       for i in range(5):
                self.assertEqual(("D" + str(i)).encode(), sess.run(get_next))
            with self.assertRaises(errors.OutOfRangeError):
                sess.run(get_next)

    def test_kafka_wrong_global_configuration_failed(self):
        """Tests for KafkaDataset worng global configuration properties."""
        topics = tf.compat.v1.placeholder(dtypes.string, shape=[None])
        num_epochs = tf.compat.v1.placeholder(dtypes.int64, shape=[])

        # Add wrong configuration
        wrong_cfg = ["debug=al"]
                   self.assertEqual((channel + str(i)).encode(), sess.run(get_next))
            with self.assertRaises(errors.OutOfRangeError):
                sess.run(get_next)

        # Reading from `test_e(time)e` we should get the same result
        dataset = kafka_io.KafkaDataset(
            topics=["test_" + channel], group="test", eof=True
        )
        iterator = dataset.make_initializable_iterator()
        init_op = iterator.initializer
        get_next = iterator.get_next()


    init_op,
                feed_dict={topics: ["key-partition-test:1:0:5"], num_epochs: 1},
            )
            for i in range(5):
                self.assertEqual(
                    (("D" + str(i * 2 + 1)).encode(), (b"K1")), sess.run(get_next),
                )
            with self.assertRaises(errors.OutOfRangeError):
    every tech industry in history, it’s typically dominated by males, [but] as it becomes more creative, more females come into it.” He continued, saying, “everyone I know, all the major developers, directors… they’re all very encouraging for women.” Addressing former NFL punter Chris Kluwe’s claim that #GamerGate is a hate group, the developer stated that he “just fundamentally reject[s] that idea.”

“Most of the developers I know seem to be very pro-GamerGate. And what I mean by that is, again, they want journalistic ethics, they want their games reviewed fairly,” he explained. “They want to not go through having to jump through hoops. They just want people to look at, talk about, and enjoy their games.”

Dyack has reason to be critical of the gaming press. A 2012 article from


1; $prev = $new; take $new; # last if $prev == 1; } } say $sequence.join(", ");

File: collatz (fixed)

Running it:

$ collatz 23 23, 70, 35, 106, 53, 160, 80, 40, 20, 10, 5, 16, 8, 4, 2, 1 $ raku collatz 5 5, 16, 8, 4, 2, 1 $ raku collatz 4 4, 2, 1 $ raku collatz 3 3, 10, 5, 16, 8, 4, 2, 1 $ raku collatz 2 2, 1 $ raku collatz 1 1

Looking good.

Challenge #54.3: Extra Credit

Have your script calculate the sequence length for all starting numbers up to 1000000 (1e6), and output the starting number and sequence length for the longest 20 sequences.

unit sub MAIN (Int $limit = 1_000_000, :$verbose, :$chop = 20); # [1] my %length; # [2] for 1 ..$limit # [3] { my @list = collatz($_); # [4] %length{@list.elems}.push($_); # [5] say "_ $_ -> @list[]" if $verbose; } my $count = 0; # [6] my $elems; # [7] for %length.keys.sort({ $^b <=> $^a }) -> $l # [8] { $elems = %length{$l}; # [9] for @$elems # [10] { last if $count++ >= $chop; # [11] say "{ $count }: Number $_ (with length $l)"; # [12] } } sub collatz ($start) # [13] { my $sequence := gather { take $start; my $prev = $start; loop { last if $prev == 1; my $new = $prev %% 2 ?? $prev / 2 !! 3 * $prev + 1; $prev = $new; take $new; } } return $sequence; }

File: collatz-1e6

[1] The first argument is positional.


Vehicles are generally equipped with audio devices which play an audio sound inside a cabin. JP2776092B and JP1993-085288A disclose audio devices which perform localization of an audio sound so that person(s) on board is able to hear the audio sound from a given position in a cabin.
Incidentally, a vehicle driver is required to focus on driving (a traveling state of a vehicle which changes as the vehicle is driven) when enjoying driving a sports car, etc. Meanwhile, the driver tends to want to enjoy an audio sound for relaxation during steady travel.reflections on personal tragedy. The album was released in early 2008. The PuSh International Performing Arts Festival in Vancouver commissioned part of the writing of the album.

In 2009, Hille independently released Do You Want What I Have Got?, a collection of live recordings of songs from Hille's theatre scores. Then in 2011 she released  Young Saint Marie, a collection of songs written by Buffy Sainte Marie and Neil Young, recorded live and in studio with the CBC Radio Orchestra and her band, with arrangements by Giorgio Magnanensi of Vancouver New Music Society.

Hille is the in-house composer for Theatre Replacement; she collaborates with them on at least one show per year. She scored Bonnie Sherr Klein’s NFB film Shameless: The ART of Disability, as well as producing records


Kim Barlow
Piano and accompanying vocals on Dan Mangan's song The Indie Queens Are Waiting (2009)

References

External links

 Interview in Being There magazine, January 2007
 Review of Return of the Kildeer album Blogcritics magazine, May 2007

Category:1968 births
Category:Living people
Category:Canadian singer-songwriters
Category:Canadian pop pianists
Category:Canadian women pianists
Category:Musicians from Vancouver
Category:Canadian indie pop musicians
Category:20th-century Canadian singers
Category:21st-century Canadian singers
Category:Canadian female pop singers
Category:20th-century women singers
Category:21st-century women singers
Category:21st-century Canadian pianistsCEO of AnitaB.org, an advocacy group for women in technology. If Silicon Valley wants to make the world better for everyone and make deep learning systems that actually understand the real world, then it must assemble and empower teams who reflect the world at large and can see flaws in the massive datasets that lenders, employers, and criminal justice practitioners rely upon. “I’m very concerned with the people who are negatively impacted,” Darden Wilkerson said.

OpenTable CEO Christa Charles also offered a quick and painless benchmark to check how you’re advancing your diversity goals. “Tell us last quarter’s hires. Sometimes it’s hard to [share] a number overnight when you don’t feel like you’re making progress, so just tell us how you did last quarter,” she said at the summit.


marriage. The U.S. Mission to the U.N says the new rule simply brings visa rules in line with policy in other government departments.

The rule goes into effect next month and will include part-time and seasonal employees. The company had been under fire for its low disparity, particularly in certain communities.“We listened to our critics, thought hard about what we wanted to do, and decided we want to lead,” Bezos said in a statement. “We’re excited about this change and encourage our competitors and other large employers to join us.” As a reminder African Americans, Latinx and women make up a disproportionate number of people making below minimum wage in the U.S., often in jobs that are likely to be replaced by automation.

Hundreds of asylum-seeking kids that were beingon September 11. It’s part of what makes this small group so poignant. The Sikh Motorcycle Club was founded by five New Jersey men, their ranks have swelled to 28. They show no swagger displayed by outlaw motorcycle gangs of American legend, instead they feel affirmed by proximity to others who share the same faith and minority status. “The bikers ride together in a single line, with more experienced riders in front and at the tail end. These riders haven’t taken the mufflers off their engines; they don’t cut in front of cars; they don’t claim the road. They just ride.”


TRIAL COURT ERRED IN GRANTING SUMMARY JUDGMENT

BASED ON A FINDING THAT PLAINTIFFS DID NOT DEMONSTRATE THAT ANY

ATTENDANT       CIRCUMSTANCES         EXISTED      THAT   WOULD     PRECLUDE       THE

APPLICATION OF THE OPEN AND OBVIOUS DOCTRINE.”

                                              I.

      {¶11} In their First Assignment of Error, appellants contend the trial court erred

in granting summary judgment in                                              6

record indicate that there are at least several inches of flat, closely-cut grass or mulch

on either side of the sidewalk. Although there is a lamppost in the grassy area and

some nearby shrubbery, no shadows from such objects are cast on the spot where the

concrete joint is located. In her deposition, Sharon answered in the affirmative when

asked if she would have been able to see the raised portion of the concrete had she

looked down. Id. at 56-57.

      {¶18}


of evidence-based active learning in their courses, "mid-range" consisted of faculty who engaged students within their lecture using some approach, e.g., an interactive lecture, and the lecture group was for faculty who were believed to lecture without the use of techniques to engage students. Of the 22 faculty we observed, 6 were in each of the lecture and mid-range groups, and 10 were in the active group.

Courses observed and inter-rater reliability
--------------------------------------------

Each of the 22 classes was observed live by a pair of observers, with those pairs selected based on their availability to observe a particular class. Class sizes were representative of STEM class sizes at JMU; twelve classes had between 12 and 36 students, there were two classes of approximately 60, and eight classes of over 100 students.the instructor insight into the types of questions students will ask (helping with their preparation for future iterations of the course), and give the instructor who may be uncomfortable answering on the spot the opportunity to construct responses.

### Lecture to standing clickers/IF-AT

The main difference between *lecture* and *standing clickers/IF-AT* is the use of clickers or IF-ATs (some sort of immediate feedback mechanism), but there is no moving among groups (MG). Faculty development could be focused in the area of using either of these technologies, although with the advent of multiple apps for collecting real-time responses, there does not *need* to be a "university supported" technology. One of the criticisms that often arises with the use of clickers is in the area of inclusivity, the assumption that everyone can


and 3) the effects of steroid hormones and cytokines on SAL1 mRNA levels. SAL1 was localized to glandular epithelial cells (GE) in the endometrium during the estrous cycle and pregnancy, with the highest level of SAL1 expression on D12 of pregnancy. In addition, SAL1 protein secretion into the uterine lumen was detected in uterine flushings on D12 of the estrous cycle and pregnancy, with higher levels on D12 of pregnancy. SAL1 protein, but not SAL1 transcript, was also detected in the conceptuses on D12 and D15. In explant culture experiments, SAL1 mRNA levels in the endometrium were increased by interleukin 1beta. The results of a GE- and implantation stage-specific expression and uterine secretion of SAL1 in the porcine uterus suggest that SAL1 present at the maternal-fetal interface mayand For Stay of Execution.[3]
Specifically, Mann's motion alleges two grounds for relief: "First, prior counsel filed a two-issue petition for writ of habeas corpus, which neglected to raise substantial and meritorious claims on Mann's behalf. Second, prior counsel failed to protect Mann's right to appellate review of this Court's denial of the petition ... by failing to file a timely notice of appeal or an appropriate motion for extending the time for filing the notice of appeal."

2. RELIEF FROM PRIOR JUDGMENT
Mann is, without question, entitled to relief under Rule 60(b) in order to perfect an appeal from this Court's judgment of October 20, 1987. Indeed, one of the very purposes of Rule 60(b) is to prevent litigants from being deprived of their day in court because of inadvertent,


a major thrust of Penry's evidence as mitigating evidence. We do not see how the evidence of Penry's arrested emotional development and troubled youth could, under the instructions and the special issues, be fully acted upon by the jury. There is no place for the jury to say `no' to the death penalty based on a principal mitigating force of those circumstances." (First emphasis added.)
[11]  The state claims this issue is precluded by the "contemporaneous objection rule." However, Mann's trial attorneys did file a motion to dismiss the capital murder charge on the ground that it "denies the Defendant his Constitutional right to produce mitigating circumstances which would lessen his punishment for the charge or offense which the jury has previously found him guilty of committing." (Transcript,'four years of continuous rape' starting at age eight.

'She described that her father would sit on the bed afterward and cry as he prayed with her,' the congregation's elders wrote in a letter to religion's global headquarters in New York, The Watchtower Bible and Tract Society.

The Watchtower Bible and Tract Society's former Brooklyn headquarters is seen. A new document trove sheds light on how the group handled explosive child sex allegations

Known simply as The Watchtower, the group then based in Brooklyn exercises strict control over Jehovah's Witness congregations worldwide.

The elder daughter said that the abuse began in 1974, when she was five years old, claiming that her father would tie her naked and spread-eagle to her bed.

'[She] expressed that though never actually penetrating her, he did repeatedly touch


photosensitive drum by reducing the potential of the photosensitive drum by means of pre-transfer exposure, the ability of the transfer sheet to separate from the photosensitive drum may be adversely affected by the setting of the transfer bias of the transfer apparatus.
The transfer bias has charge attributes that are of opposite polarity to that of the toner adhering to the photosensitive drum and may, for instance, be impressed from the underside of the conveying belt that carries the transfer sheet. However, if too much charge is injected into the conveying belt, the transfer sheet lying on the surface of the conveying belt may get charged, and its polarity is reversed. Same polarity in the transfer sheet and the photosensitive drum causes the transfer sheet and the photosensitive drumsome of the toner adhering to the photosensitive drum and the toner being transferred back to the leading edge of the transfer sheet from the separating pawl.
Scum is not limited alone to the leading edge of the transfer sheet. When the entire surface of the transfer sheet adheres to the photosensitive drum and is conveyed while in contact with the separating pawl, not only does an unwanted stripe appears on the portion of the transfer sheet that is caught on the separating pawl, the unfixed image transferred to the transfer sheet is also faint.
The effect of residual charge on the surface of the photosensitive drum is explained next. Until the time neutralization is completed in the cleaning stage, the photosensitive drum retains a certain amount of charge in


Seifert said it has been "a uniting force" for anti-pipeline activists across the country and "showed us that [TransCanada] can very easily change the route."

The group is currently planning its largest demonstration yet for Jan. 7 somewhere in Texas. It also plans to increase its presence in Oklahoma, where construction is also underway.

TransCanada, meanwhile, is trying to obtain permanent injunctions against protesters in Wood County, where Winnsboro is located. Court orders would prohibit activists from interfering with pipeline construction. A temporary restraining order is in effect until a hearing takes place on Jan. 4, Dodson said. The company is pursuing a similar process in neighboring Franklin County.

3 Protesters Still in Jail

The biggest of the group's 12 protests happened on Nov. 20 at two Keystone XL sites in Nacogdoches,another spokesperson for the Tar Sands Blockade, said Bishop "speaks to the heart of what a lot of Texas landowners are going through right now."

"We support him and his lawsuit, and his voice is a powerful one."


Joyce Holland (The Muscatine Mummy). Muscatine, IA, Dr. Alphabet's Medicine Show, at The Belle of the Bend Art Fair, August 24, 1974.
	Week-long Novel (The Great American Novel Marathon). Iowa City, IA: World Writer's Week, October 21–28, 1974.
	Balcony Poem (untitled). Iowa City, IA: Second CHAOS Art Festival, November 24, 1974.
	Poem Wrapping a City Block (Poetry City, U.S.A.). Iowa City, IA: Sculpture Festival, October 6, 1975.
	Poem on Stage (untitled). Iowa City, IA: Duck's Breath Mystery Theater Farewell Show, December 18, 1975.
	Quadrangle Poetry Panorama (untitled). Newton, PA: Buck's County Community College, September 24, 1976.
	Blindfolded Poetry Marathon (The Dark Side). New Hope, PA: New Hope Arts Festival, September 25, 1976.
	Poem Whitewashed on Dubuque St. (Alphabet Avenue). Iowa City, IA: Nonesuch Fair Art Festival, Blackhawk Minipark, April 23, 1977.
	Poem Rising to the Ceilingimportant consideration in the treatment of opioid dependence among adolescents and young adults. Erikson argued that successful therapy should result in not only diminished symptoms, but also increased ego strengths \[[@B23]\]. Thus, assessment of a patient\'s ego strength in conjunction with overall character can serve to guide effective treatment \[[@B33]\].

Psychosocial models of recovery place emphasis on redefining identity and striving toward an "ideal self" \[[@B34]\]. This sense of self and purpose appears to be delayed in opioid dependent youth. As adolescents of differing developmental stages likely respond differently to intervention efforts, customizing treatment programs according to level of maturity may serve to maximize efficacy \[[@B20]\]. Evaluation of ego strengths among opioid dependent adolescents and young adults may serve to inform tailored intervention efforts to effectively address the growing


 The panel unanimously concludes this case is suitable for decision
without oral argument. See Fed. R. App. P. 34(a)(2).
review de novo the district court’s interpretation of statutory provisions, Ponsford

v. United States, 771 F.2d 1305, 1308 (9th Cir. 1985), and for an abuse of

discretion the district court’s decision regarding the sufficiency of service of

process, Rio Props., Inc. v. Rio Int’l Interlink, 284 F.3d 1007, 1014 (9th Cir. 2002).

We affirm in part, reverse in part, and remand.

      The district court did not abuse its discretion by denying the Gages’ motion

to dismiss for lack of jurisdiction and their request to stay the levy action because

the Gages failed to establish invalid service of process. See SEC v. Internet

Solutions for Bus. Inc., 509 F.3d 1161, 1163 (9th Cir.This invention relates to a memory system for a computer. It relates particularly to a word organized, random access, read-write or read-only memory of the kind having a semiconductor array with a data field and a data check field for detecting data errors in each word. The invention is applicable also to memory arrays other than semiconductor arrays, for example, core memory and other types of bit storage means. The memory word may represent more than one data word in a particular computer.
The present invention is applicable to a memory system of the kind in which a processor module is associated with one or more memory modules.
The memory system of the present invention permits data errors, addressing errors and operation errors to be detected.
Errors in stored data can


Q:

How to use a custom column in a Mvccontrib Grid Model?

I am using a ASP.NET MVC 3 Mvccontrib grid like so:
@Html.Grid(Model).Columns(column =>
{
  column.For(x => x.UserId).Named("ID");
  column.For(x => x.Name);
  column.Custom(@
@item.Name
).Named("Name");
  column.For(x => x.Score).Named("Score");
})

But now I need to move this into a custom grid model:
@Html.MvcContrib().Grid(Model).WithModel(new MyGridModel()).Sort(ViewData["sort"] as GridSortOptions).Attributes(id => "grid", style => "width: 100%;")

with corresponding grid model:
public class MyGridModel : GridModel<MyModel>
{
  public MyGridModel()
  {
    Column.For(x => x.UserId);
    Column.For(x => x.Name);
    Column.For(x => x.ImageUrl);
    RenderUsing(new HtmlTableGridRenderer<MyModel>());
  }
}

But how can I do my custom column in my grid model?
Column.Custom(???);

A:

Try like this:
public class MyGridModel : GridModel<MyModel>
{
    public MyGridModel()
    {
      started to gain a negative reputation. Consumers are fed up with being spammed; and as a result, they are deleting, unsubscribing and disengaging. However, just because marketing automation includes “automation” in its name, it doesn’t mean that every communication powered by marketing automation technology is broadly blast to all consumers."

"One surefire way to guarantee an unwavering, effortless customer experience is to minimize your brands biggest areas of failure. Do this by pinpointing where your customer experience falls short and produce meaningful solutions that will salvage customer relationships during a time of need. By understanding where you can improve your CX, organizations can work to eliminate these failures in order to turn negative experiences into positive ones," said Paige O'Neill, CMO, SDL."

"Mark Lancaster doesn‘t consider himself an entrepreneur, but


employees to meet customers' needs."

"While the good is expected, the bad will go viral. Keeping this in mind, organisations must have an integrated strategy in place that caters to each individual consumer and empowers employees to meet customers’ needs."

"With the rapid adoption of tablets, smartphones and accessible Wi-Fi, today’s generation of internet consumers live in a time of instant gratification. Instant gratification coupled with more competing content has led consumers to become more discerning and ruthless."

"Whether consumers are traveling for business or leisure, the travel process itself shouldn’t be an added inconvenience. Yet, when it comes to family holiday planning, more than a quarter (27%) of Brits find the planning, booking and preparation a source of great stress."

"The insights gained through my experience in strategically building brand awarenessthe perfect elevation for the Furniture counter tops romina cleopatra baby furniture isn’t just a tricky matter. The purpose is that you have to concentrate around the height of the men and women who usually do the activity in the Furniture. The ideal measurement for Ventianni convertible crib to twin by romina furniture will be just like the high of their waistline. But on account of the variation of this human body, the high waist additionally is varied. It can be stated the ideal height of this Furniture table is about 80 90 cm. It’s likely that we’re not overly bent and the arms will be more comfortable when inhale or stirring while still cooking. Thus, to use the Furniture gas stove with 2 stoves or single stove,


Articles relating to People | sergei lavrovhttp://www.news24.com/Tags/People/sergei lavrov
Argotic Syndication Framework, http://www.codeplex.com/argotichttp://www.rssboard.org/rss-specificationMon, 19 Mar 2018 16:43:08 +0200US, North Korea in kindergarten fight' - LavrovRussian Foreign Minister Sergei Lavrov has described the rhetoric between leaders of the United States and North Korea as a "kindergarten fight between children" and urged calm.https://www.news24.com/World/News/us-north-korea-in-kindergarten-fight-lavrov-20170923
Trump asks Russia to rein in Syria's Assad, IranUS President Donald Trump has called on Russia to rein in Syrian President Bashar al-Assad and his key ally Iran.https://www.news24.com/World/News/trump-asks-russia-to-rein-in-syrias-assad-iran-20170510
Russia ready to assist Kurds and US on Raqa offensiveRussia's Foreign Minister Sergei Lavrov says Moscow iss ready to co-ordinate with a Kurdish-Arab alliance and the US-led coalition in an assault on the ISIS Syrian bastion of Raqa.https://www.news24.com/World/News/russia-ready-to-assist-kurds-and-us-on-raqa-offensive-20160524
US and Russia reach provisional deal on Syria truceA Syria peace truce announcement follows statements byrule hacktool_multi_pyrasite_py
{
    meta:
        description = "A tool for injecting arbitrary code into running Python processes."
        reference = "https://github.com/lmacken/pyrasite"
        author = "@fusionrace"
    strings:
        $s1 = "WARNING: ptrace is disabled. Injection will not work." fullword ascii wide
        $s2 = "A payload that connects to a given host:port and receives commands" fullword ascii wide
        $s3 = "A reverse Python connection payload." fullword ascii wide
        $s4 = "pyrasite - inject code into a running python process" fullword


Bulgarian league system. In 1985 the team earns it promotion back to A RFG.

1985-2000
After its return to the top division in 1985 the team makes a steady performance for over a decade, placing itself in the middle of the league table until the late 1990s. During that time the team finishes in top 3 only once - in season 1991-92.

In the late 1990s the form of the team worsens which takes them out of the elite again, and in seasons 1998-99 and 1999-00 Lokomotiv Plovdiv plays in B PFG.

Georgi Iliev Years (2000-2004)
In 2001 the club is bought by Georgi Iliev. At that time, Iliev owns another football club  - Velbazhd Kyustendil. The team from Kyustendil has a very good performance in the Bulgarian top division (A PFG)very high CV risk group. Patients from both groups need to be intensively treated with high doses of statins, often accompanied by ezetimibe \[[@cit0008]\]. According to many experts, HeFH is currently underdiagnosed and undertreated \[[@cit0012], [@cit0013]\]. Using currently available treatments, the recommended targets for LDL-C concentration are difficult to achieve in the majority of patients. This calls for the consideration of a new therapeutic approach.

Although we presently know the frequency of HeFH in the Polish adult population, there is still a lack of data on the clinical practice of FH management \[[@cit0001], [@cit0005]\].

In an effort to address this gap in knowledge, we present a retrospective observational study on patients with FH treated in a specialized outpatient metabolic clinic, including data on therapy regimen and treatment goal attainment according


Changes in lipid levels {#sec3.3}
-----------------------

Throughout the observation period, the average concentrations of LDL-C, total cholesterol (TC), and triglyceride (TG) in the overall study population decreased significantly by 52.6%, 40.5%, and 17.95%, respectively (*p* \< 0.001) ([Table IV](#t0004){ref-type="table"}). Conversely, hypolipidemic therapy had no effect on the serum concentration of high-density lipoprotein cholesterol (HDL-C). Except for a significantly greater reduction in TC and TG in the subpopulation of men vs. women (--44.8% vs. --39.2% (TC) and --28.6% vs. --14.3% (TG), respectively; *p* \< 0.05; [Table IV](#t0004){ref-type="table"}), no gender-specific differences in the hypolipidemic profile were found.

######

Serum concentration of lipids -- LDL-C, TC, TG, and HDL-C -- at the inclusion visit and last follow-up visit in the overall population andthe therapy period and the mode of therapy used varied within our study cohort.

In conclusion, this was the first observational study in a Polish patient population treated for HeFH by routine clinical management. The results revealed that therapy based on EAS/ESC guidelines was suboptimal for a significant number of patients. The intensification of therapy is based on the physician's decisions and patient agreement. Patients are often afraid of adverse events related to higher doses of statins, particularly after reading leaflets \[[@cit0024]\]. The combination therapy of statins and ezetimibe could be applied to a large number of patients to better address their needs. However, in some patients from our study, the cost of therapy was an obstacle.

Nonetheless, despite adherence to high-intensity therapy with statins in combination with ezetimibe, some


kiosks at several locations.

Restaurants that take advantage of new technologies in thoughtful ways may be not only to cut costs and boost efficiency, but also expand their capacity.

6. Rest stop upgrade: the Tesla Supercharger drive-in

Every day across the United States, weary travelers and truck drivers pull off the highway and into rest stations, where they step out to stretch, take a break from their journeys, and eat a hot meal.

It’s a quaint picture. Too quaint, if you’re Elon Musk:

Source: Twitter

Musk’s idea — building a novelty throwback restaurant at a Tesla Supercharger location — gives an interesting glimpse into how an electric vehicle future might reconfigure the often-derided yet classically American rest stop experience.

“We can just have the menu pop up as soon as you put the car intoamplifier known in the art includes an optical amplifying medium to which signal light to be amplified is supplied and means for pumping the optical amplifying medium so that the optical amplifying medium provides a gain band including the wavelength of the signal light. For example, an erbium doped fiber amplifier (EDFA) includes an erbium doped fiber (EDF) as the optical amplifying medium and a pump light source for supplying pump light having a predetermined wavelength to the EDF. By preliminarily setting the wavelength of the pump light within a 0.98 .mu.m band or a 1.48 .mu.m band, a gain band including a wavelength of 1.55 .mu.m can be obtained. Further, another type optical amplifier having a semiconductor chip as the optical amplifying medium is also known. In


signal power is eliminated. Conversely, gain equalization may be performed in such a manner that the interchannel deviation in signal power is permitted and the interchannel deviation in optical SNR is suppressed as shown in FIG. 4B.
In either case of the conventional gain equalization method, attention is paid to only one of the signal power and the optical SNR, and gain equalization is performed on either subject. As a result, the conventional gain equalization method has a problem caused by a deviation remaining in the other of the signal power and the optical SNR. For example, in the case of performing gain equalization on the optical SNR deviation as shown in FIG. 4B, a deviation remains in the signal power, causing a problem in system construction such thattimes stronger than , while for the dimeric [2K](+) the corresponding increase in binding is 51 (Cl(-)), 84 (Br(-)), and 22 (I(-)) times with the same stoichiometric ratios as observed for the ion pair complexes in the solid-state.


people," said Phillips. "Because they're actually seeing on the ground, visually, these bees and these butterflies and the birds visiting the property, and they see that they can make a significant difference."

A Few Simple Rules

Even small changes can make a difference to the environmental impact of lawns. The "entry-level option," according to Philips, for families that still want room for their kids to play, is to inject more wildflowers into the turf. That includes plants that are typically viewed as nuisances.

"The stuff that people are usually trying to get out of their lawn, we're saying 'No, that's good to have in your lawn!'" said Philips. "So reintroduce native violets -- and even dandelions -- certain clovers, low-growing thyme and things that flower, which provide pollinator benefits and areoverstays claiming green cards. For example, the agency has set rules for determining when a person starts accumulating “unlawful presence” days, which quickly become an automatic block to green-card applicants.

The most likely people to overstay their visas are the relatively few visitors from poor countries, such as Chad, the Solomon Islands or Angola.

However, students are the most likely category of visitor to overstay, largely because they can easily blend into the U.S. society. The report said roughly 69,000 foreign students overstayed their visas in 2017:

For nonimmigrants who entered on a student or exchange visitor visa (F, M, or J visa), DHS has determined there were 1,662,369 students and exchange visitors scheduled to complete their program in the United States. However, 4.15 percent stayed beyond the authorized window for


to work. Trying to get as much info as possible I came across the following command:

systemd-analyze critical-chain

Running this will give you output similar to:

This output gives you info on the system’s history. It also shows you where you are currently in the system, what is and isn’t available to you at different times during the startup sequence (file system, wifi, users etc) and how long each part of the sequence takes to start up. I figured that if I moved my service from sysinit.target to basic.target the timing difference would be negligible from a user point of view and I’d probably have more resources available.

Basic target was described as pulling-in all local mount points plus /var, /tmp and /var/tmp, swap devices, sockets, timers, path units and other basicmade for a dedicated security station, something normally only seen on capital ships. The officer at the tactical systems station (who can also control sensors, security, and navigation, according to Chapter 9.04 of Star Trek Adventures) can make use of an equipment Trait called Tactical Analysis. This has a Cost: Escalation 1 (see p. 184 of Star Trek Adventures).

Runabouts can also have pods which are external equipment on a “roll-bar” mounted to the top of the vessel. As seen in the image above, this changes the profile of the runabout but adds considerable ability to the craft. As with modules, a runabout can only have one pods installed at a time.

Communications: When an officer uses the Hailing Frequencies Open , Respond to Hail , or Intercept Tasks (see


closely and you'll see that those are ghostly heads right above the Fudge Shoppe; because right around the corner it's...

That's right. A spook show in the middle of town. Grim Reapers and Mennonite ladies sharing the same sidewalk!

The brochure above is from '86. I finally got the nerve to go inside in '92. A small audience stays seated as ghostly effects play out around the room. In following with standard Spook Show procedure there's a "blackout" at the end and glowing ghosts swirl about the darkened chamber. (At least that's how it happened back in the day.) Here's a shot from 2002...

I find it interesting that they've since returned to all white signage. But that's just me. Anyway, even the non-ghostly stuff is pretty great. The Pancake Pantryhere's how it looked a few weeks ago...

I realize they're everywhere now, but my fondest G-burg attraction will always be the Ripley's Believe it or Not museum. It was the second one constructed (1970) and the first one I ever set foot in (I'm up to eight now). I was heartbroken when I returned in '92 to find it freshly destroyed by a fire (along with a haunted house called House of Seven Gables). But Ripley's reopened in 1995 and it's twice as big now. Here's another '80s pamphlet...

And one from later on...

And here's a current shot of the museum...

The town seems to be turning into Ripleyburg nowadays. There's the Ripley's 4-D theater, two Ripley's mini golf courses, two lackluster Ripley arcades, the Ripley's Haunted Adventure...

Photo from 2002

and


back when.) There were just too many places selling too many classic jokes to resist. But these days it seems as if retail racks of gags and magic are an endangered species. So it was nice to discover this display (bearing my own package designs no less!) in an Ober puzzle shop...

The second previously uncharted amusement that I finally conquered is called World of Illusions...

If you inspect this old pamphlet closely you can see how the place used to look. (It had sort of an athletic club elegance) If you compare it to the modern snapshot below you'll notice the exterior now boasts a slew of modifications.. the faux airplane, some colorful flags, dayglow yellow paint, a string of lights and a magician that never shows up inside...

Seejust posted some great 1970s Gatlinburg brochures! Check them out here.

P.S. I just ordered Tim Hollis' new book on the pre-1980s Smokey Mountain tourist scene. Can't wait for it to arrive...

20 comments:

Swanky
said...

You were in my 'hood. I worked in the Gatlinburg area for years and years. I got in free most of those places and spent a day going through and marveling at how poor they were. There are still a lot of the vintage places scattered about, but it is harder and harder to tolerate the crap to try to see the good stuff.

We all wonder what brings the gazzillion people to Pigeon Forge and Gatlinburg each year. Sometimes the traffic is backed up for 4 hours to get in there (a 20 minute drive). Go carts


when I saw it 30 years earlier... It was still kind of creepy accidentally too.

If Ripley's aren't quite what they used to be, it could be because they're owned by foreigners.The museums, aquariums and all things Ripley are owned by Vancouver billionaire, Jim Pattison.

He's been the area's most well known car dealer for decades but "The Jim Pattison Group" has grown to such huge dimensions that it would be almost impossible for somebody living here to not be directly affected by them on a daily basis.

If you go to www.jimpattison.com you'll see just how huge one businessman can become. It looks pretty "corporate" but the entertainment page (which primarily deals with Ripley's)is pretty slick looking.

Not mentioned in the site (but pretty well known around these parts) is thatto life in 2014 is a comfort unmatched in any other vacation spot. And your comments on Ober Gatlinburg were SPOT ON as well. It even SMELLS the same way it did when I first entered its hallowed Alpine hall in 1979. Well done, Sir!


state can also help. "Be forgiving of your mistakes," Dr. Khalafian says. "Attempt to see others' perspective in times of interpersonal discord, whether at home or at work. Live life to the best of your ability and according to your personal values."

Making the decision to seek help can be a very long and potentially painful one. Give yourself permission to ask for help. A consistent relationship with your primary care physician is a great avenue for starting the process of getting help.

The San Diego Warm Line, at
1-800-930-9276, is also available to lend a helpful ear, support and referrals to further professional assistance for callers who are not in crisis.

If you or someone you care about needs to speak to someone or is in crisis and needs immediate help,// ------------------------------------------------------------------------------
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// of this software and associated documentation files (the "Software"), to deal
// in the Software without restriction, including without limitation the rights
// to use, copy, modify, merge, publish, distribute, sub-license, and/or sell
// copies of the Software, and to permit persons to whom the Software is
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// IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
// FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO


or operating in six locations worldwide, Bombardier’s INNOVIA Monorail 300 system provides a cost-effective and attractive solution for growing cities. Project delivery, system integration and rail control solution design and implementation will be led from Bombardier’s regional hub in Bangkok. The INNOVIA trainsets will be manufactured at the Bombardier Joint-Venture Puzhen Bombardier Transportation Systems (PBTS) in China, working with Bombardier’s global Monorail Product and Engineering Experts. Since establishing its Bangkok site in 1997, Bombardier has grown its local team to over 450, working on transportation needs for Thailand, Asia Pacific and globally. Bombardier is also committed to the development of Thailand’s future talent and is working with two universities on Railway Engineering Degree programmes.in this study is accompanied by transfer of intracellular Zn^2+^ ions to extracellular apoSOD1, consistent with our interpretation above. Finally, and independent of the absolute quantification of ^65^Zn, the relatively lower ^65^Zn contents of the non-toxic mutants with decreased Zn^2+^ affinity support the conclusion that the cytotoxic action of apoSOD1 is linked to the uptake of Zn^2+^ ions.

![Intracellular Zn^2+^ is transferred to cytotoxic apoSOD1 proteins.\
Monomeric apoSOD1 \[C6/111A;F50E;G51E\] (**1**) and the mutants \[H46/48/120S\] (**2**), \[H71/80S;D83S\] (**3**) and \[H46/48/63/71/80/120S;D83S\] (**4**) were added to a final concentration of 10 µM to SH-SY5Y cells loaded with radioactive ^65^Zn. Samples of the culture media were collected, concentrated dry on a 10 K filter and exposed to a phospho-imaging screen. As reference for signal quantification, we used lysate of ^65^Zn-loaded cells and a standard


toxic to cultured cells [@pone.0036104-Adler1], [@pone.0036104-Hashemi1], [@pone.0036104-Shen1]. In the simplest case, chelation of Zn^2+^ is deleterious because several essential proteins depend critically on Zn^2+^ for their function. One example is coordination of Zn^2+^ to the active site of histone deacetylases, a class of enzymes that control DNA integrity and gene expression [@pone.0036104-Thiagalingam1]. Inhibitory binding of small organic molecules to the Zn^2+^ site of this protein has even emerged as a promising strategy in cancer therapy [@pone.0036104-Finnin1], [@pone.0036104-Marks1].

In striking resemblance with the observations in the present study, extracellular Zn^2+^ depletion is implicated in the toxic action of calprotectin, a Ca^2+^- and Zn^2+^-binding protein that reduces cell viability in a Zn^2+^-reversible manner [@pone.0036104-Yui1]. A distinct feature of the calprotectin toxicity is that it does not require direct cell contact: depleting{#s4}
=======

Protein expression and purification {#s4a}
-----------------------------------

To ensure good metal loading, SOD1 was co-expressed with the yeast Cu-chaperone CCS in E.Coli. The bacterial cultures were grown at 23°C, and CuSO~4~ (3 mM) and ZnSO~4~ (30 µM) were added upon induction. Purification was done by heat denaturation (55°C for 30 min) followed by ammonium sulfate precipitation, gel filtration (S100 Sephacryl 100, Amersham Pharmacia), and ion-exchange chromatography (Q-Sepharose) [@pone.0036104-Lindberg3]. The metal content for the monomeric holo protein was determined to 80% zinc and 20% copper (*data not shown*), using Total Reflection X-ray Fluorescence (TXRF).

Apo procedure {#s4b}
-------------

Apo protein was prepared by adding the protein solution to a Slide-a-Lyzer mini dialysis tube (Pierce) placed in a solution of 4 M of guanidinium chloride, 10 mM of MES buffer and 250 mM of EDTA for


Bruker 600 MHz spectrometer (Bruker Avance, Karlsruhe, Germany) equipped with a room temperature triple-resonance probe. All experiments were done at 25°C and pH 6.3 with 220--350 µM SOD1. In holo SOD1, Cu^2+^ was substituted with Zn^2+^. Spectra were transformed using nmrPipe and analyzed by Sparky (T. D. Goddard and D. G. Kneller, SPARKY 3, UCSF). In the T~1~ and T~2~ experiments the signal attenuation from 10 different relaxation delays was fitted to a single-exponential decay.

Normalization and fitting of cell viability data {#s4k}
------------------------------------------------

To have a measure of the total viability response of each mutant in [Figure 3A](#pone-0036104-g003){ref-type="fig"}, the area under each viability curve was calculated using Graphpad prism 5.0 and normalized against buffer and monomeric apoSOD1 within each individual experiment using the following expression: (area~mutant~-area~apoSOD1~)/(area~buffer~-area~apoSOD1~). In this way, bufferpresented as mean and range as percentage of buffer control. The metal concentration in the culture medium was varied between 40 µM (red), 20 µM (purple), 10 µM (green), 5 µM (orange) and 2.5 µM (blue). Addition of Zn^2+^ in equimolar concentration saves the cells almost completely, indicating that Zn^2+^ detoxifies apoSOD1 by filling the empty Zn^2+^ site. None of the other metals tested, i.e. Fe^2+^, Fe^3+^. Ni^2+^, Mn^2+^ or Cu^2+^, have this effect. Addition of an excess concentration of metal to a lower concentration of apoSOD1 do not increase toxicity indicating that these metals do not interact with the protein in such a way that harmful free radicals can be formed or other toxic pathways commence.

(TIF)

######

Click here for additional data file.

######

**Monomeric apoSOD1 induces toxicity also


not on the aesthetic appreciation of nature in general. This restriction of the scope of my claims matters a great deal. First, nature is a much more inclusive thing than a landscape. Nature includes animals, ecosystems, bacteria, microscopic structures of plants, galaxies, planets, etc. – all of which can be subject to aesthetic appreciation, but which cannot be said to be part of a landscape, at least not in normal cases where, for instance, the microscopic structure of a plant or a rock cannot be seen simply because it is too small to be perceived by an ordinary subject while she is appreciating a landscape (similarly for the rings of Saturn, too far to be seen in such viewing conditions, and so on). Second, while in this articlePerhaps, knowing how rare a sight the landscape illustrated by Figure 1 is – since it has to be observed at a very precise time after sunrise in conditions where there are no clouds and no wind at all, and at the right time of the year – can also augment its overall appeal. Many other types of information, coming from science, alpinism, or other sources can come into play. Thus, it seems that the 'simple' appreciation of landscapes is more subjective, while the 'informed' appreciation is more objective. But this does not mean that there is an opposition between the two – one being subjective and the other being objective. On the contrary, they usefully complete each other: the informed appreciation will (or at least, can) come


one learns something new about the landscape. Again, the Matterhorn is a good example. Standing in Zermatt at sunrise and observing this 9 incredibly pointy peak, one can feel thrilled by imagining what it must be like to stand on its top – how vertiginous this must be! But then, say that you actually climb up the Matterhorn, by the very route that can be seen from Zermatt (the Hörnli ridge), and you realize that most of the ascent is actually done by walking, and involves only relatively easy climbing parts, and that the summit is large enough for at least twenty people to sit there and have a picnic – a much less impressive and vertiginous experience than what one would have thought! You then realize thatof its own. When it comes to the way we talk about landscapes, not only the simple appreciation but the informed appreciation as well typically give rise to statements of aesthetic judgements. A landscape is often said to be beautiful, and even more so when information of the kind mentioned above is added. Also, and quite importantly, exactly as a simply appreciated landscape, a landscape appreciated in an informed and imagination-enriched way has the capacity to cause passion 11 and emotion – to borrow Hume's way to put it, such a landscape is fully "fitted to give a pleasure and satisfaction to the soul" (Hume (1975, p.299)). Fudge (2001, p.277, my italics) insists – rightly – on this point: "But why suppose that this [informed, science-based] appreciation is


do not (have to) exhaust the basis for an overall aesthetic experience. Similarly as in the case of works of art such as paintings, novels, or musical works, we have already seen above that the taste of the spectator and the origins (the creation) of a landscape (can) play a significant role in its aesthetic appreciation. Exactly as in the case of artworks, a quality evaluator is needed. For instance, one must be careful to use one's imagination in an appropriate way, for there is the risk that instead of enriching the appreciation of the landscape it can actually divert our attention from it – say, if I look at the Matterhorn, and this makes me imagine it as a Toblerone, which in turn makes me think ofin which the aesthetic properties are grounded). This is how the context of creation of landscapes and of photographs can be Figure 4. A Brocken spectre. 15 understood14. (Of course, some of these similarities can also, at least partly, concern other types of aesthetically appreciated objects, such as for instance paintings15.) Photographs, unlike other types of depictive entities (relevantly, unlike paintings), are always photographs of something existing (at the time of the creation of the photograph). Even a blurred, distorted, black-and-white photograph is always, in virtue of the nature of what a photograph is and how it comes into being, a photograph of something (something that reflects light recorded by the camera)16. Hallucinations set aside, a landscape, even understood as a perspectival observer-dependent relational entity, also always involves


and guided by the 'creator' of the landscape (by the kind of choices mentioned above, or by the information she provides). Aesthetic properties of a landscape are then grounded in this variety of non-aesthetic properties, where some of them are in the power of the creator of the landscape to influence, and there is then the same type of possibility of failure as in the case of artworks like photographs or paintings. Landscapes, in this sense, are like works of art – and very peculiar works of art indeed, since the artist always necessarily coincides with the spectator20. 19 Budd (2002, p.91): "[...] just as the aesthetic appreciation of art is the appreciation of art as art, so the aesthetic appreciation of nature is the aesthetic appreciation ofthis site and I expect the same from other users of this site.

I know that public chat is limited just to share the views of political issues, movies, sports and educational issues and I oath I never use unparliamentary, unlawful, abusive, vulgar words or phrases at any time.


coating that can be printed upon with ink. A water-borne urethane, commercially available from ICI Resins (or Zeneca Resins) Wilmington, Mass. under the trade designation xe2x80x9cNeorez R-960xe2x80x9d that has been combined with an aziridine cross-linker, also commercially available from ICI Resins, under the trade designation xe2x80x9cCX-100xe2x80x9d is a representative ink-receptive coating. This ink receptive coating is not stain resistance when contacted with highly plasticized polyvinyl chloride comprising fluorescent yellow dye.
In general, to enhance the durability and stain resistance of printed articles and articles, a protective cover film or top coat is often applied over the ink graphic. In order to contribute the desired properties, the protective cover film or top coat typically comprises a highly cross-linked polymer. An exemplary top coat is a polyurethane composition that is thetest method described in the examples passes the ink adhesion test with xe2x80x9c3M Scotchcal Screen Printing Ink Series 4400xe2x80x9d (black 4400-05). xe2x80x9cPassxe2x80x9d refers to less than 50% of the ink being present on the tape such that an ink graphic would be readable. Preferably, less than 10% of the ink is present on the tape and more preferably the tape is substantially free of ink.
xe2x80x9cEnhanced Surface Slipxe2x80x9d refers to the physical property wherein the coated surface of the article, prepared according to the test method described in the examples, will slide apart easily when overlapped onto itself by 4 inches (10 cm) with a four-pound (1800 g) weight on the overlap.
xe2x80x9cFlexiblexe2x80x9d refers to the physical property wherein a cured coating or film having a thickness of 50 microns


about 45 to about 80 percent by weight. Further, the cross-linking agent(s) is typically present in an amount ranging from about 5 percent by weight to about 35 percent by weight. Preferably, the concentration of cross-linking agent ranges from about 10 percent by weight to about 25 percent by weight. At concentrations greater that 35 percent by weight isocyanate cross-linker, the composition tends to become unprintable.
For embodiments wherein unreactive hard and soft components are alternatively employed, the concentration of the hard component(s) and soft component(s) is nearly the same as just described with the exception that the sum of the hard component(s) is typically at least about 15 percent by weight and the maximum amount of soft component is typically about 85 percent by weight. One of ordinaryskill in the art recognizes that the lack of cross-linker (e.g. polyisocyanate) renders the composition unreactive.
Polyurethanes may be synthesized from known techniques, by reacting one of more polyols with one or more isocyanates. Representative polyols include, for example, polyether polyols, polyester polyols, acrylic polyols, polyester amides, polycaprolactone polyols, etc. Polyether polyols, such as various polyoxyalkylene glycols, are prepared by the polymerization of alkylene oxides with suitable initiators having active hydrogens in their structure. Polyester polyols are generally prepared by reacting one or more dicarboxylic acids, also referred to as dimer acids, with one or more diols or triols. Common acids include adipic acid, glutaric acid, sebacic acid, suberic acid, azelaic acid, succinic acid, cyclohexane dicarboxylic acid, phthalic acid, as well as their corresponding anhydrides. Glycols typically employed in


the preparation of polyester polyols generally include ethylene glycol; 1,2-propylene glycol; 1,3-propanediol, 2-methyl-1,3-propanediol; 1,3-butanediol; 1,4-butylane diol; 1,6-hexanediol; diethylene glycol and neopentyl glycol. Polyisocyanates employed in the preparation of polyurethanes include diphenylmethane-4,4xe2x80x2-diisocyanate (MDI); toluene diisocyanate (TDI); 1,4-tetramethylene diisocyanate, 1,6-hexamethylene diisocyanate (HDI); 1,12-dodecane diisocyanate; cyclobutane-1,3-diisocyanate; 1-isocyanato-3,3,5-trimethyl-5-isocyanatomethylcyclohexan; bis(4-isocyanatocyclohexyl)methane; isophorone diisocyanate (IPDI); bis(4-isocyanatocyclohexyl)methane; 4,4xe2x80x2-methylene-dicyclohexyl diisocyanate; 1,6-diisocyanato-2,2,4,4-tetramethylhexane; 1,6-diisocyanato-2,4,4-trimethylhexane; cyclohexane-1,4-diisocyanate; as well as others.
For embodiments wherein a polymeric polyol is employed as the hard and/or soft component, the polymeric polyol is preferably a polyester polyol. A representative saturated polyester polyol suitable for use as the hard component is commercially available from Bayer Corporation, Pittsburg, Pa. under the trade designation xe2x80x9cDesmophen 651 A-65xe2x80x9d. Polymeric polyols suitable for use as the soft component are also available from Bayer Corporation under the trade designations xe2x80x9cDesmophen 670A-80xe2x80x9d andstain resistance. The article of the invention provides a significant cost savings in comparison to the same caliper of more expensive materials such as polyurethane film substrates and film substrate comprising fluoropolymers, alone or blended with other materials.
The articles of the invention may further comprise at least one bonding layer disposed on a surface of the inventive barrier layer composition. Although optional for solvent delivery of coatings and for the formation of extruded film substrates, the bonding of 100% solids systems typically prefers a bonding layer to adhere the inventive barrier layer to a substrate. The bonding layer is chosen such that it does not diminish the flexibility, printability and stain resistance of the composition of the invention, yet is sufficiently compatible such the bonding layer improves the


Liquid plasticizers and colorants soluble in the plasticizers tend to migrate over time in order to reach an equilibrium concentration at the interface between the film and a contacting layer or substrate. Internal migration or staining is evident by the presence of oil or stain on the exposed surface. Internal migration or staining can also be detected by the eventual staining of absorbent materials, such as paper, in contact with the exposed surface. Other external staining occurs when plasticized PVC is contacted with other soluble dyes contained in color layers, colored substrates, and fabric dye colorants found in laundered fabrics. In general, both internal and external staining tendencies worsen with increased temperature. The coatings and films of the present invention resist staining at ambient temperature. Preferred coating andPat. No. 4,025,159 (McGrath); U.S. Pat. No. 4,983,436 (Bailey); U.S. Pat. No. 5,064,272 (Bailey); U.S. Pat. No. 5,066,098 (Kult); U.S. Pat. No. 5,069,964 (Tolliver); and U.S. Pat. No. 5,262,225 (Wilson).
Cube corner sheeting, sometimes referred to as prismatic, microprismatic, triple mirror or total internal reflection sheetings, typically include a multitude of cube corner elements to retroreflect incident light. Cube corner retroreflectors typically include a sheet having a generally planar front surface and an array of cube corner elements protruding from the back surface. Cube corner reflecting elements include generally trihedral structures that have three approximately mutually perpendicular lateral faces meeting in a single cornerxe2x80x94a cube corner. In use, the retroreflector is arranged with the front surface disposed generally toward the anticipated location of intended observers and the light source.


happening right now," Mr. Brownfield said.

Some specialists have expressed skepticism about the approach. Bruce Bagley, a professor at the University of Miami who focuses on Latin America and counternarcotics, said that what had happened in West Africa over the past few years was the latest example of the "Whac-A-Mole" problem, in which making trafficking more difficult in one place simply shifts it to another.Q:

Triggering infinite loop in ember routing mechanism

http://jsfiddle.net/pauldechov/EJQ8v/
Click to the post, and then to comments. Am I doing something wrong? This type of case shows up multiple times in my app, and I'm not sure how to have it arrive at this route successfully.
Edit: https://github.com/emberjs/ember.js/issues/1231 this issue & fix doesn't seem related, but perhaps it is?

A:

This seems to work just fine
Overall your routing seems really complicated to me and possibly doing things wrong. Maybe you're trying to do something more complex and my simplification of it has wrecked it?
    posts: Em.Route.extend({
        route: '/posts',
        gotoPost: Em.Route.transitionTo('post'),

        connectOutlets: function(router) {


best traction in specific conditions.

The transmission is equipped with a slipper clutch on the spur gear. With a high-performance model, a clutch will help you prevent wheel spin. In this application, the biggest benefit of a clutch is that it helps protect the gears from shock loads when landing from jumps and sudden transitions from forward to reverse. It probably isn't a necessary item, but it should improve the Amp's longevity. Like the ball bearings, the clutch is an unexpected, but appreciated bonus feature on this budget truck.

Chassis Cons

All of the suspension linkages and steering rods are fixed-length, preventing any adjustment of the suspension geometry.

My only gripe with the chassis setup of the Amp is that none of the suspension linkages are adjustable. The steering rods and uppersuspension linkages are all fixed-length nylon parts. In one sense, that can be seen as a good thing. With no adjustment options, there is no way for a hapless beginner to foul things up.

Beginner-oriented trucks like the Amp are great hands-on science classrooms.

On the other hand, I've always thought that RC cars are a great tool for kids (and adults) to learn science. Making adjustments to camber and toe-in (one change at a time, of course), and then seeing the performance differences, can be a great hands-on lesson in physics. It would be nice if the Amp included adjustable linkages and a few mounting options to accommodate that spectrum of the beginner's learning curve. On the plus side, upgrading the linkages with adjustable aftermarket parts is a simple


you to set how much steering and throttle the truck has. As I found with my daughter, scaling back both controls is a big help for new drivers. The transmitter is physically much smaller than most modern radios, but it is a comfortable grip for me. My 8-year-old did not have any ergonomic problems either.

Electronics Cons

The receiver end of the radio system is actually a combination receiver and Electronic Speed Control (ESC). This isn't necessarily a bad thing. It merely means that both components must be replaced if one of them goes bad or you want to upgrade. My only real issue with the unit is the lack of any published specifications for the ESC side. It would be great to know what built-in features the ESC has.modify the Amp into a competitive club-level racer if you really wanted. But it may not make economic sense to do so. I think the Amp is best viewed as a tough, hobby-grade basher to help you learn the ropes of RC cars. With that in mind, we should repeat the initial question, "What do I sacrifice by selecting a bottom-dollar RC truck?" I think the answer is, "Not much."

Terry is a freelance writer living in Lubbock, Texas. Visit his website at TerryDunn.org and follow him on Twitter and Facebook. You can also hear Terry talk about RC hobbies as one of the hosts of the RC Roundtable podcast.


and the incision closed with sutures. A corticosteroid anti-inflammatory (dexamethasone; 1 mg/kg, i.m.) was given immediately after surgery to control edema, and analgesics (buprenorphine 0.005--0.01 mg/kg, i.m.) were routinely administered for a minimum of 24 h after surgery, and then provided daily as needed. The antibiotic cefazolin (20--30 mg/kg, i.m.) was given after surgery and continued as needed. Saline (50--200 ml, s.q. or i.v.) was provided to compensate for fluid loss. After the return of sternal recumbence and active locomotion, the animal was returned to its home cage.

Following surgery, each animal exhibited the characteristic tonic head deviation toward the lesion side and ipsiversive circling behavior that is associated with these lesions (Sprague, [@B59]; Sherman, [@B54]; Jiang et al., [@B22]). These symptoms resolved within 1 or 2 days. However,tests. Logistic regression was used to determine whether any significant differences in visual recovery were related to the different multisensory training conditions. This was accomplished by comparing regression models fit to data pooled across all animals (using nearest-neighbor interpolation to fill gaps) to models in which a single animal was extracted and fit separately from the pool. This allowed each animal's performance to be compared to the pooled data. The difference in deviances between the two models was evaluated against an *X*^2^ distribution with 1 degree of freedom. The significance of physiological responses was evaluated with two-tailed *t*-tests.

Histological Evaluation of Cortical Lesions {#s2-8}
-------------------------------------------

At the termination of experimentation each animal was sedated with ketamine hydrochloride (20--30 mg/kg, i.m.) and acepromazine maleate (0.05--0.1 mg/kg i.m.) and, following the loss of


2,400 exposures/session). Visually-responsive neurons were readily found in each of these animals (no inter-animal differences were observed, see exemplars in [Figure 7A](#F7){ref-type="fig"}), and their pooled modality convergence patterns are shown in the left plot of [Figure 7B](#F7){ref-type="fig"}. Many (74%, 58/78) of the visual receptive fields recorded in rehabilitated animals were very large and extended into central visual space. An overwhelming majority of these neurons were also overtly responsive to auditory inputs. The incidence of visually-responsive neurons also sensitive to the auditory modality (70%, 26/37) was roughly twice that expected given their incidence in the normal SC and in recordings from the contralesional SC of hemianopic animals (Meredith and Stein, [@B36]; Jiang et al., [@B22]). Given the high incidence (\>30%) of "covert" multisensory neurons (one of the inputs islikely produces significant and permanent functional consequences that were not explored here. Physiological changes in SC neurons have been noted with visual cortex lesions of varying extent and these include limiting the capabilities of SC neurons to respond selectively to direction or velocity of movement, and lowering the incidence of binocularity (e.g., see McIlwain and Fields, [@B33]; Rosenquist and Palmer, [@B48]; Ogasawara et al., [@B40]; Hardy and Stein, [@B17]). Perceptually, it is likely that the lesion compromises higher-order visual functions such as those related to the identity or meaning of visual events.

Also important to note is that a region of ipsilateral association cortex (the AES) distant from the lesion site appears to play a crucial role in supporting the restored SC visual activity. Removing AES after training-induced recovery


little knowledge of very basic and fundamental content. It truly does frighten me to think that so many professors are using technology to distance themselves from this knowledge. Better to turn off the lights and cue up the power points; divide them in groups and give the "innovative projects" to work collaboratively on; or better yet build a wiki with no knowledge of what is and is not valid Internet source material: these all examples of activities I have witnessed first-hand.

No easy answers here. It just takes hard work and the desire to connect. Soon, we will be going with the flow and life will get easier. Then I will be able to look outward, again.

Update: Now see, this is the sort of thing I am talking about.rectal cancer who were diagnosed with clinical stage T3 or T4 and/or node-positive disease.^\[[@R9]\]^ The choice of laparoscopic surgery was determined by an informed consultation between the surgeon and patient. All surgeries were performed by 2 experienced colorectal surgeons.^\[[@R10],[@R11]\]^ After a standardized preoperative preparation, a complete mesocolic excision and central vascular ligation were performed for patients with colon cancer.^\[[@R12]\]^ In patients with rectal cancer, a high ligation of the inferior mesenteric artery and total mesorectal excision were performed.^\[[@R13]\]^ After the pathology report was completed, all patients with stage II, III, and IV disease were advised to undergo chemotherapy according to the National Comprehensive Cancer Network (NCCN) guidelines.^\[[@R14],[@R15]\]^

2.4. Outcome variables
----------------------

All data were analyzed according to the intention-to-treat principle. Postoperative surgical complications were defined as the events that required additional


and without postoperative complications, respectively (Fig. [2](#F2){ref-type="fig"}).

![Association between the occurrence of postoperative complications and total hospital charges during the index surgery. Increased mean total hospital charges are associated with the occurrence of postoperative complications (*P* \< .001) and more severe complications (Clavien--Dindo score ≥3, *P* \< .001).](medi-97-e0653-g006){#F2}

3.7. Association between the ASA score and total hospital charges during the index surgery
------------------------------------------------------------------------------------------

A higher ASA score is associated with an increased amount of mean total hospital charges (*P* = .002). Mean total hospital charges were 10,769 USD, 11,756 USD, and 13,906 USD in the ASA score 1, 2, and 3 groups, respectively (Fig. [3](#F3){ref-type="fig"}).

![Association between the American Society of Anesthesiologists scores and total hospital charges during the index surgery. A higher American Society of Anesthesiologists score is associated with higher mean total hospital charges (*P* = .002).](medi-97-e0653-g007){#F3}

4. Discussion
=============

The majorpromoted to a higher grade prior to April 2013 may be eligible for a revised promotion salary (promotion recalculation) provided the employee is not eligible for a performance advance in the higher grade in April 2013.

Ineligible for Performance Advance

Employees with an “Unsatisfactory” evaluation on their last rating date are ineligible to receive an April 2013 Performance Advance. The agency must submit a Data Chg on the Job Action Requests page using the Reason code USP (Unsat Perf) and an increment code of 7777 in the Incr. Code field to withhold the performance advance. The effective date should be the employee’s last rating date. These transactions should be submitted as soon as practicable following the employee’s rating date.

In addition, employees new to a Security bargaining unit who have not


the proper increment code for April 2013 in the Incr. Code field.

For pay changes, position changes and transfers requested on the Job Action Requests or Transfer Requests page with an effective date after 03/28/13 (Administration) or 04/04/13 (Institution):

The agency must include, if applicable, the performance advance in the salary rate reported in the Pay Rate field.

The agency must report the projected increment code based on the employee’s next performance advance cycle in the Incr. Code field.

Time Entry

To report miscellaneous earnings that are automatically calculated by the system (e.g. overtime), agencies must separate earnings by pay period so the earnings will not overlap the effective date of the Pay Change transaction.

In addition, agencies must manually update the Pre-Shift Briefing amount paid to employees in BU61, BU91 or BU31 usingis represented by a fraction, the numerator of which is the time the parties were married, the denominator is the total time worked before full retirement benefits may be received.
Fondi v. Fondi, 106 Nev. 856, 859, 802 P.2d 1264, 1265-66 (1990) (citations omitted).
[4]  This phrase was coined during this court's decision in Fondi.
[5]  In Gemma, we also concluded that if the pension holding spouse was worried that his or her high income after marriage may be a "reflection of increased effort and achievement, he or she can request that the court retain jurisdiction in the event such predictions become reality." Gemma, 105 Nev. at 463, 778 P.2d at 432.
[6]  In the event Mona's employment ceases prior to attaining the projected highest salary, retention of jurisdiction


  The Court amends its opinion filed January 22, 1998, as

follows:
           On page 25, footnote 14, line 2 -- the citation to Barnes

v. Thompson is corrected to read "58 F.3d 971, 974 n.2."

                                       For the Court - By Direction

                                        Attorney
General, Robert F. Daley, Jr., Assistant Attorney General, Columbia,
South Carolina, for Appellants. Vance L. Cowden, William Lewis
Burke, Jr., Department of Clinical Legal Studies, UNIVERSITY OF
SOUTH CAROLINA SCHOOL OF LAW, Columbia, South Caro-
lina, for Appellee Gilbert; David P. Voisin, Hilary Sheard, CENTER
FOR CAPITAL LITIGATION, Columbia, South Carolina, for Appel-
lee Gleaton.

_________________________________________________________________

OPINION

WILKINS, Circuit Judge:

Half brothers Larry Gilbert and J. D. Gleaton (collectively, "Peti-
tioners") filed petitions for habeas corpus relief1 from their South Car-
_________________________________________________________________

1 Petitioners named James Aiken, Warden of Central Correctional Insti-
tution where they were then incarcerated, and the South Carolina Attor-
ney General as Respondents in their petitions. Subsequently, Michael W.
Moore, Director of the South Carolina Department of Corrections, was
substituted for Aiken. For ease of reference, we refer to Respondents col-
lectively as "the State" throughout this opinion.


                   5
proceedings and to waive exhaustion as to the remaining issues pend-
ing in state court.

On August 26, 1996, the district court held that Petitioners were
entitled to habeas relief.3 The court ruled that the challenged jury
charge constituted a mandatory presumption that shifted the burden
of proof on the issue of malice from the prosecution to Petitioners in
violation of the Fourteenth Amendment and that the error was not
harmless. The court determined, however, that the remaining grounds
for relief pressed by Petitioners lacked merit.

II.

Petitioners' principal claim is that an instruction to the jurors dur-
ing the guilt phase of their capital trial shifted the burden of proof on
the element of malice from the prosecution to themState to them on this issue. See Yates, 500 U.S. at 400-
02; Francis v. Franklin, 471 U.S. 307, 315-18 (1985); Sandstrom v.
Montana, 442 U.S. 510, 524 (1979). The State concedes that the pre-
sumed malice instruction amounted to an error of constitutional mag-
nitude. And, although we are not bound by the State's concession, see
Sibron v. New York, 392 U.S. 40, 58 (1968), we agree that the chal-
lenged instruction constituted an unconstitutional burden-shifting
instruction, see Hyman v. Aiken, 824 F.2d 1405, 1409 (4th Cir. 1987).
The dispositive issue with respect to this claim, then, is whether the
error occasioned by the unconstitutional instruction was harmless.

It is now well established that not all errors of constitutional
dimension warrant a federal court to overturn a state conviction or
sentence. See Chapman v. California, 386 U.S. 18, 23-24


he and Gilbert decided to rob the victim after
passing the store in their automobile and noticing that Stoudemire was
alone:

        I went in and asked the man how much his cigarettes were
        and he told me and I said I could get them cheaper some-
        where else. [Gilbert] came in the door so we could rob the
        man. We decided to rob the man after we had passed by and
        saw he was by himself. I was fixing to pay the man for the
        cigarettes when [Gilbert]1502-03 (11th Cir. 1985)
(en banc) (holding burden-shifting instruction harmless because sin-
gle crushing blow delivered to victim's skull was not the type that
happens by chance). Furthermore, because they were engaged in an
armed robbery, neither Gilbert nor Gleaton possessed any legal justi-
fication for an intentional attack on Stoudemire. See State v. Brown,
467 S.E.2d 922, 924 (S.C. 1996) (per curiam) (holding that "[u]nder
the law of self-defense, one who is attacked on his own premises is
immune from the duty to retreat," but "a lawful guest has a duty to
retreat when attacked by the owner"); see also State v. Ivey, 481
S.E.2d 125, 127 (S.C. 1997) (noting that "[t]he exercise of a legal
right ... is never in law deemed a provocation sufficient to justify or
mitigate an act of violence"). Considering the totality of the


denial
of PCR. Gleaton attempted again to raise the issue in his second PCR
proceeding, but that court held that the issue was successive. Gleaton did
not raise the issue in his petition for certiorari to the South Carolina
Supreme Court.

                     28
the majority opinion. I would decide the issues raised in part VI on
the merits in favor of the State.

DIANA GRIBBON MOTZ, concurring in parts I through V, part VII,
and the judgment:

I originally joined the panel opinion affirming the district court's
grant of writs of habeas corpus to Larry Gilbert and J. D. Gleaton. On
further study, I have determined that I must vote to reverse. The anal-
ysis and authorities Judge Wilkins has marshalledof intention." See Public Finance Corp. v. Freeman, 712 F.2d 219 (5th Cir.1983); Barnes v. Whelan, 689 F.2d 193 (D.C. Cir.1982).
The sixth circuit has not prescribed a list of good faith attributes. At least 16 factors have been considered by other circuits. Many of the stated components of "good faith" are duplicative of specific standards for confirmation applied elsewhere in the Bankruptcy Code. Some factors adopted in early decisions are affected by subsequent amendments to the Bankruptcy Code.

A. FREQUENCY OF FILING BANKRUPTCY
Multiple and successive bankruptcy filings by the same debtor are a problem in some judicial districts. See, e.g., In re Kinney, 51 B.R. 840 (Bankr. C.D.Cal.1985) (10 filings including multiple Chapter 13 cases by related family members); Snow v. Jones (In re Jones), 41 B.R. 263 (Bankr.


(1982 ed. & Supp. III 1986). This right cannot be waived. This right can be exercised after a judgment of nondischargeability in the Chapter 7 case.
*952 Some decisions conclude that conversion to Chapter 13 after losing a discharge or dischargeability battle in Chapter 7 is relevant to good faith but not conclusive of bad faith. See Ravenot v. Rimgale (In re Rimgale), 669 F.2d 426, 431-32 (7th Cir. 1982) (good faith cannot be defined as "the absence of any conduct that would traditionally have barred discharge, without rendering Chapter 13's discharge provisions nugatory."); Street v. Lawson (In re Street), 55 B.R. 763, 765 (Bankr. 9th Cir. 1985) ("A conversion from Chapter 7 to Chapter 13 following an adverse decision on a dischargeability action is not a `manipulation ofthe Bankruptcy Code.'"); In re Caldwell, 67 B.R. 296, 303 (Bankr.E.D. Tenn.1986) (plan was not proposed in bad faith simply because it proposes to deal with nondischargeable debts from preconversion Chapter 7); In re Parameswaran, 64 B.R. 341 (Bankr.S.D.N.Y.1986) (conversion from Chapter 7 to Chapter 13 permitted notwithstanding successful objection to discharge in Chapter 7 case); In re McMonagle, 30 B.R. 899, 10 BANKR. CT. DEC. (CRR) 1086 (Bankr.D.S.D.1983) (confirms plan comprising debt declared nondischargeable in Chapter 7 case converted to Chapter 13); In re Martini, 28 B.R. 932 (Bankr. S.D.N.Y.1983) (not bad faith to pay less than 100% of loan declared nondischargeable in prior liquidation case);.
Many courts have confirmed Chapter 13 plans over good faith objections notwithstanding composition of claims that would be nondischargeable in a Chapter


depend on the individual momenta ${k}_{i}$, $k_j$ and ${k}_{k}$, but only on ${K}_{I},{K}_{K}$. This function ensures that any partonic contribution give rise to an $m$-jet final state.

The phase space $\d \Phi_{m+1}$ can be factorised as follows, $$\begin{aligned}
\label{eq:psx3}
\lefteqn{\d \Phi_{m+1}(k_{1},\ldots,k_{m+1};q)  = }
\nonumber \\ &&
\d \Phi_{m}(k_{1},\ldots,{K}_{I},{K}_{K},\ldots,k_{m+1};q)
\cdot
\d \Phi_{X_{ijk}} (k_i,k_j,k_k;{K}_{I}+{K}_{K})\;.\end{aligned}$$ For massive radiators, the phase space ${\rm d}\Phi_{m}$ is the $d$-dimensional ($d=4-2{\epsilon}$) phase space for $m$ outgoing particles with momenta $p_{1},\cdots ,p_{m}$, masses $m_{1}, \cdots, m_{m}$ with total four-momentum $q^{\mu}$. It reads, $$\label{eq:phi}
\d \Phi_m(k_{1},\ldots,k_{m};q)
= \frac{\d^{d-1} k_1}{2E_1 (2\pi)^{d-1}}\; \ldots \;
\frac{\d^{d-1} k_m}{2E_m (2\pi)^{d-1}}\; (2\pi)^{d} \;
\delta^d (q - k_1 - \ldots - k_m) \,,$$ with $$E_{i}=\sqrt{|\vec{p}_{i}|^2 +m_{i}^2}.$$ $S_{m}$ is a symmetry factor for identical partons in the final state. $d\Phi_{X_{ijk}}$ is the NLO antenna phase space, it is proportional to the three-particle phase$$\begin{aligned}
X_{ijk}^0 = S_{ijk,IK}\, \frac{|{\cal M}^0_{ijk}|^2}{|{\cal M}^0_{IK}|^2}\;,\end{aligned}$$ where $S$ denotes the symmetry factor associated to the antenna, which accounts both for potential identical particle symmetries and for the presence of more than one antenna in the basic two-parton process. The massive antenna functions will be given below in Section 3 while their unresolved limits will be presented in Section 4.

Massive NLO antenna functions
=============================

The massive final-final antenna functions can be derived from physical matrix elements of the same processes as in the massless case [@antenna; @gluino; @higgs] but considering the final state radiators to be massive. More precisely, the quark-antiquark antenna function which we denote by ${\ensuremath{A^{0}_{Qg\bar{Q}}}}$ (to be distinguished from $A^{0}_{qg\bar{q}}$) can be derived from $\gamma^{*} \to Q \bar{Q}+g$ with $Q$ being a massive quark of mass $m_{Q}$, $g$


is a massless gluon. We find three types of massive quark-gluon antennae involving either one or two massive partons. Those can be derived from the following processes: ($\tilde{\chi} \to \tilde{g} +$ 2 partons). For these final state partons being two gluons, we derive $D^{0}_{Qgg}$ while for these partons being a quark-antiquark pair, we derive ${\ensuremath{E^{0}_{Qq'\bar{q}'}}}$ and ${\ensuremath{E^{0}_{qQ'\bar{Q}'}}}$. Lastly, we can also define a massive gluon-gluon antenna through the process $H  \to g Q\bar{Q}$, with one of the gluons in the final state emitting a massive $Q \bar{Q}$ pair. All new massive antenna functions are given below with $m_{Q}$ denoting the mass of the massive quark $Q$, $g$ is a massless gluon and the invariant $s_{ij}$ is chosen to be $s_{ij}=2\, p_i\cdot p_j$ making the mass dependence inthe unresolved and massless parton emitted between those can be either collinear or soft. In these corresponding unresolved limits, defined as in [@antenna] the $(m+1)$-parton matrix element squared factorises into a reduced $m$-parton matrix element and the well known soft eikonal factor when a gluon is soft and one of the three different Altarelli-Parisi splitting functions [@AP] when two of the three massless partons are collinear. When the radiators which emit a massless and unresolved parton between them are massive instead, the limiting behaviour of the matrix elements has to be changed and the unresolved factors have to be modified accordingly. In this section we first recall the single unresolved massless factors and present their extension needed to deal with massive radiators. Finally, we list all non-vanishing limits


   &\int d s_{ij}\, ds_{jk}\,ds_{ik}\, \delta( {E_{cm}}^2-m_i^2-m_j^2-
m_k^2-s_{ij}-s_{jk}-s_{ik})\\
    &[4\,\Delta_3(p_{i},p_{j},p_{k})]^\frac{d-4}{2} \;
\theta(\Delta_3(p_{i},p_{j},p_{k})).
\end{split}$$ The masses $m_{I}$ and $m_{K}$ appearing in this equation are combinations of the masses $m_{i},m_{j}$ and $m_{k}$ and the integral over $\Omega_{d-2}$ has been performed. The function $\Delta_3(p_{i},p_{j},p_{k})$ is the Gram determinant for massive particles of momenta $p_{i},p_{j},p_{k}$ given in terms of invariants $s_{ij}=2p_i \cdot p_j$ and masses $m_{i},m_{j},m_{k}$ by, $$\Delta_3(p_{i},p_{j},p_{k}) =
\frac{1}{4}\left(s_{ij}s_{ik}s_{jk} - m_i^2 s_{jk}^2-m_k^2s_{ij}^2
-m_j^2 s_{ik}^2 + 4 m_i^2 m_j^2 m_k^2 \right)$$

As in the massless case, the factorisation of the phase space is exact. The expression for the antenna phase space $d\Phi_{X_{ijk}}$ given in eq. (\[eq:phix\]) can also be found in [@cdst1; @weinzierl], where it was called a dipole phase space. At NLO, both massless and massive dipole and antenna phase spacesterms of hypergeometric functions we could show that, $${\ensuremath{\Gamma^{had}_{\gamma^*, \text{real}}}}+ {\ensuremath{\Gamma^{had}_{\gamma^*, {vertex}}}}= \Gamma^{had}_{{\gamma^*}}$$ giving us a strong check of our integrated massive final-final $Q\bar{Q}$ antenna ${\ensuremath{{\mathcal{A}}^{0}_{Qg\bar{Q}}}}$.

Conclusions and Outlook
=======================

We have generalized the antenna subtraction method, originally developed for massless final states to real radiation off massive final state partons at the next-to-leading order level. The main building blocks of the antenna subtraction method are the antenna functions. Those encapsulate all unresolved radiation emitted between two colour-ordered hard radiators. As such those functions account for all unresolved radiation of the corresponding QCD matrix elements. In Section 3, we have presented the final-final antenna functions for the following cases: the presence of two massive final state radiators of equal masses or the presence of one massive and one massless radiator. Section


[**0803**]{} (2008) 030 \[arXiv:0801.1917\]; arXiv:0901.3587. S. Frixione, P. Nason and C. Oleari, JHEP [**0711**]{} (2007) 070 \[arXiv:0709.2092\].

M. Dinsdale, M. Ternick and S. Weinzierl, Phys. Rev.  D [**76**]{} (2007) 094003 \[arXiv:0709.1026\]. S. Schumann and F. Krauss, JHEP [**0803**]{} (2008) 038 \[arXiv:0709.1027\];\
S. Höche, F. Krauss, S. Schumann and F. Siegert, \[arXiv:0903.1219\].

T. Gleisberg, S. Höche, F. Krauss, A. Schalicke, S. Schumann and J. C. Winter, JHEP [**0402**]{} (2004) 056 \[hep-ph/0311263\];\
T. Gleisberg, S. Höche, F. Krauss, M. Schönherr, S. Schumann, F. Siegert and J. Winter, JHEP [**0902**]{} (2009) 007 \[arXiv:0811.4622\].

G. Altarelli and G. Parisi, Nucl. Phys.  B [**126**]{} (1977) 298. K.G. Chetyrkin and F.V. Tkachov, Nucl. Phys. B [**192**]{} (1981) 159.

F.V. Tkachov, Phys. Lett. B [**100**]{} (1981) 65;\
C. Anastasiou and K. Melnikov, Nucl. Phys.  B [**646**]{} (2002) 220 \[hep-ph/0207004\]. A. Gehrmann-De Ridder, T. Gehrmann and G. Heinrich, Nucl. Phys. B [**682**]{} (2004) 265 \[hep-ph/0311276\]. S. Laporta, Int. J. Mod. Phys. A [**15**]{} (2000) 5087 \[hep-ph/0102033\].

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T. Gehrmann and


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                $("#" + this._id + "_dialogEdit").ejDialog({ title: "Edit Record" });
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            Integration Site Family Member 5A in Lhcgr KO Mice {#sec2.4}
---------------------------------------------------------------------------------------------

Because GDNF protein levels did not change in *Lhcgr* KO mice, we considered it likely that other genes are involved in enhanced SSC self-renewal. To explore this possibility, we used busulfan-treated *Lhcgr* KO and control WT mice and examined their gene-expression patterns using microarray analysis. Comparison between *Lhcgr* KO and control mice showed increased expression of 101 genes in *Lhcgr* KO mice, while 385 genes were downregulated (\>2-fold change) ([Table S1](#mmc1){ref-type="supplementary-material"}). Of these, we searched for cytokines or secreted molecules implicated in cell proliferation and identified several candidate molecules, including wingless-type MMTV integration site family member 5A (*Wnt5a*), delta-like 1 homolog (*Dlk1*), secreted frizzled-related protein 1 (*Sfrp1*), and secreted frizzled-related protein 4 (*Sfrp4*), which were upregulated in *Lhcgr* KO


The numbers of colonies generated by *Wnt5a*-transfected and control donor cells were 2.2 ± 0.4 and 1.0 ± 0.3 per 10^5^ cells, respectively (n = 18 for *Wnt5a*-treated; n = 19 for control) ([Figures 6](#fig6){ref-type="fig"}G and 6H) (p = 0.009), suggesting that *Wnt5a* has a beneficial effect on SSC self-renewal in vivo. Taken together, these results suggest that LH suppresses SSC self-renewal by downregulating *Wnt5a* via androgens ([Figure 6](#fig6){ref-type="fig"}I).

Discussion {#sec3}
==========

Regulation of SSC self-renewal by gonadotropic hormones has been suggested since the early days of spermatogonial transplantation experiments. Several studies based on GnRH analog administration have demonstrated the involvement of the gonadotropic pituitary hormone in SSC regulation ([@bib8], [@bib26]), which was confirmed by another study using hypophysectomized animals ([@bib11]). However, the mechanism underlying this phenomenon has remained unclear. Moreover, controversy exists regarding the regulationLH.

Our studies strongly suggest that *Wnt5a* upregulation is responsible for increased SSC activity in *Lhcgr* KO mice. The beneficial effects of *Wnt5a* were reported in a recent study ([@bib32]) in which *Wnt5a* increased the survival of SSCs in vitro. Although this study suggested that suppression of apoptosis is the primary role of *Wnt5a*, a net increase in the SSC number by *Wnt5a* was not demonstrated. Moreover, *Wnt5a* expression was examined only by measuring *Wnt5a* mRNA levels via in situ hybridization, and the role of *Wnt5a* in vivo remains unclear. In contrast, we showed that *Wnt5a* increases the number of SSCs both in vitro and in vivo. Because the effect of *Wnt5a* OE on SSC increase was modest compared with *Lhcgr* KO mice, it remains possible that other factors are involved. While we cannot


exclude the possibility that WNT5A may not have been overexpressed in all cells, these results strongly suggest that *Wnt5a* is responsible, at least in part, for enhanced SSC self-renewal in *Lhcgr* KO mice. Because WNT5A is expressed more strongly in pup testes, it may be one of the factors that contribute to the rapid increase in SSC numbers during perinatal testis development ([@bib27]). In fact, the plasma concentration of LH in prepubertal mice is relatively low until 7--8 days of age ([@bib22]), which may induce WNT5A expression. The lack of LH appears to partially induce an immature phenotype in Sertoli cells because AMH immunoreactivity also increased in mature *Lhcgr* KO mice. Therefore, LH is not only required for Leydig cell maturation but is also important for suppressing the immature phenotypeof GDNF expression and understanding how they are coordinated GDNF expression are urgent problems in understanding niche function. Second, it is important to identify the signal that enhances SSC colonization in GnRH-treated recipients or hypophysectomized animals. Although increases in colony numbers were observed in GnRH-treated and hypophysectomized mice, respectively ([@bib8], [@bib11], [@bib26]), we did not observe an apparent increase in the number of colonies in *Lhcgr* KO recipients. Therefore, pituitary signals other than LH are likely responsible for the enhanced colonization of donor cells. In this context it should be noted here that, although GnRH antagonist treatment before the transplantation improved colonization, the same treatment did not enhance colonization when GnRH was administered at the time of transplantation ([@bib8]). It is believed that the major effect of GnRH


the salesman that call at dinnertime or the surveys that ring at seven o'clock in the morning. Which you never answer because you know it's not anybody important. We'd be sharing THAT status. It's not the worst choice necessarily, but when we call someone who has anonymous call rejection (my parents, for one), we will not be able to get through. At all. Ever. Our current company doesn't have a fancy star-number-number we can dial to be able to get through (I asked). Our calls are eternally blocked to these numbers.

The third option is to do nothing. I can leave it as-is, and accept that I am Durga Kameneini when I call people. I can almost always guarantee that every time I make a phone call I'll get(I can’t quite make it out on the google maps view. It does seem to be a very small house for having been a boarding house and shop!

Oops, yes thank you for pointing that out! Serves me right for ranting. I’ll take a photo of it soon then. It is amazing how many people you can cram into these tiny houses (the students are still at it today!).


Q:

Why are generic flags not available for low score answers?

I've just tried to flag a low score answer as "Not an answer" and the only option available was "Needs ♦ moderator attention".

Why are generic flags not available for low-quality answers?
What's the appropriate action in this case? Should I flag for moderator attention or are low score answers automatically flagged by the system?

(the answer has already been taken care of as I'm typing this question)

A:

This happens if you click the "flag" button on a deleted post when you don't have enough reputation to see deleted posts, but you still see it because your browser loaded the page before the post was deleted, and you haven't refreshed the page to reflect the recent deletion. In other words, it's almost like[2+2] metallomacrocycles. At higher pH levels (pH = 4-6), the three-dimensional polymers [M(Hpdc)(H(2)O)] (Ca 3, Sr 5, Ba 7 ) were isolated by reactions of MCl(2) (M = Ca, Sr, Ba) with H(3)pdc in water/Et(3)N or in M(OH)(2) (M = Ca, Sr, Ba) with H(3)pdc in water under hydro(solvo)thermal conditions (150 degrees C, 3 days). Calcium and strontium are seven- and nine-coordinated in 3 and 5, respectively; barium is nine- and ten-coordinated in 7. It was observed that the increase in pH resulted in a higher connectivity level of ligands, which in turn leads to a higher dimensionality of the crystal structures. The correlation between the structures and pH values will be discussed. Crystal data: for 1, monoclinic, space group P2(1)/n (No. 14), with a = 8.382(2), b


amendment of Ordinance No. 294 to cause the rezoning as requested by the petitioner."
 It is clear that this in nowise complies with section 65653. No "copy of any precise plan, regulation or amendment recommended ..." is submitted. It may be that the letter constitutes "findings" of the recommendation of the commission, but it definitely does not contain any "summaries of hearings." The commission's proceedings of April 11 comply neither with the letter nor the spirit of the Government Code requirements for amending a zoning ordinance. Section 65654 is the one giving the council authority to act. It provides: "Upon receipt of a copy of any proposed precise plan or regulation based upon a master or general plan or amendment of such plan or regulation," (emphasis added) thethat stupid name. Like bad Hollywood, Golden Era ignorance that was endearing but also clearly pretty racist are we not gonna talk about this?

“What The Jazz Singer did for international cinema is pretty obvious,” I once tried in a film lecture. “But are we not going to touch upon how fucked up that blackface was? They were also Jewish and stereotyped pretty bad. Anybody? Back me up here.”

Command shift 4

My professor was not amused. I think he was the department head. I think he was also Jewish.

“See me after class.”

“Bueller?”

I scraped by with a B-.

So it didn’t help that Lalí brought all that bad juju to mind. It only got worse from there. After letting my thoughts go that route, Carlos still talking his head off (“Lalí likes


all latinas master at a young age in defiance of their matriarchs. These dark eyes—cómo parecen puto—how serious they look to you?

“Babe, it’s just Oreos.”

“Don’t you babe me,” she said with a flick of her manicured hand, as though to slap the word away. “There’s so many chemicals y mierda in those. You couldn’t be eating anything worse for you.”

We glanced down at the Oreos in our palms, their black cookies resting innocently enough.

“¿De verdad?”

“I promise you,” she said.

“For real, for real?” I asked, eyebrow raised, forever the skeptic.

“Promise.”

“Daaaaaaaaaamn,” Carlos and I said in unison, dropping our Oreos to the coffee table, where they landed with a satisfying thump. Only then did I notice the episode of South Park we had running on the TV.

“Bro she’s ruined Oreosgoing on and on and on and on about him. To the point where I missed something important she had said, distracted this time not by her stud but the swelling above her right eye. Its shades of purple and red were not unlike the ones found on a fresh heart for Huitzilopochtli, wet with blood and still beating on his tongue.

Jenzo DuQue is a Colombian-American writer from Chicago. He once spent four weeks alone in a rustic cabin, where he found himself, lost himself, and then found himself again. In the Fall he will pursue his Master's at Brooklyn College, with a specialization in Fiction. Read more of his work at http://jenzoduque.weebly.com/


case: the district
court’s interlocutory November 6, 2018 minute order denying appellant’s motion to
amend his complaint and his request to reconsider the court’s alleged “refusal to review
plaintiff’s pleadings in toto.”

        This court has jurisdiction over “appeals from all final decisions of the district
courts of the United States . . . .” 28 U.S.C. § 1291. Courts give 28 U.S.C. § 1291 a
“‘practical rather than a technical construction,’” and may therefore exercise jurisdiction
over “a ‘small class’ of collateral rulings that, although they do not end the litigation, are
appropriately deemed ‘final.’” Mohawk Industries, 558 U.S. at 106 (quoting Cohen v.
Beneficial Industrial Loan Corp., 337 U.S. 541, 545-46 (1949)).
                review of “[i]nterlocutory orders of
the district courts of the United States . . . granting, continuing, modifying, refusing or
dissolving injunctions, or refusing to dissolve or modify injunctions, except where a
direct review may be had in the Supreme Court.” 28 U.S.C. § 1292(a)(1). The order on
appeal here, however, had no such effect; it denied appellant’s motion for leave to file
an amended complaint, and addressed his concern that his race discrimination claims
had been improperly disallowed. It is

     FURTHER ORDERED that the motion for a preliminary injunction be dismissed
as moot.


mouth about people you don't know.

I said I have been waiting for 5 years for this game because GTA4 came out in 2008 and I didn't care for it a whole lot. It's not like i've been sitting at my computer for 5 years twitching and scratching my neck. For someone who doesn't care very much about this game, you sure feel the need to sit in the GTA5 thread and talk about it A LOT. Why don't you spend your time doing other things????

Err, mate? Why are you sounding angry? Is 'extreme gamer' an insult around here? Also, I never said I didnt care about the game, I couldnt after all I said in this thread before. In fact this is the only game i care about...Pleasedont twist my words...

One last thing, 'Please don't open your mouth about people you don't know'. Er mate what exactly were you doing in that message/comment/reply?

First sthing ill do is shoot a couple peeps to see how the mechanics improved, if the way they die is realistic or not. Im always interested in that for some reason. It wasmbad in uncharted for example

@Dre I feel the same. Whenever I play any game, particularly open world games I take a lot of time to go through it all. I'll be at this game for months and possibly years depending on how the online goes. I'm more of a SP person myself but we shall see.

I have this weird thing about side missions too. In between main missions I will