methods. We emphasize at this point that our goal is not to accurately estimate the precise numerical value of the scaling exponents that characterize the density of vibrational modes. Our aim is rather to identify trends in the observed exponents upon systematically varying the preparation protocol of the glassy samples.

In Fig. \[fig3\] we show the means and the 2nd-9th deciles of the participation ratio $e$ binned over frequency $\omega$. The participation ratio of a vibrational mode $\hat{\Psi}$, defined as $e\!\equiv\!\big( N\sum_i (\hat{\Psi}_i\!\cdot\!\hat{\Psi}_i)^2 \big)^{-1}$, is a simple measure of the degree of localization of a mode: the more localized a mode is, the smaller its participation ratio is expected to be. In [@modes_prl; @SciPost2016] it has been shown that the participation ratio of low-frequency glassy modes scales as $N^{-1}$, indicatingthe quench makes it possible to form barely-stable glasses that would possess local soft potentials $U(s)$ that have deeper minima at $s\!\ne\!0$ compared to $U(0)$, e.g. asymmetric double well potentials [@soft_potential_model_02]. Creating such unstable structures in slowly quenched glasses is much less likely. According to the discussed framework, one may hypothesize that $\beta\!=\!3$ should be observed in glasses created by an instantaneous quench; we indeed find $\beta$ very close to 3 in samples that were instantaneously quenched from very high temperatures, see Fig. \[fig2\].

In this work we followed the simple approach of [@modes_prl] and investigated the density of vibrational modes in small, three dimensional model glasses, in which Goldstone modes are sufficiently suppressed to expose a population of quasilocalized soft glassy vibrational modes. This approach is, however, still limited in


Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: a randomized controlled study.
Tunneled catheters are widely used for the provision of hemodialysis. Long-term catheter survival is limited by tunneled catheter-related infections (CRI). This study assesses the efficacy of catheter-restricted filling with gentamicin and citrate in preventing CRI in hemodialysis patients. A double-blind randomized study was conducted to compare heparin (5000 U/ml) with gentamicin/citrate (40 mg/ml and 3.13% citrate; ratio 2:1) as catheter-lock solutions. A total of 112 tunneled catheters in 83 patients were enrolled at the time of catheter insertion for commencement or maintenance of hemodialysis. The primary end point was CRI. Catheter malfunction, defined as blood flow rate of <200 ml/min for three consecutive dialyses and/or the use of urokinase, was also assessedIntroduction
============

Durum wheat (*Triticum turgidum* ssp. *durum* Desf., 2*n* = 4*x* = 28, AABB) is the 10th most important crop worldwide owing to its annual production of 37 million tons ([@B33]; [@B56]; [@B69]). It is grown on about 10% of the world's wheat area mostly in West Asia, North, and East Africa, the North American Great Plains, India, Eastern and Mediterranean Europe ([@B10]; [@B27]). With the exception of Europe, North Africa (Algeria, Morocco, Tunisia, and Libya) is the largest import market for durum wheat ([@B5]). Its final uses vary between industrial production of pasta, couscous, and other semolina products and traditional handmade foods such as *frike*, bourghul, and unleavened breads. The vast array of homemade foods derived from durum grains is the result of its long history as part


it groups together material from several countries and breeding programs such as Spain, Morocco, ICARDA and CIMMYT. It originates from the sharing of several germplasm sources among breeders targeting similar Mediterranean growing conditions. Thus, the genetic similarity between this germplasm can be explained as the common origin of allelic sources, together with the imposition of similar selection pressure for specific traits. This cluster has the highest rate of genetic diversity (PIC = 0.14) and portion of captured alleles (58%) than any other cluster of modern germplasm. In addition, the high admixture (**Figure [3](#F3){ref-type="fig"}**) and central position in the DAPC graph (**Figure [2](#F2){ref-type="fig"}**) confirm that this cluster is the founding base that guarantees good exchange of alleles among all other breeding programs.

Germplasm from USA, Australia, and Canada were groupedTheresa’s Story

It's only in the dark skies that we can see the brilliance of the stars...

My Story & How YUM Came To Be…

As you may know, I’m a psychologist and a mom. The truth is, I am now also a Gourmet Raw Food Chef and Nutrition Instructor, as well as a Certified Integrative Energy Healer, and student of several other osteopathic healing modalities (e.g. Craniosacral Therapy, Lymph Drainage, Visceral Manipulation, and Neural Manipulation). However, becoming a chef was a very unexpected development.

While I’ve always been a great cook, historically I never really liked to cook! Especially growing up in a very gender-typed family, I grew up associating “cooking” with “women’s work”. As a strong and opinionated woman, it is not difficult to appreciate my lack of affection for


discovered that at the root of my debilitation was my body’s disapproval of some of the food that I ate—most notably, gluten, dairy, and potatoes. Once this awareness came to the light, my health finally began to turn around. It was a long journey, but an important point along the way was when I decided to shift my perspective about my food restrictions to focus on what I “could” eat, instead of what I had to live without. I thought of it like a painter’s palette to create new art and as a creative challenge.

At first, the process seemed grim, but being the persistent solution-seeker that I am, nothing could stop me on my mission. After years of experimenting, I successfully created insanely yummy and healthy plant-based foodhowever large or small. Thank you for being a part of this vision of hope for a better world.

“Our footprints on the planet, our bodies, and on each other’s hearts really do matter.” ~Dr. Theresa


The limited production Steeda Q750 StreetFighter Edition is the most uncompromising and best performing supercharged road car Steeda Autosports have ever produced.

Steeda’s great Q750 Mustangs are also available in a special limited edition “Midnight Edition”, a trim package to complement the Q750 StreetFighters tremendous get up and go performance.

–

Q750 StreetFighter and Midnight Edition adds a huge dollop of Whipple 2.9L Supercharged power to deploy a full array of Steeda’s legendary handling and drivetrain upgrades. The exclusive Steeda G-Trac Suspension System, with its fully adjustable damping and specially-tuned components, provides an exhilarating driving experience and outstanding vehicle dynamics and take the Mustang’s handling to a completely different level.

And where else can you get the 2.9 Whipple Stage 2 supercharger and all those other goodies and STILL have a warranty?!?the monster that lies beneath.

With 825 horsepower burbling beneath the hood waiting to be turned loose, the Steeda Q750 Midnight Edition delivers a combination of presence, quickness, top speed, precise handling, and overall performance that is second to none.


meaning of the fast for us. While many Catholics, Muslims, and Baha’is feel that the act of sustained self-denial brings them metaphysically closer to God, he and I have had no such experience. We personally reject such sudden discovery of piety; instead, of ourselves we demand consistency. As I recently put it to a Flemish comrade, “I was a screwed-up jerk before the fast and I remain a screwed-up jerk during the fast; the big difference is that now I’m starving.”

But of course that’s not the main difference. It’s perhaps surprising considering our normally mystical inclinations, but Tony and I instead find ourselves understanding the fast in worldly terms of challenge and, most of all, ethics. We see the fast as an act of solidarity for those sufferingpregnancy.

"He just thought I was too young and I hadn't finished school," Bruce said. "And how was I going to support the baby?"

Bruce said she'd had doubts about the abortion from the beginning, describing her emotions after finding out about the pregnancy as excited and nervous at the same time.

"I was really confused, asking everybody else what I should do. Everybody told me, 'You were too young,'" she said. "What I really wanted to hear was, 'We'll help you out.'"

In the end, she walked into the clinic. When a technician performed a sonogram and handed Bruce the picture of her 6-week-old fetus -- even though she had specifically filled out paper work saying she didn't want to see the ultrasound or any pictures -- she began to seriously


Hodari had already placed the dilator into her uterus," Weiss said. "By that time the pregnancy had been terminated. He had to continue the abortion."

Though Hodari did remove the dilator at Bruce's request, Weiss said, her health would have been in jeopardy if he didn't finish.

Weiss pointed to Bruce's own expert witness who Weiss claimed agreed that the doctor should have finished the abortion once the pregnancy was no longer viable.

"From that point on her own expert witness has said Dr. Hodari acted within reason," he said.

But Pabst argued that "we weren't at that point" in the procedure.

"The water wasn't broken," the lawyer said. "She hadn't felt the pain her in belly."

Vicki Saporta, president of the Washington, D.C.-based National Abortion Federation, a professional association of abortion providers, saidis usually currency-specific. In other words, this address belongs to a certain blockchain.

Sometimes it is obvious which blockchain the address is coming from. For example, all Ethereum addresses start with 0x:

In Freewallet, when our users want to send coins, we perform an instant check to make sure the address has the right format. This way, Bitcoins are going to be sent to a Bitcoin address, not an Ethereum address.

Problems begin when two currencies have similar address formats.

For example, Bitcoin Cash appeared due to a hard fork on the Bitcoin blockchain, that is why it initially used the same address format. In January 2018, BCH updated its address format to avoid confusion with established Bitcoin addresses, but the addresses generated before the update are still operational.

So, what exactly happens


Employment statistics

Regions with the largest number of jobs related to 'DY Manager TPM' are Karnataka, Haryana, Maharashtra, Tamil Nadu or Gujarat.
Cities with the largest number of results are Bangalore, Gurgaon, Chennai, Pune or Ahmedabad.rant on my page while i am out on the town watching traffic for my LE classes, i get to write people up for tickets and i don't even have a badge yet. man you would be surprised how bad some people drive. on a totally related subject, there was this whole drunk driving thing at my school and they brought in a drunk driving simulator, it was frekin difficult. i was horrible i didn't even come close to passing i failed while the game was still on the stone cold sober setting. i guess i really suck on simulated driving cuz i am normally an excellent driver. well i guess that's enough of a rant for now now its time to watch some animations i have been


own videos to take part in the project and ended up in the top five of the participating countries Germany, Austria, Switzerland, France and Norway. In the end, each of them won Arnette product support for the upcoming season 2011/2012 along with this road trip through some of the Alps’ hotspots.

The set-up was perfect that Friday night in Saas Fee. Motivation and excitement to start off a ten day road trip couldn’t have been higher. Nobody knew that there were three down days full of weather antics to outlive. We’ve been told that the Saas Fee Glacier hadn’t been closed for so many days in a row in the last two decades. However, weather is what you have to deal with when you want to go snowboarding.

But ArnetteQ:

Count of Files attached to Custom Object Record

I am trying to do (what I think is) a simple trigger that counts the number of files attached to a custom object record(SBQQ__QuoteDocument__c) and puts that number in a field on that object. I am trying to query ContentDocumentLink because after some research that seems like the correct object that holds the Quote Document Id(as LinkedEntityId) and the File Id in the same place. I am doing this so I can run validation rules to make sure a user has uploaded a file to each Quote Document record before Opportunity can be marked Closed Won, that part will be easy. I do not want to go the DLRS route or install any new apps because client is wary of doing


       parentQuoteDocumentIds.add(cdl.LinkedEntityId);

You may want to do some filtering here, probably on cdl.LinkedEntityId.Type, since you're only interested in parents that are SBQQ__QuoteDocument__c. Your current code silently works because of the way your query is structured, but if you start using this collection in other ways down the line, you may not remember that your collection could contain other Ids too and find unexpected behaviors.

        }

        List<SBQQ__QuoteDocument__c> quoteDocList = [SELECT Id FROM SBQQ__QuoteDocument__c WHERE Id IN :parentQuoteDocumentIds];

        for(SBQQ__QuoteDocument__c qd : quoteDocList){

            qd.Number_of_Files_Attached__c = quoteDocList.size();

        }

Here'sWHERE Id IN :parentQuoteDocumentIds];

Then, iterate over the documents and set each one's Number_of_Files_Attached__c field to qd.ContentDocumentLinks.size().
And lastly, don't forget that you have to perform DML to persist these changes:
update quoteDocList;


A new species of moth with a wingspan of a mere 0.4 inches, beady eyes, golden coifh has been named after the soon-to-be 45th US president.

And ironically, Neopalpa donaldtrumpi‘s native habitat lies between the US and Mexico.

Evolutionary biologist Vazrick Nazari said in a research paper published on ZooKeys that the moth was discovered in 1998 in California, but new specimens discovered south of the border had different features than their cousins and so was determined to be a different species within the Neopalpa genus.

One of the main differences between n. donaldtrumpi and n. neonata is the yellowish-white scales on its head, the scientist noted.“Its distinctive wing pattern and its unique DNA bar code immediately flagged it as a new and un-described species,” Nazari, a researcher from Ottawa, Canada,\mathbb{T}^{2}$, $$\mathbb{E}\int_{0}^{T}|Z(t,x)|^{2}dt<+\infty$$ so that the Itô’s integral $\int_{0}^{\cdot }\langle Z(\cdot
,x),dB\rangle $ is a square integrable martingale for every $x$.

3\) It holds that $$Y(t,x)=\xi (x)-\int_{t}^{T}\langle Z(s,x),K(Y(s,\cdot ))(x)\rangle ds-\sqrt{2v}\int_{t}^{T}\langle Z(s,x),dB_{s}\rangle$$ almost surely on $\Omega \times \mathbb{T}^{2}$, for $t\in \lbrack 0,T]$.

Now we are in a position to state our main result.

\[main-th\]Under above assumptions on the terminal value $\xi $, there is a unique solution pair $(Y,Z)$ to BSDE (\[b-12-01\]) such that

1\) $Y$ is bounded on $\Omega \times \lbrack 0,T]\times \mathbb{T}^{2}$, and

2\) For almost all $x\in \mathbb{T}^{2}$, the Itô integral $\int_{0}^{\cdot }\langle Z(\cdot ,x),dB\rangle $ is a BMO martingale, and $$\text{ess}\sup_{[0,T]\times \Omega }\mathbb{E}\left\{ \left.
\int_{t}^{T}||Z_{s}||^{2}ds\right| \mathcal{F}_{t}\right\} <+\infty$$where $||\cdot ||$ denotes the $L^{2}$-norm on $\mathbb{T}^{2}$.

In particular, by applying Theorem \[main-th\] to $\xi =\varphi (B_{T})$ where $\varphi =\nabla \times u_{0}$ is bounded, $C^{2}$ on $\mathbb{T}^{2}$, then


}  \label{l-12-24-6}$$ for $t\in \lbrack 0,T]\times \mathbb{T}^{2}$.

It is clear that $$\begin{aligned}
\partial _{j}Y(t,x) &=&\mathbb{E}\left\{ \left. \partial _{j}\xi (x)\frac{R(T,x)}{R(t,x)}\right| \mathcal{F}_{t}\right\} \\
&&+\mathbb{E}\left\{ \left. \xi (x)\left( -\int_{t}^{T}\langle \partial
_{j}h(s,x),dB_{s}\rangle -\int_{t}^{T}\langle h(s,x),\partial
_{j}h(s,x)\rangle ds\right) \frac{R(T,x)}{R(t,x)}\right| \mathcal{F}_{t}\right\}\end{aligned}$$so we have the following simple fact.

\[lem-dec1\]1) If in addition $\xi $ and $h$ are bounded, then the solution $Y$ is continuous in $(t,x)$.  2) If in addition $\xi $ and $h$ have bounded derivatives in $x$, then so is $Y$.

Proof of Theorem \[main-th\]
============================

This section is devoted to the proof of Theorem \[main-th\]. We will use the following convention in our proof. The elliptic estimates show that if $f\in W^{k,2}(\mathbb{T}^{2})$ then $K(f)\in W^{k+1,2}(\mathbb{T}^{2})$, thus if $k\geq 1$, then, according to the Sobolev imbedding, $K(f)$ has a Hölder continuous version. Therefore, if $f\in W^{1,2}(\mathbb{T}^{2})$ for $k\geq 1$, $K(f)$ is alwaysfor all }(t,x,n)\in \lbrack
0,T]\times \mathbb{T}^{2}\times \mathbb{N}\}=1\text{.\ }  \label{bd-01}$$ Theorem \[th-3\] implies that $\{Y_{n}\}$ is a Cauchy sequence under the norm $||\cdot ||_{\alpha ,\infty }$ for some $\alpha >0$, and therefore has a limit $Y$ which is a solution to (\[b-12-01\]).

[99]{} S. Agmon, A. Douglis, and L. Nirenberg, *Estimates near the boundary for solutions of elliptic partial differential equations satisfying general boundary conditions. [I]{}*, Comm. Pure Appl. Math. **12** (1959), 623–727. [MR ]{}[0125307 (23 \#A2610)]{}

S. Agmon, A. Douglis, and L. Nirenberg, *Estimates near the boundary for solutions of elliptic partial differential equations satisfying general boundary conditions. [II]{}*, Comm. Pure Appl. Math. **17** (1964), 35–92. [MR ]{}[0162050 (28 \#5252)]{}

J.-M. Bismut, *Théorie probabiliste du contrôle des diffusions*, Mem. Amer. Math. Soc. **4** (1976), no. 167, xiii+130. [MR ]{}[0453161 (56 \#11428)]{}

P. Briand and Y. Hu, *Quadratic [BSDE]{}s with


light emission from green to orange or red.
With respect to long wavelength light emission of yellow to red, known light emitting materials or dopant materials include laser dyes capable of red oscillation (EP 0281381), compounds capable of exciplex emission (JP-A 255788/1990), perylene compounds (JP-A 791/1991), coumarin compounds (JP-A 792/1991), dicyanomethylene compounds (JP-A 162481/1991), thioxanthene compounds (JP-A 177486/1991), mixtures of a conjugated polymer and an electron transporting compound (JP-A 73374/1994), squalirium compounds (JP-A 93257/1994), oxadiazole compounds (JP-A 136359/1994), oxynate derivatives (JP-A 145146/1994), and pyrene compounds (JP-A 240246/1994).
Other light emitting materials disclosed heretofore include condensed polycyclic aromatic compounds (JP-A 32966/1993 and 214334/1993). Also dopant materials proposed heretofore include various condensed polycyclic aromatic compounds (JP-A 258859/1993).
These light emitting systems, however, do not provide high luminance or stable light emitting performance. AWyeast 3068 - Weihenstephan

$11.50

Old price:$13.50

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Availability:In stock

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Wyeast 3068 - Weihenstephan - Manufactured December 2018Classic German wheat beer yeast, used by more German brewers than any other strain. Dominated by banana ester production, phenols and clove-like characteristics. Extremely attenuative yeast, which produces a tart, refreshing finish. Yeast remains in suspension readily with proteinacous wheat malt. Sometimes used in conjunction with lager yeast and kraeusened to finish the beer and improve the overall dryness. High CO2 levels, typically at 2.7 - 3.2 volumes is desirable for best presentation. This strain is a true top cropping yeast requiring full fermenter headspace of 33%. Increasing pitch rates will reduce ester production. Alcohol tolerance: approximately 10% ABV

Wyeast 3068 - Weihenstephan - Manufactured December 2018Classic German wheat beer yeast, used by more German brewers than


costumes will tip them off anyway." "We'll just say it's a fashion choice." "We need to see one of the inmates." "Why, certainly, Superman." "Right this way." "Oh, one little thing." "Today's password?" "Applesauce." "Applesauce." "Right." "But Wonder Woman was supposed to say it." "[ALARM WAILS]" "Weasel." "You must be stopped." "A robot!" "I built mine to take over for me when I had to be away." "GREEN LANTERN:" "Looks like the other guy had the same idea in spades." "[GRUNTING]" "BATMAN 2:" "I knew you'd come here." "Just like I know you're going to" "Do that." "BATMAN 2:" "What are you hiding for?" "BATMAN:" "I do my best work in the dark." "BATMAN 2:" "I used to think that, but what did you accomplish from there aside   this.setupVirtualColumns();

        assert.strictEqual(this.getColumns().length, 53, 'column count');
        assert.deepEqual(this.getFixedColumns().map(function(column) {
            return column.dataField || column.command;
        }), ['bandField1', 'bandField2', 'transparent'], 'fixed columns');
        assert.strictEqual(this.getFixedColumns()[2].colspan, 9, 'transparent column colspan');
        assert.strictEqual(this.getVisibleColumns().length, 11, 'visible column count');

        assert.deepEqual(this.getVisibleColumns(0).map(function(column) {
            return column.caption || column.command;
        }), ['Band', 'Field 1', 'Field 2', 'Field 3', 'Field 4', 'Field 5', 'Field 6', 'Field 7', 'Field 8', 'virtual'], 'first header


column location if scroll position at begin', function(assert) {
        this.setupVirtualColumns();

        assert.strictEqual(this.getVisibleColumns().length, 11, 'visible column count');
        assert.strictEqual(this.getVisibleColumns()[10].command, 'virtual', 'virtual column is added to end');
        assert.strictEqual(this.getVisibleColumns()[10].width, 50 * 40, 'virtual column width');
    });

    QUnit.test('virtual column location if scroll position at end', function(assert) {
        this.setupVirtualColumns();
        this.columnsController.setScrollPosition(50 * 50 - 400);

        assert.strictEqual(this.getVisibleColumns().length, 11, 'visible column count');
        assert.strictEqual(this.getVisibleColumns()[0].command, 'virtual', 'virtual column is added to begin');
      'virtual', 'virtual column is added to end');
        assert.strictEqual(this.getVisibleColumns()[12].width, 50 * 19, 'virtual column width');
        assert.strictEqual(this.getVisibleColumns()[13].dataField, 'field2', 'fixed column is added to end');
    });

    QUnit.test('columnsChanged event should be fired during scrolling to right', function(assert) {
        const columnsChangedPositions = [];
        let pos;

        this.setupVirtualColumns({ width: 420 });

        this.columnsController.columnsChanged.add(e => {
            assert.deepEqual(e, {
                optionNames: { all: true, length:


from styles', function(assert) {
        $('#container').css('width', '200');
        this.setupVirtualColumns();

        assert.strictEqual(this.getColumns().length, 50, 'column count');
        assert.strictEqual(this.getVisibleColumns().length, 6, 'visible column count');
    });

    QUnit.test('columnHeaders scroll position during virtual scrolling', function(assert) {
        this.setupVirtualColumns({
            width: 200,
            scrolling: {
                mode: 'virtual'
            },
      Q:

How can I download files from my Android app?

I have an app, which needs to download some files from server and use them.

How can I download them? Techniques and samples are welcome.
Where can I store these files, so that my app might use them in the future?

A:

You can use AsyncTask to do this type of functionality. See this link for reference.


locate them and “stop the
contract sale” of the vehicles, unsuccessfully.

        Vehicles that the City sells at the auction are stored at the City impound yard
until the winning bidders complete their purchase and retrieve their vehicles. Under the
auction’s Terms and Conditions,1 a bidder must submit full payment within five days
of the auction’s close. If the bidder fails to remove the vehicle within 30 calendar days
after submitting payment, the bidder is deemed to have ceded ownership of the vehicle
to the City, and the City can dispose of the vehicle and retain any proceeds.

        Sroga filed suit under 42 U.S.C. § 1983, asserting that the individual defendants
violated the Fourth Amendment by unlawfully seizing his vehicles and thatof Dranesville, and with the help of the Brethren, they’ll be remembered.

A beautiful and respected way to all ways remember . Not at all like the two confederate monuments to add to the growing list of being tore down in spite of majority feelings .Send away to an unidentified location .SHAME on you memphis .spelled with out a capitol on purpose


Q:

Automate the Boring Stuff with Python : Hello World Code 1

I am trying to learn Python with this book "Automate the boring stuff with Python". However , I am stuck with the first code itself.
I have simple copied this code on my Editor File:
print('Hello world!')
print('What is your name?') # ask for their name
myName = input()
print('It is good to meet you, ' + myName)
print('The length of your name is:')
print(len(myName))
print('What is your age?') # ask for their age
myAge = input()
print('You will be ' + str(int(myAge) + 1) + ' in a year.')

In the Shell window I get the first two lines but as soon as I input my name, it gives me an error. I don't know what am I doing wrong.
Python 2.7.8 (default, Jun歡迎光臨gamblel0在痞客邦的小天地

Simple guitar playing tips can be the contrast involving a guitarist who improves commonplace due to simplified practicing or cause who on the odd occasion gets greater because they practice the inappropriate holding or the permission material possession the misguided way. Learning to comedy stringed instrument can be a mine tract so I have compiled a schedule of frugal tips to assist you time acquisition to play guitar.

Guitar musical performance tip 1:

Decide what kinds of material possession you deprivation to be able to stage show. Many grouping ne'er offer this a thought, and so they kind of bollix up through with and acquire the odd nursery rhyme/lick present and there, and after a few eld they can leap any guitar but they aren't correctly the musician they fanciful


you and your spouse have complex and potentially competing interests.

Saturday, October 29, 2011

Have we bounced back from the Great Recession or are we still languishing (and due for another fall backwards)? This is a hot topic in political and economic circles, let alone around kitchen tables. It’s also a question of importance in the world of philanthropy. As the Chronicle of Philanthropy reports, America’s biggest charities are expecting modest growth in 2011, but face challenges in rebounding from the 2008 tumble. One way the Chronicle charts the world of charitable giving is through the Philanthropy 400, tracking the largest 400 charities. Think of it as the Forbes 400 of charities. Out of these 400, the expectation is that charities will see a modest median rise of 4.7% bythe end of 2011. That is good news because this will be a net rise over 2010 growth, when charities were able to gather up an additional median gain of 3.5%. Nevertheless, those charities are still below 2007 levels and much of the gains have been in the form of donated medicine, food, and services rather than monetary funds. The Chronicle counts the 400 as a barometer of the charitable world. As such, it is a reminder of the many needs out there. The article also charts some patterns in charities of interest to the savvy philanthropist. There is a bit of promising news for the charitably inclined, too, as headway has been made on the worldwide malaria problem, with charitable organizations at the forefront of vaccine development.


of six Democrats and six Republicans who must make significant budgetary recommendations by late November. By Christmas-time this year, Congress must act on these recommendations, or find a better solution, or else severe cuts will go into effect across both military and entitlements spending like Medicare and Social Security. For now, seniors can breathe a bit easier. But, clearly, the debt crisis has been postponed rather than resolved.

Saturday, October 15, 2011

I ran across an article last week written primarily for physicians (PhysiciansNews online), and while the advice was sound, the message really is appropriate for anyone who wants to preserve their hard-earned wealth and create a family legacy. Here are the high points: • It’s never too soon to start planning your estate. At a minimum, your estatedue to the nature of their employment.

Friday, October 14, 2011

There is an old saying that can be painfully true, “You are only as happy as your unhappiest child.” One of the most common laments I hear from parents of adult children is that, for whatever reasons, their offspring seem to (repeatedly) need financial assistance … not because of illness of hardship, but simply through poor decision-making. It’s hard to talk-turkey with your adult children, and they seldom listen anyway. But, maybe they will listen to advice from a third-party, especially if that advice is delivered in a manner with which they are most comfortable – fresh, fun and online. American Express has launched Currency (www.getcurrency.com) to provide just that type of advice. They offer online “courses,” and even


a new iPhone app, Social Currency for social networking. A recent hot topic: Currency 101: What is “Spending”? Some of other course topics include Buying Your First Home, Get a Handle on Your Taxes, and Managing Student Loans.

Thursday, October 13, 2011

Coping with the physical, emotional or developmental disabilities of a special needs child is part of the daily life of many parents. Then there is the added financial burden of providing care and security for all family members, both today and in the future. Parents are encouraged to call upon the trained expertise of financial and legal advisors. Last week, The Times Herald ran an excellent brief article highlighting some of the important aspects of Special Needs Planning, to include: • Retirement and Estate Planning for the parents.Cabbage Leaves Cabbage leaves have been successfully used in the form of compresses in the treatment of psoriasis. The thickest and greenest outer leaves are most effective for use as compresses. They should be thoroughly washed in warm water and dried with a towel. The leaves should be flattened, softened and smoothed out by rolling them with a rolling pin after removing the thick veins. They should be warmed and then applied smoothly to the affected part in an overlapping manner. A pad of soft woolen cloth should be put over them. The whole compress should then be secured with an elastic bandage. 2. Bitter Gourd Bitter gourd is a valuable remedy for psoriasis. A cup of fresh juice of this vegetable, mixed with a teaspoon of lime


Q:

What am I doing wrong in my basic bubble sort?

I am trying to make a basic bubble sort and count the number of passes and swaps it takes to complete.
So for the example input:
23 - This is just the amount of numbers below.. Don't ask why I can't just use the len()
20 18 8 11 17 12 13 21 10 14 9 5 19 6 16 7 2 15 1 3 22 4 23
def bubbleSort(amount, numbers):
    sorted = False
    swapCount, passCount = 0,0

    while not sorted:
        sorted = True
        for i in range(amount-1):
            ifof the shaped fingers.
A MEMS mirror device fabrication method is disclosed using a single substrate. A pattern is formed on the substrate such that the pattern is used to define a frame pattern, electrostatic actuators, mirror component, and support structure. Portions of the substrate are removed selectively using the pattern to form the frame pattern, electrostatic actuators, mirror component, and support structure such that the electrostatic actuators define a gap that decreases along a direction perpendicular to a surface of the mirror component.
An electrostatic actuator fabrication method for a MEMS mirror device is disclosed. Two or more shaped fingers are formed from a single substrate. The shaped fingers are formed to define a gap between the fingers that decreases along a direction perpendicular to a top surface of


the idea for Soul River Inc. He knew the river had saved his life, but he wanted to help other people find their own version of fly fishing, that which could soothe the wounds left by trauma.

"Your soul river is different than my soul river," he said. "Your soul river may be hiking or skateboarding, but its the idea being able to connect on a personal level that you can use as a coping mechanism to help you go through your process."

The next year, he finally got his paperwork from the VA diagnosing him as 50 percent mentally disabled. With that diagnosis came roughly six years of backpay and a chance for Brown to start over again. He paid off some debt he'd accumulated, and sunk the restnot change significantly. When HCC1937 was treated with different concentrations of olaparib, it was found that APE1 expression decreased more significantly at 15 μM of olaparib was. In HCC1937-APE1-KO, the expression of endogenous poly (ADP-ribose) polymerase 1 was also less than that of HCC1937. These results suggested that the expression of APE1 was an important basis for the maintenance of poly (ADP-ribose) polymerase 1, and the deletion of APE1 may be related to the resistance of olaparib.


the highest rate in over 25 years.
Manufacturing employment declined by 168,000 in February and
has dropped by 1.3 million since the start of the recession.
Employment has fallen in nearly all manufacturing industries
during this period. In February, manufacturing hours decreased
by two-tenths of an hour, as did factory overtime hours.
Construction employment fell by 104,000 in February with
losses throughout the sector. This industry has shed 904,000
jobs since the recession began, with about half of the decline
occurring in the past 4 months.
In February, employment continued to decline sharply
throughout most of the service-providing sector. Professional
and business services employment dropped by 180,000, including
78,000 jobs lost at temporary help agencies. Employment in
temporary help has fallen by 686,000 since the recession began.
Other large over-the-month job losses occurred in transportation
and warehousing (-49,000), especially trucking; financial
activities (-44,000); retail tradehis company and affiliates could solve.” In an interview with OCCRP, Ziv called the allegations “absolutely, completely false.” The Israeli businessman said he first came to southern Sudan in 2008 to connect with the region’s leadership. “He came with a catalogue of questions, he did not come with answers,” said Costello Garang, a former advisor to South Sudan’s President Kiir, who explained that Ziv wanted to learn about the situation in southern Sudan. “Are we for unity; are we for separation? If we are for unity, what type of unity? If we are for separation, how are we going to defend it?” Ziv told OCCRP he returned in 2015 to help the now independent country “recover from the war.” “[I told them] the country cannot grow and recover


told OCCRP he was present at a meeting at Global’s office with Trafigura and the agriculture ministry both in attendance.

Blurred Lines When OCCRP visited one of Green Horizon’s four farms in 2017, Minister of Defense Kuol Manyang was there on what was described as a routine visit. The sign outside Global’s office in Juba, South Sudan’s capital, included the country’s military seal — which was removed just days after receiving questions from a reporter about the affiliation. “I don’t know why [the] defense [ministry] is involved,” said Deputy Minister of Agriculture Kornelio Kon Ngu. Global said its collaboration with the defense ministry was limited to training former soldiers to cultivate crops during a short-term project on a small plot near Juba, and that the ministry provided security forthe farms and Global’s employees. OCCRP visited the training site near Juba in late 2017 and saw about two dozen demobilized soldiers, some sitting in the fields, or perched on an idle tractor. Women, who were likely family members, rested on jerry cans in the grass by a series of thatched huts across the road. Emails between Global employees in August 2015 also suggested that Trafigura’s activities with the Israeli company involved the defense ministry. In one, a Global employee requested that a letter from Trafigura about contacts and negotiations with the Ministry of Petroleum and Mining be passed onto the defense minister for “his knowledge.” “If everything goes well we will come next week to sign the agreements and launch the Agriculture project,” the Global employee wrote.


that’s because Global’s farming project bypassed parliament as “a special case.” Mathew Gordon Udo, who has been undersecretary at the Ministry of Agriculture and Forestry for close to a decade, said that $35 million was allocated to the project and another $10 million to the veteran training site, though Udo added he knew neither what happened to the second allocation nor how the $35 million were spent. If added together, the two figures match the $45 million Ziv said he received and that the finance ministry ordered transferred to Global for Green Horizon. Credit: Edin Pasovic / OCCRP Locations of Green Horizon farms. Click to enlarge. An internal Global email described how the company sought another $44 million just four months into the project “for the second phase.”knowledge of the project, and queries directed to government offices provided no clarity. Officials at the justice and finance ministries didn’t comment on the record, while officials at the agriculture ministry said they could not account for how the funds were spent. 🔗Lack of Transparency South Sudan’s agriculture ministry has had a permanent representative in Global’s office in Juba since the farming scheme began in 2015. But, though Erneo Balasio Peter Tombe is Green Horizon’s government coordinator, he has little insight into its finances, which he said are all processed in Israel. While Global had provided reports about its agricultural work to the ministry over the years, Tombe admitted that the company has yet to deliver a “holistic” breakdown of the $35 million the main farming project received.


Their misfortune was our luck: 180 million years later, we can see details of their macro and micro anatomy so well that we can see how uncannily similar they are to their living descendants, royal and cinnamon ferns. They could be sisters!

Incidentally, here is what a cinnamon fern looks like today. The brown spikes are the reproductive fronds loaded with spores. You would not be out of place picturing a giant dinosaur foot resting right behind this shrub.

Alive and well. "I wanna live with a cinnamon fern, I could be happy the rest of my life, with a cinnamon fern". "Cinnamon fern" by Physics major - en:File:Cinnamon fern.jpg. Licensed under Public domain via Wikimedia Commons.

Fossils from the family this fern belongs to had already been found from 220living cinnamon fern Osmundastrum cinnamomeum.

The results, the authors say, demonstrate that royal ferns and their fossilized relative are comparable with regard to these parameters and probably shared the same chromosome count and DNA content, making them a "notable example of evolutionary stasis among plants."

Although the term "living fossil" has fallen into disrepute among scientists and science writers of late, I have argued for its continued use in the past and I continue to maintain it has value as long as the user explains the term doesn't mean that the plant and its ancestor are literally identical. No plant, animal, or microbe, can remain untouched by 180 million years of evolution, no matter how little their appearance and genome size have changed.

But like horseshoe crabs, sharks, and coelacanths, and


formation in HK-2 cells were measured at 24 h reperfusion. **c** Western blot analysis of hiPSC-MSCs-EVs shows expression of SP1 protein. **d** The relative SP1 protein expression in HK-2 cells was measured by western blot. **e** The relative SP1 mRNA expression in HK-2 cells was measured by real-time PCR. **f** The relative SK1 promoter activity in HK-2 cells was evaluated by luciferase assay. Data are presented as means ± SEM; the results were from three independent experiments; statistical significance: \**p* \< 0.05; \*\**p* \< 0.01, \*\*\**p* \< 0.001

To further investigate the mechanism by which hiPSC-MSCs-EVs induce increase SK activity, the content of hiPSC-MSCs-EVs was analyzed and found that EVs contained abundant amounts of specificity protein 1 (SP1), a potential transcript factor of SK1, but no detectable SK1 (Figure [4c](#Fig4){ref-type="fig"}). Furthermore, the level of SP1 in HK-2 cells wasJapan).

Flow cytometry {#Sec18}
--------------

To analyze the characteristics of cultured hiPSC-MSCs, cells were incubated with 1% BSA for 30 min (Gibco) in PBS to block nonspecific antigens. Conjugated monoclonal antibodies (PE-CD34, PE-CD45, APC-HLA-DR-PE, FITC-CD29, FITC-CD90, and FITC-CD105; Biolegends) were used according to the manufacturer's instructions. To evaluate the apoptosis level of HK-2 cells, we analyzed the percentage of the early apoptotic cells using an Annexin V-FITC apoptosis detection kit according to the manufacturer's instructions. The samples were analyzed using an Epics xL flow cytometer (Beckman Coulter, High Wycombe, UK).

Multipotential of hiPSC-MSCs {#Sec19}
----------------------------

Osteogenesis and adipogenesis were examined to determine the multipotential of hiPSC-MSCs. For induction, 1 × 10^5^ hiPSC-MSCs were seeded in 24-well plates until they reached 80% confluency, at which point the medium was replaced with osteogenesis medium or adipogenesis medium (ThermoFisher). The


morphology was visualized by transmission electron microscopy. Briefly, EVs were diluted to 1 mg/ml with PBS. Then, a specimen of EVs was spotted onto a glow-discharged copper grid on the filter paper and dried for 20 min under infrared lamp. Finally, the grid was stained with 2% uranyl acetate at pH 7.0 for 40 s and air-dried at room temperature. EVs were examined under transmission electron microscopy (H-600 HITACHI microscope, Japan) at 80 keV. The size of the EVs was determined using a Zetasizer Nano (Malvern Instruments, Malvern, UK), and the purity was assessed by western blot with EVs markers (Alix, CD63, and CD81). The number of EVs was assessed by the CD81-antigen ELISA kit (ThermoFisher).

Cell culture and H/R treatment {#Sec22}
------------------------------

The human renal proximal tubular cell line HK-2 was obtained from American30 min, then 95 °C for 5 min, followed by a ramp to 25 °C at 5 °C/min. The annealed oligo was ligated into the BbsI-digested pX330 vector using 5 μl of 2× QuickLigation Buffer and 1 μl of QuickLigase (New England Biolabs). The ligation mixture was treated with Plasmid Safe exonuclease (Epicentre) and transformed in OneShot chemically competent Stbl3 cells (Life Technologies). After plasmid DNA extraction (Qiagen), the sequence of the construct was verified by automated DNA sequence analysis. Secondly, HK-2 cells were cultured in six-well dishes to 70--80% confluence. Cells were co-transfected with 1 μg of SP1 sgRNA plasmid plus 1 μg of pLVX-GFP (Clontech) and 5 μl of Lipofectamine 3000/well. pLVX-GFP-derived green fluorescent protein was used as a fluorescent marker to sort transfected cells. Forty-eight hours post-transfection, cells were pelleted in PBS + 2% FBS and sorted


cuantificadores anidados. También estás teniendo un problema en tu regex, que no es evidente ahora, pero puede traerte problemas en el futuro. Al usar:
[a-zA-Z]+_?[a-zA-Z]+?

estás repitiendo consecutivamente 2 construcciones que coinciden con lo mismo. Como el _ es opcional, el regex puede convertirse en [a-zA-Z]+[a-zA-Z]+?, y una construcción así es la receta perfecta para un backtracking catastrófico!
Además, con esa misma construcción, estás exigiendo que tenga al menos 2 caracteres, por lo que no va a coincidir jamás con un texto como A_B_1.

Solución: repetir dentro del grupo. Para evitar esto, lo que hacemos es englobar a toda la parte opcional en un grupo sin captura, cuantificado con ?. Es decir:
([a-zA-Z]+(?:_[a-zA-Z]+)?)

Y aplicamos la misma lógica a la parte de dígitos (repetida con *).

Regex:
 /^([a-z]+)_([a-z]+(?:_[a-z]+)?)_(\d+(?:_\d+)*)$/i

Código:

let pruebas = [
    the PGM project will address the following three specific aims; Aim 2. To characterize key scientific concepts, social determinants, public understandings, and professional attitudes that will Impact the translation of genomic research to personalized medical services, including beliefs about the goals of translational genomic research, commercial incentives, and health care provider attitudes about personalized genomic services. Aim 1. To understand stakeholder understandings of the promises and perils of the forms of personalized genomic medicine envisioned in each case. Aim 3. To evaluate the extent to which the social and ethical risks potentially associated with PGM's virtues will be exacerbated or mitigated by the stakeholder interests we identify, in order to suggest the health policy and medical practice choices that will have to be made as TGR approaches the


been left behind by our own world.

As the complexities of the hyper-networked world exponentially compound beyond the ability of anyone to fully grasp, it’s unsurprising that the broader political culture should tumble backward into familiar moral narratives, familiar villains, all bolstered by the mediated opportunity to link, link, link, link. As networks and capital burrow through the borders between states, perforating the demarcations between power structures and between people, tales of conspiracies pop up, pulling back against that diffusion like a contracting fist.

The type of systems complexity that is emerging — where financialized markets support automated production, shipping, delivery, and disposal; where entire landmasses are hollowed out or drowned to fulfill fiduciary duties to distant shareholders — doesn’t necessarily need human or democratic engagement to persist. Unfortunately, thelink by link by link. But the conspiratorial tales people tell, the ones that aim to comfort through narrative reassurances of the centrality of humans in our own world, will always be more compelling than the reality of a complex world running away without us.


the worksheet was not attached.

 -----Original Message-----
From: 	Johnson, Rudwell
Sent:	Friday, July 06, 2001 2:15 PM
To:	Perlingiere, Debra
Cc:	Pollan, Sylvia S.
Subject:	Metropolitan MP

Debra!

Please find attached a credit worksheet for the listed counterparty.   Kindly prepare a Enfolio master physical contract and forward to the listed contact.

Thanks
Rudwell.by American Rifleman Staff - Tuesday, May 29, 2018

The Bureau of Alcohol, Tobacco, Firearms and Explosives NFA Branch plans to spend $13.2 million and add 25 new positions during Fiscal Year 2019 for additional equipment, software updates, contract support and NFA system modernizations. The enhancements are expected to reduce processing time for NFA applications to within a 90-day timeframe. atf.gov


the PK column (4484319 here) and auto inserts 4484320 without explicitly mentioning the same?
Note: Our DB has hundreds and thousands of records.
I think there's something similar to (SELECT MAX(ID) + 1 FROM MyTable) which could potentially solve my problem but I don't know how to use it.

A:

Multiple tables use the same sequence of auto-generated primary keys when user creates a static data record from the GUI.

Generally, multiple tables sharing a single sequence of primary keys is a poor design choice. Primary keys only need to be unique per table. If they need to be unique globally there are better options such as UUID primary keys.
Instead, one gives each table their own independent sequence of primary keys. In MySQL it's id bigint auto_increment primary key. In Postgres you'd use         "entityByReference": {
              "allowReference": true
            }
          }
        },
        {
          "entity": {
            "entityReference": "RAssetTable"
          },
          "name": "Relationship_RAssetTableRelationship",
          "resolutionGuidance": {


that include major resources industry corporations on their client lists.

Take former Foreign Minister Alexander Downer, for example. Mr Downer is a registered lobbyist with Bespoke Approach, which includes the likes of Xstrata, Petrochina and Yancoal among its clients. Also at Bespoke is Nick Bolkus, a former minister in both the Hawke and Keating Governments.

Lobby company SAS Consulting includes two former ministers, Con Sciacca and Larry Anthony, and former MP Phil Barresi. Sciacca’s former Chief of Staff Luke Giribon also works at SAS, which includes gas and electricity company ERM Power and the group of companies owned by coal mining magnate Nathan Tinkler.

Also lobbying for GRA and its partner company GRA Everingham is John Dawkins, who left politics in 1984 after 18 years as an MP and minister.

None of“1” tacked on to the end there, Elon doesn’t want this to be the only Gigafactory.

In a Q&A, Elon confirmed that he wants to build Gigafactories in other countries. And he wants to build Gigafactories that handle both halves of the Tesla manufacturing equation — building the batteries AND building the cars. Currently, that job is set to be split between its car plant in Fremont, CA and Gigafactory 1 in Nevada. This one is in the U.S. because that’s where it needs the most batteries; as other countries show demand, they’ll build Gigafactories there.

Even on the walls of the factory, it’s “Gigafactory 1”

But first, Elon needs to prove that this first $5 billion bet pays off.

It needs to help Tesla hit that 500,000-cars-per-year-by-2020 goal. It needs to


[Left-ventricular relaxation in patients with ischemic heart disease, congestive cardiomyopathy and mitral and aortic valve defects].
Left ventricular relaxation was studied in 105 patients with coronary heart disease (CHD), 42 with mitral and aortic valvular diseases, and 14 with congestive cardiomyopathy. To assess the left ventricular relaxation, the values of dP/dt and T time constants for isovolumic exponential fall in intraventricular pressure were defined in the patients. Depressed left ventricular relaxation was found in the majority of the patients with CHD whatever the status of global and segmental pumping function of the left ventricle. Abnormal left ventricular relaxation turned out to be a characteristic feature in patients with congestive cardiomyopathy and valvular diseases that contributed to the generation of left ventricular overload by its pressure and volume. In CHDMonitoring the implementation of the State-Regional Council agreement 03/02/2005 as to the management of acute stroke events: a comparison of the Italian regional legislations.
Access to effective acute stroke services is a crucial factor to reduce stroke-related death and disability, but is limited in different parts of Italy. Our study addresses this inequality across the Italian regions by examining the regional legislations issued to adopt and implement the State-Regional Council agreement 03/02/2005 as to the acute stroke management. All decrees and resolutions as to acute stroke were collected from each region and examined by the means of a check list including quantitative and qualitative characteristics, selected in accordance with the recommendations from the State-Regional Council document. Each completed check list was then sent to each regional reference person, who


filled in the section on the implementation of the indications and compliance, with the collaboration of stroke specialists if necessary. The study was carried out from November 2009 to September 2010. The documents and information were collected from 19 regions. Our survey revealed disparities both in terms of number of decrees and resolutions and of topics covered by the regional legislations about stroke care. Most legislations lacked practical and economical details. This feedback from national and regional stroke regulations revealed a need of more concrete indications. Involvement of various stakeholders (legislators, consumers, providers) might possibly ensure that policies are actually adopted, implemented and maintained. Although considerable challenges are present to the development of standard and optimal stroke care more widely across Italian regions, the potential gains from suchthan that of the frame or door construction in which the impact girder is incorporated.
During a collision process, however, before complete deformation of the structure, the resistance to deformation of the impact girder should not be so high that the supporting beams or frame parts will be deformed or the impact girder torn from the body of the vehicle.
The customary impact girders show an increased resistance to deformation during the deformation process. As a consequence, the resistance to deformation cannot at the start of such deformation be only slightly smaller than the deformation resistance of the supporting beams and frame parts. Hence the initial resistance to deformation of the impact girder may be substantially smaller than is desirable. It is also desirable to provide an impact girder whose


have all the prep time in the world and you're given all the money and everything you want, you can have this vision that basically is cast in concrete. And what happens is, when you get on the set and things start to go wrong, you have this death-grip on your vision. At some point you have to recognize, 'OK, I have to be flexible about my vision because what I thought I had, I don't have. I've got something different, so how do I adapt to those changes?’”

Some of that adaptation was taking place in the editing room even as Johnston spoke. Editor Goldblatt "was doing stuff that I didn't want Walter [Murch] to do, because the studio said, 'Can we try this, can we try that?'1866. The bonds in this case were issued in No payments of prin. cipal or interest have been made. They are payable 48 months afte\ date, with interest at 6 per cent. per annum, payable semi-annually. Some of the bonds have interest coupons, and the interest is payable "on presentation of proper coupon." Others are without coupons, and provide upon their face for the semi-annual payment of interest. The validity of the proceedings, of the order for the improvement, and of the assessment under which the bonds sued upon were issued, was contested, and during the litigations, which continued until late in the year 1877, no assessments were collected. The first payment into the county treasury on account of assessments was in February, 1878, and until then there


upon this point. In construing the statutes of a state, the United States courts adopt and follow the decisions of the courts of the state. There is another consideration which, in view of the reasoning of the court in Cook v. Conrtright, cited above, sheds light upon this branch of the case. The county commissioners were authorized to issue the bonds of the county, payable in installments, or at intervals, not extending in all beyond the period of five years. They could, if they saw fit, make them payable, some in one month, some in three months, some in six months, and others at any other intervals within five years,-all bearing interest at 6 per centum per annum,-and thus provide for the payment of interest monthly or quarterlylife last September.

An inquest into the death heard that 18 year old Jayden Lowe was spending £30 per month on hormone treatment and receiving testosterone by mail. However, Jayden’s mother, Claire Lowe, has called for a second inquest after discovering that Jayden had received the hormone treatment from GenderGP, which operated without a licence between March 2017 and February 2018.

The website was run by husband and wife, Mike and Helen Webberley, who were associated with the charity Mermaids. They have both been suspended by the British Medical Council, pending investigation, but Helen Webberley, who treated children as young as twelve, has already been found guilty of illegally providing healthcare services from her home.

1st July

FairPlayForWomen published a guest post by the Greater Manchester Resisters called “Are Lesbians Welcome at


  public job_family()
    {
        this.t_actual_organization = new HashSet<t_actual_organization>();
        this.t_actual_organization_split_position = new HashSet<t_actual_organization_split_position>();
        this.functions = new HashSet<function>();
    }

    public int job_family_id { get; set; }
    public string job_family_name { get; set; }
    public Nullable<int> functional_area_id { get; set; }

    public virtual functional_area functional_area { get; set; }
    [System.Diagnostics.CodeAnalysis.SuppressMessage("Microsoft.Usage", "CA2227:CollectionPropertiesShouldBeReadOnly")]
    public virtual ICollection<t_actual_organization> t_actual_organization { get; set; }
    [System.Diagnostics.CodeAnalysis.SuppressMessage("Microsoft.Usage", "CA2227:CollectionPropertiesShouldBeReadOnly")]
    public virtual ICollection<t_actual_organization_split_position> t_actual_organization_split_position { get; set; }
    [System.Diagnostics.CodeAnalysis.SuppressMessage("Microsoft.Usage", "CA2227:CollectionPropertiesShouldBeReadOnly")]
    public virtualThe first sliding clamp structure determined was *E*. *coli* β \[[@pone.0154899.ref008]\]. Representative crystal structures of human \[[@pone.0154899.ref009]\], yeast \[[@pone.0154899.ref010]\], and archaeal PCNA \[[@pone.0154899.ref006]\], phage T4 gp45 \[[@pone.0154899.ref011]\], and others have also been solved. Bacterial DNA clamps observed to date form head-to-tail homodimers, with each protomer containing three copies of the "DNA-clamp" motif. PCNA and phage homologs are composed of three monomers, each containing two copies of the "DNA-clamp" domain. Thus, all of these DNA clamps have pseudo six-fold symmetry. Individual DNA-clamp domains consist of two α-helices and two β-sheets. Interactions between adjacent domains involve packing of adjacent α-helices and the formation of a continuous curved β-sheet spanning across the domain boundaries ([Fig 1D](#pone.0154899.g001){ref-type="fig"}). Recently, PCNAs from *Sulfolobus tokodaii* (stoPCNA2 and stoPCNA3) were observed to form a heterotetramer proposed


Structures were embedded in cubic water boxes. Sodium and chloride ions were added (target salt concentration 100 mM) such that the systems had zero net charge. All simulations were run as NpT ensembles (temperature 310 K; pressure 101.325 kPa) with periodic boundary conditions. Temperature was controlled using Langevin dynamics (damping constant 5 ps^--1^). Pressure control used the Nosé-Hoover Langevin piston (period 100 fs; decay rate 50 fs). A multiple time-step approach was used with 1, 2, and 4 fs for bonded, non-bonded and long-range electrostatic calculations respectively. The Particle-mesh Ewald with a grid resolution of ≤ 1 Å was used to calculate long-range electrostatic forces. van der Waals' interactions were smoothly scaled to zero between 10 and 12 Å. All systems in this study were subjected to energyHALIFAX - Another great white shark has been detected off Nova Scotia.

A tag attached to Savannah, a 210-kilogram shark, pinged Monday morning off Barren Island on the province's eastern shore.

It joins a 600-kilogram tagged shark named Hilton, who has spent more than a week along Nova Scotia's south shore, and most recently pinged Monday night off Peggy's Cove outside Halifax.

Both sharks were tagged by the research group Ocearch, and are being watched closely through an Ocearch tracking map and their own Twitter feeds with thousands of followers.

Ocearch chair Chris Fischer has said the sharks could be using Nova Scotia's Sable Island as a place to mate.

The sharks are also likely drawn to the province to feed on seals.

On Tuesday, Hilton's Twitter feed responded to a tweet showing seals


}
    }

    private void writeProblems(final Collection<RobotProblemWithPosition> problems) throws IOException {
        for (final RobotProblemWithPosition problemEntry : problems) {
            final ProblemPosition position = problemEntry.getPosition();
            final RobotProblem problem = problemEntry.getProblem();
            final Severity severity = problem.getSeverity();
            writer.append(Strings.repeat(" ", 4) + "<error line=\"" + position.getLine() + "\" message=\""
                    + xmlAttrEscaper.escape(problem.getMessage()) + "\" severity=\""
    several pathological hallmarks of COPD and on lung function. To achieve this goal, we exposed βENaC-Tg mice and wild-type (WT) littermates to air or CS for 4 or 8 weeks and determined mucin expression, goblet cell metaplasia, pulmonary inflammation, lymphoid follicles, pulmonary emphysema and airway wall remodelling, and measured lung function.

Methods {#sec007}
=======

Details of materials and methods used can be found in the online supplement ([S1 File](#pone.0129897.s005){ref-type="supplementary-material"}).

Primary tracheal epithelial cultures {#sec008}
------------------------------------

For each experiment, freshly excised tracheae were collected and pooled from 10 mice per group. Epithelial cells were isolated and cultured on membranes (T-Col, Costar, Cambridge, MA) under air-liquid interface conditions as described previously \[[@pone.0129897.ref022]\], and cultures were studied after reaching confluence (14 days).

Measurement of airway surface liquid height {#sec009}
-------------------------------------------

Primary tracheal epithelial cultures were washed with PBS, and 20


21.0, Chicago, IL, USA) was used to perform non-parametric tests (Kruskall-Wallis and Mann-Whitney-U). Reported values are expressed as mean ± SEM. P-values \< 0.05 were considered to be significant.

Results {#sec020}
=======

Overexpression of βENaC and reduced airway surface liquid height in βENaC-Tg mice {#sec021}
---------------------------------------------------------------------------------

To confirm the overexpression of the β-subunit of ENaC in βENaC-Tg mice, we performed an immunohistochemical staining for βENaC on lung tissue sections from WT and βENaC-Tg mice. βENaC-positive cells were readily detected in conducting airways and alveoli in lungs of WT mice ([Fig 1A](#pone.0129897.g001){ref-type="fig"}). The intensity of the immunoreactive signal was substantially stronger in airways from βENaC-Tg compared to WT mice, consistent with a marked increase in βENaC protein in epithelial cells ([Fig 1A](#pone.0129897.g001){ref-type="fig"}).

![Overexpression of βENaC and reduced airway surface liquid height in βENaC-Tg mice.\
Immunolocalization ofmice, whereas it remained significantly reduced in βENaC-Tg mice (Fig [1B](#pone.0129897.g001){ref-type="fig"} and [1C](#pone.0129897.g001){ref-type="fig"}). Consistent with previous studies \[[@pone.0129897.ref022]\], these results demonstrate that βENaC-Tg airway epithelia fail to regulate airway surface liquid to normal levels, and that steady state airway surface liquid is reduced in βENaC-Tg compared to WT mice.

Cigarette smoke-induced mucin expression is aggravated in βENaC-Tg mice {#sec022}
-----------------------------------------------------------------------

The expression of Muc5ac and Muc5b was quantified in total lung tissue by qRT-PCR. The airway surface dehydration in air-exposed βENaC-Tg mice resulted in a higher expression of both Muc5ac and Muc5b, compared to WT mice (Fig [2A](#pone.0129897.g002){ref-type="fig"} and [2B](#pone.0129897.g002){ref-type="fig"}). Four weeks of CS exposure significantly increased the expression of Muc5ac in βENaC-Tg mice, but not in WT mice ([Fig 2A](#pone.0129897.g002){ref-type="fig"}). In contrast, CS exposure did not induce a significant upregulation


to metaplastic changes, including the formation of PAS positive storage granules \[[@pone.0129897.ref035], [@pone.0129897.ref036]\]. Taken together, our results are consistent with the observation that Muc5ac is highly inducible by noxious stimuli \[[@pone.0129897.ref020]\] and suggest that hypersecretion of Muc5ac in response to CS exposure may contribute to mucus hyperconcentration and airway surface dehydration.

Airway surface dehydration produces chronic airway inflammation in BAL in βENaC-Tg mice, with higher numbers of macrophages, neutrophils and lymphocytes compared to WT littermates \[[@pone.0129897.ref007], [@pone.0129897.ref018], [@pone.0129897.ref022]\]. Our study confirms and extends these findings by showing that BAL of βENaC-Tg mice also exhibits more dendritic cells and CD8+ T-lymphocytes. By exposing both WT littermates and βENaC-Tg mice to CS, we demonstrated that airway surface dehydration was associated with an aggravated CS-induced inflammatory response in βENaC-Tg mice. In BAL,Q:

Vista glass effect in Silverlight 2.0

I want to create a panel in Silverlight 2.0 with the same properties and look as the Vista glass region that you get as a window border.
I am especially interested in the blur and the frost effects.

A:

Here's an example of this:
http://michaelsync.net/2008/11/08/silverlight-glass-button

(source: michaelsync.net)
This example doesn't include a Blur effect, but we wont have that built in to Silverlight until v3 comes out. I think Silverlight 3 is supposed to be released by the end of July.
Anyway here's a link that shows how to use the Silverlight 3 Blur Effect:
http://www.silverlightshow.net/tips/Using-Blur-and-DropShadow-effects-in-Silverlight-3.aspx


Q:

Bootstrap responsive not centering elements below 482px

A simple page which I've designed with bootstrap framework stops becoming responsive once the screen width is below 482px? The only thing i can spot is that it stops adjusting elements once the screen reaches the width of the form input fields plus an equal amount of padding either side, thus i suspect that the issue is somehow related to the form input field width settings, but I am unsure. Can anyone help please? I have read the documentation yet i am none the wiser regarding a solution.
Here's my bootply: http://www.bootply.com/DLxLacH4Jy#

A:

The solution to the specific problem I was having in my example was that i had over complicated the form with bootstrap grid classes for screen size formats, e.g. .col-xs-4 /col-md-6president shows little affinity for ideals long espoused by conservatives: free minds, free markets and free people. At best, he has invoked these ideals in scripted settings. At worst, he has attacked them outright.

In addition to his mass-marketing of the notion that the press is the “enemy of the people,” President Trump’s impulses are generally anti-trade and anti-democratic.

Trump is not smart enough to undertake an internal purge and cannot trust his chief of staff to execute such a move because … “idiot” so this whole op-ed might be contrived by folks with other agendas. The current betting line has authorship by someone associated with Mike Pence.

In a rambling speech that took place shortly after the New York Times published a bombshell editorial written by an anonymous senior official


agenda, and win the game.

For the last year I’ve been working on Secret Hitler, a game of hidden identity where everyone claims to be on the Liberal team, but some players are secretly on the Fascist team.

It features an Investigation mechanic where a player gets the power to find out for sure what team another player is on, which is extremely valuable information, but the information comes at a cost that makes it harder to share.

Another aspect of Secret Hitler is that one Fascist player’s secret role is Hitler. If the Liberals assassinate Hitler, they win the game. But if the Fascists get Hitler elected at the right moment, the Liberals lose immediately. The drama this creates is part of what makes Secret Hitler so fun.

A brief overview:compelling mechanics in social deduction games — think of the Seer in Werewolf or Merlin in Avalon — are the ones that balance or change the flow of information in interesting ways.

You can see why Trumpists in the WH would be interested in such a game, convincing people to vote against their interests. All that one needs to do is add money, which is what will ultimately end the Trump story. Note that there are “bad liberals” as well.

Whether you believe A or B has far-reaching consequences…

So if A and B are in a dispute, which one you decide to trust has implications well beyond that one pair. If you trust A, that looks really good for C and D and really bad for E and F. But


ring is reconstructed at a deeper level, and for direct hernias, in which the "tent effect" of the prosthesis is prevented. Ninety-two primary inguinal hernias (56 indirect, 29 direct and 7 direct and indirect) in 87 patients were repaired with this technique. Seventy-nine patients were followed up from 2 to 24 months. Early complications included: 7 ecchymosis, 3 seromas, 2 subcutaneous infections, 3 testicular swellings. Incision and testicular pain for longer than 6 months occurred in 2 cases. No prosthetic infections or recurrences have been detected up to the present.   ds^2=&-U^{-1}V^{-1/2}(dt-A)^2+U^{-1}V^{1/2}dy^2
          +V^{1/2}\sum_{i=1}^8 (dx^i)^2 \\
    B_2=&U^{-1}(dt-A)\wedge dy-dt\wedge dy\,, \\
    C_1=&-V^{-1}(dt-A)+dt\,, \\
    C_3=&-U^{-1}dt\wedge dy\wedge A\,, \\
    e^\Phi=&U^{-1/2}V^{3/4}\,.
  \end{aligned}$$ Here $U$ and $V$ are harmonic functions in the eight $x^i$ directions and $A$ is a one-form satisfying the Maxwell equation. Later we will concentrate on specific examples corresponding to Gödel universes with angular momentum in one or two planes, and to the two-charge black hole, but the probe analysis is actually much more general.

We consider a supertube in this background extended in the $y$ and $t$ directions and following some closed path in the transverse space. Let us label the periodic coordinate on the supertube by


be described by some gauge theory. The simplest description of the system, as was done in [@bak] for a supertube in flat space, is in terms of a non-commutative gauge theory, where one absorbs the effect of the magnetic and electric fields in the open string metric and non-commutativity parameters [@Seiberg:1999vs]. To that end first apply a gauge transformation that sets the world-volume gauge fields to zero at the expense of the NS-NS $B$-field. Effectively the total $B$ field induced on the world volume is (after setting $E=1$) $$\hat B_2=\cP[B_2]+2\pi\alpha'F
=\left(U^{-1}\right)dt\wedge dy
+\left(U^{-1}f+B\right)\,dy\wedge d\varphi\,.$$ This gives the open string metric and noncommutative parameter [@Kruczenski:2002mn] (the lines and columns correspond to the $t$, $\varphi$ and $y$ directions) $$G^{ab}+\Theta^{ab}=
 \left(\frac{1}{g+\hat B_2}\right)^{ab}=
\frac{1}{B}
\begin{pmatrix}
-m&&-V^{1/2}&&f+Vr^2/B\cr
-V^{1/2}&&0&&1\cr
-(f+Vr^2/B)&&-1&&V^{1/2}r^2/B
\end{pmatrix}\,,
\label{open-string-metric}$$ where $$m=V^{1/2}\left(UB+2f+\frac{Vr^2}{B}\right)\,.
\label{m}$$

With this we can immediately write the low energy actionphase factor kills the terms that would otherwise be divergent.

This very peculiar type of theory, the DLCQ limit of non-commutative field theory, should represent very interesting physics, but we will not pursue it here.[^3] Instead we will study the moduli space of supertubes near this point where the compact direction becomes light-like. This will turn out to be sufficient for out purposes.

Moduli space
------------

Our main claim is that when supertubes approach the velocity of light surface, they delocalize, forming a domain-wall on the velocity of light surface. This is very similar to the enhançon mechanism, where a D6-brane wrapping a K3 surface becomes delocalized over a 2-sphere, again forming a domain-wall [@enhancon]. In that example the gauge theory was quite well understood, and the enhançon point corresponds to a


$$U=1+\frac{Q_s}{R^2}\,,\qquad
    V=1+\frac{Q_0}{R^2}\,,\qquad
    A=-\frac{Jr^2}{2R^4}\sigma_L^3\,.
 \label{5metin}$$ This is a deformation of the five dimensional Gödel universe of type IIA (eq (2.46) of [@harmark]). The only difference being that $U$ and $V$ are not unity, but other constants.

The general supertube ansatz is described by harmonic functions and a Maxwell field, so all the solutions have simple analogs in electromagnetism. The three dimensional example in the previous section is analogous to a charged solenoid. The harmonic functions outside the domain-wall are the same as one would take for a charged cylinder in four dimensions. The gauge field gives a constant magnetic flux inside. The example at hand also has an analog, in electromagnetism in five dimensions.

Since there are nowhere vanishing vector fields on $S^3$, one mayif the branes make up $N$ bound states (i.e. $N$ supertubes), the bound on the angular momentum is $J\leq Q_0Q_s/N$, or $J\leq
R^2N$. We see that our solution saturates this bound.

We may look at a more general solution, where we put the domain-wall at a larger radius. Let us still take the same form for the exterior metric, and by continuity find the same form for the metric inside. The only difference is that the radius $R$ will be greater than before. Note that in the interior metric the rotation is proportional to $A=-Jr^2/(2R^4)$, and due to the negative power of $R$, this Gödel space in the interior has a smaller rotation parameter than the case above. This solution will be totally causal, with no closed time-like curves either


average over the value of this modulus, this supertube will smear over the entire surface of the $S^3$ domain-wall.

There is a chain of dualities [@Lunin:2001jy; @lmm] that takes the supertube to the D1-D5 system. If we apply this transformation to the above metric, the exterior would be the limit of the BMPV black hole with no linear momentum, which has eight supersymmetries. The duality replaces the fundamental strings with the D1-branes, so $U$ will be the relevant harmonic function, while $V$ is the harmonic function for the D5-branes, which are dual to the D0-branes in the IIA picture. The metric is given by $$\begin{aligned}
ds^2=&U^{-1/2}V^{-1/2}\left[-(dt-A)^2 +(dy+B)^2\right]
\\&
 +U^{1/2}V^{1/2}\left[dr^2+r^2d\theta^2+r^2d\phi^2
 +r^2d\psi^2+2r^2\cos\theta\,d\phi d\psi\right]
 +U^{1/2}V^{-1/2}\sum_{i=1}^4(dx^i)^2\,,
\\
 C_2=&U^{-1}\left(dt\wedge B+dy\wedge A+2A\wedge
 B+(U-1)dt\wedge dy\right) +{\cal C}
\\
 e^{2\Phi}=&U/V\,.
\end{aligned}$$ The field strengths $dA$ and $-dB$ are Hodge dual in theand place the domain wall there. By putting all the charges on the domain-wall we can find what the metric would be inside. The result is $$\begin{aligned}
 ds^2=&f_1^{-1/2}f_5^{-1/2}\left[-\left(dt+cr^2\sigma_L^3\right)^2
 +\left(dy+cr^2\sigma_L^3\right)^2
 +\frac{Q_k}{R^2}(dy-dt)^2\right]
\\&
 +f_1^{1/2}f_5^{1/2}\left[dr^2+r^2d\theta^2+r^2\sin^2\theta d\phi^2
 +r^2\cos^2\theta d\psi^2\right]
 +f_1^{1/2}f_5^{-1/2}dx_i^2\,,
\\
 C_2=&f_1^{-1}\left(dt\wedge dy+cr^2\sigma_L^3\wedge(dy-dt)\right)\,,
\\
e^{2\Phi}=&f_5^{-1}f_1\,.
\end{aligned}$$ But now $f_1$ and $f_5$ are constants. Like in the previous examples this is a metric that if analytically continued will have closed time-like curves, and has no localized sources. It is a Gödel-like metric which also carries momentum. This is an example of the mixed Gödel/pp-wave metrics found in [@harmark] (see for example their equation (2.50)).

One can again check the junction condition across the interface, and indeed in the dual type IIA metric the stress-energy tensor includes only terms related to the fundamental strings, D0-branes and D4-branes as well as


and J. Polchinski, “Compactification in the lightlike limit,” Phys. Rev. D [**59**]{}, 125002 (1999) \[arXiv:hep-th/9711037\].

M. Hayakawa, “Perturbative analysis on infrared and ultraviolet aspects of noncommutative QED on $R^4$,” arXiv:hep-th/9912167.

A. Matusis, L. Susskind and N. Toumbas, “The IR/UV connection in the non-commutative gauge theories,” JHEP [**0012**]{}, 002 (2000) \[arXiv:hep-th/0002075\].

O. Aharony, M. Berkooz and N. Seiberg, “Light-cone description of (2,0) superconformal theories in six dimensions,” Adv. Theor. Math. Phys.  [**2**]{}, 119 (1998) \[arXiv:hep-th/9712117\].

O. Aharony, J. Gomis and T. Mehen, “On theories with light-like noncommutativity,” JHEP [**0009**]{}, 023 (2000) \[arXiv:hep-th/0006236\].

D. s. Bak and A. Karch, “Supersymmetric brane-antibrane configurations,” Nucl. Phys. B [**626**]{}, 165 (2002) \[arXiv:hep-th/0110039\].

D. Mateos, S. Ng and P. K. Townsend, “Tachyons, supertubes and brane/anti-brane systems,” JHEP [**0203**]{}, 016 (2002) \[arXiv:hep-th/0112054\].

D. s. Bak, N. Ohta and M. M. Sheikh-Jabbari, “Supersymmetric brane anti-brane systems: Matrix model description, stability and decoupling limits,” JHEP [**0209**]{}, 048 (2002) \[arXiv:hep-th/0205265\].

D. Bak, Y. Hyakutake and N. Ohta, “Phase Moduli Space of Supertubes,” arXiv:hep-th/0404104.

R. Emparan and H. S. Reall, “A rotating black ringNew GUARDIANS OF THE GALAXY International Trailer Features More Rocket Raccoon

Marvel has released a new Guardians of the Galaxy international trailer that features more Rocket Raccoon, less classic rock, and additional focus on the story. While I was already sold on director James Gunn’s intergalactic adventure, this new trailer will get a lot more regular moviegoers excited for the movie. As most of you know, the story follows five intergalactic misfits—Peter Quill aka Starlord (Chris Pratt), Gamora (Zoe Saldana), Drax the Destroyer (Dave Bautista), Groot (voiced by Vin Diesel), and Rocket (voiced by Bradley Cooper)—as they set out to recapture a powerful and mysterious orb from the villainous Ronan the Accuser (Lee Pace).

Hit the jump to check out the new Guardians of the Galaxy international trailer and click


it has an adverse impact on his own rights; as a general rule, if there is no constitutional defect in the application of a statute to a litigant, he does not have standing to argue that it would be unconstitutional if applied to third parties in hypothetical situations." In State v. Wilkerson, 54 Ala. App. 104, 305 So.2d 378, 380, cert. denied, 293 Ala. 774, 305 So.2d 382 (1974), in finding that the appellant could not challenge the constitutionality of a statute because he could not show that the statute's unconstitutional feature adversely affected him, we cited the general rule, as follows:
"`... in criminal prosecution, accused has the right to assert the invalidity of the law, regulation, or rule under which he is being prosecuted, but he mustvote while Abrams held 48.8 percent, putting her one-third of a percentage point away from being able to demand a run-off election.

"I am fighting to make sure our democracy works for and represents everyone who has ever put their faith in it. I am fighting for every Georgian who cast a ballot with the promise that their vote would count." —Stacey Abrams

SCROLL TO CONTINUE WITH CONTENT Never Miss a Beat. Get our best delivered to your inbox.

Many Georgians were unable to vote with an official ballot because their registration status had been changed to pending without their knowledge due to clerical errors under the state's "exact match" rule—one that had been pushed by Republican candidate Brian Kemp, Georgia's secretary of state until last Thursday. About 70 percent of


on manifolds
author:
- 'Anton Schiela & Julian Ortiz'
bibliography:
- 'mybib.bib'
title: An SQP method for equality constrained optimization on manifolds
---

Introduction
============

In an important variety of fields, optimization problems benefit from a formulation on nonlinear manifolds. Problems in numerical linear algebra like invariant subspace computations, or low rank approximation problems can be tackled using this approach, these problems are the focus of [@absil2009optimization]. Beyond that, plenty of variational problems are posed on infinite dimensional manifolds. Nonlinear partial differential equations where the configuration space is given by manifolds are found in many applications, for example in liquid crystal physics [@prost1995physics] and micro-magnetics [@alouges1997new; @alouges2012convergent; @bartels2007constraint; @kritsikis2014beyond; @lin1989relaxation]. Further are Cosserat materials [@badur1989influence] where configurations are maps into the space $\mathbb{R}^3\times SO(3)$ which are particularly relevant for shell and rod mechanics. Similar insights have\to X$, which is widely used in unconstrained optimization on manifolds. For the co-domain $Y$ of the constraint mapping $c$ we also need mappings ${S}_y :Y \to T_y Y$ in the other direction, which we call *stratifications*. On Riemannian manifolds, the exponential map $\exp_x : T_x X \to X$ and the logarithmic map $\log_y : Y\to T_y Y$ are canonical examples.

\[def:retraction\] Let $V_{0_x}\subset T_x X$ be a neighbourhood of $0_x \in T_x X$. A $C^2$-mapping $R_x : V_{0_x} \to X$ is called a (local) retraction at $x$, if it fulfills:

-   $R_x(0_x)=x$.

-   $T_{0_x}R_x=id_{T_xX}$.

If $V_{x_0}=T_x X$, we call $R_{x}$ globally defined on $T_x X$.

Let $U_{y}\subset Y$ be a neighbourhood of $y\in Y$. A $C^2$-mapping ${S}_y : U_y \to T_yY$ is called a (local) stratification at $y$,


Hilbert manifolds. For equality and inequality constrained problems on finite dimensional manifolds, where the target spaces of the constraint mappings are linear, [@HerzogBergmann2019] have shown first order optimality conditions by different techniques.

\[lem:StratRet\] Let ${\mathbf c}: T_x X\to T_{c(x)} Y$ be the pullback of $c:X\to Y$ at $x$ via $R_{x}, {S}_{c(x)}$. Assume that ${c}'(0_x)$ is surjective. Then there is a local retraction $R_{x,0}$, such that $$\label{eq:stratretr}
   {\mathbf c}_0(\delta x)={\mathbf c}_0(0_x)+{c}'(0_x)\delta x  \quad \forall \delta x\in U.$$

By the surjective implicit function theorem (cf. e.g. [@ZeidlerI Thm. 4.H]), which is applicable in Hilbert space, there is a neighbourhood $U$ of $0_x$ and a mapping $\phi :U \to T_x X$, such that ${\mathbf c}(\phi(\delta x))={\mathbf c}(0_x)+{c}'(0_x)\delta x$ and $\phi'(0_x)=id_{T_x X}$. Defining $R_{x,0} := \phi\circ R_{x}$ we observe by thethe corresponding unique Lagrange multiplier. It can be checked easily that ${p}_x$ satisfies $$\begin{aligned}
\label{Computation_Lag_multiplier}
{L}'(0_x,p_x)w = {f}'(0_{x}) w+{p}_x{c}'(0_{x})w=0_x^* \quad \forall w\in \ker {c}'(0_{x})^{\perp}\end{aligned}$$ and we can write in short: $$p_{x}=-{f}'(0_x){c}'(0_x)^-.$$ Since ${L}'(0_x,p)v={f}'(0_x)v$ for $v\in \ker {c}'(0_x)$ and any $p\in T_y Y^*$, implies a minimum norm property: $$\label{eq:pminnorm}
 \|{L}'(0_x,p_x)\|_{x,*}\le\|{L}'(0_x,p)\|_{x,*} \quad \forall p\in T_y Y^*.$$ Since the data involved in does not depend on the chosen retraction and stratification, $p_x$ is invariant under a change of retractions and stratifications, but it does depend on the chosen norm. Moreover, if $0_x$ satisifies the first order optimality conditions, then ${L}'(0_x,p_x)=0$.

More generally, for any $v_x\in T_x X$ $${\mathbf f}'(v_x)w+p_{v_x}{\mathbf c}'(v_x)w=0_x^* \quad \forall w\in \ker\,{\mathbf c}'(v_x)^\perp$$ is equivalent to $$\label{eq:pxshort}
 p_{v_x}=-{\mathbf f}'(v_x){\mathbf c}'(v_x)^-.$$

#### Tangential step.

For $\delta x\in T_x X$ consider the unique orthogonal splitting $\delta


trust-regions, or cubic regularization), and propose an update $\delta x=\delta n+\delta t$. We will return to this topic in Section \[sec:global\].

A local SQP-Method {#sec:convergence}
==================

Let us briefly recapitulate our construction as follows. Starting from a problem on nonlinear spaces: $$\min_{x\in X} f(x) \mbox{ s.t. } c(x)=y_* \mbox{ where  } c : X \to Y$$ we first *linearize the spaces* via ${R_{x}}, {S_{c(x)}}$ at $x\in X$ to obtain a pullback on tangent spaces: $$\min_{\delta x\in T_xX} {\mathbf f}(\delta x) \mbox{ s.t. } {\mathbf c}(\delta x)=0_{c(x)} \mbox{ where  } {\mathbf c}: T_xX \to T_{c(x)}Y,$$ then we *linearize the problem* at $0_x$ via ${R^{{{\scriptscriptstyle \circ}}}_{\scriptscriptstyle x}}, {S^{{{\scriptscriptstyle \circ}}}_{\scriptscriptstyle c(x)}}$ to obtain a linearly constrained quadratic problem: $$\begin{aligned}
 \min_{\delta x\in T_x X} {\mathbf q_{{{\scriptscriptstyle \circ}}}}(\delta x) \quad \mbox{ s.t. }\quad  {c}'(0_x)\deltaguess and a vector transport for $p$. It can be seen from that the Lagrange-Newton step $\Delta x$ is independent of the choice of ${R_{x}}$.

Non-degeneracy of retractions {#sec:localNorm}
-----------------------------

While the previous chapter was concerned with computations at specific points, we now have to deal with a sequence of points to analyse convergence of Algorithm \[alg:local \_inner\_loop\_rough\]. We have to guarantee that the chosen retractions and norms do not degenerate while approaching a local minimizer $x_*$. Due to the inverse mapping theorem all retractions possess a neighbourhood $V^i_x \subset V_x$ of $0_x$, such that $R_x : V^i_x \to R_x(V^i_x)$ is a diffeomorphism and $R_x(V^i_x) \subset X$ is a neighbourhood of $x$.

If $x_*\in X$ is some desired solution, and $x\to x_*$, we expect these neighbourhoods to overlap in a larger and larger


of $x\in U_{x_*}$, such that the following estimates hold for all $x\in U_{x_*}$, and all $v,\delta x\in T_x X$ with $\|\delta x\|_x\le \rho_0$: $$\begin{aligned}
\label{eq:Lipschitzf}\|{\mathbf f}'(\delta x)-{f}'(0_x)\|_{x,*}  &\leq \omega_{{\mathbf f}'} \|\delta x\|_x,\\
\label{eq:Lipschitzc1}
{c}'(0_x) \mbox{ is surjective, }\quad \|{c}'(0_x)^{-}({\mathbf c}'(\delta x)-{c}'(0_x))v\|_x&\leq \omega_{{\mathbf c}} \|\delta x\|_x\|v\|_x,\\
\label{eq:boundc}
\mathbf{x}_*:={R_{x}}^{-1}(x_*),\quad {\mathbf c}'(\mathbf x_*) \mbox{ is surjective, }\quad \|{\mathbf c}'(\mathbf x_*)^-({\mathbf c}'(\mathbf x_*)-{c}'(0_x))v\|_x&\le \omega^*_{{\mathbf c}}\|\mathbf x_*-0_x\|_x\|v\|_x.\end{aligned}$$

While is a classical Lipschitz condition for ${\mathbf f}'$, the quantity $\omega_{{\mathbf c}}$ in is slightly non-standard. It is called an *affine covariant Lipschitz constant* for ${\mathbf c}'$, along the lines of [@deuflhard2011newton]. In this way no norms on $T_y Y$ need to be specified. Moreover, $\omega_{{\mathbf c}}$ can be estimated a-posteriori by an algorithmic parameter $[\omega_{{\mathbf c}}]$ that is adapted during the run of a globalized algorithm (see in Section \[sec:global\],triangle inequality: $$\|0_x+\Delta x-\mathbf{x}_*\|_x\le \|n_*\|_x+\|t_*\|_x\le \left(\frac{\omega_{{\mathbf c}}}{2}+\frac{M_*}{\alpha_{{\mathbf L_{{{\scriptscriptstyle \circ}}}}''}}\right)\|0_x-\mathbf{x}_*\|_x^2$$ and thus the desired result.

Finally, we exploit non-degeneracy to show that quadratic convergence can be observed for the pullback of the SQP-sequence to $T_{x_*} X$. For that we will need the local vector transport $\Theta_{x_*\to x}$ defined in .

\[thm:localNewton\] Suppose that Assumption \[ass:local1\] and Assumption \[ass:local2\] hold at a local minimizer $x_*$. Assume that $x_0$ is sufficiently close $x_*$, i.e., that $\|{R_{x_*}}^{-1}(x_0)-0_{x_*}\|_{x_*}$ is sufficiently small.

Then Algorithm \[alg:local \_inner\_loop\_rough\] creates a sequence $x_k \in X$, defined by $x_{k+1}={R_{x_k}}(\Delta x_k)$ that converges quadratically towards $x_*$. This means, if we denote $\mathbf{x}_k := {R_{x_*}}^{-1}(x_k)$ there is $\beta_*$, such that: $$\label{eq:quadraticconvergence}
   \|\mathbf{x}_{k+1}-0_{x_*}\|_{x_*}\le \beta_*\|\mathbf{x}_{k}-0_{x_*}\|^2_{x_*}.$$

Consider $x_k$ in the neighbourhood $U$ of $x_*$, used in Proposition \[pro:localNewton\]. We use non-degeneracy , and Proposition \[pro:localNewton\], denoting $\mathbf{x}_{*,k}={R_{x_k}}^{-1}(x_*)$: $$\begin{aligned}
   \|\mathbf{x}_{k+1}-0_{x_*}\|_{x_*}&=\|\Theta_{x_k\to


L}(\delta n,p_x)$ can be added easily to existing code.

Globalization by a Composite Step Method {#sec:global}
========================================

In the last section we established results, which are important ingredients for showing transition to fast local convergence of any SQP-globalization scheme. In this section, we will demonstrate for a specific example of a globalization scheme that transition to fast local convergence can indeed be shown.

Classical globalization strategies in equality constrained optimization on linear spaces rely on a combination of functional descent and reduction of residual norm $\|c(x)\|$. For example, merit functions of the form $\phi(x) := f(x)+\kappa\|c(x)\|$ weigh both quantities with a parameter $\kappa$ that is adjusted adaptively. In our setting, where $c(x)\in Y$ is an element of a manifold, $\|c(x)\|$ cannot be used straightforwardly. One possible surrogate would be to compute theDue to Lemma \[prop:LipschitzConsistency\] the acceptance test is passed, if $\delta x$ is sufficiently small. This happens after finitely many steps, because $\delta x_k \to 0$. Thus, in the following we may assume that $k$ is sufficiently large to have $\nu_k=1$ and $\delta x_k$ satisfies the third line of and passes .

It remains to show $\lim_{k\to \infty}\tau_k=1$. Since $\Delta x_k$ minimizes ${\mathbf q_{{{\scriptscriptstyle \circ}}}}$ on $\Delta n_k+\ker {c}'(0_{x_k})$, we conclude that ${\mathbf q_{{{\scriptscriptstyle \circ}}}}'(\Delta x_k)$ vanishes on $\ker {c}'(0_{x_k})$. This implies: $$\begin{aligned}
0={\mathbf q_{{{\scriptscriptstyle \circ}}}}'(\Delta x_k)\Delta t_k&=({f}'(0_{x_k})\Delta t_k+{\mathbf L_{{{\scriptscriptstyle \circ}}}}''(0_{x_k},{p}_{x_k})(\Delta x_k,\Delta t_k)\\
&=({f}'(0_{x_k})+{\mathbf L_{{{\scriptscriptstyle \circ}}}}''(0_{x_k},{p}_{x_k})\Delta n_k)\Delta t_k+{\mathbf L_{{{\scriptscriptstyle \circ}}}}''(0_{x_k},{p}_{x_k})(\Delta t_k,\Delta t_k). \end{aligned}$$ In addition, $\tau_k$ is computed as the minimizer of the first line of along the direction $\Delta t_k$. Hence the derivative of this term in direction $\Delta t_k$ vanishes


f}}]}(\delta x)-{\hat{\mathbf q}}(\delta x_k)=\frac{[\omega_{{\mathbf f}}]}{6}\|\delta x_k\|_{x_k}^3$$ we obtain ${\mathbf f}(\delta x_k+\delta s_k) \le \mathbf{m}_{[\omega_{{\mathbf f}}]}(\delta x_k)$, if $$C\left(1+\frac{[\omega_{{\mathbf f}}]}{2\alpha_{{\mathbf L_{{{\scriptscriptstyle \circ}}}}''}}\|\delta x_k\|_{x_k}\right) \le \frac{[\omega_{{\mathbf f}}]}{6}$$ For sufficiently small $\delta x_k$ this is true, if $$\label{eq:boundomega}
 [\omega_{{\mathbf f}}] \ge \frac{6C}{1-\frac{3C}{\alpha_{{\mathbf L_{{{\scriptscriptstyle \circ}}}}''}}\|\delta x_k\|_{x_k}}.$$ Thus, we conclude that close to a minimizer always holds with $\eta \ge 1 >\hat \eta$, if $[\omega_{{\mathbf f}}]$ is above the bound, given in , which only depends on the problem and the chosen neighbourhood around $x_*$. Consequently, by our algorithmic mechanism, $[\omega_{{\mathbf f}}]$ cannot become unbounded. Hence, as $x_k \to x_{*}$, implies by that $\tau_k \to 1$ because $[\omega_{{\mathbf f}}]\|\delta x\|_{x_k}/\alpha_{{\mathbf L_{{{\scriptscriptstyle \circ}}}}''}\to 0$. Thus, we obtain local superlinear convergence of our algorithm. More accurately, by boundedness of $[\omega_{{\mathbf f}}]$ we obtain, using $\|\delta{{\mathbb{R}}}^3\\
        u &\to \mu_{v_i}(u)
 \end{aligned}$$ such that $\mu_{v_i}(0)=v_i$ and $\mu_{v_i}(u)\in \mathbb{S}^2$. Elements of $\mathbb{S}^2$ are represented as vectors $v\in {{\mathbb{R}}}^3$ with $\|v\|_{{{\mathbb{R}}}^3}=1$ via the standard embedding $\mathbb{S}^2\subset {{\mathbb{R}}}^3$. Due to this embedding, we may view $\mu_{v_i}$ as a mapping ${{\mathbb{R}}}^2\to {{\mathbb{R}}}^3$ and compute ordinary first and second derivatives.

#### Two alternative retractions.

To study the effect of consistency of retractions numerically, we will introduce two different retractions with suitable local parametrizations. The first retraction is well known and quite straightforward. The second one uses a more sophisticated computation. We introduce it in order to have two different retractions to our disposal and to demonstrate that these two can be used interchangingly, as predicted by our theoretic results.

#### Projection to the sphere.

In the following


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     <ClCompile Include="..\Modules\audioop.c" />
     <ClCompile Include="..\Modules\binascii.c" />
+    <ClCompile Include="..\Modules\bz2module.c" />
+    <ClCompile Include="$(bz2Dir)\blocksort.c" />
+    <ClCompile Include="$(bz2Dir)\bzlib.c" />
+    <ClCompile Include="$(bz2Dir)\bz2compress.c" />
+    <ClCompile Include="$(bz2Dir)\crctable.c" />
+    <ClCompile Include="$(bz2Dir)\decompress.c" />
+    <ClCompile Include="$(bz2Dir)\huffman.c" />
+    <ClCompile Include="$(bz2Dir)\randtable.c" />
     <ClCompile Include="..\Modules\cmathmodule.c" />
     <ClCompile Include="..\Modules\cPickle.c" />
     <ClCompile Include="..\Modules\cStringIO.c" />
@@ -384,9 +449,26 @@
     <ClCompile Include="..\Python\thread.c" />
     <ClCompile Include="..\Python\traceback.c" />
   </ItemGroup>
+  <ItemGroup>
+    <CustomBuild Include="..\Modules\_ctypes\libffi_msvc\win64.asm">
+   1. Field of the Invention
The present invention relates to new crystalline molecular sieve SSZ-75, a method for preparing SSZ-75 using a tetramethylene-1,4-bis-(N-methylpyrrolidium) dication as a structure directing agent (“SDA”) and uses for SSZ-75.
2. State of the Art
Because of their unique sieving characteristics, as well as their catalytic properties, crystalline molecular sieves and zeolites are especially useful in applications such as hydrocarbon conversion, gas drying and separation. Although many different crystalline molecular sieves have been disclosed, there is a confirming need for new molecular sieves with desirable properties for gas separation and drying, hydrocarbon and chemical conversions, and other applications. New molecular sieves may contain novel internal pore architectures, providing enhanced selectivities in these processes.


+ 204 = 2*g. Does 4 divide g?
True
Suppose 4356 = 16*t - 7036. Is t a multiple of 13?
False
Suppose -6*j = -61 - 11. Suppose 5*o - 4 = -14, s - j = 3*o. Does 2 divide s?
True
Let p(g) = -4*g + 2. Let l be p(3). Let b be (1 - (-40)/(-25)) + (-254)/10. Let q = l - b. Is 16 a factor of q?
True
Suppose 4*m = 287 + 137. Let p = 157 - m. Let r = p - 30. Is r a multiple of 9?
False
Suppose z - 2*q - 67 = 0, 55 = z - q - 11. Is z a multiple of 65?
True
Let i be (4/5)/2 + 894/(-10). Let v = 200 + i. Does 14 divide v?
False
Let h =specifically for random forests; we wish to extend this method for GBDTs. This involves accounting for (1) the sequential dependency between trees and (2) training on the negative gradients instead of the original labels.'
author:
- Ana Lucic
- Hinda Haned
- Maarten de Rijke
bibliography:
- 'ana-facts-ir.bib'
title: 'Explaining Predictions from Tree-based Boosting Ensembles'
---

This research was partially supported by Ahold Delhaize, the Association of Universities in the Netherlands (VSNU), the Innovation Center for Artificial Intelligence (ICAI), and the Netherlands Organisation for Scientific Research (NWO) under project nr 652.001.003. All content represents the opinion of the authors, which is not necessarily shared or endorsed by their respective employers and/or sponsors.


The primary aim of this proposal is to further our efforts to improve the treatment and care of adult patients with malignant brain tumors through continued participation as a fully funded member in the Phase I and II clinical investigations of the New Approaches to Brain Tumor Therapy (NABTT) CNS Consortium. This consortium utilizes the resources, expertise and patient populations of 10 outstanding medical institutions with experienced, multidisciplinary brain tumor programs and demonstrated ability to evaluate novel therapeutic agents and modalities in this challenging patient population. During our past 6 years of partially funded provisional membership in NABTT, Wake Forest University has demonstrated: (1) an outstanding ability to accrue adult patients with newly diagnosed or recurrent high grade astrocytomas to Phase I and II clinical trials of novela 12-3 thrashing on Wednesday.

And the very celebration set off by Altuve’s homer turned into a shameful incident that led to the firing of Brandon Taubman, Houston’s assistant general manager, on Thursday.

In the clubhouse party after Saturday’s clincher of the A.L. Championship Series, Taubman profanely gloated — repeatedly, without prompting — to a group of female reporters about the team’s acquisition of closer Roberto Osuna, who joined the team last year while serving a 75-game suspension for domestic violence. One of the reporters is known to tweet the national domestic abuse hotline number when Osuna pitches, and was wearing a purple bracelet supporting abuse victims.


an essential aspect of tumor growth. Adequate blood supply is important to the tumor to prevent hypoxia or nutrient deprivation. In this event, the tumor exploits its microenvironment by releasing signaling molecules, such as cytokines and growth factors, to activate surrounding quiescent cells, leading to an uncontrollable series of events.[56](#cam41715-bib-0056){ref-type="ref"} Ben et al[34](#cam41715-bib-0034){ref-type="ref"} suggested that NRP‐1 upregulation in PDAC was associated with increased angiogenesis due to a significantly positive correlation between NRP‐1 expression and microvessel density in PDAC tissues resected from patients. This may be attributed to enhanced VEGFR2 activation caused by the ability of NRP‐1 to act as a bridge between VEGF and VEGFR. In support of this, Miao et al[57](#cam41715-bib-0057){ref-type="ref"} demonstrated that NRP‐1 overexpression in rat prostate carcinoma cells resulted in larger tumors and significantly increased microvessel density.{#cam41715-sec-0008}

The chronic and aberrant cell proliferation that characterizes cancer cells is attributed not only to the deregulated cell proliferation, but also to the alterations in energy metabolism to facilitate cellular growth and division. Otto Warburg described a peculiar characteristic of cancer cell energy metabolism. Even in the presence of oxygen, cancer cells can reprogram their glucose metabolism by restricting metabolism mainly to aerobic glycolysis.[38](#cam41715-bib-0038){ref-type="ref"}, [59](#cam41715-bib-0059){ref-type="ref"} According to the Warburg effect, glycolysis is the main source of energy in cancer cells due to the lack of oxygen in the tumor environment, but glycolysis also occurs even when oxygen is in excess.[60](#cam41715-bib-0060){ref-type="ref"} As such, it has been demonstrated that NRP‐1 is a positive regulator of VEGF‐induced glycolysis via upregulation of hypoxia‐inducible factor 1α in pancreatic cancer.[61](#cam41715-bib-0061){ref-type="ref"} Moreover, downregulation of NRP‐1