"Last time I played this game, it ruined my life." "It ruined your life?" ""In the jungle you must wait, till the dice read five or eight."" "I was a little girl, Alan." "You disappeared." "And a bunch of bats surrounded me and chased me down the street." "I was afraid." "I'm sorry, Alan." "No one believed me." "I was all alone." "So was I." "For 26 years, Sarah." "Me too." "It's okay, Sarah." "We're scared too." "But if we finish the game, it'll all go away." " What if I get stuck in the game?" " You won't." "Because I won't stop playing." " And neither will I." " I won't either." " Come on, Sarah." " Please?" "I knew this was gonna be a bad day."it?" " It's my turn." " Really?" "Great." "You might have told us there was a man in there with a rifle that hunts people." "I didn't know, okay?" "It's just the roll of the dice." "Is he the reason you didn't wanna play?" "You didn't wanna play either..." "Mr. We-Started-Something-26-Years-Ago- And-Now-We-Gotta-Finish-It?" " What's the deal with you and this guy?" " He's a hunter." "He kills things." "Right now, he wants to hunt me and kill me." " Why you?" " Why me?" "I don't know." "Everything about me he finds offensive." "You think it'd be a waste of his time." " Maybe he needs something for his wall." " It's your turn." "You ever thought about sitting down and talking about your differences?" "What, are you


no warrant requirement in place for the Oakland Police Department at that time. That doesn't mean the court won't find that the use of a Stingray device (or, in this case, two of them) requires the use of a warrant, but even if it does, the good faith exception is likely to apply -- especially in the FBI's case, as its warrant requirement was still thee years away. In both deployments, pen register orders were used to obtain subscriber info. Because exigent circumstances dictated the requests, no judicial approval of the orders was needed.

Ellis' lawyers are hoping the judge will find the circumstances surrounding the Stingray deployments to be not nearly as "exigent" as the government claims.

Prosecutors argued that because the three men involved in the altercation wereThe FBI's newer version had no such problems. The Oakland PD spent ten futile hours searching for Ellis. The FBI located him roughly an hour after deploying its Stingray. It also deployed something else along with it. From the FBI's declaration:

At one point, in an effort to reduce the error radius and increase the accuracy of the location of the cellular telephone, a cell site simulator augmentation device was deployed into the interior of the apartment building. This device is used in conjunction with the cell site simulator and has no data storage capability whatsoever.

Farivar spoke to Daniel Rigmaiden -- the person who first uncovered government use of Stingray devices in criminal investigations (prior to that, it had only been deployed in war zones by the military) while


and solve problems along the way. PCCY’s recommendation is to act on two fronts: building up the infrastructure of online learning and simultaneously solving for the academic and equity issues by convening experts and contractors.

The two things should happen at once, she said, and should happen fast, if they’re not happening already. “They don’t have to happen sequentially,” said Cooper.

English learners, special education, and other subgroups need quick action from such groups of experts, and only the District can bring them together.

“All the people who do this work need to develop a plan,” she said.

Philadelphia is already slow off the mark, she said. “We’ve been out since March 13 – I don’t know why it hasn’t happened before,” she said.

Districts with wide disparities

By tying “good faith” to thea plan.”

But whether or when they take the next step – putting in place conditions under which all districts can offer full online programs with trained teachers and students held accountable for their work – is still up in the air.

Rivera also said Wednesday that no matter how long schools are closed as a result of the COVID-19 crisis, the academic year cannot be extended beyond June. That is when the fiscal year ends, he said.

“By statute, we cannot extend school past June 30,” Rivera said in a conference call with reporters.

Right now, schools are officially closed through April 6. Spring break in Philadelphia and some other districts is scheduled for the following week, which includes both the start of Passover and Good Friday.

– With Lynn Oseguera


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   GTA was negative. Skin testing to OPA resulted in immediate wheal and flare reactions in all 4 patients within 20 minutes and late reactions at 24 hours but negative reactions in controls. Subsequent to the testing, 3 of the patients returned for repeat cystoscopy in which GTA but not OPA was used to disinfect the cystoscopes and tolerated the procedure. OPA solution should be considered a cause of anaphylactic/allergic reactions following cystoscopy and possibly following instrumentation with other medical devices disinfected by this material.


manage to save all of their receipts for tax purposes or those who get up and make their beds every single day or remember to get their dogs vaccinated every year?

These extreme humans used to represent for me the unattainable. I used to read about them in magazines that I'd skim through at the checkout line at Walmart. I used to hate those people. And I would have gone on hating them had I not been made aware of the underreported epidemic of severely overweight religious devotees across some swath of Asia or Africa. Now, I just feel bad for them all.

I am almost tempted to start an FMS awareness campaign, but that sounds like an awful lot of work.A novel heat shock protein plays an important role in thermal stress management in cyanobacteria.
A novel heat shock gene, orf7.5, which encodes a putative acidic polypeptide of 63 amino acids, was cloned from the cyanobacterium Synechococcus sp. PCC 7942. Northern blot analysis revealed the presence of 400- and 330-base orf7.5 mRNAs, which were barely detectable in the cells grown at 30 degrees C but increased transiently in response to heat shock at 40 or 45 degrees C. Primer extension analysis showed that the two mRNAs have different 5'-ends. Chloramphenicol enhanced the accumulation of the orf7.5 mRNA, whereas it inhibited the increase in the amount of the groESL mRNA. To reveal the role of the orf7.5 gene in thermal stress management, we constructed a stable mutant in which a


while in a Chinese HF cattle population, associations with bTB susceptibility/resistance were found with SNPs in exon 11 and introns 5 and 9 ([@B26]). Additionally polymorphisms in the 3′UTR of the bovine *SLC11A1* gene, that have been shown to cause changes to the lengths of two microsatellites (MS1 and MS2), have been identified in various breeds of cattle ([@B32]; [@B43]; [@B21]). Interestingly, an increase in the length of the MS1 microsatellite has been described to reduce traits indicative of bTB infection in African zebu cattle ([@B23]). In contrast, no association between the MS1 microsatellite and response to the tuberculin skin test was found in a study performed using HF and Jersey cattle in Argentina ([@B22]). Furthermore, no associations between the MS2 microsatellite and susceptibility/resistance to bTB have currentlyfor 20 s and 72°C for 15 s, respectively. The PCR products generated were separated by agarose gel electrophoresis, purified using the QIAquick Gel Extraction Kit (Qiagen), and then submitted for sequencing (MRC PPU DNA Sequencing Service, Dundee University).

Single nucleotide polymorphisms were identified using CLC Main Workbench version 6.0.2 (CLCbio, Aarhus, Denmark). Allele and genotype frequencies were calculated for each SNP and compared between cattle breeds using a Fisher Exact Test^[3](#footnote3){ref-type="fn"}^. Phylogenetic analysis was performed in CLC Main Workbench using the coding region genotypes identified in the study and the bovine reference sequence^[4](#footnote4){ref-type="fn"}^. Heterozygous loci were labeled using IUPAC ambiguity codes. A maximum likelihood phylogenetic tree was constructed using a Jukes Cantor model and 100 bootstrap iterations.

Measurement of NRAMP1 Protein in Bovine Monocyte-Derived Macrophages by ELISA {#S2.SS3}
-----------------------------------------------------------------------------

Monocytes were


                   15 (100)    0          0          1
  rs109551090   SW             21 (70)                9 (30)      **0.0002**               8 (53.4)    5 (33.3)   2 (13.3)   **0.0038**
  SNP4          BS By James Sweet | USA

BRICS, an association between Brazil, Russia, India, China, and South Africa, is considering starting a gold trade between members of the association, which can threaten American dominance in the world economy. If BRICS began an internal gold trade, it is entirely possible, and plausible, that the nations involved with the trade could back their currencies with a gold standard, effectively taking the US Dollar out of dominance. Is this the beginning of the end of American dominance?

Russia and China, arguably the most powerful nations in BRICS, have been importing and producing gold in great amounts. In 2016, China was ranked as the second largest importer of gold, according to the Observatory of Economic Complexity. In 2017, China was ranked as the largest producer of


investigated five key topic areas stemming from the literature review on vulnerable road users including hazard perception, risk perception, emotion, attitudes to sharing the road and empathy. It was found that drivers and horse riders are not always aware of the same hazards in the road and that this may lead drivers to under-estimate the risk when encountering horses. Drivers often had good intentions to overtake horses safely, but were unaware of how vulnerable passing very wide and slow made them feel until they had begun the manoeuvre and hence quickly reduced such feelings either by speeding up or cutting in too soon. However, other than this, drivers had good skills when encountering horses. But these skills could be impeded by frustration when encountering a slow moving horseis that if the current path between the track battery and the track relay is opened, the track relay will not be energized. Common causes of track circuit failure with typical railroad fail-safe circuits that may interrupt the current path include broken rail, broken wire connections between the battery or relay and the rail, broken rail joint electrical bonds, and failed battery power. Should any element of the circuit fail, the signal control element, typically the track relay, will revert to the safest condition, which is de-energized. The typical track circuit is also an example of railroad signal closed circuit design. All elements of the circuit are necessary and only one current path is available to energize the track relay.
The track battery/relay circuit is often the basic functional


a car: they protect the rider in the car, but anyone can freely choose not to use them. Certainly don't expect a person's seat belt to stop them from getting out of their car and attacking you (or accessing your Web service).
Suppose I write a program that accesses your Web service. It's just a program that sends TCP messages that include HTTP requests. You're asking for a server-side mechanism to distinguish between requests made by my program (which can send anything) and requests made by a browser that has a page loaded from a permitted origin. It simply can't be done; my program can always send a request identical to one formed by a Web page.
The same-origin policy was invented because it prevents code from one website fromaccessing credential-restricted content on another site. Ajax requests are by default sent with any auth cookies granted by the target site. For example, suppose I accidentally load http://evil.com/, which sends a request for http://mail.google.com/. If the SOP were not in place, and I was signed into Gmail, the script at evil.com could see my inbox. If the site at evil.com wants to load mail.google.com without my cookies, it can just use a proxy server; the public contents of mail.google.com are not a secret (but the contents of mail.google.com when accessed with my cookies are a secret).

A:

The same-origin policy is enforced on the client-side. If the browser supports CORS, the server can send back headers that tell the browser to make exceptions to the same-origin policy. For example, sending


the header
 Access-Control-Allow-Origin: www.example.com

would tell the browser to allow cross-origin requests from www.example.com.
 Access-Control-Allow-Origin: *

tells the browser to allow all cross-origin requests to that resource.

A:

Web servers generally prevent attacks of this sort by checking the (infamously misspelled) Referer line in the HTTP header, to ensure that a request is coming from a page on their own site.  There's no good way to guard against a malicious client, but that's not how XSRF attacks work.
The client isn't malicious; it's generally an ordinary user who's been tricked by a malicious third-party into opening a document that silently makes a HTTP request using the client's stored cookies.  So if the server can verify via the Referer that the HTTP request is coming from gmail.com, and not MyAwesomeWebsite.com, it can1. Field of the Invention
The present invention relates to a telephone system and method for using time information transmitted at the beginning of phone calls to update the system time of a phone, other clocks, and computer systems.
2. Description of the Related Art
Telephone subscribers communicate via a vast telephone network, referred to as the Public Switched Telephone Network (PSTN). In the present disclosure, the term "PSTN" is intended to include the analog telephone network or POTS (Plain Old Telephone Service), ISDN (Integrated Services Digital Network), DSL (Digital Subscriber Line), and Wireless Local Loop (WLL), among others.
A telephone subscriber's communications devices, e.g., telephones, are typically connected in parallel to a telephone line which links a subscriber's premises to a telephone service provider's central office. An ordinary telephone is the


the first matching the maximum performance as with iOS 10.2, but the following four at relatively set intervals showing steps downwards in performance.

The same was seen with tests run on the iPhone 6S running iOS 11.2, which was released in December 2017.

Poole wrote: “The distribution of iPhone 6S scores for iOS 10.2.0 appears unimodal with a peak around the average score. However, the distribution of iPhone 6S scores for iOS 10.2.1 appears multimodal, with one large peak around the average and several smaller peaks around lower scores. Under iOS 11.2.0 the effect is even more pronounced.”

The results for the iPhone 7 show a similar pattern. With iOS 10.2, 10.2.1 and 11.1.2, the iPhone 7 results show one large peak at the average maximum performance expected of the smartphone.But iPhone 7s running iOS 11.2 then show one maximum peak followed by three smaller peaks.

“The distribution of iPhone 7 scores under iOS 10.2.0, iOS 10.2.1, and iOS 11.1.2 appears identical. However, the distribution changes with iOS 11.2.0 and starts to look like the iPhone 6S distribution from 10.2.1,” wrote Poole.

According to Reddit users, who first reported the problem, the reason for the performance differences is due to degrading batteries. As a smartphone ages, as does the battery inside.

Most modern lithium-ion batteries inside smartphones are designed to last at least 500 full charge and discharge cycles, which works out to around two years of typical smartphone use.

However, the shorter the battery life and the more a user has to charge it, such as topping up during the day


Reed A, Pigage JC, Pigage HK, Glickman C, Bono JM. Comparative analysis of microbiota along the length of the gastrointestinal tract of two tree squirrel species (*Sciurus aberti* and *S. niger*) living in sympatry. Ecol Evol. 2019;9:13344--13358. 10.1002/ece3.5789

1. INTRODUCTION {#ece35789-sec-0001}
===============

Animals harbor complex communities of microorganisms within their gastrointestinal (GI) tracts. These communities have an important impact on their host through influences on essential processes, such as nutrient acquisition, immunity, development, and behavior (Lathrop et al., [2011](#ece35789-bib-0035){ref-type="ref"}; Ley, Lozupone, Hamady, Knight, & Gordon, [2008](#ece35789-bib-0040){ref-type="ref"}; Sommer & Bäckhed, [2013](#ece35789-bib-0060){ref-type="ref"}; Tremaroli & Bäckhed, [2012](#ece35789-bib-0063){ref-type="ref"}). Comparative studies within and between species have revealed considerable variation in the microbiome, and understanding the factors that contribute to this variation is important for understanding how these communities influence host ecology and evolution (Ley, Lozupone, etfrom the upper and lower GI tract were also reinforced by the results of differential abundance analyses, which identified differentially abundant facultative anaerobes in the upper GI tract samples and mostly fermentative polysaccharide‐degrading anaerobes in the lower GI tract of both species.

Despite living in the same habitat, comparisons between fox and Abert\'s squirrels revealed considerable divergence in their microbiota. Abert\'s squirrels have an unusual diet that is high in fiber (Keith, [1965](#ece35789-bib-0027){ref-type="ref"}; Snyder, [1992](#ece35789-bib-0059){ref-type="ref"}; States & Wettstein, [1998](#ece35789-bib-0061){ref-type="ref"}). This diet has likely shaped the evolution of the Abert\'s squirrel GI tract, as evidenced by morphological adaptations, particularly in the lower GI tract, that increase the surface area for nutrient absorption and decrease transit time (Murphy & Linhart, [1999](#ece35789-bib-0051){ref-type="ref"}). Consistent with these observations, the microbial communities of the fox


after eclosion using a Geneswitch Tubulin-GAL4 driver by addition of RU-486 to the fly food. We observed no significant impact of intronic repeat expression on viability (Fig. [1](#Fig1){ref-type="fig"}h).

The role of repeat location in GGGGCC toxicity {#Sec20}
----------------------------------------------

To determine if the repeat location within a transcript might impact its toxicity, we inserted the same 28 G~4~C~2~ repeat cassette used to generate the intronic repeats into the 5′ leader of GFP rather than an intron (Fig. [2](#Fig2){ref-type="fig"}a). No start codons were present between the transcription start site and the repeat, although the ATG of GFP was retained 3′ to the repeat. We introduced small frameshift mutations between the repeat and the open reading frame of GFP so that it acted as a reporter for RAN translation in the 0+ (GA), 1+ (GP),immunofluorescence (left) and the percentile of cells with significant nuclear accumulation of GA DPR staining for the indicated genotypes (right). **c** Representative Immunofluorescence images of *Drosophila* retinal sections probed with antibodies against the GP dipeptide repeats. **d** Quantification of total GP repeat staining by immunofluorescence (left) and the percentile of cells with significant nuclear accumulation of GP DPR staining for the indicated genotypes (right). E) Representative Immunofluorescence image of transverse retinal sections from *Drosophila* of the indicated genotypes probed with antibody against GR dipeptide repeats. F) Quantification of total GR repeat staining by immunofluorescence (left) and the percentile of cells with significant nuclear accumulation of GR DPR staining for the indicated genotypes. Graphs represent means ± SEM. \* p \< 0.05; \*\* p \< 0.01 by Kruskal-Wallis after Dunn's correction for multiple


G~4~C~2~ repeat with the native C-terminal sequence showed increased toxicity with an increasing repeat size (Fig. [5](#Fig5){ref-type="fig"}b, solid green vs solid blue line). However, when the native C-termini were removed and replaced with short C-termini, toxicity was significantly increased (Fig. [5](#Fig5){ref-type="fig"}b, dashed lines vs solid lines). These (G~4~C~2~)~69~ repeats with the native C-termini (CT) or with short C-termini (ΔCT) were also introduced to the same locus (AttP40) in *Drosophila* using pUAST-AttB vectors to achieve equal expression levels. Consistent to the partially protective effects found in the culture neurons, the inclusion of the native C-termini partially suppressed the repeat-associated toxicity when these constructs were expressed in the fly eyes (Fig. [5](#Fig5){ref-type="fig"}c).

In an attempt to determine which C-terminal reading frame was most critical for toxicity, we introduced a series ofrepeat while maintaining the native C-terminal sequence across all 3 reading frames. Bottom: Survival of neurons expressing the indicated constructs as measured by cumulative risk of death. **b** Schematic of constructs used in panels **c**-**e**. **c** Cumulative risk of death of neurons transfected with constructs containing an AUG codon in the GA reading frame with or without the native C-terminus. **d**) Cumulative risk of death of neurons transfected with constructs containing an AUG codon in the GP reading frame with or without the native C-terminus. **e** Cumulative risk of death of neurons transfected with constructs containing an AUG codon in the GR reading frame with or without the native C-terminus. \*p \< 0.05 and \*\* p \< 0.01 indicate a difference in survival as determined by Cox proportional hazard analysis. The number


The arrival of her daughter brought divorce for netball champion Shumaila Javed.

Highlights Uttar Pradesh's resident Shyumla Javed divorced over phone

Shyumla now wants Chief Minister Adityanath to look into the matter

Mediums used for triple talaq by Muslim men has sparked a debate

Amroha: Shyumla Javed,national netball champion says her husband gave #TripleTalaq after she gave birth to a girl pic.twitter.com/odiIHmZvQs ANI UP (@ANINewsUP) April 23, 2017

Her husband said the word 'talaq' thrice on phone to divorce national-level netball player Shumaila Javed in Yogi Adityanath's Uttar Pradesh, reports news agency ANI. Her fault? She gave birth to a girl. Ms Javed from Amroha, about 380 km from Lucknow, is currently staying at her parental home and wants Chief Minister Adityanath to look into the matter. In another case from Agra, aof 2743 and 12389.
13
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14
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99
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185
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4
What is the greatest common factor of 33423 and 897?
39
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18
Calculate the highest common factor of 909592 and 40.
8
What is the greatest common divisor of 8528 and 6656?
208
Calculate the greatest common factor of 7680 and 1824.
96
What is the highest common divisor of 143 and 159341?
13
Calculate the highest common factor of 902 and 15416.
82
Calculate the highest common factor of 588 and 696.
12
Calculate the highest common factor of 64 and 444024.
8
Calculate the greatest common divisor of 38907 and 495.
99
Calculate the highest common factor of 7 and


919744.
7
What is the highest common factor of 34272 and 987?
21
What is the highest common divisor of 1454664 and 8?
8
Calculate the greatest common divisor of 80 and 10272.
16
Calculate the greatest common divisor of 1290 and 46698.
258
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29
What is the greatest common divisor of 753 and 8255139?
753
What is the highest commothe area in which data (optional event) such as index information, TOC, and the like is recorded.
In U.S. Pat. Nos. 4,338,644 and 4,383,285 are disclosed that a memory loaded in a recording medium cassette of a VCR stores reacording data, and in Japanese Patent Application number H04-217503 and corresponding to EP Application number 0,580,434, are disclosed such recording medium cassette. Each of the above application are owned by the assignee of the present invention and are hereby incorporated by reference.
The character information regarding the recorded video image is recorded into a text event existing in the memory. In the case where there is the character information, a text flag provided in the memory is set to "0". In the case where there is no character information, the text


World War II, when it was a new training ground for soldiers in the 1940s.
But times have changed since these veterans slept in the barracks more than 50 years ago.
"I don't even know where I am," said John Hudnall, 75, of Shelby County, Ky. "All the buildings are gone."
The camp is also missing a lot of mud. Nick Francullo of Lynn, Mass., said the camp used to be known as Camp Mudbury because when he was there it was just being
sodded. There's also no more potbellied stoves sitting in the hallways.
"Everything is more up to date," Francullo said. "We used to have to start a fire outside, and detail was the coal bin."

While the camp might look different, the veterans were still able to keep their comradeship andfor its characteristic swiftness in battle - and inscribed with a message saluting the "real heroes" of the war was hung at the chapel's entrance.
Over a balcony, members hung a black and gold banner hand quilted by Mary Belle Wright in memory of her husband John, a member of the 83rd Division, who died several years ago.
The banner displays five gold stars, one for each of the five battles fought by the 83rd, and an inverted triangle enclosing interior circles and lines forming the word Ohio.

About 80 percent of the division's first members originated from that state
Columbus resident Ames Miller, chairman of the division association, said the gathering carried special meaning for the group, which meets annually in different U.S. cities.
"We're honoring the people who didn't come home


on their morning draws.

The Voice of the Customer: The physicians’ expectation was that test results from the morning, be RN reviewed, and charted by 7:00 AM each morning.

The Current Situation: Specimen collection began at around 4:00 AM each morning and ended at ~7:00 AM at which time all the specimens that had been collected were receipt verified and deposited in the specimen processing areas of each lab section for processing and testing.

Kaizen Plan: Since the hospital had limited pneumatic tube capabilities, a milk run was planned to get the specimens to the lab for testing as soon as possible after the patient draw. (Eliminating the transportation, inventory, and overproduction waste the specimens were undergoing.) Staff schedules were changed accordingly and new assignments made to the process.

A centralized specimenMost of the time, I criticize the moves of the health administration or write about the scandals in the field, but rarely I discuss possible solutions for the catastrophic situation in the health care system. If at a conference or in a TV program I am asked about it, to save the time I stick to the political reality and claim that I see no solutions since, without nitpicking, I cannot name a single one among the Croatian politicians who could make some serious changes in the system. All our politicians dealing with health care have either already had their turn in the governing position in health care, have not shown enough competence or interest in the health care issues, or are themselves part of the dysfunctional health


is similarly reduced in HD and peritoneal dialysis (PD) patients \[[@B15-nutrients-09-00548],[@B18-nutrients-09-00548]\]. However, when inflammation is added, it gets worse. Inflammatory episodes are more frequent with HD than they are with PD \[[@B15-nutrients-09-00548]\].

3. Triglycerides and Hemodialysis {#sec3-nutrients-09-00548}
=================================

When malnutrition appears, an increase in protein and calories is often recommended to adjust for the lack of energy \[[@B6-nutrients-09-00548]\]. Fat contributes to 40% of calories, which derive mainly from triglycerides (TrG) \[[@B19-nutrients-09-00548]\]. Triglycerides are transported in blood in the core of lipoproteins (chylomicrons and VLDL). Fatty acids (5% by glycerol) contribute to 95% of that energy content. Lipoprotein lipase (LPL) and hepatic lipase (HL) are key enzymes in the breakdown of triglycerides \[[@B20-nutrients-09-00548],[@B21-nutrients-09-00548],[@B22-nutrients-09-00548]\].

Hyperlipidemia, especially the increase of TrG in all density classes, is present in patients with severe CKD and those onelevated in HD patients \[[@B31-nutrients-09-00548]\], ANGPTL3 and ANGPTL4 are significantly increased \[[@B29-nutrients-09-00548],[@B32-nutrients-09-00548]\]. Hemodialysis did not eliminate ANGPTL3, while a high flux dialysis filter is necessary to cause a reduction in ANGPTL4 levels \[[@B29-nutrients-09-00548]\]. Besides inhibiting factors to LPL, HD patients have only approximately half of the body store of lipases compared with healthy age-matched persons \[[@B33-nutrients-09-00548]\]. The body store can be estimated by an intravenous bolus dose of heparin that releases most of the LPL and hepatic lipases from their binding sites \[[@B34-nutrients-09-00548]\]. A peak value of the lipase or area under the curve (AUC) can be used for a comparison between groups \[[@B33-nutrients-09-00548]\]. The reduction of LPL, upon heparin injection, results in a limitation of breakdown capacity of TrG into FFA and energy. In addition, during HD,


was interpreted by web sites such as Slashdot to mean that Windows 7 would not include MinWin.  Mark Russinovich suggested that some of the confusion surrounding MinWin may be related to the imprecise use of the word "kernel"; MinWin is not, in and of itself a kernel, but rather a set of components that includes both the Windows NT Executive and several other components that Russinovich has described as "Cutler's NT".

Windows Server 2016
In Windows Server 2016, Nano Server is an option with the 32-bit compatibility layer or graphics.

See also
 Architecture of Windows NT
 Windows Vista startup process
 Microkernel

References

Category:Windows NT architectureQ:

C# Windows Application - Many threads using the same connection?

I've got a c# WINDOWS Application that is multi-threaded. It is my understanding that in a web environment, connections are pooled automatically. It is also my understanding that in a Windows app, this is not the case. Therefore, for a Windows app, the same connection should be used and not closed after each call, but instead closed when the app shuts down.
I'm curious though - is my correct? If it is, can two threads use the same connection to get a dataset from the DB at the same time or is that functionality queued up?
Thanks

A:

The Connection Pooling is one feature of ADO.NET. Therefore the connections are already pooled. Not only in the web environment.
http://www.ondotnet.com/pub/a/dotnet/2004/02/09/connpool.html


Shares of Fitbit ended the day up more than 25 percent Thursday after the company beat estimates on earnings and revenue.

San Francisco-based Fitbit surpassed expectations for a 1-cent loss per share in the third quarter, reporting earnings of 4 cents per share. The wearables company beat on revenue as well, reporting $394 million for the quarter.

Also after the bell on Wednesday, Fitbit said its smartwatch sales grew significantly over the third quarter, making up 49 percent of total revenue, compared to under 10 percent less than a year ago.

"Fourteen months ago we had zero percent share" in smartwatches, Fitbit CEO James Park said on "Squawk Alley" on Thursday. "Now we're No. 2, beating the likes of Samsung."

The company expects unit shipments to grow year over year, Park said.

FitbitSaving in the Summer

Were in the peak of summer! If you have kids, they are out of school and complaining almost every day that they’re bored 🙂 So how can we entertain them without breaking the bank and still save; how can we enjoy ourselves without breaking the bank? There are a bunch of things to do like going to the park or chucky-cheeses (which for $10 in coins can keep them busy for a while). But there are some items which may be more expensive in the summer and that’s why it’s better to save and spend in the fall and winter months on these. Apart from these, I’ll talk about a couple of ways to enjoy those summer days and evenings without breaking the bank!

Purchases to


get….wait for it…free personalized advice!

Post navigation

4 thoughts on “Saving in the Summer”

I do love the fire pit idea. We have fires all the time. Just have to factor in the cost of wood. We usually have a few contacts though and we can find free or discounted wood. Or take people’s discarded or broken pallets to burn. Easy way to save a few bucks and just as fun as any other activity. Nice and relaxing.

Our house backs to the woods so there’s twigs and branches a plenty. Free wood 🙂
I’m looking to find a cheap fire pit now since it may cost less in the summer perhaps. It’s relaxing especially when friends are gathered around and share stories together.

Nice post SMM! Love the idea of trying to savestaff. This used to annoy the hell out of me, but now I get it. She does have the worst deal and, relatively, the man does have the easy part. I qualify this with the next point...

They didn't tell me about the pressure...

7. It gives you the ultimate performance anxiety

"You've got the easy job" – that's what I was always told by the clinic staff each of the three times we did IVF. Nip into a booth on the key egg collection day, do your business in a pot and that's that. But they didn't tell me about the pressure. Years of infertility and disappointment and the silent blame game now resting on a window of one hour in a booth. A non-soundproofed booth, I discovered, so I


to use. There is a slight reduction during the defrosting process but generally frozen is as good as fresh – 'like peas' as one consultant helpfully put it.

NetDoctor, part of the Hearst UK wellbeing network
Netdoctor participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites.different contaminants at the same time.

The scientists believe the particles wouldn’t post risks to humans or the larger environment, as the vaults are made from the proteins of living tissues and grown naturally in the cells of many species.


you think is best. In the nature of this process, you don't get everything, but hopefully you get a lot of it."

But Dayton's path forward is sure to test the political skills he has sharpened over the past year.

Backed by favorable poll ratings, the governor is pushing his agenda at a time when the GOP-led Legislature is still digging out from a scandal that toppled the party's former Senate majority leader late last year.

Yet, despite that seeming political advantage, Dayton also faces the recurring challenge of winning support from rank-and-file legislators within his own party -- including some who say he did a poor job of reaching out to them in the run-up to last year's historic, three-week state government shutdown. Several felt excluded, their years of hard-wonindicated by their crossing time, that is similar to unbound associations. The statistical analysis allowed us to separate the sample into two groups showing different clustering characteristics. However, they have the same dynamical evolution, since the whole sample has been revealed as expanding objects, for which the substructures seem to have not been erased. These results are in agreement with simulations that adopt low surface densities and models under supervirial conditions.'
author:
- |
    J. Gregorio-Hetem$^{1}$[^1], A. Hetem$^{2}$, T. Santos-Silva$^{1}$, B. Fernandes$^{1}$\
    $^{1}$Universidade de S[ã]{}o Paulo, IAG, Rua do Mat[ã]{}o 1226, 05508-900 S[ã]{}o Paulo, Brazil\
    $^{2}$UFABC Universidade Federal do ABC, CECS, Av. dos Estados, 5001, 09210-580 Santo Andr[é]{}, SP, Brazil
date: Accepted Received
title: Statistical fractal analysis of 25 young star clusters
---

\[firstpage\]

Open


a real sample (as those obtained by observations) and the standard deviation is calculated from these data.

In the present work, the bootstrapping algorithm was implemented as proposed by @press. The algorithm generates synthetic distributions of cluster members based on the original positions of the stars. A number of stars is moved from their original positions, being replaced by random points within a box, around the star, with side equals to the cluster radius. Then, the parameters $\overline{m}$, $\overline{s}$ and $\mathcal{Q}$ are calculated for each synthetic distribution. By adopting a fraction $f = 1/e \sim 37\%$ of replaced stars in a symmetric normal distribution, it was possible to derive $1\sigma$ deviation for $\mathcal{Q}$, $\overline{m}$ and $\overline{s}$.

![Distribution of $\mathcal{Q}$ as a function of number of stars (top axis) and membershipprobability (bottom axis) calculated for members and candidate members of NGC 2244. The limiting values adopted in the present work, $N=256$ and $P = 50\%$, are shown by a dashed line.[]{data-label="fig:qnp"}](fig_ppxQ.eps){width="6cm"}

Analysis of fractal statistics {#sect4}
==============================

Membership dependence {#sect41}
---------------------

In spite of the whole set of stars (candidates and members) had been used by SG12 to determine the cluster structural parameters, in the present work we preferred to constrain the statistical analysis to confirmed members only. Based on the probability membership ($P\%$), the stars were separated in two sub-samples: the very likely members of the cluster have $P \geq 50\%$ (denoted by $P_m$), while the candidate members (called $P_c$) have $P < 50\%$ .

Aiming to evaluate the effect on the fractal statistics by considering different numbers of stars and to explore the


to stress that this is not necessarily a clue for physical relation with the nearby cloud. The meaning of these clusters coinciding with the theoretically expected $\mathcal{Q} \times D_3$ parameters space is a possible similarity of the substructures found for the clusters and the clouds that are projected in their direction.

The opposite occurs for the clusters that have $\mathcal{Q} > 0.8$ (empty circles), including NGC 6530 (indicated by error bars), which do not show the same clustering structure observed in the projected clouds. The values of $\mathcal{Q}$ obtained for these clusters suggest they are more centrally concentrated, while the nearby clouds have small scale substructures.

In fact, the original geometric structure of the gas distribution is expected no longer be the same of the remaining cloud after the cluster formation.their epithelioid and myofibroblastoid properties including tight junctions, gap junctions, external laminae and contractility. The tight junctions provide selective barrier to chemical substances.

The perineurium is a smooth, transparent tubular membrane which may be easily separated from the fibers it encloses. In contrast, the epineurium is a tough and mechanically resistant tissue which is not easily penetrated by a needle.

See also
 Nerve fascicle
 Endoneurium
 Epineurium
Connective tissue in the peripheral nervous system

References

External links
  - "Peripheral nerve"
  - "PNS, nerve (LM, Low)"

 Diagram at Howard
 Histology at ucla.edu

Category:Neurohistology


short hash

2. Add a step to generate the hash

3. Add a parameter to store the hash

4. Add a second build configuration and add a dependency to the first one

5. You can now consume the parameter in the dependent step

6. At this point you can use it in the assembly info patcher

The alternative to this is to write your build number back to Git using the VCS labeling build feature.

Hope this helps.

payments to Alnylam, was announced by the New Jersey drug maker Monday. The Medicines Company's CEO Clive Meanwell described the therapy in a statement as a “gene silencing” treatment that can help keep a lid on unmanageable LDL levels. Alnylam will shoulder the cost of pre-clinical and in-progress Phase I clinical studies, and the Medicines Company will take over from Phase II onwards, including commercialization.

The government's roster of Text4 programs is increasing by one: TXT4Tots, and the Department of Health and Human Services issued a Request for Information to get a sense of how it could reach as many families as possible. The program includes a library of health-related information for children between 1 and 5, and includes tips about nutrition, snacking and exercise, among other topics. Sample


from the lHb primarily synapse on GABAergic neurons in the midbrain [@pone.0060678-Brinschwitz1], lHb innervation of substantia nigra and VTA neurons is relatively sparse and does not selectively target GABAergic neurons [@pone.0060678-Omelchenko2], suggesting they are not solely responsible for the population-level inhibition of DA neuron activity observed in response to lHb stimulation.

A recently described brain region, the mesopontine rostromedial tegmental area (RMTg or tail of the VTA) receives a dense projection from the lHb, is comprised of GABAergic neurons that project massively to midbrain DA neurons [@pone.0060678-Jhou1], [@pone.0060678-Kaufling1] and expresses Fos positive cells in response to psychostimulants such as d-amphetamine [@pone.0060678-ColussiMas1] and aversive stimuli such as footshock [@pone.0060678-Jhou2]. RMTg neurons are excited by footshock, cues predicting footshock, and the unexpected omission of a predicted reward [@pone.0060678-Jhou2], [@pone.0060678-Hong1]. The RMTginvestigating cFos expression in the RMTg [@pone.0060678-Jhou2]. Systematically random sampled sections spaced at 120 µm apart were incubated at room temperature successively, with 3 PBS rinses following each step, in 1) 0.3% H~2~O~2~ in PBS for 30 min, 2) rabbit anti-cFos polyclonal primary antibody (1∶5000), 3.0% Normal goat serum, 0.3% Triton-X in PBS overnight, 3) biotinylated goat anti-rabbit secondary antibody (1∶600), 1.0% Normal goat serum, 0.3% Triton-X in PBS for 30 min, 4) avidin-biotin immunoperoxidase in PBS for 30 min, and 5) 0.03% DAB, 0.02% nickel ammonium sulfate in PBS for 2--5 min. This change in the immunostaining procedure led to increased object/background contrast relative to the procedure used in the low-intensity experiment.

Tyrosine Hydroxylase (TH) {#s2h}
-------------------------

Sections adjacent to cFos processed sections were immunostained for TH using DAB-nickel with


expression in the RMTg. Lesions of the fr had no effect on shock-induced cFos expression. Elevated cell counts in no shock rats relative to the low-intensity experiment may be the result of a change in immunostaining procedures (see Methods).](pone.0060678.g004){#pone-0060678-g004}

The effects of high-intensity footshock on cFos expression in the Hb are illustrated in [Figure 5](#pone-0060678-g005){ref-type="fig"}. Although there was a trend toward elevated cFos in the mHb following shock (F~(1,21)~ = 3.97, p = 0.06), no significant effects were present. Within the lHbm, there was a significant main effect of shock (F~(1,21)~ = 26.61, p\<0.05) while the main effect of lesion for the lHbm was not significant (F~(1,21)~ = 0.71, p\>0.05). Similarly, there was a significant main effect for shock (F~(1,21)~ = 12.91, p\<0.05) in the lHbl with no significant main effect of lesion (F~(1,21)~ = 1.73, p\>0.05). Like the lHbm, shockreduce footshock-induced cFos expression in the RMTg core, which implies that habenular efferents play a significant role in the activation of RMTg neurons in response to mildly aversive stimuli. However, fr lesions had no effect on RMTg cFos expression following high-intensity footshock. Since fr lesions were partially incomplete we cannot exclude the possibility that the remaining fibers in the fr were recruited during high-intensity stimulation. However, we found no evidence of a contribution made by lesion size to the main effect of shock on cFos expression in the RMTg (data not shown). The inability of fr lesions to prevent cFos expression in the RMTg following high intensity footshock suggests that other inputs to this region mediate this effect, possibly including brain areas directly involved in nociception. While Hb


exposed to footshock. Moreover, as shown in [Figure 1D and 1E](#pone-0060678-g001){ref-type="fig"}, the increase in cFos expression following low-intensity footshock is localized in the lHbm near the parvocellular subnucleus. The lHbm contains a high-density of TH positive fibers ([Figure S2A](#pone.0060678.s002){ref-type="supplementary-material"} and [@pone.0060678-Geisler3]) and DA concentrations in this subregion are dramatically reduced by 6-OHDA lesions of the VTA [@pone.0060678-Phillipson1]. Since ascending DA projections to the Hb travel within the fr [@pone.0060678-Skagerberg1], [@pone.0060678-Li1], lesions of this pathway would be expected to reduce DA innervation of the Hb. This supposition is supported by the decrease in habenular TH immunostaining following fr lesion observed in the present study. While the effects of DA on lHb neurons are incompletely understood, the habenula shows decreased glucose utilization following acute administration of direct and indirect DAis also responsive to aversive stimuli [@pone.0060678-Zhu1], [@pone.0060678-Chastrette1], [@pone.0060678-McKitrick1]. Despite these similarities to the lHbm we did not see a similar pattern of change in PVTp cFos expression. While generally supportive of a role for DA in altering habenular activity during exposure to aversive stimuli further studies are needed to clarify this feedback mechanism.

Recent tract tracing studies have shown that habenular projections to the RMTg arise mainly in the lHbl while the LHbm contributes to a lesser extent [@pone.0060678-Goncalves1]. These authors also demonstrated that habenular projections to the VTA, specifically the DA neuron dense paranigral subnucleus, arise mainly from the parvocellular subnucleus of the lHbm. This would suggest that aversive events that activate the lHbm cause direct activation of some DA neurons. While the firing rate of most


lines delineate the mHb, lHbm, and lHbl (C) and PVTp (E).Scale bar = 500 µm (A,C,E), 125 µm (B,D,F).

(TIF)

######

Click here for additional data file.

######

**Representative photomicrographs illustrating the effects of fr lesion on the expression of TH in the Hb and PVTp.** TH immunostaining (dark grey) in the Hb of a sham (A) and lesioned (B) rat Illustrates the significant decrease in habenular TH expression following fr lesion. TH immunostaining in the PVTp is unaffected by fr lesion, as illustrated by comparing a sham (C) and fr lesioned rat (D). Scale bar = 500 µm.

(TIF)

######

Click here for additional data file.

######

**Representative photomicrographs illustrating the effects of high-intensity footshock on the expression of cFos in the RMTg, Hb and PVTp in a sham operated rat.** cFos expression within the RMTg (A,B),Q:

Python: Find identical items in multiple lists

I have a list of an arbitrary number of lists, for instance:
[[1,2,3], [3,4,5], [5,6,7], [7,8,9]]

Now I would like a list containing all elements that are present in more than one list:
[3,5,7]

How would I do that?
Thanks!

A:

The same way as you'd do it by hand:
seen = set()
repeated = set()
for l in list_of_lists:
  for i in set(l):
    if i in seen:
      repeated.add(i)
    else:
      seen.add(i)

By the way, here's the one liner (without counting the import) that some people were seeking (should be less efficient than the other approach)
from itertools import *
reduce(set.union, (starmap(set.intersection, combinations(map(set, ll), 2))))

A:

Another simple solution (one line):
 set.intersection(*[set(list) for list in list_of_lists])

A:

Cleanest way would probably be


of his neck, the staples in his hairline, and the shagginess of his shirt. What isn’t working as well are his shoes. They’d fit in just fine at a disco, but platform shoes don’t work quite as well on a monster.

There’s also the issue of how pronounced the joints on his arms are. They’ve got a great range of motion, but they’re way too prominent. I’m not sure if that’s a problem of the sculpt or the paint job.

Speaking of which, the rest of the paint is spectacular. Rather than trying to explain to you how magnificently they did, I’ll just leave this close up here so you can see for yourself.

My final thought is this figure is more than worth the SRP of $24.99. For any loversComparison of the Radiologic, Arthroscopic, and Clinical Outcomes between Repaired versus Unrepaired Medial Meniscus Posterior Horn Root Tear During Open Wedge High Tibial Osteotomy.
The efficacy and outcomes for the concurrent repair of medial meniscus posterior horn root tear (MMPHRT) during open wedge high tibial osteotomy (OWHTO) are unclear. This study compared the radiologic, arthroscopic, and clinical outcomes between repaired and unrepaired MMPHRT during OWHTO. Fifty-seven patients were prospectively enrolled from 2014 to 2016. The radiologic, arthroscopic, and clinical outcomes were compared between 25 patients who underwent OWHTO with all-inside repair of MMPRT using FasT-Fix (repaired group) and 32 patients who underwent OWHTO without repair of MMPRT (unrepaired group) with a mean 2-year follow up in both groups. The meniscal healing status was classified as complete, partial, or no


Google Services Inaccessible Due to BGP Leak

Important Google services were inaccessible for some users on Monday due to a BGP leak that caused traffic to be directed through Russia, China and Nigeria. It’s unclear if the incident was caused by a configuration issue or if it was the result of a malicious attack.

The Border Gateway Protocol (BGP) controls the route of data across the Internet. BGP hijacking (route hijacking) and BGP leaks occur when IP address groups are intentionally or accidentally taken over by corrupting the routing tables that store the path to a network.

According to network monitoring company ThousandEyes, a BGP leak occurred on Monday when traffic to Google Search, G Suite and various Google Cloud services was directed through TransTelecom in Russia, Nigerian ISP MainOne, andhigher than the control one, if the marker is expected to be increased in patients, and reciprocally if the marker is expected to be higher in controls. All computations were performed with the R statistical package v2.5 (<http://www.r-project.org/>). For the ROC analyses, we used the R ROCR library \[[@CR20]\]. All tests were performed using a bilateral formulation. P-values less than 5% were considered as statistically significant. All metabolic distributions and ROC curves were drawn using Graph-Pad Prism software.

Results and discussion {#Sec8}
======================

Genotype/Phenotype classification of full LND and LN Variants {#Sec9}
-------------------------------------------------------------

The French cohort of Lesch-Nyhan patients was split into the three approved sub-groups \[[@CR3]\] depending on the degree of neurological disturbances, from none to severe: HRH, HND, LND. It should be stressed that the average diagnosis age of the patient


499 Fairview Ave

PUBLIC RECORD - Built in 1950, this single family residential house at 499 Fairview Ave, Baltimore MD, 21224 is approximately 1,192 square feet. with a value per Sqft of $$129 499 Fairview Ave is located in the Baltimore County Public Schools. The closest school is Berkshire Elementary School.

The median days on the market for properties in this area is 67 with a median list price of $164,900 and median cost per square foot of $160.This property is currently off-market.

As of today, , there are 407 properties for sale in the 21224 area and 3,102 properties listed for sale in the city of Baltimore. This single family residential home at 499 Fairview Ave in ZIP code 21224 was last listed for $153,666. This is 7% below thedoor from yet another business trip.

It was ugly.

Something had to be done.

So August 19, I grabbed a journal and wrote the following reasons why I was about to make some drastic changes.

1. I feel like my husband is embarrassed by me.

2. I’m embarrassed by me.

3. I weigh more than I should.

4. I ache.

5. I don’t want diabetes at 41.

6. I don’t want to fight this battle at 42.

7. I want to stop using food as a crutch.

8. I want to set a good example for my kids.

9. I don’t want to avoid mirrors for the rest of my life.

10. I feel old.

And then I went hard-core on a special program and cut out sugar, bread, potatoes and any and all fast and fried food and got seriously cranky


I might have said I was going to die a few weeks ago when I had the Black Plague but as you all know, I *might* be prone to a little hyperbole every once in a while especially if it can be used for dramatic effect or a good blog post.

I do not particularly enjoy going to the doctor and so I have to be good and dead sick before I will darken the doors of a medical establishment. My last practice which I chose 11 years ago when we moved to NC based on the fact it was a) on a street I could find, and b) they could see me that day, turned out to be a crunchy, holistic sort of place run by a guyMainly because I need to clear them of all the stuff that Craig piled on top of them when he cleaned out his office and didn’t know what to do with random and sundry items so he stacked them on the table in hopes that the Household Fairy would magically make them go away.

Little does he know that the Fairy is French and therefore on strike until after the holidays.

Speaking of the French, that reminded me of pastries which reminded me of these little gems that I have sitting in my cupboard just waiting for a steaming cup of coffee for accompaniment.

My friend Shannon went to Texas over Thanksgiving and brought back an assortment of bread products from Mrs. Baird’s. For those of you not from the Promised


23721 is divided by 29?
28
What is the remainder when 37316 is divided by 1777?
1776
What is the remainder when 616822 is divided by 205596?
34
Calculate the remainder when 21249 is divided by 4247.
14
Calculate the remainder when 2275 is divided by 533.
143
What is the remainder when 2652 is divided by 9?
6
What is the remainder when 85836 is divided by 42906?
24
What is the remainder when 1339 is divided by 79?
75
Calculate the remainder when 82353 is divided by 12.
9
What is the remainder when 7260 is divided by 60?
0
Calculate the remainder when 4799 is divided by 121.
80
Calculate the remainder when 778 is divided by 71.
68
Calculate the remainder when 23295 is divided by 448.
447
Calculate the remainder when 2483 is divided by 122.
43
Calculate the remainder when 1912 is divided by 315.
22
What is the remainder when 4939decoupled. Gundlach & Martín García (GMG) (see [@gundlach_gauge-invariant_2000]) adapted this approach to study linear perturbations in the context of stellar collapse which has been specified to spherically symmetric dust spacetimes in Clarkson et al. (2009) (CCF) (see [@clarkson_perturbation_2009]). The authors construct a set of gauge-invariant linear perturbations of the LTB spacetime in harmonic space and derive the dynamical equations as well as a rigorous FLRW limit of those which allows a direct comparison of both models. The properties of gauge-invariant linear perturbations in LTB models have extensively been discussed in several papers ([@clarkson_perturbation_2009; @february_evolution_2014; @meyer_evolution_2015]) and, generically, two main complications arise in comparison to spatially homogeneous and isotropic background models:

-   The more complicated background symmetry causes structure formation to depend on position in the LTB patch.


The construction of boundary conditions is unaltered with respect to the previous investigations in ([@meyer_evolution_2015]) for the LTB case since boundary conditions are essentially defined by the geometrical properties of the solution. Since the center $r=0$ of the $\Lambda$LTB patch is an artificial boundary, certain conditions for regularity have to be applied there which have been found by GMG (see [@gundlach_gauge-invariant_2000])

$$\chi = {\mkern 1.5mu\overline{\mkern-1.5mu\chi\mkern-1.5mu}\mkern 1.5mu} \, r^{\ell +2}\,, \ \varphi = {\mkern 1.5mu\overline{\mkern-1.5mu\varphi\mkern-1.5mu}\mkern 1.5mu} \, r^{\ell}\,, \ \varsigma = {\mkern 1.5mu\overline{\mkern-1.5mu\varsigma\mkern-1.5mu}\mkern 1.5mu} \, r^{\ell +1}\,, \ \Delta = {\mkern 1.5mu\overline{\mkern-1.5mu\Delta\mkern-1.5mu}\mkern 1.5mu} \, r^{\ell}\,, \ w = {\mkern 1.5mu\overline{\mkern-1.5muw\mkern-1.5mu}\mkern 1.5mu} \, r^{\ell -1}\,, \ v = {\mkern 1.5mu\overline{\mkern-1.5muv\mkern-1.5mu}\mkern 1.5mu} \, r^{\ell }\,.$$

For $\ell \geq 2$, this fixes all perturbation variables (as well as nearly all spatial gradients) to zeroClarkson et al. (2009) in [@clarkson_perturbation_2009], the only remaining gauge-invariant polar perturbation in the FLRW limit with initial scalar perturbations is $\varphi{^{(\ell m)}}= -2 \Psi{^{(\ell m)}}$. This result is based on the geometrical construction of gauge-invariant perturbations in spherically symmetric dust spacetimes and therefore also holds in $\Lambda$LTB models. We therefore obtain the simple initial configuration

$$\begin{split}
   &\varphi{^{(\ell m)}}(t_\mathrm{ini},r) = -2 \Psi{^{(\ell m)}}(t_\mathrm{ini},r)\,, \\
   &\chi{^{(\ell m)}}(t_\mathrm{ini},r) = 0 = \varsigma{^{(\ell m)}}(t_\mathrm{ini},r)\,, \\
   &\dot{\chi}{^{(\ell m)}}(t_\mathrm{ini},r) = 0 = \dot{\varphi}{^{(\ell m)}}(t_\mathrm{ini},r)\,, \ \dot{\varsigma}{^{(\ell m)}}(t_\mathrm{ini},r) = 0\,,
  \end{split}
  \label{lltb:initial:17}$$

for the metric perturbations which respect the grid structure and boundary conditions posed by the problem itself. The initial fluid perturbations ($\Delta{^{(\ell m)}}, w{^{(\ell m)}}, v{^{(\ell m)}}$) are then constrained by Eqs. (\[lltb:perturbation:5\]) - (\[lltb:perturbation:7\]).

All perturbation


is mainly sourced by a term $\ell^2 \varphi{^{(\ell m)}}$. This way, the coupling effects on $\varphi$ are directly mapped to $\Delta{^{(\ell m)}}$ and the curves line up for large $\ell$-modes.

\
\

The redshift dependence of the coupling effect can be seen in Fig. (\[lltb:results:fig:3\]). The $\ell$-averaged coupling strength is shown as function of redshift in the ($\Lambda$)LTB patch. As already mentioned in Sect. (\[sect:coupling strength\]), the absolute value of the $\ell$-averaged coupling strongly depends on the set of modes considered in the investigation. Nonetheless, its relative change with redshift illustrates the dependence of coupling effects at different positions in the radially inhomogeneous patch. In comparison to the curvature and density profiles we see that the coupling strength is enhanced at positions of strong spatial gradients in both profiles. There theby

$$\vec{w} = \left( \begin{array}{r}
                   j_\ell(kf(r_i)) \ j_\ell(kf(r_j)) \\
                   j_{\ell-1}(kf(r_i)) \ j_\ell(kf(r_j)) \\
                   j_\ell(kf(r_i)) \ j_{\ell-1}(kf(r_j)) \\
                   j_{\ell-1}(kf(r_i)) \ j_{\ell-1}(kf(r_j))
                  \end{array}
 \right)\,.
 \label{lltb:levin:9}$$

In fact, regarding the recursive expressions of derivatives of spherical Bessel functions

$$\begin{aligned}
 \label{lltb:levin:10}
j_\ell'(x) &= j_{\ell-1}(x) - \frac{\ell+1}{x} j_\ell(x)\,,


and development, has been to increase the functional life span of the bioprosthesis so that it can be put into patients only once, and will last the life of the patient. This has thus far been an extremely difficult goal to reach.
There may be another option, however, for the use of tissue heart valves in the younger population. Rather than building valves that last longer, it may be more appropriate to build valves that can be routinely replaced in a way that induces negligible patient morbidity. The objectives would therefore be not to have extremely durable valves, but rather valves that can be easily removed when they begin to fail and new ones inserted. The technologies that make this possible already exist with the advances made in thefield of catheter-based endovascular procedures, and the more broad field of Minimally Invasive Surgery (MIS).
The field of MIS is growing at an accelerating pace. The approach involves the use of small surgical probes, cannulas, video cameras and remote staplers and suture drivers that enable surgery to be done without requiring large incisions. Most MIS is done with several small incisions, simply to allow the passage of these instruments into the patients body. The principal advantages of MIS is that the patient is subjected to less surgical trauma and has a dramatically reduced hospital stay, which in turn significantly reduces the operating costs of the clinical center. Current generation minimally invasive procedures are being carried out using endoscopes and long-reaching surgical tools. Typically, the patient's abdomen is inflated with


I resolved to enter public life and form a group of persons who held similar views". This was the thought that killed Gandhi and deepened the roots of religious polarization and communalism in Indiasix decades ago.On 28th September, the brutal murder of 50-year-old Mohammad Ikhlaq in Dadri, in Greater Noida, by a lynch mob of 200 people on the suspicion that he consumed beef has proved once again that the thought that killed Gandhi is gaining momentum.Ikhlaq, who worked as a carpenter barely 50 kms from Delhi, lived with his ageing mother, wife, younger son and daughter. His elder son, Sartaj, an Indian Air Force personnel is posted in Chennai. The idea of India that Ikhlaq's son Sartaj was trying to protect as an engineer in the Airmembranes that are critical for the maintenance of the Golgi PI4P pools. This recruitment increases its enzymatic activity. The ACBD3:PI4KB complex formation is essential for a proper function of the Golgi \[[@B24-viruses-11-00199]\]. Also, this system could be targeted by antivirals. ITZ is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for sterol synthesis \[[@B25-viruses-11-00199]\] and sterol shuttling at cellular membranes \[[@B26-viruses-11-00199]\]. ITZ has been found to have anticancer activity and to downregulate mTOR signaling \[[@B27-viruses-11-00199]\], consequence of impeded intracellular cholesterol transport \[[@B28-viruses-11-00199]\]. Also, 25-HC inhibits lipid transport by high-affinity binding OSBP \[[@B29-viruses-11-00199],[@B30-viruses-11-00199]\].

Then, our goal was to study the effect of ITZ and 25-HC on ASFV infection in Vero cell cultures using the cell-adapted Ba71V isolate and the possible interaction of ASFV with intracellular lipids and proteins


The addition of 25-HC significantly reduced ASFV infection ca. 70% and its effect was marked at late times of infection.

Next, we evaluated other infection parameters. The expression of viral proteins was analyzed by Western blotting of infected Vero cells extracts and viral DNA replication was analyzed by real-time PCR, both at 16 hpi. Compared to cells treated with DMSO, the amount of viral protein production, p30 and p72 was reduced in cells treated with ITZ ([Figure 4](#viruses-11-00199-f004){ref-type="fig"}A). As expected, reductions found in other infection parameters with ITZ, correlated with a decrease in viral replication at 16 hpi ([Figure 4](#viruses-11-00199-f004){ref-type="fig"}B) and virus titers reduced ca. 1 log ([Figure 4](#viruses-11-00199-f004){ref-type="fig"}C).

3.4. ITZ Does Not Change OSBP Localization in Vero Cells {#sec3dot4-viruses-11-00199}
--------------------------------------------------------

ITZ inhibited the accumulation of cholesterol on VFs and these are- puncture not traumatic (\< 10 red blood cells per *µ*L) and no identifiable leukemic blast cells after cytocentrifugation;CNS 2 - puncture not traumatic (\< 10 red blood cells per *µ*L), \< 5 white blood cells (WBCs) per *µ*L with leukemic blast cells after cytocentrifugation;CNS 3 - puncture not traumatic (\< 10 red blood cells per *µ*l), ≥ 5 WBCs per *µ*L with leukemic blast cells after cytocentrifugation;Negative traumatic lumbar puncture (TLP) - puncture traumatic (≥ 10 red blood cells per *µ*L) with no leukemic blast cells after cytocentrifugation;Positive TLP - puncture traumatic (≥ 10 red blood cells per *µ*L) with leukemic blast cells after cytocentrifugation.

Relapses were confirmed by bone marrow aspirate analysis, CSF analysis or tissue biopsy, according to the site of relapse.

Possible associations between \"traumatic LP\"


differences and the glucose content is the highest (58.0%) in the alkaline extract, which can be the responsible for the different stimulation of the THP-1 cells. The inhibitory effect of the LPS stimulation was more evident for the alkaline (K5) extract, inhibiting the expression of the three genes by over than 75%, as [table 2](#pone-0110266-t002){ref-type="table"} shows. The inhibition observed for CW and HW was statistically significant, although it was not stronger as for K5, which can be observed at [table 2](#pone-0110266-t002){ref-type="table"}.

10.1371/journal.pone.0110266.t002

###### Inhibitory effect of the extracts/glucan on the mRNA expression of pro-inflammatory genes by the THP-1 macrophages, after 3 h of incubation.

![](pone.0110266.t002){#pone-0110266-t002-2}

  Extracts/Glucan (50 µg/mL)    Inhibitory effect on the mRNA expression (%)[a](#nt105){ref-type="table-fn"}            Finance Code 001.

*Associate Editor: Anamaria Aranha Camargo*

Conflict of interest
====================

The authors declare that there is no conflict of interest that could be perceived as prejudicial to the impartiality of the reported research.

Author contributions
====================

LTRS designed the study, conducted the experiments, analyzed the data. TSJ analyzed the data. SBM conducted the experiments. CCCF designed the study, analyzed the data and wrote the manuscript. RSL and CAU provided the samples and clinical data, LRC analyzed the data and wrote the manuscript. IJC analyzed the data, and wrote the manuscript, EMSFR conceived the study, supervised the experiments, analyzed the data and wrote the manuscript. All authors read and approved the final version.

The following online material is available for this article:

###### Clinico-pathological information, classification, follow up and DNA copy number of 73 patients.

######

Click


of interest {#sec0015}
=====================

None declared.

How to cite this article: Merlotto MR, Bicudo NP, Marques MEA, Marques SA. Pityriasis lichenoides et varioliformis acuta following anti-tetanus and diphtheria adult vaccine. An Bras Dermatol. 2020;95:259--60.

Study conducted at the Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
different relations incorporated the logic. So, let's say the robot wants to learn how to turn on the lights in the room, it could relate Data A -> Data B (as an action operator where A is the light switch position and B is the current light state). When it flips the switch, and sees an immediate change in the light state (turning on) it can relate this switch to that light as having a boolean equal to property, which the relation can store the analyzed properties. So, if the robot later wants to turn on the lights in a room, it will look for a switch, and test it based off of current knowledge. If outcome was not expected (switch was on, but light was off) then


   \"ConfigValue\": \"sharp{\\r\\nos android \\r\\ntrae {\\r\\ndev {\\r\\ncap {\\r\\nhw_ch_191 2\\r\\nStereoCapLorR 1\\r\\n}\\r\\ncomponent 1\\r\\n}\\r\\n}\\r\\nhwcodec_new {\\r\\navc_decoder {\\r\\nwhite_list {\\r\\nmin_sdk 21\\r\\nmin_version 1.8.1\\r\\n}\\r\\n}\\r\\navc_encoder {\\r\\nwhite_list {\\r\\nmin_sdk 19\\r\\nmin_version 1.8.1\\r\\n}\\r\\n}\\r\\n}\\r\\n}\",\n            \"id\": 421,\n            \"MachineType\": \"HUAWEI NXT-AL10\",\n            \"md5_key\": \"a8c21bfa2a81c196bcaa5b83855bfcfa\"\n          },\n          {\n            \"Factory\": \"samsung\",\n            \"ConfigValue\": \"sharp{\\r\\nos android \\r\\nhwcodec_new {\\r\\navc_decoder {\\r\\nwhite_list {\\r\\nmin_sdk 21\\r\\nmin_version 1.8.1\\r\\n}\\r\\n}\\r\\navc_encoder {\\r\\nwhite_list {\\r\\nmin_sdk 19\\r\\nmin_version 1.8.1\\r\\n}\\r\\n}\\r\\n}\\r\\ntrae {\\r\\ndev {\\r\\ncap {\\r\\nhw_ch_191 2\\r\\nStereoCapLorR 2\\r\\n}\\r\\ncomponent 1\\r\\n}\\r\\n}\\r\\ntrae {\\r\\nprep {\\r\\ndrop_mic_ms 300\\r\\n}\\r\\n}\\r\\n}\",\nk();
        if (this.j.d == 1) {
            AppMethodBeat.o(66143);
            return true;
        }
        AppMethodBeat.o(66143);
        return false;
    }

    public int h() {
        int i;
        AppMethodBeat.i(66144);
        k();
        if (this.j.f != null) {
            i = this.j.f[0];


 if (optJSONObject != null) {
                    f = (float) optJSONObject.optDouble(str3, -1.0d);
                }
            }
        }
        AppMethodBeat.o(66149);
        return f;
    }

    public boolean a(String str) {
        AppMethodBeat.i(66150);
        k();
        if (this.j.o != null) {
     {
                aVar.h = "";
            }
            this.c.putString("system_aec_config", aVar.d + "," + aVar.e + "," + str + "," + aVar.g + "," + aVar.h);
            this.c.commit();
        }
        AppMethodBeat.o(66153);
    }

    public void j() {
        AppMethodBeat.i(66154);
        if (m()) {


 }
        AppMethodBeat.o(66154);
    }

    private synchronized boolean m() {
        boolean z;
        AppMethodBeat.i(66155);
        if (this.h || this.e > System.currentTimeMillis()) {
            z = false;
            AppMethodBeat.o(66155);
        } else {
            z = true;
            AppMethodBeat.o(66155);
        }
           Exception e;
        String str = null;
        AppMethodBeat.i(66160);
        aVar.d = 0;
        aVar.e = 0;
        aVar.f = null;
        aVar.g = 0;
        aVar.h = "";
        if (jSONObject.has("SystemAECConfig")) {
            JSONObject jSONObject2 = jSONObject.getJSONObject("SystemAECConfig");
            if (jSONObject2.has("InfoList")) {


                    JSONArray optJSONArray = jSONObject3.optJSONArray("WhiteList");
                        if (optJSONArray != null) {
                            for (i3 = 0; i3 < optJSONArray.length(); i3++) {
                                JSONObject optJSONObject = optJSONArray.optJSONObject(i3);
                   String[] split2 = split[2].split("\\|");
                    if (split2 != null) {
                        this.j.f = new int[split2.length];
                        for (int i = 0; i < split2.length; i++) {


the state of translation.
Esta pagina ж do grupo que traduz o Manual do PHP para o PortuguЖs(Brasil), aqui vocЖ encontrarр informaуш

CORBA for PHP is a PHP Extension to use CORBA objects in PHP5(Zend Engine 2). It uses MICO as its ORB and will also provide an Idl-to-PHP language mapping specification and compiler.
For a PHP4 CORBA support look at the great Universe-phpext.landing fees.

“It’s just not sustainable because there are no incentives to lower fees. Brazil, for instance, is currently privatizing its airports but the concessions are given out individually, so there is more competition. If there isn’t a company interested in running a certain airport, then the local government takes over if it sees the airport as a need for the community,” he says.

Government restrictions

Even if an airline is able to manage its way around the existing restrictions, it will still have to adhere to prices imposed by the government. With the official objective of stabilizing the airline industry and ensuring its profitability after the 2001 economic crisis (although some argue it has been more about protecting state-owned Aerolíneas Argentinas), the government has been imposing price floors and ceilings


think base instincts and interests override any interest in acting. It's
easier to pull up your favourite porn and hope no one cares or pays your
actions any attention than it is to speak up and be seen as that guy walking
against the crowd.

I also think "I've got nothing to hide" is overwhelmingly more popular than
people understanding the slippery slopes involved.

------
majani
That fake Obama just below the video is a real blow for credibility

~~~
IkmoIkmo
Hah I was wondering about that

------
mrmondo
Post from Glenn Grennwald and Ryan Gallagher on FirstLook:
[https://firstlook.org/theintercept/2014/09/15/new-zealand-
gc...](https://firstlook.org/theintercept/2014/09/15/new-zealand-gcsb-
speargun-mass-surveillance/)

------
mrmondo
Another link to a live stream that's very reliable:
[http://www.radiolive.co.nz/Decision14/Video/LIVESTREAMKimDot...](http://www.radiolive.co.nz/Decision14/Video/LIVESTREAMKimDotcomsMomentOfTruthevent.aspx)

------
mrmondo
Here's the full stream recorded and uploaded to YouTube:
[https://www.youtube.com/watch?v=Pbps1EwAW-0](https://www.youtube.com/watch?v=Pbps1EwAW-0)

~~~
q_no
Too bad, the Youtube video does not play in Germany due to copyright issues.
This is a farce

------
mrmondo
How did Snowden not make the title of this post?!

~~~
4mnt
Snowden was not introducedrepository tree.

As an example, suppose packages foo-1.0 and foo-1.1 are both in the repository. After updating from foo-1.0 to foo-1.1, run eclean distfiles: source files for both versions will be kept, so if a problem occurs with foo-1.1 then the user can easily re-install foo-1.0 without re-downloading anything.

The other possible case is installing a previously removed package. Suppose that a package foo (any version) is installed on the system. After (inadvertently) removing it and running eclean distfiles, the source files for foo will be kept, so it can be re-installed without re-downloading anything.

The same examples also apply for binary packages.

To save more disk space, add the --deep option: every source file or binary package that does not correspond to some currently installed package (version does matter) will be


for a restorative, holiday mug of cocoa, topped with miniature marshmallows.

At Barneys, the jingle-belled throng was a touch more robust—it is a department store—but not so much that a saleswoman didn’t spend 10 minutes yakking with me after taking a credit card for two tubes of Kiehl’s facial cream—I have dry skin, and this is the best relief—about any number of further remedies I might try. My protests that I found additional beauty products beyond the ken fell on deaf ears, as she replied, in hyper schmooze mood, “Oh, but honey, your skin is so beautiful; I mean I’d die for those hands!” It was easily the best laugh of the day, since my very fair skin is nothing to behold, especially at 63, and my hands inparticular are more notable for a lifetime of scars and popping veins than anything that could be remotely deemed attractive. What the hell, she had a job to do, was bored, and our animated conversation was simply swell.

Likewise, one day I was downtown, and the forbidding skies just after noon—was this Berlin?— contributed to a feeling of isolation: I wandered around The Strand (unfortunately fiscally hampered by a “landmark” designation that might, counter-intuitively, cause the bookstore to close) and it, too, wasn’t racking up the sales, which struck me as weird, for books—especially the hard-to-find volumes not available on Amazon—are, happily still a ubiquitous Christmas present. I was distressed that Generation Records, on Thompson St., was also empty, although that wasn’t a patch on the store’s depleted stock,


ready for immediate occupancy—usually had a line of seven people, whether it was six a.m. or three in the afternoon. One night Booker and I dined with longtime colleague and family friend Michael Gentile at Soho’s Coco Pazzo (which took over the space of the bar Milady’s)—a restaurant of the moment, less than a year old, where tables are scarce, and the quarters close, so much so that one time when I retreated outside for a smoke, my chair backed into that of a smartly-dressed young woman who gave me a rather unseasonable stink eye. Good thing it was noisy, since I belted out of a chorus of the Stones’ inexplicably unreleased “Cocksucker Blues” for the benefit of my companions.

The Italian food is exemplary, though, as was thedexamethasone alone. Immunohistochemistry shows a similar pattern of protein accumulation within individual cells. Chromogranin B mRNA levels are unaltered by any of the drug treatments described. Treatment with dexamethasone plus NGF seems to be required for full expression of the adrenergic, neuronal phenotype in PC12 cells. Measurement of chromogranin A mRNA provides more specific delineation of neural differentiation and how it is influenced by hormones and growth factors.


At Progress Consulting, our mission is to help organizations X•L•R•8•Progress™– to see their optimal future more clearly …and realize it more quickly and easily™.

To see your optimal future more clearly, get focused!

In his landmark book, The Fifth Discipline, author Peter Senge promotes the concept of creating a learning organization – an organization that continuously expands its capacity to achieve its mission.

If that isn’t the mandate of a CEO or division leader, or any leader, what is?

However, you can’t effectively expand your organization’s capacity to achieve its mission if its mission isn’t clear and shared by everyone involved. We believe that your FIRST imperative to X•L•R•8•Progress is to lead your organization to get focused.

Organizations that lack a clear and shared focus do not effectively or efficiently achieve strong day-to-dayThe percentage of women that report emotional IPV is greater among elderly women (66%) and adult women (63%) than young women (51%).

![Type of current physical IPV (1a) and current psychological (1b) IPV by age group. a)Type of physical IPV by age group. Percentage over the total number of women who experience physical IPV b)Type of psychological IPV by age group. Percentage over the total number of women who experience psychological IPV.](pone.0221049.g001){#pone.0221049.g001}

Independently of the rest of the variables included in the model ([Table 2](#pone.0221049.t002){ref-type="table"}), being an immigrant increases the probability of experiencing physical and/or sexual IPV in adult women (PR: 1.91) and the probability of experiencing psychological IPV in young women (PR: 1.51) y adult women (PR: 1.61). Having a higher education level decreases the probability of experiencing physical/sexual


that occasional relationships are considered partnerships by some women and not by others. This fact, in addition to the sensitivity of the information collected could cause an under-representation of IPV prevalence.

Despite the limitations described here, it is important to call attention to the magnitude of physical and/or sexual and psychological IPV among younger women, above all taking into account the grave consequences for health observed among this group of women. Putting into place health services and are youth-friendly could serve as an opportunity to improve the response to IPV among women, as has been observed in the cases of health services for sexual and reproductive health. \[[@pone.0221049.ref037]\]

This study identifies both common and differential factors associated with IPV. Among the common factors, it is important to highlight the vulnerabilityHistological features associated with vemurafenib-induced skin toxicities: examination of 141 cutaneous lesions biopsied during therapy.
Dermatologic toxicities (DTs) associated with vemurafenib therapy include actinic keratosis (AK), verruca vulgaris (VV), keratoacanthoma (KA), and invasive squamous cell carcinoma (SCC), which may share histological features. The authors report the histological features to aid in distinguishing among these DTs. A 3-year retrospective examination of the authors' surgical pathology database was conducted and 141 cases of vemurafenib-associated DTs from 33 patients were identified. DTs were categorized into 3 groups: (1) cutaneous epithelial proliferations (CEP), (2) melanocytic lesions, and (3) inflammatory dermatoses. The authors compared the groups using analysis of variance, and P<0.05 was considered significant. CEP (n=120) accounted for 85% of all DTs biopsied. The most frequent diagnosis in the CEP category was VV


//console.log(tabs[0].url, tabs[0].title, tabs[0].incognito, tabs, this.bookmark_title);
    });
  });

And here's my JAVA endpoint code
import javax.ws.rs.GET;
import javax.ws.rs.Path;
import javax.ws.rs.PathParam;
import javax.ws.rs.Produces;
import javax.ws.rs.core.Response;
import org.json.JSONException;
import org.json.JSONObject;

@Path("/restcall2")
public class restcall2 {

      @POST
      @Produces("application/json")
      public Response convertFtoC(Double param) throws JSONException {

        JSONObject jsonObject = new JSONObject();
        Double fahrenheit = param;
        Double celsius;
        celsius = (fahrenheit - 32)*5/9;
        jsonObject.put("F Value", fahrenheit);
        jsonObject.put("C Value", celsius);

        String result = "@Produces(\"application/json\") Output:Twelve tips for applying the science of learning to health professions education.
Findings from the science of learning have clear implications for those responsible for teaching and curricular design. However, this data has been historically siloed from educators in practice, including those in health professions education. In this article, we aim to bring practical tips from the science of learning to health professions educators. We have chosen to organize the tips into six themes, highlighting strategies for 1) improving the processing of information, 2) promoting effortful learning for greater retention of knowledge over time, 3) applying learned information to new and varied contexts, 4) promoting the development of expertise, 5) harnessing the power of emotion for learning, and 6) teaching and learning in social contexts. We conclude with the


0. Suppose w*g - 15 = 4*x + 127, -g + 41 = 4*x. Calculate the remainder when g is divided by 16.
13
Let r(h) = h**2 - 11*h + 5. Let a be r(4). Let j = a - -31. Calculate the remainder when 30 is divided by j.
6
Suppose 375 + 549 = 33*y. Suppose i - c + 66 = 4*i, -i + 3*c + 22 = 0. What is the remainder when y is divided by i?
6
Let q(r) = r - 4. Let w be q(6). Suppose -4*a = -k - 0*k + 16, -w*k + 2 = -2*a. Calculate the remainder when 27 is divided by 12/15*(-70)/k.
13
Suppose 3*o - 57 = -a, -a + 0*a + 5*o + 25 = 0. Calculate the remainder whenZu, Fred & Toody just to name a few. Plus, by becoming a Passionate member or higher, you’ll receive a special edition Radio Festival t-shirt designed by local artist Ellen Porteus.

If that’s not enough, PBS has our biggest selection of daily prizes ever as well as major prizes dedicated exclusively to our different membership levels: Performers, Businesses, Pets, Friends for a Decade, Friends for Life and for Passionate and Patron members.

PBS Radio Festival 2017 blasts off at 12am on Monday 15th of May and touches down at 11.59pm on Sunday 28th May.

If you want to take that One Small Step from being a listener to being a member and keep PBS circling the sun, call 03 8415 1067 or sign up online here to join the community.


decade, promising to help lonely men find the elusive sex button. It's not surprising that self-styled pick-up artists (PUAs) have found a market. They offer perfect psychosexual snake-oil, cashing in on the gullibility of the desperate. Their potions are dressed up in a frilly blanket of pseudoscience, snippets of social and evolutionary psychology, stage mentalism, neurolinguistic programming and self-referential received wisdom. It is mostly marketed through far-fetched personal testimony and miraculous anecdote. Most importantly, there are so many different models offered, so many conflicting "treatments" for low sex appeal, that unsatisfied customers can drift endlessly from one treatment to the next in search of the magic sex switch.

Nonetheless, PUAs have a few PR issues to deal with. Last week a Kickstarter appeal to fund a new PUA bookcame to widespread attention when it was noticed that the proposed content of the book – the collected wisdom of the Reddit community called r/seduction and in particular the contributions of a certain Mr TofuTofu – were peppered with the most gruesomely misogynistic advice. Alex Hern at the New Statesman outlined the worst of it. Kickstarter has now removed the post and apologised, saying "the project has no place on our site".

The proposed book was horrible, but even the more mundane threads on PUA forums are peppered with nastiness. The phrase "last-minute resistance" is used in discussions of how not to take no for an answer. The PUAs insist that their advice is always framed with discussion of consent and respecting a woman's right to refuse, and it


sure whether this photograph really shows the concertina shape of this card. (I am beginning to think that I need to sign up for a photographic course!)

This sweet little image is New Heights from the Gorguss Girls range of stamps, which I bought from the Crafty Boots on-line shop. After colouring it with Promarkers and Wink of Stella pens I distressed it, just a little, with Vintage Photo ink.

I then embossed some of my Crafty Boots Delux Crafters Paper with an Embossalicious folder and used some flat backed gems, glitter card and silver mirri from my stash. Finally I added a bow and three hat pins.

As ever, the rest of the design team have been beavering away creating some inspirational projects, please take a few minutes to have"Tell me you're jumping all over that." "No, we're..." "We're waiting." "They're waiting." "Yeah." "For what?" "The big day." "We took a purity pledge." "Son, what's the name of the cult that you're in?" "Pleasant Hill Baptist." "That boy's taken one too many shots to the head." "Sounds like all the other college offers." "A nice house?" "Yeah." "The kids going to college for free?" "What was I thinking?" "Look, the players are handpicked, self-motivated, smart, eyes fixed on their bright futures." "They don't need what I do, Bev." "They don't need a coach who knows the game inside and out?" "Who knows how to teach kids to become honorable, accountable men with self-worth?" "Bob, you do it and I've watched you do it brilliantly since I was


"♪ This is how we do it ♪" "♪ This is how we do it ♪" "♪ Sha-la-la-la-la-oh ♪" "♪ Sha-la-la-la-oh-oh ♪" "♪ This is how we do it ♪" "♪ Mm-ah-mm-ah-mm-ah-oh ♪" "♪ This is how we do it ♪" "♪ It's Friday night And I feel all right ♪" "♪ The party is here on the west side ♪" "Yo, Lamarco." "Come on, man." "One minute." "Let me cop these digits." "Get them and come on." "I gotta get home." "One minute, coz." "You gonna give me them digits, or what?" "You see my ride here." "Lamarco, come on!" "I'm coming." "I'm gonna call you." "♪ All the gangbangers forgot About the drive-by ♪" "♪ You gotta get your groove on Before you go get paidgonna answer the truth:" ""Bellevue played better than us and we lost a high-school football game."" "That's football." "But it's not you." "Don't let a game define who you are." "Let the way you live your lives do that." "Coach." "I truly believe that life's most impressionable lessons are ones where something bad happens to you or something challenging confronts you." "No one can climb into your head and hear what that little voice is saying to you." "Is it saying, "Oh, no, we lost the streak"?" "Well, what's it gonna say?" "After today, you're gonna find out a lot about yourselves." "And you know something, we're all gonna find out what this team is made of." "The effort you put in during the off-season was commendable." "But


brave." "This is not that." "Here, nobody bounces." "We are gonna break up into three groups." "When you hear your name, follow the nurse who called it to the appropriate unit." "Let's go." "Nurse Adams is in charge of the Recovery Ward, and she will take over from here." "Good afternoon, gentlemen." "Welcome to the VA Recovery Ward." "So here we specialize in transplants, amputations and general rehabilitation for limb recovery." "Our focus here is on full recovery, body and spirit." "If this is too hard for anybody, don't come in." "Why would it be?" "All our patients are here for rehabilitation." "Our job is to help them recover from traumatic injuries received during combat." "It's long and difficult, but we're dedicated to getting them back to fullythe...?" "Hey!" "Hey, man!" "Ha, ha, ha." "Is that...?" "Was that pee?" "Well, it sure ain't no Gatorade." "Ha, ha." "Oh, heck, no!" "Hey, nurse!" "Come on, man!" "Come on, Danny." "You gotta speed this up." "All right." "Let him catch up, though." "Oh, great." "You're a real gentleman." "On, baby." "Stop." "Salinas." "Quit it." "Salinas, enough." "I don't know if it is fast enough." "Show me what you got." "Let's go, Danny." "Show him what you got." "One night we get overrun." "I just curled up, waiting to die." "Till somebody dragged me into this deserted mosque." "I look at the guy who just saved my butt." "He's just some hillbilly kid from Arkansas." "Hey, at least you got out." "If they could put me back together,


gain." " Hey, hey!" "What was that?" " Oh, man." "Buster Matthews has crushed one of the smallest players on the De La Salle team." "Arturo Garcia is listed at only 147 pounds." "That's gonna cost the Jackrabbits 15 yards, making it third and long." "Oh, man!" "Arturo Garcia gets revenge, making a huge tackle to keep Poly from making a critical first down." "Get up, Arturo." "Spartans' second string is playing tough against the bigger Poly team and made them scrape for every yard." "The question is, how much longer can Terry Eidson leave these guys in before Poly's offense explodes?" "Great!" "That was amazing." "Amazing." "Poly lines up for afieldgoal." "Highsnap ." "The kick is up, and... no good." "Yeah!" "Let's go!" "See that?" "That's on"Chris is getting blocked by 280-pound guards while playing linebacker, then being tackled by 300-pounders when he's running the ball." " That's how you wrap them up!" "Good job!" " Get off of him!" "How are they still on their feet?" "Those linebackers are flying out of there." "Run the draw." "Go." "Set, hike!" "Come on, Chris!" "Come on, Chris!" "Yeah!" "Go!" "Chris Ryan's spectacular run puts the Spartans back on top, 28-24." "What do you think?" "You can't play with the Beast." "You can't play with the Beast." "With two minutes left in what is a classic high-school football game..." "Hut!" "Shed these blocks!" "These guys are half your size." "Start playing like the number-one team in this country before you aren't!" "Derrick Jones makes an unbelievable


"Green 37." "Down." "Forty back." "Watch out for 2." "Come on, D. Come on, D." "Yeah!" "Yeah!" "Ah!" "Yeah, Spartans!" "Let's go!" "De La Salle started their season 0 and 2 and lost their win streak," "But have come back to stun the football world by knocking off the number-one-rated team in the country." "Folks, I have played football and gone home exhausted," "I have broadcast games and gone home elated, but today, I go home inspired." "It is amazing win that The De La Salle Spartans have a new lease on life as they go into league games in Northern California." "Hey, coach." "Coach Ladouceur." "Can I get a comment?" "Danny." "Hey." "Hey, Dad." "You made a heck of a play on second down." "You saved theor die ♪" "♪ I will never forget ♪" "Remember one other thing:" "Nobody on this staff expects you to play perfect tonight." "That's impossible." "But what we do expect, and you should expect from yourself and each other, is a perfect effort." "♪ Oh ♪" "I'll say this about Bob Ladouceur, that he's a better coach than our big-time college coaches, and he's a better coach than our big-time pro coaches." "♪ That's how the story goes ♪" "Everybody stands up as an individual and says, "My name is DJ Williams."" "I commit to 20 carries, 150 yards, seven tackles and no dropped passes."" "Once you say that, you hand the card to somebody, and you shake hands." "And they say, "I hold you to that commitment.""


say CBD-infused creams definitely won't reduce your acute pain or muscle soreness. That's because pretty much all of these creams on the market right now have other scientifically-proven analgesic compounds, like menthol, camphor, and capsaicin which are also found in other, non-CBD topical pain relievers. "Any cream with a heating or cooling sensation desensitizes the nerves to pain by distracting them with stimuli on top," Dr. Colberg explains. Plus you're often massaging the area as you apply, which improves circulation and reduces muscle spasms, he adds.

Real Scientific Hemp Oil™ CBD isolate is a pure isolate powder containing 99% CBD, our highest concentration CBD product available. Free of taste and smell, RSHO™ isolate is ideal for blending into your own CBD oils or tinctures. RSHO™ isolate contains no measureableto promote peace and stability,” Bishop said. “We couldn’t be more delighted that the UK will be taking an increasing role in the Indo-Pacific.”

Q&A What is the South China Sea dispute? Show Control of the South China Sea is one of the most contentious and explosive diplomatic issues in East Asia. For centuries, various regional powers have laid claim to the sea, which is rich in fisheries and serves as a shipping lane for more than half of the world’s oil tanker traffic. China maintains fierce territorial disputes with Vietnam, Taiwan, Malaysia, Brunei, and the Philippines over the 3.5m sq km stretch of water that is also believed to have significant oil and gas reserves. At the peak of animosity during the 1970s and 1980s, China and Vietnam


The present invention relates generally to fuel pumps for vehicles and, more particularly, to an abrasion wear resistant fuel pump for a vehicle.
It is known to provide a fuel tank in a vehicle to hold fuel to be used by an engine of the vehicle. It is also known to provide a fuel pump to pump fuel from the fuel tank to the engine. One type of fuel pump is known as a high-pressure turbine fuel pump. The high-pressure turbine fuel pump typically includes a plastic impeller rotatable between anodized aluminum plates. The anodized aluminum material of the plates provides for a hard abrasion wear resistant surface. However, a die casting process used to form the plates limits the geometric complexity and surface smoothness of a flow channelEnhanced the Therapeutic Effects of Doxorubicin {#s3d}
-------------------------------------------------------------------------

Even though we observed that low doses of rmhTNF-α or RGD-rmhTNF-α could not inhibit tumor growth when administered alone, we investigated whether a targeted delivery of low doses of RGD-rmhTNF-α into tumor vessels could function to enhance the antitumor activity of chemotherapeutic drugs in the H22 and S180 tumor models. While combination therapy of doxorubicin with low doses of rmhTNF-α did not inhibit H22 or S180 tumor growth ([Figure 2A](#pone-0087036-g002){ref-type="fig"} and [Figure 3A](#pone-0087036-g003){ref-type="fig"}), the double-agent combination therapy of doxorubicin with RGD-rmhTNF-α at the 50,000 IU/kg dose induced a stronger antitumor effect on H22 tumor-bearing mice compared to that induced by the single doxorubicin agent ([Figure 2A](#pone-0087036-g002){ref-type="fig"}). Moreover, doxorubicin synergized with 10,000 IU/kg of RGD-rmhTNF-α to inhibit tumor growth of S180 allografted tumors


catalogs of waveforms, which represent certain regions of the physical parameter space.

Binary Black Hole Merger Simulations {#bbh}
====================================

\[b\]

[p[3.5cm]{}p[2cm]{}p[2cm]{}p[2cm]{}]{} Name & Q & HR & RO3\
Mass Ratio, $q=m_1/m_2$ & 1 – 2.5 & 1 – 4 & 1.5 – 4\
Spin magnitude, $a$ & 0.0 & $0.0-0.9$ & 0.4, 0.6\
Tilt Angle, $\theta$ & 0.0 & 0.0 & $45^o-270^o$\
N waveforms & 13 & 15 & 20\

The waveform produced by solar and intermediate mass systems spans the sensitive band of ground based detectors through the inspiral, merger and ringdown phases. While post-Newtonian and perturbation theories adequately describe the inspiral and ringdown, numerical relativity is necessary to capture the physics of the merger. has been probing the parameter space of binary black hole mergers since the breakthrough of 2005 [@Pretorius:2005gq] achieving extreme mass ratios [@Lousto:2010ut], extreme- \log Z_\mathrm{HR}
\;\;\; \;\;\; \mathrm{and} \;\;\; \;\;\;
~\log_e B_{\mathrm{RO3},\mathrm{HR}} =
%\frac{Z_\mathrm{RO3}}{Z_\mathrm{HR}}.
\log Z_\mathrm{RO3} - \log Z_\mathrm{HR} \,.$$ If the algorithm correctly discriminates between the waveform catalogs, both $B_{\mathrm{Q},\mathrm{HR}}$ and $B_{\mathrm{RO3},\mathrm{HR}}$ will be less than unity.

Figure \[f:HRratio\] summarizes the distribution of Bayes factors for HR waveforms. The majority of the boxes lie well below zero, indicating that the algorithm correctly identifies the HR catalog as the most probable for these simulations, with $Z_{\mathrm{HR}} > \mathrm{max}
(Z_{\mathrm{Q}}, Z_{\mathrm{RO3}} )$. Qualitatively similar results are found when analyzing signals from the Q and RO3 catalogs and will be explored more fully in a follow-up publication.

This work was supported by NSF grants PHY-0955773 and 0955825, SUPA and STFC UK. Simulations were supported by NSF XSEDE PHY120016 andPHY090030, and CRA Cygnus cluster.

[^1]: <http://www.einsteintoolkit.org>

[^2]: [http://www.cactus code.org](http://www.cactus code.org)