delivery
-------------

CsA was diluted in saline and was given orally by gavage for 5 days before cerebral I/R at a total volume of 15 mg/kg/day (15 mg/kg was based on published pharmacokinetic studies of CsA). CsA concentrations were determined before cerebral I/R in whole blood by high-performance liquid chromatography. For the Control group, an equal volume of saline was administrated.

Body weight
-----------

The body weight of rats was measured at the following times: 5 days prior to surgery, 2 days prior to the ischemic insult, and on the day of surgery.

Surgical procedure
------------------

Rats were fasted but were given free access to water 12 h prior to surgery, and neural defect scores were assessed to identify rats with congenital neural dysfunctions. A combination of preanesthetic agents containing ketamine (50--100 mg/Kg) and xylazine (1--5China. All samples were run in 96-well plates. The optical density (OD) was measured spectrophotometrically at a mean wavelength of 450 \[[@b2-medscimonit-25-1637]\] nm. The OD value is proportional to the concentration of S100B.

Statistical mode of analysis
----------------------------

Normal distribution was confirmed using histogram plots, box plots, and the Shapiro-Wilk test. Continuous data are presented as means \[SEM\]. Categorical variables were compared using the two-sided Fischer's exact test. We employed the two-tailed *t* test to compare continuous variables. Correlations were analyzed using Pearson correlation coefficients. A p-value of less than 0.05 was considered statistically significant. Data analyses were performed using SPSS version 17.0.

Results
=======

Body weight
-----------

At baseline time (ie, 5 days before cerebral I/R) no significant differences were observed in rat weights between the Control I/R group and the Cyclosporine I/R group (mean


brain
--------------------------

The HE-stained micrographs showed neuropathological changes. The classic appearance of acute neuronal degeneration was 'eosinophilic neurons' (also termed 'red' or 'red dead' neurons), which were characterized by cell body shrinkage, darkly stained pyknotic nuclei, and an intensely stained red eosinophilic cytoplasm ([Figure 3A--3C](#f3-medscimonit-25-1637){ref-type="fig"}).

Infarct size measurement
------------------------

Infarct size was assessed at 24 h after ischemia. Results are reported as intensity of staining density in both ipsilateral and contralateral hemispheres ([Figure 3D](#f3-medscimonit-25-1637){ref-type="fig"}). Comparison infarct sizes between the 2 groups showed that the percentage of brain tissue necrosis was significantly lower in Cyclosporine I/R rats compared with Control I/R rats (5.9% \[2.3\] *vs.* 13.4% \[1.9\], p=0.025) at the coronal level 1 mm anterior to the bregma. Likewise, at the coronal level 1 mm posterior to the bregma, the brain infarct size was0.21 \[0.02\], p=0.095 and 0.58 \[0.10\] *vs.* 0.21 \[0.03\], p=0.0018, respectively). On the other hand, S100B protein was higher in the Control I/R group than in the Cyclosporine I/R group at t1 (0.23 \[0.04\] *vs.* 0.21 \[0.02\]). This difference, however, was not statistically significant p=0.57 ([Figure 5A](#f5-medscimonit-25-1637){ref-type="fig"}).

Step-by-step, the percentage of change in the S100B protein was significantly higher in the Cyclosporine I/R group than Control I/R group (140 \[43.8%\] *vs.* 0.66 \[13.6%\]) in the period between (t1) and (t2) p=0.0069, as well as in the period between (t0) and (t2) (117 \[45%\] *vs.* 0.69 \[9.7%\], respectively, p=0.022). Additionally, the absolute difference in the S100B protein levels was slightly higher in the Cyclosporine I/R group in comparison with the Control I/R group (−14.7 \[6.4%\] *vs.* 13.6 \[16.4%\], respectively) between


Wasteland 2 by inXile entertainment Kickstarter update #4 features Brian Fargo channeling his inner Billy Joel to explain "We didn't start the fire." He says that while they are on the verge of the $1.5 million funding level that will permit them to create Linux and OS X editions of Wasteland 2, he does not foresee making console editions of the post-apocalyptic RPG sequel: "It is imperative that we deliver the core PC experience that the fans are expecting here and I want to avoid any elements that could distract us. The console interface is quite different when you consider the input device and proximity to the screen whereas the Mac and Linux are pretty much identical to that of the 'PC'. We will consider a tablet versiondue to the similarity of the screen and interface but even on that we need to do a bit more research." He also proposes a little Kickstarter socialism to help share the tremendous support some projects are receiving:

And speaking of goodwill it occurs to me that we can harness the power of Kickstarter in a more meaningful way. Fan funding is bigger than me or Wasteland 2 as I have remarked before. The development community has come together to support us in ways that I didn't think possible and our power as developers will ultimately come from us sticking together. Both gamers and developers have so much more strength than they realize. But in order to help facilitate the power of crowd funding I am going to suggest


all he wanted to do was clear things up. At this time, appellant made his second written statement which was later admitted into evidence at trial.
Appellant's father, James Harville, testified that he saw appellant in Montemayor's presence shortly after the second statement was made. When Harville asked his son why he had made the statement, appellant said that Montemayor had told him, "Look, son, we already have enough on you to send you to the electric chair, so if you go ahead and sign the statement, it will go easier for you." Harville related that when appellant made this statement, Montemayor nodded in agreement with what appellant had said.
Appellant testified that while Montemayor was questioning him, he was told that if he did not sign the statement, heRoberts leave the bar in a truck. Appellant then went to his brother's home and asked him to state that he had been there all night if questioned by anyone.
While appellant's confession may not be a full admission of the offense of murder, we find that when his statement and the evidence presented at trial are considered together, there is direct evidence of his commission of the offense. See, Williams v. State, supra; Knight v. State, Tex.Cr.App., 538 S.W.2d 101. Thus, appellant's contention that the State relied solely upon circumstantial evidence to prove his guilt is without merit.
We find the evidence sufficient to support the conviction.
In his last ground of error, appellant contends that his court-appointed attorney was not given ten days to prepare for trial.
The record reflects


 "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "combined"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### We need to shuffle the values in the combined array"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {
    "collapsed": false,
    "run_control": {
     "read_only": false
    }
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
        "    \n",
      "    Returns\n",
      "    -------\n",
      "    None\n",
      "    \n",
      "    Examples\n",
      "    --------\n",
      "    >>> arr = np.arange(10)\n",
      "    >>> np.random.shuffle(arr)\n",
      "    >>> arr\n",
      "    [1 7 5 2 9 4 3 6 0 8]\n",


Tag: unique wine tasting near Cape Town

Cape Town is blessed with all sorts of wine tasting experiences – with everything from chocolate or biltong tastings to vineyard safaris and everything else in between… These delicious experiences, exceptional wine farms and top-class wines are enough to convert even the most stubborn ‘I’m not really a wine person’ into a true wine appreciator. But sometimes, the city’s best kept […]the form $$\begin{aligned}
{\bf a}=\frac{(\q^2-2\p\q+q_4^2)^2+4q_4^2\epsilon_\p^2}
{(\q^2+2\p\q+q_4^2)^2+4q_4^2\epsilon_\p^2} \,,\qquad
{\bf b}=\frac{(\q^2+q_4^2)^2-4(\p\q+iq_4\epsilon_\p)^2}
{(\q^2+q_4^2)^2-4(\p\q-iq_4\epsilon_\p)^2}\end{aligned}$$ and are rather typical for such calculations.

At first it is useful to find the long wavelength limits of both longitudinal and transverse spectra remaining in the framework of the one-loop approximation and making the standard analytical continuation. In this case $\Re \Pi_{44}(\omega,\q)$ and $\Re
A(\omega,\q)$ should be expended in powers of $|\q|$ (keeping $\omega \ne 0$) $$\begin{aligned}
-\Re \Pi_{44}(\omega,|\q|\rightarrow 0)=\frac{\q^2}{\omega^2}
(\omega_0^2+ b_L\frac{\q^2}{\omega^2})\,,\qquad \Re A(\omega,
|\q| \rightarrow 0)=\omega_0^2+b_T\frac{\q^2}{\omega^2}\end{aligned}$$ and in this form they are used to solve Eq.(8). Here new abbreviations are: $$\begin{aligned}
\omega_0^2&=&\frac{e^2}{\pi^2}\int\frac{\p^2d|\p|}{\epsilon_\p}
(n_\p^++n_\p^-)(1-\frac{\p^2}{3\epsilon_\p^2})\,, \nonumber\\
b_L &=&\frac{e^2}{\pi^2}\int\frac{\p^2d|\p|}{\epsilon_\p}
(n_\p^++n_\p^-)\frac{\p^2}{\epsilon_\p^2}(1-\frac{3\p^2}{5\epsilon_\p^2})\end{aligned}$$ and $ b_T=b_L/3 $ . Finally the long wavelength limits of the collective photon excitations have the form $$\begin{aligned}
\omega_L^2(\q)=\omega_0^2+\frac{b_L}{\omega_0^2}\q^2 \,,\qquad
\omega_T^2(\q)=\omega_0^2+(1+\frac{b_T}{\omega_0^2})\q^2\end{aligned}$$ and demonstrate that these spectra have a gap and are split at finite momenta. This gap is a dynamical photon mass which


is always nonzero in the medium.

Now we continue to find the photon spectra for any momenta but only in the high temperature limit considering that $T>>m,\mu$. To this end we replace $|\p|$ by $|\p|T$ inside all integrals within Eqs.(11) and (12) and simplify them keeping only the leading terms. Then the dispersion relations will be solved using these simplified integrals.

Our result when $m\ne$ 0 is two rather complicated integral equations which are separated for the longitudinal mode $$\begin{aligned}
\omega_L^2(\q)=\xi^2\frac{e^2}{\pi^2}\int\frac{\p^2d|\p|}{\epsilon_\p}
(n_\p^++n_\p^-)\Bigr[\,\frac{\xi d_\p}{2}\ln\frac{(1+\xi d_\p)^2}
{(1-\xi d_\p)^2}-\frac{d_\p^2(1-\xi^2)}{1-\xi^2d_\p^2}-1\,\Bigr]\end{aligned}$$ and for the transverse excitations $$\begin{aligned}
\omega_T^2(\q)=\xi^2\frac{e^2}{\pi^2}\int\frac{\p^2d|\p|}{\epsilon_\p}
(n_\p^++n_\p^-)\Bigr[\,\frac{\xi^2}{\xi^2-1}-\frac{\xi
d_\p}{4}\ln\frac{(1+\xi d_\p)^2} {(1-\xi d_\p)^2}\,\Bigr] \,.\end{aligned}$$ Here $ d_\p=\epsilon_\p/|\p| $ and the variable $\xi=iq_4/|/q|$ runs in $1<\xi<\infty$ . The long wavelength limit corresponds to $\xi\rightarrow\infty$.

To find these limits one should expand in powers of $1/\xi\,$ Eq.(17) and (18) and then replace $\xi^2$ aswhere the bare Green functions are used to calculate Eq.(27) and the Feynman gauge is usually fixed to make all calculations more simple. Within this approximation any results found for the collective Fermi excitations in QED will be the same as the results established earlier for QCD in \[6\], if the factor $(N^2-1)/2N$ is omitted everywhere in these papers. However we briefly repeat these results to solve our task more completely.

After all calculations have been performed, the one-loop $\Sigma(q)$ in QED is given by $$\begin{aligned}
&&\!\!\!\!\!\!\!\!\!\!\!\!\!\!\!\Sigma(q)=
-e^2\int\frac{d^3p}{(2\pi)^3}\;\left\{\;\Bigr[
\frac{1}{\epsilon_\p}\;\frac{n_\p^+\;[\gamma_4\epsilon_\p+(i\g\p+2m)]}
{[q_4+i(\mu+\epsilon_\p)\;]^2+(\q-\p)^2}\right.\nonumber\\
&&\!\!\!\!\!\!\!\!\!\!\!\!\!\!\!\!\!\! \left.+\;\frac{n_\p^B}{|\p|}
\;\frac{(|\p|+\mu-iq_4) \gamma_4-[i\g(\q-\p)+2m]}{[q_4+
i(\mu+|\p|)\;]^2+\epsilon_{\p-\q}^2}\;\Bigr]
-\Big[h.c.(m,\mu)\rightarrow-(m,\mu)\Big]\right\}\end{aligned}$$ where $\epsilon_\p=\sqrt{\p^2+m^2}$ is the bare electron energy; $n_\p^{B}=\left\{\exp\beta|\p|-1\right\}^{-1}$ and $n_\p^{\pm}=
\left\{\exp\beta(\;\epsilon_\p \pm \mu)+1\right\}^{-1}$ are the Bose and Fermi occupation numbers, respectively.

Further two new functions are introduced and one can rewrite the expression (28) as follows $$\begin{aligned}
\Sigma(q)=i\gamma_{\mu}K_{\mu}(q)+m\;Z(q)\end{aligned}$$ that is necessary to find nonperturbatively


KDS to
(1) distribute Broadscape's Webscape software with KDS monitors modified to work with the Webscape software; and
(2) fund rebates to purchasers of those modified monitors.
The second contract, dated March 6, 2000, referred to as the "Financing, Rebate and Supply Agreement" was perfected. It required
(1) KDS to distribute Broadscape's Myscape software on a compact disc with the sale of 2,000,000 KDS monitors;
(2) KDS to provide Broadscape with financing in the amount of $900,000.00, payable in 12 monthly installments of $75,000.00 per month;
(3) Broadscape to provide KDS with the option to fund additional rebates on additional modified monitors;
(4) Broadscape to pay KDS for these requirements with Broadscape stock; and
(5) Broadscape to grant KDS exclusive rights to Broadscape's technology.
In May 2000, Broadscape initiated arbitration proceedings seeking specific performance of both contracts,break;
        }
        if (num[0] == reverse[9] && num[1] == reverse[8] && num[2] == reverse[7] && num[3] == reverse[6] && num[4] == reverse[5])
            System.out.println("The sequence is palindromic.");
        else
            System.out.println("The sequence is not palindromic.");
    }
}

No build messages however, it always says that the sequence is palindromic regardless of what I input.

A:

You don't need to use the reversed array and compare the elements with it.
try this in your code :
public static void main (String[] args) {
   Scanner scan = new Scanner(System.in);


       = 26  // { int sys_ptrace(int req, pid_t pid, caddr_t addr, int data); }
	SYS_RECVMSG        = 27  // { ssize_t sys_recvmsg(int s, struct msghdr *msg, int flags); }
	SYS_SENDMSG        = 28  // { ssize_t sys_sendmsg(int s, const struct msghdr *msg, int flags); }
	SYS_RECVFROM       = 29  // { ssize_t sys_recvfrom(int s, void *buf, size_t len, int flags, struct sockaddr *from, socklen_t *fromlenaddr); }
	SYS_ACCEPT         = 30  // { int sys_accept(int s, struct sockaddr *name, socklen_t *anamelen); }
	SYS_GETPEERNAME    = 31  // { int sys_getpeername(int fdes, struct sockaddr *asa, socklen_tpid_t pid); }
	SYS_SIGACTION      = 46  // { int sys_sigaction(int signum, const struct sigaction *nsa, struct sigaction *osa); }
	SYS_GETGID         = 47  // { gid_t sys_getgid(void); }
	SYS_SIGPROCMASK    = 48  // { int sys_sigprocmask(int how, sigset_t mask); }
	SYS_SETLOGIN       = 50  // { int sys_setlogin(const char *namebuf); }
	SYS_ACCT           = 51  // { int sys_acct(const char *path); }
	SYS_SIGPENDING     = 52  // { int sys_sigpending(void); }
	SYS_FSTAT          = 53  // { int sys_fstat(int fd, struct stat *sb); }
	SYS_IOCTL


int iovcnt, int pad, off_t offset); }
	SYS_PWRITEV        = 268 // { ssize_t sys_pwritev(int fd, const struct iovec *iovp, int iovcnt, int pad, off_t offset); }
	SYS_KQUEUE         = 269 // { int sys_kqueue(void); }
	SYS_MLOCKALL       = 271 // { int sys_mlockall(int flags); }
	SYS_MUNLOCKALL     = 272 // { int sys_munlockall(void); }
	SYS_GETRESUID      = 281 // { int sys_getresuid(uid_t *ruid, uid_t *euid, uid_t *suid); }
	SYS_SETRESUID      = 282 // { int sys_setresuid(uid_t ruid, uid_t euid, uid_t suid); }
	SYS_GETRESGID      = 283 // { int sys_getresgid(gid_t *rgid, gid_t *egid, gid_t *sgid); }
	SYS_SETRESGID     = 284 // { int sys_setresgid(gid_t rgid, gid_t egid, gid_t sgid); }
	SYS_MQUERY         = 286 // { void *sys_mquery(void *addr, size_t len, int prot, int flags, int fd, long pad, off_t pos); }
	SYS_CLOSEFROM      = 287 // { int sys_closefrom(int fd); }
	SYS_SIGALTSTACK    = 288 // { int sys_sigaltstack(const struct sigaltstack *nss, struct sigaltstack *oss); }
	SYS_SHMGET         = 289 // { int sys_shmget(key_t key, size_t size, int shmflg); }
	SYS_SEMOP          = 290 // { int sys_semop(int semid, struct sembuf *sops, size_t nsops); }
	SYS_FHSTAT         = 294 // { int sys_fhstat(const fhandle_t *fhp, struct


Wilmington, North Carolina - a coastal city accustomed to severe weather - is bracing for an unusually brutal impact. Hurricane Florence will approach the coast of North Carolina and SC on Thursday or Friday.

Popular

Thousands attend funeral for Iran attack dead
Thousands of people packed the streets in the south-western city of Ahvaz on Monday to mourn the victims of the attack. Eight members of Iran's Revolutionary Guard were also killed in one of the worst attacks suffered by Iran in years.

US sanctions China for buying Russian fighter jets, missiles
The US official said Washington had spent "an enormous amount of time" seeking to discourage prospective buyers of Russian arms. All of them - defense related firms, officers of the GRU military intelligence agency, and people associated with the St.

New iPhoneshighest clock) for each device (itemid), so that I can hopefully chart the number of pages each printer has printed thus far.
I've tried running an EXPLAIN for the query which returned the following:
id  select_type         table   type    possible_keys   key         key_len     ref                 rows        Extra
1   PRIMARY             tu1     ALL     NULL


Code Geass: Lelouch of the Rebellion , The Vision of Escaflowne, and Escaflowne: The Movie are coming to Blu-ray and DVD, Funimation announced at its Anime Expo 2016 panel.

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The Vision of Escaflowne and Esclafowne: The Movie will both be available on October 18. The Vision of Escaflowne is getting a collector's edition and two standard Blu-ray and DVD combo packs for part 1 and part 2.There's also a Kickstarter exclusive version of The Vision of Escaflowne Part 1 for those that backed Funimation's Escaflowne Kickstarter . Escaflowne: The Movie features a new dub with "new HD materials."Code Geass will be available on October 4 in a collector's edition that includes season 1 and 2, 16 art cards, and bonus features. The anime will also be available in twofour of the California teachers involved with the purported class action, this is not their first fight against union dues. In 2016, their case went up to the Supreme Court, which split 4-4 after Justice Antonin Scalia’s death and did not issue a ruling.

In Janus, the court overturned a 1977 opinion by determining it was a violation of the First Amendment to require dues from members who disagreed with their public-sector union.

The ruling will affect 22 states that allowed for mandatory union dues. The other 28 states, known as “right to work” states, had previously passed laws banning the practice.

Regarding the newly filed lawsuit, Randi Weingarten, president of the American Federation of Teachers, told the Recorder that Janus does not require the retroactive repayment of union dues.

“As we


VintageModern Design Challenge - Flour Garden Apron

Description

VintageModern Design Challenge

I’ve so much enjoyed creating this apron for the VintageModern Design Challenge. When I saw Amy Barickman’s book, Vintage Notions, I knew I would love looking through it and choosing just the right pattern. Making a pattern using only the measurements given in a Magic Pattern and altering it here and there, was so much fun and has given me a much needed respite from an unusually stressful year.

My “Flour Garden Apron” for the VintageModern Design Challenge, is designed from a Magic Pattern in Amy Barickman’s book, Vintage Notions. I constructed and cut the pattern using the “Comfortable/Economic Apron“ (1926) pattern (pp. 172-173). Then I altered it to suit my more modern preferences.

Though the body of the apron is cutpoet, it doesn’t mean it is has necessarily a effective causal or structural relationship with it. To take a concrete example: a ball and the sun share a spheric-like form but it doesn’t necessarily mean they share a causal relationship.

So yes Avant-gardism leans towards artistic evolution and revolution and so does Planetary life biodiversity, biological growth as Darwin exposed.

But does it mean it has a causal relationship? I wouldn’t be surprised so.

But such a theory is simple to state for the poet but on a scientifically ground it has to be verified and proved thanks to scientific studies. I mean direct scientific studies that can expose a direct and striking causal relationship between the evolutionary biological life and the evolutionary cultural life, at best with avant-garde metal. I


fine and dandy, but one should also take in account the case the millenary traditional music of some cultures. If evolution selection is the reason of the existence of music, how can we explain that some ethnic traditional music who don’t change/adapt survive for over millenaries?

So whatever if we have to take in account every side that might implied in such complex cultural phenomenon, you would need several books.Now my concern was just to define more humbly AGM music on a strict aesthetic issue without necessarily taking in account every latent issue behind the concept of AGM.

If we were to deal extensively with every implication behind each concept, we could not deal with a simple and short definition of that concept anymore.

Here’s the reason why I focus mostparticularly on the aesthetic aspect of the issue. Even though some biological aren’t openly treated within that definition.

Olivier Côté wrote:

Well of course that's fine Fred. I still don't know why you reacted this way. I wasn't intending to go against anyone. You say that you already knew about the hegelian formula of "destroying & surpassing" understood in an evolutionary musical context.

No I didn't. Actually I'm familiar with Hegel (most particularly for his work on music and his thought which influenced musical Romantism thought), but I wasn't familiar with that very hegelian formula itself, I only was with the concept itself.

I was more familiar with avant-garde music philosopher Adorno's stance who worded similar things. But Admitedly he was strongly influenced by Hegel.

Anyway that "destroying & surpassing" thing is kind


about that.

I think it's the same with avant-garde. Britney can tell every journalist that her last album was original and forward-thinking, but who cares if it's not avant-garde at all, once compared to any European techno artist? It's like Nocturno Culto saying that the next Darkthrone album is gonna be "special" and like nothing he's done yet, even that it's maybe gonna shock his fans. Maybe it's different if you compare it to Transylvanian Hunger, but in the end it is nothing else than metal right?

Yeah sure, perspective is an important part of our lives. Everyone's perspective, in some way, can be interesting. But I also believe that the ones who are experiencing everything possibly experiencied in the realm of music, have a more valuable comprehension of musicUnited Methodist Church

References
Thomas, James S. Methodism's Racial Dilemma:  The Story of the Central Jurisdiction. Nashville: Abingdon Press, 1992.
Leete, Frederick DeLand, Methodist Bishops.  Nashville, The Methodist Publishing House, 1948.

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and the experience of the surgeon. HIV infection in itself is not a contraindication to a procedure, and the approach should be individualised based on his or her condition. According to formal society guidelines, dentists are obliged to perform dental extractions and other procedures (in patients with HIV) based on the same criteria used for other patients. Ignorance, fear, or stereotypes are never an excuse.

The ethical and legal perspective should also be considered. HIV equals disability. That means that discrimination against patients with HIV/AIDS is illegal (according to the ‘Equal Rights of Persons with Disabilities Law’, 1998, Israel). Physicians may not refuse to treat individuals with HIV, the same way they cannot decline to provide care to a patient with obesity or a neurodegenerative condition. In addition, physiciansis not allowed except for periods, hyphens, apostrophes, and underscores.

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Using a layered approach is another great way to build a good veggie habit. For example, start with a food you already enjoy — say, pasta — and layer some veggies into your bowl. This can help you explore a new food with one you already love eating, and from there, you can try new ways to savor it. Take spinach, for instance. After trying it with pasta, you may want fold it into an omelet or another favorite food, or explore it on its own with different cooking techniques (sautéed or steamed) or different flavor additions (garlic or golden raisins). The possibilities are limitless!

I knew I would lose weight at Jump Start. I did my homework before attending. What I didn't expect was the level of experiencewasn’t sure if I believed in myself on the same level. Sometimes others see us before we see ourselves and it’s sometimes necessary when we hear from them what we should be telling ourselves all along. Even though I had been telling myself one thing that day - it was there. The desire to want to go for it even though I immediately went for the easier option and didn’t push myself. I’ve never really needed to push myself physically or known how to. But in that moment I just needed a reminder and reason to go for it and he saw me and gave it to me. It’s better to try it and not accomplish it than to not have tried at all so I decided to


be a good fit. Vegans and vegetarians can lose weight by choosing fruits, vegetables, whole grains and plant proteins. Nut lovers may do well shedding pounds with a Mediterranean-style menu. Whatever diet appeals to your appetite and way of life, focusing on whole foods is something that all plans promote.
During the 3 days of the diet, balanced nutrition is lacking. Some of the foods that are recommended are high in salt and fat and would not be appropriate for people with certain medical problems like heart disease, high blood pressure, diabetes, or high cholesterol. You may not be getting enough vitamins, minerals, and fiber while you are on the diet. If you are taking medicine for your diabetes and want to try the 3-day diet, it's important totrial, we found that higher baseline plasma PFAS concentrations were not associated with weight loss induced by energy restriction, but were significantly associated with a greater weight regain, primarily among women, during the follow-up period between 6 and 24 months. In addition, after multivariate adjustment, higher baseline PFAS levels were significantly associated with a greater decrease in RMR during the weight-loss period and a lower increase in RMR during the weight regain period.

Looking for the easiest possible way to lose weight? Grab your pajamas early and log some extra Zzzs! According to researchers, getting eight and a half hours of shut-eye each night can drop cravings for junk food a whopping 62 percent and decrease overall appetite by 14 percent! Mayo Clinic researchers note similar findings: In their


I could no matter how low I couldn't go. I moved my legs shoulder width apart, put my weight on my heels and I hesitantly lowered myself, lower, lower and then I felt the step under me. I stopped mid squat, looked up, and smiled, surprised, “I did it!?!?” He smiled right back and quickly said, “yeah, but now KEEP GOING!” And I raised myself up before lowering myself back down and up and down again and up and down again and did just that- kept going.

Apparently there’s a special ingredient in grapefruit that, when eaten with a form of protein, triggers a fat-burning process and therefore results in weight loss. So, the idea is to start each meal with half a grapefruit, eat lots of protein andhighly educated introduces a distortion of public goods provision, in the sense that uncoordinated policies lead to an inefficiently large supply of the public good. Our results suggest that since German local governments are prevented from adjusting their tax structure in a way that meets the efficiency requirements under fiscal competition, they resort to extending the supply of cultural activities through public subsidization.


The average fitness $\langle w \rangle$ is, $$\label{fitaverage}
\langle w \rangle = w_{+} f_{+} + w_{-}f_{-}\, .$$ Let $N_{+}$, and $N_{-}$ be the number of producers and non-producers, respectively. The total population size is $N\equiv N_{+}+N_{-}$. Although the system size, $N$, is often assumed to be a constant [@Archetti15; @Blythe07], we consider a general case [@Melbinger2010] where the population size varies with the time evolution given by, $$\label{Number}
 \frac{\partial N}{\partial t} =w_{+}N_{+}+w_{-}N_{-} = \langle w \rangle N \, .$$ Agent death, neglected for simplicity, could be readily included in the fitness functions.

If the public goods are shared among all the producers and non-producers equally, the same benefit will be presented to them, leading to the relation, $$\label{wrelation}
w_{+} = w_{-} - p_{0} \, ,$$ where $p_{0}$ ($> 0$) is the cost paidfor the wt cells to induce tumor in nude mice, as illustrated by the pink upside down-triangles. However, the $\Delta$ cell alone gives rise to tumors at a rapid growth rate, as illustrated by the blue squares in Fig. \[fig:tumorvolume\]. As long as a small fraction of $\Delta$ cells is injected into the mice together with wt cells, fast growing tumors are induced in mice (see the purple up-triangles in Fig. \[fig:tumorvolume\]). The tumor grows faster as the fraction of $\Delta$ cells in the total injected cells increases from 0, 10, 50, to 90$\%$ as shown in the inset of Fig. \[fig:tumorvolume\]. It is also remarkable that the tumors grow even faster as the injected cells are composed of 10$\%$ wt and 90$\%$ $\Delta$ cells (green spheres) than is the case


of the ANF promoter and interacts with other transcriptional factors such as; *NKX 2.5* and *TBX5* \[[@CR14]\]. Subsequent studies have explained that *TBX5*, *NKX2-5* and *GATA4* interact during embryonic development and are involved in the regulation of heart developmental processes \[[@CR6],[@CR15],[@CR16]\]. *GATA4* knockout mice produce phenotypes like ventral morphogenesis and heart tube formation \[[@CR5]\].

ASD and VSD are the commonest types of CHD and account for 50% of all cases of CHD. If proper precautionary measures are not taken, these defects result in ventricular dilation and heart failure, and ultimately cause a decrease in life expectancy \[[@CR17],[@CR18]\]. VSD and ASD are defects in the ventricular and atrial septum, the wall dividing the left and right ventricles, and atrium of the heart, respectively. TOF is a congenital heart defect, whichand nearly 1,80,000 children are born with CHD each year in India \[[@CR23]\]. Of these, nearly 60,000 to 90,000 suffer from critical CHD requiring early intervention \[[@CR23]\]. Because of higher rate of consanguineous marriages, frequency of congenital heart disease is very high in Andhra Pradesh state of southern India, compared to rest of India \[[@CR24]\]. In spite of higher number of CHD in India, there are very few studies to find a link between *GATA4* mutation and congenital heart disease. Only two studies with CHD patients were conducted to find the association between few selected *GATA4* SNP with CHD, however, their data was not significant \[[@CR25],[@CR26]\]. Therefore, in the present study we have sequenced the complete coding region including exon-intron boundaries of *GATA4* to elucidate the role of


using PolyPhen-2, PMut and SIFT softwares. Results of all the three analyses strongly indicate that Asp425Asn mutation was pathogenic (Table [5](#Tab5){ref-type="table"}). We analyzed functional significance of splice junction mutation (rs73203482) by ESE finder 3.0 and found that this mutation is present near splice site of exon 1 (ENST00000335135) and intron 1. The data has shown the effect of binding of SFRS6, a splicing factor to the splicing region (Figure [4](#Fig4){ref-type="fig"}). This splicing factor has a role in site selection in alternative splicing. This also explains that the binding of splice enhancer will be affected in the presence of this splice mutation. We computed the functional significance of promoter mutation (promoter region −490 to 100 bp, rs61277615) and found the transcription factor binding in the wild-type and mutant promoter region by CONSITEwild *GATA4*, a pool of microRNA binds strongly with the mRNA. However, this binding affinity of miRNA was altered due to the presence of 3′UTR mutations. Our study strongly predicts that all 3′UTR *GATA4* mutations observed in CHD patients may alter the transcript level in diseased heart and affect the embryonic development of heart.

Conclusion {#Sec18}
==========

Our study identified c.620C\>T mutation in *GATA4* is associated with CHD in South India. Although this mutation reported in healthy individuals of other population. For the first time we are reporting its association with CHD in Indian population. Out of four phenotypes we studied, genetic variations were found to be associated with ASD (rs61277615), VSD (rs804280) and TOF (rs73203482, rs804280). c.620C\>T either independently or combinly associated with CHD. Hence *GATA4* is an important marker


have begun launching initiatives to support these students.

Bloc, an online, mentor-led coding school, for example, gives $500 scholarships to two veterans every week, and in honor of Veterans Day, Bloc is giving out $1,000 scholarships during November. Similarly, New York-based Flatiron School has begun offering up to $25,000 in scholarships for veterans who want to take its online program through a partnership with Operation Code, a nonprofit that helps veterans start coding. Meanwhile in Chicago, nonprofit Code Platoon has begun accepting applications for its first cohort, set to kick off early next year. Code Platoon is designed to make it easy for veterans to become programmers by charging $1,500 tuition -- more than $10,000 cheaper than the coding boot camp tuition average.

“These are the most in-demand jobs inQ:

Turtle attribute not defined

Complete newbie here. Can I know why I got error message (NameError: name 'width' is not defined) when I run this code? Thanks :)
from tkinter import *
from turtle import *

root = Tk()
T = Text(root, root.title("Controls"), height=8, width=60)
T.pack()
T.insert(END, """Right arrow key = move forward\nLeft arrow key = move
backward\nr = turn right\nl = turn left\n
u = pen up\nd = pen down\nh = go home\nc = clear""")

def main():
    width(2)
    speed(0)
    pencolor("blue")
    onkey(up, "u")
    onkey(down, "d")
    onkey(clear, "c")
    onkey(home, "h")
    onkey(lambda: forward(5), "right")
    onkey(lambda: back(5), "left")
    onkey(lambda: left(5), "l")
    onkey(lambda: right(5), "r")


consumption, feed conversion, plasma carotenoid concentrations, and coccidial lesion score. By using two levels of inocula it was demonstrated that the efficacy of each anticoccidial was equal to or greater than 90% in controlling these E. maxima isolates. It was also demonstrated that 25 ppm semduramicin was more efficacious than 66 ppm salinomycin based on improvements in weight gain, feed conversion, plasma carotenoid concentrations, and coccidial lesion control.improve perceptual compression. This feedback loop can be used to tune saliency-based compression as an initially viral video decreases in popularity, or to reduce bandwidth while streaming video to a [360]{}video player.

In this paper, we describe [Vignette]{}, a video storage system that leverages perceptual information to reduce video sizes and bitrates. [Vignette]{}is designed to serve as a backend for large-scale video services, such as content delivery systems or social media applications. [Vignette]{}has two components: a compression scheme, *[Vignette Compression]{}*, and a storage manager, *[Vignette Storage]{}*. [Vignette Compression]{}leverages a new saliency-based compression algorithm to achieve up to 95% lower bitrates while minimally reducing quality. [Vignette Storage]{}uses a simple API to trigger saliency-based compression when needed, allowing applications to trade off between faster traditional compression and [Vignette]{}’s smaller video sizes.


full-frame saliency maps to use as additional input [@8117038], computing saliency models on-the-fly at high computational cost [@5223506], or solving complex optimization problems to allocate video bits [@li2011visual], as the quality of saliency map generation was the limiting factor to deploying perceptual compression. Recent interest in applying machine learning techniques to problems in visual comprehension resulted in accurate saliency prediction models that effectively mimic the human visual system [@bylinskii2016saliency]. Moreover, interest from VR developers in deploying fast and accurate eye tracking for improved VR experiences further improved the accuracy of saliency maps with high quality fixation data, leading to a virtuous cycle of saliency map prediction and improvement [@Whitmire:2016:ESC:2971763.2971771]. The final challenge in closing the gap for deploying perceptual video compression is to design storage systems that manage and support perceptual information.

**Tiled Videoacross the video. Because video storage systems slice videos into short segments (10-20 seconds) for better coding efficiency, these video saliency maps capture aggregate saliency information without oversaturating the saliency heatmap.

Leveraging Saliency With Tiled Video Encoding {#subsec:tiles}
---------------------------------------------

Once a saliency map for each video is produced, we then use it to perceptually encode videos with the tiling feature in [hevc]{} [@hevc]. To produce saliency-based tiled video encoding, we divide a video segment spatially into tiles and then map each tile to a quality setting. The saliency map’s value at each tile determines the tile’s quality setting. For simplicity and generality, the tiling patterns we use are rectangular tiles with uniform width and height across the video frame. We use the same tile configuration throughout the entire 10-20 second video


recognition. These applications optimize for different QoS metrics: perceptual quality for entertainment video, and throughput and accuracy for object recognition.

![Results of perceived quality preference user study, averaged across participants and videos by bitrate. Participants either preferred [Vignette]{}or perceived no difference between 20 Mbps [hevc]{}videos and [Vignette]{}videos at 5–20 Mbps.[]{data-label="plot:user-study"}](user-study.pdf){width="\linewidth"}

**Perceptual Quality User Study:** We ran a user study to quantify viewer perception of our saliency-based compression. The study presented users with two versions of the same video: one encoded with [hevc]{}at 20 Mbps, the other with [Vignette Compression]{}. The [Vignette Compression]{}videos were randomly chosen to be either 1 Mbps, 5 Mbps, 10 Mbps, or 20 Mbps. The study asked users their preference between the matched pairs for 12 videos. The bitrate of the [Vignette Compression]{}video varied randomly  Average
        Speedup        (Decode + YOLO)     Accuracy
   34.6% $\pm$ 14.3%   2.6% $\pm$ 2.2%   84% $\pm$ 14%
  ------------------- ----------------- ---------------

  : [Vignette]{}Speedup and Accuracy Compared to [hevc]{}Baseline on YOLO Object Recognition.[]{data-label="table:yolo"}

Compute Overhead
----------------

[Vignette Compression]{}bears the additional processing overhead of executing a neural network to generate or update saliency maps. [Vignette Storage]{}can switch between an exhaustive or more computationally-efficient heuristic tile configuration search to uncover optimal tile configurations for a video. We benchmarked the latency of the combined saliency and transcoding pipeline in two modes: exhaustive, which generates saliency maps per frame and exhaustively evaluates tiling, and heuristic, which uses the heuristic search


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The quintet can start, stop, and shift with the skills of Lack of Interest, bruise bodies and eardrums by way of Crossed Out breakdowns, and stealthily slip a knife under your guard a la Slap A Ham's finer satirists." - INVISIBLE ORANGES PRE-ORDERwere not equipped with their body worn cameras during their shift,” the statement said. “Video of the incident was discovered at a nearby location and was recovered by detectives.”

Police said officers opened fire on 27-year-old Ronald Clark on Saturday because they feared he was reaching for a weapon after officers Tasered him.

Officers first confronted Clark and about two dozen other people around 8:20 p.m. in the 2100 block of W. Spring Street where the group was drinking in public, according to police.

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The devil is in the D tales. While politicians squabble, physicians and pharmacists are forced to advise seniors on Part D despite being unprepared.
The enrollment period for Medicare Part D ended on May 15, but the controversy is far from over. While politicians bickered, pharmacists and physicians like Jeffrey Kerr, left, have been forced to play the role of adviser to confused patients--a role doctors aren't sure they are prepared to fill because of their own lack of resources about the benefit. "We've had to do a lot of this work ourselves," Kerr says.---
abstract: 'We consider random dynamical systems such as groups of conformal transformations with a probability measure, or transversaly conformal foliations with a Laplace operator along the leaves, in which case we consider the holonomy pseudo-group. We prove that either there exists a measure invariant under all the elements of the group (or the pseudo-group), or almost surely a long composition of maps contracts exponentially a ball. We deduce some results about the unique ergodicity.'
address:
- 'IHES - 35, Routes de Chartres - 91440 Bures sur Yvette - France'
- 'UMPA - CNRS UMR 5669 - ENS Lyon - 44, allée d’Italie - 69007 Lyon - France'
author:
- 'Bertrand Deroin & Victor Kleptsyn'
title: Random conformal dynamical systems
---

[^1] [^2]

Introduction
============

Given a probability measure on the group of homeomorphisms of a manifold, one can study


for the pseudo-group of a foliation, and then studied by Ghys [@Ghys2; @Ghys3], Kaimanovich [@Kaimanovich], Ledrappier [@Ledrappier] and Candel [@Candel]. Following the lines of the “Sullivan’s dictionary”, one can extend these ideas to other pseudo-groups, like for instance the one generated by an endomorphism or a correspondance.

In this work we study random compositions of the elements of a pseudo-group acting conformally on a manifold. Our results concern actions of a group by conformal transformations, conformal correspondences or transversely conformal foliations (for one dimensional dynamical systems, we suppose that the maps are of class $C^1$); most of them were known in the case of a group acting conformally on a compact manifold, when the conditional probabilities do not depend on the point (see [@Furman]).

Observe that the existence of a measure which is invariant bythe leaves are complete and of bounded geometry, the solution to the heat equation is unique, defined for all positive time, and is expressed by convolution of the initial condition with the heat kernel $p(x,y;t)$. A fundamental Lemma due to Garnett (see also Candel [@Candel]), asserts that the functions $f(\cdot,t)$ on $M$ are continuous, and that the diffusion semi-group of operators $D^t$ defined for all $t\geq 0$ by $$D^t f(0,\cdot) = f(t,\cdot)$$ acts continuously on $C^0(M)$.

Associated to this diffusion semi-group, Garnett considers the Brownian motion along the leaves of the foliation: this is a Markovian process with continuous time, whose trajectories stay every time in the same leaf, and whose transition probability distributions are volume forms with leafwise density given by the heat kernel. It is known that this


T_i$ to $B_j\times T_j$ are of the form $$(x_i,t_i)\mapsto (x_j=x_j(x_i,t_i), t_j(t_i)).$$ The maps $t_j(t_i)$ generates a pseudo-group on the union $T=\cup_i T_i$, called the holonomy pseudo-group. A measure on $T$ which is invariant by the holonomy pseudo-group is called a *transversely invariant measure*. These measures have been introduced by Schwartzman for flows [@Schwartzman], by Plante and Ruelle-Sullivan for foliations [@Plante; @Ruelle-Sullivan] and by Sullivan for other kind of dynamical systems [@cycle].

Now, consider a continuous path $\gamma$ contained in a leaf, parametrized by a closed interval. It crosses successively the foliation boxes $B_{i_1}\times T_{i_1},\ldots,B_{i_k}\times
T_{i_k}$. The composition of the associated change of transverse coordinates is by definition the holonomy map $h_{\gamma}$ corresponding to $\gamma$. The following result describes the asymptotic behaviour of the holonomy maps $h_{\gamma|_{[0,t]}}$ when $t$ goes to infinity, for aproof.
--------------------------

In [@Garnett], Garnett studies the ergodic properties of the leafwise diffusion semi-group and of the leafwise Brownian motion. She introduces the notion of *harmonic measure*, which is a probability measure invariant by the diffusion semi-group. By the Kakutani fixed point Theorem, such a measure exists. The relation with the Brownian motion goes as follows. Consider the space $\Gamma$ of all the continuous paths contained in a leaf of $\mathcal F$. There is a semi-group $\{\sigma_t\}_{t\geq 0}$ of transformations of $\Gamma$ defined for every $t,s\geq 0$ and every $\gamma \in \Gamma$ by $$\sigma_t(\gamma) (s) = \gamma(t+s).$$ If $\mu$ is a measure on $M$, then one consider the probability measure $\overline{\mu}$ on $\Gamma$ which is defined by $$\overline{\mu} (B) = \int _M W_x(B\cap \Gamma_x) d\mu(x),$$ for every Borel subset $B$


same for the points close enough on the same leaf of ${\mathcal{F}}$ and for the points close enough on the same leaf of ${\mathcal{G}}$. Thus, this property is satisfied in some neighborhood of $x$ (as ${\mathcal{F}}$ and ${\mathcal{G}}$ are transversal). This proves the lemma for similar foliations.

In the general case, the ${\mathcal{F}}$-leafwise implication is still valid. Unfortunately, it is much more difficult to prove the ${\mathcal{G}}$-along implication, when the Riemannian metric is not invariant by the foliation $\mathcal G$. Let us suppose that $\bar{x}\in {\mathcal{G}}_x$. Denote by $\Phi_{x,\bar{x}}:E_x \rightarrow E_{\bar{x}}$ the holonomy map along the transversal foliation ${\mathcal{G}}$. Except for similar foliations, $\Phi_{x,\bar{x}}$ does not translate the Wiener measure $W_x$ on $E_x$ to a measure which is absolutely continuous with respect to the Wiener measure $W_{\bar{x}}$ on $E_{\bar{x}}$. This effectafterwards. The Markovian property implies, that the probability of the trajectory being distributed with respect to $\mu$ is arbitrary close to total probability of tending to ${\mathcal{M}}$. Thus, as the distance of decomposition can be chosen arbitrary small, almost every trajectory, tending to ${\mathcal{M}}$, is distributed with respect to $\mu$.

Denote by $Attr({\mathcal{M}})$ the basin of attraction of ${\mathcal{M}}$: this is the union of the leaves whose closure contains $\mathcal M$. Now, it is rather clear that the function $p_{{\mathcal{M}}}$ is positive exactly in the points of $Attr({\mathcal{M}})$.

\[c:unique\_neighborhood\] Any harmonic ergodic measure different from $\mu$ has a support disjoint from $Attr({\mathcal{M}})$.

A trajectory starting at $y\in Attr({\mathcal{M}})$ tends to ${\mathcal{M}}$ and is distributed with respect to $\mu$ with positive probability. If there exists another harmonic ergodic measure $\mu'$ with the support not disjoint from $Attr({\mathcal{M}})$, for $\mu'$-almost every


we will prove that if the Lyapunov of *any* harmonic measure is non negative, then there exists a transversely invariant measure.

We use an integral formula which expresses the Lyapunov exponent, and which has been founded in [@Candel; @Deroin]. Let $|\cdot|$ be a transverse conformal metric. In a foliation box we consider a transverse vector field $u$ which is invariant by the holonomy, and define $\varphi:=|u|$. Note that $\varphi$ is well-defined up to the multiplication by a leafwise constant function. Thus the function $f={\Delta}\log \varphi$ is a well-defined continuous function on $M$.

For any ergodic harmonic measure $\mu$ on $M$, $\lambda(\mu) = \int_M fd\mu$.\[l:lyapunov formula\]

For every $t\geq 0$, let $L_t:\Gamma \rightarrow {{\mathbb{R}}}$ be the functional defined by: $$L_t (\gamma) = \log |Dh_{\gamma|_{[0,t]}}|.$$ The family $\{ L_t\}_{t\geq 0}$ is a cocycle withfoliations of class $C^2$ without compact leaf, the following result completes the Main Theorem:

Let $\mathcal F$ be a codimension one foliation of class $C^2$ of a compact manifold, without compact leaves. Then if $\mathcal F$ has a totally invariant measure $\mu$, this measure is the unique harmonic measure. Then, for every point $x$, almost every Brownian path starting at $x$ is distributed with respect to $\mu$, and the diffusions of a continuous function $f:M\rightarrow {{\mathbb{R}}}$ tend uniformly to the constant function $\int f d\mu$.

By Sacksteder Theorem, the foliation $\mathcal F$ is minimal. We first prove that the measure $\mu$ is the unique totally invariant measure. By minimality of $\mathcal F$ and Haefliger’s argument [@Haefliger], there exists a transverse circle $C$ cutting every leaf. The transversely invariant measure (corresponding


$$\begin{gathered}
\dot{v}= (\frac{x}{y})_{y}' \cdot \kappa y +
\frac{1}{2}(\frac{x}{y})_{yy}'' \cdot 2y^2 + (\frac{x}{y})_{x}'
\cdot \sqrt{2}y\, dW^1_t + (\frac{x}{y})_{y}' \cdot
\sqrt{2}y\, dW^2_t = \\
= -\kappa y \frac{x}{y^2} + \frac{2x}{y^3} y^2 + \sqrt{2} (dW^1_t +
\frac{x}{y} dW^2_t) = (2-\kappa) v + \sqrt{2}(dW^1_t + v dW^2_t).\end{gathered}$$ This implies that $v$ satisfies a stochastic differential equation $$\dot{v}=(2-\kappa) v + \sqrt{2(1+v^2)} dW_t.$$ Let us now make another change of variable: we denote $\xi=f(v)=\log(v+\sqrt{1+v^2})$. Then $\xi$ satisfies the following stochastic differential equation: $$\begin{gathered}
\dot{\xi}=f'(\xi) (2-\kappa) v + \frac{1}{2}f''(\xi)
(\sqrt{2(1+v^2)})^2 + f'(\xi) \sqrt{2(1+v^2)} dW_t =
\\
= \frac{1}{\sqrt{1+v^2}} (2-\kappa) v - \frac{1}{4}
\frac{2v}{\sqrt{1+v^2}^3} (2(1+v^2)) + \sqrt{2}\,dW_t =
\\
= \frac{v}{\sqrt{1+v^2}} (1-\kappa) + \sqrt{2}\, dW_t.\end{gathered}$$ For $\kappa>1$ we notice that the Brownian component of this stochastic differential equation is constant, and the drift is towards $0$ with the velocity separated from zero for large $v$. Thus, there exists a probabilityexactly the support of $\mu$. It is clear that one can suppose that $\mu$ does not charge any leaf.

Suppose that the foliation is oriented. Because the operator $\Delta_g$ is symmetric, the measure $\mu$ induces a transverse harmonic measure which is $\Delta_g$-harmonic. From every point $x$ of $M$, the positive $\mathcal G$-orbit of $x$ intersects $\mathcal
M$ in a first time in a point $y$. Consider the function $f(x) =
\nu([x,y))$. This is a continuous function, because $\mu$ does not charge any leaf, and it is harmonic on every leaf. By Garnett lemma [@Garnett], this function has to be constant on $\mu$-almost every leaf, thus by continuity of $f$, $f$ is constant on the support of $\mu$. But on the minimal $\mathcal M$, $f$ vanishes, so that the restriction of $f$


$g'$ is defined using cut-off function.

Note, that the distance (in $C^{2d}$-topology, where $d$ is the dimension of the leaves of ${\mathcal{F}}$) between $g$ and $g'$ is at most $G_0 \theta e^{G_1 \cdot 2R},$ where $G_1$ is a constant, giving the maximum deviation of leaves of ${\mathcal{F}}$, and $G_0$ gives the maximum of derivative of $g$ along ${\mathcal{G}}$.

Also, we recall, that the heat kernel can be constructed explicitly as a series of convolutions. This procedure is described in the books of Candel [@Candel1] and Chavel [@Chavel]. In a few words, a function $L$, which “almost satisfies” the heat equation, is explicitly constructed, and then the real heat kernel is obtained as a sum of $L$ and a series of convolutions. These series are converging uniformly for every fixed moment of time $t$, and the dependencemost $\varepsilon_2/3$ part) and from $g'$ to $g|_{{\mathcal{F}}_{\bar{x}}}$ (at most $\varepsilon_2/3$ part due to common set of trajectories).

Now, let us estimate $\nu({\mathcal{F}}_x\setminus S)$, thus verifying the first condition. The points of this complementary can be of two types: either points of $B_R^{{\mathcal{F}}}$ with too small value of density (we note this set $X_1$), or with too big part of this density coming from trajectories, exiting the ball $B_R^{{\mathcal{F}}}(x)$ (we note this set $X_2$).

The first part is estimated as $$\begin{gathered}
\nu(X_1)= \int_{B_R^{{\mathcal{F}}}(x)} p(x,z;\delta) d{{\rm vol}}_g \le 3G_2 e^{2
G_1 R} \theta / \varepsilon_2 \cdot {{\rm vol}}_g(B_R^{{\mathcal{F}}}(x)) \le
\\
\le (3G_2 e^{2 G_1 R} \theta / \varepsilon_2) \cdot e^{G_4 R},\end{gathered}$$ where $G_4$ is the constant, bounding the growth of the leaves of ${\mathcal{F}}$.

The second part is estimated as follows: denote by $\rho(z)$ the part of the


$\theta$ sufficiently small $e^{-G_3 r(\theta)^2}< \frac{1}{2}
\sqrt{\theta}$. Thus, for all $\theta$ sufficiently small $$\Psi(\theta):=\Psi(r(\theta),\theta)<\sqrt{\theta}.$$ Now, denote $$S(\theta,x)=S(r(\theta),\Psi(\theta),\theta,x).$$ For this set, the conclusions of Proposition \[p:hkb\] is satisfied with $\varepsilon_1=\varepsilon_2<\sqrt{\theta}$. Let us choose a small transversal interval $J\subset I$, $J\ni x$, and consider the subset of $E_x$, defined as $$E_x'=\left\{ \gamma\in E_x | \, \forall n\ge 0 \quad x_{n+1}\in
S(\theta_n, x_n) \right\},$$ where $x_n=\gamma(n\delta)$ is the discretization sequence, corresponding to $\gamma$, and $\theta_n=|h_{\gamma|_{[0,n\delta]}}
(J)|$ is the sequence of the corresponding transverse distances (exponentially decreasing due to the nature of $E_x$).

\[l:ac\] For $\bar{x}\in J$, the images of the measure $W_x|_{E_x'}$ under $F$ and of the measure $W_{\bar{x}}|_{E_{\bar{x}}'}$ under $F\circ \Phi_{\bar{x},x}$ are absolutely continuous with respect to each other. The density can be made arbitrary close to 1 by choice of sufficiently small intervals $I$ and $J$. Moreover,charge any leaf, or equivalently, that measures $\nu_{\cdot}$ have no points of positive measure.

In this case, the measure $\mu$ induces on every leaf ${\mathcal{G}}_x$ a conditional measure $\nu_x$, which is harmonic in the sense of measure-valued functions (see Section \[ss:non-divergence\]). Let us take some $T>0$ and $C>1$ and for every path $\gamma$, starting at $x_0$, try to find a $\tau=\tau(\gamma)$, $T<\tau<2T$, as a minimal value $t_0$ in this interval possessing the following property: $$\label{eq:expansion}
\forall t\in[0,\tau] \quad
h'_{\gamma|_{[\tau,t]}}(\gamma(\tau))<Ce^{-\beta(\tau-t)}.$$ Here, we use $h_{\gamma|_{[\tau,t]}}$ as a short notation for $h_{\gamma|_{[t,\tau]}}^{-1}$ ($t<\tau$, and thus the first notation is not absolutely clear). Note, that as the holonomy is taken in the inverse sense, from the moment $\tau$ to $t<\tau$, one can expect that the derivative is will be small.

Note that the non-existence of such $\tau$ means,


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across and through the scenery.

Before we get a chance to kill the leader of the protests the demo ends in a shower of dramatic light and smoke, followed by the Second Son logo bounding onto the screen and all eventually fading to black. The fact that Sony and Sucker Punch are so intent on guarding the game’s more interesting moments is probably a good thing as it certainly rouses our interest, but it is undeniably frustrating to be left wanting in such a way.

The fact that we did feel like we wanted to play more after the fade out signifies the clear potential Second Son has. In terms of interaction, at least, the move towards faster and more streamlined action seems to be a positive change and shouldsmaller: 13 or k?
13
Suppose -9 = -2*v + z, -3*z + 1 = -6*v + 7*v. Suppose v*j + 12 = -0*j. Which is smaller: -4 or j?
-4
Let p = -1.2 - -0.2. Let q(c) = -2*c**2 + 33*c - 21. Let x be q(16). Is p at least as big as x?
True
Suppose 5 = 5*c + 3*y - 7*y, 2*c = -5*y - 31. Which is smaller: -12/7 or c?
c
Let p be 1/(((-6)/(-4))/((-9)/6)). Which is smaller: 9 or p?
p
Suppose r = u - 5, -4*r - 10 + 2 = 2*u. Let j be -3*u/(-3) + -1. Let b = 80 - 398/5. Is j > b?
True
Let r(x) = -x**2 - 6*x - 6. Let o be r(-5). Is o at least as big as -15/7?
True
Let n


Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice.
Galanin (GAL) impairs performance on cognitive tasks when administered centrally to rats. GAL transgenic (GAL-tg) mice overexpressing endogenous GAL show deficits on the probe trial of the Morris water maze spatial learning task, on the social transmission of food preference olfactory memory task, and on the trace cued fear conditioning emotional learning and memory task. Knockout mice deficient in the GAL-R1 receptor subtype were normal on most memory tasks, while showing a small deficit in trace cued fear conditioning, suggesting a selective role for the GAL-R1 in aversive memories, and implicating other GAL receptor subtypes in spatial learning and olfactory social memory. The growing body of rodent literature implicating excess GAL in cognitiveenergy not from a black hole but from its ambient electric field, while the black hole gives its charge to the scalar field.'
author:
- Takuya Katagiri
- Tomohiro Harada
title: 'Instabilities of charged anti-de Sitter black holes'
---

Introduction
============

The anti-de Sitter (AdS) spacetime is an exact solution of Einstein’s field equations with a negative cosmological constant. The AdS spacetime is maximally symmetric and geodesically complete, while it fails to be globally hyperbolic. This means that we cannot uniquely predict the complete time development from the initial data on a spacelike hypersurface. Ref. [@Wald:1988] gives a method to define the initial value problem for a massless scalar field in static and non-globally hyperbolic spacetimes in terms of the self-adjoint extension. Ref. [@Ishibashi:2004wx] discusses the same problem for scalar-vector-tensor linear perturbations in the AdS spacetime.

The


even in the presence of a black hole because that classification is based on the asymptotic behaviour of the field near the conformal infinity, although the critical values $\kappa_c$ and $\tilde{\kappa}_{c}$ could change because the regularity condition at the origin is replaced with the ingoing-wave condition at the black hole horizon. If both the scalar field and the black hole are charged, there can also appear electromagnetic superradiant instability. The electromagnetic superradiance in the asymptotically flat charged black hole will be briefly reviewed in Section \[RNBH\_superradiance\]. It should also be noted that the equation of motion for the charged scalar field cannot be written in the Schrödinger form as in Eq. (\[RADEQ\]). Hence, Theorem 1 does not apply for the charged scalar field.

We simultaneously demand the ingoing-wave condition $B_{\textrm{out}}=0$$\zeta/\pi\in[0.68042,0.68048]$ and $\textrm{Im}[\omega\ell]\in[-0.03,0.03]$. Comparing these figures with Figures \[rea\] and \[ef\], we can see that the symmetries $\omega\to -\omega$ and $\omega\to \omega^{*}$ for the AdS spacetime are broken for the neutral field in the AdS black hole spacetime. Here we point out that the symmetry for the real part $\omega\to -\omega^{*}$ remains. Thus, a black hole breaks the symmetry. Physically, the negative imaginary part of the QNF for $\zeta\leq\zeta_c$ comes from the dissipation of the scalar field into the black hole.

Figure \[wsf\] shows that $\zeta_0<\zeta_c$ is actually satisfied. It is also shown that $\zeta=\zeta_{b}$, which is defined as the bifurcation point at which the imaginary part splits into two different values, is slightly below $\zeta_0$. Hence, there are two QNFs which have one positive and one negative real


the other down along the axis as $\zeta$ increases. For $eQ>0$, the QNF with $\textrm{Re}[\tilde{\omega}]>0$ goes up, while that with $\textrm{Re}[\tilde{\omega}]<0$ goes down. For $eQ<0$, the result is opposite. This is a feature quite different from the neutral field. The mode which goes up eventually causes superradiant instability at $\zeta=\zeta_{c}$. We can see that the flow is consistent with the symmetry $\left(\tilde{\omega}, eQ\right)\to \left(-\tilde{\omega}^{*}, -eQ\right)$.

Physical interpretation \[sec:interpretation\]
==============================================

Electromagnetic superradiance\[RNBH\_superradiance\]
----------------------------------------------------

From Eq. (\[eomcs\]) and Eq. (\[anz\]), we obtain the radial equation, $$\label{rdeq}
\left[-\frac{d^2}{dx^2}+V(x)\right]u(x)=\left(\tilde{\omega}-\frac{eQ}{r}\right)^2u(x),$$ where $$V(x)=\frac{{\triangle}}{r^2}\left[\frac{1}{r}\frac{d}{dr}\left(\frac{{\triangle}}{r^2}\right)+\frac{1}{r^2}\left\{l(l+1)+\mu^2r^2\right\}\right].$$ We assume $\omega\in \mathbb{R}$. The effective potential of the charged scalar field in the charged black hole can be negative near the outer horizon depending upon the charge of the field. The region, where the effective potential is negative, is called the generalised ergoregion [@Denardo:1973pyo].

Here, we firstresult: $$\begin{aligned}
 J_{(m)a}n^{a}|_{{\cal H}_{+}}&=&2\left|\tilde{\omega}-\frac{eQ}{r_{+}}\right|^{2}|\Psi|^{2},
\label{eq:Jn} \\
 J_{(em)a}n^{a}|_{{\cal H}_{+}}&=&0, \\
 j_{(e)a}n^{a}|_{{\cal H}_{+}}&=&2e \left(\tilde{\omega}_{R}-\frac{eQ}{r_{+}}\right)|\Psi|^{2}.
\label{eq:jn}\end{aligned}$$

Eq. (\[eq:Jn\]) implies that no energy can be extracted from the black hole irrespective of the value of $\tilde{\omega}$.

Assuming a quasistatic change, we can also find $$\Delta Q=\frac{e\left(\tilde{\omega}_{R}-\frac{eQ}{r_{+}}\right)}{\left|\tilde{\omega}-\frac{eQ}{r_{+}}\right|^{2}}\Delta M$$ with $\Delta M\ge 0$.

We can see that if the superradiance condition is satisfied in terms of $\tilde{\omega}_{R}$, we can conclude that $\Delta |Q| < 0$, that is, the black hole is discharged by the scalar field. This is because if $eQ>0$, Eqs. (\[scon\]) and (\[eq:jn\]) imply $e \Delta Q <0$, whereas if $eQ<0$, Eqs. (\[scon2\]) and (\[eq:jn\]) imply $e \Delta Q >0$.

Next we see the change in the area of the black hole due to the superradiance. In the near region, the metric can be well approximated by the Reissner-Nordström metric


= i + count;
            result.Add(n);
        }
    }

    return result;
}

On my dorky AMD x64 1800+ (dual core), for all primes below 1 billion in 34546.875ms.  Problem seems to be storing more in the bit array.  Trying to crank more than ~2billion is more than the bitarray wants to store.  Any ideas on how to get around that?

A:

I would "swap" parts of the array out to disk. By that, I mean, divide your bit array into half-billion bit chunks and store them on disk.
The have only a few chunks in memory at any one time. With C# (or any other OO language), itimpressive. If you wish to read it in it’s entirety check it out over here (http://www.smithhousenashville.com/history). There a few key points that really stick out to me about the The Standard at the Smith House. It was originally built in the 1840s it’s the only remaining townhouse in downtown Nashville. Sadly, this is becoming more and more common with all the construction going on around town, we’re starting to lose some of our heritage. Thankfully Joshua and his crew are doing their part in keeping this alive.

Joshua began giving me a tour which started in a large room with fireplace. Turns out Andrew Jackson was married in front of that fireplace. Yeah, former President of the United States Andrew Jackson, the guy on the $20 bill. He’s kind


raises the risk for heart disease and other health problems, such as diabetes and stroke. The analysis, Avocado Consumption by Adults is Associated with Better Nutrient Intake, Diet Intake, Diet Quality, and Some Measures of Adiposity:National Health and Nutrition Examination Survey, 2001 -2012 , was published in the journal Internal Medicine Review.

Avocado consumers were 33% less likely to be overweight or obese and 32% less likely to have an elevated waist circumference compared to non-consumers.

Incidence of metabolic syndrome was significantly reduced for avocado consumers.

The findings are based on avocado consumption and its association with nutrient and food group intake, diet quality, and health biomarkers assessed using a nationally representative sample of 29,684 adults (ages 19 years and older) participating in the 2001-2012 NHANES. Fresh avocado intake averaged ayour bones healthy and strong. Whether dairy isn’t an option for you, or if you’re just looking for some variety, broccoli rabe will give you a tasty calcium boost that you need.

Protect your eye health. Carrots tend to get most of the credit when talking about eye health, but broccoli rabe and other leafy greens contain lutein, which help block certain light rays from damaging your eyes.

Work in some protein! Now, it’s no surprise that leafy greens aren’t as protein-rich as meat, tofu, or other meat substitutes, but with more than 1 gram per cup of broccoli rabe, you can give yourself a little protein boost from an unexpected source.

DO choose nutrient dense dark, leafy greens such as broccoli rabe over less nutritious options

DON’T drench or fry your


keeps the doctor away.” A recent release by U.S. Apple Association (USApple), shows that eating apples can help fight the factors that contribute to heart disease, the leading cause of death globally.

The release provides evidence from research that shows the benefits of eating apples:

An Ohio State University study recently found that eating an apple a day for four weeks lowered blood levels of oxidized LDL the bad cholesterol by 40%.

A University of Oxford (UK) study found that eating an apple once a day may be just as beneficial as daily statin use when it comes to preventing vascular deaths in individuals over 50.

A University of Florida study found eating two apples a day reduced LDL by 23%.

U.S. researcher’s report that for every 10 grams of fiber consumed perlead to a significant impact on women\'s health and quality of life. Also, PCOS patients have an increased risk of cardiovascular disease, 2.7 times the risk of endometrial cancer, and are associated with problems, such as pregnancy complications and emotional distress.^\[[@R4]--[@R7]\]^ Therefore, PCOS is associated with a number of severe reproductive and metabolic abnormalities, leading to a large social burden, thus early diagnosis and treatment are necessary.

Due to the complex pathology and causes of PCOS, clinicians and researchers are not fully aware of the underlying disease.^\[[@R8]\]^ Therefore, comprehensive treatments for PCOS have not been proposed yet, and since there are currently no drugs approved as PCOS indications, actual clinical treatment is dependent on individual patient\'s symptoms.^\[[@R9]\]^ Oral contraceptive pills (OCPs) are widely used to reduce menstrual irregularity and


hyperandrogenism, and clomiphene citrate is used to induce ovulation in infertile patients.^\[[@R9]\]^ However, OCPs have been reported to increase the risk of venous thromboembolism, and there is a continuing debate over the lack of meaningful data supporting the effects of glucose metabolism.^\[[@R10],[@R11]\]^ On the other hand, some experts have raised the issue that the long-term risk-benefit ratio is not clear, since the study period of many PCOS target chemical drugs is only a short 1 year or so.^\[[@R12]\]^ Because of these limitations of existing treatments, discussions about novel approach to PCOS patients are being actively made, and the interest in Traditional East Asian herbal medicine is increasing as one of these significant options.

In traditional East Asian Medicine, including traditional Korean Medicine, medicinal herb-based herbal formulas have been administered.composed of several keywords including various symptoms of PCOS and various dosage forms of CDD, and they are as follows: polycystic ovarian syndrome, PCOS, amenorrhea, oligomenorrhea, hyperandrogenism, polycystic ovaries, ovulatory dysfunction, anovulation, hirsutism, infertility, and cangfudaotan decoction/granule/formula/tablet/pill/capsule. Table [1](#T1){ref-type="table"} shows that the search strategy for PubMed and modified search strategies will be applied to other databases.

######

Search strategy for PubMed.

![](medi-98-e17321-g001)

2.4. Study screening
--------------------

Two researchers will independently assess all relevant studies and select eligible articles that meet inclusion criteria by reviewing the titles and abstracts. The language will be limited to English, Korean or Chinese. The full-texts of articles will be examined for further evaluation. In case of discrepancy between review authors, an agreement will be made by the discussion with the corresponding author (HG). The procedure of study selection


more than 10 articles for the meta-analysis, we will generate funnel plots to assess publication bias.

### 2.5.9. Grading the quality of evidence

The GRADE system will be used for evaluating the quality of evidence in systematic reviews. The following 5 items will be assessed: risk of bias, consistency, directness, precision, publication bias, and additional points. The result of assessments will be graded into 4 levels: high, moderate, low or very low.

3. Discussion
=============

PCOS is an endocrine disorder that can interfere with the quality of life in women and can be a high risk factor for type 2 diabetes mellitus and cardiovascular disease in overweight women.^\[[@R20]--[@R22]\]^

Various western medication treatments are used for PCOS therapy, but their use is controversial due to their side effects. For examples, common side effects of OCPs fileHandle = open(filename, "w")
    fileHandle.flush()
    fileHandle.close()

  return

def Mkdir(path, parents = False):
  """
  Create a directory at the specified path. Make all parents if parents is True.
  """

  if parents:
    parentPath = ""
    for dir in path.split(os.path.sep):
      parentPath = os.path.join(parentPath, dir)
      Mkdir(parentPath, parents = False)
  else:
    if not FileExists(path) or not Isdir(path):
      os.mkdir(path)

  return

def Cp(donor, target):
  """
  Copy a file
  """

  shutil.copy(donor, target)

  return

def Move(donor, target):
  """
  Move a


21 Football Championship: 3
 1989, 1990, 1996
 Meath Under 16 Football Championship: 3
 1989, 1992, 2019
 Meath Under 14 Football Championship: 3
 1987, 1990, 2018
 Meath Under 12 Football Championship: 2
 1985, 1988

References
https://www.facebook.com/gaeilcolmcille.gaa
https://twitter.com/GaeilColmcille
https://web.archive.org/web/20100723140322/http://meath.gaa.ie/fixtures-results.htm
http://gaeilcolmcille.ie

Category:Gaelic Athletic Association clubs in County MeathContrarian voices such as _China News Analysis_ (1961, as cited in Leys 1990), the Asian People's Anti-Communist League (1962) and Chu (1964) were ignored or not heard.
5

**Famine Is Not the Problem—For Now**

In all ages of the world except the present, want of food has caused wholesale destruction of the people.... But gradually the effects of increased wealth and improved means of communication are making themselves felt nearly all over the world; the severity of famines is mitigated even in such a country as India; and they are unknown in Europe and in the New World.

Alfred Marshall1

**The Changing Nature of Famine**

Controversies about the nature and existence of famines are not new, and they are ongoing. Some are about issues of guilt; some about famine denial; some about the very


end 10(-11) g/L group, beta end 10(-14) g/L group, and beta end 10(-11) g/L + Nal group). Another MNCs were cultured without addition of beta end (beta end 0 g/L group). Then the MNCs were collected. RT-PCR was used to detect the expressions of interleukin (IL)-1beta, IL-2, IL-8 and iNOS mRNA in the MNCs. The serum beta-end level of the patients with cerebral hemorrhage at the acute stage was 129 +/- 82 ng/L, significantly lower than that of the normal controls (321 +/- 62 ng/L, P<0.01) and that of the patients with cerebral thrombosis (264 +/- 163 ng/L, P<0.05), but not significantly different from that of the patients with cerebral hemorrhage in the convalescent stage (160 +/- 72 ng/L, P>0.05). The expression of IL-1beta and the expression of*
 * The Original Code is Copyright (C) 2001-2002 by NaN Holding BV.
 * All rights reserved.
 */

/** \file
 * \ingroup bli
 */

#include <stdio.h>
#include <stdlib.h>
#include <string.h>

#include "MEM_guardedalloc.h"

#include "BLI_dynlib.h"

struct DynamicLibrary {
  void *handle;
};

#ifdef WIN32
#  ifndef _WIN32_WINNT
#    define _WIN32_WINNT 0x501 /* Windows XP or newer */
#  endif
#  define WIN32_LEAN_AND_MEAN
#  include <windows.h>
#  include "utf_winfunc.h"
#  include "utfconv.h"

DynamicLibrary *BLI_dynlib_open(const char *name)
{
  DynamicLibrary *lib;
  void *handle;

  UTF16_ENCODE(name);
  handle = LoadLibraryW(name_16);
  UTF16_UN_ENCODE(name);

  if (!handle) {
    return NULL;
  }

  lib = MEM_callocN(sizeof(*lib), "Dynamic Library");
  lib->handle = handle;

  return lib;
}

void *BLI_dynlib_find_symbol(DynamicLibrary *lib, const char *symname)
{
  return GetProcAddress(lib->handle, symname);
}

char *BLI_dynlib_get_error_as_string(DynamicLibrary *lib)
{
  int err;

  /* if lib is NULL reset the last error


so many variables ( some dynamic like the wind ) you might be better at starting with a rough guess, and having 4 buttons - " up a bit " ,"down a bit " , " left a bit" and " right a bit " , just like real mortars have been aimed for years :-)

external ballistics is completelly different topic... whether or not the projectile hits the intended target depends on more variables but first I have to deal with the end effector here so to speak - ie. what calculations are needed to translate my request -> azimuth 120.5deg; elevation 42deg into numer of steps for the two step motors

Yes, I was suggesting that even working out the angle of the tube, compared to motor steps,by dist) to integers (number of steps) I would have to do it anyway

Quote

So, you're trying to do this by pulling on your barrel with wires, at some distance away from the pivots? Oooph

Yeah that's pretty much the idea - say what you want but since it would require only TWO motors and very limited hardware to cover 360 deg arc and wide range of elevations - so I guess it's kind of cool idea. If this approach prove to be inaccurate then I might as well switch to theaded rods

Quote

the angles you're giving as input are themselves only approximate solutions to the real problem of hitting a specified landing spot

external ballistics IS very complex - I can assure you I am aware of it and I know


the longitudinal direction thereof and movable electrode fingers 12bR and 12bL mounted to the both sides of each beam 12aR, 12aL and arrayed apart from each other in parallel. Fixed interdigitated electrodes 21R, 21L, 22R and 22L are provided so as to sandwich the movable interdigitated electrodes 12R and 12L in the longitudinal direction of the movable rod 11. The fixed interdigitated electrodes 21R and 22R have fixed electrode fingers 21bR and 22bR arrayed in parallel from each other in a direction orthogonal to the longitudinal direction of the movable rod 11 and anchored to the substrate 20. Each one end of the fixed electrode fingers 21bR and 22bR is disposed so as to interdigitate with the movable electrode finger 12bR from each other. The same applies tothe mirror 4 is stored within the slot 25. When voltage is applied between the terminals 15R and 15L (and/or between the terminals 16R and 16L) and the terminals 13R and 13L in the second stable state, the movable rod 11 returns to the first stable state shown in FIG. 8. The movable rod 11, the hinges 23R, 23L, 24R and 24L, the movable interdigitated electrodes 12R and 12L and the fixed interdigitated electrodes 21R, 21L, 22R and 22L compose the actuator 100 together with the substrate 20.
By the way, although the electrostatic actuator with the interdigitated electrode structure of the optical switch described above has been already put into practical use, there has been a case when the movable rod 11 displaces in the direction crossing with


1--2 million estimated new cases every year [@pntd.0001805-WHOwebsite3]. Widely used medications are still based on *i.v.* application of antimony compounds like stilbogluconate, resulting in severe side effects. More modern, but also more expensive medications are liposomal amphotericin B, miltefosine, and paromomycin [@pntd.0001805-WHOwebsite4].

Thus new affordable and effective therapies are urgently needed to combat these disastrous diseases. Registration requirements for agrochemicals are in some aspects even more stringent than for pharmaceuticals, as side effects that are tolerated for drugs against many life threatening diseases, are not acceptable for agrochemicals that potentially could enter the food chain [@pntd.0001805-Swanton1], [@pntd.0001805-Friedrich1], [@pntd.0001805-Nosten1]. As a consequence, all commercialized agrochemicals must go through broad toxicological profiles including e.g. chronic and reprotoxicological studies in different mammalian species, covering at least part of the preclinical studies requiredin hypoxanthine-free culture medium and titrated in duplicates over a 64-fold range in 96-well plates. Infected erythrocytes (1.25% final hematocrit and 0.3% final parasitemia) were added into the wells. After 48 h incubation, 0.5 µCi of \[^3^H\]hypoxanthine per well was added and the plates were incubated for an additional 24 h. Parasites were harvested onto glass-fiber filters, and radioactivity was counted using a *Betaplate* liquid scintillation counter (*Wallac*, Zurich). The results were recorded and expressed as a percentage of the untreated controls. Fifty percent inhibitory concentrations (IC~50~) were estimated by linear interpolation. Assays were run in duplicate and at least repeated once. Artesunate and chloroquine were used as positive controls.

### *Trypanosoma brucei rhodesiense (Tb)* {#s2b2}

*Trypanosoma brucei rhodesiense* strain STIB900 was isolated in 1982 from a human patient in


Tanzania and after several mouse passages cloned and adapted to axenic culture conditions [@pntd.0001805-Baltz1] Minimum Essential Medium (50 µL) supplemented with 25 mM HEPES, 1 g L^−1^ additional glucose, 1% MEM non-essential amino acids (100×), 0.2 mM 2-mercaptoethanol, 1 mM Na-pyruvate and 15% heat inactivated horse serum was added to each well of a 96-well microtiter plate. Serial drug dilutions of eleven 3-fold dilution steps covering a range from 100 to 0.002 µg mL^−1^ were prepared. Then 4×10^3^ bloodstream forms of *T. b. rhodesiense* STIB 900 in 50 µL was added to each well and the plate incubated at 37°C under a 5% CO~2~ atmosphere for 70 h. 10 µL resazurin solution (resazurin, 12.5 mg in 100 ml double-distilled water) was then added to each well and incubationpyraoxystrobin (LD~50~ not available), resulting in IC~50~ values of 84, 148, 305 and 859 nM activity, respectively.

The pre-emergence herbicides from the dinitroaniline-type including prodiamine (LD~50~ rat p.o. \>5000 mg/kg), dinitramine (LD~50~ rat p.o. 3000 mg/kg), and fluchloralin (LD~50~ rat p.o. 1550 mg/kg), showed values of 118, 253 and 816 nM activity, respectively. Their mode of action is the inhibition of mitosis. Other herbicidal dinitroanilines have been shown before to have antiplasmodial activity, but on a significantly weaker level [@pntd.0001805-Fennell1].

The plant growth regulator tetcyclacis (LD~50~ rat p.o. 261 mg/kg) inhibits P450 enzymes [@pntd.0001805-Rademacher1] and exhibits an IC~50~ value of 194 nM.

Fenchlorazol-ethyl (LD~50~ rat p.o. \>5000 mg/kg), an herbicide safener used in cereals, showed 223 nM activity. Furthermore, the corresponding acid, which is potentially the first metabolite of fenchlorazol-ethyl, showed


against some of the most important pathogens of infectious tropical diseases. Interestingly as anticipated, several of the oomyceticides (strobilurins against *P. falciparum*, zoxamide against *T. b. rhodesiense* and *L. donovani*) were active against these protozoans, but also other agrochemicals (e.g. hydramethylnon against *P. falciparum*; azoles like iproconazole against *T. cruzi*) showed very interesting activities. Exemplified by one of the major commercial agrochemicals, the fungicide azoxystrobin, as well as for the insecticide hydramethylnone, the reduction of parasitemia, and significant life extension for *P. berghei* infected mice was achieved. For zoxamide, an effect against *T. brucei* in the mouse model was also demonstrated. This successful *in vitro-- in vivo* transfer without galenic optimization could not be taken for granted, as these agrochemicals have not been optimized for mammalian pharmacokinetics.

There isbetween India and Pakistan in the last 50 years. Another one appeared ominously near.

After four days trekking, I arrived at my first destination, the tiny village of Photaskar. It's tightly grouped houses were perched on the very edge of the Yapola River's deep gorge that carries glacial melt east to the mighty Indus River. Trying to coax grain out of the ground at 15,000 feet, were a string of orbital terraced fields that ringed the top of both sides of the gorge. Behind the village a massive fan of ochre rock, swirled with mocha striations, soared up a thousand feet. This huge granite face was mirrored by an even bigger twin monolith directly across the river canyon. Both were dwarfed by the backdrop of a snow laced mountain


our individual or personal sense of the kind of life worth our living. If beauty warrants love, and our love is personal in this sense, then how can beauty also be disinterested? Similarly, consider Kant's influential claim that judgments of beauty contain a claim to universal agreement. Again, what we are capable of loving seems to be dramatically variable across subjects, and within subjects across time. If beauty is the object of love, then it is difficult to see how judgments of beauty could contain a claim to universal agreement. Notably, philosophers who tend to favor the view that beauty is the object of love also tend to explicitly distance themselves from these elements of Kantian aesthetics. (However, Kant does acknowledge a connection between beauty and love. Inperson as, very roughly, unfairly possessing that which one desires but lacks. So, we might ask, what is the associated representation, if any, of the emotion involved in beauty? Answering this question might give us a better grip on why one might count this emotion as a species of love. And here we might draw on the increasingly sophisticated developments in the theory of interpersonal love. BIBLIOGRAPHY Brentano, Franz. The Origin of our Knowledge of Right and Wrong. Translated by Roderick Chisholm and Elizabeth Schneewind, London: Routledge, 1969. See also Chisholm's book Brentano and Intrinsic Value, Cambridge University Press, 1986. Burke, Edmund. A Philosophical Enquiry into the Origin of our Ideas of the Sublime and the 8 Beautiful, edited by Adam Phillips. Oxford University Press, 1990. Carson, Anne.


by Kalabakas. As shown in FIG. 1A, device 100 comprises a vessel 110 adapted to contain a reservoir of liquid 112 and a dispensing apparatus 120 adapted to fit within an opening 114 of the vessel 110. Apparatus 120 includes a lower well 130, an upper well 140, and a tube member 150 descending into vessel 110, such that, as shown in FIG. 1B, a quantity of liquid 122 may be transferred from vessel 110, through tube member 150, out at least one opening 152 in tube member 150, and into lower well 130 and upper well 140. Opening 152 prevents the level of liquid 122 from rising higher in upper well 140 than the level of opening 152.
Referring to FIG. 1C, once liquid 122 is so dispensed,it may be poured from device 100 by angling device 100 at an angle α. As can be seen, however, where the quantity of liquid 122 is relatively large, angle α (the “pouring angle”) may be too shallow to allow liquid 122 to be poured from device 100 without risk of spilling. Typically, angle α is between about 45 degrees and about 55 degrees.
To this extent, a need exists for a dispensing apparatus and device that does not suffer from the defects of known apparatuses and devices.


Network devices, such as routers, receive data on physical media, such as optical fiber, analyze the data to determine its destination, and output the data on physical media in accordance with the destination. Routers were initially designed using a general purpose processor executing large software programs. As line rates and traffic volume increased, however, general purpose processors could not scale to meet the new demands. For example, as new functions, such as accounting and policing functionality, were added to the software, these routers suffered performance degradation. In some instances, the routers failed to handle traffic at line rate when the new functionality was added.
To meet the new demands, purpose-built routers were designed. Purpose-built routers are designed and built with components optimized for routing. These routers not only handleamong others, tried to pull the singer back onto the stage, Cobain popped the bouncer in the head with his guitar.

Van Blarcum then retaliated with a right cross to Cobain's jaw. After that, all hell broke loose. Van Blarcum tried to explain what happened to whomever would listen as two band members scattered off stage. Almost immediately, the crowd started chanting, "Bullshit." Watching the now-available-on-Youtube videos from the night (shot by Brad Featherstone from stage left), it's clear: The evening looked ripe for a riot.

"I vividly remember us making the decision to throw on 'Smells Like Teen Spirit' when we were trying to get the band back out after the fight," says Alex Luke, former host of "The Adventure Club" on KDGE-FM 102.1 The Edge. "It was a


theology and psychology, has provided helpful directions in dealing with one of the most serious pastoral problems facing the Church today. A valuable resource for discerning the credibility of these phenomena of miraculous visions and happenings." — Bishop John Sheets, S.J., Diocese of Ft. Wayne-South Bend  }
                }
            } else
            {
                Console.WriteLine("Database already saved on device");
            }

        }
    }
}

and calling the Open() method from the Android project's OnCreate() method
MainActivity.cs
protected override async void OnCreate(Bundle savedInstanceState)
        {
            TabLayoutResource = Resource.Layout.Tabbar;


U.S. Pat. No. 4,637,144 discloses an apparatus for checking the diameter of crankpins orbiting about a geometrical axis, in the course of the machining in a grinding machine. The apparatus is supported by a support fixed to the worktable of the grinding machine, or by a support affixed to the bed of the grinding machine, or by a longitudinal slide arranged on the worktable.
The apparatus comprises a reference device, Vee-shaped or of another type, for cooperating with the crankpin to be checked, a measuring head fixed to the reference device and provided with two movable arms carrying feelers for contacting diametrically opposite points of the crankpin, a cylinder and piston device, and a coupling device between the cylinder and the support of the apparatus. The reference device isonto a stable powerline support tower.
Another object of the present invention is to provide a novel and improved lineman""s ladder which is lightweight and which can be lowered from a helicopter and easily positioned between a tower cross arm and energized conductors by a single lineman.
Yet another object of the present invention is to provide a novel and improved helicopter lineman""s ladder which will deliver a lineman from a tower to energized powerlines and insure that the lineman is a safe distance from the tower before the lineman bonds to an energized powerline.
A still further object of the present invention is to provide a novel and improved helicopter lineman""s ladder which operates to prevent a lineman who has bonded to an energized powerline from inadvertently moving dangerously close


vibration 40 min 15--30%) were decreased significantly when compared with untreated group (\>50%). The H&E staining results showed consistent trend with oil red O staining. All the histological results indicated that both the number and size of lipid droplets were remarkably decreased after vibration treatment.Figure 3(**A**) Oil Red O staining. (**B**) H&E staining.**Notes:** Several slices liver cutting from different region of the whole liver were embedded in OCT and paraffin. The frozen samples were cut in 10μm slice then staining with Oil red O. The paraffin samples were cut in 6μm then with H&E. Taking pictures with 100 folds.

Muscle Strength {#S0004-S2004}
---------------

Muscle strength was evaluated by two ways: grip strength meter and Rotarod apparatus. The results of grip strength meter indicated that vibration treatment significantly increased muscle strength comparingVai, Professor Kwok-Sui Leung, Professor Wing-Hoi Cheung, Professor Kwok-Pui Fung and Professor Guozhen Cui. This study was supported by The Science and Technology Development Fund, Macau S.A.R (FDCT0058/2019/A1) (Reference no. 061-2017-AIR) and the Multi-year Research Grant from University of Macau (Reference no. MYRG2019-00105-ICMS and MYRG2015-00182-ICMS-QRCM).

Abbreviations {#S0007}
=============

AMPK, AMP-activated protein kinase; ANOVA, analysis of variance; Ct, threshold cycle; EMG, electromyography; FASN, fatty acid synthase coding gene; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; LMHFV, low-magnitude high-frequency vibration; Nrf1, nuclear respiratory factor 1; NAFLD, nonalcoholic fatty liver diseases; OCT, optimal cutting temperature compound; p38, p38 mitogen-activated protein kinases; PGC-1α, peroxisome proliferator-activated receptor gamma co-activator 1-alpha; qPCR, quantitative polymerase chain reaction; RT-PCR, real-time polymerase chain reaction; SD, standard deviation; Tfam, transcription factor A.

Disclosure {#S0008}
==========

The authors report no conflicts of interest in this work.


been criticized recently, and he picks on her IQ. Then he picks on Senator Warren and her race.”… “On the … point on language, why do you think he keeps calling her ‘Pocahontas?’” Baldwin asked incredulously. “It is not just sexist, it is racist!”

I don’t automatically dislike Brooke Baldwin’s commentary. She did call out Samantha Bee a couple months ago for her crude and obnoxious attack on Ivanka Trump. And a few weeks ago she pressed Sen. Tammy Baldwin about whether or not she felt any outrage over childhood detentions when Obama was president. I’m not suggesting Baldwin plays things down the middle but I have to give her credit for occasionally suggesting that the left should be held to some standards too.

That said, Baldwin’s commentary here isER doctor who treated Kennedy shunned fame

Sue Carrico, the wife of Dr. Charles “Jim” Carrico, the first doctor to treat President John F. Kennedy upon his arrival at Parkland Memorial Hospital in Dallas, reads a letter she penned to Jacqueline Kennedy offering her condolences on the evening of Nov. 22, 1963. She never mailed the card and still has it.

He didn’t like discussing the day in 1963 when President John F. Kennedy was wheeled into the emergency room at Dallas’ Parkland Memorial Hospital.

Dr. Charles “Jim” Carrico, who grew up in Denton, was 28 and in his second year as a surgical resident at Parkland the day the president was brought into the hospital at 12:35 p.m. with gunshot wounds to the head and neck.

Carrico was the first doctor


[He never] would have said that.”

Bill Carrico, Jim’s brother, an educator who went on to become the athletic director for the Denton school district and who still lives in Denton, said he was teaching drafting when it was announced on the radio that the president had been shot. He said his brother was 16 months older and they were very close.

Bill Carrico said he knew when he heard the news that the event would impact his brother.

“I felt it. I can’t explain it,” he said. “It’s just sometimes twins, brothers and sisters feel things. I was just tight as a drum when the radio came on and said that. I just knew he was involved. I felt it.”

Dr. Carrico’s wife, Sue, was at their Irving home watching Asthere ... whether you could be saved or not,” she said. “He was such a special person. He was an incredible doctor.”

Dr. Carrico, who was a graduate of Denton High School and what is now the University of North Texas, left Parkland after his residency in 1967. He joined the U.S. Navy and served two years, then returned to Parkland in 1969 and worked there until 1974. In 1974, he and his family moved to Washington state, where he subsequently became chief of surgery at Harborview Medical Center in Seattle and where he helped start a Level 1 Trauma Center.

He was chairman of the surgery department at the University of Washington School of Medicine, and in 1990 he joined the staff at the University of Texas Southwestern Medical


structures.

Plans aren’t the only part of the project that’s been faulty, though.

The one speed hump that has been installed is 4 inches high and, residents maintain, forces traffic to slow down to 20 to 25 miles per hour. It was supposed to be 2 inches high, letting traffic stay at the posted 35 miles per hour, and the town has reached out to the contractor to fix the problem.

Others say they’re fine with the higher speed humps.

“I don’t think slowing down 10 miles an hour or 15 miles an hour to keep a child or a pet or an adult safe is too much to ask,” said Jeff Gaskill, an Olde Towne resident.

The board will also hold a special meeting at 7 p.m. May 6 at town hallto discuss the purchase of a new town hall facility. Jim Eldridge, the town’s attorney, said the contracts for the Waterford condominium are nearly completed, but there is still some work to be done on the paperwork for some land on Poole Road.

At that meeting, the board will also discuss how to handle the speed hump dilemma, with commissioners expressing interest in finding a way to pay for all eight humps.