           }
        }
    }
    default void Handle_MouseEventRedirectToParent(MouseEvent event) {
        if(event.isPrimaryButtonDown()) {
            //Redirect to the containing group.
            if(event.getSource() instanceof Cell) {
                Cell cellSource = (Cell)event.getSource();
                if(cellSource.containerProperty().get() instanceof Node) {
                         ex.printStackTrace();
                //we just won't be able to account for the translation.  There may be some distortion, but it will still work.
            }
            final Point2D ptTranslated = ptTemp.subtract(dragContext.ptOrigin);

            ((Node)this).setLayoutX(((Node)this).getLayoutX() - dragContext.ptPrevious.getX() + ptTranslated.getX());
            ((Node)this).setLayoutY(((Node)this).getLayoutY() - dragContext.ptPrevious.getY() + ptTranslated.getY());

            //To avoid floating point rounding errors we will reverse this translation and apply


is thought to activate autophosphorylation at tyrosine Y-749, Y-753 and Y-754 in the tyrosine kinase domain, which in turn activates the molecular cascade targeting actin or non-muscle myosin II to coordinate the cytoskeletal rearrangements necessary for phagocytic ingestion[@b25].

In this study we describe the generation of an *in vitro* model of RP caused by the mutation of *MERTK* gene using human iPSC technology. We report the generation of a cellular model of MERTK-associated RP, which recapitulates the disease phenotype described in animals and in patients and provides a tool to advance our understanding of the signaling pathways activated by MERTK. Importantly this can be studied in detail in the context of the human genetic background, a crucial feature of the cellular model. Equally important is that it provides us7 (NM_006343.2), at position 992_993 causes the frameshift resulting in a premature stop codon at position 335 ([Supplementary Fig. S1B](#S1){ref-type="supplementary-material"}). The predictive stop codon results in a truncated protein with 2 Ig-like domains and part of the first FN3-like domain with no kinase activity ([Fig. 1B](#f1){ref-type="fig"}).

Generation of iPSC from healthy individual and RP patient
---------------------------------------------------------

The primary fibroblasts derived from the skin biopsies were expanded for three to-five passages before being reprogrammed by a Sendai viral construct containing four genes: Oct3/4, Sox2, Klf4 and cMyc ([Supplementary Fig. S2A](#S1){ref-type="supplementary-material"}). This construct described as highly efficient in transduction was selected for being non-integrative and replication deficient. Thirty days after transduction, iPSC colonies were selected by their morphology (refractive edges, high nuclear/cytoplasmic ratio) and *in situ* staining of pluripotency markers (TRA-1-60 or TRA-1-81).


iPSC-RPE monolayers from both individuals to fluorescently labeled bovine and pig OS and monitored their ingestion by confocal imaging. [Figure 4](#f4){ref-type="fig"} shows the internalization of OS by the iPSC-RPE from the healthy individual while this was completely lacking in the case of the RPE generated from the RP patient. The labeled phalloidin depicts the abundant F-actin in the microvilli and the OS are detected in the region of microvilli and inside the cells derived from healthy individual. Vertical sectioning demonstrating the ingested OS phagosomes inside the cells is shown on [Supplementary Fig. S8](#S1){ref-type="supplementary-material"}. The patient's iPSC-RPE monolayer showed only a few OS in the area of microvilli. Both iPS cell lines derived from the RP patient exhibited the same defect in phagocytosis of OS upon differentiation to RPE.

Wehave thus generated patient-specific RPE cells that lack the expression of MERTK and consequently recapitulate the MERTK deficient phenotype i.e. absence of phagocytosis. These data show that patient-specific, mature and functional RPE can be generated from control and RP patients via iPSCs. The monolayers derived from the two individuals as reported here are morphologically identical and indistinguishable by RPE-specific marker expression while preserving patient's identity as observed by distinctive MERTK expression and its associated function.

Discussion
==========

Retinal dystrophies comprise a group of eye diseases caused by mutations in a spectrum of genes with a specific function in photoreceptors or RPE cells or in many cases mutations in ubiquitously expressed genes that exclusively give rise to a retinal phenotype. While retinal tissue is inaccessible for the studies of molecular mechanism, unrelated


HGMD public database (last accessed January 8, 2015). We show here the successful generation of iPSC from a RP patient bearing a novel p.Ser331Cysfs\*5 mutation in MERTK which has not been described before. Adult dermal fibroblasts were reprogrammed with non-integrative virus delivering pluripotency genes and the generated iPSCs maintained genomic integrity throughout the culture period of over 30 passages. It should be noted that genomic alterations including numerical and structural alterations are not uncommon in iPSC cultures. In our experience the use of Sendai virus as a vehicle for gene delivery resulted in the absence of genomic alterations in contrast to integrative viral strategies. As demonstrated here, iPSCs established from the control and the affected patient were identical in relation to reprogramming efficiency and exhibited similar kinetics andfor mutations. Exons and exon--intron boundaries of *MERTK* were analyzed using oligonucleotide primer pairs designed using Primer3 software (<http://frodo.wi.mit.edu/>). Sequences and annealing temperatures are available from the authors on request. The PCR conditions and primer sequences are available on request. The PCR products were enzymatically purified with ExoSAP-it (USB, Affymetrix) and both strands sequenced using Big Dye Terminator Cycle Sequencing Kit version 3.1 (Applied Biosystems, Carlsbad, CA). The PCR products were purified in a 96-well multiscreen filter plate (Montage SEQ96 Sequencing Reaction Cleanup Kit; Millipore, Bedford, MA) and resolved on an automated sequencer (ABI 3130xl Genetic Analyzer, Applied Biosystems).

Direct sequencing in fibroblasts and iPSCs: Genomic DNA from fibroblasts and iPSCs was isolated using the QIAamp DNA Blood mini kit (Quiagen). Primers used for amplification and directed sequencing of


iPSC-RPE from each individual are analyzed. The expression of CRALBP and BEST1 is detected only in iPSC- RPE and hRPE cells. β actin was used as loading control. Cropped blots are from gels run under the same experimental conditions and loaded with the same samples.](srep12910-f3){#f3}

![*In vitro* phagocytosis assay of photoreceptor outer segments (OS) by iPS-RPE from healthy individual and MERTK p.Ser331Cysfs\*5 patient.\
Basolateral sections across the iPSC-RPE cells together with vertical section simulation. Healthy iPS-RPE internalize FITC-labeled OS (green) while patient's one do not. F-actin is stained by phalloidin (red) to visualize cell morphology. Images were taken with Leica confocal microscope TCS SP8 using HCX PL APO lambda blue 63X/ 1.4 OIL objective, scale bar 25 μm.](srep12910-f4){#f4}
    $sql .= "`${key}`, ";
            $values_sql .= "?, ";
            $values[] = $value;
        }
        $query = substr($sql, 0, -2).substr($values_sql, 0, -2).")";
        return $this->query($query, $values);
    }

    public function close() {
        $this->dbh = null;
    }
}

Now I call the following:
$insert_statement = $dbh->insert("users", array(
    "email" => $email,
    "password" => $password,
    "ingame" => $ingame,
    "kiosk" => $kiosk
));

Is there a way


Rip off the mask, tear down the walls. Show the world my beautiful, vulnerable self!

Archive for the ‘healthy’ Category

Last week, I was a sad mess, but after just one week, this simple happiness prescription has turned my life around! Do you want to be happy too? Well, stick around for a bit and I’ll tell you what to do!

For only $19.95 and 30 minutes a day, 4 times a week…

No, wait a minute! That’s not it! Rewind! Take 2!

Are the holidays getting you down? Are you dragging from one day to the next, barely able to put one foot in front of the other? Do you want to spend your days holed up in your house, wearing the same pair of smelly pajamas you’ve worn for the lastalready sore foot (if you can show me a dance addict who hasn’t done that a time or two, I’ll kiss their shoes!) gave me an unexpected day of little activity as I paid the price by needing to stay off of it entirely for awhile. I even had to decline the opportunity to start learning a new kind of dancing, much to my disgust! But I promised myself and my friend, Dezi that I will soon accept the challenge of learning Casino Rueda while taking another step out of my cozy little comfort zone.

However, the day was not a total bust. I finally got my computer checked out and was assured that most of my problem was the accumulation of dust inside the case. I am also


with the delightful woman who does my nails. Sometimes, our conversations are pretty benign, and others, we might be solving all of the problems of the world. But it really doesn’t matter what we talk about. I enjoy the hour every couple of weeks that is all about me. She puts me back together when I’ve had a couple of casualties, and just having nice hands makes me feel that much better about myself. Sure, it’s a little thing, but isn’t most of what makes us feel good just a compilation of little things?

Shopping for decorations and a gift for my daughter’s birthday is definitely extraordinary. It wouldn’t matter if I’d done it twenty times, or a hundred and twenty. Labors of love are like that, you know!Grant Kereama was introduced to almost all The Hits stations. A local show between 9am and 3pm was then introduced and presented by Andy Mack. Following his departure, Israel Bai took over the local show. With Polly and Grant leaving The Hits in 2017 all South Island stations reverted to local breakfast programming. Currently there is no local programming on the station and it is entirely networked.

Today the station now known as The Hits West Coast can be heard on the following frequencies.
 90.5FM - South Westland
 90.9FM - Westport
 90.7FM/93.1FM - Greymouth & Hokitika
 97.5FM - Reefton

References

West Coast
Category:Media in Greymouth
Category:Defunct radio stations in New Zealand


parental HCC827 cells, (2) A549 cells treated with 1 μg/mL of BBI608 and 1 μg/mL of YM155, and (3) A549shSTAT3 and A549shG9a compared with A549shLuc (luciferase). A HiSeq 4000 with paired-end 150-bp sequencing was used for experiments. Genes upregulated with a \> 2-fold change (log2) with a *p* value of \< 0.05 in HCC827-derived tumorspheres were selected for bioinformatics analyses by using NetworkAnalyst (<http://www.networkanalyst.ca/>) \[[@CR28]\], and pathway activations were selected and matched based on the KEGG database. Genes downregulated with a less than − 1-fold change (log2) with a *p* value of \< 0.05 in (1) BBI608- and YM155-treated A549 cells compared with parental A549 cells and (2) A549shSTAT3 and A549shG9a compared with A549shLuc cells were compared using List Operations (<http://www.molbiotools.com/listoperations.html>) to determine common genes that were differentially expressed. In addition, differentially expressed genes werewas used to calculate the G9a, di-mH3K9, HER3 ratio divided by GAPDH.

Cell viability {#Sec9}
--------------

The Alarmar Blue assay was performed according to manufacturer's instructions to determine cell viability. To find therapeutic agents that can be applied against EGFR-positive lung cancers, a panel containing 172 compounds targeting stemness (MCE, Monmouth Junction, NJ, USA) was added to HCC827, A549, H1975, and H520 cell lines separately at doses of 1 μM and incubated for 48 h. To examine cell viability, cells were treated using afatinib, BBI608, or YM155 for 48 h.

Cell migration {#Sec10}
--------------

Transwell migration assay (8 μm) was used to detect A549 cell migration capacity. In brief, 5 × 10^4^ cells were placed in the upper layer of a cell culture insert with 200 μL of serum free DMEM medium. To test cell migration of A549-derived tumorspheres, serum-free DEME


medium containing B27 (Invitrogen, Waltham, MA), 20 ng/mL of EGF (Sigma, Missouri, TX), 20 ng/mL of fibroblast growth factor (bFGF, Sigma), 5 μg/mL of bovine insulin (Sigma), and 4 μg/mL of heparin (Sigma) was used. Then, each 750 μL of DMEM medium with 10% FBS and test agents, including 1 μg/mL BBI608, 1, 5, 10 μg/mL UNC0642, was loaded into the below 24-well culture plate. Cells were incubated at 37 °C and 5% CO~2~ for 16 h. The membrane inserts were fixed in 3.7% formaldehyde for 5 min and consequently incubated in 100% methanol for 20 min at room temperature. After 0.5% crystal violet in 2% ethanol to stain the membrane inserts for 15 min at room temperature, non-migrated cells on the upper membrane were scraped with cotton swabs. PBS wash for twice was necessary between operations. The cells migratedexhibited the simultaneous autophosphorylation of EGFR and increased phosphorylation of STAT3 than in other cell lines (Fig. [2](#Fig2){ref-type="fig"}c). In addition, a panel containing 172 therapeutic agents targeting genes associated with various stem cell pathways was used, and the viability of each cell line was measured after incubation with 1 μg/mL of therapeutic agents for 48 h. The results are presented in Additional file [9](#MOESM9){ref-type="media"}: Figure S1. BBI608, a stemness inhibitor targeting the STAT3 pathway, significantly reduced selected EGFR-positive cell lines, with a cell viability less than 40%. In addition, BIO targeting of CDK1 and GSK-3 reduced HCC827 and H1975 cell viability. Sanguinarine targeting of ERK particularly reduced A549 cell viability. The compound static targeting of STAT3 and halofuginone targeting of TGFβ/smad reduced cell viability both in A549 and H1975 cells. TG101209 targeting of


BBI608 also inhibited tumor growth in A549-derived tumor xenografts in vivo (Fig. [2](#Fig2){ref-type="fig"}h). The results revealed that BBI608 was a potential therapeutic agent against lung cancer. Fig. 2BBI608 significantly inhibited cell viability in EGFR-positive lung cancers, including EGFR E746-A750 HCC827, wild-type (WT) A549, and T790 M H1975. **a** EGFR-positive HCC827, A549, and H1975 and EGFR-negative H520 lung cancers were selected for use in identifying potential therapeutic agents. HCC827 with EGFR E746-A750 mutation triggers TKIs, whereas A549 and H1975 bearing KRAS and T790 M mutations, respectively, are resistant to TKIs. **b** Results from qPCR revealed that *ERBB3* was expressed in HCC27, A549, and H1975 at higher levels than in H520 cells. In particular, H1975 showed the highest *ERBB3* expression level. **c** The results of Western blot analyses demonstrated and validated that H1975addition, UNC0642 targeting G9a reduced cell migration of A549 cells in a dose-dependent manner (Fig. [5](#Fig5){ref-type="fig"}i and j) and induced A549 cell apoptosis (Additional file [12](#MOESM12){ref-type="media"}: Figure S4). Fig. 5G9a induced *ERBB3* expression via the repression of miR-145-5p. **a** Western blot analysis revealed that the knockdown of ILF3 and G9a led to a reduction in HER3 (*ERBB3*) expression in A549 cells. There was a reduction of G9a in A549ILF3 cells, whereas demethylation of H3K9 presented G9a activity. **b** The gene cluster profiles in A549shILF3 and A549shG9a were listed and compared following small RNAseq analysis, **c** which revealed that 124 and 75 miRNAs were upregulated and downregulated, respectively, in A549shILF3 (Additional file [7](#MOESM7){ref-type="media"}: Table S7), and 62 and 48 miRNAs were upregulated and downregulated, respectively, in A549shG9a cells compared with A549shLuc cells (Additional file [8](#MOESM8){ref-type="media"}: Table


Q:

Which toolkit should I use to make an easily editable and modern looking GUI for existing c++ code?

I am starting a new small project where the graphic interface and a bit of juggling data too and fro is missing, but the complex and time-critial parts of the code exist and are written in c/c++. Previously I've used the win32 api, MFC to do the graphics, but I want something a bit more modern looking and newer and something that is a bit simpler to maintain and update. I should probably mention that I also want to try out and learn something new...
A few years ago I tried integrating c++ components to c# using pinvoke. It turned out quite messy. But that was a long time ago...
Any tips? Whatfor such galaxies photometrically from SDSS with colour cuts , , and (compare e.g. @high). While requiring a match of at least one of these galaxies in the SDSS DR8 with the RASS sources and adding these cases to our preselected sample we find 1395 candidates in total.

In the next step all candidates are visually inspected using SDSS postage stamps and graded. Here we immediately drop obvious chance alignments of background galaxies e.g. with bright foreground stars, spectroscopically classified QSOs, or low-$z$ galaxy groups, which most likely dominate the X-ray flux. In addition, we drop sparse galaxy groups/clusters, where the SDSS colours suggest . At these redshifts we would still expect to detect numerous cluster galaxies in SDSS if these were massive clusters. Hence, these sparse groups/clusters likely


majority of our optical follow-up observations were taken with the Auxiliary-port CAMera (ACAM) [@acam] on the 4.2-m William Herschel Telescope on the island of La Palma in Spain. ACAM is a red-optimized one chip camera with $2148\times2500$ pixels which has an unvignetted circular field of view of about $8\arcmin$ in diameter and a pixel scale of $0\farcs25$.

Our WHT data were taken in service mode (August 2010 and August 2013, PIs Schrabback and Buddendiek, respectively), and in visitor mode (four nights each in August 2011 and March 2012, PI Schrabback). We obtained imaging in $r$, $i$, and $z$ filters, which bracket the $4000\,\rm{\AA}$-break in the redshift range of interest. The service observations in 2010 were carried out with the RGOZ2 filter ($\lambda_{\rm{central}}=8748\,\rm{\AA}$) as the SDSS $z$-band was not yetz \lesssim0.9$. Additionally, we extrapolate these models to $z=0.4$ and $z=1.0$. [[ We are aware that the red sequence slope and off-set do not in general vary linearly with redshift. Nevertheless, this assumption provides a good approximation given the redshift range and filter choice.]{}]{} The models created can be used for both the WHT and the LBT sample, because their filter sets are fairly similar; for the service observations in 2010, we create models in the same way but using different clusters, due to the different filters used. [[ The clusters used [[ to create the models]{}]{} for the WHT and LBT samples spread almost evenly in the [[ redshift range between]{}]{} $z\approx0.55$ and $z\approx0.9$. For the models for the WHT service observations we only have redshifts available


to the best-fitting values of the ‘universal pressure profile’ found by @arnaud.

![Redshift and richness distribution of all 44 galaxy clusters in our sample and of the three previously known objects. Wherever available we use spectroscopic redshifts. Light grey bars show the whole sample, dark grey bars the SZ-detected clusters only.[]{data-label="fig:distros"}](./fig4.pdf){width="8cm" height="5.6cm"}

We reduce the CARMA data using a pipeline similar to the one used in @mucho, which was adapted for the use with CARMA. We first filter out bad weather errors as well as pointing errors and then apply a gain and flux calibration. For the flux calibration we use the model of Mars from @rudy87. We assume that Mars is a disc of uniform brightness, Fourier transform this disc to the visibility plane and compare it to thesurvey. To compute these lines we use the fitting formula from @mortonson and acknowledge the fact that this gives too strict limits. The solid points show the masses estimated in this study. The other symbols represent masses from previous studies. Arrows indicate the upper limits we find in CARMA for non-detected clusters. We find no tension with the $\Lambda$CDM model. The open circles are the 10 most massive clusters between $0.6<z<1.0$ from @bleem, the triangles with the tip down show the 10 most massive clusters in this redshift range in the *Planck* SZ sample [@planck_sz]. []{data-label="fig:mass_limits"}](./fig8.pdf){width="8.5cm" height="8.5cm"}

We plot the cluster masses against redshift in . Additionally, the masses of three clusters from previous studies are plotted (see Section \[sec:sz\]). Furthermore, we take the 10 most massive clusters at


doesn’t really struggle that greatly with self-awakening anymore either, alongside Instant Transmission which we’ll see later. So this Bardock doesn’t even offer anything that Draft Box Bardock doesn’t do better and as a card in of itself…seriously, just play Cell instead since his abilities are almost exactly the same as well but far less restrictive.

Son Goku/Legacy Bearer Son Goku

Now this one could also be argued for the above, due to Goku taking the designs of the majority of Universe 7 Leaders from Tournament of Power and put them all into one package. But in this instance it actually leads to at least some interesting design. His front side is essentially U7 Goku/Gohan/Frieza all together into one neat package. He needs an attack (like U7 Gohan due to needingGoku. A 3 Drop that Untaps 2 Energy. But she has other upsides without the Barrier, or being a Saiyan. She gets to mill if she wants, again for OR strats or Meta-Cooler and the like this could be helpful. It is optional though. She also gets to draw, which continues the Bulma Cantrip legend. She’s another proactive 3 drop, which is nice for Yellow but nothing over the top either. She can definitely find room in some strategies.

Multimech Bulma

This Bulma is only considered an EX-Evolve due to needing a 3 drop or higher Bulma, otherwise she’s classic Evolve all the way. It’s also a GOOD thing she requires that, otherwise she’d be really stupid. Anyway, pretty damn similar to the above. More drawing, more potential milling, a


the archetype anyway outside of maaaaybe At the Apex so it shouldn’t cause too much harm.

10x Kamehameha

Here Goku, have a stronger Champa. This is basically what this is, giving Goku’s with the Lineage their own Champa but even stronger. Seems busted…but honestly doesn’t come close to using Champa with Vegeta or Masked Saiyan. Yeah on SS4 Goku’s Awakened Side (hence, you know, the name and art) but that takes a while to setup. It is also a 15K combo in general though, so it may be used regardless as just extra defensive power when you’re not trying to get in for Double Strike. Probably shouldn’t overlook it.

Instant Transmission

…well, I guess we can assume this is going to be a cycle in all the colors (outside of Black maybe).// Copyright (c) 2018 Intel Corporation
//
// Permission is hereby granted, free of charge, to any person obtaining a copy
// of this software and associated documentation files (the "Software"), to deal
// in the Software without restriction, including without limitation the rights
// to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
// copies of the Software, and to permit persons to whom the Software is
// furnished to do so, subject to the following conditions:
//
// The above copyright notice and this permission notice shall be included in all
// copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
// IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
// FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
// AUTHORS


defined urgent if performed less than 24 h after revealing the problem, while it was defined elective COR if performed after that time. Out of that database, we retrospectively analysed 22 patients treated with COR (5% out of our 435 EVAR). Additionally, we studied the available history of two patients undergoing EVAR in other centres. All 24 cases underwent late COR with graft removal \>30 days after EVAR: two other patients were excluded from the study because they were early CORs. Every patient's physical status was assessed according to American Society of Anaesthesiologist score (ASA).

Within operative details, we evaluated the kind of surgical approach performed, position and duration of the proximal aortic cross-clamping, total or partial graft explanation (conversion vs. semi-conversion). Post-operative variables included major perioperative (30 days) morbidity14.3
   Aortoenteric fistula        1     14.3

Indications {#sec6-2048004017752835}
-----------

The most frequent indication for COR was type I endoleak with (n = 10). Other indications included type III (three cases) and persistent type II, with an aneurysmal sac enlargement of at least 5 mm (seven cases). We also found two cases of endotension. Therefore, the overall indication for endoleak was about 96%. The last case was one infection with aorto-enteric fistula ([Table 2](#table2-2048004017752835){ref-type="table"}). Overall, three cases (12.5%) were treated in emergency settings: the infected EVAR and two aortic ruptures for type I B endoleak and type III, respectively. Notable, both aortic ruptures occurred after regular follow-up checks, with no signs of major complications until that event.

Operative details {#sec7-2048004017752835}
-----------------

We chose a midline abdominal


quality of life, as measured by the 36-item Medical Outcome Short-Form Health Survey (SF-36), were poorer among patients with depression (n = 319) with respect to the non-depressed general population (n = 2,486), with the poorest level reached by patients with MDD (n = 205). Data indicating that the severity of depression was significant in negatively influencing the quality of life of patients has been confirmed by Trompenaars *et al*. \[[@B5]\], who showed lower levels of quality of life among patients with major depression with respect to those with dysthymia and adjustment disorders.

A large population-based study involving 60 countries has also indicated that depression had the largest effect on worsening mean health scores compared with other chronic conditions, including physical diseases, and that patients with depression comorbid withand social variables, need to be studied in a prospective way.

Recent results have been reported by the European Union Factors Influencing Depression Endpoint Research (EUFINDER), a 6-month, prospective, observational study carried out in 12 European countries, aimed at assessing the changes of health-related quality of life (HRQoL) in outpatients receiving pharmacological treatment for a depressive episode in routine primary care and specialist settings. The study, carried out on 3,468 adult patients with a clinically diagnosed episode of depression, seems to demonstrate that receiving an antidepressant (AD) treatment was associated with improvements in HRQoL, as assessed by the 36-item Short Form Health Survey (SF-36) and the European Quality of Life-5 Dimensions (EQ-5D) \[[@B8]-[@B10]\]. The baseline results of patients in the FINDER study in Italy, enrolled only by specialists, have


= -1.16; *P*= 0.034 95% CI -2.23 to -0.09). This means that patients with a higher baseline SSI somatic score had poorer physical QOL outcomes. PCS was also less improved in patients suffering from a chronic medical condition (estimate = -1.61; *P*= 0.009; 95% CI -2.80 to -0.41) and in patients who presented any psychiatric illnesses in the 24 months before baseline (estimate = -1.42; *P*= 0.044; 95% CI -2.80 to -0.04). Better PCS scores were associated with use of an SNRI (estimate = 3.24; *P*= 0.014; 95% CI 0.66 to 5.82) or \'other drugs\' (estimate = 3.82; *P*= 0.018; 95% CI 0.67 to 6.97) baseline and 3-month observation compared to TCA. PCS improvement was also statistically associated with HADS-A score at baseline (estimate = 0.24; *P*= 0.009;finding is that the presence of a previous psychiatric illness in the 24 months before baseline was predictive of poorer HRQoL outcomes, with respect to EQ-5D VAS and, to a lower degree, to SF-36 PCS.

Another result of our study indicates that a higher severity of somatic and painful symptoms at baseline, as evaluated by patients, was associated with poorer HRQoL outcomes during antidepressant treatment. We also found that the presence of a chronic medical disease is associated with poorer HRQoL, as far as SF-36 PCS and EQ-5D HSI are concerned. This confirms other research highlighting the role of somatic and painful symptoms in the QOL of depressed patients and their possible implications on depression outcomes \[[@B7],[@B10],[@B18],[@B19]\].

There are some limitations that need to be considered in interpreting the results


presenting acute or subacute cervical radiculopathies. Based on biomechanical principles, our hypothesis is that the rehabilitation program targeting the opening of intervertebral foramen will be significantly more effective in reducing pain and disability than the conventional rehabilitation program, mainly at the 4-week evaluation. In considering the passage of time, the differences between the two interventions should be less important at 8-week.

Methods/Design
==============

Study Design
------------

This double-blind randomised clinical trial will allow the comparison, in terms of pain and disability, of patients presenting a cervical radiculopathy which will have been randomly assigned to one of the two intervention groups: the first group (n = 18) will receive a 4-week rehabilitation program targeting the opening of intervertebral foramen, the second group (n = 18) will receive a 4-week conventional rehabilitation program. Participants willmobilisation techniques, there will be two mandatory techniques targeting the opening of the intervertebral foramen on the same side and at the same level as the radiculopathy: global contralateral rotation mobilisation and ipsilateral lateral glide in a flexion position (10 repetitions \* 30 seconds for each technique). The physiotherapist, according to the biomechanical evaluation results, will choose the two other mobilisation techniques including rotations, lateral glides, postero-anterior glides, infero-medial glides or supero-anterior glides mobilisations.

• The third exercise of the home program will be an opening technique: contralateral rotation exercise (contralateral to the affected segment; 10 repetitions \* 3 seconds, 10 times/day).

Therefore, the number of mobilisation techniques and home exercises will be the same for the two intervention groups.

Sample size and Analyses
------------------------

The sample size calculation is based on the


        curl_setopt($ch, CURLOPT_HTTPHEADER, Array("Content-type: application/binary"));
                        curl_setopt($ch, CURLOPT_POSTFIELDS, $data);
                        curl_setopt($ch, CURLOPT_POST, 1);
                        $response = curl_exec($ch);
                        if (curl_errno($ch))
            on google's database
                    if ($lat == 0 and $lon == 0)
                        exit('ERROR: cannot determine cell tower location from cell LAC: ' . $_POST["lac"] . ', ' . 'CID: ' . $_POST["cid"]);

                    $addr = ''.$lat . ',' . $lon;
                    $t = urlencode(" (MCC=$mcc MNC=$mnc LAC=$lac CID=$cid)");


//echo "
Lat=$lat Lon=$lon";
                }
            ?>

            <form method="post" action="<?php echo $_SERVER['PHP_SELF'];?>">

MCC
                            <input type="text" size="5" name="mcc" value="<?php if(isset($mcc)) echo $mcc; else echo ""?>">
to glare with suspicion on the unknown.

"Who are you?" he asks. "Are you lost?"

"A traveller," Remy replies. "Not lost; just wandering."

Ah! Revelation dawns in the elder's face, for he knows, though he has never met anyone like this before, that foreigners go very easily mad in hot climates, and here clearly is a deluded poor fool struck down by too much sun.

"Come inside, come into the shade," he commands. "Eat with us, eat!"

Remy obeys.

# Chapter 12

Remy ate rice in the shade.

Took off his boots.

Rubbed the blisters, put his boots back on before he could scratch them until they burst.

Found a leech feeding busily against his calf.

Knocked it carefully off. Do not pinch it at the back, or squeeze too hard. Do not scald it with fire or salt.


for a favour not yet disclosed. He who giveth, so they say, can taketh away.)

"This is not the man you are looking for," Silver explained to the captain, indicating Remy. "Please inform your men of this fact."

The captain nodded again, then turned to his soldiers, wrenching his eyes from Silver's face as if from the leering gaze of a corpse, and barked, "Wrong! Wrong – didn't you pay attention? These are not the men – wrong! Go back to your posts!"

The soldiers obeyed.

Silver walked Remy out of the doors of the station and together they stood for a moment in the porch, looking at the pouring rain. Silver's eyes wandered upwards as if trying to read the motion of every drop that fell. Remy watched him a while,be athletically grown and physically more active) were found to have metabolic syndrome (p=0.553). We suggest firstly here that sedentary palace lifestyle exacerbated metabolic syndrome in Ottoman dynasty especially in elderly members, thereafter complicated by cardiovascular events, even in pre-modern era.


 and-int/lit8 v0, v0, 0x1

    if-ne v0, v2, :cond_0

    iget-object v0, p0, Lcom/appbrain/e/r;->c:Lcom/appbrain/e/h;

    invoke-virtual {p1, v2, v0}, Lcom/appbrain/c/e;->a(ILcom/appbrain/c/o;)V

    :cond_0
    move v0, v1

    :goto_0
    iget-object v2, p0, Lcom/appbrain/e/r;->d:Lcom/appbrain/c/n;

    invoke-interface {v2}, Lcom/appbrain/c/n;->size()I

    move-result v2

    if-lt v0, v2, :cond_2

    :goto_1
    iget-object v0, p0, Lcom/appbrain/e/r;->e:Lcom/appbrain/c/n;

    invoke-interface {v0}, Lcom/appbrain/c/n;->size()I

    move-result v0

    if-lt v1, v0, :cond_3

    iget v0, p0, Lcom/appbrain/e/r;->b:I

    and-int/lit8 v0, v0, 0x2

    if-ne v0, v3, :cond_1

    const/4 v0, 0x4

    invoke-direct {p0}, Lcom/appbrain/e/r;->h()Lcom/appbrain/c/c;

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By Kayleigh Skinner of The Commercial Appeal

A Memphis man is in jail for allegedly opening fire in an apartment complex and striking multiple people, according to the Memphis Police Department.

Derrick Vaughn, 23, was arrested and charged with seven counts of criminal attempt to wit: first degree murder.

According to an affidavit, an officer was in the 2100 block of Woods Edge Drive near the Bartlett city limit when he heard shots fired in the area just before 7 p.m. May 5.

Officers arrived on the scene and found a male suspect on the ground with a gunshot wound to the abdomen and a pistol near his hand, the affidavit said. He was taken to Regional Medical Center in critical condition.

Seven victims were involved in the shooting; the affidavit did not


Clinical diagnosis and treatment of endodontic and periodontal lesions.
Because of the intimate relationship of the root canal system and the periodontium, developing endodontic and periodontal lesions may mimic each other in clinical and radiographic appearance. The etiology, diagnosis, treatment, and prognosis of endodontic and periodontal lesions will be discussed.Drilling a well in a hydrocarbon bearing subterranean formation for the production of hydrocarbons from the formation typically involves use of a drilling apparatus and drilling fluid. The drilling apparatus usually comprises a bit mounted on a string of hollow steel pipe. This hollow pipe is often used to rotate the bit to enable the bit to cut into the formation. The hollow pipe also acts as a conduit for the drilling fluid to be pumped down to the bottom of the hole, from where it rises to the surface via the annulus between the drill string and the borehole wall. The drilling fluid has many functions, one of the most important of which is to convey the cuttings from the bit downhole up to the surface of


maximal or not will provide a sensitive test of our phenomenological ansatz. We have also established the direct relations between the model parameters and relevant experimental observables. We remark that the democratic neutrino mixing scenario is simple, viable and suggestive. It could be useful for model building, in particular at a high energy scale at which the $\rm S(3)_L \times S(3)_R$ symmetry of charged leptons and the S(3) symmetry of Majorana neutrinos are expected to become relevant.

One of us (Z.Z.X.) is grateful to S. Zhou for useful discussions and partial involvement at the early stage of this work, which was supported in part by the National Natural Science Foundation of China.

[99]{} SNO Collaboration, Q.R. Ahmad [*et al.*]{}, Phys. Rev. Lett. [**87**]{}, 071301 (2001); [**89**]{}, 011301 (2002); [**89**]{}, 011302shows a marked drift toward liberal identity from white Democrats...

...but not among black Democrats.

Only a little over a third of nonwhite Democrats refer to themselves as liberal. It's a reminder that the advantage held by "conservatives" nationally doesn't necessarily translate into political dominance, since a healthy portion of the "moderates" vote heavily Democratic.


Aronian Crashes Out In Kazan

There was high drama in Kazan today as the favourite for the event tumbled out, and another was quite possibly saved by a malfunctioning clock.

Aronian started badly against Grischuk, losing the first rapid game with the white pieces but he hit back immediately to level the scores in game two.

After a draw in the third game, Grischuk upset the odds in game four and broke Armenian hearts as the knocked the world's #3 rated player out of the Candidates.

Grischuk won the last tie-break game to knock out Aronian

Where did it all go wrong? Aronian crashes out of the Candidates

Even greater drama was to come in the other tie-break match, where Kramnik and Radjabov were still inseparable after drawing all four rapid tie-break games. Radjabovfinally broke the deadlock to win the first blitz game, meaning that Kramnik had to win the next game or be eliminated. After 60 moves of the second blitz game a draw seemed on the cards, but then something incredible happened - the electronic clock malfunctioned!

What happens now? Kramnik and Radjabov look to the arbiter for a decision

After a break of several minutes, during which time the problem was resolved, the players sat down again to resume the game and incredibly Kramnik found a way to win and stay in the match!

After this remarkable stroke of serendipity, Kramnik held his nerve to take the next two blitz games to qualify for the semi-finals.

A determined Radjabov on his way to winning the first blitz game

Radjabov resigns and Kramnik saves


the match

[UPDATE: A translation of the post-game press conference by Kramnik and Radjabov is available at the excellent Chess In Translation website. It includes discussion of the malfunctioning clock incident. Thanks to mishanp in the comments!]

The players now have two days rest before the semi-final matches start on Thursday 12 May. Kamsky faces Gelfand, and Grischuk faces Kramnik. Games start at the usual time of 3pm in Kazan (11:00 UTC, 07:00 Eastern).

Live coverage and more is available at the official website, and live video of the playing hall is available here. Look out for announcements of more coverage here at Chess.com!

So we now know that the next challenger for Vishy Anand's world title will either be:

a Brooklynite...

older than Anand...!

a semi-professional poker player

or Kramnik again!

How are your own predictionsligand, an adapter protein, ASC, and the cysteine protease caspase-1, which is a key mediator in innate immune defense ([@b4]). The NLR family encodes 23 members in humans and at least 34 members in mice, and the ALR family encodes 4 members in humans and 13 members in mice. Upon ligand recognition, the sensor associates with ASC, which recruits caspase-1. Activation of caspase-1 leads to the proteolytic cleavage and secretion of the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18, as well as the release of leaderless proteins involved in tissue repair and cytoprotection ([@b5],[@b6]). In addition, caspase-1 activation results in a rapid, pro-inflammatory form of cell death called pyroptosis ([@b7]). Consequently, inflammasome assembly is tightly regulated to prevent aberrant pro-inflammatory response and cell death.

In this review, we highlight new


NAIP2 promotes physical association with NLRC4, resulting in NLRC4 inflammasome activation (*Fig.* [1](#fig01){ref-type="fig"}) ([@b17]). Additionally, a second group demonstrated that murine NAIP1 recognizes the bacterial T3SS needle proteins, MxiH from *Shigella flexneri* and EprI from *E. coli* ([@b26]). Like NAIP2, ligand bound NAIP1 mediates the formation and activation of the NLRC4 inflammasome complex ([@b26]). Bone marrow-derived dendritic cells (BMDCs) are more reactive to recognizing the T3SS needle protein during a *S. flexneri* infection as compared with BMDMs ([@b26]). In a follow-up study, BMDMs were shown to express insufficiently low levels of NAIP1 in the resting state, suggesting cell-type differences in inflammasome regulation ([@b27]).

Although the sole human NAIP (hNAIP) is highly homologous (sharing 68% identity at the amino acid level) to murine NAIP5, initial studies using human U937 macrophagescells ([@b82],[@b83]). Interestingly, *S. typhimurium* Δ*sifA* and *L. pneumophila* Δ*flaA*Δ*sdhA* (a strain that also lacks flagellin and thus fails to trigger the NLRC4 inflammasome) increased cell death in BMDMs that is dependent on caspase-11 ([@b81]). Further *in vivo* studies demonstrated that caspase-11 expression promotes bacterial clearance of *S. typhimurium* Δ*sifA* but not wildtype *S. typhimurium* ([@b81]). These results provide an explanation for why *S. typhimurium* Δ*sifA* is attenuated *in vivo* ([@b82]). Moreover, these results are consistent with caspase-11 either directly or indirectly sensing LPS.

Cell type-specific inflammasome activation and regulation
=========================================================

Inflammasome activity in epithelial defenses
--------------------------------------------

The primary effectors of inflammasome-mediated control of bacterial infections are thought to be immune cells. However, two recent studies have demonstrated that intestinal epithelial cells (iECs) are also an important source of inflammasome-mediated defense against *S.


IL-1β and IL-18, respectively, and releases the cytokines into the extracellular milieu through an uncharacterized mechanism ([@b4]). Consequently, secretion of the pro-inflammatory cytokines is controlled by a two-step mechanism, transcriptional priming followed by posttranscriptional processing.

Type I IFN signaling
--------------------

Host cells respond to the presence of invading pathogens with the production of type I interferons (IFNs) ([@b28]). Type I IFNs (e.g. IFNα and IFNβ) are a family of secreted cytokines that act early in the innate immune response. Although type I IFNs are best known for their ability to elicit an effective antiviral response, they have recently been shown to play an important role in the host response to bacterial infections ([@b28],[@b91]). Importantly, specific inflammasomes can be influenced by the production of type I IFNs (*Fig.* [3](#fig03){ref-type="fig"}).

![Type I IFN regulationinto the extracellular space ([@b129]). Upon ligand recognition by an inflammasome sensor, ASC is rapidly polymerized, forming an ASC speck that is readily visualized by microscopy ([@b130]). When cells die via pyroptosis, their intracellular contents are released into the extracellular space. Interestingly, released ASC specks remain active for an extended period of time where they continue to promote the maturation of IL-1β ([@b129]). Furthermore, naïve macrophages that phagocytose extracellular ASC specks become activated and promote soluble ASC polymerization, lysosomal damage and IL-1β secretion in recipient cells ([@b129]). The ability of cells to transfer ASC aggregates by pyroptosis represents a novel mechanism for cell-to-cell communication. However, the relevance of extracellular ASC during bacterial infection is not yet known.

Cytokine production
-------------------

Cytokines are key mediators of the immune system. The cytokines IL-1β


and IL-18 are produced in response to inflammasome activation and induce a powerful pro-inflammatory response with pleiotropic effects. IL-1β and IL-18 have amino terminal pro-domains that require cleavage by caspase-1 to generate the bioactive form. Upon cleavage, IL-1β and IL-18 are released from the cell through an unidentified mechanism and signal through the receptors IL-1 receptor (IL-1R) and IL-18R, respectively. The IL-1 receptors trigger a MyD88- and TRAF6-dependent signaling pathway that ultimately activates signal transduction pathways such as NF-κB and MAPK resulting in the release of additional pro-inflammatory cytokines, such as TNFα and IL-6 ([@b131]). In addition, IL-18 stimulates IFNγ production from T and NK cells promoting the antimicrobial activity of macrophages by inducing nitric oxide production ([@b132]). IL-1β can also provide protection against infections by activating severalaligned field .f passed to atomic.StoreUint64"
}

type ts struct {
	e  int64
	e2 []int
	f  uint64
}

func typedStructAlignment() {
	var b ts
	atomic.SwapInt64(&b.e, 9)
	atomic.SwapUint64(&b.f, 9) // want "address of non 64-bit aligned field .f passed to atomic.SwapUint64"
}

func aliasAlignment() {
	type (
		mybytea uint8
		mybyteb byte
		mybytec = uint8
		mybyted = byte
	)

	var e struct {
		a    byte
		b    mybytea
		c    mybyteb
		e    mybytec
		f    int64
		g, h uint16
		i    uint64
	}

	atomic.CompareAndSwapInt64(&e.f, 0, 1) // want "address of non 64-bit aligned field .f passed to atomic.CompareAndSwapInt64"
	atomic.CompareAndSwapUint64(&e.i, 1, 2)
}

func stringAlignment() {
	var a struct {
		a uint32
		b string
		c int64
	}
	atomic.AddInt64(&a.c, 10) // want "address of non 64-bit aligned field .c passed to atomic.AddInt64"
}

func sliceAlignment() {
	var s struct {
		a []int32
		b int64
		c uint32
		d uint64
	}

	atomic.LoadInt64(&s.b) // want "address of non 64-bit aligned field .b passed to atomic.LoadInt64"
	atomic.LoadUint64(&s.d)
}

func


$(this);
     var file = e.target.files[0];
     var reader = new FileReader();

   //Part I could not understand starts here
   reader.onload = (function(theFile) {
     return function(e) {
        var image_file = e.target.result
        $('#img_id').attr('src',image_file);
     };
   })(file);
   reader.readAsDataURL(file);
   //Upto here
 });

I think that reader.onload needs to be assigned a plain event handler, so I replaced the entire section marked above to:
    reader.readAsDataURL(file);
    reader.onload = function(e) {
      var image_file = e.target.result;
      //#img_id is the id of an img tag
       $('#img_id').attr('src',image_file)
    };

And it worked as I expected it to work.
QUESTION: What's the original code doing that the above simplified code is missing? I understand that it is a function expression returning a function and then calling it… but for what? There is just too much of the original code copied around under tutorials and what not on it but no good explanation. Please explain. Thanks

A:

Sure.
The function-wrapped function, here serves the specific purpose of remembering which file it was you were looking at.
This might be less of a problem using your exact codebase, but if


the responsibility of college administrations,[11] privacy laws, journalism ethics, and other issues. Television news organizations that aired portions of the killer's multimedia manifesto were criticized by victims' families, Virginia law enforcement officials, and the American Psychiatric Association.[12][13]

Cho had previously been diagnosed with a severe anxiety disorder. During much of his middle school and high school years, he received therapy and special education support. After graduating from high school, Cho enrolled at Virginia Tech. Because of federal privacy laws, Virginia Tech was unaware of Cho's previous diagnosis or the accommodations he had been granted at school. In 2005, Cho was accused of stalking two female students.[14] After an investigation, a Virginia special justice declared Cho mentally ill and ordered him to attend treatment; however, because he was not institutionalized,condition in college untreated.[8]:78[17]:2

The shootings occurred in separate incidents, with the first at West Ambler Johnston Hall, during which Seung-Hui Cho killed two pupils, and the second at Norris Hall, where the other 31 deaths, including that of Cho himself, as well as all the nonlethal injuries, occurred. Cho used two firearms during the attacks: a .22-caliberWalther P22semi-automatic handgun and a 9 mm semi-automatic Glock 19 handgun.[4]

Cho was seen near the entrance to West Ambler Johnston Hall, a co-edresidence hall that housed 895 students,[18] at about 6:47 a.m. EDT.[3]:25[4] Normally, the hall was accessible only to its residents via magnetic key cards before 10:00 a.m.; Cho's student mailbox was in the lobby of the building, so he had a pass card allowing access after 7:30 a.m., but it


into several classrooms. Erin Sheehan, an eyewitness and survivor who had been in room 207, told reporters that the shooter "peeked in twice" earlier in the lesson and that "it was strange that someone at this point in the semester would be lost, looking for a class".[29] At about 9:40 a.m, Cho began shooting.[6]:90 Cho's first attack after entering Norris occurred in an advanced hydrology engineering class taught by Professor G. V. Loganathan in room 206. Cho first shot and killed the professor, then continued firing, killing nine of the thirteen students in the room and injuring two others.[6]:90 Next, Cho went across the hall to room 207, in which instructor Jamie Bishop was teaching German. Cho killed Bishop and four students; six students were wounded.[6]:90 Cho thena voice vote on June 13, 2007. The Senate passed the measure on December 19, 2007. President Bush signed the measure on January 5, 2008.[135] On March 24, 2008, the U.S. Department of Education announced proposed changes in the regulations governing education records under the Family Educational Rights and Privacy Act (FERPA). Certain of the changes address issues raised by the Virginia Tech incident and are intended to clarify for schools the appropriate balance to strike between concerns of individual privacy and public safety.[137]

When the citizenship of the shooter became known, South Koreans expressed shock and a sense of public shame,[138] while the Government of South Korea convened an emergency meeting to consider possible ramifications. A candlelight vigil was held outside the Embassy of the United States, Seoul.


students, which overflowed the campus's McIntire Amphitheatre, to continue to move forward to change the world.[146]

Some schools went beyond this and offered or provided cash donations and other forms of expertise and support, such as housing for officers and additional counseling support for Virginia Tech.[147][148][149] Both inside the U.S. and abroad, the incident caused many universities to re-examine their own campus safety and security procedures as well as their mental health support services.[150][151]

The Construction Industry Institute (CII), a University of Texas-based research institute promoting collaboration between industry and academia, had a relationship with Tech before the tragedy—having sponsored several Virginia Tech-led engineering research projects. CII felt the loss deeply and upon learning of the tragedy, CII members immediately sought to develop a positive response. In just a fewhistory of mental and behavioral problems. Cho's maternal grandfather was quoted in The Daily Mirror referring to Cho as a person who deserved to die with the victims.[89] On Friday, April 20, Cho's family issued a statement of grief and apology, written by his sister, Sun-Kyung Cho, a 2004 graduate of Princeton University who was employed as a contractor for a State Department office. In it, she stated:

He has made the world weep. We are living a nightmare. Our family is so very sorry for my brother's unspeakable actions. It is a terrible tragedy for all of us. We pray for their families and loved ones who are experiencing so much excruciating grief. And we pray for those who were injured and for those whose lives are changed


Blog

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Chequamegon Helmet Cam Video

Here is some footage from my helmet cam from Chequamegon. I got a 16gb sd card, but the battery ran out before the finish. I did a pitiful job of editing it, but figured it’s better to post it badly than not post it at all. It can be seen at Vimeo too.

Steve,
I really enjoyed this video. I have stopped racing for a few weeks to get some stuff in order with a new house and this took me back to what I love about cycling. Can you tell me the name of the artists and tracks fo the music you had in the background?11*i(d).
13*d**3 - 11
Let b(z) = -9*z + 5. Let o(s) be the second derivative of -5*s**3/6 + s**2 + 119*s. Determine 4*b(r) - 7*o(r).
-r + 6
Let f = 8 + -6. Let l be (f + 2)/(-2) - -19. Let r = 9 - 3. Let t(w) = 3*w**3 - 3*w**2 - 6. Let k(b) = -b**3 + b**2 + 2. Determine l*k(d) + r*t(d).
d**3 - d**2 - 2
Let w(h) = -2*h**2 - h + 2. Let k(l) = -l + 1. Let n be 12/3*(-7 - -6). Let t be k(n). Let b(c) = c**2 - 1. Give t*b(d) + 2*w(d).
d**2 - 2*d - 1
Let s(z) = -2*z - 6. Let o(b) = 7*b - 1. Let v(m) be the third derivative of m**4/3 - m**3/3 +


them.
Not sure how or why this is happening but somehow I'm not referencing the OwinContext which be the might cause in the trace returning an Object reference not set to an instance.
I don't even know how to explain things this MVC/Owin/EF/references is slowly making me miss MS Access, Visual Basic and DLL Hell.

A:

There might be some method to all this madness.
After leaving everything alone for the day I thought, "Well, Register and Forgot Password, and Login are working, why don't I just see if I can add a user to role by hand and then see if I can create my own code to add the user at login since I won't be doing much 'assigning user to role' afterwards?")
So thanks to Google and last but notteam explored an alternative to iPS cells based on the use of transcriptional regulatory networks (TRNs), networks of transcription factors and the genes they regulate. Previous research by the team characterized the dynamic regulatory activities of such transcription factors during cellular differentiation from immature cell (monoblast) to developed (monocyte-like) cell using human acute monocytic leukemia cell lines (THP-1). Their findings led them to hypothesize that functional characteristics of the cell-type are maintained by its specific TRN.

Their new paper builds on this hypothesis, establishing a series of new methods for identifying transcription factors (TFs) for the monocyte network, which play a key role in inducing cell-specific functions. Four core TF genes of the monocyte TRN, identified using this approach, were introduced into human fibroblast cells, expression of which activated


Mumbai Indians and Chennai Super Kings will face off in the IPL 2019 Qualifier 1 on Tuesday.

Mumbai Indians (MI) registered convincing victories over Chennai Super Kings (CSK) in both home and away matches of the ongoing Indian Premier League (IPL) 2019. However, the initial success doesn't guarantee Mumbai Indians another win over CSK at their home ground MA Chidambaram Stadium. The two teams will face off in the IPL 2019 Qualifier 1 on Tuesday. The losing team will then take on the winner of the Eliminator, to be played between Delhi Capitals vs SunRisers Hyderabad, in the Qualifier 2 in Visakhapatnam on Friday. CSK were handed a reality check in their last league fixture, though they would bank on home advantage to seal their place in the summitof the missing family or any registration of the vessel in question.

The Coast Guard on Tuesday called off the search for a boat that reportedly sank in rough seas far off the Central California coast, saying nothing more could be done and that the family’s distress calls might have been a hoax.

“We’ve exhausted the possibilities,” Coast Guard Chief Petty Officer Mike Lutz said. The Coast Guard is treating the incident as a rescue, with the possibility the calls came from a trickster.

Coast Guard Executive Officer Noah Hudson in Monterey said it was tough to call off a search, but that if it was a hoax, “it’s unfortunate that we were forced to use so many resources for so much time.”


getter here for when we need it.
 */
__defineGetter__("Application", function() {
  delete this.Application;
  return this.Application = Cc["@mozilla.org/fuel/application;1"]
                              .getService(Ci.fuelIApplication);
});

Components.utils.import('resource://gre/modules/XPCOMUtils.jsm');

/**
 * \brief Some globally useful stuff for the tests
 */
var SB_NS = "http://songbirdnest.com/data/1.0#";
var SB_MEDIAFILEMANAGER = "@songbirdnest.com/Songbird/media-manager/file;1";

var SB_MM_PROP_FOLDER = "media-folder";
var SB_MM_PROP_FMTFILE = "file-format";
var SB_MM_PROP_FMTDIR = "dir-format";

// An array of what our test results should be
var gResultInformation = [
  { originalFileName: "TestFile1.mp3",
    expectedFileName: "1 - Sample.mp3",
    expectedFolder:   "Managed/Songbird/Unit Test Classics",
    expectedAction:   Ci.sbIMediaFileManager.MANAGE_COPY |
               records of 284 patients: 130 premature, 13 heart disease, 30 pulmonary disease, 92 healthy, and 19 others. Over the same period, 3314 healthy 1-month-old infants had undergone echocardiography for health screening. Among the 92 healthy children with systemic-pulmonary collateral arteries, 52 were diagnosed at the health-screening exam. Therefore, we estimate the incidence of unsuspected systemic-pulmonary collateral arteries in healthy 1-month-old infants to be 1.57% (52/3314). We conclude that systemic-pulmonary collateral arteries may be present normally after birth and then gradually disappear. However, if there are certain predisposing factors, they may persist in order to augment pulmonary flow.


-k

pause

Run Miner.exe and answer questions:

Your crypto: 2 (Aeon v7/v8)

Mining pool address (hostname/IP): aeon.herominers.com

Mining pool port: 10651

Your address (with optional .something at the end): YOUR_WALLET_ADDRESS (can be ADDRESS+PAYMENTID or ADDRESS.DIFF or ADDRESS+PAYMENTID.DIFF)

Password (or x if none): YOUR_WORKER_NAME

Monitoring listen port (0 if no JSON/graphic console): 0 Answer other questions regarding your GPU cards and mining will start.

Happy Mining.to be a medic. All SF soldiers are more like trauma surgeons, and there has been 80% increase in survival rate in combat casualties.

This week I am focusing on CAS. Close Air Support. We are doing Helo’s here at Campbell and will go to Utah next week for Fast Movers.

Next we learn how to use the new mini guns. They are not new, but the idea of mounting them on Hummers is. They fire 50 rounds per second. and literally cut things in half when engaged. Rumor has it. Iraqis stopped attacking convoys when they have mini guns on them. I was told, but we know how stories go, that the Iraqis wanted to capture two mini guns that were on a convoy. Story goes they set up


PLGA nanoparticles stabilized with cationic surfactant: safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat.
This study was carried out to formulate poly(lactide-co-glycolide) (PLGA) nanoparticles using a quaternary ammonium salt didodecyl dimethylammonium bromide (DMAB) and checking their utility to deliver paclitaxel by oral route. Particles were prepared by emulsion solvent diffusion evaporation method. DMAB and particles stabilized with it were evaluated by MTT and LDH cytotoxicity assays. Paclitaxel was encapsulated in these nanoparticles and evaluated in a chemical carcinogenesis model in Sprague Dawley rats. MTT and LDH assays showed the surfactant to be safe to in vitro cell cultures at concentrations <33 microM. PLGA nanoparticles prepared using this stabilizer were also found to be non-toxic to cell lines for the duration ofWe will be focusing on Educational programs in the morning but all volunteers are encouraged to attend. This is great information to have!

The morning session will be packed with fun-filled, refresher trainings for volunteers involved with school program offerings and also for those interested in being hiking guides. Please come for lunch even if you will not be at the morning session.

The afternoon session will be split between retail training and our very popular Tipi program which takes volunteers through the process of setting up and taking down a Tipi. Wear appropriate clothing and bring note-taking materials.

We’re hoping to attract the attention of some brand new volunteers to this gathering. Having your expertise available for these newbies to draw on would be so helpful! We hope you’ll make


Hello, using Vb3.8.4pl2. Avchat build 1772, Integration build 1577. Chat is open to limited users while testing these newer builds. I've checked permissions in usergroups. Users are able to access private rooms without having to input a password.

Additionally, still have problems with avatars and custom avatars not showing. I thought upgrading to the builds identified would have fixed this problem, but that's not the case. My settings also still shows build 1618, rather than 1772.UPDATE: The above has been fixed via an old post. So, I still have the permissions issue described in the first paragraph.supposed to be a confession - on top of all of
the known facts, the D.A.,
judge and defense counsel can see this is a false confession i.e. manufactured.An alleged confessor confessing to things that are not
true makes this a false confession in both alleged confessions. Facts such as Anthony being shot in
the head not the stomach, no guns in the
sewer where the alleged confessor said they would be, Fradario and not Montae
being an alleged accomplice
makes this not a true confession but manufactured evidence. According to u.s. law these inconsistencies should have made the judge
throw the case out. This is similar to the Central Park Jogger case where police manufactured
evidence against 6 innocent youth by way
of false evidence and fed information. But the D.A. and judge didn't throw out
Marvin's case


may be taken into consideration. However, when dyes in a group having the same structure are mixed, then it causes a problem in that a black image having a high reflection density is difficult to obtain.
On the other hand, water-soluble black inks must satisfy the absorption characteristics of covering a broad wavelength range, and are therefore problematic in that their solid concentration is apt to increase and they may worsen the jet-out stability of inks.charges pending against her and was sentenced to time already served, on the prosecution's recommendation.  The parties to the June 9th proceeding before Justice Bloustein were Assistant District Attorney Helen Johnson, defendant Nancy Edwards and her attorney Pablo Diaz.  In contrast to the testimony at DuBose's trial that Edwards had not been offered any deal or promise of any kind for her testimony, the prosecutor represented to the court:

27
"MS. JOHNSON: People respectfully recommend acceptance of the offered plea which is offered by defendant to plead guilty to hindering prosecution as misdemeanor under the second count of the indictment to cover the entire indictment.  The facts substantially are these: in the county of the Bronx; on or about May 30, 1970, the defendant Nancy Edwards, did


Johnson, the time was agreed, win, lose or draw.  There would be a plea to misdemeanor acceptable to the district attorney's office.  In light of all that has taken place and in light of all that the Court is informed about, this Court will sentence this defendant to the time already served in this case, as punishment for the crime to which you pleaded guilty.

38
DEFENDANT: Thank you."  (Emphasis supplied).

39
Counsel for the parties then reiterated their positions:

40
"MS. JOHNSON: Pursuant to the agreement we had, prior to the murder trial, that agreement was made between Mr. Goldsmith in charge of the Homicide Bureau, myself, counsel and the Court, we at this time recommend time served.

41
MR. DIAZ: I will stand on the various conferences that we have had."J Med 327:1541-1548 (1992)). Widner et al. (N Engl J Med 327:1556-1563 (1992)) have shown long-term functional improvements in patients with MPTP-induced Parkinsonism that received bilateral implantation of fetal mesencephalic tissue.
While the studies noted above are encouraging, the use of large quantities of aborted fetal tissue for the treatment of disease raises ethical considerations and political obstacles. There are other considerations as well. Fetal CNS tissue is composed of more than one cell type, and thus is not a well-defined source of tissue. In addition, there are serious doubts as to whether an adequate and constant supply of fetal tissue would be available for transplantation. For example, in the treatment of MPTP-induced Parkinsonism (Widner supra) tissue from 6 to 8 fetuses were used for implantation into the brain


at identical states of development and from identical brain regions, it is virtually impossible to generate primary cultures that are identical. Hence, there exists a significant degree of variability from culture to culture.
A second disadvantage of primary cultures is that the tissue must be obtained from fetuses or early post-natal animals. If primary cultures are to be performed on a regular basis, this requires the availability of a large source of starting material. While this is generally not a problem for generating primary cultures from some species (e.g. rodents), it is for others (e.g. primates). Due to the limited supply and ethical concerns, the culturing of primary cells from primates (both human and non-human) is not practical.
Due to the limited proliferative ability of primary neural cells, the generationIETF Trust and the persons identified as the
document authors. All rights reserved.
This document is subject to BCP 78 and the IETF Trust's Legal
Provisions Relating to IETF Documents in effect on the date of
publication of this document (http://trustee.ietf.org/license-info).
Please review these documents carefully, as they describe your rights
and restrictions with respect to this document.
Abstract
This document is intended to be a source of information about the
Russian Federal standard for for electronic digital signature
generation and verification processes GOST R 34.10-2001 [GOST3410],
which is one of the official standards in the
cryptography used in Russian algorithms (GOST algorithms).
Recently, Russian cryptography started to be used in
applications intended to work with the OpenSSL
cryptographic library. Therefore, this document has been created as
information for users of Russian cryptography.
V.Dolmatov Expires May 10, 2010 [Page 1]

1.2. The purpose of GOST R


filtered as they form very close to the desired signal. With constant amplitude modulation methods, spectrum spreading does not occur, and consequently the signal may be amplified by a nonlinear amplifier.
A trunked PMR system, in which different user groups share same radio channels, has strict requirements regarding adjacent channel interference caused by a transmitter. These requirements call for a good linearity in the transmitter of the used radio system.
In a power amplifier, good linearity is only achieved with poor efficiency. However, the efficiency of portable devices should be as high as possible for the operation time to be adequate and in order not to waste battery capacity. Further, at least relatively good efficiency is required of the power amplifiers at base stations to avoid cooling problems. The achievingQ:

Possible ways to embed python matplotlib into my presentation interactively

I need to present my data in various graphs. Usually what I do is to take a screenshot of my graph (I almost exclusively make them with matplotlib) and paste it into my PowerPoint.
Unfortunately my direct superior seems not to be happy with the way I present them. Sometimes he wants certain things in log scale and sometimes he dislike my color palette. The data is all there, but because its an image there's no way I can change that in the meeting.
My superior seems to really care about those things and spend quite a lot of time telling me how to make plots in every single meeting. He (usually) will not comment on my data before I


Q:

Cordova build fails with "Cannot find module lodash/object/assign"

After adding Android to an iOS-only Cordova project, cordova build fails with
Error: Cannot find module 'lodash/object/assign'
I am aware of this question, but there is no xmlbuilder in my plist directory in the globally installed cordova module (/usr/local). So I am unable to try that quick and dirty solution.
The problem persists even after removing Android and re-running cordova build. I'm not aware of having made any changes to the project since last running cordova build except for a tiny change to a js file in www.
Versions: cordova -v: 5.4.1, node -v: v4.2.4, npm -v lodash: 2.14.12 (if that's even the one used here),
cordova plugins list: cordova-hot-code-push-plugin 1.2.5 "Hot Code Push Plugin"
cordova-media-with-compression 2.0.15 "Media With Compression: Alpha Software Edition"
cordova-plugin-customurlscheme 4.1.3 "Custom URL scheme"
cordova-plugin-deviceauthority for his position.
The Casualty Company, a mutual casualty insurance company, was organized pursuant to the provisions of R.S. 17:17-1 et seq.
R.S. 17:18-1 provides that any company organized under that statute, and its stockholders, members and directors shall have all the powers granted and be subject to all the duties and obligations imposed by Title 14, the general corporation act. A policyholder of a mutual casualty insurance company, such as the plaintiff here, is certainly a member of that company.
In Duffy v. Mutual Benefit Life Insurance Co., 272 U.S. 613, at p. 619, 47 S.Ct. 205, at p. 206, 71 L.Ed. 439, at p. 442 (1945), it was stated:
"[Every] member bears a relation to the mutual company analogous to that which a stockholder bears to the joint-stock company


Company and specifically the plaintiff, as a policyholder and a member thereof, under R.S. 17:18-1 are subject to the duties and obligations imposed by N.J.S.A. 14:3-16 of the corporation act. As such a member it must be made to appear in a proceeding brought by him on behalf of the company that he was a member of the company at the time of the transactions of which he complains. From the complaint, the amended complaint, and the deposition of the plaintiff it is clear that such was not the case here.
The reason for the statute and the finding it was declaratory of the pre-existing law, valid and binding, was set forth by Vice-Chancellor Egan in Bookman v. R.J. Reynolds Tobacco Co., 138 N.J. Eq. 312 (Ch. 1946), atNowadays businesses struggle to get new deals, loyal customers, segments in the market and often are confronted with trust issues in finding the right partners.

The fact is that it’s much easier to establish a company, but more difficult to develop the business and create a successful B2B network.

Worldwide number of registered SMEs is more than 200 million , and every year more than 10 million are being established. Companies make a lot of effort and spend huge amounts on resources for market penetration , even though more than 80% of companies fail in the 1st year and only a few are able to survive and become a success story.

In order to deal with this problem companies are constantly looking for new ways of economic effectiveness, new ways to


deals — businesses may place an enquiry (deals), and other users may receive deals in real-time. The enquirer will be able to receive immediate feedback and offers from businesses.

The platform allows to place or accept limited amount of deals in a day to protect from mass registrations and fake deals. As a result, the enquirer will be rewarded, and businesses will receive the deals.

Trading Platform

The trading platform allows users to promote a wide range of products and services through the smart marketing, sell and buy goods & services online with no charges, and start receiving a flow of deals. Users will be able to use self-executing smart contracts on the trading platform. These features will provide various benefits to the users such as secure and transparent transactions.

B2B Network

Theresidents of the city or have plans to move there in the near future.

“These are just preliminary requirements, which are subject to changes based on the public comments we will receive next month,” said an official at the city’s Gender Equality Division, who asked not to be named due to department policy.

The city will accept public comments from Sept. 1 to Oct. 1.

Despite the fact that the certificates are not legally binding, the city said it’s willing to ask hospitals and businesses to cooperate, with the details expected later.

That could help couples who aren’t legally married sign surgical consent forms on behalf of partners who are incapacitated and can’t speak for themselves or rent housing limited to those who are married.

KEYWORDS LGBT, sexuality, marriage, Chiba


massive table and don't care to get the precise number of pages for every record that matches the query.
You can pass in the option like so:
Model.paginate(:page => params[:page], :per_page => 30, :total_entries => 100)

Intracerebral injection of CpG oligonucleotide for patients with de novo glioblastoma-A phase II multicentric, randomised study.
Immunostimulating oligodeoxynucleotides containing unmethylated cytosine-guanosine motifs (CpG-ODN) have shown a promising efficacy in several cancer models when injected locally. A previous phase II study of CpG-ODN in patients with recurrent glioblastoma (GBM) has suggested some activity and has shown a limited toxicity. This multicentre single-blinded randomised phase II trial was designed to study the efficacy of a local treatment by CpG-ODN in patients with de novo glioblastomas. Patients with a newly diagnosed glioblastoma underwent large surgical resection and CpG-ODN was randomly administrated locally around the surgical cavity. The patients were then treated according to standard of care (SOC) with radiotherapy and temozolomide. The primary objective was 2-year survival. Secondary outcomes were progression free


everyone on our bus was very grateful for.

We arrived in Pai with intentions of doing the full Mae Hong Son loop but it quickly became apparent we wouldn’t be leaving Pai in a hurry. Originally we planned to spend just 2 days in Pai but somehow this turned into 6 and plans of trying to fit in the rest of the loop were quickly abandoned.

Pai itself is a chill little village with a hint of a hippie vibe. It has become a haven for backpackers in northern Thailand. Whilst it was once probably an exotic destination off the beaten track offering a unique insight into village life, the Pai of today has definitely been discovered.

This has both positives and negatives, on the negative side Pai is now gearedwas disgusted for about 1 minute, but as I’d stupidly worn my thongs I quickly embraced those handrails, bat crap and all. Make sure you bring some hand sanitiser with you because I guarantee you’ll be gripping those hand rails too! Once you get to the end of the first cavern you’ll jump on a bamboo raft for a few mins to cross to the end of the cave, you’ll get out here and go up yet more stairs to another cavern before coming back down and beginning the walk back to the park entrance.

the entrance to the caves

Pai Canyon

We stopped by Pai Canyon for sunset…but so did basically every other tourist in Northern Thailand, for a more serene experience try going for sunrise. Regardless of when you


impressive views, great coffee and even better a verandah full of swing chairs! We got caught here during a storm and ended up staying for a few hours, the staff were super chill and even has some decent tunes playing, all in all I can think of worse places to be stuck.

Since we live on the beach back home we’d decided that instead of heading south to the resorts Thailand is famous for we’d go a different route and from Bangkok head North to Chiang Mai. It’s a fair way between these two cities and since we’re trying to work with a budget, we decided to go overland and break the trip up with a few stops along the way. Enter Ayutthaya, Sukhothai and some pretty cool ancientUNC

For More Information

Predicting autism: Study links infant brain connections to diagnoses at age two

UNC news release

Reference

Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Emerson RW, Adams C, Nishino T, Hazlett HC, Wolff JJ, Zwaigenbaum L, Constantino JN, Shen MD, Swanson MR, Elison JT, Kandala S, Estes AM, Botteron KN, Collins L, Dager SR, Evans AC, Gerig G, Gu H, McKinstry RC, Paterson S, Schultz RT, Styner M; IBIS Network, Schlaggar BL, Pruett JR Jr, Piven J. Sci Transl Med. 2017 Jun 7;9(393). pii: eaag2882. doi: 10.1126/scitranslmed.aag2882. PMID:28592562

###

About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): The NICHD sponsors research on development, before and after birth; maternal, child, and family health; reproductive biology and population issues;


and medical rehabilitation. For more information, visit the NICHD website.

About the National Institute of Mental Health (NIMH): The mission of the NIMH is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery and cure. For more information, visit the NIMH website.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit the NIH website.

NIH…Turning Discovery Into Health®

when you look in the mirror, and your mind is telling you all the things you’re not, if those things are, you’re not cool enough, you’re not pretty enough, you’re not successful enough, you’re not special, you’re not wanted, you’re not unique, these are not the things you are not. Let me tell you the things you are not. You are not somebody else’s opinion of you, that’s what you’re not.” - Taylor Swift

🎥 (outtakes) I LOVE to have fun on my sets! You better come ready to laugh, cut up, and work! 🎬 Should out to @janabthompkins she brought it hard! But she ain’t have to do @cloud.zion like that though! You know he going to cry in the car! 😂😂😩🙌🏾 • @sarpyperspective

when a person is in


1. Introduction {#sec1-nutrients-10-01106}
===============

Bread is a staple food in many countries around the world and is one of the key products within the cereal and cereal products group of foods. It is a useful food vehicle for fortification of at-risk micronutrients in the Australian diet, specifically serving as a strategy to help reduce the incidence of Wernicke-Korsakoff syndrome \[[@B1-nutrients-10-01106]\] (via thiamin) and improve folate \[[@B2-nutrients-10-01106]\] and iodine status \[[@B3-nutrients-10-01106],[@B4-nutrients-10-01106]\]. The National Nutrition and Physical Activity Survey (NNPAS), as part of the Australian Health Survey 2011--2013 \[[@B5-nutrients-10-01106]\], identified that within the bread category, plain, regular bread and bread rolls are consumed by 66% of Australians with a median consumption of 72 g (approximately two average slices) on the day prior to the NNPAS interview \[[@B5-nutrients-10-01106]\]. Most often, this was white# this caused some trouble because not all subarrays were size 5
                            # index which is 2.
  return chunks

def Select(A, k):

  if (len(A) == 1):  # if the array is size 1 then just return the one and only element
    return A[0]
  elif (len(A) <= 5): # if length is 5 or less, sort it and return the kth smallest element
    insertion_sort(A)
    return A[k-1]
  else:
    M = get_chunks(A, 5)  # this will give you the array of medians,,, don't sort it....WHY ???


 # now try the same thing with promoted var
        root = Group()

        P = root.add('P', IndepVarComp('x', np.array([1., 2., 3., 4., 5.])))
        G = root.add('G', Group())
        C = root.add('C', SimpleComp())

        A  = G.add('A', SimpleArrayComp(), promotes=['x', 'y'])
        G2 = G.add('G2', Group())

        A2 = G2.add('A2', SimpleArrayComp(), promotes=['x', 'y'])

        root.connect('P.x', 'G.x', src_indices=[0,1])
        root.connect('P.x', 'C.x', src_indices=[2,])
        root.connect('P.x', 'G.G2.x', src_indices=[3, 4])

    class StaticBCast(Component):
            def __init__(self, num_nodes):
                super(StaticBCast, self).__init__()
                for name in param_arg_names:
                    self.add_param('P_s:{0}'.format(name), 0.)

            def solve_nonlinear(self, params, unknowns, resids):
                pass

        class StateInterp(Component):


2011 Ykkönen

The Ykkönen 2011 season began on 28 April 2011 and ended on 22 October 2011.

The winner team will qualify directly for promotion to Veikkausliiga 2012. The bottom 4 teams will qualify directly for relegation to Kakkonen.

Overview

A total of thirteen teams will contest in the league, including ten sides from the 2010 season, FC Lahti who was relegated from Veikkausliiga, AC Oulu who was refused a license for Veikkausliiga and HIFK who promoted from Kakkonen after winning the promotion play-offs.

Managerial changes

League table

Results

Statistics
Updated to games played on 22 October 2011.

Top scorers
Source: soccerway.com

References

External links
 Official site

Category:Ykkönen seasons
Category:2011 in Finnish football leagues
Fin
Finfeature.

As Wilms opened up the YouTube app, the screen behind him projected the live-streaming function. In terms of its UI, the design matches Periscope, in that it shows you live interactions in the form of speech bubbles that mount up on the left-hand side of the display. Other live-streaming icons include a viewer count, a “like” count, and a button that lets you switch between the front and rear cameras on your smartphone. As Wilms demonstrated, you can also take a photo beforehand as a title banner for your broadcast.

“I’m really looking forward to seeing how everybody here uses these creative tools,” Wojcicki said during the keynote. The live-streaming capability is currently exclusively available to a small selection of YouTube’s biggest creators, including The Young Turks, AIB, and


to find all work done in Alabama or any work that used the National Assessment of Educational Progress (for example).

New Author Identification Numbers

The third new field adds links to author’s biosketch pages. It can get confusing when several authors have the same name, and when the same author can publishes under different names. For example, the same individual could publish under “John Young,” “John P. Young,” “J.P. Young,” and “Jack Young.” ERIC does not have the ability to determine if these are all the same people, but we were able to add hyperlinks to those authors that have an Orchid ID or a SciENcv page set up. If these numbers are available when we are indexing the record, we will be able to link to authors’ pages soErson XL Xtreme Load Bushed Roller Lifters - $899

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Never again have Catastrophic Lifter Failure from needle bearing failure contaminate your entire engine.


in patients with obesity and LBP.

The aim of our study was therefore to quantify the gait pattern of obese subjects with and without LBP and normal-mass controls by using GA, in order to investigate the combined effects of obesity and LBP on gait.

Materials and methods
=====================

Participants
------------

We included in the study 8 obese females (BMI ≥ 35 Kg/m^2^) with chronic LBP (OLG group). According to the Italian Guidelines on LBP \[[@B30]\], chronic LBP was defined as lumbar pain with no evidence of specific origin lasting more than 3 months. Our subjects had a chronic non-specific pain and were not under any medication at the time of the experiment. We excluded subjects with secondary LBP, sciatica, osteoporosis, osteoarthritis, rheumatologic, metabolic or hematologic abnormality with potential to affect lower limb function andobese subjects with LBP.

Conclusions
===========

In conclusion, this study shows a different motor strategy during gait among OLG, OG and CG. From a clinical point of view, our results suggest that rehabilitation program should include specific treatments to improve gait pattern in obese patients with and without LBP. Parallel to weight loss, gait retraining and selective muscle strengthening with attention to ankle, hip and pelvis strategies appears therefore crucial to prevent possible musculoskeletal disorders, improve the gait pattern and the ability to sustain this key aerobic activity for managing mass reduction programs.

Competing interests
===================

The authors declare that they have no competing interests.

Authors\' contributions
=======================

All authors read and approved the final manuscript

VC made substantial contributions to analysis and interpretation of data and was involved in drafting the manuscript

LV made substantial contributions to data


"[keyword <:]", "[keyword <:>]"
  );

  MT("within an attribute list, mscgen/ xù attributes classify as base",
    "[base [[label]",
    "[base idurl id url]",
    "[base linecolor linecolour textcolor textcolour textbgcolor textbgcolour]",
    "[base arclinecolor arclinecolour arctextcolor arctextcolour arctextbgcolor arctextbgcolour]",
    "[base arcskip]]]"
  );

  MT("outside an attribute list, mscgen/ xù attributes classify as base",
    "[base label]",
    "[base idurl id url]",
    "[base linecolor linecolour textcolor textcolour textbgcolor textbgcolour]",
    "[base arclinecolor arclinecolour arctextcolor arctextcolour arctextbgcolor arctextbgcolour]",
    "[base arcskip]"
  );

  MT("a typical program",
    "[comment # typical msgenny program]",
    "[keyword wordwraparcs][operator =][variable true][base , ][keyword hscale][operatorproperty and human body. Now, in the modern world, capital offences further covered drug-trafficking, hijacking the airplanes, bribery etc. Some Muslim countries like Saudi Arabia even want to add artificial insemination also to the list of capital offences.

Retentionists of Capital Punishment argue that Capital Punishment is necessary to maintain peace in the world since it acts as a deterrent to potential offenders. In the beginning, public opinion was also in favor of Capital Punishment in preference to life imprisonment. On the other hand abolitionists argue that Capital Punishment failed as a deterrent and no major work of any researcher ever proved its efficacy. Further they maintain that it is an inhuman punishment arbitrarily imposed on the poor, the minority, the uneducated and the downtrodden. The conflict of opinion


his ability to continue to throw strikes and really attack the strike zone. Like all pitchers, he’s going to give up a few hits, but he did not back off.”

It will be the long haul that shows exactly what the Mariners have from their new man from Japan. He’s already learned to adjust to the slicker balls that MLB uses as well as to the different workouts and training methods, which are far different from Japan.

“Yusei is a learner,” Servais said. “That’s how he’s wired. He wants to learn the Major League game as quickly as he can. The questions he’s asked show he’s very diligent in his work and wants to come up with a routine as quickly as he can to adjust to our game anddoing so, Wallboard asserts that because respondents are not "unsophisticated businesses," they could have and should have protected themselves in other ways. Although Wallboard correctly states that one purpose of the prelien-notice requirement is to protect homeowners and small businesses from having to pay twice for the same work, such a purpose does not allow the courts to ignore, or loosely apply, explicit statutory requirements to accomplish that purpose. In fact, we have stated that examining the sophistication of owners likely hinders the achievement of the statutory purpose. See Emison, 488 N.W.2d at 338 ("If the courts began evaluating the relative sophistication of owners, it could eliminate the protection of the prelien notice requirement the legislature has granted to homeowners."); see also Dolder, 323 N.W.2d at 780 ("To


beach in San Francisco when people spelled out "RESIST!!" on the sand.

“The ‘March 4 Impeachment’ is just one of thousands of events to promote the efforts to resist the Trump agenda. We resist his misogynistic, xenophobic, and climate denial policies to name a few,” organizers of this rally said in a press release.the action which he desires the court to take or his objection to the action of the court and his grounds therefor * * *"

5
 Cf. also General Accident Fire & Life Assurance Corp. v. Zapel, 5 Cir., 1956, 231 F.2d 917, 921, footnote 4; Popejoy v. Martin, 5 Cir., 1955, 227 F.2d 199; Fort Worth and Denver Railway Company v. Harris, 5 Cir., 1956, 230 F.2d 680, 682; American Fidelity & Casualty Co. v. Drexler, 5 Cir., 220 F.2d 930, 934; and Employers Mutual Casualty Co. v. Johnson, 5 Cir., 1953, 201 F.2d 153, where we applied the rule to a case arising in Texas
And see, as establishing the same rule under Texas decisions, Dabney v. Keene, 1946, Tex.Civ.App., 195 S.W.2d 682, 684; Seymour v. Texas &


if the fill you create uses smooth pixels or more jagged pixels. * Contiguous will create your fill based on the similarity of pixel shade in color. * The All Layers option will allow you to make fills based on how many layers your image has. You can use this tool for all kinds of reasons as it can have use for both practical and design purposes. Feel free to experiment. Read more by visiting our page at: http://www.mahalo.com/learn-adobe-photoshop-paint-bucket-tool/between windows of the current program.

------
xeno42
If you've used Cmd-C to copy something to the clipboard, pbpaste is really
useful to pipe the clipboard contents into a pipe or to a file (pbcopy being
the inverse)

------
jonbaer
Shift+Cmd+4 for screenshot(s)

~~~
vtrips
Shift + Cmd + Ctrl + 4 for copying the screenshot into clipboard

~~~
jzl
OMG. This is awesome. I always open the "Grab" program but this is exactly
what I should have always known. Thank you!

------
Oldham-Made
Setting a text replacement (sys-prefs > keyboard > text) for "@@" to your
email address. It's something we type multiple times a day, it's important to
not have a typo, and @@ is something you rarely type in any context. This
works with most apps, though some won't allow the text replacement to apply.

------
cheyne_nz
Cmd up arrow and cmd down arrow for navigating through folders and


the current
app.

This IS pretty much the built-in command palette for all apps!

------
kristjansson
Command-<down arrow> to open the selected item in finder. A small convenience,
but makes my finder usage completely mouse free.

------
spiffytech
The Contexts app makes Cmd-Tab behave like it does in Windows, switching
between windows, and only ones on the current Space.

------
seanwilson
Not a shortcut exactly, but turn on the "zoom" accessibility feature bound to
something like CMD. You can then zoom in anywhere on the screen by holding the
shortcut and doing a two finger gesture. Useful for reading small text,
checking some CSS rendering close up and to point out a feature on the screen
to someone nearby.

------
xeno42
Ctrl-Cmd-Space in most text edit fields to open the character viewer to enter
emoji and other common unicode characters

------
cimnine
Ctrl+Shift+Eject/Power: Turn off the screen; Cmd+Alt/Option+Eject/Power: Send
macOS to sleep

------
cygned
⌘^q tolock the screen

~~~
sethammons
that quits my active window. I have to cmd+ctrl+q

~~~
cygned
^ is the symbol for ctrl, sorry for the inconvenience

~~~
sethammons
doh, my bad!

------
vinhnx
macOS:

* command+O: open file

* command+shift+3/4/5: screenshot tool (one of the best shortcut on macOS in my opinion)

* command+alt+space: switch keyboard input source

* "=", ">", "<" "-", while holding down `option` gives you "≠", "≥", "≤", "–"

Apps:

\+ Safari: command+shit+\ (show tab overview)

\+ FileMerge: command+D to jump to next conflict

\+ VSCode: control+shift+E: toggle focus

\+ iTerm2: command+] to switch between panes

\+ iTerm2: command+K: clear buffer

\+ Dash: command+shift+D

\+ Spectacle: [https://github.com/eczarny/spectacle#keyboard-
shortcuts](https://github.com/eczarny/spectacle#keyboard-shortcuts). And also,
as zuccs's comment
[https://news.ycombinator.com/item?id=20621517](https://news.ycombinator.com/item?id=20621517)

~~~
gt2
\+ VSCode: CMD + b toggles the sidebar (whichever is open)

------
source99
The app witch lets you command-tab to switch apps but it lets you choose any
open window of any app. So if you have 4 separate terminals and 3


The oft controversial animal-rights group PETA has beef with the ostensibly animal-friendly Impossible Burger.

PETA, short for People for the Ethical Treatment of Animals, is fired up over the fact that the vegetarian burger’s maker, Impossible Foods, tested the safety of its faux patty on animals. Impossible Foods has openly noted that it conducted animal experiments—involving a total of 188 rats—to convince the Food and Drug Administration that the burger’s key, blood-like ingredient qualified as a safe food additive. The company was after a controversial FDA designation called “generally recognized as safe” or GRAS. The animals were sacrificed after the testing.

In a blistering blog post, PETA claimed the testing was “voluntary” and that Impossible Foods conducted the test after “disregarding advice from a PETA scientist who said that there’sgroup noted:

Impossible Foods’ big claim to fame is that there’s heme in its burgers. Well, here’s a shocker: This heme comes from soy leghemoglobin and contains more iron than that found in the heme of a similar serving of red meat. Having too much iron in your blood can mean a greater risk of developing cancer, especially for men and postmenopausal women.

Researchers have indeed linked excessive iron (aka iron overloads) to risks of cancer. But it seems rather implausible to achieve such levels by simply eating an Impossible Burger, or a hundred. For one thing, healthy people typically don't accumulate excessive levels of iron. As the National Institutes of Health’s Office of Dietary Supplements notes, “Adults with normal intestinal function have very little risk of iron overload from


can claim someone else’s royalties? And yes, legally. In order to raise money during an estate sale (of a deceased artist), heirs to the deceased artists sometimes auction part or all of the percentage of the deceased artist’s song to raise money. Indeed, some auctions are even by living artists seeking to raise funds if they need the money. Keep an eye out for royalty auctions, as once you get a percentage of ownership of the song, you will be entitled to a steady pay check until the copyright expires on the song. In the meantime, you can then start working on your next royalty producing gem!$$(Q)_{ij} =
\begin{cases}
d_i &\text{~if~} i=j \\
-1 &\text{~if~} (i,j)\in\mathcal{L} \\
0 &\text{~otherwise},
\end{cases}$$ where the degree $d_i$ is equal to the number of nodes adjacent to node $i$. In the case of weighted graphs, each link $(i,j)\in\mathcal{L}$ also has an associated weight $w_{ij}>0$ and the degree is equal to the sum of all incident link weights. An unweighted graph is thus a special case of a weighted graph with all link weights equal to $w_{ij}=1$. The pseudoinverse $Q^{\dagger}$ of the Laplacian matrix $Q$ is defined by the relations [@krl_bestspreader] $$QQ^{\dagger}=Q^{\dagger}Q = I-\frac{uu^T}{N},$$ where $u=(1,1,\dots,1)^T$ is the all-one vector. As suggested by its name, the *pseudoinverse Laplacian* $Q^{\dagger}$ is the inverse of the Laplacian matrix in the space orthogonal to $u$. In other words, the expression $Qx=y$ can be inverted to $Q^{\dagger}y=x$