McArdle called 911, Anthony Bucci, a patrol officer in the Cranston Police

Department, received a dispatch concerning the shooting that described the two cars: a red

Acura and a white Acura, driven by Asian males. Traveling in an unmarked police car, Officer

Bucci went to 83 Chestnut Street in response to the dispatcher’s direction that the suspects may

have been heading there. Once on Chestnut Street, Officer Bucci saw a red Acura, occupied by

two Asian males. He testified that, when he made eye contact with the driver, the driver’s eyes

“became wide” and “the vehicle sped off and began traveling at a high rate of speed.” Officer

Bucci pursued the car, and after he stopped it, the passenger exited the car and the driver moved

to the passenger seat. He testified that he recognized theinvade the jury's fact-finding role by proffering an opinion, unless that

opinion is based upon personal perception and helps the jury.” Mann, 889 A.2d at 168 (citing

State v. Barrett, 768 A.2d 929, 940 (R.I. 2001)).

       At trial, Saraceno testified that Tep “aimed” the gun at him and the other men on the

porch and that Tep was “focused on—at, in my mind, hitting one of us.” Tep argues that this

statement indicated what Saraceno believed to be Tep’s mental state at the time of the shooting.

We disagree. Saraceno’s statement merely described what he perceived, not what he believed

Tep thought or intended. Observing Tep’s demeanor and the pointed gun, Saraceno rationally


image was magnified by a factor of two and the 13 frames with the largest Strehl ratios were combined.

Data Analysis and Results
=========================

The Images
----------

Figures 1$-$3 show the final diffraction-limited images of HD 98800. The resolution ranges from 0.$''$03 at 1.25$\mu$m to 0.$''$46 at 18.2$\mu$m. The components of the 0.$''$8 north-south pair are easily distinguished out to 12.5$\mu$m. At 18$\mu$m, the southern component, A, is marginally detected at $\sim$3$\sigma$. As originally suggested by @geh99 and confirmed by @koe00 on the basis of their mid-IR data, the dust is associated with the northern component, HD 98800 B. Between 1$-$18$\mu$m there is no evidence of dust around HD 98800 A. Our mid-IR fluxes agree with those of @koe00 to within 1$\sigma$ at almost every wavelength common to both data sets.

We inspected eachthe Poynting-Robertson lifetime of the grains, and apparently significantly vertically extended. Orbital periods in the models proposed by @tok99 range from 300 to 430 years, allowing for relatively short term periodic perturbations of the HD 98800 B disk, initiated during periastron passage with HD 98800 A.

Summary
=======

We have resolved the 0.$''$8 visual binary components in the young stellar system HD 98800 from 1$-$18$\mu$m, obtaining complete resolved observations of the silicate emission feature at 10$\mu$m through six narrow-band filters, and of the 18.2$\mu$m flux. The mid-IR excess appears to be azimuthally symmetric and is entirely associated with HD 98800 B, a double-lined spectroscopic binary. The PSF of HD 98800 B is similar to that of HD 98800 A in at least the 4 filters spanning 8.8$-$11.7$\mu$m, and implies an upper


and the National Aeronautics and Space Administration (NASA). The Observatory was made possible by the contributions of the W. M. Keck Foundation. This research was supported by the NASA Origins of Solar Systems Program grant NAG5-6975 and the Packard Foundation; additional funding for the AO portion of this work was provided by the NSF Science and Technology Center for Adaptive Optics.

Artymowicz, P., and Lubow, S. 1994, , 421, 651 Backman, D. E., and Paresce, F. 1993, in [*Protostars and Planets III*]{}, ed. E. H. Levy and J. I. Lunine (Tucson: Univ. of AZ Press), 1253 Baraffe, I., Chabrier, G., Allard, F., and Hauschildt, P. H. 1998, , 337, 403 D’Antona, F., and Mazzitelli, I. 1994, , 90, 467 D’Antona, F., and Mazzitelli, I. 1997, ’Evolution of Low Massup for Stiller to become one of the biggest comedy stars of the ’00s. It also brought a new relevance to the aged actor who had moved on from working with Martin Scorsese but hadn’t really made much of a mark on his own. Meet the Parents was an even bigger hit than De Niro’s pairing with Billy Crystal in Analyze This.

Six years ago, the two reteamed for the sequel Meet the Fockers, which opened on the exact same Christmas weekend and exploded with $70.5 million in its first five days leading to nearly $280 million total. To date, it’s still Ben Stiller’s highest-grossing movie and that includes the family-minded Night at the Museum and Madagascar movies and their respective sequels. De Niro hasn’t really been doing much


they’re a pairing that’s brought so much to so many movies including Todd Phillips’ Starsky & Hutch. Similarly, Dustin Hoffman and Barbara Streisand are back from the last movie, and they’ll do a lot to bring in older moviegoers, along with De Niro. Apparently, someone wondered what might happen when you pair the star of Good Luck Harvey with Good Luck Chuck, which is the only real explanation why Jessica Alba is in the movie as a ditzy drug rep – yes, one whom is even ditzier than Jake Gyllenhaal in Love and Other Drugs. Alba doesn’t do a lot of comedy, probably for good reason, but she is still very hot.

Taking over the directorial chair from Jay Roach is Paul Weitz, who made great in-roads into Hollywoodgenerations which is why he was able to host “Saturday Night Live” this past weekend as well as bring in a younger audience with his return to one of his most popular characters with last week’s TRON: Legacy.

Possibly an even bigger draw is the presence of actor Matt Damon who is prominently advertised on the posters and who brings a bit more starpower than Bridges, even though other than the “Jason Bourne” and “Danny Ocean” movies, Damon’s movies generally have opened in the $10 to 15 million range rather than those blockbusters getting audiences in for his other movies. For example, Damon’s last four movies ended up grossing less than $40 million where many of his bigger movies might do that amount their opening weekend. The Coens also


box office.Projections: $12 to 13 million on Wednesday and Thursday and another $16 to 18 million over the weekend on its way to roughly $65 million total, more if it gets Oscar nominations.

Weirder things have happened over the holidays then having a movie that reinvents Jonathan Swift’s popular literary classic as a comedy vehicle for Jack Black or as he’s being credited for the movie, “Jack Black, the Voice of Kung Fu Panda.” Yes, it’s come to the fact that Black is such a cartoon character that the studio feels the need to remind people that his biggest movie was when he voiced another cartoon character that is popular with kids. Black’s popularity has remained fairly steady with moderate hits like the family-friendly School of Rock, but itan actress to be able to switch gears so effortlessly, but it does seem unnatural and it makes her less likeable as well. Its much easier to like Tom and Gerri, though they do end up throwing Mary under the bus when she needs them most, Gerri wiping her hands of Mary due to her negative comments about Joes girlfriend.

This last segment is almost a short film in itself, as the family travels North for the funeral of Toms brothers wife. Dave Bradley brings a lot to the role of Toms brother Ronnie, and his son Carl bringing some much needed excitement to the mix; when Ronnie and Mary come together, its one of the more touching moments before were pulled even deeper into Marys depression as the


about it often.

But he was, as I say, a football man. He supported Manchester United before it was unpopular to do so, though to my knowledge he had never been there and in all probability had only the sketchiest of ideas as to where Manchester was, none of the major public schools being located in that city. (He also, as I recall, had only the sketchiest idea as to who Dave Bennett was when that player scored in the 1987 Cup Final. Con, watching on television, attributed the goal to Cyrille Regis, a player who resembled Dave Bennett only in wearing a Coventry shirt and being black.) He had a much more highly developed opinion (though one as woefully ill-informed) of his own abilities as a footballer, believinghad twenty years—Twenty years largely wasted, the years of l'entre deux guerresTrying to use words, and every attemptIs a wholly new start, and a different kind of failureBecause one has only learnt to get the better of wordsFor the thing one no longer has to say, or the way in whichOne is no longer disposed to say it.

But what words should I try to use? I should, by Constantine's standards, be jealous of him. I doubt that he could interpret my feelings in any other way. Success is the measure of man, and money is the measure of success.

But I am not jealous. Of what accomplishments could I be jealous? He has done nothing - nothing that I value, nothing for anybody save himself. Nor has he done


happen: there is no sense of wishing it were otherwise.

Moreover opera is an art form with a repertoire: the material is not new, the conclusion and the working-out are already familiar. The pleasure in Puccini is not the plot, any more than it is in Shakespeare, where there is no capacity to surprise us. We need to know what is going on (I was not, in fact, totally familiar with La Boheme, nor with the Spanish in which the surtitles naturally were written) in order to appreciate the meaning of the songs. But the chances are we know how this is going to turn out, and even if we do not, the ending will not surprise us any more than we can be surprised by the death ofhad leaned over the basin to spit, to also splutter, gag and retch, to spit into the basin not only the contents of my throat but, to judge from the tearing feeling and the spots of blood, much of the throat itself.

Mercifully, the throat remained intact. The blood was actually from closer to the mouth, as I discovered shortly, when I began to brush my teeth and found myself obliged instead to swill several glasses of water before the bleeding subsided. I have recently had a tooth extracted - the third of its family to disappear - and the resulting cavity is still both deep and sensitive. One fears to touch it with a brush because of the likely short-term consequences - some pain, some bleeding, some soreness,


another. He beat it out so quickly, it was barely singed.

Having seen it happen probably saved my hair at least, and maybe more besides, as I simply battered my head with my hands until I was sure the fire was out. Little damage was done, and hairs with split ends might as well be singed a little anyway for all the difference that it makes. But after that, I decided that it was a sign from God to get my hair cut, and I did: a halfway house between the length that it was previously, down to the small of my back, and the French crop that I got fifteen years later, and which I will still have, later on today.

French crop. I didn't know, when I wentto the hairdresser's, what it was actually called: in my naivete I assumed that if you named somebody famous, the hairdresser, who presumably did nothing else than read OK! magazine and talk about the hairstyles of the rich and famous, would instantly recognise both name and cut. Graeme Le Saux was famous then - he played his last game for England in the very year I chose him as the model for my makeover. But not, as it happened, famous enough. Or not in Thame, at any rate. The hairdresser had no idea who I was talking about and there was not a copy of OK! around to help us out. Except that the bloke in the adjacent chair not only knew the player, but his cut -


22 games and pitched nine complete games, is the fourth winner from the Blue Jays in the last eight seasons. More >

2003 winner: Eric Gagne, LA

Game over: Gagne wins Cy Young
Dodger closer Eric Gagne was named winner of the 2003 National League Cy Young Award by the BBWAA, snapping Randy Johnson's four-year stranglehold on the award. Gagne became the first Dodger to win the Cy since Orel Hershiser in 1988 and the first reliever since Oakland's Dennis Eckersley in 1992. More >

2003 winner: Angel Berroa, KC

Angel in the infield: Berroa tops in AL
In the closest voting since the 5-3-1 voting system was adopted in 1980, Kansas City's Angel Berroa beat out New York's Hideki Matsui by four points for American League Rookie of the Year. Among rookies whoHOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.


figures are illustrated for simplicity and clarity and have not necessarily been drawn to scale. For example, the dimensions and/or relative positioning of some of the elements in the figures may be exaggerated relative to other elements to help to improve understanding of various embodiments of the present invention. Also, common but well-understood elements that are useful or necessary in a commercially feasible embodiment are often not depicted in order to facilitate a less obstructed view of these various embodiments of the present invention. Certain actions and/or steps may be described or depicted in a particular order of occurrence while those skilled in the art will understand that such specificity with respect to sequence is not actually required. The terms and expressions used herein have the ordinary technicalThursday, November 30, 2006

Matthew 11:28-30 28"Come to me, all you who are weary and burdened, and I will give you rest. 29Take my yoke upon you and learn from me, for I am gentle and humble in heart, and you will find rest for your souls. 30For my yoke is easy and my burden is light."

It is becoming very apparent to me in my old age that savoring the holidays is something that is really important. I have lived long enough to figure out that packing your holidays to the brim is not a way to enjoy them. So this holiday season (one that I am not that enthused about) I am warning you now, I will not pack my calendar to the rim. Please don’t be offended


by this, if I say no, it doesn’t mean that I don’t love you, I didn’t take offense when you didn’t meet me for lunch or come out on the boat, please don’t think I love you any less if I say no. Oh, and by the way, if it means extra money will be spent, it’s pretty much out. The cost of butter and sugar (at a 20 year price high) is an extra expense, not to mention presents.

I refuse to be a mean shopper or someone who forgets what this holiday is all about, because it’s about Jesus, and no offense, He’s all I need. He’s my mashed potatoes (and beans) everything else is all jello salad and gravy.

I know this sounds pretty scroogie but ifme up.2. They are both filling.3. Beans and blessings are inexpensive and widely available. Blessings are a gift from God, they don’t cost us a thing and they are available everywhere.4. Both come in wide varieties, Garbanzo, Northern, Green, and home, food, friends, etc.5. Beans and blessings can help cure obesity. (this is all about me). Beans are low in calories and fat, and when I think of all my blessings I am more likely to eat things that are good for me or not eat because I am depressed.

Psalm 128:2 You will eat the beans; blessings and prosperity will be yours.Ok… so the real verse is Psalm 128:2 You will eat the fruit of your labor; blessings and prosperity will be yours.

Tuesday, November 28, 2006

I sit here


and how tough it is when you have someone in our families who runs from God, and us.

He asked if anyone in our families was a Prodigal Son. I have quite a few. So much so that people in my family have accepted it. I stand here today, telling you that I will not accept it. It is not something like "she likes oranges, but no one else does". Nope being far from God is something that I plan to take a stand against. Thankfully our Pastor, being wise like he is, gave us some steps on what to do. One of them is prayer, ok, great, I already pray for them, maybe I just don't know what to pray. Then he gave us the scariest of prayers,know I am a huge nerd-o. Please bear with me while I am overwhelmed with gratitude to the Most High.

I decided, "oh I got a few minutes, I'll throw some stuff together for a donation to St Vincent DePaul's". 10 minutes later, 6 bags, 3 backpacks, a winter coat, 2 pairs of ice skates, and a partridge in a pear tree I realized how blessed I was. These were things I was going to sell at my garage sale last year.

I know people who shop for their kids at Thrift stores because they don't have enough money to buy new things. What we consider poor and what they consider poor are completely 2 different things. I am going to ask you something today... do you have something in


Mortenview, there was a new Subdivision going up, and then down the road, Condos for sale…

Don’t we have enough housing? For crying out loud, there are a ton of homes for sale and people are LEAVING Michigan. Homes in foreclosure, people desperate to move out of their houses, and we’re building more.

How about we use what we have?

I am guilty of going to the grocery store and buying more, even when I have plenty in the fridge, cupboard, and freezer to make dinner. I am trying to get better and make what I have. Maybe it’s a small lesson that needs to be learned on a bigger scale.

I love my 1250 sq foot house. It’s a little packed at holidays or gatherings, but it forces people to actuallyt \geq 0\}$, where the random variable $S(t)$ represents the number of susceptible individuals at time *t*, and the aim is to compute transient probabilities $p_{S}{(t)} = \mathbb{P}{(S{(t)} = S)}$ for any $S \in \Omega = \{ 0,1,\cdots,N\}$, where *N* is the number of individuals in the population. These probabilities satisfy the Kolmogorov differential equations: $$\begin{array}{rcl}
\frac{dp_{S}{(t)}}{dt} & = & {- \lambda Sp_{S}{(t)} + \lambda{(S + 1)}p_{S + 1}{(t)},\quad S \in \Omega.} \\
\end{array}$$

Interevent times are assumed to be exponentially distributed and the stochastic process is simulated using the Gillespie algorithm (Gillespie, [1976](#risa13300-bib-0007){ref-type="ref"}). In particular, this algorithm generates samples of the interevent times by using the fact that $$\begin{array}{rcl}
{U \sim U(0,1)} & \Rightarrow & {T = - \frac{\ln(U)}{\lambda S} \sim \exp{(\lambda S)},} \\
\end{array}$$

and then updates the state of the system


individuals, $i_{j}$, in every zone $1 \leq j \leq M$, due to airflow. In Noakes and Sleigh ([2009](#risa13300-bib-0020){ref-type="ref"}), the spatial distribution of infectious material is represented through the differential equation: $$\begin{array}{ccl}
{V_{k}\frac{dC_{k}}{dt}} & = & {q_{k}i_{k} - Q_{o,k}C_{k} - \sum\limits_{j}\beta_{kj}C_{k} + \sum\limits_{j}\beta_{jk}C_{j},} \\
 & & {1 \leq k \leq M,} \\
\end{array}$$where $V_{k}$ is the volume of zone *k*, $q_{k}i_{k}$ is the generation rate of infectious quanta, $Q_{o,k}$ represents the extract ventilation rate in zone *k*, and $\sum_{j}\beta_{kj}C_{k}$ and $\sum_{j}\beta_{jk}C_{j}$ amount to the volume flow of air between zones *k* and *j*. Moreover, each interzonal flow rate $\beta_{kj}$ represents the sum of two contributions: $$\beta_{kj} = \beta_{0} + \beta_{Qkj},$$where β~0~ is a global mixing rate and $\beta_{Qkj}$ is an additional contribution representing net flow across the $k/j$ zonal boundary, from\right.$   $\lambda_{j}{(i_{1},\cdots,i_{M})}{(N_{j} - i_{j})}$
  Discharge of an infective patient in zone *j*    $\left. {(i_{1},\cdots,i_{j},\cdots,i_{M})}\rightarrow{(i_{1},\cdots,i_{j} - 1,\cdots,i_{M})} \right.$                    $\gamma_{j}i_{j}$
  Detection of the outbreak                                                $\left. (i_{1},\cdots,i_{M})\rightarrow\Delta \right.$


               $\left. (i_{1},\cdots,i_{M},D - 1)\rightarrow\Delta \right.$                                $\sum\limits_{j = 1}^{M}\delta_{j}i_{j}$

John Wiley & Sons, Ltd.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

Our arguments in the subsections above can be adapted for process $\mathcal{X}^{aug}$. For example, Equations [(4)](#risa13300-disp-0011){ref-type="disp-formula"} and [(5)](#risa13300-disp-0012){ref-type="disp-formula"} become $$\begin{array}{ccl}
 & & {an air change rate of 3 AC/h. Diagrams of the ventilation flows and specific rates within and between each zone for each setting are given in Fig. [2](#risa13300-fig-0002){ref-type="fig"}. Moreover, we set $p_{i} = 0.01\mspace{6mu} m^{3}/\min$ and $q_{i} = 0.5\mspace{6mu}{{quanta}/\min}$ for all patients at all zones and for every ventilation scenario (Noakes & Sleigh, [2009](#risa13300-bib-0020){ref-type="ref"}), and assume an average LOS for each patient $\gamma_{i}^{- 1} = 7$ days.

![Diagrams of the ventilation settings considered, and corresponding ventilation matrices **V** (for $\beta_{0} = 9\mspace{6mu} m^{3}/\min$). Gray arrows: ventilation between zones ($\beta_{ij}\!$, m^3^/min); black arrows: ventilation supply and extract to the ward; circled values: extract ventilation rates ($Q_{o,j}$, m^3^/min)](RISA-39-1825-g002){#risa13300-fig-0002}

If we order the $M = 9$ ventilation zones as $$1a \prec 1b \prec c1 \prec 2a \prec 2b \prec c2 \prec 3a \prec 3b \prec


detection of the outbreak can be split according to where these infections actually occur as $$\begin{array}{rcl}
R & = & {R(1) + R(2) + R(3),} \\
\end{array}$$where $R(j)$ is the number of infections occurring at bay *j*. Although probabilities $\mathbb{P}(R(j) = n)$ can be analytically computed by adapting arguments in Section [3](#risa13300-sec-0050){ref-type="sec"}, details are omitted here for the sake of brevity, and results in Table [VII](#risa13300-tbl-0007){ref-type="table"} are obtained from 10^6^ stochastic simulations of the process.

######

Mean Values of *E*\[*R*\], $E\lbrack R(1)\rbrack$, $E\lbrack R(2)\rbrack$, and $E\lbrack R(3)\rbrack$ for $\beta_{0} = 9\mspace{6mu} m^{3}/\min$, $\delta^{- 1} = 48$ h and Ventilation Settings A, D, and E; Initially Infective Individual in Zone 1*a*

  Regime    *E*\[*R*\]   $E\lbrack R(1)\rbrack$   $E\lbrack R(2)\rbrack$   $E\lbrack R(3)\rbrack$
  -------- ------------ ------------------------ ------------------------event representing that, if the process is initially at state $(i_{1},i_{2},\cdots,i_{j},\cdots,i_{M})$, it moves to state $(i_{1},i_{2},\cdots,i_{j} + 1,\cdots,i_{M})$ in the next *jump* (i.e., that we have $(i_{1},i_{2},\cdots,i_{j},\cdots,i_{M})$ infectives within the hospital ward at current time, and the next event that occurs is an infection in zone *j*). From the theory of CTMCs, it is well known that the probability of this event occurring is: $$\begin{array}{ccl}
 & & \left. \mathbb{P}({(i_{1},i_{2},\cdots,i_{j},\cdots,i_{M})}\rightarrow{(i_{1},i_{2},\cdots,i_{j} + 1,\cdots,i_{M})}) \right. \\
 & & {\quad\quad\quad = \frac{\lambda_{j}{(i_{1},\cdots,i_{M})}{(N_{j} - i_{j})}}{\sum_{k}{(\lambda_{k}{(i_{1},\cdots,i_{M})}{(N_{k} - i_{k})} + {(\gamma_{k} + \delta_{k})}i_{k})}};} \\
\end{array}$$that is, it is equal to the ratio between the rate corresponding to this event and the sum of all the rates corresponding to all the possible events that can actually occur (infection in any zone, discharge in any zone, or detection


Real-time evaluation of individual cow milk for higher cheese-milk quality with increased cheese yield.
Cheese was produced in a series of experiments from milk separated in real time during milking by using the Afilab MCS milk classification service (Afikim, Israel), which is installed on the milk line in every stall and sorts milk in real time into 2 target tanks: the A tank for cheese production (CM) and the B tank for fluid milk products (FM). The cheese milk was prepared in varying ratios ranging from ~10:90 to ~90:10 CM:FM by using this system. Cheese was made with corrected protein-to-fat ratio and without it, as well as from milk stored at 4°C for 1, 2, 3, 4, and 8d before production. Cheese weight at 24h increased along the separationeffect of latitude on rates of disease in the indigenous population, the effect of immigration from southern to northern latitudes and the late winter-to-spring quarter season of birth effect, a modest but consistent finding that has survived mathematical challenges (Lewis and Griffin, [@B69]; Dalén, [@B24]; Pulver et al., [@B108]; Watson, [@B131]), and questions as to its relevance in the Southern hemisphere (McGrath and Welham, [@B79]), where the effect is much less robust.

One key environmental link between the epidemiological studies and related genetic/pharmacologic results is photic input (McGrath et al., [@B82]), a factor also of relevance to the melanotropin genes shown to be associated with psychotic disorders including schizophrenia (Severinsen et al., [@B114]; Miller et al., [@B90]; Demontis et al., [@B27]) and of relevance to pharmacological results that pertain


to the function of those genes (Miller, [@B88]). If photic input is the key variable, the less pronounced Southern hemisphere results actually bolster the season-of-birth theory because a much lower percent of populated land mass occurs at the higher latitudes in the southern hemisphere than in the Northern. Importantly, Brisbane, the most populous city in the McGrath et al. study of Australia ([@B82]), rests at latitude 27.5°S. Dublin, in contrast, is at latitude 53.4°N. A meta-analysis of published season of birth studies demonstrated that the effect does go up with increasing latitude (Davies et al., [@B25]). Furthermore, variation in overall schizophrenia incidence would be expected to vary with latitude, and a meta-analysis by McGrath and colleagues (Saha et al., [@B111]) demonstrated unequivocally that a gradient exists. This conclusionto have different light-responsive genotypes than those that evolved near the equator. Yet phenotypic plasticity can also be found, as evidenced by the well-studied effect of photoperiod on gestation, an effect which can not only determine coat color at birth but also neo-natal behavior (Hoffman, [@B50]; Reppert, [@B109]; Stetson et al., [@B121]; Weaver et al., [@B132]; Lee and Zucker, [@B68]; Nagy et al., [@B97]; Bellavía et al., [@B9]; Butler et al., [@B14]). Perhaps, then, the season-of-birth effect in schizophrenia could well be evidence of vestigial phenotypic plasticity in response to seasonally varying levels of light.

The approach taken in the present study was to analyze the correlation between rates of schizophrenia and a proxy measure for photic input, rainfall. Two countries were selected for inclusion, one at a more


(\<7%; personal communication from the former Yugoslavian Federal Hydrometeorological Institute), and more importantly, the variation in rainfall totals is unlikely to have changed the pattern of rainfall in any significant way. Data was digitized for the author by the Yugoslavian Hydrometeorological Institute and the mean annual rainfall values were calculated for 0.5 degree cells, constituting roughly 2000 sq. km. The boundaries of each cell were then superimposed on the schizophrenia hospitalization map. For each level of hospitalization rate, the corresponding cells for rainfall were tallied by the author and mean values were calculated. Where the boundary of a mapped schizophrenia hospitalization rate excluded a portion of a rainfall cell, the rainfall data was weighted by the landmass for the proportion of the cell that was included. To excludea given isohyet interval, weighted by its percent contribution to the catchment area. The correction for population distribution (1986 census) was carried out by weighting the rainfall data by the population (as a percent of the total population in the particular catchment area) in the towns with 5,000 or more residents and assuming that the remaining land area exhibited a uniform population distribution.

![**Rates of schizophrenia 1st admissions (left panel) vs. annual rainfall (right panel) in Ireland**. The 1st admissions digital plot represent means of the yearly values in the outlined health catchment area (S, MW, W, NW, MID, NE, E, and SE), calculated for 1982--1991 from data published by the Health Research Board for Ireland (Activities of Irish Psychiatric Hospitals and Units Dublin, Ireland). The annual rainfall digital


[@B15]).

With respect to the possible role of sunlight intensity in behavioral phenotypes, it has been proposed that cutaneous vitamin D generation may be involved in gestational effects that modulate the eventual development of schizophrenia (McGrath and Welham, [@B79]). In addition, other hormones of interest are produced in the skin in response to the intensity of the natural spectrum, including the melanotropin *alpha-MSH* (Farooqui et al., [@B36]; Lin and Fisher, [@B70]). Any matching CNS elevations of *alpha-MSH* via cues from the pineal would be expected to have important effects on learning and memory (LaHoste et al., [@B67]; Beckwith et al., [@B8]; Machado et al., [@B74]; Shen et al., [@B117]), the processing of sensory information (Miller et al., [@B89]) and feeding behaviors (Nahon, [@B98], [@B99]).

Phenotypic plasticity, genetic traits and gene-environmentD in gestation and subsequent schizophrenia may be complex, in that those with low maternal vitamin D are at increased risk of bearing offspring who become schizophrenic as are those with overly high vitamin D (McGrath et al., [@B80]).

What might be the relative impact of phenotypic plasticity vs. genetic traits of risk? For schizophrenia, the calculations show that the impact of the season-of-birth effect is not minor but rather roughly equivalent to that of family history of disease (Mortensen et al., [@B95]). For the northern hemisphere, the population attributable risk caused by a late winter/spring birth is on average 3.3% (Davies et al., [@B25]) but ranges to 10.5% in some locales (Mortensen et al., [@B95]), whereas the population-attributable risk if a parent or sibling was schizophrenic was 5.5%


rate of cannabis use in the Afro-Caribbean immigrant population may be somewhat higher vs. long term residents of the U.K. (Harvey et al., [@B46]) but may not be higher than rates in their home countries which have been reported to be already quite high (reviewed by Sugarman and Craufurd, [@B122]; Maharajh and Konings, [@B75]). However, other investigators found no elevation in drug use in Afro-Caribbeans in the U.K. as compared to non-immigrants (Cochrane and Bal, [@B19]; McGuire et al., [@B83]; reviewed by Coid et al., [@B21]).

Obviously, two of the major light-responsive physiological systems that would be strongly affected in Afro-Caribbean immigrants to the U.K. would be UV-induced vitamin D and the melanotropins. UV-induced vitamin-D would be expected to be particularly low for these individuals (Ford et al., [@B37];evidence for light-responsive melanotropin involvement can be found in an alternative mechanism of action proposed for antipsychotic drugs (Miller, [@B88]), based on the observed reaction between antipsychotic drugs and a neurotoxic catecholamine breakdown product to form the more innocuous pigment polymer, melanin. Consistent with this outcome, the melanotropin *alpha-MSH*, which enhances melanin formation and its sequestration, has been shown to normalize sensory gating in an auditory model of a schizophrenia endophenotype (Miller et al., [@B89]). In contrast, the melanotropin that inhibits the formation of melanin and its subsequent sequestration (*MCH*), inhibits effective sensory gating (Miller et al., [@B89]; Chung et al., [@B18]). Furthermore, nutritional imbalances that perturb melanogenesis can also elicit symptoms of psychosis (reviewed by Miller, [@B91]).

Conclusions {#s5}
===========

The correlations between epidemiological data and light levels are strong


promote “Sexual Reproductive Health Rights” in six developing countries.

The Department for International Development does not seem to be at all deterred in their support of the International Planned Parenthood Federation, but given their support for Marie Stopes International despite scandals associated with that organization, perhaps it is not entirely unsurprising. In 2016, Marie Stopes International had been forced to suspend abortion services due to concerns raised for patient safety, but the department still awarded that group and the International Planned Parenthood Federation £42 million to promote safe abortion in developing countries.

The horrific accusations against IPPF and the lack of any disciplinary action against the abortion group sets a troubling standard for organizations claiming to stand for reproductive rights. The continued support of the organization is concerning, as therewill look at it through your eagle eye perception. And so it is.

Beloveds, like a spider weaving a web, the intricate design of your life is woven with each moment of your Earth day. You sometimes work with the same pattern, going in circles, ending up at the same place and then beginning again. You know to what we are referring, correct? When will you open your eyes and look at what you have woven? When will you break free from the monotony of your design and look outside of the routine? You blindly accept what is as the way it must be until something happens to make you question it. Why not look at it before the tragedy, before the crisis, before someone else points it out?


When you open your mind to all possibilities, to miracles, to increasing your level of love and light in your life Dear Ones, you have taken the necessary first step in seeing who you truly are and what you are capable of. So we say to you break the mold. Lose the limitations. The world you live in now is changing with each of your linear moments. It is time to free yourself of your shackles. Take the lead and steer your own ship. Which direction will you go – That is where you will end up. So be it.

What happens when we are unable to meet someone else’s expectations of us? The idea of unconditional love is wonderful but perhaps as humans we are not capable ofthousand songbirds. I am the rush of a million waves in the ocean. I am the quiet snow on the mountaintop. I am the breeze brushing against my face. I am the children’s laughter coming from the playground. I am the words written on this page. I am peace. I am LOVE. I am joy. I am that!

July 6, 1975 was my last dialysis treatment of what was a hellish 8 months of undergoing 5-hour per day 3 times a week treatments. My kidneys had failed in November the prior year, landing me in the hospital for the entire month. I remember those days like it was yesterday. I had gone on vacation in October to visit my family in Kentucky before my baby was due as I


and killing. No, instead, amidst the icy, cold, depressing and alienating suburban landscape of Blackeberg, Sweden, a location populated by middle-aged alcoholics, sadistic kids, and uninterested parents and teachers, a grim and death-filled tale unfolds of two lonely "kids" that first develop a friendship with and then a consensual need for each other.Twelve-year-old Oskar (Kåre Hedebrant), who lives with his divorced mom in a bleak suburban circa 1982, is terrorized at school by a trio of future juvenile delinquents. One night as he takes his frustrations out by stabbing a tree – "Squeal like a pig. So, Squeal." – he is suddenly confronted by his new neighbor, a dark-haired and underdressed girl named Eli (Lina Leandersson) who smells as if she has less than good grooming habits. Shehas something to it that the film lacks, for minus the occasional artsy interludes (specifically: the dream and memory sequences involving a skating couple, the parents of Frannie (Meg Ryan) – which are also the best scenes in the entire film) the film is really not that much more than a well shot but misfired contemporary imitation of a typically sleazy mid-1970s Italian giallo film, only with a low body count and without the bad dubbing and killer in black gloves, the kind of film in which you know who the murderer is because (s)he always has the least screen time.In the Cut is available in two versions, an R-rated or an unrated DVD. The unrated might be slightly infamous for its close-up of a blowjob (an obvious


MySql.Data.MySqlClient.MySqlPool.GetConnection() +106
   MySql.Data.MySqlClient.MySqlConnection.Open() +293
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   BlogEngine.Core.BlogSettings.Load() +63
   BlogEngine.Core.BlogSettings..ctor() +25
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[TypeInitializationException: The type initializer for 'BlogEngine.Core.Web.HttpModules.ReferrerModule' threw an exception.]
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   System.RuntimeTypeHandle.CreateInstance(RuntimeType type, Boolean publicOnly, Boolean noCheck, Boolean& canBeCached, RuntimeMethodHandle& ctor, Boolean& bNeedSecurityCheck) +0
   System.RuntimeType.CreateInstanceSlow(Boolean publicOnly, Boolean fillCache) +86
   System.RuntimeType.CreateInstanceImpl(Boolean publicOnly, Boolean skipVisibilityChecks, Boolean fillCache) +230
   System.Activator.CreateInstance(Type type, Boolean nonPublic) +67
   System.RuntimeType.CreateInstanceImpl(BindingFlags bindingAttr, Binder binder, Object[] args, CultureInfo culture, Object[] activationAttributes) +1051
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   System.Web.Configuration.Common.ModulesEntry.Create() +39
   System.Web.Configuration.HttpModulesSection.CreateModules() +164
   System.Web.HttpApplication.InitModules() +28
   System.Web.HttpApplication.InitInternal(HttpContext context, HttpApplicationState state,(TPO Ab). Thyroid carcinoma patients had all been thyroidectomised and 94% additionally received radioiodine treatment. Appropriate measurements were obtained when thyroid hormones were non-hypothyroid on stable LT4 medication. Patient history, thyroid medication and other drugs, age, BMI, laboratory tests (FT3, FT4, TSH), antibody status (TSH-R Ab, TPO Ab in suspected thyroid autoimmune disease only) and thyroid imaging were documented.Table 1Characteristics of study group.ParameterUntreated Toxic adenoma n = 258Untreated Graves' disease n = 62LT4-treated carcinoma n = 141P valueGender female/male71% / 29%73% / 27%67% / 33%0.85Age years65.0 \[55, 74\]53.0 \[45, 62\]54.0 \[47, 62\]\<0.001BMI kg/m226.3 \[23.9, 29.5\]26.2 \[23.4, 27.9\]28.4 \[24.8, 32.2\]0.001Thyroid volume ml26.0 \[17.0, 43\]20.0 \[14.5, 29.8\]0 \[0, 0\]\<0.001Weight-adjusted LT4 dose µg/kg----1.69 \[1.52, 2.02\]--TSH within range/suppressed23%31%36%0.0277%69%64%FT4 within range/hyperthyroid96%86%74%\<0.0014%14%26%FT3 within range/hyperthyroid92%79%95%\<0.0018%21%5%FT3 pmol/l5.30 \[4.96, 5.81\]5.29 \[5.06, 6.08\]5.10 \[4.70, 5.70\]0.002FT4 pmol/l15.3 \[13.6, 17.0\]15.7 \[14.3, 18.3\]20.6 \[18.8, 23.2\]\<0.001TSH mIU/l0.25 \[0.10, 0.38\]0.29 \[0.01, 0.44\]0.15 \[0.02, 0.75\]0.81Deiodinase


\<1 ml was regarded as athyreotic.

Thyroid scintigraphy {#s0040}
--------------------

Technetium-99 m-Pertechnetate was used for thyroid scintigraphy. Imaging was performed using a parallel hole collimated gamma camera 20 min after application of 65--75 MBq of the tracer. In patients with larger thyroid nodule(s) (≥1 cm), it permitted to distinguish between hypofunctioning ("cold") and hyperfunctioning nodules ("hot nodules", toxic adenoma). Uptake measurements were also done in a few patients to differentiate Graves' disease from autoimmune thyroiditis.

Statistical methods {#s0045}
-------------------

Descriptive data are shown as median and interquartile range (IQR). TSH values were natural logarithmically transformed when indicated (lnTSH). Between-group comparisons for continuous variables were based on Wilcoxon's rank-sum test for two groups or Kruskal-Wallis test for three groups. Chi-squared test was used to compare frequency variables. Correlations were based on Kendall's tau rank correlation. To compare the curvilinear relationshipsfar less than that of untreated hyperthyroidism, presumably due to different T3 effects. Apart from TSH-associated risk, T4 increase has been directly linked to growth promotion of malignant tumours, as it enhances non-classical hormone signalling through the integrin receptor [@b0285], [@b0290]. A low ratio of FT3 to FT4 was independently correlated with various adverse outcomes, most strongly dyslipidaemia [@b0295].

Our findings contrast the thyroid-active (hyperthyroidism) and no-thyroid response to treatment (thyrotoxicosis), determined either by activation or lack of the physiological feedforward path on T3. Outcome measures cannot therefore rely on the assumption of response equivalence, which would require a consistent translation of the signalling chain from TSH to TSH receptor, FT4 and finally onto FT3. This questions the utility of TSH measurement alone as a clinical predictor in subclinical


- original draft, Visualization. **John E.M. Midgley:** Conceptualization, Writing - review & editing. **Rolf Larisch:** Investigation, Data curation, Writing - review & editing. **Johannes W. Dietrich:** Conceptualization, Writing - review & editing.

None.

[^1]: Data are median \[IQR\] or percentages. Significance was tested with Kruskal-Wallis or chi-square test, respectively. Range refers to the reference range.
n and || represents magnitude calculation and (pj_n - pi_n) represents vector subtraction.
I was wondering if there are any libraries that simplify this stuff for me. All I need is basically the following:
time-step particle position(x,y)

Does anyone have some suggestions for me please?

A:

I really like the pymunk physics library, a wrapper for the chipmunk physics library.
First of all, the library needs to be initialized:
import pymunk
pymunk.init_pymunk()
space = pymunk.Space()
space.gravity = (0.0, -100.0)

To achieve something the likes you have requested you have to create a Body and a Circle shape for each particle you wish to create.
mass = 1
radius = 14
inertia = pymunk.moment_for_circle(mass, 0, radius, (0,0))
body = pymunk.Body(mass, inertia)
x, y = random.randint(0, 200), random.randint(0, 200)
body.position = x, 550
shape = pymunk.Circle(body, radius, (0,0))
shape.sensor = True
space.add(body, shape)

The particles will not collide with each


safety and effectiveness,” she wrote, adding that those standards are always modernized and strengthened. “The FDA makes decisions based on consistent, rigorous scientific principles,” Walsh added.

Turner concedes that protocol changes aren’t inherently bad. They can be done for legitimate reasons, and study reviewers are trained to recognize deceptive protocol changes, which must be formally submitted for review. But some changes can invalidate a study just as surely as changing the goalposts in the middle of a game. “The relative timing [of protocol changes] is really important,” he said.

In fact, he and other FDA watchdogs say, the approval of flibanserin is just one of many examples of an agency that can sometimes seem more dedicated to serving the pharmaceutical industry’s interests than those of American consumers. And while themyeloid leukemia and malignant mesothelioma \[[@R17]--[@R19]\]. Some studies report that DPPIV acts as a tumor suppressor in melanoma, ovarian carcinoma, prostate cancer and cervical carcinoma cells \[[@R20]--[@R23]\]. In endometrial adenocarcinoma, DPPIV was expressed in normal endometrial glandular cells and EC \[[@R24], [@R25]\], although its contributions to tumorigenesis were not studied.

The present study investigated the relationship between DPPIV expression and malignancy in EC cells. Our results demonstrated that DPPIV overexpression induced cell morphological changes and stimulated cell proliferation, invasion and tumorigenesis *in vitro* and *in vivo*. These effects were abrogated by DPPIV knockdown and pharmacological inhibition by sitagliptin. DPPIV overexpression increased hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor A (VEGFA) expression to promote HIF-1α-VEGFA signaling. Our results indicate that DPPIV accelerated endometrial carcinoma progression and that sitagliptin may


assessed HIF-1αand VEGFA expression andsignaling after DPPIV overexpression or knockdown. DPPIV overexpression increased, and knockdown decreased HIF-1α levels in AN3CA cells. DPPIV can therefore alter VEGFA expression and activate the VEGFA signaling through HIF-1α. This is the first report of DPPIV modulating EC progression via HIF-1α-VEGFA signaling.

The potential link between the insulin/IGF-I signaling pathways and cancer has been the focus of much investigation over the last several years \[[@R53], [@R54]\]. IGF-I activityismediated by the IGF-I receptor (IGF-IR). IGF-IR gene expression regulation is mainly mediated at the level of transcription. Several studies have shown a correlation between IGF components and endometrial cancer risk \[[@R55], [@R56]\]. We found that IGF-1 expression increased in AN3CA cells overexpressing DPPIV, while IGF-1R expression was unchanged.

This study was the first to demonstrate that DPPIVand qRT-PCR ([Supplementary Figure 3](#SD1){ref-type="supplementary-material"}&[4](#SD1){ref-type="supplementary-material"}). Cells were divided into two groups: control (transfected with control virus) and DPPIV overexpression (transfected with DPPIV lentiviral vector). Cells were used in experiments within two passages of establishing DPPIV overexpression.

Cell proliferation assay {#s4_6}
------------------------

Ishikawa, HEC-1B and AN3CA cells were transfected with DPPIV overexpression or shRNA vectors; 96 h later, cells were trypsinized and centrifuged to obtain a pellet, and were seeded in 96-well plates (4×10^3^ cells/well) for 72 or 96 h. The AN3CA cell line was used for the DPPIV inhibitor experiment. Cells were seeded in 96-well plates (4×10^3^ cells/well) and treated 24 h later with different concentrations of the DPPIV inhibitor, sitagliptin phosphate (1, 2, 4 or 8 mM) (\#13252, Cayman Chemical, Ann Arbor, MI, USA), for 72 h at 37°C. Cell


gel and stained with ethidium bromide. *M* 100-bp ladder molecular weight markers; samples *1--16*, *P* positive control (Raji, an EBV-positive Burkitt lymphoma cell line), and *N* no-DNA negative control Fig. 2Mutations in pri-miR-BART2 and BART11. Structures of pri-miR-BART2 (**a**) and pri-miR-BART11 (**b**) are shown. *Black triangles* indicate single-nucleotide mutations. Mature miRNAs are indicated with *underlining*. Seed region of miR-BART11-3p is shown in *bold letters*

Discussion {#Sec7}
==========

The two mutations in the DNA fragment encoding miR-BARTs found in this study were not associated with any histological features of the lymphoma. In a previous study, miR-BART2-3p was not expressed in the serum samples of patients in the acute phase of infectious mononucleosis, whereas miR-BART2-5p was expressed abundantly \[[@CR15]\]. Therefore, the mutation in miR-BART2-3p identified in the present study is unlikely to be associatedconservation of EBV at least in a subset of lymphoma because there is no similar study.

AIDS

:   acquired immunodeficiency syndrome

ARL

:   AIDS-related diffuse large B cell lymphoma

DLBCL

:   diffuse large B-cell lymphoma

EBV

:   Epstein-Barr virus

ELD

:   EBV-positive DLBCL of the elderly

KSHV

:   Kaposi sarcoma-associated herpesvirus

LOW

:   low-grade B-cell lymphoma

miRNA

:   microRNA

MTX

:   methotrexate-related lymphoma

PBL

:   plasmablastic lymphoma

PCR

:   polymerase chain reaction

SNP

:   single nucleotide polymorphism

NKT

:   NK/T-cell lymphoma

HK conceived and designed the experiments. KS and HF performed the experiments. TH and HH contributed reagents, materials, or analysis tool. KS and HK analyzed the data and wrote the manuscript. All authors read and approved the final manuscript.

Acknowledgements {#FPar1}
================

Not applicable.

Competing interests {#FPar2}
===================

The authors declare that they have


maximum ridging latitude are consistent with the proposed effects on upper level atmosphere characteristics associated with Arctic amplification[@b13][@b17].

The 2015 poleward shift of the surface melting record in 2015, clearly indicates that improving our understanding of the impact of exceptional atmospheric conditions on the spatial distribution of extreme melting is crucial. Besides modulating the contribution of Greenland to sea level through the volume of meltwater production, the location of enhanced melting can influence ocean/ice interaction processes and ocean circulation[@b18], and bio-productivity, by altering salinity and temperature profiles of the surrounding ocean. Furthermore, the evolution of surface melting strongly impacts the Greenland\'s hydrological system, with implications for the englacial and subglacial systems, as well as ice discharge and dynamics[@b19]. Currently, several general circulation global climate models and Earth System models5B](#f5-jpr-10-417){ref-type="fig"}), and TNF-α (*P*\<0.05, n=4; [Figure 5C](#f5-jpr-10-417){ref-type="fig"}), compared to that in the sham groups. It also showed a significant decrease in IL-1β (*P*\<0.01, n=4; [Figure 5A](#f5-jpr-10-417){ref-type="fig"}) and IL-6 (*P*\<0.001, n=4; [Figure 5B](#f5-jpr-10-417){ref-type="fig"}) production in the MRS2395-treated cancer group and SB-203580-treated cancer group, but not TNF-α, compared to that in the DMSO-treated bone cancer pain rats.

Discussion
==========

In this study, we provide evidence for the first time that the activation of P2Y~12~R in spinal microglial plays an important role in the development and progression of CIBP, using immunohistochemical, pharmacological, and Western blot approaches. The new findings are as follows: 1) CIBP induced an increase in the expression of P2Y~12~R in spinal cord; 2) the intrathecal infusion of the P2Y~12~R antagonist MRS2395 suppressed the activation of microglia in CIBP; 3) the inhibition


ipsilateral side of bone cancer were partly increased after intrathecal injection of MRS2395 (400 pmol/µL, 15 µL, once daily) from days 9 to 12 postinoculation, but there was no significance between the cancer + DMSO group and the cancer + MRS group. Eight rats were used in each group.\
**Abbreviations:** I.t., intrathecal; PWTs, paw withdrawal thresholds; DMSO, dimethylsulfoxide; MRS, 2,2-Dimethyl-propionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethyl-propionyloxymethyl)-propyl ester.](jpr-10-417Fig1){#f1-jpr-10-417}

![Cancer-induced bone pain increases P2Y~12~R expressions in spinal dorsal horn.\
**Notes:** The levels of P2Y~12~R in the L4--L6 spinal cord were determined using the Western blot technique. (**A**) Gel panels show products from the L4--L6 spinal cord taken from normal rats, sham rats, and bone cancer rats 9 days after surgery. GAPDH was determined as loading control. (**B**) Normalized data of immune blot densitometry showed that the relativeof the Board. When will they learn to withhold their gratitude until after the action instead of giving it upon the promise of the action?
Let's be clear about what needs to change. The dysfunctional culture was driven by the internal politics of the John Stanford Center for Educational Excellence. It seemed that every decision that came out of that building was made for purely political reasons. The consequences were:

* The emergence of fiefdoms within the central administration
* The deliberate misinformation of the Board and the public
* Refusal to share information with the Board and the public
* Refusal to consider public input
* Refusal to allow public input
* Routinely breaking commitments to students and families
* Routinely breaking commitments to the Board
* Routinely violating policies
* Routinely violating state and federal law
*


from other high achieving kids, and the "saving" of things like Garfield's Marine Science and genetics classes -- was at least in part due to the efforts of Dr. E. -- in which case, I would happily add that to the plus list.

* Decisions that serve internal political purposes but do not serve students- The whole contract with TFA was driven by Dr. Enfield's desire to bring them in for her own personal reasons

The fact that TfA had nothing to do with the achievement gap ... means Dr. Enfield fraudulently skirted state law to get conditional certification for TfAers. (I suppose just like the BIG MONEY backers wanted ... hey Steve please clarify for us why you support this TfA fiasco?)

For the Board to actually enforce policy andthose numbers is", addition(numberA, numberB)
        print ""
        print "Press the Enter key to continue."
        raw_input('')
    elif choice == "2":
        print ""
        numberA = raw_input("Enter the first term: ")
        numberB = raw_input("Enter the second term: ")
        print ""
        print "The difference of those numbers is", subtraction(numberA, numberB)
        print ""
        print "Press the Enter key to continue."


   numberA = raw_input("Enter the dividend: ")
        numberB = raw_input("Enter the divisor: ")
        while float(numberB) == 0:
            print ""
            print "You cannot divide by zero. Please choose another divisor."
            print ""
            numberB = raw_input("Enter your divisor: ")
        print ""
        print "The quotient of those numbers is", division(numberA, numberB)
       print ""
        print "Press the Enter key to continue."
        raw_input('')
    elif choice == "5":
        while True:
            print ""
            numberA = raw_input("Enter the number you wish to find the square root of: ")
            if float(numberA) >= 0:
                break
            print ""


any condition warranty, representation or other term concerning aforesaid competition and prize which might otherwise be implied into or incorporated in these terms and conditions, is excluded to the maximum extent permitted by law.
15. These terms and conditions will be governed by the laws and subject to the exclusive jurisdiction of the courts of People’s Republic of China.

Did this article help you? If so, please tell me in a comment what do you think about it.support Assad, whose Alawite faith is an offshoot of Shiite Islam, the Journal said.

Iranian drones

Iran is also reportedly providing the Syrian regime with drones, the Daily Beast reported this week.

Some of these drones "were inspired by American technology and they're already playing a significant role in keeping Bashar Assad in power," the website reported.

Last week, Iran announced the replication of a U.S. drone that Tehran claimed it had captured in 2011.

Last Update: Wednesday, 20 May 2020 KSA 09:42 - GMT 06:42


year, whereas now each individual is consuming almost 24 kilos a year.

“No one used to eat much meat because our people could not afford it,” he said.

But it now falls to the government to bring production up to speed with the people’s increased spending power, Campos went on, citing the need for more advanced farming machinery brought from Argentina and Brazil through Mercosur trade agreements. Although, Campos admitted, scarcity of imported machine parts have made maintenance of equipment particularly tricky in 2014.

However, statistics show that Venezuelans are not only eating proportionately more, they are also traveling, studying, and purchasing more commercial goods than ever before.

President Maduro already detailed plans to expand tourism and transportation in the 2015 budget, and directed vast sums toward higher education and elderly pensionToday's OTB features an excerpt from my friend Vitaliy Katsenelson's recently published The Little Book of Sideways Markets. Vitaliy is CIO at Investment Management Associates, a value investment firm in Denver, and he is a prolific and engaging writer (you can find and subscribe to his articles at http://ContrarianEdge.com). I had the pleasure of writing the foreword to Vitaliy's book, and here is a brief excerpt:

"Markets go from long periods of appreciation to long periods of stagnation. These cycles last on average 17 years. If you bought an index in the United States in 1966, it was 1982 before you saw a new high – that was the last secular sideways market in the United States (until the current one). Investing in that market was difficult, to say


not writerow().
By using the correct function, it'll output your CSV file as you expect.
The issue you have with the lines showing on the same row in some editors is due to your lineterminator. You are setting it to \n, instead of the default \r\n

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"Restructured contracts and player transactions have saved the Detroit Lions approximately $27 million toward the 2013 cap, allowing them to make token signings in free agency." - Mike Ohara

So, we've shoved $27 million down the road TWENTY SEVEN MILLION, just this year alone. That's TWO SUPERSTAR PLAYERS we've pushed down the road JUST THIS OFFSEASON, and we STILL have no less than 5 holes on this team. That's horrible... You guys should want to puke, yet you jump for joy for over-paid scraps like Reggie Bush... Typical Lions fans...

When are you guys going to wake up and see what's going on?

Don't "So what?" me. Seriously, where did I say it was a good thing? I was just putting out an answer to Wags post. I didn't say anythingme that 2015/16/17 could well be barren restructuring years for this team.

wjb21ndtown wrote:

It's the support for Mayhew that gets me.

We've got to get to the playoffs in 2013 and make a deep run in 2014 IMO for that support to continue. If he pulls that off, I'll give him support for another rebuild cycle. Anything less and he needs to go.

You really think we have a shot at playoffs this year? I'm not insinuating anything by that, it's just an honest question as to where you see the state of this team.

March 19th, 2013, 5:00 pm

regularjoe12

Off. Coordinator – Joe Lombardi

Joined: March 30th, 2006, 12:48 amPosts: 3987Location: Davison Mi

Re: CJ restructured also.

wjb21ndtown wrote:

UK Lion wrote:

wjb21ndtown wrote:

$27 million just this offseason in future salary he's stolen from this team, and


not. The problem lies in the idea that we NEED to win and win now, cuz cap issues are not going to go away. Mayhew is going to be forced to bite the preverbial bullet and eat a lot of dead money for a year or two. He's post poning it as long as he can, but sooner or later the chickens are going to come home to roost and there will be no money left.

you think things were tight last year? lookout cuz a year is comming where we are going to cut guys wholesale with no money to sign replacements.

_________________2013 Lionbacker Fantasy Football Champion

March 19th, 2013, 5:33 pm

JL

Div 1 - Starter

Joined: December 13th, 2005, 2:09 pmPosts: 533

Re: CJ restructured also.

wjb21ndtown wrote:

Do you really want to saypublic office." That would have been January 2019, but the day before Biden announced his presidential campaign, the board changed the timetable.

The records have still not been released, and that fact is more pertinent now than ever due to recent sexual assault allegations against Biden by former congressional aide, Tara Reade. Reade alleges that Biden assaulted her in 1993, forcibly penetrating her with his fingers after she was asked to bring the then-Delaware senator his gym bag.

Reade claims that she filed a sexual harassment complaint with the Senate in 1993. She also says that she told three other staffers more generally about Biden's harassment, though not about the specific assault. Many believe that Biden's Senate records could confirm whether those claims are truthful.

As pressure mounts for Biden to


Hypertension attenuates the efficacy of hypoglycemic therapy for preserving coronary flow reserve in patients with type 2 diabetes.
Impairment of coronary flow reserve (CFR) in patients with type 2 diabetes has been generally demonstrated; however, there have been few studies investigating CFR in cases of relatively well-controlled diabetes, in distinction to the influence of hypertension. The purpose of the present study was to evaluate the influence of diabetes and hypertension upon CFR in relatively well-controlled patients. This study included 12 healthy controls (C group) and 57 patients with type 2 diabetes (DM) and/or essential hypertension who were divided into three groups as follows: patients with DM (DM group; n = 24), patients with essential hypertension (HT group; n = 15), and patients with both DM and essential hypertension (DM+HTMethods of sonographic cervical length measurement in pregnancy: a review of the literature.
In this review we give an overview of the methods and pitfalls in cervical length measurements. We compared the different techniques and investigated factors that influence visualization of the cervix. The data in this overview may be used to establish guidelines in clinical practice.


Family say move from Russia was for centre

A RUSSIAN couple moved to Worthing last year so their twins could benefit from care at the Camelia Botnar Children’s Centre.

Irina Scherbakova and Yuriy Staroselskiy, of St Thomas’s Road, Worthing, say the Goring centre, which is currently under threat due to a lack of funding, is a ‘very special place’ after their three-year-old twins Boris and Masha, three, joined last March.

Mrs Scherbakova said: “Some of our friends worked at the centre a few years ago which is how we found out about it.

“We browsed the internet and found a lot of information and some really good feedback so we decided to come and have a look.

“We were very surprised when we visited the centre as in Russia centres for children withroom for players and plunk down 40 bucks. I learn, quite soon, that I’m bad luck, a cooler. We plunk down another 60 bucks. And we ride it out for a good hour, conservatively milking our tiny stash as it grows and shrinks, watching others walk away after losing hundreds of dollars. But in the end we’re down to one 5-buck check on a $10-minimum table. We leave it for the dealer and thank him for a good time.

Dinner is at Hubert Keller’s Fleur de Lys. It’s one of the newer examples of the “chefs gone wild” trend in Vegas. There’s a prix fixe menu, so, aside from the pan-seared scallops to start, I leave it to the kitchen, and the meal becomes a journey itself.

Lisa Romerein

O by


grin, and watch the desert fade away. But one more tune of Frank’s comes drifting up, and it makes my insides twang:

I’ve got the world on a stringSittin’ on a rainbowGot the string around my fingerWhat a world, what a life,I’m in love …**

Snap.

*from “Fly Me to the Moon,” by Bart Howard**from “I’ve Got the World on a String,” by Harold Arlen and Ted Koehlerstart using this in warfare like with our knowledge of chemicals? This could have effects that last as long as humanity, because it is messing with how the body works. So playing God may not be the best idea.

1. Con begins his argument by asking why embryonic stem cells are used at all. I've already answered this in my R1 argument. Embryonic stem cells are more valuable, because they retain the ability to divide and make copies of themselves indefinitely. Adult stem cells are more limited and specialized than embryonic stem cells. They have the ability to make just one or two kinds of tissue, such as blood and immune system cells, brain or muscle cells. Adult stem cells also have a more limited capacity to replace themselves


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      <Filter>WinAPI</Filter>
    </ClCompile>
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   Cytomegalovirus (CMV), also known as human herpesvirus 5 (HHV-5), is a herpes virus classified as being a member of the beta subfamily of herpesviridae. According to the Centers for Disease Control and Prevention, CMV infection is found fairly ubiquitously in the human population, with an estimated 40-80% of the United States adult population having been infected. The virus is spread primarily through bodily fluids and is frequently passed from pregnant mothers to the fetus or newborn. In most individuals, CMV infection is latent, although virus activation can result in high fever, chills, fatigue, headaches, nausea, and splenomegaly.
Although most human CMV infections are asymptomatic, CMV infections in immunocompromised individuals, (such as HIV-positive patients, allogeneic transplant patients and cancer patients) or persons whose immune system has yet fully developed (such


Q:

Do EnChroma glasses "cure" color-blindness?

A few news stories have been circulating around about glasses that "cure" some forms of color-blindness:

CNBC - Glasses that let the color blind see color
Today.com - Watch these brothers' emotional reaction to seeing colors for the 1st time

Do these really work?  My understanding of colorblindness is that the color-seeing cones in the eye don't exist or don't work for certain colors, so I don't understand how that could possibly be fixed by glasses...

A:

As mentioned in an excellent Ars Technica article, they do treat (but not cure) one of the most common types of color-blindness (moderate red-green color blindness), but not all types of color-blindness. The type of people that these glasses help with are people whose red and green cones overlap more thanindividuals' serostatus, ranging from 52.5% among seronegative individuals (95% CI \[5.9, 76.1\]) to 81.9% among seropositive individuals (95% CI \[67.2, 90.0\]) \[[@pone.0175020.ref016]--[@pone.0175020.ref018]\]. In addition, analysis of the phase III trials of CYD-TDV indicated that an increased risk of severe disease is associated with breakthrough dengue infections in vaccinated seronegative individuals \[[@pone.0175020.ref019]\].

To examine the impact of a partially effective dengue vaccine, we developed a mathematical model of dengue transmission and vaccination. As the international use of the tetravalent dengue vaccine might be approved in the near future, evaluation of the potential impact that the dengue vaccine might have at the population level will be critical for optimizing public health strategies. There have been previous studies that have estimated the economic impact of dengue vaccines in Asia and South America,


unless indicated otherwise.

It is known that, soon after birth, infants are protected against dengue by high levels of maternal antibodies \[[@pone.0175020.ref043]\]. Thus, in our model, the population contains a resistant infant class of children under the age of one with maternal antibodies (*M*~1~) that wanes at rate *p*~1~. In addition, the population contains 10 other distinct age classes that represent individuals aged 1--4, 5--8, 9--14, 15--19, 20--24, 25--45, 46--49, 50--59, 60--64, and over 65. Transition rates among these age classes are independent of infection status and occur through aging at rate *p*~*k*~ (*k* = 1, ..., *11*). Within each age class, we incorporated 13 epidemiological classes. Detailed descriptions of these epidemiological classes can be found in [Table 2](#pone.0175020.t002){ref-type="table"}. Infected individuals are assumed to recover from primary infections atlost = ${\int\limits_{0}^{T_{f}}{\sum\limits_{k = 1}^{11}\left\lbrack \begin{array}{l}
{\Delta QALY(D_{DF},L_{DF},k)\left( \frac{dDF_{k}(t)}{dt} \right)} \\
{+ \Delta QALY(D_{DHF},L_{DHF},k)\left( {\frac{dDHF_{k}(t)}{dt} - \frac{dDeath_{k}(t)}{dt}} \right)} \\
{+ \Delta QALY(D_{Death},L_{Death},k)\left( \frac{dDeath_{k}(t)}{dt} \right)} \\
\end{array} \right\rbrack}}dt$

Results {#sec010}
=======

We calculated the equilibria for the annual dengue infection incidence in the absence of vaccination (1,060 per 100,000) and the annual symptomatic dengue fever incidence (539 per 100,000), which were comparable to empirical estimates \[[@pone.0175020.ref036], [@pone.0175020.ref037], [@pone.0175020.ref047]--[@pone.0175020.ref049]\]. The annual DHF incidence in Yucatán, Mexico was estimated to be 12 per 100,000 \[[@pone.0175020.ref048], [@pone.0175020.ref049]\]. Accordingly, we estimated the total cost of dengue per year in Yucatán, Mexico to be \$1.86 million for the health care system and \$3.41 million for society.

For vaccination scenarios, we assumed that vaccines were given to individuals of the target ages (i.e., ages 9--45 years old). As baseline parameter values, vaccination rates


to be Triangle (\$125, \$250, \$375).](pone.0175020.g003){#pone.0175020.g003}

![Cost-effectiveness acceptability curves.\
The curves show that dengue vaccination in Mexico is cost-effective at different cost-effectiveness threshold values. The cost-effectiveness acceptability curves from healthcare and societal perspectives are shown when the cost of vaccination is based on the triangle distribution with a mean value of \$250, i.e., Triangle (125, 250, 375).](pone.0175020.g004){#pone.0175020.g004}

In order to examine how our results change with different vaccine coverage levels, we performed 5,000 Monte Carlo simulations for probabilistic sensitivity analyses with various vaccine coverage levels (20% and 40%) (Figures A and B in [S1 Appendix](#pone.0175020.s001){ref-type="supplementary-material"}). In this analysis, the probability of cost-effectiveness is likely to be higher with lower vaccine coverage than with higher vaccine coverage, as long as a relatively low threshold is used such as \$10,307 GDP per capitadengue vaccination. This is the first cost-effectiveness analysis of dengue vaccination in in Yucatán, Mexico. We examined the potential impact of dengue vaccination on reducing the incidence of dengue infection by simulating an age-dependent dynamic model of dengue transmission with vaccination. Our work can inform policymakers of the price at which dengue vaccination becomes cost-effective and reveals that dengue vaccination has the potential to significantly reduce the number of severe infections and dengue-related costs. Thus, introducing a dengue vaccine in in Yucatán, Mexico can effectively reduce the health and economic burdens associated with dengue infections.

Supporting information {#sec012}
======================

###### Supplementary figures and tables.

(DOC)

######

Click here for additional data file.

[^1]: **Competing Interests:**The author has declared that no competing interests exist.

[^2]: **Conceptualization:** ES.**Data curation:** ES.**Formal analysis:** ES.**Funding acquisition:** ES.**Investigation:** ES.**Methodology:** ES.**Project administration:**


winning group throughout the game. Note that this approach is very different from adaptation through evolution studied previously in the context of the minority model [@Paczuski].

Our main observation is that networks with small $K$ ($K<5$) adapt to a certain degree to the changes in the capacity level. In particular, networks with $K=2$ show a tendency towards self–organization into a phase characterized by small fluctuations, hence, an efficient utilization of the resource, even for relatively large variations in the capacity level $\eta(t)$. Note, that in the Kauffman nets with $K>2$ the dynamics of the system is chaotic with an exponentially increasing length of attractors as the system size grows, while for $K<2$ the network reaches a frozen configuration. The case $K=2$ corresponds to a phase transition in the dynamical properties$K$, a set of strategies was chosen for each agent randomly and independently from a pool of $2^{2^K}$ possible boolean functions, and was quenched throughout the game. In all simulations we used $S=2$ strategies per agent. Starting from a random initial configuration, the system evolved according to the specified rules. The duration of the simulation $T_0$ was determined by the particular choice of $\eta(t)$. Depending on the amplitude of the perturbation, we run the simulations for $10$ to $20$ periods, and usually used the data for the last two periods to determine $\sigma$.

= 2.50in

Figure \[fig1\] (a) shows a typical segment of the time series of the attendance $A(t)$ for a system of size $N=1000$, network connectivity $K=2$, and a sinusoidal perturbation $\eta_1(t)$. One can see that the system is


world in pursuit of simplicity and freedom. Several continents, adventures, and misadventures later, I'm back in Kansas City holding to the stubborn belief that you can have both roots and wings.

About Me

Hello! I'm Mariah. I'm a seeker of contentment, yet a tireless wanderer full of wonder. I like to cook homemade curry, travel the world, and write about things like social justice and community. It’s my goal every day to learn and love with abandon. Join me on the journey!ashamed of it, and so they tried to conceal it. They had determined, once and for all, that their monstrous disproportions were, in reality, true proportion, and their inconceivable ugliness was beauty. They were strangers on this planet, but they refused to admit it. They played at being perfectly at home. He caught a glimpse of his own reflection in a shop window. He was no different. Identical, exactly the same likeness as that of the monsters. He belonged to their species, but for some unknown reason he had been banished from their company. They had no confidence in him. All they wanted from him was obedience to their incongruous rules and their ridiculous laws. Ridiculous only to him, because he could never fathom their intricacy and their


coincidence that the vast, vast majority of my memories of the book – and I only read it the morning of this writing – came from the final third, and so I was at least thirty or forty pages too early each and every time I went to search for a particular quotation.

Still, the Tenant is a labyrinthine and disquieting exploration of interaction and madness, with the ultimate conclusion that the two may not be all that far off. Though not the flawless gem that Ligotti's or Lovecraft's finest tales are, this is still one of the bleakest novels I've read. Beginning and ending on the same interminable note, The Tenant is a novel likely to haunt the back of your mind for weeks, coloring your every conversation.Upon finishing, you may cast about for what makes you you. And, if Topor's to be believed, that search will be at once brief and endless, fruitless and hopeless…

[A final word of caution: as I've no doubt made clear, Thomas Ligotti's analyses of the story in The Conspiracy Against the Human race is fantastic, and is – I believe – published in similar form in the introduction to the Centipde Press edition of the novel (which I, alas, do not own). That being said, his analysis of the story is filled with spoilers and reveals the end. While this is far from a twist based story, I would still advise reading the novel before the analysis.]

Monday, September 26, 2011

Linger Fiction has, it seems, stopped lingering, a damn shame


because they published a damn huge number of damn good flash tales. Of course, among their archives lurked (lingered?) my very own The Metamorphosis of Jane Doe, a story that is once again homeless. Alas. I've not totally made up my mind about what to do with the story yet, though I am considering posting it here as a once-published writing sample for anyone curious.

Tuesday, September 20, 2011

Thomas Tessier's Wicked Things opens with insurance investigator Jack Carlson learning he's to go to the town of Winship to investigate a run of accidental deaths. When there, he soon discovers that things are not as they seem. Alas, exactly what they are like is never quite revealed. I'd say that this review has SPOILERs, but, to be honest, that wouldsecond half, kicked off by the murder of Jack's initial love interest and the potentially scheming insurance agent, seeks to monopolize on the groundwork laid in the first half. This might have worked better if any groundwork had, in fact, been laid. As is, when a secondary character starts rambling about how every single official in Winship – even the churches. Especially the churches. (p. 117) – are "like the Nazis, man," (p. 117) she doesn't so much come across as prophetic as she does unhinged. So how does Jack investigate all these people and even the churches? Why, by bumbling around accomplishing nothing and waiting for someone to hand the information to him, of course! I shouldn't give the impression that he's totally inactive, though. Jack does,


the newspaper mogul so he can win office as the biggest badass cop in town (and to not be outdone in the category of being complete psychotic), rounds up a fellow Vet, and they proceed to torture and execute Howie and his pals.

The characters are sketches, but much of Scramburg does prove entertaining in a slasher-esque, stuff blowing up kind of way, the allegory's not bad, and it's refreshing, after the main novel, to read something with at least the pretences of a fast pace. But there's one fatal flaw in the heart of Scramburg: the reader can never, even for a moment, fail to see Tessier's hand guiding everything towards the largest blast. Perhaps a part of this is that the novel's divided into neat sections, eachof which focuses on one side and shows not a single setback for them until Tessier decides he's exhausted their possibilities for mayhem and switches to someone else in turn maiming/slaughtering the first group. But whatever the reason, not a single action here feels organic. How does Howie think terrorism's going to help him, exactly? Why do his relatively normal friends go along with this plan? Why, if the cop is trying to gain publicity, does he quietly kill Howie rather than arresting him? Why do Howie and his pals come back as ghosts to kill their killers, when the story up until then has had not the slightest hint of the supernatural? As far as I can tell, the answer to most of those questions is to


larger and more immediate problems. When it comes to the ultimate issues of responsibility and to where the blame for the catastrophe's of the tale fall, Miéville's content to let the reader draw their own conclusions. The central questions of the novel – the morality of language, lies, and authority – are presented from different sides (language is the continuation of coercion by other means squaring off against [language is] cooperation), and the only hint Miéville gives about the validity of either side is that they weren't as contradictory as they sounded. (p. 316)

Embassytown is often a punishingly hard read, especially in its opening. The scenes and information shown there are all vital later, but their order often feels almost intentionally difficult to parse. As Avice says ofsoon discover they've little physical chemistry and fairly quickly gave up on sex. (p. 38) Other relationships get even less of a yearning description. Potential attraction between Avice and another character are merely implied by a never unsubstantiated reference of "some prurience." (p. 204) Despite all of that, however, there is a faint romanticism to Avice's narration – perhaps even to Miéville himself, back on the other side of the page – as is always evident in her later dealings with CalVin and her ruminations about a fraternity of those who once loved [her], or still did? (p. 242) Such a thing is like as not more a product of Avice's occasionally quite arrogant mind than of the other characters', but the existence of such ruminations in and


with exactitude. Ultimately, however, their principal reason is analogous to that of more healthy individuals: to experience the pleasurable emotions and sensations that make life worth living over and against those and emotions and sensations which put in question the worth of life—physical or mental illness (either due to genetics, traumas, or pernicious environmental conditions), tragic events that cast a shadow over an individual’s existence, a general lack of existential satisfactions, and other types of awful experience.

Even if the genetics, traumas, and environments that drive us to alcohol, drugs, or dark fiction are not obvious, they may nevertheless be in play all the same. What makes nightmares? More to the point, what make an individual dwell with a morbid excitement over his nightmares? And what makes someone wishdeprived without it and their bodies and minds would tremble with craving for depraved imaginings. Thus, in my opinion, if your life—or some portion of your life—depends on the consumption of fiction founded on the darkness of the world for it to be worth living, then there is definitely something wrong with you both as a conventional and a peculiar being.

When I was a child reading horror comic books, I was told by my parents that a priest was coming to visit our house. Immediately, I gathered up my horror comics and him them under the cushion of one of the living room sofas. When the priest entered the house, he was invited by my parents to sit down. Of course, he sat upon the cushion of the


to The Agonizing Resurrection of Victor Frankenstein, “will require further adjustments in order to nudge its nature closer to that untainted rationality that Moreau values above all else.” He wanted to make men, not silly sops—brutes on the make that will as likely tear out their fellow creatures’ throats as they are to beg pathetically for what they want. Such a gesture implies the capacity for a range of actions endemic to human beings what it meant to be human, something that did not include the courtly sentimentality that the manwolf displays. Moreau’s House of Pain was intended to torture animals into becoming human, to mutilate and brainwash them into the kind of heartless because that Wells portrayed Moreau as exemplifying.

Now, my wont has never been to producearguments surrounding them and quotation of them – do you believe in determinism? If so, how can you reconcile that with daily life?

I don’t argue that determinism is true in Conspiracy. To do so would be futile. I do discuss the subject because it’s related to other matters in the book, especially the reality or unreality of the “self.” Whether our thoughts and behavior are determined or free is of no consequence if, as Metzinger argues, no selves exist or have ever existed and there is nothing that can be determine or free. I think the question of the self is far more interesting because scientists are getting closer to being able to test how our perception of ourselves, other people, and the world in general are formed.


born. Interestingly, those who believe that life is worth living often begin making their case by pointing out the goodness of ice cream. If you’re not diabetic, lactose intolerant, obese, or have any number of other ailments, ice cream is indeed very good. Given the link made between antinatalism and murder or genocide, I hope that the replies I’ve given to this question demonstrate that no such link exists. An antinatalist may have a passion for murder and genocide, but this is by no means an element of antinatalism. Murder and genocide are two phenomena that antinatlists would offer as reasons for why it would be better never to have been born. I hope the logic of this statement is evident.

13. Let's end on a happy note. What'sthe most enjoyable thing you did this week?

Friday, September 2, 2011

Then I turned on all the lights in the room, lighted a cigarette (we all like to pose a little now and then), and sat down on the bed to await my capture. (p. 111)

Though Sam Spade, famous for his starring role in the Maltese Falcon, might have a higher profile, it's the Continental Op that narrated the lion's share of Dashiell Hammett's fiction, including Red Harvest, The Dain Curse, and the bulk of the man's short fiction. Containing seven stories written between 1924 and 1930, the The Continental Op collection from Black Lizard is filled with tales that perfectly show one of the genre's best on his home turf.

Mystery – the hodgepodge bookstore section for mysteries, crime,


and thrillers, that is – is at its heart a rational genre. To boil the genre down to a single glib sentence, the genre is the solving of puzzles. At the opening of the story, the detective, and the reader, is confronted with a situation that makes no sense. Then, like the Scooby gang demasking another supernatural ghost to find a middle aged man, the detective makes sense of the clues and replaces impossibility with a logical procession of events. Any in genre story by Poe, Doyle, or any of their authorial descendants, begins with a series of incomprehensible clues and ends with motive, miscreant, and method all neatly tied up and – if the author's good at what they do – no disappointing coincidences or absurdities remaining.

Dashiellsame page: [he was] about five eight inches tall, would weight about a hundred and seventy pounds, had brown hair and eyes, a dark complexion, a flat, broad face with his cheekbones, and wore a blue suit, gray hat, tan overcoat, black shoes, and a pear-shaped pearl tie-pin. (p. 252)

The newest of these stories is eight decades old, and it's true that their levels of gore and profanity feel tame to a modern audience. Their core, however, feels anything but. Hammett's grasp of atmosphere and pace is excellent here, and his ability to build tension is unmatched. After a classic Hammett moment of false perceptions, The House on Turk Street becomes a deadly game of cat and mouse in an unlit house. Other stories, too, are prone to


Q:

Javascript: timeupdate end function

I'm trying to trigger a single alert event at 15 seconds on a 45-second video file. I'm able to initiate using the function below, how would I cause the function ('the alert) to trigger only once.
var video = document.getElementById("media");
video.addEventListener('timeupdate', function(e) {
    if (e.target.currentTime == 15000);
    alert("Hello! I am an alert box!!");
}, false);

A:

The above code would not work because, for every timeupdate, you cannot ensure that the current time will give you 15000(It should be 15 / 15.000 instead, right, current time used in seconds). It might not be triggered.
Instead, use setTimeout function in javascript, like this:
    video.play();
    var to = setTimeout(function(){
    alert("Hello! I am an alert box!!");},15000);

To stop the timeout,follow a venerable philosophical tradition that insists on a tight connection between values and preferences, values-based preferences cannot be completely understood in terms of preferences alone.21 Whereas preferences are typically construed as subjective comparative evaluations that may generate no reasons for action, a value commitment that grounds a values-based preference is a robust pro-attitude that generates reasons for action.22, 23 As Daniel M. Haybron and Valerie Tiberius state, "to value something and not merely prefer it is to see it as generating reasons for you-as tending to justify responding in certain ways to it and limiting how you might reasonably respond to it."24 While values-based preferences may not be revealed through choice, and might be described as a subset of second-order or meta-preferences, they can never be explained


ways to resolve dynamic choice problems, this article focuses on one strategy – resolute choice – that was originally developed by Edward F. McClennen and further refined by David Gauthier.28, 29 On this account, Joe is confronted with a choice among various consumption plans. Every plan specifies a complete implementable sequence of consumption choices over time.30 On the assumption that Joe is properly informed of the alternatives and exercises good judgement, how is Joe to choose a plan? Joe compares and evaluates the prospects or expected outcomes of each plan and judges such outcomes to be either acceptable or unacceptable. In this case, we will assume that acceptable consumption plans are compatible with Joe's value commitment to his own health while unacceptable plans are not.31 Other things beingequal, Joe's commitment picks out acceptable patterns of consumption, healthy patterns, from those that are not (unhealthy patterns). During the deliberative process of selecting a particular plan or set of acceptable plans, Joe evaluates the terminal states of affairs associated with feasible consumption plans and his evaluation is based on an interval measure defined on these states (a utility function or expected utility function).32 For Joe, acting on an acceptable plan requires adopting a strategy for consuming goods and services over time. McClennen and Gauthier identify three distinct strategies available to Joe: (1) myopic (2) sophisticated and (3) resolute choice. Joe chooses myopically when he embarks on a 10 plan but executes another plan that seems best to him at the time of choice, without any consideration as


to the likelihood that his choice will continue to seem best to him in the future. By contrast, if Joe manages to look ahead and consider what will be best for him in the future, then he is a sophisticated chooser. For example, he might decide to reject a presently attractive plan, when he predicts that he will come to prefer the prospect of an alternative plan. Finally, Joe might opt to be a resolute chooser. This mode of choice subordinates posterior choices to prior choices. Joe chooses an acceptable plan at the outset, commits to it, and holds to this plan rather than considering later on what would be the most attractive option to choose. So, which strategy should Joe pursue? Should Joe be myopic, sophisticated, orprospects at the time of choice. With this information, Joe concludes that choosing a plan at the outset and sticking to it – without taking further action – is infeasible for a person like him. Resorting to a sophisticated strategy, Joe proceeds to drink a liter of water before entering the cafeteria, believing that, while drinking the water will cause discomfort, it will also reduce his dehydration, the main cause of his cravings for the unhealthy options. With this strategy in place, Joe is able to follow through on his original plan – to ultimately select the healthy option over the unhealthy one. Alternatively, Joe could be a resolute chooser. Joe chooses his acceptable plan at the outset – a plan that is compatible with his value commitment


of cake this time but a piece of fruit on all other occasions. When no choice is imminent, Joe prefers fruit on every occasion. Suppose also that when choice is not imminent Joe prefers 100 pieces of fruit to 100 slices of cake. If Joe chooses based on his proximate preferences, then taking all of his choices into account, Joe will choose slices of cake on each of the 100 occasions. This mode of choice does not best realize Joe's concerns as viewed at any time because were Joe to choose on the basis of his values-based preferences, Joe would choose 100 pieces of fruit, and whether or not a choice is imminent, Joe prefers 100 pieces of fruit to 100 slices of cake. This example presumes thataddictive drugs could ever be justified. Other things being equal, helping to satisfy this problematic preference would seem to be bad for the individual. Promoting the satisfaction of preferences, whether revealed or true, is never a value-neutral 21 decision. Invariably, interventions that promote the satisfaction of some preferences over others face some version of the normative challenge. Finally, the methodological challenge states there is no psychological foundation for ascribing agents with stable and context-independent true preferences. Responding to this challenge requires either arguing that there is no need for such a foundation, or that there may be an adequate psychological foundation for true preferences. Following the latter pathway, Hausman has argued that your average Joe-in-the-cafeteria has the capacity for context-independent reasoning, and that he himself can affirm or


own health, is not that he makes one or two healthy choices, but that he chooses over time in a manner that expresses his value commitment, which is normative, affective, and stable. The foregoing analysis reveals significant lessons for behavioral economists and philosophers of economics. From the purview of values-based preferences, behavioral economists risk overemphasizing the normative significance of true preferences. There are circumstances when agents would do less well – by their own subjective standards – to satisfy their values-based preference than to satisfy some particularly strong (proximate) preference that the agent possesses in a specific choice situation. This result complicates the project of designing and deploying interventions, such as nudges and boosts. After all, even if such interventions were ethical and efficacious, and behavioral economists hadKnetsch and Richard H. Thaler, 'Experimental tests of the Endowment Effect and the Coase Theorem', Journal of Political Economy 98 (1990): 1325-1348; David A. Schkade and Daniel Kahneman, 'Does Living in California Make People Happy? A Focusing Illusion in Judgements of Life Satisfaction', Psychological Science 9 (1998): 340-346; Amos Tversky and Daniel Kahneman, 'The Framing of Decisions and the Psychology of Choice', Science 211 (4481) (1981): 453-458. 13 See Cass R. Sunstein and Richard H. Thaler, 'Libertarian Paternalism is not an Oxymoron', The University of Chicago Law Review 70 (2003): 1159-1202; also see Colin Camerer, Samuel Issacharoff, George Loewenstein, Ted O'Donoghue, and Matthew Rabin, 'Regulation for Conservatives: Behavioral Economics and the Case for 'Asymmetric Paternalism.'' University of Pennsylvania Law Review 151 (2003): 1211-1254. 14 Till Grüne-Yanoff, 'Nudge versus


commitments are both reasonable and ubiquitous, they are also tangential to the purpose at hand, which is to analyze value commitments that yield prudential benefit. See Amartya Sen, 'Rational Fools: A Critique of the Behavioral Foundations of Economic Theory' Philosophy & Public Affairs 6 (4) (1997): 317-344. 26 See Hausman (2012) op cit. 27 See Chrisoula Andreou, 'Dynamic Choice,' The Stanford Encyclopedia of Philosophy, Edward N. Zalta (Ed.) (2016), URL = https://plato.stanford.edu/archives/spr2017/entries/dynamic-choice/ 28 McClennen op cit., and Gauthier op cit. 29 My exposition of this account will be informal. For a formal version, the reader should see McClennen op cit. 30 For each choice point, a plan specifies a unique choice among those available given the choice it specified at the preceding choice point, if any, and eacha note on a table to begin. Not only is the story decent, but it’s a good way to tease people and get them prepared to either sub or drop Crowns on the DLC itself. Sneaky, ZOS, very sneaky. The only downer about this quest is that it’s a LOT of running around, and if you’re on a relatively new character, it can be a chore because the waypoints aren’t unlocked yet.

There are a load of new mobs in Sotha Sil’s domain. Some of which are variations on what we’ve seen in the previous trial, but others are brand new to the game - including humanoid mechanisms that are on guard and will try to take you out simply for being there in the CWC. The new delves


is rather small. Even for hundreds of electrons, Hartree-Fock or multi-reference Hartree-Fock (HF) nodes lead to impressive accuracy when used within QMC. The fixed-node QMC calculations typically provide about 95% of the correlation energy in real systems [@qmcrev] such as molecules, clusters, solids, etc.

At a more fundamental level, knowledge of the exact node enables one to eliminate the fixed-node bias completely, and the exact energy can be calculated in time which scales as a low-order polynomial in the number of particles. Therefore elimination of the fixed-node error remains one of the intriguing possibilities for employing QMC to attack a number of important many-body problems which require accuracy beyond a few-determinant Hartree-Fock nodes.

Let us assume a system of spin-polarized electrons described by a real wavefunction $\Psi(R)$ where $R$ denotesthe electron spatial coordinates. The exchange of an electron pair with labels $i,j$, denoted as $P_{ij}$, gives $\Psi(R) = - \Psi(P_{ij}R)$. Consequently, the antisymmetry implies that there exists a subset of electron configurations, called a fermion node, for which the wavefunction is zero. Let us eliminate the regions in which the wavefunction vanishes because of other reasons (eg, external potential); then the fermion node is given by an implicit equation $\Psi(R)=0$. In general, the fermion node is a ($ND$-1)-dimensional manifold (hypersurface) assuming that we have $N$ fermions in a $D-$dimensional space. The fermion nodes of small systems, mostly atoms, were investigated in several previously published papers [@node1s2s; @dario04; @jbanderson75; @andersp; @lesternode]. The general properties of fermion nodes were analyzed in an extensive study by Ceperley [@davidnode] which included