intolerance, rash, hepatotoxicity, acute gout attacks, nephrolithiasis, and nephrotic syndrome.[@b37-ce-4-025],[@b38-ce-4-025]

Unmet needs with older therapies
================================

Few drugs are available for long-term urate-lowering therapy. Uricosurics are of limited application because of the high frequency of comorbidities (particularly renal, which render their use ineffective) and drug interactions, significantly limiting their use in real clinical practice. Only one approved drug, allopurinol, targets the overproduction mechanism of hyperuricemia and its use is limited in some cases by drug interactions, intolerance, and adverse reactions, one of which, the allopurinol hypersensitivity syndrome, is very serious.

There are a number of patients with gout in whom no approved alternative for management of their chronic hyperuricemia is available because of allopurinol or uricosuric intolerances, allergies, or ineffectiveness. A significant proportion of these patients have kidney dysfunction or solid organstudy medication by the investigators. The authors' conclusion was that all urate-lowering endpoints requiring an SUA concentration of 6.0 mg/dL or less were achieved by more febuxostat than allopurinol recipients, but the clinical outcomes (reduction in gout flares and tophi area) were not different.

A second phase III trial of febuxostat has been recently published and expanded upon the results of the FACT study. Named Allopurinol and Placebo-Controlled, Efficacy Study of Febuxostat (APEX), it was a randomized, double-blind, allopurinol and placebo-controlled trial that followed 1072 subjects for 28 weeks.[@b48-ce-4-025] The objective of the study was to compare the safety and efficacy of febuxostat at dosages of 80, 120, and 240 mg/day with allopurinol or placebo. Additionally, an assessment of the effects of treatment with febuxostat in patients with impaired


higher proportion of patients (72%) than in those taking febuxostat 40 mg/day (50%) or allopurinol (42%). Rates of adverse events were comparable across groups and at all levels of renal function. Specifically, no difference was reported in the rate of cardiovascular events (six events were reported: three in the allopurinol arm and three in the febuxostat 80 mg/day group). Five deaths occurred during the study, one in each febuxostat group and three in the allopurinol arm. CONFIRMS also provided additional evidence than that provided by the FACT and APEX trials supporting a stronger urate-lowering potency in the tested doses of febuxostat compared with allopurinol for those individuals with SUA greater than 10 mg/dL or with tophi.

Economic evidence and resource utilization
==========================================

No economic studies of febuxostat have been published in<?php
declare(strict_types=1);

namespace predaddy\domain;

use precore\util\UUID;

/**
 * Provides an easy way to generate unique IDs.
 *
 * It can be extended and only the aggregateClass() method must be implemented.
 *
 * @author Janos Szurovecz <szjani@szjani.hu>
 */
abstract class UUIDAggregateId extends AbstractAggregateId
{
    /**
     * @var string
     */
    private $uuid;

    final private function __construct(string $uuid)
    {
        $this->uuid = $uuid;
    }

    /**
     * @return static
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    final public static function create() : self
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fewer chestnuts if you want to avoid carbs. 10 chestnuts are the general estimate for you to eat daily.

A Recipe for Having Chestnuts

Roasted chestnuts are a popular ingredient in different kinds of dessert. Let’s see how to roast chestnuts:

Ingredients that you need

1 pound chestnuts

1 pinch ground cinnamon

1/4 cup butter

Salt to taste

Now, follow the following steps:

Preheat your microwave oven to 375 degrees F (190 degrees C)

Cut through the shell of each nut to prevent the nut from exploding

On the flat side of each nut, make a 1/2-inch crisscross

Bake them on a shallow baking pan for 25 to 30 minutes

Peel off the shell when they are cool

Put the nuts in a skillet and add butter and salt to it

Heat the skillet to melt the butter to be well coated aroundthem in.

Macadamia nuts are very low in carbohydrate and high in saturated fat. So, these nuts are a great source of healthy fat.

Macadamia nuts can also reduce inflammation and help with muscular strength and endurance after a strenuous exercise

Caution

Macadamias contain a high amount of fat, but they are relatively low in protein. So, eating macadamia can cause you to gain extra weight.

So, if you cannot ignore the taste of macadamia and want to eat them more, you should get on a rowing machine and lose the extra fat you get from them.

How Many Macadamias Should You Eat Daily?

15 macadamias are the general estimate of nuts that you can include in your healthy diet.

A Recipe for Having Macadamias

Chocolate-Macadamia tart is very delicious food to have as a dessert after


one of the most popular and delicious types of nuts in the world. Walnuts are usually used as a snack, but they are also used in various types of food.

Benefits of Walnuts

It also diminishes the risks of cardiovascular diseases and increases the lifespan

Walnuts are also rich in phytochemicals and healthy fats

Caution

Similar to the most of the types of nuts, severe allergies are possible with walnuts. If you are allergic to nuts, consult your doctor before having walnuts.

How Many Walnuts Should You Eat Daily?

9 walnuts are the general estimate of nuts that you can include in your healthy diet.

A Recipe for Having Walnuts

Chocolate walnut fudge is a delicious dessert that uses walnuts in it. Let’s see how to make chocolate walnut fudge.

Ingredients that you need

1/2 cup butter

10 large marshmallows

1benefits are also countless. However, if you are looking for the most nutritious and beneficial nuts for you to eat every day, then almonds, Brazil nuts, and walnuts are the best options for you. They are full of healthy fats, and they contain significant amounts of polyphenols that help your body function without diseases.

From another point of view, if your priority is the taste, then no other types of nuts can match tastes of macadamia. Macadamias are the most delicious nuts in the world. However, macadamias are the most calorie-dense among all the types of nuts. So, don’t eat too much macadamia.


soldering iron and much smaller DIY presses. Have any ideas on how you could use thermal inserts in your 3d prints? Let us know in the comments.

Would you consider this to be doing math the old-fashioned way? Instead of going with silicon-based switching (ie: transistors) this 4-bit adder uses mechanical relays. We like it for its mess of wires (don’t miss the “assembly” page which is arguably the juiciest part of the project). We like it for the neat and tidy finished product. And we like it for the clicky-goodness which surely must bloom from its operation; but alas, we didn’t find a video to stand as testament to this hypothesis.

The larger of the two images seen above is from the register memory stage of the build. The20,000 pounds .... It may come
to be a famous company."(28) A great trade with the natives was anticipated,
and this letter refers to a missive to be dispatched by order of the society by a special messenger, bearing suitable
presents, to the "Emperour of Canada." This document had been already prepared. It was written on parchment,
under the seal of the society and the hand of the president at London, June 19, 1682, and begins thus:

Friend. I have sent you this Letter and Messenger to let you know that I am elected President of the
Free Society of Traders of Pennsylvania and, as I am such, have the Power and Free Consent of all these good men
to treat with you, your Kings, and your people in all things pertaining to Trade.(29)

The society


summer months as during the cold winter.

OBITUARY: George H.W. Bush-era Energy Secretary James Watkins died late last week. The Los Angeles Times: “After taking charge of the Energy Department in 1989, Watkins launched the first program to clean up pollution at the nation's nuclear plants and spearheaded the administration's energy legislation.” http://lat.ms/PWfHTR

— The Wall Street Journal has a closer look at how Chinese state-owned oil companies’ global investments in struggling companies are opening up new production: http://on.wsj.com/N7cltG

— The Senate should quickly follow the House in passing an alternate offshore drilling bill, the American Petroleum Institute and other groups wrote to lawmakers yesterday. The letter: http://politico.pro/QQFtqg

— BSEE says a full-scale exercise deploying the oil industry’s new well containment system was successful. Fuel Fix: http://bit.ly/Qs14uz

— Environmentalists are pointing to this      $this->_totalResultsReturned  = (int) $this->_xpath->evaluate("count(/tapi/document/item)");
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     *
     * @return Zend_Service_Technorati_TagsResult current result
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         * @see Zend_Service_Technorati_TagsResult
         */
        require_once 'Zend/Service/Technorati/TagsResult.php';
        return new Zend_Service_Technorati_TagsResult($this->_results->item($this->_currentIndex));
    }
}


injection needle as insertion aid for a catheter head as described above is described in WO 00/03757. The insertion device has a housing from which an injection needle protrudes in such a way that it reaches through a base body of the catheter head and extends through the flexible cannula of the catheter head. Arranged on one side of the housing of the insertion device, there is a protection device in the form of a sleeve cap which is pivotable relative to the housing and which is open at one end in the direction of the needle. In a first state for insertion of the injection needle, the sleeve cap protrudes from the housing perpendicularly with respect to the needle axis. After insertion of the injection needle, orQ:

Create Lines between points using points ID

I am trying to recreate in QGIS a few diferent sets of constellations. I already have a layer with all the stars I need, with ID and coordinates (downloaded from here astronomyData.zip), and I also have a table with a line for each constellation, and the pairs of stars that need to be connected by ID (link here)
What I need is for some way to have the software look at each pair of IDs, find the coordinate for each star with the same ID the stars layer, and connect each pair with a line.
I feel like this should be easy, but I can't figure out a way.

A:

There doesn't seem to be a simple way to do this with the GUI, because of


brought life to Godzilla and the other daikaiju. The techniques of Harryhausen the mage were therein disclosed, enhancing my pleasure at seeing his creations play out their often fitful lives. The denizens of my reading and viewing might inspire horror in others, but they provided me with both solace and excitement. Such beings who moved outside of the normal realms, whose often extended lives were filled with strange magic, these were my mentors, my brothers, my friends.Many of the films discussed herein provide experiences that will touch you in ways that stimulate, amuse and disturb—they leave marks. They clearly have done so to the authors in this collection and if you haven’t seen them, be prepared to be newly wounded. If you are already an initiate, these reviews≥ 75 years old (n = 15,285) increased by a rate of 19.0% from 2001, thus representing the highest increase observed in the subgroup analyses. Patients ≥ 85 years old (n = 29,308; 5661 men and 23,647 women) accounted for 37% of overall fractures among members of the population ≥ 65 years old (data not presented). As shown in [Table 2](#t2-cia-7-575){ref-type="table"}, hospital costs were 467 million Euros in 2005 (+25.2% compared to 2001), with rehabilitation costs reaching 532 million Euros in the same year (+27.0% compared to 2001). Pooling all data together, hospitalizations due to hip fractures in the elderly resulted in expenditures of approximately 6.8 billion Euros over the 5-year period (including both hospital and rehabilitation costs).

The total hospitalizations for hemorrhagic and ischemic strokes (including TIA) were


in the youngest age group, 14.3% and 17.5% in people aged 65--74, and 31.8% and 36.3% in the oldest subgroup, respectively. It should be noted that among AMI patients ≥ 75 years old, the number of women hospitalized was always higher than the number of men, while almost 5000 AMI hospitalizations per year involved people under 45 years old (data not shown).

Overall hospitalization costs incurred for AMI admissions and treatment for adults ≥ 45 years of age ranged between 305 million Euros in 2001 and 370 million Euros in 2005 ([Table 6](#t6-cia-7-575){ref-type="table"}), with an average cost of 3142 Euros per patient in the latter year. Rehabilitation costs following AMI were estimated at between 437 million Euros in 2001 and 525 million Euros in 2005 (an increase of 20.1%to that of strokes and higher than that of AMI, both in terms of hospitalizations and health care expenditures.

**Disclosure**

The authors report no conflicts of interest in this work. Disclosures concerning the past 5 years include: PP has received grants for consulting/speaking by Sanofi-Aventis, Amgen-Dompè, Servier, and Eli-Lilly. AM, MG, AM, AB, RG, RDB, LR, CG, FG, MLB, LM, DD, and GI have received research grants and funding for consulting/speaking by Merck, Sanofi-Aventis, Novartis, Stroder, Servier, Ely Lilly, Roche, Nicomed, and Amgen Dompè. AA, GC, CN, GM, MS, DD, MB, VM, SM, MG report no conflicts of interest.

![Rehabilitative path of hip-fractured patients.](cia-7-575f1){#f1-cia-7-575}

![Number of hospitalizations following hip fractures in elderly people (\>65 years old) versus strokes (both hemorrhagic and ischemic), TIA, and AMI occurring in the whole adult population (Italy


2001--2005).\
**Abbreviations:** TIA, transient ischemic attack; AMI, acute myocardial infarction.](cia-7-575f2){#f2-cia-7-575}

![Estimated direct hospital costs following hip fractures in elderly people (\>65 years old) versus strokes (both hemorrhagic and ischemic), TIA, and AMI occurring in the whole adult population in Italy between 2001 and 2005.\
**Abbreviations:** TIA, transient ischemic attack; AMI, acute myocardial infarction.](cia-7-575f3){#f3-cia-7-575}

######

Number of hospitalizations due to hip fractures in the elderly Italian population (≥65 years old) by age group and sex (Italian Ministry of Health national hospitalization records, 2001--2005)

  Age group (years)   2001     2002     2003     2004     2005                       son of Zechariah, the son of Amariah, the son of Shephatiah, the son of Mahalaleel, of the children of Perez;

Neh 11:5 And Maaseiah the son of Baruch, the son of Colhozeh, the son of Hazaiah, the son of Adaiah, the son of Joiarib, the son of Zechariah, the son of Shiloni.

Neh 11:6 All the sons of Perez that dwelt at Jerusalem were four hundred threescore and eight valiant men.

Neh 11:7 And these are the sons of Benjamin; Sallu the son of Meshullam, the son of Joed, the son of Pedaiah, the son of Kolaiah, the son of Maaseiah, the son of Ithiel, the son of Jesaiah.

Neh 11:8 And after him Gabbai, Sallai, nine hundred twenty and eight.

Neh 11:9 And Joel the son of Zichri was their overseer: and


in Syria win the day, he argued, the U.S. will be playing right into Assad’s hands.

“It’s obvious that Bashar al Assad’s strategy is to present us with a choice of ISIS or him so that eventually we will choose him,” said McCain.

In Iraq, the United States has begun to deliver troops and aircraft to help the embattled government in Baghdad. Iran and Russia are supplying planes and forces of their own. And in the meantime, Assad’s planes are delivering air strikes on Iraq. To McCain, that amounts to an American alliance with those countries, whether that was intentional or not. (To be clear: McCain is also for providing military assistance to Baghdad; he’s just for hitting ISIS in Syria at the same time.)

“I don’t think the administration believesNear East Policy.

“Our inability to deal with ISIS even in Iraq, combined with a lack of working with moderates in Syria, allowed ISIS to fester,” he said. “Now that has led to not only a full-blown crisis but has greatly harmed our ability to get a solution to the Syrian civil war in general.”


fried foods and chips.

The U.S. Food and Drug Administration (FDA) announced a new regulation in 2003 that mandated the labeling of trans fat content in an entry, positioned immediately below the saturated fat declaration in the nutrition facts panel. In preparation for the January 1, 2006 labeling deadline, margarine and food shortening manufacturers contemplated and implemented the various alternative technologies available to them, in anticipation of the expected increase in demand of reduced-trans fat and zero-trans fat foods.

However, the alternative technologies such as blending with tropical oils and interestification have their drawbacks. For instance, blending of polyunsaturated vegetable oils with tropical oils usually results in a semihard fat that does not require hydrogenation, but is high in saturated fats. Interestification technology, on the other hand, is both acontent of trans fats in partially hydrogenated fat by more than 85 percent.

"As such, some of Bunge's commercially available shortenings and margarines have less than 4 percent trans fat by weight," adds Kee. "In addition to the specially hydrogenated products, Bunge also offers trans fat free options that utilize modified canola seeds and soybeans supplied by Dow Agrosciences and DuPont, which have modified fatty acid profiles and do not necessitate partial hydrogenation."

In line with its commitment to providing premium and high-quality edible oils and fats, Bunge plans to continue with its R&D activities so as to develop oils and food products that meet the changing needs of their customers and consumers.

For its timely and path-breaking innovation, Frost & Sullivan is proud to present Bunge Oils with the 2008


You can’t go outside (or online) today without hearing about some tired political issue being brought up, again, along with some generic, over-generalized, judgmental sentiment.

“Gun laws are so screwed up in this country. Everyone who has one is a murderer and should be ashamed of themselves!”

Or

“Illegal immigration is the worst because ‘Mexicans’ keep coming over our boarders and stealing our jobs. Anyone who enables that is a job-stealer (or terrorist sympathizer) and should be ashamed of themselves!”

So how do we respond to those claims? How do we engage in the default political argument at hand?

Most people seem to pick their side and join in, judging the supposed perpetrator of whatever the issue is. For one, that’s a natural impulse — and, for two, it is very easy tostructural error is an issue "for another day" that the Supreme Court may address to establish a rule for innumerable cases in the future. See 128 S.Ct. at 747.
Smith is quite a different matter. The standard for constitutional insufficiency of evidence is established by Jackson v. Virginia, 443 U.S. 307, 319, 99 S.Ct. 2781, 61 L.Ed.2d 560 (1979). There are infinite potential scenarios in which the evidence may be insufficient to convict; the standard is simply whether "any rational trier of fact could have found the essential elements of the crime beyond a reasonable doubt." Id. A decision by the Supreme Court that, under a particular set of facts, the constitutional Jackson standard was or was not met, provides no guide for future decisions addressing different facts. Thus


Q:

The best PHP search engine-friendly method

What method can you recommended for creating search engine-friendly URLs? When coding in PHP that is. Ideally I would like something like:
http://www.example.com/article/523544
So it doesn't display the file it's opening (eg article.php)

A:

It is quite necessary to generate a SEO friendly URL's so that most of the Search engines can easily index it.And the most interesting part with it that URL can easily correlate to the Page Content and the User can generate a Pretty URL as per the keywords he want to rank the page on different Search Engines(e.g. google.com,google.co.in,bing.com)
The best example to have Pretty Links  is on Wordpress.It actually stores the Dynamic Page URL's in the Database itself.And when the Pretty Ur is being called,internally the htaccess is called and it redirectsBrotherhood gains official political legitimacy for first time in its 80 years

Published: 06.07.11

Egypt's Muslim Brotherhood's political party was declared legal by Cairo Tuesday, the state news agency MENA said.

The achievement is the movement's first since its inception, eight decades ago. "The commission on party affairs has given its approval for the formation of the Freedom and Justice Party," MENA said.

The Muslim Brotherhood was officially illegal but mostly tolerated during the rule of president Hosni Mubarak, ousted in a popular revolt on February 11. It was set up in 1928 and an official ban imposed in 1954, over its suspected involvement in a series of political assassinations in the 1950s, including an attempt on the life of Egypt's first republican president, Gamal Abdal Nasser.

As the best-organized political movement in


Q:

How do you run example code snippets with html output from gae?

The following code comes from here. How am I supposed to see the results? Can I use the GAE interactive console somehow, or do I need to create a whole app with an app.yaml etc and run it in the gae launcher? I am particularly interested in snippets with html.
import datetime

from google.appengine.ext import webapp

class MyRequestHandler(webapp.RequestHandler):
    def get(self):
        self.response.out.write("")
        self.response.out.write("
Welcome to the Internet!
")
        self.response.out.write("")

        expires_date = datetime.datetime.utcnow() + datetime.timedelta(365)
        expires_str = expires_date.strftime("%d %b %Y %H:%M:%S GMT")
    Optical coherence tomography (OCT) is a technique for high-resolution depth profiling of a sample below the sample surface. In recent years, swept source optical coherence tomography (SSOCT) systems have demonstrated superior imaging speed, imaging range, and image quality. The key technology element of SSOCT systems is the wavelength swept laser source. The MEMS-tunable vertical cavity laser (MEMS-VCL) has proven to be an important key wavelength-swept source for SS-OCT at 1300 nm and 1050 nm, as described, for example in (I. Grulkowski, J Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment, and full-eye imaging using ultra-high speed swept source OCT with vertical cavity surface-emitting lasers,” Biomedical Optics Express, vol. 3, no. 11, pp. 2733-2751).


1 January 1998 and 31 October 2012, as this was the period the HES data were available for at the time of writing. Patients who had a VTE event were identified. Patients were excluded if:Under 18 years of age at first cancer diagnosisHad a VTE diagnosis in a hospital admission prior to the cancer admission

Data were analysed separately for the 24 most common cancer sites (based on 2007 UK incidence data). Cancer sites not included within these were categorised as 'Other'. 'Unknown primary' site consisted of metastatic cancers with no known primary cancer site (C77--C80). Cancer site classification was based on the first occurring cancer, and the corresponding date was assumed to be the date of diagnosis (termed index date from this point onwards). Ethical approval was given bywho did not undergo treatment (*p* \< 0.05 for all instances).Table 4First VTE event within 6 months from discharge (%) stratified by cancer site and chemotherapyCancer siteNo. of people alive and no VTE during hospitalisationChemotherapyVTE%No chemotherapyVTE%Breast485,009138,77618711.35346,23317720.51Lung278,18271,15523893.36207,02740471.95Bowel364,48996,57718531.92267,91237821.41Prostate335,23117,6871801.02317,54420110.63Non-Hodgkin lymphoma113,98960,49511651.9353,4949901.85Malignant melanoma82,4454088200.4978,3571350.17Bladder217,21732,4182910.90184,79912560.68Kidney60,7554458611.3756,2976631.18Oesophageal79,81222,78610634.6757,02613162.31Stomach66,31414,9167264.8751,39811602.26Pancreatic52,29612,0156255.2040,28112903.20Leukaemia86,64823,9572871.2062,6916411.02Uterus68,51676151461.9260,9015590.92Ovarian57,16228,2596132.1728,9037012.43Oral62,78412,0801140.9450,7042640.52Brain55,10767261352.0148,38112182.52Multiple myeloma48,94418,1753481.9130,7696852.23Liver36,48552281552.9631,2576282.01Cervix30,59676511772.3122,9452821.23Laryngeal22,8792711150.5520,168710.35Testicular22,48191191031.1313,362980.73Bone/connective tissue26,4904231781.8422,2592150.97Thyroid21,36871730.4220,651530.26Mesothelioma17,35049081202.4412,4422291.84Other site87,85336,9204761.3050,9337141.40Unknown163,39025,09511284.49138,29528942.09Total2,943,792668,76314,1422.112,275,02927,6741.22

VTE rates by cancer site and timing from index date {#Sec14}
---------------------------------------------------

For all cancer sites, the absolute rate of VTE was higher during hospitalisation compared with rates in the first 6 months following discharge. In the first 6 months following discharge, the cancer sites associated with the highest rates were pancreatic (11.9 per 1000 person-years; CI 11.3--12.4), oesophageal (7.8; CI 7.4--8.1) and lung (6.8; CI 6.7--7.0). The overall rate of VTE was 3.34 per 1000 person-years (95 % CI 3.31--3.37). (Additional file [3](#MOESM3){ref-type="media"}: Figure S3).

Discussion {#Sec15}
==========

Main findings {#Sec16}
-------------

We found that more people developed VTE in


confounders such as stage of disease and comorbidity which have been shown to be associated with risk of VTE. These variables could explain why patients with certain cancer types, and those undergoing chemotherapy, have a higher risk of VTE than others \[[@CR14], [@CR20]\]. Finally, as in the case of other studies, it is likely that we have underestimated the number of people receiving chemotherapy as we have only included therapy during hospital admission.

Comparison with other studies {#Sec18}
-----------------------------

This current study is consistent with the findings of previous work, that pancreatic cancer is associated with the highest risk of VTE amongst patients hospitalised for cancer \[[@CR16]--[@CR18]\]. With respect to the risk of VTE during hospitalisation, Stein et al. \[[@CR17]\] found a similar finding of 2 % risk of VTE in patients& Chris O’Brien are Lehigh grads, so you know what that means:

1. They know how to party

2. They know how to throw a tailgate

3. And they definitely know about rivalries ahemmmm, Stubhub…

To join the party, buy your Lehigh Tailgate ticket(s) here for $59.

Please note this does not include a ticket to the game, however tickets can be purchased here on TickPick.

Lehigh Lafayette Yankee Stadium Tailgate Details

11:30am – All You Can Eat & Drink Tailgate

The tailgate will be at The Deegan Parking Lot, which is walking distance near Yankee Stadium. No need to worry about packing coolers, solo cups or speakers, this is an all you can eat & drink, affair. DJ Teddy Brown aka Da Bringa (a Lehigh grad) will be providing tunes, and Chumley’s BBQ (see menu


which all MINSS techniques should be measured. Although the initial outcomes of cryoablation and radiofrequency ablation (RFA) are encouraging, long-term studies are necessary to confirm lasting efficacy. The optimal modality for tumour targeting, monitoring therapy, and follow-up remains to be determined. These ablative techniques should be reserved for carefully selected patients, the data should be prospectively accrued, and the long-term cancer cure rates should be compared with the reference standard. Promising long-term data are available for cryoablation. RFA is still considered developmental, and instances of incomplete cell kill, despite nonenhancement, are concerning. Other modalities are still experimental.               errors::InvalidArgument(
                    "Inputs (L and grad) must have the same shape."));
    OP_REQUIRES(context,
                TensorShapeUtils::IsSquareMatrix(input_matrix_shapes[0]),
                errors::InvalidArgument("Inputs must be a square matrices."));
  }

  TensorShapes GetOutputMatrixShapes(
      const TensorShapes& input_matrix_shapes) const final {
    return TensorShapes({input_matrix_shapes[0]});
  }

  void ComputeMatrix(OpKernelContext* context, const ConstMatrixMaps& inputs,


from this model.

The three upper panels in Figure \[fig:fig6\] show the large scale properties of model `s00`. The location of the electron scattering photosphere is indicated by the yellow contours. The radiation temperature in the last panel confirms the discussion in the previous paragraph. For a wide range of angles surrounding the equator, $T_r\sim 10^{4.4}$ K (purple color), so the escaping radiation here will be in the optical/UV band. For a range of angles closer to the pole, the temperature is around $10^5$K (light blue). This region corresponds to the slow-moving wind. Finally, close to the pole, the temperature goes up to $\sim10^6$K. This is the jet. How much radiation each of these three zones contributes to the observed spectrum depends on the gas density and temperature (atBH of the same spin.

Figure \[fig:fig11\] is similar to Figure \[fig:fig5\], but now refers to model `m09`. The central region of the jet ($\theta=9^\circ$) is accelerated to a fairly large Lorentz factor $\Gamma \sim 5-6$, while at larger angles from the pole the Lorentz factor drops off rapidly. Motivated by the observation that the late-time radio emission from J1644 is likely due to a two component jet [@Berger2012; @Wang2014; @Mimica2015; @Liu2015], we define two jet regions. We call the higher Lorentz factor zone the jet ‘core’ and the rest of the jet the ‘sheath’, defining the boundary between the two to be located at $\Gamma = 2$ (following @Mimica2015). With this definition, the boundary between the core and the sheath is at $\theta_{j,c} \sim 15^\circ$, while the boundary


is quite similar to that of `m09`. At larger angles, the photosphere in model `m09` extends to radii well outside the torus. This model ejects a lot of gas in the wind which forms an optically thick region surrounding the jet. There is no comparable feature in model `s00`.

The jet in `m09` has a radiative flux that is roughly 2-3 orders of magnitude greater than the flux in `s00`. Also, the jet covers a much wider angle. Whereas `s00` showed hardly any radiation energy density outside of the optically thick regions, `m09` carries a significant amount of radiation energy density throughout the jet, signifying that photons escape more easily through the funnel and that synchrotron and inverse Compton processes are more effective at transferring energy from the gasdistant observers at different viewing angles. Spectra computed for the two non-jetted SANE models `s00` and `s09` are qualitatively quite similar, and can be decomposed into four peaks, one in the infrared (IR), one in near-UV, one in far-UV/soft X-rays and one in hard X-rays. The first peak (near-UV) is from the $T_r\sim 10^{4.4}$K photosphere of the torus, the second (far-UV) is from hotter gas ($T_r\sim 10^{5.5}$K)in the funnel wall/wind, and the third peak (hard X-rays) is from the hottest gas, which is in the jet. A tail of very high energy gamma-ray emission comes from Compton-upscattered radiation by hot gas, but this component is extremely weak. Thermal synchrotron emission from the jet produces the low luminosity ($< 10^{38}$ $\rm{erg\ \, s^{-1}}$) peak in the IR.

In models `s00`


of increasing the spin of the BH clearly leads to the injection of more energy into the jet and a higher radiative efficiency; however, the lack of a jet in their model suggests $a_* > 0.8$ is needed to produce a truly relativistic jet. We should note that it is possible that the lack of an ultra relativistic jet in @Dai2018 is due to inadequate numerical resolution.

We computed model spectra from our simulations and compared them with observational data on jetted and non-jetted TDEs. We found surprisingly good qualitative agreement. We did note some quantitative discrepancies, which call for more detailed study, but the overall conclusion is that the super-Eddington models described here provide a promising explanation of TDE phenomenology, at least near the peak of these outbursts.

Thethis work. We thank Aleksander S[a]{}dowski for assistance with the KORAL code, and Andrew Chael, Pawan Kumar, and especially Wenbin Lu and the referee for useful comments and suggestions. This work was supported in part by NSF grant AST-1816420, and made use of computational support from NSF via XSEDE resources (grant TG-AST080026N) and NASA via High-End Computing (HEC) resources. This work was carried out at the Black Hole Initiative at Harvard University, which is supported by a grant from the John Templeton Foundation.

[99]{}

Abramowicz M. A., Czerny B., Lasota J. P., Szuszkiewicz E., 1988, ApJ, 332, 646

Aleksi[ć]{}, J., Antonelli, L. A., Antoranz, P., et al. 2013, , 552, A112

Alexander, K. D., Berger, E., Guillochon, J., Zauderer, B. A., & Williams, P. K. G. 2016, , 819, L25

Aliu, E., Arlen, T., Aune, T., et al. 2011, , 738, L30

Auchettl,


stored in a memory of the microcomputer. The gas in contact with the sensor can be detected because of the resulting difference spectra. The patent further discloses that the best performance of the invention is likely to be conducted between frequency ranging 100 MHz to 500 MHz wherein the resonance may happen.
The '401 Lewis patent discloses arrays of chemical sensors for detecting analytes in fluids. The sensors include first and second conductive elements electrically coupled to and separated by a chemically sensitive resistor which provides an electrical path between the conductive elements. The resistor includes a plurality of alternating nonconductive regions made of a nonconductive organic polymer and conductive regions made of a conductive material transverse to the electrical path. The resistor further provides a difference in resistancenewspapers and television stations owned by the E.W. Scripps Co. The computer algorithm that can spot serial killings within FBI computer files was developed as part of that project. To download a copy of the award-winning project "Murder Mysteries" click here.MAP also makes available the original FBI master files from which most of these records were obtained. To download the FBI's very large (6.8 gigabyte) master data files of the Uniform Crime Report's "Return A" showing summaries of total homicides committed and cleared through arrest for the years 1960 to the present (in ZIP archive format with the necessary data dictionary) click here. (Note: These records generally require sophisticated software like R, SAS or SPSS.)To download the 137-megabyte data files of the FBI's original Supplementary Homicide Report showing


WASHINGTON (Reuters) - U.S. President Donald Trump on Wednesday nominated the chief executive of AccuWeather Inc to head the government’s meteorological agency that monitors the climate and issues daily weather forecasts.

Trump nominated Barry Myers, CEO of privately owned weather forecasting company AccuWeather, to head the National Oceanic and Atmospheric Administration, part of the U.S. Commerce Department.

Myers’ name was first floated for the position in January, and the Washington Post reported in May he had emerged as the front runner. AccuWeather did not immediately respond to a request for comment on Wednesday.

The White House said Myers has run AccuWeather since 2007 and over the last decade the “company has experienced its highest grossing years, and its largest global web and mobile audience growth. He is one of the world’sleading authorities on the use of weather information.”

AccuWeather, based in State College, Pennsylvania, was founded by Myers’ brother Joel Myers.

The Trump administration proposed in May cutting the NOAA budget by 17 percent to $4.8 billion, including cutting $230 million for grant and education programs. NOAA provides daily and long-term weather forecasts for agricultural planning and emergency response to severe weather like hurricanes.

In July, Senator Bill Nelson, a Democrat, raised concerns about the nomination. AccuWeather in 2005 worked with then-Senator Rick Santorum to back an unsuccessful proposal that would have limited dissemination of National Weather Service forecasts on websites.

“Many Americans have come to rely on forecasts issued daily by the National Weather Service,” Nelson said. “From storm tracking to drought forecasts, this information is critical to protecting life, property


smear microscopy using a dye specific for the mycobacterial cell wall as a probe for the bacilli. This is fairly insensitive and probably misses as many as half of the cases of pulmonary TB (and pretty much all extrapulmonary TB cases). Sputum culture is much better, with a sensitivity estimated at \~90%, but culture is both difficult and slow, requiring specialized facilities and several weeks of incubation. More modern approaches that rely on cultivation in broth instead of solid media and use automatic detection methods are more rapid but require specialized equipment and are not available in many areas where TB is endemic ([@B28]).

Clearly, DNA amplification would be more rapid. Many "home brew" approaches had uneven sensitivity, probably because it is difficult to release DNA from mycobacteria withlipids, including many that are not made by any other bacteria. Much of the metabolic machinery is devoted to lipid biosynthesis and degradation, and several lipids play key roles in pathogenesis.

Most mycobacteria are environmental organisms that are found in water and soil. Habitats such as peat bogs are particularly rich sources of mycobacteria. Although most are not important human pathogens, many can infect other hosts as diverse as frogs and birds. And most mycobacteria share the ability to survive inside environmental phagocytes such as amoebas ([@B38], [@B39]). Thus, the capacity of *M. tuberculosis* to survive within macrophages might be derived from its ancestors.

**How diverse is *M. tuberculosis*?**

*Not very. But perhaps enough to have a clinically significant impact*.

It comes down to whether you are a splitter or a joiner. *M. tuberculosis* strains


expresses a set of genes that encode specific virulence factors. These are often toxins or specialized secretory systems that allow the pathogen to modify the responses of host cells, either killing them or subverting their defenses. But this paradigm simply doesn't work for *M. tuberculosis*. As an obligate pathogen, it never has to adapt to the host---it is always prepared for the host environment. Although *M. tuberculosis* has a large complement of regulators, unlike in many Gram-negative pathogens, there are no master regulators of virulence determinants.

Instead, the entire physiology of *M. tuberculosis* is geared for survival in the host. Because of this, it is quite difficult to define factors that are specifically designed for virulence; instead it has adapted factors it has inherited to take advantage of the host environment. Thisregimens that include newly introduced drugs can shorten therapy to as little as 6 weeks ([@B88]), though it will take human trials to determine the predictive power of the mouse model.

Several new drugs are either being developed or repurposed for TB. These drugs include antibiotics that are used in other infections, such as linezolid ([@B89]), and new classes of drugs, such as bedaquiline ([@B90]) and delamanid ([@B91]), with novel mechanisms of action. Each of these drugs has been shown to improve the response of drug-resistant TB, allowing shorter courses of treatment when added as single agents to otherwise poorly performing regimens ([@B89], [@B92][@B93][@B94]). Mouse studies have suggested that combining some of these antibiotics results in more rapid cure, a hypothesis that is currently being tested in humans.

**Can we do


in the context of PD therapeutics; susceptible variants or genes have been shown to be associated with the appropriate therapeutic dosage of L-dopa or relevant motor complications. Genetic variants, such as *DRD3* G3127A in the dopamine receptor (DR) gene have been shown to be involved in L-dopa-induced dyskinesia (Comi et al., [@B14]). G2385R in *LRRK2* was previously found to be significantly associated with motor complications in female PD patients (Gao et al., [@B27]). Our analysis demonstrated that G2019S or G2385R carriers tend to develop motor complications with significant differences, consistent with higher LEDD, relative to non-carriers (Cacabelos, [@B9]). As motor complications are known to severely damage the life quality of PD patients, it is our duty, as clinicians, to minimize complications, such as dyskinesia and motor fluctuations. Ourphenotypes of PD. Therefore, more comprehensive data are needed to perfect this meta-analysis. Second, heterogeneities existed among original studies in our pooled analysis; with a greater availability of original articles, it is advisable to adjust the pooled results and aim for more robust evidence. Third, co-occurrence and interaction between the factors could not be analyzed in the present meta-analysis, which may have confounded the results.

Conclusion {#s5}
==========

Clinical heterogeneity in *LRRK2*-associated PD among different variants, especially for G2019S and G2385R, was found to occur. We observed no distinct clinical features for R1628P or R1441G. The prominent clinical features of *LRRK2-*G2019S-related PD patients were female sex and higher rates of EOPD and family history. Further, G2019S carriers were less likely to be depressive and have olfactory dysfunctions, had better response to


Sims before getting into the industry themselves. With their next game, Tiny Tycoons, Bisceglia wanted to use the insight of Wright’s years of experience to craft the most expansive and location-centric simulation experience that he could.

In the free-to-play Tiny Tycoons, players are challenged to own and manage a winning establishment from a number of business properties that reflect upon the actual real-world locations around them. Bisceglia was able to meet with Wright several times over the last year or so, where the gaming expert acted as a friendly advisor to The Tap Lab in helping to steer the direction of Tiny Tycoons, and to put changes in place that would open up the game world on a more real-life, global level. Wright’s main advice involved shifting Tiny TycoonsBig two personality and big three mate preferences: similarity attracts, but country-level mate preferences crucially matter.
People differ regarding their "Big Three" mate preferences of attractiveness, status, and interpersonal warmth. We explain these differences by linking them to the "Big Two" personality dimensions of agency/competence and communion/warmth. The similarity-attracts hypothesis predicts that people high in agency prefer attractiveness and status in mates, whereas those high in communion prefer warmth. However, these effects may be moderated by agentics' tendency to contrast from ambient culture, and communals' tendency to assimilate to ambient culture. Attending to such agentic-cultural-contrast and communal-cultural-assimilation crucially qualifies the similarity-attracts hypothesis. Data from 187,957 online-daters across 11 countries supported this model for each of the Big Three. For example, agentics-more so than communals-preferred attractiveness, but this similarity-attracts effect


on inflammation, as was seen with adenoviral overexpression in rabbit AIA \[[@B41],[@B42]\]. The disadvantage of adenoviruses is the episomal nature of the viral genome, which is lost during cell division, resulting in short-term transgene expression. A major limitation is the acquired immune response against adenovirus serotype 5 in most humans, and seven out of 10 samples of RA synovial fluid contained neutralizing antibodies \[[@B43]\].

Viruses such as the herpes simplex virus (HSV), adeno-associated viruses (AAVs) and lentiviruses are thought to integrate into host chromosomes, and therefore potentially could have long-term expression, even in proliferating synovium. Current data suggest that the recombinant AAV remains episomal located in cells as the deleted AAV replication (Rep) proteins normally facilitates genomic integration. Injection of a replication deficient HSV (T/0-) encoding IL-1Ra into rabbitfor regulated expression of viral IL-10 -- before mice were immunized. Doxycycline administration starting 23 days after immunization significantly reduced clinical, radiological and histological CIA scores. The study conducted by Perez and coworkers \[[@B55]\] used the tetracycline-dependent transcriptional silencer (tTS) for viral IL-10 regulation. The two plasmids were intramuscularly injected and electrotransferred before the onset of disease, and doxycycline treatment resulted in a significant inhibitory effect on CIA. Recently, Gould and colleagues \[[@B56]\] used an improved vector system with the rtTA (tet-on) expression and transgene expression, both under control of the tetO promoter in a head--tail configuration on one plasmid. The plasmid was electrotransferred intramuscularly in order to yield expression of a dimeric TNF receptor 2, and it was found that prophylactic treatment significantly reduced CIA hindpaw swelling


the untreated front paws \[[@B100]\]. In our experiments we could not detect IL-10 or IL-1Ra in the blood circulation, and others found no evidence of systemic overflow of locally synthesized transgene proteins (IL-4, soluble IL-1 receptor I, soluble TNF receptor, IL-1Ra) \[[@B15],[@B37],[@B39],[@B96]\]. A likely explanation for the remote protection conferred by local gene therapy is the reduction in local production of proinflammatory cytokines, thereby reducing their circulating levels and abolishing a sensitizing effect on naïve joints.

A conflicting finding was the protection of the ipsilateral hind paw by adenoviral overexpression of IL-10, which was seen in the absence of a local anti-inflammatory response in the knee \[[@B37]\]. There is compelling evidence that this protective remote effect could also be accounted for by immune modulation. Transfer of soluble IL-1 receptorintermolecular hydrogen-bonded network among phospholipid molecules in association with the liberation of hydrated water molecules on membranes and also alter the orientation of the P--N dipole of phospholipid molecules, resulting in an increase in membrane fluidity \[[@B17]\]. However, the membrane lipid-interacting theory has been criticized as to whether local anesthetics can affect biomembranes at clinically relevant concentrations, whether local anesthetic molecules in charged form can interact with lipid bilayers, and whether local anesthetics like bupivacaine and ropivacaine can stereostructure-specifically act on lipid membranes to show the potency different between stereoisomers. These subjects are discussed in Sections [4](#sec4){ref-type="sec"}, [5](#sec5){ref-type="sec"}, [6](#sec6){ref-type="sec"}, and [8](#sec8){ref-type="sec"}.

4. Membrane Interaction at Clinically Relevant Concentrations {#sec4}
=============================================================

The concentrations of lidocaine typically used in the clinical setting for dentistry are 1--3% (w/v) \[[@B14]\]. At 0.03--0.08 times these concentrations,


investigated by measuring fluorescence polarization with DPH in previous studies \[[@B19], [@B20], [@B23]\]. The degrees of local anesthetics-induced changes in DPH polarization correspond to the functional changes of lipid bilayer membranes and membrane-embedded proteins \[[@B23], [@B26], [@B27]\], possibly producing the pharmacologic and toxic effects of local anesthetics.

Membrane-acting drugs accumulate in lipid bilayers and their local membrane concentrations are much higher than their concentrations in the bulk aqueous phase to show the intramembrane concentrations being hundreds of times higher than the aqueous concentrations \[[@B28]\]. Their concentrations in lipid bilayer membranes are consistent with the properties of local anesthetics to interact with biomembranes and modify the membrane fluidity at clinically relevant concentrations. While general anesthetics interact with biomembranes as well as local anesthetics do, they show the water-membrane interfacial concentrationsof cases \[[@B37]\].

6.2. Verification of Conventional Acidosis Theory {#sec6.2}
-------------------------------------------------

Acidic metabolites like lactic acid are increasingly produced and concentrated in inflamed tissues, thereby inducing the acidosis that lowers the tissue pH at least the order of 0.5--1.0 pH unit \[[@B38], [@B39]\]. The p*K*a values of almost all of local anesthetics in dental use are larger than 7.5 at 37°C \[[@B1]\], so a greater proportion of administered drugs exist as positively charged molecules in and near inflammatory lesions. Because cationic molecules are much less in membrane permeability and membrane interactivity under acidic conditions, the local anesthetic effects should be remarkably decreased, leading to the mechanistic theory that the local anesthetic efficacy is reduced by inflammatory tissue acidosis. This acidosis theory has been conventionally accepted due to its theoretical simplicity and understandability


cardiotoxic effects of local anesthetics. A crucial role of anionic phospholipids like cardiolipin in the interaction between local anesthetics and membrane lipids may also lead to the therapeutic possibility for local anesthetic cardiotoxicity \[[@B56]\] as described in [Section 7.3](#sec7.3){ref-type="sec"}.

7.3. Treatment of Cardiotoxicity with Lipid Emulsion {#sec7.3}
----------------------------------------------------

Although newly introduced ropivacaine and levobupivacaine are less toxic, they still cause the life-threatening events, so the cardiotoxicity of long-acting local anesthetics remains an important problem. The property of local anesthetics to hydrophobically interact with or selectively bind to membrane lipids may provide a novel strategy for treating their cardiotoxicity. Weinberg et al. \[[@B57]\] reported that the treatment with a lipid infusion shifted the dose response to bupivacaine-induced asystole of rats and dogs to increase the bupivacaine lethal doses. Since then, the rapidanother chiral molecule in biomembranes. Membrane cholesterol contributes to such an enantioselective interaction by increasing the chirality of lipid bilayers. The stereostructure and membrane interactivity relationship supports the clinical use of *S*(−)-enantiomers to decrease the adverse effects of local anesthetics on the cardiovascular system.

9. Interaction Preference for Membrane Microdomain Lipid Rafts {#sec9}
==============================================================

In the late 1990s, the fluid mosaic model of Singer and Nicholson for biomembranes was evolved to a more sophisticated concept, especially concerning the membrane lipid composition and molecular organization. It has become clear that biomembranes are not the simple bilayer structure with uniformly distributed lipids but organized into phase-separated microdomains, called lipid rafts, with specific lipid components and molecular dynamics that differ from the surrounding liquid crystalline phase and bulk membranes \[[@B101]\]. In lipid rafts, cholesterol


any raft model membranes showed neither drug structure dependence nor stereoselectivity in membrane interaction, leading to the conclusion that the mechanistic relevance of membrane microdomain lipid rafts to local anesthetics is questionable at least in their effects on raft model membranes. Bandeiras et al. \[[@B110]\] also reported that lidocaine interacted with raft model membranes, although its interactivity was weaker compared with nonraft membranes.

10. Anesthetic and Phytochemical Membrane Interaction {#sec10}
=====================================================

10.1. Drug Interaction with Phytochemicals {#sec10.1}
------------------------------------------

While the concomitant use of medicines with medicinal plants or herbs has been increasing in popularity, it potentially causes the beneficial or adverse drug interaction with plant components. Unlike the drug-drug interaction, however, the interaction between drugs and phytochemicals (bioactive chemical substances in plants) has not been extensively investigated despite the possibility of more frequentoccurrence than expected \[[@B111]\]. Various drugs appear to show the antagonistic, additive, and synergistic interactions with phytochemicals \[[@B112]\].

10.2. Capsaicin {#sec10.2}
---------------

Topical or systemic lidocaine therapy is expected to provide a novel management of neuropathic pain symptoms together with enhancing the utility by combining with capsaicin \[[@B113]\]. Capsaicin, 8-methyl-*N*-vanillyl-6-nonenamide, is a pungent component of plants belonging to the genus *Capsicum* such as chili pepper. On the initial application, this phytochemical shows an excitatory effect to produce burning pain and hyperalgesia, whereas with the repeated or prolonged application it shows an inhibitory effect on the receptive terminals of nociceptors. Capsaicin activates a transient receptor potential vanilloid (TRPV1) receptor, which belongs to a family of TRP channels, to exert an analgesic or algesic effect depending on its concentrations \[[@B114]\]. Capsaicin-activating TRPV1 receptor


rout for QX-314 occurs only on nociceptors, the combination of QX-314 or local anesthetics with capsaicin is expected to produce the ideal analgesia affecting pain alone or the pain-restricted local anesthesia preserving motor and autonomic responses \[[@B121]\]. Shin et al. \[[@B122], [@B123]\] found that capsaicin significantly potentiates at 50 *μ*M the rat sciatic nerve block by lidocaine. The cooperative drug interaction with capsaicin also would be useful for increasing and prolonging local anesthetic effects.

Capsaicin acts on lipid bilayers to modify the membrane fluidity as well as local anesthetics and QX-314 \[[@B124]\]. Experimental data show that capsaicin interacts with nerve cell-mimetic membranes to change the membrane fluidity and that the combined use with 50 *μ*M capsaicin additively increases the membrane effects of lidocaine and bupivacaine of clinically relevant concentrations \[[@B125]\]. Capsaicincholesterol, rich in molecular species and chirality, allow the membrane interaction of local anesthetics to be structure dependent and stereostructure selective.

The interaction between local anesthetics and membrane lipids would be associated with both the basic mechanisms for anesthetic and cardiotoxic effects and the clinical features such as the activity and toxicity altered by pathophysiological conditions, the cardiotoxicity varying by structural differences and discriminating between stereoisomers, the utility of a lipid emulsion to treat cardiotoxicity, and the combination with phytochemicals. The interaction with only functional proteins cannot explain all of the pharmacological and toxicological characteristics of local anesthetics nor can the interaction with only membrane lipids. Membrane lipid-interacting theory and membrane protein-interacting theory are complimentary to each other, suggesting the modified lipid-protein interaction mechanism for local anesthetics.

The authors (Hironori


// # Globbing
// for performance reasons we're only matching one level down:
// '<%= config.src %>/templates/pages/{,*/}*.hbs'
// use this if you want to match all subfolders:
// '<%= config.src %>/templates/pages/**/*.hbs'

/* globals module, require */

module.exports = function(grunt) {

  'use strict';

  var settings = grunt.file.readJSON('settings.json');

  require('time-grunt')(grunt);
  require('load-grunt-tasks')(grunt);
  grunt.loadNpmTasks('grunt-assemble');

  // Project configuration.
  grunt.initConfig({

    config: {
      src: 'src',
      tmp: 'tmp',
      dist: 'dist'
    },

    watch: {
      assemble: {
        files: ['<%= config.src %>/{data,templates}/{,*/}*.{md,hbs,yml,json}'],
        tasks: ['assemble']
      },
      sass:config.tmp %>/emails/css/{,*/}*.css',
          '<%= config.tmp %>/images/{,*/}*.{png,jpg,jpeg,gif,webp,svg}'
        ]
      }
    },

    connect: {
      options: {
        port: 9000,
        livereload: 35729,
        // change this to '0.0.0.0' to access the server from outside
        hostname: process.env.HOSTNAME || 'localhost'
      },
      livereload: {
        options: {
          open: true,


but they have plenty of the people version.

They can fight by building — literally, by building better cities. Perhaps more to the point, though, they can fight figuratively, by building city-based identities that are more welcoming to more of us than the exclusive, regressive, grievance-laden UCP 'Albertan' identity that's being forced down our throats.

This is a battle over who we think we are. To fight, Edmonton and Calgary need to give their residents reasons to see themselves, many for the first time, as city people.

Why Canadian cities must fight

Cities are 'creatures' of their provinces thanks to our constitution.

This shouldn't surprise us. The document was written in 1867, when the largest city, Montreal, had roughly 100,000 residents , when Alberta did not exist, and when Edmonton and Calgary weredeal that prevents Ontario's meddling and instead builds collaboration.

It's this exact collaboration that Kenney and the UCP have stripped from their relationship with Edmonton and Calgary, by axing their city charters.

To fight a bully province, Calgary (pictured) and Edmonton must build city identities that offer more than the parochial anger that’s being stoked outside of it. (Leslie Kramer/CBC)

Charters are precisely what's needed to prepare these cities to service close to 80 per cent of the province's population. They offer a fundamental change in governance and funding, from new ways to raise revenue ( payroll, congestion and even sales taxes are all employed in other international cities ) to new rights and autonomy.

Given this fact, should new charters be where Calgary and Edmonton concentrate their effort?

Not yet.

What's needed first


Encrypted bandwidth-efficient backup using the rsync algorithm

Duplicity backs directories by producing encrypted tar-format volumes and uploading them to a remote or local file server. Because duplicity uses librsync, the incremental archives are space efficient and only record the parts of files that have changed since the last backup. Because duplicity uses GnuPG to encrypt and/or sign these archives, they will be safe from spying and/or modification by the server.

The duplicity package also includes the rdiffdir utility. Rdiffdir is an extension of librsync's rdiff to directories---it can be used to produce signatures and deltas of directories as well as regular files. These signatures and deltas are in GNU tar format.

Duplicity is fairly mature software. As any software, it may still have a few bugs, but will work for normalthat many major companies using Vue out there. However, every time I’ve had any issues, it’s usually because I was overthinking it, and I was pleasantly surprised when it really was that easy to implement.”

It becomes obvious that Vue.js is ready for widespread commercial use and will continue to gain popularity even among the “major players.”

6. Ease of integration is the chief advantage of Vue.js

An impressive 81% of developers emphasize ease of integration when it comes to Vue. This very trait of Vue.js was brought up by respondents even more frequently than Vue’s documentation and performance. At the end of the day, it really deserves the Progressive Framework name.

7. More real-life examples in the upcoming cookbook

Although Vue.js was unanimously called amazing, many developers still yearn for better documentation


easy and elegant way, like no other framework before it managed to.

How come Vue is so enjoyable to work with?

Evan You says: “Today, I envision Vue’s goal to be helping more developers enjoy building apps on the Web. I believe that happier developers are more productive, and ultimately create more value for everyone. The goal entails delivering a framework that is approachable, intuitive, and at the same time solid, powerful, and scalable.”

The Final Word

Before we started working with clients who directly requested their apps to be written with Vue, we grew used to talking to businesses who have never heard of it before. But once they got a taste of it, they were impressed with its openness and power and wanted it in their technology stack. Now, companiesBeatings from the North

Monday, October 31, 2011

This is my 100th post on this blog and it could be the last one. But don't worry, if you like following Scandinavian MMA you can now do it even easier at MMAViking.com. Me and Ryan of MMAViking have decided to put our content together on one website that serves a very clear purpose: all about Scandinavian MMA in English on one site.

Thanks to everyone who has read my scribblings over the past three years and I hope you all follow me to the MMAViking.com.

Sunday, October 9, 2011

Beforehand Cage 16's main event fights were seen as final tests for Finnish MMA stars Anton Kuivanen and Tom "Stoneface" Niinimäki who have been patiently waiting for their shot at the major leagues. The wait


years he has managed to take his wrestling and ground game to another level also.

Like Kuivanen, also the Brazilian veteran Thiago “Minu” Meller is far from a one trick pony. Most of his wins have become via submission but Meller is competent on the feet too and has a record of 15-1 in Muay Thai. Meller has snatched eight of his eleven submission wins by guillotine choke. He hunts for his opponents head in the clinch, locks in the arm in guillotine, drops down on his back and applies the choke perfectly leaving his opponents no choice but to tap out. On the feet Meller’s best weapon are the vicious kicks he throws, thanks to his Muay Thai background. Meller is a gutsy and iron chinned fighter whohas never been knocked out and submitted just once. His four career losses have become in the hands of top level talent like current UFC Featherweight Champion Jose Aldo and UFC lightweight contender Rafael Dos Anjos.

Cage Featherweight title bout: Tom “Stoneface” Niinimäki (15-5-0) vs Johnny Frachey (13-8-0), France
Europe’s number two featherweight Tom Niinimäki finally returns to the cage after being almost a full year without an MMA fight. Notable challenger comes in a form of Frenchman Johnny Frachey who tries to give Niinimäki his first loss at Featherweight.

According to information that I’ve receiving, the reason for the layoff was mainly due to no one wanting to fight Niinimäki in the Euro circuit while for some reason major promotions didn’t sign him. During this time Niinimäki however kept himself


able to set the pace as Gunderson begun to fade away. After three rounds of grueling ground fighting, the judges awarded Puhakka with an unanimous decision. This was probably Puhakka’s biggest win ever so it’ll be interesting to see where his next fight will take place.

In the light heavyweight bout Finnish top prospect Marcus “Caveman” Vänttinen dominated France’s Malid Merak. Vänttinen was clearly the stronger fighter and took his opponent down easily from the clinch. On the ground the long limbed Frenchman quickly tried to apply a kimura on Vänttinen but the Finn tucked his hand deep and punished Merak for the rest of the round. In the second round Vänttinen again took his opponent down from the clinch and started raining down elbows and punches. Eventually VänttinenMexico City followed a path of rapid growth in the entire post-WWII period. Carlos Fuentes attempted to capture the essence of this new urban life in one of the first urban novels to be published about this period in Mexico, _La región más transparente_ (1958, _Where the Air Is Clear_ ). In this novel Fuentes was also highly critical of the new ruling class presiding over the Mexican Miracle.

In the 1940s and 1950s, then, writers such as Asturias, Carpentier, García Márquez, João Guimarães Rosa, Fuentes, and a host of others drew upon the venerable tradition of the Latin American writer as social critic, as voice of its indigenous traditions, its historic past and political present and its vast and heterogeneous cultures. In addition, these writers were interested in


participate in the post-Boom, _El recurso del método_ (1974, _Reasons of State_ ) and _Concierto barroco_ (1974, Baroque concert). _Reasons of State_ is Carpentier's contribution to the ever expanding genre of the dictator novel in Latin America. It is a satirical portrayal of an aging Latin American dictator living in France in the early part of the twentieth century. The title of the novel in the original Spanish parodies Descartes.

Cuban Eliseo Alberto has become a renowned writer only recently, having been awarded a prestigious literary prize (Premio Alfaguara de Novela) in 1998. Born in 1951, he has lived in exile in Mexico since the 1990s, after having established a literary reputation with a broad range of creative writing in Cuba. After publishing two novels written in Cuba, henovelists of the time wrote in a more sober tone, and this was the case of Onetti and Viñas, who offer the reader none of Marechal's humor. In Onetti's fiction of the early 1950s— _La vida breve_ and _Los adioses_ (1954, _The Goodbyes_ )—he delves into severe forms of alienation. The protagonists of these works strive for any meaning in life, but eventually are reduced to enduring lives of nothingness. Disillusionment reigns in the always-gray world of Onetti. The protagonist is named Brausen, but he also has alter egos named Díaz Grey and Arce, leaving fixed identities impossible to establish. The characters are equally despondent in _Los adioses_ , and the reader senses the same feeling of futility of Onetti's earlier work. In _Cayó sobre su rostro_ Viñas


set the stage for Fuentes's transhistorical carnival that appeared in the mid-1970s, _Terra nostra_ (1975).

**Campbell, Federico [Biography]** Mexican novelist, journalist, short story writer, translator, and essayist from the border city of Tijuana, he is associated with border writing. Much of his work has to do with politics and power, and his essays _La invención del poder_ (1994, The invention of power) deal with these subjects. Born in Tijuana in 1941, he studied there for elementary school before going to Hermosillo, Sonora, for his high school studies in 1957 and 1958 and then to Mexico City for university-level studies, eventually completing a degree in law. He traveled to the United States and Europe in the early 1960s. He also studied journalism in the United States and was practicing journalismin an educational system that taught only British history and in which the schoolmaster is dismissed for sexual misconduct. Lamming then proceeds to show how the British arranged land sales to deprive the original inhabitants of their traditional rights. The totality of these events leads to the political riots of the 1940s in Barbados and points to the eventual independence of Barbados from Great Britain. The synthesis of personal experience, national history, and political critique make _In the Castle of My Skin_ comparable to novels such as Fuentes's _La muerte de Artemio Cruz_ and several of García Márquez's early novels.

**Indigénisme (Caribbean) [Topic]** The _indigénisme_ of the French Caribbean differs considerably from Spanish American _indigenismo_ and Brazilian _indigenismo. Indigénisme_ was a cultural and political movement of the French Caribbean;


writer Gabriel García Márquez. He was born in Guamo (department of Tolima), Colombia, in 1940. He began writing in the late 1960s and published his first volume of short stories, _Cada viga en su ojo_ (Each branch in his eye) in 1967; he has published two other volumes of short fiction as well as a collection of essays and short fiction, _Literatura y chantaje_ (1973). Sánchez and others who began writing in the late 1960s and early 1970s also became known in Colombia as the "Generation of the Blockade and the State of Siege" because of the blockade against Cuba and the numerous governmental crises in Colombia that caused the central government to regularly declare a state of siege, suspending many normal democratic processes and human rights protections.may be helpful in improving intervention programs and in understanding how clinicians prioritize multiple risk factors in individual patients. The AHP method allows the opinions of HCPs to be investigated, giving appropriate weight to their coherence, background and experience.


III, which permits wiretapping conducted by an "investigative or law enforcement officer in the ordinary course of his duties." 18 U.S.C. § 2510(5)(a)(ii). The district court rejected this argument as a matter of law. Because the County did not record the judges' phone conversations in the ordinary course of its law enforcement duties, and because the district court otherwise acted within its discretion, we affirm the judgment in favor of plaintiffs.

I.

2
In 1994, Greenville County, South Carolina completed construction on its new Detention Center. The Detention Center contained a jail, visitation facilities, and offices for law enforcement and administrative personnel. A separate section of the Detention Center con tained offices and courtroom facilities for city and county judges. This area was known as the Judicial Corridor.

3
While building the newJudicial Corridor.

5
In August 1998, Michael B. Abraham, a City Administrative Judge, began to suspect that his phone in the Judicial Corridor was wiretapped. On September 3, 1998, James McDonald, the jail administrator, confirmed Abraham's suspicions. McDonald informed Abraham that it was not possible for the County to remove the telephone lines in the Judicial Corridor from the recording system. According to McDonald, the recording system was attached to a single trunk line. Since the judges' extensions were part of that trunk line, they could not be individually removed from the system. On September  30, 1998, Greenville County deactivated the Detention Center's entire recording system.

6
Abraham and several other judges subsequently brought suit against Greenville County and four individual defendants in state court under the federal wiretapping statute (Title


. . an investigative or law enforcement officer in the ordinary course of his duties." 18 U.S.C.§ 2510(5)(a)(ii).

9
Protecting the privacy of individuals who use the specified means of communication "was an overriding congressional concern [in enacting Title III]." Gelbard v. United States, 408 U.S. 41, 48 (1972). Title III commands respect for conversational privacy by requiring resort to the same system of warrants and neutral and detached review that has historically been used to safeguard the integrity of the person and of property. See 18 U.S.C. § 2516 (requiring a warrant for electronic eavesdropping not within one of the statutory exclusions). Title III represents an attempt by Congress to establish a system of electronic surveillance subject to rigorous safeguards. It protects an individual from all forms of wiretappingmonitor for law enforcement purposes calls relating to Detention Center inmates and employees. See Amati, 176 F.3d at 955-56 (law enforcement exception applies to detention center's recording of calls to and from police station which captured employees' personal calls); United States v. Van Poyck, 77 F.3d 285, 291-92 (9th Cir. 1996) (law enforcement exception applies to detention center's recording of telephone calls by inmates); United States v. Paul , 614 F.2d 115, 116-17 (6th Cir. 1980) (same). Likewise, we do not suggest that overhearing personal conversations while conducting legitimate wiretapping activ ities violates Title III. Such incidental overhearing is endemic to surveillance. See Amati, 176 F.3d at 956 ("That personal as well as official calls were made on the line is irrelevant; all employees make personal calls on


("[A]n evasive or incomplete disclosure, answer, or response is to be treated as a failure to disclose, answer, or respond."). Plaintiffs' request for documents was clear. The district court did not exceed its discretion in making sure that the County complied with its obligations under the discovery rules. Nor can we fault the district court for seeking full disclosure of documents."Active participation by a district judge in trial proceedings . . . is in itself neither improper nor unfair." Desjardins v. Van Buren Community Hosp., 969 F.2d 1280, 1281 (1st Cir. 1992) (per curiam).

24
Indeed, the district court's belief that the County had not produced all relevant documents was prescient. After the mistrial, the County produced additional documents that were crucial to plaintiffs' case. The most important document was     + "    }%n"
            + "%n"
            + "    /**%n"
            + "     * Returns a custom Logger using the fully qualified name of the Class as%n"
            + "     * the Logger name.%n"
            + "     * %n"


logger name. If null the name of the calling class will%n"
            + "     *            be used.%n"
            + "     * @return The custom Logger.%n"
            + "     */%n"
            + "    public static CLASSNAME create(final String name) {%n"
            + "          + "     * %n"
            + "     * @param marker the marker data specific to this log statement%n"
            + "     * @param msg the message string to be logged%n"
            + "     * @param t A Throwable or null.%n"
            + "     */%n"
            + "


           + "     */%n"
            + "    public void methodName(final Marker marker, final String message, final Object... params) {%n"
            + "        logger.logIfEnabled(FQCN, CUSTOM_LEVEL, marker, message, params);%n"
            + "    }%n"
            + "%n"
            + "    /**%n"
     + "    /**%n"
            + "     * Logs the specified Message at the {@code CUSTOM_LEVEL} level.%n"
            + "     * %n"
            + "     * @param msg the message string to be logged%n"
            + "     */%n"
            + "    public void methodName(final Message msg) {%n"


        + "        logger.logIfEnabled(FQCN, CUSTOM_LEVEL, null, msg, (Throwable) null);%n"
            + "    }%n"
            + "%n"
            + "    /**%n"
            + "     * Logs the specified Message at the {@code CUSTOM_LEVEL} level.%n"
            + "     * %n"
        */%n"
            + "    public void methodName(final Object message) {%n"
            + "        logger.logIfEnabled(FQCN, CUSTOM_LEVEL, null, message, (Throwable) null);%n"
            + "    }%n"
            + "%n"
            + "    /**%n"
            + "     * Logs a message at the {@code


   + "    public void methodName(final String message, final Object p0, "
            + "final Object p1, final Object p2,%n"
            + "            final Object p3, final Object p4, final Object p5) {%n"
            + "        logger.logIfEnabled(FQCN, CUSTOM_LEVEL, null, message, p0, p1, p2, p3, p4, p5);%n"
            + "    }%n"

            + "    /**%n"
            + "     * Logs a message with parameters at the {@code CUSTOM_LEVEL} level.%n"
            + "     * %n"
            + "     * @param message the message to log; the format depends on the message factory.%n"
            + "     * @param p0 parameter to the message.%n"


t);%n"
            + "    }%n"
            + "%n"
            + "    /**%n"
            + "     * Logs a message which is only to be constructed if the logging level is the {@code CUSTOM_LEVEL}"
            + "level.%n"
            + "     *%n"
            + "    /**%n"
            + "     * Logs a message which is only to be constructed if the logging level is the%n"
            + "     * {@code CUSTOM_LEVEL} level with the specified Marker.%n"
            + "     *%n"
            + "     * @param marker the marker data specific to this log statement%n"


message parameters.%n"
            + "     * @since Log4j-2.4%n"
            + "     */%n"
            + "    public void methodName(final Marker marker, final String message, final Supplier<?>..."
            + " paramSuppliers) {%n"
            + "        logger.logIfEnabled(FQCN, CUSTOM_LEVEL, marker, message, paramSuppliers);%n"
            + "   * @param t A Throwable or null.%n"
            + "     * @since Log4j-2.4%n"
            + "     */%n"
            + "    public void methodName(final Marker marker, final Supplier<?> msgSupplier, final Throwable t) {%n"
            + "        logger.logIfEnabled(FQCN, CUSTOM_LEVEL, marker, msgSupplier, t);%n"
            + "    }%n"


    + "%n"
            + "    /**%n"
            + "     * Logs a message with parameters which are only to be constructed if the logging level is%n"
            + "     * the {@code CUSTOM_LEVEL} level.%n"
            + "     *%n"
            + "     * @param message the message to log; the format   + "        logger.logIfEnabled(FQCN, CUSTOM_LEVEL, null, message, paramSuppliers);%n"
            + "    }%n"
            + "%n"
            + "    /**%n"
            + "     * Logs a message which is only to be constructed if the logging level is the%n"
            + "     * {@code CUSTOM_LEVEL} level with the specified Marker. The


       return "the " + levels.get(0).name + " custom log level.";
        }
        final StringBuilder sb = new StringBuilder(512);
        sb.append("the ");
        String sep = "";
        for (int i = 0; i < levels.size(); i++) {
            sb.append(sep);
            sb.append(levels.get(i).name);
            sep = (i == levels.size() - 2) ? " and " : ", ";
    now higher than it's been at any time since the Reagan administration -- another era of Medicaid cuts. That's worse than 83 countries. Worse than Tonga, and Sri Lanka, and Uruguay. Worse than Russia. While Republican legislators made excuses for their cuts, saying that they would give "more flexibility" to governors (like Republican Haley Barbour of Mississippi), the result is scenes like this one.

Jamekia Brown, 22 and two months pregnant with her third child, lives next to the black people’s cemetery in the part of town called No Name, where multiple generations crowd into cheap clapboard houses and trailers. So it took only a minute to walk to the graves of Ms. Brown’s first two children, marked with temporary metal signs because she cannot afford tombstones.

Mississippi isn't the


or therapy purposes [@yamaner]. Mutual interactions between the cells of the array are especially important when the mechanical impedance of cells is relatively low. This is exactly the case for capacitive micromachined transducers (CMUT) which provide a wide band operation in liquid immersion because of its low mechanical impedance [@Park2010]. Mechanics of uncollapsed CMUT cells can be accurately modelled with flexural disks with clamped edges [@Ladabaum98KY]. It was shown that [@koymen12a; @oguz12] it is possible to accurately model an array of CMUT cells using an electrical circuit model coupled to a impedance matrix composed of self and mutual radiation impedances. Self and mutual radiation impedances of equal size CMUT cells in uncollapsed [@senlik10] and collapsed [@ozgurluk] mode can found in the literature.

Porter [@Porter] was the first to quantify the mutual impedance between two identical flexuralmosque.

What has come of this? In their wake, they have a left an unprecedented humanitarian crisis drenched in the blood of the persecuted: millions of refugees, including religious minorities, fleeing for their lives across the region; brutal mass executions, surmountable to war crimes; the widespread use of rape and sexual violence against women and children; the emergence of slave markets where minority women are bought and sold as sex slaves by violent terrorists; the destruction of ancient relics and treasured religious heritage.

Just over six months ago, the world witnessed the Yazidis, who braved the heat with nothing but the clothes on their backs, as they made their way up Mount Sinjar surrounded by ISIL. We witnessed the Syrians being forced from the Nineveh Plains, their ancestral homeland, and


These actions are abhorrent violations of the most basic principles of civilization and of human decency.

Together, we are proud of the efforts that Canada and our coalition partners are doing to help millions of innocent civilians recover from ISIL's terror. In addition, and in concert with our coalition partners, we are working to disrupt ISIL's illicit financing, counter extremist narratives, and stem the flow of foreign fighters to and from the front lines.

Through our diplomatic efforts, Canada has also heightened its engagement with regional leaders. In the last weeks, I have met with our allies in the United Arab Emirates, Jordan and Iraq, including the Kurdistan region, and we will continue to work closely with them.

In the face of this ongoing humanitarian catastrophe, more will need to beafford to stand on the sidelines and preach moral virtue. We cannot speak of supporting the mission and our soldiers in one breath while voting against them in the next. These serious and consequential times call for serious and consequential leadership.

We must act with compassion, with strength and with moral clarity. We must defend what is right.

In partnership with our coalition allies, Canada is working across multiple lines of effort to halt ISIL's campaign of terror and restore the stability that those in the region so greatly deserve.

Our resolve in this operation remains strong. Let me be clear, our commitment is ultimately to the people of Syria and Iraq for whom terror and tyranny have been inflicted, and for whom must remain the promise of a future in


of 100%, positive predictive value of 100%, and negative predictive value of 93.3% in comparison with culture as the gold standard. In general, the accuracy of rapid test was found higher than subjective clinical findings (P = 0.001).

Conclusions:
Although LAP had good performance in early diagnosis of GAS, a combination of clinical findings, including tonsillar exudates, petechiae with results of rapid antigen test or culture is necessary for clinician judgment. Throat culture is the gold standard test for detecting group A Streptococcal infection, but rapid test is a good replacement for culture.

1. Background

Acute Pharyngitis (AP) is one of the most common diseases in pediatric practice. Although the majority of APs is of a viral origin, group A β-Hemolytic Streptococcus (GABHS) is the most common bacterial etiology (1-4). Therefore, earlyto the father like that, you stupid gavone." "I oughta come and break your freakin' arm!" "Wanna go, tough guy?" "I'll snap you in half like an almond biscotti from Valero's on 51st Street, best in the city." "Fellas, this is God's house." "And the Patriots kick off in 45 minutes." " Can we move this along?" " Patriots suck." "Blasphemy!" "It burns!" "Holy water?" "Where's that acid I ordered?" "Hey, Guido, watch this." "Whoa!" "I've got to lay off the coffee." "Ha-cha-cha-cha-cha-cha!" "That's Jack's." "Exit 14 off 295." "Tae-jitsu is about power - for your body and your mind." "Don't be afraid to free the beast inside you." "Left kick, right kick, punch combo, stomp." "Beautiful." "Again." "Left kick..." " You're doing great for your first lesson."


" I'm really cutting' loose." "Like Julie Andrews in that movie where she showed her breasts." "Mary, you'll never leave us, will you?" "Lovely, but it doesn't quite answer our question." "Jets rule!" "Watch where you're going." "Horace, put the Pats game on the TV and get me a few beers." "Sorry, Peter." "Someone stole the remotes." "And the kegs." "And I'm not sure, but I think I've been shot." "Yep." "Hey, pal, watch my seat." "I gotta bleed the lizard." "Public urination is just wrong." "Except during the Million Man March when protesters burned our Porta-Pottis." "Then I used my stream of justice to put out the hate." "I don't know, fellas." "I think there's potential in this crowd." "Honey, why don't you turn around and showHe played in the U.S. Army All-American Bowl in January 2010.

College career
Flowers attracted interest from several colleges, notably Notre Dame, USC, UCLA, Arizona State University, and the University of Arizona, where he was recruited by Tim Kish. Flowers signed his letter of intent on January 9, 2010.

Flowers played sparsely during the 2010 season, recording 11 tackles in 13 games, most of which came on special teams.

Flowers moved into the starting free safety position before the 2011 season. He played in all 13 games in the 2011 season, and recorded 68 tackles (fourth most on the team), as well as 3 passes defended and an interception.

Flowers transferred to outside linebacker during 2012 training camp. Flowers transitioned well, and maintained relatively the same production that he had during his sophomore


behind schedule after a shoulder conditioning program, is getting closer to facing hitters for the first time. Price thought Iglesias could throw in batting practice by the end of the week.

• Lefty John Lamb (back) could face hitters in BP in the next 10 days. Homer Bailey (elbow) is on track to face hitters for the first time in the middle of March.

• Price expected infielder Jose Peraza to get opportunities in center field this spring, when regular Billy Hamilton is not being used.

"He would be a guy if we had an injury to Billy, he'd be a consideration as a regular outfielder," Price said.

Mark Sheldon is a reporter for MLB.com. Read his blog, Mark My Word, follow him on Twitter @m_sheldon and Facebook and listen to hisQ:

battleship game in python for a project in school

I'm a beginner at programming and I want to build a warship game in python 3.6 for my school project, I have some mistakes but I don't know how to fix it. If you try to run my code, run it until there is a mistake because sometimes there is no problem. I used to have pop out of range in placer_bateau_verticalement function and a list index out of range mistakes. Here is my code :
EDIT 4 : python code with the pseudo-code
"""//----------------library----------------\\"""
import random

"""//----------------variables----------------\\"""

gridPlayerA = [0] * 100 #IA's grid
gridPlayerB = [0] * 100 #Player's grid

gridGamePlayerA = [0] * 100 # just create a copy of the IA boards and only show the empty board

OnGame = True #


boat
                        return False
        return True

    if direc == 1: # horizontal direction
        for i in range(length):
            if ((x + 10*y + i)-9) % 10 != 0:
                if grid_playerA_init [x + 10*y + i] == 1:
                    return False
        for i in range(lenght):
            global position
            position = x + y*10
            if position >= 100:
                position = position- 10 * i
                for j in range(lenght-i):
                    position = position - 10
            #print("place_boat_vertically")


'X') #par un X

def IA ():
    tir = random.randint(0, 99)
    if check_tir(tir):
        previous_shots.append(tir)

        if tableau_joueurB_init[tir] == 1:
            replaceTir(tir)
            touché = True

            i = 1
            nextshot = tir + i
            if tableau_joueurB_init[nextshot] == 1: # + 1 (à droite)
               Sunday, November 30, 2014

NOMAD

If you have a strong and compelling desire to see what is over there on the other side of the mountain, or maybe, hike to the mountain top in the pre dawn chill, just to see the first rays of sunshine peek over the horizon, you might be a nomad.

As baby boomers retire by the thousands each day, they bring into their new lifestyle, the values instilled in them by their parents. The worlds greatest generation, the World War II Veteran’s and spouse’s. That generation, out of necessity, were world traveler’s and experienced the restlessnes brought into their lives by the upheaval of WWII.

The new Eisenhower Interstate Highway system was developing rapidly during this same time frame, and they took advantage of it in the


form of a rapidly developing Travel Trailer industry.

Because of their intense sense of duty, the world’s Greatest Generation rebuilt America while taking every opportunity to Hit the road. Many of their offspring, the Baby Boomer’s, first memory’s are of a military base and a Mobile, somewhat Spartan life style. Now as the offspring of the World’s Greatest Generation are retiring, they are often time’s hitting the open road on a full time basis.

Because they are so active and out of doors oriented, many need a trailer that they can get into those places that are just naturally good for the soul. They need a more maneuverable, agile trailer with good ground clearance.

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Deep in the heart of the Ouachita Mountains of Arkansas, Mountainborn lives theLacrimal sac cyst.
This report details the presentation, workup, and treatment of the largest lacrimal duct cyst ever reported in the ophthalmic literature. Included in this report is the first computed tomographic (CT) image of this unusual lesion. Typical and atypical clinical features of this lacrimal sac cyst are emphasized.


a stabilized *N*-glycosydic bond, that are not processed by Fpg ([@b21],[@b22]). The second class of inhibitors more extensively used for Fpg and other AP lyases contains cyclic and non cyclic AP site analogues that mimic the AP site structure in the catalytic transition state, preventing the Fpg end products synthesis ([Figure 1](#fig1){ref-type="fig"}) ([@b23]--[@b25]). We have employed both strategies to investigate the structural and/or functional determinants of the damaged nucleoside for Fpg specific recognition ([@b16],[@b20],[@b26]). In this work, we propose a comparative structural analysis of wild-type and mutant Fpg proteins bound to cyclic and non-cyclic AP site analogues containing DNA. The present four new crystal structures of Fpg/DNA complexes unfavour the recognition of the hemiacetal form of the AP site ([Figure 1](#fig1){ref-type="fig"}).

MATERIALS AND METHODS
=====================

DNA and proteins
----------------

Self-complementary 14mer single-stranded oligonucleotides([Figure 3](#fig3){ref-type="fig"}). In the vicinity of the extrahelical AP site where the enzyme contacts the DNA backbone, the structure of the 13 and 14mer bound duplexes superimpose perfectly independently of the lesion type and/or the enzyme nature. Residues at the interface between DNA and the enzyme have identical geometries with respect to previous structural data. Therefore, the crystal packing, the nucleotide sequence and the type of lesion have little impact on specific protein--DNA interactions and lesion recognition.

Fine structures of Pr- and THF-containing DNA bound by mutant and wild-type Fpg
-------------------------------------------------------------------------------

For both AP site analogues, the damaged nucleoside is flipped out off the DNA helix. At the lesion site, the B-DNA helical parameters are strongly affected by the flip-out and the local compression of the phosphate-phosphate distance ([Table 4](#tbl4){ref-type="table"}). In


is a high efficiency Fpg substrate ([@b6]). The orientation of the cyclopentane ring of cFapydG is significantly different from that of THF. Here again, THF appears to be less extrahelical than cFapydG. The replacement of the heterocyclic oxygen (present in the natural damaged nucleoside and in THF) by a methyl group would explain this observation. Indeed, the neutral group of the cyclopentane of cFapydG is less repulsed by the OE2 carboxyl group of E2 than the electronegative 4′-heterocyclic oxygen of THF. This assumption may be supported by the crystal structure of Fpg from *B.thermophilus* \[the E2Q defective mutant in DNA glycosylase activity; ([@b38])\] bound to an 8-oxodG-containing 16mer DNA duplex ([Figure 6A](#fig6){ref-type="fig"}) ([@b19]). Similarly, the non-electronegativity feature of Q2 abolishes the repulsion of the heterocyclic oxygen of theChapter 3: Religious Faith

The foregoing discussion has made it clear that without having an ideal and faith man cannot pass a healthy life nor can he render a fruitful service to humanity and human culture. A man not having an ideal and faith will either be submerged in self-seeking or will be converted into a lifeless robot groping in darkness and not knowing his duty in respect of the moral and social questions of life. He will perforce show queer reaction to such questions.

A man who adheres to a school, an ideology or faith, knows his responsibility clearly. But a man whose responsibility is not made clear by a school or a system, will pass his life in bewilderment and will sometimes be drawn to this direction and


List of animals referred to as white-lipped

The descriptive term white-lipped is part of the common name of a number of different animal species:

Brown white-lipped python or Leiopython, a nonvenomous python species, L. albertisii, found in New Guinea
Feijo white lipped frog (Hydrolaetare dantasi), a species of frog in the family Leptodactylidae
Galam white-lipped frog (Hylarana galamensis), a species of frog in the family Ranidae
Loreto white-lipped frog (Leptodactylus rhodomystax), a species of frog in the family Leptodactylidae
Mexican white-lipped frog (Leptodactylus fragilis), a species of leptodactylid frog in Texas, Mexico, Central America, Colombia and Venezuela
Northern white-lipped pitviper (Trimeresurus albolabris septentrionalis), a venomous pitviper subspecies found in Nepal and India
Wandolleck's white-lipped tree frog (Litoria albolabris), a species of frog in the family Hylidae
White-lipped bamboo viper (Trimeresurus albolabris), a venomous pitviper species found insociodemographic characteristics, laboratory results, and health care utilization, sourced from electronic health records and administrative data, were abstracted, quality assured, and assembled into a uniform database. Age was divided into the 4 following groups: 18 to 49 years, 50 to 64 years, 65 to 84 years, and 85 years and older. Race was self-reported and categorized as White, Black, and other and available for 98% of the patients included in the study. Insurance status was categorized as commercial, Medicare, Medicaid, other (eg, TRICARE, self-pay), and unknown. The Agency for Healthcare Research and Quality Elixhauser Comorbidity Index (ECI), a method of assessing comorbidities based on 29 groups of *International Statistical Classification of Diseases and Related Health Problems, Tenth Revision*(*ICD*-*10*) diagnosis codes, was calculated.^[@zoi200646r13],[@zoi200646r14]^ The index ranged from −45 to


1 estimated HRs for patient characteristics, unadjusted for other factors. Model 2 included a priori patient characteristics of interest (race, age, sex, insurance, and ECI and NDI scores). Model 3 adjusted for the covariates in model 2 and specific chronic conditions if they were significant in univariable analyses at *P* \< .05. The proportional hazards assumption for the Cox models was assessed and confirmed graphically. Sensitivity analyses were performed to investigate potential residual confounding by modeling age as a categorical variable rather than as a continuous variable. Two-sided testing was used, with *P* \< .05 considered statistically significant. Statistical analyses were performed using R version 3.6.2 (R Project for Statistical Computing).

Results {#H1-3-ZOI200646}
=======

Of 11 210 patients with confirmed COVID-19, 5583 (49.8%) were men. The median (interquartile range \[IQR\]) age was 61 (46 to 74)2020, and not included in time-to-event analyses. [Table 3](#zoi200646t3){ref-type="table"} shows the Cox proportional hazards mixed effects models for patient characteristics associated with all-cause, in-hospital mortality. In the final adjusted model (model 3), persons older than 85 years, aged 65 to 84 years, and aged 50 to 64 years had 3.96 (95% CI, 2.82-5.55), 2.38 (95% CI, 1.73-3.26), and 1.36 (95% CI, 1.11-1.67), respectively, times the risk of death compared with those aged 18 to 49 years. Male patients had 1.23 (95% CI 1.11-1.36) times the risk of death compared with female patients. Patients with Medicare insurance (HR, 1.47; 95% CI, 1.08-2.00) and individuals whose insurance coverage was unknown (HR, 2.17; 95% CI, 1.32-3.57) had higher risk of mortality than those with commercial insurance. Patients with chronic kidney disease


to its free to play nature and after iOS Fortnite is coming to Android this June.

Epic Games has officially confirmed the game will be available before August end. Voice chat, mute chat, custom HUD, a stats tracking feature and ability to run game with low textures for those midrange devices will make sure Fortnite is mobile ready.

Also, changes will be made to rerun games quickly so as to have lower loading times, reduction in install size, improvement in stability and smooth game playback.

As the game is free to play expect it to grow drastically once it launches on Android this summer.

]]>http://phonehorn.com/2018/05/20/fortnite-coming-to-android-very-soon/feed/04376OnePlus 6 Launched in India Price Starts at ₹34999http://phonehorn.com/2018/05/19/oneplus-6-launched-in-india-price-starts-at-%e2%82%b934999/
http://phonehorn.com/2018/05/19/oneplus-6-launched-in-india-price-starts-at-%e2%82%b934999/#respondSat, 19 May 2018 05:15:27 +0000http://phonehorn.com/?p=4364OnePlus has been growing since its launch and one of the keys to their successHorn Trio (Holbrooke)

Joseph Holbrooke's Horn Trio in D minor, Op. 28 , is a chamber composition for a trio consisting of horn, violin and piano. Conceived as a companion piece to Brahms's Horn Trio Op. 40 the work was composed no earlier than 1904 and revised by the composer between 1906 and 1912.

Structure

The composition is structured in three movements:
 Larghetto sostenuto – Allegro con brio
 Adagio non troppo
 Rondo: Molto vivace

A typical performance takes around 27 to 30 minutes.

See also
 Horn trio
 Trio for horn, violin, and piano (Banks)
 Trio for horn, violin, and piano (Berkeley)
 Trio for Violin, Horn and Piano (Ligeti)

References
Notes

Sources

External links

 - Reviews of the Naxos recording, with additional notes by the author of the liner notes to the Naxos Album.

Category:Compositions by Joseph Holbrooke
Holbrooke
Holbrooke
Category:1904 compositions
Holbrooke