If you’re a hockey fan in Middle Tennessee, you’ve been caught up in this ridiculous lockout. Since September 15, the NHL and NHLPA have been embroiled in continuous posturing, lewd remarks and mud slinging. All to lose more than three months of the scheduled season only to come to an agreement in the wee hours of the morning on Sunday, January 6.

In short, it was billionaires fighting millionaires. And, during a recession, that doesn’t go over very well.

Some fans are irate. Okay, most fans are irate. The franchises in Canada and the northern states will be fine. Their fans will come back to the rink and, if not, they’ll be replaced by other fans. Here in a non-traditional market like Nashville, however, the turn out may be scarce.time. It’s because there’s a common thread that transcends occupations, hobbies, passions, music, religion and politics. Do you really want to walk away from all the friends you’ve made over the years?

“I love the sport no matter what,” longtime Nashville season ticket holder Brian Binkley said. “College, AHL, NHL, whatever. But mainly, it’s the people. You sit with people at the games and you kind of grow up with them. That’s the biggest reason. It’s more of a family environment. If I walked away, I would really miss that.”

Nobody wants to support “the bad guys.” And if you go to a game at 501 Broadway, you may think you’re doing just that. But remember, there’s love there too. There’s love and passion and camaraderie from all those around


// CodeMirror, copyright (c) by Marijn Haverbeke and others
// Distributed under an MIT license: http://codemirror.net/LICENSE

(function(mod) {
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        state.indentationDiff = Math.min(indentation - state.indentation, 4);
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    innerMode: function(state) {
      if (state.block == htmlBlock) return {state: state.htmlState, mode: htmlMode};
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CodeMirror.defineMIME("text/x-markdown", "markdown");

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treatment with standard antiretroviral therapy (ART) and chemotherapy at the UCI. We will collect saliva, plasma, and KS lesion samples serially over the course of therapy up to one year, and we will quantify HHV-8 in specimens using polymerase chain reaction (PCR), including novel PCR assays to evaluate specific HHV-8 gene mRNA in tumors. We will then test whether levels of HHV-8 replication in these various anatomic sites are associated with clinical presentation or predict treatment response. This proposed study will advance our understanding of the biologic role of replicating HHV-8 and lytic gene expression in established KS disease and could make significant contributions to KS care. If we find that levels of HHV-8 replication predict treatment response or relapse, HHV-8 may be a useful biomarker and could


April 2015, Volume 21, Number 2

Global Migration

France. France's Prime Minister Manuel Valls in January 2015 began a debate on "apartheid" in France, saying that even though the French constitution says all citizens are equally French, there are stark differences between French citizens based on race, ethnicity and religion. Valls said that France suffers from "territorial, social, ethnic apartheid."

On January 7, 2015, French-born terrorists attacked the satirical magazine Charlie Hebdo, killing staffers for what they said was desecration of Islam.

In a bid to better integrate central cities and suburbs with immigrants and their children, Paris Metropole will be created in 2016 with a regional council to oversee seven million residents. The question is whether people living in suburbs beyond the circular Peripherique that rings Paris will identify with thoseYes to the Freedom of Expression" shouts in a megaphone during a protest against the mandatory wearing of face masks in Paris. Masks, which were already compulsory on public transport, in enclosed public spaces, and outdoors in Paris in certain high-congestion areas around tourist sites, were made mandatory outdoors citywide on August 28 to fight the rising coronavirus infections AFP via Getty World news in pictures 28 August 2020 Japanese Prime Minister Shinzo Abe bows to the national flag at the start of a press conference at the prime minister official residence in Tokyo. Abe announced he will resign over health problems, in a bombshell development that kicks off a leadership contest in the world's third-largest economy AFP via Getty World news in pictures 27 August 2020 Residents


news in pictures 23 August 2020 People carry an idol of the Hindu god Ganesh, the deity of prosperity, to immerse it off the coast of the Arabian sea during the Ganesh Chaturthi festival in Mumbai, India Reuters World news in pictures 22 August 2020 Firefighters watch as flames from the LNU Lightning Complex fires approach a home in Napa County, California AP World news in pictures 21 August 2020 Members of the Israeli security forces arrest a Palestinian demonstrator during a rally to protest against Israel's plan to annex parts of the occupied West Bank AFP via Getty World news in pictures 20 August 2020 A man pushes his bicycle through a deserted road after prohibitory orders were imposed by district officials for a week to containKennedy Space Centre in Florida. The mission is part of the USA's largest moon to Mars exploration. Nasa will attempt to establish a sustained human presence on and around the moon by 2028 through their Artemis programme EPA World news in pictures 29 July 2020 A woman refreshes herself in a outdoor pool in summer temperatures in Ehingen, Germany dpa via AP World news in pictures 28 July 2020 Malaysia's former prime minister Najib Razak speaks to the media after he was found guilty in his corruption trial in Kuala Lumpur AFP via Getty World news in pictures 27 July 2020 North Korean leader Kim Jong Un poses for a photograph after conferring commemorative pistols to leading commanding officers of the armed forces on the 67th anniversary of


the "Day of Victory in the Great Fatherland Liberation War". Which marks the signing of the Korean War armistice KCNA via Reuters

People with albinism are often targeted under the belief their body parts are particularly potent in rituals.

Known as “zeru zeru” or ghosts, their condition is heavily stigmatised and families who consider it a curse have been known to kick relatives out of their homes.typename interval_lib::unprotect<interval<T, Policies> >::type I;
  T const &yb = interval_lib::user::is_neg(x.lower()) ? y.lower() : y.upper();
  T n = rnd.int_down(rnd.div_down(x.lower(), yb));
  return (const I&)x - n * (const I&)y;
}

template<class T, class Policies> inline
interval<T, Policies> fmod(const interval<T, Policies>& x, const T& y)
{
  if (interval_lib::detail::test_input(x, y))
    return interval<T, Policies>::empty();
  typename Policies::rounding rnd;
  typedef typename interval_lib::unprotect<interval<T, Policies> >::type I;
  T n = rnd.int_down(rnd.div_down(x.lower(), y));
  return (const I&)x - n * I(y);
}

template<class T, class Policies> inline
interval<T, Policies> fmod(const T& x, const interval<T, Policies>& y)
{
  if (interval_lib::detail::test_input(x, y))
    return interval<T, Policies>::empty();
  typename Policies::rounding rnd;
  typedef typename interval_lib::unprotect<interval<T, Policies> >::type I;
  T const &yb = interval_lib::user::is_neg(x) ? y.lower() : y.upper();
  T n = rnd.int_down(rnd.div_down(x, yb));
  return


was technically an independent principality of the Rajah. The difficulty was sidestepped by founding the diocese upon the island of Labuan, a Crown Colony since 1846. The bishop of Labuan could then be appointed bishop of Sarawak by the Rajah. This practice prevailed until Sarawak became a Crown Colony in 1946.

Letters Patent were issued on 6 August 1855, erecting the "Island of Labuan and its Dependencies into a Bishop's See or Diocese to be styled the Bishopric of Labuan." McDougall was nominated by the Crown as the first bishop, and was consecrated on 18 October 1855 in Calcutta. On 1 January 1856 he was appointed bishop of Sarawak.

The linked diocese of Labuan and bishopric of Sarawak increased in size as the principality grew and Anglican work in North£6.60 (compared to a paper Travelcard priced at £12.30). You can also take advantage of discounts and special offers throughout the city. Cards can be purchased and delivered to your home ahead of a trip to London.

London's city-wide bike rental service, Santander Cycles (or Boris Bikes) offers bike hire from as little as £2. There are docking stations across town and the process to rent a bike is simple. Just take your bank card to the terminal, follow the payment instructions to get a printed code and key it in to the dock to release a bike. There's a £2 bike access fee and the first 30 minutes of each journey is free. It's an additional £2 for each extra 30 minutes.

Travel by Night...MORE Bus or Night Tube


that replicate hundreds to thousands of kilobases of DNA. During this process, replication forks encounter many obstacles that block the replicative DNA polymerases and induce fork stalling. Such obstacles include DNA‐bound proteins and DNA secondary structures but also unrepaired DNA damage [29](#sct312029-bib-0029){ref-type="ref"}. Importantly, accumulation of stalled DNA replication forks defines replicative stress, which is strongly associated with chromosomal instability in cancer cells [30](#sct312029-bib-0030){ref-type="ref"}. We therefore investigated whether oxidative DNA lesions generated during ADSC expansion in the normoxic condition could alter the progression of the replisome machinery. We carried out DNA combing experiments both at the whole genome and single DNA molecule levels. ADSCs were incubated for 20 minutes in the presence of the nucleotide analogs iodo‐deoxyuridine and chloro‐deoxyuridine before DNA extraction, combing, and immunodetection (Fig. [2A](#sct312029-fig-0002){ref-type="fig"}). To estimatethe ORI. **(B):** Scatter plots of the distances traveled by right‐moving and left‐moving sister forks during the IdU pulse in ADSCs. The central areas delimited with red lines contain sister forks with less than 25% length difference. The percentages of outliers (asymmetric sister forks) are indicated (lower right of plots). Abbreviations: CldU, chloro‐deoxyuridine; IdU, iodo‐deoxyuridine; ORI, origin of replication.](SCT3-6-068-g002){#sct312029-fig-0002}

To confirm these data, we first quantified the amount of the phosphorylated form of the histone variant H2AX (γH2AX) by immunofluorescence. Indeed, H2AX is phosphorylated at stalled replication forks by the kinase ataxia telangiectasia mutated and Rad3‐related (ATR) protein, the replication pause sensor; therefore, γH2AX is widely used as a marker of DNA replication stress. As expected, we observed higher γH2AX signals in the nuclei of ADSCs cultured in the


stress, through the accumulation of stalled replication forks during the earliest stages of tumorigenesis [11](#sct312029-bib-0011){ref-type="ref"}. To obtain the relevant number of cells currently required for clinical trials, hMSCs have to be expanded ex vivo and therefore divide multiple times before transplantation. To limit the risk for tumorigenic cell transplantation, culture conditions must therefore not alter DNA replication to prevent genetic instability at both nucleotide and chromosomal levels.

In this study, we hypothesized that the elevated oxygen concentration in current GMP protocols for hMSC expansion could induce the accumulation of oxidative DNA lesions, which could, in turn, alter DNA replication. We did indeed observe an increased level of 8‐oxoG in ADSC nuclei expanded under 21% oxygen. The similar levels of 8‐oxoG at different passages suggest both the absence of anymore sensible than an expression microarray, offers greater potential to reveal differential expression patterns of DNA replication genes between cells cultured under the normoxic and hypoxic conditions. The massive downregulation of DNA replication genes detected is an important observation that concurs with the DNA replication stress observed in ADSCs expanded under the atmospheric oxygen concentration. Among the downregulated genes, we identified two genes coding for components of the replicative helicase complex, *MCM3* and *GINS3*, whose downregulation has been shown to increase DNA replication fork rate, activating the DNA damage response pathways and sensitizing cells to DNA replication inhibitors [43](#sct312029-bib-0043){ref-type="ref"}, [44](#sct312029-bib-0044){ref-type="ref"}. Moreover, *MCM* downregulation during ageing of hematopoietic stem cells activates the DNA damage response and increases DNA replication fork rate as well as fork stalling [45](#sct312029-bib-0045){ref-type="ref"}. Interestingly, we


the WBC & IBF World Welterweight Championship boxing match Saturday, Sept. 28, 2019, in Los Angeles. (AP Photo/Ringo H.W. Chiu) Ringo H.W. Chiu AP Errol Spence vs Shawn Porter LOS ANGELES, CA - SEPTEMBER 28: Erroll Spence Jr (black trunks) and Shawn Porter (white/gold trunks) exchange punches during their IBF & WBC World Welterweight Championship fight at Staples Center on September 28, 2019 in Los Angeles, California. Spence, Jr won by decision. (Photo by Jayne Kamin-Oncea/Getty Images) Jayne Kamin-Oncea Getty Images Errol Spence vs Shawn Porter LOS ANGELES, CA - SEPTEMBER 28: Erroll Spence Jr (black trunks) and Shawn Porter (white/gold trunks) exchange punches during their IBF & WBC World Welterweight Championship fight at Staples Center on September 28, 2019 in Los Angeles, California. Spence, Jr won byto the new plant in Mexico will allow
for increased production capacity in Juárez, which will help meet the fast
growing demand for all terrain and side-by-side vehicles already manufactured
in that plant. By using a specialized firm to handle the North American distribution,
BRP will gain greater flexibility to meet the projected growth of its PAC business
and will reduce capital investment while improving customer service.

"Building a global multi-market business is an ongoing
process. To remain a market leader, BRP needs to constantly challenge itself
and adapt to change," José Boisjoli, president and CEO, said. "This
is not the first time that we change things at BRP; nor will it be the last.
While we remain very much committed to our heritage and roots in Valcourt, we
must become more flexible to leverage our growth opportunities."

Over the


#ifdef _WIN32
	#pragma warning( disable: 4028 )
#endif

/*  A Bison parser, made from getdate.y
    by GNU Bison version 1.28  */

#define YYBISON 1  /* Identify Bison output.  */

#define	tAGO	257
#define	tDAY	258
#define	tDAY_UNIT	259
#define	tDAYZONE	260
#define	tDST	261
#define	tHOUR_UNIT	262
#define	tID	263
#define	tMERIDIAN	264
#define	tMINUTE_UNIT	265
#define	tMONTH	266
#define	tMONTH_UNIT	267
#define	tSEC_UNIT	268
#define	tSNUMBER	269
#define	tUNUMBER	270
#define	tYEAR_UNIT	271
#define	tZONE	272

#line 1 "getdate.y"

/*
**  Originally written by Steven M. Bellovin <smb@research.att.com> while
**  at the University of North Carolina at Chapel Hill.  Later tweaked by
**  a couple of people on Usenet.  Completely overhauled by Rich $alz
**  <rsalz@bbn.com> and Jim Berets <jberets@bbn.com> in August, 1990.
**
**  This code has been modified since it was included in curl, to make it
**  thread-safe and to make compilers complain less about it.
**
**  This code is in the public domain and has no copyright.
*/

#include "setup.h"

# ifdef HAVE_ALLOCA_H
#  include <alloca.h>
# endif

# ifdef HAVE_TIME_H
#  include <time.h>
#if (yychar == YYEMPTY && yylen == 1)				\
    { yychar = (token), yylval = (value);			\
      yychar1 = YYTRANSLATE (yychar);				\
      YYPOPSTACK;						\
      goto yybackup;						\
    }								\
  else								\
    { yyerror ("syntax error: cannot back up"); YYERROR; }	\
while (0)

#define YYTERROR	1
#define YYERRCODE	256

#ifndef YYPURE
#define YYLEX		yylex()
#endif

#ifdef YYPURE
#ifdef YYLSP_NEEDED
#ifdef YYLEX_PARAM
#define YYLEX		yylex(&yylval, &yylloc, YYLEX_PARAM)
#else
#define YYLEX		yylex(&yylval, &yylloc)
#endif
#else /* not YYLSP_NEEDED */
#ifdef YYLEX_PARAM
#define YYLEX		yylex(&yylval, YYLEX_PARAM)
#else
#define YYLEX		yylex(&yylval)
#endif
#endif /* not YYLSP_NEEDED */
#endif

/* If nonreentrant, generate the variables here */

#ifndef YYPURE

int	yychar;			/*  the lookahead symbol		*/
YYSTYPE	yylval;			/*  the semantic value of the		*/
				/*  lookahead symbol			*/

#ifdef YYLSP_NEEDED
YYLTYPE yylloc;			/*  location data for the lookahead	*/
				/*  symbol				*/
#endif

int yynerrs;			/*  number of parse errors so far


 if (yydebug)
	fprintf(stderr, "Stack size increased to %d\n", yystacksize);
#endif

      if (yyssp >= yyss + yystacksize - 1)
	YYABORT;
    }

#if YYDEBUG != 0
  if (yydebug)
    fprintf(stderr, "Entering state %d\n", yystate);
#endif

  goto yybackup;
 yybackup:

/* Do appropriate processing given the current state.  */
/* Read a lookahead token if we need one and don't already have one.  */
/* yyresume: */

  /* First try to decide what to do without reference to lookahead token.  */

  yyn = yypact[yystate];
  if (yyn == YYFLAG)
    goto yydefault;

  /* Not known => get a lookahead token if don't already have one.  */

  /* yychar is either YYEMPTY or YYEOF
    New state is final state => don't bother to shift,
       just return success.
     0, or most negative number => error.  */

  if (yyn < 0)
    {
      if (yyn == YYFLAG)
	goto yyerrlab;
      yyn = -yyn;
      goto yyreduce;
    }
  else if (yyn == 0)
    goto yyerrlab;

  if (yyn == YYFINAL)
    YYACCEPT;

  /* Shift the lookahead token.  */

#if YYDEBUG != 0
  if (yydebug)
    fprintf(stderr, "Shifting token %d (%s), ", yychar, yytname[yychar1]);
#endif

  /* Discard the token being shifted unless it is eof.  */


- 1;
      fprintf (stderr, "state stack now");
      while (ssp1 != yyssp)
	fprintf (stderr, " %d", *++ssp1);
      fprintf (stderr, "\n");
    }
#endif

  *++yyvsp = yyval;

#ifdef YYLSP_NEEDED
  yylsp++;
  if (yylen == 0)
    {
      yylsp->first_line = yylloc.first_line;
      yylsp->first_column = yylloc.first_column;
      yylsp->last_line = (yylsp-1)->last_line;
      yylsp->last_column = (yylsp-1)->last_column;
      yylsp->text = 0;
    }
  else
    {
      yylsp->last_line = (yylsp+yylen-1)->last_line;
      yylsp->last_column = (yylsp+yylen-1)->last_column;
    }
#endif

  /* Now "shift" the= '\0';
    }
  else
    abbrev = 0;

  for (tp = MonthDayTable; tp->name; tp++)
    {
      if (abbrev)
	{
	  if (strncmp (buff, tp->name, 3) == 0)
	    {
	      yylval->Number = tp->value;
	      return tp->type;
	    }
	}
      else if (strcmp (buff, tp->name) == 0)
	{
	  yylval->Number = tp->value;
	  return tp->type;
	}
    }

  for (tp = TimezoneTable; tp->name; tp++)
    if (strcmp (buff, tp->name) == 0)
      {
	yylval->Number = tp->value;
	return tp->type;
      }

  if (strcmp (buff, "dst") == 0)
    return


  {
      tm.tm_hour = ToHour (cookie.yyHour, cookie.yyMeridian);
      if (tm.tm_hour < 0)
	return -1;
      tm.tm_min = cookie.yyMinutes;
      tm.tm_sec = cookie.yySeconds;
    }
  else
    {
      tm.tm_hour = tm.tm_min = tm.tm_sec = 0;
    }
  tm.tm_hour += cookie.yyRelHour;
  tm.tm_min += cookie.yyRelMinutes;
  tm.tm_sec += cookie.yyRelSeconds;

  /* Let mktime deduce tm_isdst if we have an absolute timestamp,
     or if the relative timestamp mentions days, months, or years.  */
  if (cookie.yyHaveDate | cookie.yyHaveDay | cookie.yyHaveTime |
      cookie.yyRelDay | cookie.yyRelMonth | cookie.yyRelYear)
    tm.tm_isdst =  if (!gmt)
	return -1;
      delta = cookie.yyTimezone * 60L + difftm (&tm, gmt);
      if ((Start + delta < Start) != (delta < 0))
	return -1;		/* time_t overflow */
      Start += delta;
    }

  return Start;
}

#if	defined (TEST)

/* ARGSUSED */
int
main (int ac, char *av[])
{
  char buff[MAX_BUFF_LEN + 1];
  time_t d;

  (void) printf ("Enter date, or blank line to exit.\n\t> ");
  (void) fflush (stdout);

  buff[MAX_BUFF_LEN] = 0;
  while (fgets (buff, MAX_BUFF_LEN, stdin) && buff[0])
    {
      d = curl_getdate (buff, (time_t *) NULL);
      if (d == -1)
	(void) printf ("Bad format - couldn't convert.\n");


work with the full $SO(3)$ symmetry.\
Considering the Dirichlet problem for the differential inclusions , within a suitable class of (for instance) affine boundary conditions results in interesting behaviour: If the matrix space geometry of the set $K$ is suitable (in the sense that the lamination or rank-one convex hulls $K^{lc}$ or $K^{rc}$ are sufficiently large), it can be shown by means of convex integration [@MS] or the Baire category approach [@DaM12] that there is a very large set of solutions with very strong non-uniqueness properties. In a Baire category sense, the solution set is residual in a suitable topology (for instance in the space $W^{1,\infty}$ equipped with the $L^{\infty}$ topology). In this sense the differential inclusions are very *flexible*.

Since the inclusion problems , however have physical origins, itsimilar result is true on the level of the associated characteristic functions, c.f. Proposition \[prop:char\_reg\].

Let us comment on the result of Theorem \[thm:reg\]:

-   Theorem \[thm:reg\] improves the result in [@RZZ16] in various directions: Firstly, the regularity exponent $sp$ is *independent* of the position of the Dirichlet boundary data $M\in {\mathbb{R}}^{n\times n}$ in $\operatorname{int}(K^{lc})$. Secondly, our argument allows us to deal with both the linearised and the nonlinear problems simultaneously. Thirdly, Theorem \[thm:reg\] extends the higher regularity result for convex integration solutions from two to three dimensions, which allows us to deal with the particularly interesting model setting of the cubic-to-orthorhombic phase transformation.

-   The restriction in Theorem \[thm:reg\] to the dimensions $n=2,3$ is a consequence of the fact that we only prove suitable covering results


and thus on the initial data. However, on the sets $U_{k}^{j}$ we require *uniform* estimates, which are essential to obtain convergence in $W^{s,p}$ with $s,p$ *independent* of the initial data.

-   The constructions \[item:A3tilde\] and \[item:A3\] allow us to carry out the convex integration scheme of Müller and [Š]{}ver[á]{}k [@MS]. In addition to the requirements which are also needed for a non-quantitative convex integration scheme, the perimeter estimates in \[item:A3\] and \[item:A3tilde\] provide a first quantitative ingredient. Verifying it in our applications requires fine control of the scales involved as discussed in Section \[sec:BV\] (and Section \[sec:covering\]). In particular, in the model situations (a)-(c) from Section \[sec:intro\] we have to consider various different scenarios for the underlying geometry of the covering, which we have hence formalized inhand, we proceed to the definition of our quantitative convex integration algorithm. Here, we first provide a construction for the case when $\Omega$ is in a given class of domains $\mathcal{C}$. This is then extended in Section \[lem:Lip\] to general Lipschitz domains.

The formulation of the convex integration algorithm
---------------------------------------------------

We construct solutions to the differential inclusion at hand by abiding to the following construction rule:

\[alg:convex\_int\] Let $\Omega \subset {\mathbb{R}}^n$ be such that $\Omega \in \mathcal{C}$. Let $U_{k}^j$ and $\tilde{U}_{k}^{j}$ be as in (A2). Let $M_0 \in \operatorname{int}(K^{lc})$.

-   Data: For $k\in {\mathbb{N}}\cup\{0\}$ we consider tuples $(u_k,\hat{\Omega}_k, l_k, j_k, q_k)$, where

    -   $u_k: \Omega \rightarrow {\mathbb{R}}$ is a piecewise affine, uniformly (in $k$) bounded Lipschitz function.

    -   $\hat{\Omega}_k=\{\Omega^{k,1},\dots,\Omega^{k,i_k}\} \subset \mathcal{C}$


\chi_{k}^{(i)}\|_{L^{1}(\tilde{\Omega}_{g}\setminus \tilde{\Omega}_{g}^{\star})}
\\
& \leq  |\tilde{\Omega}_{g}\setminus \tilde{\Omega}_{g}^{\star}| \leq C_3 c_2^{\max(l_{k}(\tilde{\Omega}),m_{0})}|\tilde{\Omega}| \leq C_3 c_2^{q_{k}(\tilde{\Omega})/m}|\tilde{\Omega}|.
    \end{aligned}$$

It remains to prove the claim in , which follows from a triangle inequality. More precisely, choose $l_{0}$ sufficiently large such that $\sup\{\operatorname{dist}(M, K): M \in U_{i}^{j}\} \leq \frac{c_{1}}{3}$ for all $i
    \geq l_{0}/m$, where $c_{1}$ denotes the distance of the wells, as given in \[item:A1\]. Then $\nabla u_{k} \in U_{l_{k}}^{j_{k}}$ implies that $\operatorname{dist}(\nabla u_k, G M_{i})<
    \frac{c_{1}}{3}$ for some $i \in \{1, \dots, m\}$.

After possibly further increasing $l_{0}$, condition \[item:A4\] then yields $$\begin{aligned}
      |\nabla u_{k+1}- \nabla u_{k}| < C c_{2}^{l_{k}(\tilde{\Omega})} < \frac{c_{1}}{3}.
    \end{aligned}$$

Assume then for the sake of contradiction, that $\nabla u_{k+1}$ is closest to a differentvalue decomposition of a matrix.

\[prop:singular\_val\_decomp\] Let $A \in {\mathbb{R}}^{n \times n}$. Then there exist $V_1,V_2 \in O(n)$ and a diagonal matrix $D(A)=\operatorname{diag}(\sigma_1(A),\dots,\sigma_n(A))$ with $0\leq \sigma_1(A)\leq \dots \leq \sigma_n(A)$ such that $A=V_1DV_2$. In particular $O(n)=\{A\in {\mathbb{R}}^{n\times n}: \sigma_i(A)=1 \mbox{ for all } i \in \{1,\dots,n\}\}$. Moreover, the function ${\mathbb{R}}^{n\times n}\ni A \mapsto \sigma_n(A)$ is convex.

If there is no danger of confusion, we will in the sequel also simply write $\sigma_j$, $j\in\{1,\dots,n\}$, to denote the *singular values* of a matrix $A$.

We remark that the full decomposition $A=V_1 D V_2$ is not necessarily unique. For instance, for $Id=V_{1}^{T}Id V_{1}$ many choices of $V_{1}$ and $V_{2}$ are possible. However, the diagonal matrix $D$ is unique as we require that $$\begin{aligned}
    0\leq \sigma_1 \leq \sigma_2 \leq\dots \leq \sigma_n.
  \end{aligned}$$

Based


\tilde{U}_k^{m-1}=U_{k+1}^0, \dots, U_{k+1}^{m-1}=U_{k+2}^0, U_{k+2}^1,\dots\end{aligned}$$ forms an in-approximation for $K$, where $K=K_{h}=\tilde{K}_{h} \times \operatorname{Skew}(n)$ or $K=K_{co}=\tilde{K}_{h} \times \operatorname{Skew}(n)$. Moreover, $$\begin{aligned}
\tilde{U}^{j}_k, U_k^j \subset \operatorname{int}(K^{lc}), \ \operatorname{int}(K^{lc})= \bigcup\limits_{k,j} \tilde{U}^{j}_k.\end{aligned}$$

As the last statement is a direct consequence of the definition of the sets $U_{k}^j, \tilde{U}^k_j$, it suffices to prove the statement on the in-approximation. To this end, we first note that the symmetrized rank-one connectedness of the matrices $e^{(1)},\dots,e^{(m)}$ implies $(U_k^{j})^{lc,sym}=\operatorname{conv}(U_k^{j})$ and $(\tilde{U}_k^{j})^{lc,sym}=\operatorname{conv}(\tilde{U}_k^{j})$ by an argument similar to the one from Lemma \[lem:hulls\]. By translating in skew space and recalling Lemma \[lem:sym\_rk1\], this also yields $(U_k^{j})^{lc}=\operatorname{conv}(U_k^{j})\times \operatorname{Skew}(n)$ and $(\tilde{U}_k^{j})^{lc}=\operatorname{conv}(\tilde{U}_k^{j})\times \operatorname{Skew}(n)$. This shows condition (i) in the definition of the in-approximation. Property (ii) is a direct consequence of the definition of the sets $\tilde{U}_k^j$ and $U_k^j$.

Noting that $e^{(j)}+\operatorname{Skew}(n)$ and $e^{(i)}+\operatorname{Skew}(n)$ with $i\neq j$triangles on which $u$ is affine.

-   $\|u-Mx\|_{L^{\infty}(\Omega)} \leq C \delta \lambda (1-\lambda)|a|$.

![The diamond shaped domain of the construction of Lemma \[lem:lin\_Conti\]. Here, the triangle $P_1P_2P_3$ is highlighted.[]{data-label="fig:conti"}](figures.pdf){width="0.55\linewidth"}

By a translation in matrix space, without loss of generality, we may assume that $M=0$. By a further rotation and scaling (depending on $A-M$, $B-M$) in real space we may assume that $n=e_2$ and that $a=e_1$ (this in particular involves the passage $u \rightarrow \frac{u}{|a|}$), where we used that $a\perp n$ (by the imposed trace constraint). Hence, we have that $$\begin{aligned}
A= \begin{pmatrix}
0 & 1-\lambda \\
0 & 0
\end{pmatrix}, \ B= \begin{pmatrix}
0 & -\lambda \\
0 & 0
\end{pmatrix}, \end{aligned}$$ Without loss of generality we may further assume that $0<\lambda \leq 1-\lambda$ (else replace $A$ by $-A$ and $B$ by $-B$ and


\rightarrow {\mathbb{R}}^3$ such that

-   $u(x)=M x$ on $\partial \Omega_{\delta}$.

-   $\nabla \cdot u = 0 \mbox{ in } \Omega_{\delta}$.

-   $\operatorname{dist}(\nabla u, A\cup B)  \leq C \lambda (1-\lambda)\delta |a|$ and $$\begin{aligned}
    |\{x\in \Omega_{\delta}:\operatorname{dist}(\nabla u, A)<\operatorname{dist}(\nabla u, B)\}|&=v_A\lambda |\Omega_{\delta}|, \\
    |\{x\in \Omega:\operatorname{dist}(\nabla u, B)\geq \operatorname{dist}(\nabla u, A)\}|&=v_B(1-\lambda) |\Omega_{\delta}|,\end{aligned}$$ for some constants $v_A,v_B\in(1/2,2)$ which can be chosen as in Lemma \[lem:lin\_Conti\].

-   $\nabla u$ attains at most ten different values.

-   The domain is given as $\Omega_{\delta}= Q \operatorname{conv}(\pm e_1, \pm \delta e_2, \pm e_3)$, $Q \in SO(3)$, can be divided into 20 triangles on which $u$ is affine.

-   $\|u-Mx\|_{L^{\infty}(\Omega_{\delta})} \leq C \delta \lambda (1-\lambda)|a|$.

The proof and error bounds follow as in Lemma \[lem:3D\_O(n)\] andon $k,j$, while in the case \[item:A4\] it is required to be independent of $k,j$. Suppose further that $\Omega_g = \Omega^{\Diamond}$, which in particular yields that the conditions \[item:A3tilde\] (ii), (iii) are empty for $\Omega
= \Omega^{\Diamond}$. Denote the constants from conditions \[item:A3tilde\] (i) and \[item:A3\] by $C_{0}^{\star},C_{1}^{\star}$, if $\Omega = \Omega^{\Diamond}$, and assume that both are uniform in $j,k$.

1.  \[item:selfsimilar\_case\] If $\Omega$ is an isosceles triangle of aspect ratio $1:\delta$ oriented in in the same way as $\Omega^{\Diamond}$ (i.e. as depicted in Figure \[fig:self-similar\] top), there exists a replacement construction which satisfies \[item:A3tilde\] (ii) or \[item:A3\] with $C_{0}=C_{0}^{\star}$, $C_{1}=C_{1}^{\star}$, $C_{2}=2$ and $v_{1}=1/2$. We include the corresponding isosceles triangle in the set $\mathcal{C}^1$.

2.  \[item:box\_case\] If $\Omega = \Omega^{\Box}$ is a rectangle of aspect ratio $1: \delta \cdot


allows us to establish the good $BV$ estimates from Section \[sec:BV\] and to deduce $W^{s,p}$ regularity of our convex integration solution with $s,p$ *independent* of our initial data. If we instead accepted such a dependence, we could allow $C_{2}=C_{0}$ in \[item:A3tilde\] and $\mathcal{C}^{1}=\emptyset$ and employ a simpler covering strategy.

In this proof we proceed step by step and construct each covering/partition using the preceding ones. We remark that in all these constructions $\Omega_{g}$ is composed of copies of $\Omega^{\Diamond}$. Denoting the replacement deformation in $\Omega^{\Diamond}$ by $w$, we always obtain the new replacement construction $u:\Omega \rightarrow {\mathbb{R}}^2$ as follows: The function $u$ is always constructed to be piecewise affine, such that $u(x)=Mx+b$ in $\Omega \setminus \Omega_g$ (where $Mx+b$ with $M \in U^{k,j}$ or $\tilde{U}^{k,j}$ is the deformation that isThat is, there exists a corner $Q$ of the triangle such that $P-Q$ is orthogonal to the plane containing $T'$.

3.  A *rectangle pyramid* is the convex hull of a rectangle $R$ and a point $P$, which we require to be vertically above one of the corners.

A set $\Omega$ is then an element of the class $\mathcal{C}^0$ if it can be expressed as the union of up to $30$ of these model sets.

![The model domains for our 3D construction are ramps, triangle pyramids and rectangle pyramids.[]{data-label="fig:3D_shapes"}](figures.pdf "fig:"){width="0.2\linewidth"} ![The model domains for our 3D construction are ramps, triangle pyramids and rectangle pyramids.[]{data-label="fig:3D_shapes"}](figures.pdf "fig:"){width="0.2\linewidth"} ![The model domains for our 3D construction are ramps, triangle pyramids and rectangle pyramids.[]{data-label="fig:3D_shapes"}](figures.pdf "fig:"){width="0.2\linewidth"} ![The model domains for our 3D construction are ramps, triangle pyramids


a rectangle of half the side lengths and the height is half the height of the original rectangle-based pyramid. The remaining two parts which lie above the green and the white part of the base rectangle are ramps by construction. For every set $U_\ell$, we have $\operatorname{Per}(U_\ell)\leq \operatorname{Per}(B)$, and the assertion follows.

-   Consider now triangle-based pyramids, see the two right panels of Figure \[fig:3D\_fit\].

    We begin by discussing the case when the corner $Q$ is not above the right angle of the triangle $T'$, which is illustrated in the third panel of Figure \[fig:3D\_fit\]. Then the base triangle can be partitioned into two self-similar triangles of half the side lengths and a rectangle of half the side lengths. This partition of the basethe original triangle-based pyramid. Denoting the legs of the base triangle by $a,b$ and the height of the pyramid by $h$, we have $\operatorname{Per}(B)=\frac{1}{2}(ab+ah+bh +\sqrt{a^2+b^2} \sqrt{a^2/4+b^2/4+h^2})$ and $\operatorname{Per}(R)= \frac{1}{8} ab + \frac{1}{4}a h + \frac{1}{4} bh$. The assertion follows.

As an additional step compared to the two-dimensional setting, in three dimensions we have to verify that each level set of the construction in $\Omega^{\Diamond}$ (c.f. Lemmas \[lem:3D\_O(n)\], \[lem:lin\_Conti\_3D\]) can be partitioned into (a small number of) the above model domains.

Let $\Omega_{1}, \dots, \Omega_{N}$ denote the level sets of the three-dimensional replacement construction from Lemmas \[lem:3D\_O(n)\], \[lem:lin\_Conti\_3D\] (c.f. Figure \[fig:3D\_diamond\]). Then each set is contained in the class $\mathcal{C}^0$ given in Definition \[defi:3D\_shapes\].

![The 3D diamond and the 2D diamond. The three-dimensional diamond is obtained by embedding the two-dimensional construction which


two home and two away.

"We can take care of our business. We can't take care of what they do," said Robinson. "Today they slipped up a little bit and we took care of business, but there's still lots of points to play for."

Real Salt Lake (13-7-10) needed just a draw to clinch a seventh straight playoff berth, but will instead have to wait at least one more week.

Moments before giving his team the 2-1 advantage, Morales sizzled a shot at Attinella that the 'keeper could only push over the bar, before Real's Sebastian Jaime moved in on Ousted but couldn't get a shot on target after being pressured by a hard-charging Beitashour.

Failed solo effort

After Vancouver took the lead, Manneh had a chance to ice it but decided againstmechanisms underlying ripple oscillations in the model, and the role of pyramidal cells in the overall ripple structure. We conclude showing that selective input from CA3 can induce sequential reactivation of CA1 pyramidal cells during ripples in our model.

Results {#sec002}
=======

Data description: Ripples duration in CA1 has narrow variance {#sec003}
-------------------------------------------------------------

Data shows that ripples are local events \[[@pcbi.1004880.ref022]\], and that a given CA1 pyramidal cell rarely spikes more than once per ripple oscillation \[[@pcbi.1004880.ref010], [@pcbi.1004880.ref023], [@pcbi.1004880.ref024]\]. Many pyramidal cells are not recruited by ripples recorded across different sessions, while some are recruited by almost all events. On average 10% of pyramidal cells are active in any given ripple, and their spikes are locked to the trough of each the oscillations within a ripple event \[[@pcbi.1004880.ref025], [@pcbi.1004880.ref026]\]. On the other hand,


limited to within about 200% of the baseline value. Also, in the condition of α = 0, when the network is disconnected, one can still see the noise-induced de-synchronization; when the network has active and fast (small τ) synaptic connections the de-synchronization is delayed ([Fig 5C](#pcbi.1004880.g005){ref-type="fig"}). The increase of inhibition (through longer decay times or stronger conductances) resulted in the reduction of both the transient oscillation frequency ([Fig 5D](#pcbi.1004880.g005){ref-type="fig"}) and its peak count ([Fig 5E](#pcbi.1004880.g005){ref-type="fig"}). This is an important observation and it highlights the point that oscillations in this system are not a rhythm in the traditional sense of the word: they are not an oscillation that would persist in time as long as there are no changes to the CA1 model or the input, but rather aNote that synchrony is strongly affected, and the transient is composed by a drastically reduced number of cycles (b). (c, d) Effect of noise and strength of inhibition on transient properties. (c) Histograms of firing probabilities, for changing synaptic strength (scaled by α) and noise standard deviation (scaled by σ). The time axes is binned in 1ms bins. (d) Top panel: number of cycles composing the transient event. Bottom panel: network frequency.](pcbi.1004880.g006){#pcbi.1004880.g006}

We next investigated the role of noise in setting the duration and frequency of oscillatory transients in the inhibitory network. We progressively reduced the noise coefficient using a scaling factor σ. [Fig 6C](#pcbi.1004880.g006){ref-type="fig"} shows the network behavior in the case of reduced noise amplitude, where spikes were far more synchronized around the network peaks compared to the


oscillation is triggered only at high frequencies above the gamma (30--90 Hz) range. As it is known that the interaction between pyramidal cells and basket cells in hippocampal CA1 region underlies gamma (30--90 Hz) oscillations \[[@pcbi.1004880.ref047], [@pcbi.1004880.ref048]\], the above findings suggests the mechanism recruiting ripple oscillations can co-exist with, and be independent from, other slower rhythms that arise in the same region.

It is also important to note that ripple characteristics (frequency, duration) in the full model receiving input from CA3 that was scaled in size saturated at around 80% of the baseline input and remained stable above this value ([S4 Fig](#pcbi.1004880.s004){ref-type="supplementary-material"}). Thus, ripple properties predicted by our model to match experimental data are observed in the broad range of CA3 mediated input amplitudes, i.e., structurally stable. Our resultsms \[[@pcbi.1004880.ref021]\]. Immediately after the initial high frequency response, the LFP amplitude in the high-frequency band decreased and the activity slowed down to about 80 Hz. In agreement with these data, in our model, we first achieved a high frequency firing for about 25 ms, but the pyramidal cell population was not able to sustain firing much longer ([Fig 7E](#pcbi.1004880.g007){ref-type="fig"}).

A variable controlling the ability of pyramidal cells to sustain firing is the strength of spike-frequency adaptation, which in the model equations is controlled by the size of the jump (b) imposed on the slow refractory variable (w) after each spike (see [Materials and Methods](#sec012){ref-type="sec"}). Since change in adaptation can be biologically achieved by a variety of neuromodulatory phenomena, and the less adaptive the cell is, the longer it


in CA3, consistent with the fact that CA3 to CA1 connectivity is crucial for memory consolidation \[[@pcbi.1004880.ref054]\].

A common hypothesis is that synaptic connections between CA1 pyramidal cells and intrinsic cell properties regulate the order of spiking in a CA1 sequence \[[@pcbi.1004880.ref053]\]. In our study we tested this hypothesis first. Since in CA1 very few pyramid-to-pyramid synapses are found, we only had to check the effect of DC input. We found that preferential DC levels, even much stronger than average, were not enough to guarantee a robust repetition of the correct order of firing in our target cells. We then tested the potential role of the incoming CA3 input. Given the projection onto CA1 pyramidal cells are plastic, and that CA3 is the most typical set in which Hebbianis composed of different parts. The *I*~*DC*~ term variability produces variability in the excitability level of each cell, therefore introducing a first level of heterogeneity in the network. The noise term *βη*~*t*~ represents the *in vivo* state of the voltage in each cell, which is likely receiving a much higher barrage of synaptic inputs than the one provided by the network spiking activity. *η*~*t*~ is an Ornstein Uhlenbeck (OU) process, which can be thought of as a filtered white noise process. This kind of noise does not introduce slow frequency forcing, which could alter the network behavior, or too high frequency voltage fluctuations, which are known to not be present \[[@pcbi.1004880.ref075]\]. This kind of noise is also used in dynamic-clamp experiments to mimic *in vivo* state in hippocampal


as a dynamical system.

The incoming current input *I*~*inp*~*(t)* is bell-shaped, gradually rising and falling, between t~on~ and t~off~. Incoming input from CA3 reaches a maximum value *I*~*max*~ different across populations, chosen to obtain a fraction of pyramidal cell spiking during ripples consistent with experimental data \[[@pcbi.1004880.ref024], [@pcbi.1004880.ref043]\] and a firing frequency for interneurons about 120 Hz \[[@pcbi.1004880.ref023]\]. When a net current is used to represent the sum of a barrage of incoming post-synaptic currents, such current has to take into account the scaling that cell properties will operate on the post-synaptic currents. Since cell membranes have capacitive and resistive properties, there will be a time scaling by a time constant which is the cell time constant. Since we add the current input to the right-hand side of thefound when the filtered LFP (50--350 Hz) exceeded a threshold of 5 standard deviations of the mean computed in one SWR-free second of activity.

Analysis of inhibitory network model {#sec017}
------------------------------------

To estimate the duration of synchrony in a purely inhibitory network receiving a current step input of size k at time t = 1s ([Fig 5](#pcbi.1004880.g005){ref-type="fig"}), we considered histograms of spike probability constructed averaging 200 trials. The asymptotic value (lim) of the histogram was the average firing probability between 1.5 s and 2 s. The heights of peaks in the histograms were decreasing in time. The size of the first peak (p1) defined a threshold 0.2\*(p1-lim). The first peak that was far from lim less than threshold marked the end of the transient.

Supporting Information {#sec018}
======================

###### Details of ripple property estimation.

The


OF MERCHANTABILITY,
 * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
 * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
 * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
 * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
 * THE SOFTWARE.
 */
export var cssClasses = {
    // Ripple is a special case where the "root" component is really a "mixin" of sorts,
    // given that it's an 'upgrade' to an existing component. That being said it is the root
    // CSS class that all other CSS classes derive from.
    BG_FOCUSED: 'mdc-ripple-upgraded--background-focused',
    FG_ACTIVATION: 'mdc-ripple-upgraded--foreground-activation',
 the city's central business district. Hong Kong's travel and tourism sector has been particularly hard hit, while luxury brands such as Prada and Louis Vuitton have also closed stores in the city. The unrest has seen Hong Kong plunge into recession, with business confidence falling to its lowest level in a decade.

The San Francisco outpost of the government's Economic & Trade Office (ETO) — which promotes the city's economic and trade interests around the world — is focusing its PR search on key audiences in the US Western region, including corporate America, the financial and investment community, and the media.

Unlike the government's earlier, fruitless, search for PR support in Hong Kong, the ETO brief makes no overt mention of the protest movement that has become synonymous with Hong


address the city's mounting issues helped to scupper a previous PR agency search, when eight global firms turned down the opportunity to bid for a wide-ranging strategic communications brief.

Mirroring those concerns, at least one global PR firm contacted by the Holmes Report has chosen to pass on the ETO brief, citing questions over how the assignment would reflect on its Hong Kong operations, given the political nature of the work.

Neither the Hong Kong ETO in San Francisco nor Singer Associates had responded to request for comment as this story went live.

Despite the business downturn, the successful $13bn secondary listing of Alibaba in Hong Kong last year has seen the city's stock exchange turn its attention towards China's booming high-tech sector, and — more broadly — towards mainland investors,would stand guardian over, but he never got to know any of them on a personal level.

For this reason, Sapheda and Kala were his only companions. He would talk to them like best friends would, seeing them as family more than anything. To this day, he still treats most other people hostile, and sees these two beings as his only friends. However, due to the lack of up-bringing, he had always had a negative onlooking for life. Despite his depression and loneliness seeping into his brain ever so more, he became rather anxious when he thought about his future. If anyone gave him a problem in Hell, he would crush them into dust and move on. He went into deep slumber for a long time, a form of


1. Field of the Invention
The present invention relates to bowling by the blind or visually impaired. More specifically, the invention is a system used to aid blind or visually impaired bowlers to approach the foul line without going beyond it, and deliver the ball in a direction so as to knock over the most pins.
2. Description of the Related Art
Apparatus for teaching and assisting bowlers both blind and sighted have been provided in the past. These device generally assist bowlers in directing the ball down the lane. U.S. Pat. No. 2,336,997 issued Dec. 14, 1943 to Paul N. Mobley teaches a bowling instruction apparatus. The apparatus includes a sighting signal that is transversely adjustable across a bowling lane. The sighting signal is mounted above an intermediate portion ofYour style show is the hit of local television, but you have your suspicions that your rocketing career is buoyed by brilliant accessories like these cameo earrings. Crafted with antique-like charm, these oval earrings flaunt a bouquet of pink roses at their center and a frame of gold at the edges. For today’s broadcast, you add these sweet posts to a striped linen dress, pull on a canary-colored headband, and get ready for your close up!


Whigs and supported the naturalization of the Palatines in 1709. He voted for the impeachment of Dr Sacheverell in 1710. |At the 1710 British general election he was returned unopposed for Reading. He again acted as a teller and was an active opponent of the ministry's trade policy, voting against the French commerce bill in 1713. He was defeated at the 1713 British general election, but became a Gentleman of the Privy Chamber in 1714.

Buckingham was returned for Reading at a by-election on 6 June 1716. He was appointed a Commissioner for victualling the Navy in 1717 and was returned without opposition at the ensuing by-election. He voted with the Administration on the repeal of the Occasional Conformity and Schism Acts and on the peerage bill in 1719.

Onthe highest karyotype variation and were also the most specious families in order. [Figure 1](#f1){ref-type="fig"} shows the magnitude of this variation. In general, for Brazilian rodents, the diploid number ranged from 2n = 10 for *Akodon* sp. from Mato Grosso ([@B10]; [@B11]) to 2n = 118 for *Dactylomys boliviensis* ([@B3]). Among Sigmodontinae, we observed a pattern showing that the Akodontini tribe has a smaller average 2n compared to Oryzomyini ([Figure 1A](#f1){ref-type="fig"}). A segregation pattern was also observed for terrestrial and semi-fossorial Echimyidae; which showed a 2n smaller than that for arboreal Echimyidae ([Figure 1B](#f1){ref-type="fig"}).

![Diploid (2n) and Fundamental numbers (FN) variation between (A) species belonging to the Subfamily Sigmodontinae Wagner, 1843 and (B) species of the family Echimyidae.](1415-4757-GMB-1678-4685-GMB-2017-0131-gf01){#f1}

The shape of the sex chromosomes also varied. We observed predominant forms


of both X and Y chromosomes (the form that appears most often). In Sigmodontinae tribes, the variation in sexual pairs was curious, particularly for the X chromosome ([Figure 2](#f2){ref-type="fig"}). In Oryzomyini and Thomazomyini, in most cases, the X chromosome is large submetacentric ([Figure 2A,B](#f2){ref-type="fig"}), while in Akodontini the predominant form is acrocentric medium ([Figure 2C](#f2){ref-type="fig"}). On the other hand, the Y chromosome is predominantly small acrocentric in Oryzomyini, Thomasomyini, Akodontini, and Phyllotini ([Figure 3A-D](#f3){ref-type="fig"}). In Phyllotini, the X chromosome is highly variable ([Figure 2D](#f2){ref-type="fig"}). Among Echimyidae, the representatives of an arboricolan lifestyle mostly have a large submetacentric X chromosome, whereas those from terrestrial habitats have a medium acrocentric X chromosome ([Figure 2E](#f2){ref-type="fig"},[F](#f2){ref-type="fig"}). Among Echimyidae, the Y chromosome is small acrocentric, regardless of habitat ([Figure 3E,F](#f3){ref-type="fig"}).

![The most usual Xemiliae, Marmosops impavidus, M. incanus, M. noctivagus* and *M. paulensis*; and small submetacentric: *Cryptonanus guahybae, Gracilianus microtarsus, Marmosops neblina, M. parvidens, Thylamys karimii, T. velutinus* and *Caluromys lanatus*) ([Figure 4A](#f4){ref-type="fig"}). The others showed different forms such as small acrocentric in *Metachirus nudicaudatus* and *Cryptonanus agricolai*, and acrocentric or small submetacentric in *Caluromys philander*. The Y chromosome of Brazilian marsupial was mostly small acrocentric ([Figure 4D](#f4){ref-type="fig"}). *Marmosops noctiv*agus has a small metacentric Y chromosome. For *Cryptonanus agricolai, Marmosops neblina*, and *Caluromys philander*, the form of the Y chromosome remains unknown. In relation to the species that showed 2n = 18, the most common form of sexual chromosomes was small acrocentric for both X and Y. Furthermore, they both showed a frequency of 62.50% ([Figure 4B](#f4){ref-type="fig"}). Species that showed a


a constant value called MENU_TURN_SCREEN_BLUE. This would store an arbitrary number which you can later use as an id. For example (keeping in mind Menu.FIRST = 1:
private static final int MENU_TURN_SCREEN_BLUE = Menu.FIRST + 60;

or
private static final int MENU_TURN_SCREEN_BLUE = 69084;

Are both valid. Now, when you add a new item to a menu with the add() method, you can use this value:
menu.add(0, TURN_SCREEN_BLUE, 0, "Press To Turn Screen Blue");

You could of course just write the number in directly, but constant are helpful (amongst other reasons) for avoiding bugs in your code that arise from accidentally typing in the wrong  number.
Keep in mind though that there are other ways to generate unique id's - see this question for details.

Microchips have become prevalent in virtually all types of industries, and the demand for microchips has skyrocketed over the last ten years. This has placed pressure on the industry to make more and better chips as the need for microchips continues to rise. A chip connects to a motherboard or other device via a plurality of pins or terminals, which allows the board to communicate with the chip's logic or memory. An example of such a chip may be a memory card or processor for a computer, each of which may be insertable into a particular slot or socket that makes one or more electrical connections with the chip.
Part of the manufacturing process of the chips is the post-production testing of the quality and performance of the chip.


}

    this.getName = function()
    {
        return this.name;
    }

    this.getGender = function()
    {
        return this.gender;
    }
}

Job.js
function Job(title)
{
    this.title = title;
    this.description;

    this.setDescription = function(description)
    {
        this.description = description;
    }
}

main.js
function  main()
{
    var employee = new Person("Richard", 23, male);
    document.getElementById("mainBody").innerHTML = employee.getName();
}

index.html
<!DOCTYPE HTML>

    <title>javascript test</title>

any help or advice would be greatly appreciated.
Many thanks
EDIT:
Many thanksmarsh, with the Little River running through it. Today that area is office parks, industrial and high-tech firms, and the Alewife Reservation. The Route 2 of today (dotted pencil line) crosses what was a "Cart path shaded by willows" and the "Site of former Heronry of Night Herons, also of Robin Roost."

People have been engineering this watershed for many years, by digging ditches to drain fields, re-channeling streams, damming Alewife Brook, and so on, for different reasons at different times.

Above is a detail of a 1901 map, with the T stop indicated in pencil. If you zoom in on the full-size image just above the "Ave." in "Concord Ave." (street near bottom of map), you'll see a "packing house," which is the slaughterhouse mentioned below.

As population and industrialization


to those of a century ago, and still evolving. I hope that our notion of public health, our notion of our own self-interest, will once again come to include the health of the Little River and the local marshes, Wellington Brook, Blair Pond, Perch Pond and all the rest of the ponds and waterways named and unnamed. I don't think this is a sentimental idea. It certainly was not in 1900, when the public demanded action before the Board of Health.

People get used to everything, and the human time horizon is very close in. We tend to think that the way things are today "just is." But the way things are today is a history of decisions, some good and some rotten, the outcome of a chronicle ofaccounted for 9.7 % of all EU 27 exports of food, beverage and tobacco products, which was higher than the Russian share of all EU-27 industrial exports (7.2 %). The share ... The United States, Russia, Japan and Switzerland were key export markets for EU ... China Russian Federation United States Rest of the world Japan Switzerland Switzerland European business — Facts and figures

Graph 27: EU-10 and EU-15: Export market shares in value terms, 1991-2005 EU-15 share of the EU-10 market (lhs) EU-10 share of the EU-15 market (rhs) Note: Excluding intra-EU-10 and intra-EU-15 trade. Source: Commission services calculations ... As shown in Graph 26, export growth in the EU-10 has been more dynamic than in the EU-15 over the past 10 years. The strong export performance of


is that individual racers can soup up themselves with whatever cybernetic enhancements they can manage, making for a fast and deadly sport.

If you haven’t seen Alita, you’ll be pleased to know the Motorball sequences are easily some of the best in the film to experience in 3D, and watching them will make you wonder when Cameron and director Robert Rodriguez are going to get into the virtual theme park game. Although it shouldn’t go without mentioning that the first time we see Motorball played, it’s not in a massive stadium. It’s a pickup game between neighborhood kids that feels like what The Mighty Ducks would’ve looked like had Cameron been behind the camera.

CBR spoke with Alita: Battle Angel stars Keean Johnson (Hugo), Jorge Lendeborg Jr. (Tanji) and LanaMaximum Packet Size <1-1024>
//             <o6> Maximum NAK Rate <0-255>
//           </e>
//         </h>
//       </h>
//       <h> Mass Storage Device Settings
//         <i> Device specific settings
//         <s0.126> MSC Interface String
//         <h> Inquiry Data
//           <s1.8>  Vendor Identification
//           <s2.16> Product Identification
//


        <o5.0..10> Maximum Endpoint Packet Size (in bytes) <0-1024>
//             <o5.11..12> Additional transactions per microframe <0=> None <1=> 1 additional <2=> 2 additional
//             <o6.0..10> Endpoint polling Interval (in ms) <1=>      1 <2=>      2 <3=>      4 <4=>      8
//                                           (USBD_MSC_EP_BULKOUT == USBD_CDC_ACM_EP_BULKIN)  || \
       (USBD_MSC_EP_BULKOUT == USBD_CDC_ACM_EP_BULKOUT))
#error "Mass Storage Device and Communication Device Interface can not use same Endpoints!"
#endif
#endif
#endif

#if    (USBD_ADC_ENABLE)
#if    (USBD_CDC_ACM_ENABLE)
#if   ((USBD_ADC_EP_ISOOUT  == USBD_CDC_ACM_EP_INTIN)   || \
       (USBD_ADC_EP_ISOOUT  == USBD_CDC_ACM_EP_BULKIN)  || \
       (USBD_ADC_EP_ISOOUT  == USBD_CDC_ACM_EP_BULKOUT))
#error "Audio Device and Communication Device Interface can not use same Endpoints!"
#endif
#endif
#endif
#define USBD_ADC_CIF_NUM           (0)
#define USBD_ADC_SIF1_NUM          (1)
#define USBD_ADC_SIF2_NUM          (2)

#define USBD_ADC_CIF_STR_NUM       (3+USBD_STRDESC_SER_ENABLE+0)
#define USBD_ADC_SIF1_STR_NUM


 (0)
#endif
#if    (USBD_ADC_ENABLE)
#if    (USBD_ADC_HS_ENABLE)
#define USBD_ADC_MAX_PACKET       ((USBD_ADC_HS_WMAXPACKETSIZE > USBD_ADC_WMAXPACKETSIZE) ? USBD_ADC_HS_WMAXPACKETSIZE : USBD_ADC_WMAXPACKETSIZE)
#else
#define USBD_ADC_MAX_PACKET        (USBD_ADC_WMAXPACKETSIZE)
#endif
#else
#define USBD_ADC_MAX_PACKET        (0)
#endif
#if    (USBD_CDC_ACM_ENABLE)
#if    (USBD_CDC_ACM_HS_ENABLE)
#define USBD_CDC_ACM_MAX_PACKET   ((USBD_CDC_ACM_HS_WMAXPACKETSIZE > USBD_CDC_ACM_WMAXPACKETSIZE) ? USBD_CDC_ACM_HS_WMAXPACKETSIZE : USBD_CDC_ACM_WMAXPACKETSIZE)
#else
#define USBD_CDC_ACM_MAX_PACKET    (USBD_CDC_ACM_WMAXPACKETSIZE)
#endif
#if    (USBD_CDC_ACM_HS_ENABLE1)
#define USBD_CDC_ACM_MAX_PACKET1  ((USBD_CDC_ACM_HS_WMAXPACKETSIZE1 > USBD_CDC_ACM_WMAXPACKETSIZE1) ? USBD_CDC_ACM_HS_WMAXPACKETSIZE1 : USBD_CDC_ACM_WMAXPACKETSIZE1)
#else
#define USBD_CDC_ACM_MAX_PACKET1   (USBD_CDC_ACM_WMAXPACKETSIZE1)
#endif
#else
#define USBD_CDC_ACM_MAX_PACKET    (0)
#define USBD_CDC_ACM_MAX_PACKET1   (0)
#endif

#if    (USBD_BULK_ENABLE)
#if    (USBD_BULK_HS_ENABLE)
#define USBD_BULK_MAX_PACKET       ((USBD_BULK_HS_WMAXPACKETSIZE > USBD_BULK_WMAXPACKETSIZE) ? USBD_BULK_HS_WMAXPACKETSIZE : USBD_BULK_WMAXPACKETSIZE)
#else
#define USBD_BULK_MAX_PACKET        (USBD_BULK_WMAXPACKETSIZE)
#endif
#else
#define USBD_BULK_MAX_PACKET     Description

Now available for the first time in over two years – EXTREMELY LIMITED SUPPLY! If we do not have your preferred size or condition, please sign up for email updates when and if we have more inventory in coming years.

This is a used Canada Goose down parka, made exclusively for the official United States Antarctic Program and affectionately named “Big Red” by Antarctic researchers. This parka is an Antarctic Program exclusive version of the popular Canada Goose 4660M “Expedition Parka”, which sells new for $1,095.00 USD.

“Big Red” is issued by the US Antarctic Program to all scientists and staff serving at the two largest American research stations in Antarctica, McMurdo Base and South Pole Station. The parkas for sale here have been sold as surplus by the Antarctic


var convert = require('./convert'),
    func = convert('isObject', require('../isObject'), require('./_falseOptions'));

func.placeholder = require('./placeholder');
module.exports = func;
         }
        ]
    }
});

module.exports = Client = mongoose.model('client', ClientSchema);

And here is the method posting the form results:
router.post('/:id', auth, (req, res) => {
    Client.update(
        { clientID: req.params.id },
        {
            $push: {
                formResults: {
                    $each: [


(1/53) grade D2 PVR; 30.2% (16/53) of the patients had no classifying register. Follow-up varied from 256 days to 4,421 days (mean 1,262 + −944 days). The median time of silicone oil extraction was 196 days after its placement. The mean intraocular pressure was 15.6 + −7.4 before and 14.8 + −6.2 after silicone oil removal. Phacoemulsification with IOL implantation was combined with silicone oil removal in 14 eyes (26.4%) (Figure [2](#Fig2){ref-type="fig"}A).Figure 2**Anatomical results after silicone oil removal and comparison between single and combined procedure with phacoemulsification.**

Forty-eight (90.5%) patients had attached retina at the last follow-up visit (Figure [2](#Fig2){ref-type="fig"}B). The mean period of silicone oil duration in the vitreous cavity was 228 + −152 and 275 + −265 days in cases with and without redetachment, respectively. There was no association between duration of intraocular silicone oil and risk for retinal redetachment (p = 0.6997). The rate ofretinal redetachment in patients submitted to phacoemulsification combined with silicone oil extraction was 21.4% (Figure [2](#Fig2){ref-type="fig"}C), which represented 60% of all the redetachment cases (Figure [2](#Fig2){ref-type="fig"}D), but not statiscally significant (p = 0.0735).

Twenty-three patients (43.4%) showed BCVA improvement, eleven patients (20.8%) were stabilized and 19 patients (35.8%) had a BVCA worsening. Mean preoperative and postoperative values of BCVA were 0.95 logMAR (Snellen = 20/160) and 1.01 logMAR (Snellen = 20/200) respectively (Figure [3](#Fig3){ref-type="fig"}). Severe visual worsening was observed in 15 patients (28.3%), of whom five had unexplained optic disc atrophy.Figure 3**Comparison of BCVA between preoperative examination and last follow-up assessment.**

Combined phacoemulsification with intraocular lens implant and removal of silicone oil did not influence the final visual acuity when compared to the isolated extraction of silicone oil (p = 0.426). In addition, BCVA worsening could not be directly associated with


best." "I guess." "I'm worried about Lulu." "I wonder if she'll be okay." "then you can just go to her." "But this time I'm concerned about you." "but you're alone." "right?" "I'm just going to follow until then." "I'll protect you." "It's up to you." "Do as you wish." "And I will." "after all." "are all in position." "The Miss and Zest are in position as well." "All preparations for attack are complete." "Only thing that's left is to wait for the signal." "Seems like you're having fun." "I am." "It's the moment I change this planet's history with these hands." "it's obvious I'd be overflowing with joy." "Uno?" "We'll show something special to our sponsor." "and development." "let us begin!" "Yes'sir." "Mission start!" "limiter release." "An energywho can get passed them." "There's no real need to get all the way inside if we just surround you and keep you powerless." "So we've been locked in?" "There's a highly dense AMF." "Magic can't be concentrated." "Transmissions won't get through either." "We've been had." "this is your first battle." "There's no need for worry." "I wasn't born late for no reason." "IS activate." "SLAUGHTER ARMS" "RIDE IMPULSE" "ACTION" "but rather a paralyzing one." "I'm sending the defense data to you now." "The jamming's strong." "Long Arch!" "but the situation inside is unknown." "we'll head inside." "We have to rescue Nanoha-san and everyone else." "There are aerial units heading toward HQ." "They're fast!" "Ranks are estimated to be S+." "Rein!" "Right!" "Rein and I will head up."


pretty average results (I won’t name names, but there’s some dross out there). Where Tame Impala stand out in comparison with their psychedelically-inclined peers is that Kevin Parker’s lyrics are very direct and the emotions behind his vocal delivery are clear. His songs are free to wander off in any direction he wants because the listener has a lifeline to hold on to. Listening to music touted as ‘psychedelic’ can often feel like listening to a description of someone else’s dream - utterly tedious, regardless of what is going on in the other person’s mind. Kevin Parker has an uncanny way of putting you inside his head, wherever his music takes you. Brian Wilson, when he was writing his own lyrics, had a similar emotional directness that anchored(intimal proliferation) were first seen at 7 months, lying beneath a new internal elastic lamina. They showed a reduction in myofilament concentration in the more fibrotic lesions. In all cases, endothelial cells were abnormally thick (P less than 0.001) and elongated. Cytoskeletal remodelling was indicated by an increase in micro- and intermediate filament volume density (P less than 0.05 for both). The severity of endothelial damage was related to vessel size and position in the arterial pathway. These findings indicate that pulmonary vascular disease begins at or soon after birth with abnormal pulmonary vascular remodelling which leads to obliterative pulmonary vascular disease.


});
            }
            else {
                mActivity.requestPermissions(permissionsList.toArray(new String[permissionsList.size()]),
                        REQUEST_CODE_ASK_MULTIPLE_PERMISSIONS);
            }
            ret = false;
        }

        return ret;
    }

    private void showMessageOKCancel(String message, DialogInterface.OnClickListener okListener) {
    in the volume "Semiconductor Memory Design and Application" by G. Luecke et al., published by McGraw-Hill Book Company as a part of the Texas Instruments Electronics Series.
The prior art has also disclosed the use of a phenomenon known as "charge pumping" in a random access memory cell. One such example has been disclosed in "Semiconductor Memory Design and Application", supra, at page 132, Section 5.6.2, pages 132-134, in which the charge pump phenomenon was employed in a crosscoupled RAM cell utilizing semiconductor load devices. A charge pump supply provided a constant current supply which was deemed to be an ideal load device, and which could be achieved with minimum geometry while still retaining the high load resistance.
In a paper delivered to the 1976 IEEE International Solid State Circuits


because silicon is a semiconductor. In this context, a technique is proposed in which a switch circuit for radio frequency signals is formed on an silicon on insulator (SOI) substrate.
In a radio frequency switch based on MOSFET, for example, to achieve radio frequency characteristics (such as insertion loss and ON distortion/OFF distortion) required for cell phones, it is necessary to generate an appropriate gate potential inside the radio frequency switch.
However, such a voltage generator is limited in current supply capacity because of restriction on the layout area. Hence, if a cross current over the current supply capacity occurs in the load of the voltage generator at power-on, there is a possibility of an incorrect operation in which the voltage generator fails to reach the desired potential.don’t know about the things we think we understand. Nor is this a problem or a momentary lack of closure. Science is altogether dynamic and wonderfully incomplete.

Looking just at my field, evolutionary biology, the unknowns are immense: How widespread are nonadaptive traits? To what extent does evolution proceed by very small, gradual steps versus larger, quantum jumps? Why does sexuality occur at all, since it is fully one-half as efficient in projecting genes into the future compared with its asexual alternative? What is the purpose of all that “junk DNA”? Did human beings evolve from a single lineage, or many times, independently? Why does homosexuality persist? Why do women — unique among mammals — conceal their ovulation, possess conspicuous nonlactating breasts and experience orgasm, as well as menopause?


promising.

There is a difference between science as a body of knowledge and science as the pursuit of the unknown. Ideally, there would be no tension between the two because it’s only by pursuing the unknown that we obtain knowledge. And yet, these two aspects of science coexist uneasily. This wasn’t always the case.

Between 1751 and 1765, the Encyclopédie was published in France. It endeavored to summarize all human knowledge in its 18,000 pages of text, 75,000 different entries and 20 million words. Its primary editor, Denis Diderot, was one of the heroes of the Enlightenment, and indeed, the Encyclopédie represents a culmination of Enlightenment thought, which valued reason, science and progress — what we know — above all else.

It is paradoxical testimony to how much we have learnedThe scapular island flap: a new application for breast reconstruction.
The scapular fasciocutaneous island flap was explored as a surgical option to supply autologous skin or volume replacement for breast reconstruction. Its use in two clinical cases illustrates its versatility for the salvage of complications of prior reconstruction. It may serve as a reliable alternative source of well-vascularized autologous tissue if other first-line choices are not available.


has changed, as have the challenges facing the country.

Ambiguities of protest

Until 24th September 2011, when Putin announced his planned return to the presidency, with Medvedev swapping roles to become prime minister, sticking with the status quo paradoxically contained the promise of potentially radical intra-systemic change and evolution. It was this potential that was apparently stifled, if not killed, by the change. Not only did this cynical and contemptuous ‘castling’ move evoke popular disgust but, following the flawed parliamentary elections on 4th December, widespread popular protest indicated that the mystical bond (enhanced by rather less than mystical media manipulation) that had united Putin and the people was fraying. This current of popular protest will undoubtedly ebb and flow, but will not disappear, and it signals that the regime hasmuch of the protest against the Putinite system is itself Putinite in character – depoliticised, mute and gestural – indicating the deep social roots of the present system. Vladimir Pastukhov has recently argued that Putinism as a historical phenomenon is much larger than Putin the man, and reflects the traditional estrangement in Russia between the state and society. From this perspective, getting rid of Putin would hardly change the structures of power and the fundamental relationships between social actors.

‘…contrary to much hysterical commentary in the West, the regime is nowhere near collapse and the country is not badly governed’

This is a powerful argument, but it has two possible political corollaries. The first is the encouragement of political passivity, since getting rid of one lot of scoundrels runs the


certain cases family relationships. The key elite groups were identified as the ‘force’ (the ‘siloviki’), ‘political’, ‘technical’ and ‘entrepreneurial’ factions.

Putin crowns the system, balancing interests and preventing any single one becoming predominant. To do so, as I argued above, would threaten his own independence, rendering him potentially hostage to a single faction; but at the same time, he cannot be seen as a mortal threat to any of the groups, since that would render him a liability for them. In other words, he has to have enough power to prevent factional conflict spiralling out of control and becoming a war of all against all; but at the same time this power has to be disguised and shared, to allow key constituencies to retain a stake in the system.

Putin’ssettlement of the Putin years. Part of the reason for declining elite coherence was of course the fact that Medvedev clearly entertained hopes of a second run at the presidency. He had successfully gained a political identity of his own, aligning himself with gradual political liberalisation, partnership with the Western powers, and less statist economic policies. What he had failed to do was gain political autonomy. Faction management remained Putin’s responsibility. The Medvedev presidency and its liberalising acolytes represented no more than just another faction, and not the most powerful one at that. In other words, the attempt to provide an evolutionary option from within the Putin system was defeated by the character of the system itself. A faction could not overcome the logic of factionalism. In September


Roaming into danger (Image: Jeff Foott/Discovery Channel Images/Getty)

THE slaughter of hundreds of buffalo straying from Yellowstone National Park has been given the legal green light in Montana.

The wild buffalo, which are classed as “near-threatened”, can wander beyond park boundaries during the winter in search of food. Ranchers worry that they will pass the disease brucellosis to cattle in Montana, which is currently designated “brucellosis-free”. The infection does not usually cause symptoms in buffalo, but can trigger abortions in cows.

Over the past few weeks, around 525 straying buffalo have been corralled along the park’s borders. Almost half have tested positive for brucellosis and are the first up for slaughter.

The Buffalo Field Campaign maintains that the risk of disease transmission is low. The group says “relatively few” susceptible cows grazewe cannot agree he was denied due process.   See Greenholtz, 442 U.S. at 15-16, 99 S.Ct. at 2107-08 ("To require the parole authority to provide a summary of the evidence would tend to convert the process into an adversary proceeding and to equate the Board's parole-release determination with a guilt determination.").

16
Bagley's final constitutional contention is that the parole conditions are cruel and unusual punishment in violation of the eighth amendment.  In support of this argument, Bagley cites Dear Wing Jung v. United States, 312 F.2d 73 (9th Cir.1962).  In Dear Wing Jung, the defendant, an alien, was given a suspended sentence on condition that he leave the country.  This conditional departure would have amounted to permanent banishment from the United States, since the


import * as jwt from "jsonwebtoken";
import * as _ from "lodash";
import getMysqlPool from "../persistence/mysql";
import param from "../params";

// returns team ID
export default async function decode(auth: string): Promise<string> {
  if (_.startsWith(auth, "Bearer")) {
    const claims = jwt.verify(auth.split(" ").pop(), await(param("JWT_SIGNING_KEY", "/id/jwt_signing_key", true)));
    return claims.team_id;
  } else {
    const q = `select teamid, name, access_token, is_system_token, last_active, read_only from vendor_team_access_token where access_token = ?`;
    const v = [auth];
    const pool = getMysqlPool();
    const result = await pool.query(q, v);

    if (result.length === 0 || result[0].read_only) {
      return "";
    }

    return result[0].teamid;
  }
}
two of the best fighters in the welterweight division,” said Stephen Espinoza, Executive Vice President & General Manager, SHOWTIME Sports. “We’re in the midst of a de facto ‘welterweight tournament’ – a series of matchups between the best fighters in one of boxing’s deepest divisions. The winner of Berto vs. Porter will land right back in the mix with the top champions at welterweight as we move toward crowning an undisputed 147-pound champion.”

An exciting and accomplished fighter from Florida, Berto represented Haiti in the 2004 Olympics but now trains in Oakland with the renowned Virgil Hunter, who led him to a thrilling victory in April 2016 as Berto scored a fourth-round knockout of former champion Victor Ortiz in their rematch. Berto previously challenged retired legend Floyd Mayweather in


o - 3. Let g(n) = 6*n + 7. Let r(v) = -2*g(v) - 14*u(v). Give r(j).
-10
Let w(b) = 7*b + 6. Let k = 346 + -349. Calculate w(k).
-15
Let t = -5 - -10. Let j(f) = -2 + 2*f - t*f + 8 + f. Let k(c) = c - 2. Let w be k(7). Give j(w).
-4
Let v(t) = t + 3. Let i = 20 + -2. Suppose -20*z + i*z = 0. Determine v(z).
3
Suppose 4*z = -z + 15. Let n(y) = 1 + z*y - y - 3*y + 6. Suppose -3*l + 5 = -16. Calculate n(l).
0
Let s(z) = 27*z + 490. Let q be s(-18). Let h(d) = d**3 - 5*d**2 + 3*d + 2. Calculate h(q).
-2
Let i(l) be the second// dot intention-states.gv -Tpdf -o intention-states.pdf

digraph intention_states {
   compound=true;

   ENTRY[shape=point,color=black,label=""];
   EXIT[shape=point,color=black,label=""];

     node [shape=oval,style=filled,color=gray, fillcolor="lightgoldenrod", fixedsize=shape,width=2];
     R [label=<running
(I,E,SE,SI)>];
     S [label=<suspended
(PI,PE)>];
  	 P [label=<waiting
(PI,PA)>];

     R->S[arrowsize=0.5];
     S->R[arrowsize=0.5];

     R->P[arrowsize=0.5]; //[label=<^resumed>,fontsize="8",arrowsize=0.5];
     P->R[arrowsize=0.5];

	 ENTRY->R[arrowsize=0.5];
   {R,S,P} -> EXIT [arrowsize=0.5];

}


and when you
choose a midpoint m, [a, m) and [m, b) don't overlap. Thinking in these terms
makes implementing e.g. quicksort and binary search much easier.

~~~
nailer
My math is rusty. Could you explain your use of square and regular brackets in
[a, m) and [m, b) ?

~~~
alan-crowe
The common useage in mathematics is in analysis and topology, to specify
subsets of the real numbers. Remembering that _open_ and _closed_ are jargon
terms in topology:

(a,b) is an open set and contains exactly those x such that a is less than x
and x is less than b.

[a,b] is a closed set and contains exactly those x such that a is less than or
equal to x and x is less than or equal to b

For example, one might be thinking about the interval [0,pi] but the function
1/sintime,
and it registers the foo-function in the module namespace. During creating the
foo-function, the default-parameters are evaluated (resulting in a single list
instance), and the results of this evaluation are used as default parameters
in the following. That is also why something like def foo(x = random_value())
is kind of tricky and should be documented.

------
JoelMcCracken
There are probably 10-15 things that really bother me about python, but none
of them are in this list. This list is really pretty darn awful.

My biggest issue with python is its stupid tendency toward imperative
programming in the standard library. For an instance of this irritation, try
running python, then executing dir(<any object you pick>). Then, try
dir(<obj>).sort . Notice anything? Yeah, the f'er sorted it in place, and
didn't return anything. Nice job, library.

I once tweeted that python was a c


in the public switched telephone network. This can provide a form of registration which allows the system to route incoming calls to a roaming user. It can also allow the user to declare the device at which they can be found and allow the system to supply the user with their preferred features at that device.
The '377 Patent was developed to provide services to a single device. Today, however, users are often associated with multiple devices. For example, a user can have a cell phone, a residence telephone, an office telephone, etc. The provision of multiple devices extends the scenario in which the '377 Patent can be used, which as disclosed within the present application can maintain multiple devices that are permanently associated with the user but canspecification and claims herein refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. Examples of such dosage unit forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, injectable solutions or suspensions, teaspoonfuls, tablespoonfuls and the like, and segregated multiples thereof.
Preferably, a therapeutically effective amount of the pharmaceutical composition comprising a farnesyl protein transferase inhibitor is administered orally or parenterally. Said therapeutically effective amount is the amount that effectively decreases the severity of arthritis, i.e. dimishes the swelling and the tenderness of the joints and reduces the pain, or the amount that reduces the incidence, i.e. the number of swollen and tender


and that means taking a bunch of pills.

Are Toxins Making You Fat? Time for a natural cleanse or detoxification.

Could toxins be contributing to your weight gain and to your difficulty in losing weight? Well, I think they are very likely. Let’s just talk about a few different ways in which they can.

First of all, we use a lot of different pesticides and preservatives in your food supply. And unless you are eating 100% pure foods that have been grown away from civilization, you probably have accumulated a lot of those.

Also from automobile exhaust, from various kinds of paints and chemicals that are used around the home and at work for spraying, for insecticides, and all sorts of industrial locations, even if you don’t spray at home.

All of theseThe plaintiffs’ argument begs the question of whether the legislature
can
 modify joint and several liability. Plaintiffs have cited no authority for the proposition that such a change is not the legislature’s prerogative. In both of the above decisions, we recognized certain policies in favor of joint and several liability. We did not hold that no policies supported modifying the rule or that the legislature is powerless to act in this area. Accordingly, we reject plaintiffs’ argument that section 2–1117 is invalid on this basis.

V. Arbitrary Elimination of a Common Law Remedy

Plaintiffs next argue that section 2–1117 is unconstitutional as an arbitrary abolition of an established common law remedy. Plaintiffs rely on article I, section 12, of the Illinois Constitution, which provides that “[e]very person shall find a


Thus, Marlin’s “certain remedy” in this case is that his employer paid his workers’ compensation benefits, all of his past and future medical expenses will be paid, and Kraft will pay its proportionate share of the nonmedical damages. Plaintiffs’ argument suggests that anything less than full payment of workers’ compensation benefits and full payment of a tort judgment by a 1% responsible defendant is not a “certain remedy” for all injuries and wrongs suffered by Marlin. We cannot agree. The legislature did not arbitrarily abolish a remedy in section 2–1117, as plaintiffs suggest. Rather, the legislature merely determined how judgments would be paid and determined that minimally responsible defendants should not be required to pay entire judgments.

VI. Special Legislation and Equal Protection

Plaintiffs next contend that section 2–1117 violatesstated in its preamble that “ ‘it is the public policy of this State that a defendant should not be liable for damages in excess of its proportional share of fault.’ ”
Best
, 179 Ill. 2d at 432, quoting Pub. Act 89–7, Preamble, eff. March 9, 1995.

We disagree with plaintiffs’ contention that
Best
 is controlling. Unlike with the amended version of section 2–1117, we find that the legislature had a rational basis for excluding medical malpractice cases from the 25% rule in the original version of section 2–1117. As set forth above, Representative Greiman explained that joint and several liability was preserved in medical malpractice cases because the legislature had recently passed medical malpractice legislation and wanted to see how the legislation worked before making other changes. Representative Greiman further


several liability is an inherently unfair doctrine, this conclusion does not end the constitutional inquiry. A statute may be upheld under rational basis review “if any set of facts can reasonably be conceived to justify” (
Jacobson v. Department of Public Aid
, 171 Ill. 2d 314, 324 (1996)) the statute. Accordingly, the rationality of other possible justifications for the modification of joint and several liability set forth in section 2–1117 must be addressed.

One justification that has been frequently advanced for “threshold” statutes, such as section 2–1117, is that these statutes help eliminate elements of unfairness found in the civil justice system that are caused by factors other than joint and several liability itself. See,
e.g.
, Restatement (Third) of Torts: Apportionment of Liability §D18, Comment
c
, at 221 (2000) (theadoption of comparative responsibility, so that the plaintiff may also be legally culpable, imposing the risk of insolvency on an innocent plaintiff is unwarranted.” Restatement (Third) of Torts: Apportionment of Liability §17, Comment
a
, at 148-49 (2000).

Cf
. Restatement (Third) of Torts: Apportionment of Liability §§C18 through C21 (2000); Unif. Comp. Fault Act §2, 12 U.L.A. 39 (West Supp. 1990).

Nevertheless, whatever the policy shortcomings of section 2–1117, the modification of joint and several liability undertaken in the statute is rationally related to addressing the problem of compromise verdicts. See Restatement (Third) of Torts: Apportionment of Liability § D18, Reporters’ Note, Comment
c
, at 226 (2000) ( if low-fault-percentage jury verdicts “are perceived to be a problem, a threshold for joint and several liability would be the appropriate solution”); 22


a third-party plaintiff who obtained the judgment, as will universally be the case in the real world, then the allocation provisions of section 2–1117 should not include the plaintiff’s employer.” (Emphasis in original.)
Lilly,
289 Ill. App. 3d at 1116.

Reasoning further, the
Lilly
court said:

“Turning to defendants who are immune from suit, such as the plaintiff’s employer, the State of Illinois, and others, what is the practical effect of eliminating them from the allocation equation? First, as we indicated earlier, if for some unfathomable reason an immune defendant does not raise its immunity and is subjected to a judgment, then the allocation provisions of section 2–1117 would properly include that defendant’s fault in the equation. This result would be fair to all parties because as the plaintiff isOverexpression of alcohol dehydrogenase or pyruvate decarboxylase improves growth of hairy roots at reduced oxygen concentrations.
Overexpression of Arabidopsis thaliana genes for the fermentation enzymes, alcohol dehydrogenase and pyruvate decarboxylase, improved the tolerance of A. thaliana hairy roots to low oxygen conditions. Whereas the specific growth rate of untransformed hairy roots in shake flasks and in a multiple-tube recirculation bioreactor declined significantly with decreasing oxygen tension down to 25% air saturation, growth of the transformant root lines was maintained at rates similar to those achieved with full aeration. This work demonstrates that altering the expression of selected genes involved in anaerobic metabolism can alleviate the problems of oxygen deficiency in hairy root cultures caused by poor mixing and mass transfer conditions.


A refresher on major tax law changes for small-business owners

The dawning of 2019 means the 2018 income tax filing season will soon be upon us. After year end, it’s generally too late to take action to reduce 2018 taxes. Business owners may, therefore, want to shift their focus to assessing whether they’ll likely owe taxes or get a refund when they file their returns this spring, so they can plan accordingly.

With the biggest tax law changes in decades — under the Tax Cuts and Jobs Act (TCJA) — generally going into effect beginning in 2018, most businesses and their owners will be significantly impacted. So, refreshing yourself on the major changes is a good idea.

Taxation of pass-through entities

These changes generally affect owners of S corporations, partnerships and limited //Physics BadGuy
    BadGuyCircle.physicsBody = SKPhysicsBody(rectangleOfSize: BadGuyCircle.size)
    BadGuyCircle.physicsBody?.categoryBitMask = Numbering.Badguy
    BadGuyCircle.physicsBody?.contactTestBitMask = Numbering.Laser
    BadGuyCircle.physicsBody?.affectedByGravity = false
    BadGuyCircle.physicsBody?.dynamic = true

    self.addChild(BadGuyCircle)

I want it so that the bad guy is removed from the parent if 2 bullets are made in contact with the bad guy.
I got it so that when 1 bullet makes contact with the enemy, it is removed from the parent.  (here is the code)
func didBeginContact(contact: SKPhysicsContact) {
    let A : SKPhysicsBody = contact.bodyA
    let B : SKPhysicsBody = contact.bodyB

    if (A.categoryBitMask == Numbering.Badguy) && (B.categoryBitMask == Numbering.Laser) || (A.categoryBitMask == Numbering.Laser) && (B.categoryBitMask == Numbering.Badguy)
    {


       badGuy.badGuyBulletCollisionsCounter += 1
        runAction(BadGuyLostSound)
        bulletsTouchedBadGuy(badGuy, Laser: B.node as! SKSpriteNode)
    }
}

In the bulletsTouchedBadGuy method :
func bulletsTouchedBadGuy(badGuy: BadGuy, laser: SKSpriteNode){
    nodesToRemove.append(laser)
    if badGuy.badGuyBulletCollisionsCounter == 2 {
       nodesToRemove.append(badGuy)
    }
}

Finally:
override func didFinishUpdate()
{
     nodesToRemove.forEach(){$0.removeFromParent()}
     nodesToRemove = [SKNode]()
}

War
Maryland Civil War Confederate units
Maryland Line (CSA)

References
Booth, George W., Personal Reminiscences of a Maryland Soldier in the War Between the States, 1861-1865. Lincoln, NE: U NE press, 2000 reprint of 1898 ed.
Ernst, Kathleen. Accompanied by Cries of 'Go It, Boys! Maryland Whip Maryland! Two 1st Marland Infantries Clashed. America's CW. July 1994: pp. 10, 12, 14 & 16.
Field, Ron, et al., The Confederate Army 1861-65: Missouri, Kentucky & Maryland Osprey Publishing (2008), Retrieved March 4, 2010
Goldsborough, W.W., p. 285-91, Grant's Change of Base: The Horrors of the Battle of Cold Harbor, From a Soldier's Notebook. Southern Hist Soc Papers 29 (1901)
 Goldsborough, W. W., The Maryland Line in the Confederate Army, Guggenheimer Weil & Co (1900), .
Howard, McHenry. Recollections of a Maryland Confederate Soldier and Staff Officer Under Johnston, Jackson


to have an influence on resulting PEC structure like: ionic strength of the PEC production solution; embedding of particles, age of PEC stored in solution prior to processing, molecular weight of the PE and pH of the production solution will be addressed in subsequent publications. Please note that throughout this publication the word "mould" is used for micro-structured Poly(dimethylsiloxane) (PDMS, silicone rubber) since the PEC structuring is a casting process with small applied pressure. This nomenclature is kept despite the PEM microcontact printing using the same PDMS patterns as "stamps".

Results
=======

Micro-structured PDMS mould
---------------------------

PDMS moulds for microcontact printing were produced by casting a curable PDMS precursor onto a silicon master, curing PDMS and lifting it off, similar to ref. [@b27] (see also Methods and materials as well as and SIFig. S1(a)](#S1){ref-type="supplementary-material"}. Silicon masters with three types of surface features were used in this work: (1) blunted spherical cones 4 μm tall, with larger and smaller base diameters of 10 and 7 μm, respectively, and 20 μm pitch size; (2) an array of blunted cones 10 μm tall, with 5 μm diameter of the larger base and smaller top base shaped as a square having 3 μm edges, the top pitch size is 2 μm; (3) 10 μm tall truncated square pyramids, having larger and smaller base edges of 14 and 10 μm, respectively, and 2.5 μm top pitch size. Examples of PDMS moulds from these master structures can be observed in [Supplementary Information Fig. S1](#S1){ref-type="supplementary-material"}.

PEC complexes
-------------

All PE solutions were prepared at a concentration of 2 g/L using an ionic strength of 2 M NaCl (for PAA-PAH and PSS-PDDA PEC


assess their hazardous properties and classify and label them are not available. In our view, a decision should be made as soon as possible that after the last time limit for data requirements that has already been decided (year 2018), data requirements similar to those currently required for substances produced or imported in quantities of ≥ 10 metric tons/year will be introduced for all substances produced or imported in quantities of 1--10 metric tons yearly. Only then are we approaching a situation when the principle "no data, no market" can be said to have been realized. At the same time, a thorough evaluation needs to be made of the exclusion of substances produced or imported in quantities of \< 1 metric ton/year from the legislation, and ways toa non-linear relationship between a male's copulatory success and female fecundity. Females mating males that obtain few (<2) or many (>6) matings enjoy increased fecundity. The basis for these relationships between male mating success and female fecundity is not known but may be based on sex-peptides passed to the female during copulation. Such direct benefits may help explain the lek mating system and the evolution of female choice in this species.

All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.


Survival outcomes for lung cancer, the leading cause of cancer-related mortality in the United States, remain poor. Improving lung cancer survival requires a multi-pronged approach, including smoking cessation and better elucidation of gene-environment interactions in risk, identification of new promising drug targets, as well as identification of potential prognostic and predictive markers that optimize treatment for patients. Our molecular epidemiology group has investigated the role of candidate germline polymorphisms and survival in lung cancer since the 2002 initiation of this study, and we have made significant contributions to understanding genetic and other markers of NSCLC survival. In this competing renewal, we will employ high- density genome-wide genotyping and epidemiologic approaches to identify better prognostic and predictive genetic markers of NSCLC survival. The ultimate goal of identifying such markersloop leading to the changed way of calcium coordination and decreased Ca^2+^-binding affinity \[[@B43-ijms-21-05879]\]. Although amino acid sequences of S100 proteins (and S100 domains of basalin and hornerin) are rather diverse (for human S100 proteins, sequence identity ranges from 12.5% to 94.1%, with mean sequence identity of this protein group being 30.6 ± 9.9%, see [Supplementary Materials](#app1-ijms-21-05879){ref-type="app"}), these proteins are known to possess remarkable structural similarity. In fact, structures of all the S100 subunits characterized so far represent a four-helix bundle. However, the only monomeric representative of human S100 family is S100G (calbindin-D9k, also known as intestinal vitamin D-dependent calcium-binding protein), whereas the majority of S100 proteins exist as a symmetric homodimer, which is held together by the noncovalent interactions between two helices from each subunit (helices I,