mechanical adaptive plasticity in conditions of physical stress.

STAR★Methods {#sec4}
============

Key Resources Table {#sec4.1}
-------------------

REAGENT or RESOURCESOURCEIDENTIFIER**Antibodies**Rabbit ACTN4AbcamCat\# ab108198; RRID: [AB_10858236](nif-antibody:AB_10858236){#interref0060}Rabbit ARP3Abcamab151729Rabbit CORTACTINCell SignalingCat\# 3503; RRID: [AB_2115160](nif-antibody:AB_2115160){#interref0065}Rabbit ITGB1Santa CruzCat\# M-106; RRID: [AB_2130101](nif-antibody:AB_2130101){#interref0070}Guinea pig NEPHRINProgeneCat\# Gp-N2Rat Nidogen (ELM1)Nordic-MUbioCat\# X1778MRabbit NMHC-IIACovanceCat\# PRB-440P; RRID: [AB_291638](nif-antibody:AB_291638){#interref0075}Rabbit NWASPCell SignalingCat\# 4848S; RRID: [AB_10694415](nif-antibody:AB_10694415){#interref0080}Mouse PAXILLINBD Transduction Lab.Cat\# 610051Mouse PDH E2/E3AbcamCat\# ab110333; RRID: [AB_10862029](nif-antibody:AB_10862029){#interref0085}Rabbit P-MLCCell SignalingCat\# 3671/3674; RRID: [AB_2147464](nif-antibody:AB_2147464){#interref0090}Rabbit PODOCINSanta CruzCat\# P0372; RRID: [AB_2267439](nif-antibody:AB_2267439){#interref0095}Mouse SYNPOProgeneCat\# 65194Mouse TubulinSigmaN/AMouse VinculinAbcamCat\# SPM227; RRID: [AB_883461](nif-antibody:AB_883461){#interref0100}Rabbit WAVE2 (WASF2)Atlas AntibodiesCat\# HPA045288; RRID: [AB_2679287](nif-antibody:AB_2679287){#interref0105}Mouse WT-1MilliporeCat\# 05-753-clone 6F-H2; RRID: [AB_309966](nif-antibody:AB_309966){#interref0110}Rabbit YAPCell SignalingCat\# 14074S; RRID: [AB_2218911](nif-antibody:AB_2218911){#interref0115}Rabbit ZYXINAtlas AntibodiesCat\# HPA004835; RRID: [AB_1080771](nif-antibody:AB_1080771){#interref0120}Cy™3 AffiniPure Donkey AntiGuinea Pig IgG (H+L)Jackson ImmunoCat\# 706-165-148Alexa fluor (488,555,633 -- resp. species)Thermo Fisher ScientifcN/ADAPIThermo Fisher ScientifcCat\# D21490LTGVector LaboratoriesCat\# FL-1321; RRID: [AB_2336559](nif-antibody:AB_2336559){#interref0125}DBAVector LaboratoriesCat\# RL-1032; RRID: [AB_2336396](nif-antibody:AB_2336396){#interref0130}Alexa Fluor Phalloidin (546, 488)Thermo Fisher ScientifcCat\# A22283, A12379; RRID: [AB_2315147](nif-antibody:AB_2315147){#interref0135}**Biological Samples**AllSlice cultures were treated with DMSO as control or with 100μM CK869 for 3 hours. After treatment, kidney slices were fixated and processed for SEM.

### Super Resolution Microscopy (SIM) {#sec4.4.4}

For evaluation of the slit diaphragm density as a direct marker for podocyte effacement, we used the recently established super resolution microscopy-based podocyte effacement measurement procedure (PEMP) ([@bib61]). Briefly, 2 μm paraffin sections were performed and cooked in 10 mM citrate buffer (pH 6) in a pressure cooker. After blocking in 1% normal goat serum, 1% bovine serum albumin, 1% fetal calf serum and 0.05 % fish gelatin for 1 h at room temperature, guinea pig anti-nephrin serum (gpN2, Progene, Heidelberg, Germany, diluted 1:300 in blocking solution) was incubated at 4°C overnight. After washing steps (PBS) followed by a second blocking step,


separation prior MS analysis. Samples were loaded with 500 nl/min, and the gradient was conducted at 250 nl/min. A gradient of Buffer A (0.5% acetic acid in deionized water) and Buffer B (0.5% acetic acid, 80% ACN in deionized water) with increasing ACN proportion was used for peptide separation. Samples were loaded onto the column with 2% Buffer B; a 100 min separation gradient was run up to 35% buffer B. The ion--transfer tube temperature was set to 200°C and the spray voltage was 2.3 kV with no sheath and auxiliary gas flow. Data was acquired in the data--dependent mode and switched automatically between MS (max. of 1x10^6^ ions) and MS/MS (max. of 5000 ions). In the linear ion trap the top five abundant peptides were isolated and fragmentedwas followed by final mounting in Prolong Gold antifade (Invitrogen, Schnelldorf).

### Isometric Cycling Stress (Flexcell) {#sec4.4.12}

Primary and immortalized human podocytes were seeded on collagen IV coated flexible biomembranes (Flexcell International Corporation; Burlington, USA) and after a 12 hour cultivation period transferred to the Flexcell manipulator. According to previous studies ([@bib55]) stretch of 7% and 0.5 Hz cycling were applied for a total duration of 24 hours. After stress application cells were fixed and further analyzed. For detachment quantification, at least 15 low power fields were randomly chosen and automatically analyzed for attached nuclei; experiments were repeated 3 times independently.

### Traction Force Microscopy {#sec4.4.13}

Traction force microscopy is an established method for quantification of cellular forces exerted on the underlying substratum ([@bib56]). Previously established protocols for preparation of substratum matrices were


in the figure legends.

### Glomerluar Sclerosis Index {#sec4.5.2}

To quantify glomerular sclerosis a previously established scoring method was adapted and modified ([@bib16]). The degree of sclerosis and alteration of glomeruli was categorized according to following criteria: grade I -- normal appearing glomeruli, grade II -- mild to moderate alterations, at least one feature like mesangial hypercellularity or partial sclerosis (\<50% of total glomerulus), grade III -- totally sclerosed glomerulus. 50-60 glomeruli per animal were assessed and counted in a blinded manner. A total number of 3-4 animals per time point and genotype were analyzed.

### Immunofluorescence Quantification {#sec4.5.3}

ppMLC intensity/area per glomerulus was quantified by segmentation of the podocyte compartment using Nephrin immunofluorescence as a specific marker. \>20 glomeruli per animal were analyzed and the mean podocyte ppMLC intensity/area per animalwas calculated. The percentage of YAP positive podocyte nuclei was analyzed by immunofluorescence staining for YAP and the podocyte specific nucleus marker WT1. \>20 glomeruli per animal were analyzed and the mean percentage of YAP positive podocyte nuclei per animal was calculated.

### Quantification of Foot Process Morphology and Branching Index {#sec4.5.4}

Image analysis was performed using Image J 4.17 and Adobe Photoshop CS6. Measurement of foot process width was essentially performed as described before ([@bib38]). Briefly, numbers of podocyte processes were divided by the length of the GBM region in every image. Branching levels of podocyte major processes were calculated from semi-planar SEM areas. Therefore branches per major trunk were counted and the ratio of branches per μm length was calculated (10-23 major processes per animal were analyzed and


of the image and binarization, 3.) measurement of area, major and minor axis using the particle analyzer function of ImageJ NIH (lower cutoff 0.2 Pixels). Output data were collected for individual cells and analyzed using Microsoft Excel and GraphPad Prism. Quantification of IF signal intensity was basically performed as described previously ([@bib1]) : Images were background subtracted and the area of individual cells was outlined manually. Fluorescence intensity in the outlined area was recorded and background intensity was subtracted. Cellular immunofluorescence intensities were normalized for cell area and plotted using GraphPad Prism. Line scans were performed using the plot profile tool of ImageJ/Fiji NIH software (PlotProfile).

### Cell Migration {#sec4.5.6}

Tracking of individual cells was performed using ImageJ 1.47 NIH software package and the manual tracking plugin (<http://rsbweb.nih.gov/ij/plugins/track/track.html>). Resulting xypackage com.seattleshelter.core.api;

import java.lang.System;

@kotlin.Metadata(mv = {1, 1, 15}, bv = {1, 0, 3}, k = 1, d1 = {"\u0000.\n\u0002\u0018\u0002\n\u0002\u0018\u0002\n\u0000\n\u0002\u0018\u0002\n\u0002\b\u0002\n\u0002\u0018\u0002\n\u0002\u0018\u0002\n\u0000\n\u0002\u0010\t\n\u0000\n\u0002\u0010 \n\u0002\u0018\u0002\n\u0002\b\t\b\u0000\u0018\u00002\u00020\u0001B\r\u0012\u0006\u0010\u0002\u001a\u00020\u0003\u00a2\u0006\u0002\u0010\u0004J\u0016\u0010\u0005\u001a\b\u0012\u0004\u0012\u00020\u00070\u00062\u0006\u0010\b\u001a\u00020\tH\u0016J\u0014\u0010\n\u001a\u000e\u0012\n\u0012\b\u0012\u0004\u0012\u00020\f0\u000b0\u0006H\u0016J\u0016\u0010\r\u001a\b\u0012\u0004\u0012\u00020\u00070\u00062\u0006\u0010\b\u001a\u00020\tH\u0016J\u0014\u0010\u000e\u001a\u000e\u0012\n\u0012\b\u0012\u0004\u0012\u00020\f0\u000b0\u0006H\u0016J\u0016\u0010\u000f\u001a\b\u0012\u0004\u0012\u00020\u00070\u00062\u0006\u0010\b\u001a\u00020\tH\u0016J\u0014\u0010\u0010\u001a\u000e\u0012\n\u0012\b\u0012\u0004\u0012\u00020\f0\u000b0\u0006H\u0016J\u0016\u0010\u0011\u001a\b\u0012\u0004\u0012\u00020\u00070\u00062\u0006\u0010\b\u001a\u00020\tH\u0016J\u0014\u0010\u0012\u001a\u000e\u0012\n\u0012\b\u0012\u0004\u0012\u00020\f0\u000b0\u0006H\u0016J\u0016\u0010\u0013\u001a\b\u0012\u0004\u0012\u00020\u00070\u00062\u0006\u0010\b\u001a\u00020\tH\u0016J\u0014\u0010\u0014\u001a\u000e\u0012\n\u0012\b\u0012\u0004\u0012\u00020\f0\u000b0\u0006H\u0016R\u000e\u0010\u0002\u001a\u00020\u0003X\u0082\u0004\u00a2\u0006\u0002\n\u0000\u00a8\u0006\u0015"}, d2 = {"Lcom/seattleshelter/core/api/PetsServiceImpl;", "Lcom/seattleshelter/core/api/PetsService;", "service", "Lcom/seattleshelter/core/api/InnerPetsService;", "(Lcom/seattleshelter/core/api/InnerPetsService;)V", "getCatById", "Lio/reactivex/Single;", "Lcom/seattleshelter/entities/PetDetails;", "id", "", "getCatsList", "", "Lcom/seattleshelter/entities/Pet;", "getDogById", "getDogsList", "getRabbitById", "getRabbitsList", "getReptileById", "getReptilesList", "getSmallMammalById", "getSmallMammalsList", "core_debug"})
public final class PetsServiceImpl implements com.seattleshelter.core.api.PetsService {
    private final com.seattleshelter.core.api.InnerPetsService service = null;

    @org.jetbrains.annotations.NotNull()
    @java.lang.Override()
    public io.reactivex.Single<java.util.List<com.seattleshelter.entities.Pet>> getCatsList() {
        return null;
    }

    @org.jetbrains.annotations.NotNull()
    @java.lang.Override()
    public io.reactivex.Single<com.seattleshelter.entities.PetDetails> getCatById(long id) {
        return null;
    }


deficiency of NHEJ components significantly elevating HR efficiency and *vice versa*. In certain circumstances, other back-up pathways, such as microhomology-mediated end-joining (MMEJ)/non-canonical NHEJ or single-strand annealing (SSA) may be implicated in DSB repair^[@CR16]^. MMEJ commonly entails error-prone repair independently of DNA-PK, causing variable-size deletions and inserted nucleotides, whereas SSA generates large deletions^[@CR17],[@CR18]^.

Upon HBV cccDNA cleavage using a single sgRNA, CRISPR/Cas9 systems induce indels in the targeted site^[@CR19],[@CR20]^, while multiplex CRISPR/Cas9 targeting with several HBV-specific sgRNAs results primarily in degradation of HBV cccDNA^[@CR21]^. Although CRISPR/Cas9 are very robust and straightforward gene editing tools, HBV cccDNA targeting with one CRISPR/Cas9 system per infected cell only modestly decreases the cccDNA pool, with over 30% of total cccDNA remaining in the cells 3 weeks after CRISPR/Cas9 transduction, and 10% 5 weeks after^[@CR22]^.Along with strongly suppressing HBV transcription, transfection of CRISPR/Cas9 significantly reduced intracellular HBV DNA and cccDNA levels (Fig. [2g**--**l](#Fig2){ref-type="fig"}). Thus, the CRISPR/Cas9 systems were very effective in cleaving episomal HBV cccDNA and the integrated HBV genome, which transcribes S-RNA independently of the Tet-on system.Figure 2Effects of small molecules 3-aza, L755, B02, and NU7026, and the protein Ad4E1B on HBV replication and CRISPR/Cas9-mediated suppression of HBV in HepG2-1.1merHBV cells. (**a**--**c**) Relative levels of pgRNA, (**d**--**f**) S-RNA, (**g**--**i**) intracellular HBV DNA, and (J-L) cccDNA in HepG2-1.1merHBV cells transfected with CRISPR/Cas9 system and one of the 3 sgRNA (Sp1, Sp2, Sp3), as indicated. Asterisks indicate statistically significant differences. \*p \< 0.05, \*\*p \< 0.01, \*\*\*p \< 0.001, \*\*\*\*p \< 0.0001.

Treatment of transfected cells with 3-aza or L755 consistently enhanced or slightly inhibited CRISPR/Cas9-mediated anti-HBV activity, respectively. Inhibiting HR by B02


---
abstract: 'We present the first numerical computation of the neutral fermion gap, $\Delta_\psi$, in the $\nu=5/2$ quantum Hall state, which is analogous to the energy gap for a Bogoliubov-de Gennes quasiparticle in a superconductor. We find $\Delta_\psi \approx 0.027 \frac{e^2}{\varepsilon \ell_0}$, comparable to the charge gap, and discuss the implications for topological quantum information processing. We also deduce an effective Fermi velocity $v_F$ for neutral fermions from the low-energy spectra for odd numbers of electrons, and thereby obtain a correlation length $\xi_{\psi}={v_F}/\Delta_{\psi} \approx 1.3\, \ell_0$. We comment on the implications of our results for electronic mechanisms of superconductivity more generally.'
author:
- Parsa Bonderson
- 'Adrian E. Feiguin'
- Chetan Nayak
title: 'Numerical Calculation of the Neutral Fermion Gap at $\nu=5/2$'
---

The $\nu=5/2$ fractional quantum Hall state [@Willett87; @Pan99b; @Eisenstein02] has been the subject ofvanish as $e^{-{\Delta_a}/T}$ and $e^{-x/\xi_a}$ and, hence, be negligible.

The smallest gap for charged quasiparticles is usually assumed to correspond to the minimally charged excitations of a state [^1]. For the MR and $\overline{\text{Pf}}$ states, the minimal charge $\pm e/4$ quasiparticles also carry non-Abelian Ising topological charge $\sigma$. It is natural to interpret the gap corresponding to the temperature dependence of the longitudinal resistance, $\rho_{xx}\sim e^{-\Delta_{\rm trans}/2T}$, as the energy gap $\Delta^{\rm qh}_\sigma + \Delta^{\rm qp}_\sigma$ for a charge $\pm e/4$ quasihole-quasiparticle pair, which is thereby deduced from experiments to be $\Delta^{\rm qh}_\sigma + \Delta^{\rm qp}_\sigma
\equiv \Delta_{\rm trans} \approx 0.5$K in the highest-mobility samples [@Choi08]. Numerical studies of small numbers of electrons interacting through Coulomb interactions in the second Landau level find $\Delta^{\rm qh}_\sigma + \Delta^{\rm qp}_\sigma\approx 0.025-0.029\frac{e^2}{\varepsilon\ell_0}$ (which is $3.2-3.7\,$K


#include "File.h"

#include <QString>
#include <QFile>
#include <QFileInfo>
#include <cassert>
#include <cstdlib>
#include <cstring>
#include <string>
#include <utility>

namespace Nav {

File::File(Folder *parent, const QString &path) :
    m_parent(parent), m_path(path), m_loaded(false)
{
}

QString File::path()
{
    return m_path;
}

QString File::title()
{
    QFileInfo fi(m_path);
    return fi.fileName();
}

// 0-based line number.  The offset must be less than the content size.  The
// result will be <= the line count.
int File::lineForOffset(int offset)
{
    ensureLoaded();
    assert(offset < static_cast<int>(m_content.size()));
    int line1 = 0;
    int line2 = lineCount() - 1;
    while (line1 < line2) {
        int midLine = line1 + (line2 - line1) / 2 + 1;
        assert(midLine > line1 &&Menu

Private

A Wagner Matinee part 5

The overture closed, my aunt released my coat sleeve, but she said nothing. She sat staring dully at the orchestra. What, I wondered, did she get from it? She had been a good pianist in her day, I knew, and her musical education had been broader than that of most music teachers of a quarter of a century ago. She had often told me of Mozart`s operas and Meyerbeer`s, and I could remember hearing her sing, years ago, certain melodies of Verdi.

When I had fallen ill, with a fever in her house she used to sit by my cot in the evening when the cool night wind blew in through the faded mosquito netting tacked over the window and I lay watching a certain


in my eyes as well.

It never really dies, then the soul which can suffer so excruciatingly and so interminably; it withers to the outward eye only; like that strange moss which can lie on a dusty shelf half a century, and yet, if placed in water, grow green again. She wept so throughout the development and elaboration of the melody.opposite role. The Zeeman energy reverses the symmetric/antisymmetric pairing due to the crystal field and partially restores magnetic states. $V_1$ is then inversely proportional to $B_z$. For example in the case of Ho with $J=8$ and an $m=\pm8$ ground state in four-fold symmetry, an application of magnetic field results in magnetic states with long lifetimes [@Natterer2017]. This reduces to the situation mentioned above, in which Zener tunneling would induce a step in the hysteresis curve near zero magnetic field. Again, the same effect would be observed for any perturbation proportional to [[$\hat{J}_{z}$]{}]{}. As shown elsewhere [@Karlewski2015] also the coupling to the electron bath can undo singlet formation leading to a doublet of ground states with short lifetimes.

In the second case the field is applied perpendicular to $z$ (in-plane). Such a


& - (2) & 1 (2)\
$C_4$ & - & 1 & - (2) & 1 & - (2) & 1 & - & 1 & - (2) & 1 & - (2) & 1 & - (2) & 1\
$C_6$ & - & 5 & 2 & 3 & 2 & 5 & - & 1 (3) & - (2) & 3 & 2 & 3 & - (2) & 1 (3)\

Higher symmetries
=================

We now analyze the stability of degenerate doublets in other axial symmetries with a $q$-fold rotation axis. We show that these symmetries behave either like $C_q$ or like $C_{2q}$. In the latter case the stability is greatly enhanced — e.g. in a $D_{5d}$-symmetric environment there are 10 classes, so that ground states in a magnetic atom with integerstates are protected by time reversal symmetry, so we expect long lifetimes, unless a magnetic field is applied. The STM experiments showed long lifetimes at zero field that become shorter in small magnetic fields. The energy of an inelastic excitation observed in the experiment, also agrees with the theoretically predicted $J$ multiplet structure.

Interestingly, an ensemble of Ho atoms with time-reversal-protected ground state doublet would also show no magnetic hysteresis under the experimental conditions of the XMCD measurements ($T=\SI{2.5}{\kelvin}$, $\approx\SI{10}{\second}$ per point). At zero field the average magnetization of Ho atoms is zero, as the two stable magnetization orientations are equally probable. The application of a magnetic field along $z$ splits the doublet, introducing a preferential orientation, while at the same time increasing the switching rate quadratically, leading to


low fields and a thermal population of the nuclear spin states, the nuclear spins may be treated as a simple heat bath in analogy to the electron heat bath. When taking the lowest order interaction of the electronic total angular momentum $J$ with the nuclear spin $I$ of the form $A{\boldsymbol{I}}{\boldsymbol{J}}$, the selection rules are identical to electron scattering not qualitatively changing magnetic stability. Only, if simultaneous spin flips of a conduction electron and a nuclear spin are considered, the rules for elastic magnetization reversal change and stability can only be sustained for protection of at least second order. The difference between a theoretically stable and theoretically unstable system can however make a decisive difference in the lifetime of the magnetic state.

The considerations above would limit the lifetimeQ:

Javascript: Open new window and send the result back to parent window

On many pages you can log in with google. When you click the button, a new window is opened where you can enter your e-mail and password. After successful login the window closes automatically and the old window receives the login token. How does this technically work? How is the result from the google login window send to the old window?
Thank you

A:

There is a relationship between the browser windows that is maintained. In the child window (the popup), for instance, you can send a message to the window that created it
window.opener.postMessage("a message");

How this is implemented can vary, but the basic answer to your question is that your browser is just keeping track of the windows relationship and


Q:

Secondary IP (eth0:0) acts like main server IP

I have a CentOS server, configured with 4 consecutive IPs:
eth0   5.x.x.251
eth0:0 5.x.x.252
eth0:1 5.x.x.253
eth0:2 5.x.x.254
The problem is that all traffic goes out to the internet with eth0:0 (5.x.x.252) as the source IP, instead of eth0.
# curl ifconfig.me
5.x.x.252
How can I fix this, so that all traffic goes out via eth0, ie my main IP?
PS: My server is VPS running on a Xen dom0, the latter being configured in routed mode networking.
Thanks in advance!
Server configuration
# ifconfig
eth0      Link encap:Ethernet  HWaddr 00:x:x:x:x:AE
          inet addr:5.x.x.251  Bcast:5.x.x.255  Mask:255.255.255.255
          inet6 addr: fe80::x:x:x:x/64 Scope:Link
   incarceration rate, even though per capita, the crime rate amongst both racial groups is similar.

Ms. Oluo then attempts to justify that racist conduct of hipsters doesn’t make them racist because they claim ignorance, therefore cannot be called racist. Nothing epitomizes a text book example of entitled white privilege more than this pathetic excuse. It’s as ridiculous as claiming rape is acceptable because the perpetrator didn’t know it was wrong. Her attempt to separate racists from their racist conduct, while well-intentioned, is ill-conceived. When someone commits rape, we call them a rapist. When someone acts in a racially discriminatory manner…we rightly call them racists.

While I agree with her that people of color face passive and institutional racism on a daily basis, by attempting to allow racists to avoid responsibility


Q:

"The DOM/scripting bridge is disabled" error in Blend

I've been given a custom Silverlight control to use, and everytime I open it up in Blend, get the "The DOM/scripting bridge is disabled" error.
Looking in the control's source code, I can see calls to
public override void OnApplyTemplate()
    {
           ...
   HtmlPage.Window.Invoke("GetPrimaryGradStart").ToString()

which I'm guessing might be the problem. Any ideas about what I can do, or am I back to pure XAML?
cheers
Toby

A:

usually (i.e. when a Silverlight app is embedded in an HTML page) one has to set the "enablehtmlaccess" parameter to true for the app via HTML or JavaScript, because otherwise calls like HtmlPage.Window.Invoke are not allowed (and throw an exception).
So I guess the problem is thatprotests demand resignation of president Thousands of demonstrators took to the streets of Seoul on Saturday, demanding the ouster of Park Geun-hye amid an escalating corruption and influence-peddling scandal. Many South Koreans are angry after it emerged this week that a long-time friend to the country’s leader had been given access to confidential government documents, including first drafts of policy speeches, and allegedly used her links to the presidency for financial gain. (FT)

Taiwan may pass first Asian same-sex marriage law President Tsai Ing-wen on Saturday voiced support for same-sex marriage, significantly boosting the chances of the island becoming the first in Asia to champion marriage equality. (NAR)

A pirate’s life for Iceland The island nation’s prime minister resigned on Sunday after the anti-establishment Pirate Party rode a wave of


components. In addition, the PWB often includes metal areas serving as heat sinks for high power or thermally sensitive components. As the use of integrated circuits has grown, the higher density of interconnections has necessitated double-sided PWB's in which additional interconnections are made employing conductor patterns on the other side of the board. This trend has been extended to boards of many layers of interconnections termed multilayer PWB's. Connections from layer to layer are typically made by plated through holes.
Conductor patterns are typically formed by photoetching a copper foil clad epoxy fiberglass substrate. A photoresist layer is applied to the copper foil and patterned by exposure to ultraviolet light through a stencil-like film artwork mask. Areas exposed on the photoresist are polymerized. The unpolymerized areas are removed bystories claiming DiCaprio went through utter hell and back to make it. It’s gruelling, but worth watching.Spotlight
As this came right at the start of 2016 it almost slipped off my list. Not flashy nor showy, but a well-told tale making archive researching seem as engaging as it can.High-Rise
I’m starting to think I can only take Ben Wheatley films in small doses. They’re way too stylised and I just don’t get them. That said, this film is insanity in a good way. And it’s Hiddleston as you’ve never seen him before.

TO WATCH LIST

Everybody Wants Some!!
Hell or High Water
Hail, Ceasar!
American Honey
Paterson
The Nice Guys
Hunt for the Wilderpeople
Kubo and the Two Strings
Midnight Special
Sausage Party
Green Room
The Big Short
The Hateful Eight
The Girl With All The Gifts
Victoria
Arrival

PROPER TURKEYS
Maybe it’s mean calling these turkeys, but they


Secretion of glucagon-like peptide-1 and reactive hypoglycemia after partial gastrectomy.
Glucagon-like peptide-1 is a peptide hormone from the distal small intestine which stimulates insulin secretion and inhibits glucagon secretion and thereby lowers blood glucose. This hormone, therefore, could be involved in the pathogenesis of postprandial reactive hypoglycemia. We subjected 8 patients showing symptoms of early dumping after partial gastrectomy to an oral 100 g glucose load and measured blood glucose and plasma insulin, C-peptide, glucagon, enteroglucagon and GLP-1 concentrations for 3.5 h after ingestion. Ten matched controls were treated similarly. The patients had higher blood glucose concentrations for the initial 60 min, but lower values for the remaining test period with a nadir of 2.76 +/- 0.19 mmol/l at 146 +/- 17 min after glucose (controls: 3.36 +/- 0.21of Soviet communism, protecting democracies in Europe and around the world and helped create the conditions necessary for the emergence of the European Union and other multilateral institutions that would preserve the peace and promote prosperity.

Today, in an era of great power competition, we face global threats that require our continued collaboration:

Renewed Russian aggression, seizing territory in a clear breach of international norms and conventions, and its use of disinformation to
sow discord, meddle in elections, and attempt to fracture our democracies;

Violent extremists who resort to terrorism as a means to pursue corrosive ideologies and instill fear;

Malign activities and dangerous nuclear ambitions on the part of those who would do us harm, including Iran and North Korea; and

An assertive China that seeks military and economic advantage by flouting established


so wrongheaded, it’s tough to decide where to begin.

In reality, what Sessions has done is return the Justice Department to the traditional guidance articulated nearly four decades ago by President Carter’s highly regarded attorney general, Benjamin Civiletti (and memorialized in the U.S. Attorney’s Manual). It instructs prosecutors to charge the most serious, readily provable offense under the circumstances. Doesn’t work? This directive, in effect with little variation until the Obama years, is one of several factors that contributed to historic decreases in crime. When bad guys are prosecuted and incarcerated, they are not preying on our communities.

The thrust of the policy Sessions has revived is respect for the Constitution’s bedrock separation-of-powers principle. It requires faithful execution of laws enacted by Congress.

A concrete example makes the point. Congress hasdrug transactions pursuant to 21 U.S.C. § 881. As succinctly summarized by the First Circuit in Giraldo, supra:
These laws provide that property worth $500,000 or less is subject to administrative forfeiture without judicial involvement. 19 U.S.C. § 1607. The administrative process requires the government to publish notice of its intent to forfeit the property once a week for three weeks and to send written notice to any party known to have an interest in the property. Id. § 1607(a); 21 C.F.R. § 1316.75. A claimant then has 20 days after the first publication to file a claim and a cost bond of not less than $250. The filing of the claim and the bond stops the administrative process and requires the seizing agency to hand the matter over


the government is incarcerating or prosecuting the property owner when it elects to impose the additional burden of defending a forfeiture proceeding, fundamental fairness surely requires that either the defendant or his counsel receive actual notice of the agency's intent to forfeit in time to decide whether to compel the agency to proceed by judicial condemnation.
Woodall, 12 F.3d at 794-95 (citations omitted); accord Giraldo, 45 F.3d at 511 (where claimant is residing at place of government's choosing, such as in prison, government "must take steps to locate the claimant in order to satisfy due process."); cf. Robinson v. Hanrahan, 409 U.S. 38, 40, 93 S.Ct. 30, 31-32, 34 L.Ed.2d 47 (1972) (per curiam). Here, petitioners have made a colorable claim that the government knew of Ronald Vance's locationsort of interest in the boat held by William Vance. Accordingly, the government was required to use reasonable efforts to provide written notice to William Vance as required by § 1607(a). Because the government admittedly failed to do so, the Court has jurisdiction to consider the underlying merits of William Vance's challenge to the forfeiture.[4]

*954 D. Adjudication of the Merits

Having concluded that the Court has jurisdiction to consider petitioner William Vance's claims, it is appropriate to consider the other arguments raised by the government in opposition to petitioners' motion. Because, as indicated above, it is appropriate to construe petitioners' motion as a civil complaint, it is equally appropriate to treat the government's response as a motion for summary judgment pursuant to Fed.R.Civ.P. 56(c). Under Rule 56(c), summary judgment


favorable to the nonmovant as well as draw all reasonable inferences in the non-movant's favor. See United States v. Diebold, Inc., 369 U.S. 654, 655, 82 S.Ct. 993, 994, 8 L.Ed.2d 176 (1962); Bender v. Southland Corp., 749 F.2d 1205, 1210-11 (6th Cir.1984).

1. William Vance's Standing to Challenge the Seizure and Forfeiture

The government first contends that William Vance lacks standing to challenge the forfeiture because he cannot show that he is entitled to "lawful possession" of the boat. "[C]ourts have held that an allegation of ownership and some evidence of ownership are together sufficient to establish standing to contest a civil forfeiture." Torres v. $36,256.80 U.S. Currency, 25 F.3d 1154, 1158 (2d Cir.1994); accord United States v. $38,570 U.S. Currency, 950 F.2d 1108, 1113 (5th Cir. 1992) ("aSix-Year Limitations Period to Petitioners' Claim
As § 2401(a) requires, in order to satisfy the jurisdictional requirement imposed by the statute, petitioners' must have brought their action within six years of the date their right of action "accrued." 28 U.S.C. § 2401(a). The Court need not decide, however, precisely when petitioners' right of action accrued. The earliest date on which it could be argued that petitioners' right of action accrued is the date of the actual seizure of the boat in December, 1990. Petitioners filed their motion for return of property on July 15, 1996. Accordingly, whether the petitioners' right of action accrued at the time of seizure, forfeiture, or at some other time thereafter, petitioners have satisfied the six-year limitations period of § 2401(a). Accordingly, the statute of


“The College Counseling Office will not answer phone calls from blocked numbers.”

AD

“The College Counseling Office will not open any mail without a recognizable return address.”

AD

“If a parent ever feels the need to inform me or my colleagues regarding the actions of a child that is not their own — I will ask you to leave my office or end the phone conversation.”

The message seemed to confirm the vague rumors that had circulated for weeks — murmurs about parents behaving badly, even going so far as to disparage other students, presumably to give their own teens a leg up in the high-stakes college admissions competition.

The intense pressure surrounding the admissions process — and the corrosive effect it can have on a parent’s tether to reality and morality — hassome parents are guiding their students to not reveal where they’re applying, to not talk about college visits, or not share information about summer programs or opportunities that might help other kids be stronger applicants,” he said. “I think that sends damaging messages to young people about individualism versus commitment to others.”

Ned Johnson, founder of D.C.-based tutoring service PrepMatters, is familiar with this phenomenon. Years ago, he asked the parent of one of the students he was coaching for an introduction to the teen’s school counselor, “because things generally work better when I’m on the same page with the child’s school,” he said.

AD

The mother said she’d be happy to make the introduction — but only after her younger child had graduated from high school. “She said, ‘I don’t


echoed in the follow-up email sent to Sidwell’s senior parents as they prepared to begin the year their children will graduate and head off to college.

“In this new year, I hope we will reaffirm our commitment to the well-being of our students and to the common good,” Garman wrote. “I hope that we will recommit to helping children understand that college is merely the next destination on a lifelong journey, not their destiny.”Herman Cain Takes on the First Amendment

GOP Presidential candidate Herman Cain has an Islam problem. The former Godfather's pizza godfather put his foot in his mouth early in his campaign when he told Think Progress he wouldn't appoint any Muslims in his administration (which would be unconstitutional), and again when he said Rep. Keith Ellison (D-Minn.) wasn't loyal to the Constitution because he's Muslim, and again when he said he has never encountered an American Muslim who is loyal to the Constitution, and then again when he denied ever saying any of those things and blamed the media.

Now he's given up on walking back his statements and returned to his roots. On Thursday, Cain made a campaign stop in Murfreesboro, Tennessee, the Nashville satelite that's become a ground


zero for the anti-Islam jihad. At the center of the controversy is the Islamic Center of Murfreesboro, a local mosque that has been trying to expand its facilities. Opponents have alleged that the the mosque is secretly waging a (very, very) stealth jihad against the people of Middle Tennessee. The construction site has been subjected to arson, and the project itself was challenged in court by opponents who argued that Islam is not a religion and therefore is not entitled to First Amendment protections (The Justice Department said otherwise). Cain, evidently, agrees with the Murfreesboro anti-mosque activists:

Cain didn't bring up the controversial facility in a campaign rally on Thursday, but told reporters afterward that he's concerned about the Islamic Center of Murfreesboro.

"It is an infringement and an abusehow to win. Take Los Angeles to win its division.

No. 2 Anaheim Ducks

2012-13 results: 30-12-6, lost in first round

Story line: Ducks are married for life to Ryan Getzlaf and Corey Perry

Goaltending: Jonas Hiller (15-6-4, 2.36, .913), Viktor Fasth (15-6-2, 2.18, .921). The net probably will belong to Hiller to start the season, but there will be periods when Fasth looks like No. 1.

Analysis: The Ducks were able to sign Getzlaf and Perry to eight-year extensions when the prevailing wisdom was they probably could keep only one. Those signings caused salary-cap woes, and Bobby Ryan was a casualty. The Ducks are locked into the Getzlaf-Perry combo as the centerpiece of their offense for years to come. Secondary scoring also allowed Anaheim to rise last season. Andrew Cogliano, Daniel Winnik,


Cost of removing signs? No charge

A Pasco County man learns he won't be prosecuted for plucking illegal signs from the ground.

By David DeCamp, Times Staff Writer
Published December 17, 2007

HOLIDAY - What forces were not lined up against Gary Thomas? He faced the Sheriff's Office, prosecutors, county bosses and neighbors. Some Realtors and perhaps misdirected garage sale patrons.

All because he hated homemade signs so much that he snatched dozens of them on weekends in his Holiday neighborhood, insisting that it is illegal to put them on public property. If you plopped, say, a garage sale sign in what he considered the wrong place - poof! The sign would disappear.

Put off by Thomas' persistent raids, authorities charged him with petty theft in April.

When the St. Petersburg Times told his storyIdzik's professional character or his personality to act this way? Until proven otherwise...I'd have to say no.

And I don't think an OC like Mornhinweg, is coming to the Jets being told...or is under the impression...that he's nothing more then 2013 OC fodder. Right now...the Jets need to re-establish some kind of credibility among the coaching establishment. After dumping Schotty Jr., and then doing a one and done with Sparano...as OCs NYJ. To then follow this up with another bunch of firings...well it better be definitely based clearly to all...on merit. that's how I see it.

Realistically...Jets will have another year of misery and losing. Everyone knows this. If Rex and the CS get canned...it won't be based on mere losses. It would have to do with how they handle


why I hope that what Woody believes will work...will actually work! Or else...it's simply another round of cockeyed optimism with another bunch of saviors...as it always is...in Jets Paradise.

Many here fail to realize...that when Woody set out to search for a new GM NYJ, that he sincerely wanted this individual to work with Rex, to turn the Jets around into being a playoff contender again. This was not a hollow request by Woody. He's not envisioning Rex as automatic HC fodder for 2013 only. But as a still viable part of the Jets formula to attain a Lombardi Trophy. This should be common sense to anyone posting here in this thread.

Woody is not interested in ridding himself of a HC that got the Jets to two consecutive AFCCGs.never once shown any interest in offense, the most important part of the game. He is a defensive coordinator.

Unless he changes drastically, I see similar results in 2013 and he will be fired. So where does that leave us?

I feel like right now the Jets are one year away from being three years away, if that makes sense.

Hey look at that, a well thought out, easy to read post. That doesn't happen much around here anymore.

I have a very bad taste in my mouth from this year and keeping Rex is one of the most mind boggling decisions I've seen a football team make in a long time.

He has done nothing the last two years to deserve this job. I'm not going to list everything again... I just


shenanigans...to knock Idzik off course from what he wants to accomplish.

All I wanted this Xmas...was a qualified and capable new GM for the NYJ. The package starts opening...in this Thursday's presser. I hope I'm pleased with what's inside it.

Very well thought out post, considering it is a view taken from outside the organization.

I would just like to add, that in the last ten years, when great things were expected from the Jets they seem to disappoint. Yet, when nothing was expected they surprised the hell out of a lot of folks.
There are many things to correct and it's only Jan, I will hold off making any kind of predictions until after I see how it all comes together. I find it hard to write off a whole seasonreflect Ryan's personality according to Rex.

At the end of the day, It's about the direction and getting the right talent to fit that direction. Hiring Marty Mornhinweg and David Lee fits the idea of having a big play and unpredictable offense. Marty is excellent with QB's and his offense is QB friendly. He needs the right guy to execute it. Until proven otherwise, Mark Sanchez isn't the right guy. The Jets have no game breakers right now on offense. That can change for the better. It's up to the scouting department and the GM to get them. On defense, The Jets have a great young d-line and an excellent trio of corners. They still need better team speed and a dynamic play maker in the front 7 preferably


John Idzik. At the same time, The Jets have the same football leader in place in Rex Ryan, the same quality defensive system and a whole new accomplished offensive staff. Rex is coaching for his life in 2013. If the Jets do not have a winning season or make the playoffs. He is gone. He knows it and the entire organization knows it. Rather than begin a complete organizational reset. Woody Johnson has decided to try and take another shot. The problem is that The Jets are not constructed properly to be a legitimate contender. They do not and will not have the neccessary cap room to improve their talent base. They don't have the current talent base to be a legitimate contender. The team is stuck inperhaps some interaction like chemotaxis. Studies with some bacteria strains have reported a wide variety of complex pattern formation, in most cases due to competition for food resources and chemical interaction. With uniform, not-exhaustible background of nutrients and without the presence of mutations and chemical signaling, these simple strains are suppose to invade a region of nutrient rich agar in the form of a front propagating with some typical velocity, known as the Fisher front [@murray; @fisher; @kpp].

Biological problems of colony growth in *inhomogeneous* environment and under forced convection has been modeled recently by Nelson and Shnerb [@ns] and by Dahmen, Nelson and Shnerb [@dns]. These studies have focused on the spectral properties of the linearized evolution operator, which becomes non-Hermitian in the presence of convection [@hn]. An


the moving environment fails as the drift is faster than the Fisher front velocity, and in this case the colony lags behind the shelter and an extinction transition takes place.

In order to get the essence of the theory, let us consider a one-dimensional example, where bacteria are diffusing on a line parametrized by $ x $, and are subject to some environmental heterogeneity which implies fluctuating growth rate. If the bacteria diffuses, multiply and are forced to migrate with some convection velocity $ v $, the differential equation which describes the evolution of the colony is,

$$\label{1}
\frac{\partial c}{\partial t}=D\frac{\partial ^{2}c}{\partial x^{2}}+v\cdot \frac{\partial c}{\partial x}+a(x)c-bc^{2}.$$

where $ a(x) $ is the local growth rate. When the hostile environment outside the “oasis” causes the immediate death of any bacteria, and inside theand the azimuthal degrees of freedom, and the spectrum becomes “chaotic” when convection takes place. The results for this case are, accordingly, relevant also to the more complicated geometry of the experiment.

The basic equation for the bacterial growth problem on a non-uniform substrate, in the absence of mutation and chemical interactions, is [@ns]:

$$\label{5}
\frac{\partial c(\bf {x},t)}{\partial t}=D\nabla ^{2}c(\bf {x},t)+a(\bf {x})c(\bf {x},t)+v\cdot \nabla c-bc^{2}.$$

With no convection and homogeneous, positive $ a $ this equation supports Fisher front propagation with velocity $ 2\sqrt{Da} $. The experimental situation corresponds to $ D\sim 10^{-6}cm^{2}/s $ and $ a\sim 10^{-3}/s $. The Fisher velocity is of order $ 0.1-1\mu m/s $, as has been found experimentally. The Fisher *width*, which is the characteristic scale of spatial correlations in their system, is $ \sqrt{D/a}\sim 10^{-2}cm


are the local growth rate, and for any finite matrix, by adding an appropriate multiplication of the unit matrix, one may get a positive semi-definite matrix with the *same* eigenvectors. Perron-Frobenius theorem [@perron] then implies that ground state should be a nodeless, positive eigenvector. There is a simple physical interpretation to this result: since the ground state dominates the system at long times, and the number of bacteria should not become negative, Perron-Frobenius theorem should hold. Diagonalizing numerically the evolution operator, one may get a ground state with nodes, which is physically impossible.

=7.0cm

=7.0cm

=7.0cm

=7.7cm

=7.7cm

=7.7cm

In order to solve this problem one should carefully take the discrete limit of the continuum theory. For our case, as $ \theta  $ is discretized to quanta of $ \Delta \theta  $, theinequilebration.

I wish to thank A. Kudrolli, D. R. Nelson and K. Dahmen for helpful discussions and comments.

E. Ben-Jacob et al., Nature **368,** 46 (1994). J.-I. Wakita et al., J. Phys. Soc. Japan **63**, 1205 (1994). E. O. Budrene and H. C. Berg, Nature **376**, 49 (1995). T. Neicu, A. Pradhan, D. A. Larochelle and A. Kudrolli, cond-mat/0001023, Phys Rev. [**E**]{} (in press). J. D. Murray, Mathematical Biology (Springer-Verlag, New York, 1993). R. A. Fisher, Ann. Eugenics **7**, 353 (1937). A. Kolmogoroff, I. Petrovsky and N. Piscounoff, Moscow Univ. Bull. Math. **1**, 1 (1937). D. R. Nelson and N. M. Shnerb, Phys. Rev. **E 58** 1383 (1998). K. A. Dahmen, D. R. Nelson and N. M. Shnerb, cond-mat/9807394 (Jour. of Mathematical Biology, in press). See also: N. Hatano and


is a wonderful development
of the induction coil destined to be of great importance."

Electrical Review, commenting upon the wireless : "Mr. Tesla's
researches in this field have attracted world-wide attention, and
his is undoubtedly the master mind."

Der Electro-Technische Anzeiger, Berlin, and Elektrizitat, Leipzig,
Germany, (commenting upon Tesla's work) : "It is a combination of
the grandest power of technical performance with the most vivid
imagination, such as has never before manifested itself in the
human mind."

Brigadier Allen, of the United States War Department Commenting
upon Tesla's Turbine): "Something new in the world. Officers are
greatly impressed with it."

While studying abroad I read every scrap of his work I could lay my
hands on. I performed most of his high frequency experiments, and
the more I saw of his work the more imprest I became.

Some years ago as Editor ofnow adopted and
published in text books and technical works:

The other night the Editors of the "Experimenter had the
opportunity of passing an evening with Tesla. We talked about many
things, so interesting, that I will reserve them for another
article - but mostly, of course, the conversation centered about
Tesla himself.

"Dr. Tesla," I said to him, "you are aware of our great admiration
for you, which may or may not be important. But the great public
knows little of your mark. Even many of those technically educated
- excuse the frankness - think that you are either a dreamer or,
worse yet, crazy.

The fact is the world does not understand you because you live in
the next century. Moses was a great man, but the Bible teaches us
that he was "heavy of tongue" and could not make


The Bush Administration and its media lapdogs

The Bush Administration and its media lapdogs

The traditional media never have gotten this one right, and they're certainly not going to now. Not today. Probably not ever. They reported the facts as they happened, but tying them all together is beyond their ability, interest and/or intent. Tying together the facts that they themselves reported.

I've posted this many times, in many forms. This is a cut-and-paste from a previous post, and no doubt I will need to post it again. The Bush Administration failed on so many fronts, from crashing the economy to ignoring climate change to allowing the people of a great American city to be devastated by a natural disaster for which there was plenty of time to be prepared, tothe enemy hard and most of the victory objectives is under my control. They are counterattacking in mass and the KG digs in.

On my right flank I have deployed three STUG III on some dirt roads close to some houses at the outskirts of a small village. There is about 150-200m of open terrain before a treeline cuts the LOS with light wood behind it. The Stugs I thought would be out of the battle acting as a reserve. A fourth Stug is a few hundred meters back inside the village if anything was to happen.

Suddenly to my surprise, this far down T-34/85's suddenly roll out of the trees trying to outflank my KG and rolls directly in to my Stugs who takes them on. Fire is exchanged


parameter space which satisfies all the current experimental constraints, and present a concrete benchmark point. This kind of models not only preserves the merits of pre-LHC SSMs such as naturalness, dark matter, etc, but also solves the possible problems in the SSMs with Dirac gauginos due to the $F$-term gravity mediation.'
author:
- Ran Ding
- Tianjun Li
- Florian Staub
- Chi Tian
- Bin Zhu
bibliography:
- 'DiracTMSSM.bib'
title: 'The Supersymmetric Standard Models with a Pseudo-Dirac Gluino from Hybrid $F-$ and $D-$Term Supersymmetry Breakings '
---

CERN-PH-TH-2015-029

[**Introduction**]{}—It is well-known that the weak scale supersymmetry (SUSY) is the most promising extension for physics beyond the Standard Model (SM) [@Martin:1997ns]. It provides a well-motivated and complete framework to understand the basic questions of TeV-scale physics: the gauge hierarchy problem is solved naturally, the lightest supersymmetric particle (LSP) such as neutralinoTeV, which is obviously an simple modification to the SSMs before the LHC. Also, such a heavy gluino will not induce the electroweak fine-tuning problem if it is (pseudo-)Dirac like the supersoft SUSY. However, there exists some problems for supersoft SUSY with Dirac gauginos: $\mu$ problem can not be solved via the Giudice-Masiero (GM) mechanism [@Giudice:1988yz], the D-term contribution to the Higgs quartic coupling vanishes, the right-handed slepton may be the LSP, and the scalar components of the adjoint chiral superfields might be tachyonic and then break the SM gauge symmetry, etc [@Fox:2002bu]. The first three problems can be solved in the $F-$term gravity mediation, while the last problem was solved recently [@Nelson:2015cea]. Therefore, we will propose the SSMs with a pseudo-Dirac gluino from hybrid $F-$ and $D-$term SUSY breakings. To


and \[tab:Db=4\], respectively. We will study the model with $\Delta b=3$ elsewhere (For Dirac gaugino case, see Ref. [@Benakli:2014cia].). Here, we shall consider the model with $\Delta b=4$. In this model, the $SU(2)_L\times U(1)_Y$ Dirac gaugino masses are forbidden, and the neutrino masses and mixings can be generated via Type II seesaw mechanism [@Konetschny:1977bn]. From the string model building point of view, we usually do not have the vector-like particles $T_+$ and $T_-$ since they arise from an symmetric $\mathbf{15}$ representation of $SU(5)$. Interestingly, the symmetric $\mathbf{15}$ representation of $SU(5)$ or flipped $SU(5)$ can indeed be obtained in the Type IIA orientifold on $\mathbf{T^6/(Z_2\times Z_2)}$ with intersecting D6-branes [@Cvetic:2002pj; @Chen:2006ip]. The alternative way to get $T_+$ and $T_-$ is to embed $SU(2)_L$ into a diagonal gauge group of $SU(2)_A\times SU(2)_B$, whichin the heterotic string compactification [@Cvetic:1998gv], the Fayet-Iliopoulos term is given by $$\begin{aligned}
\xi = {g_X^2{\rm Tr}{ q^X} \over 384\pi^2}M_{\rm Pl}^2\, ,\end{aligned}$$ where $M_{\rm Pl}$ is the reduced Planck scale.

To achieve gravity mediation, we consider the following superpotential from the instanton effect which breaks $U(1)_X$ $$\begin{aligned}
W_{\rm Instanton} &=& M_I S S'~.~\end{aligned}$$ This is the key difference between our scenario and that in Ref. [@Dvali:1996rj] where the superpotential is $U(1)_X$ invariant and then one can not realize the traditional gravity mediation. Minimizing the potential, we obtain $$\begin{aligned}
&& \langle S \rangle = 0~,~~\langle S' \rangle^2
= \xi- {M_I^2 /g_X^2}~,~~ \langle F_{S'}\rangle = 0~,~\\
&& \langle F_{S}\rangle = M_I\sqrt{\xi- {M_I^2 /g_X^2}}~,~~
 \langle D\rangle ={M_I^2}/{g_X^2}\, .\end{aligned}$$ Because $S$ is neutral under $U(1)_X$, the traditional gravity mediation can be realized via the non-zero $F_S$. The Dirac mass for


of $T_{+/-}$ and $\Phi$ are about 5.1 times larger than the gravity mediation via $F_S$. This case may be realized in Type IIA/B compactifications with the D-branes wrapping the large cycles but not in the heterotic string compactifications since $g_X$ is small. (ii) We choose $M_I=1.25\times 10^5~{\rm GeV}$, ${\rm Tr} q^X=2$, and $g_X=0.8$, which may be realized in heterotic string as well. So we have $D=2.44\times 10^{10}~{\rm GeV}^2$ and $F_S=5.5\times 10^{21}~{\rm GeV}^2$. Thus, we need the effective messenger scale $M_*$ around $10^6$ GeV to realize the relatively heavy masses for Dirac gluino and scalar components of $T_{+/-}$ and $\Phi$. In our model, the vector-like particles like $XD^c/XD$ can be messengers.

   $\tan\beta$   $\lambda_{\text{eff}}$     $\mu$        $B_\mu$             // richTextBoxMessage
                //
                richTextBoxMessage.Anchor = (((AnchorStyles.Top | AnchorStyles.Bottom)
                | AnchorStyles.Left)
                | AnchorStyles.Right);
                richTextBoxMessage.BorderStyle = BorderStyle.None;
                richTextBoxMessage.DataBindings.Add(new Binding("Text", FlexibleMessageBoxFormBindingSource, "MessageText", true, DataSourceUpdateMode.OnPropertyChanged));


};
            static readonly String[] BUTTON_TEXTS_ENGLISH_EN = { "OK", "Cancel", "&Yes", "&No", "&Abort", "&Retry", "&Ignore" }; //Note: This is also the fallback language
            static readonly String[] BUTTON_TEXTS_GERMAN_DE = { "OK", "Abbrechen", "&Ja", "&Nein", "&Abbrechen", "&Wiederholen", "&Ignorieren" };
            static readonly String[] BUTTON_TEXTS_SPANISH_ES = { "Aceptar", "Cancelar", "&Sí", "&No", "&Abortar", "&Reintentar", "&Ignorar" };
            static readonly String[] BUTTON_TEXTS_ITALIAN_IT = { "OK", "Annulla", "&Sì", "&No", "&Interrompi", "&Riprova", "&Ignora" };

            #endregion

        City of Ferndale Police Department

Emergency Calls Only: 911 or 786-4225

Non-Emergency Calls: 786-4025
600 Berding St.
Ferndale, CA 95536

Police Chief: Bret Smith

The Victorian Village of Ferndale and the surrounding western Eel River
valley share a blending of neighborhood and self-reliance. The small-town
character, together with the isolated setting encourage a kinship of folks
passionate about their homes and lives, actively involved in the social and
economic fabric of their community.

The Ferndale Police Department recognizes the community of Ferndale to be
unique in its heritage. We respect its past and special sense of place,
while working toward its future.

The members of the Ferndale Police Department accept the responsibility for
the protection and safety of our community. We value honesty and integrity
and are dedicated to defending the constitutional rights of our citizens,
operating on the basis of respect and equality for


Advantages

Disadvantages

Decent read

Steven Spielberg: A Biography was written by Joseph McBride and first published in 1993 before being updated in 2011. Spielberg is the most famous film director in the world but always seems like a slightly vague character in real life (Woody Allen, for example, is notoriously private but I feel like I've heard Allen talk about his own life and work far more than Spielberg) so makes an interesting subject for a biography I think. He was the youngest director to ever be given a contract by a major studio and is responsible for some of the highest grossing films of all time (Jaws, Indiana Jones, E.T, Close Encounters of the Third Kind, Jurassic Park). As he got older, Spielberg started to make more dramatic films likeanything he wanted to. I love reading about Jaws and McBride is very good when it comes to the film stuff. Much better than someone like John Baxter for example. Jaws was an adaptation of a potboiler thriller novel by Peter Benchley and wasn't really expected to be the huge success that it became. The shoot was incredibly troubled and went over schedule and over budget - mostly because the mechanical shark they were given kept conking out and frequently proved to be useless. Spielberg took to calling the mechanical contraption "the giant turd" during the aquatic sequences and had his hands full trying to get any footage at all that looked good. It was remarkable really that with all these problems and his tender age he managed


and tales from the filming of Jaws right through to Jurassic Park. One good paragraph is about filming of Close Encounters and getting the young boy actor to look in awe as the space ship light floods through the lonely farmhouse. When the dirty oak door finally opens, the youngster doesn’t see an alien, but director Spielberg and co-director aping around in monkey suits to induce that wondrous smile. The biog also teaches you a lot on how the film studios and business work as well as giving you an excellent privileged insight into an extroidanary man. I personally think he’s the best there ever was and this book takes you into that mythical world. It’s a nice solid read that would suit movie buffs and dreamers alikewell.

This clip of Cormier marking out over Seth Rollins winning the WWE Championship at WrestleMania 31 in 2015 is a classic.

Here are some other clips of Cormier talking about wrestling including a long chat on the Edge and Christian podcast.

Find us on Facebook

Search our Archives

Archives

Archives

CHECK OUT OUR TSHIRTS

Take a look at our TJRWrestling shirts at prowrestlingtees.com/tjrwrestling. If you’ve ever wanted to do something to support the website, getting a shirt would be a good way of doing it! Also, check out the graphic below to see what they look like.


Q:

Kernel driver check if memory is mapped (BugCheck 0xC2)

This seems like such a simple issue but I cannot find an elegant solution. I've traced my driver down to a call to MmUnmapIoSpace, which produces a BugCheck 0xC2 {7,,,} message.
Is there a way to test if a particular area is mapped within a windows driver before calling MmUnmapIoSpace? I've checked if the pointer is NULL but it doesn't seem to be working.
I don't seem to see any documented/undocumented functions to test whether or not a call to MmUnmapIoSpace will produce a 0xC2 bugcheck.
Any fool-proof way to test this without holding a bunch of booleans or the like?

A:

No, there is no function to check. Instead, I just wrapped the pointer in a struct which held a boolean that indicated ifbefore the election about accepting the
results as Democracy?

...What happened is that the people that said this expected to win the
election..but didn't.

It really shows me that most people are phonies and they only believe in their
own self-interests. The founding fathers were brilliant when they designed the
electoral college. It stopped a criminal from becoming president.

You would think that the Democrats would learn from their mistakes. Rather
than being bigoted, painting all opposing viewpoints with the same brush
(while expecting more acceptance in return), and censoring free speech, you
need to figure out why people voted for Trump.

Otherwise, we will have a 2-term president with no Democrats in sight for many
years.

edit: The downvotes proves my point. Thanks! :-)

~~~
sctb
This account has been posting primarily political and ideological comments.
This site is for civil discussion about topics


on the web (that I've seen at least).  It also adds to the complexity of the domain models when I am not sure it is needed.
Another example is wanting to make sure that a Name is only used by one product.  Would this go in the Product class, ProductRepository Add() method, or where?
As a side note, I plan to use NHibernate as my ORM however, to accomplish what I want it (theoretically) shouldn't matter what ORM I am using since TDD should be able to isolate it all.
Thanks in advance!

A:

I usually approach this by using a layered architecture. How to do this? You basically have the following (ideally) VS projects:

Presentation layer (where the UI stuff resides)
Business layer (where the actual business logic resides)
Data access layer (wherePrairie schooner

Prairie schooner may refer to:
 Covered wagon used by pioneers in the American old west
Prairie Schooner, a magazine published by the University of Nebraska-Lincoln
Prairie Schooner Book Prize
Prairie Schooners, a 1940 American western film directed by Sam Nelson

See also

Conestoga wagon


the Kurgan hypothesis, these speakers of the ancient Proto-Indo-European language emerged from the Pontic-Caspian steppes some 6-8,000 years ago. This was fairly close to modern Ukrainian borders, and might even have included parts of eastern Ukraine.
Subsequently, the Proto-Indo-Europeans dispersed throughout Eurasia in a series of migrations (probably intermarrying with existing locals as they went). By about 1,000 B.C., the Proto-Indo-Europeans have spread from their Urheimat to much of Europe as well as Iran and India, which matches what your teacher says. Wikipedia has a map charting these movements:

Naturally, these early Indo-Europeans carried their culture with them as they moved, including religion. The ancient Proto-Indo-European pantheon developed into Greek, Roman, Germanic, Slavic, and Indo-Aryan gods. Your teacher's example was in fact their prehistoric god of the sky andcan reduce key markers of inflammation. Chronic inflammation can lead to weight gain and various health problems ( , , ). Improved psychological well-being: One study found that eight weeks of intermittent fasting decreased depression and binge eating behaviors while improving body image in obese adults ( 4 ).

One study found that eight weeks of intermittent fasting decreased depression and binge eating behaviors while improving body image in obese adults ( ). Increased longevity: Intermittent fasting has been shown to extend lifespan in rats and mice by 33–83%. The effects on longevity in humans is yet to be determined ( 23 , 24 ).

Intermittent fasting has been shown to extend lifespan in rats and mice by 33–83%. The effects on longevity in humans is yet to be determined


( , ). Preserve muscle mass: Intermittent fasting appears to be more effective at retaining muscle mass compared to continuous calorie restriction. Higher muscle mass helps you burn more calories, even at rest ( 25 , 26 ). Specifically, the health benefits of intermittent fasting for women need to be studied more extensively in well-designed human studies before any conclusions can be drawn ( 27 ). Summary Intermittent fasting may help women lose weight and reduce their risk of heart disease and diabetes. However, further human studies are needed to confirm these findings.

Best Types of Intermittent Fasting for Women When it comes to dieting, there is no one-size-fits-all approach. This also applies to intermittent fasting. Generally speaking, women should take a more relaxed approach to fasting than men.find a method that works best for you and your lifestyle. Summary The easy way to get started is to choose one of the methods above and give it a go. Stop immediately if you experience any adverse effects.

Safety and Side Effects Modified versions of intermittent fasting appear to be safe for most women. That being said, a number of studies have reported some side effects including hunger, mood swings, lack of concentration, reduced energy, headaches and bad breath on fasting days ( 1 , 18 ). There are also some stories online of women who report that their menstrual cycle stopped while following an intermittent fasting diet. If you have a medical condition, you should consult with your doctor before trying intermittent fasting. Medical consultation is particularly


15th Virginia Infantry

The 15th Virginia Volunteer Infantry Regiment was an infantry regiment raised in Virginia for service in the Confederate States Army during the American Civil War. It fought mostly with the Army of Northern Virginia.

15th Virginia was organized in May 1861, with men from Richmond and Henrico and Hanover counties. The regiment was brigaded under McLaws, Semmes, and Corse, Army of Northern Virginia.

It fought with the army from the Seven Days' Battles to Fredericksburg, then was involved in Longstreet's Suffolk Expedition. During the Gettysburg Campaign, the 15th was on detached duty, and after serving in Tennessee and North Carolina participated in the battles at Drewry's Bluff and Cold Harbor. Later it took its place in the Petersburg trenches north and south of the James River and endedin a monarchy is generally inherited. The ruler, or monarch, is often only the head of state, not the head of government. An example of this kind of government is the United Kingdom.

Queen Elizabeth is one of the monarch of England as well as with Queen Victoria. These two queens have notice cultures just fancy Queen Victoria who really give a sterling importance to the morality of herself and her people while Queen Elizabeth have freedom of the British people to choose their own religion and to eradicate catholic persecution, the bring back the pride of the country. They are same y because the both of em possess noice culture. But they r different from the kind of life that they hae, because Queen Victoria hae a more


peaceful and chuffed childhood even though she's been trough to a lot of circumstances. Queen Elizabeth is full of troble from the day she was born because her doesn't fancy her and she's also been through to a lot of stepmothers. In terms wars they r also different because during Queen Victoria's time they encountered a war because they wanted Transvaal to be their extension or they conducted the war 4 the sake of their own. While during the time Queen Elizabeth war was encountered by the people of engerland because they just want to be free. from Spain, who treat em unkindly. Economy is bleedin' important to a certain gaff because these queen hae a sterling abilities to rule so they've rise the economic condition of engerlandMay 11, 2010

Senior Liberal Democrats have lashed out at the Labour Party over Nick Clegg's reluctant decision to hand David Cameron the keys to Number 10 Downing Street.

"I'm disgusted Labour didn't agree to adopt our entire manifesto as a basis for governing," said A Liberal Democrat Who Wasn't Nick Clegg Or Vince Cable, rumoured to be ear-marked by Cameron as the future Minister for Beards, one of four posts to be created especially so Liberal Democrats can be ministers without actually doing anything. "As a result, we have been forced into accepting the Tories' offer of a half-chewed peanut and a broken Dinky Toy."

In a joint statement, John Redwood and Nadine Dorries said they understood that there were concerns "dinosaurs" in the Parliamentary Labour Party might not accept


Christian groups seized on this proclamation to suggest God is moving with the times, saying the relative scale of the disease, with only a handful of people dying and others recovering, showed God was not as pissed off with homosexual people as He used to be. But atheist groups labelled this a logical fallacy, saying it could just mean God's powers are on the wane.

Other Christian groups said the disease had nothing to do with homosexuality. A trendy vicar from Muswell Hill said "We run the risk of making everything about our preoccupation with homosexuality, rather than listening to God and seeing what He has to say to us. Clearly this global pandemic is a punishment for the war on Iraq."

The Vatican issued a brief statement commending Godfor learning from his mistakes, by bringing forth a disease that could not be prevented through contraception.

Friday, April 24, 2009

The Provisional BBC will be awarding a prize of unspecified value for the best guess as to what the following person actually spends his money on. The excerpt is taken from the BBC's recent article where people earning over £100,000 pa complain about how they don't have enough money to live on and how they are not eligible for tax credits. Answers in the comments box, please.

Because my wife looks after the kids and hence does not currently work, she does not receive any tax free allowance and so we already are down to one allowance for the family. There is no married persons allowance any more to compensate


wearing clothes in a move bored journalists gleefully described as a "fashion challenge" to the US President. A spokesperson for Sarkozy denied the rumours, saying the wearing of clothes on state occasions was standard protocol.

"You can see that getting dressed is more than an official duty for Nicolas Sarkozy," said an annoying TV presenter. "Look at the way his shirt hugs every roll of flab - it just screams 'I want an international agreement on tax havens'."

But the leaders' decisions to wear clothes were criticised by campaigners, who said they should recognise ordinary people's hurt in this time of recession and go without.

In other news, the leaders also signed an historic agreement which could speed the end of the global recession by months.that he was "pissed," and that he would be coming

by the apartment to discuss the matter, warning her "not [to]

lie."

    Later that night, although Oliveira and his girl friend had

seemingly resolved the matter, he was still angry with the

defendant.    At approximately 12:15 A.M., Oliveira received a

telephone call and told his girl friend that he was going to

pick up Hodgate and would be right back.   He never returned.

    The last call made from Oliveira's cellphone was to

Hodgate's cellphone at 1:28 A.M.    At approximately 1:43 A.M., a

Swansea police officer on routine patrol saw a black Mercury

Sable (the make, model, and color of the defendant's automobile)

pull out of the driveway of the house with two people inside.


  7

object to the admission of certain cellphone record evidence,

failure to object to the admission of evidence of his bad

character, and failure to rebut the false testimony of a

cooperating witness.2   Finally, the defendant claims that the

admission of statements he made during an interview with police

violated his Miranda rights.   We examine each claim in turn.

     1.   Unauthorized police presence in the grand jury room.

During the Commonwealth's presentation to the grand jury in

support of indictments against the defendant, one or both of two

police officers involved in the investigation were present in

the grand jury room for most, if not all, of the witnesses'

testimony.   The defendant contends that the error, conceded by

the Commonwealth, requires not only the vacatur ofargument, and he did
not dwell on it.
                                                                   19

Pacheco testified that he had pleaded guilty to thirteen

criminal charges when, in fact, all but one had been dismissed

or placed on file, and the remaining one had been continued

without a finding.   The defendant blames both his counsel and

the prosecutor for this error, and argues that ineffective

assistance and prosecutorial misconduct in failing to correct

the


In The
Court of Appeals
Sixth Appellate District of Texas at Texarkana

______________________________

No. 06-04-00084-CR
______________________________

HARLAND VETTER, Appellant

V.

THE STATE OF TEXAS, Appellee

On Appeal from the 273rd Judicial District Court
Sabine County, Texas
Trial Court No. 5950

Before Morriss, C.J., Ross and Carter, JJ.
Memorandum Opinion by Justice Ross

MEMORANDUM OPINION

          Harland Vetter was convicted of attempted capital murder.  Vetter appealed.  The
trial court and the Texas Department of Criminal Justice - Institutional Division have
informed this Court that Vetter died December 19, 2004.
          The death of an appellant deprives an appellate court of jurisdiction.  Ryan v. State,
891 S.W.2d 275 (Tex. Crim. App. 1994); August v. State, 685 S.W.2d 56, 57 (Tex. Crim.
App. 1985).  When the appellant in a criminal case dies after the appeal is perfected but
before mandate issues, the appeal must be permanently abated. = newde;
            ht->table[iter->index] = newde;
            defragged++;
        }
    }
    return defragged;
}

/* Defrag helper for dict main allocations (dict struct, and hash tables).
 * receives a pointer to the dict* and implicitly updates it when the dict
 * struct itself was moved. Returns a stat of how many pointers were moved. */
long dictDefragTables(dict* d) {
    dictEntry **newtable;
    long defragged = 0;
    /* handle the first hash table */
    newtable = activeDefragAlloc(d->ht[0].table);
    if (newtable)


      (*defragged)++, de->key = newsds;
    sdsele = dictGetVal(de);
    if ((newsds = activeDefragSds(sdsele)))
        (*defragged)++, de->v.val = newsds;
    server.stat_active_defrag_scanned++;
}

long scanLaterHash(robj *ob, unsigned long *cursor) {
    long defragged = 0;
    if (ob->type != OBJ_HASH || ob->encoding != OBJ_ENCODING_HT)
        return 0;
    dict *d = ob->ptr;
    *cursor = dictScan(d, *cursor, scanLaterHashCallback, defragDictBucketCallback, &defragged);
    return defragged;
}

long defragQuicklist(redisDb *db, dictEntry *kde) {
    robj *ob = dictGetVal(kde);
    long defragged = 0;
    quicklist *ql = ob->ptr, *newql;
    serverAssert(ob->type == OBJ_LIST && ob->encoding  if ((newd = activeDefragAlloc(ob->ptr)))
        defragged++, ob->ptr = newd;
    /* defrag the dict tables */
    defragged += dictDefragTables(ob->ptr);
    return defragged;
}

long defragSet(redisDb *db, dictEntry *kde) {
    long defragged = 0;
    robj *ob = dictGetVal(kde);
    dict *d, *newd;
    serverAssert(ob->type == OBJ_SET && ob->encoding == OBJ_ENCODING_HT);
    d = ob->ptr;
    if (dictSize(d) > server.active_defrag_max_scan_fields)
        defragLater(db, kde);
    else
        defragged += activeDefragSdsDict(d, DEFRAG_SDS_DICT_NO_VAL);
    /* handle the dict struct */
    if ((newd = activeDefragAlloc(ob->ptr)))


* 4) call a callback per element, and allow the callback to return a new pointer for the element */
long defragRadixTree(rax **raxref, int defrag_data, raxDefragFunction *element_cb, void *element_cb_data) {
    long defragged = 0;
    raxIterator ri;
    rax* rax;
    if ((rax = activeDefragAlloc(*raxref)))
        defragged++, *raxref = rax;
    rax = *raxref;
    raxStart(&ri,rax);
    ri.node_cb = defragRaxNode;
    defragRaxNode(&rax->head);
    raxSeek(&ri,"^",NULL,0);
    while (raxNext(&ri)) {
        void *newdata = NULL;
        if (element_cb)
            newdata = element_cb(&ri,newsds = activeDefragSds(keysds);
    if (newsds)
        defragged++, de->key = newsds;
    if (dictSize(db->expires)) {
         /* Dirty code:
          * I can't search in db->expires for that key after i already released
          * the pointer it holds it won't be able to do the string compare */
        uint64_t hash = dictGetHash(db->dict, de->key);
        replaceSateliteDictKeyPtrAndOrDefragDictEntry(db->expires, keysds, newsds, hash, &defragged);
    }

    /* Try to defrag robj and / or string value. */
    ob


              defragged++, ob->ptr = newis;
        } else {
            serverPanic("Unknown set encoding");
        }
    } else if (ob->type == OBJ_ZSET) {
        if (ob->encoding == OBJ_ENCODING_ZIPLIST) {
            if ((newzl = activeDefragAlloc(ob->ptr)))
                defragged++, ob->ptr = newzl;
        } else if (ob->encoding == OBJ_ENCODING_SKIPLIST) {
        (e.g. client argv, output / aof buffers, etc.
     * but we assume most of these are short lived, we only need to defrag allocations
     * that remain static for a long time */
    defragged += activeDefragSdsDict(server.lua_scripts, DEFRAG_SDS_DICT_VAL_IS_STROB);
    defragged += activeDefragSdsListAndDict(server.repl_scriptcache_fifo, server.repl_scriptcache_dict, DEFRAG_SDS_DICT_NO_VAL);
    return defragged;
}

/* returns 0 more work may or may not be needed (see non-zero cursor),
 * and 1 if time is up and more work is needed. */
int defragLaterItem(dictEntry *de, unsigned long *cursor, long long endtime) {
    if (de) {
        robj *ob = dictGetVal(de);
        if (ob->type == OBJ_LIST) {


           if (current_key) {
                serverAssert(current_key == head->value);
                sdsfree(head->value);
                listDelNode(db->defrag_later, head);
                cursor = 0;
                current_key = NULL;
            }

            /* stop if wereached the last one. */
            head = listFirst(db->defrag_later);
            if (!head)
                return 0;

            /* start a new key */
            current_key = head->value;
            cursor = 0;
        }

        /* each time we enter this function we need to fetch the key from the dict again (if it


  * next key can be a list, and scanLaterList must be done in once cycle */
            if (!cursor)
                quit = 1;

            /* Once in 16 scan iterations, 512 pointer reallocations, or 64 fields
             * (if we have a lot of pointers in one hash bucket, or rehashing),
             * check if we reached the time limit. */
         were supporting Men Do Complain – is here. Please email me [email protected] if you’d like to join us in protesting against Male Genital Mutilation at the Thornhill Clinic. Thank you.

Share this: Share

Twitter

Facebook


really warms my heart. For all our many warts, I'm constantly amazed by the love our LGBT community is capable of showing, even to those who so hatefully opposed us.

Zach Phelps-Roper is reportedly the fourth of ten Phelps-Roper siblings to leave Westboro Baptist, which the Southern Poverty Law Center calls "the most obnoxious and rabid hate group in America." Many other members of the Phelps family have also broken away; additional high-profile escapees include Megan and Grace Phelps-Roper, Libby Phelps-Alvarez, and Nate Phelps.

Video footage of Zach Phelps Roper's interview with the Topeka Capital-Journal is after the jump.platinum agent and taxane per National Comprehensive Cancer Network (NCCN) guidelines unless there are contraindications for the initial surgical approach, in which case neoadjuvant treatment followed by possible interval debulking surgery and additional cycles of chemotherapy can be considered^[@CR10],[@CR11]^. The goal of surgery is for optimal (\<1 cm residual disease) or complete cytoreduction (no visible residual disease) in order to achieve the highest possible survival benefit^[@CR12]^. Unfortunately, not everyone will be optimally debulked and the majority of patients diagnosed at an advanced stage will most likely develop recurrence (80%) after initial treatment response with a median interval of 16 months^[@CR13],[@CR14]^.

The goal of 21^st^ century precision medicine is to identify clinically relevant groups of patients based upon shared clinicopathological and molecular characteristics in order to deliver the most efficacious treatment.


methylationEPIC arrays. The Illumina Infinium MethylationEPIC BeadChip Kit (Illumina, San Diego, CA, USA) allows quantification of more than 850,000 methylation sites across the human genome. Bisulfite-converted samples are denatured and neutralized before they are isothermally amplified overnight. The amplified product is fragmented enzymatically. After isopropanol precipitation, fragmented DNA is resuspended and placed onto Illumina methylationEPIC BeadChips and hybridized. There are two different bead types for each CpG locus, representing methylated or unmethylated DNA. The BeadChip is washed to remove unhybridized DNA, and the chip undergoes extension and staining. The arrays are scanned with the Illumina iScan, and methylation intensity is measured. Analysis is done using the Minfi R statistical package^[@CR25]^.

A total of 97 samples, which included 91 primary and 6 recurrent patients, yielded usable data. Of the 91tube controls were evaluated for gene expression. Initial analyses focused on inverse correlations between methylation status (hypermethylated or hypomethylated) and gene expression.

We next looked at the correlation between methylation status and gene expression. The 5,852 differentially methylated probes comparing HGSOC and fallopian tubes in our UIHC cohort represent 4,593 genes of which 725 are hypomethylated and 3,868 are hypermethylated. If hypomethylation directs up-regulation of gene expression and hypermethylation directs down-regulation of gene expression then an inverse relationship between methylation and gene expression should be meaningful. In our data 175 hypomethylated genes displayed higher expression and 1,173 hypermethylated genes displayed lower expression (Fig. [2C](#Fig2){ref-type="fig"}). This represents 24% and 30% of genes respectively. Thus, only about a quarter of differentially methylated loci show differences in expression consistent with a cis-acting factor.

To


three genes (c17orf64, IRX2, and TUBB6) with methylation patterns that discriminate among normal fallopian tubes, STIC, and HGSOC^[@CR38]^. Other investigators have reported on methylation biomarkers that identify HGSOC. Several studies identifying genes exhibiting promoter hypermethylation (E-cadherin or CDH1, H-cadherin, BRCA1, RASSF1A, APC, p14 ARF, p16INK4A, DAPK, RUNX3, TFPI2, SFRP5, and OPCM) have better sensitivity and specificity than CA-125, with some even detectable in serum or plasma^[@CR23],[@CR40]^. We did not specifically evaluate all of these genes but did investigate some of them and found similar promoter hypermethylation in CDH1, BRCA1, and RUNX3 while APC was hypomethylated in our HGSOC cohort compared to controls.

We also examined differential methylation patterns between primary and recurrent HGSOC tissues, as well as among patients who had optimal vs suboptimal surgical outcomes as defined above.in a specific tissue or circumstance, then that gene will remain unaffected and still be transcribed. Other factors such as long non-coding RNAs, micro-RNAs, and structural changes in the DNA can also affect gene regulation. The incongruent relationship between methylation and expression can also be due to other less common modifications of histones like the monoubiquitination of histone H2B (H2Bub1) that regulates gene expression whose loss leads to an open chromatin state and upregulation of immune modulators. An assay for transposase-accessible chromatin using sequencing (ATAC-seq) could be employed on further studies to validate such mechanisms as done by Hooda *et al*.^[@CR57]^.

In the future, a prediction model combining epigenetic signatures with other clinical and biologic variables may be able to better characterize patients into treatment groups. TCGA analyses designated


as RAD51C^[@CR15]^, as well as the effect of immune checkpoint inhibitors on hypermethylated MLH1^[@CR70]^, can be specifically assessed in the future.

Finally, in this study the stromal and epithelial composition of both the samples and controls were not quantified which may impact the results. In the future, an immunohistochemistry-based scoring system that addresses this limitation may be employed to reduce the impact of cellular distribution as a confounding variable. We used sections of fallopian tubes that included stromal components and not just the epithelial layer as controls. The TCGA used controls similar to ours, but we believe that a laser-dissected specimen that isolates the epithelium might have less potential biases^[@CR36]^. The logistics of obtaining enough paired RNA and gDNA from isolated epithelium from fimbriated ends of the fallopian tubeget; set; }
        public string UserInserted { get; set; }
        public string UserUpdated { get; set; }

        public virtual System System { get; set; }
        public virtual DataBase DataBase { get; set; }
    }
}

E passei essa lógica pra dentro do meu controller no [HttpPost]
        [HttpPost]
        public async Task<ActionResult<SystemDatabase>> PostSystemDatabase(SystemDatabase systemDatabase)
        {
            systemDatabase.CreatedAt = DateTime.Now;


saia do for que iria salvar, este era o erro. Logo pra corrigir isso eu passei o await _context.SaveChangesAsync(); pra dentro da condição do for ficando tudo da seguinte forma:
        [HttpPost]
        public async Task<ActionResult<SystemDatabase>> PostSystemDatabase(SystemDatabase systemDatabase)
        {
            systemDatabase.CreatedAt = DateTime.Now;
            systemDatabase.UserInserted = (HttpContext.User.Identity as ClaimsIdentity).Name;

            for (int i = 0; i < systemDatabase.IdDatabases.Count(); i++)
            {
            if (png_ptr->push_length == 0)
            return;

      if ((png_ptr->mode & PNG_AFTER_IDAT) != 0)
         png_benign_error(png_ptr, "Too many IDATs found");
   }

   if (chunk_name == png_IHDR)
   {
      if (png_ptr->push_length != 13)
         png_error(png_ptr, "Invalid IHDR length");

      PNG_PUSH_SAVE_BUFFER_IF_FULL
      png_handle_IHDR(png_ptr, info_ptr, png_ptr->push_length);
   }

   else if (chunk_name == png_IEND)
   {
      PNG_PUSH_SAVE_BUFFER_IF_FULL
      png_handle_IEND(png_ptr, info_ptr, png_ptr->push_length);

      png_ptr->process_mode = PNG_READ_DONE_MODE;


can still
       * be handled, otherwise (Z_NO_FLUSH) a future zlib
       * implementation might defer output and therefore
       * change the current behavior (see comments in inflate.c
       * for why this doesn't happen at present with zlib 1.2.5).
       */
      ret = PNG_INFLATE(png_ptr, Z_SYNC_FLUSH);

      /* Check for any failure before proceeding. */
      if (ret != Z_OK && ret != Z_STREAM_END)
      {
         /* Terminate the decompression. */
            */
            return;
         }

         /* Do we have a complete row? */
         if (png_ptr->zstream.avail_out == 0)
            png_push_process_row(png_ptr);
      }

      /* And check for the end of the stream. */
      if (ret == Z_STREAM_END)
         png_ptr->flags |= PNG_FLAG_ZSTREAM_ENDED;
   }

   /* All the data should have been processed, if anything
    *


  break;
         }

         case 2:
         {
            int i;

            for (i = 0; i < 4 && png_ptr->pass == 2; i++)
            {
               png_push_have_row(png_ptr, png_ptr->row_buf + 1);
               png_read_push_finish_row(png_ptr);
            }

    not significantly different than that of women from monozygotic pairs or same-sex dizygotic pairs. Of the five male anorexia nervosa probands, only one was from an opposite-sex twin pair. Bulimia nervosa in men was too rare to be assessed by zygosity; the prevalence of DSM-IV or broad bulimia nervosa did not differ in women from opposite- versus same-sex twin pairs. In both sexes, the overall profile of indicators on eating disorders was rather similar between individuals from opposite- and same-sex pairs. The authors found little evidence that the risk for anorexia nervosa, bulimia nervosa, or disordered eating was associated with zygosity or sex composition of twin pairs, thus making it unlikely that in utero femininization or masculinization or socialization effects of growing up with an opposite-sex twin have


"Go Mi Nam." "What kind of accident did you cause now?" "Hwang Tae Kyung." "Are you going to take care of Go Mi Nam again?" "Then again..." "That kid's such a half-wit, it must be tiring for you to keep taking care of her." "Yeah." "I am tired." "She's not as good at lying as you are." "But she was pretty good at lying himself." "She said that my pin was the one she lost and kept demanding that I give it to her." "She must have been jealous of it since she is a girl." "What?" "That..." "Yeah, this." "That's what she lost?" "This is mine." "She lost hers and then kept demanding for mine." "It's probably because it looks the same." "Did you see it?" "Ifind it even if he wanted to." "Even though I don't know what it is, that's really unfortunate." "If she wanted to find it, she should have just said she wanted to find it." "Why did she say she didn't want to find it in the middle and put me in an uncomfortable spot?" "If I give it to her after telling her not to look for it, I'll look like an idiot." "Forget it." "I just won't give it to her." "No..." "If I think about it calmly, there must be a way for me to give it to her without looking stupid." "Ah, that pig rabbit punk is such a pain, she's killing me." "Yes." "Pig rabbit!" "I have to find one rabbit and one pig."


"Don't come close." "The pollen's flying everywhere." "How can you be tired at the beginning of filming?" "There's so much more." "It must be hard to eat all that." "If I eat all that, my tongue will fall off." "If I eat all that, I'll turn into a monkey." "I will do my hardest." "Why?" "So you can look good to the advertisement company?" "Suck-up." "Be fair." "Now, now." "My A.N.JELL, are you filming well?" "I brought someone to cheer you up." "Ta-Da!" "Your color is lime!" "That's my favorite color." "They matched it really well." "As the color that's most popular with women of ages 20-30, Tae Kyung is lime." "Cute Jeremy who is most popular with children is yellow." "Because of your calmness and most likedU.S.C.

523(a)(6)  (1989).1   Subsequently,  he  filed  a motion  for

summary judgment on his claim.  The bankruptcy court not only

denied his motion, it sua sponte granted  summary judgment to

the landlords.  The district court affirmed.  Because we find

that summary judgment should have been entered for Piccicuto,


day or  so

late,  Jeffrey  Dwyer deluged  him  with  notices of  breach,

notices  of  termination,  and  notices  to quit.    He  also

commenced a barrage  of noise complaints to the  police, none

of  which was substantiated to  the point of  police or court

action.    In  addition,   in  January  1985,  the  landlords

initiated what became series of eviction  proceedings against

Piccicuto.   All  of  these proceedings  eventually concluded

with judgments in Piccicuto's favor.

                             -4-
 the  landlords   under  a  theory  of  vicarious

liability.

          The bankruptcy court rejected these arguments.  For

reasons that  are not  entirely clear, it  misapprehended the

                             -6-
                                          6

thrust of Piccicuto's first  argument and looked only  to the

special  verdict


     For the reasons stated above,  the bankruptcy court

erred  in awarding summary  judgment to the  landlords and in

not awarding summary judgment to  Piccicuto.  It follows that

the district court erred  in affirming the bankruptcy court's

mistaken order.  We therefore  reverse the judgment below and

enter summary judgment for Piccicuto.

          So ordered.
                      So ordered.
                             our numerical results concerning dynamical single and binary black hole configurations.

Theoretical background {#sec:background}
======================

In this section, we briefly discuss the parabolic-hyperbolic formulation of the constraints pioneered in [@Racz2015] and set up the corresponding initial-boundary value problem [@Racz2018; @Racz2018-SM].

The constraints as a parabolic-hyperbolic system {#sec:parab-hyperb}
------------------------------------------------

Vacuum initial data on a given three-dimensional Riemannian manifold $\Sigma$ are constructed by solving the vacuum constraints for the pair of symmetric tensors $(h_{ij}, K_{ij})$, where $h_{ij}$ is a Riemannian three-metric. In vacuum the Hamiltonian and momentum constraints read [@Choquet-Bruhat2009]: $$\begin{aligned}
 \label{hamiltonian}
 {}^{(3)} &R + K^2 -K_{ij} K^{ij} = 0, \\
 \label{momentum}
 & D_j K^j{}_i  - D_i K = 0,\end{aligned}$$ where $K = h^{ij}K_{ij}$, ${}^{(3)}R$ and $D_i$ denote the scalar curvature and the covariant derivative operator associated with the three-metric $h_{ij}$, respectively.

In order to formulate


\mathcal{A}\, \widehat N + \mathcal{B}\, \widehat N{}^3,\\
\label{momentum_kx_cart}
&\partial_z {\bf k}_x = B_1\, \partial_x {\bf k}_x + B_2\, \partial_y {\bf k}_x +
B_3\, \partial_x {\bf K} + B_4,\\
\label{momentum_ky_cart}
&\partial_z {\bf k}_y = C_1\, \partial_x {\bf k}_y + C_2\, \partial_y {\bf k}_y +
C_3\, \partial_y {\bf K} + C_4,\\
\label{momentum_K_cart}
&\partial_z {\bf K} = D_1\, \partial_x {\bf K} + D_2\, \partial_y {\bf K} +
D_3\, \partial_x {\bf k}_x + D_4\, \partial_x {\bf k}_y + D_5\, \partial_y {\bf k}_x
+ D_6\, \partial_y {\bf k}_y + D_7, \end{aligned}$$ where ${\bf k}_x, {\bf k}_y$ are the components of the vector ${\bf k}_A$ along the $x,y$ direction,[^1] respectively; the functions $\mathcal{A}$ and $\mathcal{B}$ have been defined above; and the exact expressions of the functions $A_i, B_i, C_i, D_i$ are given in Appendix \[sec:appendixA\]. In Sec. \[sec:numer\_implement\] the abovehere. It turns out that although the metric does not satisfy Einstein’s vacuum equations, it is a very good candidate for our purposes here as it is asymptotically flat and can be used to approximate the regions close to the individual black holes quite well . At first sight, such a proposal seems at least preposterous. A closer look though puts things back in place again as the numerically computed solutions of the constraints - will always differ from the corresponding fields that could be deduced analytically from the metric .

Numerical implementation {#sec:numer_implement}
========================

Setting up the numerical scheme {#sec:numer_scheme}
-------------------------------

We choose to solve the constraints - numerically using the so-called Alternating Direction Implicit (ADI) method. An implicit method was preferred over the explicit methods mainly because of its superior stability


discretised in a similar fashion, i.e. $(\mathbb{F}_A)_{ij} = \mathbb{F}_A(x_i, y_j)$.

Next, the spatial derivatives of the constraint fields are approximated with appropriate finite difference operators. As the ADI method is second order accurate in the spatial coordinates, we accordingly choose to use second order central difference operators to approximate the first and second derivatives appearing in -.

The resulting semi-discrete system of ordinary differential equations will be evolved along the $z$-direction with the operator splitting ADI method introduced above. Remember that in the setting of Fig. \[Fig:IBVP\], $z$ is the “dynamical" coordinate along which evolution takes place.

Now, in order to check the convergence of our numerical solutions, we define the convergence rate as follows $$\label{conv_rate}
  \mathrm{CR} = \frac{\log_2(E_0/E_1)}{\log_2(h_0/h_1)},$$ where $E_0$ and $E_1$ are the normalised $l^2$–norms of the errors ofof mass $M = 0.5$ is placed on the $y$-axis at distance $d = 2.5$ from the origin, moves along the $x$-axis with velocity $\upsilon
= 0.6$, and carries spin $a = 0.15$ along the $z$-axis. The computational domain is the same as in the stationary case, i.e. $-4 \leq x \leq 4$, $-1.5 \leq y \leq 6.5$, and $0 \leq z \leq 4$.

Fig. \[Fig:Kerr\_dist\] depicts the constrained fields $(\widehat N,\,
{\bf k}_A,\, {\bf K})$ resulting from the numerical solution of the system - for the aforedescribed configuration at $z=0.5$. Notice that based on these numerical values of $(\widehat N,\, {\bf k}_A,\, {\bf K})$, the physical quantities $(h_{ij},
K_{ij})$ can be reconstructed directly from the expressions .

The left and right panels of Fig. \[Fig:Kerr\_comparison\] depict the components of the constrained


even comes with mounting screws and security stickers.

Connect to a Digital Video Recorder
Old video surveillance systems used to require a remote access system, a camera multiplexer; a time-lapse VCR, and an unlimited supply of videotapes for remote viewing and digitally storing video from a multi-camera system. Now you can get the capabilities of all those products in one with a Digital Video Recorder (DVR). By connecting multiple cameras to a DVR, you will be able to record and review video footage of activity around your property. You can even remotely access your video footage using a Network Digital Video Recorder (NDVR).

IR LEDs
Infrared (IR) cameras can pick up images in total darkness. Most IR cameras send out IR light from light emitting diodes (LEDs), which can not be seenwith the LEDs on.

Resolution
Resolution is the amount of horizontal TV lines that make up a picture, so the higher the number of the resolution, the better clarity your picture will have. Note that the monitor or recording device you use must have a resolution equal to or greater than the resolution of the camera, as it will do you no good to have a camera that can output in 540 lines of resolution but have a monitor or recording devices that only picks up images at 300 lines of resolution. The LED Array Outdoor Camera has 420 lines of resolution, slightly less than broadcast television.

Ingress Protection Rating
Ingress Protection (IP) is a rating system for electronic products as it relates to the amount of sealing they have against the


  for (var i = 0; i < categories.length; i++) {
            if (categories[i].id === categoryId) {
                categories.splice(i, 1);
            }
        }

        this.currentCategoriesSubject.next(categories);

        if (!categories.length) return;

        this.currentCategorySubject.next(categories[0].id);
    }
}

The part I need to mock is the public property category.
I am not sure how to go about mocking that. Does anyone have any idea?
This is the ngOnInit method for the component I amthis.products = range;
                this.range = this.productModelService.mapProducts(rangeFields, range);
                this.saveForm = this.toFormGroup(range[0]);
            });
        });
    });
}

private toFormGroup(product: any): FormGroup {
    let group: any = {};

    this.fields.forEach(field => {
        group[field.name] = new FormControl(product[field.name]);
    });

    return new FormGroup(group);
}

A:

I was able to fix this by using the first option:
import { Spectator, createComponentFactory, mockProvider } from '@ngneat/spectator';
import { HttpClientTestingModule } from '@angular/common/http/testing';
import { ReactiveFormsModule }