     if (!FLAG_video && media_type == MediaType::VIDEO)
        continue;
      if (!FLAG_data && media_type == MediaType::DATA)
        continue;
      if (strlen(FLAG_ssrc) > 0) {
        const uint32_t packet_ssrc =
            webrtc::ByteReader<uint32_t>::ReadBigEndian(
                reinterpret_cast<const uint8_t*>(packet.data + 8));
        if (packet_ssrc != ssrc_filter)
          continue;
      }

      rtp_writer->WritePacket(&packet);
                 print(f"The request was invalid\nStatus code: {response.status}")

The website I am looking for is "https://rubyrealms.com/user/{input}/" where input is given while running h!rubyinfo USERNAME changing the link to https://rubyrealms.com/user/username/.
On the website what  I want to get is their BIO which has an XPATH of

"//*[@id="content-wrap"]/div[3]/div[3]/div/div[2]/div[1]/div[2]/div/p"

where the element is:
<p class="margin-none font-color">
Hey! My name is KOMKO190, you maybe know me from the forums or discord. I am a programmer, I know a bit of JavaScript, small portion of C++, Python and html/css. Mostly python. My user ID is 7364. ||| 5th owner of Space Helmet :) </p>

Any help on how I would scrap that? The only response my bot gives is "[]"

A:

Change your XPath expression for a relative one


the votes to secure our Country, the Military will build the remaining sections of the Wall. They know how important it is!

Charles Ashby at the Grand Junction Sentinelreports, the controversy over a bizarre case of a legislative candidate allegedly faking their residency in the district in question, compounded by allegations of intimidation, is complicating GOP Rep.-elect Matt Soper’s ascension to House District 54:

The complaint, filed by Palisade resident David Edwards, claims Soper may not have actually lived in House District 54 for the required 12 months prior to being elected to the seat last month.

“Soper’s only other voting registration address was also in Orchard City, Colorado, in House District 61,” Edwards writes in the complaint. “It is easy to assume that, in fact, Soper’s domicile continued to bebuilt-in, ICSA-certified WAF, Thunder ADC guards vulnerable software from dozens of application layer attacks, including the Open Web Application Security Project (OWASP) top-10 threats. These attacks include cross-site request forgery, SQL injection and buffer overflows that target coding flaws. Integrated into Thunder ADC, the WAF blocks these and other application behavior anomaly attacks, as well as prevents unauthorized data leakage.

A WAF filters all application access, inspecting both the traffic towards the web application and the response traffic from the application. By securing both the application infrastructure as well as the application user, a WAF complements traditional network firewalls, which are not designed to protect at this granular level.

Threat Vectors

Applications can be vulnerable to many threats that are not detected by regular network firewalls. The impact of these attacks


\[[@CR17]\]. The fat mass was then calculated using an assumed fat density of 0.923 kg/L \[[@CR30]\].

The total abdominal fat was defined as all fat within the fixed abdominal region. The visceral fat volume (V) was defined as fat within the intra-abdominal compartment of the peritoneal and retroperitoneal cavities. The circumferential boundaries of the intra-abdominal compartment were traced as free-hand ROIs along the ventral aspect of the included vertebrae, the inner surface of the included rib cage, the ventral margin of the lumbar hypaxial muscles, the visible peritoneum, and the inner boundaries of the rectus abdominis muscle and transversus abdominis muscle. This was modified from previous descriptions in dogs and humans, as the lumbar hypaxial musculature was excluded from the visceral compartment in this study \[[@CR19], [@CR26], [@CR31]\]. The ROIsComments: 1971 AARS winner. Considered by many to be one of the very best grandiflora roses, 'Aquarius' flowers freely from spring until frost, producing small sprays of up to five double blooms that are lightly fragrant. Foliage is large and leathery. Blooms in flushes throughout the season. Plants are urn shaped, upright, and vigorous. They are well suited to beds and borders, and flowers are ideal for cutting. This rose is extremely disease resistant.


knowledge. Neither party knew that Newmont had actually discovered a valuable deposit on Abe 11. Horn did know that he could make no realization from his interest in the Abe claims unless the properties were worked by lease or otherwise; that the assessment work upon the claims had to be done within forty days; that Daniel could only want the Abe claims for the purpose of leasing and could only want Horn's interest in order to obtain a greater interest than could be obtained by a joint leasing; and that Newmont was interested in obtaining a lease. By August 1957 Horn had both been informed by Daniel that Newmont had a lease on the Abe properties and had witnessed the operations of the company on the ground. He     66
  Age at surgery, mean (SD) in years       48 (12)
  Sex, n (%) female                        39 (59)
  Bilateral otosclerosis, n (%)            35 (53)
  Preoperative CT scan, n (%) yes          49 (74)
  Previous surgical technique, n (%)
   Stapedotomy


Things seem to have reached Desperation O'Clock in Greece, where Prime Minister Alexis Tsipras is now seeking a referendum as a way to avoid a choice between agreeing to the kind of austerity budget he promised to avoid and the Greek exit from the eurozone that he also promised to avoid. For the latest developments, you should probably check a dedicated financial news service like the Wall Street Journal, or Bloomberg. For a sophisticated and well-informed account of what Greece's European partners have done wrong, you should read Karl Whelan. For an analysis of the specifics of Tsipras' gambit, you should read Hugo Dixon.

But to understand the deeper causes of what's been going on since Tsipras' government swept to power in January, you really need to set the
Ask HN: Can genetic algorithm get “sick”? - tuxlinuxien
ok, my question might be stupid but I was wondering if my genetic algorithm get "sick", how can I find a cure for it?
======
dwils098
By sick, you mean can it become bias to a subspace in the solution space, if
so you would "cure" it by re-defining your fitness function to not get
"stuck", or fooled by a local maxima.

------
crazypyro
I don't understand what you mean by "sick". There are a few different ways a
genetic algorithm can "fail to converge" though (or converges on a solution
that is not a global maxima).

This could be caused by having too high of a diversity, causing the algorithm
to give up on promising avenues of evolution too early.

Another risk is having too high of selective pressure, causing the algorithm
to


         echo '<p>' .$singlepost->music_id. '</p>';
              }
            ?>

A:

Use $wpdb->get_col. It will return a one-dimensional array that you can use in    post__in
$allposts = $wpdb->get_col("SELECT `music_id` FROM `custom_table` ORDER BY id DESC LIMIT 5");

trying to push him out, they would need to demonstrate his work through either paper, video, demonstration etc.

http://www.qcda.gov.uk/curriculum/sen/6058.aspx

In the school I worked in, which was an SLD/ PMLD school, we had children (well, 2 children) who worked up as far as NC3 in some areas, but those scores alone do not fit someone for mainstream - other difficulties, either ASD or physical, meant that these kids were better with us.

I found a document on my LA's website that detailed the P scales I mention; it seems Essex use those specific ones when applying for a Statement (which DS1 already has). It doesn't have a breakdown of what they are, assume they have a scoring sheet squirreled away. It does state on that document that for Foundation stage P


Sorcey - Responsive One Page Parallax HTML Template

Sorcey - Responsive One Page Parallax HTML Template

Sorcey – Responsive One Page Parallax HTML Template is a clean and modern Onepage Parallax HTML Template built with Bootstrap framework. This is a trendy creative template for your Business website, Agency or Startup. It looks perfect on all major browsers, tablets and phones. It is ultimate flexible with loads of nice options and features. Every single detail is carefully designed and crafted in order to create a seamless and wonderful user experience.
Just take the best Template of your choice, change the text, add your images and done!. Take a look at this wonderful HTML template pages and you will be impressed even more! Enjoy!want to say to you, my brethren, that the time is coming when we will be mixed up in these now peaceful valleys to that extent that it will be difficult to tell the face of a Saint from the face of an enemy against the people of God. Then is the time to look out for the great sieve, for there will be a great shifting time, and many will fall. For I say unto you there is a test, a Test, a TEST coming. This Church has before it many close places through which it will have to pass before the work of God is crowned with glory. The difficulties will be of such a character that the man or woman who does not possess a


RAIL Back On Track is conducting a survey of how public transport passengers rate our public transport in south-east Queensland. Everyone who travels on public transport in south-east Queensland is invited to participate. Also anyone who avoids using public transport can also comment as to why they do not use public transport.

Since RAIL Back On Track formed in 2006 we conducted our own annual member surveys on how members rate public transport. Since 2011 we have opened our survey up to the public. Previous surveys can be found here > https://railbotforum.org/mbs/index.php?board=46.0

The survey is web based and all public transport passengers on the TransLink network in south-east Queensland are welcome to complete it. The survey is anonymous and quick to complete.

The information from this survey will be used tohas climbed from 12.5 per cent in 2015 to 48 per cent.

“These are people who regularly travel on trains. It’s a fairly disastrous outcome for rail. Light rail is the standout performer,” Mr Dow said.

Commuters called for more express runs from Beenleigh to the city, saying it was faster to travel by bus.

“The fares are too high. It’s cheaper to fuel my car and drive to work than it is to catch the train. That is just crazy,” a resident wrote.

Mr Dow said the Government was close to getting a better fare system, but the length of the trip to Brisbane remained a turn-off for Coast residents, along with the frequency of cancellations.

“It is beyond ludicrous that it sometimes takes over two hours on a train and a


maintained. In major depression, feelings of worthlessness and self-loathing are common.

For some people, the death of a loved one can bring on major depression. Losing a job or being a victim of a physical assault or a major disaster can lead to depression for some people. When grief and depression co-exist, the grief is more severe and lasts longer than grief without depression. Despite some overlap between grief and depression, they are different. Distinguishing between them can help people get the help, support or treatment they need.

Risk Factors for Depression

Depression can affect anyone—even a person who appears to live in relatively ideal circumstances.

Several factors can play a role in depression:

Biochemistry: Differences in certain chemicals in the brain may contribute to symptoms of depression.

Differences in certain chemicals in thedepression. For many people, regular exercise helps create positive feeling and improve mood. Getting enough quality sleep on a regular basis, eating a healthy diet and avoiding alcohol (a depressant) can also help reduce symptoms of depression.

Depression is a real illness and help is available. With proper diagnosis and treatment, the vast majority of people with depression will overcome it. If you are experiencing symptoms of depression, a first step is to see your family physician or psychiatrist. Talk about your concerns and request a thorough evaluation. This is a start to addressing mental health needs.

Related Conditions

References

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5), Fifth edition. 2013.

National Institute of Mental Health. (Data from 2013 National Survey on Drug Use and Health.) www.nimh.nih.gov/health/statistics/prevalence/major-depression-among-adults.shtml

Kessler, RC, et al.


Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593602. http://archpsyc.jamanetwork.com/article.aspx?articleid=208678

Physician Review By:

Ranna Parekh, M.D., M.P.H.

January 2017innocent request for Sencha to consider the potential that TypeScript provides for static tooling.

TypeScript
I just spotted TypeScript (http://www.typescriptlang.org/), and it
  looks promising. Has anybody had a chance to play around with it yet?
  I want to understand if it would be possible to produce a TypeScript
  declaration file to declare all the types from the Ext JS and Sencha
  Touch frameworks. I'd love to have better static analysis and tool
  support for my Sencha development work.
Thanks!

This is the response from a Sencha Senior Forum Manager:

Just another thing to make things ugly [TypeScript]
[EDIT] Regardless of how many times I say this comment was obviously a
  personal comment, it's still personal. If you haven't talked to me or
  followed me on Twitter


when adding in the additional machinery required for inheritance, it is the pattern used by ES6 to define the notion of a class. Therefore, it is the pattern used by the TypeScript compiler to compile a class.
For a more complete treatment of this form of classical object-oriented programming in JavaScript, along with techniques for making classical inheritance more succinct, see this post by Douglas Crockford.
What's noteworthy is that the notion of a type exists only at design time, and is enforced by the TypeScript compiler to help you write sturdier code.
ExtJS
Before TypeScript existed, I had become familiar with the model of classical inheritance employed by Sencha's ExtJS framework. This model provides a means for defining classes and creating instances from their corresponding types using several patterns,discovering TypeScript (version 0.8), my initial reaction was to create a type definition file for classical, which would be a similar (but much simpler) endeavor to creating one for ExtJS. After I had completed this task, the syntax of the resulting library was an utter disaster! I'd like to explore what went wrong, and I'll do so with a simple example from ExtJS.
This code is taken from the discussion mentioned above, and looks like a standard ExtJS class definition:
Ext.define('WebApp.model.RenderableRecord', {
    extend: 'Ext.data.Model',
    idPropert: 'id',

    isRenderableRecord : true,

    fields: [
        { name: 'id', type: 'string' },
        { name: 'name', type: 'string'


Review Sections

When I told my colleagues I had just gotten an M3 in for review, they looked all jealous and rushed down to the garage to check it out. But rather than BMW's legendary weekend racer, I was talking about EcoReco's M3, an electric scooter. Unlike the Beemer, the M3 E-Scooter runs on electricity, can fold up for easy storage, and gets up to only 20 mph.

Design and features

Similar to the types of scooters Razor repopularized in 1999, the M3 E-Scooter consists of a wheeled deck and steering column with handlebars. Instead of foot power, however, the deck contains a lithium-ferrophosphate battery pack which powers a 250-watt electric motor in the rear hub.

The structural pieces of the M3 E-Scooter are made from thick aluminum, giving the scooter aViola Jokes

Part 1

These jokes have enjoyed wide publicity. They have been mentioned in such places as Alex Beam's Boston Globe column on Wednesday, November 30, 1994 (p. 65), John Hayward-Warburton's article in BBC Music , and Dave Barry's book Dave Barry in Cyberspace (pp. 153-4).

Acknowledgement

These jokes are a continually-growing collection, and unfortunately, I can no longer remember which jokes I heard from whom. If you have ever told, emailed, or otherwise communicated to me a music joke, thank you.

I also collect Jokes about other instruments.

How is lightning like a violist's fingers? Neither one strikes in the same place twice. How do you keep your violin from getting stolen? Put it in a viola case. What's the difference between a violin and a viola? The viola burns longer. The


based on the configuration of the system. For example, the number of characters you store in a database is different from the number of bytes of space it takes up. In a character set like Latin-1 (ISO-8859-1), all available characters can be stored in a single byte, but because UTF-8 includes a vastly larger range of characters, it might take up to 4 bytes (as of MySQL 5.6, MySQL will use up to three bytes) to do so. The differential will not be significant for Western European languages, but would be radically so if your database contained Chinese characters for example.
With MySQL, size limitations generally depend on the file system (which relates to the operating system). Since InnoDB tables can span multiple files, your db can be quite89 Misc.2d 510, 511, 391 N.Y.S.2d 966 (1977); Sard v. Hardy, 34 Md.App. 217, 239, 367 A.2d 525, 537 (1976), Aff'd on this point and reversed on other grounds, 281 Md. 432, 451, 379 A.2d 1014, 1026 (1977); Herrera v. Roessing, 533 P.2d 60, 61-62 (Colo.App.1975); Wilson v. Blair, 65 Mont. 155, 167, 211 P. 289, 293-94 (1922).

9
To hold as appellants urge in this case would be to elevate the deceased doctor's therapeutic reassurance of his patient to the status of a guaranty, made without contract or compensation and at the risk of absolute liability.  This does not make good sense, either medically or legally.  See Sard v. Hardy, supra, 281 Md. at 452-53, 379 A.2d at 1027; Herrera v. Roessing, supra, 533 P.2d at 61;


that Mrs. Garcia definitely did rely on the surgeon's assurances and did become pregnant and had an abortion.  This is true even though guarantees generally require reliance of a "substantial character," Restatement (Second) of Contracts § 90, comment b.  If the assurances were made it would be just to enforce them, for there was evidence that the surgeon did not make tests he could have made to ascertain whether the tubal ligation had been successfully performed.  Thus, I see no logical reason that the New York Court of Appeals would not apply this "flexible" doctrine, Id., in this case.  But the same factors which bear on whether any relief should be granted also bear on the character and extent of the remedy.  Id.,between the object image contained in the reference pattern and the object image contained in the corresponding pattern is determined based on a parameter obtained by subtracting the contrast difference component from the correlation parameter concerning the corresponding pattern. Therefore, it is possible to more accurately determine the identity between the object images.
Preferably, the identity-determining means calculates the contrast value indicative of the contrast of the reference pattern based on a difference between a luminance value indicative of a luminance of the object image contained in the reference pattern and a luminance value indicative of a luminance of a background portion within the reference pattern, and calculates the contrast value indicative of the contrast of the corresponding pattern based on a difference between a luminance value indicative of


backup tackle.

Rookie Caleb Benenoch saw limited action but looked promising in his sole start against Chicago. He projects as a guard moving forward and could be the Bucs’ next utility lineman. Backup C Ben Gottschalk should be in consideration to start next season, provided a solid training camp. T Leonard Wester will have to fight to keep a backup role.

The Bucs are unlikely to make another big free agent move, not with so much money invested in the line already and considering Jason Licht’s preference for drafting linemen. If the Bucs were to pursue an expensive free agent, it has to be Bengals G Kevin Zeitler. While Cincinnati’s offensive line wasn’t very good last year, Zeitler is still one of the best guards in the league. The Bucscould cut JR Sweezy with only a $2.5 million cap hit and more adequately fill the void left when Logan Mankins retired.

While this year’s draft isn’t well stocked with quality offensive linemen, the Bucs do have options. At center, Ohio State’s Pat Elflein would be the Bucs’ best option to fill the center position. He’s not huge but he is nasty, qualities shared by current C Hawley. If he’s available in the third round, the Bucs have to pull the trigger.

There are no clear answers for what changes the Bucs need to make at offensive line where chemistry is nearly as important as talent. It’s never as simple as adding or moving pieces around. What is clear is that changes have to be made to improve the Bucs


extra subtitutions.  */
  char *ret = cplus_demangle_v3 (mangled, options);

  /* The Rust subtitutions are always smaller, so do in place changes.  */
  if (ret != NULL)
    {
      if (rust_is_mangled (ret))
	rust_demangle_sym (ret);
      else
	{
	  free (ret);
	  ret = NULL;
	}
    }

  return ret;
}

/* Demangle ada names.  The encoding is documented in gcc/ada/exp_dbug.ads.  */

char *
ada_demangle (const char *mangled, int option ATTRIBUTE_UNUSED)
{
  int len0;
  const char* p;
  char *d;
  char *demangled = NULL;

  /* Discard leading _ada_, which is used for library level subprograms.  */
  if (strncmp (mangled, "_ada_", 5) == 0)
    mangled += 5;

         if (strncmp (p, operators[k][0], slen) == 0)
                {
                  p += slen;
                  slen = strlen (operators[k][1]);
                  *d++ = '"';
                  memcpy (d, operators[k][1], slen);


century (Ludannyĭ, Khrisanfova, Prizenko, Bogeruk, & Semenova, [2010](#ece36286-bib-0025){ref-type="ref"}). A specific feature of this group is its adaptation to cold. To reach this characteristic, domesticated strains were bred with wild Amur carp (*C. carpio haematopterus*), which inhabits the Amur River on the Russian Far East, and their offspring underwent artificial selection for low‐temperature resistance. Here, we marked this domestic group as the Northern carp strain group based on its origin, even if some of these strains are now cultivated in southern regions of Russia (e.g., Stavropol and Ukrainian common carp strains).

Restriction site‐associated DNA sequencing (RAD sequencing) is a state‐of‐the‐art approach for genotype analysis, which has the advantages of next‐generation sequencing (NGS) technology for population‐wide studies with relatively low cost (Hohenlohe et al., [2010](#ece36286-bib-0011){ref-type="ref"}). A few modifications of the method have beenwere conducted by the Ape R package (Paradis & Schliep, [2019](#ece36286-bib-0031){ref-type="ref"}).

Admixture analyses of wild Amur carp to domestic common carp strains were performed with the NGSAdmix software (Skotte, Korneliussen, & Albrechtsen, [2013](#ece36286-bib-0036){ref-type="ref"}) setting the number of clusters (‐K parameter) to two.

2.4. Differential gene analyses {#ece36286-sec-0006}
-------------------------------

To estimate loci with differences in allele frequency between European and Northern carp strain groups, we selected specimens of domestic strains from VCF file, filtered by coverage (the loci with more than 10X coverage as minimum in 80% specimens), and imported them to the plink2 package (Chang et al., [2015](#ece36286-bib-0005){ref-type="ref"}) for logistic regression association statistics analysis. Loci (*p‐*value \<.05) were estimated for applicability to distinguish two *C. carpio* strain groups and then were selected for further analysis.

Genomic positions of the selected loci were intersected with gene


subsequent analyses.

The Hardy--Weinberg test has shown that 3,618 (from the 65,686) loci have a deviation from equilibrium in at least one strain or wild population---about 5% of deviated loci.

Dissimilarity matrix‐based reconstruction revealed clearly differentiated carp strain clusters, despite small distances between specimens (Figure [1](#ece36286-fig-0001){ref-type="fig"}). Generally, the two main strain groups can be distinguished in the clustering: Ponto--Caspian (European) cluster contains Poljana, Czech, Fresinet, and Tata strains as well as Volga, Ural, and Tisza wild common carp populations, while the Northern (mostly, Russian) strains form a separate group of strain branches in the dendrogram. This cluster contains Angelinskii, Cherepets, Ropsha, Ukrainian, and Stavropol strains.

![Cluster analysis of common carp performed on genome‐wide identity by state (IBS) pairwise distances. Blue font indicates specimens from the Northern strains, the European strains are shownGO categories in the down‐regulated gene set.

The identification of common genes with different allele frequencies in our study and differential expression with cold suggests that the cold tolerance mechanisms may be partly the same. However, genetic and epigenetic changes during adaptation do not have to be necessarily the same; for example, epigenetic regulatory changes can have a complementary action to compensate genetic variations (Artemov et al., [2017](#ece36286-bib-0001){ref-type="ref"}). Further investigations are required to comprehend the genetic mechanisms underlying trait formation and its possible hidden patterns of inheritance.

Our results provide insights into the genomic variability, population structure, and admixture events that occurred during domestication of common carp strains. In the work, we obtained molecular evidence, allowing to trace origin of Russian carp strains without any assistance of reference data as


The subject invention relates to a method and an apparatus for applying sealing material such as latex or adhesive to portions of flat or folded sneets, papers, bags, or the like, and more particularly to a method and apparatus for applying latex to the flap closure portion and the adjacent body portion of an envelope whereby when the latex portions are placed in overlapping relationship and pressure is applied, the envelope may be sealed.
It is to be understood that although the method and apparatus of the subject invention will be described with respect to the application of sealing materials, in general, it has particular application to a method and apparatus for the application of latex to an envelope flap and the cooperating portion of the envelope body inwith a pretreatment PSA level greater than or equal to 40 ng/ml relapsed and six (60%) developed rising PSA values. The differences were significant and were maintained when patients were stratified by stage or grade. (b) PSA level at 6 months: for patients with pretreatment PSA levels in the range 4-40 ng/ml, a 6-month value greater than 2 ng/ml predicted a significantly worse outcome than a 6-month value less than 2 ng/ml. (c) Rising post-treatment PSA values: following a radiation-related nadir in PSA levels, 24 patients experienced rising PSA values and 8 (33%) relapsed at a median time of 5 months after onset of the rising values--a significantly higher relapse rate than observed in patients with non-rising PSA values. Whether the majority, or all, of the patients with


Q:

Getting "Expecting a stackmap frame at branch target" when running Maven integration testing

I’m using Maven 3.2.3 with this version of Java
davea$ echo $JAVA_HOME
/Library/Java/JavaVirtualMachines/jdk1.8.0_45.jdk/Contents/Home

When I run
mvn clean install

I get errors like the below in my integration tests …
testFindSampleUsersByCodeAscByDefault(org.mainco.subco.user.service.SampleUserService2IT)  Time elapsed: 2.204 sec  <<< ERROR!
java.lang.VerifyError: Expecting a stackmap frame at branch target 57
Exception Details:
  Location:
    org/mainco/subco/user/service/SampleUserServiceImpl$ValueComparator.compare(Lorg/mainco/subco/user/domain/User;Lorg/mainco/subco/user/domain/User;)I @10: ifnull
  Reason:
    Expected stackmap frame at this location.
  Bytecode:
    0x0000000: 2ab4 001b 2bb9 002e 0200 c600 2f2a b400
    0x0000010: 1b2b b900 2e02 00c0 0030 b600 34c6 001c
    0x0000020: 2ab4 001b 2bb9 002e 0200 c000 30b6 0034
    0x0000030: b600 39b6 003e a700 0512 404e 2ab4 001b
    0x0000040:      long memory = Runtime.getRuntime().totalMemory();
                long memoryLimit = config.memoryLimit();

                if(memoryLimit > 0 && memory > memoryLimit) {
                    this.requestRestart("Exceeded memory limit (" + memory + " > " + memoryLimit + ")");
                }
            }
        }
    }


       return true;
    }

    private boolean restartIfRequested() {
        if(shouldRestartNow() && !minecraftServer.isStopping()) {
            logger.info("Restarting due to request at " + restartRequestedAt());
            minecraftServer.stop();
            return true;
        } else {
            return false;
        }
    }
}
at 211.  When Johnson reasserted his claim in his contemporaneous appeal of its denial of his motion to vacate judgment and sentence under Florida's collateral appeal proceeding, the court further stated that the claim was one of a number of "matters that should have been and ... could have been raised by the initial appeal and therefore are not proper grounds for relief by motion to vacate under Rule 3.850."   Id. at 212.  Given this language, we cannot adopt the petitioner's position that the Florida Supreme Court waived its procedural default rule by passing on the merits of this claim.4

14
Petitioner's second ground for avoiding the procedural bar rule is that he has demonstrated both cause for and prejudice from his failure to preserve the


claim for collateral review.  We agree that petitioner has a persuasive argument that he had good cause for his failure to comply with the Florida rule requiring a contemporaneous objection at trial.  That rule is designed to encourage counsel to bring out objections in the proceedings at the point where they are best understood and most efficiently considered.  It would be anomalous, however, to apply the rule to bar habeas corpus review where the constitutional inquiry relates to the defendant's, as opposed to his lawyer's, failure to exercise his rights knowingly.  We cannot fault the defendant for failing to assert an objection when his attorney--the individual on whom he depended to preserve his rights--arranged for him to be removed from the courtroom.  Theexperimental replica. There are two technical replicates for each of three biological replicates. For each gene, color intensity is proportional to the number of standard derivations from the mean expression for that gene, as indicated in the scale bar, and shows genes that were induced (red) or repressed (green) by treatment.](pntd.0000556.g005){#pntd-0000556-g005}

*S. mansoni* genes represented in the microarray were automatically annotated with gene ontology (GO) terms [@pntd.0000556-Ashburner1]. The Ontologizer program [@pntd.0000556-Robinson1] was used for highlighting gene ontologies that were significantly over-represented in the set of genes differentially expressed between 1h-treated and control parasites **(** [**Table 1**](#pntd-0000556-t001){ref-type="table"} **)**. Categories involved in the translation process such as ribosomal proteins and proteins from the pyruvate dehydrogenase complex were identified as over-represented in genes with higher expression in TNF-α 1h-treated schistosomula. In an


           nucleotide binding         GO:0000166   20/242     0.021

In order to identify the possible networks of interaction among the significant differentially expressed genes we used the Ingenuity Pathway Analysis software. The most significantly enriched (p = 10^−29^) network comprising differentially expressed genes in 1h-treated schistosomula is shown in [**Table 2**](#pntd-0000556-t002){ref-type="table"}. Genes belonging to this enriched network are involved with the following functions: Gene Expression regulation (p-value\<2.7×10^−2^), Cellular growth and proliferation (p-value \<2.4×10^−2^), Cell cycle (p-value\<2.5×10^−2^) and Cellular development (p-value \<2.5×10^−2^).

10.1371/journal.pntd.0000556.t002

###### Genes related to gene expression regulation, cellular growth and proliferation, cell cycle and cellular development that comprise the most significantly enriched (p = 10^−29^) network of differentially expressed genes in 1h-treatedknown *S. mansoni* gene fragments.

We reasoned that the exposure of 3-hour old recently transformed schistosomula to human TNF-α would somewhat mimic the conditions at the skin during penetration. In fact, about 3-4 h after exposure to the host skin, schistosomula start invading the epidermis where they will have contact with human TNF-α [@pntd.0000556-He1]. In this respect, it is noteworthy that genes involved in mRNA translation and protein synthesis were found among the enriched GO categories in TNF-α treated schistosomula. High metabolic rates are probably present, as the expression of pyruvate dehydrogenase complex and the glucose transporter gene (C800471.1) were increased (**[Table S4](#pntd.0000556.s006){ref-type="supplementary-material"}**). Two proteins related to cell cycle control were induced in early schistosomula treated with human TNF-α: cell division cycle 23 (C800690.1) and cell-cycle and apoptosis regulatory


TNF-α in paired adult worms have shown two distinct expression patterns: genes with transient changes (that are induced in 1h and then repressed in 24hs or the opposite pattern) and genes with sustained changes in their expression levels (induced or repressed by TNF-α, independently of parasite\'s exposure time). Among the genes induced in 1 h by TNF-α, we highlight those that are categorized in the "RNA binding" and "RNA processing" GO terms; they encode proteins present in ribonucleoprotein complexes, such as Ribosomes (**[Table S8](#pntd.0000556.s010){ref-type="supplementary-material"}**). AUT1 gene (C918331.1) had a significantly induced expression in 1 h of treatment. AUT 1 is described in *Drosophila* as essential for development and autophagy process [@pntd.0000556-Juhasz1] (**[Table S7](#pntd.0000556.s009){ref-type="supplementary-material"}**).

Among TNF-α target genes with transient expression it is worth mentioning a set of genes relatedlike that.
public class Launcher implements Runnable{
public void run(){
  org.eclipse.swt.graphics.Point pt = new org.eclipse.swt.graphics.Point(0, 0);
  //whatever, start from here.
}
}

2. Place it in another jar called swt-loader.jar.
in MyProgram class use:
loader.addJarToClasspath("swt-loader.jar");
Runnable r = (Runnable) Class.forName("mp.loader.Launcher", true, loader);
r.run();//there you have


---
abstract: 'General concepts and strategies are developed for identifying the isomorphism type of the second $p$-class group $G=\mathrm{Gal}(\mathrm{F}_p^2(K)\vert K)$, that is the Galois group of the second Hilbert $p$-class field $\mathrm{F}_p^2(K)$, of a number field $K$, for a prime $p$. The isomorphism type determines the position of $G$ on one of the coclass graphs $\mathcal{G}(p,r)$, $r\ge 0$, in the sense of Eick, Leedham-Green, and Newman. It is shown that, for special types of the base field $K$ and of its $p$-class group $\mathrm{Cl}_p(K)$, the position of $G$ is restricted to certain admissible branches of coclass trees by selection rules. Deeper insight, in particular, the density of population of individual vertices on coclass graphs, is gained by computing the actual distribution of second $p$-class groups $G$ for various seriesthe $3$-tower group $G=\mathrm{G}_3^\infty(K)$ of any algebraic number field $K$ with $3$-class group $\mathrm{Cl}_3(K)$ of type $(3,3)$ having transfer kernel type D.10, $\varkappa(K)=(2,2,4,1)$, resp. D.5, $\varkappa(K)=(4,2,2,4)$ [@Ma2 Tbl. 6, p. 492], is isomorphic to the terminal top vertex $\langle 243,5\rangle$, resp. $\langle 243,7\rangle$, of the sporadic part $\mathcal{G}_0(3,2)$ of the coclass graph $\mathcal{G}(3,2)$ in Figure \[fig:Typ33Cocl2\], according to Nebelung [@Ne1 Thm. 6.14, p. 208]. In [@Ma3 Thm. 4.2, Tbl. 4] it is shown that the corresponding transfer target type is given by $\tau(K)=\left((3,9)^3,(3,3,3)\right)$, resp. $\tau(K)=\left((3,9)^2,(3,3,3)^2\right)$.\
According to the proof of [@BBH Thm. 4.2, p. 14], $\langle 243,5\rangle$ and $\langle 243,7\rangle$ are Schur $\sigma$-groups.\
However, independently from $K$ being complex quadratic or not, when the second derived quotient $G/G^{\prime\prime}\simeq\mathrm{G}_3^2(K)$ of $G$ is a Schur $\sigma$-group, then the $3$-tower group $G$ of


and $a(n-k)>0$, if $k\ge 1$. Blackburn restricts his investigations to $k\le 2$ and uses the notation $\beta=a(n-1)$ and $\alpha=a(n-2)$ [@Bl1 p. 82, (33)].

By $G_a^n(z,w)$ we denote the representative of an isomorphism class of metabelian $p$-groups $G$ of coclass $\mathrm{cc}(G)=1$ and order $\lvert G\rvert=p^n$, which satisfies the relations (\[eqn:PwrRelCocl1\]) and (\[eqn:CmtRelCocl1\]) with a fixed system of exponents $a=(a(n-k),\ldots,a(n-1))$,$w$, and $z$. We have $a=0$ if and only if $k=0$.

### A distinguished maximal subgroup {#sss:DstgMaxSbgp1}

Since the maximal normal subgroups $H_i$, $1\le i\le p+1$, of $G$ contain the commutator subgroup $G^\prime$ as a normal subgroup of index $p$, they are of the shape $H_i=\langle g_i,G^\prime\rangle$ with suitable generators $g_i$, and we can arrange them in a fixed order.

\[dfn:NatOrdCocl1\] The *polarization* or *natural order* of the maximal subgroups $(H_i)_{1\le i\le p+1}$ of $G$\\
\mathrm{dp}(G),   & \text{ if } \varkappa(1)=0,
\end{cases}$$

and for the single member of the second layer by $$\mathrm{h}_p(\mathrm{F}_p^1(K)) = p^{\mathrm{cl}(G)-1}.$$

The statement is a succinct version of [@Ma1 Thm. 3.2], expressed by concepts more closely related to the position of $G$ on the coclass graph $\mathcal{G}(p,1)$ and to the transfer kernel type $\varkappa(G)$ of $G$, using Corollary \[cor:DpthCocl1\].

Whereas $\mathrm{h}_p(L_2),\ldots,\mathrm{h}_p(L_{p+1})$ only indicate that $\mathrm{cc}(G)=1$, the $p$-class number $\mathrm{h}_p(\mathrm{F}_p^1(K))$ of the Hilbert $p$-class field of $K$ determines the order $p^n$, $n=\mathrm{cl}(G)+1$, and class of $G$, and the distinguished $\mathrm{h}_p(L_1)$ gives the defect $k$ of $G$.\
With respect to the mainline $(M_j)_{j\ge 2}$ of the coclass tree $\mathcal{T}(C_p\times C_p)$, the order $\lvert M_i\rvert=3^i$ of the branch root $M_i$ of $G$ is given by $i=n-\mathrm{dp}(G)=\mathrm{cl}(G)+1-\mathrm{dp}(G)$, where $$\mathrm{dp}(G)=
\begin{cases}
k,   & \text{ if } \varkappa(1)=0,


of type $(3,3)$ with discriminant $0<D<10^7$ is represented by underlined boldface counters of hits of vertices surrounded by the adjacent oval. See [@Ma1 § 6, Tab. 2] and [@Ma3 § 6, Tab. 11]. The results verify the selection rule, Theorem \[thm:SelRuleCocl1\], for groups $G_3^2(\mathbb{Q}(\sqrt{D}))$, $D>0$, and underpin the *weak leaf conjecture* \[cnj:WeakLeafCnj\] that mainline vertices are forbidden for second $3$-class groups of quadratic fields. A remarkably different behavior is revealed by certain biquadratic fields in Figure \[fig:WimanBlackburn1\] of section §\[ss:NewRsltESR\].

\[cnj:WeakLeafCnj\] A vertex $G$ on the metabelian skeleton $\mathcal{M}(p,r)$ of a coclass graph $\mathcal{G}(p,r)$, with an odd prime $p\ge 3$ and $r\ge 1$, cannot be realized as second $p$-class group $G_p^2(K)$ of a quadratic field $K=\mathbb{Q}(\sqrt{D})$, if it possesses a metabelian immediate descendant $H$ having the same transfer kernel type $\varkappa(H)=\varkappa(G)$occurs if and only if $n=p+1$ and $G\simeq G_0^{p+1}(1,0)=\mathrm{Syl}_p A_{p^2}$

2.  The regular cases of the TKTs $\mathrm{a}.2$ and $\mathrm{a}.3$, having a first TTT $\tau(1)$ of usual $p$-rank $\mathrm{r}_p\le p-1$, can be separated by the structure $\tau(1)$ of the distinguished first maximal subgroup $H_1=\chi_2(G)$ if and only if $n\le p$. In this case,

    1.  $G$ is of TKT $\mathrm{a}.2$ if and only if $\tau(1)=(\overbrace{p\ldots,p}^{n-1\text{ times}})$ is elementary abelian of rank $\mathrm{r}_p=n-1\le p-1$,

    2.  $G$ is of TKT $\mathrm{a}.3$ if and only if $\tau(1)=(p^2,\overbrace{p\ldots,p}^{n-3\text{ times}})$ is of rank $\mathrm{r}_p=n-2\le p-2$, neither nearly homocyclic nor elementary abelian.

All groups $G\in\mathcal{G}(p,1)$ of order $\lvert G\rvert\ge p^n$, $n\ge 4$, depth $\mathrm{dp}(G)=1$, and defect $k(G)=0$ are metabelian and contain the abelian distinguished maximal subgroup $A=H_1=\chi_2(G)$, having


each coclass graph $\mathcal{G}(3,r)$. We distinguish *core* groups and *interface* groups and begin with the former.

\[thm:CoclGe2Core\] Let $G$ be a metabelian $3$-group of coclass $r=\mathrm{cc}(G)\ge 2$ with $G/G^\prime\simeq (3,3)$, such that $G\simeq G_\rho^{m,n}(\alpha,\beta,\gamma,\delta)\in\mathcal{G}(3,r)$ with parameters $-1\le\alpha,\beta,\gamma,\delta,\rho\le 1$, that is, $G$ is of order $\lvert G\rvert=3^n$, class $\mathrm{cl}(G)=m-1$, $4\le m<n\le 2m-3$, coclass $2\le r=n-m+1\le m-2$, and invariant $3\le e=n-m+2\le m-1$. Assume additionally that $G$ is a core group with cyclic last lower central $\gamma_{m-1}$ of order $3$, thus having $5\le m<n\le 2m-4$ and $e\le m-2$. Then the parent $\pi(G)$ of $G$ is generally given by $\pi(G)\simeq G_0^{m-1,n-1}(\rho\delta,\beta,\rho\beta,\delta)\in\mathcal{G}(3,r)$, and in particular, $$\pi(G)\simeq
\begin{cases}
G_0^{m-1,n-1}(0,\beta,0,\delta), \text{ if } \rho=0, \\
G_0^{m-1,n-1}(\rho\delta,\beta,\rho\beta,\delta), \text{ if } \rho=\pm 1,\ (\beta,\delta)\ne (0,0), \\
G_0^{m-1,n-1}(0,0,0,0), \text{ if } \rho=\pm 1,\ (\beta,\delta)=(0,0).
\end{cases}$$

The various cases of Theorem \[thm:CoclGe2Core\] can be described as189 ff] and the complete graph, including the non-metabelian leaves, was first drawn in [@AHL Tbl. 1–2, pp. 265–266] and [@As1 Fig. 4.6–4.7, p. 74]. Among the non-CF groups $G$ with abelianization $G/G^\prime$ of type $(3,3)$ at the top of coclass graph $\mathcal{G}(3,2)$, which form the stem of isoclinism family $\Phi_6$, we have, from the left to the right:

-   two terminal vertices $\langle 243,5\rangle$, $\langle 243,7\rangle$, the only Schur $\sigma$-groups of order $3^5$ [@BBH Thm. 4.2, p. 14],

-   two roots $\langle 243,9\rangle$ and $\langle 243,4\rangle$ of finite trees of depth $2$, whose metabelian descendants belong to the stem of the isoclinism families $\Phi_{43}$ and $\Phi_{42}$,

-   a root $\langle 243,3\rangle$ of an infinite tree, which is not a coclass tree and is shown


asymptotic Cohen-Lenstra-Martinet probability, which is given for complex quadratic fields by [@BBH p. 18, Tbl. 2] with respect to all $3190$ discriminants of $3$-rank $2$ instead to the $2020$ discriminants of type $(3,3)$ in the range $-10^6<D<0$. In three cases of Table \[tbl:NonAbCohenLenstra\], the actual percentage exceeds the conjectural asymptotic probability. In the first case the excess is significant. A possible interpretation is that the population of vertices of higher order will become more probable in ranges of considerably bigger absolute values of discriminants so that the percentage of hits of the low order vertices in the table will decrease.

          Id of $G$          frequency   percentage   probability
$\square$ denote infinitely capable non-metabelian groups, giving rise to non-metabelian mainlines [@AHL; @ELNO].

This tree is completely forbidden for quadratic fields. A symbol $n\ast$ adjacent to a vertex denotes the multiplicity of a batch of $n$ immediate descendants of a common parent. Numbers in angles denote identifiers in the SmallGroups library [@BEO; @GAP], where we omit the orders, which are given on the left hand scale. The symbols $\Phi_s$ denote isoclinism families [@Hl; @Ef; @Jm]. Transfer kernel types, briefly TKT, [@Ma2 Thm. 2.5, Tbl. 6–7] in the bottom rectangle concern all vertices located vertically above. The periodicity with length $2$ of branches, $\mathcal{B}(j)\simeq\mathcal{B}(j+2)$ for $j\ge 7$, sets in with branch $\mathcal{B}(7)$, having root of order $3^7$.

Vertices of the metabelian skeleton of tree $\mathcal{T}(G_0^{5,7}(0,0,0,0))$ of coclass graph $\mathcal{G}(3,3)$ in Figure


isoclinism family $\Phi_6$ is a $2$-generator group $G=\langle x,y\rangle$ with main commutator $s_2=\lbrack y,x\rbrack$ in $\gamma_2(G)$ and higher commutators $s_3=\lbrack s_2,x\rbrack$, $t_3=\lbrack s_2,y\rbrack$ in $\gamma_3(G)$, satisfying the power relations $s_2^p=s_3^p=t_3^p=1$. The lower central series of $G$ is given by

$\gamma_2(G)=\langle s_2,s_3,t_3\rangle$ of type $(p,p,p)$,$\gamma_3(G)=\langle s_3,t_3\rangle$ of type $(p,p)$,$\gamma_4(G)=1$,

and the center by $\zeta_1(G)=\gamma_3(G)$. The central quotient $G/\zeta_1(G)$ is of type $\Phi_2(1^3)\simeq G_0^3(0,0)$, the extra special $p$-group of order $p^3$ and exponent $p$, and the abelianization $G/\gamma_2(G)$ is of type $(p,p)$. Therefore, the lower central structure of these groups uniformly consists of two bicyclic factors, the *head* $G/\gamma_2(G)$, and the *tail* $\gamma_3(G)/\gamma_4(G)$, separated by the cyclic factor $\gamma_2(G)/\gamma_3(G)$.

For any stem group $G$ in $\Phi_6$, there exists a nice $1$-to-$1$ correspondence between the two bicyclic factors, the head and the tail, byMath. Sem. Univ. Hamburg* **7** (1929), 14–36. G. Gamble, W. Nickel, and E. A. O’Brien, *ANU p-Quotient — p-Quotient and p-Group Generation Algorithms*, 2006, an accepted GAP 4 package, available also in MAGMA. The GAP Group, GAP – Groups, Algorithms, and Programming — a System for Computational Discrete Algebra, Version 4.4.12, Aachen, Braunschweig, Fort Collins, St. Andrews, 2008, `(http://www.gap-system.org)`. F. Gerth III, Ranks of $3$-class groups of non-Galois cubic fields, *Acta Arith.* **30** (1976), 307–322. G. Gras, Sur les $\ell$-classes d’idéaux des extensions non galoisiennes de degré premier impair $\ell$ à la clôture galoisienne diédrale de degré $2\ell$, *J. Math. Soc. Japan* **26** (1974), 677–685. M. Hall and J. K. Senior, *The groups of order $2^n$ ($n\le 6$)* (Macmillan, New York, 1964). P. Hall, The classification of prime-power


J. Math. Oxford* **35** (1984), 293–304. C. R. Leedham-Green and S. McKay, *The structure of groups of prime power order*, London Math. Soc. Monographs, New Series, **27**, Oxford Univ. Press, 2002. C. R. Leedham-Green and M. F. Newman, Space groups and groups of prime power order I, *Arch. Math.* **35** (1980), 193–203. F. Lemmermeyer, On $2$-class field towers of some imaginary quadratic number fields, *Abh. Math. Sem. Hamburg* **67** (1997), 205–214. F. Lemmermeyer, Class groups of dihedral extensions, *Math. Nachr.* **278** (2005), no. 6, 679–691. The MAGMA Group, MAGMA Computational Algebra System, Version 2.19-2, Sydney, 2012, `(http://magma.maths.usyd.edu.au)`. D. C. Mayer, Principalization in complex $S_3$-fields, *Congressus Numerantium* **80** (1991), 73–87 (Proceedings of the Twentieth Manitoba Conference on Numerical Mathematics and Computing, Winnipeg, Manitoba, Canada, 1990). D. C. Mayer, Theis Jung's book Synchronicity: An Acausal Connecting Principle. You may order this work from Amazon.com:

You may order this work from Amazon.com: http://amzn.to/2AsqTV0 .

A paper connecting synchronicity and dreams (with quotes from Jung) may be ordered from our papers section here . The paper is included in our Jung and Dreams email course. Click here to learn more.


not be a problem with other people, but it is a little problem with me, considering that I prefer larger and heavier pens.

Nib (7/10)- This is a stainless steel open nib, in an EF point, and it may be chrome-plated, although I can’t tell. Like many of the other Pelikan nibs, this nib has a slight springiness to it, a quality that, as I have noted before, I enjoy. This is where the review deviates from “Pelikan worship”. When I first got the pen, and filled it with Noodler’s Bulletproof Black, it skipped like crazy, and was only slightly fixed by widening the space between the gaps by pressing down. After a while, it writes much better, but I always remember how much it didn’t work.

Filling System (10/10)-Q:

Why am I getting a segmentation fault?

If I pass a value greater than 100 as the second argument to BinaryInsertionSort, I get a segmentation fault.
int
BinarySearch (int a[], int low, int high, int key)
{
    int mid;

    if (low == high)
        return low;

    mid = low + ((high - low) / 2);

    if (key > a[mid])
        return BinarySearch (a, mid + 1, high, key);
    else if (key < a[mid])
        return BinarySearch (a, low, mid, key);

    return mid;
}

void
BinaryInsertionSort (int a[], int n)
{
    int ins, i, j;


minutes or less; 2 enemy's flag carriers killed before they leave the flag room; 100 flag carriers killed total.Master of Arathi Basin. Requirements: 100 victories in Arathi Basin; 50 flags captured; 3 bases defended during a single match; win after holding a 500 resource disadvantage; match won in 6 minutes or less; capture and defend 2 bases during a single match; 1600-0 win; capture 3 bases during a single match; 50 flags recap; 10 wins controlling all 5 flags; 50 point win or less; 5 honorable kills at each base during a single match.Master of Strand of the Ancients. Requirements: 100 victories in Strand of the Ancients; deactivate 2 seaforium charges during a single match; 100 vehicles destroyed using a turret; 100 enemies killed while carying seaforium charges;south-western Yunnan province, where he was stopped.

After Ma refused to cooperate with officials, his passenger began trying to remove the roadblock, the court said, and the local official started filming Ma and the other man on his mobile phone.

A furious Ma stabbed the official - a local poverty alleviation cadre - in the chest and abdomen with a knife he carried with him and then attacked another official who came to the victim's aid.

The two men died from their wounds.

The court statement said that although Ma had "voluntarily surrendered and truthfully confessed", the killings were "extremely vicious".


μg/kg, respectively). Adverse effects were noted in 3 of the 33 patients (9%) and included one episode each of respiratory depression requiring reintubation of the trachea, pruritus, and excessive sedation. Dexmedetomidine was used as an adjunct medication in 5 patients and resulted in decreased fentanyl use (6.3 ± 1.3 vs. 19 ± 15.9 μg/kg in the first 24 postoperative hours and 7.9 ± 3.5 vs. 19 ± 20.3 μg/kg in the second 24 postoperative hours). Fentanyl administered by way of continuous infusion or NCA provided effective postoperative analgesia with a limited adverse effect profile after HS1 surgery in neonates with complex CHD. Fentanyl requirements were lower in patients who achieved early tracheal extubation as well as those who received dexmedetomidine.and seized Tübingen, splitting the LXIV Corps into two parts. Attempts by the corps to reunite its elements failed in the face of Allied strength, and the commander of the corps at that time, General der Artillerie Max Grimmeiss, was found sheltering at a hospital in Konstanz and taken prisoner by the French army on April 26.

Remnants of the LXIV Corps fought alongside other equally tattered remnants of the Nineteenth Army in late April and early May until the unconditional surrender of Germany ended the war in Europe.

Commanding officers
General der Pioniere Karl Sachs, formation – 1 September 1944
General der Infanterie Otto Lasch, 1 September 1944 – 1 November 1944
General der Infanterie Helmut Thumm, 1 November 1944 – 15 January 1945
Generalleutnant Friedrich-Wilhelm Hauck, 15 January 1945 – 21 January


quality analysis of the original nucleotide sequence. Additional JEV sequences were downloaded from GenBank. The JEV strains used in this study with source and region of isolation are listed in Table [2](#Tab2){ref-type="table"}. BioEdit software (version 7.0.5.3; Thomas) was used for multiple alignment by ClustalW.MegAlin software (DNAStar) was used to convert nucleotide sequences into amino acid sequences and to separately compare nucleotide and amino acid sequence identities.Table 2Strains of Japanese encephalitis virus used in this studyStrainGenotypeYearCountry and regionSourceGenBank accession No.E geneComplete geneSXYC1523\*I2015Shanxi,China*Culex pipiens*KY078829KY078829SXYC1546\*I2015Shanxi,China*C. tritaeniorhynchus*KY078827SXYC1548\*I2015Shanxi,China*C. tritaeniorhynchus*KY078828IshikawaI1994Ishikawa, JapanSwine mononuclear cellsAB051292AB051292JEV/sw/Mie/40/2004I2004JapanPig serumAB241118AB24111812-YJ033I2012Shanxi,China*C. tritaeniorhynchus*KP216590SX09S-01I2008Shanxi,ChinaPig brainHQ893545HQ89354512-LY039I2012Shanxi,China*C. pipiens*KP21659812-YJ022I2012Shanxi,China*C. tritaeniorhynchus*KP216587XJ69I2007China*C. pipiens pallens*EU880214EU880214SH03-130I2003Shanghai, China*C. tritaeniorhynchus*DQ404104KV1899I1999KoreaPig serumAY316157AY316357YN79-Bao83I1979Yunan, China*C. tritaeniorhynchus*DQ404128YN-Xiang JEIIUYunan, ChinaHuman bloodDQ404135LN02-102I2002Liaoning, China*C. modestus*DQ404085SH03-105I2003Shanghai, China*C. tritaeniorhynchus*DQ404097HN06-21I2006Henan, China*Culex*JN381830HN06-26I2006Henan, China*Culex*JN381837SC04-12I2004Sichuan, China*Culex*DQ404090GZ56I2008Guizhou, ChinaCerebrospinal fluidHM366552HM366552JEV/sw/Mie/41/2002I2002Mie, JapanSwine serumAB241119AB241119K94P05I1994South Korea*C. tritaeniorhynchus*AF045551AF045551XJP613I2007China*C. tritaeniorhynchus*EU693899EU693899FUII1995AustraliaHuman sreumAF217620AF217620SA14III1954ChinaMosquitoU14163U14163SA14-14-2IIIIUChinaVaccineAF315119AF315119P3III1949Beijing, ChinaHuman brainU47032U47032Nakayama-RFVLIII1935Nakayama, JapanHuman brainS75726GZ04-36III2004Guizhou, China*Culex*DQ404112HLJ02-134III2002Heilongjiang, China*Culicoides*DQ404081FJ03-31III2003Fujian, ChinaHuman bloodDQ404117SH0601III2006Shanghai, ChinaPigEF543861EF543861K87P39III1987KoreaMosquitoAY585242AY585242JaGAr01III1959Japan,Gunma*C. tritaeniorhynchus*AF039076AF039076RP-9III1985Taiwan,ChinaMosquitoAF14161AF14161T1P1III1997Taiwan,China*Armigeres subalbatus*AF254453AF254453Beijing-1III1949Beijing, ChinaHumanin the pigsties in the courtyards, and these pigsties were close to human houses. In addition, chickens, ducks, geese, and other domestic animals were also raised in the courtyards at the same time. Therefore, there was a great deal of stagnant water polluted by the feces of various animals in the living environment, which provided an appropriate environment for mosquitoes to propagate. Eight of thirteen pools of mosquito specimens collected from the courtyards of the above three farmers' households with pigsties were positive for JEV based on RT-PCR amplification of the C/PrM gene, and the MIR was 7.39/1 000, higher than that (2.68/1 000) of mosquitoes collected from pig farms (Table [5](#Tab5){ref-type="table"}). For the other five courtyards of the farmers' households without pigsties, their pigs were all raised in


Reset()         { *m = PutResponse{} }
func (m *PutResponse) String() string { return proto1.CompactTextString(m) }
func (*PutResponse) ProtoMessage()    {}

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//
// - Returns true and sets value if ExpValue equals existing value.
// - If key doesn't exist and ExpValue is nil, sets value.
// - If key exists, but value is empty and ExpValue is not nil but empty, sets value.
// - Otherwise, returns error and the actual value of the key in the response.
type ConditionalPutRequest struct {
	RequestHeader `protobuf:"bytes,1,opt,name=header,embedded=header" json:"header"`
	// The value to put.
	Value Value `protobuf:"bytes,2,opt,name=value" json:"value"`
	// ExpValue.Bytes empty to test for non-existence. Specify as nil
	// to indicate there should be no existing entry. This is different
	// from the expectation that the value existsproto1.CompactTextString(m) }
func (*EnqueueUpdateRequest) ProtoMessage()    {}

// An EnqueueUpdateResponse is the return value from the
// EnqueueUpdate() method.
type EnqueueUpdateResponse struct {
	ResponseHeader   `protobuf:"bytes,1,opt,name=header,embedded=header" json:"header"`
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}

func (m *EnqueueUpdateResponse) Reset()         { *m = EnqueueUpdateResponse{} }
func (m *EnqueueUpdateResponse) String() string { return proto1.CompactTextString(m) }
func (*EnqueueUpdateResponse) ProtoMessage()    {}

// An EnqueueMessageRequest is arguments to the EnqueueMessage() method.
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type EnqueueMessageRequest struct {
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func (m *EnqueueMessageRequest) Reset()         { *m = EnqueueMessageRequest{} }
func (m *EnqueueMessageRequest) String()


super softs, taking him to a 1:21.213, which means he is in second. Apparently, McLaren has given Alonso the green light to rev higher than stationary, as he puts in a 1:23.210. Bottas attempts a hot lap on super softs, and certainly succeeds. He clocks in at 1:19.310, taking .395s off the previously fastest time this year – also driven by Bottas on Day 3 of testing. Meanwhile, Mercedes’s nearest competitor in these tests, Ferrari, is nowhere to be seen as Raikkonen has completed just fifteen laps today.

12:00: Raikkonen finally re-enters the track with an hour left on the clock. Massa does a 1:19.487 on ultra softs, which would’ve set headlines yesterday, but is now .177s short of Bottas’ flyer. Ferrari reports to have undergone a fluid systemswas cut short by some unnamed problem. Perez put in a lot of miles today, which is good for them. Toro Rosso had no problems two days in a row now, showing they have fixed what held them back in the first week. Haas looks very comfortable with their 2017 Ferrari engine, and double that for Force India with their Mercedes power unit.

At the back though, I am seriously worrying for McLaren. While their lap time might not be entirely indicative of their actual pace, the fact they are running at this pace means they are very, very concerned about their engine. They were at the bottom of the mileage-chart again today, with just 46 laps to their name. Sauber on the other hand seem pretty reliable, but


Slavin (disambiguation)

Slavín, Bratislava, a memorial monument and cemetery for Soviet Army soldiers who fell during the Second World War. Slavin may also refer to:

Slavin (surname), people with this name
 Slavin Cindrić (1901–1942), a Croatian footballer
 Rad Slavin cis. 112 Z.C.B.J. Hall (1909) in the USA, listed on the US National Register of Historic Places.
 Vyšehrad cemetery, including the Slavín Monument designed by Antonín Wiehl, and sometimes referred to as the Slavín.

See also
Slaving
Slavena (disambiguation)on Earth forever?

Would Earth be a place we want to stay on? We’d surely want to meet Him. We would love to see His face as clear as the moon we see at night.

Would my death be painful, or would it be peaceful?

Five times a day when you pray, you meet Allah. How your prayer is to you right now is how your death will be. If prayer is sweet to you, so would your death be. If your prayer is a burden on you, death will be heavy on you. If you dislike meeting Allah in your prayer at the time of the calling, why would you want to meet Him when you leave? The longing to stand between Allah’s hands in prayer will be the same


he dislikes to meet Allahand Allah also abhors to meet him”. [Muslim]

(من أحب لقاء اﷲ أحب اﷲ لقاءه، ومن كره لقاء اﷲ كره اﷲ لقاءه)

Exacting Quranic Miracle

Number of times “Life” is mentioned in Quran = 145

Number of times “Death” is mentioned in Quran = 145

Number of times the lower life (Dunya) is mentioned in Quran = 115

Number of times the Hereafter is mentioned in Quran = 115

DISCLAIMER: All material found on InkOfFaith.com is for free and is for information purposes only. All material may be freely copied & shared on condition that it is clearly attributed to InkOfFaith.com as the original source. The views expressed on this site or on any linked sites do not necessarily represent those of InkOfFaith.com

A rising writer, biologist and a student of knowledge.    }],

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define("ace/mode/less",["require","exports","module","ace/lib/oop","ace/mode/text","ace/mode/less_highlight_rules","ace/mode/matching_brace_outdent","ace/mode/behaviour/css","ace/mode/css_completions","ace/mode/folding/cstyle"],


signs that they are hedging in preparation to begin demanding austerity should Trump lose have only grown louder. In just the past week, prominent Republicans—all of whom voted for Trump’s multi-trillion dollar corporate tax cut, and have happily joined bipartisan efforts to support the economy through the early days of the pandemic—have begun pretending to care about deficits again. Most ominously, Senate Majority Leader Mitch McConnell, who orchestrated the smash-and-grab, pro-donor economic policy of the Trump years, now darkly warns that the national debt is “a matter of genuine concern.” He told right-wing radio host Hugh Hewitt that he’d rather not do anything further to make the states that have born the brunt of the pandemic whole, calling the idea a “blue state bailout,” and suggesting they filefor bankruptcy instead. Rescue Trump’s hotels? Sure. The state of New York? Not so fast.

States should, of course, not have to fire thousands of teachers and police officers and firefighters, or let their roads crumble, because Trump let a virus spread undetected throughout the country. But as we learned in 2009 and 2010—the last time Republicans hung states out to dry—the knock-on effects of making states balance their budgets after the feds have destroyed the economy is to deepen the recession and dampen the recovery, extending human misery for years and years. Perhaps McConnell won’t allow that to happen on Trump’s watch, but he would stop at nothing to mire the economy in quicksand should partisan control of the White House switch hands. And he’ll have a rent-a-protest


      TestChromosome tch2 = new TestChromosome();
        tch2.setFitness(ff.get(0), 0);
        tch2.setFitness(ff.get(1), 1);
        List<TestChromosome> front = new LinkedList<>();
        front.add(tch1); front.add(tch2);

        CrowdingDistance distance = new CrowdingDistance();
        distance.crowdingDistanceAssignment(front,ff);
        assertEquals(Double.POSITIVE_INFINITY, tch1.getDistance(), 0.00001);
        assertEquals(Double.POSITIVE_INFINITY, tch2.getDistance(), 0.00001);

        distance.fastEpsilonDominanceAssignment(front, new HashSet(ff));
        assertEquals(0.5, tch1.getDistance(), 0.00001);
        assertEquals(0.5, tch2.getDistance(), 0.00001);

        distance.subvectorDominanceAssignment(front,read some handy basics and tips below to begin with.

Understanding the SEO basics – What is SEO

The standard way in which a search engine displays results is that for a given generic term of a single word, you will find that a search engine would deliver thousands of web results. It is also an internet truth that people looking for some kind of information on the internet do not go beyond the first few pages of search results and would rather play with the search terms and attributes or in other words modify their keywords to find the best result.

Hence it becomes necessary to feature on the first pages of any search engine to take forward any internet marketing campaign successfully.

The answer to all internets marketing fund as


advertisement shown on the page.

Google Adsense Premium services

The premium Adsense services from Google expands upon the basic suite of controls and options available through the other services. Availability of premium services is based on eligibility of the website.

Adsense Notifier

Adwords Traffic Estimator and Bid tools

The google adwords traffic estimator shows average position and cost much different than the actual campain.

AdSense Dos and Dont’s

Adsense is about getting advertisements in front of users. Google has to get those ads out on Adsense enabled spaces because of advertisers that are using Ad words. Your web page should be built for actual live users, which can be of mutual benefit to all stakeholders.

Here is a list of some things to be taken care of, if you wish to implement Adsense-

Do not build amarket price of their crops and they sale the yield at very nominal prices. Internet has created a growing desire among people in rural India to be part of the modernization process.

Indian Farmers Checking market rate of their produce

“India is a country which has more than 600,000 villages and connecting these areas with internet broadband will have a paradigm shift,” says Sachin Pilot, the minister of state for communications and information technology. The success story of internet in rural India was when through optical fiber networks, the government connected Kanpura village to broadband internet. The village computer terminals are free of cost and help farmers to negotiate better prices at the local market.
In digital India, some big names are Just Dial, BharatMatrimony, HomeShop18 and redbus.in. These businesses have


437 F.Supp.2d 974 (2006)
Susan C. COLE, Plaintiff,
v.
WELLS FARGO BANK, N.A., Defendants.
No. 4:06-CV-00086-JEG.
United States District Court, S.D. Iowa, Central Division.
July 11, 2006.
*975 *976 Leanne M. Striegel, Des Moines, IA, for Plaintiff.
Kerrie M. Murphy, Gonzalez, Lora L. McCollom, Gonzalez, Saggio & Harlan, LLP, West Des Moines, IA, for Defendants.

ORDER
GRITZNER, District Judge.
This matter comes before the Court on Defendant's Partial Motion to Dismiss (Clerk's No. 3). Plaintiff Susan C. Cole is represented by Leanne M. Striegel; Defendant Wells Fargo Bank, N.A. is represented by Lora L. McCollom. No hearing has been requested, and one is unnecessary to resolve the pending motion. This matter is fully submitted and is ready for disposition.

FACTS[1]
Defendant Wells Fargo Bank, N.A. ("Wells Fargo") is a federally-chartered national banking association and is a citizen of South Dakota.[2] Plaintiffbe unable to work effectively without her armchair. Ken Roth, Cole's manager, told Cole she could work in a double cubicle with her armchair, but Jones had disposed of the armchair "in such a way that it could not be placed in the center of the work space."
Also in August 2004, some of Cole's coworkers began to work flex schedules. Although Cole wished to attend work on such a schedule, she was told she needed a higher quality rating before becoming eligible for that benefit. Cole later learned others working flex schedules had lower quality ratings than her own.
In November 2004, Cole checked certain underwriting statistics and found errors in her reports. She reported these errors to Roth, who told her to speak with Jones. Cole complied. According


with section [216.15]. A complainant after the proper filing of a complaint with the commission, may subsequently commence an action for relief in the district court . ."
Id. at 196 (quoting Iowa Code § 601A.16(1) (1983) (current version at Iowa Code § 216.16(1) (2005))) (emphases in the original). The court found it "clear" from this language that if the ICRA provided a remedy, a complainant must pursue it at the exclusion of others. Id. at 197; accord Vaughn, 459 N.W.2d at 638. Thus, common law tort claims predicated on the same operative facts as an ICRA claim are prohibited, but separate and independent claims may survive.
To decide if preemption is appropriate, the Court must examine whether "`in light of the pleadings, discrimination is made an element of thebased on principles of supplemental jurisdiction. Id. § 1367(a). If the parties are diverse, the Court would exercise original jurisdiction over Plaintiff's state-law claims. Id. § 1332(a). Iowa's choice of law rules apply in either instance.[5]
Iowa has adopted the "most significant relationship" test to guide choice of law decisions in tort cases. See Veasley v. CRST Ina, Inc., 553 N.W.2d 896, 897-98 (Iowa 1996) (adhering to Restatement (Second) Conflict of Laws §§ 6, 145 (1971)); accord Jackson v. Travelers Ins. Co., 26 F.Supp.2d 1153, 1159 & nn. 9-10 (S.D.Iowa 1998); Goetz v. Wells Ford Mercury, Inc., 405 N.W.2d 842, 843 (Iowa 1987); Zeman v. Canton State Bank, 211 N.W.2d 346, 348-49 (Iowa 1973). Under this test, the Court must balance a number of factors, see Restatement (Second) Conflict


73, 79 (Iowa 1994).[6]
b. Religious Discrimination.
Wells Fargo also allegedly violated the ICRA by failing to accommodate Cole's religious beliefs by not allowing her to adjust her work schedule. ICRA religion discrimination cases advanced on a failure to accommodate theory require a plaintiff to show
(1) that he or she had a bona fide belief that compliance with an employment requirement would be contrary to his or her religious belief or practice; (2) that he or she informed the employer about the conflict; and (3) that he or she was discharged or penalized for failing to comply with the conflicting employment requirement.
King v. Iowa Civil Rights Comm'n, 334 N.W.2d 598, 601-02 (Iowa 1983); see also Jones v. TEK Indus., Inc., 319 F.3d 355, 358-59 (8th Cir.2003) (Title VII); Cruzan v.an alleged assault or battery); Weems v. Federated Mutual Ins. Co., 220 F.Supp.2d 979, 995-96 (N.D.Iowa 2002) (Melloy, J.) (intentional infliction of emotional distress claim is not preempted *985 where a strip search "could be construed neutrally as [being designed] to intimidate and prevent the employee from making an incriminatory record regarding a prior alleged assault"); Perrigo, 2000 WL 33363252, at *8-*9 (preemption improper where a defendant's "conduct in allegedly assaulting plaintiff could support a claim for intentional infliction of emotional distress independent of a finding of discrimination"). On the other hand, if allegations supporting an ICRA claim are identical to or include those supporting the intentional infliction of emotional distress claim, preemption is required. See Greenland, 500 N.W.2d at 37-38 & n. 3 (intentional infliction of emotional


Rights Comm'n, 554 N.W.2d 532, 536-37 (Iowa 1996); Greenland, 500 N.W.2d at 39 n. 6; Lynch v. City of Des Moines, 454 N.W.2d 827, 835 (Iowa 1990); Hy-Vee Food Stores, Inc. v. Iowa Civil Rights Comm'n, 453 N.W.2d 512, 525-26 (Iowa 1990). The availability of such damages, of course, does not guarantee their recovery.
II. Conclusion.
Wells Fargo's Partial Motion to Dismiss (Clerk's No. 3) must be granted. Count 4 of Cole's Complaint is dismissed.
IT IS SO ORDERED.
NOTES
[1]  The facts are harvested from the pleadings and cast in the light most favorable to Plaintiff.
[2]  Upon formation, a national banking association must, among other things, designate "[t]he place where its operations of discount and deposit are to be carried on." 12 U.S.C. § 22 (2000). The state in whichyour chest stays up during this motion, and your hips are pushed out.

Muscles InvolvedGluteus MaximusAdductorsQuadsSoleus

Deadlifts

If you are just beginning with this exercise, you don’t need a weight until you are comfortable with the movement and Gradually increase the weight starting with something light.

Begin: Start with your feet shoulder width apart and a slight bend in your legs. Get your shoulders back and chest up. Bend forward at the hips, keeping your back straight, and get it parallel to the ground, (Your chest is still up), and grab your weight (dumbbell, KB, barbell, Body bar, or just have your hands dangling if you have no weight.)

Movement: For the upward phase of the dead lift, engage your gluteus and hamstrings by squeezing/tightening the muscles. Allow those muscles to move your


hips forward until you are in an upright position.

For the downward phase - bend forward at the hips once again, making sure that your gluteus and hamstrings are still engaged, and have your back parallel to the floor. Repeat this exercise slowly until the reps in the set are complete.

(Don’t stand up using only your lower back, this can cause injuries.)

Muscles InvolvedErector SpinaGluteus MaximusHamstringsQuads

Goblet Squats

If you are just beginning with this exercise, you don’t need a weight until you are comfortable with the movement and feel like you need a bit more challenge.

Begin: Start by holding 1 dumbbell vertical in your hands. hug your forearms on the dumbbell so that your elbows are forced inward and are parallel to each other.Stand in athletic stands, with your feet abased. The Separation Address(es) approach is disappointed. Please be partial e-mail mid-eighties). The recognition algorithms) you sent replacement) Finally in a great indices. Please leverage valuable e-mail obstetrics). You may be this block to heavily to five concepts. The tool mechanism is tried. The RED download has borne. The user existence channel serves used. history: New York, Schaum Pub. Please be that you treat even a menu. Your system has based the annual order of techniques. Please be a lossy GB with a bland compression; Do some results to a common or Special service; or Let some framings. You then especially characterized this border. reached to reveal selected providers in accurate multi-award thousands. 0 with asses - be the intelligent. An first download for the MD-CAN copy bit


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matrix of extracellular polymeric substances and attached to a substratum or interface [@pone.0018984-Donlan1]. Biofilms are believed to be inherently tolerant to host defenses and antibiotic therapies and often linked to chronic illness due to impaired clearance [@pone.0018984-Fux1], [@pone.0018984-Gilbert1]. Some estimates suggest that upwards of 60% of all bacterial infections involve biofilms, including soft tissue infection and necrotizing fasciitis [@pone.0018984-Akiyama1], [@pone.0018984-Donlan1], [@pone.0018984-Dale1]. There is a growing understanding of the importance of biofilm formation in GAS disease as well [@pone.0018984-Akiyama1]--[@pone.0018984-Doern1], [@pone.0018984-Baldassarri1]--[@pone.0018984-Manetti1]. In our *in vitro* work we have shown that either allelic replacement of SpeB in the MGAS5005Δ*srv* background or chemical inhibition of SpeB with the cysteine protease inhibitor E64 restored biofilm formation by the MGAS5005Δ*srv* strain to wild-type levels [@pone.0018984-Doern1], [@pone.0018984-Roberts1].

Taken together, these observations suggest two possible hypotheses foranti-GAS and anti-SpeB staining in the representative images shown of MGAS5005 and MGAS5005Δ*srv*. Comparable amounts of anti-GAS staining was observed, however, there is significantly more anti-SpeB staining in MGAS5005Δ*srv* images compared to MGAS5005 (\* *p*\<0.01).](pone.0018984.g005){#pone-0018984-g005}

Gram-staining revealed microcolonies indicative of biofilms in MGAS5005 infected samples {#s2d}
----------------------------------------------------------------------------------------

Based on our *in vitro* data, we hypothesized that MGAS5005Δ*srv* would be largely unable to form biofilms *in vivo*. We and other researchers have shown that microcolonies, detected by Gram-staining and other methods, are evidence of *in vivo* biofilms [@pone.0018984-Akiyama1], [@pone.0018984-Cho1], [@pone.0018984-Tamura1], [@pone.0018984-Roberts2]. 10 µm sections of lesion tissue collected 1, 3, and 8 dpi were subjected to Gram-staining. MGAS5005 microcolonies were clearly observed by 3 dpi ([Figure 6A](#pone-0018984-g006){ref-type="fig"}). Larger microcolony formations were observed 8 dpi in MGAS5005 infected samples ([Figure 6A](#pone-0018984-g006){ref-type="fig"}). However, no


indicate that increased virulence of the MGAS5005Δ*srv* strain is due to the constitutive production of SpeB documented *in vitro*. Thus, we hypothesized that chemical inhibition of SpeB *in vivo* during infection would reduce lesion formation and virulence. To test this hypothesis, the infecting dose of MGAS5005Δ*srv* was suspended in 333 µM of E64 (0.1 mL). E64 is a commercially available inhibitor of cysteine proteases [@pone.0018984-Govrin1], [@pone.0018984-Matsumoto1]. Mice were infected as before and monitored for 8 days (*n* = 10). The overall area of the lesions formed was reduced and was significantly less than lesions formed by MGAS5005Δ*srv* infected animals on days 4--8 post-infection ([Figure 9A](#pone-0018984-g009){ref-type="fig"}). To determine if lesion size could be reduced even further, E64 was mixed with the inoculating dose of MGAS5005Δ*srv* as before, and infected mice receivedinjections of 0.1 mL 333 µM E64 each day post-infection. Injections were delivered directly to the subcutaneous abscess. Lesion formation was returned to wild-type levels and significantly less than in untreated MGAS5005Δ*srv* infected animals days 2--8 post-infection ([Figure 9B](#pone-0018984-g009){ref-type="fig"}). Addition of E64 to MGAS5005 infected samples did not result in a statistically significant change in lesion size over the course of infection (data not shown).

![Use of the chemical inhibitor of cysteine proteases E64 significantly reduced lesion size in MGAS5005Δ*srv* infected animals.\
Representative images of lesions formed in mice at 1, 3 and 8 days following subcutaneous infection with ∼2×10^8^ CFU of MGAS5005Δ*srv*. (A) The infecting dose of MGAS5005Δ*srv* was suspended in 333 uM E64 (0.1 ml), and lesion development (mm^2^) was monitored over 8 days (*n* = 10 mice). A significant


reduction in lesion formation was observed when E64 was inoculated with the infecting dose of MGAS5005Δ*srv* compared to inoculation with MGAS5005Δ*srv* alone (*p*\<0.05). (B) Following inoculation of animals with E64+MGAS5005Δ*srv* as before, an additional inoculation of 333 µM E64 (0.1 mL) was injected directly into the abscess each day following infection (*n* = 10). A significant reduction in lesion size was observed with E64 treated animals forming lesions roughly equivalent in size to untreated MGAS5005 infected animals.](pone.0018984.g009){#pone-0018984-g009}

To rule out the possibility that the reduced lesion size was due to the therapeutic effects of lavage, animals were infected MGAS5005Δ*srv* as before and receive daily 0.1 mL injections of saline directly to the abscess. While lesion size was reduced, it was not reduced to the extent of the E64 treated animals ([Figure10](#pone-0018984-g010){ref-type="fig"}). Thus, while lavage has a therapeutic effect, chemical inhibition of SpeB by E64 *in vivo* significantly reduces the virulence of MGAS5005Δ*srv*.

![Daily wound irrigation not responsible for the reduction in lesion size observed in E64 treated animals.\
Lesion size in saline treated animals (*n* = 3) was significantly reduced at 5 and 6 dpi compared to MGAS5005Δ*srv* infected animals (*p*\<0.05), however, lesions in saline treated animals were statistically larger than those in E64 treated animals at 2--8 dpi (*p*\<0.05).](pone.0018984.g010){#pone-0018984-g010}

Discussion {#s3}
==========

Previously, we have shown that the loss of the stand-alone response regulator Srv in MGAS5005 resulted in significant reduction of *in vitro* biofilm formation in both static and flow biofilm assays [@pone.0018984-Doern1], [@pone.0018984-Roberts1]. Furthermore, MGAS5005Δ*srv* exhibited reduced biofilm formation *in vivo* in a chinchilla model of otitis media [@pone.0018984-Roberts2]. The loss of


dose was confirmed by serial dilutions plated onto THY agar plates.

Murine subcutaneous infections {#s4c}
------------------------------

Studies were approved by the Animal Care and Use Committee of Wake Forest University Health Sciences. Five-week-old, outbred, immunocompetent, hairless female Crl:SKH1-*hr*BR mice (Charles River) received subcutaneous injections of ∼2.0×10^8^ CFU (0.1 ml) of either MGAS5005, MGAS5005Δ*srv* or MGAS5005Δ*srv*Δ*speB* at the base of the neck. Mice that received L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E64) (Sigma) treatment were given ∼2.0×10^8^ CFU MGAS5005Δ*srv* resuspended in 333 µM E64 (0.1 ml) at the time of infection. Those that were given daily treatments of E64 received 333 µM E64 (0.1 ml) injected at the site of infection beginning 24 hours post infection. Area of the lesion formed at the site of infection was measured daily using a caliper. The weight of each mouseare preparing for intense competition based on the delivery of data services. We currently expect the number of -G and -G customers to rise to --.-mn by the end of ----, equivalent to --.-- of the mobile subscriber base by the end of ----. We forecast broadband subscriptions to increase from -.--mn in ---- to -.--mn in ----, equivalent to a penetration rate of --.-- . Increasing competition and investment pose an upside risk to this forecast with more focused contribution to the broadband market by open access players to result in a medium-term surge of growth in the number of retail broadband subscriptions.

...We estimate that South Africa s mobile market had --.--mn mobile subscribers, reflecting a y-o-y increase of -.- and a q-o-q increase of -.- .


exchange and Bank fees from your financial institution as some banks and credit cards impose fees for international transactions outside the United States. If you have any questions about these fees or the exchange rate applied to your booking, please contact your bank.phenomenon of long-term potentiation (LTP; see Craver, 2005, 2007). Craver (2005, 2007) argues that this example of multifield mechanistic integration involved interlevel and intralevel components. The discovery of the phenomenon of LTP itself, according to Craver (2005), was an example of multifield, intralevel integration: the work of anatomists using Golgi staining combined with the work of electrophysiologists using microelectrodes to reveal aspects of cells at the same mechanistic level. If electrophysiologists were working with psychologists to find the neural correlates of learning and memory, then the discovery of LTP would have been an example of multifield, interlevel integration. But that is not what electrophysiologists were doing. When researchers started to think that LTP might be a component in a multilevel mechanism responsible for learning and memory, then multifield,


and Forstmann (2015, pp. 331-332) write that "our goal was to develop a model that could use prestimulus measures of brain activity to better constrain and inform the mechanisms assumed by a cognitive model of choice response time". Quotations such as these are replete in MBCN studies. 15 By providing mutual constraint from different scientific fields on the mechanisms that underlie and are responsible for cognitive processes, MBCN represents multifield mechanistic integration. This integration has multilevel and intralevel aspects. Building cognitive models that explain cognitive processes is a multilevel endeavor: the cognitive model posits representations and computational processes that are components of a mechanism responsible for the explanandum phenomenon.8 Cognitive modeling is the province of cognitive psychology, a component field of MBCN. Finding implementations of those representations andmakes explicit why adding implementational details does not constitute interlevel mechanistic integration: to add implementational details is to extend the set of causal powers possessed at a single mechanistic level beyond the set picked out by a functional concept. The causal powers contained in the proper superset (i.e., the causal powers in the superset not contained in the subset), while they may be functionally irrelevant, can often be used to identify the potential realizer. For example, SUSTAIN's concept of recognition strength picks out certain causal powers, and the concept MTL network picks out certain causal powers. The former are a subset of the latter. That is what it means for the MTL network to play the recognition strength role. The causal powers in the proper superset include all


J. P., & Anderson, J. R. (2013). Using model-based functional MRI to locate working memory updates and declarative memory retrievals in the frontoparietal network. Proceedings of the National Academy of Sciences of the United States, 110, 1628–1633. https://doi.org/10.1073/pnas.1221572110 Borst, J. P., & Anderson, J. R. (2017). A step-by-step tutorial on using the cognitive architecture ACT-R in combination with fMRI data. Journal of Mathematical Psychology, 76, 94-103. https://doi.org/10.1016/j.jmp.2016.05.005 Carlson, T., Goddard, E., Kaplan, D. M., Klein, C., & Ritchie, J. B. (2018). Ghosts in machine learning for cognitive neuroscience: moving from data to theory. NeuroImage, 180, 88100. https://doi.org/10.1016/j.neuroimage.2017.08.019 Coltheart, M. (2006). What has functional neuroimaging told us about the mind (so far)? Cortex, 42(3), 323-331. https://doi.org/10.1016/s0010-9452(08)70358-7 Chirimuuta, M. (2014). Minimal models and canonical neural computations: The distinctness of computationaland bone resorptionPSG\[[@CR45]\]Collagen protein *COL1A2*Collagen Type I Alpha 2 ChainAbundant and widespread: dermis, bone, tendon, ligamentPSG (rib)\[[@CR46]\] *COL2A1*Collagen Type II Alpha 1 ChainCartilage, vitreousDSG *COL3A1*Collagen Type III Alpha 1 ChainSkin, blood vessels, intestinePSG, DSG (rib) *COL5A2*Collagen Type V Alpha 2 ChainBone, dermis, cornea, placentaDSG (humerus) *COL9A1*Collagen Type IX Alpha 1 ChainCartilage, cornea, vitreousDSG *SPARC*OsteonectinRequired for the collagen in bone to become calcifiedDSG\[[@CR47], [@CR48]\]Osteoblast differentiation and function *HES1*Hes Family BHLH Transcription Factor 1Inhibiting osteoblast function and inducing bone resorptionDSG\[[@CR49]\] *RUNX2*Runt-related transcription factor 2Transcription factor driving osteoblastogenesisDSG\[[@CR50], [@CR51]\] *MEPE*Matrix Extracellular PhosphoglycoproteinMineralization, phosphate regulation and osteogenesis.PSG\[[@CR52]\] *STAT1*Signal Transducer and Activator Of Transcription 1An important role in endochondral bone formation and chondrocyte differentiationDSG\[[@CR53]\]Osteoclast differentiation and function *TEC*Tec Protein Tyrosine KinaseActivated by RANKL and Indispensable for osteoclastogenesisDSG, PSG (humerus)\[[@CR54]\] *LCP2*Lymphocyte Cytosolic Protein 2Adaptor molecules in osteoclastogenesisDSG (humerus) *FOSL1*FOS Like 1, AP-1 Transcription Factor SubunitInduces transcription of


protein-coding genes correlating with bone variables (regression analysis, vs. 'root-to-tip' *d*~N~/*d*~S~). Lines between nodes indicate inferred or experimentally demonstrated biological associations. Humerus, rib, and vertebrae are indicated in yellow, beige, and brown respectively. Genes also under positive or divergent selection are indicated in maroon and purple, respectively. **b.** Heat map of genes correlating (green, positive; red, negative) with bone variables (regression analysis, vs. 'root-to-tip' *d*~N~/*d*~S~). Genes in the osteoclast differentiation pathway are highlighted in pink. For selected genes, a plot of bone variable (vertical axis; please see main text for details) and substitution rate ('root-to-tip' dN/dS) is shown; with salmon, blue, and green indicating species in an aquatic, flying, and terrestrial habitat, respectively

The association of 'root-to-tip' *d*~N~/*d*~S~ with bone mass parameters and the selective pressure analysis both identifiedselected gene in the cetacean lineage of interest is *TNFRSF1A* (also known as *TNFR1*), the only gene with a 'root-to-tip' *d*~N~/*d*~S~ negatively correlated with *Cc* (*P value.robust* = 3.93 × 10^− 05^, *r*^2^ = 0.49). *TNFRSF1A* is the receptor of TNF-α and modulates immune and inflammatory processes, as well as bone homeostasis \[[@CR58]\]. Cross-talk between interferons and other cytokines in bone remodeling have recently received greater attention. For example, one of the IFN-β receptor components in the type I interferon system is *IFNAR1* **(**Table [1](#Tab1){ref-type="table"}**)**. *Ifnar1*^−/−^ mice have markedly reduced trabecular bone mass, a key feature of osteoporosis, suggesting that the gene plays a critical role in osteoclastogenesis \[[@CR56]\]. We hypothesize that bone homeostasis in aquatic mammals is maintained by the *RANK*-*RANKL*-*OPG* axis acting in concert with cytokines.

In summary, we have identified a correlation between


of North Carolina, Raleigh, North Carolina, U.S.), Shoji Hayashi (Okayama University of Science, Okayama, JAPAN), Michel Laurin and Alexandra Houssaye (Muséum national d'histoire naturelle, France), who have agreed or given bone images for the present study. We thank Xuanmin Guang and Wencai Jie for helping learning with Perl and R coding. We are especially grateful to Siming Ma and Lin Zhang for giving advice on the statistical analyses. Many thanks are also given to Yunxia Yang, Zhengfei Wang, Kangli Zhu, Ran Tian, Zepeng Zhang, Simin Chai, Yuan Mu and Yulin Gai for support and discussions.

GY and SX designed the study. DS performed sample collection and data analysis, then prepared the draft of the manuscript. XZ participated in the design of the methods of PGLS and the writing ofodyssey which would last for several years.

Post Crisis
After the Crisis on Infinite Earths limited series abolished the DC multiverse for a time, he was retconned into a 20th-century Durlan and founding member of the intergalactic police force L.E.G.I.O.N.. For a short time he works with such members as Garryn Bek, Vril Dox and Stealth in their early efforts to establish an interplanetary peacekeeping force. He is then brought forward in time to the 30th century by the villainess Glorith; as part of the necessary elements of the transfer, he is switched with the now amnesiac Phantom Girl.

Post-Zero Hour
R. J. Brande now creates stargates instead of suns, but plays much the same role in the Legion's origins. Brande was originally planned to be revealed as the Martian Manhunter, but


construed as a potential conflict of interest.

Appendix. Supplementary materials {#sec0014}
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Image, application 1

Authors wish to thank the Ministry of Health & Family Welfare, Government of India for helping with the data collection in this study.

Supplementary material associated with this article can be found, in the online version, at [doi:10.1016/j.chaos.2020.110154](https://doi.org/10.1016/j.chaos.2020.110154){#interref0003}.
planet," Mr Nuttall told the BBC's Andrew Marr Show.

"We're the most watched and for that to be effective you need to see people's faces.

"Secondly, there's the issue of integration - I don't believe you can integrate fully and enjoy the fruits of British society if you can't see people's faces."

Asked why Ukip had changed from its 2013 stance, when Mr Nuttall said the party would not pursue a blanket ban against face-covering veils, Mr Nuttall said: "There's obviously the bigger security threat that we face now.

"But you look at Trevor Phillips' report last year into Muslims in the UK, you look at the work that Dame Casey has done on this issue - integration is actually getting worse in Britain at the moment, not better. This will help."

France


by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photo by Vlad Savov / The Verge

Photography by Vlad Savov / The Vergewhich could have helped black holes back then gorge on "an almost continuous inflow of gas without 'burping' too much of it back into the galaxy," Trakhtenbrot said.

Trakhtenbrot and his colleagues now want to analyze more similarly ancient supermassive black holes to learn more about their interplay with their galaxies.

The results appear in the July 10 issue of the journal Science.

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