to some degree when attempting to differentiate AD from some other types of cognitive disorders, when combined with Aβ~42~ the above biomarkers achieve sensitivities and specificities approaching or exceeding 90% for the discrimination of AD from normal aging.

CSF *τ*~T~ levels in VCI provide conflicting results ranging from normal \[[@ref171]\] to increased \[[@ref174]\], or to intermediate between controls and AD cases but much lower when compared with AD \[[@ref179]\]. Some patients with VCI may present with high or even very high *τ*~T~ levels \[[@ref173]\]. When patients with "pure" VCI and MXD or AD pathology with subcortical white matter lesions are clinically separated, the results were again conflicting with *τ*~T~ in VCI reported as comparable to the controls \[[@ref173]\], increased \[[@ref178]\] or intermediate but much lower as compared to thoseMotor point map of upper body muscles.
The purpose of the present study was to systematically investigate the upper body motor point (MP) positions of selected muscles and to create an atlas of the identified MPs. MPs were searched bilaterally in 15 male and 15 female subjects by scanning the skin with a special pen electrode at low stimulation frequency (3 Hz) and current amplitude (<10 mA). The following muscles were investigated: biceps brachii, triceps brachii, deltoideus, trapezius, latissimus dorsi, erector spinae (lumbar part), pectoralis minor and major, and rectus abdominis. A total of 1,563 MPs were identified. The MPs could be clustered into 31 distinct positions on each side of the body. However, the number of MPs per muscle varied between subjects: 2 MPs were found for the


due to improper washing of ingredients.

More than 30 of the children remained hospitalized as of Wednesday, several of them in serious condition.

The lunches were part of a longstanding government-funded program to provide meals to 120 million poor schoolchildren across the country. Now one of the world’s largest school nutrition efforts, the program began in the 1980s in western India and was implemented in the rest of the country in 1995. Its primary aim is to combat widespread malnutrition that afflicts nearly half of India’s children.

State Education Minister P.K. Sahi told local media that grain ingredients used in the lunches may not have been washed beforehand, which might have led to the poisonings. However, according to some parents interviewed, only children who ate potatoes and soybeans became ill. Themeal was cooked in the school kitchen. Authorities lodged a case of criminal negligence against the school’s principal.

The poisonings prompted violent protests in Gandamal, the village where the school is located. Angry demonstrators forced the shutdown of local shops and businesses and set several vehicles ablaze.

ALSO:

John Kerry pushes for restart of Israeli-Palestinian talks

Outspoken Assad supporter assassinated, dies in hail of bullets

Arrest of Zetas cartel boss may prove Mexico’s commitment to U.S.


is best described as an equilibrium between the two static minimum structures. Calculations of the vibrational frequencies show that the earlier predicted C2 and C2v symmetric isomers are in fact saddle points, with one imaginary normal mode frequency that is related to the flipping motion of the confined carbon dimer. Reoptimisation revealed two new minimum energy structures where the C2 unit is tilted with respect to its orientation in the earlier suggested higher-symmetry structures. The nature of the bonding in the static structures of the two isomers of Sc3C2@C80 has been investigated using the electron localisation function and natural population analysis. Some increased electron pair localisation is detected on the six-membered rings closest to the Sc atoms. 13C nuclear magnetic resonance (NMR) chemical shifts have been calculated forsprouted a flower. I interpreted it as a metaphor for the resiliency and persistence of life.

  * Search for a metaphor while walking and gazing.
  * What ties you to this metaphor at this particular moment?

### Looking Again at What Is Familiar

_People alter so much that there is something new to be observed in them forever_.

Jane Austen

Who hasn't had the experience of not noticing some vital change in a loved one we see daily? Perhaps it is only new clothes or a new hairstyle or something more, like a change in mood caused by depression or a juicy secret. Just for a week, commit to taking notice of what is familiar and then expressing it to a loved one or friend.

### EXERCISE

Describe a time when you


MacInnis says his sister also suffers from bed sores and, if the law permitted it, she would be a candidate for euthanasia.

“It’s an awful thing to say, but my sister would be better off gone from this world.”

He believes Nova Scotia should adopt a right-to-die bill like the one recently passed in Quebec.

“I think they should have euthanasia. If your mind is gone, or you’re terminally ill, I think it should be your choice,” says MacInnis.

However, the bill passed in Quebec stipulates that patients themselves would have to repeatedly ask a doctor to end their lives on the basis of unbearable physical or psychological suffering. They would have to be deemed mentally sound at the time of the requests.

Francoise Baylis, an ethics professor at Dalhousie University, says Quebecnot for the family members of anyone who wishes to have assistance in bringing about the death of a family member,” says Baylis.

Nova Scotia Health Minister Leo Glavine says euthanasia is not on the table at the moment.

“I want to work on having the highest quality at end of life through palliative care,” says Glavine.

MacInnis says it is very difficult for him to see his sister in such a condition, and he just wants to take away her pain.


= null;
        try {
            try {
                is = new FileInputStream(src);
                byte[] buf = new byte[BUFFER_SIZE];
                int len;
                while ((len = is.read(buf)) > 0) {
                    os.write(buf, 0, len);
    Arras Flying Services Memorial

The Arras Flying Services Memorial Commonwealth War Graves Commission war memorial in the Faubourg d'Amiens Cemetery, Arras, France. The memorial commemorates nearly 1,000 airmen from forces of the Commonwealth who were killed on the Western Front during World War I and who have no known grave. The memorial was designed by Edwin Lutyens, sculpted by William Reid Dick and unveiled by Hugh Trenchard, 1st Viscount Trenchard, Marshal of the Royal Air Force on 31 July 1932.

Background
In the spring of 1916, French troops transferred the city of Arras in Pas-de-Calais, France, to the British armed forces. Construction of the British portion of Faubourg d'Amiens Cemetery in the western portion of Arras, near the Citadel designed by Vauban, began in March 1916, behind the existing French graveyard.


format!("Can't dequip {:?} because it's not an Item.", self),
            RED,
        );
        return;
    };
    if let Some(ref mut equipment) = self.equipment {
        if equipment.equipped {
            equipment.equipped = false;
            messages.add(
                format!("Dequipped {} from {}.", self.name, equipment.slot),
                LIGHT_YELLOW,
   we could show which items are equipped in the
inventory screen. Replace the `inventory.iter().map(...)` line in
`inventory_menu` with:

[source]
----
tag::inventory_menu_fn_show_equipment[]
inventory
    .iter()
    .map(|item| {
        // show additional information, in case it's equipped
        match item.equipment {
            Some(equipment) if equipment.equipped => {
                format!("{} (on {})", item.name, equipment.slot)
            }
            _ => item.name.clone(),
        }
    })
    .collect()
end::inventory_menu_fn_show_equipment[]
----

We


 fighter.hp += 20;
    }
    1 => {
        fighter.base_power += 1;  // <5>
    }
    2 => {
        fighter.base_defense += 1;  // <6>
    }
    _ => unreachable!(),
}
end::level_up_fn_fighter[]
----
<1> `max_hp` -> `base_max_hp`
<2> `power` -> `base_power`
<3> `defense` -> `base_defense`
<4> `max_hp` -> `base_max_hp`
<5> `power` -> `base_power`
<6> `defense` -> `base_defense`

And finally, the orc and troll monsters need to use `base_max_hp` now:

[source]
----
// create an orc
tag::generate_orc[]
let mut orc = Object::new(x, y, 'o', "orc", DESATURATED_GREEN, true);
orc.fighter = Some(Fighter {
    base_max_hp: 20,
    hp: 20,
    base_defense: 0,
    base_power: 4,
    xp: item: Item::Sword, // <1>
    },
    Weighted {
        weight: from_dungeon_level(
            &[Transition {
                level: 8,
                value: 15,
            }],
            level,
        ),
        item: Item::Shield, // <2>
    },
end::item_tables_equipment[]
];
----
<1> This replaces `Item::Equipment`
<2> This is new

and further down in the `match`


[Importance of prolactinemia and IgA-transferrin ratio in chronic alcoholism and alcoholic hepatopathies].
Levels of prolactinaemia, IgA and transferrin and the ratio between the two latter were measured in 20 male chronic alcoholics and a second group of controls in order to verify the diagnostic importance of such measurements. In partial conflict with reports in the literature, it is concluded that prolactinaemia measurement is not particularly important. The evaluation of the IgA-transferrin ratio, on the other hand, is judged to be useful for the diagnosis of alcohol-induced hepatopathologies.          <button ui-turn-on='myDropdown' class='btn' ng-click="getDataFromServer()"
                    style="width:160px;background-color:white; color:#c62222">

                       Select City


KS1 Sats parent's workshop

On Tuesday 25th April Miss Papworth held a parent explaining Year 2 SATs.

The testing process as well as the ongoing teaching assessments were explained by Miss Papworth. She also explained some exemplar questions that were typical. Please see the presentation attached to this page for you to refer to. Note that if you feel you need any further support witht this topic then you (parents) are very welcome to meet with your teacher, who will be more than happyto help you.Increased intracellular concentrations of cyclic AMP (cAMP) inhibit all platelet responses including shape change, adhesion, aggregation, and secretion. The levels of cAMP are controlled at the level of receptors by stimulation or inhibition of adenylate cyclase or by its hydrolysis by cAMP phosphodiesterases (PDEs). The predominant PDE in platelets is a low Km cGMP-inhibited PDE (cGI PDE). Studies of the cGI PDE are ongoing and involve cloning and expression of the enzyme in order to study the active site region by molecular biology techniques. Previous studies from several labs indicate that this enzyme is stimulated by phosphorylation at sites distinct from the active site region. The primary objective of this proposal is to delineate the regulation of the cGI PDE in platelets and HEL cells by phosphorylation, determine


     ignoreFiles: options.ignoreFiles || ['.gitignore'],
      filter: function (entry) { // {path, basename, dirname, type} (type is "Directory" or "File")
        var basename = entry.basename
        // some files are *never* allowed under any circumstances
        // these files should always be either temporary files or
        // version control related files
        if (basename === '.git' || basename === '.lock-wscript' || basename.match(/^\.wafpickle-[0-9]+$/) ||
            basename === 'CVS' || basename === '.svn' || basename === '.hg' || basename.match(/^\..*\.swp$/) ||
 return
    }

    return cb(new Error('Unrecognised package type'));
  })
}

function type(stream, callback) {
  stream.on('error', handle)
  stream.on('data', parse)
  function handle(err) {
    stream.removeListener('data', parse)
    stream.removeListener('error', handle)
  }
  function parse(chunk) {
    // detect what it is.
    // Then, depending on that, we'll figure out whether it's
    // a single-file module, gzipped tarball, or naked tarball.

    // gzipped files all start with 1f8b08
    if (chunk[0] === 0x1F && chunk[1] === 0x8B && chunk[2] === 0x08) {
      callback(null, 'gzip')
    } else if (chunk.toString().match(/^package\/\u0000/)) {
      // note, this will only


Cope, L. M., Hardee, J. E., Soules, M. E., Burmeister, M., Zucker, R. A. and Heitzeg, M. M. (2016), Reduced brain activation during inhibitory control in children with *COMT* Val/Val genotype. Brain and Behavior, 6: 1--11. e00577, doi: [10.1002/brb3.577](10.1002/brb3.577)

1. Introduction {#brb3577-sec-0005}
===============

Substance use initiation by age 13 is associated with greater risk of developing a substance use disorder (SUD) (Grant & Dawson, [1997](#brb3577-bib-0033){ref-type="ref"}) and can have a negative impact on academic achievement, family and peer relationships, and psychosocial maturation (Schulenberg, Bryant, & O\'Malley, [2004](#brb3577-bib-0055){ref-type="ref"}). Understanding the biological risk structure that drives early substance use onset may aid in the development of more effective prevention strategies to reduce the incidence and impact of SUD.

One of the most robust risk factors for SUD, identifiable prior to the initiation of substance use,adults are also assessed every year from age 11--26. Families were excluded during MLS recruitment if the target child displayed evidence of fetal alcohol effects or the mother reported drinking during pregnancy. Exclusionary fetal alcohol characteristics included prenatal or postnatal growth retardation or both, central nervous system involvement, and characteristic facial dysmorphology (Loukas, Fitzgerald, Zucker, & von Eye, [2001](#brb3577-bib-0042){ref-type="ref"}; Sokol & Clarren, [1989](#brb3577-bib-0060){ref-type="ref"}). Full details on assessment and data collection in the MLS can be found elsewhere (Zucker et al., [2000](#brb3577-bib-0076){ref-type="ref"}).

For this study, participants were excluded if they had: neurological, acute, or chronic medical illness; current, active Axis I disorder (not including past mood disorder or current or past anxiety disorder, conduct disorder, or ADHD); current or recent (within 6 months) treatment with centrally active medications; MRI contraindications such as


parent met these criteria the subject was considered *family history negative* (FH−). In addition, family history of AUD during the child\'s lifetime was also specified. For diagnoses (e.g., ADHD, major depressive disorder, conduct disorder), the computerized Diagnostic Interview Schedule for Children (C‐DISC; Shaffer, Fisher, Lucas, Dulcan, & Schwab‐Stone, [2000](#brb3577-bib-0056){ref-type="ref"}) was given and diagnoses were tallied based on DSM‐IV criteria.

Substance use was assessed every three years between ages 6 and 10 with a Health and Daily Living Questionnaire as part of the regular MLS assessment schedule. Questions covered use of marijuana, alcohol (more than a sip), cigarettes, and other drugs. If relevant, the age at which use occurred and the quantity/frequency of use was recorded. Subsequent annual assessments (i.e., starting at age 11) involved the Drinking and Drug Historyalso trend‐level effects of sex on *d*\', *F*(1, 59) = 3.65, *p *=* *.061 (females \> males) and hit reaction time, *F*(1, 59) = 3.12, *p *=* *.083 (females \> males). There were no other significant effects.

3.3. Imaging results {#brb3577-sec-0018}
--------------------

### 3.3.1. Main effects of successful inhibition {#brb3577-sec-0019}

#### CRs versus FAs {#brb3577-sec-0020}

A one‐sample *t*‐test on the contrast of correct rejections (CRs) versus false alarms (FAs) showed significant activation in the right and left putamen (Fig. [1](#brb3577-fig-0001){ref-type="fig"}, Table [3](#brb3577-tbl-0003){ref-type="table-wrap"}).

![Correct Rejections versus False Alarms, Main Effect of Genotype. Whole‐brain main effects analysis of correct rejections versus false alarms showed activation in left and right putamen. These regions are significant at a family‐wise (FWE) corrected threshold of *p *\<* *.05, with a 25 voxel extent. The color bar represents *t*‐values and the *y*‐coordinate is in Montreal Neurological Institute (MNI) space. Bar graphs depict significant main effects of genotype


results are also relevant for understanding how specific genes influence brain functioning related to SUD and other psychopathologies. It will be important for follow‐up studies to continue elucidating the pathway from dopamine‐related genes such as *COMT*, to inhibition‐related cognitive functioning, and finally to disinhibitory psychopathological outcomes, including substance abuse.

Conflicts of Interest {#brb3577-sec-0027}
=====================

The authors report no conflicts of interest.

Supporting information
======================

######

######

Click here for additional data file.

######

######

Click here for additional data file.

This work was supported by R01 DA027261 to MMH and RAZ; R01 AA12217 to RAZ and MMH; R01 AA07065 to RAZ and MMH; K01 DA020088 to MMH; UL1TR000433 to LMC; and by T32 DA007268, T32 DA007267, and T32 AA007477.

A subset of these participants (*n *=* *50) is the same as those from Hardee et al., [2014](#brb3577-bib-0034){ref-type="ref"}.

The number of runssupposed benefits of ST3 ever materialize. ST3 involves massive increases in car tab taxes, skyrocketing sales taxes and property taxes diverted from schools – struggling taxpayers can only afford so much. Seniors hit hardest by the tax hikes will be dead before ST3 is completed!

Nothing they’re promising needs to match what’s delivered. Several court rulings have established that costs, timelines, and projects promised during the campaign are not binding. The only thing certain about ST3 are its massive permanent tax increases.

Why should everyone outside Seattle be forced to pay for their multi-billion dollar boondoggle that only a tiny percentage of people will ever ride 25 years from now? It’s pure insanity.

Besides, experts point out that ST3 will be obsolete before it’s built.

The Times reported that if I wasn’t


had the most complex initial structure in comparison to more standard groups. In effect, at the beginning of the study, it included 21 family physicians (equivalent to 10 full-time) from both a *medical clinic* and a *university family medicine unit* (FMU) in a community hospital setting, 2 nurses considered as staff of the neighbourhood *community health centre*, and 2 administrative staff members. The group was also accredited as a *Network Clinic* in January, 2008. By the fall of that year, the organization had significantly increased its medical staff to 41 physicians.

The main method adopted for generating data was face-to-face, one-on-one interviews \[[@B30]\] with managers, physicians, nurses and administrative staff, conducted by both authors from the fall of 2002 to the summer of 2008 at different points in time:entity.

From the onset of the project at the study site, the complexity of the organization was obvious to everyone involved. To reiterate, the case study targeted a FMG of great complexity, integrating two medical sites with different traditions of practice, and whose members overlapped, albeit not completely. Not only was this FMG among the first to implement a multidisciplinary primary care practice, it was also facing the integration of geographically separate sites with different styles of practice (see excerpt 1 in *Uneasy departure and uncertainty about destination*). Recruiting physicians at the FMU and at the clinic was not an easy task for the group leader. Physicians remained wary of the thick contracts that had to be signed with government agencies, and wondered if all the advantages that they


FMG administrative meetings, and it was yet another source of conflict with the support staff. They were the ones faced with refusing patients based on their FMG status, and they did not feel comfortable doing so:

I don't agree about the walk-in clinics. Prioritize the patients for some appointments, for follow-ups. Because you are not FMG, you won't get to see the nurse. That I can understand; it is hard to live with, but I can still tell them. But don't go refusing patients at the walk-in clinic because they are not FMG. In any ways, they will not have my collaboration for that. (Support staff)

As the excerpt below illustrates, some physicians even decided to withdraw from the FMG when they realized the bureaucratic weight that it represented and.. module:: george.modeling

.. _modeling-protocol:

Modeling Protocol
=================

This module provides some infrastructure that makes it easy to implement
abstract "models" to be used within the george framework. Many of the
methods are probably more generally applicable but the implementation
constraints can be simplified since we're just concerned about supporting the
needs of george.

The basic premise is that a :class:`Model` is an object that has an ordered set
of named parameters. These parameters are assumed to be continuous but they can
have bounds. There is also the concept of an "active set" of parameters that
are being varied in a fit procedure. The other parameters are "frozen" to a
particular value. Frozen parameters can be "thawed" to be returned to the
active set.

There isn't a formal requirement for the "value" interface that a
:class:`Model` subclass should implement but in some cases, a


from django.conf import settings
import psycopg2

class PostgreSQLFailoverRouter(object):
    """
    A custom database router that loops through the databases defined in django.conf.settings.DATABASES and returns the
    first one that is not read only. If it finds none that are writable it calls exit() in order to convince docker
    to restart the container.
    """
    DSNS = dict()
    CACHED_MASTER = None

    def __init__(self):
        """
        Builds the list of DSNs from django's config and determines the writeable host.
        """
        self._get_dsns()
    # 'on' for slaves, 'off' for masters
            row = cur.fetchone()
            if row[0] == u'off':
                cur.close()
                conn.close()
                return name
            cur.close()
            conn.close()
        return None

    def _get_dsns(self):


:param hints: hints to help choosing a database (disused)
        :return:
        """
        if not self.CACHED_MASTER:
            exit()
        return self.CACHED_MASTER

    def db_for_write(self, model, **hints):
        """
        Returns a django database connection name for writing or kills itself
        :param model: django model (disused)
        :param hints: hints to help choosing a database (disused)
        :return:
   environments, the results are not intercomparable due to differing analytical procedures, emission characteristics, or operational definitions.

The most common approach for measuring diesel exhaust exposure has been the determination of elemental carbon (EC) or total carbon (TC) in the particulate fraction. Use of these surrogate exposure metrics is driven largely by the fact that most occupational exposure limits have been expressed in terms of the carbon content in diesel particulates. The American Conference of Governmental Industrial Hygienists (ACGIH) first added diesel exhaust to its list of intended changes in 1995 and recommended an 8-hour threshold limit value (TLV) of 0.15 mg/m^3^ as total diesel particulate matter (DPM). The ACGIH then lowered the value to 0.05 mg/m^3^ in 2001. This value was replaced with an equivalent TLV of 0.02 mg/m^3^


diesel exhaust from a variety of nonvehicle-related sources. Although issues of cost, reliability, and specificity may exist, exposure biomarkers have clearly become a highly desirable method for reducing the uncertainties and exposure misclassifications associated with more conventional approaches to diesel exposure assessment ([@R30]).

C.. Aging Considerations {#s5}
------------------------

Nucleation, condensation, and adsorption are all important processes that take place as freshly emitted diesel exhaust cools and ages. The exhaust aging process results in the formation of new liquid aerosols and the deposition of volatile and semivolatile organics onto particle surfaces. The first step in the aging process, nucleation, occurs when inorganic substances are oxidized and transformed to very small microparticulates that serve as condensation sites for further particle growth ([@R237]). The condensation nuclei found in DPM are composed of sulfate, nitrate,is observed in the ambient environment, reliance on these data as a basis for identifying potential biomarkers needs to be tempered by the fact that diesel exhaust undergoes two separate dilution stages under real-world conditions. The (1) tailpipe to road and (2) road to ambient air dilution stages results in an overall dilution of 1:10,000 within a 10 min timeframe ([@R256]). In contrast, the dilution tunnels used with chassis dynamometers only achieve an average dilution of 1:20--1:200. This testing artifact has been shown to affect the particle partitioning of semivolatile organics and artificially increase the amount of PM~2.5~ and OC that is collected, but the extent depends to a large degree on the engine load and the amount of organics present in the exhaust ([@R144]). Unlike the partitioning


diesel fuels have recently been introduced in some areas of the world, and their emissions profile compare favorably with more traditional diesel fuels with lower aldehyde and aromatic levels in the exhaust ([@R24]).

Use of biofuels has attracted considerable attention by many since they hold promise as both a renewable energy resource and an alternative approach to emissions control. Although modern diesel engines are capable of using hydrotreated vegetable oils as a fuel, the most commonly encountered biodiesels are produced by the transesterification of fatty acids derived from any of several animal or vegetable oil sources such as tallow, sunflower seeds, or rapeseeds ([@R167]). The resulting biodiesel fuel contains fatty acid methyl esters (FAME) that can vary in chain length from C~1~ to C~3~. Biodiesel fuels are named accordingurine specimens were generally highest for naphthalene, phenanthrene, and fluoranthene, whereas those PAHs possessing 5-rings were below the detection limit in most cases. The urinary recovery of these three parent substances was far less than the amounts for corresponding hydroxylated metabolites, which were nearly 20-fold higher.

In a separate study, unmetabolized benzo(*a*)pyrene was not detected in the urine of coke-oven workers exposed to a variety of PAHs, but the concentrations of naphthalene, phenanthrene, and pyrene were strongly correlated with the exposures expected in three different job categories ([@R244]). Although these results are intriguing, they are not likely to apply to workers exposed to diesel exhaust since the PAH concentrations are far lower than those observed for coke-oven workers. Likewise, PAHs such as these are commonly detected in a host


is linked to an occupational exposure limit for pyrene ([@R111]). Alternatively, the concentration in urine can be related back to the total PAH exposure as a benzo(*a*)pyrene equivalent concentration using the benzo(*a*)pyrene to pyrene ratio in the workroom air as an adjustment factor ([@R29]).

The value of using 1-hydroxypyrene as a biomarker in workplaces where diesel exhaust is the primary source of PAH exposure is, however, not entirely clear. Several studies failed to show a good correlation between exposure concentration and urinary excretion once all confounding influences were factored into the analysis. A comparison of the urinary 1-hydroxypyrene levels in shale-oil miners employed above ground and below ground showed only a small difference, despite known differences in the level of diesel exhaust ([@R207]). Cigarette smoking, grilled food consumption, andexcretion was also observed in workers from an engine repair shop relative to a matched control group, and the results did not reveal any apparent impact from cigarette smoking ([@R113]).

An examination of the results for 2000 subjects participating in the US National Health and Nutrition Examination Survey revealed that 99% of the participants excreted measurable amounts of 1-hydroxypyrene levels in their urine with the average median value equaling 0.04 *µ*mol/mol of creatinine. Cigarette smokers were found to have 3-fold higher levels than nonsmokers ([@R99]). In general, workplace studies have not demonstrated a universal correlation between urinary 1-hydroxypyrene levels and airborne levels of pyrene or total PAHs. For this reason, and because of the influence of age, gender, diet, alcohol, medicine intake, and activity patterns, a standard biological exposure


in its infancy, there is concern that high background concentrations resulting from atmospheric nitration reactions will limit the value of this approach ([@R101]).

Of the three biomarker categories listed above, the nitrated polycyclics hold the greatest promise for yielding an exposure marker that meets the sensitivity requirements of diesel exhaust. However, because many of these substances can be formed secondarily in the atmosphere, the vast majority are liable to have inadequate specificity in many exposure situations. The exception to this finding is 1-nitropyrene, which is not formed through atmospheric nitration reactions and is reasonably stable to further oxidative change following air dispersion. This substance also possesses other favorable characteristics including its emission following the use of both diesel and biodiesel blends and its relatively good resilience to exhaust streamin heavy-duty vehicles ([@R92]). Although these devices have not yet come into widespread use within the US, retrofit rules are beginning to take effect in states such as California ([@R158]). In contrast, DPFs are common in Europe where the requirements of EURO IV have mandated large reductions in the emission of PM ([@R189]). One consequence of using these new pollution control devices is the emission of nanoparticulates with aerodynamic diameters of 50 nm or less ([@R96]). The carbon content of these nanoparticulates is, however, very low, and their composition is dominated by the presence of inorganic sulfates ([@R93]).

In diesel vehicles operating without advanced aftertreatment devices, over 90% of the particle numbers in the exhaust are emitted as carbon-based nanoparticulates ([@R121]). The soot nanoparticulates from diesel engines possess some


had many direct and indirect sources including their release during wood burning and meat cooking ([@R205]). Because of their polarity, these substances possess some peculiar characteristics that distinguish them from other more hydrophobic substances. First, polycarboxylic acids, keto acids, and dicarbonyls are all associated with the water-soluble organic fraction (WSOC) that can be extracted from urban aerosols. Second, WSOC materials are thought to be intimately associated with the formation of SOAs in the troposphere through their condensation on atmospheric nuclei ([@R81]). Finally, once formed, these substances are relatively stable to further atmospheric transformation processes that can alter their oxidation state.

Research has shown that low molecular weight aliphatic dicarboxylic acids such as butanedioic, hexanedioic, and propanedioic acid are formed through the photooxidation of airborne precursors, whereas high molecular weightinformation helping to elucidate its chemical and physical nature. Perhaps the greatest achievement during this period has been the creation of a Diesel Speciation Database (DSD) that contains a compilation of all emissions test results for a variety of engine categories, model years, and fuel types ([@R97]). This truly ambitious project has resulted in the first-ever collection of findings from nearly 60,000 different test cycles. The information has been segregated in such a fashion that the average emission factors for 928 individual chemical substances can be extracted and tracked as a function of vehicle age ([@R163]). Although created primarily as an aid to the development of emission inventories and mass balance models, the database also provides an opportunity to systematically search for potential biomarkers that meet many of


prior to analysis by gas chromatography/tandem mass spectrometry. Of particular interest is the prevalence of the three dinitropyrenes in the diesel exhaust samples. Although there is a limited amount of information available on these substances, some urban air measurements have been performed. Two of the three dinitropyrenes, 1,3-dinitropyrene and 1,8-dinitropyrene, were detected in winter, but not summer, air samples from the city of Strasbourg, Germany, at concentrations ranging as high as 21 pg/m^3^ ([@R55]). As noted in [Table 7](#T7){ref-type="table"}, studies have shown that these three compounds are not found in appreciable quantities in gasoline exhaust, tire debris, or asphalt paste ([@R183]). The concentration of 1,3-dinitropyrene and 1,8-dinitropyrene in aerosol samples has been shown to decrease in expected fashion with urban particulates \> suburban particulates \> rural particulates ([@R4]).[@R107]). The issue, however, is not clear-cut since major questions persist regarding potency and the relative impact of other nonspecific background sources on any aggregate measure of risk. Without a clearly defined measure of diesel exhaust exposure, the strength of any association between exposure and health risk remains unknown or highly uncertain. Despite the uncertainties, however, use trends and potential health effects have necessitated an ever-changing array of pollution control measures for limiting exhaust emissions.

Past, present, and future emission control regulations continue to have a huge impact on the chemical and physical characteristics of diesel exhaust and have forced the design of new technologies for limiting the emission of potentially harmful gases, vapors, and particulates ([@R34]; [@R93]). In fact, current regulations in effect within the United States and


of China'
author:
- 'Y. T. Chen'
- 'C. C. Chao'
- 'S. Y. Huang'
- 'C. S. Tang'
- 'S. J. Cheng'
title: 'Singlet-triplet transitions in highly correlated nanowire quantum dots'
---

Nanowire quantum dot ,Exchange ,Correlation ,Singlet-triplet transition

\[\]

Introduction
============

For years, few electron charged quantum dots have attracted extensive attention due to the controllable electronic and spin properties  [@Reimann02]. However, only few attempts have so far been made for studies of finite 1D nanowire quantum dots (NWQDs). More recently, it was shown that the NWQDs formed in the heterostructures in nanowires can be fabricated as single electron transistors and successively charged with controlled number of electrons [@Bjork04]. The successful experimental works motivate us to explore the possible geometric effects of NWQDs characterized by their aspect ratios, $a$, on the electronic and spin properties of two-electron charged NWQDs.

In thiswhere $n,m,q=0,1,2\cdots$ denote oscillator quantum numbers, $s_z=+\frac{1}{2}$ ($s_z=-\frac{1}{2}$) the projection of electron spin $\uparrow$ ($\downarrow$) $E_{\rm Z}= g^\ast \mu_{B}B s_z$ the spin Zeeman energy, and $\omega_{\pm}=\omega_h \pm \omega_c/2$ is defined in terms of the hybridized frequency $\omega_h\equiv
(\omega_0^2+\omega_c^2/4)^{1/2}$ and the cyclotron frequency $\omega_c={eB}/{m^\ast}$. .

The eigenstate $|n,m,q\rangle$ possesses the orbital angular momentum $l_z=\hbar (n-m)$ and the parity $P=1$ ($P=-1$) with respect to $z-$axis for the even (odd) $q$ number. The wave function of the lowest orbital is given by $\psi_{000}(\vec{r})= \exp \left[ -\left(\left(x^2+y^2\right)/{l_h^2} + {z^2}/{l_z^2} \right)/4 \right]
/\left(2 \pi^{3/4} {l_h} \sqrt{l_z}\right)$ with the characteristic lengths of the wave function extents $l_h=\sqrt{{\hbar}/{2 m^\ast \omega_h}}$ and $l_z=\sqrt{{\hbar}/{2
m^\ast \omega_z}}$, from which one can generate the wave functions of any other excited states by successively applying raising operators [@Hawrylak93]. For most synthesized NWQDs, the diameter


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a “remarkable employee” who

amassed numerous awards to reflect his “outstanding” employment record throughout

his decades-long tenure as an employee with Defendant United States Department of

State (“State”). (Am. Compl., ECF No. 22, ¶ 24.) Still, after Horsey engaged in a

work-related altercation with a co-worker in 2011, State required Horsey to undergo a

mental evaluation, and when Horsey refused to be evaluated without a union

representative present, Horsey’s security clearance was suspended and he was placed on

administrative leave. (See id. ¶ 34.) State later suspended Horsey indefinitely without

pay and revoked his security clearance altogether. (See id. ¶¶ 37, 39.) In the instant

legal action, Horsey maintains that State undertook those employment actions because

he is African American (see id. ¶¶ 8, 22); indeed, his two-count complaint claims that

State discriminated against him on the basis ofhis race and subjected him to a hostile

work environment, both in violation of Title VII of the Civil Rights Act of 1964, 42
U.S.C. § 2000e, et seq. (see id. ¶¶ 48–54; 55–59).

        Before this Court at present is the State Department’s motion to dismiss Horsey’s

amended complaint for failure to state a claim upon which relief can be granted under

Federal Rule of Civil Procedure 12(b)(6). (See Defs.’ Mot. to Dismiss Am. Compl.

(“Defs.’ Mot.”), ECF No. 28.) For the reasons explained below, this Court agrees with

State that Horsey’s amended complaint misses the mark, primarily because the pleading

does not allege that Horsey suffered an adverse employment action because of his race,

nor does it describe discriminatory conduct that is severe or pervasive enough to make

his


unit.” (Id. ¶ 26.) According to the amended complaint, on May 6, 2011,

                                            3
Horsey received a letter from the Office of Personnel Security and Suitability Bureau of

Diplomatic Security, which stated that Horsey was being referred to the Office of

Medical Services “for review and evaluation” (id. ¶ 27), and that “[p]ursuant to

retention of [Horsey’s] continued security clearance eligibility,” Horsey would have to

schedule such an evaluation (id. ¶ 29). The letter also included an advisory “that non-

compliance with this directive could have negative consequences with regard to

[Horsey’s]Suspension

Without Pay” letter (id. ¶ 35), and was “suspended indefinitely on Mar[ch] 16, 2012”

(id. ¶ 37). Between receiving the letter and his indefinite suspension going into effect,

Horsey had “attended an appeal hearing on January 17, 2012” (id. ¶ 36), and his

indefinite suspension without pay was later rescinded (see id. ¶ 38). However, on June

6, 2012, Horsey was notified “that his Top Secret [Security] Clearance ha[d] been

revoked[.]” (Id. ¶ 39.)

                                             4
       B.     Procedural History


the revocation of Horsey’s security clearance, which is precisely the type of judgment that
Egan instructs must be left to the Executive Branch.” Horsey, 170 F. Supp. 3d at 268 (citing Egan, 484
U.S. at 527–30).

                                                   6
employee brings a Title VII claim that is based on an allegedly false and discriminatory

report or referral to the securities clearance authorities.” Id. at 269 (emphasis in

original) (citing Rattigan v. Holder (Rattigan II), 689 F.3d 764, 771 (D.C. Cir. 2012)). 3

The Court based its(D.C. Cir. 2015); see also Njang v.
Whitestone Grp., Inc., 187 F. Supp. 3d 172, 181 (D.D.C. 2016) (noting that Egan poses no bar to a
plaintiff who challenges an alleged discriminatory referral to security clearance authorities on Rattigan
grounds). With respect to Horsey’s initial complaint, this Court explained that “[a] plaintiff seeking to
advance a Rattigan-based Title VII claim related to an agency’s revocation of his security clearance
must show that: (1) the agency employee had a discriminatory or retaliatory motive to report the
plaintiff or to refer false information about him, and (2) the reporting employee knew that the report or
referral of information was false.” Horsey, 170 F. Supp. 3d at 269 (citing Rattigan II, 689 F.3d at 771).
Furthermore, “both the ‘motive and knowing falsity must unite in the same person.’” Id.


suspended. (See id. ¶¶ 52, 57;

see also Pl.’s Surreply at 4.)

       Thus, as explained fully below, even if the allegations in the amended complaint

are taken as true, they establish that the cause of the critical adverse employment action

(Horsey’s suspension) was Horsey’s own declination, not race discrimination. In

addition, the complaint’s bald assertion that Horsey “endured discrimination that was

pervasive and regular[] (in the form of emails, phone calls, and letters[] threatening

[his] employment)” (Am. Compl. ¶ 58)—without further description or discussion—is

manifestly insufficient to support any reasonable inference that State subjected Horsey

to a hostile work environment in violation of Title VII. Therefore, both Title VII

counts in Horsey’s amended complaint fail to state a claim as a matter of law and must

be dismissed.

    2d at 91. And the amended

complaint does not allege that State’s mandate that Horsey himself undergo an

evaluation—as distinct from Horsey’s refusal to undergo an evaluation—caused a

significant change in Horsey’s employment status. See Spellman v. Ohio Dep’t of

Trans., 244 F. Supp. 3d 686, 702 (S.D. Ohio 2017) (“forced psychological evaluation”

not an adverse employment action for purposes of Title VII discrimination claim);

Missick v. City of New York, 707 F. Supp. 2d 336, 348 n.5 (E.D.N.Y. 2010) (same for

medical evaluation); Bazile v. City of New York, 215 F. Supp. 2d 354, 386 (S.D.N.Y.

2002) (concluding that referral for psychological evaluation was not adverse

employment action “[a]bsent any showing of a significant impact on [plaintiff’s]

working conditions—or, indeed, any impact”); cf. Baum v. Rockland Cty., 161 Fed.

App’x 62, 64 (2d Cir. 2005) (finding that the


actions that appears in Horsey’s amended

complaint is likewise insufficient to support Horsey’s intentional discrimination claim,

because none of them is alleged to have occurred “because of” Horsey’s race, as Title

VII requires. See 42 U.S.C. § 2000e-2(a). In other words, Horsey’s amended complaint

fails to raise a plausible inference that State was motivated by race, even in part, when

                                            16
it made these other employment decisions. See Univ. of Sw. Tex. Med. Ctr., 570 U.S. at

370.

       With respect to the most obviously adverseplaintiff must allege “that she was discriminated against because of her

                                             23
status”) (internal quotation marks, citation, and alteration omitted)). As noted in

Section III.A.2, supra, with the exception of Horsey’s allegation that State required

him, an African-American employee, to undergo a mental evaluation, when it did not

require the same of his Caucasian co-worker, Horsey’s amended complaint is entirely

devoid of allegations that State subjected him to harassment or abuse because of his

race. See Jones v. Billington, 12 F. Supp. 2d 1, 12 (D.D.C. 1997) (finding that a


with those of cysteine proteinases. Finally, a novel technique is described which uses purified human alpha-2-macroglobulin to trap, purify and characterize proteases from amebic lysates. The results obtained with this technique confirm those of the overlay technique, since both methods reveal four distinct proteinases in the two different amebic preparations examined.a couple of weeks. We have had company, and I have done a lot of early morning fishing followed by a full day of work.

This morning it took a little longer than normal to get my Applepeels post done and it was about eleven am before I started mowing. It was something over 85 degrees Fahrenheit with the humidity at 100% when I started mowing.

I mowed a couple of rounds and felt a bite on my ankle. My wife who was talking to our neighbor didn't hear me ask her to bring me some itch gel so after a couple of trips around the yard, I stopped and went in and put some gel on the bite.

I started the mower up and began another round. By the time


Q:

Can someone explain to me why clear:both and margin-top cannot work in the same div

I have already came across some explanations, including stackoverflow, but unfortunately, I still can't understand perfectly what is the cause of it.
So, can someone please explain it in a simple way?
Here is a question similar to what I'm asking but I didn't understand what is the cause. It fixed my problem, but I just want to know why.
margin-top not working with clear: both
Thanks

A:

A margin is a minimal distance between an element and other elements in the same context. Floated elements are basically completely "taken out of context". They don't count for margin calculations. Any element calculating its position relative to other elements based on margins ignores floated elements entirely. So it's not that clear:the L3 and L4 spinous processes, and the ligamentum flavum of L3-4 was also removed depending on the extent of the laminectomy. All models had continuity of the proximal posterior ligament complex between the L2 spinous process and the remaining L3 spinous process ([Fig. 1](#F1){ref-type="fig"}).

A posterior pedicle screw fixation was simulated in the L3-4 intertransverse process fusion. All screws had sharp threads to prevent relative motion at the bone-screw interface and were inserted into the anterior third of the vertebral body through the pedicles. The pedicle screws did not violate the medial wall of the pedicle or the endplates. With the exception of the screw tip, the remaining surface of the screw was fixed to the bone without allowing relative motion. A \"tie\" contact condition was used to


case of an absolute sale of said patent as herein provided, all rights in and to the same shall pass to said second party.'"
The character of the provisions in the remaining fifteen clauses of the instrument appears sufficiently in the following extract from the findings of the master to whom the case was referred:
"Le Clair granted to Sauerman the exclusive right to manufacture, use, and sell scrapers under his patent in the United States and foreign countries and to grant to others the same right,
"Le Clair reserving the right to terminate the contract in case of failure by Sauerman to pay royalties;
"Sauerman granted to Le Clair a license, without royalty, to make and sell scrapers to consumers only in the states of California, Washington, Arizona, Nevada, and Oregon;
"Le152, 9 S. Ct. 463, 32 L. Ed. 888, there was an assignment with a provision in the instrument of which the court said:
"The concluding provision, that the net profits arising from sales, royalties, or settlements, *77 or other source, are to be divided between the parties to the assignment so as to give the patentee one-fourth thereof, does not, in any respect, modify or limit the absolute transfer of title. It is a provision by which the consideration for the transfer is to be paid to the grantor out of the net profits made; it reserves to him no control over the patents or their use or disposal, or any power to interfere with the management of the business growing out of their ownership."
The case of Littlefield


you do so, you call printf() on the buffer, with a %s parameter... which prints the argument as a sequence of characters until it reaches the terminating null (i.e. %s prints a string).
If you want to print a single character, use %c. If you want to print to the buffer character by character until you reach the null, do it manually - but snprintf() is designed so that you don't have to do that.
Using snprintf() in a more common manner:
#include<stdio.h>

int main() {
  char data[5] = {'a', 'b', 'c', 'd', '\0'};
  // or char data[] = "abcd";

  char buff[100] = {0};
  snprintf(buff, sizeof buff, "%s", data);
  printf("%s String here\n", buff);
  return 0;
}

Copy/print each character manually:
#include<stdio.h>

int main() {
  char data[5] = {'a', 'b',illegally, but I
want to point out it's a really incredible
innovation that has tons of legal and other
legitimate use cases.
Most importantly being that it made it possible
for regular people with regular devices to
be able to host files, and I just think that's
so cool.
So what if we took this approach and we applied
it to the web?
Websites are just files after all.
If a website is just a collection of files,
then what a if we could use a peer-to-peer
networks to get a website from one computer
to another?

Chinese:
也许其中一些设备类似于服务器
毫无疑问地存在于云中的设备
有时某些设备会脱机，但是
最大的想法是常规设备可以提供帮助
为托管文件贡献资源
网络？
这真是个大问题。
现在，我相信大多数人都知道BitTorrent
因为它的耻辱。
它主要用于下载电影
和非法的音乐和其他媒体，但我
我想指出它真是令人难以置信
具有大量法律和其他方面的创新
合法用例。
最重要的是它使它成为可能
对于有常规设备的普通人来说
能够托管文件，我只是认为那样
非常酷。
那么，如果我们采用这种方法并且我们应用了
它到网上？
网站毕竟只是文件。
如果网站只是一个文件集合，
然后，如果我们可以使用点对点
网络从一台计算机获取网站
到另一个？

Chinese:
事实证明你可以，我真的很兴奋
告诉你更多相关信息。
我和这两个家伙一起工作 -  P Frazee和
Macintosh电脑。
他们今天都在这里。
我们三个人一起研究一个项目
叫做Beaker浏览器。
Beaker是一个实验性的浏览器，意思是
我们并不总是遵循网络标准。
但这不是因为我们不认为他们是
重要的是，我们只进行了一些实验
记住我们想跑，我们想
它们是值得运行的，即使它们是
不符合标准。
我们正在运行的核心实验是什么
当您采取其中一个点对点时发生
网络，你把它放在浏览器里面？
所以，我们希望保持网络大致相同，
保持浏览器非常熟悉，但制作
它是同行的。
我们处于一个非常幸运的位置
做这个实验。
因为Macintosh是核心开发者
一个名为Dat的对等协议

English:
It turns out you can, and I'm really excited
to tell you more about that.
I work with these two guys — P Frazee and
Macintosh.
They're both here today.
Together, the three of us work on a project
called the Beaker browser.
Beaker is an


matter what your technical expertise is,
it's a web you can contribute, build, and
share.
I think that makes it a worthwhile experiment
to run, not just in Beaker, but in every single
browser.
Thank you so much for imagining with me.
[Applause].
[Cheering and Applause]

Chinese:
我想以此结束并从根本上说，
点对点网络是一个更有趣的网络，
无论您的技术专长是什么，
这是一个你可以贡献，构建和
分享。
我认为这使它成为一个有价值的实验
不仅在Beaker中运行，而且在每一个单独运行
浏览器。
非常感谢你想象我。
[掌声]。
[欢呼和鼓掌]
popularity due to their relatively richer information content (Hirshfield et al., [@B39]; Liu Y. et al., [@B53]; Liu T. et al., [@B52]; Keles et al., [@B48]; Aghajani and Omurtag, [@B1]; Buccino et al., [@B12]; Omurtag et al., [@B66]). Available evidence indicates that brain activity measures of MWL are more informative than ocular or peripheral physiology measures (Hogervorst et al., [@B40]).

Concurrent EEG and fNIRS, which we refer to as EEG+fNIRS, is promising as a practical technique that is more accurate than the individual modalities alone. fNIRS provides information that is complementary to EEG, by measuring the changes in cerebral blood flow (CBF) and related hemoglobin concentrations through near-infrared light source/detectors on the scalp. It is comparable to EEG in portability. fNIRS does not have electromyographic (EMG) and blink artifacts


(Fazli et al., [@B25]; Liu Y. et al., [@B53]; Tomita et al., [@B92]; Buccino et al., [@B12]). In this study, we built on this work to explore the unique properties of EEG+fNIRS for MWL detection.

The *n*-back task was introduced by Kirchner ([@B51]). *n*-back is a continues-performance task for measurement of WM capacity, which has been used frequently in the field of cognitive neuroscience. Gevins (Gevins et al., [@B32], [@B31]; Smith and Gevins, [@B80]) and Smith (Smith and Gevins, [@B81]) showed during high task-load conditions EEG theta activity increases in the frontal midline and alpha activity attenuates during the performance of an *n*-back task. In addition, fNIRS revealed WM load while performing *n*-back task activates PFC (Ayaz et al., [@B4]; Sato et al., [@B78]; Fishburn et al., [@B26]; Herffin two different wavelengths (760 and 850 nm). Oxy- and deoxyhemoglobin concentration changes (HbO and HbR) were computed using the modified Beer-Lambert law (Sassaroli and Fantini, [@B77]) using standard values for the chromophore extinction coefficients and differential path-length factor (Keles et al., [@B50]). fNIRS might be contaminated with the movement, heart rate, and Mayer wave artifacts. In order to reduce these artifacts while retaining the maximum possible amount of information, a band pass filter of 0.01--0.5 Hz was applied to fNIRS signals. After the preprocessing step, two subjects were excluded from the rest of analysis due to the poor quality of the signal and excessive noise. The processed signals were inspected visually for the presence of muscle and motion, eye movements, and other artifacts. The recordings that were


rank the set of features. The testing data were projected into the PC space that was obtained from the training data and the testing features were ranked by using the same method. In part of our analysis, we have chosen to reduce the number of features of the systems (EEG, fNIRS, and Hybrid) by truncating all systems at the same fixed size, eliminating the lowest ranked features. The labeled training examples were fed into a binary linear SVM. Each training example contained a vector of feature values in a given window and its label that denoted one of the two classes of interest. The SVM constructed an optimal hyper-plane creating a decision surface maximizing the margin of separation between the closest data points belonging to different classes (Aghajanimean of the repetitions. In addition to overall accuracy, confusion matrices yield a very detailed overview of a classifier\'s performance. Usually, the confusion matrix is further summarized by some proportions extracted from the confusion matrix. The main metrics are (a) sensitivity of class A (Sens.~A~) which describes how well the classifier recognize observations of class A, (b) specificity of class A (Spec.~A~) which describes how well the classifier recognizes that an observation does not belong to class A, (c) positive predictive value of class A (PPV~A~) tells us given the prediction is class A, what is the probability that the observation truly belongs to class A?, (d) negative predictive value of class A (NPV~A~) tells us given a prediction does not belong to class A, what is the


computed by first applying a simple triangular moving average filter covering three samples at each step, and then a cubic spline interpolation. The figure shows that the theta and alpha bands of EEG are positive during 0- and 1-back, although they become negative for 2- and 3-back tasks. The positive peak of HbO increases from 0- to 2-back and has a slightly lower peak for 3-back compared to 2-back. The figure also shows that the Hybrid features (such as NVO in the delta range) generally resemble the corresponding uni-modal features (such as HbO and PSD in the delta range) however they were dominated by neither, suggesting that the Hybrid feature contained additional information.

![Grand block average of normalized features from 5 s windows: **(a)** PSD (delta, theta, alpha bands)between system type and subject, while the differences in accuracy between the Hybrid and the uni-modal system was significant with a *p* \< 0.001.

Table [4](#T4){ref-type="table"} lists the sensitivity (Sens.), specificity (Spec.), positive predictive value (PPV), and negative predictive value (NPV) for each individual class within a classification case. For example for the case of {Rest v 3back}, each one of rest and 3-back classes would have a Sens., Spec., PPV, and NPV, respectively. In addition, this table summarizes all these metrics for EEG, fNIRS, and Hybrid systems in order to make it easier to compare between their capabilities.

######

Sensitivity (Sens.), specificity (Spec.), positive predictive value (PPV), and negative predictive value (NPV) are listed in percentage (%) for all classification cases (binary and multi-class) and all systems (EEG, fNIRS,


effects. Studying the performance and neural correlates of MWL for subsets of our data could reveal differences in the beginning and at the end of the study. This would also require an additional investigation of statistical validity, and was not attempted. The statistical significance of the results of our study was demonstrated through a two-way ANOVA that showed significant differences in the accuracy of the Hybrid v uni-modal systems. However, we have not investigated whether a smaller group of subjects would still yield a significant result. We have investigated the capabilities of various subsets of the types of features that were available. It would also be illuminating to investigate the classification accuracy of subsets of the full array of our sensors. Such information can help design more compactthe relation[@green]: $(1+q)/2 = \beta ^2/2$ (in quon theory, $-1 \le q \le 1$, where $q=-1$ corresponds to fermions and $q=1$ corresponds to bosons, so that here $q$ must be close to -1 and $(1+q)/2$ must be very small, because we are dealing with electrons). Moreover, we used this parametrization for an easy comparison of our results with the RS experiment, which utilized the same formalism. To determine the experimental limit on $\beta^{2}/2$ from our data, we used the same arguments of Ramberg and Snow: see references and for details of the analysis. Finally we find[@PLA]: $$\frac{\beta^{2}}{2} \leq 4.5 \times 10^{-28} \mathrm{ ~at \; 99.7 \% \; CL.}$$ Thus in this first run in the Frascati laboratory we have already improved the limit obtained by Ramberg and Snow


of all powers that be, let us reconsider our stance regarding the policy of drug prohibition. In this hundred year effort to prevent the use of certain flowers and plant extracts we have empowered criminal elements worldwide to the tune of $400 billion per year. The US has arrested 39 million non-violent drug users at a cost of more than one trillion dollars. Despite the horrors the US inflicts on its own people in the name of drug war, it is the citizens of Mexico that bear the deadliest weight of this prohibition.

Thousands of Mexicans are butchered each year in the name of fighting this first of America's eternal wars; the pipe dream of men who have long since died and whose followers continue their efforts to destroyprograms. Listen live at 6:30 CENTRAL time at http://www.kpft.org or tune in to one of our 72 affiliate stations in the US and Canada or check it out on Monday morning on our website http://www.drugtruth.net.

Denver DEA Special Agent in Charge, Jeffrey Sweetin says "Technically, every dispensary in the State [Colorado] is in blatant violation of federal law." "The time is coming when we go into a dispensary, we find out what their profit is, we seize the building, and we arrest everybody. They're violating federal law; they're at risk of arrest and imprisonment." [per AP, Denver Post, and the Boulder Daily Camera, pg. 1 , 2/14/2010].

This is in direct contradiction to your campaign promise, your "Holder Memo," and the Colorado State Constitution. This hypocrisy is not the government


behavior that we demand of our elected leaders. A bit of consistent honesty should be a reasonable voter expectation.

SAC Sweetin has forgotten for whom he works, and requires an appropriate public reminder, whether that is a transfer, a public reprimand or a firing. His personal, incorrect belief, that "marijuana is not medicine" is ill-informed, and irrelevant to his job description, unless he insists on bringing his personal unscientific bias into his job, blatantly disregarding his office, his chain of command, and the Constitutions of Colorado and of the United States. As a part of the Executive Branch of our government, I believe that he works for you, Sir.

Friday, February 12, 2010

Today marks the opening ceremonies of the 2010 Olympics in Canada. Right now there are huge numbers ofamong others.
Electronic systems often include a number of processing resources (e.g., one or more processors), which may retrieve and execute instructions and store the results of the executed instructions to a suitable location. A processor can comprise a number of functional units (e.g., herein referred to as functional unit circuitry (FUC)) such as arithmetic logic unit (ALU) circuitry, floating point unit (FPU) circuitry, and/or a combinatorial logic block, for example, which can execute instructions to perform logical operations such as AND, OR, NOT, NAND, NOR, and XOR logical operations on data (e.g., one or more operands).
A number of components in an electronic system may be involved in providing instructions to the functional unit circuitry for execution. The instructions may be generated, for instance, by a processing resource such


as updated from time to time. There may be more than one API, and in this Agreement the term is both singular and plural.

“API Documentation” means the documentation, data and information that we provide regarding the use of the API through the Developer Website.

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"Personal Information" is any information pertaining to a directly or indirectly identifiable individual.

"SDK" means the Hootsuite Software Development Kit, including the documentation and endpoints, and all associated technologies, libraries, content, features, documentation and any other materials, tools, and systems.

“Supported Platform(s)” means the social networking site(s) supported by the Hootsuite Platform, including Twitter, Facebook, LinkedIn, Google +, Instagram and other social networking sites described at www.hootsuite.com.

“Third-Party Services” means online, web-based applicationssummary of features, screenshots, user guide, and links. Your Content must at all times be accurate and not misleading.

c) We have the right to review, accept and reject your App and any and all proposed developments to the App by you. After our initial review and approval of your App, we reserve the right to periodically conduct subsequent reviews. Any future updates to your App must also be brought to our attention for review before being added to the production version of the App. We reserve the right, in our sole discretion and for any reason at any time, to revoke our permission.

3.3 Design Requirements. To ensure your App works well within Hootsuite, and with other apps available on the App Directory, you should build your App within


is not responsible for providing your App and any related support, warranty, etc.

Your App TOS must comply with the terms of use imposed by any applicable Supported Platform(s). You are required to stay up to date on such applicable terms of use.

c) Service Level Agreement. You must provide support for your App on terms set out in a published service level agreement (SLA).

d) Privacy Policy. You must have in place a privacy policy that meets applicable legal standards and accurately describes the collection, use, storage and sharing of Personal Information. You must promptly notify us of any breaches of your App TOS or privacy policy that impact or may impact Users. Your privacy policy must be at least as stringent and user-friendly as ours.

4.3 Compliance with Applicable Laws.by a governmental authority.

e) No Other Storing. You may not copy or store any Data or capture or store any information expressed by the Data (such as hashed or transferred data), except to the extent permitted by this Agreement.

4.8 Prohibitions. You must ensure that your App:

a) does not violate or infringe the intellectual property rights of any third party;

b) does not include adult content, promote gambling or involve the sale of tobacco or alcohol to persons under 21 years of age, or is in our judgment, harassing, defamatory, abusive, lewd, obscene or is otherwise objectionable;

c) does not contain or introduce Malicious Software; and

d) is not designed or utilized for the purpose of spamming Users.

5. Licenses

5.1 License from Hootsuite to You. Subject to the terms and conditions of this


Agreement, we grant to you a non-exclusive, non-transferable, non-sublicensable, worldwide, revocable right and license during the Term to market and sell your App through the App Directory.

5.2 License to Brand Features. We grant to you a non-exclusive, non-transferable, non-sublicensable, worldwide, revocable right and license during the Term to our Brand Features for the sole purpose of promoting your App in accordance with our Brand Guidelines (as they may be updated from time to time) and conditions below. This license may be revoked by us at any time.

You shall always ensure that you represent your App as your own and not an officially supported Hootsuite App. You can say that your App is integrated with Hootsuite or use names like “My App for Hootsuite”, but you can’t otherwise useall steps that we consider appropriate, including warning, investigating or terminating or suspending your rights under this Agreement. In addition to any other available remedies, we may, in our sole discretion, seek specific performance, an injunction and legal costs. We reserve the right to take corrective action as we see fit if we receive complaints from Users about your App or your actions.

10. Developer Personal Information and Usage Data

10.1 Developer Personal Information. Hootsuite may reveal personal information about you for attribution purposes, handling inquiries from Users or potential Users, and other purposes we reasonably deem necessary under this Agreement and pursuant to our Privacy Policy.

10.2 Usage Data. We may also collect, use, process and store diagnostic and usage-related content from computers, mobile phones or other devices with respect


if both parties jointly wrote it. It shall be governed by the laws of British Columbia, Canada except for conflicts of laws principles. Any litigation arising under or relating to this Agreement must be brought exclusively in a court in Vancouver, British Columbia, and by accepting this Agreement you attorn to the jurisdiction of such court.

15.2 Severability. If any provision of this Agreement is found to be illegal, void, or unenforceable, the unenforceable provision will be modified so as to render it enforceable to the maximum extent possible in order to effect the intention of the provision; if a term cannot be so modified, it will be severed and the remaining provisions of this Agreement will not be affected in any way.

15.3 Language. Where Hootsuite has provided youWith the development of information technology and the popularity of network technology, people increasingly use various types of image collection equipments in daily lives, such as a surveillance camera, a digital camcorder, a network camera, a digital camera, a cell phone camera and a video sensor of Internet-of-Things, to acquire a large amount of images and video data. Rapid and intelligent analysis of such a large amount of images and video data is urgently needed.
Facial identification technology can analyze images and video data intelligently. Race, gender and age are three major properties for facial identification because these properties describe a social background, behavioral principles and a living status of a person. These major properties can be reflected on a person's face. A solution is needed regarding how to


G+C content RNA; positions shown relative to full length λ DNA template (black line). 1K = a 1025-nt subsegment of 6L. 416, 130 and 40 are subsegments of 1K. Gray lines denote ssRNAs. A predicted nucleic acid triple helices target site in the 40nt RNA is bold and underlined within the total sequence.](gkw758fig1){#F1}

MATERIALS AND METHODS {#SEC2}
=====================

Apparatus {#SEC2-1}
---------

The magnetic tweezers apparatus was set up as previously described ([@B13]). The magnets were held in a lateral position with respect to a microchannel containing the sample on a three-axis translation stage to exert a force perpendicular to the glass surface to which the dsDNA was bound. The magnitude of the force applied on the beads was determined by the distance between the magnet and the glass surface. The calibration of theDNA polymerase (NEB). For short transcripts (\<0.3 kb), incubation of amplification reactions was extended to 24 h. Long RNAs were purified by phenol-chloroform extraction and ethanol precipitation, and dissolved in DEPC-treated water. Short RNAs (130 and 416 nt) were purified by gel electrophoresis on a Criterion 10% polyacrylamide TBE--urea gel (Bio-Rad), precipitated with ethanol and redissolved in DEPC-treated water. The shortest RNA (40 nt) and other oligonucleotides used in this study were purchased from Integrated DNA Technologies. Oligonucleotide sequences are listed in Supplementary Table S1.

Interaction reaction {#SEC2-3}
--------------------

Interaction experiments were carried out in a square micro-cell (Vitrotubes; 0.8 mm) containing a round inner capillary (Vitrotubes; 0.55 mm in diameter) closed at its ends. The inner capillary was modified by adsorption of 1 mg/ml streptavidin in PBS (phosphate-buffered saline) pH


with the dsDNA prior to defining its force extension response. For such analysis ([@B13]; Figure [1A](#F1){ref-type="fig"}), the two ends of full-length λ dsDNA are differentially labeled, one with biotin and the other with digoxigenin. The digoxigenin-labeled end can attach specifically to an anti-digoxigenin coated capillary, and the biotin-labeled DNA can attach specifically to a streptavidin coated magnetic bead. Force is imposed to extend the λ dsDNA by adjusting the position of a magnet. For experimental analyses, an RNA species of interest is present in the capillary chamber prior to the application of force; control experiments for λ dsDNA in the absence of RNA were also performed. Imposition of force moves the bead away from the surface of the capillary (Figure [1A](#F1){ref-type="fig"}). The bead/surface distance measured by using anhave been used to immunize mice. Sera from these animals have been evaluated in the SMFA but none have shown high levels of oocyst inhibition in this assay. 3.) Assess the presence of asexual and sexual stage parasites in residents of Kenieroba, Mali throughout the year. In the spring of 2013 we initiated a new study (NIH 13-I-N107) of malaria transmission to address the limited information on transmission in malaria endemic areas, and in 2014 we completed the field aspect of this study. Volunteers representing all age groups were finger pricked twice per month for 1 year to collect DNA and RNA. During the 2014-2015 year we completed analysis of over 10,000 samples of parasite DNA on filter paper. In October 2013 (middle of the wet season), P.


died at the scene, while Few continues to recover.

READ MORE: AG's Office: No more criminal indictments expected in Mardis case

READ MORE: Judge releases body cam video of shooting of Jeremy Mardis

READ MORE: Civil lawsuit: Jeremy Mardis 'suffered immensely' after 'barbaric' shooting

Greenhouse's trial is scheduled for June 12.

The state, represented by the Louisiana Attorney General's Office, had filed four motions regarding Stafford's case that were heard Friday. The hearing on one was continued, and the defense team of Jonathan Goins and Christopher LaCour reached an agreement with the state on another motion regarding challenges during jury selection.

Most of the discussion revolved around a motion that sought to exclude opinion testimony from the defense's expert witnesses. State law forbids expert witnesses from giving testimony on a defendant's guilt or innocence,been going on?" Amanda parried. "I assure you, life is plodding along much the same as it always has."

"You are a poor liar," Sophia informed her serenely, seating herself on the settee. "Amanda, I must remind you that Windsor is hardly isolated from town. We do hear of goings-on in London, and there have been rumors concerning you and a certain gentleman."

"Rumors?" Amanda regarded her with surprised dismay.

"And you look different."

"Different?" In her sudden consternation, Amanda could only flush guiltily and repeat her sister's words like some addled parrot.

"There is a look about you that makes me suspect that the rumors are true. You are indeed carrying on some kind of liaison with someone, aren't you?" Sophia pursed her lips as she regarded her younger sister. "Obviously it


Fretwell puffed in companionable silence while he contemplated what he could say to his friend. The truth was, Devlin looked like the very devil. The past few weeks of ruthless work and drinking and lack of sleep had finally taken their toll. Fretwell had never seen him in such a state before.

Devlin had never struck him as a particularly happy sort of man, seeming to view life as a battle to be won rather than something he should find a measure of enjoyment in, and given his past, no one could blame him. But Devlin had always seemed invincible. As long as his business concerns were succeeding, he was charmingly arrogant, nonchalant, reacting to good news and bad with sardonic humor and a steady head.

Now, however, it wassurvey included measurements of a genetic marker called telomeres – they noticed something unusual.

Telomeres are molecular regions that act as caps on the ends of our chromosomes, helping to protect the genetic information in our cells from deteriorating over time – and, hypothetically, from exposure to things that are harmful to our health.

In that vein, telomere length is taken as a marker of how old we are on a cellular level, with longer telomeres considered better to have, since shorter telomeres have been associated with outcomes like cancer, heart disease, and cognitive decline.

Now, we might have something new to add to that list: childbirth.

In the study, the team found that once they'd adjusted for things like age, ethnicity, education, smoking status, and so on, women who had given


Collections: {}
    Views: {}
    Routers: {}
    initialize: ->
            new Voice.Routers.Posts()
            Backbone.history.start()
$(document).ready ->
    Voice.initialize()

app/assets/javascripts/application.js
//= require jquery
//= require jquery_ujs
//= require underscore
//= require backbone
//= require voice
//= require_tree ../templates
//= require_tree ./models
//= require_tree ./collections
//= require_tree ./views
//= require_tree ./routers
//= require_tree .

javascripts/routers/posts_router.js.coffee
class Voice.Routers.Posts extends Backbone.Router
    routes:
            '': 'index'
    initialize: ->
            @collection = new Voice.Collections.Posts()
            @collection.fetch()
    index: ->
           view = new Voice.Views.PostsIndex()
            $('#container').html(view.render().el)

javascripts/views/posts/posts_index.js.coffee
class Voice.Views.PostsIndex extends Backbone.View

    template: JST['posts/index']

    initialize: ->
            @collection.on('reset', @render, this)

    render: ->
            $(@el).html(@template(posts: @collection))
            this

app/assets/templates/posts/index.jst.eco

 BACKBONE WORKS

<%= @posts %>

javascripts/collections/posts.js.coffee
class Voice.Collections.Posts extends Backbone.Collection
    url: '/api/posts'
    model: Voice.Models.Post

javascripts/models/post.js.coffee
class Voice.Models.Post extends Backbone.Model

config/routes.rb
Voice::Application.routes.draw do
    match '/login' => 'session#create'
    get 'logout', to: 'session#destroy', as: 'logout'
    resources :users


damaging material on Hillary Clinton, Trump’s Democratic opponent.

The plan came to nothing, however, when the visitor turned out to be a lobbyist pitching relief for US sanctions on Russia.

Some Democrats sought to prepare Trump’s political foes for disappointment.

“Once we get the principal conclusions of the report, I think it’s entirely possible that that will be a good day for the president and his core supporters,” Sen. Chris Coons (D-Del.), a member of the Senate Judiciary Committee, said to party members on a Saturday conference call organized to strategize their next steps.

Others kept fanning the collusion flames.

“You have a president who in my opinion, beyond the shadow of a doubt, sought to, however ham-handedly, collude with the Russian government, ― a foreign power,” presidential hopeful Beto O’Rourke said onTV has struck aggregation deals with a roll call of content providers - including new arrivals Apple+ and Disney+.

It is also making more money from digital advertising as marketers shift budgets from commercial TV to streaming, reflecting the cord-cutting trend among viewers.

Revenues grew by 59% in the second quarter to $250 million at Roku, which roughly broke even at the bottom line. The company forecasts revenues of just over $1 billion this year.

With Roku now aggregating more than 7,000 channels, it is promoting its own Roku Channel that offers a recommendation engine to help viewers filter the vast amount of programming on offer to find what they want to watch.

“Our goal is to be the leading streaming platform for households,” said Wood, seeing a future in which there


and the ’minirank’ row samples ranks every 1024 positions instead of 512 by default. $^*$The column “*Const. time*” indicates the construction time in seconds. In the case of [[*BBhash*]{}]{}, the first value is the construction time using eight CPU threads and the second value in parenthesis is the one using one CPU thread. $^{**}$The column “*Const. memory*” indicates the RAM used during the [`MPHF`]{}construction, in bits/key and the total in MB in parenthesis. $\dagger$ The memory usages of EMPHF and EMPHF HEM reflect the use of memory-mapped files (`mmap` scheme).[]{data-label="MPHFPERF"}

&

  ---------------
      Const.
   memory$^{**}$
  ---------------

  : Performance of different [`MPHF`]{}algorithms applied on a key set composed of $10^9$ 64-bits random integers, of size 8GB. Each time result is theby simplicity: the method only relies on bit arrays and classical hash functions. While the idea of recording collisions in bit arrays to create [[`MPHF`]{}]{}s is not novel [@chapman2011meraculous; @lu2006perfect], to the best of our knowledge [[*BBhash*]{}]{}is the first implementation that is competitive with the state of the art. The construction is particularly time-efficient as it is parallelized and mainly consists in hashing keys and performing memory accesses. Moreover, the additional data structures used during construction are provably small enough to ensure a low memory overhead during construction. In other words, creating the [`MPHF`]{}does not require much more space than the resulting [`MPHF`]{}itself. This aspect is important when constructing [[`MPHF`]{}]{}s on large key sets in practice.

Experimental results show that [[*BBhash*]{}]{}generates [[`MPHF`]{}]{}s that are slightly larger than those produced by


bamboo steamer with a lid inside it. Bring the water to a boil over high heat. Place a dampened cheesecloth or towel over the bamboo rack and spread the rice on it, leaving a 2.5cm border all around to let the steam through. Fold over the cheesecloth (or kitchen towel), cover the steamer securely with the lid, and steam until the rice is translucent and tender but firm (about 20 minutes).

Bring the coconut milk to a boil in a small pot over high heat. Reduce the heat to medium low, add the sugar and salt, and stir until both are completely dissolved.

Dissolve the tapioca starch with two tablespoons water and using a whisk, quickly stir it into the coconut milk. Allow the coconut milk sauce to thicken (aboutfancy features to get the recursion scheme. (As a side note, there's no reason to parameterize the Lit data type.)
The fold is:
newtype Fix f = In { out :: f (Fix f) }

gfold :: (Functor f) => (f a -> a) -> Fix f -> a
gfold alg = alg . fmap (gfold alg) . out

To specify the algebra (the alg parameter), you need to do a case analysis against ExprF, but the alternative would be to have the fold have a dozen or more parameters: one for each data constructor. That wouldn't really save you much typing and would be much harder to read.  If you want (and this may require rank-2 types in general), you can package all those parameters up into a record and then


not be sick of those words, you're a strong man indeed. I wanted to vomit after just an hour of it. That's not helped by Vannile, whose Australian warblings and high-pitched wailing manages to make an already ludicrous story sound even worse.

The worst crime committed by Final Fantasy XIII's narrative, however, is the total lack of impetus provided to care. There's no depth to anything or anyone, and as a result, the player has no reason to be involved. Why should the player care about saving Cocoon, when Cocoon isn't fleshed out in any way? With only the occasional glimpse at Cocoon's society and culture, we have no motivation for saving it. The characters talk about saving their world as if it's important, but to the player, Cocoon'sBen Savage has posted the above Matthews family photo, presumably from one of the episode tapings, to his Instagram. The picture shows the whole Matthews gang (complete with a very Topanga-esque headband on Danielle Fishel), as well as some of the other actors who’ll fill out the rest of the show.

For those who need up-to-the-minute news about the show, the recently launched Twitter account @GMWWriters is a peek inside the writers room – and that group sure knows how to tease. A recent tweet asked, “Happy New Year! Who would you invite to a Matthews holiday episode? Because we’re writing one. And there are lots of seats at the table.” Dare. To. Dream.

A few weeks ago, the account also seemed to hint at an appearance by Minkus or


(more likely) apparently-not-dead Mr. Turner with the tweet, “Today we decided who the first guest star returning from Boy Meets World will be….Shawn? Eric? Really? So fast? Don’t you want to start on the other side of the school?” (In the Boy Meets World episode “Graduation” Minkus called out to an unseen Mr. Turner, who had apparently been on “the other side of the school” for the past season.)percent of bites (envenomations) results in “dramatic skin lesions” that often become necrotic, and that approximately one percent of the time can cause a systemic reaction that may result in death.

Notice all those qualifiers in the previous paragraph? They’re there for a reason, and it’s a reason that Vetter returns to repeatedly in The Brown Recluse Spider. For while it is indeed, along with the Black Widows, Latrodectus mactans and Latrodectus hesperus, a “medically significant” spider, its bite is not nearly as lethal or even as frequently debilitating as the popular media from the middle of the Twentieth Century right on up to today have convinced so many of us that it is.

It’s a topic to which Vetter devotes considerable attention; an entire chapter, in fact – “Human


clearing weeds most likely as I was using hoe when the incident occurred. I remember […]

You Have to DigNovember 23, 2017Much like scents, flavors can have remarkable powers over our minds. Even a small taste of just the right flavor can, as Proust so eloquently described – at length – in his À la recherche du temps perdu, unlock a veritable treasure chest of memories. For myself, it’s the flavors from my childhood that seem […]but Xa has MS and MUST have access to seating.We spent too much time having to go back to our hotel so she could sit down and rest.

The advice from the staff for getting a seat in the other venues was 'ask someone to let you have their seat and explain that you are disabled' to which the seated people's reply was usually 'Fuck off, it's not MY problem'. Nice 'punk unity' in action.


Q:

How to prevent inheritance of any css style of parent node to child node?

Assume a body node having a child node (e.g. div).
There may be css styles attached to the body, which are not known in advance (they are specific to an arbitrary page accessible on the WWW).
The child node (e.g. div) has a bunch of css styles which are static.
How to prevent css styles of the parent to "influence" styling of the child?

A:

There is no generic way. You need to set a value (other than inherit) for every property that has inherit as the default value.
Even that won't prevent all influence.
e.g.
 body { width: 300px; }
 div  { width: auto;  }

The width of the div is influenced by the width of theSciences (AAFS). No one may be interested in the word dissertation either, but be aware this could be part of a PhD program. Depending on whether students are enrolled full- or part-time, a PhD typically takes between three to seven years to complete.

Becoming a CSI in the Treasure State

CSI provides a different way to enter the forensic science field. Instead of working in a lab, it gives individuals the opportunity to be out in the field actually collecting and preserving evidence and also keeping a scene secure to prevent evidence contamination. Crime scene investigators need to obtain a variety of skills related to the criminal justice system, including how to present evidence in court, which is why an education is so important. Common paths to enter CSI include:

Option


preferred by some hiring agencies. Learn more about programmatic and institutional accreditation further down on this page. Some forensic science options in Montana include:

Flathead Valley Community College, in Kalispell, offers an associate degree in forensic science that can later be used to transfer to the University of Montana at Missoula. The 78-credit program includes organic chemistry, college physics, college chemistry, calculus, and other courses, but can be modified for specific forensic science tracks available at the University of Montana.

The University of Montana, in Missoula, offers a certificate in forensic studies for students who may be later interested in pursuing a bachelor’s degree. The certificate is 18 credits and includes introduction to forensic science and forensic science beyond the crime lab. The UM program also requires students to take(1) Field of the Invention
The present invention relates to a compiler that converts a source program described in a high-level language such as C++ language into a machine language, and especially to optimization by a compiler.
(2) Description of the Related Art
A high-performance compiler that can exploit effectively a high function that a processor has is much sought after as the function of the processor is greatly improved in recent year. In other words, the compiler that generates effectively advanced and specific instructions that the target processor executes is demanded.
For example, a processor that executes operation instructions in various fixed-point formats required for media processing such as digital signal processing and a high-performance processor that executes SIMD (Single Instruction Multiple Data) type instructions are developed. The compiler that targets


he voluntarily

turns over to third parties")            Pursuant to that doctrine, the

Supreme Court has separately held that the government need not

obtain a warrant to obtain recordings of voluntary conversations

surreptitiously captured via radio transmitter, see United States

v. White, 401 U.S. 745, 752-53 (1971), records from banks, see

United States v. Miller, 425 U.S. 435, 444 (1976), and certain

phone call data from pen registers, see Smith, 442 U.S. at 745-

46, because the information at issue in each instance had been

voluntarily disclosed by the defendant to a third party, see id.

at 743-44.

             Hood does not dispute that he voluntarily disclosed the

information to Kik that he now seeks to suppress.                 - 8 -
pursuant   to   18   U.S.C.   §   2703   --    of    his     cell-site        location

information ("CSLI") from his wireless telecommunications carrier

that had been sent to cell towers by his cell phone and stored by

that carrier.    138 S. Ct. at 2211-12.             The CSLI data acquired in

Carpenter depicted the defendant's movements across nearly 13,000

specific location points during a 127-day span.


the phone.

Id. at 2211-12.

            Thus, the government's warrantless acquisition from Kik

of the IP address data at issue here in no way gives rise to the

unusual concern that the Supreme Court identified in Carpenter

that, if the third-party doctrine were applied to the acquisition

of months of Carpenter's CSLI, "[o]nly the few without cell phones

could escape . . . tireless and absolute surveillance."               Id. at

2218. Accordingly, we conclude that Hood did not have a reasonable

expectation of privacy in the information that the government

acquired from Kik without a warrant.         This conclusion, moreover,

is in accord not only with the rulingsthe Fifth Amendment

"privileges [individuals] not to answer official questions put to

[them] in any other proceeding, civil or criminal, formal or

informal, where the answers might incriminate [them] in future

criminal proceedings." 465 U.S. 420, 426 (1984) (quoting Lefkowitz

v. Turley, 414 U.S. 70, 77 (1973)).             But, we agree with the

government that our decision in United States v. York, 357 F.3d

14, 25 (1st Cir. 2004), requires us to reject this facial challenge

to the condition of supervised release at issue.

            The condition that Hood challenges requires that he

"submit to periodic random polygraph examinations as directed by

the probation officer to assist in treatment and/or case planning

related   to


■ Medical societies sign a letter warning Congress that a 23% reduction could force some physicians to limit the number of Medicare patients they treat.

Washington -- Preventing a 23% Medicare physician payment cut is one of several major tasks Congress faces when members return Nov. 15. The American Medical Association and dozens of other medical societies are reminding lawmakers that stopping the reduction before it takes effect on Dec. 1 is crucial to keeping Medicare sustainable.

The AMA, 65 national medical societies and 24 state societies sent a letter to Congress on Sept. 29 asking members to stabilize Medicare physician pay, at least through 2011. Congress adopted short-term delays of the cuts several times in 2010, including once after contractors for the Centers for Medicare & Medicaid Services beganmore breathing space when units are in the workshops for routine maintenance or repairs – they have also had diesel units away for refurbishment over recent months.

One other solution the company has adopted is running traditional carriages pulled by locomotives that are up to 50 years old between Norwich, Great Yarmouth and possibly Lowestoft.

A long-term solution could be the electrification of the cross-country route from Felixstowe through Bury St Edmunds to Ely and Peterborough, with a branch to Cambridge.

shares

6 comments

So no actual plan to do anything then. I guess this is down to there being no single national strategy for running transport services and no focus on what is in the best interest of the travelling public.

My god, you would think they are running a charity rather with


Ghana Languages (BGL)

Ghana Museums and Monuments Board (GMMB)

National Theatre of Ghana
National Theatre Company of Ghana
National Symphony Orchestra
National Dance Company

National Folklore Board

Kwame Nkrumah Memorial Park

W. E. B. Du Bois Memorial Centre for Pan African Culture

Pan African Writers' Association (PAWA)

Affiliated organizations

Institutions
College of Art and Social Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi
School of Performing Arts, University of Ghana, Legon
Institute of African Studies, University of Ghana, Legon
Centre for Cultural and African Studies, KNUST, Kumasi
Department of Archaeology, University of Ghana, Legon

Associations (Arts)
Ghana Association of Visual Artists (GAVA)
Musicians Union of Ghana (MUSIGA)
Ghana Union of Theatre Association (GHATA)
Ghana Association of Writers (GAW)
Ghana Dance Association (GDA)
Ghana Concert Parties Union (GCPU)
Ghana Culture Forum (GCF)

Relations with international bodies
UNESCO
KwaZulu Natal Provincial Government South Africa
The British Museum, U.K.
African, Caribbean and Pacific Countries (ACP)

Vision
The vision of this1. Introduction {#S1}
===============

For millennia, medicinal plants have been a valuable source of therapeutic agents, and still many of today\'s drugs are plant-derived natural products or their derivatives ([@R232]; [@R312]). However, since natural product-based drug discovery is associated with some intrinsic difficulties (discussed in more details in Section 2.1), pharmaceutical industry has shifted its main focus toward synthetic compound libraries and HTS for discovery of new drug leads ([@R38]; [@R94]). The obtained results, however, did not meet the expectations as evident in a declining number of new drugs reaching the market ([@R94]; [@R233]; [@R384]). This circumstance revitalized the interest in natural product-based drug discovery, despite its high complexity, which in turn necessitates broad interdisciplinary research approaches ([@R176]). In line with this, the Austrian "Drugs from Nature Targeting Inflammation (DNTI)"


(1st century AD), and by the Romans Pliny the Elder (1st century AD) and Galen (2nd century AD) ([@R407]). The Arabs preserved a large amount of the Greco-Roman knowledge during the Dark and Middle ages (i.e., 5th to 12th centuries), and complemented it with their own medicinal expertise, and with herbs from Chinese and Indian traditional medicines ([@R87]). The invention of letterpress by Johannes Gutenberg led to a resurrection of the Greco-Roman knowledge in the 15th and 16th century, and to the compilation of several very influential herbal books that were widely distributed in Europe, like *The Mainz Herbal* (*Herbarius Moguntinus*, 1484) and *The German Herbal* (1485), both edited by Gutenberg\'s partner Peter Schöffer, the *Herbarium Vivae Eicones* (Otto Brunfels; 1530), the *Kreütter Buch* by Hieronymus Bock (1546)the compound was only accessible from the bark of the western yew (*Taxus brevifolia* L.). This was on one hand problematic because the whole production process including tedious bark collection and drying, extraction, and purification was very time-consuming. On the other hand, concerns on the ecological impact of intensive bark collection were raised ([@R88]; [@R233]). Although taxol is meanwhile accessible via alternative routes (see Section 4.2), the problem of sustainable supply of herbal material still frequently occurs. Cultivation would be a more sustainable alternative to wildcrafting, nevertheless, approximately two thirds of the 50,000 medicinal plant species used world-wide are still wildcrafted ([@R62]). Therefore, institutions like WHO ([@R467]) and European Medicines Agency (EMA) ([@R113]) developed guidelines on good agricultural and collection practices (GACP) for medicinal plants in order to


costs for small molecule drugs, and their increasing use is putting a rising pressure on national health insurances. Furthermore, the high prices of this type of pharmaceuticals is not expected to quickly drop in the near future after patents expiration, because biological generics (biosimilars) require additional clinical bioequivalence studies to be approved for use and overall have significantly higher development and manufacturing costs in comparison to small molecule generics. Therefore, to relive the increasing financial burden, turning back to some "old" small molecule-based approaches is conceivable ([@R24]).

Due to the challenges described above, the interest in natural product-based drug discovery has been gradually declining. Even in the last decade, many big and medium-sized pharmaceutical companies, which were still active in the area in the 1990s, terminated their natural productoften overlap. Due to high sample numbers in such libraries, compounds to be investigated further are often selected quickly, mainly based on potency values ([@R384]), although a negative correlation of cell-free *in vitro* potency and favorable ADME/T (absorption, distribution, metabolism, excretion/toxicity) is likely ([@R146]).

The plant kingdom includes a high number of species, producing a diversity of bioactive compounds with different chemical scaffolds. According to previous estimations only 6% of existing plant species have been systematically investigated pharmacologically, and only around 15% phytochemically ([@R87]; [@R117]; [@R440], [@R441]). Although today the percentage of better characterized species is likely higher due to ongoing research efforts, it is still conceivable that there is a huge number of plant compounds that are not well investigated pharmacologically in the approximately 310,000 plant species described