12 district crowns. Gilmer turned in a pair of perfect 16-0 seasons, won 10-or-more games 11 times, and registered seven 13-win seasons and three 15-win campaigns during his tenure. In 2014, Gilmer renamed Buckeye Stadium to Jeff Traylor Stadium to honor Traylor’s success

read more here

To those who didn’t watch the announcement presser, I know what your thinking. “here we go again, another SEC running backs coach, known for his recruiting, and seems to care a lot about building a positive player culture.” Trust me, as a person who had the opportunity to talk to Coach Wilson on many occasions, I can honestly say, these two men are not the same.

When you shake Coach Traylor’s hand he’ll ask you for your name, repeat it, and say it’s nice totalked to us like we were old friends, not fans he was trying to win over. The whole time he looked at us in the eye and laughed with us and only checked his watch when the Cowboys scored. After our whole interaction Austin, one of the Bad Birds, noted that he stayed for the entire game and talked to every fan he could in the same way he talked to us. In talking to this man for a few brief minutes I understand why recruits gravitate toward him the way they do, I was ready to walk on the team myself. Coach Traylor is one of those people that just makes you want to go. He’s a football guy, who speaks in metaphors and war stories. Coach


using Biodiagnostic kits (Bio diagnostics Co., Egypt).

For hepatic, cardiac and renal tissues; the histopathological examination was carried out, tissue slices were fixed in 10% formaldehyde and embedded in paraffin wax blocks. Sections of 5 μm thick were stained with hematoxylin and eosin (H&E) then examined under a light microscope for determination of pathological changes.

2.5. Hematological parameters {#sec0035}
-----------------------------

Erythrocytes count, hemoglobin (Hb) levels and hematocrit (PCVt) were determined immediately in blood samples \[[@bib0045]\]. White blood cell (WBC) count was determined as described by Schaperclaus et al. \[[@bib0050]\].

2.6. Biochemical parameters {#sec0040}
---------------------------

Liver function enzyme activities, alanine and aspartate aminotransferases (AST and ALT), as well as alkaline phosphatase (ALP), were estimated in mice and rat sera \[\[[@bib0055]\] \[[@bib0060]\], respectively\]. The levels of total urea and creatinine were determined according to the methods of Bartlescytokines, such as interleukin (IL)-6. High serum levels of IL-6 have been linked to risks for several conditions, such as cardiovascular disease, type 2 diabetes, mental health complications, and some cancers. This overview will discuss the evidence that psychological stress promotes immune dysfunction that negatively impacts human health.


Optical properties of aggregate particles whose outer diameter is comparable to the wavelength.
I describe results of numerical calculations of the optical properties (extinction efficiency, single-scattering albedo, phase function, and linear polarization) of aggregate particles whose outer diameter is comparable with the wavelength. Results are presented for two types of particle, one composed of monomers whose radius is small compared with the wavelength and a second containing monomers with larger radii. The shape of the forward-scattered lobe of the phase function is diagnostic of the mean projected area (but differs from that for an equal-area sphere), while the linear polarization, phase function at large scattering angles, and single-scattering albedo depend on the monomer diameter. The wavelength dependence of the extinction efficiency differs markedly from that for equal-area spheres. TheseTongnooma Group

Ms. SOMPASSEKDE represents the group TONGNOOMA. She is a married mother of one child, aged 4 years old. He does not go to school. Ms. SOMPASSEKDE has three persons to support. She has been selling 'pagnes' (the colorful cloth of western Africa) and ready-to-wear clothing for four years. She gets her supplies at the market in her sector. Her customers include both men and women. She wants to purchase a bale of 'pagne' cloth. She wants to reinvest her profits to expand her business sector. Her ambition is to improve her family's living conditions.

Additional Information

About Micro Start/AFD

This loan is administered by Micro Start/AFD, Kiva’s first Field Partner in Burkina Faso. Micro Start/AFD’s mission is to improve families' living conditions in general, and those of women in particular,


used for non-dance events, such as the Tribeca Film Festival, which takes place each spring.

Funding details for the project have yet to be worked out, and construction cannot start because the site will be occupied until then by a temporary exit from the PATH train. The city plans to work with the state and other parties to develop a plan for the site, with an ideal total price tag of less than $500 million. Original estimates for the center's costs were about $700 million.

In June 2004, the Lower Manhattan Development Corporation (LMDC) and its city and state partners offered space on the site to the Joyce along with three other cultural institutions - the International Freedom Center (IFC), the Signature Theatre, and the Drawing Center. In August 2005,Control beliefs as a mediator of the relation between stress and depressive symptoms among inner-city adolescents.
Adolescents' control beliefs were examined as a mediator of the relation between stress and depressive symptoms among a diverse sample of 445 inner-city adolescents. Results indicated that control beliefs significantly mediate the relation between stress and depressive symptoms. The specific direct effects of six individual stress domains (peer, family, school, neighborhood, economic, discrimination) on control beliefs and depressive symptoms were also examined. Results showed that (1) economic stress relates to adolescents' control beliefs, (2) family stress relates to adolescent depressive symptoms, and (3) peer stress relates to both control beliefs and depressive symptoms. Secondary analyses revealed that control beliefs significantly mediate the specific relations between peer stress and depressive symptoms. Results were not


Sea of Japan and are instead flying close to the Japanese archipelago as they approach Japanese airports from Europe.

That precautionary measure was taken in response to the launch by North Korea of a series of short, medium and long-range missiles, including two long-range tests in July that were identified as Pyongyang’s first successful ICBM launches.

North Korea has subsequently fired two long-range missiles directly over northern Japan.

The airlines said the route changes were “purely precautionary” and would only “minimally lengthen” flight times.funding. A nation coming out of recession provides a challenging environment in which to solicit funds. Cuts to education by state governments and a recession-battered private sector with less money available to provide grants and you have a sector that should be searching the ends of the earth for new funding sources.

Tradition, meet the 21st century. Academic researchers have started to embrace crowdfunding as an additional funding method to complement grant applications. Historically, the researcher expends much effort in tracking down foundations and other sources of grants, spends dozens of hours per submission and then enters into a competition with an indeterminate number of competitors for a finite amount of funds. Available pools of money can never hope to satiate the demand of worthy research.

Crowdfunding gives an additional


advantages crowdfunding has over traditional methods.

What is the crowdfunding experience like from the researcher’s perspective? I contacted the people behind three successful Microryza projects to get their impressions of the process.

Bergen McMurray and Katriona Guthrie-Honea are Co-Directors of DIYbio, whose mandate is to “demystify science through education”, DIYbio offers classes that open up the world of science to those who may not have been exposed to it. They also offer financial assistance to enable all to participate. An intern at the Fred Hutchinson Cancer Research Center in Seattle, Katriona attends high school in the Seattle area, while Bergen is a neuroscience student and past researcher at the Allen Institute for Brain Science and Jigsaw Renaissance. They secured $5,000 funding for DIYbio.

Lydia Chilton is a PhD student in computerhas written more than 2,000 original articles on the blockchain, peer-to-peer lending, crowdfunding and emerging technologies over the past seven years, making him one of the senior writers in the alt-fi sector.

"The evolution of the crowdfunding and peer-to-peer lending scenes is absolutely fascinating to chronicle. It is a joy to be around people with such passion and vision."

2 Comments

Sure ! the next generation education will have a great impact from the crowd funding. Following is one campaign that’s launched on Indiegogo (igg.me/at/edsprout) to create resources for entrepreneurship.

Sure ! the next generation education will have a great impact from the crowd funding. Following is one campaign that’s launched on Indiegogo (igg.me/at/edsprout) to create resources for entrepreneurship.


 Accordingly, this motion is denied.

8
Pursuant to Title 8 U.S.C., § 1105a, petitioner timely filed a petition for review by this court of that order of the Board.

9
This court has jurisdiction to review the denial of a motion to reopen deportation proceedings.  Giova v. Rosenberg, 379 U.S. 18, 85 S.Ct. 156, 13 L.Ed.2d 90 (1964).  The proper inquiry on review by this court is whether the denial of the motion to reopen was an abuse of discretion.  Velasquez Espinosa v. Immigration & Naturalization Service, 404 F.2d 544 (9th Cir. 1968).

10
Applications for suspension of deportation under § 244(a)(1) of the Act are normally required to be filed as a part of the initial deportation proceedings before the immigration judge and are foreclosed if not brought atand brother of the petitioner are permanent residents living in Los Angeles.  One sister, although not a permanent resident, is also living in Los Angeles.  Two sisters and one brother, who are citizens of the United States, are residing in other cities in California.  The application further reveals that petitioner and her husband are both employed in California and that the children were five years, four months old and one year, two months old at the time of the Board's order.  There is a strong inference of hardship to petitioner and her children from the fact situation itself.

16
It is the contention of the Immigration and Naturalization Service that the petitioner failed to provide sufficient evidence that the deportation would result in extreme hardship to


was fully explained to him and an opportunity to apply therefor was afforded him at the former hearing unless the relief is sought on the basis of circumstances which have arisen subsequent to the hearing.  . . .

4
 In Matter of Lam, supra, cited by the Board, the alien petitioner's allegation of extreme hardship consisted in substance only of the economic hardship which would be suffered by his inability to find an equivalent job in Hong Kong, where he was being sent.  In the other case cited by the Board Matter of Sipus, supra, the petitioner was a domestic employed in the United States, but her husband and children all lived in the Philippines where he was employed.  Her only contention of hardship was theMatrix Powertag

is a UCI Continental cycling team based in Japan. It was founded in 2006. For the 2014 season, the team added several riders from Spain, including Eduard Prades for the last part of the season. Masahiro Yasuhara is currently the manager of the team.

Team roster

 (trainee)

Major wins

2007
Stage 2 Tour of Thailand, Masahiko Mifune
2011
Stage 2 Tour de Hokkaido, Takahiro Yamashita
2012
Stage 2 Tour of Malopolska, Mariusz Wiesiak
2014
Stage 5 Tour of Thailand, Sebastián Mora
2015
Stage 2 Tour de Ijen, Benjamin Prades
Stage 4 Tour of Japan, Benjamin Prades
Overall Tour de Kumano, Benjamin Prades
Stage 2, Benjamin Prades
2017
Overall Tour de Kumano, José Vicente Toribio
Young rider classification Kenji Takubo
Tour de Okinawa, Junya Sano
2018
Stage 3 Tour de Kumano, Junya Sano
2019
Points classification Vuelta al Tachira en Bicicleta, Orluis Aular
Stage 3, Orluis Aular
Overall Ronda Pilipinas, Francisco Mancebo
Stage 1,


Search

€-Vision

There is an old Irish joke about a man who is lost and asks a local the way to a small village. The local pauses and answers: if I wanted to go there I surely wouldn’t start from here. Something similar applies to the European labour market. The news on joblessness in Europe has seemed so bleak for so long that it might seem hard to find a good word to say about it. But consider the following.

The EU labour market turned in May of 2013. Since then unemployment, seasonally adjusted, has fallen month for month, continuously in the EU28 and with a few brief intermittent spikes in the Euro Area, too. Over the more than three and a half years of expansion unemployment has fallen by 5¾should be protected from her'

Neither of the two victims were present in the courtroom Friday. An attorney for the boy who was molested read a statement from his mother.

"Before, he was an innocent child, and now she stole his innocence from him," the victim impact statement submitted to the court read. "I hate Brittany Zamora for what she did to my son and family. We should not suffer for someone else's sick pleasure, but we all are."

The parents of both boys had expressed concern that Zamora would get a lighter sentence because she is a young and attractive woman. The parents of the boy who was abused asked for the maximum sentence.

"Now you'll spend the rest of your youth and most of your adulthood in jail," the boy's


father wrote in a statement his attorney read in court to Zamora. "My son will grow up, have a good life, get married and have children of his own. I will not allow you to interfere in my son's life further. Good triumphs over evil."

Zamora's 20-year sentence was what her attorneys and family asked for. Her attorney highlighted Zamora's lack of criminal record and a psycho-sexual evaluation that determined she had no sexual interest in children, but suffered from anxiety and depression.

Zamora's mother Darlene Irwin told the court she thought it was actually the media and the public who were the monsters in this case. She said media coverage made Zamora seem more predatory than she was.

"Please understand this is not a monster. This is a beautiful personimmigration.

However, she was criticised for wearing the controversial jacket on her way to the centre and during her return trip, although she took off the jacket before arriving at the centre itself.

There was widespread speculation and criticism over what message Mrs Trump intended to send by wearing the jacket on that particular trip - although her spokeswoman said "there was no hidden message".

However, in an interview with ABC news that was released on Saturday, the former model acknowledged the jacket "was a kind of message, yes".

"It's obvious I didn't wear the jacket for the children, I wore the jacket to go on the plane and off the plane," she said.

"It was for the people and for the left-wing media who are criticising me. I want to show them


is known about a skipper, red eyes usually indicate that it is crepuscular.

Finally, the skipper’s posture and combination of colors resulted in a really beautiful photo- one of those rare pics that I knew would be awesome as soon as the shutter clicked.translated into English for the first time and published as a Penguin Modern Classic.

Lauded as one of the 20th Century’s most acclaimed works of French fiction, The Kites was written shortly before Gary’s suicide, and tells the story of two young lovers – one an orphan raised by his uncle, a gentle French kite-maker, the other a Polish aristocrat – separated by the chaos and carnage of World War Two. Epic and empathetic, it’s rich in Gary’s signature themes and preoccupations, such as idealism, the loss of innocence, and the ways in which less than heroic choices can still be moral choices.


but the opportunity at Jask was too enticing. I passed on my sword, but we’re doing fun work here.

GamesBeat: Where are you based now?

Elam: Our HQ is in Austin. There’s a Blizzard office in Austin, which is mostly customer support, but they also run the World of Warcraft website and the Diablo III website. That’s where I worked.

GamesBeat: I don’t know if you can talk about everything you did, but what were the tasks you worked on at Blizzard?

Elam: I was hired to redesign the World of Warcraft website and the Armory app, where players could view their character profiles. Those were two of the bigger projects I worked on, as well as supporting design work on Diablo III. Diablo III, while I was there, released the Rise ///no description available
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(12,8),Register::ReadWriteAccess,unsigned> sel3{};
    }
    namespace XbarbSel2{    ///<Crossbar B Select Register 2
        using Addr = Register::Address<0x4005a004,0xffffe0e0,0x00000000,unsigned>;
        ///no description available
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(4,0),Register::ReadWriteAccess,unsigned> sel4{};
        ///no description available
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(12,8),Register::ReadWriteAccess,unsigned> sel5{};
    }
    namespace XbarbSel3{    ///<Crossbar B Select Register 3
        using Addr = Register::Address<0x4005a006,0xffffe0e0,0x00000000,unsigned>;
        ///no description available


136, 172 N.E. 164. In cases involving charges of fraudulent transfer, the underlying facts and circumstances will not appear upon the face of the transaction as its very purpose invites and contemplates secrecy and concealment. Many facts are locked within *987 the breast of the participants in the fraud and only the process of discovery afforded by the courts provide the means to demonstrate the fraudulent character of the transaction. The facts and circumstances are entirely within the knowledge of the participants and manifestly they would not reveal and disclose any fraudulent scheme in which they had participated. It is only by searching inquiry and a complete discovery that the character of the transaction may be revealed and the secrecy and darkness overhanging the transaction dispelled. In casesAs is well known, an IOL is used to replace the natural lens of the human eye when the natural lens becomes incapable of functioning as desired. A typical IOL includes an optic or lens and one or more fixation members for fixing the IOL in the desired position within the eye.
The optic of an IOL may be constructed of hard, nondeformable materials such as polymethylmethacrylate or of soft, deformable materials such as silicone based or acrylic based materials. One advantage of the deformable IOL's is that they can be deformed into a configuration which permits them to be inserted through a smaller incision into the eye.
In deforming the IOL, the optic is typically folded in a way to cause the IOL to have smaller dimensions which enables


mass random grains that are distributed on the wheel and workpiece surface. Such cases that lead to the exploration of machining deformation and removal mechanisms are difficult.

Therefore, numerous researchers adopted scratch tests in terms of experiments and simulation methods which could compare to the grinding process in order to study the removal behavior of ceramics. Cao et al. \[[@B7-micromachines-11-00545]\] found the cutting ability of the tool was significantly improved by the assistance of ultrasonic when comparing the results of scratch tests with and ultrasonic assistance. Furthermore, they put forward that the critical depth of cut for the ductile to brittle transition is increased by 56.25% with ultrasonic assistance. Similarly, Zhu et al. \[[@B8-micromachines-11-00545]\] revealed that SiC was dominated by the ductile removal mode when maximum undeformed chip thicknesspolishing was completed on both sides of the workpiece until the average surface roughness Sa was 5 nm, as shown in [Figure 1](#micromachines-11-00545-f001){ref-type="fig"}. It can be found that SiC particles randomly distribute with different orientation, and residual carbides disperse at grain boundary. Scratch tests were performed on a three axis ultra-precision diamond turning machines. A Berkovich indenter was fixed on the aerostatic spindle by a holder with edge-forward orientation. The scratch behavior with different speeds was driven by the spindle rotation. This type of process of varied scratch depths which change from shallow to deep and finally back to shallow can ensure that the material undergoes the ductile to brittle deformation. The SiC workpiece was installed on a Kistler dynamometer (9129AA, Kislter, Winterthur, Switzerland) which is mounted on


equal to 77° and θ is the centerline of the face equal to 65.3°. *d*~1~'s calculated value is 3.58 nm base on the tip radius of the indenter measured in [Section 2](#sec2-micromachines-11-00545){ref-type="sec"}. In this paper, both the critical DBT depth and scratch depth are large than *d*~1~. Therefore, only the third parts should be considered. The project area of *A~N~*, *A~T~* and *A~Ne~* can be obtained by: $$A_{N} = \sqrt{3}/2 \cdot (d + d_{1}) \cdot \tan^{2}\beta \cdot (d + d_{1} + d_{e})$$ $$A_{T} = \sqrt{3} \cdot (d - d_{e}) \cdot (d + d_{e} + 2d_{1}) \cdot \sin\theta/\cos^{2}\theta$$ $$A_{Ne} = 3\sqrt{3} \cdot (d_{e} + d_{1}) \cdot d_{e} \cdot \sin^{2}\theta/\cos\theta$$ where *d~e~* is depth caused by elastic recovery.

According to the reference, the elastic recovery depth can be given by thegroove surface had no cracks and the groove width increased steadily with the increase in scratch depth. This implies that elastic and plastic deformation dominate the machining process at such shallow scratch depths. Furthermore, the corresponding scratch force increased smoothly during this period. In the following stage when the normal force and tangential force reached 0.542 and 0.363 N, respectively, microcracks emerged first at the bottom of the scratch groove. The scratch force exhibited obvious fluctuation as marked in [Figure 7](#micromachines-11-00545-f007){ref-type="fig"}a, which suggests that the mode of machining transition into the transition phase before reaching the entirely brittle mode. As the critical depth of DBT is reached, cracks form and propagate at the sides of the scratch groove, and the corresponding force becomes unstable until the end of


also explain why the depth of DBT increased with the increase in scratch speed.

4.4. The Depth of DBT and Subsurface Damage {#sec4dot4-micromachines-11-00545}
-------------------------------------------

From Raman spectra collected from beneath the scratch groove, it can be confirmed that plastic deformation of HP-SiC ceramics is governed by lattice defects (known as dislocations) and a small amount of amorphous transformation. The crystal is transported by the dislocations via bond splitting and the reforming process, and it eventually exits the grain leaving behind an atomic step in its wake. Afterwards, while the dislocations pass through each adjacent grain, the significant macroscopic strain, and hence ductility, are formed. Additionally, it is reasonable to believe that the density of dislocations and amorphous transformation are higher at high scratch speed. Afterwards, with the movement of dislocations, itled to fire-management plans based on pyrodiversity rhetoric that lacks substance in terms of operational guidelines and capacity for meaningful evaluation. We also suggest that not all fire patterns are ecologically meaningful: this seems particularly true for the highly fire-prone savannas of Australia and South Africa. We argue that biodiversity-needs-pyrodiversity advocacy needs to be replaced with a more critical consideration of the levels of pyrodiversity needed for biodiversity and greater attention to operational guidelines for its implementation.


in addition to the ER pattern, a juxtanuclear accumulation (**a**, arrows) that partially overlapped with the ERGIC and *cis*-Golgi stains. Some of the cells also showed weak cell surface stain (asterisk). Nuclei were stained with Draq5 as depicted in blue. All samples are shown in a bright-field mode to delineate the overall structure of the stained cells. Region of interest (ROI) from selected cells is quantified and a scatter plot with pearson's coefficient is given.Scale bars, 10 μm

We next compared the endogenous expression pattern with the green fluorescent protein (GFP) fusion of H-2K^b^, GFP-H-2K^b^, in which the ER-lumenal amino terminus of H-2K^b^ is fused to the carboxy terminus of GFP \[[@CR2]\]. We used an N-terminal fusion, rather than the C-terminal fusion used by Edidin and coworkers \[[@CR24]\]. MEF cellsthe trans-Golgi membranes and the trans-Golgi network. Cells were then either treated with cycloheximide in the presence or absence of rapamycin, or left untreated. The Golgi structure (as detected by the fluorescence of GalT-mCherry) was maintained even after prolonged (6 h) incubation with cycloheximide (Fig. [6](#Fig6){ref-type="fig"}, first panel). Thus, the trapping effect is not mediated by the disintegration of the Golgi structure, but rather reflects the recycling of our tracked proteins. Consistent with our hypothesis, MHC class I trapping by Cerulean-FKBP-Ii was again observed (Fig. [6](#Fig6){ref-type="fig"}, second panel). This confirms the cycling of Venus-FRB-K^b^ molecules between the *cis*-Golgi and the ER and validates our assay.Fig. 6Integrity of the Golgi apparatus in the presence of rapamycin. The Golgi structure is maintained even after six hours incubation of Jurkat cells with cycloheximide and


Casual readers of news coverage of the recent armed takeover of the Malheur National Wildlife Refuge might reasonably assume that the Refuge is strictly protected from livestock grazing. After all, that’s one of the things the vigilantes were protesting, right? The big, bad federal government locked up the lands from grazing and they were there to take it back?

Sadly, that yarn is far from the truth.

In fact, much of the wildlife refuge is grazed by private cattle, and even “hayed” for livestock feed, despite these activities’ dubious legality and harmful impacts on wildlife.

The Refuge is Grazed and Hayed

According to a recent High Country News article, grazing was first allowed decades ago to placate local ranchers:

During the Depression years of the 1930s, the federal government paid the Swift Corp.[ n ] or NOINLINE [ n ] pragma on ‘ $$ ’

This demonstrates an important interaction between inlining and rewrite rules. We need to make sure that expressions that need to be rewritten are not inlined first. If they are first inlined, then GHC won't be able to rewrite them to our more optimized version.

A common approach to this is to delay inlining of functions until a later simplification phase. The GHC simplification process runs in multiple steps, and we can state that rules and inlining should only happen before or after a certain phase. The phases count down from 2 to 0, so we commonly want to delay inlining of functions until phase 0, if they may be subject to rewriting.

Conversely, some functions need to be


inlined before a rewrite rule can fire. In stream fusion, for example, the fusion framework depends on the following sequencing to get good performance:

map f . map g unstream . mapS f . stream . unstream . mapS g . stream unstream . mapS f . mapS g . stream unstream . mapS ( f . g ) . stream

In conduit, we need to make sure that all of this is happening in the correct order. There was one particular complexity that made it difficult to ensure this happened. conduit in fact has two core datatypes: Pipe and ConduitM , with the latter being a more friendly newtype wrapper around the first. Up until this point, the code for the two was jumbled into a single internal module,we be able to case analyze our datatypes, while theoretically the former does not: something like difference lists for simple appending would be ideal. In the past, I've tried out a number of different alternative implementations of conduit, none of which worked well enough. The problem I always ran into was that either monadic bind became too expensive, or categorical composition became too expensive.

Roman, Mihaly, Edward and I discussed these issues a bit on Github, and based on Roman's advice, I went ahead with writing a benchmark of different conduit implementations. I currently have four implementations in this benchmark (and hope to add more):

Standard, which looks very much like conduit 1.1, just a bit simplified (no rewrite rules, no finalizers, no leftovers).

Free, which is conduit rewritten to explicitly


crude oil is processed into gasoline and other byproducts.

CSB investigator Mark Wingard offered an update on the agency's investigation at the start of the meeting. He said the cause of the incident was very similar to that of an explosion at an ExxonMobil refinery in Torrance, Calif., in 2015.

Both incidents also took place at a moment when the refineries were nearing the end of an operating cycle. The Superior refinery was in the process of shutting down for maintenance after running since 2013.

Both explosions also occurred near tanks containing hydrogen fluoride. In the CSB's final report on the Torrance incident, the agency called it a "near-miss event" in which explosion debris nearly hit tanks containing the toxic chemical.

Hydrogen fluoride questions remain: Husky reports 300 percent profit gain in\prod_{n=s}^\infty \l(1-\l(qq_1\r)^n q^{m_2+m_3+d+2}q_2^{m_2}q_3^{m_3}q_4^{m_4}\r)\r).$$ There are similar expressions for the other three products, which arise by permuting $q_i$’s above. We will now look at the $B$ term, and obtain its nested product representation. Written in terms of the $q_i$s, the first product that enters in $B$ is $$\begin{split}
\prod_{m_i=0}^\infty \prod_{s=1}^\infty &\prod_{k=1}^s \l(1-\l(qq_1\r)^{(m_1+s+1)}q^{m_2+m_3+d+2}q_2^{m_2+k}q_3^{m_3+k}q_4^{m_4}\r)\\ &= \prod_{m_i=0}^\infty \prod_{k=1}^\infty \prod_{s=k}^\infty \l(1-\l(qq_1\r)^{(m_1+s+1)}q^{m_2+m_3+d+2}q_2^{m_2+k}q_3^{m_3+k}q_4^{m_4}\r),
\end{split}$$ where we have changed the products over $k$ and $s$. This enumerates the same combinations $(k,s)$ as the previous product. Again, redefining $a+s$ to $a$, and $s-k$ to $s$, we get $$\begin{split}
\prod_{m_i=0}^\infty \prod_{k=1}^\infty &\prod_{s=0}^s \l(1-\l(qq_1\r)^{(m_1+s+1)}q^{k+m_2+m_3+m_4+2}q_1^k q_2^{m_2+k}q_3^{m_3+k}q_4^{m_4}\r)\\ &= \prod_{k=1}^\infty \prod_{m_i=0}^\infty   \l(1-\l(qq_1\r)^{(m_1+1)}q^{k+m_2+m_3+m_4+2}q_1^k q_2^{m_2+k}q_3^{m_3+k}q_4^{m_4}\r)^{m_1+1},
\end{split}$$ from which we can write the nested form $$\prod_{k=1}^\infty \prod_{m_{2,3,4}}^\infty \prod_{s=1}^\infty \prod_{n=s}^\infty \l(1-\l(qq_1\r)^n q^{k+m_2+m_3+m_4+2}q_1^k q_2^{m_2+k}q_3^{m_3+k}q_4^{m_4}\r)$$ Note that is just the $k=0$ term in this product. We can write the contribution


[**550**]{} (2002) 213 \[hep-th/0210114\]. S. Giombi and X. Yin, “Higher Spin Gauge Theory and Holography: The Three-Point Functions,” JHEP [**1009**]{} (2010) 115 \[arXiv:0912.3462 \[hep-th\]\]. S. Giombi and X. Yin, “Higher Spins in AdS and Twistorial Holography,” JHEP [**1104**]{} (2011) 086 \[arXiv:1004.3736 \[hep-th\]\]. M. Henneaux, S. -J. Rey, “Nonlinear $W_{infinity}$ as Asymptotic Symmetry of Three-Dimensional Higher Spin Anti-de Sitter Gravity,” JHEP [**1012**]{}, 007 (2010). \[arXiv:1008.4579 \[hep-th\]\].

A. Campoleoni, S. Fredenhagen, S. Pfenninger, S. Theisen, “Asymptotic symmetries of three-dimensional gravity coupled to higher-spin fields,” JHEP [**1011**]{}, 007 (2010). \[arXiv:1008.4744 \[hep-th\]\].

M. R. Gaberdiel, R. Gopakumar, “An $AdS_3$ Dual for Minimal Model CFTs,” Phys. Rev.  [**D83**]{}, 066007 (2011). \[arXiv:1011.2986 \[hep-th\]\].

A. Castro, A. Lepage-Jutier and A. Maloney, “Higher Spin Theories in AdS(3) and a Gravitational Exclusion Principle,” JHEP [**1101**]{}, 142 (2011) \[arXiv:1012.0598 \[hep-th\]\].

S. Minwalla, P. Narayan, T. Sharma, V. Umesh and X. Yin, “Supersymmetric States in Large N Chern-Simons-Matter Theories,” JHEP [**1202**]{} (2012) 022 \[arXiv:1104.0680 \[hep-th\]\]. C. -M. Changcomposite?
False
Let h = -1 - -9. Let n be 1612/h - (-2)/4. Suppose 2*k = n - 24. Is k a prime number?
True
Is 3/5 + 3562/5 composite?
True
Let h(b) = 2*b - 3*b + 0 + 37*b**3 + 1. Is h(1) a prime number?
True
Let j = -428 + 232. Let l = 67 - j. Is l prime?
True
Let x = 405 - 154. Is x prime?
True
Let p be 1/(-4) - 177/(-4). Suppose 0 = 5*d - 121 - p. Is d a composite number?
True
Let k = 4 + 1. Suppose -p = -k*p + 248. Is p composite?
True
Suppose 0 = 5*v + 3*v - 16440. Suppose 4*w - 3*p + p - 1636 = 0, 5*w - 5*p = v. Is w composite?
True
Suppose -3*n = -2313 + 444. Is


Rutherford et al. reply to Smerdon (http://www.meteo.psu.edu/~mann/Mann/articles/articles.html); it looks like they transcribed the wrong one.

Hmmm...thinking about this; the rutherford comment acknowledges problems, but then concludes pretty much across the board that none of these errors had an impact upon outcomes. well, then why bother with the methods at all? if having data off by 180 degrees does not jack up your analysis, what will?

They also note no observable significant loss of variance (i am going by memory, having just read this). to me, the modeling looks like it does lose variance - peaks are not as peaked, valleys not as low. visually/observably.

in prediction models, these modest limits can play out unfavorably. the models are "trained" based on some set of predictors, and the temp record is reconstructed -Unspeakably Evil: Trump Feeds Kids

Un. Be. Lievable.

Several sources at the White House are confirming that Trump did the unthinkable: he bought food for some college kids.

Then, do you know what he did?

Trigger warning: he fed them. That's right: fed them. FOOD. In their mouths.

Pardon us while we scream at the sky in disgust!!!

It is time for the left and the few sane people on the right to come together with one goal in mind: impeachment. Trump sometimes does bad things. Sometimes he says bad things. But rarely has he stooped to this level.

Say it with us: IMPEACH 45! IMPEACH 45!

We just can't believe that the year is 2019, and Trump is spending his own money to feed defenseless kids.

WON'T SOMEBODY THINK OF THE CHILDREN!?!

Get Free Access To Our


Ben Ainsworth (knee) will miss four to six weeks while co-captain David Swallow (knee) and key defender Sam Collins (concussion) will have to pass fitness tests.

Verdict: Holman should come in for Ainsworth and Brodie should be Swallow's replacement if the skipper doesn't overcome his knee problem. – Michael Whiting

Get them in: Star midfielder Josh Kelly wasn't risked against Essendon last week but trained solidly on Sunday and could be ready to return. Draftee Jackson Hately and backman Isaac Cumming impressed in the reserves, while defender Nick Haynes played three quarters of the NEAFL scratch match after recovering from a back issue.

Under the pump: Leon Cameron might have some tough calls to make if he has some stars fit to play West Coast, and Jeremy Finlayson and Daniel Lloydaway from a return to football but could make his way back through the VFL, while veteran Grant Birchall is still a way off after a setback with a calf.

Verdict: Doubt there will be many changes, except to make way for Wingard. – Nat Edwards

Will recruit Chad Wingard make his long-awaited debut for Hawthorn? Picture: AFL Photos

Get them in: Star defender Steven May will come straight in for his first match in the red and blue after missing round one through suspension. Former Suns teammate Kade Kolodjashnij is also a likely inclusion after performing strongly in a VFL practice match on return from a groin injury. Billy Stretch and Josh Wagner were others to impress.

Under the pump: With May to come back in, Sam Frost will come under


the Blues, while Matthew Broadbent missed the SANFL trial with a hamstring injury.

Verdict: The Power will go in unchanged. Wines and Hartlett will return in round three. – Lee Gaskin

Get them in: Brandon Ellis was a standout in his new midfield role, picking up a casual 40 disposals against Northern Blues in a VFL practice match, while draftee Jack Ross also impressed. Back flanker Oleg Markov was in hot form over pre-season and again played strongly in the VFL.

Under the pump: There weren't many passengers in Richmond's win over Carlton. Debutant Noah Balta had only five touches but will hold his spot, potentially moving down back to cover for Alex Rance.

Medical room: Rance had a right knee reconstruction on Tuesday and is expected to miss the year. Hisdisposals on the weekend, while Will Hayes, the final pick in the 2018 NAB AFL Draft, had 28 touches of his own and looked comfortable back in the Footscray guernsey.

Under the pump: A winning start to the season will ease the pressure valve. Bulldogs coach Luke Beveridge said the decision to select emerging ruckman Tim English ahead of the more experienced Jackson Trengove for round one was difficult and the latter did his best to increase the headache with 28 possessions, 29 hitouts and three goals in a standout VFL performance. Sydney ruckman Callum Sinclair took the points against English, but the 21-year-old was far from disgraced.

Medical room: Matt Suckling's ankle injury at Marvel Stadium certainly generated plenty of discussion. The veteran defender limped from the field early


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How To Start Out a Lifestyle Blog

You are considering starting a lifestyle blog, but are not sure where to start. Workouts, healthy nutrition, and style might already be in your blood, and you just need a little direction of how to tie them all together. It will be your online diary, but now the question is how are you going to show it to the right public in order to build an engaging community.

Here are a few tips and tricks to consider on the way:

1. Be transparent in your endeavors. Let others know up front if you’re selling or marketing a product. Transparency is the only way of gaining your customer’s trust.

2. Let your audience know who you are and who you aspire to become. Have aBesides, OmpA activated MAPK/JNK signaling pathway and enhanced the phosphorylation levels of JNK, p38, and ERK, c-Jun. Inhibition of JNK signaling pathway suppressed OmpA-induced autophagy in HeLa cells. Ab wild-type strains carrying OmpA triggered incomplete autophagy and resulted in a large number of IL-1β production. Ab-△OmpA strain (OmpA gene mutation) restored autophagic flux and reduced the accumulation of p62 and the release of IL-1β in HeLa cells. Rapamycin activated autophagy to inhibit OmpA-induced IL-1β secretion and protect HeLa cells from inflammatory damage. Collectively, these results suggest that OmpA can induce autophagy in HeLa cells through MAPK/JNK signaling pathway. Pre-treatment with Rapamycin activates autophagy and protects against cell death.


/* breakout - the classic computer game where you try to knock out all the
 * bricks with a ball that bounce off the walls and your paddle
 */
#pragma poco echo "expect>g undefined"

#define TRUE 1
#define FALSE 0

/*** A disk object
 ***/
typedef struct disk
	{
	int color;
	int x,y;
	int radius;
	} Disk;
void disk_init(Disk *this, int color, int x, int y, int radius);
void disk_draw(Disk *this);

/*** A rectangle object
 ***/
typedef struct rect
	{
	int color;
	int x,y;
	int width, height;
	} Rect;
void rect_init(Rect *this, int color, int x, int y, int width, int height);
void rect_draw(Rect *this);
Boolean rect_hit(Rect *this, Disk *d);

/*** Object to define the bouncing
 *** ball.
 ***/
typedef struct ball
	{
	Disk draw;
	int dx,dy;
	} Ball;
void ball_init(Ball *this, int color, int x, int y, int radius, int dx, int dy);
void ball_draw(Ball *this);

/*** Object to define a single
 *** brick.
 ***/
typedef struct brick
	{
	Rect draw;
	}Brick;
void brick_init(Brick *this, int color, int x, int y, int width, int height);
void brick_draw(Brick *this);
Boolean brick_hit(Brick *this, Ball *ba);

/*** Object to define the player's
 *** paddle.
 ***/
typedef struct paddle
	{
	Rect draw;
	} Paddle;
void paddle_init(Paddle *this, int color, int x, int y, int width, int height);
void paddle_draw(Paddle *this);
Boolean paddle_hit(Paddle *this, Ball *ba);

/*** Object to define a wall of the
 *** playing area.
 ***/
typedef struct wall
	{
	Rect draw;
	int facex, facey;		/* Which way the ball bounces off it. */
	} Wall;
void wall_init(Wall *this, int color, int x, int y, int width, int height,
	int facex, int facey);
void wall_draw(Wall *this);
void wall_hit(Wall *this, Ball *ba);

/*** Object to define a player's
 *** score.
 ***/
typedef struct score
	{
	int color;
	int x, y;
	int count;
	} Score;
void score_init(Score *this, int color, int x, int y, int count);
void score_add(Score *this, int amount);

/*** Object to save the


= GetColor();
this->filled = GetFilled();
this->two_color = GetTwoColor();
GetInk(this->ink);
}

void pjstate_restore(Pjstate *this)
{
SetColor(this->ccolor);
SetFilled(this->filled);
SetTwoColor(this->two_color);
SetInk(this->ink);
}

/*** Game methods
 ***/
typedef struct game
	{
	int back_color;
	int screenw, screenh;
	int wall_thick;
	int arenaw, arenah;
	int brick_spacing;
	int brick_thick;
	int brick_width;
	Wall walls[4];
	Score score;
	Paddle paddle;
	Brick *bricks;
	int brick_count;
	int xbricks;
	int ybricks;
	} Game g;
Boolean game_init(int xbricks, int ybricks,
	int back_color, int wall_color,
	int paddle_color, int ball_color, int score_color)
{
#define DW 320		/* unscaled dimensions */
#define DH 200
int i,j, x,y;

g.xbricks = xbricks;
g.ybricks = ybricks;
g.back_color = back_color;
GetSize(&g.screenw, &g.screenh);
g.wall_thick = 4*g.screenh/DH;
g.brick_thick = 4*g.screenh/DH;
g.brick_width = 15*g.screenw/DW;
g.brick_spacing = g.screenh/DH;
g.arenaw = 2*wall_thick + (xbricks+1)*g.brick_spacing + xbricks*g.brick_width;
g.arenah = g.screenh;
wall_init(&g.walls[0], wall_color,
		  0, 0,
		  g.arenaw, g.wall_thick, 0, 1);
wall_init(&g.walls[1], wall_color,
		  0, g.arenah - g.wall_thick - 1,
		  g.arenaw, g.wall_thick, 0, -1);
wall_init(&g.walls[2], wall_color,
		  0, 0,
		  g.wall_thick, g.arenah, 1, 0);
wall_init(&g.walls[3], wall_color,
		  g.arenaw - g.wall_thick - 1, 0,
		  g.wall_thick, g.arenah, -1, 0);
score_init(&g.score, score_color, g.arenaw + g.wall_thick, 0, 0);
g.brick_count = xbricks*ybricks;
if ((g.bricksCutaneous Langerhans cell histiocytosis : The spectrum of a rare cutaneous neoplasia.
Langerhans cell histiocytosis (LCH) is a rare disorder that is now recognized as a true malignancy of dendritic Langerhans cells. Various somatic mutations have been discovered for BRAF and MAP kinases. The clinical variability is remarkable. A very rare variant is cutaneous LCH without internal organ manifestations. We present a case series of cutaneous LCH illustrating the spectrum of clinical symptoms, treatment, and disease course. Cutaneous LCH needs a careful investigation of possible internal involvement and a long follow-up since second malignancies may develop over time. Overtreatment should be avoided, since too-aggressive treatment will not improve the outcome.


Sodium- and potassium-activated ATPase in the mammalian vestibular system.
Autoradiographic and cytochemical procedures were employed to determine the cellular distribution of the Na,K-ATPase enzyme in the mammalian vestibular system. A light-microscope survey of vestibular tissues incubated with [(3)H]ouabain shows high densities of ouabain binding sites within the dark cell epithelium (DC) of the ampullae of the semi-circular canals, and to a lesser extent, the DC of the utricular macula. A moderate number of binding sites was found in nerve fibers penetrating the connective tissue beneath the sensory epithelium (SE) of the ampullae and the maculae. A small number of binding sites is distributed in the deep portion of the SE, both in the ampullae and in the maculae. These latter binding sites seem to be associated with nerve terminalsStead, 746 F.2d 355,  356-57 (6th Cir. 1984) (declining to vacate guilty plea though  district court admittedly failed to warn defendant of right against  self-incrimination and right to confront witnesses), with United  States v. Carter, 619 F.2d 293, 295 (2d Cir. 1980) (reversing where  district court omitted "core" requirement that defendant be advised  of confrontation rights).


in one of these scenarios
    // 1) mpiexec/smpd connecting to smpd manager/instance
    // 2) smpd reconnect to mpiexec/another smpd
    //
    // Under our current implementation, in both cases the error is
    // happening at a leaf smpd node and no processes have been
    // launched. It is safe (or rather, graceful enough) to just
    // exit this process
    //
    EXOVERLAPPED ov;
    ExInitOverlapped(&ov, smpd_exit_from_rpc, smpd_exit_from_rpc);
    ExPostOverlappedResult(smpd_process.set, &ov, 0, 0);

    //
    // Give the engine 30 seconds to shutdown and then force an exit
    //
   Sleep(30000);
    smpd_err_printf(
        L"\nFailed to terminate smpd manager after 30 seconds. Forcing smpd exit.\n");
    exit( SMPD_EXIT_FROM_RPC );

}

static void
smpd_init_cmd_handlers()
{
    for( unsigned int i = 0; i < SMPD_CMD_MAX; ++i )
    {
        smpd_process.cmdHandler[i] = smpd_handle_invalid_command;
    }

    //
    // Setup handler array to handle commands.  Smpd should only
    // receives these commands. To prevent bogus commands due to
    // bugs/corruption everything else is trapped in
    // smpd_handle_invalid_command which will trigger the abort job
    // process
    //
    smpd_process.cmdHandler[SMPD_BARRIER] =


        smpd_err_printf(L"Cannot set unicode mode for std streams\n");
            goto fn_exit1;
        }
    }

    HeapSetInformation(NULL, HeapEnableTerminationOnCorruption, NULL, 0);

    HRESULT hr;
    PmiServiceInterface pmiServiceInterface;

    /* Make SMPD a trace event provider. */
    EventRegisterMicrosoft_MPI_Channel_Provider();

    HANDLE hProcessToken;
    BOOL fSucc = OpenProcessToken(GetCurrentProcess(), TOKEN_QUERY, &hProcessToken);
    if(!fSucc)
    {
        hr = HRESULT_FROM_WIN32( GetLastError() );
        smpd_err_printf(L"OpenProcessToken failed, error 0x%08X\n", hr);
        goto fn_exit1;
 mesh product.

Kugel mesh is not the only hernia repair medical device to cause medical issues in patients who have undergone implant surgery. Other mesh devices causing medical problems and facing multiple pending lawsuits. For example, Atricum C-Qur reportedly causes several issues including failing to incorporate into the body, severe inflammation and infections, opening of the surgery site weeks or even months after the surgery, adhering to the patient’s bowel making it more difficult to remove if there are complications, as well as severe scar tissue. Atrium C-Qur is different from other meshes in that it has a fish oil coating.

Likewise, in 2016 Johnson & Johnson’s withdrew its Ethicon PhysioMesh from the market after an unusually large number of problems with the device were reported by two large hernia


higher than the control, all other test biochemical indicators were decreased significantly (P < 0.05). It was suggested that short-term exposure to higher concentrations of Cd would lead to the obstruction of energy supply and utilization due to the inhibition of PFK and ATPase activity and the oxidative damage of mitochondria resulted from the decrease of SOD activity, and decrease the ability of gills in regulating plasma ion composition and osmolality, which could be one of the possible mechanisms for Cd toxicity.Background {#Sec1}
==========

Recently, ion/block copolymers (BCPs) hybrids have become highly attractive materials due to their flexibility, process stability, self-assembling ability and novel features of inorganic components such as electronic, magnetic and optical properties \[[@CR1]--[@CR3]\]. Spatz and co-workers created fused silica substrates with nanopillars on both sides with 99.8% transmittance and 0.02% reflectance, which was helpful for many laser applications \[[@CR4]\]. Black et al. fabricated densely packed silicon nanotextures with feature sizes smaller than 50 nm by block copolymer self-assembly to enhance the broadband antireflection of solar cells \[[@CR5]\]. Morris et al. fabricated Si nanowire array by self-assembly of block copolymer with LiCl, which showed the possible application in the area of photonics and photoluminescence \[[@CR6]\].

Compared with diblock copolymers (diBCPs), ABC triblock copolymer (triBCPs) can assemble into new morphologies such as


to grips with traditional based faiths. I love the thought the concept of God, you speak about, is everywhere and in everything.

Davy, I am so glad to hear that this post gave you some peace in the struggle that you and many have with traditional religions and dogmas. Faith is a totally different thing and puts us also in a place of responsibility.
Thank you for your kind words
miriam

Beautiful and heartwarming, Miriam! I still remember visiting the wonderful cathedral of Seville – the beauty of it and to imagine it was built by humans was sheer overwhelming.
Have a lovely weekend! 😊

Thank you Sarah for your kind comment. Cathedral of Seville; it is known to be beautiful and set in a beautiful area.
Yes, imagine how many people and generations workedtransformation and regulation of the immune system ([@ref28], [@ref29]). These cells may provide proper condition for transplantation as they did not show tumorigenicity and adverse immunological responses ([@ref19]). Human placental cells decrease the risk of zoonosis in culture location ([@ref30]). So, from the above mentioned properties, placental cells including amniotic and chorionic cells can provide an appropriate micro-environment for induction of HUMSCs. The aim of this study was to investigate the expression of PGC and oocyte like cell markers in HUMSCs. To accomplish this objective, we used placental cells to induce HUMSCs and to identify whether these cells were able to generate primordial germ cells and express principal oocyte-like cell markers *in vitro*.

Materials and Methods {#sec1-2}
=====================

Isolation and expansion of HUMSCs {#sec2-1}
---------------------------------

All the sampling procedures were performed according to


evaluated with inverted phase contrast microscope (Olympus CKX-41). Cells upon 80 to 90% confluency were passaged and the medium was refreshed every other day. Cells from passages 3 to 4 were utilized for differentiation studies.

Differentiation into osteoblasts {#sec2-2}
--------------------------------

HUMSCs were treated with osteogenic medium (Gibco-Invitrogen) for 21 days with twice a week medium change. The flasks were assessed every 3 days for osteogenesis. Osteogenesis progress was evaluated with Alizarin-red S staining. The cells were fixed with 4% paraformaldehyde and stained with 1% Alizarin-red S (Sigma-Aldrich) solution for 10 min.

Differentiation into adipocytes: {#sec2-3}
--------------------------------

HUMSCs were treated with adipogenic medium (Gibco-Invitrogen) for 21 days and the medium was refreshed every 3 days. The cells were assessed every 3 days. Adipogenesis was evaluated by Oil Red-O staining. Briefly, the cells were fixed withreally enjoyed writing it, and that's kind of a history of the book." "And I hope you enjoy it, or enjoyed it." "Uh, you know, stay scared." "Right?" "Any questions?" "Where's the scariest place you've ever been?" "Scariest place I've ever been?" "Uh, I've never heard that question before." "That's a joke." "Well, all these places have very colorful histories." "Um..." "I would say, if I had to pick a top one," "I would say Bar Harbor, the site of the grisly McTeig wedding night murders." "That's an intense place." "Or maybe St. Cloud, Minnesota, where the crazed war widow threw her baby down a well." "I mean, those all have a lot of" " I mean, it's thick." " The air is thick." " What about poltergeists?"


facilities," " it will leave you feeling relaxed..." " Hello?" "And revitalized." "Your call is important to us" "You bitch." "You win." "You win." "All right." "Okay!" "Come on." "Come on!" "Come on." "Come on." "Hey!" "Help!" "Help!" "Help!" "Help!" "Can anybody hear me?" "Help!" "You!" "Sir!" "Sir!" "Help!" "Yeah!" "Yeah, you!" "Help!" "Help!" "Help!" "You, sir!" "Help!" "Can you see me?" "Yeah!" "The Dolphin Hotel!" "Call the police!" "Help!" "Help!" "Hey!" "I'm losing my mind." "Girl's voice:" "I can see you, Dad." "Daddy?" "Daddy, where are you?" "I'm gonna get you." "Ready or not, here I come." "Here you are." "I see you, Daddy." "Get ahold of yourself." "You're running to places that aren't real." "Get up." "Get up." "You're losing the plot." "You're losing the wholesurf." "You flew here just for me?" "Yeah." "Yeah, I was worried." "They called." "I think I'm still listed as your next of kin." "Okay, I'm not in New York." " I'm out." " Why do you keep saying that?" "I was in New York." "I was trapped." "In New York, I was dying in this Kafkaesque hotel, the Dolphin." " What?" " The Dolphin Hotel on 45th and Lex." " I spoke with you there." " 45th and Lex?" " I called you." " I've never heard of it." "You're gonna be okay." "You just need to rest." "Oh, we have a winner." "600 bucks." "Unbelievable." "I can see why you live here." "Why did you leave?" "Because every time I looked at you," "I saw her


get this to New York by tomorrow morning." "Man:" "I'm sorry, sir, but we're closed." "Very well." "I was out!" "I was out!" "I was out!" "I was out." "Please, God." "I know I was out." "Yeah." "Open it." "Preacher:" "... are yawning up widely in our path." "We know the way of the righteous man." "Katie:" "Daddy." " Daddy?" " No." " You're not Katie." " I need help." "Please." "You're not real." "I'm cold." " You're not Katie." " So cold." "I love you, Daddy." "Don't you love me anymore?" "Of course I do, sweetheart." "There we go." "I got you." "I got you now, Katie." " Oh my God." " They won't let me stay." " Yes, they will." " They won't let me stay."(and some adult) rat CM after infection with recombinant adenoviruses to alter principal cell cycle regulators [@pone.0003896-Bicknell1]; however, adenovirus gene transfer vectors can induce cell cycle dysregulation and inappropriate expression of cyclin proteins, which complicate the interpretation of published studies [@pone.0003896-Wersto1]. Transgenic mouse models have also been extensively employed but are subject to developmental compensation or even embryonic lethality [@pone.0003896-Bicknell1]. Use of inducible systems has helped eliminate these problems, but mouse models are time-consuming and expensive [@pone.0003896-Yutzey1]. Embryonic stem (ES) cell derived cardiomyocytes (CM) have been proposed as an alternative model system to study CM cell cycle regulation [@pone.0003896-Klug1], but to date, these experiments have only involved heterogenous cultures with unpurified cells.

From these diverse studies, it is generally accepted that over-expression of molecules (cyclins D1, D2, D3, cdk2


features typical of immature primary myocardium and one cell was AV-like; whereas, between D7+5--11, all but three cells displayed a more mature phenotype typical of atrium, ventricle and nodal regions (sinus and atrio-ventricular).

Highly Purified Early Stage Cardiomyocytes Derived From ES cells {#s2b}
----------------------------------------------------------------

*W*e optimized a 6-step protocol to isolate a highly purified population of proliferating CM from syNP4. Using the hanging drop technique and induction with ascorbate, both individual and multiple foci of spontaneously contracting areas were observed within one day of EB plating. To maximize cell purity, EBs (D7+1) were digested with collagenase to obtain single cells or small clusters of cells. This heterogeneous cell population was replated, and within 24--48 hours of puromycin selection, a monolayer culture of contracting cells was observed ([Figure 2A](#pone-0003896-g002){ref-type="fig"}). Within 3 toto transfection with a nontargeting siRNA or no transfection control. The most efficient reduction of Rb transcripts was in cells transfected with siRNA-Rb8, and only these data are shown unless indicated. No significant difference in p107 and p130 expression could be demonstrated at any timepoint examined following KD of Rb; however, Rb transcripts were decreased by \>60%. Comparable results for each pocket protein were observed on Western blots ([Figure 6C](#pone-0003896-g006){ref-type="fig"}), except that the Rb protein was decreased to a greater extent (80--90%) than the RNA. Thus expression of Rb could be specifically reduced without any changes in expressions of p107 and p130.

![Knockdown of Rb alters the expression of factors implicated in the G1 to S phase transition.\
A) Image of purified ESCM transfected with siGlo RNA showing that \>90%


it\'s expression is not restricted to CM [@pone.0003896-Wu1], [@pone.0003896-Christoforou1]. In rodent heart development, α-MHC is only weakly expressed in the primary myocardium before it becomes restricted to atrial regions throughout the remainder of embryonic and early fetal development [@pone.0003896-Franco1]. It is therefore most useful for the preferential selection of ES-derived atrial cells [@pone.0003896-Kolossov1]. The *mlc2v* promoter has been used to identify "ventricular" myocytes from differentiating ES cells *in vitro* [@pone.0003896-MillerHance1], but its "specific" expression is only apt for adult rodent heart. During development, it\'s expression is restricted to anterior (atrial and atrio-ventricular) portions of the heart tube, and at later stages, in the caval myocardium [@pone.0003896-Franco1], [@pone.0003896-Christoffels1]. The activity of the cardiac α-actin gene promoter is also robust in heart, but it is expressed in skeletal muscle cellsachieve a high purity of CM [@pone.0003896-Zandstra1]. Although no specific analysis of the cell cycle was performed in Zandstra\'s study, at least some of these cells continued to proliferate even at late time points [@pone.0003896-Zandstra1]. In the present study, selected ESCM actively proliferated for only about 3 to 6 days, before a significant reduction in proliferation occurred. These results are in agreement with those of Klug et al. who showed that non-purified ESCM were mitotically active at D11 (equivalent to D7+4 in this study), but at D21, mitotic activity was present in \<1% of cells [@pone.0003896-Klug1]. Apparent differences in proliferation among these studies might be due to culture conditions. In our system and that of Klug et al., CM were cultivated as adherent cells, and as cell densities


the child/parent relationship and whole family interventions.

Support the evaluation of the effectiveness of the youth justice system’s interventions to address child to parent violence (CPV) for adoptive families in which there is CPV. Such 289 interventions include Non Violent Resistance (NVR) and Break4Change.

Examine legislation and guidance to ensure that respite care can be provided without making the child ‘looked after’.

Entitle young people leaving adoptive families to leaving care services, especially support for further education.

Improve training, supervision and support needs for foster carers and family placement workers in relation to the carer’s and professional’s role and responsibilities for children who move from foster care to an adoptive family.

Provide needs led rather than service led interventions. Too often, parents and children got what was available in house and not whatacross the world; the Marriage (Same Sex Couples) Act 2013 is a brilliant step toward equality within England and Wales and one that we should be proud of.

In the last few days I have heard a lot about the case of Gohil v Gohil [2014] on the legal grapevine and so as I finished off for the day yesterday I decided to take a closer look. After reading the case I now understand the hype: in short summary the Husband in this case applied to the Court of Appeal, after his ex-wife successfully appealed to the High Court to have the original consent order in the financial remedy proceedings set aside. During the original financial remedy proceedings the wife was adamant that the husband was not fully disclosing


set aside the April 2004 consent order which was given in a reserved judgement handed down on the 25th September 2012 ([2012] EWHC 2897 (Fam)). and it ‘follows that that decision, which is the decision currently under appeal, was determined without recourse to the disclosure that had been ordered from the criminal proceedings and which, as a result of the Court of Appeal decision, will not now take place.’ (Gohil v Gohil [2014]).

In June 2012 the issue of whether to set aside the consent order came before Moylan J in an eight day hearing, at the end of which Moylan J stated that there were two bases on which the wife could seek to set aside the 2004 consent order:

“a) That there has been non-disclosure which had ledof non-disclosure was such that the court would have made a substantially different order had they known all of the facts.

The husband’s counsel, James Turner QC, upon appealing to the Court of appeal made various submissions the most important being that ‘there are two distinct stages involved in a Livesey v Jenkins application: determining as, a matter of fact, whether there has been material non-disclosure and, secondly, if so, determining whether the original order should be set aside. Any consideration of whether fresh evidence should be admitted can only be within the first stage, and, probably, at a preliminary point in that stage.’ (Gohil v Gohil [2014]). This was picked up on by the judge and upon upholding the husband’s appeal it was stated that it was not


intervention. There are, however, categories of persons that will be exempt from the requirement to attend, including cases concerning:
-domestic violence
-child protection concerns
-Urgency
-Non residence is England and Wales
-Lack of contact details for respondents

The exemption categories can be found in rule 3.8 of the Family Procedure Rules.

It remains to be seen how the requirement to attend MIAM’s will work in practice and indeed whether they will lead to a reduction in Court applications… Only time will tell.

The Senior Judiciary to the Ministry of Justice has criticised the Ministry of Justice’s consultation paper, ‘Court Fees: Proposals for Reform’[i] which aims to increase the court fees across England and Wales. The criticism was published on the 4th of February 2014 and followed previous criticism aired by the Civil Justice Council[ii] in Januarythe domicile of origin revives (Dicey, pages 151 to 153).”’

Lord Justice McFarlane further referred to the leading case of Udny v Udny (1869) 1 LR Sc & Div 441 where ‘the issue was as to the domicile of the respondent’s father at the time of his (the respondents) birth’. The court held that the respondent’s domicile of origin was intrinsically linked to his father’s domicile. Thus while the respondent was born and lived outside of the UK, the respondent’s father’s domicile was Scotland and therefore the respondent’s domicile of origin was adjudged to be Scotland also.

So where does this leave adoptive parents, children who have been adopted and children who were abandoned, not adopted but are later involved in marital litigation?

The Adoption and Children Act 2002 states, at


s.67 (1), that an adopted person is to be treated in law as if the person is the legitimate child of the adopter. Furthermore, Bromley’s Family Law (Oxford University Press) [6th Ed.][vii] states that by virtue of s.67 of the Adoption and Children Act 2002 an adopted child’s original domicile of origin is replaced by a new replacement domicile of origin upon adoption. The adopted child’s domicile of origin is generally accepted as being determined at the time of the child’s birth; however the child’s new domicile of origin will change to that of the adopting fathers. If there is no adoptive father then that of the adoptive mother. This therefore resolves the question of where adopted children stand in regard to their domicile of origin. However, itand that emotional abuse is often not regarded as a crime and is, therefore, not included.

Home Secretary Theresa May, a supporter of the scheme, stated that she is ‘determined to see a society where violence against women and girls is not tolerated, where people speak out, and where no woman or girl has to suffer domestic abuse’[v]. However, there are a few people who are not sure what the law will actually achieve and whether Theresa May’s aims will be realised. Jane Keeper from Refuge, a domestic violence charity, states that ‘most perpetrators of domestic violence are never known to police, social care or the other agencies – so usually if a woman asks the police the likeliest thing, even if he is a perpetrator, is they are


which, in summary, include:

1. House of Commons:

First reading

Second Reading

Committee Stage

Report Stage

Third Reading

2. House of Lords:

First reading

Second Reading

Committee Stage

Report Stage

Third Reading.

3. consideration of amendments.
4. Royal Assent

The draft guidance, ‘Improving the adoption system and services for looked-after children’ was published on the 28th of February 2014 and runs alongside a number draft regulation changes. The premise for the legislative changes and guidance being that the government wishes to see more children adopted without the average two year delay between entering care and moving in with an adoptive family. The changes within the area promote schemes such as fostering with the intention of adopting and are intended to improve the support offered to adoptive families.

Further to this the changes include removing the risk that ethnicity is prioritised over other factors withinVirtual School Head, whose role is to improve and encourage the education of children under the local authorities care.

Children and Families Minister Edward Timpson stated that the ‘reforms to the adoption register, greater use of fostering for adoption and the removal of often unnecessary delay, will mean would-be adopters can play a much greater role in the process and will ensure children who need them are given stable, loving homes with their new families much more quickly. The revised adoption guidance will also make it much easier for social workers to follow the new processes when considering adoption for vulnerable children. It means they can make the best possible decisions in the interests of the 6,000 children waiting for a loving home.’


(BNHS) in 1907.  Prater developed his intimate knowledge of the mammals of the Indian subcontinent during the Society's Mammal Survey (1911–1923), during which he was also grievously wounded when he was accidentally shot in the thigh.

Curator and editor
In 1923, became curator of BNHS and the Prince of Wales Museum of Western India, positions he held for 25 years.  The same year, Prater traveled to Great Britain to train in modern taxidermy.  Four years later he traveled to the  American Museum of Natural History in New York City and the Field Museum of Natural History in Chicago, to learn about techniques of natural history exhibition, knowledge that he brought to bear in the Prince of Wales Museum displays of the next two decades.

During the lastStudies of terminal differentiation of electrolyte transport in the renal proximal tubule using short-term primary cultures.
There are several lines of indirect evidence suggesting that the renal tubule cells have not yet reached terminal differentiation at birth. Methods used in cell biology can now be applied to study renal ontogeny. This review describes how primary cultures of proximal tubule cells from rats can be used to investigate developmental changes in Na permeability and Na-K-ATPase-mediated transport.


of attention from the computer vision community ([@bib60]; [@bib43]; [@bib5]; [@bib71]; [@bib18]). If centroids ('seeds') of the objects are known or can be learned, the problem can be solved by the watershed algorithm ([@bib11]; [@bib9]). For example, in [@bib13] a 3D U-Net was trained to predict cell contours together with cell centroids as seeds for watershed in 3D confocal microscopy images. This method, however, suffers from the usual drawback of the watershed algorithm: misclassification of a single cell centroid results in sub-optimal seeding and leads to segmentation errors.

Recently, an approach combining the output of two neural networks and watershed to detect individual cells showed promising results on segmentation of cells in 2D ([@bib68]). Although this method can in principle be generalized to 3D images, the necessity to trainobtained by imaging wild-type Arabidopsis plants expressing markers for the plasma membrane and the nuclei ([@bib65]) using a light sheet fluorescence microscope (LSFM). Stacks of images were acquired every 30 min with constant settings across movies and time points, with a voxel size of 0.1625 × 0.1625 × 0.250 μm. The first movie consists of 52 time points of size 2048 × 1050 × 486 voxels. The second movie consists of 90 time points of size 1940 × 1396 × 403 voxels and the third one of 92 time points of size 2048 × 1195 × 566 voxels. The ground truth was generated for 27 images depicting different developmental stages of LRP coming from the three movies (see Appendix 1 Groundtruth Creation).

The two datasets were acquired on different types of microscopes and differ in image quality. To quantify the differences we used the peak


performed well on both datasets, giving satisfactory results on all organs from the 3D Digital Tissue Atlas, correctly segmenting even the oval non-touching cells of the anther and leaf: a cell shape not present in the training data ([Figure 4](#fig4){ref-type="fig"}). Our pipeline yielded especially good segmentation results when applied to the complex epidermal cells, visibly outperforming the results obtained using the SimpleITK framework ([Figure 5](#fig5){ref-type="fig"}).

![PlantSeg segmentation of different plant organs of the 3D Digital Tissue Atlas dataset, not seen in training.\
The input image, ground truth and segmentation results using PlantSeg are presented for each indicated organ.](elife-57613-fig4){#fig4}

![Qualitative results on the highly lobed epidermal cells from [@bib16].\
First two rows show the visual comparison between the SimpleITK (middle) and PlantSeg (right) segmentation on two different image stacks. PlantSeg's results on anothersample is shown in the third row. In order to show pre-trained networks' ability to generalized to external data, we additionally depict PlantSeg's boundary predictions (third row, middle). We obtained the boundary predictions using the *generic-confocal-3d-unet* and segmented using GASP with default values. A value of 0.7 was chosen for the under/over segmentation factor.](elife-57613-fig5){#fig5}

Quantitatively, the performance of PlantSeg out of the box (default parameters) on the 3D Digital Tissue Atlas is on par with the scores reported on the LRP and ovules datasets on the anther, leaf, and the root, but lower for the other tissues ([Table 1](#table1){ref-type="table"}, left). Default parameters have been chosen to deliver good results on most type of data, however we show that a substantial improvement can be obtained by parameter tuning (see Appendix


founder cells.\
(**A**) Schematic representation of *Arabidopsis thaliana* with lateral roots (LR). The box depicts the region of the main root that initiates LRs. (**B**) 3D reconstructions of LR founder cells seen from the side and from the front at the beginning of recording (**t**) and after 12 hr (*t+12*). The star and brackets indicate the two daughter cells resulting from the asymmetric division of a LR founder cell. (**C**) Half-violin plot of the distribution of the volume ratio between the daughter cells for three different movies (*\#*1, *\#*2 and *\#*3). The average ratio of 0.6 indicates that the cells divided asymmetrically. Source files used for analysis and violin plot creation are available in [Figure 7---source data 1](#fig7sdata1){ref-type="supplementary-material"}.\
Figure 7---source data 1.Source data for asymmetric cell division measurements in [Figurecell levels.

![Leaf surface segmentation results.\
Reported are the ARand error (**A**) that assesses the overall segmentation quality and the accuracy (**B**) measured as percentage of correctly segmented cells (by manual assessment of a trained biologist). For more detailed results, see [Appendix 5---table 3](#app5table3){ref-type="table"}.\
Figure 9---source data 1.Source data for leaf surface segmentation in [Figure 9](#fig9){ref-type="fig"}.The archive contains: \'final_mesh_evaluation - Sheet1.csv\' - CSV file with evaluation scores computed on individual meshes, \'Mesh_boxplot.pdf\' - detailed steps to reproduce the graphs, \'Mesh_boxplot.ipynb\' - python script for generating the graph.](elife-57613-fig9){#fig9}

Next, we used the PlantSeg segmentation to measure growth over 24 hr at cellular resolution and compare differentiation in *A. thaliana* and *C. hirsuta* 600 µm-long leaves. Growth was slow in the midrib and distal margin cells, whereas the remaining blade displayed a gradient along the


region. (**B**) Top: Segmentation pipeline of MorphoGraphX: a surface mesh is extracted from the raw confocal data and used as a canvas to project the epidermis signal. A seed is placed in each cell on the surface for watershed segmentation. Bottom: PlantSeg facilitates the segmentation process in two different ways (red arrows): By creating clean wall signals which can be projected onto the mesh instead of the noisy raw data and by projecting the labels of the 3D segmentation onto the surface to obtain accurate seeds for the cells. Both methods reduce segmentation errors with the first method to do so more efficiently. (**C**) Fully segmented mesh in MorphoGraphX. (**D--F**) Quantification of cell parameters from segmented meshes. (**D**) Heatmap of cell growth in an *A. thaliana* 8th-leaf 4was performed as previously described [@bib66]; [@bib22] with a confocal laser scanning microscope (Nikon A1, 25 × NA = 1.1) after staining cell walls with DAPI (0.2 mg/ml).

For imaging of *Arabidopsis thaliana* lateral root, seedlings of the line sC111 (*UB10~pro~ :: PIP 1,4-3 × GFP/GAT A23~pro~ :: H2B : 3 × mCherry/DR5v2~pro~ :: 3 × YFPnls/RPS5A~pro~ :: dtTomato : NLS*, described in [@bib65]) were used at 5 day post germination. Sterilized seeds were germinated on top of 4.5 mm long Blaubrand micropipettes (Cat 708744; 100 μl) that were immobilised on the bottom of a petri dish and covered with $\frac{1}{2}$ MS-phytagel ([@bib37]). Before sowing, the top of the micropipettes is exposed by removing the phytagel with a razor blade and one seed is sowed per micropipette. Plates were stratified for two days and


optimizer ([@bib30]) with ${\beta_{1} = 0.9},{\beta_{2} = 0.999}$, L2 penalty of 0.00001 and initial learning rate $\epsilon = 0.0002$. Networks were trained until convergence for 150K iterations, using the PyTorch framework ([@bib45]) on 8 NVIDIA GeForce RTX 2080 Ti GPUs. For validation during training, we used the adjusted Rand error computed between the ground truth segmentation and segmentation obtained by thresholding the probability maps predicted by the network and running the connected components algorithm. The learning rate was being reduced by a factor of 2 once the learning stagnated during training, that is, no improvements were observed on the validation set for a given number of iterations. We choose as best network the one with lowest Arand error values. For training with small patch sizes we used 4 patchesgroundtruth segmentation, PlantSeg segmentation results. PlantSeg provides accurate segmentation of both tissue types using only the networks pre-trained on the *Arabidopsis* ovules dataset. Red rectangles show sample over-segmentation (**A**) and under-segmentation (**B**) errors. Boundaries between segmented regions are introduced for clarity and they are not present in the pipeline output.](elife-57613-app3-fig1){#app3fig1}

Supplemental figures {#s11}
====================

![Precision-recall curves on individual stacks for different CNN variants on the ovule (**A**) and lateral root primordia (**B**) datasets.\
Efficiency of boundary prediction was assessed for seven training procedures that sample different type of architecture (3D U-Net *vs.* 3D Residual U-Net), loss function (BCE *vs.* Dice *vs.* BCE-Dice)) and normalization (Group-Norm (GN) *vs.* Batch-Norm (BN)). The larger the area under the curve, the better the precision. Source files used to generate the precision-recall curves are available in the


 Disabled

###### Parameters guide for CNN Predictions and Post-processing.

Menu B and D in [Appendix 6---figure 1](#app6fig1){ref-type="fig"}.

  Process type                 Parameter name     Description                                                                                (0.0...1.0)   0.6
                                 Run Watersed in 2D         If True the initial superpixels partion will be computed slice by slice, if False in the whole 3D volume at once. While slice by slice drastically improve the speed and memory consumption, the 3D is more accurate.


                                                      bool          False

Empirical example of parameter tuning {#s14}
=====================================

PlantSeg's default parameters have been chosen to yield the best result on our core datasets (Ovules, LRP). Furthermore, not only segmentation performances but also resource requirements have been taken into account, e.g. super-pixels are extracted in 2D by default in order to reduce the pipeline runtime and memory usage. Nevertheless, when applying PlantSeg on a new dataset tuning parameters      0.927                      0.394   1.289   1.005   0.353   0.600   0.915

###### Comparison between the results obtained with three different *over/under segmentation factor* $(0.5,0.6,0.7)$.

The effect of tuning this parameter is mostly reflected in the VOIs scores. In this case the best result have been obtained by steering the segmentation towards the over segmentation.

  ds3 confocal + rescaling


For example, beyond considerations such as microscope modality and voxel size, what are the guiding principles for which partitioning strategy should be selected? If this information is already available, please refer to its location in the main text.

7\) Additionally, the GUI allows users to adjust a number of parameters. To expand the userbase, consider providing an appendix that (1) explains what these parameters mean and (2) outlines the circumstances under which they should be adjusted.

8\) A valuable addition would be a table that lists how PlantSeg interfaces with other image analysis tools, specifically including software packages (in addition to MorphoGraphX) that can perform cell counting, cell tracking, and cell volume and shape measurements on the outputs of PlantSeg.

9\) Finally, in the GitHub repository, the read-me document is helpful,to PlantSeg once they emerge in the bioimage computing community.

> PlantSeg is accessible to non-experts, but its exact advantages over other user-friendly tools such as the U-Net ImageJ plug-in, CDeep3M, or ilastik could use further elaboration. Relative to these methods, what are PlantSeg\'s primary contributions-that it combines CNN-based predictions and more sophisticated post-processing methods for plant tissues?

Regarding the PlantSeg's primary contributions relative to other tools (ImageJ's U-Net plugin, CDeep3M), we have added the following to the Introduction section:

"Combining the repository of state-of-the-art neural networks trained on the two common microscope modalities and going beyond just thresholding or watershed with robust graph partitioning strategies is the main strength of our package."

In more in detail:

We differ from ImageJ's U-Net plugin mainly by the segmentation approach. Our robust graph partitioning is


contain these cells do not seem to have behaved well (likely due to the low quality of the input data) and the work on Cardamine leaves appears to be a combination of MorphoGraphX and PlantSeg. There are other published datasets that include lobed cells from Arabidopsis leaves and also maize leaves (where lobing is of a different nature) and these should be analyzed with PlantSeg alone to demonstrate its effectiveness at segmenting such cells.

We thank the reviewers for pointing out these published datasets. We fully agree that highly lobed cells make for an interesting use case and we have now evaluated Plant Seg on the data from Foxe et al. \[1\].

The results are presented in subsection: "Performance on external plant datasets". We included a new figure to showthe newly proof-read results can then be used to train a better network that can be applied to this type of data in the future (see the appendix \\nameref{sec:ground_truth_creation} for an overview of this process)."

> 7\) Additionally, the GUI allows users to adjust a number of parameters. To expand the userbase, consider providing an appendix that (1) explains what these parameters mean and (2) outlines the circumstances under which they should be adjusted.

We agree that including a parameters guide in the manuscript appendix would greatly help new users. The newly added Appendix 6 contains description of all main parameters available in PlantSeg, while Appendix 7 provides an example of parameter tuning for a particular dataset from the 3D Tissue Atlas.

> 8\) A valuable addition would be a table


their data, goals, and accomplishments with fellow team members. To ease employees’ hesitation and fears about privacy, company leaders ensure that the collected data is only used to support their culture of self-improvement. After a year with the Jawbone devices, the Buffer team has made strides in regards to fitness, well-being, and openness.   The IJ made an adverse credibility determination and found that Cadena

Chunza had failed to establish past persecution or a well-founded fear of future

persecution. The IJ’s adverse credibility determination was based on findings that

Cadena Chunza’s asylum application, which was vague and lacked detail,

contained serious omissions. In particular, the IJ observed that Cadena Chunza’s

application did not refer to the kidnapping incident, which was central to his claim

for asylum. Other details omitted were: the threatening calls received by his

secretary; FARC guerillas’ visit to his store followed by Cadena Chunza’s calling


           5
provides no citation of authority as to how this right was violated. Consequently,

Philmore has abandoned this claim.”).

       As to the credibility determination, Cadena Chunza argues that “the IJ’s

credibility determination relied largely on unimportant or explicable

discrepancies.” Adverse credibility is assessed in light of the totality of the

circumstances and may be based on inaccuracies or falsehoods that do not “go[] to

the heart of the applicant’s claim.” 8 U.S.C. § 1158(b)(1)(B)(iii).1 Cadena Chunza

omitted from his asylum application several significant incidents involving

FARC’s threats against him and his family. He failed to provide plausible

explanations for why those omissions occurred and merely stated his belief that all

of those specific events were encompassed by his application’s general referenceagreed with the IJ’s adverse credibility determination. The IJ and the BIA

presented “specific, cogent reasons” in favor of an adverse credibility

determination. See Forgue v. United States Att’y Gen., 401 F.3d 1282, 1287 (11th

Cir. 2005). Thus, the BIA did not err in finding that Cadena Chunza’s testimony

lacked credibility because of the material omissions in his asylum application. See

id. (holding that an asylum application’s omission of specific events of alleged

persecution is enough to support an adverse credibility determination).

      Substantial evidence in the record as a whole supports the BIA’s denial of

Cadena Chunza’s asylum application based on its adverse credibility

determination. See Forgue, 401 F.3d at 1287–88. Because Cadena Chunza “has

failed to establish a claim of asylum on the merits, he necessarily fails to establish

eligibility for withholding


a.m., Trump wrote: "The MAKE AMERICA GREAT AGAIN agenda is doing very well despite the distraction of the Witch Hunt."

Sekulow appeared on NBC's "Meet the Press," CNN's "State of the Union," CBS's "Face the Nation" and "Fox News Sunday" on Fox. Rubio spoke on NBC, CNN and CBS. Schiff spoke on ABC's "This Week"and King spoke on NBC.Select rating Poor Okay Good Great Awesome Your rating: None Average: 3.8 ( 9 votes)

Results have been released from an Anthropomorphic Research Project survey of 455 furs taken at Furry Fiesta 2013.

78% of females and 96% of males report viewing furry porn. Both groups underestimated both figures by 8-12%.

Increasing furriness indicated a tendency to use fantasy for various purposes, including escapism, but didn't indicate blurring of reality, or an inability to have fun, self-motivate, fulfil needs, socialize, or cope with problems without fantasy.

Female furs had less sexual roleplay, owned less pornography, viewed it less frequently, and felt it had less influence on their joining the fandom. They also saw pornography as more openly discussed within the fandom.

Furries overestimated the positivity of both male and female furs towards furry


overly-sexualized, and believe female furs are more positive about pornography than they actually are, leading to the feeling that they do not belong within the fandom — hence they don't join, or depart.

Both male and female furs were believed to be more positive about furry pornography than they actually were.

More than a third of furries have relatively negative attitudes […] and only about a quarter of furries feel quite positively toward it.

Male furs were more likely to view furry porn than female furs (t(49.0) = -2.87, p = .006). Males and females agreed on non-furry pornography

There was no significant difference between the groups when asked if they preferred pornographic or non-pornographic furry artwork. Over 50% preferred pornographic furry art (vs. ~17% for non-pornographic), but both preferences were typicallynot currently own a pet, while nearly half of furries said that they owned one or two pets.

The team hypothesized that those who wished to own a pet (and had in the past) might not be able to due to their current living arrangements.

In email, Nuka revealed findings relating to the anthropomorphism of animals (as compared to objects such as robots, cars and computers):

Those identifying more strongly as furries tend to anthropomorphise animals more (B = .29, p < .001) …but not as much as those identifying as therians (t(79.1) = -3.24, p = .002)

Those identifying as furries do not anthropmorphise all objects more than usual (B = .09, p = .33), …but do tend to anthropmorphise stuffed animals (B = .12, p = .048)

Lists of things to


scanning exposures the transmission can be anywhere between these extremes.
A static exposure starts with the variable attenuator at its maximum transmission. As the integrated dose increases, the dose control algorithm evaluates whether the next pulse (including its inherent energy error) will still fit within the dose ready window. If so, the next pulse will be fired. If not, the exposure is briefly interrupted to move the variable attenuator from the maximum to the minimum transmission. From this point on, the exposure is finished with low-energy pulses until the integrated dose fits within the dose ready window.
Since not all parts of the die are exposed simultaneously during a scanning exposure, the variable attenuator cannot be used in the same way, as different pulses affect different parts of the die.holding in the Astor House Hotel.

Captain Harry Morton (1915–1920)

Despite some shareholder opposition, in March 1915, Captain Henry "Harry" Elrington Morton (born 12 May 1869 in Clonmel, Ireland; died 2 October 1923 in Manila) a "staunch Britisher" who had become a naturalised American citizen, a master mariner who had first gone to sea at age 14, formerly of the Royal Navy, a Royal Arch freemason, who "had been coming to Shanghai for twenty years", was appointed managing director, with responsibility for managing Central Stores' three Shanghai hotels, including the Astor House, with a salary of $900 a month, plus board and lodging. Morton was "a retired ship captain who ran it as a ship, the hotel had corridors painted with portholes and trompe l'oeil seascapes and rooms decorated like


The Hotel "became the city's premiere destination for independent travellers seeking dormitory accommodation." One 1983 guide described the Hotel as "slightly run-down", while  a 1986 guide warned: "Despite its exceptional location near the Bund, ... the Pujiang is recommended only to travelers well prepared for 'roughing it'". Pamela Yatsko, who stayed at the Pujiang Hotel in 1986, described it as "a dilapidated western architectural relic catering to penny-pinching backpackers like myself, melted seamlessly into this somber skyline, making it barely distinguishable from a distance....As for the Astor House Hotel's spacious rooms, the renamed hotel rented me a cot in one that had been converted into a dorm room fitting probably 30 beds....The clerk charged me the equivalent of US$8 a night for the cot."

In 1988 the PujiangHotel was incorporated into another government-controlled entity, the Shanghai Hengshan Mountain Group (上海衡山集).

At that time, one assessment indicated: "Today the Pujiang is run down and can get cold and clammy in winter - otherwise its nice." At the end of 1989, the Pujiang was "Shanghai's official backpackers' hangout," with at least eight dormitories accommodating twenty people in each. Accommodation in "the cheap if austere dormitory rooms", was inexpensive. In 1989, a bed in the dormitories was 17 renminbi, including breakfast, while four years later it had only increased to 20 renminbi per night, while a private room was 80.

In 1998 the Pujiang became the first Shanghai member of the International Youth Hostel Federation. By 1998, "its 80 [private] rooms cost $40 to $60" per night. Prior to its


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   establishment in the city of Columbus. One Philip Dreyer, a minor of the age of 17 and a resident of South Dakota, had, along with Allen Aden, aged 22 and also a resident of South Dakota, been hired by law enforcement officials as undercover agents in an investigation of drug law violations in the city of Columbus. On June 17 and 18, 1971, both agents entered the plaintiff's establishment and on each occasion the plaintiff dispensed beer to Dreyer. Dreyer and Aden both testified that the plaintiff's employees made no inquiry concerning Dreyer's age nor did they ask for identification and proof of age. Dreyer and Aden described the waitress who served them.
Witnesses for the plaintiff were Alford Cluver, the sole stockholder of the plaintiff, and his daughter,


Nature Notebook – Salamander Shedding

We recently found one of our tiger salamanders writhing and contorting. It seemed to be experiencing a slow motion seizure. A few moments later, it crawled out of its skin. We had just witnessed a salamander molt.

Salamanders, like all amphibians, molt (shed their skin) several times throughout their lifetime, more so as juveniles when they are rapidly growing. Each species has an internal clock that determines the frequency of its molts. Temperature and light changes in its environment may influence this rhythm. However, hormones control the process.

The pituitary gland secretes a hormone that causes the thyroid gland to release another hormone. The result is an increase in the secretion of the mucus that is present in the skin to keep it moist. The additionalsupremacist. Julián Castro was the youngest member of Obama’s Cabinet, where he served as secretary of housing and urban development. Prior to joining the Obama administration, Castro was mayor of San Antonio, Texas, from 2009 to 2014. He is also the identical twin of the head of the Hispanic Congressional Caucus, Joaquin Castro, who just led a delegation to the border detention centers and child jails.

Well, Secretary Castro, welcome to Democracy Now! It’s great to have you with us. Let’s start off by talking about this vote that’s about to happen in the House right now condemning Trump’s racism as he singles out these four women of color and tells them to “go back” to where they came from. Can you respond?

JULIÁN CASTRO: I’m glad to see that


so many congressional representatives are stepping up today and condemning President Trump’s racist language.

This is nothing new for this president. We know that he launched his campaign by inciting racial division. And this is called racial priming. We haven’t seen a politician in a long time who has built his career on hate and bigotry and trying to divide people along racial and ethnic lines, as this president has, whether it was failing to immediately condemn those neo-Nazis in Charlottesville early in his tenure or talking about the inability of a judge to do his job because, quote, “he’s Mexican,” or the way that he started off his campaign, by saying that Mexico was sending drug runners and rapists, and that maybe some of them were also goodor housing. And that’s what’s missing in this administration. You can see that when you look at these images of men kept basically in cages and children not given toothbrushes or soap or basic things that they need, and separated cruelly from their parents. We need to return to a basic respect and compassion for people that is sorely missing right now.

AMY GOODMAN: Secretary Castro, what made you decide to run now for president, as opposed to, for example, running for senator from Texas, perhaps, against Senator [Cornyn]?

JULIÁN CASTRO: Yeah, a couple of things. First, that my experience is originally as mayor of San Antonio, in local government, and then as secretary of housing and urban development, as a federal executive. And so I see my experience as


deficient ramus, likely treated with distraction osteogenesis; T2), (C) severe---adequate mandibular body bone stock (ramus rudimentary or absent, adequate mandibular body bone stock to support costochondral graft), or (D) severe---inadequate mandibular body bone stock (ramus rudimentary or absent, inadequate mandibular body bone stock that necessitates free fibular flap).](gox-4-e598-g002){#F1}

Validation of Classification
----------------------------

Patients with a diagnosis of CFM were identified from our prospective craniofacial patient registry, following study review and approval by the institutional review board at the Children's Hospital of Philadelphia. Radiographic records were reviewed, and CT scan data retrieved. CT scans were included if they were performed before any mandibular surgical treatment and of sufficient fidelity to enable fine resolution 3-dimensional (3d) reconstruction. For patients with multiple CT scans meeting inclusion criteria, the scan at oldest age was utilizedto enable the broadest distribution of patient ages in our sample. The 3dCT reconstructions of the bilateral mandible and skull base in anteroposterior, lateral, and submental views were assembled for each patient and deidentified. The image sets were then loaded onto an online survey platform (SurveyMonkey, Palo Alto, Calif.)

Evaluators were identified from membership in the International Society of Craniofacial Surgery and were selected to represent a range of experience and practice locations. Demographic information for each evaluator was collected including type of training, location, experience, number of patients with CFM seen per year, and CFM classification system used in clinical practice. An attempt was made to capture evaluators from our previous investigation on interrater reliability of the Kaban modification of the Pruzansky classification^[@R22]^ to control for intrarater variability