/*
 * Chinese AVS video (AVS1-P2, JiZhun profile) decoder.
 * Copyright (c) 2006  Stefan Gehrer <stefan.gehrer@gmx.de>
 *
 * MMX-optimized DSP functions, based on H.264 optimizations by
 * Michael Niedermayer and Loren Merritt
 *
 * This file is part of FFmpeg.
 *
 * FFmpeg is free software; you can redistribute it and/or
 * modify it under the terms of the GNU Lesser General Public
 * License as published by the Free Software Foundation; either
 * version 2.1 of the License, or (at your option) any later version.
 *
 * FFmpeg is distributed in the hope that it will be useful,
 * but WITHOUT ANY WARRANTY; without even the implied warranty of
 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
 * Lesser General Public License   OP(%%mm6, (%1), A, d)            \
        "add %3, %1                 \n\t"

/* vertical filter [ 0 -1  5  5 -1  0]  */
#define QPEL_CAVSV2(A,B,C,D,E,F,OP,ADD, MUL1, MUL2) \
        "movd (%0), "#F"            \n\t"\
        "movq "#C", %%mm6           \n\t"\
        "paddw "#D", %%mm6          \n\t"\


and define $V_S=\langle x_\beta(t):t\in K, \text{shape}(\beta)=S\rangle$.

\[abslem\] Let $G(K)$ be a split Chevalley group. For each $i\geq1$, $Q(i)/Q(i+1)$ has the structure of a $KL$-module with decomposition $Q(i)/Q(i+1)=\prod V_S$, the product over all shapes $S$ of level $i$. Furthermore, each $V_S$ is a $KL$-module with highest weight $\beta$ where $\beta$ is the unique root of maximal height and shape $S$.

This is the main result of [@abs], noting the Remark 1 at the end of the paper which gives the result even in the case $G(K)$ is special.

Throughout the paper we will need the restrictions $V_7\downarrow X$ of the seven-dimensional Weyl module $V_7:=W_{G_2}(\lambda_1)$ to various subgroups $X$ of $G=G_2(K)$. We calculate these now.

\[table\]The entries in the table following Corollary 3 have the restrictions $V_7\downarrow X$ as stated.

The restriction $V_7\downarrow X$ forcomplements to $Q$ in $\bar L_0 Q$.

We certainly have $X_{k,l}Q=\bar L_0 Q$ as $\bar L_0 Q$ is generated by $\{x_i(t)\}$ for $i\in\{1,2,3,4,5,6,-2\}$. It remains to show that $X_{k,l}$ is isomorphic to $A_1(K)$, and it follows that $X_{k,l}\cap Q=\{1\}$ as required.

To show this we will check the generators and relations given in [@ca 12.1.1 & Rk. p198], leaving us to show the following three statements hold:

1.  $x_{\pm}(t_1)x_\pm(t_2)=x_\pm(t_1+t_2)$,

2.  $h_+(t)h_+(u)=h_+(tu)$ and

3.  $n_+(t)x_+(t_1)n_+(t)^{-1}=x_{-}(-t^{-2}t_1)$,

for all $t_1,t_2\in K$ and $t,u\in K^\times$ where $n_+(t)=x_+(t)x_{-}(-t^{-1})x_+(t)$ and $h_+(t)=n_+(t)n_+(-1)$. We will abbreviate $n_{\alpha_i}(t)$ to $n_i(t)$, similarly for $h_{\alpha_i}(t)$.

Using the commutator relations for $G_2$ given in [@ca 5.2.2] we show that these relations hold.

Write $$\left[\begin{array}{c}i \\t\end{array}\right]:=x_i(t).$$

Firstly, item (i) is easily checked: no positive linear combination of roots $\alpha_2$, $\alpha_3$ and $\alpha_6$ is a root except for


3.3 these are represented by $X_{k,0}Q(2)$. Replace $X$ by a $Q$-conjugate to have $XQ(2)=X_{k,0}Q(2)$.

Now observe $XQ(3)/Q(3)$ is a complement to $Q(2)/Q(3)$ in $X_{k,0}Q(2)/Q(3)$. As $Q(2)/Q(3)$ is a trivial module for $X$, we have $H^1(X,Q(2)/Q(3))=0$ and we may replace $X$ by a $Q$-conjugate to have $XQ(3)=X_{k,0}Q(3)$.

Finally, observe that $X$ is a complement to $Q(3)$ in $X_{k,0}Q(3)$. As $Q(3)$ is a module for $X$ of high weight $2$, $H^1(X,Q(3))=K$ and $X_{k,0}Q(3)$ admits a one-dimensional collection of complements to $Q(3)$. By 3.4 these are represented by $X_{k,l}$. Thus we may replace $X$ by a $Q$-conjugate to have $X=X_{k,l}$.

Now, if $k=l=0$ then visibly $X_{k,l}\leq \bar L_0$ which we had earlier assumed was not the case.

The group $X_{k,l}$ is $P$-conjugate to one of $X_{1,0}$ or $X_{0,1}$.

If $k\neq 0$, we can conjugate the generatorsmust be irreducible or else it is in a parabolic; we have listed these in the table in Corollary 3. If $X\leq A_1\tilde A_1$, let the projection to the first (resp. second) factor be an isogeny induced by a Frobenius morphism $x\to x^{(p^r)}$ (resp. $x\to x^{(p^s)}$). We note some identifications amongst these subgroups:

When $p\neq 2$ and $r=s$ (without loss of generality $r=s=0$), $V_7\downarrow X=2\oplus 2\oplus 0$ which is the same as $V_7\downarrow Y$ where $Y:=A_1\hookrightarrow A_2$ where $Y$ acts irreducibly on the natural module for $A_2$. Indeed these are conjugate since $G$ acts transitively on non-singular 1-spaces (see [@lss Thm B]). When $p=2$ we get the subgroup $Z_1$. When $r=s+1$ and $p=3$, we have $V_7\downarrow X$ is a twist of $V_7 \downarrow Y$ where $Y$ is similarly irreducible


2:*]{}

If $X(q_0)$ has rank 2 then it is $^2 G_2(q_0)$, $G_2(q_0)$ or $A_2(q_0)$ and one can see that $X(q_0)\leq M$ where $M$ has ID (v)-(x) of the same type as $X(q_0)$: it is obvious for $X(q_0)$ of rank 2, $M$ cannot be as in cases (i)-(iv) and (xi); for cases (xii)-(xvi) one checks the appropriate pages in the Atlas [@atlas]. Such subgroups are unique up to $G_\sigma$-conjugacy by [@ls4 5.1]. Therefore we have $X(q_0)\leq \bar X$ a $\sigma$-stable subgroup of $G$ of the same type.

We now consider the case where $X(q_0)$ has rank 1. Here $X(q_0)\cong A_1(q_0)$. We show that each of these is contained in a $\sigma$-stable connected subgroup of type $A_1\leq G$. Let $X(q_0)\leq M$, a maximal subgroup of $G_\sigma$. Firstly, if $M$ is case (i)Atlas substantiate the fact that we must have $X(q_0)=L_2(7)$ or $L_2(11)$ (rather than $L_2(7^2)$ or $L_2(11^2)$ for example). Examining the 7-dimensional Brauer characters in the Modular Atlas [@modat] of $L_2(7)\leq G_2(2)$ and $L_2(7)\leq PGL_2(7)$ one sees that they are irreducible and therefore conjugate in $GL_7(7)$. Similarly, the Brauer characters of $L_2(11)\leq J_1$ and $L_2(11)\leq PGL_2(11)$ in $G_2(11)$ are the same irreducible representation and therefore conjugate in $GL_7(11)$. The result [@k 1.5.11] then implies that they are conjugate in $G(q_0)$. Thus in each case, the subgroup $X(q_0)$ is in the $\sigma$-stable maximal $A_1$ of $G$.

Let $M$ have ID (v)-(viii). If $X(q_0)$ is a subgroup of $SL_3(q)$ or $SU_3(q)$ and is distinct from those already considered, then $q_0$ is odd and $X(q_0)$ is irreducible on the standard modules in each


551-562. H. Andersen, J. Jørgensen and P. Landrock, The projective indecomposable modules of [SL]{}(2,$p^n$), [*Proc. London Math. Soc. (3)*]{} [**46**]{} (1983), no.1, 38-52. W. Bosma, J. Cannon, and C. Playoust, The Magma algebra system. I. The user language. [*J. Symbolic Comput.*]{} [**24**]{} (1997), no. 3-4, 235-265. R. W. Carter, Simple groups of Lie type, [*Wiley-Interscience*]{}, London, 1972. B. N. Cooperstein, Maximal subgroups of $G_2(2^n)$, [*J. Algebra*]{} [**70**]{} (1981), 23-26. J. H. Conway, R. T. Curtis, S. P. Norton, R. A. Parker and R. A. Wilson, Atlas of finite groups. Maximal subgroups and ordinary characters for simple groups. With computational assistance from J. G. Thackray [*Oxford University Press*]{}, Eynsham, (1985). N. Iwahori, Centralizers of involutions in finite Chevalley groups, [*Lecture Notes in Math.*]{} [**131**]{}, Springer, Berlin, (1970). C. Jansen,(red) and absence (black) of 43.6 μM RRM1/2/3/4-poly(A). The peak labels in the parentheses in panel (b) represent the minor peaks of the split signals. The 9 NMR signals with peak labels enclosed by the red box in the panel (b) did not disappear upon addition of RRM1/2/3/4-poly(A). (**d**) ^1^H-^15^N HSQC spectra of ^15^N-labelled Lt2 at 100 μM in the presence and absence of RRM1/2/3/4-A~24~ at 50 (blue), 100 (green) and 150 μM (red). The NMR signal of W437 in the black box is enlarged. (**e**) The estimation of the dissociation constant (*K*~d~). The chemical shift changes of W437 sidechain (sc), W437 and T438 were plotted against RRM1/2/3/4-A~24~ concentration in ^1^H-^15^N HSQC spectra of ^15^N-labelled Lt2 at 100 μM in the presence and absence of RRM1/2/3/4-A~24~ at 50, 100 and 150 μM. The


Figure [2](#MOESM1){ref-type="media"} show the superposition of the spectra of each PABPC1 region in the absence (black) and presence (red) of RRM1/2/3/4-poly(A). In Fig. [4b](#Fig4){ref-type="fig"}, 33 NMR signals for Lt2 exhibited significant line broadening upon addition of RRM1/2/3/4-poly(A), whereas only 9 NMR signals remained observed (Fig. [4b](#Fig4){ref-type="fig"}), clearly indicating that Lt2 binds to the poly(A)-bound RRM1/2/3/4. In contrast, the NMR signals for Lt1, Lt3, Lt4, or PABC showed no or subtle spectral changes upon addition of RRM1/2/3/4-poly(A) (Fig. [4c](#Fig4){ref-type="fig"}, and Supplementary Figure [2](#MOESM1){ref-type="media"}). This indicates that Lt2 contains a region that associates with poly(A)-bound RRM1/2/3/4.

NMR resonance assignments of the Lt2 signals (Supplementary Table [1](#MOESM1){ref-type="media"}) revealed that the signals for most Lt2 residues (residues 427 to 470) except for the N and C terminal 9 residues were broadened (Fig. [4b](#Fig4){ref-type="fig"}), presumably owing to the increase in thepoly(A)-bound PABPC1.Figure 5Identification of the RRM domain interacting with Lt2. (**a**,**b**) ^1^H-^15^N HSQC spectra of ^15^N-labelled Lt2 (100 μM) in the presence (red) and absence (black) of RRM1/2-poly(A) (200 μM) (**a**), and of RRM3/4-poly(A) (200 μM) (**b**). The peak labels in the parentheses in panel (a) are for the minor peaks of the split signals. (**c**,**d**) PRE results of ^15^N-labelled Lt2 in the presence of the A~24~-bound, spin-labelled RRM1/2/3/4. The intensity ratios of the ^15^N-Lt2 NMR signals are plotted in the presence of E29C‐MTSL (**c**) and D117C-MTSL (**d**). The intensity ratios were calculated by dividing the signal intensity of the radical (paramagnetic) form MTSL by the signal intensity of the reduced (diamagnetic) form of MTSL. \*Indicates Pro or residues without assignments.

We then tried to identify which of RRM1 or RRM2 acts


monomer and the multimer by the total intensity.

These results indicate that the Lt2 region largely contributes to the formation of the PABPC1 multimer on poly(A). As deletion of the Lt4 region, which is the same length as Lt2, showed much less effect on the multimerization, truncation of the linker itself did not impact the multimer formation. These data indicate that the residues in the Lt2 region identified by NMR analyses play an important role in the multimer formation of PABPC1 on poly(A).

PABPC1 multimerization is important for cap/poly(A)-dependent translation {#Sec9}
-------------------------------------------------------------------------

It has been reported that PABPC1 on the poly(A) tail of mRNA enhances translation in a cap/poly(A)-dependent manner^[@CR31]^. Here, we investigated the effects of PABPC1 multimerization on cap/poly(A)-dependent translation by using PABPC1ΔLt2 as a multimerization-deficient mutant in a cell-free translationparamagnetic relaxation enhancement (PRE) analysis, the E29C or D117C mutant of Cys-less RRM1/2/3/4 (C43S, C128S, C132S, and C339S of RRM1/2/3/4) was cloned into the pGEX-6p-1 vector and purified in the same manner as PABPC1. These purified proteins were incubated overnight with 10 mM DTT at 4 °C. After removal of DTT by dialysis, a 10-fold excess of (1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl) methanethiosulphonate (MTSL) was added to introduce a spin label onto the protein. The samples were incubated overnight at 4 °C in the dark. The MTSL modification was confirmed by mass spectroscopy. ^1^H-^15^N HSQC spectra of ^15^N-labelled Lt2 (100 μM) with the MTSL-modified protein (40 μM) and A~24~ (40 μM) were acquired in the presence and absence of 2 mM ascorbate at 288 K in a buffer containing 20 mM KH~2~PO~4~ (pH 6.0), 150 mM NaCl, and 10% ^2^H~2~O.

*In vitro* translation


less – half of its working force, as emphasized by A. Weber in “What women do”. In conclusion, a new suggestion comes out: the optimal worker of the future is a perfect synthesis of both male and female personalities.

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Work Style is a publishing company focusing on the world of work. It provides factual contents that are specific to the everchanging working world. Its products are multicultural and divulged with a multiplatform strategy. Its offer is characterized by editorial products and meeting opportunities.

The online shop is the collection point of our editorial products. Here you can purchase all the magazine’s issues, subscribe to our publication or purchase the photographic book Rules and Passion, a journey in the world of the Pure Spanish Horse.

Law & Cooking, Rules and PassionMy Sincere Apology

Just over twenty-four hours ago, I posted a picture of the front page of the New York Times with seven 9mm bullet holes that I had fired into it from top to bottom of their anti-gun editorial.

The ensuing reaction over these past twenty-four hours have convinced me I must apologize. My conscience convicts me that I made a major error.

In all honesty, had I known that these last twenty-four hours would be as hysterically funny as they have been, I would have shot the front page of the New York Times well before today.

These people are insane, filled with rage, and flat out funny. Suggesting that shooting the front page of the New York Times is the equivalent of ISIS destroying Palmyra and killing its citizens


Despite increased interest, how H3.3 contributes uniquely to the function of chromatin is a long-standing, unanswered question in the field. We propose an innovative program combining mouse genetics, biochemistry, chemical biology, and cutting-edge genomics to understand the functional relevance of H3.3-mediated chromatin dynamics. Our central hypothesis is that H3.3 deposition promotes the establishment of unique developmentally regulated chromatin landscapes that allow appropriate cell fate decisions to be made. Our preliminary data suggests that nucleosome turnover rates are reduced in the absence of H3.3, and that H3.3 dynamics may facilitate histone post-translational modification states at specific genomic regions. Over the course of our studies we will (1) define the mechanisms underlying H3.3 function in promoting specific histone post-translational modification states, (2) identify regulatory mechanisms that control deposition of H3.3Reassuring effect of pravastatin on natural killer cell activity in stable renal transplant patients.
Administration of pravastatin soon after transplantation successfully lowers cholesterol levels, whereas a reduced number of acute rejection episodes is accompanied by a decrease in natural killer (NK) cell activity. As a consistent low NK cell activity caused by pravastatin might impair tumor surveillance leading to cancer, we studied the effect of pravastatin on NK cell activity in stable renal transplant patients. From 14 cyclosporine (CsA)-treated and 11 azathioprine (AZA)-treated patients with hypercholesterolemia, more than 1 year after kidney transplantation, we determined NK cell number and cytotoxic activity before, and at 6 and 12 weeks after, initiating pravastatin treatment. Additionally, cholesterol levels and liver and kidney function parameters were assessed. During pravastatin treatment, total cholesterol and


In fact, he was pretty bad. He didn't know anything, but he's done a great job."

``He has all the skills," added McClanahan. "Great hands, good footwork. He just had to learn by playing. He has great work ethic and loves to play."

Thabeet had only played basketball for two years when he arrived in Houston. Like many kids in his homeland, he grew up playing soccer.

Thabeet runs the court extremely well for someone his size. He's also capable of scoring in the low-post, although he still needs to work on a go-to move. Part of the problem is that when he gets the ball in the paint, the easiest thing for him to do is just dunk over his defender.

Thabeet's biggest asset, though, is his ability to rebound andQ:

.toLowerCase in javascript "not a function"?

I'm trying to do something like this
if (pathArray.toLowerCase().indexOf("blah") != -1{}

When debugging with console I get the error that "pathArray.toLowerCase is not a function". Why do I get that message?

A:

toLowerCase is a method of the string. If you want to be able to find a string in array without knowing exact case you can add map step to the chain:
pathArray.map(function(s) { return s.toLowerCase(); }).indexOf('blah') !== -1

A:

toLowerCase() is only for strings, but I have a feeling that your "pathArray" is, in fact, an array.
> 'hello'.toLowerCase()
'hello'
> ['hi', 'bye'].toLowerCase()
TypeError: undefined is not a function

Are you trying to check if "blah" exists in your array in any uppercase / lowercase form?


modes,
 * which can be set via the sntp_set_sync_mode() function.
 * Two modes are available:
 * - the first is an immediate update when receiving time from the sntp server,
 * - the second is a smooth time update (if the time error is no more than 35 minutes,
 *   and an immediate update if the error is more than 35 minutes).
 *
 * To receive notification of time synchronization,
 * you can use the callback function or get the synchronization status
 * via the sntp_get_sync_status() function.
 *
 * To determine the time synchronization time on the device, you can use:
 * 1) sntp_set_time_sync_notification_cb() function to set the callback function,
 *    which is convenient to use to receive notification of the update time.
about 70 members. Identification of the lowest mass objects in the NGC 1333 cloud, as well as estimates for their ages and masses, requires infrared spectroscopy. Ultimately, the population of very low mass objects will be used to define the shape of the mass function and determine the number and total mass of brown dwarfs in the young cluster.

Source Selection and Observations
=================================

Brown dwarf candidates were selected by comparing their positions in a near-infrared color-magnitude diagram with theoretical models for pre-main sequence objects by D’Antona & Mazzitelli (1997, 1998, hereafter DM97). An age of 1 Myr was assumed (Lada 1996). Near-infrared surveys of the northern cluster (Wilking 2002) and the southern cluster (Aspin 1994) were used to construct the K vs. (H-K) diagram. The majority of the 25 candidates lie


warmer than dwarfs by 300–500 K for stars of the same spectral type (e.g., Fig. 4 in Itoh 2002). Hence by assuming a dwarf surface gravity, we may be underestimating the effective temperature of an M2 subgiant by $\sim$150 K and of an M6–M9 subgiant by $\sim$250 K.

In Fig. 2, we have plotted our brown dwarf candidates on Hertzsprung-Russell diagrams overlaid with the theoretical tracks and isochrones from the models of of DM97 and Burrows et al. (1997). An H-R diagram using the Baraffe (1998) models is presented in Wilking (2002). For the DM97 models, mass estimates range from $<$0.02 M$_{\sun}$ to 0.25 M$_{\sun}$, with 16 objects at or below the hydrogen-burning limit. The median age for the sample is 0.3 Myr. If a temperature scale intermediate betweenTalents

Patch 7.07b brought some changes:

Level 15 changed from Blink Uncontrollable Illusion to +15 Agility

Level 20 changed from +10 All Stats to Blink Uncontrollable Illusion

Now you can't have both the illusion and the +300 Blink range - honestly, I would pick the former most of the times. Instead, at level 15 you can opt for the -1s Blink cooldown, reducing it to only 4 seconds once maxed.

20 (Blink Uncontrollable Illusion)

This talent spawns an uncontrollable illusion when you blink. Of course, this illusion alone can’t replace the Manta Style, but is still very useful because it procs Mana Break.

Can’t be controlled

Target acquisition radius of 600

If no target is in the radius, the illusion will stand idle until an enemy enters in the radius

Attacks neutrals only when you are in their


/*
 * jversion.h
 *
 * Copyright (C) 1991-2016, Thomas G. Lane, Guido Vollbeding.
 * This file is part of the Independent JPEG Group's software.
 * For conditions of distribution and use, see the accompanying README file.
 *
 * This file contains software version identification.
 */

#define JVERSION	"9b  17-Jan-2016"

#define JCOPYRIGHT	"Copyright (C) 2016, Thomas G. Lane, Guido Vollbeding"
We create and consume data everyday, from the moment we wake up and reach out to our phone to see what happened while we were sleeping to the moment we go to bed and finish up our day’s last social media posts. Users use countless apps to consume and create data while those service providers of apps and third-parties are making billions from our data. Profede is unique in that it is offering professionals a way to earn tokens each time that they approve and authorize to share their professional data with a new contacts. Through the use of Profede’s protocol users can enjoy using their social networks while being part of the profit equation.

Profede is a unique blockchain-based protocol in the professional industry. Here’s why:

1. A protocol


We are delighted to announce that the London Eurovision Party will be returning for its tenth anniversary on Sunday April 2nd at the promo eurovision song contest 2017 promo the entertainment spectacle of the year is back on logo! catch the eurovision song contest live on saturday, may 13 3p et. Eurovision Song Contest 2017 betting odds die eurovision ist eine 1954 in genf gegründete einrichtung der union der europäischen rundfunkorganisationen zum austausch von fernseh-und hörfunkprogrammen. Click to view odds for the Eurovision Song Contest the official website of the eurovision song contest, with the latest news, photos, videos and info about the participants, the upcoming shows and its history. Vom 9 eurovision song contest (engelsk), concours eurovision de la chanson (fransk) eller eurovisjonens sangkonkurranse, på norsk ofteand L segments or with L-A virus genomic and transcript RNA ([Fig. 2b and c](#F2){ref-type="fig"}). In all cases, the stimulatory activity of RNA associated with RIG-I precipitates was lost after treatment with phosphatase ([Fig. 2b and c](#F2){ref-type="fig"}). Thus, RIG-I can directly bind viral RNAs bearing 5′-diphosphates.

Previous data suggested that *in vitro* transcribed (IVT)-RNA with a 5′pp does not serve as a RIG-I agonist^[@R17]^. The IVT-RNA in question bore a single guanosine residue at the 5′ end to permit generation of 5′pp when GDP instead of GTP was included in the transcription reaction^[@R17]^. However, because transcriptional elongation requires a triphosphate-bearing nucleoside to form the phosphodiester bond, GDP also prevented the generation of the polymerase copy-back IVT base-paired by-products later demonstrated to be required for RIG-I stimulation^[@R18],[@R19]^. We therefore re-synthesised


cells in a RIG-I-dependent manner ([Fig. 3f,g](#F3){ref-type="fig"}) and only 3-fold less active than the 5′ppp-RNA^24nts^+AS control ([Fig. 3f](#F3){ref-type="fig"}). Binding assays showed that RIG-I has similar affinity for both RNAs (apparent K~d~ of 16.7 nM for 5′pp-RNA^24nts^+AS *versus* 9.4 nM for 5′ppp-RNA^24nts^+AS) but binds 5′p-RNA^24nts^+AS much more weakly ([Fig. 3h](#F3){ref-type="fig"}). The latter also failed to induce IFN ([Fig. 3f](#F3){ref-type="fig"}), consistent with reports that ligand binding is necessary but not sufficient for RIG-I activation^[@R10],[@R21]^. Altogether, we conclude that, similar to natural 5′pp-containing viral RNA, man-made 5′pp-base-paired RNAs trigger a RIG-I-dependent response.

Lastly, to assess the physiological importance of our findings, we studied the innate immune response to reovirus infection in MDA5- or MAVS-deficient cells and mice. At 48 h post-infection, there was an increase in reoT3D S4 genome segment copy numberlittermate control MEFs were prepared from 12.5-day embryos using standard protocols. RIG-I/MDA5-deficient MEFs were generated by CRISPR-Cas9-mediated genome engineering^[@R27]^. A target sequence in the first exon of murine RIG-I (CTACATGAGTTCCTGGCTCG [AGG]{.ul} \[PAM motif underlined\]) was chosen and appropriate oligonucleotides were cloned into the BbsI site of pX458 (pSpCas9(BB)-2A-GFP; obtained from the laboratory of Feng Zhang *via* Addgene (Cambridge, MA; plasmid 48138)) according to the cloning protocol provided by the Zhang lab ([www.genome-engineering.org](http://www.genome-engineering.org)). MDA5-deficient MEFs immortalized with simian virus 40 large T antigen^[@R7]^ were transfected with the RIG-I targeting pX458 vector using Lipofectamine 2000 (Life Technologies) according to the manufacturer's instructions. Twenty-four hours post-transfection, GFP-positive cells were FACS sorted and cultured at limiting dilution to pick individual colonies. The absence of functional RIG-I was verified in several clones by


vivo* assays, reovirus S4 vRNA was quantified using 1-4 μg of total RNA extract. Forward (S4 83F, 5′-CGCTTTTGAAGGTCGTGTATCA-3′) primer was used for reverse transcription before reverse (S4 153R, 5′-CTGGCTGTGCTGAGATTGTTTT-3′) primer was added for qPCR amplification. The S4-specific fluorogenic probe used was 5′-dFAM-AGCGCGCAAGAGGGATGGGA-BHQ-1-3′ (Biosearch Technologies, Petaluma, CA). After denaturing RNA for 3 min at 95°C, reverse transcription was performed for 15 min at 50 °C and terminated by incubation for 3 min at 95°C. Subsequently, 40 cycles of qPCR were performed (95°C for 15 sec; 60°C for 30 sec). Reovirus S4 copy numbers were calculated relative to a standard curve prepared using 10-fold dilutions of purified reovirus T3D vRNA as template RNA. The final S4 RNA copy number was normalized to the total sample RNA used per reaction. Themin at 25°C with (His~6~)-FLAG-RIG-I-binding nickel-chelate acceptor beads (Perkin-Elmer) and biotin-RNA-binding streptavidin donor beads (Perkin Elmer).

Liquid chromatography-mass spectrometry (LC-MS) analysis {#S14}
--------------------------------------------------------

Samples of GMP, GDP, and GTP were analysed by LC-MS using an Agilent 1100 LC-MSD. Analysis was carried out using a Zorbax Eclipse XDB-C8 Rapid Resolution HT 3.0 × 50 mm 1.8 micron column. Buffer A is 1% acetonitrile and 0.08% trifluoroacetic acid in milliQ water, and Buffer B is 90% acetonitrile and 0.08% trifluoroacetic acid in milliQ water. Flow rate was 0.425 mls/min, and the gradient was 0% -- 40% Buffer B over 8 min. The MS was conducted with positive polarity, fragmentor voltage was 170, drying gas flow 12 L/min, drying gas temperature 350°C, and nebuliser pressure 40 psig. Mass spectra were registered in full-scan mode


for 16 h, the relative expression (RE) of *ifit1* over *gapdh* (c) or murine IFN-α levels (d) were determined. Water and ppp-IVT-RNA^99nts^, poly(dA:dT), or RNA isolated from Vero cells infected with encephalomyocarditis virus (Vero-EMCV-RNA) were included as controls (\* = none detected). All experiments were performed at least twice; one representative experiment is shown.

###### RIG-I associates with stimulatory RNA following reovirus infection.

This experiment was conducted exactly as in [Fig. 2a](#F2){ref-type="fig"} but using strain reoT3D.

###### Characterization of guanosine sources and IVT-RNA^25nts^.

**(a)** Representative LC-MS spectra of GMP, GDP, and GTP sources used for the preparation of IVT-RNAs in [Fig. 3](#F3){ref-type="fig"}. Asterisks indicate the expected mass-to-charge ratio (m/z) of the different guanosines. **(b)** IVT-RNA^25nts^ were generated as depicted in [Fig. 3a](#F3){ref-type="fig"} using GMP, GTP, or GMP spiked with GTP (GMP +{
        //@formatter:off
            $builder
                ->add('initialState', EntityType::class, array(
                    'class'             => State::class,
                    'choice_label'      => 'key',
                    'choice_value'      => 'key',


Description: The first journal exclusively dedicated to the reception of Greek and Roman antiquity by other cultures, from the ancient world to the present time, International Journal of Classical Tradition's primary focus is on the creative use of the ancient Greco-Roman heritage in a broad range of scholarly endeavors. Articles are published in five languages. The journal includes articles, short notes, research reports, review articles, and news of the field. The official journal of the International Society for the Classical Tradition.

The "moving wall" represents the time period between the last issue
available in JSTOR and the most recently published issue of a journal.
Moving walls are generally represented in years. In rare instances, a
publisher has elected to have a "zero" moving wall, so their current
issues are available in JSTOR shortlyperipheral material, Wilson masterfully directed his readers' interpretation of the text. He unequivocally advocated military intervention in the Netherlands as the consequences of inaction would be dire: England would lose its current bulwark against Spain's military might, just as Athens had lost Olynthus. Wilson deliberately appealed to the intellectual background of those Tudor statesmen who formed the 'Cambridge Connection' in the Elizabethan government. Moreover, he articulated his message without compromising the integrity of Demosthenes' text or his own humanist credentials. By subtly reconfiguring the role of Demosthenes from orator to statesman, Wilson gave his orations greater political authority. Wilson's Demosthenes also marked an important moment in English intellectual history: it clearly politicises classical translation.


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       three different protocols to prepare the initial loose samples, they are indicated by different symbols in the figures below. However, our results do not seem to depend on the initial preparation method, details of which can be found in the supplemental material. Except for the loosest samples, the packings are compactified by applying sinusoidally shaped pulses on an electromagnetic shaker (LDS V555). The width of the pulses is 50 ms and the peak acceleration 2 $g$ (where $g=9.81 \mathrm{m/s^2}$). At a repetition rate of 3 Hz up to 1500 taps are applied to prepare the highest values of $\phi_g$.

[*Image analysis. –*]{} Tomograms of the prepared packings are acquired using X-ray computed tomography (GE Nanotom) with a resolution of 64 $\mu$m per voxel. The resulting three-dimensional gray scale image


in its programmed (conductive) state and in its erased (nonconductive) state. A voltage Vr is applied to the electrode 36 so that an electrical potential across the memory device 30 from a higher to a lower electrical potential in the same direction as in the programming and erase steps. This voltage Vr is lower than the voltage Vpg applied for programming and is lower than the voltage Ver applied for erasing (see above). In this situation, if the memory device 30 is programmed, the memory device 30 will readily conduct current (level L1), indicating that the memory device 30 is in its programmed state. If the memory device 30 is erased, the memory device 30 will not conduct current (level L2), indicating that the memory device 30 isFormer players slam PCB for sacking Sarfaraz as captain in all three formats

Pakistan coach Misbah-ul-Haq and bowling coach Waqar Younis were also targeted and blamed for engineering the ouster of Sarfaraz.

Sarfaraz Ahmed has been replaced as Test captain by Azhar Ali while Babar Azam will take over in T20s. (Photo: Twitter)

Karachi: Pakistan's former stalwarts on Sunday lashed out at the Pakistan Cricket Board (PCB) for acting in haste in removing Sarfaraz Ahmed as captain in all three formats of the game.

Most of the former captains and players termed the removal of Sarfaraz on Friday as unjust. Not surprisingly the head coach and chief selector Misbah-ul-Haq and bowling coach Waqar Younis were also targeted and blamed for engineering the ouster of Sarfaraz.

Sarfaraz has been replaced as Test captain by


and manage
Islamist terrorist and related groups (for instance, the
'Kosovo Liberation Army' terrorists). For Washington,
organized terror is a weapon of Empire. - Jared Israel.

Anatomy of a Victory: CIA's Covert
Afghan War

By: Steve Coll, 'Washington Post', July 19, 1992

A specially equipped C-141 Starlifter transport
carrying William Casey touched down at a military air
base south of Islamabad in October 1984 for a secret
visit by the CIA director to plan strategy for the war
against Soviet forces in Afghanistan. Helicopters lifted
Casey to three secret training camps near the Afghan
border, where he watched mujaheddin rebels fire heavy
weapons and learn to make bombs with CIA-supplied plastic
explosives and detonators.

During the visit, Casey startled his Pakistani hosts
by proposing that they take the Afghan war into enemy
territory -- into the Soviet Union itself. Casey wanted
to ship subversive propaganda through Afghanistanbattlefield
communications equipment, referred to by some as the
"Omsk vans" -- mobile, integrated
communications centers that would permit interception of
mujaheddin battlefield communications and rapid,
coordinated aerial attacks on rebel targets, such as the
kind that were demoralizing the rebels by 1984.

At the Pentagon, U.S. military officers pored over the
intelligence, considering plans to thwart the Soviet
escalation, officials said. The answers they came up
with, said a Western official, were to provide "secure
communications [for the Afghan rebels], kill the gunships
and the fighter cover, better routes for [mujaheddin]
infiltration, and get to work on [Soviet] targets"
in Afghanistan, including the Omsk vans, through the use
of satellite reconnaissance and increased, specialized
guerrilla training.

"There was a demand from my friends [in the CIA]
to capture a vehicle intact with this sort of
communications," recalled Yousaf, referring to the
newly introduced mobile Soviet facilities. Unfortunately,
despite


12,000 square feet, decreasing the minimum rear setback from 25 feet to 5 feet and allowing units as large as 1,200 square feet, the maximum allowed by state law, from the current city standard of 800 square feet.

Resident Jamie Lee said, as written, the first two requirements significantly limit how many properties could build an accessory dwelling unit — only 25 percent of residential properties in West Covina are at least 12,000 square feet, according to a city staff report — and the third requirement unnecessarily limits the amount homeowners can increase their property values.

“For people to support these rules, you have to have rationale or principles behind them,” Lee said at Tuesday’s commission meeting, advocating for the changes.

Commissioners Donald Holtz and Herb Redholtz said they were inLast updated on .From the section Championship

Reading's Yakou Meite celebrates scoring his fifth league goal this season

An 84th-minute header from Yakou Meite gave Reading a draw with Ipswich, after the visitors had led for the majority of the game.

Gwion Edwards scored inside five minutes for Ipswich with a right-footed shot that found the bottom left corner from outside the box.

It took the home side just two minutes to equalise with Meite's overhead kick.

The Tractor Boys responded once more in the 11th minute, as a mix-up at the back for Reading gave Freddie Sears the chance to get through on goal and slot past keeper Anssi Jaakkola.

However, Meite's late header from Leandro Bacuna's pass secured a point for the hosts.

New Ipswich manager Paul Lambert is still without a win


$T_0,\dots,T_3$ with local hypothesis $i$ at step $t$ is denoted by $l_{t,i}$. In case of instantaneous decisions (left) only the best local hypothesis at each instant is retained (marked in blue). In the case of MHT with search depth $3$ (right), the decision at $T_1$ is based on the best global hypothesis at step $T_3$, marked with blue edges. Once the decision at $T_1$ has been made, hypotheses that are not children of the best node are discarded, shown in red.[]{data-label="fig:comparison"}](hypTree.eps)

In this work, we investigate the feasibility of using multiple hypothesis tracking (MHT) [@reid1979algorithm; @blackman2004multiple] – a well known decision making paradigm in multi-target tracking – for segmenting trees. In methods based on region growing [@lo2010vessel] and conventional object tracking [@yedidya2008tracking], segmentation decisions are made instantaneously rendering them susceptibe to localon right. Notice how the scores of the best hypothesis at each scale varies for the Original MHT method.[]{data-label="fig:varyingDim"}](ranking_hyp.eps)

An important factor to consider when tracking tree-structures with branches of varying dimensions is the range of their radius. With airway trees for instance, the radius of visible airways in CT typically ranges from $1$mm to $10$mm. When using the Original MHT method, such variations make it hard to obtain optimal parameter settings across scales. This behaviour is demonstrated for local hypothesis scores, computed using Eq. , in Figure \[fig:varyingDim\]. Specifically, local hypothesis scores tend to decrease with scale, making it challenging to obtain a single optimal local threshold that works well across scales. When the local threshold is tuned to extract smaller branches, the chance of adding large and sub-optimal branches


value]{}. $^+$ We refer to the text in Section \[sec:awExp\] for explanation on *Global threshold* for the Original MHT method and two different ranges for *Weight window*.[]{data-label="tab:param"}

The Modified MHT method was compared to the Original MHT method and with region growing applied to both the probability and intensity images. Parameters of all the methods were tuned on the training set comprising 16 images and tested on an independent test set consisting of 16 images. Both the MHT methods have tunable parameters; the first set of parameters is related to the tubular template: minimum and maximum allowable radii of the templates, scaling factors for step length and weight window. A second category of parameters is related to multiple hypothesis tracking: search depth, search angle, number of angles, local and globalthe case of probability images based on the training set performance was found to be $0.5$. All four methods require an initial seed point and the same seed point in the trachea, automatically extracted using the procedure described in Lo et al. [@lo2010vessel], was provided to all.

We use the MHT module in MeVisLab provided by the authors in Friman et al. [@friman2010multiple] to perform the Original MHT experiments. In this implementation, minimum value for the weight window factor is constrained to be $3$. However, for the Modified MHT method we tried a larger range $[1, 2, \dots, 5]$, and found the training error to be slightly lower (by $0.2$mm) when compared to using the smaller range $[3,4,5]$. We adhere to using this larger range for Modified MHT method, and a


along with the search range of parameters. Parameters with \* were fixed based on the morphology of vessels. $^+$ We refer to the text in Section \[sec:corExp\] for explanation on *Global threshold* for the Original MHT method and two different ranges for *Weight window*.[]{data-label="tab:coronary"}

As with the airway tree extraction experiments in Section \[sec:awExp\], most of the parameters are tuned for both MHT methods, while some are fixed based on prior knowledge. The minimum and maximum radii parameters are set to 1mm and 3mm, respectively. [ *Search depth* was fixed to be $4$ which is the same as the one used in Original MHT work for fair comparison [@friman2010multiple].]{} Remaining parameters are tuned to maximise overlap, OV, on the training set and are summarised in Table \[tab:coronary\]. Further, as with the airway experiments,Google just spilled the beans on a Windows 8.1 vulnerability that could give an attacker elevated privileges and Microsoft is not happy about it.

Currently, Google’s policy is to publish any vulnerabilities it finds 90 days after notifying the software vendor of the issue. Google publicized this latest flaw on Google Code on Sunday before Microsoft had a chance to release a fix. A similar Windows bug was publicized in late December.

What’s got Microsoft so miffed is that Google released the information just two days before the Windows maker planned to release a fix during the company’s usual “patch Tuesday” on January 13, 2015. What’s more, Microsoft claims it was in touch with Google and that the search giant was well aware of Microsoft’s timeline.

“The decision [to publish the


days when Microsoft had already promised a fix?

Putting companies on a deadline for timely, responsible patching is a great policy to have. Keeping to that deadline even when a promised fix is mere days away, however, doesn’t help users. It just makes Google look like it’s trying to stick it to Microsoft.lawyers will then go to the appellate court, Smith said.

He acknowledged it was all quite confusing.

"This case certainly has a lot of moving parts," Smith said.

Earlier, when Donald Sterling's writ request was filed, Ballmer's lawyer quickly denounced the move.

Lawyers for Sterling had asked the Second District Court of Appeal to stay Levanas' ruling that cleared the way for the sale. They said the judge prematurely finalized his ruling so the sale can be completed without a chance to appeal.

Sterling's appellate lawyers said in their request for a writ of mandate that if the sale goes through, "Donald will have lost a unique and irretrievable asset: a `trophy asset' coveted by high net worth individuals around the world -- one of thirty NBA franchises in the country, and one


Time to complete mixing for the measurement of glomerular filtration rate from single bolus plasma 51Cr-EDTA clearance.
In the measurement of glomerular filtration rate from the plasma clearance of 51Cr ethylenediamine tetraacetic acid by using the slope-intercept method, the first sample is conventionally taken at 2 h, the time by which it is generally assumed that the clearance curve has reached a single exponential. We examined this assumption by comparing the slopes, alpha 12 and alpha 23, based, respectively, on samples at 2 and 3 h, and at 3 and 4 h. In 421 patient studies in whom the first sample was taken between 110 and 130 min after injection, the mean ratio, alpha 12/alpha 23, was 1.101 (SEM 0.011) which is significantly higher than unity (P<<0.001). The relationshipdrive mechanism for driving the transfer assembly to move the lugs at a speed less than the speed of the first conveyor. Each of the lugs has an engaging member and a weighted portion for pivoting the lugs as they travel on the transfer assembly so that the engaging member can engage a leading edge of an item while it is moving on the first conveyor to catch the item and separately deliver that item to the lifting assembly.
Advantageously, the indexing and lifting apparatus of the present invention is particularly well suited to high speed operation of first and second conveyors. Further, the indexing and lifting apparatus is particularly suited for items with sides that are perpendicular to their bottoms, thus providing a leading edge for engaging the


Vail Town Council to take up Ford Park issue

Related Media

VAIL, Colorado - The Vail Town Council will be taking input from the public regarding possible amendments to the Ford Park planning documents during its evening meeting on Tuesday. The item is listed fourth on the meeting agenda which begins at 6 p.m. in the Vail Town Council Chambers, 75 S. Frontage Road.

Members of the public are encouraged to review the documents in advance of the meeting. Included will be a review of the 1985 Ford Park Master Plan and a question as to whether amendments to the-Ford Park Management Plan, adopted in 2012, should be included in the master plan.

The-review follows a Town Council decision earlier this month to withdraw its consent to proceed through the development reviewEarly Look At the Pittsburgh Pirates 2014 Payroll

Yesterday I looked at the 2013 payroll in a way-too-early projection. It’s hard getting an estimate for the 2012 payroll, and that’s only a few months away. The 2013 payroll seemed impossible due to all of the variables that can take place between now and the start of the 2013 season. So the 2014 payroll would be impossible to project. But we’re not looking for accuracy here. We’re just looking to get an idea of where the payroll will end up. Here is the 2014 projected payroll, as well as notes on what went in to the projection.

Some notes before we go on:

-All projections were made with the assumption that the player played on the same level as the 2011 season.


be down to about $34 M in payroll, giving them a lot of room to work with to support the rest of the team.

First Year Arbitration Eligibles

The big arbitration decision here will be Pedro Alvarez. It’s really hard to estimate what he could make, since he’s coming off a horrible year. If he doesn’t rebound, he probably won’t be on the team at this point. If he does rebound, it’s a question of how well he does. If he manages to live up to his potential, he could make at least $6 M in his first year of arbitration, if not more.

Leroux and McCutchen are both first year arbitration eligible. Their amounts might seem high, although they’re both innings eaters in the bullpen, which should increase their value.

Making <para>Use the <see cref="T:System.Security.Cryptography.Xml.DataObject" /> class to store information or metadata directly in an XML signature.  For example, you can store the signature generation date or the signer's identity.  The <see cref="T:System.Security.Cryptography.Xml.DataObject" />  class may or may not be covered by the XML signature.   </para>
      <para>The class corresponds to the <Object> element in the World Wide Web Consortium (W3C) specification for XML Signatures. For more information about the W3C specification, see <see cref="http://www.w3.org/TR/xmldsig-core/">http://www.w3.org/TR/xmldsig-core/</see>.</para>
    </remarks>
    <summary>
      <attribution license="cc4" from="Microsoft" modified="false" />
      <para>Represents the object element of an XML signature that holds data to be signed.</para>
    </summary>
  </Docs>


  <value>a <see cref="T:System.String" /></value>
        <remarks>
          <attribution license="cc4" from="Microsoft" modified="false" />
          <para>The identification is used to reference the <see cref="T:System.Security.Cryptography.Xml.DataObject" /> from another location. The default value of this property is null, which implies that no identification is present. This property is commonly referenced by the <see cref="P:System.Security.Cryptography.Xml.Signature.SignedInfo" /> property.</para>
        </remarks>
        <summary>
          <attribution license="cc4" from="Microsoft" modified="false" />
          <para>Gets or sets the identification of the current <see cref="T:System.Security.Cryptography.Xml.DataObject" /> object.</para>
 Q:

Trying to install Rails and create new project, but not possible

I know there are many similar questions but I couldn't find any suitable answer for mine from previous questions, please don't flag this questions as already existing. I would be very grateful if someone help me get going with my rails project on my laptop.
First of all I want to say few things which I have tried. I have been able to successfully install Rails on my personal pc using Rails installer and I have started and done few sample app/ projects.
BUT THE PROBLEM IS WHEN I AM TRYING TO INSTALL RAILS ON MY WORK(COMPANY) LAPTOP(Windows Vista) and start a new rails project I think the proxy is blocking gem install but I dont know how to overcome


one client has UPNP support and the other doesn't or doesn't have it enabled. If your machine is behind a NAT device that supports UPNP, that's probably the reason.

A:

If you want to enable inbound connections and thus have more than 8, most likely what you need to do is forward port 8333 on your router.

v and 4.
4
Suppose -5*h = -3*r - 4047, -3*r + 11 = 8. What is the highest common factor of 36 and h?
18
Let f(t) = -23*t**3 - t**2 + 1. Let r be f(-1). Suppose 7*n - 6*n - r = 0. Let s be (n/7 + -3)*14. Calculate the greatest common divisor of 12 and s.
4
Suppose -6*b - 61 + 13 = 0. Let q = b + 11. Suppose p = -q*i + 43, 4*i - 3*i = 4*p + 23. Calculate the highest common divisor of 45 and i.
15
Let c = 56 + -26. Let b(k) = 3*k - 33. Let m(x) = -2*x + 3. Let z be m(-6). Let p be b(z). What is the highest common divisor of p and c?
6
Suppose -5*g


Q:

Hierarchy taxonomy terms for node path in drupal 7

I have a vocabulary with 3 levels and a node type with a term reference to that vocabulary.
When I create a node of that type I choose a term in the deepest level of the vocabulary and now the question comes.
I have pathauto module installed and I'd like to build a pattern like this:
[node:field_category:level-1]/[node:field_category:level-2]/[node:field_category:level-3(deepest)]/[node:title]
The problem is that can't find the right token to achieve this behaviour. This afternoon I have been searching the web and I can't find a solution.
Any ideas? ( I'm using Drupal 7)

A:

The following solution works for me:
[node:field-yourfield:parents:join:/]/[node:title]

where yourfield stands for the name of your reference field.
Then you have to go into Configuration » Search and metadata » URL aliases Settings and under Punctuation changecompared between various subgroups and clinicopathologic factors of DLBCL, i.e., EBV-positive vs. EBV-negative cases; GCB vs. non-GCB/ABC type; and nodal vs. extranodal cases. Based on comparisons of mean values using independent t-tests, miR-197 expression levels were not significantly associated with EBV status, nodal/extranodal, stages (I, II vs. III, IV) and IPI (0--2 vs. 3--5). The non-GCB subtype tended to have low miR-197 expression levels, but the result did not achieve statistical significance (p = 0.253).Fig. 2Relative miR-197 expression level based on clinicopathologic variables and progression status. Relative miR-197 expression levels did not differ based on Hans classification (**a**), EBV infection (**b**), primary site (**c**) or Ann Arbor stage (**d**) in the full cohort of diffuse large B-cell lymphoma (n = 51). MiR-197 levels tended to be reduced in the progression group


and approved the final manuscript.

Acknowledgements {#FPar1}
================

Not applicable.

Competing interests {#FPar2}
===================

The authors declare that they have no competing interests.

Availability of data and materials {#FPar3}
==================================

The datasets during and/or analyzed during the current study available from the corresponding author on reasonable request.

Consent for publication {#FPar4}
=======================

Not applicable.

Ethics approval and consent to participate {#FPar5}
==========================================

The Institutional Review Board of Seoul National University Bundang Hospital (IRB of SNUBH) approved this study, and informed consent was waived by IRB of SNUBH because this study used archived materials with retrospective design.

Funding {#FPar6}
=======

This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) of Korea funded by the Ministry of Education (NRF-2016R1D1A1B03935507) and a Grant (03-2011-015) from the Seoul National University Bundang Hospital Research Fund.

Publisher's Note {#FPar7}
================

Springer Nature remains neutral with regard toInterchromosomal interactions and olfactory receptor choice.
The expression of a single odorant receptor (OR) gene from a large gene family in individual sensory neurons is an essential feature of the organization and function of the olfactory system. We have used chromosome conformation capture to demonstrate the specific association of an enhancer element, H, on chromosome 14 with multiple OR gene promoters on different chromosomes. DNA and RNA fluorescence in situ hybridization (FISH) experiments allow us to visualize the colocalization of the H enhancer with the single OR allele that is transcribed in a sensory neuron. In transgenic mice bearing additional H elements, sensory neurons that express OR pseudogenes also express a second functional receptor. These data suggest a model of receptor choice in which a single trans-acting enhancer element


with the three top players in each division competing in sudden-death heats on the ballroom's stage and playing on giant boards visible to all. The winner will walk away with the grand prize of $1,500 and an unabridged dictionary, to be awarded at the luncheon that follows. All participants, Shortz says, will come away with a refreshed, if not enlarged, mind.

Crosswords "lead you into every field of human knowledge," says Shortz, who began creating puzzles at age 9. "They never get boring, there's always something to learn. Absolutely anything can appear in a crossword puzzle."at the prestigious event hosted at the Sefako Makgatho Presidential Guesthouse in Pretoria. “We condemn such heinous acts of criminality, which should never again happen in our land. We are committed to respect the rights of all people within our borders, to strengthen the rule of law and to promote tolerance and understanding.” Ramaphosa said his government is working to address the specific social and economic factors that gave rise to “frustration and anger among some of our people”. He, however, emphasised that South Africans are not generally xenophobic. “For decades, South Africans have lived peacefully alongside people from other parts of the African continent and beyond – sharing resources, learning from one another and deepening our multiculturalism, including through marriage,” he said.

“We have a responsibility as leaders


CTTS that is dominated by accretion shocks in X-rays. Its X-ray spectrum shows high density plasma as evidenced by density sensitive lines in He-like triplets of oxygen and neon and an unusually cool plasma distribution [@kas02; @ste04]. TW Hya has been extensively studied in X-rays and a very deep [*Chandra*]{} observation suggests that the accreted and shock-heated material mixes with surrounding coronal material, likely producing a complex distribution of emission regions around the accretion spots [@bri10]. So far all low-mass CTTS studied at X-ray energies show similar signs of accretion plasma, classic examples are e.g. BP Tau [@schmitt05], V4046 Sgr [@guenther06; @arg12], MP Mus [@arg07] or RU Lup [@rob07b]. In contrast, T Tau itself shows a strong cool plasma component, but a low plasma density [@gue07a]; although the system is dominated by the intermediateweak outflow; while typically about 5–10% of the accretion rate are estimated, [@whi04] give a 2% upper limit derived from their data.

[lcr]{}\
Sp. type & M0$^{1,2,3}$ &\
$T_{\rm eff}$ & 3800$^{3}$ ... 3850$^{1}$ ... 3950$\pm 50$$^{4}$ & K\
$M_{*}$& 0.4$^{1,2}$ ... 0.5$^{3}$ ... 0.65$\pm 0.05$$^{4}$& $M_{\odot}$\
$R_{*}$& 1.9$\pm 0.2$$^{4}$ ... 2.1$^{2}$ & $R_{\odot}$\
$L_{\rm bol}$ & 0.8$\pm 0.2$$^{4}$ ... 0.9$^{2}$ ... 1.0$^{1}$ & $L_{\odot}$\
$A_{V}$ & 0.25$^{2}$ ... 0.5$^{1}$& mag\
$\log \dot{M}_{\rm acc}$ & -7.8$^{3}$ ... -8.5$^{2}$ ... -9.1$\pm 0.3$$^{4}$ & $M_{\odot} yr^{-1}$\

[$^{1}$ [@ken95], $^{2}$ [@gull98], $^{3}$ [@whi04],\
$^{4}$ [@donati13]]{}

Photometric variations of DN Tau’s optical brightness were first reported with a period of about $P_{\rm rot} \approx 6.0$ d [@bou86], later refined to $P_{\rm rot} = 6.3$ d [@vrba93]. This variability can be interpreted as rotational modulation of a large magnetic spot or spot group with a surface coverage


fit, both methods give $L_{\rm X} = 1.2 \times 10^{30}$ ergs$^{-1}$ and an average coronal temperature of about 12–14 MK. DN Tau is among the X-ray brighter CTTS, when compared to similar objects in the XEST or COUP sample and its X-ray activity level is with $\log L_{\rm X}/L_{\rm bol} \approx -3.5$ close to, but still about a factor of three below, the saturation limit at $\log L_{\rm X}/L_{\rm bol} \approx -3$. We re-observed DN Tau in 2010 with [*XMM-Newton*]{}, primarily to obtain a deeper exposed high-resolution X-ray spectrum with the aim to expand the sample of emission line studied CTTS into the lower mass regime.

In this paper we present an analysis of the new [*XMM-Newton*]{} observations of DN Tau and compare it to earlier observations. Our paper is structured as follows: inin the softer X-ray regime, whereas the spectra above 1 keV are virtually identical. The similar spectral slopes suggest that the changes at low energies are not caused by variable line-of-sight absorption, but are intrinsic to the emission of DN Tau.

The spectral properties of DN Tau and their changes between the two observations are quantified by modeling the spectra in iterative steps to obtain most robust results. We first investigate potential effects of the flares on the total 2010 spectrum, but found no differences between the models for the quasi-quiescent ($t < 55$ ks) and active half, except for small re-normalizations by a few percent. In a next step we fitted the total data of each observation individually. No significant changes in absorption column density and coronal abundances were found between the


year 2010. Correspondingly one would expect, assuming a similar corona, a comparable increase in the coolest plasma component and while there appears to be some deficit in total photons, this is roughly consistent with our finding from ($r$) and the EMD modelling.

A density analysis of hotter plasma at $\approx$ 4MK can be carried out with the triplet, that also has a higher critical density. Here we find a $f/i$-ratio that is compatible with its low density limit ($n_{e} \approx 1.0\times 10^{11}$cm$^{-3}$), while at the high end we can only put an upper limit of $n_{e} \lesssim 5 \times 10^{12}$cm$^{-3}$ on the plasma density. In addition, the $i$ line is blended by several Fe lines with being the strongest one; this is not taken into account in above calculation sincethe hottest part of the accreted and shocked material will reach X-ray temperatures, however this is still sufficient to produce detectable signatures in the X-ray data. Combining the only moderate mass accretion rate and the low impact velocity would explain, why the soft excess of DN Tau is even smaller than those of old CTTS like V4046 Sgr or MP Mus. While their accretion rates are even lower, these objects are more massive and especially more compact ($M_{*}/R_{*}$) and the accretion shocks have higher temperatures and produce X-ray emission in the -lines more efficiently.

Comparing DN Tau to other young stars in the lower mass regime, we find that a moderate soft excess is also present in the TWA member Hen 3-600 [@huene07], a multiple system with an M3/M3.5 binary as principle components. The


deliver a shipment of F-35 fighter jets unless Turkey drops its plans to buy a Russian missile-defence system. Turkey has detained a dozen or so Americans, and three Turkish employees at American consulates, as part of a broader crackdown in connection with the foiled coup.

This tangle of disputes means Mr Trump’s threats may backfire. “Ankara sees Brunson as leverage in a grand bargain that includes resolution of all their differences,” said Sinan Ulgen, a former diplomat who runs EDAM, a think-tank in Istanbul. For Mr Erdogan to free Mr Brunson now, he adds, would be “perceived as buckling to American extortion”.

Other Americans incarcerated in Turkey are even worse off than Mr Brunson, since they lack advocates in the White House. In 2016 Serkan Golge, a 38-year-old Turkish-American physicist  using (FileStream input = new FileStream(src, FileMode.Open, FileAccess.Read, FileShare.None, buffer.Length))
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In my form's event handler, i do update a progressbar with the received event args, this works fine when i run.
        progressBar1.Value = e.ProgressPercentage;

When i debug my app the progressbar value is updated normally but is not advanced in myWideman v.
Colorado, No. 09-1398, 2010 WL 2382459, at *2 (10th Cir. June 14, 2010)
(unpublished) (characterizing Mr. Wideman’s appellate arguments as “without
merit”); Wideman v. Colorado, 242 F. App’x *611, *614 (10th Cir. 2007)
(unpublished) (resolving appeal numbers 07-1152 and 07-1154, and observing
“that the majority of [Mr.] Wideman’s claims are little more than thinly disguised
efforts to overturn, or at least call into question the validity of, the rulings entered
against him by the Colorado state courts”).

                                          -2-
and parental responsibility to racially oppress the Plaintiff . . . in violation of his

Constitutional


No problem, and the light bulb icon you mean? That's actually a forum icon that i've put in via the forum's templates, you don't have a smiley in your title. But for the radiobutton icons, if you need to remove one of those, there's a small kind of concealed option on the left (I think it's just harder to see becauase usually we're looking for an empty radio button with the rest of the image icons on the right):KUCHING: HP’s latest HP Spectre x360 boasts an arena of leading tech features including the latest generation processors, longer battery life, and brilliant displays in a sleeker, more angular designs.

HP’s award-winning Spectre x360 laptop now offers the world’s longest battery life in a quad-core convertible without compromising on style and durability, while improving security with an integrated privacy screen option.

“HP is delivering the world’s thinnest touch laptops, while setting new industry standards for battery life, security and design,” said Kevin Frost, vice president and general manager, Consumer Personal Systems, HP Inc.

“The newest Spectre laptops further demonstrate how the company is finding new and exciting ways to drive momentum in the premium PC market.”

The redesigned HP Spectre x360 transforms between a laptop and a tablet while delivering quad-core performance,


or 4 decades or more
its just that they don't pay advisors fees or pander to tracking the "index"
why do you think a number of very rich families have used active funds? If its
good enough for Lord Rothschild its good enough for me.

~~~
henrikschroder
[http://en.wikipedia.org/wiki/Survivorship_bias](http://en.wikipedia.org/wiki/Survivorship_bias)

------
vilhelm_s
> In other words, if all of the managers of the 2,862 funds hadn’t bothered to
> try to pick stocks at all — if they had merely flipped coins — they would,
> as a group, probably have produced better numbers. Instead of two funds at
> the end of five years, basic probability theory tells us there should have
> been three.

Um. You are trying to tell me that 2 instead of 3 is enough to reject the null
hypothesis? I rather doubt it.

a \times ( f \circ \omega_b) = (f \circ \omega_b) \circ \omega_a = f \circ \omega_{ba} = ba \times f(x)$
These two actions are obviously not the same, but I can't seem to write my first action in the $\omega_g$ notation.
I am wondering whether the first action is really an action, or whether the notation is hiding something which makes it not an action. Moreover, how can it be written in the $\omega_g$ notation? I can fix the omega notation by mapping to $\omega_{g^{-1}}$, but paradoxically it doesn't seem to be associative if I use my first notation.

A:

Your "associative property" is incorrect. In fact, if $(g\ast f)(x):=f(g\cdot x)$ then
$$ (a\ast(b\ast f))(x)=(b\ast f)(a\cdot x)=f(b\cdot (a\cdot x)),$$
which is "backwards." Indeed if you define $h(x)=f(b\cdot x)=(b\ast f)(x)$ then
$$ (a\ast (b\ast f))(x)=(a\ast


in Metro Paris calling Adele “a little too fat, but she has a beautiful face.” He has apologized and said he’s a fan. But, who’s really going to believe it after all his year’s of negative comments against women?

Should we care about what one of the world’s most famous designers thinks? I say yes…and no.

Yes, because he’s crazy famous and has fashion influence beyond what we can imagine.
This gives him a platform which allows him to spread his ugly ugly words to the world.

No, because as Jacqueline commented on my Facebook page: “We’ve got to stop getting angry when we hear that word. It takes the lovely out of you when you allow stupid & foolish people to give negative meaning to it.” Makes sense. Besides, the 78-year-oldin exam (e.g., contact vs. reaction-diffusion dynamics) [@iannelli2018influencers], and on the timescale at which the dynamics is observed [@zhou2019fast]. The main takeaway from these studies is that there might exist no all-weather algorithms. The good performance of an algorithm in a given problem does not guarantee good performance in another problem, and even for the same problem, different problem specifications might require different algorithms. This uncertainty highlights the importance of reporting clearly the scenarios where an algorithm is effective, and the scenarios where the algorithm fails. In the problem of identifying the influential spreaders under a given spreading model, this can be achieved by reporting the algorithms’ performance over a broad range of values of the model parameters, and understanding which parameter ranges are the most relevant ones for various


their own games, which might be considered a form of cooperation. So when Roger Federer played Rafael Nadal, or when LeBron James played against Kobe Bryant, or when Greg Maddux pitched against Randy Johnson, they all relished this competition because they believed it raised the intensity and level of their own game. In essence, the competition served as positive motivation for these superstars to continually improve and refine their skills.

* * *

Reducing Competition Through Cooperation

Sherif and Sherif (1969) conducted three field experiments with 11- and 12-year-old boys in isolated camps. First, two groups were formed, and each was provided the opportunity to develop a strong group identity. Sports and games were a large part of the groups' activities, and teamwork and group identity were emphasized. In the nexthave successfully changed attendance at practice; have increased output by swimmers in practice (Koop & Martin, 1983); have improved fitness activities (Leith & Taylor, 1992) and gymnastics performance (Wolko, Hrycaiko, & Martin, 1993); have reduced errors in tennis, football, and gymnastics (Allison & Ayllon, 1980); and have improved golf performance (Simek, O'Brien, & Figlerski, 1994). Other programs have effectively used behavioral techniques to decrease off-task behaviors by figure skaters (Hume, Martin, Gonzalez, Cracklen, & Genthon, 1985) and to change or develop healthier attitudes toward good sporting behavior and team support (Galvan & Ward, 1998). Let's look closely at a few examples of successful behavioral
programs.

Feedback and Reinforcement in Football

In a classic study that provides a good first example, Komaki and Barnett (1977) used feedback and praise


mental challenges faced.
  * Complete absorption in the activity. The participant is so involved in the activity that nothing else seems to matter. A basketball player states, "The court—that's all that matters.... Sometimes I think of a problem, like fighting with my girlfriend, and I think that's nothing compared to the game. You can think about a problem all day but as soon as you get in the game, the hell with it.... When you're playing basketball, that's all that's on your mind."
  * Clear goals. Goals are so clearly set that the athlete knows exactly what to do. This clarity of intention facilitates concentration and attention. As one swimmer said of the flow experience, "I knew exactly how I was going to swim the race."
enhance cohesion in their teams or groups.

6. Identify guidelines for building team cohesion.

Researchers have recently developed and outlined interventions for both sport and exercise settings to enhance task and social cohesion. However, group members, as well as coaches or leaders, must assume responsibility for developing group cohesion.

Key Terms

cohesion

attractiveness of the group

means control

task cohesion

social cohesion

environmental factors

personal factors

leadership factors

team factors

sociogram

interactive sports

coactive sports

team-building

direction of causality

stability

Review Questions

1. Discuss the definitions of cohesion, including the difference between task and social cohesion.

2. Discuss how measuring cohesion has developed via questionnaires.

3. Findings in the research literature on the cohesion–performance relationship have been inconsistent. Explain if or how the types of instruments used to measure these two factors and the demands of the task have affected this relationship.

4. Does cohesion lead to winning, or does winning


hypothesized four critical constructs in their 4C model defining mental toughness.

  * Control—capacity to feel and act as if one could exert an influence in the situation in question
  * Commitment—tendency to take an active role in events
  * Challenge—perception of change as an opportunity to grow and develop rather than as a threat
  * Confidence—strong sense of self-belief

More recently, Gucciardi, Gordon, and Dimmock (2008, 2009a) developed a scale to measure mental toughness and focused on the situations requiring mental toughness. These include

  * injury and rehabilitation,
  * physical and mental preparation for competition (work ethic),
  * balancing commitments (relationships, work, media),
  * peer and social pressure (drinking, drugs, late nights),
  * difficult environmental and playing conditions (e.g., weather,the most effective type of goal setting for gymnasts depended on their locus of control. That is, for gymnasts who had an internal locus of control, setting their own goals was most effective, whereas for gymnasts with an external locus of control, coach-set goals were most effective. Goal perspective (see chapter 3) is another important individual-difference factor to take into consideration when setting goals, because being more task oriented or ego oriented will affect the type of goals (i.e., process, performance, outcome) to be used.

Not Providing Follow-Up and Evaluation

A problem that teachers, coaches, and exercise leaders have too frequently is setting goals at the start of a season and then not using them effectively throughout the season or year. A lack of follow-up and evaluation is one of


programs, we need to consider the interests of the particular people involved if we are to overcome the 50% dropout rate that has plagued us for more than 30 years.

Guidelines for Improving Exercise Adherence

Several elements have emerged as keys to enhancing adherence to exercise. We'll consolidate these elements now into guidelines for the aspiring fitness professional.

  Match the intervention to the stage of change of the participant.

  Provide cues for exercises (signs, posters, cartoons).

  Make the exercises enjoyable.

  Tailor the intensity, duration, and frequency of the exercises.

  Promote exercising with a group or friend.

  Have participants sign a contract or statement of intent to comply with the exercise program.

  Offer a choice of activities.

  Provide rewards for attendance and participation.

217–224.

Lirgg, C.D., & Feltz, D.L. (1994). Relationship of individual and collective efficacy to team performance. _Journal of Sport and Exercise Psychology, 16_ (Suppl.), S17.

Lirgg, C.D., & Feltz, D.L. (2001). Self-efficacy beliefs of athletes, teams, and coaches. In R. Singer, H. Hausenblas, & C. Janelle (Eds.). _Handbook of sport psychology_ (2nd ed. pp. 340-361). New York: Wiley.

Little, D.E., & Watkins, M.N. (2004). Exploring variation in recreation activity leaders' experiences of leading. _Journal of Park and Recreation Administration, 22,_ 75–95.

Locke, E.A. (1968). Toward a theory of task motivation incentives. _Organizational Behavior and Human Performance, 3,_ 157–189.

Locke, E.A., & Latham, G.P. (1990). _A theory of goal setting and task performance._ Englewood Cliffs, NJ: Prentice Hall.

Locke, E.A., & Latham, G.P. (2002). Building a practically useful theory of goal setting and task motivation:


Illustrated,_ pp. 54–60.

Swift, E.M. (1999, July 5). Drug pedaling. _Sports Illustrated,_ pp. 60–65.

Swoap, R.A., & Murphy, S.M. (1995). Eating disorders and weight management in athletics. In S.M. Murphy (Ed.), _Psychological inter_  _ventions in sport_ (pp. 307–329). Champaign, IL: Human Kinetics.

Syer, J. (1986). _Team spirit._ London: Simon & Schuster.

Tarshis, B. (1977). _Tennis and the mind._ New York: Tennis Magazine.

Tatum, J., & Kushner, B. (1980). _They call me assassin._ New York: Avon.

Tauer, J.M., & Harackiewicz, J.M. (1999). Winning isn't everything: Competition, achievement orientation, and intrinsic motivation. _Journal of Experimental Social Psychology, 35,_ 209–238.

Taylor, A.H. (2001). Physical activity, anxiety, and stress. In S.J.H. Biddle, K.R. Fox, & S.H. Boutcher (Eds.), _Physical activity and psychological well-being_ (pp. 10–45). London: Routledge & Kegan Paul.

Taylor, A.H., Daniel, J.V., Leith, L., & Burke, R.J.set of 2D images or a 3D volume. The 2D approach showed to be a good balance between the moderate performance of the 1D model and the cost of the 3D model because of the 3D convolutions. In the radial basis function, the value of $\alpha$ was set to $0.01$.

The cross-entropy is used as the cost function. The numerical optimization was performed with SGD, with an initial learning rate $lr_0 = 1e-3$ and a momentum of 0.9. As in [@DBLP:journals/corr/ChenPK0Y16] the learning rate was updated at each epoch with the poly rate policy: $$poly(iter) = lr_{0} *\left(1-\frac{iter}{max_{iter}}\right)^{power}$$ Where $iter$ is the index of the epoch, $max_{iter}$ the maximum number of epochs and $power=0.9$. Batch of size 256 gave the best results. ReLU is the default activation function. Our


 0.452 $\pm$ 0.36   66.02 $\pm$ 40.19
  distance + conv          0.720 $\pm$ 0.14   10.09 $\pm$ 5.41
  distance + conv + rbf    0.718 $\pm$ 0.17   10.42 $\pm$ 5.82

  : Comparison of methods to integrate distance to landmarks, performance measured using the dice similarity and the Hausdorff distance. (average $\pm$ standard deviation)[]{data-label="tab:distance"}

Figure \[segmaps\] shows an example of segmentation maps we produced with the tested models. A real performance gap can be noticed between BaseNet(e) and BaseNet+DistBranch (d), where the first detects background between the left and right lateral ventricles and the second is able to recover smooth structures.

In table \[tab:results\], we can notice the impact of each branch inQ:

Display HTML with qTip2

I've created a minimized sponsor section with small (50x50 sized) thumbnails through the List Category Posts WordPress plug-in on my site (can be seen here). This plug-in simply displays posts from certain categories anywhere on your website.
I now want to add a tooltip on hovering the image, which would essentially display the posts the_content();. For the tooltip I'd be using qTip2, since this seems to be the best tooltip solution.
My problem occour, when nothing happens on hovering. Can you spot the error? I've been battling this problem for 3 straight days now.
When looking at the HTML, think as if, you couldn't modify it. The code can be found on JSFIDDLE (I hope the code is valid, but I'm not sure, since this is the first


Q:

HTML underline button

Hi there I am working on making a word processor, and need to make a button to underline the text in the text area. I have made one button that makes the text italic but unsure on the underline button. Any help would be appreciated
<textarea rows="10" cols="100" id="myP" >
      Type text here...
</textarea>

<button type="button" onclick="myFunction()">Set font Italic</button>

A:

Change the textDecoration property from the style object which, in turn, will modify the text-decoration CSS style:
function underline_text(){
    document.getElementById("myP").style.textDecoration = "underline";
}

JSFiddle

A:

Here's a solution:
<button type="button" onclick="myFunction2()">underline</button>

Thanks for the info on the recruiting expo.  Sounds like fun, but I won't be
able to make it.  I am taking the day off on Friday, April 13th to take
Meagan for her info session and tour at UT.  We will be driving to Austin
after she gets out of school on Thursday afternoon, April 12.

You know that you can count me in already as a team member!  --Sally

	Enron North America Corp.

	From:  Lexi Elliott @ ENRON                           04/04/2001 03:44 PM

To: Richard Causey/Corp/Enron@ENRON, Mark E Lindsey/GPGFIN/Enron@ENRON, Sally
Beck/HOU/ECT@ECT, Craig Breslau/HOU/ECT@ECT, Cedric Burgher/Enron@EnronXGate,


as the professionals from the CWL and how that’s a major focus when developing Black Ops 4’s competitive offering.

“We’ve had ranked play in our last few games, and it’s usually for a certain very passionate segment of players that are really good. They follow the professionals in esports and they want to play the same game that the people they look up to are playing. The pro players, you can see their following on social media. They have hundreds of thousands of players following them. There’s a lot of people interested in that.”

Read the full interview over at GamesBeat to learn more about Treyarch’s philosophy behind rewarding the top percentile without punishing the bottom 50% of players.years, the changes have been minimal. And in some ways they’ve perhaps even degraded.

The technology itself, however, wasn’t the only problem:

iBeacon was a trademark for beacons, but Apple offered little value in the iBeacon brand. You could adopt the iBeacon mark – or not. There was little incentive for beacon manufacturers to proudly wave the iBeacon flag, because it offered little assurance to end purchasers. Sure, it said that “this beacon can be heard by iPhones” but this caused more of a limitation than an opportunity – because the obvious next question was “What about Android?”

Apple lawyers got in the way. The company aggressively protected its ‘iBeacon specification’. But the move was kind of like trying to protect a proprietary version of WiFi – it’s a technology everyone


Absolute frequency measurement of the In+ clock transition with a mode-locked laser.
The absolute frequency of the In(+) 5s(2) (1)S(0)5s5p (3)P(0) clock transition at 237 nm was measured with an accuracy of 1.8 parts in 10(13). Using a phase-coherent frequency chain, we compared the (1)S(0)(3)P(0) transition with a methane-stabilized HeNe laser at 3.39 microm, which was calibrated against an atomic cesium fountain clock. A frequency gap of 37 THz at the fourth harmonic of the HeNe standard was bridged by a frequency comb generated by a mode-locked femtosecond laser. The frequency of the In(+) clock transition was found to be 1,267,402,452,899.92 (0.23) kHz, the accuracy being limited by the uncertainty of the HeNe laser reference. This result represents an improvement in accuracy of more than 2 orders of magnitudeNonalcoholic fatty liver disease and carotid artery atherosclerosis in children and adults: a meta-analysis.
Observational studies suggest that nonalcoholic fatty liver disease (NAFLD) is associated with increased carotid intimal medial thickness (C-IMT) and carotid plaques in both children and adults. We carried out a meta-analysis to evaluate the relationship between NAFLD and carotid atherosclerosis measured as C-IMT and carotid plaque prevalence. Medline (Ovid), PubMed, Web of Science, and CINAHL databases were searched from 1946 to September 2014, complemented with a manual review of references of the published articles for studies that compared C-IMT or carotid plaque prevalence in adults and children. Results were pooled using both fixed and random effects models. Of the studies identified, 20 were suitable for testing the effect of NAFLD on C-IMT in adults, 13


to see four small children using Oum's body as a playground.

A red-haired midget tumbled onto Oum's lap, only to climb up his right arm and repeat the action endlessly. Meanwhile, a dark-haired girl lay still on his head as she slept quietly, while a snowy heiress was chasing after a blonde brawler that stole a piece of her cookie.

Oum sat still, with four tiny things using his body as if it were a jungle gym.

He had called her up to apparently inform her of something, and now, she sort of understood why he called with such a serious tone.

"…"

"…"

The silent squeals of two hyperactive sisters and the cries of one angry Schnee were the only sounds that filled the room.

Soon, the Huntresses seemed to notice Sheena, for theyIn order to relate the transition moments to oscillator strengths, excitation energies need to be evaluated. The excitation energies are obtained from the Fock-space multi-reference framework. The transition dipole moments of the ground to a few excited states, together with the oscillator strengths of a few molecules, are presented.


ULTIMATE MARVEL VS. CAPCOM 3

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Harry Redknapp will remain as manager of Queens Park Rangers despite the club's relegation from Premier League.

QPR's fate was confirmed after Sunday's 0-0 draw with Reading.

"I don't think there was a point where he was thinking of not being with us and continuing this project he has embarked upon," club co-owner Fernandes said after a meeting with Redknapp. external-link

19% - Harry Redknapp has the lowest win percentage of any QPR manager in the Premier League. Neil Warnock 20%, Mark Hughes 20%, Gerry Francis 37%, Ray Wilkins 39%. More on QPR's relegation in numbers

"Harry will not be forced to sell any players he wants to keep. We had a very good discussion on this."

Redknapp said leaving QPR had not crossed his mind despite


the envelope blank before the latter is heated. Then the open end portion of the envelope blank is heated to a moldable state, as by burners, while the envelope blank is being revolved about its own axis. As the envelope blank is thus heated, so are, of course, the amount assembly and the exhaust/supply tube inserted therein. Then the viscid end portion of the envelope blank is pinched to form the pinch seal fused to the exhaust/supply tube and also having the lead wires of the mount assembly embedded therein.
We object, in this conventional practice, to the simultaneous heating of the envelope blank and the exhaust/supply tube inserted therein. Heated to a viscid state with the envelope blank, the exhaust/supply tube has been susceptible to deformation upon pinch-sealingThe primary aim of this book is to provide a guide to current practice and equipment for non-specialist surveyors in the various professions involved in the construction industry and the environment. It is suitable for students preparing for degrees The primary aim of this book is to provide a guide to current practice and equipment for non-specialist surveyors in the various professions involved in the construction industry and the environment. It is suitable for students preparing for degrees and diplomas in architecture, building, building surveying, quantity surveying, estate management and town planning and environmental studies. It is also of value to engineers who are not specialising in engineering surveying.

This book has been thoroughly revised to include new topics such as OS digital mapping, standard deviation and standard error,


larger threshold at vessel pixels near the related centreline of the retina vessels affected by the central light reflex. We manually select the thresholds and calculate the ideal segments of the central light reflex vessels. The final segmentation is the superposition of the segmentation from the extracted enhanced image, as shown in [Fig. 5(B)](#pone-0095943-g005){ref-type="fig"} and binarisation via entropy shown [Fig. 6](#pone-0095943-g006){ref-type="fig"} (A), where the effect of the central light reflex, indicated by green arrows in [Fig. 5(B)](#pone-0095943-g005){ref-type="fig"}, has been removed in the resultant image, as shown in [Fig. 6](#pone-0095943-g006){ref-type="fig"} (B). We name this the dual-threshold entropy approach, to position it in the overall taxonomy of retina vessel segmentation methods, e.g. [@pone.0095943-Fraz1].

![Outputs of interim processing steps.\
(A) Illustration of binarisation with threshold selected to maximise entropy. (B) Illustration of thefinal segmentation, where the effect of central light reflex, indicated by green arrows in Fig. 5(B) has been removed in the resultant image.](pone.0095943.g006){#pone-0095943-g006}

To achieve clear segmentation of blood vessels in the images of the retina, we conduct simple morphology post-processing, i.e. morphological connectivity constraint operations on the extracted curvature based enhanced images. The connectivity constraint is varied according to different background texture of noise that dominates the image. The fine-grained noise texture (small contiguous bright region) determines small connectivity constraint, and vice versa for coarse-grained noise texture (relatively large contiguous bright region). The morphological spectral clustering is applied for the identification of textural regions. This is to consider the fact that texture appearance is changing with image recording parameters, for instance, illumination variation and direction of view, a


are linearly combined to produce the whole segmentation for the curvature based enhanced image. A similar method is used for a retinal image with pathological tissue, which will be differentiated into two parts with and without the pathology. The criteria to merge these segments into two are as follows. If the illumination is non-uniform, the segment with noise can be divided into two parts: (i) a segment with fine-grained noise texture and (ii) a segment with coarse-grained noise texture. The texture of noise is associated with the size of much smaller contiguous bright regions from the background after segmentation, which is different from retinal vessels that contain larger contiguous regions of bright pixels. The two portions in relation to two different textures of noise lead to two differentthe pixels found to be vessels by our proposed algorithm (this means they are false positives) and the green colour indicates vessel pixels in the gold standard segmentation (this means they are false negatives). The [Fig. 7(D)](#pone-0095943-g007){ref-type="fig"} shows good overlapping between the two segmentations with slight errors.

[Fig. 11](#pone-0095943-g011){ref-type="fig"} and [Fig. 12](#pone-0095943-g012){ref-type="fig"} show the effect of images containing pathological tissues, corresponding to images 03_test and 08_test from DRIVE database, respectively. Their green channel-only images are shown in [Fig. 11(A)](#pone-0095943-g011){ref-type="fig"} and [Fig. 12(A)](#pone-0095943-g012){ref-type="fig"}. The extracted enhanced image associated with the original image of 03_test after a global threshold and a global connectivity constraint is shown in [Fig. 11(C)](#pone-0095943-g011){ref-type="fig"}. It has been split into two parts according to the colour coded mapping shown in [Fig. 11(B)](#pone-0095943-g011){ref-type="fig"}. The part in relation to


Sets (IS) containing full fundus images: high-resolution (HRIS), central light reflex (CLRIS) and vascular disease (VDIS) with each set containing representative images that are particularly large, show visible pathologies and have vessels exhibiting prominent central light reflexes, respectively. A fourth set, the kick-point image set (KPIS), contains downsampled high-resolution images of several large diameter non-tortuous vessels. The database also offers manual width measurements made by three independent observers using a custom software tool for marking vessel edge points, so that the ground truth edge points are considered to be the average of the measurement made by the three observers at the same location in a vessel segment. A total of around 2000 locations are available for vessel width analysis.

Considering the similarity between the vessel widths in ground truthmanually delineated edge points and the width measured entirely by our algorithm, width measurement accuracy cannot readily be quantified. The edge image produced by our method will differ from the manual edge detection, which will cause measurement locations and angles to not match up. One way, however, results in good agreement with the manually delineated vessels by overlaying the vessel edge points calculated from our algorithm located on top of the manually segmented images. In order to achieve the manually segmented images, we conduct a morphological close operation on the ground truth points with structuring elements of size and this closed version is used as the ground truth segments. The closed versions of the manually delineated edges are obtained with variable , only if at this value, all


(E) and (F) Illustration of centreline of (C) and (D). (G) The error image of difference between (C) and (D). (H) Colour coded lines between each pair of ground truth coordinates.](pone.0095943.g015){#pone-0095943-g015}

![Extraction of the error image in the region that the error image is overlapped with the straight line based image of Fig. 15(H).](pone.0095943.g016){#pone-0095943-g016}

The performance of the proposed edge detection method is evaluated based on four retina images, related to the image sets: HRIS, CLRIS, VDIS, KPIS. The HRIS image sets are downsampled by a factor of four before being input into the test algorithms, and it is these downsampled measurements that are reported in the REVIEW database. Since manual measurements are made on the original images, vessel widths are considered to be known to an accuracy of pixelsranging from the IFC performance standards to the voluntary principles on security and human rights, to the calls for corporate accountability laws by Supreme Court Justice Ian Binnie, to the meticulous work by John Ruggie, special representative of the Secretary General on human rights and transnational corporations.

If you look at these things, you see a consistent pattern of an increasing articulation of what is expected from companies these days, and nowhere is this truer than in Canada. Bill C-300 lands smack dab in the middle of all this.

These are the four differences I think Bill C-300 can make, and these differences are all positive differences for companies, in my view. First, I think it could help clear the air for our most honourable companies. The fusion of NGOs


company from a Chinese company is that a Canadian company has a competitive advantage when it comes to safety, social issues, respect for human rights, community engagement, contribution to local employment, and environmental protections.

Bill C-300 is not perfect, nor is it enough, but by making a move to a credible accountability mechanism, it sends a strong signal that Canadian companies will be on the winning side of the seismic shifts shaping our global economy.are maintained separately instead of combined after the transformation. The ray could span total 360 degree when circular geometry is used. An advantage of this approach is elimination of the work necessary to extract the line parameters (e.g. direction data) in the transformed domain that often is impossible with the traditional approach. The advantage of the modified Radon Transform method is amplified when many lines are present in the imagery or when the lines are just short segments which both occur in actual imagery.


A federal immigration judge ruled Tuesday that President Obama’s uncle can remain in the United States, sparing him deportation to his native Kenya in a case that riveted attention on the elderly man who had lived under the radar in this country for 50 years. For most of that time, he was here illegally.

Boston immigration Judge Leonard I. Shapiro said Onyango “Omar” Obama can now get a green card, and in five years, apply for US citizenship, unless the Department of Homeland Security appeals the case within 30 days.

“Congratulations,” Shapiro said after he announced his decision. “Welcome to America.”

The case stirred controversy because the president’s uncle was arrested in 2011 for drunken driving in Framingham and was found to have an outstanding deportation order from 1992. Many accusedLuke Wilson made his feature acting debut as the lead of Bottle Rocket, the quirky 1996 comedy that simultaneously introduced the world to writer/director Wes Anderson and co-writer/co-star Owen Wilson. Luke quickly moved onto more mainstream fare and in the eleven years since his first performance, he has maintained a presence as one of the more likable though low-key men in big screen comedy. While box office numbers have repeatedly proven that people won't flock to theaters just to see him, Wilson has done well on three fronts: collaborating with his Texan pal the time-taking auteur Anderson (The Royal Tenenbaums); reveling as part of Hollywood's so-called Frat Pack,

a troupe that includes older brother Owen, Vince Vaughn, and Will Ferrell; and appearing in the occasional hit away from familiar


wanted the next season to hurry up and arrive. I will not fall down to the qualifiers ever again. I hope people will keep watching me.I think it’s because I am lacking in skill. Even people around me ask me why I’m in the qualifiers. When I look back on it, I think I was lacking in preparation last season. So I want to advance far for this season.For now, I want to break my quarter-finals jinx rather than aim for the championship since I have never gone to the quarter-finals before for GSL.Since groups are now picked through a lottery system, I think I’ll be able to humbly accept whatever group I get placed in as long as I stay calm.The problem with Terran is that ourA former Chelsea youth player has alleged that Gwyn Williams presided over a “mini apartheid state” there and may join a group of former members of the junior setup seeking to take legal action against the club.

The player, who wishes to remain anonymous, was prompted to explore legal action after reading in the Guardian about the experiences of other former Chelsea youth players.

Amid mounting allegations of abuse, denied by Williams, Chelsea have brought in Barnardo’s, Britain’s largest children’s charity, to oversee an independent investigation.

It is understood more players are set to come forward to allege racial abuse in the 1980s and 1990s. The latest player to speak out said he decided to go public after reading the accounts of Grant Lunn and Gary Baker, two white men who


to enter at other times so they could perhaps be employed as a cleaner or merely allowed to attend other types of activities that may be taking place.

"The Cabinet Secretary for Justice agreed in front of the Local Government and Regeneration Committee last week that we would look at the issue further and bring forward an amendment to tighten up the rules further for Stage 3 of the Bill."at the time the events set forth above occurred the defendant appeared slightly intoxicated but had no odor of alcohol on his breath.
 In the proceeding pending in the respondent court, the defendant is charged with a violation of Health and Safety Code section 11530, possession of marijuana, a felony, and a violation of Health and Safety Code section 11910, possession of dangerous drugs, a misdemeanor. In granting the defendant's motion to suppress, the lower court rooted its holding in two propositions; first, that the police officer had no right to ask the defendant what was in his right rear pocket and second, that the police officer had no right to open the cigarette for examination. In support of the respondent's action, defendant contends that the opening of