Romania
Category:FC UTA Arad players
Category:FC Politehnica Timișoara players
Category:FC Steaua București players
Category:Liga I players
Category:Romanian football managers
Category:SC Telstar managers
Category:Sparta Rotterdam managers
Category:FC Dordrecht managers
Category:Go Ahead Eagles managers
Category:Eredivisie managers
Category:Romanian expatriate football managers
Category:Expatriate football managers in the Netherlands7.15.2010

Hey Glamazons! So, unless you've been hiding underneath a rock these past couple of weeks, I'm sure you've heard all about the fact that MAC hooked up with Alice + Olivia creator Stacey Bendet to create their newest collection . It's fun, flirty and consists of MAC's Dazzleglass Creme lipgloss, Pigment and Nail Lacquer. What's even more fun than playing with the products in the collection? Why, chatting with the designer herself! (That's us pictured together! Isn't she the cutest?! She agreed with me when I said we were very attractive lol) Last night was the official launch party and models along with the media elite gathered at The Beauty Bar to celebrate. Here's what Stacey had to say about the collabo:

Ferocia: Why did you decide to the


collection with MAC?

Stacey: MAC has always been one of my favorite brands, just from the purpose of their makeup. I'm like obsessed with all of it and I'm always running to the makeup counters. They always have the most fun colors and, I don't know, I just feel like that's sort of like who my girl is. And, it's not that I don't try a million different makeups because I'm a big collector but, I just love how they do all of their branding. I've always loved how they do their collaborations. So, when they approached me to do something I was really excited because I felt like MAC and Alice + Olivia have a lot of sort of synergies. And it was great. It was so fun!

Ferocia:from KP (plus 32" circs in 0, 1 and 3), so I know how great they are. Things are really tight financially, so it'll probably be a while before I can do a whole set. Maybe after Christmas.

Trust me, I KNOW they are the best. ;)

I thought about selling my Boyes, but I think I'll save them for when I have multiple projects on the same size.

fluffypechey

09-27-2006, 09:59 AM

:?? I have no idea what this magic loop is. Can someone please please show me what it is???? Please.

It sounds like fun, I wonder if we have them here?

Is there a video I can watch to do the 2 circular thingy? That sounds like fun. I have a new circular waiting to be used!! :happydance:

browniscoat I would love to


12" and 16" circs on smaller diameter knitting like hats when one circ is all that I need!

Hildegard_von_Knittin

09-27-2006, 12:56 PM

I like the 2 circs method, too. I have 2 circs in several sizes (i've never used my denise or boye for 2 circ knitting), and at forst I kep knitting witht he wrong ends too. I just took a permenant marker and colored both tips on one needle, so I knew immediately if I was knitting with the wrong end, because one tip would be green and the other plain.

Julie--can you do 2 socks on 2 circs at once and knit from both ends of the same ball, or do you have to use 2 different balls?

Friskums

09-27-2006, 01:19 PM

I bought one set of Denise's at regular price, andthan 2 circs, because the yarn gets tangled in the extra circ also.

I used this pattern for the socks, Two At Once, Toe-Up Sock Pattern (https://www.knitpicks.com/Projects/Projects_Display_Yarn.aspx?itemid=50417220) and I used the Turkish Cast-on, here (http://fluffyknitterdeb.blogspot.com/2005/10/knitting-made-easier-turkish-cast-on.html). The sock pattern is for 2 circs, but I adapted it to Magic Loop. I had to experiment with the Turkish cast-on to get it to work, but if you do the wraps for both socks first, and then start the knitting part it works out. It helps to practice first.

There are pictures on my Flickr that show how the socks were on the needles, but they are not all together. I guess I should do some tags or something.


in China. In this real‐world study, we sought to describe the survival of lymphoma in our academic center, and evaluate the temporal trend over two decades.

2. PATIENTS AND METHODS {#cam43037-sec-0006}
=======================

This retrospective study was approved by the Ethics Committee at Peking University Cancer Hospital and Institute, in accordance with the Declaration of Helsinki; and the requirement for informed consent was waived because of the anonymous nature of the data.

A total of 3840 patients with de novo lymphoma diagnosed from January 1, 1996 to December 31, 2015 were retrospectively collected. Eighty patients were excluded from the study for the following reasons: unclassified pathological type (n = 24), incomplete clinical data (n = 16), and only best supportive care (n = 40). Finally, 3760 patients were analyzed in this study. The clinical and histological data of theseof 1.4:1. The median age of the whole cohort was 52.3 (range, 7.3‐92.7) years, and there was an increase in the median age from 1996‐2000 to 2011‐2015 (*P* = .038). Of the whole cohort, 87.0% had NHL, and 13.0% had HL. A higher proportion of NHL was observed in 2001‐2005. There were 61.8% of patients at advanced stage (stage 3‐4) and 38.2% at early stage (stage 1‐2). An increase in proportions of early‐stage patients was observed from 1996‐2000 to 2011‐2015.

######

Baseline characteristics of 3760 patients with lymphoma

  Characteristics   Number (%)         *P* value


Scanner dictionarytemp = new Scanner(diction) ;

     while(dictionary.hasNextLine()) {

         if((char)incre != ((dictionarytemp.nextLine()).charAt(0)))  {
            alpha_list.close();
            incre++ ;
            alpha_list = new PrintWriter("C:/Users/LoRd CuRZon/Desktop/dictionary/" + (char)incre + ".txt" ) ;
         }

     alpha_list.println(dictionary.nextLine());

      }

      alpha_list.close();
      dictionary.close();
   }

 }

A:

It is you second nextLine() that is causing the problem. It moves to the nextpoints of the story. Napoleon represents Julien's ambition in the serial, he compares himself with the French hero, seeing himself as an extraordinary individual.

Cast
 Ewan McGregor - Julien Sorel
 Martin Jarvis - Monsieur de Rênal
 Alice Krige - Madame de Rênal
 Rachel Weisz - Mathilde de la Mole
 T. P. McKenna - Marquis de la Mole
 Jo Ross - Marquise de la Mole
 Stratford Johns - Abbé Pirard
 Clive Arrindel - Abbé de Frilair
 Christopher Fulford - Napoleon
 Michael Attwell - Monsieur Valenod
 Crispin Bonham-Carter - Comte de Croisenois
 Georges Corraface - Comte Altamira
 Edward Atterton - Comte de Beauvoisis
 Helen FitzGerald - Madame de Fervaques
 Jeremy Young - Duke of Wellington

Episodes

Episode one
In the provincial town of Verrières, Julien Sorel (Ewan McGregor) a carpenter's son who is destined


/**
* Copyright 2012-2020, Plotly, Inc.
* All rights reserved.
*
* This source code is licensed under the MIT license found in the
* LICENSE file in the root directory of this source tree.
*/

'use strict';

var extendFlat = require('../../lib').extendFlat;
var OHLCattrs = require('../ohlc/attributes');
var boxAttrs = require('../box/attributes');

function directionAttrs(lineColorDefault) {
    return {
        line: {
            color: extendFlat({}, boxAttrs.line.color, {dflt: lineColorDefault}),
            width: boxAttrs.line.width,
            editType: 'style'
        },

        fillcolor: boxAttrs.fillcolor,
        editType: 'style'
    };
}

module.exportsBadass Hawking

I had a pleasure to meet this man when I was a physics postdoc at the Max Planck Institute in Munich. He was still able to have lunch with the faculty and gave his own talk through a translator who could understand his deteriorating speech.


the LPP evoked by each picture category was our measure of incentive salience. We calculated the LPP for each picture category for each participant by averaging the voltage recorded between 400 and 800 ms after picture onset from 10 central and parietal sensors (EGI HydroCel Geodesic Sensor Net sensors: 7, 31, 37, 54, 55, 79, 80, 87, 106, 129; see Figure [1](#psyp13309-fig-0001){ref-type="fig"} inset). This group of sensors, also used in our previous studies (Minnix et al., [2013](#psyp13309-bib-0051){ref-type="ref"}; Versace et al., [2016](#psyp13309-bib-0074){ref-type="ref"}, [2012](#psyp13309-bib-0075){ref-type="ref"}), covers the area where the LPP amplitude differences between neutral and emotional pictures is maximal. A preliminary analysis aimed at confirming that the amplitude of the LPP increased as a function of the emotional arousal of the stimuli.

![ERPs from centroparietal sites (see inset for electrode location) showsignificant after applying Bonferroni correction (*p = *0.15). The two groups also had similar demographic characteristics and level of hunger at the beginning of the experiment (Table [1](#psyp13309-tbl-0001){ref-type="table"}). The pattern of results and the proportion of individuals assigned to the two clusters were similar regardless of whether sweet or savory contents predicted food delivery. In summary, these results indicate that, although every participant was aware that food‐paired stimuli predicted food delivery, some individuals (C \> P) attributed more incentive salience to food‐paired images than to erotic images, while others (P \> C) processed food‐paired stimuli as though they had low incentive salience.

![Left: The *k*‐means cluster analysis performed on the LPP responses yielded two clusters fitting with the hypothesized dichotomy. Some individuals (C \> P, *N = *20) reacted more to Food+ images than to erotic images (*p \< *0.0001), while


assault to law enforcement, allowed the aide to leave the scene to go home for the night, failed to notify the victim’s family of the assault, and compromised critical evidence. This is just one example of a problem affecting seniors across the country.

The preliminary conclusions of an ongoing national review by the HHS Office of Inspector General (OIG) have also found “inadequate procedures” at the Centers for Medicare and Medicaid Services (CMS) for identifying and reporting potential incidents of abuse or neglect in nursing home facilities. OIG has recommended that CMS take immediate action to strengthen its procedures and the enforcement of existing requirements.

To identify additional measures that HHS can take to prevent and more effectively respond to elder abuse in nursing homes and assisted-living facilities, I respectfullyfull-length gene models [@pcbi.1003998-Parra2]. This method has been used by the Assemblathon [@pcbi.1003998-Bradnam1] as one measure of the quality of different genome assemblies. [Table 2](#pcbi-1003998-t002){ref-type="table"} reports the completeness of CEGMA genes in each of the chicken assemblies analyzed here. The most up-to-date assembly (v4.0) shows the highest percentage of full-length CEGMA genes (80.7%), while the fosmid-only assembly shows the lowest (14.1%). As the average gene length in the current chicken annotation is 27.8 kb, it is clear that many genes have large pieces missing or are fragmented onto multiple contigs in these assemblies.

10.1371/journal.pcbi.1003998.t002

###### Number of predicted genes in simulated *D. melanogaster* assemblies.

![](pcbi.1003998.t002){#pcbi-1003998-t002-2}

                         Number of


correct), which will lead to incorrect inferences about rates of gene family evolution, and false inferences of specific gene gains and losses.

Examining the cause of errors in a draft chimpanzee genome {#s2b}
----------------------------------------------------------

We performed a similar analysis on the chimpanzee genome, comparing the original chimpanzee annotation (Pan_troglodytes-1.0) with an updated version of the same genome (Pan_troglodytes-2.1). This analysis differs from the chicken analysis in that we relied solely on the published annotations, and therefore improvements to the predicted gene set may be due to improvements to the assembly, improvements to the *ab initio* gene predictors, and/or additional functional data. However, this analysis also removes the gene-prediction step from our hands, allowing us to evaluate predictions done by the Ensembl pipeline on two different assemblies.

We find a similar result inand therefore for inflated gene numbers to be reduced. While gene models from related species offer an alternative method for identifying fragmented genes [@pcbi.1003998-Stark1], RNA-seq can be used for any species, regardless of whether there is a genome with a high-quality annotation that is closely related.

To determine the effectiveness of RNA-seq data in restoring fragmented gene models we obtained reads from 11 published experiments in *D. melanogaster* ([Table 2](#pcbi-1003998-t002){ref-type="table"}). After mapping paired-end reads from these experiments back to our simulated assembly with 17,941 contigs, we asked whether there were any cases in which two different predicted gene models were uniquely hit by a connected pair of reads. In other words, we looked for pairs of reads for which one hit one predicted gene and the other read hit


contigs may result in the over-prediction of genes. We therefore chose 50 bp as a minimum cutoff length for the length of gaps, separating scaffolds into individual contigs when stretches of N\'s longer than fifty characters were found. Applying this cutoff to the *Daphnia pulex* assembly revealed 17,924 "contigs" useful for gene prediction.

*Drosophila melanogaster* assembly release 5.44 was obtained from Flybase [@pcbi.1003998-Marygold1], in the form of six chromosome files. Using the distribution of contig sizes found in the *Daphnia pulex* assembly, we generated 10 simulated *D. melanogaster* assemblies with different numbers of contigs ([Table 4](#pcbi-1003998-t004){ref-type="table"}). To do this, for any specified number, *x*, of contigs needed for the simulated *D. melanogaster* genome we took the longest *x* contigs from the *Daphnia pulex* assembly. The reference *D. melanogaster* genomeartificially created text and graphics, hereinafter named line work data as well as halftone presentations of continuous tone images, hereinafter named raster images. Consequently, the amount of data required for printing each line of the final image will vary depending upon the nature of the image. Usually a block of data, representing for example a whole page of printed images, is received and stored in an intermediate buffer before printing begins, so that the data may be released from the buffer at the speed required by the printing station.
In order to store as much data as possible, and in order to keep the bandwidth and capacity requirements of the image data storage and processing equipment to a minimum, it is known to compress the data while or after


data in electronic printing. This is especially true for raster images because the information that is lost may have been difficult to be seen by the human eye anyway, for example because it was of a too high spatial frequency. Lossy compression, e.g. as implemented by the JPEG method, is however often unacceptable when being applied to line work elements in electronic printing.
A known method to overcome the above dilemma consists of separating the line work elements of the image data from the raster images, and compressing each of said elements using a different method, e.g. lossless LZW for line work elements and lossy JPEG for raster images.
It is well known that state-of-the-art lossless compression methods result in compression ratios that are dependent on the actual data onwhose baby was delivered prematurely and later died.

In earlier overnight swoops in the West Bank, Israel also said on Thursday its commandos had killed the Palestinian behind Sunday’s attack, as well as another wanted for an Oct 7 shooting at a settlement industrial park that killed a man and a woman, both civilians.

The West Bank, Gaza Strip and East Jerusalem were captured by Israel in a 1967 war. Palestinians hope to establish a state in the three territories.

The West Bank is under Israeli military occupation, with the Palestinian Authority exercising limited self-rule. Israel has withdrawn its settlers and soldiers from Gaza but maintains a blockade on the coastal strip, which is now controlled by the armed Islamist group Hamas.

In two other incidents on Thursday, police said a Palestinian


similar.

I shouldn't of been a dick and said sell the vehicle, I think I have been on these forums a bit too long (see below).

These cars are very expensive to fix and maintain, I came from other car forums including Corvette forum, Fiero forum (I have a 355 Spyder kitcar), and the DSM forum (I had a high 10's Talon TSI) and am respected for my information on those forums, but I still cant get my head around some of the negative posts on this forum.

I would have never chirp people for asking a silly questions, asking a question that has been answered a million times, or spelling errors, but for some reason behind a screen gives people permission to be real dicks and I guess I haveplatelet count of 169,000 /μL, a serum creatinine level of 0.97 mg/dL, a creatinine kinase-MB level of 2.78 ng/mL (within the normal range), a troponin I level of 0.449 ng/mL, and a D-dimer level of \>5,000 ng/mL. We carried out echocardiography, which revealed a 60% left ventricular ejection fraction, a moderated tricuspid regurgitation, and a systolic pulmonary artery pressure of 70 mmHg, with an enlarged right ventricle. The interventricular septum was semi-paradoxical, and the right ventricular free wall was hypokinetic. A 7×1.5 cm, free-floating giant thrombus was seen extending from the inferior vena cava to the right atrium and right ventricle ([Fig. 1](#f1-ceem-16-198){ref-type="fig"}). A mobile thrombus was also seen in the proximal right pulmonary artery. We diagnosed acute, high-risk pulmonary embolism. The patient underwent emergency surgical thrombectomy, and


not contested the succession be considered a "litigant" or the succession proceeding, which in most instances is not a contradictory proceeding, be deemed to be a "pending lawsuit"? Section 3865 of the statute requires notice to be served on all the "parties to the suit;" sections 3866 and 3868 deal with payment of a judgment by the "litigant cast." There is no "litigant" in this succession proceeding.
In addition, counsel for The National Bank of Commerce in New Orleans has pointed out to the court that LSA-R.S. 13:3864-3868 have as their source Louisiana Act No. 85 of 1928 and that, since the adoption of that Act, many cases have passed on the seizure of the interest of an heir in a succession and not one has required the procedurein order for the seizing creditor to perfect a privilege. LSA-C.C.P. art. 2292 provides:
"The seizing creditor, by the mere act of seizure, acquires a privilege on the property seized, which entitles him to a preference over ordinary creditors.
"When several seizures of the same property are made by ordinary creditors, the seizing creditors acquire a privilege and are entitled to a preference among themselves according to the order of their seizures." (Emphasis added.)
In Succession of Hoffman, La.App., 141 So.2d 505 (4th Cir. 1962), the plaintiff-inrule contended that the seizure made under article 2292 of the Code of Civil Procedure was null because he had received no notice. In answering this contention this court held:
"A cursory analysis of the jurisprudence reveals that the foregoing contention is without merit. As was


enunciated in the ancient case of Walker v. Creevy4 [6 La.Ann. 535] wherein Walker seized a judgment payable to Creevy without the issuance of a notice to him, in connection with a garnishment proceeding, the organ of the court reasoned thusly:
"`We find no law rendering it necessary that notice should have been given of the seizure to Creevy. If the sheriff had been directed to sell the claim, it would have been necessary to have given notice to Creevy, that he might appoint an appraiser. But having seized an incorporeal right, the proper and legal mode of realizing it, was to cause it to be collected. * * *'"
"In the more recent case of Chalmette Petroleum Corporation v. Myrtle Grove Syrup Co.5 [175 La. 969, 144 So. 730](not shown) arranged therein and a bus support conductor 27 for carrying the bus. Main circuit disconnecting devices 30 are mounted on the partition plate 16 opposite to output terminals of the circuit breaker 12. A power source side terminal of one main circuit disconnecting device 30 is connected to the bus support member 27 and an output side terminal of the other main circuit disconnecting device 30 is connected to a load cable 34 through a connecting conductor 32. Only electrical connections for one of the three phases are illustrated. The door 36 which can be opened/closed is arranged in front of the circuit breaker compartment 18, and a door 35 which can be opened/closed is arranged in front of the control line compartment 24. A ceiling


plate 40 is disposed at a ceiling section, and a detachable cover 42 is arranged behind the cable compartment 20. A floor plate 44 is mounted below the closed box 14. A guide plate 46 is mounted on the floor plate 44 to guide the circuit breaker 12 upon insertion/removal thereof with respect to the closed box 14.
FIG. 2 shows a metalclad switchgear wherein circuit breakers and their cooperating equipment are housed in two stages in a single closed box 15. The metalclad switchgear of FIG. 2 is substantially the same as the structure obtained by vertically stacking two metalclad switchgears of FIG. 1 except that control line compartments 24a and 24b are arranged in front of circuit breaker compartments 18a and 18b to decrease the height ofdependency on Hamiltonian - we can proceed no further without specifying the particular form of $H$, and so of $\langle x'' | 0 \rangle$. Of course, for simplicity we begin with the harmonic oscillator.
$$\langle x | 0 \rangle = \pi^{-1/4} \operatorname{e}^{-x^2/2}$$
Where I chose $\dfrac{m \omega}{\hbar} = 1$ for convenience. Hence, one gets:
$$\pi^{-1/4}\int \operatorname{d}x''\langle x'| \hat{\mathcal{O}} |x''\rangle  \operatorname{e}^{-(x'')^2/2} =\delta(x-x')\\
$$
Can anyone help me to find $\langle x'| \hat{\mathcal{O}} |x''\rangle  $? For sure, I don't expect $\hat{\mathcal{O}}$ to be a 'nice' operator, since it does not define a properly normalised state. I expect it to be some kind of distribution, whose kernel I would like to know.
UPDATE 1
Few clarifications about the statement of the question:

The question is about a $1$-d QM problem, with a single degree of freedom. In


launch is scheduled for May 26, 2012. We wouldn’t mind repeating and exceeding that carefully planned engineering process known as sheer luck. But, having temporarily satisfied our thirst for altitude, this time we will focus on experimentation.

Central-southern Italy, with lakes Trasimeno and Bolsena at right. The view faces south. Panorama created with StratoSpera 3 photos by Francesco Bonomi.

We will use a cluster of three balloons, rather than a single one, to evaluate its ability to stabilize the payload. This would be useful, for example, for imaging in low lighting conditions. A wide field mini camera mounted in the upper section of the gondola facing upwards, code-named Polifemo (Polyphemus), will image the balloons to help study their dynamics. It will complement the set of environmental and engineering sensors (temperature,to $10^5\,$K or about $25\,$eV per atom.

Massive stars will deposit both radiative and mechanical energy into the interstellar medium of subgalactic fragments. A complex network of ‘feedback’ mechanisms is likely at work in these systems, as the gas in shallow potential is more easily blown away thereby quenching further star formation, and the blastwaves produced by supernova explosions reheat the surrounding intergalactic gas and enrich it with newly formed heavy elements and dust. It is therefore unclear at this stage whether an early input of mechanical energy will actually play a major role in determining the thermal and ionization state of the IGM on large scales (Tegmark [et al. ]{}1993). What can be easily shown is that, during the evolution of a a ‘typical’ stellar population, more energy is lost


escape into the IGM. Consider, in particular, the case of an early generation of halos with circular speed $v_c=25\,\kms$, corresponding in top-hat spherical collapse to a virial temperature $T_v=0.5\mu m_p v_c^2/k\approx 10^{4.3}\,$K and halo mass $M=0.1v_c^3/GH\approx 10^8 [(1+z)/10]^{-3/2}
h^{-1}\, \msun$. In these systems rapid cooling by atomic hydrogen can take place and a significant fraction, $f\Omega_B$, of their total mass may be converted into stars over a dynamical timescale (here $\Omega_B$ is the baryon density parameter). In a flat cosmology with $\Omega_M=1$, $h=0.5$, and rms mass fluctuation normalized at present to $\sigma_8=0.63$ on spheres of $8\,h^{-1}\,$Mpc, halos with $M=10^8\,h^{-1}\,\msun$ would be collapsing at $z=9$ from 2 $\sigma$ fluctuations. At this epoch more massive halos with $M=10^{10}\,h^{-1}\,\msun$, while able to cool rapidly, would be collapsing from 3 $\sigma$ peaks andH is ionized and He is either singly or doubly ionized. As more and more sources of ultraviolet radiation switch on, the ionized volume grows in size while the neutral phase shrinks. Reionization is completed when the regions overlap, and every point in the intergalactic space gets exposed for the first time to a nearly uniform Lyman-continuum (Lyc) background.

In the presence of a population of ionizing sources, the transition from a neutral IGM to one that is almost fully ionized can be statistically described by the evolution with redshift of the volume filling factor (or porosity) $Q$ of , , and regions. The radiation emitted by spatially clustered stellar-like and quasar-like sources – the number densities and luminosities of which may change rapidly as a function of redshift


The detection of a strong [Ly$\alpha\ $]{}emission line in the spectra of bright QSOs shining for $\ga 10^7\,$yr cannot then be used, by itself, as a constraint on the reionization epoch. The first signs of an object radiating prior to the transition from a neutral to an ionized Universe may be best searched for in the spectra of luminous sources with a small escape fraction of Lyman-continuum photons into the IGM, or sources with a short duty cycle.

I would like to thank my collaborators, T. Abel, A. Ferrara, F. Haardt, Z. Haiman, and M. Rees, for many useful discussions on the topics discussed here.

Abel, T., Norman, M. L., & Madau, P. 1999, , 523, 66

Cen, R., & Haiman, Z. 2000, , in press

Cen, R., Miralda-Escudé, J., Ostriker, J. P.,Holter monitor. Only nicardipine significantly decreased the duration (3.2 +/- 1.2 min/h) and the area under the ST time curve (AUC; 5.7 +/- 15.7 AUC/h) of 1-mm or greater myocardial ischemic episodes compared with group C (17.2 +/- 5.6 min/h and 30.1 +/- 49 AUC/h, respectively) during the intraoperative postbypass period. A trend toward lower frequency, duration, and area under the ST time curve of myocardial ischemic episodes was observed in group NIC compared with group NTG. Cardiac indices and mixed venous oxygen saturations were significantly greater, whereas systemic pressures were less in group NIC compared with group NTG for the same period. These results suggest that nicardipine, but not nitroglycerin, decreased the duration and area under the ST time curve of myocardial ischemic episodes shortly after coronary


Q:

Maximum number of elements that can be stored in an array in c

Please pardon me if it is a copy question. I will be happy to delete it if pointed out.
The question is that, if I declare a character array in c, say
char character_array[4];

Does that mean I can only store 3 characters and one '/0' is added as the fourth character? But I have tried it and successfully added four characters into the character array. But when I do that where is the '/0' added since I have already used up the four positions?

A:

Well, yes, you can store any four characters. The string-termination character '\0' is a character just like any other.
But you don't have to store strings, char is a small integer so you can do:
char character_array[]Introduction {#Sec1}
============

Pulsed lasers provide new opportunities for imaging or modulating cellular behavior in a diverse range of diagnostic^[@CR1],[@CR2]^ and therapeutic^[@CR3]^ applications. In particular, virus inactivation through exposure to ultrashort laser pulses is emerging as a potential alternative to existing biocides and ionizing radiation techniques^[@CR4]--[@CR7]^. The current interest in photonic virus inactivation derives from the need for new technologies that achieve a selective inactivation of the pathogens in the presence of other biomolecules or even living cells in food, feed stock in pharmaceutical bioreactors, therapeutic compounds and other sensitive areas with relevance for human and animal health. For many of these applications, harsh chemical or ionizing radiation techniques are not appropriate as they lack sufficient selectivity. Importantly, Kong-Hon Tsen and coworkers have demonstrated in a series of elegant studies


size was approximately 1 cm^2^ and the typical exposure time of the sample to the laser irradiation was 10 sec. All laser irradiation studies were carried out at 22 °C. After irradiation, the samples were immediately stored at 4 °C.

Photoacoustic Measurements {#Sec4}
--------------------------

The acoustic signal generated by laser irradiated nanorods was collected in a homebuilt ultrasound detector. Figure [1](#Fig1){ref-type="fig"} depicts the acoustic wave measurement setup, based on the design of Yelleswarapu and co-workers^[@CR20]--[@CR22]^. The nanorod sample was placed in a 1 mm quartz cuvette, which was located in a custom cell filled with water for ultrasound coupling. The cuvette was oriented at an angle of 45° relative to the 0.3 W fs laser beam. The photoacoustic signal (ultrasonic wave) was collected using a 2.25 MHz focused water immersion transducer.Figure 1Schematic of experimental setup for photoacoustic measurements. The followinggold seed solution was added under thorough stirring. The resulting mix was allowed to age overnight. To obtain PEGylated nanorods, 2.5 µL of 10 mM PEG2 (HS---CH~2~CH~2~---(C~2~H~4~O)~77~---N~3~) were added together with 2.5 µL of 10 mM HS-(CH~2~)~11~-(CH~2~CH~2~O)~6~OCH~2~-COOH to 1 mL of gold nanorods in the presence of 3% v/v of Tween^®^ 20. The samples were incubated overnight and washed by centrifugation and subsequent resuspension. Alkyne-functionalized annexinV was cross-linked to the azide functionalized nanorods in the presence of 500 μM ascorbic acid and 100 μM CuSO~4~ *via* Cu^I^ catalyzed click-reaction^[@CR24]^. The nanorods were cleaned again through repeated centrifugation and resuspension in DDI water or buffer.

Cells and Virus Production {#Sec6}
--------------------------

HEK293T and Rat-2 cells were maintained in DMEM supplemented with heat-inactivated 10% fetal bovine serum (Invitrogen) and Pen/Strep (HyClone). Luciferase expressing, single cycle of replication competent MLV particles


quantification of virus infectivity. In a first set of experiments we tested the hypothesis that nanorods whose LSPR overlaps with the incident fs laser pulse enhances the efficacy of light-induced laser activation. To that end, we compared the viral infectivity obtained with virus particles exposed to fs laser irradiation with constant pulse duration but different average powers. Importantly, we kept the exposure time of the individual samples constant at 10 s, which is 3 orders of magnitude shorter than the exposure time in all previous photonic virus inactivation studies.

Nanorods for Viral Inactivation {#Sec17}
-------------------------------

The LSPRs of gold nanoparticles are strongly morphology dependent, and the aspect ratio of nanorods represents a rational control parameter to tune the plasmon resonance across the visible range of the electromagnetic spectrum to the Near-Infrared (NIR)a ratio of more than 10000:1 in a total volume of 67 μL at 4 °C for up to 12 h. The samples were then diluted by adding 933 μL of PBS, pH 7.4 to a total volume of 1 mL. The final virus concentration was such that infections of Rat2 reporter cells with the luciferase encoding recombinant viruses resulted in approximately 1 × 10^6^ relative light units (RLU). We performed the inactivation studies with PEGylated nanorods as well as with rods functionalized with annexinV that binds to phosphatidylserine (PS) of the enveloped MLV. For the latter, Ca^2+^ was added to the binding buffer when incubating annexinV-functionalized nanorods with virus particles to achieve a final Ca^2+^ concentration of 2 mM.

In many applications it is necessary to inactivate the virus in a complex biological matrix. For instance,


Based on published analyses of threshold intensities in the presence of nanorods^[@CR45]^, we estimate that average powers ≥0.3 W are sufficient to trigger shockwaves under our experimental conditions using pulse durations of 35 fs. We recorded the photoacoustic response of the nanorods, which represent a broad band acoustic emissions followed by a gradual fluctuation that decreased to near zero until another distinct oscillation arrives (Fig. [5b](#Fig5){ref-type="fig"}). Although the temporal resolution of our experiments (our transducer was limited to a frequency of 2.5 MHz) is insufficient to directly resolve shock waves, the successful detection of the acoustic emissions does confirm an efficient transfer of optical energy provided by the incident laser to the resonant nanorods. As the shockwave mechanism is consistent with all experimental observations, we propose it as underlying mechanism of theearly stages of the viral infection rather than on the viral genome or enzymes. LRVs of ≥3.7 were achieved with MLV in as little as 10 s of irradiation. The inactivation was highly specific to the virus while co-incubated IgG antibodies did not show any loss in functionality. The ability to enhance the efficacy of selective photonic virus inactivation with NIR radiation through plasmonic nanoparticles paves the path to a broader applicability of the technique in research and technology.

Electronic supplementary material
=================================

 {#Sec21}

Supplementary Information

**Electronic supplementary material**

**Supplementary information** accompanies this paper at 10.1038/s41598-017-12377-5.

**Publisher\'s note:** Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

We thank Ali Khanezar and Amin Feizpour for insightful discussion. This work was funded in part by the National Institutes of Health R01AI064099


>

    <TextView
        android:layout_width="fill_parent"
        android:layout_height="wrap_content"
        android:text="Your map "
        ></TextView>
</LinearLayout>

kindly tell why i'm getting right side menu blank?

A:

It got worked, problem is. instead of this
 getSlidingMenu().setSecondaryMenu(R.layout.activity_home_frame);

i need to call
getSlidingMenu().setSecondaryMenu(getLayoutInflater().inflate(R.layout.activity_map, null));

growth. This increase in placental function can be accounted for primarily by continual increases in placental (uterine and umbilical) blood flows, associated with increased placental vascularity. Placental vascular growth and development, in turn, are probably regulated by angiogenic factors produced by the placental tissues themselves. These placental angiogenic factors are produced primarily by the maternal placental tissues, are heparin-binding, and seem to be related to the fibroblast growth factor family. Further elucidation of the factors responsible for placental growth and vascular development is critical for an improved understanding of uteroplacental-fetal interactions, which result in delivery of a healthy offspring.


history can be found in [Table 1](#diagnostics-08-00021-t001){ref-type="table"}.

The distribution of pain can be very wide in NTOS, but commonly occurs in the neck, trapezius, shoulder, arm, and in some cases also manifests as chest pain and occipital headache. The pain should be non-radicular in nature and be present during activities, where it may limit function, as well as at rest. Paraesthesias can be widespread in the upper extremity and fingers. Non-specific descriptions include heaviness with movements above the shoulder, referring to the weakness of the affected muscle groups \[[@B7-diagnostics-08-00021]\]. Once this is suspected, history taking may enable one to separate whether the upper or lower parts of the brachial plexus are more involved, with lower plexus (C8-T1) resulting in symptoms in the ulnar forearm and hand, as well asfits with the defensive playstyle.

It is pretty good. Even drawing just two is enough. Is like the ancient prenerf with taunt and 4\6 intsead 5/5. Azur and Kodos is pretty strong and can be used in a lot of decks. In pala murlock you cand draw the three, is a must in that deck. Maybe other combinations can appear but i imagine this card will be important if kodos still beeing good.


demands. But this is also problematic, since it means that the computer systems may reduce the quality of service provided to the users.
Thus, there is a need to reduce the power consumption of sensors used to fulfill requests to measure affective response, and to do so without dramatically reducing the utility of data provided by the sensors.crashed on Akkabarr until last night," Squilyp said, "that is the person you have been."

The Omorr took his time examining me, performing a full-body series of scans before drawing blood samples and testing my physical and mental responses. As he worked, he filled me in on some of the events I'd missed during my extended nap—none of which involved me personally, I noted.

"I can see you being chief medical adviser to the Jorenian Ruling Council," I mentioned as he used a penlight to check my pupils, "but the father of twin boys?"

"My mate claims it was a deliberate attempt on my part to further subjugate her," Squilyp murmured as he used a scope to look at my retinas. "No matter how often I explain that in our species


longer existed; no one did. I hung between the two states, caught in a moment of time and trapped there, unable to go back or forward, helpless to do anything but be in that place.

I could leave it; on some level I knew that, because I had done it before. My body might have been bioengineered to last forever, but it was a thing apart from me. I could shed it like a garment and move beyond this torment. I understood the path and where it would take me. I knew what was waiting beyond it. More of the same suffering and outrage and agony. An eternity of it.

So many things had been done to me during my brief life. So much had been violated, stripped away, andConcepts and strategies for human gene therapy.
Methods of modern molecular genetics have been developed that allow stable transfer and expression of foreign DNA sequences in human and other mammalian somatic cells. It is therefore no surprise that the methods have been applied in attempts to complement genetic defects and correct disease phenotypes. Two decades of research have now led to the first clinically applicable attempts to introduce genetically modified cells into human beings to cure diseases caused at least partially by genetic defects. We discuss here some of the strategies being followed for both in vitro and in vivo application of therapeutic gene transfer and summarize some of the technical and conceptual difficulties associated with somatic-cell gene therapy.


v + 0*2/(-6). Suppose l = 2*g - 1. Is g a multiple of 2?
True
Suppose 3*u = -u + 12. Let n = -4 + u. Does 3 divide (-4)/(-8)*(11 + n)?
False
Suppose 4*z - 16 = 16. Suppose 4*r = z*r - 240. Is r a multiple of 20?
True
Suppose 0*d + 2*d = r - 22, -5*r = -d - 128. Does 13 divide r?
True
Let p be 0 + 3 + (1 - -1). Suppose 5*q = p*l + 55, 2*l - 7*l = 4*q - 80. Does 4 divide q?
False
Suppose 3*j = 2*u + 7, 4*u = 5*j - 6 - 3. Let v = -22 + u. Does 10 divide -1*(-2 + 0) - v?
True
Suppose -4*o - 13 = f, 2*o + 17 = f +80. Is 10 a factor of u?
True
Suppose 0 = 5*f - 113 - 137. Does 6 divide (f/8)/((-1)/(-4))?
False
Suppose -4*t + 16 = -0*t. Let z(j) = -3 + 11*j + 0 - 2. Is z(t) a multiple of 10?
False
Suppose -4*v + 73 = -7. Suppose 0*i + v = 2*i. Is 4 a factor of i?
False
Let v(w) be the second derivative of w**3/6 + 2*w**2 - 3*w. Let


an original message ${\mbox{\boldmath $s$}}^0$ of size $N$ is encoded into a codeword ${\mbox{\boldmath $y$}}_0$ of size $M$ by some encoding device. The aim of this stage is to add redundancy to the original data. Therefore, we necessarily have $M>N$. Based on this redundancy, a proper decoder device should be able to recover the original data even if it were corrupted by noise in the transmission channel. The quantity $R=N/M$ is called the code rate and evaluates the trade-off between redundancy and codeword size. The codeword ${\mbox{\boldmath $y$}}_0$ is then fed into a channel where the bits are subject to noise. The received noisy message ${\mbox{\boldmath $y$}}$ (which is also $M$ dimensional) is then decoded using its redundancy to infer the original $N$ dimensional message ${\mbox{\boldmath $s$}}^0$. Inand calculations are straightforward, giving $$\begin{aligned}
C_{BAC} = H_2 (\gamma_C) - \frac {1+\Omega_C} 2 H_2 (p) - \frac {1-\Omega_C} 2 H_2 (r), \label{capacity}\end{aligned}$$ where $$\begin{aligned}
H_2 (x) & = & - x \log_2 (x) - (1-x) \log_2 (1-x), \\
\gamma_C & = & \frac {1} {1+\Delta_C} = \frac 1 2 \left[ (1-p) (1+\Omega_C) + r (1-\Omega_C) \right], \\
\Delta_C & = & \left[ \frac {r^r (1-r)^{1-r}} {p^p (1-p)^{1-p}} \right]^{1/1-r-p}, \\
\Omega_C & = & \frac {2 \gamma_C - 1 -r + p} {1 -r -p}. \label{omegC}\end{aligned}$$ In the special case $r=p$, the capacity simplifies to $$\begin{aligned}
C_{BSC} = 1 - H_2 (p),\end{aligned}$$ which corresponds to the capacity of the BSC.

Analytical Evaluation {#section5}
=====================

As stated in section II, our goal is to maximize the posterior $P({\mbox{\boldmath $s$}}|{\mbox{\boldmath $y$}})$. Let us define the following Hamiltonian: $$\begin{aligned}
\mathcal{H} ({\mbox{\boldmath


\label{OmegaCTH}\end{aligned}$$ In the same way, by substituting $m=q=1$ in the saddle point equations one can find a consistent solution. However, the ferromagnetic solution cannot be computed analytically, so we proceed numerically by simply checking the integrand of equations (\[qHat\]) and (\[mHat\]). We did that extensively for $K=3$ (we consider only odd values of $K$ for this scheme, and when $K=1$ the present scheme is equivalent to the parity tree case). We found that the integrand diverges so that when $(q,m)\to(1,1)$, we have both $\hat{q}\to\infty$ and $\hat{m}\to\infty$. We also checked higher values of $K$ (up to $K=5$) and did not find any other consistent solution. We conjecture that this result holds for any finite value of $K$. Finally, substituting $m=q=1$, $\hat{m} \to \infty$ and $\hat{q} \to \infty$ into (\[freeEnergy\]),network considered, we provided a theoretical analysis of the typical performance and gave the necessary conditions for obtaining optimal performance. In each case, we were able to derive results similar to the lossy compression results. Finally, in the case of error correcting code, the replica symmetric solution stability [@Almeida1978] was not checked because no replica symmetry breaking is expected on the Nishimori line [@Nishimori2001bis].

This paper discusses only the typical performance of the schemes at the infinite codeword length, however, and does not provide any explicit decoder. Because the present schemes make use of densely connected systems, a formal decoder cannot be implemented as it would require a decoding time which would grow exponentially with the size of the original message. One promising alternative is to use the popular


2003).

      The BIA was within its discretion in denying the November 17, 2008,

motion to reconsider on the ground that the motion failed to identify any error of

fact or law in the BIA’s April 29, 2008, order. See 8 C.F.R. § 1003.2(b)(1).

      We reject Guncoro’s contention that the case should be remanded in light of

Tampubolon v. Holder, 610 F.3d 1056 (9th Cir. 2010). The BIA analyzed

Guncoro’s claims of persecution as an ethnic Chinese Indonesian under the

disfavored group analysis, as set forth in Sael v. Ashcroft, 386 F.3d 922 (9th Cir.

2004), and Guncoro does not now argue–nor did she argue to the agency–that she

experienced any individualized risk due to her Christianity.

      Guncoro contends the BIAdedicated player, as I play on several different servers with multiple characters.

In my previous role as Director of Live Services for SWTOR, my primary responsibilities were to ensure the game servers were live, that player blocking issues were quickly identified and resolved, and to be the main interface between BioWare and our Customer Service organization. Essentially, anything impacting our players fell to me and my team to get resolved.

I’ve been with BioWare/EA and SWTOR for the past six years, where I’ve held a variety of positions, and have always been a very active player with nearly 10,000 hours of gameplay, 28 plus characters and tons of achievements. I love playing the game and participating in all different types of gameplay, with PvP being one of my favorite activities.


   "ticketPattern": "^((Closes|Fixes) ([a-zA-Z]{2,}-)[0-9]+)|^(Refs? [^#])"
  },
  "husky": {
    "hooks": {
      "commit-msg": "node node_modules/commitplease",
      "pre-commit": "grunt lint:newer qunit_fixture"
    }
  }
}
(**C**) Z-scores of the original markers over PC2 and PC3. (**D**) Visual representation of the inter- and intra-patient heterogeneity, that shows how most of the patients present a relative homogeneous activation status of the Tcy. Each core is assigned an activation status ('Active', 'Transition', or 'Exhausted'). The cores are grouped for each patient, giving an at-a-glance representation of the heterogeneity of the activation status in different areas of the melanoma in the same patient. (**E**) The survival analysis in our data set shows a higher overall survival for brisk patients (left) and for patients with high levels of activation (right). Most importantly, the functional definition of activation/exhaustion shows improved prognostic value when compared to the brisk morphological parameter (p.value = 0.075 vs p.value = 0.31 log-rank test).](elife-53008-fig2){#fig2}

We then checked whether the core


pathologist (FMB). The choice of the markers to identify the inflammatory cell populations is based on our previous review focusing on the melanoma microenvironment ([@bib9]). Cells were evaluated for consistent cell phenotype as described in the Materials and methods ([Figure 4---figure supplement 1](#fig4s1){ref-type="fig"}). From the 19 clusters identified, 17 could be associated to specific cell lineages, while the remaining two were discarded. Based on the inclusion criteria described in the methods, 179,304 out of 242,224 cells (74.02%) were included for further analysis. Cell phenotypes were further clustered into functional groups using a set of functional markers. The functional clustering resulted in a total number of 47 functional cell populations ([Figure 4A](#fig4){ref-type="fig"}).

![Distribution of the immune cells' subgroups and significant differences in the morphological and functional TILs categories.\
The percentage of cells forcells in the tissue using neighborhood analysis could represent a better way to investigate this dynamic. In this way, we could identify the most important differences that could explain the transition from an active to an exhausted environment. In active cases, it was possible to identify a stronger spatial association between active Th and active Tcy, while the same association was weaker in transition cases and disappeared in exhausted ones. In general, there was a decrease of interactions between the Th compartment and the active Tcy from active to exhausted cases. This could be explained observing the peculiar interactions with the other cell types in each of the functional states. In active cases, TIM3+ macrophages interacted with CD69+TIM3+ Th, as well as cDC1 expressing TIM3 interacted with TIM3+


  rabbit Mab    28--8         Abcam/Epitomics               [2687878](https://scicrunch.org/resolver/AB_2687878)
  CD1a            1 µg/ml         Rb mAb        EP3622        Abcam/Epitomics               [626957](https://scicrunch.org/resolver/AB_626957)
  CD123           1 µg/ml         mouse IgG2b   NCL-L-CD123   Leica-Microystem/Novocastra   [10555271](https://scicrunch.org/resolver/AB_10555271)
  Phospho-Stat1   1 µg/ml mM ABC at room temperature and alkylated with 100 mM IAA in 50 mM ABC (30 min incubation in dark). Digestion of samples was performed overnight at 37°C using 2 µg of MS grade trypsin. RG surfactant were removed using an acid precipitation with TFA at a final concentration of 0.5% v/v. Samples were then spun down for 10 min at 14,000 x g and supernatants collected for MS analysis. Peptide mixtures were desalted and concentrated using Ziptip μ-C8 pipette tips (Millipore Corp, Bedford, MA). An equal volume of eluted digests was injected at least three times for each sample into Ultimate 3000 RSLCnano (ThermoScientific, Sunnyvale, CA) coupled online with Impact HD UHR-QqToF (Bruker Daltonics, Germany). In details, samples were concentrated onto a pre-column (Dionex, Acclaim PepMap 100


depicted from this type of analysis is always the same: "Active" patients show a better prognosis than "Exhausted" ones. This classification, moreover, is better than that of the "Brisk" classification as the p-value reduces from 0.36 to 0.053. Moreover, as the contingency matrix shows, Brisk and Activation are not the same:

![](elife-53008-resp-fig4){#respfig4}

In fact, Brisk and NonBrisk groups are very well balanced in the "Active" and "Exhausted" groups.

![](elife-53008-resp-fig5){#respfig5}

If we combine both parameters (Brisk and Active), we can redefine as the bad prognosis group NonBrisk patients with exhaustion and the good prognosis patients all the other 3 groups (Brisk patients with activation, Brisk patient with Exhaustion, and NonBrisk patients with activation). The resulting KM in this case is the following:

![](elife-53008-resp-fig6){#respfig6}

These graphs and this explanation have been considered by the authors asthe Gene Expression Omnibus (GEO) dataset (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE72056). This dataset included 4645 cells from 19 tumors, each annotated with 23684 gene IDs (HGNC format). 1389 tumoral cells were removed leading to a dataset composed by 3256 cells with the following annotation: Bcells (512), CAF (56), Endothelial (62), Macrophages (119), NK (51), Tcells (2040), and unknown (416).

For every cell, we first calculated a distance value (Spearman correlation) to each gene signature from the ones included in the LM22 dataset from Cibersort. For each cell, the highest correlation was selected as the predicted cell type. Cells with a maximum correlation coefficient smaller than 0.25 (764) were removed from further analysis, leaving a total of 2492. Supplementary file 1 shows the contingency matrix between the cell label given by Tirosh and the


not shown in Figure 4C.

Legend has been added in Figure 4, the font has been enlarged, all cell types are now kept constant in all the 4 schemes (before only the ones involved in relevant interactions were shown.

> c\) Please discuss how the fact that the \"active\" and \"brisk\" plots are nearly identical fits with the paper\'s main conclusion that the \"brisk\" state consists of both active and exhausted.

It is true that the neighbourhood analysis profile of the brisk cases was very similar to that of active cases and that non-brisk cases showed more cell-cell interactions linked with immune suppression. Nevertheless, both categories were not totally overlapping with the active and exhausted plots, but rather presented also some of the immune-stimulating and immune-suppressive interactions present either in theto the results. Please clarify how the fact that 50% of the brisk and 43% of the non-brisk tumours can be classified as \"active\" fits with the neighbourhood analysis, particularly point 2C above.

Since our TMA is composed exclusively of primary melanomas, one may object that in a metastatic setting cases with mainly active TILs may not be detected, maybe because the immune system of the patient is failing in keeping control of the tumor. Or maybe, in the metastatic setting to see a diffuse TILs infiltrate in a metastatic nodule would have been possibly correlated with real activation and not with exhaustion, and only morphological evaluation could be enough to evaluate the activation status of the TILs. To avoid to discover at a later research stage that in


the maximum value of PC1. As seen in 3D plot and supported by the projections on Figure 2C, points near the vertex (centroid of the projection in Figure 2C), do not show a strong expression for any marker. On the other hand, points close to the base of the pyramid (low values of PC1) show a strong differential expression of the activation and exhaustion markers. Therefore, PC1 was disregarded for the activation/exhaustion analysis and only PC2 and PC3 were used. Figure 2---figure supplement 3 and legend have been updated.

![](elife-53008-resp-fig12){#respfig12}

> 6\) Correlation between core status and tumour regression. Please answer the following questions:a) How is a late regression area defined?

According to Botella-Estrada et al., 2014 "The presence of regression was evaluated according to criteria previously established by a detailedinfiltrate contains a more complex network of interactions with many of them contributing to immune impairment and, therefore, to the detected lower levels of activation. From Figure 3D it is possible to see that the interactions between active Th and active Tcy disappeared in this group, to leave space to aggregates of B cells located in strict proximity with anergic, proliferating and active T cells and probably stimulated by TIM3+cDC2, counterbalancing the effect of the immune stimulation between cDC1 and active Th. These data support the relationship between activation and late, but not early, regression. This discussion has been added to subsection "Neighborhood analysis" and to the Discussion section. Figure 3 has been added.

> 7\) The reviewers agreed that it is necessary to add a section in the


good folks, we're going to hunt them down, and we're going to find them, and we will bring them to justice." -U.S. President George W. Bush

"Americans should not expect one battle, but a lengthy campaign, unlike any other we have ever seen. It may include dramatic strikes, visible on TV, and covert operations, secret even in success." -U.S. President George W. Bush

"And this is an administration -- we're not into nation-building, we're focused on justice. And we're going to get justice. It's going to take a while, probably. But I'm a patient man. Nothing will diminish my will and my determination -- nothing." -U.S. President George W. Bush

"And we will win the war, and there will be costs. But the military folks understand that, and so do I,humanity." -Rachel Carson

"The love of one's country is a splendid thing. But why should love stop at the border?" -Pablo Casal

"We are convinced that non-violence is more powerful than violence. We are convinced that non-violence supports you if you have a just and moral cause...If you use violence, you have to sell part of yourself for that violence. Then you are no longer a master of your own struggle." -Cesar Chavez

"In all of his suffering, as in all of his life and ministry, Jesus refused to defend himself with force or with violence. He endured violence and cruelty so that God's love might be fully manifest and the world might be reconciled to the One from whom it had become estranged. Even at his death, Jesus cried for


outdated no matter how many cling to it in the stubborn belief that it still works and that it's still valid." -Gerard Vanderhaar

"The story of the human race is characterized by efforts to get along much more than by violent disputes, although it's the latter that make the history books. Violence is actually exceptional. The human race has survived because of cooperation, not aggression." -Gerard Vanderhaar

"The soul of our country needs to be awakened . . .When leaders act contrary to conscience, we must act contrary to leaders." -Veterans Fast for Life

"Always forgive your enemies. Nothing annoys them more." -Oscar Wilde

"In 1989, thirteen nations comprising 1,695,000 people experienced nonviolent revolutions that succeeded beyond anyone's wildest expectations . . . If we add all the countries touched by majorStuffed Dates Recipes

Mascarpone stuffed dates couldn't be a simpler appetizer to assemble. I used Deglet Noor dates, which are firm and not overly-sweet. FIrst, I pitted them and stuffed them with a coffee and rosemary-flavored mascarpone cream. This could surprise, but coffee pairs incredibly well with meat and with the addition of earthy rosemary, the duck prosciutto didn't feel lonely. These appetizers made a greatsnack; baby Aria and I enjoyed them a lot!

Please save the date for my upcoming book signing appearances. The next ones are taking place at Barnes and Noble. If you're in the Bay Area, be sure to stop by Barnes and Noble Blossom Hill, 5353 Almaden Expressway, Building B in San Jose, California. I'll be doing a cooking demo, followed by a book signing,


add to current offerings as follows: one lunch symposium featuring three invited speakers on a topic of current interest (to be identified each year depending on developments in the field), a student travel fellowship program, improvement of audio-visual support to accommodate technology developments in the field, and structural support for the graduate students and faculty advisor involved in the organization of the conference.DCP. That interactive format went on to sell in over 25 territories and will debut in the U.S. on June 22.

With buyers all on the hunt for primetime formats that rise above the crowd — and which ideally have been tested elsewhere — Boom! could follow in Rising Star‘s footsteps. That singing competition debuted to record ratings in Israel shortly before last October’s Mipcom market, allowing KI to go to Cannes boasting a big local hit. Its out-of-the-box selling point was its interactive aspect. Boom!, meanwhile, “fuses the drama, intensity and thrill of a blockbuster action movie with the high octane fun of a video game.” Its debut on Israel’s Channel 2 in the 9 PM slot last night scored a 41.2% share and a 26.7% household rating,


I’m not liking is continuing from last year. The Rockies ended their BP early thus depriving their fans of the only half-hour they get to watch their team take swings.C’mon Rockies, we wait in line in the hot sun so we can come inside and watch you take swings.

We’re allowed a measly half-hour to do this and you end practice 10-15 minutes early?

Listen, I’m not telling the Rockies what to do, I’m just giving them some insight into how fans think.

Graphmaster Gary X hold’n down the front row as per usual.

Mike the Rox Addict and Amy from “The Take from Blake”.

As an old buddy of mine used to say…That’s a crap-ton of balloons.

Matt Belisle giving us a wave.

The ceremonial first pitch times three.

Tulo was presented his Silver Sluggerand Gold Glove award from 2011.

Here are the game pictures I took.

First pitch of the game.

Sandoval homers and the Giants are up by 2 in the first inning.

Helton third out toss-up.

Tulo milliseconds before his first hit.

Chacin starting to crumble.

Amy and Jersey Geoff chill’n.

My favorite picture of the day and one of the hardest to get. Cargo breaking his bat with the ball in the picture.

Zito was straight up money today and the Giants embarrass the Rockies on their Home Opener 7-0.

After the beating was over Mike, Gary X, Alannah and I headed over to where the post-game show is broadcast. We said we would do the “Bring Back Helmer” chant and we did.

Here’s the first video. You can see us in the background.

In this video you can hear


me state for the record, I like all of the rest of the broadcasters in the Poot Warts line-up although I haven’t watched Joel much as I’m boycotting the Post-Game going forward.

The protest had absolutely nothing to do with any of you, it was a protest against your employer. We were standing up and making a statement for a friend who was wronged by a company that claims to be about “The Fan”, but in reality doesn’t give a shit about “The Fan”, simple as that.

I’m “D” The Ranter and let me reiterate, meeting Dante Bichette was the highlight of this day, but it’s nice to know Rockies fans are taking Purple Mondays seriously 🙂Q:

avoiding problems with spring cglib proxy

Using cglib proxies in spring causes:
a) double invocation of constructor
b) not allow to intercept a method invoked from another method
but why spring creates a bean and then a proxy? is it possible to dynamically generate class that extends a specified bean class and then invoke constructor only once? that would solve a) and b) for public and protected methods. am i missing something?

A:

Good question. I think it's due to how Spring bootstraps application context: it first creates all raw beans and then applies post processors, e.g. adding AOP (including transactions). This layered architecture requires creating normal bean first and then wrapping it. One might argue that this approach follows composition over inheritance principle.
Also note that a) should not be a problem. Class should


teammate Antonio Coleman's shoulder pads, and he didn't get up.

It happened so fast that, "I thought the guy on the bottom was injured," Coleman said.

Etheridge knew something was wrong immediately.

"I was in shock just not being able to move," he said. "The only thing I could say was, 'Jesus, Jesus' . . . just calling out his name."

Etheridge was hurt, and lucky. He had landed on Scott, but Scott didn't move, and thus didn't jostle Etheridge.

"If I had moved, he could have been paralyzed," Scott said.

Ole Miss coach Houston Nutt said Etheridge was lucky because "we are always coaching to get off the ground and get back to the huddle. It was really a miracle he didn't push the guy out of the way like we normally do."

Bynes,unmodified form with an asterisk. *n* = 3

Various environmental stresses can increase/decrease sumoylation, and stress stimuli have been shown to boost the interaction between SUMO and several of its target proteins to provide an important post-translational regulatory mechanism \[[@CR31]\].

To examine whether stress has an effect on NICD1 sumoylation, we transfected HeLa cells with GFP-Flag-NICD1 together with either His-SUMO1 or His-SUMO3 and heat-shocked the cells. Heat shock significantly enhanced modification of NICD1 by both His-SUMO1 and His-SUMO3 (Fig. [2c](#Fig2){ref-type="fig"}). Heat-shocked cells with transfected SUMO displayed several bands between 150 and 250 kDa, indicating that NICD1 potentially contains multiple sumoylation sites (Fig. [2c](#Fig2){ref-type="fig"}). Ligand-activated Full-Length Notch1 (FLN; Supplementary Fig. [1A](#MOESM1){ref-type="media"}) and endogenous Notch (Supplementary Fig. [1B](#MOESM1){ref-type="media"}) were also shown to be sumoylated as NICD1. Without overexpressed SUMO, sumoylation of NICD1 decreased significantly, supporting the notion that conjugation


in the form of Bortezomib (Brz). The relative expression of mRNA was analyzed by quantitative RT-PCR *n* = 3

To examine whether mutated NICD1 (*NOTCH1-TSM)* lacking the domains necessary for proper sumoylation retains a capacity to activate downstream target genes in vivo, we electroporated chick embryos with vectors either encoding wild-type NICD1 *(NOTCH1-WT)* or the mutant *NOTCH1-TSM*. When electroporated, both constructs inhibited the upregulation of the neuronal marker TUJ1 and induced expression of the Notch1 target gene *Hes5* (Figs. [6a--d](#Fig6){ref-type="fig"}). However, when heat-shocked at 55 °C for 1 h prior to retrieval there was a pronounced reduction in RNA levels of *Hes5* in the embryos electroporated with *NOTCH1-WT* (Figs. [6e, f](#Fig6){ref-type="fig"}). In contrast, in embryos electroporated with *NOTCH1-TSM* there was still a robust increase in *Hes5* expression despite the heat shock (Fig. [6g, h](#Fig6){ref-type="fig"}). The effectsthan tranquilizers. In fact, games offer dramatic benefits for all children, but especially for children who are ill and have restricted opportunities for benefits from other sources. Child's Play, Ben's Game, game designers, and gamers across the world are showing that video games help people.

The Penny Arcade webcomic artists Gabe and Tycho started Child's Play. Child's Play sponsors children's hospitals so that gamers, geeks, and other involved citizens can directly purchase games for children in hospitals. Certainly a noble cause in its own right, what's even more impressive is that Child's Play has raised nearly a million dollars over the past three years and it collects no administrative fees-all of the money and games go directly to children in hospitals. Child's Play is expanding this year to include


requested an online game to help other children who were battling cancer like him. LucasArts software engineer Eric Johnston worked with Ben to develop a game and the game, entitled "Ben's Game" was subsequently released online. "Ben's Game" has now been downloaded by over a hundred-thousand people and translated into nine languages. The Dalai Lama even honored Ben and Eric on November 6 as two "Unsung Hero of Compassion."

Where Child's Play and Ben's Game focus on sick children in particular, video games offer benefits for all players in general. As gamers we already know this, but we need to spread the word so that nongamers also know about the benefits that games offer. Getting involved with Child's Play or sharing the benefits of gaming with a friend orheavy goods vehicles. This results in an increase of the size and weight of the gearbox.
There are also requirements for high reliability and high dependability of the components comprised in the drive device. In case the gearbox comprises multi-plate clutches, a wear arises, which impacts the reliability and life of the gearbox.
At regenerative braking, kinetic energy is converted into electric power, which is stored in an energy storage device, such as accumulators. One factor impacting on the life of the energy storage device is the number of cycles in which the energy storage device provides and extracts power to and from the electric machines. The more cycles, the shorter the life of the energy storage device.
Under some operating conditions, it is desirable to shut off the combustion engine,


President Trump orders U.S. companies to look for alternative to China, Apple and chip stocks slide

Apple CEO Tim Cook laughs with U.S. President Donald Trump as the news media leave the room after the two men spoke while participating in an American Workforce Policy Advisory Board meeting in the White House State Dining Room in Washington, U.S., March 6, 2019. (photo: Reuters/Leah Millis)

Shares of Apple and semiconductor stocks slid on Friday after President Donald Trump said U.S. companies should “immediately start looking for an alternative” to their operations in China.

The tech-heavy Nasdaq was off 2.6%, while the Dow Jones Industrial Average slid 2.3% and the S&P 500 fell 2.5%.

Trump’s comments on Friday mark the latest fallout in the trade war between the U.S. and China.

….better off without them.flat regions, which can characterize geometric features of a protein structure. The visibility used in VisGrid is defined as the fraction of visible directions from a target position on a protein surface. A pocket or a hollow is recognized as a cluster of positions with a small visibility. A large protrusion in a protein structure is recognized as a pocket in the negative image of the structure. VisGrid correctly identified 95.0% of ligand-binding sites as one of the three largest pockets in 5616 benchmark proteins. To examine how natural flexibility of proteins affects pocket identification, VisGrid was tested on distorted structures by molecular dynamics simulation. Sensitivity decreased approximately 20% for structures of a root mean square deviation of 2.0 A to the original crystal structure, but specificity was


a DEA expert.  The results of both tests indicated that appellants were truthful in denying the assaults.  The agents refused to submit to polygraph examination.  The DEA concluded that further investigation was not necessary and that a case of perjury had not been made.  The trial judge was advised of the foregoing, and appellants' motion for new trial was granted.  On retrial before a different judge, Hitchmon and Fussell again were convicted of the assault offense.  This appeal followed.

4
Fussell was an employee of Pan Am at the Miami International Airport; Hitchmon was an acquaintance of Fussell.  The DEA learned that a large shipment of marijuana had arrived at the airport and was being stored in Pan Am's cargo warehouse.  Anarcotics surveillance was ordered in an attempt to apprehend and arrest the owners, who were unknown to the DEA.  During the early morning hours of April 25, 1975, DEA special agents Herbert Williams and John Andrejko were watching the warehouse from their car parked nearby.  To avoid detection, they were lying on the car seats.  According to the agents' testimony, three black males, appellants and a Vincent Hall,1 drove up in a green Volkswagen and parked approximately ten feet away.  Hitchmon and Hall, they said, got out of the Volkswagen and approached the agents' car, while Fussell remained behind.  Hall, their testimony continued, tapped on their car window with a shotgun and ordered them to get out at gunpoint; Hitchmon, meanwhile, stood in


was a pure fabrication.

7
Appellants contend that the DEA agents made up their story because they had blown their surveillance of the warehouse by pursuing and arresting the wrong suspects.  They suggest that the agents' scenario was concocted after the prosecutor discovered that the evidence was insufficient to charge the appellants with conspiracy to import marijuana.

8
There is support in the record for appellants' claim.  The charges against them were listed on both the United States Marshal and Dade County booking forms as conspiracy to import marijuana, but later they were changed to assaulting federal officers.  Additional credence is given appellants' account by a peculiar discrepancy developed in the trial testimony of another Government witness, Customs Officer Edward Ostrowsky.  Customs joined the DEA in conducting thethe DEA investigation.  This, too, was an inappropriate restriction on the right of cross-examination, because the agents made statements during the investigation that, in view of what they said at trial, were matters to be considered by the jury in assessing their credibility.  That the agents were subject to disciplinary action if they agreed with appellants' depiction of the facts is also something that the jury may have wanted to know in deliberating about the credibility issues.  Since the cross-examination was short-circuited, however, the extent of permissible inquiry into the investigation is a matter that will have to await the new trial.  The issue in the DEA investigation was the same issue that needs to be decided in this case: whether the Government witnesses


1953 (Pt. 2, Supp. 1969) provides, in part:
"Receipts from transactions in interstate commerce may be deducted from gross receipts to the extent that the imposition of the gross receipts tax would be unlawful under the United States Constitution."
*322 The Supreme Court in Albuquerque Broadcasting Company v. Bureau of Revenue, 51 N.M. 332, 184 P.2d 416 (1947) held, with respect to programs and national spot advertising supplied by out of state broadcasting companies and advertisers, as follows:
"These programs are thus broadcast over sixteen states and parts of Canada and Mexico. They are communications directed to all persons listening to the broadcasts wherever they may be. This business is strictly interstate and we can discover no incident in connection therewith that could be classed as a `taxable event.' The ideathat there are means by which the state can lay a tax on these activities so that appellant will be required to pay `its just share of state taxation' in return for the protection it receives, is either a delusion, or else we are unable to discover the means through which it may be required to respond, in view of Freeman v. Hewit, [329 U.S. 249, 67 S.Ct. 274, 91 L.Ed. 265 (1946)]. We are of the opinion that the tax so laid and collected on the gross receipts from these broadcasts must be returned to appellant." 51 N.M. at 354, 184 P.2d at 430.
Taxpayer concedes that it is not entitled to question, and it does not question, the propriety of the exemption or immunity enjoyed by radio


pouring a piece that is 1/4 inch deep you will want to mix your resin using 1 oz of resin and 9 drops of catalyst. If you need more resin than 1 oz you would double the recipe: 2 oz of resin and 18 drops of catalyst and so on.

If you're pouring a piece that is 1/2 inch deep you will mix 1 oz of resin and 5 drops of catalyst.
The deeper the resin is the more heat will build up and you'll need less catalyst.

If you are making something very deep you will want to work in layers.
The first layer might be 1/4 inch deep using 1 oz of resin and 5 drops of catalyst. But when you mix the resin for the second layer, even thoughmaterials have been developed for the cutting structure of the cones thereby providing a longer useful lifetime for the cones. This has resulted in the bearing system being first to fail during the drilling operation. Consequently, a need exists for an improved bearing system to extend the useful lifetime of the bit.
In order to obtain high penetration rates with a rotary rock bit in some formations, it is necessary to apply heavy loads on the bit and to operate the bit at a moderate speed. With other formations only moderate loads are required but the bit must be operated at relatively high speeds. The rock bit operates under a highly corrosive environment and is subjected to temperature extremes. The drilling operation may be conducted thousands of feet underground


of E3S and 10 µg/mL biphalin in the 37 °C incubator for 20 min. The incubation time, 20 min. was selected to get detectable amount of biphalin in the cell extract. Next, the cells are washed two times with ice-cold phosphate buffered saline (PBS, pH 7.4). The cells were solubilized with 100 µL radioimmunoprecipitation assay (RIPA) Buffer (Thermo Fisher, Waltham, MA, USA) with protease and phosphatase inhibitor cocktail (Thermo Fisher, Waltham, MA, USA), and the amount of biphalin uptake was determined by using the above LCMS method. Protein content was calculated with a detergent-compatible bicinchoninic acid (BCA) assay (Pierce Chemical, Rockford, IL, USA). Biphalin uptake was normalized while using protein content and then presented as biphalin (ng) per µg of protein.

2.5. Biphalin Transcellular Transport Studies {#sec2dot5-pharmaceutics-11-00467}
---------------------------------------------

Transport studies werestroke outcomes better than selective agonists \[[@B7-pharmaceutics-11-00467]\]. Biphalin is an example of non-selective, ultra-potent, peptide based OR agonist that has higher affinity to MOR and DOR and less affinity to KOR \[[@B42-pharmaceutics-11-00467],[@B43-pharmaceutics-11-00467]\]. The original rationale for the synthesis of biphalin was the higher probability of interaction of the molecules with two active sites of the receptor, and also of unique interaction with proteolytic systems \[[@B44-pharmaceutics-11-00467]\]. Biphalin has been well studied for its analgesic activity during inflammatory pain and has shown better activity than morphine when intracerebrally administered \[[@B45-pharmaceutics-11-00467]\]. These unique properties of biphalin, high receptor affinity to MOR, DOR, and KOR and potent antinociceptive activity, are the results of the rigidity of the hydrazide bond between two active chains \[[@B46-pharmaceutics-11-00467]\]. It has been proposed for the treatment of


abdominal pain that is associated with inflammatory bowel disease \[[@B47-pharmaceutics-11-00467]\] and has also been proposed to be better than morphine in the management of cancer associated pain \[[@B43-pharmaceutics-11-00467]\]. With this pharmacological profile, biphalin remains one of the best preclinical peptides based opioid analgesics \[[@B42-pharmaceutics-11-00467],[@B48-pharmaceutics-11-00467]\]. Most importantly, biphalin exerts less dependence and tolerance than the classical opioid receptor antagonist morphine \[[@B42-pharmaceutics-11-00467],[@B49-pharmaceutics-11-00467],[@B50-pharmaceutics-11-00467]\]. This could be attributed to its affinity to KOR, which results in combating the MOR and/or DOR agonist-mediated adverse effects, like psychological and physical dependency, and tolerance \[[@B51-pharmaceutics-11-00467]\].

It was reported that biphalin works better than other selective opioid agonists in decreasing edema formation and infarct size ratio in mice middle cerebral artery occlusion (MCAO) model when administered 10 min. after reperfusion \[[@B6-pharmaceutics-11-00467]\]. In addition, biphalin demonstrated equivalent efficacydevelops around puberty, ensures normal levels of thyroid hormone \[[@B2]\].

Pendrin is a Na^+^-independent exchanger for anions such as Cl^-^, I^-^, HCO~3~^-^and formate \[[@B8]-[@B10]\]. Pendrin is expressed in the inner ear, thyroid, kidney, mammary gland, uterus, testes, and placenta \[[@B6],[@B11]-[@B17]\]. In the thyroid, pendrin is expressed on the apical side of the thyrocytes and mediates Cl^-^/I^-^exchange. In the kidney, pendrin is expressed on the apical side of the non-A, non-B intercalated cells, cytoplasmic regions of the type B intercalated cells of cortical collecting tubules, distal convoluted tubules and connecting tubules and mediates Cl^-^/HCO~3~^-^exchange \[[@B14],[@B18]\]. Loss of pendrin does not effect the arterial pH but results in a lower urinary pH \[[@B19]\]. In the inner ear, pendrin is localized in the outer sulcus epithelial cells, root cells, apical membranes of


either used immediately or diluted and stored at -80°C for later analysis (RNA storage solution, Ambion, Austin, TX, USA).

Gene array
----------

Total RNA was isolated from stria vascularis of adult *Slc26a4*^+/+^and *Slc26a4*^-/-^mice (P148 ± 3 and P153 ± 1, respectively). The minimal amount of blood present within capillaries was deemed insignificant; no cardiac perfusion was performed. Isolated RNA was concentrated and frozen for shipment to the Biotechnology Support Facility at University of Kansas Medical Center. A total of six chips were run; each chip was used to analyze RNA pooled from two animals. Three chips each were used to analyze RNA expression in stria vascularis of *Slc26a4*^+/+^and *Slc26a4*^-/-^mice. RNA was amplified by two rounds of amplification, and cRNA was hybridized to high-density oligonucleotide gene chips (Small sample protocol, version II;stria vascularis and spiral ligaments, as well as from liver and spleen. In each 96-well plate, the expression of seven different genes as well as 18S rRNA was analyzed. Total RNA from stria vascularis and spiral ligaments or from spleen and liver of one *Slc26a4*^-/-^and one matched *Slc26a4*^+/-^mouse was analyzed in duplicate reactions in parallel to allow paired comparisons (paired t-test). qRT-PCR was performed in the presence of 0.5× SYBR green I on total RNA isolated from individual animals using gene specific primers (One step RT-PCR kit, Qiagen; iCycler, BioRad, Hercules, CA, USA; SYBR green I, Molecular Probes; Table [2](#T2){ref-type="table"}). RT was performed for 30 min at 50°C and 15 min at 95°C. PCR consisted of 40 cycles of 1 min at 60°C, 1 min at 72°C, 20


observed in *Slc26a4*^+/-^mice. The scale bar shown in the bottom right image represents 10 μm and pertains to all images in this figure.](1741-7015-4-37-1){#F1}

Marginal cells can be identified by there expression of the K^+^channel *Kcnq1*in their apical membrane \[[@B17]\]. To gain information on the identity of surface epithelial cells, expression of *Kcnq1*was visualized by immunocytochemistry and F-actin, a marker for tight junctions, was visualized by phalloidin staining. Marginal cells at all ages of *Slc26a4*^+/-^mice and at P10 and P15 of *Slc26a4*^-/-^mice expressed the K^+^channel *Kcnq1*evenly. Little variation was observed in cell surface areas at all ages of *Slc26a4*^+/-^mice and at P10 and P15 of *Slc26a4*^-/-^mice, and variations appeared normally distributed (Figs [2](#F2){ref-type="fig"} and [3](#F3){ref-type="fig"}). The average cell surface area of marginal cells in *Slc26a4*^+/-^mice was 104 ± 2 μm^2^(ninducible   19               0/3              27    0/3

Genes that can serve as markers for acute inflammation (1--9) are listed. For parameters \'P\', \'Fold\' and \'Direction\', see the Gene array section in Methods. Fold changes are given when a gene was called Present (P) in *Slc26a4*^+/-^or *Slc26a4*^-/-^stria vascularis in at least half of the available probes. The direction of the fold change is only given when it exceeded 1.30. Fold changes lower than 1.30 were not considered significant.

Macrophage invasion is restricted to stria vascularis
-----------------------------------------------------

The observation that stria vascularis of adult mice is invaded by


model (BNLM + RNN-BNLM 100M) we are able to significantly outperform both of them (2.7% rel. WERR).

Switching to subword setups we observed the following results: the simple act of replacing words with subwords in the baseline BNLM already yields a significant WER reduction (3.4% rel.). The LM trained on the 100-million-morph generated corpus (RNN-BNLM 100M) has the same WER as the morph-based BNLM (21.1% WER). However using a ten times larger corpus to train the approximative model reverses this trend: morph-based RNN-BNLM 1B model is the first augmentation model that outperforms a baseline BNLM by itself, without taking any benefit from interpolation (20.5% WER). When adding interpolation, we can leverage a further increase in performance. BNLM + RNN-BNLM 1B model can reduce WER of morph-based BNLM by 5%had recently received a 7-day course of acyclovir for shingles and amoxicillin for a presumed urinary tract infection. Her home medications included Indapamide, Felodipine, Levothyroxine, and Rosuvastatin. On arrival, physical examination and vital signs were unremarkable except for a blood pressure of 184/47 mm of Hg. Initial laboratory work revealed serum potassium of 3.1 mmol/liter (mmol/L). EKG at presentation showed sinus rhythm with left bundle branch block (LBBB), frequent PVCs and moderately prolonged corrected QT interval. She was given potassium supplementation and was planned to be discharged home from the emergency room, however, she had two episodes of syncope from PVC-triggered polymorphic ventricular tachycardia PMVT/VF, both terminated by defibrillation. Amiodarone infusion was started and she was transferred to our hospital for electrophysiology evaluation.

EKG upon arrival to our hospital ([Fig. 1](#fig1){ref-type="fig"}A) showed


Q:

AWS Missing Authentication Token

I am following this tutorial for connecting Raspberry Pi to AWS IoT using Node.js SDK. I see the following in vim ~/.aws/credentials
[default]
aws_access_key_id = SOMETHING
aws_secret_access_key = SOMETHINGELSE

When I enter the command aws iot describe-endpoint I get the following response:
{
    "endpointAddress": "A34SXNTM6AT7XH.iot.us-west-2.amazonaws.com"
}

However when I browse to that URL: https://a34sxntm6at7xh.iot.us-west-2.amazonaws.com/
I get the following error:
Missing Authentication Token

Any idea what could be wrong and how could it be solved?

Here's the files in the ~/certs folder:
pi@raspberrypi:~/certs $ ls
certificate.pem.crt  private.pem.key  public.pem.key  root-CA.pem

A:

Mona,
Your custom endpoint responds to two protocols: MQTT and HTTPS. However, it does not serve any web content and thus does not work in the browser as a site URL. The "endpointAddress" you get from aws iot describe-endpoint will be plugged into your Node.js Devicebirding, while the rest camps and picnic sites are exceptionally rewarding for birders.

Berg-en-Dal

The camp is an excellent venue to see Grey Tit-flycatcher (Fan-tailed Flycatcher), White-browed (Heuglin's) and White-throated Robin-chats. Scarlet-chested Sunbird is particularly prominent. The adjacent Matjulu Dam attracts a constant supply of water birds and African Fish Eagle is usually present and viewed at close quarters. The surrounding hills host a wealth of species and are a good place to search for Pennant-winged Nightjar (in summer and at dusk) and Croaking Cisticola. Orange-winged (Golden-backed) Pytilia were recorded by several people in the camp during the 2004 winter.

Bushveld Camps

The parks' 5 bushveld camps all offer superb birding opportunity. Camps in general attract a boon of birds. They are all well foliaged and usually next to water-courses. The advantage


looked for in the camp and like most camps in the central and northern parts of the park Mourning Dove is particularly prominent. The camp's Red-headed Weavers are unusually bold (they nest adjacent the petrol station and in front of the restaurant. The riverbed usually hosts a wide range of herons, storks and waders. Look carefully for Greater Painted Snipe.

The Matambeni Bird Hide on the northern bank of Engelhard Dam is a good place to watch water birds. On the south bank of the dam, near the dam wall Collared (Redwinged) Pratincoles appear annually and can sometimes be seen from the rest camp.

The Masorini Ruins close to the Phalaborwa Gate is a good venue to view Yellow-throated Petronia (Sparrow), Mocking Cliff-Chat and Red-headed Weaver. The nearby Sable Damwet season of 1999-2000 plenty of Black Coucal. In 2001 a Narina Trogon (not previously recorded in the area) flew into the window of one of Talamati's cottages and killed itself.

Pafuri Region

The drives along the banks of the Levuvhu River via the Nyalaland Drive (S64) or the picnic site/Crook's Corner loop (S63), take visitors through some of the most potentially productive birding territory in South Africa. One can simply spend several hours in the Pafuri Picnic Site itself, with Trumpeter Hornbill, Purple-crested Turaco (Lourie), Black-throated Wattle-eye (Wattle-eyed Flycatcher), Tropical Boubou, Meve's (Long-tailed Starling), Narina Trogon, Thick-billed Cuckoo (summer only), Gorgeous, Grey-headed and Orange-breasted Bush-shrike and several different species of robin, sunbird and firefinch all potentially swelling one's list. Other rarities for the Park recorded at the picnic site


0 of 30

Ezra Shaw/Getty Images

You take the good, you take the bad, bake in an NBA spin, and what do you have?

The best and worst contract from every team.

Inventorying each squad's crowning jewel and bookkeeping blemish is always pertinent in the aftermath of free agency. But this compilation is especially important now, with the Association still trying to restore balance following a dizzying number of overpays in 2016.

Best-contract picks are reserved for players who provide the most bang for their buck. Their deals are team-friendly in both length and price, and they're exceeding expectations incumbent of their pay grade.

Worst-contract selections vary by the team. Some of them are truly bad. They belong to blatantly overpaid players, many of whom cannot be traded without steep incentives or, sometimes, atLindsey Graham arguing against nominating a Supreme Court justice in an election year goes viral Sunday shows preview: Justice Ginsburg dies, sparking partisan battle over vacancy before election Democrat on Graham video urging people to 'use my words against me': 'Done' MORE (R-Texas), who have all voted for the anti-trafficking legislation.

Outside groups are also coming off the sidelines.

The National Republican Senatorial Committee is making robocalls against five Democratic senators who are up for reelection in 2016: Reid, a top GOP target, as well as Sens. Michael Bennet Michael Farrand BennetOVERNIGHT ENERGY: House Democrats tee up vote on climate-focused energy bill next week | EPA reappoints controversial leader to air quality advisory committee | Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' Senate Democrats demand White


to this increased awareness of the general problems with research. I had never made that connection before.

My sense is that there is some truth to this, but it is not the whole story. I do agree with Engber’s central claim, made in his headline: “Daryl Bem Proved ESP Is Real, Which means science is broken.” That is a more dramatic way of saying what I stated above – it is more likely that Bem’s science is broken than it is that the laws of the universe are radically different than what we think.

It is probably an oversimplification, however, to credit Bem’s publication with the work of Ioannidis, for example, who studies the published literature for patterns of bias. My perspective is a little different since my colleagues anda “Trumpian” admission. He is actually admitting that his research was a “rhetorical device” intended to persuade and not to explore. He was trying to show “that” psi is real, not find out “if” it is real. That, I would argue, is the core failure of the pseudoscientist.

He doesn’t have the patience for rigor – OK, fair enough if you are going to admit it. But the real problem is, when other people do the rigor, as in the replication experiments above, he doesn’t accept the results.

Psi is Dead, Science is Recovering

In a rational world, this entire affair would spell the death of psi research. The hypothesis was never plausible. The strong suspicion that razor-thin positive outcomes were the result of some sloppy research has been largely confirmed.

The


fact remains that no psi research protocol has withstood the test of time, and held up to rigorous replication. There is no psi effect that meets my criteria for being compelling: simultaneously showing a statistically significant effect that also shows a significant signal to noise ratio with highly rigorous experimental protocols that hold up to replication. You can get some of these features with psi, but never all of them.

The most parsimonious explanation for this fact is that psi is not real. A century of psi research is enough. This is a dead end. Psi is pushing up the daisies. It is an ex-hypothesis.

But, as the reaction of Bem and his colleagues demonstrate, the world is not rational.

Meanwhile, back at mainstream science, the Bem affair was a bit0.1
Let y(p) = 2*p**3 - 30*p**2 + 4. Let m be y(15). Which is the closest to -11?  (a) -0.1  (b) -0.4  (c) m
b
Let h = 58 - 58.14. What is the closest to -1 in h, -1/6, 0.2?
-1/6
Let y = -0.08 + 0.38. Which is the closest to -2/39?  (a) 3  (b) y  (c) -2
b
Let j = 2.03 + -2. Let y = j - -1.97. Let f = 8 - 11. Which is the nearest to 1?  (a) 0.1  (b) y  (c) f
a
Let u be ((-4)/42)/((-2)/6). Which is the closest to u?  (a) -3  (b) -4  (c) 0.2
c
Let p be (1 + (-11)/12)/((-12)/(-32)). What is the closest to -1/2 in -4, p, -1?
-1
Let g


be (-4 - -2)/(-1 + -3). Let w = 2 - -2. Which is the nearest to -1?  (a) w  (b) g  (c) -1/4
c
Suppose 4*t - t = 0. Suppose 5*m - 9*m = 0. Let k = -2 + -2. Which is the nearest to t?  (a) k  (b) m  (c) -1/4
b
Let m = 11/42 + -1/84. Which is the nearest to -0.1?  (a) -2/9  (b) m  (c) 0.4
a
Let f = 3 + -7. Which is the closest to -1?  (a) f  (b) -2  (c) -1
c
Let n be -1 - -1 - 4/34. Suppose 1 + 14 = -5*c. What is the closest to 1 in n, c, -0.2?
n
Let d = -1.4 - 0.6. Letrequire a development environment.  It just needs to be able to launch the program to be profiled (so it has to run on the same machine) and the program has to have a .MAP file generated by the linker in the same folder as the .EXE.  If this is in-house, that shouldn't be a problem for you.
And if you look at the helpfile, you'll even find ways to have it only profile certain sections of your program, which AQTime can't do.  That helps if you know the issue is in one specific place, such as the startup code.

A:

Why not install AQTime on the machine and use it as a standalone profiler? No need for an "entire D7 IDE development environment".


first visit to court, and who appeared to be under the impression that the King was hard of hearing. At any rate, he made the most extraordinary efforts to speak loud and to pronounce his words distinctly. The King maintained an impassive countenance, but ended by interrupting him:

Lastly, let me recall his caustic reply to one of our most uncompromising radical deputies, who was being received in audience and who, falling under the spell of King Leopold's obvious intelligence, said to him, point-blank:

"Sir, I am a republican. I do not hold with monarchies and kings. Nevertheless, I recognise your great superiority and I confess that you would make an admirable president of a republic!"

"Really?" replied the King, with his most ingenuous air. "Really? Do you know, I thinknear Fontainebleau, which the King had hired for the season... there was a violent scene with the cook, who had had the temerity to charge for seventy-five eggs in six days. Mme. de Vaughan was justly annoyed, dismissed him on the spot and refused to pay him the usual wages instead of notice...

Great as was the influence which Mme. de Vaughan had gained over the King's mind, I am bound to confess that it was never exercised in political matters nor in any of Leopold's financial undertakings. The baroness knew nothing about those things and made no attempt to understand them. The King was grateful to her for this discretion, which in reality was only indifference, for he never allowed any outsider to interfere in his affairs, whether


work that have made Fanbase Press what it is today, but also a chance to identify *why* Fanbase Press exists, why our staff and creators put in the time and efforts that they do, and why we will continue to serve our community for another 10 years and beyond.

What we realized is that the answer is not exclusive to Fanbase Press. It's not exclusive to comics, to fandom, or even to the United States. Why do we do what we do? Because Stories Matter.

Stories Matter. It's a simple phrase, but one full of depth. Since the birth of humankind, it has been through stories that we are able to examine the essentials of human existence, to understand ourselves better and to grow and/or heal, to pass on importanceknows, some days are better than others).

Yesterday I received the phone call I had been dreading - my friend of so many years had passed away. A short while later the information was released to the media. I have met many wonderful folks who have been long-time Pernell Roberts fans, falling in love with young Adam Cartwright on Bonanza, but I met him after he left the show and, though I first was "introduced" to him as Adam on that show, I became far more impressed with his performances as Padraic Madigan (The Big Valley), Jim Boyer (The Virginian), Joey Celeste (The Girl from U.N.C.L.E.), Hezekiah Horn (The Young Riders), and so many other characters that it would (and does) fill pages. I was blessed to have visited


being should be: his efforts on behalf of those less fortunate and those in minority groups have been tremendous, though not publicized as some celebrities do.

I remember when I got a small guest part as a square dance caller on the short-lived TV show with Madeline Kahn - Oh! Madeline! - I called Pernell and his wife to tell them. Pernell got on the phone and bellowed, "Welcome to the big time!" He and his wife recorded my appearance (Butch & I had not yet entered the techy age of VCRs) so that I could remember that "big time." When I was in high school, I wrote a song for him; the chorus goes: "Thank you for just being you;/ No one else could ever do What you'vesights on Match of the Day. Coventry City followed in 2001 after thirty-four seasons, with Leeds United (14) and Southampton (27) joining them in 2004 and 2005 respectively. Indeed, 2001/2002 was notable for the fact that none of the promoted sides (Fulham, Blackburn and Bolton) felt the need to be excused – Ipswich Town feeling the pinch of UEFA Cup involvement and succumbing to second-season syndrome and Derby County and Leicester departing after 6 years apiece.

It’s not a particularly brave statement to make, but it does benefit from being true – unless you are Manchester United, Chelsea, Liverpool or Arsenal, you’re really not guaranteed a place in the top flight next season until mathematics decrees it. Even our beloved Big Four’s positions are parlous ones, with rafts of


stuff does not work starting with such-and-so API level, the deprecated APIs still work. They may not be the best choice, in light of the alternative, but they still work.
In particular, deprecated APIs sometimes are your only option. The camera is a great example. android.hardware.Camera is the only way to take pictures on Android 4.4 and below. At the present time, that still represents the better part of a billion devices. Here, "deprecated" means "on Android 5.0 and higher, you should consider using android.hardware.camera2". Whether you choose to use both APIs (android.hardware.camera2 on API Level 21+ and android.hardware.Camera before then), or whether you choose to use android.hardware.Camera across the board, is your decision to make.
If you want to offer some sort of guided picture-taking, implementing your own cameraBurger King celebrates LGBT pride with 'Proud Whopper'

The 'Proud Whopper' is a regular version of the sandwich in a rainbow-colored wrapper that reads, "We are all the same inside." (Source: Burger King)

The company announced Wednesday it was selling the Proud Whopper at a San Francisco location through July 3. All sales go to scholarships for LGBT teens. (Source: Burger King)

SAN FRANCISCO (RNN) - Fast-food chain Burger King is making an effort to elevate its "Have It Your Way" slogan with an old favorite in a new packaging.

The company announced Wednesday it would sell the Proud Whopper at a San Francisco location through July 3. It pledged all sales from the burger would be donated to the Burger King McLamore Foundation for scholarships benefiting lesbian, gay, bisexual and transgender