under ultraviolet light. The amplification products were then cleaned up from agarose gel with the Nucleospin® Extract kit (Macherey-Nagel, <http://www.mn-net.com>), cloned into pGEM-T® (Promega, [www.promega.com](http://www.promega.com)) and sent for sequencing at Macrogen (<http://www.macrogen.com>). The BLAST search program using default parameters [@pone.0026855-Altschul1] was used for sequence alignments.

Southern blot analysis was carried out as described by Hummel et al. [@pone.0026855-Hummel1]. Genomic DNA (5 µg) was independently digested with *Hin*dIII and *Nde*I restriction enzymes. T-DNA RB (591 bp) and LB (986 bp) probes were obtained by PCR of the pDB10 plasmid (Institut National de la Recherche Agronomique, Versailles, France) using respectively CGCCGATGCAGATATTCGTAAT/AGTTCATAGAGATAACCTTCACCCG and TCGTCAACCACTACATCGAGAC/CAGGATATATGCCAACGTAA as primer pairs. The resulting PCR products were sequenced and used to generate digoxigenin (DIG)-labelled DNA probes [@pone.0026855-Hummel1]. Immunodetection of hybridised probes was carried out as described incontact local law enforcement immediately.”

Bullinger, a pilot, had just purchased the home last month with his wife, 57-year-old Cheryl Baker. The couple was in the process of moving to Idaho from Utah when one of Bullinger’s relatives called police to ask for a welfare check, saying the family hadn’t been heard from for a few days.

The sheriff’s deputy responding to the home noticed signs that something was amiss and so began looking around the tiny farmhouse and wooded lot, Dashiell said. That’s when the deputy discovered a gruesome scene: A shed on the property held three badly decomposed bodies, each laying side-by-side and hidden under some sort of covering. Several dead birds and dogs — likely family pets — were also found on the property, and other living


help reduce stress and increase emotional . We are entitled to those feelings, whether it is towards someone, untangling a messy situation, or self-reflection, a journal is a safe place to vent, blurt out, and brag without appearing foolish. If we are encouraged to be non-judgmental, peace-loving humanitarians who endure every situation with strength, patience, grace, and a smile, a journal can be that dark place where it is okay to have that epic Charlie Sheen or Kanye West style rant and still have friends.

Journaling is more of an art than a science. There are no rules with journaling. It only takes one word to start. Here are a few guidelines for that first word:

1. Pick a Journaling Process

Do you want to write in a book, type, orHe Hali`a Aloha No Lili`uokalani

Celebrate the 20th annual Queen Lili'uokalani's birthday festival, known as He Hali`a Aloha No Lili`uokalani. It is an all-day event in Lili`uokalani Gardens with live entertainment, mass hula, craft and demonstration booths, food trucks along Lihiwai Street, children's games, tea ceremony in Shoroan, and more! This is a free event with festivities beginning at 10 am!


                               UnwrappedLineConsumer &Callback)
    : Line(new UnwrappedLine), MustBreakBeforeNextToken(false),
      CurrentLines(&Lines), Style(Style), Keywords(Keywords), Tokens(nullptr),
      Callback(Callback), AllTokens(Tokens), PPBranchLevel(-1) {}

void UnwrappedLineParser::reset() {
  PPBranchLevel = -1;
  Line.reset(new UnwrappedLine);
  CommentsBeforeNextToken.clear();
  FormatTok = nullptr;
  MustBreakBeforeNextToken = false;
  PreprocessorDirectives.clear();
  CurrentLines = &Lines;
  DeclarationScopeStack.clear();
  PPStack.clear();
}

void UnwrappedLineParser::parse() {
  IndexedTokenSource TokenSource(AllTokens);
  do {
    DEBUG(llvm::dbgs() << "----\n");
    reset();
    Tokens = &TokenSource;
    TokenSource.reset();

    readToken();
    parseFile();
    // Create         // binary operators is a bit hacky.
          bool NextIsObjCMethod = NextTok->isOneOf(tok::plus, tok::minus) &&
                                  NextTok->OriginalColumn == 0;

          // If there is a comma, semicolon or right paren after the closing
          // brace, we assume this is a braced initializer list.  Note that
          // regardless how we mark inner braces here,


we will overwrite the
          // BlockKind later if we parse a braced list (where all blocks
          // inside are by default braced lists), or when we explicitly detect
          // blocks (for example while parsing lambdas).
          //
          // We exclude + and - as they can be ObjC visibility modifiers.
          ProbablyBracedList =
              NextTok->isOneOf(tok::comma, tok::period, tok::colon,
       if (FormatTok->isBinaryOperator())
        nextToken();
      break;
    case tok::caret:
      nextToken();
      if (FormatTok->Tok.isAnyIdentifier() ||
          FormatTok->isSimpleTypeSpecifier())
        nextToken();
      if (FormatTok->is(tok::l_paren))
        parseParens();
      if (FormatTok->is(tok::l_brace))
        parseChildBlock();
      break;
    case tok::l_brace:
      if (!tryToParseBracedList()) {
        // A block outside of parentheses must be the last part of a


  if (FormatTok->isOneOf(tok::semi, tok::l_brace, tok::r_brace))
      return;

    // Consume the parens.
    if (FormatTok->is(tok::l_paren)) {
      parseParens();

      // If there is a class body of an anonymous class, consume that as child.
      if (FormatTok->is(tok::l_brace))
        parseChildBlock();
      return;
    }
    nextToken();
  } while (!eof());
}

void UnwrappedLineParser::parseForOrWhileLoop() {
  assert(FormatTok->isOneOf(tok::kw_for, tok::kw_while, TT_ForEachMacro) &&
         "'for', 'while' or foreach macro expected");
  nextToken();
  if (FormatTok->Tok.is(tok::l_paren))
    parseParens();
  if (FormatTok->Tok.is(tok::l_brace)) {
    CompoundStatementIndenter Indenter(this, Style, Line->Level);
    return true;
  }

  // Parse enum body.
  bool HasError = !parseBracedList(/*ContinueOnSemicolons=*/true);
  if (HasError) {
    if (FormatTok->is(tok::semi))
      nextToken();
    addUnwrappedLine();
  }
  return true;

  // There is no addUnwrappedLine() here so that we fall through to parsing a
  // structural element afterwards. Thus, in "enum A {} n, m;",
  // "} n, m;" will end up in one unwrapped line.
}

void UnwrappedLineParser::parseJavaEnumBody() {
  // Determine whether the enum is simple, i.e. does not have a semicolon or
  // constants with class bodies. Simple enums can be formatted like braced
  // lists, contracted to a single line, etc.
  unsigned StoredPosition = Tokens->getPosition();
  bool IsSimple = true;


but if you can swing it, I recommend you get on the application and play around by yourself before you get to it with friends! Look at one of the many learning resources Roll20 has to offer below or just open up a game and start teaching yourself how to roll dice, add character sheets, and use tokens and maps. Even just 15 minutes in Roll20 without the pressure of running or playing a game with other friends helps open your eyes to the way the platform works. It’s very user-friendly when you don’t have the pressure of keeping the game moving for a group of friends!

Start Slow

A lot of people feel the pressured to use every single bell and whistle in Roll20 as soon as they startOne at a Time

Once you feel comfortable in Roll20, slowly add new elements (if you want to do so). Bring character sheets, maps, and tokens into the game one at a time (likely in that order). Get comfortable with each element before adding a new one and eventually you’ll be using fog of war with tokens linked to character sheets as second nature. Don’t put pressure on yourself to learn any faster than you need to. You can play RPGs on Roll20 without pulling all the levers of the virtual tabletop at once. When you get to a point where you can, you’ll be happy to have them and not frustrated.

Learning Resources to Explore

Want resources to help you get started in Roll20? There are tons out there!

Videos

In addition


and Legendary Gunslingers coming out soon (to go along with already existing books like Legendary Rogues, Legendary Paladins, Legendary Vigilantes, Legendary Kineticists, and new hybrid classes and villain-focused class books too), as well as traditional fantasy adventures like the snow-covered centaur adventure The Horseshoe Calamity, the high-level pirate base of Fort Scurvy,and monster-focused books like Eldritch Elementalism. It’s going to be a furious finish to the year for LG for sure!

JAMES:What is one thing you want people to know about Legendary Games?

JASON: That they should totally buy one of everything! Or two. Two is good. 🙂

Seriously, though, we’re a talented team made up of some of the best authors and artists in the business, most of whom are already creating the official products people are already using. Wecomment and let me know you think. Thanks!

If you like what you’re reading please follow me on Twitter, like World Builder Blog on Facebook, check out my podcasts, find my products on the DMs Guild, tell your friends about the blog, and/or leave me a comment and let me know you think. Thanks!


that the project is officially associated with the move in any way.

Choi Gravity is one of a number of titles to recently launch on the Oculus VR Share beta, including the likes of Fire Panda’s My Neighbour Totoro and even more. VRFocus will continue to follow any and all applications of VR, bringing you the very latest.food grains in near future," the official added.

A helpline is also being set up in all the districts of the state to provide the latest information about persons stranded at various pilgrimage sites in Uttrakhand. The state government has already sent Uma Devi, Resident Commissioner of Chhattisgarh Bhavan in New Delhi and Disaster Management Secretary, K R Pisda to Uttarakhand to ensure every possible help to the stranded pilgrims from the state.

Besides, four teams from the Chhattisgarh were also deputed in Uttarakhand to organise evacuation of pilgrims hailing from the state. "So far 22 pilgrims from Chhattisgarh have been brought safely to Chhattisgarh Bhawan, New Delhi from Uttarakhand," the official added. According to sources, over 100 people from the state were stranded in the hill state.


here, that a trial court may order a parent to support a child until the child is 18 years of age or until graduation from high school, whichever occurs later. Id. § 154.001. Family Code section 157.005(a) provides that a trial court has jurisdiction to render an order of contempt for failure to comply with an order to support a child, as follows:
(a) The court retains jurisdiction to render a contempt order for failure to comply with the child support order if the motion for enforcement is filed not later than the sixth month after the date:
(1) the child becomes an adult; or
(2) on which the child support obligation terminates under the order or by operation of law.
Id. § 157.005(a).
Here, relator contends that his monthly child support obligationmay be detected on the body or in the surrounding air with the aid of trained dogs with a high degree of diagnostic accuracy.

Pathogen detection methods utilizing the keen canine sense of smell may offer a viable option for developing a rapidly deployable disease screening tool and provide valuable information about a subject's pathophysiological condition ([@B3], [@B15]). The use of trained detection dogs offers certain inherent advantages. Unlike a deployable instrument, dogs can examine thousands of samples or scan large surface areas efficiently, which is important in detecting pathogens in large herds of animals, crowds of people, objects (e.g., ships, airplanes, buildings), or areas of land. Diagnostic testing using laboratory instrumentation in an operational environment is often impeded by the lack of cleanliness, interference by air particulates, presence


search, starting at position 1 and working to position 8. When the dog found the target odor, it alerted by sitting, and was rewarded with a toy.

######

**Target viruses (BVDV AU526 and BVDV NADL) and distractor viruses (BHV 1 and BPI 3) were propagated on Madin--Darby bovine kidney (MDBK) cells using one of three media**.

  Targets                                                                       participants than for non-lottery participants. Furthermore, we expect that the change in happiness between \(T_1\) and \(T_2\) is not significantly larger for lottery participants with a free ticket than for lottery participants with a purchased ticket. If there would be a difference, the increase in happiness could be related to a monetary transfer, i.e. receiving the lottery ticket for free.

Table 1 Parameter estimates change in happiness between \(T_1\) and \(T_2\) Full size table

Table 1 provides the OLS parameter estimates for the change in happiness between \(T_1\) and \(T_2\).Footnote 13 The first column shows the parameter estimates of the lottery ticket effect on the change in happiness without including control variables. On average, people with a lottery ticket report a significantly higher change in happiness score (Panel A), where


is that in the group of free ticket holders there are individuals that intended to buy a ticket but a free one came along and the purchase never happened. In a sensitivity analysis represented in the fourth column of Table 1, we therefore distinguish between holders of free tickets who played the State lottery last year (and therefore have a higher chance to have the intention to buy a ticket) and holders of free tickets that did not play the State lottery in the last year. As shown, there is no difference in happiness gain between T1 and T2 between the two groups. In the group of people who participated in the State lottery last year, we made a further distinction between frequent and infrequent gamblers (at leastthat day. More are set to be unveiled.

In order to entice the first-time equity investor to invest in the stock market, RGESS provides a tax deduction benefit if the person’s gross total income is less than or equal to Rs.10 lakh and has never invested in shares before through a demat account (or in derivatives). Investors can put up to Rs.50,000 in an RGESS scheme and claim a deduction of 50% on the amount. For instance, on a maximum Rs.50,000, investors can avail a deduction of Rs.25,000 (50% of Rs.50,000).

Buoyed by high commissions, some distributors have started to aggressively push RGESS.

“Since the scheme has a very narrow definition of who a ‘first-time investor’ is, it’s difficult to find such investors in larger cities,” said Mumbai-based distributor Shashank Joshi.


agent also has high-commission products like insurance schemes that vie for investors’ mind space.”

Menon said DSP BlackRock wanted to try and “reach out to as many agents in as many locations as possible”.

He also pointed out that equity funds are mandated by law to collect at least Rs.10 crore in the new fund offer (NFO) period, or the scheme had to be shut down and the money returned to investors.

To be sure, the burden of paying commissions has shifted largely to AMCs from investors as was the case earlier. In 2009, the capital market regulator abolished entry loads (charges of up to 2.25% that MFs used to collect upfront at investment opening that was eventually passed on to the distributor as commission).

Since then, fund houses have been payingupfront commissions largely out of their own pockets and from exit-load collections. But last year, the Securities and Exchange Board of India (Sebi) mandated that AMCs need to plough exit-load collections back into their MF schemes.

To compensate for this, it allowed fund houses to charge an extra 20 basis points (bps) from investors, as part of the scheme’s total expense ratio (TER). A basis point is 0.01%. This latest change was part of a plan Sebi unveiled last year permitting fund houses to charge about 50 bps of additional TER to, among other things, increase penetration to areas “beyond the top 15 cities”, also referred to as B15.

After Sebi’s move, first-year payouts (upfront charges and first-year trail fees) have gone up by 25-35 bps across equity and long-term


same as if it were a mixin:
class SomeTableRef(alias: String) extends TableReference {
  def id = column("ID")
}
val joinedRef = new TableJoin(new SomeTableRef(defaultAlias), /* raw sql */)
joinedRef.id // compiles fine because of `unwrap`

Using this approach, I was able to implement the direct, from and optFrom methods as I had hoped.

Aprepitant for the prevention of chemotherapy-induced nausea and vomiting in children: a randomised, double-blind, phase 3 trial.
Oral aprepitant, a neurokinin-1 receptor antagonist, is recommended in combination with other anti-emetic agents for the prevention of nausea and vomiting associated with moderately or highly emetogenic chemotherapy in adults, but its efficacy and safety in paediatric patients are unknown. We did this phase 3 trial to examine the safety and efficacy of such treatment in children. In this final analysis of a phase 3, randomised, multicentre, double-blind study, patients aged 6 months to 17 years with a documented malignancy who were scheduled to receive either moderately or highly emetogenic chemotherapy were randomly assigned with an interactive voice response system to an age-based and weight-based blinded regimen of aprepitant (125 mg for


The most common grade 3-4 adverse events were febrile neutropenia (23 [15%] of 152 in the aprepitant group vs 21 [14%] of 150 in the control group), anaemia (14 [9%] vs 26 [17%]), and decreased neutrophil count (11 [7%] vs 17 [11%]). The most common serious adverse event was febrile neutropenia (23 [15%] patients in the aprepitant group vs 22 [15%] in the control group). Addition of aprepitant to ondansetron with or without dexamethasone is effective for the prevention of chemotherapy-induced nausea and vomiting in paediatric patients being treated with moderately or highly emetogenic chemotherapy. Merck & Co., Inc.from the nobody-wins dept

Back in 2012, a federal court ruled US websites were "places of public accommodation." The ruling (overturned on appeal) came in a lawsuit brought against Netflix by the National Association of the Deaf. It seems like an obvious conclusion -- more people get their information, news, and entertainment from the web than other sources. But the ruling had plenty of adverse consequences, especially for smaller, less profitable purveyors of online content.

Professor Eric Goldman -- who analyzes a ton of internet-related lawsuits -- had this to say at the time:

If websites must comply with the ADA, all hell will break loose. Could YouTube be obligated to close-caption videos on the site? (This case seems to leave that door open.) Could every website using Flash have to


thousands of video lectures and podcasts in response to a U.S. Justice Department order that it make the educational content accessible to people with disabilities.

Today, the content is available to the public on YouTube, iTunes U and the university’s webcast.berkeley site. On March 15, the university will begin removing the more than 20,000 audio and video files from those platforms -- a process that will take three to five months -- and require users sign in with University of California credentials to view or listen to them.

This move has more to do with the DOJ's ADA* accessibility stance, although that stance roughly aligns with the court's 2012 findings. The DOJ is named specifically in the university's statements as being the impetus for it locking up its past content.rate, you cannot consume it at all. That definitely excludes people, some (but not all) of whom have sensory disabilities. It may not be done with malice, but it is done, and is very frustrating for those needlessly excluded.

Re: Exclusion

Assume YT is able to get a 'bulk rate discount', and only pays $2 per minute.

Assume that only half of videos uploaded have content such that they need closed captioning.

It would cost $24,000 per minute to provide transcription and closed captioning for YT videos at that rate.

While I can certainly understand how frustrating it can be for people that can't watch/listen like others can, and need that extra work put forth to be able to enjoy content the same as others, it simply isn't viable to require such at


knew what it was about?) but isn't there software that could read the words aloud, or something? Imagine having a Braille printer that would print out the contents of the book after paying for a legal download.

It's not fair, IMHO, to burden disabled people further by demanding that they pay over the odds for accessible content; there ought to be a way to meet them halfway by providing materials in formats their accessibility software can work with.

Re: Re: Exclusion

No, that is not all that he is saying. He is saying that if you don't do this, our government will take someone to court and either fine them or put them in jail. A court will take money away from them. All with the full weight of the governmentblind people out of the conversation. You just have to keep on doing what you always have, and the conversation will forever be exclusionary.

It's worth noting that just about every gain in access for people with disabilities in education, public businesses, accommodation, etc (including those we all now take for granted) came about not because the free market saw a need and met it, but because lawsuits or other concerted (and usually adversarial) action made it happen.

Applying accessibility requirements to all sites may be overkill, but a state university -- a public institution -- should be held to the highest standard. I'd argue that this is an endeavor that merits additional (and specifically designated) federal funding. Make it a "space race", but to incentivize development of non-proprietary technology


the rotation inertia of the power turbine shaft. *n~p~* can be acquired by the integral of *ṅ~p~*, and *n~p~*(0) is the initial value of *n~p~*: $$n_{p} = n_{p}(0) + {\int_{0}^{t}{\overset{˙}{n}}_{p}}dt$$

In the second stage, the state of the turbo-shaft engine is determined by the load angle. Power demands of power turbine shaft are changed with *α*, and can be interpolated from the load characteristics map: $$Nv = f(\alpha,n_{p})$$

When the power turbine shaft power is not balanced, *n~p~* will change based on the following rotor dynamic equation: $$Ne - Nv = J_{Pt} \cdot n_{p} \cdot {\overset{˙}{n}}_{p}$$

The term *n~p~* can be obtained from associated Equations (10--12). In order to evaluate the accuracy of simplified on-board turbo-shaft engine, experiments were carried out under the condition of *T*~1~ = 300.5 *K*, *P*~1~ =- \overline{y_{k}^{2}}$$

16. Step 4. Check out the next sensor measurement, if it does not belong to the range $\left\lbrack {{\overline{y}}_{k} - KS_{k},{\overline{y}}_{k} + KS_{k}} \right\rbrack$, then is denoted as outlier, where *K* equals to 5.

17. Step 5. Eliminate the outlier and replace it with the following value: $$y_{k + 1} = \frac{y_{k - 1} + y_{k}}{2}$$

Gas turbine speed is directly influenced to the power of turbo-shaft engine, hence, the experiment to validate the proposed method is focused on the parameter *n~g~*. [Figure 5](#f5-sensors-12-11061){ref-type="fig"} shows the simulation of outlier discrimination and elimination for the parameter *n~g~*.

From the figure we can see that there are two outliers identified, and both of them are replaced with the new values within the rational range. Exponential smoothing is used to reduce the measurement


dual channels in [Figure 10(a)](#f10-sensors-12-11061){ref-type="fig"}, channel A is 0.04%/s, and channel B 0.02%/s. As can be seen from [Figure 10(b)](#f10-sensors-12-11061){ref-type="fig"}, three fault indicators exceed their thresholds about at 80s, dual channel faults is determined 2.4 seconds later via the logic. Both of the channels are isolated, and the sensor signal will be replaced with the model output. In [Figure 11(a)](#f11-sensors-12-11061){ref-type="fig"}, we can see that the same drift faults occur in the dual channel, and both analytic residuals violate their threshold while the dual channel residual is still below its threshold. An anomaly is detected, but which sensor is fault can\'t be recognized by the fault indicators in [Figure 11(b)](#f11-sensors-12-11061){ref-type="fig"}.

Sensor fault diagnosis logic for turbo-shaft engines is validated under the steady state from the above experiments. Modeling errors ofmean, with everybody rolling out and you having to head home?" "If it keeps going like this, I don't know what I'm gonna do." " Thanks." " It's no problem." "You wanna make a phone call to someone?" "If you get over to Madison, it might be some time before you can." "Ain't a chance I get a bail, right?" "How about family?" "All right, to bring you up to speed, we've got agents in Le Havre... shagging leads from the manifest of the Talco ship due here in a few days." "To see if we can't pinpoint the origin for the illegal containers." "That's a lot of cans." "A hundred and ten, actually." "How many agents you need to track back to where all those cans came


cooking women?”

“Yeah!” another congregate shouted. “And instead of one wife refusing to sleep with me, I’ll have multiple? What do you even call not sleeping with multiple women, a no-rgy?”

“Ohhhh shit!” the Rabbi said aloud. “I guess we didn’t think this one through.”

Effective immediately with the transaction, Mormon men only have to deal with one annoying wife per household. The rest of the Mormon wives will have the option of choosing their Jewish husband at their respective synagogues, or on Jdate.com.

Rabbi Chutzpah now has to carry the burden of Mitt Romney’s binder of women.

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Written by Rel

Ariel "Rel" Mathiowitz is a neurotic, panicky writer who details his pathetic life stories and frustrated points of view.
Rel is 6 foot 5; however, he makes himself appear to be 5 footBrowse our classified listings to find what you're looking for...

We are seeking a dependable and professional Customer Service Representatives for a large financial institution in Spokane for a long term assignment. Previous experience working in banking or support center environment is a plus! Primary duties will include answering incoming customer phone calls, assisting with various inquiries, researching and resolving problems and errors, and providing exceptional customer service! Must be comfortable working in a fast paced environment, multi-tasking, and working with various computer systems. Must successfully pass a background and credit check. For immediate consideration, please email your resume to heidi@provisional.com or apply online at www.provisional.com.


which the program object had been compiled. The method also includes selecting a container according to the meta-data. Finally, the method includes classloading the program object in the selected container.

06-21-2012

Aaron Kyle Shook, Morrisville, NC US

Patent application number

Description

Published

20080282039

METHOD AND SYSTEM FOR PROACTIVELY MONITORING THE COHERENCY OF A DISTRIBUTED CACHE - A method of proactively monitoring the coherency of a distributed cache. A cache comparison utility selects a set of cache keys from a replica cache connected to a main cache via a network. The cache comparison utility selects a first cache key from the set of cache keys and fetches a first cache value from the replica cache that corresponds to the first cache key. The cache comparison utility generates a first checksum value corresponding to the first cachesuch that the virtual machine is implemented by at least one of a plurality of interconnected physical computing devices in the distributed computing system; establishing a trusted relationship between the management appliance and the virtual machine; and providing a user with access to the virtual machine from the management appliance without further authentication credentials from the user.

07-05-2012

20120173990

MULTI-SOURCE ELECTRONIC FORMS WITH CONCEALED FIELDS - Electronic multi-user forms are provided. The use of these forms may include displaying the forms to more than one user, receiving population data from one or more user, and selectively displaying the population data to each user. The population data may be displayed to the various users based on the security authorization of the user seeing the form. Upon completion of the form by the


FET - An apparatus, comprising a load; an output FET having a drain coupled to the load; a first and second of a pair strong FETs, wherein: a) a source of the first of the pair of the strong FETs is coupled to the load; b) a drain of the first pair of the strong FETs is coupled to the source of the second of the of the pair of the strong FETs; the drain of the second pair of the strong FETs is coupled to a gate of the output FET; and a fixed current mirror is coupled to the gate of the first of the pair of the strong FETs.

09-12-2013

20140125389

EDGE RATE CONTROL GATE DRIVE CIRCUIT AND SYSTEM FOR LOW SIDE DEVICES WITH CAPACITOR - An apparatus,comprising: a PMOS current mirror have a first PFET and a second PFET coupled at their respective gates; a first current source coupled to drain of the first PFET; a second current source configured to have a current that is greater than the first current source, coupled to the drain of the second PFET; a capacitor coupled to the gates of the PFET current mirror; a third PFET gate-coupled to the current mirror; a driver NFET having a gate coupled to the drain of the third PFET, wherein a drain of the driver NFET is coupled to the capacitor.

DEAD-TIME COMPENSATION IN A POWER SUPPLY SYSTEM - One embodiment includes a power supply system. The system includes a pulse-width modulation (PWM) system configured to generate a PWM signal. The


a first output node and a first switching node. A second half bridge circuit has a second output node and a second switching node. A capacitive load is coupled between the first output node and the second output node. An inductor is coupled between the first switching node and the second switching node. Control modes are provided to couple the first output node to a supply voltage and the first switching node to ground; to couple the first output node to the supply voltage and the second switching node to ground; to couple the second output node to the supply voltage and the first switching node to ground; and to couple the second output node to the supply voltage and the second switching node to ground.

03-17-2016

Barbara Shook, Knoxville,power tool; determining a direction of the rotational motion about the axis; and driving the output member in a direction defined by the detected rotational motion of the tool, where the output member is driven by a motor residing in the power tool. Thus, the output member is drive clockwise when the rotational motion of the tool is clockwise about the axis and the output member is drive counter-clockwise when the rotational motion of the tool is counter-clockwise about the axis.

06-28-2012

20120326670

CHARGE CONTROL SCHEME FOR USE IN POWER TOOLS - A simplified control scheme is presented for use in a power tool. The power tool may be comprised of two or more lithium-ion battery cells connected in series and operable to drive the motor in the tool. A charging


first and second steering inputs. In the second, straight mode, the operator is able to steer the vehicle straight by operating both the first and second fraction devices together via one of the first and second steering inputs.

06-05-2014

20150315769

SINGLE PEDAL PROPULSION SYSTEM FOR STRAIGHT TRAVEL OF WORK VEHICLE - A work vehicle is disclosed with a propulsion system that is selectively operable in a first, turning mode or a second, straight mode. The vehicle includes a first traction device, a second traction device, a first steering input, and a second steering input. In the first, turning mode, an operator is able to steer the vehicle left, right, or straight by independently operating the first and second traction devices via the first and second steering inputs. In the second, straightsecond support section has density that is greater than a density of the first solid compressible filler material. A pair of attachment members are coupled to the second elongate outer shell and are configured for lifting the second elongate outer shell relative to the first elongate outer shell and for securing the second elongate outer shell relative to the first elongate outer shell once lifted.

09-24-2015

20160061032

VENTILATED MINE ROOF SUPPORT - A longitudinally yieldable support for underground roof support includes an elongate outer shell filled with a solid compressible filler material. At least one air ventilation tube extends between opposite sides of the support to allow a flow of air through the support as the support yields.

03-03-2016

Patent applications by Michael T. Shook, New Kensington, PA US

Ray Shook, St. Petersburg, FL


the aluminum spline but does not load the tongue. The steel insert prevents the thin teeth of the sprocket from damaging the aluminum body or aluminum spline.

12-25-2008

20100254752

Load transmitting insert for a soft spline body - A splined drive body for supporting a plurality of sprockets is disclosed. The drive body is provided with at least one composite drive body spline which consists of a first portion made up of the drive body material and a second portion made up of a different, harder material. The second portion of the composite drive body spline is an insert which includes a force receiving surface and a force transmitting surface and is operable to transmit force transmitted to it into the drive body through a force receiving surface provided on theexpression/activity is pivotal in oncogenic transformation, tumorigenesis, and metastasis.^[@R9]^ Previous studies showed overexpression of HER-2 in wide range of 0-84% among patients with CRC.^[@R8]-[@R10]^

Integrated trastuzumab and chemotherapy regimen enhanced the response rate in other cancer types such as breast cancer. Especially in those with the intestinal type of cancer.^[@R11]-[@R12]^ However in patients with CRC, contrast results have been reported in term of investigating the relationship between HER-2/neu expression and some of clinicopathological characteristics.^[@R13]-[@R14]^ Researchers recommended further study in this area to recognize and introduce the related factors.^[@R13]-[@R14]^

Therefore, we aimed to explore the expression of HER-2/neu and its correlation with clinicopathological parameters among patients with CRC during 2003-2013 in Imam Khomeini Hospital affiliated to Mazandaran University of Medical Science

MATERIALS AND METHODS {#s2}
=====================

Sampling {#s2-1}
--------

In this retrospective study, 50 consecutive patients


+1) were considered negative and scores (+2 and +3) were considered positive. According to the findings, most of the studied cases (30/50 \[60%\]) were categorized as negative ([figure 1](#F1){ref-type="fig"}).

![](MEJDD-8-24-g001){#F1}

[Figure 1](#F1){ref-type="fig"} shows 30% of samples presented +1, 30% were zero, 38% of cases presented +2, and only 2% was +3. Therefore 40% of samples considered as positive (38% (+2) and 2% (+3)).

There was no significant relationship between expression of HER and age (*p*=0.692), differentiation (*p*=0.232), stage (*p*=0.868), histological types (*p*=0.523), depth of tumor (*p*=0.941), size of tumor (*p*=0.557), treatment type (*p*=0.446), and sex (*p*=0.908).

There was no significant relationship between HER-2 expression and distant metastases (p =0.731), lymph node metastases (*p*=0.465), recurrence (*p*=0.663), vascular invasion (*p*=0.726) and lymphatic invasion (*p*=0.803). The figure -2- shows positive and negative expression of samples.54% were men. Difference of sex distribution was not considerable in this study, which is similar to other Iranian surveys such as Safaee's.^[@R2]^

In conclusion, we found 40 % of the CRC cases in Mazandaran, Iran, were positive for HER-2 and there was not statistical relationship between positivity of HER-2 and age, sex, lymph node metastasis, distant metastasis, size of tumor, and stage of disease. This may have implications for selecting CRC cases that may benefit from anti-HER-2/neu therapy. Further studies in larger scales are needed to confirm our results.

Regarding limitations such as small study populations, different design methods, an insufficient follow-up period, low concentrations of HER-2, lack of a standard scoring method, and lack of experience, there is need for more comprehensive studies with larger samples targeting with


a high rate imposes an increased load on the active material, making it difficult to maintain the cycle life by conventional techniques.
Some devices require batteries that have such high rate discharge performance and yet exhibit a flat battery voltage in the charge/discharge curves. Batteries with a positive electrode active material having a layered structure such as lithium cobalt oxide (LiCoO2) or lithium nickel oxide (LiNiO2) usually exhibit relatively flat S-shaped charge/discharge curves. Accordingly, it is difficult to maintain a flat charge/discharge voltage during high rate charging/discharging. Since the positive electrode active material repeatedly expands and contracts to a great degree in the layer direction during charging/discharging, the stress resulting therefrom reduces the cycle life particularly at the time of high rate charging/discharging.
The positive electrode active materials are recognizedLi/Li+.
Japanese Laid-Open Patent Publication No. Hei 7-320784 discloses a battery comprising a positive electrode containing Li2MnO3 or LiMnO2 as an active material and a negative electrode containing lithium-intercalated Li4/3Ti5/3O4 or LiTi2O4 as an active material. Japanese Laid-Open Patent Publication No. Hei 7-335261 discloses a battery comprising a positive electrode containing a lithium cobalt oxide (LiCoO2) and a negative electrode containing a lithium titanium oxide (Li4/3Ti5/3O4). Further, Japanese Laid-Open Patent Publication No. Hei 10-27609 discloses a battery comprising: a negative electrode containing, as an active material, lithium, a lithium metal, or a lithium-titanium oxide with a spinel-type structure; a positive electrode containing, as an active material, a lithium-manganese oxide with a spinel-type structure (Li4/3Mn5/3O4); and an electrolyte comprising a solvent mixture of not less than two components such as


##xxxxxxxxxxxxxxxxxxxxxx --*- Makefile -*-- xxxxxxxxxxxxxxxx>>> config.make
## By default, make will jump into any sub directory that contains a   file
## named "Makefile". This is done  in the order implied by "/bin/ls"  which
## is in almost  all  cases  correct  (note  that  you  should  not  design
## Makefiles which depend on a specific invocation order). You can override
## specific  behaviour  by  using  variable SUBDIRS. If given and not empty,
## "/bin/ls" is not used. Also,  if you want to disable jumping subdirs you
## may  use  either ".", ".."  as  value for SUBDIRS. Note that SUBDIRS may
## contain any directory (except "." and "..).

## This is very much GNU specific, sigh.  Variable SUBDIRS is used to tell
## make which  subdirectory to jump. It's  value is normally preset or just
## empty, in which case /bin/ls is used as discussed above. However, I also
## want that a user can say
##
##  make SUBDIRS="d1 d2 .. dn"
##
## That means, ignore defaults and go ahead and make exactly this director-
## ies mentioned. Of course, this should only have  an  impact  on Makefile
## being used  by  "make"  but not for any makefils in d1 .. dn, right? For
## example, if di  needs  to  make directories a,b and c, then they need to
## be made of course. So all burns down to the question how to prevent a
## variable


of the party, as evidenced by any photo of President Trump's shockingly white, male Cabinet, is increasingly functioning as a repellent for people considering joining or voting for the GOP.

But it isn't just demographic diversity. The 21st century has been characterized for some time by what Norm Ornstein and Thomas Mann call "asymmetric polarization," during which the GOP has led the way in its transformation into a rigidly ideologically minded organization. Data tracked by political scientists at UCLA shows the Republican Party, as measured by congressional roll call votes, becoming twice as conservative between 1980 and 2012, with very little movement to the left for Democrats. In many ways this is the most important story about modern American politics. Republican ideological unity and the party's willingness to deployruthless procedural warfare to gain and maintain power have wrong-footed Democrats for the better part of three decades now. Meanwhile, the national Democratic Party has been dominated by well-meaning pragmatists who keep getting outsmarted by their opponents.

Will 2018 finally start to change that? According to the data, this Democratic caucus is about as progressive as the last one — marginally more liberal than Democrats 10 years ago, but hardly a difference in kind like you see with the GOP. But when you think about the kinds of legislators likely to get elected in 2018, it's clear that the party is headed in a more progressive direction. Sure, some center-left Democrats won their primaries — but a number of moderates will be replaced by progressives, and the reverse is


faithfully carried out the orders and directions of the bank. No stock in the New Company was ever issued. No stockholders' meetings were held, and, when it became necessary to select new directors, they were always designated by the Bank. It was generally understood that the Bank was the owner of the assets of the New Company and was in actual control of its affairs, and during that period the Bank at large expense, involving many thousands of dollars, made strenuous efforts to sell stock or to sell the property and recoup its losses.
Mr. Brown, the president, testified that "of course the Bank was in the Wagon Company business, no question about that, but banks frequently go into businesses that they don't like to be in." He furthersitus solitus has been detectable postmortem in 0.09% of patients with congenital heart disease, and among the 121 cases reviewed with an absent right SVC, 54% had an otherwise normal heart structure \[[@B1]\]. SVC anomalies are usually asymptomatic, but they may complicate procedures like cardiac catheterization, systemic venous cannulation for extracorporeal membrane oxygenation, and transvenous pacemaker implantation. Cardiac surgery for cardiopulmonary bypass, partial or total cavopulmonary anastomoses, and orthotropic heart transplantation, for example, require exact knowledge of systemic venous anatomy.

4. Clinical Presentation {#sec4}
========================

We describe a very rare SVC anomaly with a totally absent SVC. To our knowledge, only ten previously cases are published that show the total absence or severe hypoplasia of the SVC ([Table 1](#tab1){ref-type="table"}) \[[@B7]--[@B12]\]. The first two were adults, diagnosed by venography during an attempt


association with her SVC anomaly remained unclear. An absent right SVC in visceroatrial situs solitus may be associated with abnormalities in the sinoatrial and atrioventricular nodes and offers an increased arrhythmia risk \[[@B1]\], necessitating electrocardiographic followup. Early diagnoses in newborns facilitate collection of long-term follow-up data and lead to increased knowledge of the natural course of this anomaly.

7. Conclusion {#sec7}
=============

A totally absent SVC is a very rare anomaly. Because it is usually asymptomatic, the incidence in the general population may be higher than detected. Despite the benign nature of this SVC anomaly, knowledge of the systemic venous anatomy has to be accurate prior to cardiac surgery. In case of totally absent SVC, some palliative procedures for univentricular heart defect, for example, bidirectional Glenn or total cavopulmonary connection, arestates $|\psi_N\rangle$ that each have different numbers $N$ of observational regions: $$|\psi\rangle = \sum_{N=0}^{\infty} a_N |\psi_N\rangle,
\label{state}$$ where $\langle\psi_M|\psi_N\rangle = \delta_{MN}$. (Different values of $N$ model different sizes of universes produced by differing amounts of inflation in the cosmological measure problem.) The different theories will then differ only in the prescriptions they give for calculating the observational probabilities $P_j(i)$ from the single quantum state $|\psi\rangle$. These differences will illustrate the logical independence of the observational probabilities from the quantum state, the fact that the observational probabilities are not uniquely determined by the state.

In each component state, the index $L$ can run from 1 to $N$ (except for the component state $|\psi_0\rangle$, which has no observational regions at all). As above, let us suppose that $\mathbf{P}_j^L$ is a complete


The tracks of my tears.

Time travel is damage. It's like a tear in the fabric of reality. That is the scar tissue of my journey through the universe. My path through time and space. From Gallifrey to Trenzalore.Q:

Why Definition of decreasing Sequence not Applicable here?

I have read the definition of Decreasing Sequence $\left\{a_n\right\}$ as:
$$a_{n+1}\le a_n$$ $\forall$ $n \in \mathbb{N}$
Now consider the sequence:
$$a_n=\frac{(-1)^n}{n}$$
We have:
$$\frac{a_{n+1}}{a_n}=\frac{-n}{n+1} \lt 1$$
hence
$$a_{n+1}\lt a_n$$
But Actually its not a Monotone Sequence.
What is the correction in the definition?

A:

Just because the inequality $\frac{a_{n+1}}{a_n} < 1$ is satisfied does not in and of itself imply that the inequality $a_{n+1} < a_n$. It does if the $a_n$'s; $n \in \mathbb{Z}^+$ are nonnegative.
For example, also consider the sequence $\{a_n\}; n \in \mathbb{Z}^+$; $a_n= (-2)^n$.

A:

Your claim
$$\frac{a_{n+1}}{a_n}=\frac{-n}{n+1} \lt 1$$
is false since
$$-\frac{n}{n+1}>1 ~~\text{if $n\in(-1,-\frac 12)$}$$
Furthermore, the definition of "monotonic decreasing" applied to a sequence $a_n$ means specifically that $a_{n+1} < a_n$ for every $n.$
This is not the same as $\frac{a_{n+1}}{a_n} < 1.$
In particular, if $a_n < 0$ and $a_{n+1} < a_n,$
then


seem pretty sure that the greatest tennis player of all time is either Roger Federer or Rafael Nadal who happen to be playing now. There seem to be a couple of major reasons for this.

One: Federer and Nadal are piling up grand slam championships in unprecedented numbers. Federer has won 17 of them, which is the record, and he reached the final of another seven. From Wimbledon 2005 until the Australian Open in 2010 he reached the final of all but one grand slam championship. Nadal, meanwhile, has a chance to win his 14th grand slam in Australia this weekend, that would tie him with Sampras for second place on the list.

Two: Federer and Nadal play in a time where the equipment — specifically the tennis rackets butyeah, Cavill still looks like a badass Kal-El! Remember his initial photo teasing his appearance in Man of Steel?

And, of course, he’s going to be facing off against THIS dude. More on that in a minute:

Zack Snyder pulled short of explaining, in detail, the nature of the relationship between Batman (Ben Affleck) and Superman (Henry Cavill) in the 2016 super-mega-blockbuster, emphasizing that the "v." in the title helps "keep it from being a straight 'versus' movie, even in the most subtle way." But he explains that the movie very much is about helping Kal-El, and his alter ego of Clark Kent, get more acclimated to his adopted home planet, striking out and exploring new areas (like Gotham City) and new threats (like Jesse Eisenberg’s Lex Luthor).

The director also


21 N.Y.2d 428 (1968)
Arrow Builders Supply Corp., Respondent,
v.
Royal National Bank of New York, Appellant.
Court of Appeals of the State of New York.
Argued January 15, 1968.
Decided February 22, 1968.
Stewart Maurice and Thomas E. White for appellant.
Hyman R. Friedman for respondent.
Chief Judge FULD and Judges SCILEPPI, BERGAN, BREITEL and JASEN concur; Judge KEATING taking no part.
*430BURKE, J.
Faye Zappacosta was employed as a bookkeeper by plaintiff Arrow Builders Supply Corp. Each month, she drew checks for plaintiff's president LaSala on its account in defendant Royal National Bank, payable to the order of that bank, representing income and social security taxes withheld from the wages of Arrow's employees. Between August, 1962 and June, 1964 Zappacosta drew and LaSala purportedly signed 54 such checks, of which only 23 were properly applied. The 31any checks appropriated by her, nevertheless reflected the proper total for all the checks drawn for that month. Thus, the total shown always exceeded the sum of the enumerated checks. The statement, with this tape, was then presented to the accountant who neither compared the checks he received against the debits on the statement, nor totalled these checks himself. Consequently, Zappacosta was able to perpetuate this scheme for 23 months whereas a proper review of the first statement would have exposed the first defalcation. Plaintiff brought this suit to recover the entire sum taken by its bookkeeper Zappacosta, alleging that the defendant bank paid these funds without making any appropriate inquiry as to her authority to direct the application of these checks. Defendant, conceding its carelessness, asserts as


necessary for an integrated circuit designer to custom design each individual gate and transistor in an integrated circuit. Rather, the circuit designer breaks down a new circuit design into a number of known (or new) cell designs and then combines these cells appropriately to generate a circuit design which performs a desired function. Each of the logic cells contains a number of terminals for implementing into the integrated circuit. These logic cells are commercially available.
To "tape-out" such a circuit layout, commercial "placeand-route" CAD tools, such as Cell3.TM. from Cadence Design Systems, Inc., of San Jose, Calif., can be utilized. More particularly, place-and-route CAD programs are used 1) to arrange logic cells and other elements to optimize their interconnections and the overall surface area and 2) to define thein patients with MHE and non-MHE patients did not show any difference after four hours as in controls \[[Table 3](#T3){ref-type="table"}\]. Sensitivity and specificity of CFF \<39 Hz for the diagnosis of MHE was 77 and 75%, respectively. CFF in patients with cirrhosis was significantly correlated with NCT-A (--574, *P* = 0.001), NCT-B (.313, *P* = 0.02), DST (0.476, *P* = 0.001), LTT (0.360, *P* = 0.01), and SDT (--.367, *P* = 0.009) at baseline.

######

Critical flicker frequency and Inhibitory control test in patients with cirrhosis at baseline and after 4 hours

![](SJG-19-40-g003)

ICT {#sec2-9}
---

The target accuracy of ICT was lower in patients with cirrhosis compared with controls (88.4 ± 5.6 vs. 95.6 ± 2.1, *P* = 0.01), whereas ICT lures were higher (18.3 ± 4.2 vs. 10.2 ± 2.8, *P*


compared with the first (*P* = 0.003) but no change in target accuracy (*P* = 0.97). This suggests some learning effect in the inhibition ability in patients with cirrhosis, predominantly in MHE patients. However, none showed any deterioration in attention ability as measured by target accuracy. Compared to psychometric tests and CFF, ICT was less preferred by the patients.

Psychometric tests assess psychomotor function (NCT-A), whereas the NCT-B analyzes divided attention and executive function. The DST is a test of attention and processing speed. Similarly LTT (psychomotor and visuo-spatial) and SDT measure psychomotor abilities.\[[@ref16]\] Psychometric tests have been used as a measure of cognitive functions in number of trials. We had also shown earlier that no deterioration was seen in psychometric tests after two hours of endoscopy under propofolcycle of applied voltage, such charges as are stored constituting an electrical memory.
Thus, the dielectric layers prevent the passage of substantial conductive current from the conductor members to the gaseous medium and also serve as collecting surfaces for ionized gaseous medium charges (electrons, ions) during the alternate half cycles of the A.C. operating potentials, such charges collecting first on one elemental or discrete dielectric surface area and then on an opposing elemental or discrete dielectric surface area on alternate half cycles to constitute an electrical memory.
An example of a panel structure containing non-physically isolated or open discharge cells is disclosed in U.S. Pat. No. 3,499,167 (incorporated herein by reference) issued to Theodore C. Baker, et al.
An example of a panel containing physically isolated cells is disclosed in the


A.C. and D.C. display panels utilizing a dielectric surface in contact with the gas.
In addition to the matrix configuration, the conductor arrays of the display device (D.C. or A.C.) may be shaped otherwise. Accordingly, while the typical conductor arrangement is of the crossed grid type as discussed herein, it is likewise apparent that where a maximal variety of two dimensional display patterns is not necessary, as where specific standardized visual shapes (e.g., numerals, letters, words, etc.) are to be formed and image resolution is not critical, the conductors may be shaped accordingly (e.g., a segmented digit display).of blockchain in the medical field, progress and technical framework of AIDOC project with domestic AIDOC fans.

On March 30th, AIDOC was listed at the Houbi Korean, and took the Houbi Korean as the first step to enter the Korean market. AIDOC exchanged opinions with local Korean media, exchanges, and well-known critics on overseas blockchain companies meeting this Friday and built up the layout of the Korean market! AIDOC has made efforts to develop the Korean market from multiple dimensions such as local community construction, commercial projects landing, and recruitment of core volunteers, thus improving the global strategic layout of AIDOC Chain.

AIDOC has showed on the NASDAQ giant screen recently, which demonstrates the strong brand image of AIDOC. We have the reason to believe that in the near future,


than writing in the third person. I’ve been writing as slow as I usually do. It’s just different, rather than worse.

“We are coming up on 6 years since the first Horus Heresy book was published, I know the series is very popular, but being in the know, any idea how much longer it will stretch out before they get to the end?”

“How did recent fluff regarding the Grey Knights exterminating Daemons on their home-turf ( inside the warp) and Draigo making the Dark Gods cry like pristine Japanese schoolgirls with his Chuck Norrisian round-kick, affect your work and do you agree with the changes?Also, don’t you think that making the Grey Knights unbeatable kinda makes them ridiculous ?”

Uh.

It affected my work “a lot”, in that I had tothe Black Templars if he’s a hero, and he has no idea what to say. He has no context to judge what she means, and no capacity to see the world from her perspective. He has honour badges on his armour, and a history of glory in warfare, but a simple question like that means almost nothing to him. Can he save those people? Would a hero, by their standards, do that? All he wanted to do was die in glory. To the Adeptus Astartes, that was the definition of heroism. To the human refugees looking to him as a saviour… not so much.

Grey Knights operate on that austere, inhuman level all the time. Humans are a complete mystery to them. I think that’s what’s interesting about them.

Y’know,


was symbiotically linked to the warship’s machine-spirit while they flew through the void. And the soul of the machine was so galvanised and thrilled to be hunting through the warp and destroying enemy vessels, that its primal pleasure at fulfilling its raison d’etre was starting to bleed through the link into her mind. She usually had the strength to control the machine-spirit, but she was exhausted and wounded, and her body responded in a primal and human way, as raw pleasure coursed through her mind and beyond. I knew that it wouldn’t go through editing, so I changed it.

I edited it down like crazy, and it was still cut, even when it was just a final sentence about her trying to fly the ship and ignore a distractinglyto fighting daemons in 40K, it’s a seminal and quintessential deal of the whole license. It’s the lone man with a broken sword, fighting through his wounds against a creature twenty times his size. It’s that cold, cold moment when he looks up… and up… and up… and realises he’s absolutely fucked. He’s going to die. But he has faith, and he has a hammer, and he’s the only one left to hold the line. Being equal to the daemons isn’t something that interests me, but I can see why a Grey Knight would invent the Dreadknight. I just prefer the Warhammer: Mark of Chaos trailer-style daemon fight, or Inquisitor Rex standing against the towering form of An’ggrath, or Gandalf against the Balrog.

You’ll notice Gandalf doesn’t try to


it would make it much easier to develop things like common UK frameworks or new public agencies after Brexit instead of having one imposed on us by the UK Government.

Needs More Work

Mutual Respect & The Sewel Convention – In principle this is fine, but in practice the UK Government and UK Parliament have never considered itself the equal of the devolved governments (and they don’t need to due to parliamentary sovereignty). Intergovernmental working often seems a courtesy than a constitutional responsibility and there’ve been several examples of Wales and Scotland challenging decisions made in relation to devolved powers by the UK Government which have come to nothing. The report says the UK Government will have to adopt a “self-denying ordinance in respect of legislation on matters in thethe track team was gathered in the area of the Grant Field bleachers, which have a maximum height of 20 feet, waiting for the meet to begin when Kayla spotted her sister, Lauren, sitting in an announcer’s booth, the suit said.

Kayla decided to walk over to speak with her sister, but when she climbed the bleacher stairs and crossed a section of bleachers to reach the booth, the suit said she fell through an opening between the seats and footrest.

Kayla, who fell approximately 15 feet and landed on the ground, suffered a broken right wrist, dislocated right elbow, multiple fractures of her right pelvis, facial lacerations, and other injuries, the suit said.

“The lack of any protective netting or screen to cover the openings posed a hazardous and dangerous


suit accuses the school district and the town of negligently failing to maintain the bleachers “in a reasonably safe condition” and failing to inspect them for hazardous conditions and warn of the dangers. The suit also alleges that the bleachers do not comply with the town’s life safety codes.

Salem school Superintendent Michael Delahanty said he was aware of the incident when it happened three years ago but was unaware of the lawsuit.

He learned of the litigation when contacted by a reporter seeking comment on the allegations.“I’m not aware of other injuries caused by falls on the bleachers. As for safety issues, nothing has been brought to my attention and no modifications have been made to the bleachers,” Delahanty said.Modelling DNA extension and fragmentation in contractive microfluidic devices: a Brownian dynamics and computational fluid dynamics approach.
Fragmenting DNA into short pieces is an essential manipulation in many biological studies, ranging from genome sequencing to molecular diagnosis. Among various DNA fragmentation methods, microfluidic hydrodynamic DNA fragmentation has huge advantages especially in terms of handling small-volume samples and being integrated into automatic and all-in-one DNA analysis equipment. Despite the fast progress in experimental studies and applications, a systematic understanding of how DNA molecules are distributed, stretched and fragmented in a confined microfluidic field is still lacking. In this work, we investigate the extension and fragmentation of DNA in a typical contractive microfluidic field, which consists of a shear flow-dominated area and an elongational flow-dominated area, using the Brownian dynamics-computational fluid


Group, which includes Lead Area managers and disability specialists meets monthly and receives updates on progress.

Following the meetings of the Oversight group the Regional Disability Specialists/Disability Managers engaged with local service providers to ensure a complete profile of each individual seeking to access service was submitted.

Each application is being reviewed to establish if the applicant is appropriate to specialist disability services, has the capacity to attend rehabilitative training programme or attend day services.

In relation to engagement with service users and their families the position is that in Dublin for example Individual meetings have occurred with the following:

a) School Leavers

b) Parents/Guardians

c) Teachers/Principals

d) Clinicians/Health Care Professionals (as appropriate)

Continuous communication with school leavers and parents/guardians on any issues or concerns arising regarding transition from school are ongoing with the Guidance service.

Ichanging.

d) How many State provided places are there in mainstream residential care and

e) How many are provided by Private Providers?

All Special Care placements in Ireland are operated by the Child and Family Agency and placements are under the direction of the High Court. There are no private providers of Special Care Services in Ireland, however some children with complex needs are placed out of State.

More generally, in December 2013 there were 142 Children’s Residential Centres in operation throughout the country; 47 of which were Agency-managed; 28 were run by the voluntary Sector; and 67 were operated by private providers. These centres are typically found in domestic homes in housing estates, on the outskirts of towns and villages. The centres typically have between three and six children. These children


Report is the overarching policy on neuro-rehabilitation services and includes proposals for a framework for the future of neuro-rehabilitation services in Ireland, including key elements such as:
• guiding principles;
• implementation structure;
• methodology for implementation; and
• information and communication.

The Report recognises that given the current economic climate, the focus in the short to medium term has to be on re-configuration of services, structures and resources and the enhancement of the skills and competencies required to meet the changing context.

The key priority areas, as identified in the HSE’s National Operational Plan for 2013 are to:
• Map and develop Integrated Service Area level rehabilitation networks;
• Implement the model of care for rehabilitation services within the networks with a focus on community rehabilitation.

An implementation plan beyond the overall operational plan commitments wouldmanagement of patients of equal clinical priority and implementing the recommendations of the Surgery Clinical Programme

Question 34: Children’s palliative care programme

To ask the Minister for an update on the children’s palliative care programme currently funded by Irish Hospice Foundation (IHF) and HSE. In particular: an assurance that all 8 children’s outreach nurses (5 IHF funded/3HSE funded) are now in post and if not, why and when will they be in post?; to outline the plans the Department of Health and HSE have to identify sources of sustainable funding for the Children’s palliative medicine consultant post (IHF funded) and the 8 outreach nurses when the IHF funding ends in 2016; and to confirm that children with terminal illness are entitled to the medical card without means test in the


an administrative basis in addition to its existing statutory functions. Day to day statutory responsibility for child welfare and protection services and education welfare services will remain with the HSE and the NEWB respectively until these are transferred on the enactment of the necessary legislation. This approach reflects the overall strategy to undertake as much preparation as possible in advance of legislative enactment and the consequential transfer of onerous operational responsibilities.

It is important not to underestimate the scale of change involved and the absolute necessity for a carefully planned approach to be adopted while embarking upon such large-scale change within this crucial area of the public service. The approach to the project is informed by learning from the establishment of other major agencies, particularly where preparatory time wasbased initiative that delivers on the programme’s objectives of:
Breaking the cycle of child poverty within areas where it is most deeply entrenched and where children are most disadvantaged, through integrated and effective services and interventions that address:
1. Child development, and/or
2. Child wellbeing and parenting, and/or
3. Educational disadvantage,
From pre-natal to 18 years of age.

Proposals are invited across all elements but particular consideration will be given to proposals that focus on the quality and effectiveness of services and interventions from birth to 6 years of age.

What will the programme provide?
Successful applicants will receive funding to implement proven and cost-effective early intervention and/or prevention programmes and practices. The level of funding which will be available to individual projects for the duration of the programme will vary depending on the scale and


not issued with prescription pads; if he would agree that this discriminates against qualified registered nurse prescribers working in private facilities and may impact on patient care by preventing timely symptom relief for residents with medical cards living in private and voluntary nursing homes where access to a GP may not be immediately available; and if he has plans to ask the HSE to change this?

Professional guidance is already in place with regard to scope of nursing and practice and specifically in relation to nurse/midwife medicinal product prescribing. Nurse/midwife medicinal product prescribing has been in place in Ireland since 2007 underpinned by (a) legislation, and (b) the NMBI regulatory framework. There are currently 650 registered nurse prescribers.

The issue in question is the requirement for access for nurse prescribersin private nursing homes to primary care prescription pads for the purposes of GMS reimbursement for medical card holders. This is a matter primarily for the HSE to determine.
The Department supports, in principle, nurse prescribers in private nursing homes having access to primary care prescription pads, subject to robust governance and accountability structures being put in place. The provision of nurse prescribing services in nursing homes would greatly enhance continuity of care from the hospital sector through to the nursing home sector. Medicines legislation currently in place does not differentiate between prescribing by nurse prescribers in public or private setting. Nor does it deal with reimbursement under the Community Drugs Schemes of prescriptions by nurses.
The issue of reimbursement through the Primary Care Reimbursement Service (PCRS) is a matter


not be considered a staff cutback. Similarly, the previously invested budget in cardiac rehabilitation services continues as part of the overall hospital budget. There have been no targeted reductions in cardiac rehabilitation budgets and hospitals will continue to manage this and all hospital services in line with their overall budget for 2014.

However, the report does highlight the need for further actions to ensure continuity of cardiac rehabilitation services where important clinical support services are not available for the reasons identified in the report (i.e. maternity leaves, retirements, transfer of staff, etc). Similarly, it is anticipated that demand for cardiac rehabilitation services will continue to grow requiring all units to be able to respond to increased levels of referrals in the future. The National Director of Acute Hospitals willthe recommendations of the Value for Money and Policy Review of Disability Services, and will use the recommendations of the VFM report, to focus on Disability funded rehabilitation services and enable reconfiguration of existing provision through the establishment of demonstration sites. Close links will be maintained with the Rehabilitation Medicine Clinical Programme to ensure that there is no duplication of effort and that all initiatives receive optimal support.

Demonstration sites have been identified by Disability Services and mapping has commenced.

The Rehabilitation Medicine Clinical Programme and the HSE Disability Services Division will jointly agree an implementation plan for the Neuro-rehabilitation Strategy, the first draft of which has been completed and is undergoing a process of refinement before finalisation.

Question 9: Registered Nurse Prescribers

To ask the Minister for Health the reason for


or sick leave will resume providing services as part of the cardiac rehabilitation unit and therefore should not be considered a staff cutback. Similarly, the previously invested budget in cardiac rehabilitation services continues as part of the overall hospital budget. There have been no targeted reductions in cardiac rehabilitation budgets and hospitals will continue to manage this and all hospital services in line with their overall budget for 2014.

However, the report does highlight the need for further actions to ensure continuity of cardiac rehabilitation services where important clinical support services are not available for the reasons identified in the report (i.e. maternity leaves, retirements, transfer of staff, etc). Similarly, it is anticipated that demand for cardiac rehabilitation services will continue to grow requiring all units to be ableit's what men do."

They have a wealth of pitching but as of right now they have two guys considered top of the rotation guys and a whole lot of power arms that are seen as third starters or pen arms.

That's fair, but they did just graduate a TORP. And other teams don't have an abundance of them. I think its a bit of an oversight from my perspective.

"You don't know how to drink. Your whole generation, you drink for the wrong reasons. My generation, we drink because it's good, because it feels better than unbuttoning your collar, because we deserve it. We drink because it's what men do."

Just want to add one thing about Callis.
He was asked to ranked 1st basemen after the 2009 season, He had Smoak


court has determined that this opinion should not
be published and is not precedent except under the limited circumstances set forth in 5TH CIR.
R. 47.5.4.
                                  No. 08-30471

            I. FACTUAL AND PROCEDURAL BACKGROUND
        On September 12, 2005, shortly after Hurricane Katrina, Singleton
attempted to visit the Wal-Mart store located in Boutte, Louisiana. For security
reasons, the store limited the number of customers allowed inside at a given
time, resulting in lengthy lines waiting to enter. Singleton dropped off his wife
and granddaughter atclaims. The district court dismissed the § 1981 claim
because Singleton failed to show interference with a contract interest, it
dismissed the § 1983 claim because Singleton could not show state action, and
it dismissed the § 1985 claim because Singleton presented no evidence of a
conspiracy to deprive him of a protected federal right. Thereafter, the district
court granted summary judgment in favor of the officers, finding that they did
not violate any of Singleton’s constitutional rights on September 12, 2005, and
that there was probable cause for the arrest on September 20, 2005.1
                                    II. DISCUSSION


           i. Singleton’s § 1981 claim

       1
         In this same order, the district court dismissed Singleton’s remaining state law claims
for lack of subject matter jurisdiction after all federal claims had been dismissed. Singleton
has not challenged this portion of the order on appeal.

                                               3
               Miguez, Roth, and Olivier
       After the district court granted the motion for summary judgment of Wal-
Mart and Howard, Miguez, Roth, and Olivier filed a separate motion for
summary judgment based on the defense of qualified immunity.4 The district
court granted the motion, concluding that Singleton had not established that
Miguez or Roth violated any of his constitutional rights during the incident on
September 12, 2005, and that Olivier had probable cause to arrest Singleton on
September 20, 2005, after he refused to leave the premises.
       We agree that Miguez and Roth’s actions on September 12, 2005, were
protected by qualified immunity. Qualified immunity protects government
officials performing discretionary functions from civil liability if their conduct
does not violate clearly established statutory or constitutional rights


Mr Assad about where some treasures were hidden.

Some reports say that he was executed after refusing these requests.

Historian and writer Tom Holland said if the reports were true, Mr Asaad was "not just a martyr, but a hero.decision not to ratify the bill on sending troops,” Interfax quoted her as saying. Deputies had heated discussions in the parliament’s committees, the deputy said.Now that the US is considering withdrawing its troops from Afghanistan, it would be unacceptable for Astana to send servicemen after refraining for so long, Dzhalmagambetova noted. The move would tarnish the country’s reputation as a peaceful state, she believes. Another senator, Tasbay Simambaev, said during the meeting that Kazakhstan had all the grounds to reject the ratification. The country should maintain a balanced foreign policy and neutral position, he stressed. Public opinion was also against the agreement with NATO, he said. As Kazakhstan enjoys an internal stability, the country was shocked by two bombings in May. In the first case, a resident of


they stood before the officer, undoubtedly with heart in throat, wondering if anything they said might provide an excuse to send them back whence they came.

Whoever looked at my grandmother, Lisi, when she arrived on the evening of September 26th, 1911, began filling in the twenty-nine columns on line 19 of the manifest with the details that the U.S. wanted to know about this "alien" prior to her entry into this country.

Line 19 of manifest for the steamer, Kaiser Wilhelm II

Columns 1and 2 -- her full name: Ebner, Erzsebeth (see detail, above)

Never mind what her real name was. They took the Hungarian equivalent, Erzsebeth, from her passport/Dienstbuch [for details of this dual-purpose document, see 6/14 post, When a Resume Worked as a Passport)

The mistaken transcription

Years later, when allcode, since CLDR includes additional countries
     * for addressing purposes, such as Canary Islands (IC).
     *
     * @return string The two-letter country code.
     */
    public function getCountryCode()
    {
        return $this->countryCode;
    }

    /**
     * Gets the locale.
     *
     * Only defined if the country has a local format.
     *
     * @return string|null The locale, if defined.
     */
    public function getLocale()
    {


    return $this->locale;
    }

    /**
     * Gets the format string.
     *
     * Defines the layout of an address, and consists of tokens (address fields
     * prefixed with a '%') separated by unix newlines (\n).
     * Example:
     * <code>
     * %givenName %familyName
     * %organization
     * %addressLine1
     * %addressLine2
     * %locality %administrativeArea %postalCode
     * </code>
     *
     * @return string The format string.
   of address fields.
     */
    public function getRequiredFields()
    {
        return $this->requiredFields;
    }

    /**
     * Gets the list of fields that need to be uppercased.
     *
     * @return array An array of address fields.
     */
    public function getUppercaseFields()
    {
        return $this->uppercaseFields;
    }

    /**
     * Gets the administrative area type.
     *
     * Used for presenting the correct label to the end-user.


of predefined subdivisions.
     *
     * Note that a country might use a subdivision field without having
     * predefined subdivisions for it.
     * For example, if the locality field is used by the address format, but
     * the subdivision depth is 1, that means that the field element should be
     * rendered as a textbox, since there's no known data to put in a dropdown.
     *
     * It is also possible to have no subdivisions for specific parents, even
     * though the country generally has predefined subdivisions at that depth.
    *
     * @return int The subdivision depth. Possible values:
     *             0: no subdivisions have been predefined.
     *             1: administrative areas.
     *             2: administrative areas, localities.
     *             3: administrative areas, localities, dependent localities.
     */
    public function getSubdivisionDepth()
    {
        return $this->subdivisionDepth;


circulating intestinal bacterial products, may promote synovial inflammation ([@B32]; [@B24]; [@B45]; [@B48]), a causal relationship between bacterial infection and onset of rheumatological diseases has not yet been firmly demonstrated. Further studies on leaky gut syndrome could clarify the presence of bacterial products circulating and influencing the systemic immune response, also in light of the presence of bacteria in non-rheumatoid arthritis controls ([@B32]), and of potential microbial contamination found in amplification technique of 16S rDNA, as previous observed ([@B28]).

A targeted-metagenomics approach can provide an in-depth characterization of microbial communities, allowing investigation of correlations between microbiota composition and human pathologies ([@B43]).

In this study, we characterized and compared the gut microbiota of JIA patients, affected by enthesitis-related arthritis (JIA-ERA) and polyarticular JIA (non-enthesitis-related arthritis, nERA), with healthy subjects (HS), in orderidentifiers, we obtained the final output from metagenome prediction as an annotated table of predicted gene family counts for each sample, where the encoded functions of each gene family are orthologous groups or other identifiers such as KEGG orthologs (KOs). The functional pathways discovery and related statistical significance were assessed by LEfSe.

Results
=======

Clinical Features of JIA Patients
---------------------------------

We collected clinical features, as well as comorbidities and therapies, for each enrolled patient at the time of fecal sampling (**Table [1](#T1){ref-type="table"}**; more details in Supplementary Tables [S1](#SM1){ref-type="supplementary-material"} and [S2](#SM1){ref-type="supplementary-material"}). As known, due to the two different subsets of JIA, females are affected from polyarticular JIA two to four times more often than males ([@B48]). In our cohort, most of the enrolled JIA-ERA patients were males (13/19), while all JIA-nERA patients were females


import inspect
import io
import json
import logging
import os
import sys

import six

def ensure_path_exists(path):
    path = os.path.expanduser(path)
    if not os.path.exists(path):
        os.makedirs(path)
    return path

logger = logging.getLogger(__name__)

class ConfigurationRegistry(object):

    def __init__(self):
        self._register = {}

    def register(self, key, description=None, default=None, onchange=None, onload=None,
                 type=None, host=None):
        """
        Register a configuration key that can be set by the user. As noted in the
        class level documentation, these keys should not lead to changes in  a signature accepting one variable).
         - onload* : A function of no arguments to call to initialize the value
            of this configuration setting
         - type : Values set will be of `isinstance(val, type)`

        * If not specified, these fields default to None.
        """
        if key in dir(self):
            raise KeyError("Key `{0}` cannot be registered as it conflicts with a method of OmniductConfiguration.".format(key))


as well as
        their current values, descriptions and the module from which they were
        registered.
        """
        for key in sorted(self._register.keys()):
            desc = self._register[key].get('description')
            if desc is None:
                desc = 'No description'
            val = str(self._config.get(key, '<Not Set>'))
            print('{0} = {1} (default = public function __construct($definition) {
        $this->conf = $definition->defaults; // set up, copy in defaults
        $this->def  = $definition; // keep a copy around for checking
        $this->parser = new HTMLPurifier_VarParser_Flexible();
    }

    /**
     * Convenience constructor that creates a config object based on a mixed var
     * @param mixed $config Variable that defines the state of the config
     *                      object. Can be: a HTMLPurifier_Config() object,


   *                      an array of directives based on loadArray(),
     *                      or a string filename of an ini file.
     * @param HTMLPurifier_ConfigSchema Schema object
     * @return Configured HTMLPurifier_Config object
     */
    public static function create($config, $schema = null) {
        if ($config instanceof HTMLPurifier_Config) {
            // pass-through
    */
    public function getHTMLDefinition($raw = false) {
        return $this->getDefinition('HTML', $raw);
    }

    /**
     * Retrieves object reference to the CSS definition
     * @param $raw Return a copy that has not been setup yet. Must be
     *             called before it's been setup, otherwise won't work.
     */
    public function getCSSDefinition($raw = false) {
        return $this->getDefinition('CSS', $raw);
    }

    /**


/**
     * Returns a list of array(namespace, directive) for all directives
     * that are allowed in a web-form context as per an allowed
     * namespaces/directives list.
     * @param $allowed List of allowed namespaces/directives
     */
    public static function getAllowedDirectivesForForm($allowed, $schema = null) {
        if (!$schema) {
            $schema = HTMLPurifier_ConfigSchema::instance();
        }
        if ($allowed !== true) {
             if (is_string($allowed)) $allowed = array($allowed);
  HTMLPurifier_ConfigSchema to use, if not global copy
     */
    public static function loadArrayFromForm($array, $index = false, $allowed = true, $mq_fix = true, $schema = null) {
        $ret = HTMLPurifier_Config::prepareArrayFromForm($array, $index, $allowed, $mq_fix, $schema);
        $config = HTMLPurifier_Config::create($ret, $schema);
        return $config;
    }

    /**
     * Merges in configuration values from $_GET/$_POST to object. NOT STATIC.
     * @note Same parameters as loadArrayFromForm
     */
    public function mergeArrayFromForm($array, $index = false, $allowed = true, $mq_fix = true) {


Story highlights The task force is being led by Rep. Seth Moulton, a Marine Corps veteran

National security has made Democrats vulnerable in recent special elections

(CNN) Sensing an opening on national security issues, House Democrats are launching a new effort to counter President Donald Trump's foreign policy.

A trio of junior lawmakers with military and Pentagon experience will announce on Tuesday the formation of a new national security task force to push back on policies coming from congressional Republicans and the White House.

The task force is being led by Rep. Seth Moulton of Massachusetts, a Marine Corps Iraq veteran who has received some early 2020 presidential buzz.

It's both an outlet for out-of-power Democrats to showcase their ideas, as well as a recognition that Democrats continue to search for an effectivean input back to R via Shiny.onInputChange("marker", inputs[0].checked); ) --> This will produce the desired "input$marker".
However, this function only fires once, which is totally right behaviour. But you wont have updates when you click the button.
Challenge 4: Update input$marker
Well the pretty version would be to have a function .onclicked()/ a listener for the input. Maybe somebody could find a solution. I tried a workaround in shiny, that i tell shiny to constantly get value of the input via autoInvalidate().
Challenge 5:
Well, not that difficult, because it is shiny only, but for sake of completeness. Given the provided code in the question, the marker will stay when loaded once. Not sure if you want it to stay or to be removed once your zooming criteria is not met.
Anyway,


This is Scotch Tape, a series of people with their faces all wonked up with scotch tape by photographer Wes Namen. I don't know what these people looked like before, but they are lookin' fine as hell now. Take this first girl -- she may have only been a four before, but now? A solid eight. "Tell me you're joking." Jesus, of course I'm joking. An eleven...ON THE RICHTER SCALE. Apocalyptic hotness. One time I got my face all taped up but it turns out I was being kidnapped.

Hit the jump for a bunch more but be sure to check out the photographer's site for even more more.

Thanks to PYY, who agrees it's what on the inside that counts. I just ate a Hot Wheels!

Handy Latin Phrases Non calor sed umor est qui nobis incommodat.

It's not the heat, it's the humidity. Di! Ecce hora! Uxor mea me necabit!

God, look at the time! My wife will kill me! Estne volumen in toga, an solum tibi libet me videre?

Is that a scroll in your toga, or are you just happy to see me? Lex clavatoris designati rescindenda est.

The designated hitter rule has got to go. Sentio aliquos togatos contra me conspirare.

I think some people in togas are plotting against me. Caesar si viveret, ad remum dareris.

If Caesar were alive, you'd be chained to an oar. Quantum materiae materietur marmota monax si marmota monax materiam possit materiari?

How much wood would a woodchuck chuck if a woodchuck could chuck wood? (At a barbeque)

Animadvertistine, ubicumque stes, fumum


went on strike was that the train behind mine had jumped
the rails on a bridge, landing in a ravine, and killing most people on board.
Yet, I was still alive.

I decided
that I would fly home to Los Angeles and called my parents to let them know
that I was safe and would take the safer option back home. After visiting
museums and climbing pyramids, I got out to the airport and boarded the flight
on Mexicana de Aviation airways. We took off. Not long thereafter, about
twenty minutes only, the prerecorded announcement came over the loudspeakers
“Please prepare for landing at Los Angeles International Airport.” Impossible.

The
hydraulics on the plane had gone out. We were making an emergency landing in
Guadalajara, at night, at a closed airport, without radar, in the middle of
torrential rainstorm. Again, Ithe pilot, we collected 1247 pounds of blue wrap (32 lbs collected daily). The cost of the pilot was $14 987 that includes a new baler ($11 200) and 5 transport carts ($3697). The revenue received from baled blue wrap was 8 cents per pound. Cost avoidance yielded $31 680.00 in savings. Implementation of this pilot across our main hospital would yield $5000 in revenue annually and $174 240 in cost avoidance. This project can be replicated at other centers and not only reduces the environmental footprint, but also helps generate additional revenue by recycling a necessary packing material that would otherwise require payment for disposal.


strip from which the strip is hung. Those hook-like portions are inserted through the openings in a multiplicity of the product enclosures so that portions of those product enclosures are engaged between the hook-like portions and a portion of the strip from which those portions project. Product enclosures containing products are typically attached to the polymeric strips at the manufactures packaging facilities and are sent on the strips to the place at which the products in the product enclosures are displayed. Each polymeric strip and the product enclosure attached to it are typically sent to that place in a five panel corrugated fiberboard folder of the type illustrated at page 25 in a book entitled "Fibre Box Handbook" bearing a 1992 copyright and available from Fibre Box Association,conducted in February 2010 by the Human Resources Professionals Association in partnership with Workopolis through an online poll of 1,022 HRPA members. The Harris/Decima study was conducted via teleVox, the company's national telephone omnibus survey, with a representative sample of 1,095 working Canadians between April 22 and May 2, 2010. It has a margin of error of +/- 3.0 percent, 19 times out of 20.


agreement with our previous observations and confirms the concept of chemotherapy with rational molecular bases.

Conclusion
==========

Our results show that the MG132 proteasome inhibitor can sensitize U937 leukemic cells to the toxic action of DOX with a greater apoptotic tendency.

Methods
=======

Cells
-----

We employed the cell line U937 (ATCC CRL-1593.2) that is derived from human monocytic leukemia. These cells were maintained under cryopreservation and cultivated in Roswell Park Memorial Institute (RPMI)-1640 medium (GIBCO, Invitrogen Corp., Carlsbad, CA, USA), to which we added 10% Fetal bovine serum (FBS) (GIBCO), L-glutamine to a final concentration of 2 mM (GIBCO), and antibiotics (GIBCO), which will be designated RPMI-S. Cells were maintained at 37°C in a humid atmosphere containing 5% CO~2~ and 95% air.

Drugs
-----

DOX was obtained from Pisa Laboratories, México and stored at −4°C for use inh, morphological changes were observed and cells were harvested and apoptosis, caspase cleavage or activity, ΔΨm loss, senescence, and Bcl2- and Bcl-XL antiapoptotic proteins were determined. *p65* phosphorylation was analyzed 1 h after treatment with DOX or with MG132. For the gene-expression study, cells were incubated for 3 h with the drugs. For viability determination, U937 cells were reseeded in 96-well plates, and 2 × 10^4^ cells were treated with DOX, MG132, or both; viability was measured at 18, 24, 36, and 48 h of culture and proliferation at 72 h. Concentrations of the treatments employed in this study were previously confirmed as being the most favorable for the induction of apoptosis in this experimental model \[[@B7]\].

Morphological changes in U937 treated with MG132 or Doxorubicin
---------------------------------------------------------------

U937 cells were treated with the


Oligo ver.6 software. Gene sequences were obtained from the GenBank Nucleotide Database of the National Center for Biotechnology Information (NCBI) (<http://www.ncbi.nlm.nih.gov>).

Statistical analysis
--------------------

All of the experiments were performed in triplicate and were repeated three times. The values represent the mean ± SD of the values obtained. Statistical analysis was carried out with the non-parametric Mann--Whitney *U* test, considering *p* \<0.05 as significant. In some experiments, we calculated the ∆%, which represents the percentage of increase or diminution in relation to the non-treated control group. For the different genes, significant variation was considered at ≥30% compared with that of the constitutive genes.

Competing interests
===================

The author declares no potential conflict of interests.

Authors' contributions
======================

PCO-L, AB-C, and GH-F designed and performed the research, analyzed the data, and drafted the manuscript; JML-D, JRD-R, PG-L, OG-R and RC-Cpinch points that leave almost no room for both a cyclist and motorist. When it came time to re-stripe PCH, we contacted Cal-Trans and were able to speak directly to the lead engineer on the project. We introduced ourselves, and the club that we represent, as cyclists who are intimately aware of the hazards of PCH and asked if a three foot space could be striped off near the Bel-Air Bay Club, one of the more dangerous pinch points on the southbound side of the road. They reviewed our suggestions and today, a three foot wide space exists where no space existed before.

ABT: Best area to ride in LA?

MF: The hills above Malibu; probably the closest place to LA where you can feel like you’re tackling a Tour


dieticians upon visiting their local GP offices every three months. The curricula by the dieticians were developed centrally. In terms of lifestyle and nutritional modification, patients received a 30-minute session from a registered dietician. Prior to every session, the dietician checked the patient's condition using a checklist as shown in [S2 Fig](#pone.0151422.s002){ref-type="supplementary-material"}. Every checklist item had a score; the higher the score, the further the treatment target. The dietician decided on the dietary counseling theme depending on the score. Registered dieticians provided lifestyle/dietary advice according to the instructions. They helped patients to achieve their CKD treatment goals ([S1 Table](#pone.0151422.s004){ref-type="supplementary-material"}), explained the examination results, achievements in CKD care, and their implications to patients. The registered dieticians had received training so that they would be able to provide integrated andconsistent advice. Secondly, the group B patients received a CKD treatment report from the coordinating center bimonthly to learn about CKD and their ideal lifestyle to prevent progression. In addition, the patients also received a letter, phone call, or email a week before the consultation day, and those who had not consulted a physician for over two months were encouraged to receive care, as an attempt to prevent their withdrawal from treatment. Thirdly, the group B GPs received comments about their patients' data, focusing on the gap between target and practice, from the coordinating center. The coordinating center also provided information on the patients scheduled to visit the office, examinations, treatment patients should undergo on their next visitation, patients who did not visit hospitals as scheduled, those who


\[[@pone.0151422.ref033]\]. There are few interventional clinical studies of CKD patients cared for by GPs, and there is also little information about the detailed clinical outcome and treatment pattern changes in recent years at GPs. A long-term follow-up of this subject would be also valuable.

In conclusion, an advanced CKD care system could achieve behavior modification of CKD patients, namely, significantly lower discontinuous clinical visit rates, and behavior modification of both GPs and nephrologists, namely, significantly higher referral and co-treatment rates, resulting in the retardation of CKD progression, especially in patients with proteinuric Stage 3 CKD. For the purpose of lifestyle modification for preventing the progression of kidney dysfunction and complications, this type of multifactorial intervention might be one solution.

Supporting Information {#sec028}
======================

###### Distribution of clinical sites in Japan.

(DOCX)

######

Click herefor the work on the anti-aircraft firing center at Camp Davis.
13. When the work began it was discovered that the camp site was largely swampy ground, and it was necessary to use large quantities of sand and sand clay as a stabilizer. Only a small quantity of such material was found on the site, all of which was used. When it became apparent that large quantities of sand and sand clay would be required in the performance of the work, the contractor's project manager, Mr. Street, discussed with Colonel Montgomery the method to be employed in securing the material. It was decided that the cheapest, quickest and most efficient method to secure the material was to place purchase orders for its delivery on the site. Objection was raised


the unfilled balance of these purchase orders was canceled. Deliveries and payments for the material were as follows:

P. O. 197, sand clay, 349,854
  cu. yds. @ $1.00 .............. $349,854.00
P. O. 903, sand clay, 58,868 cu.
  yds. @ $0.75 ..................   44,151.00
P. O. 803, sand, 299,800 cu. yds.
  @ $0.50 .......................  149,900.00
P. O. 1103, sand, 195,646 cu.
  yds. @ $0.475 .................   92,931.85
                                  ___________
     Total ......................  636,936.85

17. On February 11, 1941, the purchasing agent for Grannis, Higgins, Thompson & McDevitt Company issued a purchaseorder to F. N. Thompson, one of the four contracting parties, for the furnishing of B and C grade local sand for sand asphalt at a price of 88 cents per ton. This material was to be delivered to the plant or plants on the site and payment was to be made on the basis of the per ton mix in the asphalt plant. This purchase order was approved by the constructing quartermaster. On May 29, 1941, this purchase order was terminated. Delivery and payment was as follows: 53,379 tons at 88 cents: $46,973.52.
18. The unit prices set forth in the purchase orders to Grannis and Thompson were reasonable prices for delivery on the *762 site. Grannis and Thompson submitted invoices to the contractor for the material delivered,