(Fig[5E](#fig05){ref-type="fig"} and [F](#fig05){ref-type="fig"}, left). Of importance, cyclin D1b expression was required for growth in serum independent conditions, wherein loss of cyclin D1b resulted in a substantial reduction in BrdU incorporation as compared to control (Fig[5F](#fig05){ref-type="fig"}). These findings strikingly reveal an independent capacity of endogenous cyclin D1b to confer serum independence, consistent with capacity of cyclin D1b to drive tumor formation *in vivo*.

Cyclin D1b expression promotes double-strand breaks and PARP1 activity
----------------------------------------------------------------------

Given the collective observations above that cyclin D1b elicits divergent effects on cellular transformation, and clinical observations that cyclin D1b expression is associated with therapeutic resistance, it was imperative to challenge the impact of therapeutic intervention and or genotoxic stress on cyclin D1b-driven tumor cells. Initially, the presence of DNA damage was assessed in *Ccnd1*^+/+^ and *Ccnd1*^*KI/KI*^ by quantifying intrinsic p-H2AXincrease in response to DNA damage) were assayed in *Ccnd1*^+/+^ and *Ccnd1*^*KI/KI*^ lines. As shown in Fig[6B](#fig06){ref-type="fig"}, auto-modified PARP-1 was low in *Ccnd1*^+/+^ control cells (lane 1), consistent with the low frequency of p-H2AX foci. Conversely, *Ccnd1*^*KI/KI*^ cells show dramatically heightened levels of PARP-1 activity (lane 2 and Supplementary Fig [S4B](#sd1){ref-type="supplementary-material"}), further demonstrating that cyclin D1b expression promotes intrinsic DNA damage. To compare intrinsic DNA damage signals to those induced in response to exogenous genomic insult, control and *Ccnd1*^*KI/KI*^ cells were treated with etoposide, known to induce double-strand breaks, and assayed for markers of DNA damage response. Cyclin D1a-expressing cells (*Ccnd1*^+/+^) showed low levels of PARP-1 activity, which were enhanced in the presence of genotoxic stress (Fig[6C](#fig06){ref-type="fig"} lanes 1, 2). Increased PARP-1 activity was not due to a


due to a defect in p53 signaling, the p53 target gene *Cdkn1a* (p21) was analyzed before and after etoposide treatment. As shown in Supplementary Fig [S5A](#sd1){ref-type="supplementary-material"}, an increase in *Cdkn1a* transcript is readily seen as early as three hours post-treatment in both *Ccnd1*^+/+^ and *Ccnd1*^*KI/KI*^ lines, which correlated with an increase of p21 protein (Supplementary Fig [S5B](#sd1){ref-type="supplementary-material"}), suggesting that *Ccnd1*^*KI/KI*^ cells maintain a functional p53 pathway. As a further control for specificity and relevance to human disease, the ability of cyclin D1b to promote intrinsic DNA damage signals was determined in human prostate cancer models (a tumor type known to shift from cyclin D1a to cyclin D1b (Comstock *et al*, [@b14])). Utilizing previously described isogenic models with or without cyclin D1b expression (Augello *et al*, [@b3]), it was observed thatcytometer was used to sort 10,000 single cells per biological replicate, and FlowJo software was utilized to gate for BrdU incorporation.

Assessment of mouse *in vivo* cardiac function via echocardiography
-------------------------------------------------------------------

The non-invasive technique of transthoracic echocardiography was conducted using a VisualSonics Vevo 770 high-resolution imaging system (Gao *et al*, [@b21]). Briefly, mice were anesthetized with 1.5% of isoflurane and two-dimensional echocardiographic views of the mid-ventricular short axis obtained at the level of the papillary muscle tips below the mitral valve. A minimum of 400 beats were recorded during each study and analyzed by an independent blinded observer. M-mode measurements of LV internal dimensions (LVID) are determined at the plane bisecting the papillary muscles according to the American Society of Echocardiography leading edge method on 5 heart beats chosen at random by each


  Benet testified that he had not, in fact, referred Aguirre to BT.   There was evidence that the referral may have come from another ABSA employee, Laura Machuca, who had received Giraldi's literature from Benet.   Further, the statement in the Benet Memo that Benet and his family had been Tier I clients (that is a client who had at least $10 million deposited with the bank) at Citibank for over 20 years was false.   The Benet family had an account with Citibank from 1983 that was worth $3 million, and was never designated a Tier I client during 1983-1987.   Because Giraldi handled Benet's Citibank account, he would have known that the information in his memo was false.

5
The signature cardfor conviction.

20
The government answers that the circumstantial evidence was sufficient for the jury to conclude that Giraldi did in fact know or was willfully blind to the source of Aguirre's funds.   This argument is supported by the evidence that Giraldi was specifically charged with investigating and knowing his client, was dishonest about the fact that he had not followed the prescribed procedures prior to taking the initial deposit, failed to properly "paper" various transactions during his relationship with Aguirre and took several actions to control the damage once the authorities began to investigate Aguirre's holdings.

21
After a careful review of the record, we have concluded that the evidence is sufficient to sustain Giraldi's conviction.

22
In addition to the falsehoods contained in the "Benet memo," Giraldi either personally made


object to the evidence or argument of which he now complains.  United States v. Christo, 614 F.2d 486, 492 (5th Cir.1980), forbids introducing evidence of civil banking statute violations solely for the purpose of proving criminal misapplication;  however, it does not hold that such evidence can never be introduced in a misapplication case.  United States v. Stefan, 784 F.2d 1093, 1098 (11th Cir.)  (cited with approval in United States v. Saks, 964 F.2d 1514, 1523 (5th Cir.1992)), cert. denied, 479 U.S. 1009, 107 S.Ct. 650, 93 L.Ed.2d 706 (1986).   References to banking regulations are appropriate in a criminal trial to explain the role of federal regulators, the rules by which the bank is governed, and the stakes in a bank fraud case.in the offense is the clearly erroneous standard.   See United States v. Watson, 988 F.2d 544, 550 (5th Cir.1993).

73
U.S.S.G. § 3B1.2 states that a defendant may receive a downward adjustment of four levels if he was a minimal participant in the criminal activity.   Giraldi's Presentence Report (PSR) did not recommend that he was entitled to these four points and Giraldi objected.   The district court awarded him the four points, saying, "It shouldn't be, but I will give it to him ... and I will tell you why it shouldn't be.   Simply because of the nature of his role, but I can see the scheme of things.   That is all right.   I will give you those four


after massive opposition demonstrations turned violent]. (…) It’s all highly suspicious, it’s the same script. Always! the guarimba, the aggressions, the victims. (…) Are we going to bite the bait again? What we need here is reason, orientation, and a sense of political struggle.” Furthermore, he warned that a non-electoral exit of Maduro could actually mean a takeover by the President of the National Assembly Diosdado Cabello, an idea that had much resonance in social media: “‘Maduro leave now’ [vete ya] could turn out be ‘Diosdado take over now’ [vente ya],” he said.

But Capriles has also attempted to not seem too complacent with the government. He has twice refused invitations by Maduro for dialogue, once in the context of the Consejo Federal de Gobierno and then to aSmith's evidence of derivative citizenship that they will be able to decide whether the government had successfully met its burden. See United States v. Gaudin, 515 U.S. 506, 509-10, 115 S.Ct. 2310, 132 L.Ed.2d 444 (1995) (Holding that the Due Process Clause and Sixth Amendment "require criminal convictions to rest upon a jury determination that the defendant is guilty of every element of the crime . . . beyond a reasonable doubt.").

32
The government's fear that juries will dole out United States passports to sympathetic defendants is without basis. Had Smith been permitted to present evidence of his U.S. citizenship that the jury found credible, the determination in his favor would not have had the effect of awarding him citizenship. The jury's finding would have determined only that the


231 F.3d at 1196. We held in that case that attempted illegal reentry is a specific intent crime. See id. at 1193. If it were not, "any proactive attempt to follow the legally sanctioned procedure for seeking permission to reapply to reenter the United States would actually be [an] illegal `attempt' to reenter." Id. at 1194 (quotations omitted). In other words, "the reason for requiring specific intent for attempt crimes is to resolve the uncertainty whether the defendant's purpose was to engage in criminal, rather than innocent, conduct." Id. at 1193.

37
Relying on Gracidas-Ulibarry, Smith argues that his defense to the specific intent element of the attempt offense is that at the time he applied for reentry, he reasonably believed that he was a U.S. citizen. He contends that17/118  (b) -0.2  (c) -6  (d) -4
b
Which is the closest to 5/6?  (a) 44  (b) -1  (c) -2  (d) 3
b
Which is the closest to -0.4?  (a) 12.1  (b) -6/13  (c) 15  (d) -5
b
Which is the closest to -0.3?  (a) 3  (b) 23.4  (c) -1
c
What is the closest to 1/2 in -1, 0.04, 1/4, 10?
1/4
Which is the nearest to -1?  (a) 8/3  (b) -0.3  (c) 33  (d) 1
b
What is the closest to -4 in -3/7, -0.4, -5, 8/35?
-5
Which is the closest to 121?  (a) -4  (b) -1/2  (c) -927  (d) 2/3
d
Which is the nearest to 2?  (a) -367  (b) 4  (c) 13
b
What is the


mutated in the catalytic domain (Y260A/F261A) \[[@B32]\]. Immunoprecipitation of IN and subsequent detection by Western blotting with an antibody specific to acetylated lysines revealed the highest acetylation signal in the sample corresponding to IN co-expressed with wild type GCN5 (Figure [2A](#F2){ref-type="fig"}, upper panel, lane 3). Conversely, expression of IN alone or together with catalytically inactive GCN5 resulted in a lower acetylation signal, likely derived from the activity of endogenous HATs (Figure [2A](#F2){ref-type="fig"}, upper panel, lanes 2 and 4). In this experiment, the total amounts of immunoprecipitated IN and the expression levels of wild type and mutant GCN5 were verified by Western blot analysis with anti-Flag and anti-HA antibodies, respectively (Figure [2A](#F2){ref-type="fig"}, middle and lower panels).

![**IN is acetylated by GCN5 *in vivo***. (A) Extracts from HEK 293T cells transfectedallowed detecting basal levels of IN acetylation by endogenous HATs following immunoprecipitation (Figure [2C](#F2){ref-type="fig"}, top-left panel, lane 1); additionally, high levels of IN acetylation were detected from cells overexpressing p300 (Figure [2C](#F2){ref-type="fig"}, top-left panel, lane 2). This result is consistent with our previous study showing that p300 mediates IN acetylation *in vivo*at positions 264, 266, and 273 \[[@B1]\]. Conversely, no signal, expressed either alone or together with p300 (Figure [2C](#F2){ref-type="fig"}, top-left panel, lanes 3 and 4), was detected with IN K264,266,273R, thus revealing the high specificity of the antibody. In this experiment, the amount of IN (wild type or mutated) immunoprecipitated in each sample was verified by Western blotting with an anti-Flag antibody (Figure [2C](#F2){ref-type="fig"}, bottom-left panel). The anti-acetylated IN antibody was also used for direct Western blot


mutated in the catalytic domain. After immunoprecipitation with an anti-Flag antibody, both wild type and mutant GCN5 were found to co-precipitate with IN, as demonstrated by Western blot analysis using an anti-HA antibody (Figure [3A](#F3){ref-type="fig"}, upper panel, lanes 3 and 4). Accordingly, in the reciprocal experiment, where immunoprecipitation was performed with an anti-HA antibody, IN was found to associate with GCN5 (both wild-type and mutant forms) (Figure [3B](#F3){ref-type="fig"}, upper panel, lanes 3 and 4). In both experiments, the total amounts of immunoprecipitated proteins and the expression levels of IN and GCN5 were verified by Western blotting (Figures [3A](#F3){ref-type="fig"} and [3B](#F3){ref-type="fig"}, middle and lower panels).

![**IN interacts with GCN5 both *in vitro*and *in vivo***. (A) Extracts from HEK 293T cells transfected with the indicated plasmids were immunoprecipitated using anti-Flag antibodyreverse transcription was not affected by the amino acidic substitutions. Integrated HIV-1 DNA was quantified at 48 hours post-infection by Alu-LTR nested PCR, showing a five-fold reduction in the number of proviruses for both mutant clones with respect to wild type (Figure [6C](#F6){ref-type="fig"}). These data indicated decreased integration efficiency upon mutation of IN lysines targeted by acetylation. Consistently, a three-fold increase in the amount of two-LTR circles was detected at 24 hours post-infection with both NL4.3-Luc-3mut and 4mut (Figure [6D](#F6){ref-type="fig"}), confirming a specific defect at the step of integration and no alterations during viral nuclear import.

![**Mutations at IN acetylation sites cause a replication defect at the step of integration**. (A) HEK 293T cells infected with NL4.3-Luc/IN WT, NL4.3-Luc/IN K264,266,273R, or NL4.3-Luc/IN K258,264,266,273R were analyzed for luciferase activity 48


kinetics of the wild type virus (Figure [6F](#F6){ref-type="fig"}). In conclusion, mutations introduced in the virus at IN acetylation sites targeted by both GCN5 and p300 (K264, K266, and K273), or additional mutation at lysine 258 specifically acetylated by GCN5 *in vitro*, determined similar decreases in viral integration and infectivity.

Discussion
==========

The results presented in this study reveal that GCN5 is a novel HAT which interacts with IN. GCN5 binding to the C-terminal domain of IN leads to the acetylation of IN at lysines 258, 264, 266 and 273, located within the same region required for the two proteins to interact. We have recently demonstrated that the carboxy terminus of IN is a substrate for another cellular HAT, p300, which acetylates IN lysines at positions 264, 266, and 273 \[[@B1]\], acomplexes with GCN5 and p300**. (A) Three-dimensional model of the IN/GCN5 complex. IN is represented in green and GCN5 in light grey. (B) Three-dimensional model of the IN/p300 complex. IN is represented in green and p300 in light grey. In (A) and (B), the three lysine residues in the C-terminal domain of IN that are acetylated by both GCN5 and p300 (Lys 264, Lys 266, and Lys 273) are shown in yellow. GCN5 and p300 are rendered as surfaces, while IN as a cartoon to highlight the C-terminal unfolded portion which inserts in the binding pockets of the two HATs.](1742-4690-7-18-7){#F7}

A comparative analysis, aimed at establishing the roles of the two HATs during the HIV-1 replication cycle, revealed that the mutant viruses expressing either IN K264,266,273R or IN K258,264,266,273R


Electronic Data Capture (REDCap) software \[[@CR14]\]. The database was approved by the institutional review board of the SFAR (IRB00010254-2015-010), which waived the need for signed informed consent of the participants, in accordance with the French legislation on noninterventional studies \[[@CR15]\]. The study was declared on [clinicaltrials.gov](http://clinicaltrials.gov) (NCT03506191). This manuscript was written in accordance with the STROBE statement for the reporting of observational studies in epidemiology.

Statistical analysis {#Sec12}
--------------------

The results are expressed as the number of patients (%) for categorical variables and mean (± standard deviation) or median \[IQR\] for continuous variables.

Prognostic factors associated with time to in-hospital death were studied using the Cox proportional hazard model. Time to in-hospital death was calculated from the diagnostic date of *S. maltophilia* to death. The follow-up was censored at discharge from thematched groups using a Cox proportional hazard model. The 95% confidence intervals of the estimated hazard ratio (empirical antimicrobial therapy yes vs no) were estimated using robust standard error \[[@CR18]\].

Significance was defined as *p* values \< 0.05. Statistical tests were two-sided. Statistical analyses were performed using R 3.5.0 (R Foundation for Statistical Computing, [http://www.R-project.org/](http://www.r-project.org/), Vienna, Austria).

Results {#Sec13}
=======

Population {#Sec14}
----------

Of the 102,316 patients admitted to the 25 ICUs within the study period, 282 (0.27%) with a *S. maltophilia* pneumonia were included (Fig. [1](#Fig1){ref-type="fig"}). Our population was predominantly male (69.9%), with an age of 65 \[56--74\] years, mostly admitted for medical reasons (59.2%) or emergent surgery (29.4%). Severity at admission was illustrated by SOFA score (8 \[5--11\]) and SAPSII (47 \[36--63\]). ICU and hospital lengths of stay were 32 \[19--58\] and 54 \[30--94\]


1.142\], *p* \< 0.0001) (Table [4](#Tab4){ref-type="table"}). The subsequent occurrence of a septic shock was significantly associated with an increased risk of death (HR = 3.070, 95%CI \[1.9; 5.0\], *p* \< 0.0001). Table 4Variables associated with the time to in-hospital deathVariablesUnivariate analysisMultivariate analysisHR \[95%CI\]*p* valueHR \[95%CI\]*p* valueAge1.025 \[1.012; 1.038\]0.00011.02 \[1.01; 1.04\]0.001SAPS II1.009 \[1.001; 1.018\]0.036Mechanical ventilation at diagnosis1.692 \[0.83; 3.46\]0.151VAP0.748 \[0.49; 1.14\]0.178Duration of MV before the diagnosis0.997 \[0.988; 1.006\]0.462SOFA score at diagnosis1.099 \[1.057; 1.142\]\< 0.00011.1 \[1.06; 1.15\]\< 0.001Bacteremia0.814 \[0.41; 1.60\]0.551Monomicrobial pneumonia1.368 \[0.98; 1.91\]0.066Co-infection with *Pseudomonas aeruginosa*0.843 \[0.53; 1.33\]0.464Time elapsed between pulmonary sample and effective antimicrobial therapy0.99 \[0.97; 1.01\]0.434 \< 24 h1 24--48 h1.22 \[0.74; 2\]0.429 \> 48 h1.34 \[0.85; 2.12\]0.204Empirical antibiotic therapy1.019 \[0.73; 1.43\]0.914Subsequent septic shock3.070 \[1.9; 5.0\]\< 0.0001Empirical antibiotic therapy effective against *S. maltophilia*0.839 \[0.52; 1.35\]0.4705Effective combination antimicrobial therapy1.27 \[0.88; 1.83\]0.204Duration of effective antimicrobial therapy against *S. maltophilia*1.03 \[0.98;1.07\]0.243 \< 7 days1 7--14 days1.06 \[0.6; 1.86\]0.842 \> 14 days0.88 \[0.45; 1.71\]0.706Duration of effective combination therapyreal impact. Finally, if SAPSII and SOFA score were independently associated with mortality, no specific pneumonia or antimicrobial therapy-related factors impacted the outcome.

Our study population shares common features with previously published reports \[[@CR3], [@CR4], [@CR6], [@CR7], [@CR19]--[@CR23]\]. Indeed, *S. maltophilia* pneumonia develops in high-risk phenotypes patients, i.e., long ICU/hospital length of stay and duration of mechanical ventilation. Despite a mortality rate of approximately 50%, it is difficult to delineate direct attributable mortality of *S*. *maltophilia* HAP from mortality linked to underlying diseases \[[@CR24]\]. Indeed, the prolonged ICU length of stay preceding *S*. *maltophilia* isolation and the number of prior antimicrobial therapies suggest noticeable patient frailty and complicated medical history. These factors have been associated to high mortality in patients with resistant bacteria in ICU \[[@CR25]\]. *S*. *maltophilia* HAP


read and approved the final manuscript.

This study has been solely funded by the Department of Anaesthesiology and Critical Care Medicine of the University Hospital of Nancy, France. The Unit of Methodology, Data and Statistics kindly provided free of charge RedCap support.

The datasets analyzed in this study are not publicly available due to privacy issues, but are available from the corresponding author upon reasonable request.

This study was approved by the ethics committee of the Société Française d'Anesthésie et de Réanimation (IRB 00010254-2015-010; February 19, 2016). This study was the subject of a favorable decision from the Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé on April 20, 2017, and of a declaration to the Comission Nationale Informatique et Libertés onoil soap, feel pleasurable! The cocoa, vanilla and nutmeg delivers a bounty of antioxidants and phytonutrients to the skin while the milk cleanses and softens the skin. Enjoy it all you want and you wont gain an ounce.

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Central Otago was home to many chinese goldminers in the 19th century seeking their riches. These men worked hard, conditions were harsh and not all dreams were fulfilled. To honour our chinese history the ‘Goldminer’ olive oil soap is infused with green tea, refreshing aromas of sweet orange and lemongrass essential oil and gold shimmers of turmeric. Green tea is very toning to the skin, helping to reduce redness. The essential oils are very antiseptic helping to heal the skin while the citrus scent improves the mood. Turmeric has been shown to help topically with bruising, eczema, even out skin tone while gently exfoliating skin leavinga pilot line, through which pilot pressure is applied by the first hydraulic control lever 4 to the first working device control valve 7, communicates with the pilot line 11, through which pilot pressure is applied to the confluence valve 10 by the first hydraulic control lever 4. This causes pressure loss due to internal leakage or the like. Consequently, the operator cannot control the first working device as accurately as he or she desires.
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depending on the season, may have the need for such display banners several times per week. The cost of materials and the time required to design and produce these disposable banners can thus be quite significant. It would be expedient, therefore, for the provision of a durable, resilient, reusable, tear-through display banner as taught and claimed by the present applicant.for the point charge counterions. For sufficiently long rods, however, bridging contributes to the attractive interaction, where the correlation of the charges within the rods is important. In the strong coupling limit, the inter-ionic charge correlations dominate the attractive interactions at short separations between the charged nanoparticles.


House defeats $700B financial markets bailout

Julie Hirschfeld Davis

Monday

Sep 29, 2008 at 2:24 PM

WASHINGTON — In a stunning vote that shocked the capital and worldwide markets, the House on Monday defeated a $700 billion emergency rescue for the nation's financial system, ignoring urgent warnings from President Bush and congressional leaders of both parties that the economy could nosedive without it.

WASHINGTON — In a stunning vote that shocked the capital and worldwide markets, the House on Monday defeated a $700 billion emergency rescue for the nation's financial system, ignoring urgent warnings from President Bush and congressional leaders of both parties that the economy could nosedive without it.

Stocks plummeted on Wall Street even before the 228-205 vote to reject the bill was officially announced on the House floor.

As a digital screenbe meeting with members of his team later in the day "to determine next steps," said spokesman Tony Fratto.

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financial advice. The Silicon Valley Insider is a branding extension of its parent website, www.thewealthyventurecapitalist.com. The Silicon Valley Insider is not located in Silicon Valley as it is meant to be a pseudonym used in the coverage of Technology Companies. The Silicon Valley Insider’s parent company has been compensated twenty-three thousand three hundred and thirty-three dollars by GTX Corp. The information contained herein is based on sources which we believe to be reliable but is not guaranteed by us as being accurate and does not purport to be a complete statement or summary of the available data. Sometimes human error can attribute to honest mistakes in reporting on issues regarding public companies and overall capital markets, and as such we are not responsible for the complete accuracy inArgX, "addresult", BB);

  // Create the return instruction and add it to the basic block
  ReturnInst::Create(Context, Add, BB);

  // Now, function add1 is ready.
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static Function *CreateFibFunction(Module *M) {
  LLVMContext &Context = M->getContext();
  // Create the fib function and insert it into module M.  This function is said
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  }

  synchronize.releaseThreads(3); // wait until other threads are at this point

  void* returnValue;
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          std::cerr << "Could not join thread" << std::endl;
          return 1;
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  result = pthread_join( fibThread1, &returnValue );
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  std::cout << "Fib1 returned " << intptr_t(returnValue) <<cities. It is possible Mexico’s entire government will be rebuilt.

Third time’s a charm?

The favourite to win the Presidency is Andrés Manuel López Obrador (commonly called AMLO), a centre-left leader who lost in controversial circumstances in both the 2006 and 2012 presidential elections.

Mexican voters are in the mood for change and AMLO’s position as both an outsider and a modest man from humble origins is playing well this year. In the four-candidate race, recent polling shows him topping 50 per cent and with a nearly 2-to-1 lead over his closest rival.

AMLO has campaigned on eliminating corruption as the solution to all of Mexico’s current challenges. This clear and simple message has resonated with a restless electorate and blunted attacks from his opponents.

In addition to being an over-whelming favourite for


the Presidency, the party AMLO founded in 2012, the Movement of National Regeneration (MORENA), may gain an absolute majority in the Congress. This would be the first time any party has had unified control of the federal government since 1997.

Andrés Manuel López Obrador is running for President for the third time, and is the favourite to win on July 1. Picture: Getty Images

Evolution from the ‘perfect dictatorship’ to a modern democracy

On paper, Mexico has long been a democratic federal republic, with divided powers and three levels of government. The federal government rules over 32 autonomous states, each of which has executive, legislative and judicial powers of its own; while the municipalities have mayors and local councils as well. But despite these legal mechanisms, political power in Mexico, historically,in an ergonomical and natural position requiring very little effort.

DARIOS constantly measures the speed of the vehicle and adjusts its reponse to give you an optimal level of comfort and safety while driving. DARIOS never reduces the full engine power which remains available at any speed.

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The distance from idle to full throttle is only about 3/4 inch

The leather-coveredthat "had those big Bob Wills dance floors. ... I'd get up on the long bandstand, built for a twelve-piece cowboy orchestra, and I'd be telling my four guys to start spreading out."  He continues that the audience was frustrated by his songs he played that were difficult to dance to.

This was echoed on the 1990s cable television show Ryman Country Homecoming'', which featured country music legends discussing and playing some of their most famous songs to each other, host Ralph Emery asks him, "Waylon, were you like a lot of kids in Texas when you grew up, were you a big fan of Bob Wills?" To which Jennings replies, "No, I wasn't," provoking laughter from his fellow musicians, after which he added, "I liked two of


What Defines Good DUI Lawyer?

JON ARTZ DUI VIDEOS

“What Defines a ‘Good’ DUI Attorney?”

”

Video Transcript:

Many people might wonder: is a good criminal attorney good enough? Or someone who purports to be a good DUI attorney. The answer is, it depends. Is this an attorney who really goes to trial? And wins? Is this an attorney who will really work for you and develop the facts and the defenses so that you can be successful at the time of trial? Is this an attorney who will suggest to you about how you can use character evidence and other facts that can create a reasonable doubt? Will this attorney be aggressive in fighting the DMV? Many attorneys don’t understand the chemistry involved in a DUI trial. Many attorneys are either toobeen more fun”.

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Curated Playlists and Stations:


century, when the East India Company was granted a royal charter by Queen Elizabeth. The charter gave the East India Company a monopoly within Britain on trade with the Far East; the company would focus on India.

As the East Indian Company rapidly expanded in the 19th century, more and more employees moved to the “Country,” as India was known. They were posted to a new station in another part of India every three years, which exposed them to culinary traditions all over the subcontinent. When these British workers traveled around the subcontinent, they were carried in a litter by a team of men, the carriers traded out at roadside taverns like horses. The litter itself was misery, being shaped like a wooden coffin in which the traveler slowlyto combat this in a more principled manner by converting our Urdu sentences into an image and posting the images. This way, the cheating turkers will not be able to cut and paste into a machine translation system.

We also noticed that many of the translations had simple mistakes such as misspellings and typos. We wanted to investigate whether these would decrease the value of our test set so we did a second phase of data collection where we posted the translations we gathered and asked turkers (likely to be completely different people than the ones who provided the initial translations) to correct simple grammar mistakes, misspellings, and typos. For this post-editing phase, we paid \$0.25 USD per ten sentences, giving a total post-editing cost of \$44.80 USD.

In summary,


to our knowledge. They also have very similar performance on NIST2009 so we want to see if that similar performance is maintained as we evaluate on our MTurk-produced test sets. The third MT system (Joshua-Hierarchical) [@Joshua-WMT], an open source implementation of [@Chiang2007], was chosen because though it is a competitive system, it had clear, markedly lower performance on NIST2009 than the other two systems and we want to see if that difference in performance is also maintained if we were to shift evaluation to our MTurk-produced test sets.

Table \[t:systemRelations\] shows the results. There are a number of observations to make. One is that the absolute magnitude of the BLEU scores is much lower for all systems on the MTurk-produced test sets than on the NIST2009 test set. This isassociating physical activity with nature in cities allowing bicycle users to benefit from the positive health effects of nature-based solutions. Our study focuses on the potential of bicycle lanes to improve functional connectivity among green spaces. We administered 820 questionnaires in 34 green spaces (i.e., urban parks) in Bucharest, Romania, to identify the factors influencing the use of bicycle lanes connecting urban parks and to understand which planning criteria for bicycle lanes are considered as the most important by park visitors. We applied binary and ordinal logistic regressions and found that the factors affecting bicycle lane use are illegally parked cars and lack of accessibility to urban parks. The criteria preferred by park visitors for bicycle lane planning are determined by experience level and frequency of bicycle use.


Characteristics and outcome of prehospital paediatric tracheal intubation attended by anaesthesia-trained emergency physicians.
To collect data regarding prehospital paediatric tracheal intubation by emergency physicians skilled in advanced airway management. A prospective 8-year observational study of a single emergency physician-staffed emergency medical service. Self-reporting by emergency physicians of all children aged 0-14 years who had prehospital tracheal intubation and were attended by either anaesthesia-trained emergency physicians (group 1) or by a mixture of anaesthesia and non-anaesthesia-trained emergency physicians (group 2). Eighty-two out of 2040 children (4.0%) had prehospital tracheal intubation (58 in group 1). The most common diagnoses were trauma (50%; in school children, 73.0%), convulsions (13.4%) and SIDS (12.2%; in infants, 58.8%). The overall tracheal intubation success rate was 57 out of 58 attempts (98.3%). Compared to older children,:

Review: A really nice light scarf with good print quality.

Pros: silky
light
nice bright colors.

Cons: only printed on one side.

Bottom Line: Get this if you want a light pretty scarf for not much money.


by using water-soluble plasticizers in combination with water-soluble polymers, in a single phase aqueous system, a transparent matrix or base is obtained that, after drying, forms a film with an oil-like shine. The high gloss intensifies the hue of colorant-containing compositions, such as mascara and eyeliner, lipliners and lipglosses, providing a rich, deep color. The lipliners and lipglosses prepared according to the invention are particularly shiny and brilliantly colored. Moreover, the water- and oil-resistance and transfer-resistance properties of the lipliner products produced enable the user to enlarge or reduce the appearance of the size of the lips which is also highly desired by consumers.
A long-wearing product that resists smudging, running and/or or fading upon exposure to oils and perspiration or tears also would be appreciated by consumers. Thelaw, and very concerningly, has made some of these statements in school to our nation’s youth,” FDA acting Commissioner Norman “Ned” Sharpless said in a statement.

The agency’s warning letter highlights an incident recounted by two New York high school students during a congressional hearing in July. The students said a Juul representative was invited to address the school as part of an assembly on mental health and addiction issues. During the presentation, the students said, the representative told them the company’s product was “totally safe.” The representative also showed students a Juul device and claimed the FDA “was about to come out and say it was 99% safer than cigarettes.”

Juul says it discontinued its school programs — which were intended to discourage underage use — last September.

Among young


to the same spectral curve, the spectral curve of the immersion $f$.

A general point $\infty\in S^3$ at infinity that *lies on the image of the immersion* gives rise (as in Section \[sec:weierstrass\]) to a Dirac type operator with a non–smooth potential. However, in the special case that the resulting immersion into Euclidean 3–space is minimal (and then necessarily has planar ends), the corresponding Dirac operator has a trivial potential, i.e., is of the form with $U=0$.

The main result of the paper (Theorem \[the:main\]) is derived from the fact that the spectral curve of a Euclidean minimal torus with planar ends can be computed using this Dirac operator with trivial potential $U=0$ if one imposes suitable boundary conditions at the ends. The reducibility of the spectral curve then reflects the decomposition ofcurve of $f$ is thus of the form $\Sigma=\Sigma'\, \dot\cup\, \bar \Sigma'$ for $\Sigma'$ a Riemann surface of finite genus with one end. More precisely $\Sigma'$ is the spectral curve belonging to an elliptic KP soliton, see Appendix \[app:elliptic\_KP\]. Theorem \[the:main\] holds more generally for Euclidean minimal tori with planar ends and translational monodromy like Riemann’s “staircase” minimal surfaces, see Section \[sec:riemann\].

The basic idea behind the proof is similar to that of Theorem \[the:moebius\_inv\_of\_spec\]. An essential difference is that here we chose a point $\infty$ at infinity for which the immersion has ends, i.e., goes through $\infty$. As a consequence, the corresponding flat connection $\nabla$ on $V/L$ with $\nabla\psi_1 =0$ (cf. Appendix \[sec:weierstrass\]) is only defined away from the ends, because the section $\psi_1$ vanishes at the ends. Our strategy in order to determine


smooth elsewhere so that by integration $g_2$ is $C^0$ at the ends. But now $d\chi_2 = -df^{-1}
  g_2$ implies that $\chi_2$ is $C^1$ at the ends. The holomorphic section $\psi_1 \chi = \psi_2 \chi_2$ is thus $C^1$ at the ends and hence smooth by elliptic regularity.

So far we have shown that holomorphic sections $\psi^h$ of $V/L$ with monodromy $h$ correspond to pairs of meromorphic functions $\Phi_1$ and $\Phi_2$ with monodromies $h\cdot h_0$ and $\bar h\cdot
  h_0$ and prescribed pole behaviors. Because for generic points of the spectral curve the corresponding space of holomorphic sections of $V/L$ with monodromy $h$ is complex 1–dimensional (Appendix \[sec:spectral\_curve\]), generically either $\Phi_1$ or $\Phi_2$ has to vanish identically. (Otherwise they would give rise to a complex 2–dimensional space of holomorphic sections withare parametrized over rectangular tori and appear in our setting for $\omega_1\in {\mathbb{R}}$ and $\omega_3\in i{\mathbb{R}}$. Because this implies $b_2=\bar b_1$, for $\gamma_{m,n}$ with $mn=0$ and the corresponding choice of $a$, equation is then automatically satisfied. The parametrizations of Riemann’s minimal surfaces thus obtained essentially coincide with the ones given in [@HKR].

Riemann’s minimal surfaces have previously been characterized using algebro geometric KdV theory in the work of Meeks, Perez, and Ros [@MPR; @MP]. It would be interesting to conceptually relate the way KdV theory appears in their work with our approach based on spectral curve theory.

Some notions of quaternionic holomorphic geometry {#app:quat_hol}
=================================================

We review the relevant notions of quaternionic holomorphic geometry [@PP; @FLPP01; @BFLPP02]. In particular we discuss the quaternionic holomorphic approach [@BPP09; @BLPP] to the spectral curve of


conformally immersed tori [@Ta98; @GS98; @Ta04; @Ta06].

Quaternionic holomorphic line bundles {#app:linebundles}
-------------------------------------

A *quaternionic holomorphic line bundle* over a Riemann surface $M$ is a quaternionic line bundle $L$ equipped with a complex structure $J\in \Gamma(\operatorname{End}L)$, $J^2=-\operatorname{Id}$ and a quaternionic linear (Dirac type) differential operator $D\colon \Gamma(L) \to \Gamma(\bar
KL)$ satisfying the Leibniz rule $$D(\psi \lambda) = (D \psi)\lambda + (\psi d\lambda)''$$ for all $\psi \in \Gamma(L)$ and $\lambda\colon M \to {\mathbb{H}}$, where $\omega'':=\frac12(\omega + J{*}\omega)$ and $\bar K L$ denotes the bundle of 1–forms with values in $L$ that transform like $*\omega =
-J \omega$ for $*$ the induced complex structure on $T^*M$. The degree of a quaternionic holomorphic line bundle is defined as the degree of the underlying complex line bundle $E := \{ \psi \in L \mid J\psi
=\psi {i}\}$. Thefunction in $x$, $y$, $t$ which is a meromorphic solution to the KP equation. This solution can be obtained from the Baker–Akhiezer function which is characterized as the section of a family of holomorphic line bundle on the Riemann surface. Its dynamics in $x$, $y$, $t$ is given by linear flows in the Jacobian, realized by cocycles which linearly depend on $x$, $y$, $t$ and describe the change of holomorphic line bundle. An elliptic KP soliton as described in [@Kr] is precisely a finite gap KP solution that is double periodic in the $x$–variable. As in the case with two punctures (see e.g. p.665 in [@Hi]), the existence of a pair of 1–forms $\eta_1$, $\eta_2$ with the given asymptotics and periodicity means that there is a pair of $x$–values


a $2$–torus to the $3$–sphere. *J. Differential Geom.* **31** (1990), 627–710.

I. M. Krichever, Elliptic solutions of the Kadomtsev-Petviashvili equation and integrable systems of particles. *Funct. Anal. Appl.* **14** (1980), 282–290.

R. Kusner and N. Schmitt, The spinor representation of minimal surfaces, [arXiv:dg-ga/9512003](http://arxiv.org/abs/dg-ga/9512003v1).

F. J. Lopez, M. Ritore, and F. Wei, A characterization of Riemann’s minimal surfaces. *J. Differential Geom.* **47** (1997), 386–407.

W. H. Meeks, J. Perez, and A. Ros, Properly embedded minimal planar domains, Preprint 2007.

W. H. Meeks and J. Perez, Properly embedded minimal planar domains with infinite topology are Riemann minimal examples. In *Current Developments in Mathematics* Volume 2008 (2009), 281–346.

F. Pedit and U. Pinkall, Quaternionic analysis on Riemann surfaces and differential geometry. *Doc. Math. J. DMV*, Extra Volume ICM Berlin 1998, Vol. II, 389–400.

U. Pinkall and I. Sterling, On the classification of constant mean curvature tori. *Ann. of Math.* **130** (1989), 407–451.

E. I. Shamaev, On one family of minimal tori in ${\mathbb{R}}^3$ with planar embedded ends. *Sibirsk. Mat. Zh.*language during the brawls for which that game became infamous. Melai continued to play football at suburban level until 1979. In the early 1990s, he served as a runner and team manager for the St Kilda Football Club.

Melai died at age 63 after suffering a stroke in April 2004. Later that year he was named as the ruckman of Dandenong's Team of the Century.

References

External links

Category:1941 births
Category:2004 deaths
Category:Dandenong Football Club players
Category:Sydney Swans players
Category:East Geelong Football Club players
Category:Australian rules footballers from Victoria (Australia)


want. You can also upgrade your Prime Music membership to access more songs.

Twitch Prime: Twitch is a video game streaming service that was purchase by Amazon. If you’re a Prime subscriber, you get certain ‘premium’ features, such as ad-free streaming.

Prime Photos: With Prime, you can access unlimited cloud storage from Amazon for all of your photos.

Kindle owners’ Lending Library: If you have a Kindle, you can borrow one Kindle eBook per month for free.

Prime early access: Prime members always get early access to Amazon’s Lightning Deals.

uSwitch Limited is authorised and regulated by the Financial Conduct Authority (FCA) under firm reference number 312850. You can check this on the Financial Services Register by visiting the FCA website.Specific changes in levels of autoantibodies to glutamate and opiate receptors induced by morphine administration in rats.
Several groups of brain receptors are involved in the mechanisms underlying the development of opiate addiction, but the interactions occurring between these neuroreceptors and the immune system, including potential autoimmune responses, remain poorly understood. We studied in rats the effects of repeated administration of different psychotropic drugs on serum levels of autoantibodies (aAbs) to the mu delta-opiate receptor (MDOR), as well as to the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) GluR1 and to the N-methyl-D-aspartate (NMDA) NR2 subunits of the glutamate receptor, as analyzed by ELISA. We found that repeated administration of morphine significantly elevated aAbs levels to MDOR and to the AMPA GluR1 subunit, but not to the NMDA NR2 subunit. In contrast, a


895 A.2d 319 (2006)
2006 ME 40
STATE of Maine
v.
Gregory D. SMEN.
Supreme Judicial Court of Maine.
Submitted on Briefs: March 22, 2006.
Decided: April 26, 2006.
*320 Michael E. Povich, Dist. Atty., Mary N. Kellett, Asst. Dist. Atty., Ellsworth, for State.
Jeffrey C. Toothaker, Toothaker & Chong, Ellsworth, for defendant.
Panel: SAUFLEY, C.J., and CLIFFORD, ALEXANDER, CALKINS, LEVY, and SILVER, JJ.
CLIFFORD, J.
[¶ 1] Gregory D. Smen appeals from judgments of conviction for one count of violation of a protection from abuse order (Class D), 19-A M.R.S. § 4011(1)(A) (2005); one count of terrorizing (Class D), 17-A M.R.S. § 210(1)(A) (2005); and one count of failure to sign a uniform summons and complaint (Class E), 17-A M.R.S. § 15-A(1) (2005), entered in the District Court (Ellsworth, Brodrick, A.R.J.) following a non-jury trial. Smen contends that insufficienthe wished to stop at "the old lady's house" and beat up his wife and her boyfriend.
[¶ 5] The State charged Smen with one count of violation of a protection from abuse order (Class D), 19-A M.R.S. § 4011(1)(A); one count of terrorizing (Class D), 17-A M.R.S. § 210(1)(A); and one count of failure to sign a uniform summons and complaint (Class E), 17-A M.R.S. § 15-A(1). Smen pleaded not guilty to all three offenses.
[¶ 6] Following a trial, the court found Smen guilty of all three offenses. The court imposed identical sentences for the terrorizing and violation of a protection order counts  nine months incarceration with all but sixty days suspended and one year of probation, those sentences to be served concurrently.[2] Smen filed this appeal.

II.


"[a] temporary, emergency, interim or final protective order" if the defendant "has prior actual notice" of the existence of the order. 19-A M.R.S. § 4011(1)(A). In this case, the State presented evidence that Smen's wife obtained a protection from abuse order against Smen that prohibited Smen from contacting her, that Smen was present at the protection from abuse hearing, and therefore had prior notice of the provisions of the order, and that after the protection order was issued, Smen called his wife at the residence where she resided with her boyfriend and spoke to her.
[¶ 9] Smen argues that this evidence is not sufficient to support his conviction on *322 this count because he did not know his wife was residing at that location, and that he wasto whom the communication is made or another, and the natural and probable consequence of such a threat, whether or not such consequence in fact occurs, is . . . [t]o place the person to whom the threat is communicated or the person threatened in reasonable fear that the crime will be committed.
17-A M.R.S. § 210(1)(A). In this case, the State produced evidence at trial that Smen communicated to the wife's boyfriend that he intended to kill him.
[¶ 10] Smen argues that the evidence is insufficient to prove that he terrorized the boyfriend because the boyfriend never testified that he feared Smen might actually try to kill him. Section 210(1)(A), however, does not require that the State prove actual fear on the part of the victim. The statute


expressly requires only that the natural and probable consequence of conveying the threat is to create reasonable fear in the victim, whether or not the victim actually experiences such reasonable fear. 17-A M.R.S. § 210(1)(A). In this case, a fact-finder could and did find that the natural and probable consequence of Smen's threat that he would kill the wife's boyfriend would be to put the boyfriend in reasonable fear that Smen would do so, whether or not the boyfriend actually feared that Smen would kill him. Thus, the evidence supports the court's finding beyond a reasonable doubt that Smen terrorized the boyfriend of his wife.
[¶ 11] We do, however, note an error in the court's sentencing of Smen on Count II, the terrorizing count. The court sentenced Smenchar_AAA'; // ILLEGAL, reason: constant content, movable pointer
// char_AAAA = 'Changed char_AAAA'; // ILLEGAL, reason: constant content and pointer!

printf("\n\n"
       "char_A: %c\n"
       "char_AA: %c\n"
       "char_AAA: %c\n"
       "char_AAAA: %c\n"
       " \n\n"
        , char_A, char_AA, char_AAA, char_AAAA);

//*char_AAA = char_A; // allowed because only the content cannot be changed (does not work with char array but works with other format, I believe)
// *char_AAAA = &char_AA; // ILLEGAL, reason: constant content and pointer!

printf("\n\n"
       "char_A: %c\n"
       "char_AA: %c\n"
       "char_AAA:


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            .attr("y", chart.yAxis.scale()( rec_data.y1 ) - chart.margin().top )
            .attr("width", chart.xAxis.scale()( rec_data.x2 ) - chart.xAxis.scale()( rec_data.x1 ) )
            .attr("height", chart.yAxis.scale()( rec_data.y1 ) - chart.yAxis.scale()( rec_data.y2 ) )
            .attr("fill", "red")
            .attr("opacity", 0.5);

   });
}
draw();
<script src="https://ajax.googleapis.com/ajax/libs/jquery/2.1.1/jquery.min.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/d3/3.4.11/d3.min.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/nvd3/1.8.5/nv.d3.js"></script>
<link href="https://cdnjs.cloudflare.com/ajax/libs/nvd3/1.8.5/nv.d3.css"  rel="stylesheet" />
<div id="qc_overtime_id">
  <svg style="width:1300px;height:550px;"></svg>
</div>

especially in areas which lack pregnancy surveillance programmes. To prevent neonatal transmission, safe feeding practices should be encouraged and retroviral drugs should be available. The increasing focus and investments in HIV prevention are possible explanations for the decline of the epidemic.


dental admissions. The counselling is likely to begin in the third week of July after the Centre completes counselling for seats in the all India quota. This year, for the first time, the state will conduct counselling for 24 government medical colleges as well as an almost equal number of seats in self-financing colleges and deemed universities.

Tamil Nadu, which scrapped entrance examinations for professional courses more than a decade ago, has been opposing a common entrance examination for MBBS BDS admissions. The state health minister C Vijaya Bhaskar tabled two Bills in the assembly to exempt the state from NEET for both undergraduate and postgraduate courses even after the Supreme Court made NEET mandatory in April 2016.The Act, however, is yet to be sent by the Centre for:-)

You won't regret this.

But it would be a good idea NOT to eat the whole thing in one sitting.

Note: If it tastes too eggy, then it's been underbaked. If it's not incredibly moist and delicious, then it's been overbaked.

Recipe, quick recap:

Crust:

1/2 c. butter

1 c. flour,

3 T. cold water

Mix and divide in half and pat into 2 11-12" strips on jellyroll pan.

2nd layer:

Spread appx. 1/2 c. apricot preserves onto crust strips.

3rd layer:

1 c. flour

1/2 c butter

3 eggs

1 c. water

1 t. almond extract

1/2 t. vanilla extract

Bring butter and water to boil and stir in flour. Stir until it thickens. Beat eggs in one at a time. Whisk while cooking until mixture is very thick and spreadable. Whisk in flavors. Spread evenly over apricot layer and bake 350 degrees for 49


27 years worth of accumulated stuff) is making all the gray days somewhat more tolerable. And, of course, any day that I'm able to actually get outdoors and walk on dry blacktop roads is so encouraging. Walking indoors in a mall is incredibly boring, whereas walking in the neighborhood in the brisk air is so refreshing - and just what I need.

A favorite thing - walking outdoors

Photo from November.

Photo taken from the bottom of our driveway, last week.

2. What's something you can't eat without salt? Do you normally salt your food a lot, a little, or not at all?

I salt my food 'a little.' I could probably eat almost everything without salt, because I'm not a salt lover.

3. Sands of time, bury your head in the sand, builton sand, or draw a line in the sand...which sandy phrase could best be applied to something in your life right now?

Definitely not a 'bury your head in the sand' kind of person, I like reason behind what I think and do, so not 'built on sand,' and I don't enjoy confrontation, so not 'draw a line in the sand.' That leaves 'the sands of time,' and since I've lived a very long time, that one would most likely apply.

4. A favorite book, movie, or song with an island setting or theme?

I loved the movie Island at War about the German occupation of one of the Channel Islands and the book The Guernsey Literary and Potato Peel Pie Society, but my first thought when I hear 'island' is


weekend of snow and cold.

Transporting logs

7. Share with us a song that makes you feel nostalgic? For what?

Several classical music pieces remind me of homeschooling our kids to a background of classical music. OR many British mystery theme songs which remind me of the Thursday evenings we watched PBS Mystery and shared a Bounty bar (like Mounds but thicker dark chocolate).

8. Insert your own random thought here.

Just a pic of the kitties, because I know you are dying to see them! :-)

I lay down on the [single] bed for a few minutes to check my email (on my phone) and take a quick nap, and by the time I got ready to pull the blanket over myself, you-know-who(s) had appropriated it and I didn't have the heart toalways is seeing the grandchildren playing together. The least beautiful thing was Irvine Park Christmas Village with 60,000 lights and displays when you arrive before dark. Definitely diminishes some of its charm. So we went and hung out at Leinie's Lodge in Chippewa Falls until it got dark and then tried again. MUCH better. Next year we will arrive at 6:30 PM rather than 5:00 PM. And we will walk through, rather than drive through.

On the way to Chippewa Falls
Car rides affect me the same way.

Killing time until it got DARK Leinie's Lodge: The place to loiter if you want to stand next to a beautiful fireplace while you're waiting for it to get dark outside, or if you want to purchase one of a zillion items that


relationship, the yearning for beauty. And God, the true God, is the God we see in Jesus of Nazareth, Israel's Messiah, the world's true Lord." - N.T. Wright

Wait, Mr. C., just one more

ILLUMINATION

Welcome to my blog! My name is Judy, and except for a couple brief intervals, I've lived in Wisconsin all my life. I married the neighbor boy many years ago and we're still best friends. Our family of two has expanded to 19, including children and grandchildren. Of course that's before we start counting the dogs and cats.name="source">
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        /// a query builder or some other object representing the data set.
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        /// able to slice the data.
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to seriously consider,
or at least seriously consider running the opposite way as fast
as you can!

First, a quick note: The Gut Check would like to thank all of you
that sent feedback on the unveiling of his 2005
Crank Scores. Yours Truly’s projected Crank Scores were
of particular interest to many readers—especially the ranking
of Tiki Barber as the #3 RB on the cheat
sheet. One reader in particular made an excellent point about
Barber and it has The Gut Check adjusting his rankings as a result:

Hey Matt,

I'm a big Gut Check fan, and I especially loved the Crank
Articles you recently published and I'm intrigued by all the
possibilities of what could be done with them. After looking
over the scores, I think I may have figured out why Tiki Barber
is ranked so high. I think Tikifirst preseason game
because Gruden doesn’t need to see anything more from him.
This lack of playing time in game one is a positive sign that
Gruden envisions Williams carrying the load for Tampa. Based on
the average ranking of defenses versus the run on their schedule,
the Bucs have the most favorable schedule when it comes to running
the ball. Yours Truly has drafted Williams in four leagues thus
far and hopefully more before the season begins. He’s easily
available as a #3 fantasy RB in terms of rounds or price in standard
or auction drafts, respectively.

Speaking of favorable defensive schedules, Steve
McNair has the third-easiest schedule of pass defenses
this year. As most already know, the Titan has dropped 25 pounds
in the off-season—the first where he’s been 100% healthy
in several years. What has The Gut Check most


tight
end despite the fact that Tony Gonzalez remains one of the premier
players at the position. Wilson picked up where he left off in
2004 training camp prior to his season ending injury. So much
so, the Chiefs will compensate for their lack of a great receiving
corps with a heavy dose of Gonzalez and Wilson creating mismatches
in a variety of spots all over the field. Wilson is generally
un-drafted in most fantasy leagues. Yours Truly picked up Wilson
last week in round 20 as his second TE. At worst, The Gut Check
can find a suitable #2 TE on the waiver wire if Wilson doesn’t
pan out—but he’s not anticipating it will be necessary.

The Gut Check has two available waiver wire picks at the quarterback
position for dynasty league owners—Panthers rookie QB Stefan
LeFors and second-year Broncosprice of a #2 WR. The
Gut Check believes Bennett's torrid stretch run
was a product of his hard work and not Billy Volek.
McNair is still the better QB an Bennett will benefit.
So will Yours Truly.

WR

Isaac Bruce

8

A steal. Bruce is a quality #2 FF WR,
capable of #1 FF WR numbers. Age shouldn't matter
this year.

WR

Jimmy Smith

12

See comments on Isaac Bruce. Jacs have
best schedule of passing defenses in 2005.

TE

Boo Williams

1

Not a great pick, but could still win
the starting job. Has worked hard to regain his form,
though.

K

Jason Elam

1

Excellent distance kicker in a division
where scoring won't be lacking.

DEF

Washington

3

An underrated defense because the offense
was so bad. If Gibbs improves the "O," expect
the "D" to reap the rewards.

B-QB

Billy Volek

1

Didn’t have much to chose from, because
The Gut Check is betting on Manning.

B-QB

Gus Frerotte

1

See above. Plus Yours Truly


by outgoing titleholder Natalie Glebova of Canada. At the time she was the youngest Miss Universe winner since Amelia Vega in 2003 (until Stefanía Fernández in 2009).

Later that evening, Rivera fainted briefly during a press appearance.  The incident was reportedly attributed to heat exhaustion (from the stage lights) coupled with the weight of the heavy, chained dress she was wearing.

Rivera was the fifth Puerto Rican to win the title, which makes the island the third most successful entity in the pageant (behind the United States and Venezuela).  Rivera was the third consecutive delegate from Puerto Rico to make the Top 5 at Miss Universe, after Alba Reyes placed 2nd Runner-Up in 2004 and Cynthia Olavarría placed 1st Runner-Up in  2005. She is also the first"only ticket of admission here today is an open mind." Based on 8,000 pages of government documents released under the Freedom of Information Act (FOIA), Hastings contends that the U. S. Government has perpetrated a covcrup concerning the validity and nature of UFO sightings. This coverup continues today. Hastings doesn't condemn the government agencies but thinks the public has a right to know.the truth. In addition to the White House, the agencies most involved are the CIA and the National Security Agency. (NSA) He maintains that these documents prove UFOs do exist and that the government has determined they are of extraterrestrial origin. But the government wanted to "to minimize concern as to prevent possible panic," he quoted from a government memorandum. Among the incidents he says were


organization is Niemi, the one that played in the WHL. Also of note are the three Russians drafted. Max Gratchev played in the OHL and was released from the organization prior to last season. He spent this season bouncing between the ECHL and the AHL in the Senator's organization. Anton Klementyev was signed right after he was drafted and played in Bridgeport this past year. The other, some dude named Petrov, is currently playing in Russia although possibly not for long.

So will the new agreements affect the Isles draft strategy? It sure doesn't look like it. Even when drafting non-North American players, Snow and Jankowski prefer those who will be playing in North America the season after the draft. Of the twenty players drafted in the last threesexual coercion by powerful Hollywood men. “It is a world of victims,” he says. “I think some people did very well out of meeting with Harvey and others didn’t. The ones who did knew what they were doing. These are adults, we are talking about adults with a lot of ambition.” Humans, he elaborates helpfully, “are physical creatures.”

And then there’s Damon, who was criticized for his tone-deaf comments about the “spectrum” of sexual behavior — and subsequently apologized, admitting that “I really wish I’d listened a lot more before I weighed in on this” — which in Gilliam’s mind, is the equivalent of a brutal murder. While plenty of people on the internet have claimed to die of embarrassment, this would make Damon the first star to have


Report page 246, Statement 12.1). State funding should also be linked to the use of such criteria in admissions by the educational institutions.Establish Equal Opportunity Commission in Delhi. (Modalities were finalized by Central Govt's Expert Committee 5 years ago) 4.Institute in Delhi the Schemes for Incentives based on Diversity Index. (Modalities were finalized by Central Govt's Expert Committee 5 years ago).Give option for interest-free finance in the banking sector. Implement the recommendations of Raghuram Rajan Committee on financial sector reforms of the erstwhile Planning Commission.Create Special Component Plan in the Budget for Muslims for skill development programs and other economic opportunities. ('Promises to Keep' by Harsh Mandar & others)De-reserve constituencies with substantial Muslim presence. Create a cell in the CM's office to carry out research and collect data.Don King controlled the heavyweight championship at this time. The champions were the WBC’s Frank Bruno, the WBA’s Bruce Seldon and the IBF title was to be contested later in the year by Michael Moorer and Axel Schultz. Bruno was making the first defense of his WBC title. He had won the title six months previously

on an emotional evening at Wembley Stadium, London by out-pointing Oliver McCall In what was Bruno’s fourth attempt after unsuccessful shots at Tim Witherspoon, Mike Tyson and Lennox Lewis. There were calls for Bruno to defend his title against British rival Lennox Lewis. Three years previously, Lewis successfully defended against Bruno in a voluntary defense. Lewis was at the time WBC number one contender until for one reason or another, Mike Tyson was


two would meet on March 16 1996, and as in the first fight, Bruno’s army of fans crossed the pond to take over the Las Vegas arena. It was almost as though Bruno was fighting at home. However, the occasion seemed to be too much for Bruno as he crossed himself countless times in his walk to the ring. Tyson looked his usually menacing self. Before the fight, Tyson said that he had no choice but to win and these were certainly ominous words for the champion. Both men were heavier than in their previous meeting with Bruno scaling 247-pounds and Tyson-220.

In round one, Tyson charged at Bruno but Bruno landed a couple of good shots, but already was given a warning by referee Mills Lane for hisanxious wife.

That evening, Aleksandrov told Stashinsky that everything was ready for his departure. He would go to Germany on a military plane the next morning and would need to be ready by 5 a.m. Aleksandrov would collect him near his apartment building. He asked Stashinsky to turn in all his KGB-issued documents and passes before leaving for Germany, keeping his travel document only. It was issued, as always, in the name of Aleksandr Krylov.

But in direct violation of Aleksandrov’s instructions, Stashinsky took the Joseph Lehmann identity card—his original identity—with him, which was good until April 1970, and a driver’s license in the same name. He also pocketed his Soviet passport and a Foreign Languages Institute student identity card, both issued in his real name. To these, he added


but failed to develop a plausible plan: “Where do you evacuate to when the world is about to end?”

The CIA officers in West Berlin began to activate emergency links with their agents on the other side of the rapidly rising wall. They also monitored the situation on the ground in West Berlin, where the locals were growing angry at the lack of Western response to Soviet actions.

Once the initial panic at the CIA Berlin base was over, and they realized there’d be no invasion, Bogdan Stashinsky was flown from besieged West Berlin to Frankfurt, where he would spend the rest of the month in CIA custody. As attested by CIA veteran William Hood, “when possible” (as Hood wrote about his experience in Vienna), the CIA tried to transferdefectors promptly from places where the Soviets could get at them.

Stashinsky was flown to Frankfurt on August 13, 1961, while Inge stayed behind and was interrogated separately by the West German authorities. Stashinsky would be housed in a block of buildings used by the CIA and U.S. Army personnel, and there he would be interrogated repeatedly by CIA officers.

The first of the many problems that CIA interrogators faced in dealing with Stashinsky’s testimony, both in Berlin and then at the CIA interrogation center in Frankfurt, was that they could not establish his identity. The many documents he produced had three different names on them: Bogdan Stashinsky, Joseph Lehmann and Aleksandr Krylov. The CIA officers did not know which of them, if any, was authentic. The CIA also had


bankruptcy on January 3, 2011. Barry Levinson, of Barry Levinson & Associates,[3] was their counsel. On March 9, *907 2011, Bank of Nevada, a creditor, moved to dismiss or convert the Debtors' case to another chapter. On May 6, 2011, the court entered an order granting the motion. The order gave the Debtors to convert or dismiss the case within thirty days.
On June 1, 2011, the Debtors entered into a stipulation with Rick A. Yarnall (the "Chapter 13 Trustee"). The stipulation provided that the Debtors were to voluntarily convert their case to one under Chapter 7 or voluntarily dismiss their case by June 9, 2011, and that, in the event the Debtors failed to pursue either of those alternatives, the Chapter 13 Trustee would have the option tosomehow, in the second motion, sufficient to justify an order shortening time. Nor would the reasonably competent attorney have advocated on behalf of such a motion without some modicum of knowledge as to its possible legal basis.
Unlike the reasonably competent attorney, Mr. Levinson filed an OST Motion that included a lengthy quotation of Civil Rule 60 and a statement of facts of about 10 lines, but no legal analysis whatsoever. Mr. Levinson did not cite to any legal authority that permitted the filing of a motion for an order shortening time for a motion identical to one the court had already heard, and denied, on regular time. Worse, Mr. Levinson neglected to disclose the court's previous denial altogether. Mr. Levinson simply made a few modifications to the previously


break;
	 if (ch != '+') die_readformat();
	 klen = 0;
	 for (;;) {
		get(&ch);
		if (ch == ',') break;
		if ((ch < '0') || (ch > '9')) die_readformat();
		if (klen > 429496720) { errno = error_nomem; die_write(); }
		klen = klen * 10 + (ch - '0');
	 }
	 dlen = 0;
	 for (;;) {
		get(&ch);
		if (ch == ':') break;
		if ((ch < '0') || (ch > '9')) die_readformat();
		if (dlen > 429496720) { errno = error_nomem; die_write(); }
		dlen = dlen * 10 + (ch - '0');
	 }

	 if (cdb_make_addbegin(&c,klen,dlen) == -1) die_write();
	 h = CDB_HASHSTART;
	 for (i = 0;i < klen;++i) {
		get(&ch);
		if (buffer_PUTC(&c.b,ch) == -1) die_write();
		h = cdb_hashadd(h,ch);
	 }
	 get(&ch);
	 if (ch != '-') die_readformat();
	 get(&ch);
	 if (ch != '>') die_readformat();
	 for (i = 0;i < dlen;++i) {
		get(&ch);
		if (buffer_PUTC(&c.b,ch) == -1) die_write();
	 }
	 if (cdb_make_addend(&c,klen,dlen,h) == -1)get into spring, then i will do my adn at southwestern.. no problemo.. still sucks though.
are you sure-sure that they do it alphabetically? *frowns*

OOOPS! Sorry chickadee77, I re-read my friend's text and she they "probably did it alphabetically." Don't give your hopes up yet! =)

Jul 2, '09

Joined: Jun '09; Posts: 18; Likes: 2

Good Morning everyone! Has anyone received any calls or letters today?

Jul 2, '09

From:
US
;
Joined: Jun '09; Posts: 10; Likes: 2

I got my call this morning! and no one should panic...each phone call lasts like 3-4 minutes..so it takes a long time to get through the whole list!

Jul 2, '09

Joined: Jun '09; Posts: 18; Likes: 2

Congratulations!!! That is so awesome. Do you mind me asking how many points you had?

Jul 2, '09

From:
US
;
Joined: Jun '09; Posts: 10; Likes: 2

Thank


a browser session.
One example format of a deep link may be a URL with a custom scheme. For example, for the YP business directory app, a scheme of “YP” may be registered with the operating system. A deep link for a business with an ID of 123 may be “yp://id/123,” although no consistent format is required for such custom scheme deep links. As another example, a deep link may appear to be a standard HTTP URL, such as “HTTP://yp.com/business/123.” Although this is a standard URL that can be passed to a browser, if the YP app has been installed, the domain “YP.com” may have been registered with the operating system so that the URL will be passed to the YELP app instead of to the browser.
Some mobile browsers,to read information from the app in order to send the correct UI events, an accessibility interface may be used. The accessibility interface may be provided by the operating system to privileged apps to allow UI automation. The term deferred deep-linking may refer to any access mechanism that first installs the application prior to navigating to the desired state.


The use of solar power has become quite common as a means to provide power for man-made structures to include both residential and commercial buildings. With the increased cost of energy from traditional sources such as fossil fuels, coupled with a transition in industry towards eco-friendly or “green” technologies, building architectures and designs continue to evolve to incorporate solar power systems.
Solar panel arrays are often installed on existing buildings. In most cases, the solar panels are mounted on the roof of the building, and therefore are limited in terms of the amount of solar panels that can be used to produce power. When land is available, an increased number of solar panel arrays can be situated at a location adjacent the building(s) to be powered, however increasing solarpanels in this manner is not a viable solution for powering buildings within most cities.
In extreme climate conditions such as desert or arctic environments, solar power can be a useful means of power generation for a building; however, other traditional power sources typically have to be included to supplement shortcomings with the solar power supply. For example, it is rare that a solar panel array in a larger building located in a desert climate will be capable of powering high energy consumption cooling systems, such as the building's HVAC systems. Similarly, in colder climates, while solar panels may provide enough power for electrical lighting, it is uncommon for solar panels to be able to produce enough energy to effectively heat the building.
There are a great number of patents


Calculate -7*m(t) + 4*w(t).
-509*t**3
Let s(r) = -453*r + 448*r + 7 + r**2 + 0*r**2. Let a(b) = -1. Let o(z) = 2*z - 9. Let k(m) = -6*a(m) + o(m). Suppose 5*t - 14 + 24 = 0. What is t*s(v) - 5*k(v)?
-2*v**2 + 1
Let j(n) = n**2 + n + 1. Let s(v) = 4*v**3 + 5*v**2 + 5*v - 14. Determine 5*j(q) - s(q).
-4*q**3 + 19
Let f(t) = t + 1. Let k(n) = 26*n + 13. Let i(m) = -m**3 - 11*m**2 - 3*m + 57. Let h be i(-10). Calculate h*f(c) + k(c).
13*c
Let u(m) be the third derivative of 2*m**5/15 + m**4/12 + m**3/6 - 11*m**2 + 4*m. Let c(h) = 9*h**2 + 2*h + 1. Determine 6*c(k) - 7*u(k).
-2*k**2 - 2*k -Q:

url returning none in django

I am running a website with python and Django . I have made all changes that are required to run.
urls.py:
urlpatterns = [
url('index.html', views.index, name='index'),
url('admin/', admin.site.urls),
url('', views.user_login, name='user_login'),
url('dashboard', views.obs_index, name='admin_dash'),
url('halls/active', views.obs_halls_active, name='active-halls'),
url('halls/pending', views.obs_halls_pending, name='pending-halls')
]

obs_index.html:
{% block bookings %}

      Bookings

 By Users

 By Owners

{% endblock %}

When i run and click on the bookings menu, it is not working.


permutations) ([Figure 1c](#fig1){ref-type="fig"}). Moreover, QT/QRS GWAS enhancers are enriched for DHS and Cap Analysis Gene Expression (CAGE) signals in human fetal heart, both of which are marks of greater enhancer activity ([Figure 2](#fig2){ref-type="fig"}) ([@bib38]; [@bib3]). Finally, QT/QRS left ventricular enhancers show significant evolutionary conservation across the primate lineage compared to non-GWAS LV enhancers (p=6.82x10^-5^ compared to 10^5^ size-matched sets of LV enhancers), suggesting that perturbation of these enhancers is under stronger negative selection. Taken together, QT/QRS loci preferentially overlap conserved enhancers that show cardiac-restricted activity, suggesting that common variants associated with these loci play roles in regulating cardiac functions that drive human phenotypes.

Common features in GWAS cardiac enhancers identify novel sub-threshold loci {#s2-2}
---------------------------------------------------------------------------

Current GWAS loci collectively explain only a small fraction of the estimated heritability of a complexloci that reach genome-wide significance in the larger meta-analysis cohort but were not discovered in any previous GWAS (and therefore were not included in the 112 QT/QRS loci used for enrichment analyses above, gold dots, *bottom,* [Figure 3](#fig3){ref-type="fig"}). We observed that active LV enhancers are strongly enriched for loci harboring SNPs with p-values between 1x10^-4^ and 5x10^-8^ ([Figure 3a](#fig3){ref-type="fig"}, black line). Furthermore, the combination of functional features identified for above-threshold QT/QRS enhancers ([Figure 2](#fig2){ref-type="fig"}) substantially improves sub-threshold locus enrichment across a wide range of p-value thresholds ([Figure 3a](#fig3){ref-type="fig"}, colored lines, [Figure 3---figure supplement 1](#fig3s1){ref-type="fig"}).10.7554/eLife.10557.008Figure 3.Cardiac enhancers harbor additional sub-threshold QT loci.(**a**) *Top*, Enhancer characteristics learned on above-threshold QT/QRS loci from [Figure 2](#fig2){ref-type="fig"} are predictive for additional sub-threshold loci (colored lines). Each point on a curve represents the fold


monocytes. Tissue type was chosen using results by [@bib16] computing enrichment of genome-wide significant Alzheimer's disease loci across enhancers from Roadmap Epigenomics tissues ([@bib16]).**DOI:** [http://dx.doi.org/10.7554/eLife.10557.012](10.7554/eLife.10557.012)

Whether the enrichment of SNPs in the sub-threshold significance range represents linkage disequilibrium with existing above-threshold GWAS SNPs or novel biologically relevant loci remains an unresolved question ([@bib27]). In fact, an enrichment analysis using only SNPs nearby above-threshold GWAS loci produced a strong enrichment signature in the sub-threshold significance range ([Figure 3---figure supplement 2](#fig3s2){ref-type="fig"}). To distinguish between the two possibilities, we took a conservative approach and removed all SNPs within 1Mb of the initial 112 QT/QRS loci. Remarkably, the enrichment for LV enhancers persists and increases in the sub-threshold range (i.e. p=1x10^-4^ to 5x10^-8^, [Figure 3b](#fig3){ref-type="fig"}), likely due to removal of nominally significant SNPs6 where our results from [Figures 4](#fig4){ref-type="fig"} and [5](#fig5){ref-type="fig"} suggest that sub-threshold SNPs disrupt enhancer activity and therefore expression of a gene involved in cardiac electrophysiology. We set out to investigate whether this locus can serve as an example for future investigations of other sub-threshold loci.10.7554/eLife.10557.017Figure 5.Epigenomic prioritization distinguishes biologically relevant sub-threshold loci(**a**) *Left,* Sub-threshold loci overlapping enhancers have significantly stronger association signals than loci outside enhancers in the QT interval GWAS. *Middle*, Loci overlapping enhancers have significantly more likely to be newly genome-wide significant in the held-out QT interval GWAS, than loci outside enhancers. *Right,* Sub-threshold loci overlapping enhancers are significantly more likely to be nominally significant (p\<0.05) in QRS GWAS than sub-threshold loci not overlapping enhancers. (**b**) Genetic perturbation of genes with predicted links to 60


the rs1743292 or rs1772203 enhancers. We observed that both enhancers form interactions with promoters of the upstream popeye-domain containing (POPDC) family members *BVES/POPDC1* and *POPDC3,* and with predicted enhancers situated within introns of the downstream *PREP* gene ([Figure 6a,g](#fig6){ref-type="fig"}). This suggests that both enhancers may contribute to regulating the gene expression of *BVES* and *POPDC3*, of note because the POPDC protein family of transmembrane proteins has recently reported roles in cardiac pacemaking ([@bib14]; [@bib23]).

We sought to investigate the roles of the three candidate target genes (*BVES, POPDC3, PREP*) of the rs1743292/rs1772203 locus in regulating myocardial repolarization. Consistent with the genetic association between this locus and QT interval length, we found that mice homozygous for loss-of-function copies of *BVES* exhibit cardiac conduction and pacemaker defects ([Figure 6h](#fig6){ref-type="fig"}) ([@bib6]; [@bib14]).In contrast, *POPDC3* and *PREP* mouse loss-of-function models have no reported cardiac abnormalities, and instead show altered body fat, suggesting that this genetic locus alters QT interval length through the *BVES* gene ([@bib6]).

Strengthening our evidence implicating *BVES* in QT interval, we observed that across 59 human tissues, *BVES* is most highly expressed in human left ventricle, whereas *POPDC3* has much lower expression in cardiac tissue than skeletal muscle, and *PREP* is constitutively expressed across a wide range of tissues ([Figure 6---figure supplement 1](#fig6s1){ref-type="fig"}). We also used antisense morpholino oligonucleotides to knockdown transcripts from the *BVES, POPDC3* and *PREP* orthologs in zebrafish, observing that *bves* knockdown leads to a reproducible shortening of the zebrafish ventricular action potential duration (APD), the cellular correlate of the QT interval, (p=0.002 and 0.09


no: GSE53567).

The following previously published dataset was used:

Roadmap Epigenomics Consortium,2015,Enhancer maps, RNA-seq, CpG methylation datasets,<http://egg2.wustl.edu/roadmap/web_portal/>,Publicly available. Release 9

10.7554/eLife.10557.030

Decision letter

McVean

Gilean

Reviewing editor

Oxford University

,

United Kingdom

In the interests of transparency, eLife includes the editorial decision letter and accompanying author responses. A lightly edited version of the letter sent to the authors after peer review is shown, indicating the most substantive concerns; minor comments are not usually included.

Thank you for submitting your work entitled \"Discovery and validation of sub-threshold GWAS loci using epigenomic signatures\" for consideration by *eLife*. Your article has been favorably evaluated by Stylianos Antonarakis (Senior editor) and three reviewers, one of whom is a member of our Board of Reviewing Editors.

The reviewers have discussed the reviews with one another and the Reviewing editor has drafted this decision to help youregions. Why were these not considered? We need to see a fine-mapping analysis of the signal with imputation (which is valid even though the region is not GWS) prior to focusing on the particular SNP.

6\) In the morpholino experiments, there is apparently a lot of noise -- such that the differences between those loci classed as positive and negative look relatively small. Additional replicates are needed to be convincing here.

7\) There has to be a more up-to-date discussion of the relevant literature around biological signal lying in sub-GWS loci.

We appreciate that a lot is being asked for here and you may feel that such extensive revision is not feasible. One possibility is to remove some elements of the paper -- e.g. the morpholino work -- and focus on


aforementioned subsection, both the rs1743292/rs112332323 enhancer and the rs1772203 enhancer show allele-specific enhancer activity, and both enhancers form detectable 3D interactions with the *BVES* and *POPDC3* promoters ([Figure 6A, C, E](#fig6){ref-type="fig"}, Gg).

Thus, we now believe that genetic variation in the rs1743292 locus affects both enhancers, and that rs1772203 is an additional potential causal SNP that contributes to the activity of this locus.

*6) In the morpholino experiments, there is apparently a lot of noise -- such that the differences between those loci classed as positive and negative look relatively small. Additional replicates are needed to be convincing here.* We thank the reviewers for the suggestion. It was not feasible for us to perform additional morpholino experiments in the time frame, so we followed the editors' suggestion below and moved        /*!< SRAM2 busy by erase operation */

/**
  * @}
  */

/** @defgroup SYSCFG_FastModePlus_GPIO Fast-mode Plus on GPIO
  * @{
  */

/** @brief  Fast-mode Plus driving capability on a specific GPIO
  */
#define SYSCFG_FASTMODEPLUS_PB6         SYSCFG_CFGR1_I2C_PB6_FMP        /*!< Enable Fast-mode Plus on PB6 */
#define SYSCFG_FASTMODEPLUS_PB7         SYSCFG_CFGR1_I2C_PB7_FMP        /*!< Enable Fast-mode Plus on PB7 */
#define SYSCFG_FASTMODEPLUS_PB8         SYSCFG_CFGR1_I2C_PB8_FMP        /*!< Enable Fast-mode Plus on PB8 */
#define SYSCFG_FASTMODEPLUS_PB9         SYSCFG_CFGR1_I2C_PB9_FMP


The conventional seawater flow-related structures are mostly upright structures, partly modified from a caisson, which do not allow easy access of people. Since the conventional revetment structures are constructed by setting up a sloping mound as foundation, a large volume of rubble is required. Besides, the seawater flow structure does not adequately cope with the change of seawater level. Seawater from the open sea needs to be flown in at all levels, from the bottom to the top, so that the seawater can be fully circulated. However, in most of the conventional revetment structures, the seawater flows in only at a fixed depth, which restricts circulation of the seawater in the inland sea and makes water quality improvement difficult.
Because the conventional structures are mainly based on the conceptthan half the price of the crappy hotels and and were no comparison in price to the four star resorts. The bonus tip is to do your research and read through the reviews of previous guest to help alleviate any concerns or fears of staying with a stranger.

Do your homework – Make sure you research the location you are going to. Find out the currency, power sources, excursions, proximity of where you are staying to airport and local events. You don’t have to plan out your whole trip, but make sure you get the most out of it. Also reach out to friends or colleagues who have traveled to your selected destination and get their 1st hand experience and lay of the land. For example, I am a


Introduction {#sec1_1}
============

Visual information transferred to the brain via the optic nerve mainly occurs through two distinct yet complementary pathways \[[@B1],[@B2],[@B3]\]. The majority of retinal axons terminate in the lateral geniculate nucleus, which relays information to the primary visual cortex (geniculate system); however, a second pathway allows some crude visual information to be transmitted to the cortex via the superior colliculus and pulvinar nucleus even when the optic radiation has been damaged (nongeniculate system). Damage to this latter pathway has been observed to result in both attentional/spatial deficits and neglect syndromes \[[@B4],[@B5]\].

Research involving both macaque monkeys and healthy humans has revealed that the pulvinar is involved in perceptual awareness and cognitive processing of optical illusions \[[@B6],[@B7]\]. Further, autopsy results have revealed that the nongeniculate system is more severely affectedolder than those without, and pulvinar regions in patients with visual hallucinations were more frequently visible compared to patients with no history of visual hallucinations. No significant relationship was observed between whole brain atrophy as measured by Evans index and pulvinar visualization.

A previous study using single photon emission computed tomography reported that administration of donepezil hydrochloride alleviates visual hallucinations and increases cerebral blood flow in the occipital lobe \[[@B16]\]. However, a similar study utilizing positron emission tomography reported that the alleviation of visual hallucinations following the administration of donepezil hydrochloride is associated with decreases in occipital lobe metabolism \[[@B17]\]. Although the reason for such inconsistencies remains to be clarified, evidence still suggests that metabolic abnormalities in the occipital lobe may induce visual hallucinations in patients with DLB. The


Deep Brain Stimulation

Deep brain stimulation (DBS) is a surgical procedure used to treat a variety of disabling neurological symptoms—most commonly the debilitating symptoms of Parkinson’s disease (PD), such as tremor, rigidity, stiffness, slowed movement, and walking problems. The procedure is also used to treat essential tremor, a common neurological movement disorder. At present, the procedure is used only for patients whose symptoms cannot be adequately controlled with medications.

Deep brain stimulation, or DBS, uses tiny electrodes surgically implanted into part of the brain. The electrodes are connected by a wire under the skin to a small electrical device called a pulse generator that is implanted in the chest beneath the collarbone. The pulse generator and electrodes painlessly stimulate the brain in a way that helps to stop many ofthe symptoms of PD. DBS is stereotactic surgery, meaning it uses a 3D coordinate mapping system to locate tiny areas in our bodies in order to perform surgery accurately.

DBS usually reduces the need for levodopa and related drugs, which in turn decreases dyskinesias. It also helps to relieve on-off fluctuation of symptoms. People who initially responded well to treatment with levodopa tend to respond well to DBS. While the benefits of DBS can be substantial, it usually does not help with speech problems, “freezing,” posture, balance, anxiety, depression, or dementia.

DBS is not a good solution for everyone. It is generally used only in people with advanced, levodopa-responsive Parkinsons Disease who have developed dyskinesias or other disabling “off” symptoms despite drug therapy.

Deep Brain Stimulation surgery may be performed on


iMakeupArtist: Eyes

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Demonstrations include classic smoky eye, eyeliner basics, cat eyeliner, the best eye makeup for blue, brown or green eyes, simple everyday looks, and how to use black and white eyeliner. Learn dramatic techniques such as deep purple shadow, gold and copper royal blue shadow and navy blue smokey eyes. NowQ:

Creating 8 bit bitmap from array of numbers

This has been bugging me for some time, I want to make sure that my understanding of bitmaps is correct and get some help spotting errors. Basically what I am trying to do is to save an 8 bit bitmap file and at the same time display it in a picture box in the MFC application. I want to avoid the cumbersome method of saving the bitmap then loading it up again.
The saving file operation was mostly successful, however I altered my code and now what used to be white in the file (in this instance its a black and white image) is coming out usually green but it changes. I'm guessing this is because my data is referencing information in


The manometric evaluation of the rectosphincteric reflex in total colonic aganglionosis.
The manometric assessment of rectosphincteric function in 33 patients with histologically proven aganglionosis is reviewed. The age of the patient at first assessment and the presence of total colonic aganglionosis influenced the results obtained. Overall, a 67% accuracy rate was achieved at first assessment. This rate fell to 43% when the test was carried out during the first 7 days of life. Six cases had total colonic aganglionosis. In only a single patient of this group was the first test result positive for aganglionosis. Attention is drawn to this finding.a man named Anthony Tanguma (the "TCT2" wiretap). After a confidential informant linked Delgadillo-Uribe to another man named Andres Ayon-Corrales, the DEA sought and obtained a third wiretap (the "TCT3" wiretap) on a cell phone allegedly used by Ayon-Corrales. The toll records for Ayon-Corrales' phones, in turn, revealed a fourth cell phone that was connected to Cecilio Garcia-Villalba ("Cecilio"), a brother of the defendant in this case.
Sensing they were about to break the conspiracy wide open, the DEA sought authorization for a fourth wiretap on Cecilio's phone (the "TCT4" wiretap). In support of the TCT4 application, Hackett submitted another affidavit, spanning thirty-one pages, which described the status of the investigation and explained the need for a wiretap. The district court approved the TCT4 wiretap, which generated information linking


F.3d at 899 (emphasis added). Like the affidavit at issue in Rivera, "the affidavit here did more than recite the inherent limitations of using confidential informants; it explained in reasonable detail why each confidential source or source of information was unable or unlikely to succeed in achieving the goals of the ... investigation." Id.
We recognize that some language in the affidavit may be conclusory or merely describe the inherent limitations of certain investigatory techniques, but this is not decisive. See United States v. Torres, 908 F.2d 1417, 1423 (9th Cir.1990) ("The presence of conclusory language in the affidavit will not negate a finding of necessity if the affidavit, as a whole, alleges sufficient facts demonstrating necessity."); see also United States v. Fernandez, 388 F.3d 1199, 1237 (9th Cir.2004).The affidavit as a whole speaks in case-specific language, and we are persuaded that it contains "a full and complete statement as to whether or not investigative procedures have been tried and failed or why they reasonably appear to be unlikely to succeed if tried or to be too dangerous." 18 U.S.C. § 2518(1)(c).

2
Satisfied that Hackett's affidavit is sufficiently detailed, we turn to whether the issuing judge abused his discretion in finding that the TCT4 wiretap was necessary. Employing "a `common sense' approach," we must "evaluate the reasonableness of the government's good faith efforts to use traditional investigative tactics or its decision to forego such tactics based on the unlikelihood of their success or the probable risk of danger involved with their use." Gonzalez, Inc., 412 F.3d at


1112.
Our decision in McGuire guides us. There, FBI agents sought to wiretap phones used by the "Montana Freemen," a group of vigilantes bent on taking down the United States government. McGuire, 307 F.3d at 1195. In upholding the wiretap, we emphasized that "the government is entitled to more leeway in its investigative methods when it pursues a conspiracy." Id. at 1198. "Like the Hydra of Greek mythology," we reasoned, "the conspiracy may survive the destruction of its parts unless the conspiracy is completely destroyed." Id. at 1197-98. Noting that "[i]t is one of the first duties of every government to extirpate gangs of thieves," id. at 1198 n. 3 (quoting 4 Thomas Babington Macaulay, History of England 205 (1855)), we upheld the district court's approval of the wiretapthe wiretap was necessary.

3
Before concluding our discussion of the wiretap, we pause to address Armando's general objection to the affidavit: that it improperly employed a "cascading theory of necessity." According to Armando, "with each wiretap order obtained and employed successfully during the investigation, the need for the next wiretap more and more was presumed and other investigative methods more and more were discounted as inconvenient or inefficient." Armando asserts that by "the time of the application for a wiretap on TCT4, the allegations of necessity had become largely conclusory statements that improperly attempted to fold the showing of necessity to wiretap TCT1 into the application to wiretap TCT4."
Because our precedent is not clear on what constitutes a "cascading theory of necessity," we take this opportunity to clarify our


long as they bear on whether the government has adequately shown necessity within the current application. If these facts are incorporated into the latest affidavit, the issuing judge may examine them. For example, the government may rely on past failed attempts to infiltrate an organization, detailed in past affidavits, as evidence that future attempts would be fruitless. Nothing in our precedent prohibits an affidavit from employing such a technique, which is designed merely to save time, not to piggyback an earlier showing of necessity into a later affidavit. The key question will always be whether the wiretap application separately satisfies the necessity requirement.
Here, the TCT4 application separately satisfied the requirement. The government used the pen register and trap-and-trace device on Cecilio's cell phone, not merely on the cell1149, 1153 (9th Cir.2007) (upholding a search when "the affidavit rested primarily on the police officers' own observation of the controlled drug transaction between Hollis and the witness and the surveillance of Hollis's subsequent movements, which led to the North Hoyt apartment"); Fernandez, 388 F.3d at 1254 ("Agent Spencer's statements about the likelihood that the Rambler residence contained contraband or evidence relevant to the crimes charged, which were based on his own professional experience of the Mexican Mafia, combined with the information from the wiretaps, were sufficient to give the magistrate judge a substantial basis to conclude that the items sought were at the residence.").
Because we are convinced that the district court erred in finding that the warrant was not supported by probable cause, we do not address