p, -5*g - 40 = -5*p for p.
2
Solve u = -5*i, 11*u = 13*u + i for u.
0
Solve -5*t + 42 = -3*o, -3*o + 48 = 112*t - 107*t for o.
1
Solve -5*b + 2 = 2*q, 0 = -2*b + 3*q - 1464 + 1461 for b.
0
Solve 0 = -n - 31, -2*i = n - 341 + 372 for i.
0
Solve -3*j - 5*y - 22 = 0, 0 = 5*jJean-Pierre Sabarot, company founder

1903

1907

Brives mill

The company centenary, 1919

50-60's

1958

1971

1985

Our history

In 1819, Jean-Pierre Sabarot settled in Haute-Loire (France) buying a mill: this is the birth of the company.
At the end of the 19th century, the company is oriented towards sorting and sale of the famous Le Puy green lentil. The activity naturally extended to a range of quality pulses and cereals.
The company, wishing to develop the richness of its region, sells for 30 years wild mushrooms and develops its sectors worldwide.
Since 1996, Sabarot manufactures and sells canned snails. The company has become the European leader in this sector.

Today, the 7th generation is in charge and perpetuates the ancestral know-how which made the fame of Sabarot.
This expertise, the rigor, advanced technologies, qualitative approaches, the selection of suppliers and certification allowed Sabarot


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urday evening on his way to Pueblo, on
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a journey from Galveston to Chicago on
which he claims to have won a 1 1.000
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says, on a wager of f 1,000 a side, the
conditions being that be is to make his
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ruddy complexion, capablewas trouble 1 with csUirh for seven
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{
        // Handle file data like:
        // file.path
        // file.name
    });
    form.on('end', function() {
        //show complete
    });
    form.parse(req, function(error, fields, files) {
        // create thumbnail images
        // return response
    });
}

On server(nodejs) create a thumbnail image using imagemagick and store it in a folder which can be located anywhere.
Send the saved (image and thumbnail) links back in the response.
Create a image tags and use these links in theIce Cube) before meeting Eazy-E in 1987 and co-founding Ruthless Records with him. Ruthless would go on to sell over 100 million albums from artists NWA, Bone Thugs-n-Harmony, The DOC, Michel'le, JJ Fad, as well as Eazy-E.

The label began to splinter after NWA broke up in 1991. Ice Cube and Dr. Dre left the label and released dis tracks towards Jerry Heller and Eazy-E, blaming Heller as the reason for the breakup. "The split came when Jerry Heller got involved. He played the divide and conquer game. Instead of taking care of everybody, he picked one nigga to take care of and that was Eazy. And Eazy was like, 'I'm taken care of, so fuck it' said Dr. Dre in an interview. ""It's a case of divide and


A polyclonal antibody to protein disulfide isomerase induces platelet aggregation and secretion.
Monoclonal mouse antiplatelet antibodies against a variety of platelet surface components can activate platelets, causing platelet aggregation and secretion. The mechanism involves binding of the Fab domain to a platelet surface antigen, and the activation occurs through an interaction of the Fc domain with the platelet FcgammaRII receptor. There is almost no information on FcgammaRII receptor-dependent activation of platelets by polyclonal rabbit antibodies. We presently report that a polyclonal rabbit antibody to a platelet surface antigen, protein disulfide isomerase, induces platelet aggregation and secretion. These effects are seen with concentrations of the antiprotein disulfide isomerase antibody as low as 25 to 40 microg/mL. Fab and F(ab')2 preparations of the rabbit antiprotein disulfide isomerase antibody do not causeGreen synthesis and evaluation of silver nanoparticles for antimicrobial and biochemical profiling in Kinnow (Citrus reticulata L.) to enhance fruit quality and productivity under biotic stress.
Green synthesis of silver nanoparticles (AgNPs) by utilising plant extract is an emerging class of nanotechnology. It revolutionizes all the field of biological sciences by synthesizing chemical free AgNPs. In the present study, AgNPs were synthesised by utilising Moringa oleifera leaves as the main reducing and stabilising agent and characterised through UV-visible spectroscopy, zeta analyser, X-ray diffraction spectroscopy (XRD), energy dispersive X-ray (EDX), and scanning electron microscopy (SEM). The different concentrations of biosynthesised AgNPs (10, 20, 30, and 40 ppm) were exogenously applied on the already infected plants (canker) of Citrus reticulata at different day intervals. The AgNPs at a concentration of 30


Q:

Get the Domain or Host name and Port in Configure of Startup.cs

I'm in need of help in getting the host/domain name and port of my application.
So far, here's my sample code in my Configure method inside the Startup.cs:
public void Configure(IApplicationBuilder app, IHostingEnvironment env)
{
    var url = ""; // something that will get the current host/domain and port of the running applicaiton.

    RecurringJob.AddOrUpdate<ISomething>(i=>i.SomethingToExecute(url), Cron.Daily);
}

Because I need to pass the url string to my SomethingToExecute method
public class Something : ISomething
{
    public void SomethingToExecute(string url){
        ...
        Debug.WriteLine(url)
    }
}

A:

According to this Github Issue and response from the ASP.NET Core team:

It's not possible. You needdug at a higher or lower elevation, requiring anyone passing through to contort and squeeze their way by. Erdstall tunnels are also notable for having only one point of entry and exit, usually tucked away in the footprints of old settlements, or even hidden in the wilderness. This feature made the air flow through the tunnels nearly non-existent.

A child squeezing through a vertical erdstall slip out. (Image: OgreBot/Wikipedia)

The single most common trait among erdstall tunnels is a sense of mystery. While it is likely that such tunnels were created during the Middle Ages, as far back as the 12th century, the complete lack of archaeological signifiers found in the barren underground passages makes them difficult to date. In addition, the historical record does not contain any known account


bass in this trio. Taylor was already 59 when this album came out. He'd never see 61, dying in December of 1974. He wrote his epitaph when he said "I'll be dead years from now and people will say 'He couldn't play worth a shit, but damn could he make it sound good!"

On his first album for RSO, Freddie King teamed up with his new label mate and #1 fan Eric Clapton on the duet "Sugar Sweet". That, and the airbrushed cover by artist Peter Palombi, are probably what Burglar is best known for. It's a bit of a surprisingly funky mixed bag, especially for those seeking pure blues. I like the deep track "My Credit Didn't Go Through" but maybe because I've recently tried to re financewhere he was never found.The explosion also seriously injured Yamaki, who had been working inside.The midget was unusable, and was abandoned. The mother sub turned back quickly to Truk, unloaded the wounded Yamaki, and collected a jubilant Ban and Ashibe together with their intact submarine.The I-24 then raced south to catch up with the rest of the fleet.

Meanwhile, the skirmish with the _Wellen_ stirred the Australian defences into action. Rear Admiral Muirhead-Gould, Naval Officer in Command, Sydney, ordered all merchant ships to remain in Sydney and Newcastle harbours. He then mounted an air and sea search for the aggressive submarine. After 24 hours, with no trace of the sub, he reopened the harbours.The search continued for several days.The Allied ships and planes found nothing.

It was now time for


for the midget commanders to worry about speed.Their torpedoes had only one setting: flat-out at 44 knots. Depth of running would determine which ships could be attacked and which could not.A torpedo set to run deep would pass harmlessly under a small warship but do maximum damage to a battleship or an aircraft carrier. Matsuo and Chuman set their torpedoes to run at 6 metres below the surface—a fairly deep setting even for a battleship or heavy cruiser—while Ban chose the slightly more conservative 5 metres.

The next question was deflection. The Type 97 Special torpedo carried by the Japanese midgets could be set to turn after firing by up to 60 degrees to the left or right, with the deflection angle marked in 5-degree intervals. A submarine commanderbe relieved at midnight. When his relief failed to materialise, he went to look for him aboard _Kuttabul._ As a way of apologising for failing to turn up for duty on time, the chastened relief offered Roberts his bunk on the more pleasant upper deck, instead of Roberts' usual bunk on the lower deck. Roberts accepted. And lived.

Able Seaman Charlie Brown had also been on sentry duty. He had heard the gunfire and explosions on the harbour, and wondered what was happening. He went off duty at midnight and by 12.10 was asleep in his bunk on the lower deck near the bow. His next memory is of a gigantic orange ball of fire, and of being blasted between a row of wash basins through the ship's side


boom, boom, boom, then a huge, loud explosion.

We were very frightened because it just wasn't natural to have all that light. The whole sky was lit up with searchlights. There seemed to be a lot of people. They just came from nowhere. Everyone was running all over the streets, not knowing what was going on.

Rahel Cohen, a 23-year-old secretary serving in the Women's Auxiliary Air Force, had come to Sydney from Wagga Wagga on leave.At 12.15 am she caught the last ferry from Circular Quay to Athol Wharf near her parents' home in Mosman. There were only four people on board— Rahel, an army officer Captain Ross Smith, the ferry captain and the ferry's engineer.

The ferry captain decided to take a slightly longer route this night. The Atholto the suburb of Mosman had fled.That night Rahel Cohen walked home, escorted in the darkness by the gallant Captain Smith.

Muirhead-Gould left the boom net in his barge and went straight to his headquarters on Garden Island. Clearly his first job was to find out what had happened.This will not have taken long. By now there were plenty of people who knew it was a torpedo attack.

Jimmy Mecklenberg arrived on Garden Island in the _Chicago_ 's Captain's gig at about the same time as Muirhead-Gould. His account of his encounter with Muirhead-Gould is a masterpiece of tact. 'The Admiral was well aware that there were submarines in the harbour,' Mecklenberg recalled. 'He suggested that I should tell my commanding officer to take the US forces to sea.'There is


on top of the other, were partly open with the noses of the torpedoes protruding. The top one was out about three feet and the lower about 18 inches.

Soon I felt my lines tighten and heard Roy Cooté say over the phone: 'I can hear the motor running and will be getting out of this as soon as this buoy rope is made fast.'

Roy Cooté's dive log is, as usual, the soul of brevity:'Dived off Taylor Bay for Jap sub. Found it still alive and moving.'

There is one addendum to this story which is worth recording, though it is not to be treated as cast-iron fact. There is a standard procedure for divers sent down to find and recover stricken submarines.They tap on the hull. If any ofapproach for several reasons:

This data format is probably used internally only, so it doesn't matter whether it is pretty or not, as long as it is machine readable.
It is easily extensible. Want a Z-Coordinate? Well, add another element. This is possible without breaking existing functionality! This means that a version of your application that requires a Z-Coordinate can still read an XML file that does not contain it and assume Z as 0. A version of your application that can not handle a Z-Coordinate will simply ignore it.
It is easily validatable. You can assume every coordinate to contain a float value, which can be validated using standard means like XSD. The other formats require more knowledge about the content of each element, which may not be included in


the sear. Nor is the tip of the sear arm cylindrical, which would have a similar effect. Rather, the "hole" is a depression in the wheel (like a small crater), and the sear has a rounded end: the wheel is locked by reason of lateral force on the shaft of the wheel rather than vertical force on the sear.

As soon as the wheel is released by the sear, the longer arm of the mainspring pulls the chain engaged in it. The other end of the chain being fixed to the cam on the wheel shaft, the latter rotates at high speed, whilst the rotating cam pushes forward the arm to which the pan cover is attached, thus causing the pan cover to slide forward towards the muzzle ofDetection of Campylobacter jejuni/C.coli infection in patients with Guillain-Barré syndrome by serology and culture.
Serum samples from 43 cases of Guillain-Barré Syndrome (GBS), 32 non-GBS neurology patients, and 35 healthy persons from a medical institute in Kerala, India, were tested for antibody levels against a Campylobacter jejuni strain Penner serotype 0:19 by agglutination and ELISA. Twenty-six percent of samples from GBS cases showed high antibody levels in all assays. Of 8 stool samples of new GBS cases examined by culture, 38% were positive for C. jejuni/C. col1. The results suggest that at least a quarter of GBS cases studied were associated with Campylobacter infection.


safe and accurate?

When the heart’s blood vessels become clogged with cholesterol, it sets the stage for a heart attack, and this year, nearly half a million Americans will die from heart disease. What's more, due in part to rising obesity rates and the popularity of fast food, heart-attack victims are getting younger and younger. It should come as no surprise, then, that high cholesterol is increasingly being referred to as a “silent killer.”

Stay Home or Leave It to the Lab?An estimated 105.2 million American adults have total blood cholesterol values of 200 mg/dL and higher, and of these, about 36.6 million have levels of 240 or above. In adults, total cholesterol levels of 240 mg/dL or higher are considered high risk, while levels from 200 to 239 mg/dLor if you feel your date getting into it. This may lead to being invited inside, but don't count on it. She will also really like it if you keep it locked on her cheek for about 3 seconds not 3 minutes

If you want to be extra cute you could even kiss her hand or forehead, but be wary of the forehead kiss as some girls find it patronising or granddad like. When you're walking away, give a little glance back - chances are she'll be watching you go. Add comments such as "Tonight was amazing" or "I hope we can do this again sometime (And show her that you MEAN it" to make her feel special. If you feel her trying to move away or say 'No',


a kid too. Buy them toys and candy. * But teach them not to expect gifts all the time. They should know the best gift is your time, attention and love. * If you buy them a lot of candy, be sure to encourage good dental hygiene. Have sleep overs. * Let them stay up late. * Eat junk food for dinner. * Do fun interactive stuff together like crafts or games. Take them to parks, play grounds, and other fun places. When they get older, listen to them when they have a problem. Give advice especially when needed.

* Your money may run out if the child asks for too much, so don’t be a pushover. * If the child is an infant, get ready to be awakeMaybe start eating healthier so you will feel your best when you wear that bikini.Get a tan. Be careful, you don't want to end up looking like a carrot. Just buy a nice spray tan from a local drugstore, but never apply it with your hands. Rent a beach house. There's nothing better than relaxing at the beach watching the ocean. Work on your confidence. There's nothing better than someone walking with her head straight up feeling her best. Plus, guys will stop to check you out.Make lots of plans ex. invite over friends, get a week to go on vacation, make plans with your boyfriend or husband

Plan out everything you will do each day.If you live in a tourist city, then you have a big advantage to


disease. Kidney Disease (Nephropathy)/Kidney Transplantation: Diabetes can cause kidney damage and, if the kidneys lose the ability to filter out waste products, a condition known as nephropathy. To prevent kidney problems, the National Institutes of Health urges patients to talk to their doctors about their target blood glucose and blood pressure levels and to monitor those levels closely. Eye Complications: Diabetes can result in eye problems, which could eventually lead to blindness. Since people with diabetes have a higher risk of blindness than people without diabetes, early detection and treatment of eye problems can be sight-saving. Diabetic Neuropathy and Nerve Damage: Neuropathy is one of the most common complications of diabetes, and it means the nerves that run throughout the body connecting the spinal cord to muscles, skin,a desert shrub found in the southwestern United States and Mexico. Research hasn't shown that the herb effectively treats cancer, and it can lead to irreversible liver failure.

PC-SPES. This mixture contains eight herbs that have been used for hundreds of years in traditional Chinese medicine to treat prostate issues and other health problems. Some studies show it may reduce cancer growth, but it can also cause side effects. It was sold as a dietary supplement, but is no longer being manufactured because some batches were found to contain prescription drug ingredients. While the individual herbs are still available, the PC-SPES mixture has not been reintroduced because further studies are needed to determine whether it's safe.

Shark cartilage. Shark cartilage contains a protein that has some ability to inhibit the


formation of new blood vessels within tumors in sharks. Shark cartilage therapy is based on the theory that capsules containing shark cartilage will do the same in humans — stop and shrink cancerous tumors. However, these benefits haven't been shown in humans.

Talk with your doctor firstBecause it's not always easy to tell which products may be unsafe, interact negatively with other medications or affect your overall cancer treatment, it's best to talk with your doctor before you take any dietary or herbal product.

Okay, girls! Boys are not the most important things in our lives -here's how to enjoy life without a boyfriend.

Concentrate on your friends, family and school work for a bit. You're at school for a few years of your life and then you're working for aboutyour mind free of men, get some new hobbies and try new things! You never know, you could find something you really enjoy doing. Consider volunteer work at your church or local hospital. Seeing others with harder circumstances than having no boyfriend may help you appreciate the good things in your life.

* Times when you are between men can be some of the most rewarding and growth-oriented times of your life. Enjoy this time to find out about yourself, do as you please, go where you want when you feel like it without checking with someone first, and sleep whenever you want to! * Try a hobby - photography with a digital camera is fun and doesn't cost a lot to get started. A nice Nikon Coolpix or


your life with. * Consider having a girlfriend instead. Maybe the boyfriends aren't working out for a reason. ;)

* Don't be cold with men. Your male friends don't deserve to be treated coldly because you are bitter about not having a boyfriend. Its not fair to make every man you interact with the punching bag for frustrations you have with your own inadequacies. Misandry never helped anyone lead a happy life. * If you are too desperate, needy or bitter, you'd better memorize this, because you will be living without a boyfriend for the biggest part of your life.

Once you receive a diagnosis of prostate cancer or treatment for this disease, you may experience a range of feelings — including disbelief, fear, anger, anxiety, emptiness and depression. YouCandida sp. 99-125 lipase-catalyzed synthesis of ergosterol linolenate and its characterization.
As a major sterol in edible mushroom, ergosterol has gained much attention owing to its potential bioactivities. However, ergosterol has a high melting point, poor oil solubility and stability, which restrict its scope of application. In this study, an ergosterol ester of α-linolenic acid was successfully and efficiently prepared using Candida sp. 99-125 lipase as a biocatalyst. The desired product was confirmed to be ergosterol linolenate using MS, FT-IR, and NMR analyses. Using Candida sp. 99-125 lipase, the product conversion exceeded 92% in 12 h under the following optimized parameters: 75 mmol/L ergosterol, 40 g/L lipase, 1:1.25 ergosterol-to-α-linolenic acid molar ratio, and 45 °C. The results confirmed that Candida sp. 99-125 lipase has good reusability and stability and


(ie. JOHN HENRY DOE not John Henry Doe). Look at every official document you get, your name is in ALL CAPS. When you sign a document without specifying “Authorized Representative” you become surety for the “legal fiction” and are liable for whatever was written on the document.

www.scribd.com

Tags: BankingThe present invention relates generally to bulk acoustic wave resonators and filters and, more particularly, to the tuning of such resonators and filters.
It is known that a bulk acoustic-wave (BAW) device is, in general, comprised of a piezoelectric layer sandwiched between two electronically conductive layers that serve as electrodes. When a radio frequency (RF) signal is applied across the device, it produces a mechanical wave in the piezoelectric layer. The fundamental resonance occurs when the wavelength of the mechanical wave is about twice the thickness of the piezoelectric layer. Although the resonant frequency of a BAW device also depends on other factors, the thickness of the piezoelectric layer is the predominant factor in determining the resonant frequency. As the thickness of the piezoelectric layer is reduced, the resonance


wave generating and controlling layers formed on the substrate, wherein the acoustic wave generating and controlling layers include a piezoelectric layer formed between a first electrode and a second electrode for generating piezoelectrically excited acoustic signals, wherein the first electrode has a frame-like structure at an edge portion of the first electrode for reducing spurious resonance components in the acoustic waves, and the frame-like structure surrounds a center zone having a surface area, and wherein the device has a resonance frequency which can be down-shifted by modifying the first electrode. The method comprises the step of providing a tuning layer on top of the first electrode for modifying the first electrode such that the tuning layer covers at least the surface area of the center zone for reducingspurious resonance resulting from the tuning layer.
Alternatively, the tuning layer also covers at least part of the frame-like structure.
Preferably, the tuning layer substantially covers the entire frame-like structure.
According to the second aspect of the prevent invention, a bulk acoustic wave device comprising a substrate and a plurality of acoustic wave generating and controlling layers formed on the substrate, wherein the acoustic wave generating and controlling layers include a piezoelectric layer formed between a first electrode and a second electrode for generating piezoelectrically excited acoustic signals, wherein the first electrode has a frame-like structure at an edge portion of the first electrode for reducing spurious resonance components in the acoustic signals and the frame-like structure surrounds a center zone having a surface area, and wherein the device has a


such as, for example, when packaging six beverage bottles, the handle openings may take the form of finger holes spaced apart along the length of the carrier. If the load is relatively great, as in a carrier for packaging twelve or more beverage bottles, the handle openings are typically elongated hand openings spaced apart across the width of the carrier. When the carrier is lifted, the strap-like portion of the top panel between the hand openings is subjected to a great deal of stress and can be in danger of tearing if it is not of suitable strength.
Various designs have been proposed to strengthen the handle area, primarily by making it of greater thickness than the rest of the top panel. One way of accomplishing this has beentitles are up for grabs this day with the rider and age group series classes concluding with the NZ National Horse Derby Championship. A hit with spectators in its first occurrence at Nationals last year, it is bound to be even better again. It will be followed by an entertaining charity event to round out a fun-filled Saturday evening.

The final day of competition on Sunday will comprise of two round competitions to decide the winners of the Championship classes. All competitors will go through to the final day of competition, where the top ten will be rewarded with increased prize money.

Premier level points are up for grabs in all National Series Classes including the Dunstan Horsefeeds & Equifibre NZ National Horse Grand Prix Championship. In addition to the


 (January 8, 2001)

Before BARKETT and WILSON, Circuit Judges, and DOWD*, District Judge.

BARKETT, Circuit Judge:

       *
        Honorable David D. Dowd, U.S. District Judge for the Northern District of Ohio, sitting
by designation.
       Auto Cargo, Inc. (“Auto Cargo”) appeals from summary judgment in favor

of Miami Dade County (“Dade County”) in this action brought on behalf of a class

of all persons and entities required to pay to Dade County $7.50 for every used,

self-propelled vehicle exported through the U.S. Customs vehicle inspection

facility at the Port of Miami (the “Port”). The question presented is whether the

required payment is prohibited by the Import-Export Clause of the U.S.

Constitution. We affirm, finding that it does not violatedown a direct state tax on jet fuel sold for

export as violative of the Import-Export Clause). In Washington Stevedoring, the

Supreme Court made clear that the Michelin analysis applies to cases involving

exports as well as imports. See 435 U.S. at 753-58 (finding that a state tax on

stevedoring activities did not disturb the three policies protected by the Import-

Export Clause). Accordingly, we analyze the inspection fee to determine whether

its effects undermine the three policy concerns identified by the Michelin Court.

      First, the inspection fee can have no possible effect on foreign commercial

relations, as it applies only to business conducted at the Port and imposes no

burdens on foreign businesses. See Washington Stevedoring, 435 U.S. at 754

(finding no effect on commercial regulation where challenged tax affects only

business


want is not a new Middle East, but to be rid of them and put a tall fence between us and them.... to maintain a Jewish majority in the Land of Israel."

Days earlier he said that the left "makes the same mistake again when it negotiates the division of Jerusalem... The Palestinians must be brought to an understanding that Jerusalem will always remain under Israeli sovereignty and that there is no point for them in opening negotiations about Jerusalem." He added that Israel will not allow a "right of return" for Palestinian refugees. "We need to be clear about Jerusalem as well and then they will understand that this is our solid position."

"We have no existence without Jerusalem," Lapid added. "The Tower of David is important for Israel's

Ever since the release of The Force Awakens, Star Wars fans have been clamoring for more Poe Dameron. Thanks to Marvel, they’ll get it.

Star Wars: Poe Dameron, a new ongoing series starring the Resistance’s charismatic (and best) pilot, launches this Wednesday, April 6, with issue #1. Written by Charles Soule and illustrated by Phil Noto, the story begins with Poe and his X-wing squadron investigating sites of historical importance to the Force…and running into the First Order.

To mark the release of this major addition to Star Wars canon, Phil Noto has provided StarWars.com with exclusive commentary on the first five pages from the upcoming debut issue, offering insight on how he approached pages and panels. Lock S-foils in attack position and enjoy.

Phil Noto: Starting off with a nice


a sense of place and convey the feeling that he was flying from one chamber to another.

Phil Noto: I wanted to get across the feeling that this was a very large cavern that he was flying through, but keeping the fighter at a reasonable size so there weren’t just word balloons coming out of a dot on the page. The perspective and foreground stalactites helped convey this.

Phil Noto: Explosions are always fun and add action to the page. Originally, the cavern hologram was just going to be a video screen image but Charles had the idea of making it a floating 3D element. I’m pretty happy with the Oscar Isaac likenesses on this page as he’s incredibly tricky to draw. If you get his features just right, he’sthe place of service, until January 1952; that although she still continues to operate the hardware *598 store which has been operated at that address for the past 14 years, she and her husband moved their living quarters from the store premises in January 1952 to 130 Keer Avenue, Newark. She and her husband lived there until July 1953, but, says she, "in that month we separated * * * my husband left the home. As a result of this action, I have lost all interest in my husband, and neither care nor know where he is residing."
How the defendant learned of the suit does not appear, nor is it explained why this supposedly angered wife supplied the only affidavit in defendant's behalf.
At common law, objection to the


manner of the service of a writ, based on matters dehors the record, was made by a plea in abatement. Nye v. Liscombe, 21 Pick. 263 (Mass. Sup. Jud. Ct., 1838); Bishop v. Vose, 27 Conn. 1 (Conn. Sup. Ct. of Err., 1858); 71 C.J.S., Pleading, § 133.
Although we abolished the form known as the plea in abatement long ago, much of the relief which that plea provided is still essential to justice and to orderly and logical pleading. Hence we provide that that relief be obtained by motion. However, those fundamental principles which controlled, and the incidents that arose from, the old plea in abatement still apply insofar as they advance justice and are consistent with our rules. Cf. Commercial Credit Corp. v. Boyko, 103 N.J.L. 620,States.”

Take Our Jobs will be featured on the Colbert Report on July 8. We’re glad Colbert will be doing his part to help the unemployed of America find some honest work — and get a discussion about immigration reform going. Any attempts to reform our food system have to include ending the exploitation of undocumented, unprotected workers.


units digit of y?
2
Let k = 2 - 1. Let f = k + 0. What is the units digit of (1 + -1)/(-1) + f?
1
Suppose 0 = 5*j - 3*j - 2. Suppose 0 = -t - j + 32. What is the units digit of t?
1
Let y(z) = z**3 - 8*z**2 - 6*z - 7. What is the tens digit of y(9)?
2
Let d(h) = 2*h - 3 + 0*h - 5. Let l be d(6). Suppose 0*t = l*t - 2*f - 30, -2*f = t. What is the units digit of t?
6
Let o(t) = 25*t**2 - 11*t - 14. What is the hundreds digit of o(-3)?
2
What is the units digit of 3 + -5 - -1 - -2?
1
Let v(g) = -g**3 + 14*g**2 + 17*gdigit of 3 + 2 + 2/v?
6
Suppose -4*c = 4*p - 13 - 7, -14 = -2*p - 4*c. Suppose -p*k = 3*u - 6*k - 63, -5*u + 90 = -2*k. What is the tens digit of u?
1
Let o(x) be the second derivative of -5/2*x**2 - 1/3*x**3 + 0 + 3*x. What is the tens digit of o(-8)?
1
What is the units digit of (5 + 7)*2/3?
8
Suppose 3*c + 13 = -0*x - 2*x, -4*x - 27 = 5*c. Let z = x + 20. What is the tens digit of z?
1
Suppose 0*h - 140 = -4*h. What is the units digit of h?
5
Suppose -3*x = -10 - 5. Let d(f) = 2*f**2 - 5*f - 1. What is the tens digit of d(x)?
2
Suppose 3*l = 13 -


4. Suppose -l*i = 2*i - 10. What is the tens digit of i/12 + 295/30?
1
Let h be (-3)/(-2 + 33/18). Let p be 16/9 - (-4)/h. What is the units digit of -3 + p + (8 - 1)?
6
What is the tens digit of (4 - 0)*(2 - (-86)/8)?
5
Suppose u - 13 = -0. Suppose -u = -f - 0*f. Let x = 22 - f. What is the units digit of x?
9
Let n(y) = -13*y - 49. What is the units digit of n(-16)?
9
What is the units digit of (-3)/((-12)/164) - -2?
3
Suppose 2*h + h - 30 = -4*l, -2 = l - 4*h. Let i = l + -3. What is the units digit of i?
3
Suppose 4 - 11 = b. Let j = bt(-6). Suppose -19*l + 175 = -14*l. Suppose j*r - 2*c - 27 = 0, 2*r + 2*r - l = 3*c. What is the tens digit of r?
1
Suppose -5*p - 390 = -2*u, -2*u - 5*p + 476 = 106. What is the units digit of u?
0
Suppose -4*g + 579 = 35. What is the tens digit of g?
3
Let c(t) = t**3 - 4*t**2 - 2*t + 2. Let h(p) = -p - 2. Let n be h(-4). Suppose n*f - 6 = 4. What is the tens digit of c(f)?
1
Let n(d) = -d**2 + 9*d - 4. Let k be n(6). What is the units digit of (-4)/(-14) + 24/k?
2
Let l = 0 - -2. Suppose f + 2 = 3*k + 19, -26 = -l*f


void begin() {
    }

    public void end() {
    }

    public String getType() {
        return type;
    }

    public void setType(String type) {
        this.type = type;
    }

    public TraceNode parent() {
        return parent;
    }

    public void setParent(TraceNode parent) {
        this.parent = parent;
    }

    public List<TraceNode> getChildren() {
        return children;
    }
}
downloaded GSE87411 microarray dataset from NCBI Gene Expression Omnibus (GEO) database (<https://www.ncbi.nlm.nih.gov/geo/>). The microarray contained 109 pairs of samples from patients in Z1031 trial, including untreated samples and post-treated samples with neoadjuvant aromatase inhibitor (AI) therapy. Z1031 trial is a randomized neoadjuvant phase II trial in postmenopausal women with clinical stage II/III ER-positive breast cancer. The trial was designed to determine which aromatase inhibitor (Anastrozole, Letrozole or Exemestane) or subset of agents should be recommended for future evaluation against chemotherapy in neoadjuvant setting based on differences in clinical response rates after 16 weeks of treatment^[@CR8],[@CR10],[@CR11]^. After 16 weeks of therapy, no significant difference was found among three endocrine agents in terms of Ki67 suppression. Furthermore, the efficacy of chemotherapy was lower than expected in ER-positive cancer exhibiting AI-resistance^[@CR8],[@CR10],[@CR11]^.


expression of RAD51, which was an oncogenic marker, was related to a poor prognostic outcome of breast cancer including shorter survival of patients and AI-resistance in neoadjuvant setting.

Methylation of BRCA2 decreased its inhibitory effects on RAD51 {#Sec13}
--------------------------------------------------------------

To figure out the mechanisms underlying RAD51 and AI-resistance, Molecular INTeraction Database was utilized to discover protein-protein interactions between RAD51 and other proteins. It showed that only BRCA2 had direct interaction with RAD51 and *vice versa*. Based on the analysis from Molecular INTeraction Database, the direct protein-protein interaction between RAD51 and BRCA2 was verified by pull down assays. It is reported that BRCA2 directly binds to RAD51 through its BRC repeats and regulates both the intracellular localization and the DNA-binding ability of RAD51. BRCA2 plays multiple roles in the maintenance of genomeshown in Fig. [6B](#Fig6){ref-type="fig"}. The results indicated that an increased expression of BRCA2 and a decreased expression of RAD51 were detected in ER-positive breast cancer samples with low-methylated BRCA2 (*P* = 0.032, *P* = 0.007, separately). All above results demonstrated that the methylation of BRCA2 led to its diminished expression, which caused incomplete suppression of RAD51 thus elevating the expression of RAD51, and hence an unfavorable outcome of breast cancer, especially ER-positive breast cancer.Figure 6The methylation of BRCA2 was associated with aberrant expression of RAD51. (**A**) Expression of BRCA2 was negatively regulated by the methylation of BRCA2 in breast cancer (*P* \< 0.05). Highly expressed RAD51 was detected in breast cancer samples with high-methylated BRCA2 by analyzing the TCGA data (*P* \< 0.05). (**B**) In ER-positive breast cancer, decreased expression of BRCA2 and increased expression of RAD51


was progressively increasing in luminal, Her2-positive and triple-negative breast cancer tissues comparing with normal breast tissues. To explore the role of RAD51 in the predication of AI-resistance, the correlation between the expression of RAD51 and MKI67 was further investigated. A positive relationship was discovered between the expression of RAD51 and MKI67. Moreover, compared with MKI67, RAD51 was found to be a better indicator to distinguish AI-resistant breast cancer from all AI-treated breast cancer in neoadjuvant settings. Our study provided evidences that high expression of RAD51 predicted adverse outcomes, including AI-resistance and shorter survival, for patient affected by breast cancer. Firstly, overexpression of RAD51 was found in breast cancer compared to normal breast tissue, which facilitated the clinical application by qPCR detection. Secondly, based on microarray data of Z1031    [Unpublished]
                                 ____________

Before GRUENDER, KELLY, and GRASZ, Circuit Judges.
                          ____________

PER CURIAM.

      This case is before us on remand from the Supreme Court of the United States.
See Cox v. United States, 589 U.S. ---,140 S. Ct. 396 (2019) (mem.), vacating 766 F.
App’x 423 (8th Cir. 2019) (per curiam). The Supreme Court granted certiorari,
vacated our judgment, and remanded the matter for reconsideration in light of


if (i % 3 === 0 && i % 4 === 0) {
    console.log('Play Ball');
  } else {
    console.log(i);
  }
}

A:

You just need to move thisi % 3 === 0 && i % 4 === 0 condition to the top:

for (var i = 1; i <= 100; i++) {

  if (i % 3 === 0 && i % 4 === 0) {
    console.log('Play Ball');
  } else if (i % 3 === 0) {
    console.log('Play');
  } else if (i % 4 === 0) {
    console.log('Ball');
  } else  {
    console.log(i);
  }
}

virtual machine with MSDOS on it, but you'd have to find a way to install MSDOS 6.22 on the virtual machine. At Microsoft's support site, they have links to a bootable ISO file for MSDOS 6.22. I still have the original floppies and started with those on an old system that has a floppy drive. It's a bit awkward to import / export files to / from the virtual machine.
This is the config.sys that I use that seems to work with Win 7 virtual machine. I had to increase buffers, stacks, and files to avoid a stack overflow problem with this setup.
dos=high,umb
buffers=40,0
files=60
lastdrive=e
shell=c:\command.com c:\ /e:1024 /p
stacks=64,512
switches=/f
device=c:\dos\himem.sys /numhandles:64 /testmem:off
device:c:\dos\emm683.exe ram i=b100-b7ff i=c600-c7ff i=cc00-cfff i=e600-efff frame=d000 a=32 d=128 notr
devicehigh=c:vmadd\cdrom.sys /d:mscd001

This is the autoexec.bat that I use (smartdrv is a bit


it('tests Title component creation', () => {
        const l = {
            name: 'layer00',
            title: 'Layer',
            visibility: true,
            storeIndex: 9,
            type: 'wms',
            url: 'fakeurl'
        };
        const comp = ReactDOM.render(<Title node={l} />, document.getElementById("container"));

        const domNode =title: {
                'default': 'Layer',
                'it-IT': 'Livello'
            },
            visibility: true,
            storeIndex: 9,
            type: 'wms',
            url: 'fakeurl'
        };
        const comp = ReactDOM.render(<Title node={l} currentLocale="it-IT"/>, document.getElementById("container"));


constructed Foo object.
  Foo foo_zero;

  // It is not clear to me which constructor
  // should be called by the following statement.
  Foo foo_test = { foo_zero };

  // Return exit code.
  // Clang 6.0.0 returns 0 (i.e. implicit copy constructor was called for 'foo_test').
  // GCC 8.2 returns 2 (i.e. initializer list constructor was called for 'foo_test').
  return foo_test.val;
}

My questions are the following:

What should be the return value of my example program (Clang and GCC do not seem to agree)?
Is there a way to have the initializer list constructor of my example program called with the syntax used that works with Clang and GCC?

A:

Clang implemented DR 1467 (brace-initializing a T from a T behaves as if you didn't useQ:

OS X Terminal - Find Text in Files Beginning With Variable

I need to search through a folder of files and copy all text that begins with a variable.
So for example:
Files A.txt,B.txt,C.txt, and D.txt contain the strings "Hello1", "Hello2", "Hello3", and "Hello4" respectively. I need to be able to search for all words that begin with "Hello" and output the result.
In this particular case A.txt,B.txt,C.txt, and D.txt would be searched and the output would be
Hello1
Hello2
Hello3
Hello4

I've looked around and found the following which allows me to export all files containing the text, however I'm not sure how or if this can be adapted for what I need.
grep -l Hello *.txt

A:

You probably want grep -ohw 'Hello[0-9]*' *.txt.

-o only outputs the matching part of the line
-h makes grep suppress filename output
-w


between the impacting ball and the container boundaries. Nelson *et al.* found that “the presence of sidewall causes less penetration and an effective repulsion” [@refDurian2008; @refSequin08].

In this paper, we present experiments in which the size of the container has been systematically reduced. We did this by (i) decreasing the depth of the sand bed (section \[shallow\_bed\]) and (ii) reducing the container diameter to only a few ball diameters (section \[boundaries\]). We explore how these confinements change the behavior of the ball inside the bed, the void collapse, the resulting jet height and shape, and the presence of a granular eruption, which was only observed in part of the parameter space covered in this study. All of the observed phenomena are explained within the context of a simple hydrostatic collapse model [@refLohsePRL04] togetherturn to the description of the experimental setup, which is sketched in Fig. \[setup\]. It consists of a container with a height of $1$ m and a square cross section of $14\,\times\,14$ cm$^2$, which is filled with sand grains, nonspherical and slightly polydisperse in size (between $20$ and $60$ $\mu$m); the density of the granular medium is $2.21$ g/cm$^3$ and its angle of repose $26^\circ$. As described in [@refCaballeroPRL07], before each experiment, the sand is fluidized by blowing pressurized dry air through a sintered plate at the container bottom. After slowly turning off the air flow, the bed reproducibly settles into a static, loose, weakened state (volume fraction $41$ $\%$). The airtight system can be slowly evacuated to perform experiments at lower ambient pressures $p$ (the pump speed is low enough not to irreversibly alter


side walls\[boundaries\]
=========================================

![image](figure07.eps){width="0.85\linewidth"}

In the previous section, we discussed the influence of the bottom of the cavity on the process of object penetration and jet formation and found that, if the sand depth is fixed at $30$ cm, there is no effect of the bottom on the jet formation process. Fixing this bed depth, we now turn to study the effects of the side walls of the container on the complete series of events leading to the jet. For this, some cylinders of different diameters $D$ are placed inside the sand during the fluidization process: we choose $D = 4.2$ cm, $6$ cm, $8.5$ cm, $10$ cm and $12.5$ cm. In this way we change the aspect ratio $D/d$ from $2.6$ to $7.8$.

Ball trajectory
---------------

The first thing that happens upon impact of the ball onto the surface$t_c$, the rise time of the bubble has been estimated as that of similarly sized bubble in a liquid experiencing Stokes drag, assuming that it rises in a straight path with its terminal velocity immediately, i.e., from the balance $\phi\rho_g V_{\rm bubble} g \propto \eta V_{\rm bubble}^{1/3} v_{\rm rise}$ (with the packing fraction $\phi$ and the dynamic viscosity $\eta$ assumed to be constant) we have $v_{\rm rise} \propto V_{\rm bubble}^{2/3}g$ with $V_{\rm bubble} \propto (z(t_c) - z_c)d^2$. Now, we estimating the initial position of the top of the bubble as $z_{\rm f} - (z(t_c)-z_c)$. This leads to $t_1 = (z_{\rm f} + z_c - z(t_c))/v_{\rm rise} \propto (z_{\rm f} + z_c - z(t_c))(z(t_c) - z_c)^{-2/3}d^{-4/3}g^{-1}$. The proportionality constant was fitted to give the correct large depth behavior.

Regarding the


but it goes on and on.

That seems to have nothing to do with my book. No one would detect Tarantino as an influence while reading The Buried Giant, but I thought it was such a great way to deal with an explosion of violence. You actually don’t have to spend a lot of energy on the violence itself. It’s the lead up, the tension. So, yes, I’m quite open to reading or hearing or seeing anything at that point in the process.

Chang: What was behind the decision in setting The Buried Giant in a mythical, medieval England? Did you know this would surprise people the way it has?

Ishiguro: Often the setting comes quite late in the process. I usually have the whole story, the whole idea, and then<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0.1 Transitional//EN">

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Boost.MultiIndex Sequenced indices reference

Hashed indices

Boost.MultiIndex reference

Random access indices

Contents

Header
    "boost/multi_index/sequenced_index_fwd.hpp" synopsis

Header
    "boost/multi_index/sequenced_index.hpp" synopsis

sequenced index specifier

Sequenced indices

Complexity signature


succeeded, false
otherwise.

Complexity: O(M(n)).

Exception safety: Basic. If an exception is thrown by some
user-provided operation (including mod), then
the element pointed to by position is erased.

template<typename Modifier,typename Rollback>

bool modify(iterator position,Modifier mod,Rollback back);

Requires: mod and back are unary function
objects accepting arguments of type
value_type&. position is a valid dereferenceable
iterator of the index.
The execution of mod(e), where e is the element
pointed to by position, does not invoke any operation of the
multi_index_container after e is directly modified
or, before modification, if the operation would invalidate position.
back(e) does not invoke any operation of the
multi_index_container.

Effects: Calls mod(e) where e is the element
pointed to by position and tries to rearrange *position into
all the indices of the multi_index_container. Rearrangement on sequenced
indices does not change the position of the element with respect to the index;
rearrangement on other indices may or mightnot succeed.
If the rearrangement fails, back(e) is invoked: if the resulting value
of e is consistent with its original position and constraints in all
indices, the element is kept, otherwise it is erased.

Postconditions: Validity of position is preserved except if
the element is erased under the conditions described below.

Returns: true if the operation succeeded, false
otherwise.

Complexity: O(M(n)).

Exception safety: Strong, except if mod or back throw an
exception or back(e) fails to properly restore the element or there is
a throwing user-provided operation after invoking back(e), in which cases
the modified element is erased. If back
throws inside the handling code executing after some other user-provided
operation has thrown, it is the exception generated by back that
is rethrown.

List operations

Sequenced indices provide the full set of list operations found in
std::list; the semantics of these member functions, however,
differ from


[first,last).

Effects: The range of elements [first,last)
is repositioned just before position.

Postconditions: No iterator or reference is invalidated.

Complexity: Constant.

Exception safety: nothrow.

template<typename InputIterator> void rearrange(InputIterator first);

Requires: The range [first,
std::advance(first,n)),
where n is the size of the index, is a
free view of the index.

Effects: The elements are rearranged so as to match the
order of the previously described view.

Postconditions: No iterator or reference is invalidated.

Complexity: O(n).

Exception safety: Basic.

Serialization

Indices cannot be serialized on their own, but only as part of the
multi_index_container into which they are embedded. In describing
the additional preconditions and guarantees associated to sequenced indices
with respect to serialization of their embedding containers, we
use the concepts defined in the multi_index_container
serialization section.

Operation: saving of a multi_index_container m to an
output archive (XML archive) ar.

Requires: No additional requirements to those imposed by the container.

Operation:sorry." "Down on all fours." " Lick it up." " Excuse me?" "Why don't we talk in private." "Yeah." "Let's." "What about my boot?" "Sorry to interrupt your campaigning, but we're looking into the murder of Roxanne Greer." " Who?" " You knew her as Sweet Lady Pain." "I don't think I'm familiar with..." "[CHUCKLES]" "I ate her brain and had a vision of you wearing a gimp mask." "You told Lady Pain you were a bed-wetting, thumb-sucking liar and unworthy of your success." "Think that'll fit on a bumper sticker?" "That's just two consenting adults..." "Don't apologize." "It's pathetic." "So what happened?" "Did you discover the hidden camera, lose your cool?" "There was a hidden camera?" "Wait!" "Are you asking me if I murdered Sweet Lady..." "Miss


Greer?" "She was murdered on the evening of the 25th." "Do you remember your whereabouts that evening?" "Ah..." "I was at a campaign fundraiser." "So there must have been dozens of donors present that can confirm it." "Why don't you just give me a few?" "[EXHALES]" "You want me to do nine different sketches?" "Did you see the starting lineup of a baseball team murder someone?" "I'm assisting Detective Babineaux with a murder investigation." "An anonymous witness sent me Snapchats with photos they took of possible suspects." "As soon as I open the images, they disappear." "You could've saved us both a lot of time if you'd just screen-grabbed the images." "When I want your advice, I'll beat it out of you." "Now be a good little sketchsay you visited her dungeon on a regular basis?" "I wouldn't say anything that in any way would confirm or deny visiting anywhere." "I will say that the definition of "regular basis"" "varies from person to person." "Your "regular basis" could be my "sporadic."" "Are there any other questions you'd like me to expertly evade?" "Yes." "Can you order a Catholic schoolboy's uniform in a 44-tall or do you have to have that specially made?" "You have very specific ideas regarding my alleged connection to the victim." "Would it be accurate to say that there's an existing record of Ms. Pain's sessions?" "Mmm, we can neither confirm or deny that." "Some of Roxanne's clients mentioned she had a problem with an unwanted voyeur." "Know anything about that?" "Assuming


radio." "Caleb Tuttle worked for us." "The police said they found tubes like these in his refrigerator." "Tubes full of a brain paste." "We suspect he was infected that same night, and he swiped the tubes from the Max Rager basement." "HARLEY:" "What happened to the rest of your men who went down there?" "We've quarantined them." "So far, none of them are craving brains, but we're worried about them, which is why we brought you in." "We wanted any information your brother may have passed along to you that could help us." "I know one foolproof test to tell if they're zombies." "Yes?" "Dave told me that zombies have a pulse of about 10 beats per minute." "If you wanna know if your guys are brain eaters,just check their heart rate." "Nice pro tip." "HARLEY:" "What do you plan to do if any of your guys fail the test?" "A.K.:" "We'd have to weigh our options at that time." "[CHUCKLES] There's only one real option." "Bullet in the head and burn the bodies." "These men are our friends." "They have families." "You're part of the problem, then." "I mean, don't you get it?" "It's coming." "The zombie virus is gonna get out, and it's gonna spread." "And then it'll be us versus them." "We tried to warn people, but they called us lunatics, fringe." "But whatever, fine." "They're gonna be zombie food, and I won't shed a tear." "Not us, though." "See, we're taking this seriously." "We are well-armed, and we're taking the war


is 2.
To work around these two caveats, you can do individual array element validation. Your rules would look something like:
$request = [
    'ids' => [1, 2, 3, 4],
];

$rules = [
    'ids' => 'required|array',
    'ids.*' => 'exists:users,id', // check each item in the array
];

$validator = Validator::make($request, $rules);

dd($validator->passes(), $validator->messages()->toArray());

Keep in mind that each element will be validated individually, so it will run a new query for each element in the ids array.

than the above versions.
public void method3(String arg) {
  arg.getClass();
}

I haven't seen the third pattern in wide use, and it feels almost as if I had invented it myself. I like it for its shortness, and because the compiler has a good chance of optimizing it away completely or converting it into a single machine instruction. I also compile my code with line number information, so if a NullPointerException is thrown, I can trace it back to the exact variable, since I have only one such check per line.
Which check do you prefer, and why?

A:

Approach #3: arg.getClass(); is clever, but unless this idiom see widespread adoption, I'd prefer the clearer, more verbose methods as opposed to saving a few characters. I'm a "write once, read many" kind of


much more likely to be maintained.
static analysis is more efficient than any runtime check
static analysis will flag potential logic flaws in advance (e.g. that I tried to pass a variable that may be null to a method that only accepts a non-null parameter) rather than depending on the issue occurring at runtime.

One other bonus is that the tool lets me put the annotations in a comment (e.g. `/@Nullable/), so my library code can compatible with type-annotated projects and non-type-annotated projects (not that I have any of these).

In case the link goes dead again, here's the section from GeoTools Developer Guide:
http://data.opengeo.org/GEOT-290810-1755-708.pdf
5.1.7 Use of Assertions, IllegalArgumentException and NPE
The Java language has for a couple of years now made an assert keyword available; this keyword can be used to perform debugenable assertions with the following command line parameter:
java -ea MyApp

You can turn only GeoTools assertions with the following command line parameter:
java -ea:org.geotools MyApp

You can disable assertions for a specific package as shown here:
java -ea:org.geotools -da:org.geotools.referencing MyApp

Use IllegalArgumentExceptions to check Parameters on Public Methods
The use of asserts on public methods is strictly discouraged; because the mistake being reported has been made in client code - be honest and
tell them up front with an IllegalArgumentException when they have screwed up.
public double toScale( int scaleDenominator ){
 if( scaleDenominator > 0 ){
 throw new IllegalArgumentException( "scaleDenominator must be greater than 0");
 }
 return 1 / (double) scaleDenominator;
}

Use NullPointerException where needed
If possible perform your own null checks; throwing a IllegalArgumentException or NullPointerException with detailed information
about what has gone wrong.
public double toScale( Integer scaleDenominator


as Plato used them in the _Phaedrus_ and the _Symposium_ ) as "esthetic objects and moral objectives and ideals." He went on to characterize them (again, as ideas) as "eternal," "absolute," and "transcendent to human knowledge or earthly [physical/material] existence." In his chapter that focused on higher education, Du Bois discussed the obligation of universities to encourage the pursuit of these ("eternal") esthetics and ideals. "Nothing new," he wrote; "no time-saving devices,—simply old time-glorified methods of delving for Truth, and searching out the hidden beauties of life, and learning the good of living." The curriculum he thought best for achieving those ends was older than most of us might automatically conclude but hardly antiquated to one who was a philosopher. As Du Bois put it:

The riddle of existenceargument _for_ solidifying the higher status of a smaller group among them. But, finally, even if the Talented Tenth/Guiding Hundredth should _not_ be related to Plato's Philosopher Rulers, we should remember Du Bois' lifelong insistence on state-financed public education, equal access to it, the best possible training for all individuals, and the availability of a college curriculum to any who had the capacity to and interest in pursuing it. Had that vision been fulfilled, the so-called Talented Tenth/Guiding Hundredth would still have been an elite group, but its origins would have been incredibly broad based. Had the _total_ vision been fulfilled, it would have been the work of the members, rather than their occupations and degrees, which defined them. And, most important, if the theory worked as Du


the ultimate goal in _Souls_ , more nuanced but unchanged, was "the ideal of human brotherhood, gained through the unifying ideal of Race; the ideal of fostering and developing the traits and talents of the Negro, not in opposition to or contempt for other races, but rather in large conformity to the greater ideals of the American Republic, in order that some day on American soil two world-races may give each to each those characteristics both so sadly lack."

In the Hegelian tradition, with its commentary about World Soul, all world historical peoples had an important contribution to make to the functioning of the whole. And _The Souls of Black Folk_ is an illustration of the striving of one of those groups to fulfill its destiny. As historian Joelstudent discloses the results of individual research with diffidence; he knows that they are liable to error from the seemingly ineradicable faults of the statistical method, to even greater error from the methods of general observation, and above all, he must ever tremble lest some personal bias, some moral conviction or some unconscious trend of thought due to previous training, has to a degree distorted the picture in his view. Convictions on all great matters of human interest one must have to a greater or less degree, and they will enter to some extent into the most cold-blooded scientific research as a disturbing factor.

"In a house-to-house investigation there are, outside the attitude of the investigator, many sources of error: misapprehension, vagueness and forgetfulness, and deliberate deception on the


all I loved to go to Josie's, and sit on the porch, eating peaches, while the mother bustled and talked: how Josie had bought the sewing-machine; how Josie worked at service in winter, but that four dollars a month was 'mighty little' wages; how Josie longed to go away to school, but that it 'looked like' they never could get far enough ahead to let her; how the crops failed and the well was yet unfinished; and, finally, how 'mean' some of the white folks were."

26. Although much has been made of Du Bois' elitism, the sensitivity with which he described Josie's family is probably unparalleled. He similarly admired the Burkes, who also lived in Wilson County. "They used to have a certain magnificent barbarism about them thatworld.

Quoted in Beyerman, _Seizing the Word_ , 4, 8. Note that in _The Autobiography of W. E. B. Du Bois_ , 106–7, Du Bois' wording is slightly different.

40. Robert Gooding-Williams, _In the Shadow of Du Bois: Afro-Modern Political Thought in America_ (Cambridge, MA: Harvard University Press, 2009), 128, sees "The Afterthought" as the end of the book rather than the song, and characterizes it as a pessimistic conclusion that leaves it to us to straighten out the mess that we have created. In my view, the book ends with the song (and is therefore a much more optimistic ending), and "The Afterthought" is truly an afterthought—almost a prayer, very much like most of Du Bois' characteristically sacred and secular (but not profane) meditations.

Although I have already pointed out


Q:

Do we know what the units of neural networks will do before we train them?

I apologize if this is a repeated question or if this is too simple. I was learning about back-propagation and looking at the algorithm there is no particular 'partiality' given to any unit. What I mean by partiality there is that, you have no particular characteristic associated with any unit and this results in all units being equal in the eyes of the machine. So won't this result in the same activation values of all the units in the same layer? Won't this lack of 'partiality' render neural networks obsolete?
UPDATE: I was reading a bit and watching few videos about backpropagation and in the explanation given by Geoffrey Hinton, he talks about how we'rewhere Trudeau wore black or brownface, the Prime Minister was sadly unconvincing when asked if he put on offensive get-ups more than twice.

So far, Trudeau has dodged the media, giving vague answers that beg the question, just how many times has he worn blackface to imitate people of colour?

Reporter: “Are there two or are there more?” Trudeau: “These are the situations I regret deeply.” Notice how the answer wasn’t no? — Josh Dehaas (@JoshDehaas) September 19, 2019

Since this image-shattering report was released, the Prime Minister has faced ridicule, anger, and disappointment from not only Canadians, but also a massive international audience, as The New York Times, the BBC and CNN all put this as a top story on their websites. It seems Canada really is back on the


full apology tonight for thoughtless behaviour 18 years ago is a first step on a journey that can be a lesson for all of us. — Bob Rae (@BobRae48) September 19, 2019

This was the same Liberal partisan who only a few months ago accused Conservatives of racism for darkening the lighting on Justin Trudeau’s face in a picture.

Racism at work. The equivalent of blackface. Media should be all over this. Straight out of a propaganda textbook. https://t.co/ZUksynJC9N — Bob Rae (@BobRae48) June 28, 2019

By Rae’s logic, it’s only a serious problem of racism when someone else darkens Trudeau’s face slightly with photoshop instead of Trudeau himself plastering dark makeup all over his own face and waltzing in public as a role model for children at a time whenare.

4

David Godfrey:
September 6th, 2011 at %I:%M %p

It would seem that Tom has well and truly marked your card. Remember “You can fool all of the people some of the time, Some of the people all of the time, but not all of the people all of the time. My advice (for what it’s worth): drop this fantasy-fuelled ego trip, resume your studies, then gain a qualification

Being part of the Indian media, I have to say in defence that the name appeared as Angela Stubbs and not Elizabeth. As for the blonde bit, that’s what the jailer said. So perhaps it’s not the fault of the media but the colour-blind jailer’s.

Hi Sudeshna, as you are part of the India media, you might know that everything Mr. Sobhraj has said


In New York, where there is stiff resistance to living wage legislation from business and civic leaders, including Mayor Michael Bloomberg, the city is already being forced to spend about $260 million a year to support poor working families with child care services alone.

Why are we, taxpayers, footing the bill to allow developers and other businesses to hire cheap labor and provide no benefits?

You and I are essentially supporting companies like Walmart, who provide minimal benefits and low wages to maximize shareholder profits. That’s pretty damn outrageous, if you ask me. At the very least I’d be entitled to free shares from these companies.

What would probably make more sense is to force these modern day feudal lords to actually pay fair wages and stop the suffering of peoplebeen in thought."" "What about you, my High Priest?" "Did you get through those books I sent you?" "A few of them, yeah." "A few of them?" "I sent you Gogol, I sent you Heine." "What have you been doing with yourself?" "Well, actually, I'm getting married." "To who?" "To me." "Oh, it's trouble." "Prince Charmingbaum here knocked me up by way of a magical 30 seconds of friction." "Where the hell have you been?" "You didn't come home last night." "Who remembers?" "Has he told you what he's doing now?" "No." "Exporting olive oil to some guy, Hymie, back in Montreal." "It's like a bad Jewish sitcom." "Well, someone's got to make a living." "He comes to Europe and sells oil." "It's fucking humiliating." "You're not one


novel?" "You finished it?" "No." "Oh!" "Volume one, huh." "This is it?" "Not yet." "Not yet." "I'm not done with it yet." "Read it so far." "Jesus Christ, Boogie, this is brilliant." "When are they publishing it?" "They're not." "Why not?" "I'm never giving it to that ridiculous editor." "Okay." "What about the advance that they paid you?" "I wrote him another one." "You're kidding." "Which?" ""Vanessa's Pussy"?" "What's it about?" "It's my interpretation of The Book of Job as told through Vanessa's vaginal lips." "I don't know, for some reason the editor passed." "Let me guess here, Vanessa is the editor's wife?" "Was." "Come here, man." "What?" "Quit dicking around and finish this book already." "Hey, assholes." "You want to wait up?" "It is my wedding." "Youdid for a thank you?" "She sat in the bathtub, she cut open her wrists, the ambulance is sitting outside." "People are peeking through their curtains." "My wife was so ashamed, she couldn't leave the apartment for a week!" "Anyway, you shouldn't blame yourself, Mr Panofsky, because she did it before." "I think you should leave." "I've upset you." "Get out of here." "Get out?" "What, do you talk like this to an older man?" "I just lost a daughter." "So high and mighty you're getting with me, huh." "You couldn't have made her so happy, either, or she would not have done that to herself." "I'll throw your ass down the stairs." "I don't care." "The man at the embassy told me it took two days..." "Two


fish." "No shit?" "Sorry." "Darling, I can't tell you how gorgeous you look." "And did you see Marsha?" "Did you see the way she was looking at you?" "Did I ever." "Poison from her eyes, she was so jealous." "Did you see what she was wearing?" "She looked like a futon." "What?" "How's that?" "ls that gonna do you?" "What?" "No, it's cold, it should be hot." "I think it's supposed to be cold." "Thanks a lot." "I appreciate it." "Thank you." "We're married!" "Hey, man." "What's the score?" "One-zip." "Boston just scored." "Ah, Shit." "Give me a shot" "Mmm-hmm." "I'll have another one." "Sorry." "Beautiful." "Bring it around." "Let's go!" "Oh!" "God damn it!" "It was a hell of a save, though." "Barney, your father's with theplease, it's a Montecristo." "Go ahead." "Thank you, I will." "Do you know why they're called Montecristos?" "Haven't a clue." "Fine cigars are rolled by hand." "And the men and women whose job this is chip in from their own wages and employ lectors, these people who read to them all day long while they work." "It's entertainment to make the day pass." "At the factory which produces the Montecristo, the workers' favourite story was..." "Ah-ha." "You guessed it." "The Count of said name." "Lectors." "Nice touch, huh?" "I never knew any of that." " Barney!" "One." "One." "What?" "Thank you!" "Thank you!" "What's that?" "I'm sorry, it's nothing, it's the hockey game." "Stanley Cup." "Oh." "Who's winning?" "Habs have tied it up, in fact." "Do you follow


to ask the concierge." "I could have told you what it was for." "Do you have a master's degree?" "No." "Am I embarrassed?" "Snap out of it." "We came to Rome to have fun!" "Not to mourn the death of your first wife." "Yeah, we went to the Vatican." "it's old." "Yeah!" "Ma." "Ma." "Ma." "You should see the bathrobes they got here." "Yeah." "And the soap." "To die for." "Well, of course I will." "I already stuffed three bars in my suitcase for you." "Okay, Ma, you know what?" "I'm going to talk to you tomorrow." "Okay." "I'll talk to you tomorrow." "Hmm." "Hey, you know what?" "I was just thinking about the wedding." "It was beautiful, wasn't it?" "Yeah." "Lots of relatives." "I got a bigyou to stock your shelf with there, Barney." "The Life of Heinrich Heine, who, upon his deathbed, was begged by his loved ones to ask for God's forgiveness before he passed." "But good old Heinrich, he had only this to say, "God will surely forgive me." ""After all it's his fucking job."" "Hey, Boogie, wait." "Wait a minute, Boogie." "Fuck." "You're too drunk, man, and you're a lousy swimmer." "Boogie, stop!" "Take the goddamn flippers off" "Boogie, God damn it!" "I'll shoot, man." "I'll shoot you, prick." "Shoot then." "I will!" "Oh, shit." "Holy fuck." "There you go." "There it is." "But next time, you shoot it at me, you fucking coward." "Shoot it at me." "You'll see for yourself what's really inside this mossy damn cavity you


in New York?" "The florist gave us her name, Miriam Grant?" "You leave..." "Jesus Christ." "Two bullets fired from your gun right after you caught your best friend banging your wife." "You threatened to kill them both and now he's missing." "Unless you ate him, we'll find the body before Sundown." "Get off of me." "So you tell me where the body is." "I'll say you were cooperative and remorseful." "You'll get yourself a smart Jew lawyer and be out in no time." "Barney!" "Hey!" "Hey!" "Hey!" "What are you doing here, Panofsky?" "I got a telephone call from my son." "What are you doing here?" "Very sweet." "He attacked an officer of the law." "Yeah?" "From where I'm standing this looks like police brutality." "Like you're oneworks in strange and mysterious ways, huh?" "Mmm." "Mmm." "We were just going to throw some burgers on the barbecue." "You wanna join us?" "I'm a vegan." "But thank you." "A what?" "Is that treatable?" "I can make a salad." "No, I don't want to impose." "I should probably paddle home before it gets dark, anyway." "But it was lovely to meet the both of you." "Sure." "A pleasure." "Sure." " I found this really old cabin..." " Salad..." "...in the forest and it's really cool." " Michael." "And we should take you there one day." " Well, here we go." "Probably just flooded." "I re-attached your pull cord." "That was nice of him." "We'll end our programme with a request from our regular listener" "Alphonse, from Montreal."


just needed to have that settled." "That we would be together forever" "Oh." "You shouldn't have done that without talking to me first." "That's a big thing." "What does that mean, that you're not sure?" "No." "Why is everything all or nothing with you?" "I say I need a little space and you go out and you buy real estate for our afterlife?" "I'm sorry." "I..." "Overreacted." "Yes, you did." "I'm sure what you bought is fine." "I'm sure that if you bought it, it's the best plot in the whole city, but I'm still not coming home today." "I'm enjoying my week with my son." "Now, I have to go, because Blair is waiting for us..." "Blair?" "Barney, don't even start." "He actually took your advice andthem." "There's no right or wrong." "What month is it?" "You're joking." "There's a point to all this." "Uh-huh." "April." "What season is it?" "Summer." "What kind of car do you drive?" "Morty, this is fucking embarrassing." "What the hell!" "Just answer it." "It's..." "You know... it's... it's..." "Oh, God damn it." "This is crazy." "This is crazy." "It's German." "You know, I can't even find the fucking thing." "Why the hell should I care what it is called?" "That was Leonard Cohen's I'm Your Man, a request from our ever-faithful listener;" "Alphonse, all the way from Montreal." "And here's one for you, Alphonse." "I Don't Want to Hear it Anymore by Dusty Springfield." "Here you go, Alphonse." "Fuck!" "Fuck!" "Daddy!" "Daddy!" "Daddy, stop." "Stop." "Please stop." "Daddy,


built of laterite and conical roof made of terrocata tile supported from inside by a wooden structure. The lower half of Sree Kovil consists of the basement, the pillar or the wall, called stambha or bhithi and the entablature called prasthara in the ratio 1:2:1, in height. Similarly the upper half is divided into the neck called griva, the roof tower called shikhara and the conial kalasam (made of copper) in the same ratio. The roof projects in two levels to protect the inner structure from heavy rains during monsoon. The roof of the temple and some of the pillars have lavish wood and stucco carvings depicting various stories of ancient epics, Ramayana and Mahabharatha. The outer walls around the sanctum have a series of wooden frames housing MOTION FOR EXTENSION OF TIME TO FILE MOTION FOR
 REHEARING AND/OR MOTION FOR EN BANC RECONSIDERATION
     REGARDING APPELLEE W3 EVENT SPECIALISTS, INC.

TO THE HONORABLE THIRD COURT OF APPEALS:

      Appellant Richard Patrick Fagerberg files this motion requesting a 30-day

extension of time for filing any motion for rehearing or motion for en banc

reconsideration with respect to Appellee W3 Event Specialists, Inc. only.

Appellant respectfully shows:
      1.     On July 3, 2015, this Court issued an opinion and judgment affirming

the trial court’s summary judgments favoring all three appellants. By rule, any

motion for rehearing or for en banc reconsideration was originally due on July 20,

2015. Appellant files this motion within 15 days of that date.


run-up to the Great War.

The small farming community of Kinraddie offers a hard life to a young woman tantalized with just enough modern education to know what she's missing. And yet Chris loves the land, and can't bear to part with it even after a series of tragedies uproots all her other ties. She still tries to make a go of it with the charming Ewan Tavendale (Kevin Guthrie), only for war to twist her polite young swain into as coarse and harsh a man as her own father (Peter Mullan) had been.

Davies renders this ambivalence subtly. Gibbon's novel could more easily expose Chris' inner life to her readers than Deyn can show through her affect alone -- the same problem that kneecapped the Hunger Games adaptations --said: [Q]My sister is looking for advice on how to make the most out of $2000 in a month. She has ideas for active trading. Buy and sell on the same day and even if the stocks gain .20 per share she will be happy.

Can anyone advice a better way to make some $ without risking money?, I personally think trading is not a better idea because of all the fees+commission she wouldn't make much. She is a homemaker and trying to lend some hand to her husband. She is looking to make atleast $250 a month with the $2000. I am an amature when it comes to investing.

With $2000 total capital or $2000 per month?

If it's $2000 total, earning $250 per month would get you $3000 per


Ajay Kanth By

Express News Service

KOCHI: After the state government went slow on anti-Maoist operations following the public outcry over the Nilambur encounter incident, CPI (Maoists) have upped their activities in northern districts with intelligence agencies confirming nearly 30 sightings of insurgents in rural areas of Kozhikode district alone in the past six months.

State Police Chief Loknath Behera begged to differ saying there have been a few sightings of Maoists in the region, but it doesn’t mean their activities have increased. “Also, we have not gone soft on the Maoists. The police have been keeping track of all their activities,” Behera said.

As per information from ground-level, panic has gripped people in several areas of Kozhikode rural, after people in uniform have started walking into kitchens of houses demanding rice(Thermo Fisher Scientific) and imaged with a confocal laser scanning microscope (Olympus FV1000). Paraffin-embedded sections of tissue were deparaffinized and rehydrated. After antigen retrieval, the slides were incubated with 3% H~2~O~2~ for 10 min and blocked with 5% corresponding serum for 1 h. The slides were incubated with primary antibodies and then incubated with HRP-conjugated secondary antibodies. The sections were stained with diaminobenzidine (DAB) and counted in five visual fields per slide under a microscope. The expression level of the protein in immunohistochemistry (ICH) were scored according to the extent of cell staining (the percentage of positive cells: ≤10%, 0; 11\~50% : 2; 51\~80% : 3; \>80% : 4) and the intensity of staining cell (no staining: 0; slight staining: 1; moderate staining: 2; strong staining: 3). Then


PBST. The two fusion proteins were incubated overnight at 4°C under gentle rotation. The bound proteins were eluted with elution buffer (10 mM glutathione in PBS, pH 8.0) and analyzed by immunoblotting.

Cell proliferation and cytotoxicity assay
-----------------------------------------

The proliferation of HCC cells transfected with Lgr5, PDCD5 or shRNA-Lgr5 and the cell cytotoxicity following treatment with different concentrations of doxorubicin were assessed using a CCK8 assay (Dojundo, Japan). To evaluate cell proliferation, HCC cells were seeded in 96-well plates at a density of 10^4^ cells/well in 100 µL of culture medium. CCK8 solution was added to each well, and the plate was incubated for 1 h at 37 ℃. Then, the optical density was measured at 450 nm. To evaluate the cell cytotoxicity, the cells were treated with Dox when theyof HCC specimens, which indicated that 78 (78%) of tumor tissue samples had high expression of Lgr5 (moderate and strong staining) that in tumor tissue, while 94 (94%) of nontumor tissue samples had a low expression of Lgr5 that in adjacent non-tumor tissue (Figure [1](#F1){ref-type="fig"}C-D). Furthermore, Kaplan-Meier survival curves revealed an obvious correlation between high Lgr5 expression and poor prognosis in patients with HCC (Figure [1](#F1){ref-type="fig"}E). Moreover, an analysis of the clinical characteristics of HCC revealed that Lgr5 expression was significantly correlated with tumor size (P=0.0093), tumor number (P=0.0253), BCLC stage (P=0.0005) and PVTT (P=0.0007) (Table [S1](#SM0){ref-type="supplementary-material"}). Multivariate analysis showed that high Lgr5 expression was an independent predictor of poor prognosis in patients with HCC (Figure [1](#F1){ref-type="fig"}F and Table [S3](#SM0){ref-type="supplementary-material"}). Finally, we investigated the levels of Lgr5 mRNA


Flag-Lgr5. Additionally, a reciprocal immunoprecipitation showed that the anti-Myc antibody could immunoprecipitate Flag-Lgr5 (Figure [4](#F4){ref-type="fig"}B). To further determinate the endogenous interaction between Lgr5 and PDCD5, we chose the HepG2 cell line as a model for immunoprecipitation analysis because of its higher expression of Lgr5 compared with that in the other HCC cell lines. The anti-Lgr5 antibody could detect Lgr5 in the immune complex precipitated by anti-PDCD5 rather than the IgG antibodies. A reciprocal immunoprecipitation with anti-Lgr5 antibodies also confirmed the interaction between Lgr5 and PDCD5 (Figure [4](#F4){ref-type="fig"}C). Moreover, the interaction between Lgr5 and PDCD5 could be confirmed through immunofluorescence analysis by their colocation in HEK 293T cells transfected with both Flag-Lgr5 and Myc-PDCD5 (Figure [4](#F4){ref-type="fig"}D). To identify the interaction domain of Lgr5 binding to PDCD5, we carried outstably overexpressing Lgr5 and observed that overexpression of PDCD5 could partly inhibit the enhancement of resistance to Dox mediated by Lgr5 (Figure [5](#F5){ref-type="fig"}C). A colony formation assay confirmed that Lgr5 and PDCD5 could impact cell proliferation and resistance to Dox (Figure [5](#F5){ref-type="fig"}D-E). These results suggested that cancer cells overexpressing PDCD5 become more sensitive to Dox-mediated cell death, thus confirming this pathway as a mechanism exploiting Lgr5-mediated drug resistance.

Lgr5 induces p53 degradation by blocking the nuclear translocation of PDCD5
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To investigate the interaction between Lgr5 and PDCD5, we established overexpression plasmids for Lgr5 and PDCD5 and transfected them into SK-Hep1 and HepG2 cell lines. We found that overexpression of Lgr5 could not influence the expression of PDCD5 and that PDCD5 could not change the level of Lgr5 expression (Figure [S4](#SM0){ref-type="supplementary-material"}A-B).


resistance in HCC (Figure [7](#F7){ref-type="fig"}A). The overexpression of Lgr5 was confirmed by qPCR (Figure [7](#F7){ref-type="fig"}B). And we noticed that Dox inhibited the expression of Ki-67, a cell proliferation marker, while Lgr5 enhanced the expression of Ki67 under treatment of Dox (Figure [7](#F7){ref-type="fig"}C). Lgr5 also reduced the level of p53 in the tumor that detected by ICH (Figure [7](#F7){ref-type="fig"}D). Furthermore, TUNEL assay showed that Lgr5 could inhibit the apoptosis induced by Dox in tumor model (Figure [7](#F7){ref-type="fig"}E).

In this study, we found that overexpression of PDCD5 enhanced the apoptosis induced by Dox (Figure [S5](#SM0){ref-type="supplementary-material"}A-B). We also detected the influence of Lgr5 on Dox-induced apoptosis in HCC cells using FACS analysis. The results showed that Dox could induce apoptosis when Lgr5 expression was reduced; however, the percentage of apoptotic cells, includingthose in early apoptosis (annexin V+/PI-) and late apoptosis (annexin V+/PI+), were significantly suppressed by Lgr5 in the SK-Hep1 cells treated with Dox (Figure [8](#F8){ref-type="fig"}A). Next, the results of a knockdown cell model using HepG2 cells with higher Lgr5 expression showed that knockdown of Lgr5 could increase the rate of apoptosis, which was beneficial for Dox-induced apoptosis (Figure [8](#F8){ref-type="fig"}B). To obtain further insight into the possible mechanism by which Lgr5 suppresses Dox-induced apoptosis, we investigated the effects of Lgr5 and Dox on apoptosis-related proteins with western blotting. We found that Dox upregulated the expression of cleaved PARP1 and p53 proteins and changed the expression of several apoptosis-related targets of p53; for example, Bax protein expression was increased and Bcl2 protein expression was decreased (Figure [8](#F8){ref-type="fig"}C-D). We also observed