Rumor – In-game XMB coming in June

I really do feel bad for PS3 users. They’ve been getting a little more love over the last year or so with lower prices and a larger library of games. However, they still have no in-game XMB. Rumors are once again floating around that this long-desired feature will soon be making its way onto consoles everywhere.

According to rumor, the PS3 will be reciving a new firmware update of v2.40 sometime in June, which will in fact include in-game XMB. Features like a universal friends list and in-game messaging will supposedly all be there.

We’ve heard plenty of rumors before, but this one claims to be totally real and 100% legit, so I feel confident in saying that I’ll believe it when I seeworkers occurs on-chain

Workers provide computational power to the system

Verifiers are staked entities that issue tasks and verify results

Off-chain protocol between Verifiers and Workers for execution results, receipts, histories, and blockchain payments.

Probabilistic Payment Model that allows for trustless, stateless payments that scale with number of tasks.

Trustless Verifiable Computing

The objective is trusted computing. We have a job provider j, and we have a worker w, with computation c(a, b). j wishes to incentivize w to perform c(a, b). w is assumed malicious. w could perform zero calculation and provide output . j has no way to verify the validity of . j rewards w.

Strategy One, j gives computation c(a, b) to w1, w2, w3, … wn. In order mentioned they provide , , , , j can assume is correct.


be American health policy," said Greg Vigdor, president and CEO of the Arizona Hospital and Healthcare Association.

Concern over pre-existing conditions

Arizonans protest at U.S. Sen. Jeff Flake's office A group of Arizonans marched into U.S. Sen. Jeff Flake's office at 10:40 a.m. and told staff working there to call Flake right away and have him give his position on the American Health Care Act. Sean Na/azcentral.com

Meanwhile, other health-care groups have held meetings, rallies and other events to highlight their concerns about the bill.

On Monday, Phoenix Mayor Greg Stanton joined a coalition of organizations representing seniors, children and low-income families at a conference in Phoenix explaining how an Affordable Care Act replacement could affect different groups.

One of the speakers, Sergio Rodriguez, 34, said he worries that the GOP Senate billon the World Wide Web with this type of healing relaxation music.

If you have sleep problems during the night, try listening to relaxation music that is aimed specifically to assist with sleep issues. Light some incense or use aromatherapy to compliment the music. (Please remember to never to use a naked flame unattended!) The combination of healing relaxation music and aromatherapy (lavender is great to help you to sleep – a few drops on your pillow works wonders), will have you sleeping in no time at all.

It has even been proven by scientific research that relaxation music can assist with the acceleration of recovery from an illness or particular injury. This is not just a placebo effect that we are speaking of here, this has been proven time


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Advanced training to stop eye problems in their tracks

Three new advanced nurse practitioners are joining the ophthalmology team at Kidderminster Hospital and Treatment Centre to help meet growing demand for sight-saving treatment.

The nurses have been trained up following a growing increase in the number of patients needing monthly injections to ward off age-related macular degeneration (AMD).

Nurse  $total_bids = mysqli_stmt_num_rows($stmt_1);
    mysqli_stmt_close($stmt_1);
}

// show all jobs with total bids
...

 }

$stmt0->close();

How can I do this with one query?

A:

You could use a Join a count and  group by
     SELECT a.jobId,a.userid, a.title, count(b.jobid) as bidsTotal
     FROM jobs as a
     inner join bids as b on b.jobId = a.JobId
     WHERE userid=?
     Group by  a.jobId,a.userid, a.title


Q:

Expected Value of Matches Played Between Two Teams

Two athletic teams play a series of games; the first team to win $4$ games is declared the overall winner. Each team has a probability of $.5$ of winning each game. What is the expected number of games played?

My question is what is the best way to solve this problem?
I guess I could approach it like:
$P(X = 4) = 2(.5)^{4}$ (two shots of $1$ team winning $4$ straight)
and enumerating each possibility from $X=4$ to $X=7$, then solving for $E[X]$, but what about large values of this problem like first to $50$ wins or something?

A:

A general strategy is to compute the expected number of games $t(xy)$ played until a team is declared the winner, starting from every possible partial score of $x$either version 2 of that License or (at your option) any later version.
 *
 */

#include <linux/kernel.h>
#include <linux/interrupt.h>
#include <linux/device.h>
#include <linux/delay.h>
#include <linux/slab.h>
#include <linux/termios.h>
#include <linux/debugfs.h>

#include <mach/sdio_al.h>
#include <mach/sdio_cmux.h>
#include "u_serial.h"

#define SDIO_RX_QUEUE_SIZE		8
#define SDIO_RX_BUF_SIZE		2048

#define SDIO_TX_QUEUE_SIZE		8
#define SDIO_TX_BUF_SIZE		2048

/* 1 - DUN, 2-NMEA/GPS */
#define SDIO_N_PORTS	2
static struct sdio_portmaster {
	struct mutex lock;
	struct gsdio_port *port;
	struct platform_driver gsdio_ch;
} sdio_ports[SDIO_N_PORTS];
static unsigned n_sdio_ports;

struct sdio_port_info {
	/* data channel info */
	char *data_ch_name;
	struct sdio_channel *ch;

	/* control channel info */
	int ctrl_ch_id;
};

struct sdio_port_info sport_info[SDIO_N_PORTS] = {
	{
		.data_ch_name = "SDIO_DUN",
		.ctrl_ch_id = 9,
	},
	{
		.data_ch_name = "SDIO_NMEA",
		.ctrl_ch_id = 10,
	},
};

static struct workqueue_struct *gsdio_wq;

struct gsdio_port {
	unsigned			port_num;
	spinlock_t			port_lock;

	unsigned			n_read;
	struct list_head		read_pool;
	struct list_head		read_queue;
	struct work_struct		push;
	unsigned long			rp_len;
	unsigned long			rq_len;

	struct list_head		write_pool;
	struct work_struct		pull;
	unsigned long			wp_len;

	struct work_struct		notify_modem;

	struct gserial			*port_usb;
	struct usb_cdc_line_coding	line_coding;

	int				sdio_open;
	int				sdio_probe;
	int				ctrl_ch_err;
	struct sdio_port_info		*sport_info;
	struct delayed_work		sdio_open_work;

#define SDIO_ACM_CTRL_RI		(1 << 3)
#define SDIO_ACM_CTRL_DSR		(1 << 1)
#define SDIO_ACM_CTRL_DCD		(1 << 0)
	int				cbits_to_laptop;

#define SDIO_ACM_CTRL_RTS	(1 << 1)	/* unused with full duplex */
#define SDIO_ACM_CTRL_DTR	(1 << 0)	/* host is ready for data r/w */
	int				cbits_to_modem;

	/* pkt logging */
	unsigned long			nbytes_tolaptop;
	unsigned long			nbytes_tomodem;
};

void gsdio_free_req(struct usb_ep *ep, struct usb_request


sound as a Tamil name." "You are right!" "My original name is Kuppan!" "Oh gosh!" "They called me Banner Kuppan because I used to stick cinema banners." "I felt uneasy." "So, like Sivajee, Nehrujee, and Nethajee.." "I took the jee from that and joined with banner." "My name is Banerjee since then." "Banerjee is very famous name in Kolkata." "I am very famous all over the world." "One more." "Why are you asking?" "Henceforth I have to order." "Jiggiri.." "Dhooth(milk)!" "Jiggiridantha dhooth(Spicy milk)!" "You've drunk so fast, haven't you?" "Jiggiridantha is very tasty." "I feel like floating." "Is it?" "Why is he taking away the shop?" "He is taking away his shop." "Isn't it?" "Bye!" "Why are they saying bye?" "Cricket match is going on." "Is it?" "Haven'tcontinue." "She has come like this with phone in her hand.." "..and she looked like a killer to my eyes with the gun in his hand." "Then, continue.." "He put this cloth on me like this.." "Stop!" "I thought that the murderer will be strong, if visible." "That's why.." "Go ahead." "Then, he has hugged me.." "I didn't hug her.." "I tried to hug the killer but I hugged her.." "Go ahead." "And we fought each other by rolling down from the upstairs." "Then..?" "I realised that the gun was a phone.." "..and the criminal as her after switching on the light." "Fine!" "Why have you called at midnight 1 2'o clock?" "You are a matured girl too.." "I told you that you shouldn't use the phone often,


happily." "No return." "Don't cry." "police!" "if I leave it, I won't get another chance." "There was an accident on the way." "No problem." "They have made all arrangements correctly." "You would have gone, if I had come a Iittle late." "Now too." "Why are you standing here?" "Go inside." "Thank God!" "He asked you to go inside the bus." "Are you also going with them?" "You are there now too.." "I forgot water can." "Go, bring it." "I'lI bring it." "Security!" "Come here." "Have you checked the vehicle thoroughly?" "I've checked the vehicle thoroughly in the morning." "Bombs are being blasted because people like him are there." "What?" "He is the commissioner." "I know." "That's why I am calling him." "Come sir." "Where do you call me"I've tried very much to save you." "We thought that you are unconscious.." "..but finally you've gone mad." "What are you blabbering dear?" "We are not blabbering but you" "it's better, that he gained consciousness." "Unconscious?" "You have been unconscious since morning." "Didn't I die in the explosion?" "Will anyone die in a tyre blast?" "Did the tyre blast off?" "Isn't it the heaven then?" "No, it is DarjeeIing." "Get up." "Oops!" "Sir car has come." "Go away." "Gosh!" "uncle has come." "Run away." "Fine!" "What happened to the bomb?" "I removed the bomb while changing the tyre." "Why dear?" "I was in the bus." "That's why." "I've to be alive to achieve a lot." "Henceforth it won't get blasted, will it?" "No one knows when and how


on both the Murugan!" "Oh!" "Don't see that." "It was taken when my uncle was bathing." "No problem, we'Il see." "Tell them I was naked in that" "He was naked in that." "Disgusting!" "Give me." "I'll see that." "Haven't you seen a man before?" "I have seen a man bathing, but I didn't see you bathing." "Why do you see that in this?" "Come aside." "I'lI show you live." "No." "After that I could neither sleep nor play music." "if you play music, can you become Harris Jayaraj in one day?" "Get lost!" "I am calling you only." "Me." "Why do you show respect to me?" "Ok." "In our childhood, we used to bet when we played marbles.." "Do you remember that?" "Yes, how can I forget it?"kill him again.." "..I would finish your man." "You won't finish him." "Won't you allow us to finish him?" "Have you forgotten about the crores you received?" "I didn't get that." "Have you separated us?" "Ok, you didn't get that." "Then, get off." "We will finish him." "I won't allow you to do that." "To whom are you talking?" "Have you forgotten that you are talking to dad?" "You are alive as I had that in my mind." "Why are you talking about father to him?" "He has killed his own father." " He would speak like that." "No!" "I am still talking because no one should kill my father." "Is he your father?" "Now, I am telling." "I am telling you, this finally." "Get out from this


with dew drops." "Enjoy it!" "Is there any gap between us?" "You open your eyes in the night!" "My days are like midnight!" "It is a new taste!" "Is it honey to caper?" " My dream.. my dream.." "will you be mine hereafter?" "Did you keep everything in your mind what I have taught you?" "Could I forget it?" "My life is only in that." "I cannot forget it." "Come on boys." "Bring him to the upstairs." "What would you say?" "Tell me." "There is a person called Aadhavan.." "I will tell about him, identify in the person." "He has tied me up in a room.." "He has threatened my poor uncle Benarjee with his pistol.." "..and he has disguised like me and went to judge's house." "Why"Thara, don't do it." "Come!" "Bring it." "Is everything in this, that what I have asked?" "Yes, everything is in this." "Go!" "Come!" "He will die." "Go and start the vehicle." "Get inside." "Fast!" "What are you saying?" "Are you playing?" "I have lost my hand and leg." "How could I play with this?" "Judge too?" "Yes, sir!" "Yes, sir!" "Not only the laptop.." "..-and also the pen drive." "Is it white ambassador?" "Yes, sir!" "Are you sure that no one around you know Tamil?" "Yes, sir!" "Here, all are Bengalis." "I am the only tamil." "I have heard everything and have come here." "Sir, Aadhavan is.." "Why have you come here?" "I am a higher official than you.." "Did you inform me?" "He has called to someone.."


proponent of having fun at the table. Thus, I knew I had to do something if I was going to allow this plan to have a chance of working.

That’s where divine intervention plays a part.

I only use divine intervention when the fate of the campaign and the players fun is at stake, and I never use it to give the players an assured victory or success. That would take away all of the suspense and the drama of the adventure. So far in my DMing career, I’ve only had to do it twice, and both times it was necessary.

I’m advising that you do the same. If the fate of your campaign and your player’s fun is at stake, I’d interfere with some grand deus ex machina. Again, docompletely depends on your DMing style. Do you think the story will benefit by the party losing this battle? Do you have a contingency plan? Will all the PCs die here, and is everyone okay with that? What if you want the battle to continue, to give your party another chance? Then simply fudge the dice.

What if a terrifying red dragon is breathing fiery hell upon the PCs, a few of them are low on hit points, and you roll near max damage? You know this amount of damage will cause ¾ of your group to go unconscious. What do you do? This completely depends on your DMing style. Do you think the story will benefit by the party losing this battle? Do you have a contingency plan?


A San Mateo-based developer has submitted an application to build a 180-foot-tall mixed-use high-rise in downtown Berkeley over a redesigned Walgreens store.

Shattuck Terrace Green Apartments at 2190 Shattuck Ave., just north of Allston Way, is set to include 274 units, 12,000 square feet of commercial space, and a 19,000-square-foot underground garage with spots for more than 80 vehicles. The 18-story structure would replace a 2-story retail building. Walgreens is there now, and is expected to return if Terrace Green is built, according to project documents.

Read more about tall buildings proposed in Berkeley in past Berkeleyside coverage.

The city’s Downtown Area Plan, which was adopted in 2012 after Berkeley voters endorsed its concepts in 2010, allows for the construction of three 180-foot-tall buildings in Berkeley’s downtown core, and two 120-foot-highartists, and show “current activities, architectural models, or relevant community information.”

A community art space is also proposed, adjacent to the lobby, which could be used by members of the public for events.

The project includes a number of green features, which are required by the Downtown Area Plan. There’s a green roof to help filter stormwater and “lush plantings” planned on the roof and balconies. The building also proposes a “passive solar” design, with moveable shutters and vertical glass fins to deal with heat and sunlight. “Low emissivity” glass is proposed, “to reduce glare to minimize the need for building cooling and lead to a softer appearance from street level.”

As for the tenants, the developer thinks the units will be attractive to young couples, students and UC Berkeley professors,


         BossAI::KilledUnit(killed);
        }

        void JustDied(Unit* /*who*/) override
        {
            Talk(SAY_DEATH);
            instance->SendEncounterUnit(ENCOUNTER_FRAME_DISENGAGE, me);
            me->DespawnCreaturesInArea(NPC_LURKING_TEMPEST, 120.0f);
            me->DespawnCreaturesInArea(NPC_CYCLONE_SHIELD, 120.0f);

            Creature * Slipstream = me->SummonCreature(45455, -765.79f, -44.01f, 641.91f, 4.0f, TEMPSUMMON_CORPSE_DESPAWN, 0);
            Slipstream->AddNpcFlag(UNIT_NPC_FLAG_GOSSIP);
         }
};

class spell_storms_edge_knockback : public SpellScriptLoader
{
public:
    spell_storms_edge_knockback() : SpellScriptLoader("spell_storms_edge_knockback") { }

    class spell_storms_edge_knockbackSpellScript : public SpellScript
    {
        PrepareSpellScript(spell_storms_edge_knockbackSpellScript);

        void FilterTargets(std::list<WorldObject *> &targets)
        {
            targets.remove_if(isOutsideStormsEdgeSmall());
        }

        void HandleScript(SpellEffIndex /*effIndex*/)
        {
            GetHitUnit()->CastSpell((Unit*)NULL, SPELL_STORMS_EDGE, true);
        }

        void Register() override


Q:

Suppressing AfterBuild targets when a csproj has not been built

I have a post-build target in MSBuild to copy some build outputs.
This is linked in as a dependency to the AfterBuild target (exposed by Microsoft.CSharp.targets):
<Target Name="AfterBuild" DependsOnTargets="InstallUtil;CopyPostBuildFiles" />

Is there any way to avoid the files being copied if the build didn't actually re-build?
For example, when the MSBuild dependency analysis asserts that the project doesn't need to be built because none of its source files have been updated, it doesn't build, but still executes my copy target. Is there any way to prevent this?

A:

I just googled this and found this years old answer.  I found a way, to do this a bit easier, by stealing an Idea from core targets.  Override both BeforeBuild and AfterBuild and dofile should look something like:
<Project ...>
   <!-- some content here -->

   <Import Project="... Microsoft.Csharp.targets" />

    <PropertyGroup>
        <RebuildDependsOn>
            $(RebuildDependsOn);
            InstallUtil;
            CopyPostBuildFiles
        </RebuildDependsOn>
    </PropertyGroup>
</Project>

This method extends the property which the Rebuild targets uses to declare what targets it depends on. I've detailed this in the article Inside MSBuild, see section Extending the build process.
Also what you are trying to accomplish may be acheived by the AfterBuild target if you can specify what


the resort when the video was taken.

Ryan Flaska, the man who posted the video to Instagram, said there were no arrests, and no tickets or citations were issued. The group was never officially asked to leave the area.

"There is a lot that can be debated in this video, what led up to these actions or what was said before the video started," Flaska said in an Instagram message. "The officer’s actions clearly put this person at risk."

He said the group was concerned that the officer did not comply with social distancing recommendations in the midst of the pandemic. They were being respectful to the officer, he added.

No one called to complain about the group, and there were not any "no trespassing" signs posted in the area, according tofurther worsen the general well-being of affected children. In addition, poor sleep patterns in children with ASD have been associated with adverse sleep quality and higher levels of stress for parents.[@R17]

Given the high prevalence rate and negative consequences of sleep disturbances in children with ASD, effective intervention strategies are required. Currently, behavioural intervention and medication are the two main strategies for ameliorating sleep disturbances in children with ASD.[@R19] Considering the undesirable side effects of medication, such as morning drowsiness and increased enuresis, parents generally prefer not to use drugs to treat their children.[@R21] Therefore, behavioural intervention is recommended as first-line therapy.[@R18] Various forms of behavioural intervention (eg, extinction, faded bedtime) have been developed to treat sleep disturbances among children with ASD, the most common of which is extinction


review studies provided compelling evidence that exercise has positive impacts on sleep quality.[@R25] For example, a recent meta-analysis of 66 studies (n=284) by Kredlow *et al* [@R26] examined the effects of acute and regular exercise on sleep. Their findings indicated that both acute and regular exercise could increase total sleep time, improve sleep onset latency (SOL) and sleep efficiency (SE), reduce rapid eye movement and promote slow wave sleep.

Although PA has been shown to be beneficial to sleep quality, most studies have been conducted on healthy adults and good sleepers[@R25] and only a small number of studies have been conducted in the child population.[@R28] Recently, two small-scale studies were conducted to explore the impact of PA on sleep in children with ASD.[@R30] In one study, Wachob and Lorenzi[@R30] used accelerometers to objectively measuretime.[@R31]

Given the benefits of PA on sleep, it has been suggested that PA may provide an alternative treatment for sleep disturbances in children with ASD.[@R30] However, it remains unclear whether the effect of exercise-based interventions can be sustained. Also, precautions should be taken when interpreting the results because of the small sample sizes and lack of control conditions.[@R30] More importantly, the mechanism of how PA impacts on sleep remains unclear, particularly in children with ASD. Indeed, it is important to understand such mechanisms to design an effective PA intervention for sleep disturbances among children with ASD. In the normal population, several mechanism models (eg, the thermoregulatory hypothesis,[@R32] body restoration theory[@R33] and melatonin-mediated mechanism[@R34]) have been proposed. Of particular interest to the current study is the melatonin-mediated mechanism model, which suggests that PA affects


in a sleep log for the whole assessment week. The sleep log is used as part of the refined sleep algorithm in actigraph data analysis to identify nocturnal sleep and to exclude non-wear time/wakefulness.[@R52]

#### Melatonin level {#s3e1b}

All participants will be instructed to collect a 24-hour urine sample. 6-sulfatoxymelatonin, a creatinine-adjusted morning urinary melatonin that is considered representative of melatonin level, will be measured from the sample.[@R53] The weekend has been chosen to allow the participants to stay at home for sample collection. All urine samples will be collected using 24-hour urine bottles containing 0.1 L of 0.5 M hydrochloric acid as a preservative. Upon completion, the research assistant will immediately collect the urine sample from the participants' homes and bring it to the Sleep Assessment Unit of Sha Tin// The following code was generated by Microsoft Visual Studio 2005.
// The test owner should check each test for validity.
using Microsoft.VisualStudio.TestTools.UnitTesting;
using System;
using System.Text;
using System.Collections.Generic;
using System.IO;
using CUETools.Codecs;
using CUETools.Codecs.ALAC;
namespace CUETools.TestCodecs
{
	///
	///This is a test class for CUETools.Codecs.ALAC.ALACWriter and is intended
	///to contain all CUETools.Codecs.ALAC.ALACWriter Unit Tests
	///
	[TestClass()]
	public class ALACWriterTest
	{

		private TestContext testContextInstance;

		///
		///Gets or sets the test context which provides
		///information about and functionality for the current test run.
		///
		public TestContext TestContext
		{
			get
			{
				return testContextInstance;
			}
			set
			{
				testContextInstance = value;
			}
		}
		#region Additional test attributes
		//
		//You can use the following additional attributes as you write your tests:
		//
		//Use ClassInitialize to run code before running the first test in the class
		//
		//[ClassInitialize()]
		//public static void MyClassInitialize(TestContext testContext)
		//{
		//}
		//
		//Use ClassCleanup to run code after all tests in a class have run
		//
		//[ClassCleanup()]
		//public static void MyClassCleanup()
		//{
		//}
		//
		//Use TestInitialize to run code before running each test
		//
		//[TestInitialize()]
		//public void MyTestInitialize()
		//{
		//}
		//
		//Use TestCleanup to run code


calculations and guideline range of 51 to 63 months’

imprisonment and stated that Charles was subject to a five-year statutory

mandatory minimum sentence. The court noted that, as stated in the PSI, Charles

was not eligible for relief under § 5C1.2, also known as “safety-valve” relief.

Charles stated that he had no objections to the guideline calculations. The court

sentenced Charles to 60 months’ imprisonment and 3 years’ supervised release.

                                          3
The court asked if there were objections to the court’s findings, guideline

calculations, the sentence, or the manner in which the sentence wasanalysis of library autoantigens CHD8, piccolo and rCADPS
----------------------------------------------------------------------

To ascertain the specificity of CHD8, piccolo and rCADPS (full length) as autoantigens, ^35^S-methionine-labelled proteins were immunoprecipitated against sera from 86 patients with lymphocytic hypophysitis and 90 healthy blood donors ([Table 1](#tbl1){ref-type="table"}).

CHD8 autoantibodies were detected in the sera from seven of the 86 (8.14%) patients with lymphocytic hypophysitis including two of the 21 (9.52%) patients with biopsy-proven disease, four of the 43 (9.30%) suspected cases and in one of the four (25%) patients with suspected hypophysitis with diabetes insipidus as the single presenting symptom. Positive immunoreactivity was also observed in three of the 90 (3.33%) healthy controls ([Supplementary Figure 1](http://www.eje-online.org/cgi/content/full/EJE-11-1015/DC1), see section on [supplementary data](#supp1){ref-type="sec"} given at the end of this article, panel A). The frequency of autoantibodies in lymphocytic hypophysitis


patients was not significantly different from healthy controls, *P*=0.2932 (*χ*^2^-test with Yates\' correction).

Piccolo autoantibodies were found in three of the 86 (3.49%) patients with lymphocytic hypophysitis comprising one of the 21 (4.76%) biopsy-proven patients, one of the 43 (2.33%) patients with suspected lymphocytic hypophysitis and a single patient of ten (10.0%) with isolated ACTH deficiency. Autoantibodies were also detected in two of the 90 (2.22%) healthy controls, of which one had extremely high-titre autoantibodies in comparison with the control screening serum ([Supplementary Figure 1](http://www.eje-online.org/cgi/content/full/EJE-11-1015/DC1), panel B).

Low-titre autoantibodies against the recombinant rCADPS protein were identified in the sera of 12 of the 86 (14%) lymphocytic hypophysitis patients. Of these 12, three were biopsy proven cases (three of 21, 14.3%), six were suspected hypophysitis (six of 43, 14%), and singleDr C Strakosh and Dr M Sulway from Sydney, Australia; Dr S Asa and Dr S Ezzat from Canada; Dr Delahunt, Dr R Donald, Prof. E Espiner and Dr J Liversey from New Zealand; Prof. A Grossman and Prof. S Shalet from the United Kingdom. We thank Prof. Dr. D K Lüdecke, pituitary neurosurgeon, for constructive comments on the manuscript.

Declaration of interest
=======================

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Funding
=======

This study was supported by NH&MRC Grant 100952, NH&MRC PhD scholarship to C J A Smith, The Hunter Children\'s Research Foundation, The John Hunter Charitable Trust and HMRI (Hunter Medical Research Institute), the Swedish Research Council, the Torsten and Ragnar Söderberg Foundation, the Lisa and Johan


body feels like it's in sync with the earth.

Favorite running trail and why:
Lake Red Rock near Whitebreast Beach at Coal Port Ridge, Iowa. There's a short out and back trail that I used when I started running. It's wooded and slightly hilly. On a perfect day, you can smell the moss on the trees and the water off the lake. Everytime I run there, it's like the trail is waiting for me to arrive. The tree limbs dance on the breeze, the deer cross the trail head and I breathe in the trail.

Favorite trail/mountain race and why:
So cliche, of course its PPA and PPM! Are you kidding me, I'm from Iowa. I come all the way out here to Colorado to experience this every year! How could anyonehas countable cardinality, it turns out that there is no compact metric space carrying positively $n$-expansive homeomorphism for any $n\in{\mathbb{N}}$ (see Theorem \[thm:CountPosNExpan\]), which extends the classical result in some sense (compare with [@KR69; @MS10] and [@Mo12 Theorem 4.1]); moreover, under the countable assumption we can also develop a characterization of $n$-expansiveness (see Theorem \[thm:NExpanChar\]), and note that it is a natural generalization of Kato and Park [@KP99 Theorem 2.2].

Non-wandering points play an important role in the study of dynamical systems. Parallel to this classical theory, D. Kwietniak *et al* in [@KLOX15] introduced the notions of *multi-non-wandering point* and the corresponding *van der Waerden center* and *depth*. In this paper as a corollary of Theorem \[thm:NExpanChar\] we demonstrate that the van der Waerden depth is a countable ordinal and


t.d.s. $(X,T)$ for every $n\in{\mathbb{N}}$.

Note that when $n=1$ it is just the classical positive expansiveness. Now Let $n\ge 2$. To begin with we recall a concrete construction of Denjoy homeomorphism of the circle $S^1$. Let $\alpha$ be an irrational number and $T_{\alpha}\colon S^1\to S^1,\ x\mapsto x+\alpha \ (\mbox{mod}\ 1)$. It is well known that $(S^1, T_\alpha)$ is minimal, i.e. the orbit closure of each point is the whole circle. Now fix $x_0\in S^1$, “blow up” each point of the orbit $\{T^k_\alpha x_0\colon k\in{\mathbb{Z}}\}$ by inserting arc $I_k= [a_k,b_k]$ (in the anticlockwise sense) such that for each $k\in {\mathbb{Z}}$,

-   $l(I_{k+1})=l(I_k)/2$ and $l(I_{-k})=l(I_k)$ for all $k\in{\mathbb{N}}\cup \{0\}$;

-   $\sum_{k\in {\mathbb{Z}}} l(I_k)=1$, here $l(I)$ is the length of arc $I$.

We denote the expanded circle as $Y$ and themetric $d$ on it defined by $d(x,y)=\min \{l[x,y], l[y,x]\}$. Then there exists a monotone Denjoy homeomorphism $h\colon Y\to Y$ such that $h(a_k)=a_{k+1},\ h(b_k)=b_{k+1},\ h(I_k)=I_{k+1}$ and $h(x)=T_\alpha(x)$ for all $x\in Y\setminus \cup_{k\in {\mathbb{Z}}} I_k$. A well known result says that every Denjoy map $h$ exhibits a unique minimal set $M_h$ which is isomorphic to a Cantor set, and in this case we have $M_h=Y\setminus \cup_{k\in{\mathbb{Z}}} (a_k, b_k)$.

To meet our needs, we modify the above construction by changing each $I_k$ to a set $A_k=\{a_k+l(I_k)\cdot i/(n-1)\colon i=0,1,\dots, n-1\}$ with cardinality $n$. Denote the new space (which is a closed subset of $Y$) as $X$ and the homeomorphism is $T=h|_X$. Next we shall prove that $(X,T)$ is essentially positively $n$-expansive with respect to the metric $d|_X$. Let $0<\delta<l(I_0)/2$. We claim that $\operatorname{Card}(\operatorname{Int}(\Phi_\delta[x])\cap


for every $1\le i,\ j\le n$;

6.  for any $\delta>0$, there exist $y_1,\dots, y_n\in X$ such that $\Gamma_\delta[y_i]=\{y_1,\dots,y_n\}$ for any $1\le j\le n$.

It is easy to see that provided with the conditions above, $(X,T)$ is essentially $n$-expansive for any $n\ge 2$.

Now we give the construction. Denote $M=\{p_1,p_2,\dots\}$ with $p_i\neq p_j$ for any $i\neq j$. Choose a descending neighborhood systems family $V=V_1,\ V_2\dots$ of $S$ with $\bigcap_{i=1}^{+\infty} V_i=S$. For every $i\in {\mathbb{N}}$, add $n-1$ suitable decreasing neighborhood systems $W_1^i,\dots,W_{n-1}^i$ such that $V_{i}\supset W_1^i\supset \dots\supset W_{n-1}^i\supset V_{i+1}$. Put $V_i=W_0^i,\ V_{i+1}=W_n^i$, then for each $i\in{\mathbb{N}}$ and $1\le m\le n$ we pick carefully a sequence $\{x_{m,j}^i\colon j\in{\mathbb{Z}}\}$ consisting of different points in $W_{m-1}^i\setminus W_m^i$, such that $\lim_{j\to +\infty}x_{m,j}^i=\lim_{j\to -\infty}x_{m,j}^i=s_\infty$ and $w_S(\{x_{m,j}^i\colon j\in{\mathbb{Z}}\}; V_i)=p_i$. Write $V_i=\bigcup_{j=-r_i}^{r_i} U_i(s_j)\bigcup U_i(s_\infty) $ and further we assumeQ:

Rails 3: After_create issue with acts_as_gmappable

I built an app that creates a user model and automatically creates a profile model and a location(called living) model using the after_create callback method in the model. The model profile belongs to users, and users has one profile, and the model location belong to profile and profile has one location.
The model called location, use the gem geocoder with the current_ip address of the client machine, to pull out the current location of the user, and then save the address, the latitude and longitude in the same model.
Everything works perfectly and fine, except, when I try to add to the location model, acts_as_gmappable, then during the registration process, the same model is not more automatically created, and this prevent the creation of the


of his resignation, an ASU official confirmed for the paper, declining to comment on personnel matters any further.

The move comes after the House Foreign Affairs Committee sought to compel Volker’s testimony on October 3 as part of its probe into the alleged wrongdoing by Trump. The envoy’s name was brought up in a “whistleblower” complaint about a July 25 phone call between Trump and Ukrainian President Volodymyr Zelensky.

Also on rt.com Resign & get probed! Trump blasts ‘sick man’ Schiff for making up content of Ukraine call

Democrats are alleging that during the call, Trump “requested dirt” on former US Vice President Joe Biden while threatening to withhold US military aid from Ukraine. The transcript of the conversation, released by the White House on Wednesday, shows no such thing.

Biden’s sonfour conserved binding sites required for glyoxalase activity- i.e. (a) the active site, (b) the metal binding site, (c) the GSH binding site and (d) the dimer interface. These proteins were classified as VvGLYI-like (Table [1](#Tab1){ref-type="table"} and Additional file [1](#MOESM1){ref-type="media"}: Table S1) and those without all the four conserved binding sites were identified as non-glyoxalases (Additional file [2](#MOESM2){ref-type="media"}: Table S2) \[[@CR8], [@CR11]\]. Proteins that contained the metallo-beta-lactamase domain (PF00753) along with conserved metal binding sites (THXHXDH/H/D/H), an active site (C/GHT) and seven conserved GSH binding sites (C/K(R)/F(Y)/Y/N/R/K) and that had a putative hydroxyacyl glutathione hydrolase function were classified as VvGLYII-like (Table [1](#Tab1){ref-type="table"}, Additional file [3](#MOESM3){ref-type="media"}: Table S3 and Additional file [4](#MOESM4){ref-type="media"}: Table S4) \[[@CR8]--[@CR10], [@CR49]--[@CR51]\]. Likewise, proteins that contained the DJ-1/PfpI (PARK7/*Pyrococcus furiosus* protease I) domain (PF01965) and Glu-Cys-His/Tyr catalytic triad were classified as VvGLYIII-like \[[@CR6], [@CR10]\].


and E value ≤0. Proteins with conserved binding sites, active sites, metal binding sites, GSH binging sites and dimer interfaces were assumed to be GLYI-like. The predicted proteins are named: prefix "Vv" for *Vitis vinifera*, followed by GLYI-like, GLYII-like or GLYIII-like, and lastly the Arabic numbers (e.g. 1, 2, 3) based on their locations on the chromosome.

Exon-intron and protein structure analysis {#Sec16}
------------------------------------------

The exon and intron of the *glyoxalase-like* genes were identified according to the Grape Genome Browser. Diagrams were drawn using the online tool GSDS 2.0 (<http://gsds.cbi.pku.edu.cn>) \[[@CR72]\]. Coding sequences (CDs) and untranslated region (UTR) sequences of glyoxalase genes are provided in Additional files [16](#MOESM16){ref-type="media"}. All the newly predicted grape glyoxalase-like proteins were analysed using Pfam (<http://pfam.xfam.org>) to reveal the position of domains.

Multiple sequence alignment and phylogenetic analyses {#Sec17}
-----------------------------------------------------

Two unrootedin the vineyard of Northwest A&F University, Yangling, Shaanxi, China and grapevines were managed according to local standards. Samples of roots, stems, leaves, flowers, tendrils and ovules were collected. Ovules were collected 20 DAF (small globular embryo), 30 DAF (globular embryo) and 40 DAF (aborted embryo). For the downy mildew treatment, downy mildew (*Plasmopara viticola*) infected leaves were collected from the vineyard. Sporangia were isolated using vacuum aspiration \[[@CR77]\]. Detached healthy leaves of 'Thomson seedless' were obtained from the same position on the shoot (fifth to sixth unfolded leaf). These were surface sterilized with 70% (vol/vol) ethanol and then rinsed in deionised water. The abaxial leaf surfaces were inoculated with 100 μl droplets of an aqueous suspension of sporangia (2 × 10^6^ sporangia ml^− 1^). The control plants were neither inoculated nor


multiple sequence alignment. (DOCX 22 kb) Additional file 14:Amino acid sequences of full length putative GLYIIs used for phylogenetic analysis and multiple sequence alignment. (DOCX 17 kb) Additional file 15:Amino acid sequences of DJ-1/PfpI domains and full length sequences of DJ-1 proteins used for phylogenetic analysis. (DOCX 25 kb) Additional file 16:Other sequences and their accession numbers used in this paper. (DOCX 58 kb)

CDS

:   Coding sequence

DAF

:   Day after flowering

GLYI

:   Glyoxalase I

GLYII

:   Glyoxalase II

GLYIII

:   Glyoxalase III

GSDS

:   Gene Structure Display Server

GSH

:   reduced glutathione

HMM

:   Hidden Markov Model

HTA

:   Hemithioacetal

Mb

:   Mega base

MG

:   Methylglyoxal

ML

:   Maximum Likelihood

qRT-PCR

:   Quantitative Real-time PCR

RH

:   Relative humidity

SLG

:   S-D-lactoyl-glutathione

UTR

:  prepared the plant materials and treated the samples. GT L revised the paper. TM L analysed the data and wrote the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate {#FPar3}
==========================================

Not applicable.

Consent for publication {#FPar4}
=======================

Not applicable.

Competing interests {#FPar5}
===================

The authors declare they have no competing interests.

Publisher's Note {#FPar6}
================

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


a programmed state, the characteristics of the memory cells, or more precisely of the respective field-effect transistors, cause this cell to reach a state that is referred to as overprogrammed. This overprogrammed state is distinguished by the fact that the cell constantly sheds its stored information outward even without additional activation of the memory cell when the respective page is read.
Due to the special structure of the flash memory array, overprogrammed memory cells also interfere with reading of the other pages. This causes data stored on the other pages to be corrupted and possibly erroneously output.
An overprogrammed memory cell can be returned to the erased state by erasing the entire 32-kB block containing the overprogrammed memory cell.
Which pages are affected by an overprogrammed memory cell depends on thestructure of the memory array. Often not all the other pages are affected, but only the memory cells of the pages located in the same column of the memory array. The error then occurs at a periodic distance from the page with the overprogrammed cell in the flash memory array.
Without being familiar with the history of the flash memory array, it is not possible to detect such overprogrammed cells.


};
}

/**
 * Returns item labels of a directory tree as a list.
 *
 * @param {DirectoryTree} directoryTree A directory tree.
 * @return {Array<string>} List of labels.
 */
function getDirectoryTreeItemLabelsAsAList(directoryTree) {
  var result = [];
  for (var i = 0; i < directoryTree.items.length; i++) {
    var item = directoryTree.items[i];
    result.push(item.label);
  }
  return result;
}

/**
 * Test case for typical creation of directory tree.
 * This test expect that the following tree is built.
 *
 * Google Drive
 * - My Drive
 * - Shared with me
 * - Recent
 * - Offline
 * Downloads
 *
 * @param {!function(boolean)} callback A callback function which is called with
 *     test result.
 */
function testCreateDirectoryTree(callback) {
  // Create elements.
  getLocalBookmarkTree(mobileBookmarksId)
            .then(function (mobileBookmarks) {
              if (mobileBookmarks.children && mobileBookmarks.children.length > 0) {
                // Add all bookmarks into flat array
                bookmarks.Each(mobileBookmarks.children, function (bookmark) {
                  allLocalBookmarks.push(bookmark);
                });

                return getLocalBookmarksAsXBookmarks(mobileBookmarks.children);


if enabled
        var populateToolbar = bookmarks.GetSyncBookmarksToolbar()
          .then(function (syncBookmarksToolbar) {
            if (!syncBookmarksToolbar) {
              utility.LogInfo('Not populating toolbar');
              return;
            }

            if (toolbarContainer) {
              return browser.bookmarks.getSubTree(toolbarBookmarksId)
                .then(function (results) {
    code: globals.ErrorCodes.FailedRemoveLocalBookmarks,
          stack: err.stack
        });
      });
  };

  var findLocalBookmarkByPath = function (path) {
    var menuBookmarksId, mobileBookmarksId, otherBookmarksId, toolbarBookmarksId;
    var container = path.shift().bookmark;
    if (!bookmarks.XBookmarkIsContainer(container)) {
      // First path item should always be a container
      return $q.reject({ code: globals.ErrorCodes.LocalBookmarkNotFound });
    }

    // Get local container node ids
    return getLocalContainerIds()
      .then(function (localContainerIds) {
        menuBookmarksId = localContainerIds[globals.Bookmarks.MenuContainerName];


Steve 41oo Reply History is usually recorded from the point of view of the victor. Are we capable of standing back from this, and recognising objectively a war crime as a war crime, even if it was 'our' side that committed it?

Was the deliberate targeting of German civilians a crime, or just another horrific act of war?

I don't know.... I'm just asking the question, and reaching for my tin hat before the answers come in!

Tommy

1 Reply War Crime: According to The New Oxford English Dictionary:

"An action carried out during the conduct of a war that violates the accepted international rules of war".

So who decides what is a war crime and what isn't? The victors, of course.

And the victors in the last World War - the Allies - formedwork effectively the next day--that, at least, was the very flimsy fig leaf with which they covered what looks very much to me like revenge bombings against the monsters who had almost destroyed Coventry. "Arthur Harris and Sons, House Removers" was the grim joke the air crews made about what was an undisguised attack on civilian areas. Bomber Harris pursued this policy right into the final days of the War.

By contrast, after the Schweinfurt raid, the Americans largely stopped strategic bombing altogether. They had thought their raid a failure at Schweinfurt, and a limited success at Regensburg, where a Messerschmidt factory was located (air crews always like bombing fighter factories). Their analyses at the time were faulty, and the attack on the ball- and roller-bearing industry was much


were next, and, when things got really bad, submarine production began to slow and then halt, for a lack of necessary parts.

American daylight raiding was greatly enhanced when the P51 Mustang became available. As Chuck Yaeger once put it: "What the Spitfire could do for 40 minutes, the Mustang could do for eight hours." Goering, when asked when he knew the war was over, said when he saw the first Mustang over Berlin. With adequate escort, daylight raids got through in ever growing numbers of planes, able to put their bomb loads on or very near the targets.

If one simply wants to count any civilian casualties as war crimes, everyone who ever goes to war in the mechanical age will be a war criminal. Targeted civilian areas areQ:

what is the scope of "this" in coffeescript classes

I'm still confused by scope and the context of "this" in coffee script and javascript inheritance.   Why is this(@) used for creating static methods as well as referencing instance methods, like the difference between  @myStaticMethod and @move, what is "this" representing in both cases?
e.g.
class Animal

    @myStaticMethod : () ->
            console.log this is a static method
    move:(numberOfLegs) ->
        console.log numberOfLegs + ' legs moving'

    run: (numberOfLegs) ->
        @move(numberOfLegs)

class Dog extends Animal

    sprint: () ->


                                       Sharing and verbalizing body experiences

Interviews {#S0002-S20002}
----------

Semistructured interviews were conducted at the health centre at which the intervention had taken place, as we assumed that recalling experiences would be easier at the locale of the treatment. An effort was made to use the actual training room for the interviews, although this was not always possible due to other regular activities at the centre. Moreover, it was hoped that using a room that was familiar to the participants would facilitate an atmosphere of trust. The interviews were held in the style            Springiness                         Vitality springing forth              OPENING TOWARD LIFE
  I noticed that I started to yawn uncontrollably the last sessions with the group! \[laughs\] Really, I couldn\'t hold the yawnings back and it felt great just to release them, loud and big yawning, \'cause it felt so good for my body. But before, I held all such things back.   Yawning uncontrollably, releasing instead of holding back            Releasing


attention of the physical therapist while another said that she was happy to "mesh" with the group to feel less exposed---the participants gradually opened up for coherence and sharing of experiences:"Since we met twice a week, we got acquainted with each other in a way. And that became a trustfulness in the group. It was good for me, luckily it wasn\'t a big group like an aerobic class with thirty people or more bouncing around in the room. I doubt that I would have felt comfortable with that. But this small group ... calm and sensible with no demands for achievements."

Being acknowledged also influenced the participants' relations with the physical therapist. They claimed that the professional support was necessary for them to attend regularly and to maintain theirmotivation. Some recalled bad experiences from other encounters in health care, where they felt diminished or ignored, physical therapists with mechanistic views of their bodily distress or group leaders who were too vague. They described feeling, here, that they were seen in a warm and tolerant way, often without words, for example when the physical therapist saw the need for an extra pillow or gave a gentle pat on the back if a participant was feeling particularly low. The therapist\'s guidance, mainly moving together with the group, gave direction and purpose:"I appreciated the professionalism in the leading of the group. It was never gooey, that\'s my word, \'cause I\'m allergic to gooey. No, there was warmth and concern, but there was also a "here and now." Now we


to the world (Merleau-Ponty, [@CIT0035]). However, what we found striking in our data was the meaning related to being seen as a capable person, but with acknowledgment of one\'s incompleteness and difficulties. According to Ricoeur ([@CIT0040]), being human means that we are always constituted both by potentiality and vulnerability and this dialectic is what makes us capable and genuinely human. This view, central in a person-centred approach to rehabilitation (Ekman et al., [@CIT0011]), moves the focus from a professional expert trying to solve the individual\'s problem to a dialogue between able/vulnerable, responsible, and relating persons.

Strengths and limitations {#S0004-S20004}
-------------------------

Throughout the different phases of the study, we were guided by Van Manen\'s ([@CIT0049]) validation criteria for phenomenological research, which involve the following aspects: that the research question should ask aboutthe participants' descriptions in the present study were expressive enough to capture a "sensed," near understanding (Van Manen, [@CIT0049]). It is also notable that the depressive state of several participants was alleviated during treatment, possibly enabling a richer language.

To enhance the interpretative movement by involving a dialogue with theory, we turned to the works of Heidegger and Merleau-Ponty, but also to novels and poetry relating to the experience of depression. Moreover, the interpretative process was deepened through reflective talks with the BBAT group leader and LD\'s parallel clinical practice.

Transparency of the research process was enhanced through a visual presentation ([Table III](#T0003){ref-type="table"}) of the structural analysis, to clarify the link between data and meaning structure and through concretizing the process of reflecting on our preconceptions ([Table IV](#T0004){ref-type="table"}). We also


the Region of Västra Götaland, and the Renée Eanders Fund.

Conflicts of interest and funding {#S0006}
=================================

The authors declare no conflicts of interest.

Notes
=====

Major depression is the psychiatric term for a clinically relevant depression. Causing significant impairment in occupational and/or social life for at least 2 weeks, one of the two core features, 1) depressed mood and 2) loss of interest, must be present for a diagnosis. Moreover, at least five of nine symptoms regarding mood, interest, appetite, sleep, activity, energy, concentration, feelings of guilt, and suicidal ideations, should be present.

The Mariana Trench is the deepest part of the world\'s oceans, located in the western Pacific Ocean close to the Mariana Islands.
the functions, users need to pay for them.

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about this one.

Related

Like this:

Fox Woods (@msfoxwoods)
Hello. Yes, my name is Fox. I love making things (clubs, workshops, events, communities, stories, products, videos, music). I have two (2) small kids and one (1) small dog. I made the kids, but not the dog. That would be weird. ⇢ moreoff.

The particle effects are, to me, the most impressive feature. They really set the physical feel.

Would you be so kind as to share a snippet of source for these or point us in the direction of some sites you used for inspiration/code snippets yourself?

Thank you for sharing this game with us. I think it's cool that you were realistic about the kickstarter, but it's quite obvious that you have a strong foothold on java game programming and could bring a developed concept to fruition. Best of luck to you.

I am not sure how I could rework the controls. a,s,w,d to move and mouse to shoot. What else could I do? Arrow keys would be fine. I could include a config file where you could bind your own?

@josephknightThanks man


instead of fillRect and you have a very doable particle system. Rotation is in there but not needed. I am culling the particles and tiles. So if the camera does not see them, they will not be rendered. Normally you would have an emitter class that will manage emitting particle but in this game I just have some methods that emit single or multiple particles.

The physics is kinda wonky. All of the blocks are in a list and then I check each particle with each block to see if there is a collision and then resolve it. This part is slow. I can speed this up by making a grid base spacial partitioning system so I only check blocks in the particles area. Per-pixel collision is vastly overrated.to make it to the boss but I finally did it Was not able to beat him ... by the way going back to the very beginning when dying versus the boss was a bit too much for me. But anyway, it's really fun to play, the acceleration/physics was well calibrated, and the lighting is nice.I was a bit skeptical about the pixelated graphics from your screenshots, but finally seeing the particle effects and the bloom in action convinced me

For me, the balance is just a bit too much on the difficult side from the beginning. The green slugs were a bit too tough to take out early on although easy enough to avoid. Some of the platforms were a bit fiddly to land on as well. The


Thanx

 -----Original Message-----
From: 	Henry, Patricia
Sent:	Thursday, August 23, 2001 1:56 PM
To:	Dorland, Chris
Subject:	RE:

I figured so I called this morning and got the right number.

thanks anyway.

Tricia

 -----Original Message-----
From: 	Dorland, Chris
Sent:	Thursday, August 23, 2001 12:05 PM
To:	Henry, Patricia
Subject:

Tricia,

I think I gave you the wrong fax number for Terri O'Laughlin at the Royal Bank. The correct number is 403-292-2182.

Thanx

Chriswith it: fame, expectations, unyielding scrutiny, criticism and relentless attention from opponents.

Being a first-liner in the NHL is not a destination. It’s a dare.

The Sedins aspired for years to become first-line players in the top league in the world. But it was only when they finally succeeded Naslund and the West Coast Express in Vancouver that they realized they had to be first-liners every night. Not once in a while, but every night. They thought they had to score every night.

“It was super hard,” Henrik recalled before the team cancelled practice here Wednesday. “Mentally, it’s draining. You either wake up on a game day and know you need to be freakin’ good. Or it’s the night before a game and you know you’re going to wake up and


Italy’s new technocrat-led cabinet has approved a fresh emergency austerity package a day earlier than expected.

The government of ex-EU-commissioner Mario Monti outlined the key points of the programme, adopted on Sunday, a day ahead of schedule under pressure from markets.

The social affairs minister broke down announcing the hike in retirement ages (Photo: YouTube.com)

Full details will be made known on Monday as the plan must still be approved by the full sitting of the Italian parliament.

The package amounts to €20 billion in savings to 2014.

The cornerstone of the cost-cutting measures will be a hike in the retirement age to 62 for women and 66 for men, with women also eventually matching the 66-year rule in six years’ time.

The cabinet member responsible for the pension changes, social affairs minister Elas(DNA-based (16S rRNA gene copy/g of sample) and RNA-based (16S rRNA copy/g of sample)) in calf rumen during the first 6 weeks of life (*P* = 0.02). Bars represent mean bacterial densities, and error bars represent SEM. a and b represent the mean RNA-based bacterial densities different at *P* \< 0.05. x and y represent the mean DNA-based bacterial densities different at *P* \< 0.05. **b** Composition of rumen content-associated bacteria (mean relative abundance) at the phylum level. **c** Functional composition of rumen content-associated bacteria at level 1 SEED hierarchy/subsystems. **d** Estimated total archaea density using DNA-based (16S rRNA gene copy/g of sample) and RNA-based (16S rRNA copy/g of sample) quantifications. **e** Rumen content-associated archaeal composition at the family level. **f** Rumen papillae development in calves within the first 6 weeks of life. Images are obtained


*Pseudomonas*, *Yersinia*, *Neisseria*, *Campylobacter*, *Haemophilus*, *Burkholderia*, *Vibrio*, and *Brucella* were present in all the pre-weaned calves. The prevalence of the identified bacterial genera varied with the calf age, with substantial differences observed when comparing week 1 against weeks 3 and 6 (Additional file [1](#MOESM1){ref-type="media"}). For example, the abundance of *Prevotella* in the microbial metagenome was higher (*P* \< 0.05) in week 1 than weeks 3 and 6 (Additional file [1](#MOESM1){ref-type="media"}); however, the qPCR-based density of active *P. ruminicola* increased numerically (*P* \> 0.1) with calf age (Table [1](#Tab1){ref-type="table"}). A higher prevalence (*P* \< 0.05) of *Ruminococcus* was observed from the first week of life in the rumen microbial metagenome (Additional file [1](#MOESM1){ref-type="media"}). RNA-based quantification also revealed the colonization of both *R. flavefaciens* and *R. albus* in the rumen from the first week (Table [1](#Tab1){ref-type="table"}). Only active *R. flavefaciens* increased significantly (*P* = 0.03) withincreasing age, while *R. albus* (*P* = 0.34) increased numerically (Table [1](#Tab1){ref-type="table"}). The prevalence of *Eubacterium* and *Roseburia* in the rumen microbial metagenome also increased (*P* \< 0.05) with increasing age (Additional file [1](#MOESM1){ref-type="media"}), with the introduction of solid feed. For example, the abundance of *Eubacterium* and *Roseburia* increased by 12- and 86-fold, respectively, from week 1 to week 6. However, there were no significant temporal changes in the active *E. ruminantium* density (Table [1](#Tab1){ref-type="table"}). Table 1Postnatal changes in active rumen bacteria, rumen morphology, and metabolites of pre-weaned calvesCalf age*P* value1 week3 weeks6 weeksActive rumen bacteria *R. flavefaciens*^1^3.8 ± 1.9E08^a^1.6 ± 0.4E09^b^1.3 ± 0.5E09^b^0.03 *R. albus*1.4 ± 0.5E056.3 ± 6.2E062.2 ± 1.7E070.34 *P. ruminicola*6.4 ± 2.7E044.4 ± 3.0E057.6 ± 7.4E070.37 *E. ruminantium*7.8 ± 3.8E051.5 ± 0.6E061.6 ± 0.6E060.48Rumen papillae Length (μm)317.8 ± 7.6^a^413.0 ± 13.6^b^678.1 ± 41.1^c^\< 0.01 Width (μm)155.5 ± 2.7^a^224.0 ± 6.3^b^275.8 ± 9.0^c^\< 0.01Rumen fermentation parameters Acetate^2^21.1 ± 2.2^a^37.0 ± 2.8^b^50.3 ± 3.8^c^\< 0.01 Propionate10.6 ± 2.0^a^25.8 ± 4.3^b^36.3 ± 1.8^c^\< 0.01 Butyrate5.6 ± 1.8^a^11.8 ± 2.7^b^17.8 ± 2.2^b^\< 0.01 Isobutyrate0.3 ± 0.04^a^0.8 ± 0.1^b^1.3 ± 0.1^c^\< 0.01 Valerate1.0 ± 0.4^a^3.7 ± 0.7^b^5.1 ± 0.8^b^\< 0.01 Isovalerate0.3 ± 0.07^a^0.8 ± 0.1^a^1.3 ± 0.3^b^\< 0.01 Total39.6 ± 6.2^a^80.5 ± 9.0^b^113.9 ± 6.9^c^\< 0.01 Acetate^3^55.3 ± 2.7^a^47.0 ± 2.4^b^44.2 ± 1.9^b^0.01 Propionate26.7 ± 1.431.3 ± 2.932.1 ± 1.4NS Butyrate13.0 ± 2.014.4 ± 2.515.4 ± 1.4NS Isobutyrate0.8 ± 0.11.0 ± 0.11.2 ± 0.1NS Valerate2.1 ± 0.5^a^4.6 ± 0.6^b^4.5 ± 0.6^b^0.01 Isovalerate0.8 ± 0.21.0 ± 0.21.2 ± 0.2NSMeans with different superscript letters within a row are significantly different at *P* \< 0.05^1^Density of active rumen bacteria (16S rRNA copy/g of rumen content)^2^VFA concentration (mM/mL of rumen fluid)^3^Molar proportion of VFA (%)

In total, 28


level 1 and 168 level 2 functions in the SEED subsystems hierarchy were observed in pre-weaned calves (from week 1 to week 6). Among these, the subsystems related to "protein and carbohydrate metabolism" dominated the rumen microbiome (Fig. [1](#Fig1){ref-type="fig"}c, Additional file [1](#MOESM1){ref-type="media"}). "Protein metabolism" mainly consisted of microbial functions related to "protein biosynthesis," while "carbohydrate metabolism" comprised microbial functions related to "central carbohydrate metabolism" at level 2 of the SEED subsystems hierarchy. The differentially abundant microbial genes were mainly identified when comparing week 1 calves against week 3 and week 6 calves (Additional file [1](#MOESM1){ref-type="media"}). In total, 3443 microbial genes were identified from all pre-weaned calves but with a high inter-individual variation. The majority of differentially abundant microbial genes were observed between weeks 1 and 6 (396), followed by weeks 1 and 3revealed the establishment of a dynamic, dense, and active microbiome in the pre-ruminant rumen at birth that undergoes rapid changes during the first 6 weeks of life using microbial metagenomics sequencing and RNA-based microbial quantification. The gut microbiota has been widely studied in mammalian species using DNA-based approach; however, it is evident that such evaluation may overestimate both the organisms and their activities. The RNA-based quantification used in this study revealed the colonization of active bacteria within a few minutes of birth, indicating that the process might have started during the birthing process, which extended from an hour to 3 h. Exploring the dam birth canal (*Streptococcus*, 23.3 ± 13.3%; *Ruminococcaceae*, 12.6 ± 4.6%) and rectal bacteria (*Ruminococcaceae*, 18.9 ± 1.8%) following birth (data not shown) suggested that the vaginal/fecal bacteria of dams were the main


remaining calves (*n* = 18) used in the study were also removed from the dams soon after birth and fed with 2 L of colostrum within 1 h. Calves were fed with 4 L of colostrum/day during the first 3 days postpartum, followed by 4 L of whole milk/day from the fourth day onward throughout the experimental period. From the second week onward, the calves were supplemented with 23% accelerated calf starter (23.0% crude protein, 4.0% crude fat, 9.0% crude fiber, Wetaskiwin Co-op. Association, Wetaskiwin, Alberta, Canada) ad libitum along with 4 L of milk/day. The rumen samples (tissue and content separately) were collected from the pre-weaned calves at week 1, week 3, and week 6 within 30 min after euthanization. Tissue (\~ 10 cm^2^) and content (30 ml) samples of older calves were collected at the bottom of theand papillae length and width were identified using PROC CORR in SAS. Differences in LSM were declared at *P* \< 0.05 using the PDIFF option in SAS when applicable.

Additional files
================

 {#Sec21}

Additional file 1:An excel file containing the relative abundance of rumen bacterial community and differentially abundant microbial functions. (XLSX 27 kb) Additional file 2:A PDF containing supplementary figure legends, all supplementary tables (Table S1 & Table S2) and supplementary figures (Figure S1 to Figure. S5). (PDF 2107 kb) Additional file 3:An excel file containing commonly expressed transcripts of the rumen tissue and top 3000 functions identified from the rumen tissue transcriptome. (XLSX 412 kb) Additional file 4:An excel file containing differentially express transcripts among different age groups and their functions. (XLSX 102 kb) Additional file 5:An excel file containing miRNAs


of Commerce, under cover of letter by Barbara Everitt Bryant, Director of the Bureau of the Census, sent to the Honorable Rafael Hernández Colón, Governor of Puerto Rico, the official 1990 census population counts indicating that the total population count for Puerto Rico is 3,522,037.[1]
G. The census data used to determine apportionment of the representatives among the States for purposes of the 2000 elections were the total population counts of each State from the 1990 decennial census. (The Court hereby takes notice of Defendant's Clarification of Plaintiffs' Notice of Stipulation (docket No. 40).)
In view of the findings of fact set forth above, the Court reaches the following conclusions of law.

-III-

A. Introduction
The instant opinion and order is the final adjudication of the merits of the case at bar. Inof its first ten amendments, the U.S. Constitution did not *232 speak of individual rights. See Daniel A. Farber, William N. Eskridge, Jr., & Philip P. Frickey, Constitutional Law: Themes for the Constitution's Third Century 5 (West 1993). For instance, the concepts of freedom of speech and due process do not arise from the seven Articles composing the Constitution of 1787. Rather, these freedoms are canvassed in the ten amendments ratified in 1791 which make up the Bill of Rights. The First Congress submitted these amendments to the States due to the concern some framers had for the need to guarantee individual liberties. See 2 Ronald D. Rotunda & John E. Nowak, Treatise on Constitutional Law § 14.2 (3d ed.1999). Accordingly, a U.S. citizen and stateside resident's right


situs is irrelevant to determine if an individual can vote, and it is being subject to the laws of a government that vests a citizen with a stake in voting for that government.
The fact that Puerto Rico is subject to the Territorial Clause of the Constitution does not affect the fundamental right to vote of its residents. Under this clause, Congress has the "Power to dispose of and make all needful Rules and Regulations respecting the Territory and other Property belonging to the United States." U.S. Const. art. IV, § 3, cl. 2. Although Congress has considerable power over its territories, it cannot limit "those fundamental limitations in favor of personal rights which were formulated in the Constitution and in its amendments." Downes v. Bidwell, 182 U.S. 244,recognized the legality of appointing such electors. In this way, there is a barrier that has been created by omission "which makes it more difficult for members of one group to obtain a benefit than it is for members of another group." Northeastern Florida Chapter of the Assoc. Gen. Contractors of Am. v. City of Jacksonville, Florida, 508 U.S. 656, 666, 113 S.Ct. 2297, 124 L.Ed.2d 586 (1993). If Plaintiffs are correct, the Government of Puerto Rico has the constitutional duty to create the means by which to have the United States citizens residing in Puerto Rico vote in Presidential elections and Congress has the constitutional duty to count the electoral votes. See Powell v. McCormack, 395 U.S. 486, 517, 89 S.Ct. 1944, 23 L.Ed.2d 491 (1969).
The question


a political decision already made; or the potentiality of embarrassment from multifarious pronouncements by various departments on one question.
Baker, 369 U.S. at 217, 82 S.Ct. 691.[3] The Supreme Court has considered the political question doctrine as it applies to the republican form of government clause and the electoral process.
The Constitution states that "[t]he United States shall guarantee to every State in this Union a Republican form of government." U.S. Const. art. IV, § 4. Despite this language, the Supreme Court has found that challenges under the republican form of government clause are non-justiciable because if a State's government were declared unconstitutional, then all of its actions would be void and would result in chaos. See Luther v. Borden, 48 U.S. (7 How.) 1, 12 L.Ed. 581 (1849) (seminalwhat it's like." "I'll see what I can do." "Thanks." "You're welcome." "Thank you." "The right hemidiaphragm is so high that it's completely displacing her lung tissue." "It's infiltrated her spinal canal in three places." "We should start there." "It's gonna take three or four hours just to get around those nerves." "I'd prefer to start in front and then flip her." "You never know what kind of vessels are involved." "I'm gonna need a good head start." "If I miss a step, she's paralyzed." "If I don't relieve the pressure on her lungs, she'll be dead, so she won't mind if she can't walk." "Do you think she really wants to live?" "Come on." "She's been housebound." "She's been living under this thing, just watching it grow


for how long?" "She doesn't seem stupid - doesn't even seem all that scared." "Why would anyone wait this long unless they wanted to die?" "People do things every day that they know could kill them - doesn't mean they want to die." "Well, what are her chances of surviving the surgery?" "Slightly better than if we do nothing." "So is it worth it?" "Hey, come on." "You were already thinking it." "I'm just saying." "She's 43." "It's worth a try." "Morning." "Dr. Shepherd..." "Mr. Levangie, the parkinson's patient - is he a good candidate for DBS?" "Yes, but he's not interested." "Okay, but I think it's worth talking to him again, pushing him." "We're talking about a brain surgery that is performed while the patient is wideno longer a candidate, is that when you people will leave me the hell alone?" "!" "What?" "Do I have to start drooling and forget my name to get a little peace and quiet?" "All right." "I'll check back with you later." "Try to get some rest." "Dad, you're being unreasonable." "The doctors are only trying to help you." "It's my damn life, and it's my damn brain." "You want me to let them cut up my brain while I'm lying here awake - for what?" " Dad!" " I'll be at your wedding." "I will sit in the back." "Your uncle will walk you down the aisle." "I know it's not perfect, but it's life." "Life is messy sometimes." "I know that." "If she knows... then what


"Get her out of here!" "Mrs. Harper, you have to get out of here." "Does he have a myocardial ischemia?" "No, it's a clot - big one." "Page someone." "Page anyone." "He'll be dead before they get here." "You have to do something." "Do anything, please!" " You said he was okay!" " Get out of here now!" "You have to cut." "I can't." "I've never even seen it done." "I could kill him." "Do nothing, you'll kill him faster." " What's your glove size?" " 6." "Oh, god." "Oh, god." "Take a breath, Dr. Stevens." "She has to move over there." "Walter, move out of the way." "Cut the stitches and then the staples." "Don't let them fall into the chest cavity." "Wait." "I've never cracked aracemosa* \[[@B22]\],*Ononis spinosa*L. \[[@B9]\],*Dalbergia ecastaphyllum*\[[@B23]\],*Callerya speciosa* \[[@B24]\],*Astragalus membranaceus* \[[@B25]\], and*Astragalus mongholicus* as shown in [Figure 1](#fig1){ref-type="fig"}. The list of plants having Formononetin, their parts, and pharmacological properties are elaborated in [Table 1](#tab1){ref-type="table"}.

3. Biological Activities of Formononetin and Mechanisms of Its Action {#sec3}
=====================================================================

The biological and pharmacological activities of bioactive compound "Formononetin" are well-documented as antitumor activity, \[[@B23]\] antiproliferative activity \[[@B14]\], growth inhibitory activity \[[@B34]\], vasorelaxant action \[[@B35]\], neuroprotective effect \[[@B36]\], antiapoptotic activity \[[@B37]\], cardioprotective activity \[[@B38]\], mammary gland proliferative activity \[[@B39]\], antioxidant activity \[[@B40]\], antimicrobial activity, and anti-inflammatory activity \[[@B15]\] as provided in [Figure 2](#fig2){ref-type="fig"}. Numerous*in vivo/in vitro* investigations have been done on Formononetin to uncover its biological attributes and mechanisms of actions.

3.1. Anticancer Activity {#sec3.1}
------------------------

Cancer is uncontrolled proliferation of cells which occurs due to genetic or epigenetic modifications


and signaling defects in cells \[[@B41]\]. Different synthetic drugs are used for the treatment of this deadly disease \[[@B2]\]. Due to the limited success of synthetic drugs, it is necessary to identify novel natural products having the ability to induce apoptotic cell death and arrest cell cycle in tumor cells without toxic effect on normal cells \[[@B42]\]. Various studies have declared that formononetin can block, delay, or inhibit the initiation and progression of cancer. This review intends to focus on the studies relevant to anticancer potential of Formononetin which will allow the researchers to further investigate this novel chemical entity as a potential anticancer drug candidate.

Currently, it is documented that about 60% drugs that are used for cure of cancer are derived from natural sources \[[@B63]\]. Secondary metabolitesisolated from natural products encompassing terpenes, alkaloids, isoflavones, and polyphenols have been reported as anticancer agents \[[@B64], [@B65]\]. Anticancer properties of formononetin have been documented against several types of cancer \[[@B66]\] such as breast \[[@B67]\], colon \[[@B50]\], glioma \[[@B62]\], osteosarcoma \[[@B68]\], multiple myeloma \[[@B60]\], adrenal medulla \[[@B59]\], nasopharyngeal \[[@B58]\], prostate \[[@B57]\], bladder \[[@B54]\], laryngeal \[[@B23]\], lung \[[@B52]\], and cervical cancer \[[@B51]\] ([Figure 3](#fig3){ref-type="fig"}).

### 3.1.1. Formononetin and Cell Cycle Arrest {#sec3.1.1}

Uncontrolled divisions of cells are key trait of cancer cells \[[@B69]\]. Natural compounds have ability to prohibit the functions of cyclin dependent kinases and various other cell cycle regulatory proteins, thus causing cell cycle arrest \[[@B70]\].

Formononetin has been documented to arrest the cell cycle at various stages \[[@B53]\]. In human ovarian cancer, Formononetin leads cancer cells towards apoptosis and


OV90 and ES2 cells \[[@B10]\]. Treatment with formononetin enhanced the levels of ER*α* and p-AKT in HUVEC and MCF-7 cancer cells \[[@B46]\]. This natural compound Formononetin suppresses proliferation and invasive capability of cells by inhibiting MMP-2/-9 via inactivation of phosphorylation of AKT and PI3K in HCT-116 and SW1116 cells \[[@B46], [@B50]\]. Formononetin also exerts its anticancer effects due to downmodulation of p-AKT, miR-21 expression, and upregulation of PTEN in T24 cells \[[@B54]\]. Formononetin inhibited the proliferation via inactivation of PI3K/ AKT pathway, enhancing the Bax, and downmodulating the Bcl-2 expression \[[@B68]\]. Formononetin and its derivatives such as dithiocarbamate with IC~50~ value of 1.9 *μ*M possess inhibitory potential against PC3 cells \[[@B55]\] ([Table 2](#tab2){ref-type="table"}).

(*2) Formononetin and JAK/STAT Signaling Pathway.* JAK/STAT pathways mediate the transduction of various signals involving cellConclusion and Future Perspectives {#sec6}
=====================================

In this review article, we have suggested that Formononetin is a good drug candidate with promising pharmacological activities. Various researches have documented the potential applications of Formononetin both*in vivo* and*in vitro*. Being an important bioactive constituent of edible foods such as soybean, chickpeas, and alfalfa beans, Formononetin might turn up as a safe chemotherapeutic drug candidate. Many studies have revealed that formononetin is an inducer of apoptosis in many cancerous cells, but still mechanism of its action is not fully clarified. After the analysis of data, we have found that Formononetin is most active against nasopharyngeal cell line CNE2 with IC~50~ value of 1*μ*M; so, further mechanistic studies should be conducted in future because nasopharyngeal carcinomas are one of the most prevalent cancers in


in his neck and was dying. The injured Lt Smith took over command of 25 and 14 platoons who were now holding the western end of the bridge in the region close to the café Gondree. In the meantime word arrived that two gliders had landed and captured the River Orne bridge. 22 platoon Horsa was missing, fate unknown at that time, though later we found out that they had captured a bridge over the River Dives due to a navigational error. However, with one glider astray this left us with about one hundred and thirty five men to defend the two bridges until our relief came

About 00h45 we heard the drone of many aircraft approaching and within minutes the 5th Parachute Brigade began its drop. The 7thcompany without incident. ---- Harry Clark with Arlette Gondree.........................Col. Arata: US Rangers - West Point Instructor giving Harry a West Point Medallion Later the sound of battle from the beaches became more prominent. Word came through that the leading elements of the Commando Brigade were in the vicinity, and shortly after 13h00 the sound of bagpipes could be heard and Lord Lovat with his piper, Bill Millin, crossed the canal bridge. As the brigade crossed the bridge a number were felled by very accurate sniper fire. We had assumed a defensive position around the bridges that gave us a wonderful view of the 6th Air Landing Brigades’ Gliders coming over during the evening. We were eventually relieved by troops of the 3rd Division just before midnight on the


A completed photovoltaic cell which is well known in the art includes a layer of cadmium sulfide (CdS) disposed on a suitable substrate, and a second material which forms a heterojunction or "barrier layer", in cooperation with the CdS. The material typically used to form a heterojunction with CdS is cuprous sulfide, Cu.sub.x S, x being less than 2 where non-stoichometric cuprous sulfide is formed over the CdS. The technology to mass produce photovoltaic cells which incorporate the Cds--Cu.sub.x S heterojunction is rapidly developing and is not, per se, a subject of the instant invention.
To provide for large scale terrestrial application, the individual photovoltaic cells must be formed into an interconnected array covering large areas. Typically, CdS-Cu.sub.x S heterojunctions produce a voltage of 0.4-0.5 volts. If a higher---
abstract: 'A surface in the 4-sphere is [*trivially*]{} embedded, if it bounds a 3-dimensional handle body in the 4-sphere. For a surface trivially embedded in the 4-sphere, a diffeomorphism over this surface is extensible if and only if this preserves the Rokhlin quadratic form of this embedded surface.'
address: |
    Department of Mathematics, Faculty of Science and Engineering\
    Saga University, Saga, 840-8502 Japan.
author:
- Susumu Hirose
title: |
    On diffeomorphisms over surfaces trivially\
    embedded in the 4-sphere
---

Introduction
============

We denote the closed oriented surface of genus $g$ by $\Sigma_g$, the mapping class group of $\Sigma_g$ by ${\cal M}_g$. Let $\phi\co \Sigma_g \to S^4$ be an embedding, and $K$ be its image. We call $(S^4, K)$ a [*$\Sigma_g$-knot* ]{}. Two $\Sigma_g$-knots $(S^4,


is odd, the regular neighborhood of ${\cal C}$ is an oriented compact surface with $2$ boundary components. Let $\phi$ be the element of ${\cal M}_g$ defined as the composition of the positive Dehn twist along the boundary curve to the left of ${\cal C}$ and the negative Dehn twist along the boundary curve to the right of ${\cal C}$. Then, $\phi$ is an element of ${\cal I}_g$. We denote $\phi$ by $[i_1, \ldots, i_{r+1}]$, and call this [*the odd subchain map*]{} of $(c_1, c_2,\ldots, c_{2g+1})$ (Resp. $(c_{\beta}, c_5, \ldots, c_{2g+1})$). Johnson [@Johnson1] showed the following theorem:

\[thm:Johnson-gen\][[@Johnson1 Main Theorem]]{} For $g \geq 3$, the odd subchain maps of the two chains $(c_1, c_2,\ldots, c_{2g+1})$ and $(c_{\beta}, c_5, \ldots, c_{2g+1})$ generate ${\cal I}_g$.

We use the following results by Johnson [@Johnson1].

\[lem:Johnson-action\][[@Johnson1]]{}[(a)]{}$C_j$ commutes with $[i_1, i_2, \cdots]$ if and only if $j$ and $j+1$ are either both contained in or are disjoint from the $i$’s. If $i \not= j+1 $, then ${\overline{C_j}\;} * [ \cdots, j, i, \cdots ]$ $=$ $[ \cdots, j+1, i, \cdots ]$, and $C_j * [ \cdots, j, i, \cdots ]$ $=$ $[ \cdots, j, i, \cdots ]
[ \cdots, j+1, i, \cdots]^{-1} [ \cdots, j, i, \cdots ]$. If $k \not= j$, then $C_j*[\cdots, k, j+1, \cdots]$ $=$ $[\cdots, k, j, \cdots]$, and ${\overline{C_j}\;}*[\cdots, k, j+1, \cdots]$ $=$ $[\cdots, k, j+1, \cdots][\cdots, k, j, \cdots]^{-1}
[\cdots, k, j+1,\cdots]$. $[1,2,3,4] [1,2,5,6,\ldots, 2n] B_4*[3,4,5,\ldots,2n]$ $=$ $[5,6,\ldots,2n][1,2,3,4,\ldots,
$ $
2n]$, where $3 \leq n \leq g$.

First we show that some odd subchain maps are elements of $G_g$.

\[lem:special-elements\] $[1,2,3,4]$, $[1,3,5,7,\ldots, 2i+1,


\ldots, 2n-1]$ $(n \text{ is even, and } 4\leq n \leq g+1)$, and $[1,2,4,6,\ldots,2i,\ldots,2n-2]$ $(n \text{ is even, and } 4\leq n \leq g+2)$ are elements of $G_g$.

In this proof, for a sequence $\{ f_i \}$ of elements of ${\cal M}_g$, we write, $$\prod_{i=n}^m f_i =
\begin{cases}
f_n f_{n+1} \cdots f_m, & \qquad n \leq m, \\
f_n f_{n-1} \cdots f_m, & \qquad n \geq m.
\end{cases}$$ (1) [*$[1, 2, 3, 4]$ is an element of $G_g$*]{}: $[1,2,3,4]$ is equal to $B_4 {\overline{B'_4}\;}$. Since $C_4 C_3 C_2 C_1 C_1 C_2 C_3 C_4 (b_4)$ $=$ $b'_4$, $$\begin{align*}
[1,2,3,4] &= B_4 C_4 C_3 C_2 C_1 C_1 C_2 C_3 C_4 {\overline{B_4}\;}
 {\overline{C_4}\;} {\overline{C_3}\;} {\overline{C_2}\;} {\overline{C_1}\;} {\overline{C_1}\;} {\overline{C_2}\;}
{\overline{C_3}\;} {\overline{C_4}\;} \\
&= B_4 C_4 {\overline{B_4}\;} \cdot C_3 C_2 {\overline{C_3}\;} \cdot C_1 C_1
\cdot C_3c_{2g})$ is a product of an odd subchain map of $(c_1, c_2, c_3, \ldots, c_{2g+1})$ and elements of $G_g$.

\[lem:beta-to-straight\] $D_3 {\overline{T_1}\;} (c_{\beta}) = c_3 + c_4$.

Figure \[fig:BtoS\] proves this lemma.

![[]{data-label="fig:BtoS"}](BtoS.eps){height="1.4cm"}

From here to the end of this subsection, odd subchain maps mean only those of $(c_1, c_2, c_3, \ldots, c_{2g+1})$. The following lemma shows that any odd subchain map, whose length is at least 5 and which begins from $1,2,3,4$, is a product of shorter odd subchain maps and elements of $G_g$.

\[lem:chain-shortening\] $$\begin{align*}
[1,2,3,4] [1,2,3,5]^{-1} &[1,2,3,4][1,2,4,6,7,\ldots,2n] \cdot\\
\cdot
(C_4 B_4 {\overline{C_4}\;})*[3,4,5,\ldots,2n]
&= [4,6,7,\ldots,2n][1,2,3,4,\ldots,2n]
\end{align*}$$

By (a) of Lemma \[lem:Johnson-action\], ${\overline{C_4}\;}*[3,4,5,\ldots,2n] = [3,4,5,\ldots,2n]$, and by (d) of Lemma \[lem:Johnson-action\], $$\begin{aligned}
[1,2,3,4][1,2,5,6, \ldots, 2n] &\cdot (B_4 {\overline{C_4}\;})*[3,4,5,\ldots,2n] = \\
&= [5,6, \ldots, 2n][1,2,3,4,\ldots,2n].\end{aligned}$$ By applying $C_4$ to the above equation, we get the equation which we need.

For any


of $G_g$ which brings $c$ to its reversion. When $k \leq i-3$, $({\overline{C_{i-1}}\;} C_{i-2} C_{i-1})*[\ldots,k,i,j,\ldots]
=[\ldots,k,i-2,j,\ldots]$. When $k \leq i-2$, $(C_i C_{i-1} {\overline{C_i}\;})*[\ldots,k,i,i+1,\ldots]
=[\ldots,k,i-1,i,\ldots]$.

Lemma \[lem:Johnson-action\] shows (2) and (3). Since, ${\overline{T_1}\;} T_2 = {\overline{C_1}\;} {\overline{C_3}\;} C_5 \cdots C_{2g+1}$ and $D_{2i-1} = C_{2i-1} C_{2i-1}$ $(1 \leq i \leq g+1)$ are elements of $G_g$, $C_1^{\pm 1} C_3^{\pm 1} \cdots C_{2g+1}^{\pm 1}$ is an elements of $G_g$ for any choice of $\pm 1$’s. Let $[[\epsilon_1, \epsilon_2, \ldots, \epsilon_{2g+2}]]$ be the 0-1 sequence corresponding to $[i_1, i_2, \ldots, i_r]$. We define $\gamma_i$ $(1 \leq i \leq g+1)$ as follows: $\gamma_i = +1$ if $(\epsilon_{2i-1}, \epsilon_{2i}) = (0,0), (0,1)$, or $(1,1)$, and $\gamma_i = -1$ if $(\epsilon_{2i-1}, \epsilon_{2i}) = (1,0)$. Then $(C_1^{\gamma_1} C_3^{\gamma_2} \cdots C_{2g+1}^{\gamma_{g+1}})
*[i_1,\ldots,i_r]$ is the reversion of $[i_1, \ldots, i_r]$.

By (2) ofand public official Harris Weinstock.

Other initial club members included Bank of America founder A. P. Giannini, architect Bernard Maybeck, U.S. President Herbert Hoover, Bechtel Corporation founder W. A. Bechtel, members of the Haas family who headed Levi Strauss, Inc., U.S. Senator James Phelan, San Francisco Mayor and California Governor James "Sunny Jim" Rolph, Matson Navigation founder William P. Roth, Stanford University president and U.S. Secretary of the Interior Ray Lyman Wilbur, M.D., Bank of California/Union Bank founder William Chapman Ralston, Crown Zellerbach founder J. C. Zellerbach, department store founder Joseph Magnin, California Governor J. N. Gillette, Italian Swiss Colony winery founder Carlo Rossi, and Isaias Hellman, prominent West Coast financier and first president of Wells Fargo Bank. Their goal was cooperation on civic betterment in spite of political


The safety and effectiveness of newer antiepileptics: a comparative postmarketing cohort study.
Clinical trials for the newer antiepileptic drugs (AEDs) have provided inconclusive information to evaluate comparative risk benefit. The authors use data from postmarketing observational cohort studies to compare the failure of treatment with lamotrigine, vigabatrin, and gabapentin in patients with refractory epilepsy. The Drug Safety Research Unit has conducted prescription event monitoring (PEM) studies for lamotrigine, vigabatrin, and gabapentin to monitor their safety when used in primary care. The primary outcome of this study was time to treatment failure in patients who had been prescribed the drug after the start of the PEM study. Patients on gabapentin had reduced time to treatment failure compared to those on the other 2 drugs. The age- and sex-adjusted hazard ratiobetween *C. difficile* strains and to *E. faecalis* [@bib45].

6. The *skin*^Cd^ element {#sec6}
=========================

The [s]{.ul}ig[K]{.ul} [i]{.ul}nterve[n]{.ul}ing sequence (skin) element was originally identified as a prophage-like sequence integrated into the *B. subtilis sigK* gene [@bib46]. When *B. subtilis* sporulates, the element excises only in the mother cell, resulting in an intact *sigK* gene and production of the sigma factor K which is required for the sporulation cascade. *C. difficile* also contains a skin element, skin^Cd^ integrated into the *sigK* gene [@bib38]. In common with *B. subtilis,* excision of this element in the mother cell is required for sporulation [@bib38]. In contrast to *B. subtilis,* however, *C. difficile* strains that do not contain the skin element sporulate very poorly. Skin^Cd^ is much smaller than the *B. subtilis* skin element at 14 kb


snips and indels that differentiate the 630 donor genome from the CD37 recipient genome; the dark blue fragments on the third circle represents the location of CTns the red fragment on the third circle represent the location of the PaLoc, the purple fragments on the third circle represent the location of prophage. The fourth to the tenth circle represent CD37 transconjugants containing the PaLoc, transferred fragments are shown by coloured lines, transferred CTns and PaLocs are shown. The right hand panel shows the region containing the PaLoc in more detail. (for more details see reference [@bib47]). Figure reproduced from; Brouwer MS, Roberts AP, Hussain H, Williams RJ, Allan E, Mullany P. (2013). Horizontal gene transfer converts non-toxigenic *Clostridium difficile* strains into toxin producers. Nature Communications. 4, 2601.](gr2){#fig2}
Published by Game Design, in the same Decatur IL building Judges Guild started at in 1976! Detailing Judges Guild & his time with Bob Bledsaw, a History by Judges Guild co-founder, Bill Owen.... More > Main items -- Background of Bill Owen as an early wargamer in the 1960's and early 1970's -- Meeting Bob Bledsaw, our D&D campaign days -- The false start with the forgotten roleplaying game system that was "out of this world" -- Personal pictures and scans of one-of-a-kind play aids -- Our wild ride on the Judges Guild tiger particularly my part from 1976-1978 -- Difficulties, goofs and cautions for other gamer/entrepreneurs -- My time with Bob after JG & our favorite games -- Bringing it up to date. Details: 36 pages, 16,842


words, 34 black & white photos or scans, 86 full color or duotone photos or scans from 1965-2008 many never seen before publicly, some from Bob Bledaw Jr. and the JG archive.< Less

Published by Game Design, in the same Decatur IL building Judges Guild started at in 1976! Detailing Judges Guild & his time with Bob Bledsaw, a History by Judges Guild co-founder, Bill Owen.... More > Main items -- Background of Bill Owen as an early wargamer in the 1960's and early 1970's -- Meeting Bob Bledsaw, our D&D campaign days -- The false start with the forgotten roleplaying game system that was "out of this world" -- Personal pictures and scans of one-of-a-kind play aids -- Our wild ride on the Judges Guild tiger particularly myfor being there.
This product was written by Bob Bledsaw for use with the Judges Guild Universal System, and contains the latest version of charts to date. Happy Gaming!< Less

Lost Man's Trail (2010) JG1290
Bob Bledsaw's final contribution to the fantasy world he created, the Wilderlands. This adventure module runs some 24 pages, with 12 maps covering the areas of... More > encounters, in addition to detailed Campaign Maps for Wilderlands Hexes 3615, 3715, 3814 and 3914 of the Roglaroon and Gasconfold Plains Regions, between Modron and Tegel.
The trail east from Modron to the Coast, known as Lost Man's Trail, has been a source of mystery for some time. Adventurers have a habit of disappearing from the trail. Are they lured away by some enticement, or waylayed by the legendary


of the device and is provided with a specific timing control portion for assuring synchronous operations of the control units.
The technical content of the above Publication consists in that image-processing portion for conducting processing of an image according to image data from an image forming portion is constructed as a single control unit.
To supply a variety of the digital copying machines, it is therefore necessary to prepare specific control boards depending upon the specifications of the goods. This may burden users with an increased initial cost of the goods and manufactures with time and cost of development. The need for additional control for synchronizing the respective processing portions is also a problem in costs.
Accordingly, the present invention is directed to a variety of digital copying machines from anfloored me.

It all started to make sense.

It was Cancun, Mexico—some cheesy resort hotel in March, 1999. I was sitting by the pool with some USC friends. College had officially ended the year before and yet here I was, still clinging to some spring break fantasy.

Maybe not as much clinging… but hiding. I had written the script for Donnie Darko the previous summer and by December I had somehow hit the jackpot: Creative Artists Agency was representing me… and I was still a fetus.

I had been meeting all sorts of fancy industry people. They were reading my script—mostly telling me they thought it was a terrific and very ambitious writing sample—but most likely un-producible. They certainly didn’t believe that I was capable of directing it. The consensus was that


it is much more fun to think of Alice with her dream and Bill with his reality.

Stanley Kubrick has a long history of satirizing the patriarchal power elite with dubious portrayals of government agencies bent on achieving good old-fashioned imperialism (Paths of Glory), Armageddon (Dr. Strangelove), interstellar imperialism (2001: A Space Odyssey), psychological conditioning (A Clockwork Orange), and finally: catastrophically botched imperialism (Full Metal Jacket).

Kubrick gave us a satirical portrait of sexual obsession in Lolita, wherein two men (James Mason and Peter Sellers) corrupt and destroy the lives of two women (Shelley Winters and Sue Lyons).

With Barry Lyndon, he gave us one of the all-time great portrayals of a sociopath (played by Ryan O’Neal) who destroys everyone and everything around him in his quest to be part ofin which Amy’s act of revenge disappearance is slowly digested by Nick, Margo and two detectives (Kim Dickens and Patrick Fugit) through a series of clues left behind on their fifth wedding anniversary.

Nick, of course, becomes the prime suspect.

The town, of course, sees the missing Amy as some kind of saint—and the arrival of the media galvanizes the community in a way that is all too real.

There is an incredibly revelatory sequence in Gone Girl where the entire town has gathered at a hotel ballroom that has been transformed into an Amazing Amy search command center. Even the mayor is there—wearing an orange vest—no doubt looking for a chance to be on camera.

A group of single and divorced-looking women—several of whom look like they might have prison pen


you can show off how fearless and fierce you are on the battlefield when you enter the party scene this year with some awesome weaponry. Accessories this noble look with a mighty battle-axe or a trusty bow-n-arrow combo. Also, don’t forget to grab some footwear that matches the rest of this striking outfit. Then you can even grab one of our amazing Indian Headdresses to top of your new exotic look. Grab a handful of friends and you can all go out as an army of your tribe’s finest warriors. You’ll be ready to fight off all the buzz-kills at any party and ensure an epic Halloween celebration for everyone!

So if you’re ready to go out this year as a perfect blend of elegant and exciting then thissick. Logic, right? She wasn't sick before, she took a drug that made her sick. Oh... dear, how fast their leaps of logic, how twisted this story will become.
When they diagnosed this disease, Dermatomyositis, no one had ever connected it with the drug Lisinopril. Mainly the cause of this illness is CANCER. So, instead of looking further into the connection with the drug, the doctors began to look for cancer. My mother got cat scans, pet scans, hydoscans, poked, prodded, pestered in the desperate search for the BIG C. Except they couldn't exactly find it. No, that's not accurate, they couldn't find it at all. What they did find is two nodules in her lung that were "suspicious". They decided to presume they might be cancer. But they


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 * contributor license agreements.  See the NOTICE file distributed with
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 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
Thinking About Acquisition? Think About Branding

Bringing in a CFO to “clean up the books” before acquisition is a common process. Even if the books aren’t particularly dirty to begin with, a good CFO has the ability to help cast the company in the best possible financial light to potential investors. The fact that CFOs can make or break an acquisition isn’t news1, and any CEO worth their salt would recognize their importance in the process. What many worthwhile CEOs might miss is the fact that good branding can be equally important in an acquisition.

By Michael Schaffer

March 26, 2015

Bringing in a CFO to “clean up the books” before acquisition is a common process. Even if the books aren’t particularly dirty to begin with, a good CFO has the ability


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MEDIA ADVISORY
AUGUST 2, 2010 #10-034
10:00 A.M. DONALDSON

Alexandria Police Roaming DWI Enforcement Results

Alexandria police conducted a roaming DWI enforcement effort to deter and apprehend intoxicated drivers from 10:00 P.M. on Friday, July 30, to 6:00 A.M. on Saturday, July 31. Vehicles observed committing traffic infractions were stopped and drivers were checked to assure that their abilities to drive had not been impaired by alcohol or drugs.

During the roaming enforcement effort, thirty vehicles were stopped and one arrest was made for Driving While Intoxicated (DWI). Twenty-three summonses were issued for miscellaneous traffic offenses and eight traffic violation warnings were given. <item name="android:background">@drawable/action_bar_tab_indicator_1</item>

    <!-- Support library compatibility -->
    <item name="background">@drawable/action_bar_tab_indicator_1</item>
</style>

<style name="NoTitleText">
    <item name="android:textSize">0sp</item>
    <item name="android:textColor">#00000000</item>
    <!-- Support library compatibility -->

</style>

<style name = "NewTitle" >
    <item name="android:textSize">20sp</item>
    <item name="android:textColor">#ffff</item>

</style>

<style name="BasicTheme" parent="Theme.AppCompat.Light.DarkActionBar">
    <item name="actionBarSize">50dp</item>

</style>
</resources>

And finally this is my Gradle Script, this is where I think, the error must be, I personally work with an minSdkVersion 9, this way I cover most of the android OS from 2.3 to 5.
build.gradle app
apply plugin: 'com.android.application'

android {
compileSdkVersion 22
buildToolsVersion "22.0.1"

defaultConfig {
    applicationId "com.prometheus.projectz.projectz"
    minSdkVersion 9
    targetSdkVersion 22
    versionCode 1
    versionName "1.0"
}
buildTypes {
    release


Antibody-drug conjugates: an emerging concept in cancer therapy.
Traditional cancer chemotherapy is often accompanied by systemic toxicity to the patient. Monoclonal antibodies against antigens on cancer cells offer an alternative tumor-selective treatment approach. However, most monoclonal antibodies are not sufficiently potent to be therapeutically active on their own. Antibody-drug conjugates (ADCs) use antibodies to deliver a potent cytotoxic compound selectively to tumor cells, thus improving the therapeutic index of chemotherapeutic agents. The recent approval of two ADCs, brentuximab vedotin and ado-trastuzumab emtansine, for cancer treatment has spurred tremendous research interest in this field. This Review touches upon the early efforts in the field, and describes how the lessons learned from the first-generation ADCs have led to improvements in every aspect of this technology, i.e., the antibody, the cytotoxic compound,Senator Aquilino "Koko" Pimentel III

MANILA - Senator Aquilino "Koko" Pimentel III expects Filipinos to start enjoying lower taxes by 2018, as legislation for reforms are now pending.

"The sponsors were ready in the 16th Congress except that the Executive branch was not enthusiastic about the measure. But now tax reform has been, was promised by President Duterte and Congress is ready," Pimentel said at the sidelines of the 112th anniversary of the Bureau of Internal Revenue (BIR).

Pimentel was a special guest at the event, along with Finance Secretary Carlos Dominguez.

In his speech, Dominguez tougher news for the agency, saying he is not in favor of raising value added tax (VAT) rates to compensate for lost revenues due to tax reform.

"By some estimates we could double VAT collections simply by