may extend this timeframe in very limited situations.

Consult a Los Angeles Attorney to Seek Compensation for a Motorcycle Accident

Discussing the details of your motorcycle accident with a knowledgeable attorney can help in understanding your options under California law. Los Angeles lawyer Vann H. Slatter knows that motor vehicle collision victims have important rights to assert. He can work diligently to pursue your claim, while answering any questions you may have about the legal process. We are proud to serve residents of Lancaster, Norwalk, Van Nuys, South Gate, Palmdale, and many other Southern California cities. To schedule a free consultation, call our office at (310) 444-3010 or contact us online.see his wife and daughter. Dinardo was convicted and was sentenced to 25 years' to life imprisonment. At sentencing, the judge suggested to Dinardo that his sentence could be reduced were he to testify against Murdoch. Dinardo agreed and received in return a reduction of his conviction to voluntary manslaughter and a reduced sentence of 12 years' imprisonment.

5
Dinardo was a key witness at Murdoch's trial. He testified that, in 1983, Murdoch had approached him "to do a job" and that the two of them, together with two other men, robbed the Horseshoe Bar. According to Dinardo, when they entered the bar, Murdoch carried a .22 caliber rifle and announced loudly, "Don't nobody move. This is a stick-up." Dinardo took this as his cue to empty the cash register.


702. We concluded that if the contents of Dinardo's letter "are as generally described by the prosecutor and as Murdoch believes," then Murdoch "has arguably met his burden" of showing that the jury might have received a significantly different impression of the witness' credibility had Murdoch been able to pursue his proposed line of cross examination. Id. at 705. General impeachment for bias implicated Dinardo's reliability to a lesser extent than actual statements inconsistent with his testimony, such as those which the letter purportedly contained. Id. Without knowing the contents of the letter, however, we could not make a determination of whether Murdoch's confrontation rights had been violated. We accordingly remanded the case to the district court with instructions that the court obtain the letter, inspect it injail in Long Beach, California.

34
This is my reconstruction of the letter that Dinardo sent to his counsel as he awaited trial:

35
I would like to make a statement about the facts surrounding my arrest for robbery and murder. I was taking care of my young daughter when Long Beach police arrested me at my home in Berkeley. Two policemen, Detective Pavek and his partner, took me to the Berkeley Police Department and interviewed me. I wanted to get back to my daughter as I worried about her welfare. At that time, Detective Pavek coerced a statement from me and promised not to charge me if I made a statement that Charles Murdoch participated in the crime. But, I do not actually know Mr. Murdoch, although I know his brother.


against legalization and remains personally opposed to it, isn't yet taking a position on Brnovich's idea. He wants to see what the marijuana industry proposes.

He has, however, expressed concern about the fact that laws passed by voters cannot be changed if unanticipated circumstances arise.

"Gov. Ducey was a strong opponent of the 2016 measure," his chief of staff, Daniel Scarpinato told me. "He (has) reiterated his opposition to recreational marijuana, and said he wants to see the specific language of any new measure before commenting on it."

Brnovich is trying to get ahead of the pot-fueled freight train coming our way given changing public sentiment about marijuana legalization. He knows that if voters approve the coming initiative, legislators probably will be unable to fix any problems that arise as aballot for voters to consider if the industry proposal is lacking.

Legislators ought to be able to regulate the potency of recreational marijuana, as The Republic’s Robert J. Robb recently suggested.

They ought to have the flexibility to determine where pot can be sold before head shops pop up on every street corner and where it can be smoked, if that isn’t adequately addressed in the industry initiative.

And they absolutely must be able to pass laws to keep the roads safe.

An estimated 14.8 million Americans admitted to driving while high at least once in the past month, according to a recent study by AAA. Nearly seven in 10 say they had no worries about getting caught.

Nor should they worry since scientists haven’t yet figured out a way to measure marijuana


admission fee.

Eves and his assistant Shlaes handled most of the advance work, compiled the final invitation list, and managed each event, including the preparation of briefing books and itineraries. All fourteen conferences were heavily covered by regional and national press, whose comments were assembled by Eves and his assistants and forwarded to selected White House staff and the President. Other follow-up activities consisted largely of thank-you notes and mailings of conference transcripts.

John Shlaes joined the Public Liaison Office in December 1974 to help Eves. After January 1976, Shlaes acted effectively as co-director in arranging a series of White House conferences on President Ford's proposed consumer representation plans. The nine conferences in January, chaired by presidential special assistant Virginia Knauer and cabinet secretaries, were designed to air President Ford'sin bohol grinding mill china small size stone crusher price in india bohol is a first income class island group province of the philippines located

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promise in writing made by one person to another, signed by the maker, engaging to pay on demand, or at a fixed or determinable future time, a sum certain in money to or to the order of a specified person or to bearer.'

Additionally most Commonwealth jurisdictions have separate Cheques Acts providing for additional protections for bankers collecting unendorsed or irregularly endorsed cheques, providing that cheques that are crossed and marked 'not negotiable' or similar are not transferable, and providing for electronic presentation of cheques in inter-bank cheque clearing systems.

History
In India, during the Mauryan period in the 3rd century BCE, an instrument called adesha was in use, which was an order on a banker desiring him to pay the money of the note to a third person, whichstates that these conditions may be disregarded.
If a note or draft is negotiated to a person who acquires the instrument
in good faith;
for value;
without notice of any defenses to payment,
the transferee is a holder in due course and can enforce the instrument without being subject to defenses which the maker of the instrument would be able to assert against the original payee, except for certain real defenses. These real defenses include (1) forgery of the instrument; (2) fraud as to the nature of the instrument being signed; (3) alteration of the instrument; (4) incapacity of the signer to contract; (5) infancy of the signer; (6) duress; (7) discharge in bankruptcy; and, (8) the running of a statute of limitations as to the validity of the instrument.
The holder-in-due-course rule is


wonder 100 percent Kona Coffee is so revered—it was a cup of silky smooth perfection at $5.95. No bitterness whatsoever, and at a great price considering the quality.

The first taste gave us goosebumps, the kind of body rush we’d been looking for in heavier caffeinated blends, but without the shakes.

“I love pour-overs,” says Sheperd-Hall. “The barista gets to choose how the coffee is made—the saturation, the filter, everything. Otherwise, I have no control.”

Biggest perk: Most variety and new to the downtown scene.

207 S. King Street, 537-3415, kaicoffeehawaii.com

Local Joe

You can order the Cubano from Local Joe, which recently opened in Chinatown, with any image you want in the foam.

Local Joe is an unassuming coffee joint in Chinatown just behind O’Toole’s Irish Pub—though it’s not open late enough to helpHead Start experience for their children.

21
We therefore conclude that the federal regulations authorizing the PPC, specifying its composition, and giving it authority to approve firing decisions do not support a finding that the PPC's decisions can be fairly attributed to the federal government.  See, generally, Broad v. Sealaska Corp., 85 F.3d 422, 431 (9th Cir.1996) (holding that "[w]ithout governmental encouragement or coercion, actions taken by private corporations pursuant to federal law do not transmute into government action"), cert. denied, --- U.S. ----, 117 S.Ct. 768, 136 L.Ed.2d 714 (1997);  Mathis v. Pacific Gas and Elec. Co., 75 F.3d 498, 501 (9th Cir.1996) (requiring a showing that federal regulations created the "standard of decision" for the personnel decision of a private entity to be considered governmental action);


is completely barred by the terms of the statute, we find that her claim is "unreasonable" and "meritless."   See Franceschi v. Schwartz, 57 F.3d 828, 832 (9th Cir.1995);  Vernon v. City of Los Angeles, 27 F.3d 1385, 1402 (9th Cir.1994).  Morse has not alleged any actions by NCO which could be attributed to the State of California.  We therefore grant NCO's request for attorneys' fees on appeal under § 1988 as the prevailing defendant in a § 1983 civil rights suit.  Determination of reasonable attorneys' fees is transferred to the district court.

29
The district court's order is AFFIRMED.  Appellant's request for attorneys fees is DENIED.  Appellee's request for attorneys' fees is GRANTED and the matter is REMANDED for further proceedings.

1
 AlthoughSWAT Standoff Ends Peacefully

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enhanced manufacturing, specifically in the situation of horizontal wells. These new devices permit casings to run to the lateral zone with correct packer/frac port placement for optimal hydrocarbon recovery.

In a cased-gap completion, tiny holes referred to as perforations are made while in the portion of the casing which handed with the generation zone, to supply a path with the oil to stream within the encompassing rock in to the manufacturing here tubing. In open gap completion, normally 'sand screens' or simply a 'gravel pack' is set up in the final drilled, uncased reservoir section.

Increased Restoration techniques including drinking water flooding, steam flooding, or CO2 flooding may be made use of to extend reservoir tension and provide a "sweep" outcome to push hydrocarbons out on the reservoir. These kindsthe first three pages here a complete waste?

Whilst we're on the subject of letter pages, I should note that the responses there make it clear that Bryne has put a lot of work into ensuring these stories fit seamlessly into continuity (they note, for example, that Lorna can't be referred to as Polaris at any point because she's given the name by Erik the Red in UXM #97). Obviously, I stand and salute this noble endeavour. Indeed, although some of the actual distances involved still make no sense, it's clear Byrne is working to a carefully constructed timeline. That's exceptionally thoughtful of him. Shame his stories are such guff.

Having said that, this is probably the best issue produced so far. It's certainly better paced than usual. It also


got even. He led a battle for Chrysler's survival that made his name a symbol of integrity, know-how, and guts for millions of Americans.

In his classic hard-hitting style, he tells us how he changed the automobile industry in the 1960s by creating the phenomenal Mustang. He goes behind the scenes for a look at Henry Ford's reign of intimidation and manipulation. He recounts the miraculous rebirth of Chrysler from near bankruptcy to repayment of its $1.2 billion government loan so early that Washington didn't know how to cash the check.will, but that seems to be Nancy Pelosi's gambit at this point."

House Democrats passed two impeachment articles — abuse of power and obstruction of Congress — through the lower chamber on Tuesday. Impeachment proceedings began almost three months ago when a whistleblower filed a complaint to the House over the president's dealings with Ukraine.


/*! Destructor */
  virtual ~FrsImage()
  {
  }

  /*! Returns the width of the complete image */
  inline unsigned width() const
  {
    return _width;
  }

  /*! Returns the height of the complete image */
  inline unsigned height() const
  {
    return _height;
  }

  /*! Returns the gray value for pixel x,y */
  virtual float pixel(unsigned x, unsigned y) const = 0;

  /*! Sets the array.
   *  \param array:
   *    The array containing the values we wish to store.
   *    Its size is sw*sh.
   *  \param width:
   *    The widthand work on
   *  \param sh:
   *    The height of the part of the image we want to store and work on
   */
  RGBImage(float *rgb, unsigned w, unsigned h, unsigned sw, unsigned sh, unsigned ox, unsigned oy)
      : FrsImage(w, h, sw, sh, ox, oy)
  {
    _rgb = new float[3 * _storedWidth * _storedHeight];
    memcpy(_rgb, rgb, 3 * _storedWidth * _storedHeight * sizeof(float));
  }

  RGBImage &operator=(const RGBImage &brother)
  {
    dynamic_cast<FrsImage &>(*this) = brother;
    _rgb = new float[3 * _storedWidth * _storedHeight];
    memcpy(_rgb, brother._rgb, 3 * _storedWidth * _storedHeight * sizeof(float));
    return


\param h:
   *    The height of the complete image
   *  \param sw:
   *    The width of the part of the image we want to store and work on
   *  \param sh:
   *    The height of the part of the image we want to store and work on
   */
  GrayImage(float *lvl, unsigned w, unsigned h, unsigned sw, unsigned sh, unsigned ox, unsigned oy)
      : FrsImage(w, h, sw, sh, ox, oy)
  {
    _lvl = new float[_storedWidth * _storedHeight];
    memcpy(_lvl, lvl, _storedWidth * _storedHeight * sizeof(float));
  }

  GrayImage &operator=(const GrayImage &brother)
  {
get the solution is: $$f(x,t)=F1(x)\cdot F2(t)$$ where $F1$ and $F2$ are functions such that $$F1_{xx}=c_1\cdot F1-(a\cdot x^2-b)F1_x \quad\text{ and } $$$$F2_t=c_1\cdot F2, $$ where $c_1$ is an arbitrary constant. The ODE for $F1$ has an "explicit" solution in terms of the Heun Triconfluent function (very ugly! Maple is not making some simplifications because it is assuming a and b are complex numbers) and the second ODE is just $F2(t)= c_2 \exp(c1\cdot t)$.
$F1(x) = c_3\cdot HeunT\left(-3^{2/3}\cdot a^2\cdot c_1/(a^2)^{4/3}, -3\cdot \sqrt{a^2}/a, a\cdot b\cdot 3^{1/3}/(a^2)^{2/3}, (1/3)\cdot 3^{2/3}\cdot (a^2)^{1/6}\cdot x\right)\cdot \exp\left(-(1/6)\cdot x\cdot (a\cdot x^2+3\cdot b)\cdot ((a^2)^{1/6}\cdot a+(a^2)^{2/3})/(a^2)^{2/3}\right)+c_4\cdot HeunT\left(-3^{2/3}\cdot a^2\cdot c_1/(a^2)^{4/3}, 3\cdot \sqrt{a^2}/a, a\cdot b\cdot 3^{1/3}/(a^2)^{2/3}, -(1/3)\cdot 3^{2/3}\cdot (a^2)^{1/6}\cdot x\right)\cdot \exp\left((1/6)\cdot x\cdot (a\cdot x^2+3\cdot b)\cdot ((a^2)^{1/6}\cdot a-(a^2)^{2/3})/(a^2)^{2/3}\right)$


crime is that those allegedly responsible should be brought before the courts having jurisdiction for such matters in order that the accused may receive a fair trial.

Lord Fraser of Carmyllie My Lords, the noble and learned Lord has not quite answered the Question that I put to him. As the new Administration takes up office and as the noble and learned Lord as the new Lord Advocate takes over responsibility for these matters, it would be helpful if a clear signal were given not only to this country but also to the rest of the world that the policy pursued by previous Lord Advocates will be maintained. Even in the absence of a clear answer from the noble and learned Lord, I hope I may ask him twoaccess to much information that was not available to me at that stage and which is not in the public domain. I can assure the House that I am satisfied on the information available to me that there is no reason not to proceed with the petitions. The noble and learned Lord will be aware that the situation is still fluid in the sense that if additional information becomes available any decision would have to be reviewed. I can also assure the noble and learned Lord that should it be decided that no prosecution will take place I shall return to the House and make a Statement to that effect.

1 comment:

Really. Some people, seeing themselves as way above the masses, spoke like that in Denmark too about a


the contract, or
    //   2.  the linked Service Pricebook Entry, or
    //   3.  the Standard Pricebook Entry from the Work Detail Line
    public static void UpdateLaborPN(List<SVMXC__Service_Order__c> triggerNew) {

    // Process only if 'Get Billing Part Nums' checkbox is checked.
    for (SVMXC__Service_Order__c wo : triggerNew) {
      if (wo.Get_Billing_Part_Nums__c != True) {
                          continue; // skip any further processing of this work order
      }
    }

     225 F.2d 16
NATIONAL LABOR RELATIONS BOARD, Petitioner,v.MONSANTO CHEMICAL COMPANY, Respondent.
No. 14472.
United States Court of Appeals Ninth Circuit.
July 27, 1955.

George J. Bott, Gen. Counsel, David P. Findling, Associate Gen. Counsel, Marcel Mallet-Prevost, Asst. Gen. Counsel, NLRB, Washington, D.C., Patrick Walker, Frederick U. Reel, Margaret M. Farmer, Washington, D.C., for petitioner.
Elton L. French, St. Louis, Mo., Alfred J. Schweppe, Seattle, Wash., Peter W. Bauman, Jr., ,.st. Louis, Mo., for respondent.
Before STEPHENS, HEALY and POPE, Circuit Judges.
POPE, Circuit Judge.

1
The General Counsel of the above named Board filed a complaint against respondent charging it with unfair labor practices within the meaning of § 8(a) (1) of the National Labor Relations Act.1  The complaint arises out of the refusal of the respondent to permit the representatives of a labor union to distribute


sign was placed at this location, yet because there was little traffic on the highway, most of the employees' automobiles did not stop there.  Hence on this occasion as on previous occasions when distribution had been attempted at this point by the union representatives they found little or no opportunity to distribute their literature for the employees simply drove past without stopping.  It is conceded that the respondent had and expressed no objection to the distribution of literature on the private road and at that highway intersection.  Later the two union representatives returned to the parking area and commenced distribution of literature there.  They were then approached and ordered to leave the place and they did so.  Again they attempted to distribute literatureThere is reason to assume that the court treated that as a case involved distribution of literature by employees for it cited as authority for its decision the Le Tourneau case, supra, without any suggestion that the facts presently before the court were any different than those there involved.4

11
In some cases clearly distinguishable from the one before us it has been held that under § 7 of the Act, a union organizer who is not an employee cannot be denied the privilege of entering and soliciting union membership on the employer's premises.  In National Labor Relations Board v. Stowe Spinning Co., 336 U.S. 226, 69 S.Ct. 541, 93 L.Ed. 638, the prohibition which was pronounced an unfair labor practice stemmed from the fact that the employer was


so much so, that he was actually planning to take an unofficial visit down to Texas this past Sunday following his Baylor trip but it simply got to be too late.

Powell was expected to make a decision in the next week or so and it was thought he’d pick Ohio State. But he says he will likely push that back and added that he plans on taking official visits to Oklahoma and Texas.

He is also trying to take an unofficial visit down to Texas in the next few weeks, if possible. He mentioned that he had hoped to be in Austin yesterday but had a team conflict.

If he does indeed push this back, I suspect this one turns into a Red River battle.

For Texas, I imagine they seeroom, to be honest with you. We get along great and there are very defined roles in who’s responsible for what… I expect us to run the ball better for a variety of reasons. Whether that’s us as coaches coaching them better and focusing on schemes that fit the talent level, the development of our offensive line and our tailbacks, the health of our tight ends and the fact that we have tight ends now, and — hopefully — the development of our pass game…”

Tom Herman says that the game planning is a group effort (eh…) and that it doesn’t matter who calls the plays (I agree)

LB Gary Johnson

Gary Johnson told us he rotates between both Mac and Rover in case someone goes down.

On that note, the LB


to tell me where the restroom is, too, cos I'm deathly ill, actually, and ready to throw up at any moment, so..." " It's right across the hall." " Great." "I'm not joking." "MAN 2:" "We're ready to go, gentlemen." "New York's waiting for a shot of him." "If you see in my eyes, I've been crying just a little bit." "And it seems really ridiculous because I've never met the man." "I know life is ephemeral, but I just, you know," "I expected him to be around a little longer." "Pretty sure everybody did, but, you know..." "The thing I'm using right now, an iMac, he made." "He made the iMac." "He made the Macbook." "He made the Macbook Pro." "He made the Macbook Air." "He madethe iPhone." "He made the iPod." "Yeah, he's made the iPod Touch." "He's made everything." "♪ Hey, Mr Tambourine Man Play a song for me" "♪ I'm not sleepy And there's no place I'm going to" "♪ Hey, Mr Tambourine Man Play a song for me" "♪ In the jingle jangle morning I'll come following you" "WOMAN 1:" "It's not often that the whole planet seems to feel a loss together, but after the death of Steve Jobs, co-founder of Apple and singular dreamer, all day, we watched as there was a kind of global wake." "On Facebook, millions changing their profiles to the Apple logo." "A kind of black armband, a gesture of gratitude." "WOMAN 2:" "We've been monitoring the hashtag "thankyousteve."" "MAN:" "My favorite tweet last


Dylan maybe because he wasn't just one thing." "He was a storyteller who could be whatever we wanted him to be." "I don't even what know what All Along The Watchtower means." "I think it is one of the most beautiful, haunting, brilliant pieces of poetry ever." "And to me, it's like Steve." ""There must be some way out of here, said the..."" "(CHUCKLES) What is it?" "Said the Joker to the Thief." "He's both." "♪ "There must be Some way out of here"" "♪ Said the joker to the thief" "♪ There's too much confusion" "♪ I can't get no relief" "♪ Businessmen, they drink my wine" "♪ Plowmen dig my earth" "♪ None of them along the line" "♪ Know what any of it is worth"popular typewriter-sized computer on the market today." "MAN:" "Steve Jobs, I realize this is your baby, and you've made a career out of it, but you're also something of a philosopher." "Do you see the inherent possibility of bad coming out of all of this?" "Well, I think one of the things you really have to look at is you have to go watch some kids using these things." "And what you find is far from something quite harmful." "In effect, what you see is an instantaneous reflection of a part of themselves, the creative part of themselves being expressed." "WOMAN:" "He was going for a computer that really felt like an extension of the self." "That's what people wanted, and I think he sensed that." "He knew


involved in his schemes." "He's seducing you, he's vilifying you and he's ignoring you." "You're in one of those three states." "(LAUGHTER)" "JOBS:" "When you get a core group of, you know, ten great people, it becomes self-policing as to who they let into that group." "So, I consider the most important job of someone like myself is recruiting." "MAN:" "Steve Jobs brought us all together in a place that had no rules." "He's a maniac." "He's a maniacal genius." "His job is to stir up everything." "JOBS:" "Most places in life are continuously telling you that your dreams aren't possible or practical." "You don't want to hear that when you're under 30." "What you want to do is race after them." "You ask yourself, why are you"And the first thing I thought I'd do is give you an update." "We've managed to go from losing a billion dollars the year before to actually making over $200 million during the first three quarters." "Boy, what a difference a year makes." "(CHUCKLES)" "Guess what?" "Mac is back." "♪ She comes in colors everywhere" "♪ She combs her hair" "♪ She's like a rainbow" "He was the kind of person that could convince himself of things that weren't necessarily true." "He could go to people and ask them to do something that they thought was impossible." "RUBINSTEIN:" "Steve did create reality distortion around him." "You know, if he told you the sky was green, for a while, you'd kind of go, "Yeah, OK." "Yeah, the sky's green.""


oh" "♪ You're changing your heart" "♪ Oh, oh, oh" "♪ You know who you are" "♪ One, two, three, four" "♪ Tell me that you love me more" "♪ Sleepless long nights" "♪ That is what my youth was for" "♪ Oh, teenage hopes" "NARRATOR:" "Jobs's genius was how he sold the iPod." "It wasn't a machine for you." "It was you." "JOBS:" "People sometimes forget that they're very unique and that they have very unique feelings and perspectives." "You know, the whole computer industry wants to forget about the humanist side and just focus on the technology, but we think there's a whole other side to the coin, which is what do you do with these things?" "Can we do more than just spreadsheets and wordthey're good, even if they're the best, enough to make the world a better place?" "MAN:" "Apple's a business." "And we've somehow attached this emotion to a business, which is just there to make money for its shareholders, right?" "That's all it is." "Nothing more." "You know, creating that association was probably one of Steve's greatest accomplishments." " PRODUCER:" "It's queued up to play." " Awesome." "("MARIMBA" RINGTONE PLAYS)" "I remember at this point, when the music plays in the beginning, there's just this energy, right?" "You have on the one side this huge bank of photographers, and I remember looking at all these guys with their cameras trained on Steve, thinking," ""You guys have no idea what's about to happen."" "And to be fair, neither did we."


iPhone, which shocked the world with its touch screen and stuff." "MAN:" "So, what are we down to?" "13 minutes and..." "Whoo-hoo!" " It's go time!" " Oh, yeah." " Oh, yeah." "Swipe to unlock." " Sweet!" "♪ All my life" "♪ Is changing every day" "MAN:" "There she is." "♪ In every possible way iPhone's been shipping for exactly 200 days today." "And I'm extraordinarily pleased to report that we have sold four million iPhones to date." "(CHEERS AND APPLAUSE)" "♪ Never quite as it seems" "♪ And then I open up and see" "♪ The person falling here is me" "Today we're introducing the iPhone 3G." "(CHEERS AND APPLAUSE)" "In a little over two years, we have sold 30 million iPhones." "(CHEERS AND APPLAUSE)" "MAN:" "Andwith a swipe, you have changed your life." "Yes!" " How may I help you?" " iphone 4." "Where is the iPhone 4?" "Oh, I'm very sorry, but we are currently sold out." "However, we did finally get some more HTC Evos in." "What?" "What is that?" "Is it an iPhone?" "No, it is that 4G phone on Sprint." "If it's not an iPhone, why would I want it?" "Well, it's similar to an iPhone, but has a bigger screen." "I don't care." "The internet speeds are around three times faster." " I don't care." " It fucking prints money." " I don't care." " It can grant up to three wishes." "Even if one of those wishes is for an iPhone." " I don't care about any


of that." " OK, fine." "Then what the hell entices you about the iPhone 4, if you don't mind me asking?" "It is an iPhone." "TURKLE:" "I remember the first set of people I interviewed about the iPhone." "I've been interviewing people about their computers for, you know, decades." "I've never seen this kind of connection before with an object." "In the beginning, the impulse was to sit you down and to show you everything on their iPhone." "As time's gone on, there's been less of that and more of what I call the "alone together phenomenon."" "It has turned out to be an isolating technology." "PRODUCER:" "Did you ever see that Wim Wenders film," ""Until the End of the World"?" "TURKLE:" "Yes, I love that." "People fall"NARRATOR:" "To make those option deals even sweeter, companies would allow executives to buy stock on dates in the past when the price was low so executives could make millions in the blink of an eye." "This was called "backdating."" "And it seemed like the perfect solution, except for one thing." "If not properly reported, backdating is illegal." "200 US public companies are under investigation over charges of backdated stock options for their senior executives." "NARRATOR:" "Backdating was a dicey game, and it landed several executives in jail for fraud, but it became a frequent practice at Apple under Jobs." "ELKIND:" "Apple eventually conducted an internal investigation and found thousands of cases where stock options had been handled inappropriately." "None of that had taken place according to the


1:30 in the morning." "Soon after, security cameras spotted him in an elevator in his apartment complex." "He got out on the 12th floor and texted his girlfriend." "At 3:33am, security cameras recorded Sun Danyong jumping to his death." "KANE:" "Over a period of two years or so, there were 18 suicides." "Foxconn set up these nets to catch people who fall off." "People were jumping off of the buildings, so they were going to prevent people from dying by having safety nets to catch them." "You know, they've had, if you count the attempted suicides, 13 so far this year." "And while that is still..." "They have 400,000 people at this place." "So, 13 out of 400,000 is 26 per year so far." "For 400,000 people or,you know?" " (LAUGHTER)" " MAN:" "Really?" "So somebody should make a movie out of this." "NARRATOR:" "If you were to make a movie about it, the first scene would be set in a beer garden in Silicon Valley." "As he swilled a few steins of Pilsner," "Apple's Gray Powell was testing out a new iPhone prototype." "But when Powell staggered out of the bar, he forgot one thing." "The iPhone." "It was found on a bar stool by a college student named Brian Hogan." "MAN:" "And this e-mail comes into our tip box, and there was this guy claiming that he had this new iPhone prototype." "Getting inside Apple's security fort, and look at something that is under wrap." "But back then, when Steve Jobs was at


was halted for a time, then took a big hit when it re-opened in after-hours trading." "WOMAN:" "Apple's share prices have dropped with every pound that Jobs has lost in recent months." "KANE:" "Apple really landed into a dicey situation when Steve decided to issue a letter saying," ""Well, you know, nothing's wrong with me."" ""It's just a minor problem," And it wasn't a minor problem." "ELKIND:" "Steve Jobs made a point of withholding from the world that he faced this illness." "That's something investors want to know, because when you bought Apple stock then, you were buying into Steve Jobs." "He was obligated to tell shareholders right away about this serious illness." "KANE:" "You do personally want to give Steve the privacy, but Steve put the spotlightservices such as rugs and upholstery, area rugs and carpet, curtains and carpets, ovens and rugs, mattresses and carpets cleaning to add up or to exceed the minimum amount to get the best value.

In addition, parking fee in Balham and traffic congestion charges may apply.


least at 10 HZ and 65 Hz. Higher stimulation frequencies and preloads result in a more quickly contracting muscle, which generates more pressure. Midrange stimulation frequencies of 30 Hz provide optimal muscle strength and minimize time to develop peak pressure. Initiation of contraction should begin before the time maximal pressure is desired.Mark:  Thus far, I have uncovered only one "nondocumented" electronic
agreement.  The equity desk uses the services of POSIT which is an electronic
trading system which matches orders six times daily for institutions and
broker dealers.  There is no agreement for this matching service.  I am not
aware of other "matching services" and whether any agreements are in place.
Let me know if you have any concerns.  Thanks.  Sara


4B Board considers pro management option

Published 5:17 pm, Thursday, July 1, 2010

The Midland Footaball, Soccer & Baseball Complex Development Corp. wants to increase revenues and improve the balance sheet at the Scharbauer Sports Complex.

The panel, commonly known as the 4B Board, will consider advertising for bids from professional sports management companies.

A meeting on July 7 will be held at City Hall to discuss the matter. The meeting is scheduled for 4 p.m.

Ken Marks, president of the 4B Board, adjourned a Wednesday meeting when too few members showed up to achieve a quorum. He said board members feel they have lowered expenses as much as possible and now need to operate the complex on a more commercial basis.

Marks said that while the panel is pleased with work done forthe complex by the Chamber of Commerce and its director of sales and marketing, Nancy Swallow, the six 4B members "want to put the proposal out there and see what comes of it."

"Nancy and the Chamber have done an excellent job, but other people might have different ideas on how to use the complex," he said. "The city has concerns and we have cut expenses."

Only City Councilman John James, a 4B director, and Marks were on time for the 4 p.m. meeting. Michael Dobey arrived at 4:20, but City Director of Community Development Monette Burke said Wesley Bownds was on a conference call and Cary Billingsley was unavailable.

It was known beforehand that the vacationing Jim Smith wouldn't take part, Burke said.

Marks said that with a fund balance of


Angiography is a procedure used in the diagnosis and treatment of cardiovascular conditions including abnormalities or restrictions in blood vessels, the network of passageways through which blood travels in a human or animal body. During angiography, a radiographic contrast material is injected through a catheter into a vein or artery, which then passes to vascular structures in fluid communication with the vein or artery. When X-rays are passed through the region of the body into which the contrast material is injected, they are absorbed by the contrast material, providing radiographic images of the desired vascular structure(s). The images can be recorded on film or video tape and/or displayed on a fluoroscope monitor. The images can be used for many purposes, as for example, diagnostics and for therapeutic proceduresthe podcast at 6:30, because I had social writing plans for the evening, and I hadn’t eaten dinner yet. I gulped down some chicken fried rice that T– made (which was delicious), and finished it just before D– showed up to give me a ride to Full Circle.

When we got there, we found the coffee shop packed. At first we assumed it was a book signing, but several people were wearing name tags, and as we lingered in the other room we heard frequent bursts of applause. That doesn’t sound like any book signing I’ve been to. Probably some sort of…I don’t know, corporate event.

Anyway, it was a nuisance, but we found reading chairs elsewhere in the bookstore, and D– spent his time working on a project for


University of Wisconsin-Parkside, School of Business and Technology

The University of Wisconsin-Parkside is located in the vibrant economic corridor between Milwaukee and Chicago. Set on 700 acres of natural prairie and woodland, students live in a rural setting but have easy access to the cultural and business activities in these larger cities. Many global companies are headquartered in the region including Harley Davidson, SC Johnson, Snap-on Inc., Northwestern Mutual, and Abbott laboratories. The College of Business, Economics, and Computing prepares students to become business and community leaders in a range of fields and organizations. The college offers undergraduate business programs in Accounting, Finance, General Business, Human Resource Management, Management Information Systems, and Marketing. Several certificates in areas such as project management and sales are also available. Students in SalesDelhi High Court puts on hold JNU action against Umar, Anirban

New Delhi: Delhi High Court today put on hold the disciplinary action taken by JNU administration against students Umar Khalid and Anirban Bhattacharya, accused of sedition in connection with a February 9 event, till their appeals against the decision are decided by the university’s appellate authority.

Justice Manmohan granted the protection to both the students who have sought the same relief that was given on May 13 to Jawaharlal Nehru University Students Union (JNUSU) President Kanhaiya Kumar and others against whom disciplinary action was taken by the varsity after the row over the February 9 event this year.

“This court is of the opinion that the petitioners (Khalid and Bhattacharya) are entitled to same order as passed by this court


Smoking, exposure to secondhand smoke, and smoking restrictions in Tijuana, Mexico.
To estimate the prevalence of tobacco use, exposure to secondhand smoke, and smoking restrictions in the home and workplace among residents of Tijuana, one of Mexico's largest cities. This cross-sectional household survey was conducted in Tijuana, Baja California, Mexico, during 2003 and 2004. A population-based sample of 400 Tijuana adult residents responded to a tobacco survey, and 397 of the surveys were analyzed. About 22.9% (95% confidence interval (CI): 18.7%-27.1%) of Tijuana adults reported current smoking, and 53.9% (95% CI: 48.8%-58.9%) reported chronic exposure to secondhand smoke. Approximately 44.4% (95% CI: 37.9%-50.9%) of Tijuana adults had a nonsmoking policy in their workplace, while 65.8% (95% CI: 61.0%-70.6%) of Tijuana households were smoke-free. The results underline the need forin 1946, at the end of the second world war, it is conservative, pro-establishment and pro-monarchy. It is the party of the Bangkok elite who control all of the wealth and, crucially, is supported by heads of the Thai Military.

Red Shirts v Yellow Shirts – Left v Right

Having failed to win the votes of the poor people, which is the majority, the Democrats had also failed to win an election for two-decades prior to 2008. That was the year their army intervened and sent the democratically elected Red Shirts running up the hill.

Shinawatra was chased into exile and, with the party either in disarray or in prison, the democrats, the Yellow Shirts, the party of the army, won the new election and their leader, Abhisit Vejjajiva, became Prime


report some pertinent information here. Pregnant women from the Igbo tribe -- a large ethnic group of eastern Nigeria -- were recorded as the main users, and comments were made on the effectiveness of the ingested soils/rocks in limiting vomiting during pregnancy and reducing over-salivation`: `there is no suggestion that the Calabash chalk is being consumed to aid mineral nutrient supplementation. The daily amount consumed varies, but generally is c. 5--10 g. However, differences are apparent between pregnant and non-pregnant women: the former tend to ingest more (up to 20 g/day) with consumption occurring either before or after mealtimes to prevent vomiting, whereas the latter consume soil generally when in a fasted state. For both groups of women, consumption occurs by gnawing chunks of the geophagical material.

The Undongopseudo-total (i.e., an approximation) rather than true total concentrations. However, our use of fine (i.e., \<150 µm) material in this experimental procedure facilitates sample decomposition and optimises the release of chemical elements into solution. Analysis of the sample solutions was undertaken using inductively coupled plasma mass spectrometry (ICP-MS) for six soil trace elements (Cd, cobalt \[Co\], chromium \[Cr\], Cu, nickel \[Ni\] and Pb), whilst another trace element, Zn, and a number of major (Ca, Fe, potassium \[K\], Mg) and minor (Mn, sodium \[Na\]) elements were determined by atomic absorption spectrometry.

2.4 Determination of Bioaccessible Concentrations {#s2d}
-------------------------------------------------

For our assessment of the bioaccessible concentrations, we used the Fed ORganic Estimation human Simulation Test (FOREhST) procedure. This method was initially developed to assess the bioaccessibility of soil polycyclic aromatic hydrocarbons (PAHs, widespread


fed-state experimental procedure that is appropriate to use since the main consumers in this investigation are pregnant women who ingest the geophagical materials just before or after mealtimes, and (II) assessed using the FOREhST method where the food component of the *in vitro* procedure is omitted, but where other experimental variables (transit times, solution pH, enzyme concentrations) are the same as (I), so enabling the effect of food alone on bioaccessibility to be evaluated.

The FOREhST procedure is a IVBA test, carried out at 37°C to simulate human body temperature, and utilising end-over-end rotation that replicates the churning of soil and fluid in the gut. The stages involved in the methodology represent the saliva/gastric and intestinal (i.e., duodenal and bile) phases of the human GI system. Briefly (for awhich the bioaccessible guideline value of 13±6 mg Pb/kg is obtained.

Eight samples were replicated when undertaking the IVBA procedure in order to determine the precision of this analysis. However, because a number of solution concentrations were below the limits of detection, the reproducibility of analysis can only be quantified from a more restricted number of duplicated samples: [Table 2](#pone-0053304-t002){ref-type="table"} provides a summary of the precision estimates determined in our study.

10.1371/journal.pone.0053304.t002

###### Precision of analysis quantified from sample replicates subjected to the *in vitro* FOREhST procedure.

![](pone.0053304.t002){#pone-0053304-t002-2}


limit of detection which is 5.3 mg/kg). For the F-S scenario, again the majority of the leachate solution Zn concentrations are either below the blank solution contents or below the limits of detection (the latter are 1.2 mg/kg and 2.4 mg/kg for the saliva/gastric and intestinal phases of this scenario, respectively). However, one F-S leachate solution (Undongo, \<250 µm soil, saliva/gastric phase) yielded a detectable concentration of 4.7 mg Zn/kg.

For the remaining chemical elements (i.e., Co, Cr, Fe, Mn and Ni) considered in the bioaccessibility study, whilst a number of leachate solutions have concentrations below those of the blank solutions, many are above so indicating the potential of ingested soils/shales to be sources of these mineral elements that humans can subsequently absorb. [Tables 5](#pone-0053304-t005){ref-type="table"} and [6](#pone-0053304-t006){ref-type="table"} provide afor this metal is unknown (but could be as low as 5 µg/day [@pone.0053304-Nielsen2]);

values expressed as mg/day [@pone.0053304-EVM1];

GL applies to trivalent Cr (the naturally occurring valency state of this chemical element that is found in soils);

for guidance purposes, a supplemental intake of 17 mg/day would not be expected to produce adverse effects in the majority of people. This is based on data referring to the ferrous form of Fe;

GL for supplemental intake.

We are not the only researchers who have concluded that ingested soils are not a significant source of Fe to the geophagist. The *in vitro* work of Hooda et al [@pone.0053304-Hooda1] indicated how the sorption potential of some geophagical soils can lead to a reduction of Fe concentrations in the simulated GI fluids. These findings, however, contradict


The League of Legends community was in shock today after Cloud 9 defeated the European powerhouse Fnatic, winning the Battle of the Atlantic for North America. Analysts are still scrambling to figure out why Fnatic received such a one-sided defeat at the hands of NA’s top team.

Some NA fans point to the fact that “EU is trash” and “should go back to having affordable health care.” Meanwhile, EU supporters counter that not being able to play on their servers for months at a time created a natural disadvantage for European professionals.

Many argue that a deciding factor in the games was when a bald eagle, heeding the cries for help of its NA brethren, swooped down and clawed out sOAZ’s eyes during the laning phase of Game 1.

Perhaps moremodel having the best match score may be selected as the recognition result. Alternatively, the acoustic match score may be combined with other match scores, such as additional acoustic match scores and language model match scores. The word or words associated with the acoustic model or models having the best combined match score may be selected as the recognition result.
For command and control applications, the speech recognition apparatus preferably recognizes an uttered command, and the computer system then immediately executes the command to perform a function associated with the recognized command. For this purpose, the command associated with the acoustic model having the best match score may be selected as the recognition result.
A serious problem with such systems, however, is that inadvertent sounds such as coughs, sighs, or


known as bacosides, are among the few substances that can easily cross the blood-brain barrier to bind to receptor sites in the brain and promote neuron communication. Bacosides also act as powerful antioxidants, supporting and shielding the brain from damaging toxins and free radicals.[14]

Research shows that bacopa has the remarkable ability to nourish the brain and soothe the nervous system, helping to relieve feelings of stress and anxiety.[5]

Exciting gold-standard clinical research on a new patented bacopa extract provides more proof that Dr. Ericson was absolutely right about BDNF’s memory boosting impact, and that bacopa extract is the best way to take advantage of these benefits.

In a double-blind, placebo-controlled study, researchers studied the memory-enhancing effects of this bacopa extract in a group of healthy men and women over 55a medical condition, consult your physician before using this product.

This website is partially supported by third party advertisers. Please note that any product advertised on this site is not specifically endorsed, recommended, validated or otherwise supported by Live in the Now.

Republishing of Live in the Now content without written authorization is strictly prohibited.


the reactivity of a set of tetrazines bearing conceivable boron-coordinating hydroxyl substituents. We hypothesized that the hydroxyl moiety would favor coordination to the VBA and increase the rate constants of the tetrazine-VBA ligation. Furthermore, we anticipate that orthogonality of these tetrazines toward VBAs could be established as more electron-rich tetrazines react less favorably in the general iEDDA reaction with unsubstituted (strained) alkenes.

Results and Discussion {#sec2}
======================

DFT Calculations of the Tetrazine Ligation with VBAs {#sec2.1}
----------------------------------------------------

To provide more insight into the reactivity of the VBA and the boronate anion in the iEDDA reaction with tetrazines, we have explored suitable model reactions using DFT calculations as implemented in the Amsterdam Density Functional (ADF) 2013 software.^[@ref22]^ For all calculations, the generalized gradient approximation (GGA) was used at the OLYP level.^[@ref23]−[@ref25]^ As a basisa multiple independent variable regression analysis provides an efficient method of determining the major and minor conformers. The examples presented are 2-methyl-2-azabicyclo[2.2.1]heptane and 1,6-diazabicyclo[4.3.1]decane, which each have two expected contributing structures, and 2-(diethylamino)propane and 1,8-diazabicyclo[6.3.1]dodecane, where ten and seven low-energy conformers, respectively, are predicted by MM3 calculations.


                        "againstEle2018",
                               ])
tauIdEmbedder.runTauID()

# Output definition
process.out = cms.OutputModule("PoolOutputModule",
     fileName = cms.untracked.string('patTuple_newTauIDs.root'),
     compressionAlgorithm = cms.untracked.string('LZMA'),
     compressionLevel = cms.untracked.int32(4),
     outputCommands = cms.untracked.vstring('drop *')
)
if not minimalOutput:
     print("Store full MiniAOD EventContent")
     from Configuration.EventContent.EventContent_cff import MINIAODSIMEventContent
     from PhysicsTools.PatAlgos.slimming.MicroEventContent_cff import MiniAODOverrideBranchesSplitLevel
     process.out.outputCommands = MINIAODSIMEventContent.outputCommands
     process.out.overrideBranchesSplitLevel =lying next to an area where the inspector was
trying to obtain a paint sample was a “container of blank DVD’s, the very top one obviously
noticeable because of all the other x-rated stuff.” He said the “DVD” had a handwritten
inscription, “‘A Lot of Hanna, Cheerleading, 2011, YMCA,’” or “something like that.”

              Mr. Wilson testified that, after the inspection was finished, he called the chief
of police, who came to the property. Mr. Wilson and/or the chief of police found
“handwritten blank DVD’s” in “nooks and crannies” that Mr. Wilson had not seen earlier.
The chief found money in an unlocked box near the kitchen. Mr. Wilson testified that he saw
20 to 30 video cameras “lying around the house.”


warrant?
                             2. Whether the Sweetwater Police Department’s
               search and recovery of the evidence from the Defendant’s
               residence was lawful in the absence of a search warrant?
                             3. Whether affidavit [sic] of the Sweetwater
           937 S.W.2d 834, 836-37
(Tenn. 1996).

               A basic requirement for a certified question appeal is that the question actually
be dispositive of the case. “Despite that [a] defendant complied with Rule 37(b)(2)(i) . . . and
thereby effectively reserved an appellate issue that the court and the parties below deemed
to be dispositive of the case, we must nevertheless determine that the issue is, indeed,
dispositive.” State v. Gregory W. Gurley, No. W2001-02253-CCA-R3-CD, slip op. at 4
(Tenn. Crim. App., Jackson, Aug. 6, 2002); see also State v. James O. Gambrell, Sr., No.
01C01-9603-CR-00123, slip op. at 4-5 (Tenn. Crim. App., Nashville, May 7, 1997)
(“Satisfaction of the technical requirements does not ensure review by an appellate court.
Appellate review of a properly


but that was not developed
into fruition upon the record in this case. Thus, we hold that the certified questions are

                                              -8-
dispositive of the rape of a child and aggravated sexual battery convictions in case number
12064.

               Therefore, at this juncture, we review the claims of inadmissible evidence with
respect to the convictions of sexual exploitation of a minor, rape of a child, and aggravated
sexual battery, all charged in docket number 12064.can be nothing unlawful in the Government’s appropriation of such
abandoned property.”); Fulani, 368 F.3d at 354.

              In conclusion, the appeals of the following convictions are dismissed: sexual
exploitation of a minor (case number 12092) and child neglect (12091). We affirm the trial
court’s order of suppression, and hence the convictions, for the following counts in case

                                              -12-
number 12064: sexual exploitation of a minor, two counts of child rape, and two counts of
aggravated


Jacket ($165). It’s a more durable and burly version of the popular jacket. Also new are the Ferrosi Windshirt and Crag Pants, ideal for climbers as lightweight, abrasion resistant pieces. The Realm ($279) is a new lightweight, fully waterproof jacket boasting excellent air permeability at 10.9 ounces using their AscentShell fabric.

Patagonia

They’ve revised their M10 jacket, a 3-layer 8.8 oz shell with no seams in the back for comfort while climbing with a pack on. Fans of the Alpine Houdini will likely be excited about the new pants to go with the jacket. A great emergency weather piece for those making light missions into the mountains in the summer, it weighs just under 6 ounces and will retail for $129.

Petzl

Anyone who has several pairs of crampons will appreciate theirboulderers.

On the mountaineering front, they have redesigned their Phantom series to decrease weight and increase warmth. The new Phantom Tech ($749) is 15% lighter than the Phantom Guide, but just as warm.

Salewa

They are adding running shoes to their line, which use Michelin rubber on the soles. Yes, the tire company, which make sense when you think about it. They also have the new Firetail 3 ($139), which promises to fit wide feet better than any of their other models.

Sportiva

The Otaki ($200) is built on the Katana Lace platform, with two velcro straps and the new s-heel, which is a rubber piece that connects the heel to the rand system, pulling more tension into the heel. The Skwama ($150) replaces the Python as a single strap slipper, also with


of the signal are given by expectation values of even powers of $\hat L_z\cos\phi-\hat L_x\sin\phi$ in the state $\hat\rho_b$. Because $\hat L_z$ and $\hat L_x$ preserve the total photon number, only the diagonal terms of the density operator contribute to the relevant moments, which are moments of $N$ with respect to $p_N=\rho_{NN}$. In addition, we have $\hat L_z\hat\rho_b=0=\hat\rho_b\hat L_z$, which implies that $\hat\rho_b$ is invariant under rotations about the $z$ axis; in particular, a rotation by $\pi$, which takes $\hat L_x$ to $-\hat L_x$ shows that moments that have an odd power of $\hat L_x$ vanish.

Using these facts to calculate the expectation value and variance of $\hat{\mathcal{S}}$ gives $$\begin{aligned}
\langle\hat{\mathcal{S}}\rangle&=\langle  \hat L_x^2\rangle\sin^2\!\!\phi\,,\\
V(\hat{\mathcal{S}})
&=\langle  \hat L_x\hat L_z^2\hat L_x\rangle\sin^2\!\!\phi\cos^2\!\!\phi+V(\hat L_x^2)\sin^4\!\!\phi\,,\end{aligned}$$ which leads to a measured-phase variance $$(\Delta\phi)^2=\frac14\left(
\frac{\langle  \hat L_x\hat(1-\mathcal{Q}) N_a$, and $$\begin{aligned}
\tilde{\mathcal{A}}(\mathcal{Q}, \hat{N}_t)
&\equiv \mathcal{Q} \mathcal{A}(\mathcal{Q}, \hat{N}_t) \notag \\
&= 8 \mathcal{F}_a \big( 10 - 3 \mathcal{Q}(4-\mathcal{Q})
-\mathcal{F}_a \big) - 24 \big( 3 - \mathcal{Q}(3-\mathcal{Q}) \big)N_a \notag \\
&\quad+ 3 \mathcal{Q}^3 \big( \mathcal{Q} \langle   \hat{N}_t^4 \rangle + 4 (2-\mathcal{Q}) \langle   \hat{N}_t^3 \rangle \big)\,.\end{aligned}$$ Importantly, when $\mathcal{Q} = 1$, the term in the curly braces on the right-hand side of Eq. (\[eq:Deltaphinorecycle\]) or (\[eq:Deltaphinorecycle2\]) vanishes, and we have $\Delta \phi_{\min} = 1/\sqrt{\mathcal{F}_b}$, so the phase sensitivity saturates the QCRB, as expected.

Since $\mathcal{F}_b = \alpha N_t^2 + \mathcal{O}(N_t^2)$ for some positive constant $\alpha$, we can use the convexity relations $\langle   \hat{N}^4_t \rangle \geq \langle   \hat{N}_t \rangle^4$ and $\langle   \hat{N}_t^3 \rangle \geq \langle   \hat{N}_t \rangle^3$ to determine that, to


leading order in $1/N_a$,

$$\begin{aligned}
(\Delta \phi_{\min})^2
&\gtrsim
\frac{\mathcal{\mathcal{Q}}^4}{\alpha N_a^2}
+ (1-\mathcal{Q})\left( \frac{\sqrt{2(6 \alpha - 1)(8 \alpha^2 - 3) + \mathcal{O}(1/N_a)} + 2(3-2\alpha)}{8 \alpha^2 N_a} + \mathcal{O}\left( 1 / N_a^2 \right) \right).\end{aligned}$$

Therefore, for any deviations from perfect QST on the order of $(1-\mathcal{Q})\agt1/N_a$, the Heisenberg scaling is lost, and we return to the standard QNL scaling $\Delta \phi_{\min} \sim \sqrt{(1-\mathcal{Q}) / N_a}$. Since the initial number of donor particles is typically and desired to be large, in practice Heisenberg scaling is lost for very small departures from perfect [QST]{}.

We demonstrate this point more concretely in Fig. 2 of the main text, where we plot the phase sensitivity for the specific cases where the donor modes are initially in a twin-Fock state or a two-mode squeezed vacuum state. For\frac{3 \sin^4\!\phi}{4}\right)
\langle   \hat{N}_1^2\rangle_N \langle   \hat{N}_1\rangle_N \notag\\
&+\left(-\frac{1}{2} (\cos\phi-1)^4+ \frac{3}{2} (\cos\phi-1)^2 \sin^2\!\phi\right)
\langle   \hat{N}_1^3\rangle_N\langle   \hat{N}_1\rangle_N \notag\\
&+\left(\frac{3 (\cos\phi-1)^4}{8}-\frac{3}{2} (\cos\phi-1)^2 \sin^2\!\phi+ \frac{3 \sin^4\!\phi}{8}\right) \langle   \hat{N}_1^2\rangle_N\langle   \hat{N}_1^2\rangle_N \Bigg)\,,\end{aligned}$$ Specifying the QST process as a beamsplitter, we again use the identities in the previous section to get $$\begin{aligned}
\langle\hat{\mathcal{S}}\rangle
&= \frac{1}{4} \sin ^2\!\phi\bigg( N_t \mathcal{Q}+\frac{ \langle  \hat{N}_t^2 \rangle\mathcal{Q}^2}{2}\bigg)
-\frac{1}{4}  N_t (\mathcal{Q}-1) \mathcal{Q} (\cos \phi -1)^2\,,\\
\langle\hat{\mathcal{S}}^2\rangle&=
\sin ^4\!\phi  \bigg(\frac{1}{16}  N_t \left(\mathcal{Q}-3 \mathcal{Q}^2\right)+\frac{1}{32}  \langle  \hat{N}_t^2 \rangle \left(3 \mathcal{Q}^2-12 \mathcal{Q}+10\right)
   \mathcal{Q}^2-\frac{3}{32}  \langle  \hat{N}_t^3 \rangle (\mathcal{Q}-2) \mathcal{Q}^3+\frac{3  \langle  \hat{N}_t^4 \rangle \mathcal{Q}^4}{128}\bigg) \notag\\
   &\quad+6 \sin ^2\!\phi  (\cos \phi -1)^2
   \bigg(\frac{1}{16}  N_t \left(2 \mathcal{Q}^2-3 \mathcal{Q}+1\right) \mathcal{Q}+\frac{1}{16}  \langle  \hat{N}_t^2 \rangle (\mathcal{Q}-1)^2 \mathcal{Q}^2-\frac{1}{32}  \langle


it.
There are a few situations where it is actually necessary to point your domain to servers you do not own.. like white-label payment services. In a case like that, you point a subdomain that you own (e.g. cash.thedomainyouown.com) at a server owned by the payment provider, and when their servers see a request coming in with your domain name on it, they know to present the user with the payment page for your company.. and the user doesn't notice that you've delegated that service to another company unless they dig in deeper (e.g. verifying IP ownership). These white-label use cases wouldn't work if you had to prove server or IP ownership to set DNS records.

node dissection, complex structures of vasculature, and combined resection of other organs. Due to these difficulties, only a limited number of surgeons choose to perform laparoscopic gastrectomy. However, some researchers have reported that laparoscopic gastrectomy resulted in better short-term outcomes for treating early-stage Siewert-type II/III AEG \[[@pone.0203125.ref007]\]. Further research is needed to clarify the safety and feasibility of using laparoscopic surgery to treat advanced AEG, as well as the long-term outcomes for both early and advanced AEG. In this study, we aimed to examine the short- and long-term effects of using laparoscopic surgery to treat patients with Siewert-type II/III AEG, compared to the open surgery method using PSM.

Patients and methods {#sec006}
====================

Ethics statement {#sec007}
----------------

The study was approved by ethics committee of Shanxi Cancer Hospital before it began. All participants


statement in response to Schoninger, saying: "USA Rugby categorically denies any and all allegations purported by PRO Rugby Tuesday, Dec. 20, and is saddened to hear of the planned termination of all valid contracts signed by athletes that have fulfilled their playing duties for season one and were scheduled to be paid through the duration of their 12-month contracts."

The first season of the five-team competition finished in July with Denver Stampede winning the title but since then one of those quintet -- the San Francisco Rush -- has folded.rats with neonatal exposure to the NMDA receptor antagonist MK-801 and isolation-reared rats exhibited augmented startle responses, but only isolation rearing impaired baseline PPI. Fear conditioning of the prepulse enhanced PPI in socially reared rats, but MK-801-treated rats lost the prepulse feature specificity. Perceptually spatial separation between the conditioned prepulse and a noise masker further enhanced PPI only in normally reared rats. Clozapine administration during adulthood generally weakened startle, enhanced baseline PPI in neonatally interrupted rats, and restored the fear conditioning-induced PPI enhancement in isolation-reared rats with a loss of the prepulse feature specificity. Clozapine administration also abolished both the perceptual separation-induced PPI enhancement in normally reared rats and the fear conditioning-induced PPI enhancement in MK-801-treated rats. Isolation rearing impairs both baseline PPI and attentional modulations of PPI,


as a reference, FA content was determined on an ultraviolet (UV) spectrophotometer at a wavelength of 256 nm. after dilution. FA encapsulation efficiency (EE-FA) was calculated according to Formula (1). The amount of FA added at the time of preparation is denoted as *W~0~*, whereas FA content in the supernatant is represented by *W~F~*. $${EE} - {FA}\left( \% \right) = \frac{W_{0} - W_{F}}{W_{0}} \times 100\%$$

### 2.4.3. Drug-Loading Studies {#sec2dot4dot3-pharmaceutics-11-00584}

The Cur encapsulation efficiency (EE-Cur) and drug-loading capacity (LC-Cur) of the nanoparticles were determined as follows. The amount of Cur added at the time of preparation is denoted as *W~C~*. The prepared drug-carrying nanoparticle dispersion system was centrifuged at 4500 r/min for 15 min, and the supernatant was collected, whereas the precipitates were freeze-dried, weighed, and recorded as *W~m~*. Curso I'm not to sure where to start.

A:

To retrieve the certificates you would use the underlying .NET classes since the Certificates provider does not expose remote machine connectivity by default.  You may find another possibility with PS remoting as well.  Here is the function:
function Get-Certificates {
    Param(
            $Computer = $env:COMPUTERNAME,
            [System.Security.Cryptography.X509Certificates.StoreLocation]$StoreLocation,
            [System.Security.Cryptography.X509Certificates.StoreName]$StoreName
          )

    $Store = New-Object System.Security.Cryptography.X509Certificates.X509Store("\\$computer\$StoreName",$StoreLocation)
    $Store.Open([System.Security.Cryptography.X509Certificates.OpenFlags]"ReadOnly")
    $Store.Certificates
}

And here is how you would use it to compare two lists:
$Left =


See the official trailer for the upcoming album due out on Jan 29th.

Dream Theater are about to release their latest double concept album ‘The Astonishing’ on Jan 29th. The album is 34 tracks and over 2 hours of Prog heaven. Now you can see the official trailer for the this rock opera.the church, things like chanting, vestments, processions, singing
hymns, using the liturgy, stained glass windows, and other works of sacred art.
Why? Because all of these things point us to Christ when they are taught and
used rightly. Luther was a conservative reformer, correcting what was wrong;
preserving what was right.

Is it
because the Reformation is over and it’s time to party? Well, no. Not exactly. The Church is always and ever being reformed. The
Lutheran churches. This church. It’s not simply a once and done deal where you
can kick back and relax. There’s always error, always drift, always a little
sideways current or wind that blows the Church slightly off course. We too are
ever in need of reformation. It’s not about once confirmed always Lutheran or
whatever other false security blanket we try to wrap


the Holy Spirit. Amen.

Every child
builds. Some build castles out of wooden blocks handed down from an older
sibling. Some construct forts out of blankets, chairs, and miscellaneous living
room artifacts. Some erect mansions and small municipalities out of Lincoln
Logs, Tinker Toys, or any other plaything their grandparents or parents saved
for them to enjoy one day. As fun as those pastimes were, my medium of choice
has always been Lego bricks.[2]

I received my
first Lego bricks from family friends in Michigan when I was two years old. They
gave me three five-gallon buckets full of these plastic treasures. And though I
wouldn’t get my hands on them for a couple more years, when I finally did, my
imagination was awakened by them, captivated by these little bricks with
endless building possibilities. Those three buckets were my child-hood
equivalentfeared, loved,
and trusted God above all things.

We have failed to use God’s
name properly and call upon him in every trouble, pray, praise, and give
thanks.

We have despised God’s word
and preaching.

We have not honored our
father or mother or other authorities God has given us.

We have not helped our
neighbor in support of their physical need.

We have not led a sexually
pure life in all we say and do.

We have been dishonest and
poor stewards of our possessions and income.

We have not spoken well of
our neighbor and explained everything in the best and kindest way.

We have coveted more things
and people than we can even remember.

The diagnosis isn’t good.
In fact it’s terminal. But Jesus does not delight in torture or punishment.
Jesus, your Good Physician cuts with the Law in order to heal with the Gospel.
He


doctrines of law of
the case, res judicata, and collateral estoppel. The court generally disfavors the
citation of orders and judgments; nevertheless, an order and judgment may be
cited under the terms and conditions of 10th Cir. R. 36.3.
conviction because the state trial court failed to respond to his motions seeking

appointed counsel; (2) that he was denied the right to effective assistance of

counsel during trial and sentencing; and (3) that he was denied the right to

effective assistance of counsel on appeal.

      On October 18, 1994, Routt was convicted in Tulsa County District Court

upon a plea of nolo contendere to the charge of possession of a controlled

substance after a former conviction. Ten days later, on October 28, 1994, Routt’s

attorney timely filed a motion to withdraw the plea.o.
-4
Solve -24*z - 9 = 3*n - 21*z, -3*n + 2*z = 19 for n.
-5
Solve -u = -4*u - 15, -2*n - 2*u - 16 = 0 for n.
-3
Solve 0 = -34*u + 32*u - y + 4, 3*u + 3*y = 0 for u.
4
Solve 0 = -5*y + 2*m + 23, -3*y - 2*m + 13 = -4 for y.
5
Solve 3*p + 4*y + 11 = 27, -p + 4*y = 16 for p.
0
Solve -2*f - 8 = 4*p - 2, 4*p - f = -3 for p.
-1
Solve w = 2*w - 5*k + 18, 2*w = -5*k + 9 for w.
-3
Solve -4*p - 14 = -3*v, 12 = 5*v - 76*p + 75*p for v.
2
Solve -5*l = -3*t + 10, -t + 5*l + 10 =


-f = t - 0*t + 6 for t.
-1
Solve -d + 5 = -0*d - 2*a, 3*a + 5 = 2*d for d.
-5
Solve 0 = -5*d + 2*l - 43, -26*l + 42 = -5*d - 23*l for d.
-9
Solve 0 = 3*h - 5*w - 25 + 4, 4*w = -h - 10 for h.
2
Solve -3*i + 0*i - 11 = -2*h, 5*i - 5*h + 20 = 0 for i.
-3
Solve -3*l + 15 = -5*b, -59*l - 10 = -61*l - 3*b for l.
5
Solve -5*d - 8 + 30 = 3*x, 0 = -d + 2 for x.
4
Solve 4*p - 4*h - 12 = 0, -6*p + 2*h = -3*p - 7 for p.
1
Solve 3*z + 4*a = 8, 14*z - 18*z - 31 = -3*a for*  on a global basis via a system property wrapper in
 *  [[scala.sys.SystemProperties]].
 *
 *  @author   Paul Phillips
 *  @since    2.8
 */
trait NoStackTrace extends java.lang.Throwable {
  override def fillInStackTrace(): System.Exception =
    if (NoStackTrace.noSuppression)  java.lang.Throwable.instancehelper_fillInStackTrace(this)
    else this
}

object NoStackTrace {
  final val noSuppression = sys.SystemProperties.noTraceSupression.value
}


start in this weekend's clash due to lack of match fitness.

While plenty of focus will be on the players, this is the first El Clasico for Barca boss Gerardo Martino and Madrid coach Carlo Ancelotti, who has led his side to third in the league table after nine fixtures.

Barcelona remain La Liga leaders with an unbeaten record and 28 goals to their name so far, while their arch-rivals have lost once in their campaign so far.

Madrid secured last season's El Clasico 2-1 on home turf, as well as clinching a 3-1 victory at Camp Nou.broken down, streets and sidewalks are a mess of debris and failure, and the goddamn phone won’t stop ringing, sure. But there’s a feeling of surrealism that turns this into a weird reality that isn’t quite alternate enough, a cautionary tale told a minute too late.

At one point, The Well-Dressed Bear walks out of his apartment, still on the phone, the coil cable following behind him, stretched taut and never ending. At another point, he walks through a wall. In terms of perspective, it lets us know that the Well-Dressed Bear is in danger of not fighting the good fight or even being a part of it.

*Ed.’s Note: click image to view larger size.

What other people we see in this world, assuming the Well-Dressed Bear counts as “people,”


Don’t tell me to stop freaking out. How about you stop freaking out? I’m not even freaking out. You think this is freaking out? You should see me when I’m really freaking out. Just, you chill out, all right? How about I won’t tell you to stop flailing your arms in the air if you don’t tell me to get down from this chair? Because I’m not getting down, not until we see where it went, it might still be in here.

There it is, I just saw it, I think it went underneath your jacket. Why didn’t you use the coat hangers? I’m just saying, if that thing gets in a pocket, if it’s pregnant, you’re going to take it home, it’s going to get in the walls,them.

This would be useful for differential input stages or as part of a current mirror, so being matched is absolutely what I'd want. But the other selling points had me scratching my head. One point said the device features “…high DC current gain (>108 ). A sample calculation of the DC current gain at a drain output current of 30mA and input current of 300pA at 25°C is 30mA/300pA = 100,000,000, which translates into a dynamic operating current range of about eight orders of magnitude.”

High current gain? This is an N-channel FET, not a BJT. It's a transconductance device — voltage input, current output. But wait — the gate threshold voltage “features Zero-Threshold voltage.” Hmm… I suppose that would make it a good part to use for very


sleeping well enough. Watch sleep expert Professor Allison Harvey’s talk and read her evidence-based tips for sleeping better.

Therapy can be a great resource when you need a little extra help. Counseling & Psychological Services has a number of satellite offices for graduate students so you don’t have to run into the undergraduates you may teach, and the first five sessions are free. Learn more about counseling resources for graduate students.

More resources are available, and in some cases it is students themselves who have stepped in to fill the gap. Beyond Academia, Thriving in Science, and the overwhelmingly-approved Wellness Fee Referendum are all student-led efforts. Know of a helpful resource for graduate students? Let us know.as a duo until they invited Hippensteel to play alongside them and discovered the sound they’d always wanted.

Waxflight’s main man, Craig Ceravolo, is also its namesake. He created the name by employing what he calls the “Bon Jovi approach”: Cera means wax and volo means flight. And thus Waxflight was born. Alongside Ceravolo is Jonathan Hyatt, who plays bass; Joey Rudisell, who plays drums; and Lester Nuby, who plays guitar. “I think it is pretty great to have people you really like help you make music,” Ceravolo says. “There is nothing better. It sounds great because they are great.”

Ceravolo has been writing songs and playing music since he was 16 and has always loved it. He says major musical influences include The Cure and My Bloody Valentine (particularly


finding it, you might say, instead of getting lost.

“I make a lot of different types of music and for different reasons at that. I find myself leaning toward shoegaze-esque sounds, while also lifting from bossa-nova tendencies, and I’m also very active as an electronic, sample-based dance music artist as well (under different monikers),’ Price says. “However, I’m currently trying to focus on straight-forward rock-and-roll. Others might comment that my music still exists in a sporadic fashion, but for me, I have really simplified the process. In a sense, I’m going for a ‘less is more’ approach.”

His first album under the stripped-down Drew Price is Hustle Strange, which was released in May of this year. “It’s multi-dimensional at times, but for me, it is very stripped down. Everything canStates from CHD in 2007, approximately one in six of all deaths.[@b2-dddt-5-325] Thirty-five years ago, the number of coronary deaths was significantly higher, and the prognosis was limited by the relative dearth of technical, invasive, and pharmacological options.[@b3-dddt-5-325] Currently, there are about 6.2 million hospitalizations for cardiovascular disease each year in the USA, 730,000 hospitalizations for stroke, and 7.2 million cardiac and vascular procedures are performed.[@b4-dddt-5-325] A similar situation now exists world-wide.[@b5-dddt-5-325],[@b6-dddt-5-325]

CVD now consumes 17% of the national health budget in America, where health expenditures, matching the body mass indices (BMIs), are the highest in the world. The cost of CVD in the USA has recently grown at an average annual rate of 6%, and accounts for about 15% of the rise in total medical expenditures. During the


generating another 100,000 prevalent cases of CHD. There is increasing evidence that obesity is offsetting improvements in CHD mortality,[@b8-dddt-5-325],[@b9-dddt-5-325] and a recent comprehensive review by the National Research Council found that the high prevalence of risk factors, particularly obesity, was a major factor accounting for lagging improvement in longevity in America and developed countries.[@b10-dddt-5-325]

Despite remarkable advances considered science fiction just a short time ago, treatment success, as cardiologists well know, remains a constant uphill struggle. The sobering figures above have prompted many epidemiologists and preventive cardiologists to suggest that changes in thinking and approach in primary prevention have been needed for some time. In contrast with the dire predictions outlined above, another pathway is possible. A rich data base,[@b11-dddt-5-325] including the INTERHEART study[@b12-dddt-5-325] and recent models,[@b13-dddt-5-325] suggest aused by Strasser,[@b22-dddt-5-325] refers to individual behavioral lifestyle characteristics that achieve a level of health that does not permit risk factors to appear. The American Heart Association (AHA) incorporated the powerful principle of primordial prevention in defining "ideal cardiovascular health" as a goal in reducing cardiac and stroke mortality 20% by year 2020.[@b2-dddt-5-325] Ideal cardiovascular health consists of the absence of cardiovascular disease, a healthy lifestyle (sufficient exercise, a superior diet score, absence of smoking, and BMI \< 25 kg/m^2^), and ideal health factors (untreated normal values of blood pressure, cholesterol, and fasting glucose). These parameters, termed Life's Simple 7^™^, are presented in an AHA educational site, [mylifecheck.org](mylifecheck.org), which promotes primordial prevention ([Table 2](#t2-dddt-5-325){ref-type="table"}). Presentation of material is layered, clear, in language that is easily understood, and user-friendly.


White,[@b35-dddt-5-325] are needed to refine future approaches.

The accompanying editorial[@b36-dddt-5-325] observed that there were no recent large-scale randomized controlled trials on the issue, and reviewed the pitfalls and perils involved in making educational and behavioral modification programs effective. The design, recruitment, administration (especially adherence verification), and successful completion of such a study presents enormous challenges. Funding for such a project is highly unlikely. In the absence of such randomized trials, the editorialist stressed reducing dietary salt intake, legislating for smoke-free public spaces, and exercise parks to facilitate primordial prevention. Unfortunately, these policies too have encountered obstacles. Environmental restructuring to improve health has been challenged legally, and has been considered intrusive in some venues.

Shortly thereafter, the Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group published three reports28% lower than nonvariants.[@b247-dddt-5-325],[@b248-dddt-5-325] About 3% of the population may have these variations. Such changes correspond to an 88% fall in risk for CHD events, nearly three times the reduction of a 5-year course of statins that reduces LDL-C comparably. On the other hand, gain-of-function mutations in *PCSK9* results in diminished net expression of LDL receptors, producing a clinical picture resembling familial hypercholesterolemia.[@b249-dddt-5-325],[@b250-dddt-5-325] This experiment of nature suggests that favorable levels of LDL-C begun early, and maintained throughout life, are needed for optimum reduction in CVD events. Using the data from *PCSK9* studies, Steinberg[@b251-dddt-5-325] calculated that beginning statin therapy much earlier might double the yield and prevent 240,000 coronary events annually, based upon 2009 CHD mortality data.[@b1-dddt-5-325] By any account, benefits associated with the use of statins and


CVD endpoints (RR: 0.70, 95% CI: 0.61 to 0.79), with variation that was attributed to different populations, statins employed, and reporting ([Table 6](#t6-dddt-5-325){ref-type="table"}). The investigators concluded that no significant harm or change in patient quality of life was caused by statins, and they reported sizeable improvement in all-cause mortality, CHD, and stroke events, as well as number of revascularizations. According to their review, there was selective reporting of outcomes, failure to report adverse events, and inclusion of participants with diagnosed CVD. Despite the evident positive benefit/adverse event ratio, they cautioned against use of statins in primary prevention patients thus: "below a 1% annual all-cause mortality risk or an annual CVD event rate of below 2% observed in the control groups in the trials considered here -- \[statin therapy\]longer period of time to demonstrate during the earlier stages of the disease, ie, during primary rather than secondary prevention. The chief benefit of statins in primary prevention is reflected in lower rates of nonfatal MI. Because mortality is low in such patients, the sensible interpretation is that the therapy was not begun sufficiently early, was not potent enough, or not continued long enough for mortality benefits to become significant. Similarly, one would not ordinarily expect, for instance, a striking reduction in mortality after 3.7 years when treating hypertension or smoking for primary prevention. The implication of the Ray and Taylor studies is that, for a mortality reduction, one should consider denying statins to patients until risk is high (≥20% 10-year FRS score), or the initial coronary event


Long et al[@b313-dddt-5-325] provide a recent authoritative discussion of details in individual trials.

Pletcher and Coxson[@b314-dddt-5-325] discussed the possibility that TC and non-LDL-C were stronger risk factors in the young than the old, with relative risks of 0.44/1-mmol/L fall in TC at ages 40--49 vs 0.72 at ages 60--69,[@b315-dddt-5-325] a relationship which they believed was also suggested in statin trials.[@b233-dddt-5-325] Pletcher et al[@b316-dddt-5-325] performed an analysis of age interaction of LDL-C and cardiovascular responses to statin therapy, and found that age may weaken statin effectiveness. Hayward,[@b317-dddt-5-325] however, disagreed, citing the absence of age-dependent variation in responses to statins in primary prevention in a survey by NICE.[@b283-dddt-5-325]

Glynn and collaborators[@b318-dddt-5-325] analyzed a subgroup of the JUPITER study of 5,695 persons over 70 years of age in the largest primary prevention statincommonly coexist, and current practice guidelines recommend that all risk factors should be addressed for the best outcomes. Hence, a fuller definition of residual risk might be the vascular risk that persists after evidence-based targets are attained for dyslipidemia, hypertension, hyperglycemia, and inflammation.

Lipid-mediated residual risk during statin therapy
--------------------------------------------------

The average adult untreated LDL-C level in the USA is ≈130 mg/dL (3.4 mmol/L). Half of the individuals with "normal" levels ≈100 mg/dL (2.6 mmol/L) will have atherosclerosis by age 50.[@b320-dddt-5-325] In the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE-IT), aggressive lowering of lipids used only prevented ≈20% of cardiac events.[@b321-dddt-5-325] There is ≈30% relative risk reduction with aggressive statin therapy using current guidelines, resulting in about 0.5% lowering of major adverse cardiovascular events (MACE) per mg% reduction in LDL-C,


rosuvastatin in the JUPITER trial was associated with a residual risk of 56%, certainly an impressive improvement.

Using intravascular ultrasound, Bayturan et al found that in about 20% of patients treated intensively down to a mean LDL-C of 58.4 mg/dL (1.5 mmol/L), plaque volume still increased.[@b278-dddt-5-325]

A portion of residual risk arises from atherogenic particles other than LDL-C, especially components of non-high-density lipoproteins (non-HDL). These include intermediate density lipoprotein, very low-density lipoprotein (VLDL), chylomicron and VLDL remnants, and lipoprotein (a). High triglyceride levels, low amounts of HDL-C, and defective HDL also contribute to risk. In the PROVE IT-TIMI 22 trial,[@b323-dddt-5-325] lower on-treatment CV risk was associated with TG \<150 mg/dL. Cardiovascular event rates are higher when HDL-C is low in statin-treated patients,[@b233-dddt-5-325] while the additive risk of low HDL-C valuesmen and 0.69 in women. The Emerging Risk Factors Collaboration,[@b357-dddt-5-325] a meta-analysis with over 300,000 subjects without CHD at baseline, found that rates of CHD per 1000 person-years in the lowest and highest tertiles of baseline lipid distributions, respectively, were 2.6 and 6.2 with triglyceride, 6.4 and 2.4 with HDL-C, and 2.3 and 6.7 with non--HDL-C. On the other hand, in a meta-regression analysis that included 108 randomized trials of lipid reduction upon outcomes[@b358-dddt-5-325] with about an equal number of participants at risk of cardiovascular events, simply raising the amount of HDL-C by 1.7 mg/dL (3.6%) had no effect upon CHD morbidity, CHD mortality, or total mortality after adjusting for the LDL-C levels.

In the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS), the ratio apolipoprotein B (apoB)/apolipoproteinA-I (apoA-I), discussed


of heterogenous particles synthesized in the liver, jejunum, on the surfaces of macrophages, and in serum. They vary in size, density (between 1.063--1.21 g/mL), composition, surface charge, and function. HDL shape ranges from discoid to spherical, depending upon its lipid composition. The biology of HDL is more complex than that of LDL, and capable of slowing atherosclerosis through several mechanisms. The number of regulators -- genetic polymorphisms affecting synthesis of apoproteins, receptors, enzymes that remodel lipoproteins, and inflammatory markers that determine HDL-C levels, maturation, and function -- are staggering, but multiple steps and regulators simultaneously provide additional therapeutic opportunities.[@b364-dddt-5-325] Over 75 different proteins are found within HDL populations that are concerned with lipid metabolism, complement activation, acute phase response; and protease inhibition.[@b365-dddt-5-325] Within the total HDL-C weight, thesubfractions function differently, each with a specific biological function[@b366-dddt-5-325] which is partly dependent upon the triglyceride level. The complex proteasome and lipidosome of HDL particles, in constant flux, may alter individual HDL particle function as its composition changes. The most important protein component is apolipoprotein A-I (apoA-I), accounting for approximately 70% of HDL protein mass, with apoA-II comprising 15% to 20%. Hence, apoA-I is sometimes considered a surrogate for HDL-C. Physically, apo-AI occupies about 85% of the surface of HDL, and it is believed that HDL size is modulated by a twisting motion of the apo-AI molecule. Cross-linking chemistry and mass spectrometry data suggest that apo-AI adopts a symmetrical cage-like structure to hold the lipid cargo. HDL interacts functionally with scavenger receptor class B type I (SR-BI), a


inflammation related to lifestyle, such as visceral obesity,[@b475-dddt-5-325],[@b476-dddt-5-325] and the metabolic syndrome,[@b477-dddt-5-325],[@b478-dddt-5-325] lack of physical activity,[@b479-dddt-5-325] vegetable and fruit consumption,[@b480-dddt-5-325] omega-3 fatty acid ingestion,[@b481-dddt-5-325] and alcohol intake,[@b482-dddt-5-325],[@b483-dddt-5-325] all of which may not be fully captured by other risk markers, such as LDL. In fact, despite great attention to the genetic variations influencing CRP levels, lifestyle is actually the more significant determinant.[@b484-dddt-5-325] Further, CRP levels are associated with all 7 health behaviors and factors that were cited by the AHA as components of ideal cardiovascular health ([Table 2](#t2-dddt-5-325){ref-type="table"}).[@b2-dddt-5-325]

The associations among visceral adiposity, diabetes, metabolic syndrome and inflammatory markers,[@b341-dddt-5-325],[@b485-dddt-5-325],[@b483-dddt-5-325] as well as the relationship between the first three entities with elevated CRP,[@b484-dddt-5-325] are well-known. The link between the metabolic syndrome and atherosclerosis involves elements other than insulin resistance, and CRPin those with hypertension, microvascular and other complications, and after treatment with hypoglycemic, antihypertensive, lipid-lowering and anti-platelet agents.[@b546-dddt-5-325] As mentioned above, CIMT may be more appropriate as a surrogate in some populations and less adequate in others.[@b547-dddt-5-325] Since the intima may thicken, and the media may become hypertrophic with age, not all elevations in CIMT in the elderly are due to atheroma.

Despite widespread use of CIMT serially to assess effects of therapeutic agents, a recent meta-analysis suggests limited usefulness for this purpose. Costanzo et al[@b548-dddt-5-325] undertook a weighted random-effects meta-regression analysis to test mean and maximum CIMT changes and hard outcomes. They included 41 trials totaling 18,307 participants. Despite significant reductions in CHD and CVD events, as well as in all-cause mortality induced by various interventions, they found


operating characteristic curve of 0.81 and 0.78. While a popular subject for debate has been the relative advantages of CAC and CIMT for risk stratification in primary prevention,[@b568-dddt-5-325] these techniques, as well as CRP measurement, are complementary clinical tools, rather than competitors.

For detection of plaque regression, CAC may not be reliable. Some reservations have also been voiced about the clinical usefulness and cumulative radiation exposure in heart patients.[@b199-dddt-5-325],[@b224-dddt-5-325],[@b568-dddt-5-325]--[@b579-dddt-5-325],[@b633-dddt-5-325] While the radiation exposure per procedure is now lower with new technology, exposure is uneven. Cumulative radiation exposure in adults, even in children, is rising, since imaging for all purposes is becoming common.[@b580-dddt-5-325]--[@b582-dddt-5-325] In view of the long delay between exposure to ionizing radiation and development of cancer, as well as its certainty, researchers have suggested that enthusiasm for cardiacthat the absence of coronary calcification (CTCA) had a positive predictive value of 81%, and a lower negative predictive value of CAC of 68%, and therefore a zero CAC score does not reliably rule out significant CHD in patients being referred for coronary arteriography. Of those, about 20% had a high pretest probability of CHD, 75% had an intermediate, and 5% had a low probability of CHD. In an accompanying editorial, Redberg[@b588-dddt-5-325] commented the practice should be discouraged, largely due to the failure to predict 19% of patients with CHD as well as a finite radiation risk. While the radiation for CAC is minimal, with a median value of ≈3 mSv, roughly equal to that of a mammogram or 100 chest x-rays, the variation is considerable (2--7 mSv),[@b224-dddt-5-325]


more people being treated and saved 570,000 more quality-adjusted life-years over the 5-year period. The tailored risk-based strategy resulted in just as many people being treated as intensive treat-to-target therapy, saved 520,000 more quality-adjusted life-years, but did not require as many patients to take high potency statins. More CHD events were prevented with the risk-based approach compared with the treat-to-target strategy, with rates of 62 and 15 per 1000 treated patients respectively. The treat-to-target strategy resulted in treatment of more patients with higher LDL-C levels, but with lower CHD risk, whereas the risk-based approach caused treatment of a greater number of patients with elevated CHD risk, but with lower LDL-C levels.

Using the risk-based approach incorporates the log-linear association between lowering LDL-C and CHD risk, which is maintained atwould virtually be eliminated.[@b608-dddt-5-325],[@b609-dddt-5-325]

In a meta-analysis conducted by the Cholesterol Treatment Trialists' Collaboration,[@b233-dddt-5-325] a total of 170,000 high-risk participants in 26 randomized trials who began with an LDL-C of 1.8 mmol/L (70 mg/dL), were treated down to ≈1.3 mmol/L (50 mg/dL). With each 1 mmol/L reduction, the number of occlusive vascular events fell by about 20%, regardless of baseline LDL-C. However, despite the suggestion that stringent reduction of LDL-C could lower risk by about 40%--50%, reducing events across the board by 50% in the general population, especially with simvastatin, has yet to be demonstrated. In a large study of asymptomatic primary care patients with LDL-C \< 130 mg/dL and CRP ≥ 2 mg/L, those who who attained LDL-C \< 50 mg/dL when treated with rosuvastatin 20 mg showed


LDL-C levels of 50 mg/dL -- values observed in rats, cattle, and deer -- were achieved. Such a prediction assumes that nearly 100% of CHD events may be explained by LDL-C elevation above that putative "physiological" value. In addition, present-day hunter-gatherer individuals experience a different life than those in developed civilizations, with a sizeable difference in exercise level, stress and pollutant exposure. Hence, while more intensive reduction in LDL-C will produce significant improvements in reducing cardiovascular events, only a partial, rather than total, amelioration will likely result from this proposal.

Follow treat-to-target lowering of LDL-C, but raise HDL-C
---------------------------------------------------------

Keeping in mind that just ≈30% of cardiovascular events are prevented with statins, and even when maximally tolerated doses are used, only a further 16% can be suppressed, Drexel et al[@b613-dddt-5-325] sought\<100 mg/dL, which may change in ATP IV guidelines. These investigators also agree that the LDL-C value at birth, ≈50 mg/dL, may be physiological, and cardiovascular benefits would be expected until those values are reached.

Give statins to low- and intermediate-risk individuals within a polypill
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The polypill concept was proposed by Wald and Law[@b614-dddt-5-325] to lower LDL-C, blood pressure, serum homocysteine, and inhibit platelets regardless of pretreatment levels in a large segment of the population (over age 55), produce few side effects, with minimal expense. As safety of treatment rises and expense falls, risk stratification is considered less valuable. One-third of people taking this pill from age 55 were expected to benefit, adding an average of 11 years to life, free from a CHD event or stroke.[@b614-dddt-5-325]

In the Indian Polycap


all adults. Similarly, a family history was recommended for all patients. While recognizing the large risk burden in asymptomatic adults, difficulty in identification of patients who ultimately suffer cardiovascular events, the significant number of patients who remain untreated and eventually succumb to CHD deaths, this guideline set forth evidence-based recommendations for the identification and stratification of patients at risk.

Use of the Reynolds Risk Score, particularly in women, deserves consideration.[@b629-dddt-5-325] Lowering the threshold for risk level may bring more care to patients who will benefit. In the 2011 American Heart Association update to the guidelines for prevention of cardiovascular disease in women,[@b629-dddt-5-325] "high risk" among women is now defined as a 10-year CVD risk ≥ 10% rather than ≥20%.

Of all biomarkers, CRP is the best studied circulating biomarker, andinformation may be grouped together.

A working hypothesis of the ET partition applied to QCTC is that the sum of distribution times for each ET sub-box is constant irrespective of the sectioning. However, for very fine grained parallelism, shifting a bisecting plane may induce a relatively large change in the total predicted distribution time in a sub-box. This is due to the fact that the total workload may not be equally divided among the sub-boxes because the distribution times are discrete (a distribution is either [*totally*]{} or not in a sub-box). Also, for very fine grained parallelism, the total work in a sub-box is more sensitive to a change in density that may also increase the load imbalance, an effect which we have experienced in parallelization of the exchange-correlation


The efficiency of the ET partition ranges from 91 – 98 % for all test cases presented in this work at the 128-processor level. The overall QCTC speedup, however, ranges from 63 – 81 % overall efficiency at the 128-processor level with fine grained parallelism. The decrease in efficiency is mainly due to the parallel tree build process. While the current simple implementation of the parallel tree build should eventually be replaced by a more sophisticated version, the current implementation has enabled us to run routine calculations to address a wide range of interesting problems[@CGan04C; @CGan04A].

This work has been carried out under the auspices of the U.S. Department of Energy under Contract No. W-7405-ENG-36 and the ASCI project. Most work was performed on the computing resources at the Advancedinvestigate the effects of AlF~3~and LaF~3~coatings under severe conditions, the pristine and coated samples were cycled at 45°C in the voltage range of 4.25 to 3.0 V (at a current density of 0.4 mA· cm^-2^). The high temperature activates the chemical reactions between the electrolyte and the electrode surfaces, thereby causing deterioration of the electrode. As expected, the discharge capacity of the pristine film showed a rapid fading effect. The discharge capacities of the AlF~3~- and LaF~3~-coated films also deteriorated during cycling. However, they showed greatly enhanced cyclic performances, as observed in Figure [3](#F3){ref-type="fig"}. This improvement may be attributed to the stable fluoride coating layer. The fluoride coating layer has been reported to offer high resistance to acidic electrolyte during cycling \[[@B3]\]. The stable AlF~3~and LaF~3~coating layers successfully


that. What matters more, my theory or existing reality? I faced that problem in early 2013 and concluded that I had, as a matter of intellectual integrity, to defer to reality, even if it meant admitting the wrongness of my position or even that of Mises’s. Shocking, I know!

Wendy: The crypto community parallels the libertarian one, in ways both good and bad. An example of the latter is the deep personal schisms with which it is rift. You are a person who stays away from internecine battles. What advice do you have to others who wish to do the same?

Jeff: I try to stay focused on the big picture and imagine that my audience is not my friend network but rather the general public. I try to servebattle over word processors. Microsoft kept making Word larger and larger, puffed with cruft, and the code monkeys were screaming that this was a disaster in the making. For my own part, I hated Word in those days and completely agreed that the hard-to-use light-weight programs were better.

But guess what? The market disagreed. Moore’s Law kicked it as it always does and eventually Word destroyed the competition. Why? Because it had more features that users like. Eventually the code got clean again and now Word itself has many elegant competitors. This is the normal progression of any software with a consumer focus.

Incredibly, some people with the keys to the kingdom of Bitcoin actually came to imagine that they could develop a digital money without an efficient, consumer-focussed use