more general metric measure Rademacher theorem. Rather, their proofs rely only on one of the preliminary results of Bate’s paper [@Bate] (that Alberti representations induce “partial derivatives” almost everywhere) – see Proposition \[prop:bate\] – and an adaptation of a principle of Preiss [@Preiss] about the structure of the space of tangent objects, Proposition \[prop:basepoint\].

We note that there are many other conditions, independent from any of those discussed above, that prevent or constrain bi-Lipschitz embeddability. In particular, the results of [@La00] and [@OS14] rest also, remarkably, on studying a single family of curves that is “thick” in some quantitative sense (although different than the senses used here). This is part of a larger program to characterize metric spaces embedding into the so-called RNP Banach spaces, and conversely to characterizeRNP-Banach spaces by the spaces embedding into them; see [@OSRN].

Corollaries of the main results {#subsec:corollaries}
-------------------------------

We view Corollary \[cor:bilip\] as a generalized non-embedding result. Since “thick" families of curves arise in many settings, it has a number of specific consequences.

### Modulus

From our perspective, the most important consequences of Corollary \[cor:bilip\] involve its relationship with a well-known way of measuring the “thickness” of a family of curves $\Gamma$ in a metric measure space $(X,\mu)$. This is the *$p$-modulus* of the family ($p\geq 1$), which we denote $\Mod_p(\Gamma,\mu)$. This notion plays a central role in the modern theory of analysis on metric spaces [@He; @HKST]. (We give a precise definition in Section \[sec:modulus\].)

In Proposition \[prop:modmeasure\] and Corollary \[cor:modmeasure\] below, we show that path families of positive modulus induce non-trivial Alberti representations.


that for each $k\leq j$, there is a $1$-Lipschitz mapping $\pi_{j,k}\colon \M_j \rightarrow \M_k$ obtained by identifying opposing points on slits of levels greater than $j$ corresponding to the same point in $\M_k$. These maps compose in the obvious way. We then define the Merenkov slit carpet $\M$ as the inverse limit of the system $$\M_0 \xleftarrow{\pi_{1,0}} \M_1 \xleftarrow{\pi_{2,1}} \M_2 \xleftarrow{\pi_{3,2}} \dots,$$ equipped with the metric $$d(x,y) = \lim_{k\rightarrow \infty} d_k(x_k, y_k)$$ for $x=(x_k)$ and $y=(y_k)$ such that $\pi_{k}(x_k)=x_{k-1}$, and similarly for $y_k$. Note that this is the limit of a bounded, increasing sequence.

In [@DEB], the present authors answered a 1997 question of Heinonen and Semmes [@HS Question 8] by proving the following.

\[cor:slitcarpet\] The slit carpet $\mathbb{M}$ does not admit a bi-Lipschitz embedding into any Euclidean space.

(Actually, the$a$* is any closed set which is a pointed Hausdorff limit of sets of the form $$\lambda_j^{-1}(A - a),$$ where $\{\lambda_j\}$ is a sequence of positive real numbers tending to $0$ as $j\rightarrow\infty$.

The collection of all intrinsic tangents of $A$ at $a$ is written ${\textnormal{Tan}}_{{\mathbb{R}}^n}(A,a)$.

An important difference between tangents and intrinsic tangents is that ${\textnormal{Tan}}_{{\mathbb{R}}^n}(A,a)$ may contain distinct elements that are isometric.

If one has a Lipschitz function defined on a subset of ${\mathbb{R}}^n$, there is also a way to pass to a tangent (or “blowup”) of the function simultaneously with the set. This is given in [@DS Chapter 8].

Let $A$ be a subset of ${\mathbb{R}}^n$ and $a\in A$. Let $f\colon A\rightarrow{\mathbb{R}}^m$ be a Lipschitz function.

Suppose that $\{\lambda_j\}$ is a sequence of positive real numbers tending to $0$ as


any $w\in\mathbb{S}^{n-1}$ and $t\leq -1$, $\Cone(w,t)={\mathbb{R}}^n\setminus\{0\}$.

Our definition of a cone departs slightly from those in [@Bate] and [@Schioppa]. In particular, our cones may have opening angle larger than $\pi$. It is clear that any cone of the types in [@Bate] and [@Schioppa] is a subset of a cone like one above.

\[def:direction\] Fix a metric space $X$, a Lipschitz map $\phi:X\rightarrow {\mathbb{R}}^n$, and a cone $C\subseteq {\mathbb{R}}^n$.

A fragment $\gamma\in\Frag(X)$ is said to be *in the $\phi$-direction of $C$* if $(\phi\circ\gamma)'(t)\in C$ for a.e. $t\in\dom(\gamma)$.

An Alberti representation $\cA = (P,\nu)$ of a measure $\mu\in M(X)$ is said to be *in the $\phi$-direction of $C$* if $P$-a.e. $\gamma\in \Frag(X)$ is in the $\phi$-direction of $C$.

\[def:independent\] Cones $C_1, \dots, C_k$ in ${\mathbb{R}}^n$ are called *independent* if each collection $$\{v_1, \dots, v_k :this, and in fact it will be occasionally convenient not to.

In the case $k=1$ of Definition \[def:independent\], one may take all of ${\mathbb{R}}^m\setminus\{0\}$ as a single independent cone. Thus, a single Alberti representation $(P,\nu)$ is independent if and only if there is a Lipschitz map $\phi:X\rightarrow {\mathbb{R}}^m$ such that $(\phi\circ \gamma)'(t)\neq 0$ for $P$-a.e. $\gamma\in\Frag(X)$ and a.e. $t\in\dom(\gamma)$.

In particular, if $X\subseteq {\mathbb{R}}^n$, then a single non-trivial Alberti representation is automatically independent. Indeed, take $\phi$ to be the identity map. Since every $\gamma\in \Frag(X)$ is bi-Lipschitz, we have that $$(\phi \circ \gamma)'(t) = \gamma'(t) \neq 0$$ for all $\gamma\in\Frag(X)$ and a.e. $t\in \dom(\gamma)$.

A last key fact for us will be the following result from [@Bate]. Essentially, one would like to know that a phenomenon which happens at almost every


the curves. In contrast to [@Keith Proposition 6], we do not need to adjust $\widetilde{\rho}$ further.

Next, we approximate from below. Let $\widetilde{\rho_n} \nearrow \widetilde{\rho}$ be a sequence of continuous functions with compact support forming an increasing sequence and converging to $\rho$.

As in [@Keith Proposition 6], it suffices to prove that $$\label{eq:limsup}
1 \leq \limsup_{n \to \infty} \inf_{\gamma \in \Gamma} \int_{\gamma} \widetilde{\rho_n}~ds.$$ Indeed, in this case the function $(1-\epsilon)^{-1}\widetilde{\rho}_n$ would be admissible for $\Gamma$ for sufficiently large $n$, forcing $$\Mod_p^c(\Gamma,\mu) \leq (1-\epsilon)^{-p}(\|\rho\|_p^p+\epsilon).$$ Since this holds for all Borel admissible $\rho$ and $\epsilon>0$, the desired inequality immediately follows.

Choose curves $\gamma_n \in \Gamma$ so that $$\liminf_{n \to \infty} \int_{\gamma_n} \widetilde{\rho_n} ~ds \leq \limsup_{n \to \infty} \inf_{\gamma \in \Gamma} \int_{\gamma} \widetilde{\rho_n}~ds.$$

Since $\Gamma$ is compact, there exists a subsequence of $\gamma_n$ which converges inevery $y \in K$,

    (b) $F(x,\cdot)$ is concave and upper semi-continuous on $K$ for every $x \in G$.

Then we have the equality $$\sup_{y \in K} \ \inf_{x \in G} \ F(x,y) \, = \inf_{x \in G} \ \sup_{y \in K}\  F(x,y).$$

Note that, since $\Gamma$ is compact, all curves of $\Gamma$ must lie in a bounded subset of $X$, which must be compact and of finite $\mu$-measure. Thus, it suffices to assume that $X$ is compact and $\mu(X)<\infty$ in the proof.

Let $K$ be the set of Radon probability measures on $\Gamma$. Then $K$ is a compact, convex subset of the space of Radon measures on $\Curv(X)$, equipped with the topology of weak\* convergence. Let $G=\{g \co X \to [0,1]\} \cap C_c(X)$.

Consider the functional $\Phi \co


Thus, the representations $\hat{\cA}_i$ are $(\phi\circ f^{-1})$-independent.

As a consequence, we can now prove Corollary \[cor:bilip\].

Let $X$ be a complete metric space admitting a doubling Radon measure $\mu_0$. Suppose that a measure $\mu\ll\mu_0$ supports $k$ independent Alberti representations, for some $k\geq 1$.

Suppose that $f\colon X \rightarrow {\mathbb{R}}^n$ is a bi-Lipschitz embedding. Let $X'=f(X)$, $\mu'_0= f_{*}(\mu_0)$, and $\mu'=f_{*}(\mu)$.

It follows from Lemma \[lem:ARbilip\] that $\mu'$ admits $k$ independent Alberti representations. Therefore at $\mu'$-a.e. point $x'\in X'$, every tangent $Y'\in{\textnormal{Tan}}_{{\mathbb{R}}^n}(X',x')$ is isometric to $Z\times {\mathbb{R}}^k$, for some closed set $Z\subseteq {\mathbb{R}}^{n-k}$.

The set of all preimages under $f$ of such points $x'\in X'$ forms a set of full $\mu$-measure in $X$. At such a point $x=f^{-1}(x')\in X$, each tangent $(Y,y)\in {\textnormal{Tan}}(X,x)$ is bi-Lipschitz equivalent to an element of ${\textnormal{Tan}}_{{\mathbb{R}}^n}(X',x')$, with a bi-Lipschitz mapand a compact set $K\subseteq Y$ such that $$B(q,c) \subseteq K \subseteq \overline{B}(y, 1)$$ and $$K \text{ is bi-Lipschitz equivalent to } \M.$$

By Corollary \[cor:positivemodulus\], $Y$ is bi-Lipschitz equivalent to $Z\times {\mathbb{R}}$ for some complete (and necessarily doubling) metric space $Z$. As a tangent of $\M$, $Y$ is quasiconvex and therefore so is $Z$.

It follows that $Z$ contains a non-trivial topological arc through each point. Hence, there is a homeomorphic image of $[0,1]^2$ contained in $B(q,c)$. This implies that $B(q,c)\subseteq K$ must have topological dimension $2$. However, this contradicts the fact that $K$ is bi-Lipschitz equivalent to $\M$, which has topological dimension $1$.

Heisenberg group {#subsec:heisenberg}
----------------

Here we give a brief introduction to the Heisenberg group and prove Corollary \[cor:Heisenberg\].

### Preliminaries on the Heisenberg group

We now fix some notation and


(B-b, g(\cdot + b) - g(b)), (A_{\lambda_i, a_i}, f_{\lambda_i, a_i}) \right) \rightarrow 0.$$

Observe that if $q-b\in (B-b) \cap B(0,(2\epsilon_i)^{-1})$, then $q\in B \cap B(0,\epsilon_i^{-1})$ and therefore there is $p\in A$ such that $$|q-\lambda_i^{-1}(p-a)|<\epsilon_i.$$ It follows that $$|(q-b)-\lambda_i^{-1}(p-a_i)| \leq  |q-\lambda_i^{-1}(p-a)| + |b-\lambda_i^{-1}(a_i-a)| < 2\epsilon_i.$$ A similar argument also shows, conversely, that if $\lambda_i^{-1}(p-a_i)$ is an arbitrary point in $\lambda_i^{-1}(A-a_i)\cap B(0,(2\epsilon_i)^{-1})$, then there is a point $q-b\in B-b$ such that $$|(q-b)-\lambda_i^{-1}(p-a_i)|  < 2\epsilon_i.$$ Together, these show that $$d_{(2\epsilon_i)^{-1}}(B-b,  A_{a_i,\lambda_i}) < 2\epsilon_i.$$ By , the functions $g$ and $f_{a, \lambda_i}$ agree up to error $\epsilon_i$ on $(B \cup A_{a,\lambda_i}) \cap B(0,\epsilon_i^{-1})$.

Note that if $q-b\in  (B-b) \cap B(0,(2\epsilon_i)^{-1})$, then $q\in B \cap B(0,\epsilon_i^{-1})$. Similarly, if $\lambda_i^{-1}(p-a_i)\in A_{a_i,\lambda_i}\cap B(0,(2\epsilon_i)^{-1})$, then $\lambda_{i}^{-1}(p-a)\in A_{a,\lambda_i}\cap B(0,\epsilon^{-1}).$

Thus, a basic calculation using and theGolden essays

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    successfully used to construct larger-scale switch fabrics, allowing on-chip integrated optical switch matrices of large size (e.g., 64×64) to be fabricated.
Carrier-effect based phase shifters are susceptible to a self-heating effect caused by electrical power (Joule heating) dissipated mainly in the intrinsic region of a PIN or in the junction region of a PN diode operating under steady-state condition. As a result, a self-heating effect takes place in one of the MZI arms. It increases the operational temperature at this arm and also creates a temperature gradient across the structure. This leads to an additional and unwanted phase shift induced in one arm of the MZI and, in turn, degrading the optical extinction ratio of the switch.
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       strategic partnership Wednesday in which the vendors will jointly build and sell hyper-converged infrastructure appliances, which combine compute, storage and networking on x86 server hardware.

Under the partnership, Lenovo will install Nutanix’s software on its System X servers at the factory, and Lenovo’s direct sales team and channel partners will sell co-branded hyper-converged appliances, Howard Ting, senior vice president of marketing at Nutanix, said in an interview.

Ting said Lenovo and Nutanix won’t be sharing specifics about hardware and configurations until next month.

Another Nutanix partner, who didn’t want to be named, said the Lenovo deal makes some sense considering the ramifications of the Dell-EMC deal.

“It looks like Nutanix may be getting closer to making themselves an OEM play,” said the partner. “After all, that’s what it looks like SimpliVity is


to me that unbalanced maps are usually more fun but having each player with the same resources (like in a skirmish or invasion)is mostly a good idea and will earn you score in reviews.

Creativity: 4

You did put thought into the attractions on this map and the front area with the killing pits made it feel like a hidden fortress as the description says.There could have been more tests and trials for the assassins but I feel that you put sufficient and creative tests to the point where you deserve a 4 :).

Map Design: 3

There wasn't very much in landscaping for this map but the main point is the assassin training exercises anyway so that only kills a 1.0 score to be fair,if you make another map like thisQ:

How to print a parametrized SQL query?

How can I get a String with a parametrized SQL query, once parameters inserted ?

A:

I think you're assuming that the parameter values will be injected into the SQL and that what ends up being sent to the server is a single string. There's no reason why that needs to be the case - although it could be in some cases.
Generally it would make more sense to send the parameters to the database alongside the SQL but distinct from it. That way there's less work for the SQL engine to do (e.g. parsing numeric values which have been convered into strings), less work for the client to do, less risk of SQL injection attacks due to a failure to escape everything perfectly.


The chemical compound nitric oxide is a gas with chemical formula NO. NO is one of the few gaseous signaling molecules known in biological systems, and plays an important role in controlling various biological events. For example, the endothelium uses NO to signal surrounding smooth muscle in the walls of arterioles to relax, resulting in vasodilation and increased blood flow to hypoxic tissues. NO is also involved in regulating smooth muscle proliferation, platelet function, and neurotransmission, and plays a role in host defense. Although NO is highly reactive and has a lifetime of a few seconds, it can both diffuse freely across membranes and bind to many molecular targets. These attributes make NO an ideal signaling molecule capable of controlling biological events between adjacent cells and within cells.
NORes Commun, 284:65-70 (2001)), to regulation of vascular tone, thrombosis, and platelet function (de Belder et al., Cardiovasc Res.; 28(5):691-4 (1994)); (Z. Kaposzta, et al., Circulation; 106(24): 3057-3062, (2002)) as well as host defense (de Jesus-Berrios et al., Curr. Biol., 13:1963-1968 (2003)). Other studies have found that GSNOR protects yeast cells against nitrosative stress both in vitro (Liu et al., 2001) and in vivo (de Jesus-Berrios et al., (2003)).
Collectively, data suggest GSNO as a primary physiological ligand for the enzyme S-nitrosoglutathione reductase (GSNOR), which catabolizes GSNO and consequently reduces available SNO's and NO in biological systems (Liu et al., (2001)), (Liu et al., Cell, 116(4), 617-628 (2004)), and (Que et al., Science, 308 (5728):1618-1621 (2005)). As such, this enzyme plays a central role in regulating local and systemic


as recommended by Dietary Reference Intakes. Median calcium intake for the whole sample was 546.6 mg/day, with 91.30% female and 86.84% male presenting lower than adequate daily recommended ingestion levels (DRI). There was significant difference between calcium densities (Ca mg/1000 kcal) in eutrophic and overweight/obesity in males. Male adolescents showed an inverse relationship between calcium intake and adiposity (r = -0.488 and p = 0.0173), which corroborates the hypothesis that low calcium intake is linked to fatty tissue gain. Only 8.70% of female and 13.16% of male adolescents reached their daily recommended calcium intake levels. It must therefore be stressed that nutritional education is an important protection factor for children and adolescents in later life.71Case Number: SCBD-6847Decided: 11/04/2019THE SUPREME COURT OF THE STATE OF OKLAHOMA
Cite as: 2019 OK 71, __ P.3d __

FOR PUBLICATION IN OBJ ONLY. NOT FOR OFFICIAL PUBLICATION.

State of Oklahoma ex rel. Oklahoma Bar Association, Complainant,
v.
JULIA MARIE EZELL, Respondent.

ORDER OF IMMEDIATE INTERIM SUSPENSION

¶1 The Oklahoma Bar Association (OBA), in compliance with Rules 7.1 and 7.2 of the Rules Governing Disciplinary Proceedings (RGDP), has forwarded to this Court certified copies of the Information and Judgment and Sentence on a plea of guilty, in the matter of State of Oklahoma v. Julia Marie Ezell, CF-2018-3403, in Oklahoma County. On October 16, 2019, Julia Marie Ezell pled guilty to misdemeanor counts of 1) Use of a Computer to Violate Oklahoma Statutes in violation of 21 O.S.2011, § 1958, and 2) False Reports


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Unlike many animal babies, particularly humans, the hatchling Rapetosaurus had adult proportions, meaning it likely did not need significant parental support and was actively foraging for plants rather than waiting for momma to feed it.

Such babies are known as “precocial,” as opposed to “altricial” offspring that have different body dimensions from adults, cannot get around by themselves and require considerable parental support for food and protection, Macalester College paleontologist Kristi Curry Rogers said.

“The main conclusion was that this is the first evidence for a truly precocial dinosaur: one that matured rapidly and without parental care,”the best duo in MLS. Can they both win?

Defender of the Year - Chad Marshall

In his first season with the Sounders, Marshall has been immense in holding down the center of the defense. His presence in the back was felt from the first match of the year (a 1-0 victory of defending champion Sporting KC) and has continued throughout the season. Leading the league in interceptions with 136 and boasting impressive numbers in aerials won (126…#AirMarshall’ing, if you will), clearances (206) and passing accuracy (83%), Marshall has revitalized his career since joining Sounders FC.

Goalkeeper of the Year/Comeback Player of the Year - Stefan Frei

Our Swiss goalkeeper is up for two honors this year, one for his position and a second for his stellar return to prominence after a


of models *in vitro* and *in vivo* \[[@R11]-[@R14]\]. To date, the studies on the cancer-killing activity of celastrol have mainly focused on its ability to induce apoptosis \[[@R15],[@R16]\]. In the present study, in contrast, we show that celastrol kills breast and colon cancer cell lines via inducing paraptosis. Despite recent improvements in anti-cancer therapies, inherent or acquired cellular resistance to various pro-apoptotic treatments often leads to therapeutic failure \[[@R17]\]. Thus, a better understanding of alternative, non-apoptotic cell death pathways, including paraptosis, may facilitate the design of novel therapeutics against malignant cancer cells that harbor defective apoptotic machineries. The term "paraptosis" was originally introduced to describe a form of programmed cell death that is morphologically and biochemically distinct from apoptosis \[[@R18],[@R19]\]. It is characterized by: extensive cytoplasmic vacuolization that\[[@R26]\], although the importance of the respective MAP kinase differs depending on the stimulus \[[@R18],[@R21],[@R22],[@R25],[@R26]\]. We recently showed that proteasomal dysfunction and the generation of mitochondrial superoxide are critical for the curcumin-induced dilation of mitochondria/ER and subsequent paraptotic cell death in breast cancer cells \[[@R21]\]. We propose here that the IP~3~R-mediated release of Ca^2+^ from the ER and its subsequent mitochondrial Ca^2+^ uniporter-mediated influx into mitochondria may critically contribute to extensive dilation of mitochondria and the ER, leading to celastrol-induced paraptotic cell death.

RESULTS {#s2}
=======

Neither apoptosis nor autophagy is critically involved in celastrol-induced cancer cell death {#s2_1}
---------------------------------------------------------------------------------------------

To investigate the anti-cancer effects of celastrol, we treated two breast cancer cell lines (MDA-MB 435S and MCF-7) and two colon cancer cell lines (DLD-1 and RKO) with various doses of celastrol for


extracts were prepared from the treated cells and subjected to Western blotting. β-actin was used as a loading control in Western blots. The fold change of protein levels compared to control (untreated cells) was determined by a densitometric analysis. **(E)** Cells were pretreated with the indicated concentrations of z-VAD-fmk for 30 min and further treated with or without 2 μM celastrol for 24 h. Cellular viability was assessed using calcein-AM and EthD-1.](oncotarget-05-6816-g001){#F1}

When we examined the cellular morphologies following celastrol treatment, we found that marked cellular vacuolation commonly preceded cell death in MDA-MB 435S, MCF-7, DLD-1 and RKO cells (Figure [2A](#F2){ref-type="fig"}). Therefore, we examined whether celastrol-induced vacuolation and subsequent cell death were associated with autophagy. First, we tested the possibility that celastrol induces lysosomal activation, a late step inof SDHA expression and larger rings of PDI expression in MDA-MB 435S cells treated with celastrol for 3 h (Figure [4B](#F4){ref-type="fig"}). A more detailed electron microscopy revealed swollen mitochondria and the ER structures in MDA-MB 435S cells treated with 2 μM celastrol for 3 h. At 6 h of celastrol treatment, fusion among swollen mitochondria and the swollen ER had further progressed (Figure [4C](#F4){ref-type="fig"}). In contrast, untreated MDA-MB 435S cells possessed mitochondria with intact cristae and the ER structures with a reticular morphology. Collectively, these results indicate that celastrol induces paraptotic morphologies. We next sought biochemical evidence for the induction of paraptosis by celastrol. We first tested the effect of the protein synthesis inhibitor, cycloheximide, on celastrol-induced cell death. Pretreatment with cycloheximide (CHX) very effectively blocked cell death


celastrol for 3 h. Immunocytochemistry using anti-SDHA (green) and anti-PDI (red) antibodies was performed and the representative phase contrast and fluorescence microscopic images of cells are shown. **(C)** MDA-MB 435S cells were treated with 2 μM celastrol for the indicated time points and observed by transmission electron microscopy. Arrowheads indicate mitochondria and arrows denote the ER. Swelling and fusion of mitochondria and the ER are seen after celastrol treatment. Bars, 2 μm.](oncotarget-05-6816-g004){#F4}

![Celastrol induces paraptosis\
**(A)** MDA-MB 435S cells were left untreated or were pretreated with cycloheximide (CHX) at the indicated concentrations for 30 min and then treated with 2 μM celastrol for an additional 24 h in the continued presence of CHX. Cellular viability was assessed using calcein-AM and EthD-1. **(B)** YFP-Mito or YFP-ER cells were left untreated orof kaempferol or low-dose (1 μM) celastrol alone, combined treatment with kaempferol and celastrol for 4 h markedly increased \[Ca^2+^\]~m~ and cellular vacuolation in YFP-Mito cells ([Supplementary Figure 3A](#SD1){ref-type="supplementary-material"}). In addition, co-treatment with kaempferol dose-dependently enhanced the death of MDA-MB 435S cells treated with 1 μM celastrol, compared with cells treated with 1 μM celastrol alone ([Supplementary Figure 3B](#SD1){ref-type="supplementary-material"}). Collectively, these observations indicate that MCU-mediated mitochondrial Ca^2+^ uptake may play a critical role in celastrol-induced paraptosis.

![MCU knockdown inhibits celastrol-induced paraptosis\
**(A)** MDA-MB 435S cells were transfected with MCU siRNA and further treated with or without 2 μM celastrol for 24 h. Knockdown of MCU was confirmed by Western blotting using anti-MCU antibody. β-actin was used as a loading control in Western blots (*upper panel*). Cellular viability was assessed using


[9A](#F9){ref-type="fig"}). Staining of YFP-Mito cells with Rhod-2 also showed that 2-APB markedly reduced the celastrol-induced increase in \[Ca^2+^\]~m~ (Figure [9B](#F9){ref-type="fig"}). Furthermore, 2-APB effectively inhibits celastrol-induced dilation of mitochondria and the ER in YFP-Mito and YFP-ER cells, respectively (Figure [9C](#F9){ref-type="fig"}). These results suggest that pretreatment with 2-APB effectively inhibits the celastrol-induced cell death by inhibiting the IP~3~R-mediated release of Ca^2+^ from the ER and the subsequent MCU-mediated influx of Ca^2+^ into mitochondria. In addition, 2-APB pretreatment markedly inhibited celastrol-induced the accumulations of poly-ubiquitinated proteins, CHOP, activated ERK, and activated JNK (Figure [9D](#F9){ref-type="fig"}). The importance of IP~3~R-mediated Ca^2+^ release from the ER in celastrol-induced paraptosis was further tested using adenophostin A, an agonist of IP~3~R \[[@R39]\]. We found that co-treatment of MDA-MB 435S cells with adenophostin A dose-dependently enhanced celland fluorescence microscopy. **(C)** YFP-Mito and YFP-ER cells were pretreated with 20 μM 2-APB, further treated with 2 μM celastrol for 3 h, and observed under the phase contrast and fluorescence microscope. **(D)** MDA-MB 435S cells were pretreated with 20 μM 2-APB and further treated with 2 μM celastrol for 24 h followed by Western blotting. β-actin was used as a loading control in Western blots. The relative phosphorylation levels of the respective MAP kinase were determined by the fold changes of densitometric values in treated groups to the values in the control group. Densitometric values for the phospho-proteins of interest were normalized for protein loading with their total proteins. The relative expression levels of CHOP and ubiquitin were determined using densitometric analysis compared to untreated control. **(E)**


primary subcellular microdomains of Ca^2+^ transfer from the ER to mitochondria \[[@R46]\]. In the present study, following results support the importance of the IP~3~R in celastrol-induced paraptosis: a) pretreatment of MDA-MB 435S cells with 2-APB, an IP~3~R antagonist, inhibited celastrol-induced mitochondrial Ca^2+^ accumulation, mitochondrial and the ER dilation, and cell death; b) co-treatment with adenophostin A potentiated celastrol-induced mitochondrial Ca^2+^ accumulation and cell death; c) celastrol treatment increased IP~3~R protein levels.

Although 2-APB was initially characterized as an antagonist of IP~3~Rs, increasing evidence has shown that 2-APB may be a powerful modifier of store-operated Ca^2+^ entry (SOCE) channels \[[@R51]\]. Low levels of 2-APB (1-10 μM) were shown to rapidly and profoundly stimulate Ca^2+^ entry, whereas higher levels of 2-APB (25-75 μM) induced a transient increase followed by complete inhibitioncoagulation necrosis and intercellular fibrosis. Despite a simple experimental procedure, the present models disclosed myonecrosis with a marked similarity to humans and contained all of the previously reported ultrastructural features of experimental myonecrosis. It is suggested that sustained contraction of smooth-muscle cells beyond their metabolic capability results in the mechanical destruction of myofilaments.


shoot.

But when Republicans target Democrats in less direct fashion, they can be accused of inciting violence. Griffin herself assailed former GOP vice presidential candidate Sarah Palin for releasing a map with targeted congressional districts in crosshairs. When a madman shot and critically wounded Rep. Gabby Giffords, D-Ariz., whose district was in the map, Griffin tweeted, "Happy now Sarah?"

Democratic strategist Maria Cardona saw no need to condemn Griffin. "Frankly I don't think she matters," the CNN contributor wrote in an email. "I think Trump made a mistake in responding to her because it elevated her and her disgusting antic to a level she doesn't deserve. And sure, hypocrisy abounds on both sides. Ted Nugent threatened President Obama's life and Nugent was invited by Trump to the White House."

In 2012,be triaged on the basis of the effect of treatment delays on outcomes. These strategies will be reviewed as the situation evolves.

South Africa is currently at the beginning of a local epidemic. Of particular concern is the large population infected by HIV, which includes approximately 8 million people.[@bib6] While public hospitals prepare for the first wave of COVID-19 patients, oncology services at this point are still aiming to deliver full service when possible, although follow-up outpatient services have been severely curtailed. Subsequently, adjuvant therapy will be reduced when the risk of COVID-19 outweighs the benefit of treatment to decrease avoidable cancer deaths. Primary therapy will continue in ultra-fractioned short courses to curtail treatment delays. Staff will be divided into teams consisting of core personnel.

In Sudan, despite the low


and mounted. Furthermore, assuming that a PGA terminal or the like (typically, a pin-like terminal) is surface mounted on a foot pattern, the problem may happen.
An object of the present invention is to provide a printed circuit board and a semiconductor apparatus which is constructed such that a signal pattern extending from a foot pattern is difficult to break even when a stress is applied to the printed circuit board and a component thereon.
With a view to attaining the above object, the present invention provides a printed circuit board having a plurality of connecting portions for connection to terminals of a component and signal patterns extending from the connecting portions, the connecting portions including outer connecting portions and inner connecting portions, wherein the width of at least aHIV incidence among Black men who have sex with men (BMSM) in the southeastern United States is among the highest in the world. Current trends show that as many as 60% of BMSM will contract HIV by the age of 40 and nearly half (46%) of BMSM who are living with HIV in the US are undiagnosed. Infrequent HIV testing and the poor uptake of evidence-based approaches to preventing HIV by BMSM, particularly HIV pre- exposure prophylaxis (PrEP), constitutes a public health crisis. Among the factors that impede HIV prevention for BMSM, including HIV testing and linkage to PrEP, are the social stigmas and discrimination based on race, sexual orientation and HIV-risk. Furthermore, combinations of stigmas, including race, sexual orientation and HIV-risk intersect to shape unique experiences such


you didn't define what to insert into the column in your insert, it tries to insert null by default and fails.
You must insert something into last name.  I would suggest either a default string or an empty string if you can't get an actual last name to insert.
INSERT INTO sysadm.PS_Z_STAGE_TEST_JE (EMPLID, LAST_NAME)
SELECT DISTINCT(emplid), 'N/A'
FROM ps_vc_plan_mem
WHERE vc_plan_id IN ('PNC-RS','PNC-SO','PNC-ESPP');

Alternatively, you could alter your table so that last_name is nullable.

Iraqis aren’t thrilled with a restaurant being named after a politician that has campaigned to ban Muslims from entering his country, Zawiti defends the President-elect and said that he believes the people of the province will begin to back Trump if he makes good on his word about supporting the Kurds in the fight against ISIS.

“I expect, and I believe, that he will help the Kurds,” Zawiti said, also adding that he plans on expanding the restaurant across the Middle East and hopefully to the United States as well.

The cartoon Trump in the logo was taken from an Uproxx article published in 2015 that depicted every NFL team’s logo rebranded to feature Donald Trump.


hire and discharge the claimant. City of Brunswick v. Taylor, 87 Ga. App. 751, 753 (75 SE2d 203). See Royal Indem. Co. v. Humphries, 90 Ga. App. 567 (83 SE2d 565); State Dept. of Revenue v. McCray, 101 Ga. App. 348 (114 SE2d 64). For "although there is a working arrangement between two corporations or governmental bodies, the one which has the direct supervision and control of the employee is to be considered the master or employer for purposes of compensation." City of Brunswick v. Taylor, 87 Ga. App. 751, 754, supra. Compare State Dept. of Family & Children's Services v. Lassiter, 113 Ga. App. 462 (148 SE2d 453).
3. Here the crucial evidence shows that claimant was hired, supervised, and subject to being discharged by the Hall Countyplants grown in the desert with little water have larger populations of plant growth–promoting (PGB) bacteria which can enhance photosynthesis and biomass synthesis by as much as 40 percent under drought stress. Although PGB’s mechanism of action has not been worked out, the bacteria are known to alleviate salt stress by reducing the production of ethylene in tomato seedlings.

Surprisingly, there is some evidence that the effects of beneficial bacteria can endure across generations. Even after a bacterial community wanes, the biochemical pathways developed by the plants in response to bacterial colonization remain intact. “This suggests the bacteria function as a vaccine of sorts,” says Bais. This heightened disease response can then be passed to the next generation of plants. For example, even when progeny are not exposed to


the degree of genetic dissimilarity between them. Communities with four to six species were better able to ward off invasion. Interestingly, communities were more susceptible to invasion by S. liquefaciens when a lower or higher number of bacterial species was present. Most likely, says Jousset, this is due to the variety of toxins produced. The colonies containing too many species produced a large amount of toxins, some of which also harmed beneficial strains of bacteria, whereas communities with too few species had low levels of toxin production, thus making invasion more likely.

© KNAUPE/ISTOCKPHOTO.COM“This suggests we might be able to encourage disease-fighting bacterial communities by selecting for the right number and combination of species,” says Jousset. Like the gut, the soil is an open system that allows bacteria toQ:

Writing functions inside classes in Python

I'm new to writing classes in Python and had a quick question. Here is some code below.
class Parse_profile():

  def __init__(self, page):
    self.page = page

  def get_title(self):
    list_of_titles = []
    for title in self.page.find_all(.....):
      list_of_titles.append(title.get_text())
    return list_of_titles

  def get_companies(self):
    list_of_companies = []
    for company in self.page.find_all(.....):
      list_of_companies.append(company)
    return list_of_companies

I want to create a third function that will take in both list_of_companies and list_of_titles (and more later on) and combine them into one list.
How do I do that?

A:

def get_companies_and_titles(self):
    return self.get_companies() + self.get_title()

This will


elderly patients can easily recognize any significant changes in their parents' cognitive functions. This may lead to early evaluation and intervention, which contribute to a better cognitive outcome. However, it is plausible that cognitive impairments would have reciprocal relationships with the quality of life, subjective wellbeing, and functional disability in the elderly^[@CR28]^.

Although several important factors that contribute to the predictive model have been briefly discussed, what counts is not the individual risk or protective factors, but a model that encompasses such factors and identifies which one is likely to be cognitively impaired. To date, several research groups, not limited to the Republic of Korea, have used the KLoSA data to examine the risk factors of cognitive impairment. One group evaluated the cognitive changes between 2008 and 2012 anderadicate the engineering paradox of floor degradation in response to the normal model of restricted, single high quality improvement. Tire manufacturers want to maximize general performance of tires. Improvement of such bio-geometry tire properties are the present work of mechanical engineers dedicated to the design and reliability testing of ecologically and safety enhancing tires for both electrical and gasoline fueled automobiles. These developments are capable of transform any automobile, whether they be a Toyota Tacoma or the latest design from Tesla. Alongside the standard quality assurance measures, all joining strategies are topic to course of monitoring, which ensures high quality in each individual stage of production. The MIG (metallic inert fuel) solder seams, as an example, are monitored by means of a 3D gentle-strip sensor. The place, width


steward,’ ‘teacher’. The routinized train of surveillance implies coercion, but overtly includes only the marshaling of data as a way of regulating conduct. The lineaments of the surveillance state have been obvious for a long time, however the explosive advances in computer and communication technologies provide a robust and ever-expanding toolbox of surveillance.

Kettering College is situated in Flint, Michigan and was initially named Common Motors Institute as it was founded by this automotive company. This university is exclusive in that the staff and professors were employed by Normal Motors and worked as engineers within the subject giving this distinctive university has sturdy ties to the automotive world. One distinct advantage that Kettering University college students have over different faculties is a mandatory internship all through the tutorial experience.In effort to fulfill our customer’s calls for for extra perception we added this Guelph automotive detailing blog. We hope you will see the most recent news on the projects and experiences that we encounter to be informative, humorous and addictive. Extra importantly as an economist I can let you know very easily that China’s financial success has nothing to do with no unions and all to do with: successful deliberate economy, the Chinese authorities artificially (and illegally) conserving the foreign money at a low worth to prevent inflation and to help with international trade, Chinese language success additionally is determined by the entire exploitation of the worker.

Without these parts, there would be no water. After all, other elements are crucial. Hydrogen and oxygen on their very own,


range and a 1910 Mercedes Benz Tourabout, which is expected to draw $500,000 to $600,000.

Story continues below advertisement.

Proceeds go to an endowment for the Seal Cove Auto Museum, which Paine founded and which houses his core collection.

Auction catalogs, which admit two people for the auction, cost $50 and are available at the museum. For more details, visit the Web site at www.bonhams.com/paine.    where [skill_name] like '5700 sales l%'
        and [Agent_Time] != '0'
      Group By Cast([start_date] As date), [agent_no]) As C On D.[Date] = C.CallDate
  Left Join (
    select [AC#DTE_dt] As SaleDate, [EMPJDENUM], Count(*) As Sales
      from sales_table
      where [ICGCD2] in ('LAWN', 'HORT')
        and [CHANNEL]= 'INQ'
        and [ITMQTY]>3
      Group By [AC#DTE_dt], [EMPJDENUM]) As S on D.[Date] = s.SaleDate
  right join Employee_table As E
    on C.[agent_no]=E.agent_no
    and S.[EMPJDENUM]=E.emp_jde;

Edit
In order to get a row for


and then realize I’m out of my depth – so over to YouTube or Instructables I go.

Once the project is done, I now not only have the thing I’ve built, but I also have a bunch of new skills and knowledge – how to properly apply epoxy, for example.

That’s why I think it’s an excellent idea to get your hands dirty and go the DIY route from time to time when you need to solve a problem. You gain new skills, get the satisfaction of doing it yourself – and (sometimes) you save money to boot.

But where do you go to learn DIY? Well, as a mentioned before, one of my favorite haunts is YouTube. And on of my favorite DIY YouTube channels is I Like to MakeYou can quickly add items to the Finder Dock or Sidebar with this easy keyboard trick. Although Apple probably meant for it to be primarily used for folders, it actually works on a variety of different file types.


Renal transplantation in systemic lupus erythematosus.
3 patients with chronic renal failure due to lupus nephritis received kidney allografts from cadaver donors. Serological activity was present in 2 patients at the time of transplantation, and continued unabated despite intensive immunosuppressive therapy. Their allograft failed at 5 and 7 months after transplantation. Anti-DNA antibody in the allograft was found in 1 patient. The 3rd patient, with no serological activity at the time of transplantation, remained serologically negative, and her allograft functioned for 18 months. The persistence of serological activity in 1 patient, and the recovery of anti-DNA antibody from her allograft provide proof for the recurrence of lupus nephritis in the allograft.of knowing the standardized effect size, so that aducanumab can be compared with other interventions.

Overall, most researchers cautiously agreed that what they can see so far of the new analysis appears sound, and that the futility analysis was likely wrong. “This is not the first time I’ve seen a company get burned by futility analysis,” said Marwan Sabbagh, who leads the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas. Roche’s gantenerumab failed futility analysis in the Phase 3 SCarlet RoAD trial (Dec 2014 news). That nearly derailed the program, before a deeper data analysis indicated that differences between fast and slow progressors in the trial might have masked a possible treatment benefit among a subgroup of participants with the highest exposure (Nov 2015 news). “We


Minnie Minoso play, I always thought I was looking at a Hall of Fame player," Reinsdorf said in an informational package produced by the team for a 2011 Cooperstown push. "I never understood why Minnie wasn't elected.

"He did everything. He could run, he could field, he could hit with power, he could bunt and steal bases. He was one of the most exciting players I have ever seen."

Saturnino Orestes Armas Minoso Arrieta was selected for nine All-Star games and won three Gold Gloves in left. He was hit by a pitch 192 times, ninth on baseball's career list, and finished in the top four in AL MVP voting four times.

Despite the push by the White Sox and other prominent Latin players, Minoso has never made it to Cooperstown.was one of them," Hall of Fame slugger Tony Perez said. "The way he played the game, hard all the time, hard. He was very consistent playing the game. He tried to win every game. And if you want to be like somebody, and I picked Minnie, you have to be consistent."

Minoso appeared in just nine games in his first stint with the Indians, but he took off when he was dealt to Chicago as part of a three-team trade in 1951 that also involved the Philadelphia Athletics. He went deep in his first plate appearance against Yankees right-hander Raschi, and hit .375 in his first 45 games with the White Sox.

Minoso finished that first season in Chicago with a .326 batting average, 10 homers and 76 RBIs


violating it one year and keeping it sacred another, that they may agree in the number (of months) that Allah has made sacred, and thus violate what Allah has made sacred; the evil of their doings is made fairseeming to them; and Allah does not guide the unbelieving people. (9:37)

And apparently this was so important (unlike abolishing slavery) that he mentioned it in his final sermon. Prophet Muhammad said:

Time has completed a cycle and assumed the form of the day when Allah created the heavens and the earth. The year contains twelve months of which four are sacred, three of them consecutive, viz. Dhul-Qa’dah, Dhul-Hijjah and Muharram and also Rajab of Mudar which comes between Jumadah and Sha’ban.

The solar calendar is off by about 10 days, causing theis established between the two levels of the clock transition and a cavity (the main cavity) is employed to provide weak optical feedback to the stimulated emission of active optical clock. The linewidth of the main cavity mode of active optical clock is designed to be much wider than the gain profile of clock transition, and the frequency of the stimulated emission will thus be insensitive to the main cavity-length noise.

Currently the 1470 nm lasing of Cs four-level active optical clock has been realized [@Xu; @Xu2; @Pan]. The cavity pulling effect is measured to be reduced by a factor of about 40 [@Xu; @Pan] and a linewidth of sub-kHz is observed. However, the main cavity length of Cs active optical clock is still not stabilized.

In this paper, the dual-wavelength active


of about 25 [@Xu2]. The 1359 nm output frequency stability of the dual-wavelength active optical clock is then expected to be further improved by at least 1 order of magnitude than the 633 nm PDH system

The main cavity length of the 633 nm and 1359 nm good-bad cavity dual-wavelength active optical clock is designed to be $L=15 $ cm. The length of the Cs cell in the main cavity is $L_{cell}=5 $ cm while the length of the specially designed He-Ne laser element is about 10 cm. The free spectral range (FSR) of the main cavity is $FSR=\frac{c}{2L}=1 $ GHz. The 633 nm gain bandwidth is chosen to be 1.5 GHz, the same as in traditional 633 nm He-Ne lasers. The reflectivity of the main cavity output mirror (M3main cavity at 1359 nm is theoretically calculated to be $F_{1359}=\pi\frac{\sqrt{R_{1359}{T_{1359}}^2}}{1- R_{1359}{T_{1359}}^2}=4.6$. The 1359 nm linewidth of the main cavity mode is then $\Gamma_{c1359}=\frac{FSR}{F_{1359}}=217.39 $ MHz. The factor $a=\frac{\Gamma_{c1359}}{\Gamma_{g1359}}=24.5$ and the cavity pulling effect of 1359 nm output is expected to be reduced by a factor of 25.5 according to our previous experimental results [@Xu2]. The 1359 nm output working in the bad-cavity regime is used as the final optical frequency standard of the 633 nm and 1359 nm good-bad cavity dual-wavelength active optical clock and the frequency stability of the 1359 nm output can be improved by at least 1 order of magnitude than 633 nm PDH system.

Quantum limited linewidth of 633 nm and 1359 nm good-bad cavity dual-wavelength active optical clock
=====================================================================================================

An estimate of the quantum limited


- 1
Let d(y) = -20*y - 16. Let x(o) = -4*o - 3. Give -3*d(p) + 14*x(p).
4*p + 6
Let a(y) = 9*y**2 + 2*y - 2. Let w(j) = -19*j**2 - 5*j + 5. Calculate -5*a(i) - 2*w(i).
-7*i**2
Let y be (5/2)/(25/60). Let j(g) = -8*g + 8. Let c(n) = 7*n - 7. Calculate y*j(k) + 7*c(k).
k - 1
Let w(n) = n**2 - 2*n - 2. Let u(z) = -1. What is -2*u(d) + w(d)?
d**2 - 2*d
Let o(b) = 6*b**2 - 3*b + 8. Let y = 21 - 16. Let t(f) = -4*f**2 + 2*f - 5. What is y*o(z) + 8*t(z)?
-2*z**2 + z
Let y(j) = -4*j**2 + 4. Let b(w) = -8*w**2 + 17*w + 8. Let h(m) = -m**2 + 2*m + 1. Let f(i)order and

waiver of hearing in which he acknowledged receiving notice of his rights but waived

representation and a hearing. He admitted the factual basis for removal and agreed to

accept a written removal order. The document was read to him in Spanish by a Border

Patrol Agent who attested that Rivera-Lopez’s signature was voluntary, knowing, and

intelligent. In May 2004, he was found subject to removal based on these stipulations and

was ordered removed. Rivera-Lopez waived his right to appeal the decision and was

removed shortly thereafter. In light of these facts, we conclude that Rivera-Lopez cannot

meet the requirements of § 1326(d).

      We accordingly affirm the district court’s judgment.       We dispense with oral

argument because the facts and legal contentions are adequately presented in


product as it can be used as a cleaner too. I sprayed both of the pushchairs, the Cosatto wasn't dirty as its fairly new but it was nice to spray it so I know the germs are almost gone, I did use the cleaning method on the iCandy though as when I looked at it I was surprised at how dirty it was. Im so use to putting the kids in and not really looking at the seats, the marks did come off the seat which was good, I just need to hoover them out now as the amount of crumbs etc in the creases is disgusting! Im definitely going to make a habit of spraying the seats often with this spray, especially in the winter.

Here is a5*p + 5. Let q be (-2 - -2) + (-18)/(-3). Let s(c) = 10*c**2 - 6*c - 6. Let t(j) = q*k(j) + 5*s(j). Determine t(h(w)).
-36*w**2
Let h(s) = -5*s. Suppose -4*a = -w - 17, -5*w - 3*a - a = -35. Let y(r) =


Aloha Festivals Honors Hawaiian Culture

Looking for something to do to celebrate the start of fall? Why not attend Oahu’s Aloha Festivals?

Established in 1946, the Aloha Festivals is the largest Hawaiian cultural celebration of Hawai‘i’s music, dance and history—intended to showcase our unique traditions.

Here are some highlights:

Aloha Festivals 2014 Royal Court Investiture & Opening CeremonySaturday, September 6th – Royal Hawaiian Center, Royal Grove
The king, queen, prince and princess take their place in the royal court at this official kick-off of Aloha Festivals events.

62nd Annual Aloha Festivals Waikīkī Ho‘olaule‘a
Saturday, September 20th – Kalākaua Avenue
The annual Waikīkī Ho‘olaule‘a is Hawai‘i’s largest block party. Thousands of people crowd the streets along Kalākaua to enjoy Hawaiian music and hula performances, crafts, and the many different types of island cuisine.committee holding cross-country hearings into the future of the public broadcaster. "They can't get ratings. So if they can't get ratings, they can't get revenue. They eat up the budget they're getting from taxpayers, and that budget, in my view, is there to promote Canadian content."

Tory Senator Donald Plett questioned whether the CBC even needs foreign correspondents: "We have a situation in Africa with the Ebola crisis and we have a situation in the Middle East with ISIL. All the major networks are there. Is it necessary for the CBC to be there? Quite frankly, if I want to know what's happening in Syria, I can go to CTV or Global and find out."

The Conservatives are hardly novel in detecting an unfavourable bias in the CBC's news coverage.


to violence and insurgency today than it had been before. On July 1, as many as 64 soldiers were killed in coordinated attacks by Egypt’s Islamic State affiliate, which calls itself the Province of Sinai. It was the worst death toll in decades, and came just days after the country’s chief prosecutor, Hisham Barakat, was assassinated.

If this is what a “stability-first” approach looks like, Egypt’s future is dark indeed. Of course, it shouldn’t be surprising that the country is growing less secure: Since the overthrow of the Muslim Brotherhood’s Mohamed Morsi on July 3, 2013, Egypt has seen shocking levels of repression. On Aug. 14, 2013, it witnessed the worst mass killing in its modern history, with at least 800 killed in mere hours when security forces violentlydispersed two pro-Morsi sit-ins in Cairo. WikiThawra, a project of the Egyptian Center for Economic and Social Rights, estimates that nearly 36,500 people were arrested or detained from the day of the coup through May 15, 2014 — one can only imagine how high that figure has grown a year later.

Since April 2015, meanwhile, at least 163 Egyptians have “disappeared.” As one prisoner recalled of his time at Azouli, a military jail which can’t be seen by civilians: “There is no documentation that says you are there. If you die at Azouli, no one would know.”

This repression, which targets not just Islamists but also secular and liberal opposition activists, makes the resort to violence and terror more likely among at least some Egyptians. There is a growing trend


has articulated a policy toward Christian minorities based on a 7th-century pact, an approach to Islamic economic jurisprudence, and even a theory of international relations.

The Islamic State’s unlikely successes in governance undermine a key premise of mainstream Islamists — that because of their gradualism, pragmatism, and “competence,” they, rather than extremists, are better suited to delivering on bread-and-butter issues. In fact, the opposite appeared to be true: Brotherhood-style gradualism and a willingness to work through the democratic process hadn’t worked. One senior Brotherhood official told me, as we sat in a café on the outskirts of Istanbul, “If I look at the list of mistakes the Brotherhood made, this is the biggest one: trying to fix the system from inside gradually.”

Even those who otherwise abhor the Islamic State’sPresident Donald Trump says he won’t be played like his predecessors when it comes to North Korea.

‘This isn’t like past administrations. We don’t play games,’ Trump said.

The president said he doesn’t believe that North Korea’s dictator is playing him, anyway.

‘I don’t think he’s playing, no. I don’t think he’s playing,’ Trump told a reporter in the Oval Office. ‘It’s never gone like this. It’s never gone this far. I don’t think it’s ever had this enthusiasm for them wanting to make a deal.’

Trump wouldn’t say at a news conference whether he had personally spoken to Kim. ‘I don’t want to comment on that,’ he asserted. ‘But we have a very good working relationship.’

He said that he does feel a personal responsibility to broker a deal with Kim, if


Integrated class D audio amplifiers have been around for more than 10 years and steadily gained popularity due to numerous advantageous characteristics such as high power conversion efficiency, small dimensions, low heat generation and good sound quality. Bipolar CMOS and DMOS high voltage semiconductor processes are typical candidates for implementation of these integrated class D audio amplifiers which feature large LDMOS devices as active switches of output stages. These LDMOS transistors are isolated high side devices and typically of NMOS type to minimize transistor dimensions for a given output resistance. As the bipolar CMOS and DMOS high voltage semiconductor processes continue to evolve to feature sizes at 180 nm and below, the gate drive voltage required to the LDMOS active switches is approaching a voltage level around 5have been introduced lately in the literature to represent the preferences in a compact way. They rely on the notion of (conditional) preferential independency among attributes and can be described in terms of vertices and edges of a graph [@amor2016graphical]. In what follows, we review the basic methods used to represent preferences (interested readers can refer to [@fishburn1970utility] for a comprehensive introduction to the field). Informally, preferences are any additional knowledge that is not part of the problem requirements and objectives, but represent the subjective judgments of the users in terms of liking or disliking an alternative.

child [node\[style2\] (c1) [Qualitative]{}]{} child [node\[style2\] (c2) [Graphical Models]{}]{} child [node\[style2\] (c3) [Quantitative]{}]{}; (c11) [Binary relation]{}; (c12) [Lexicographic]{}; (c21) [GAI-nets]{}; (c22) [CP-nets]{}; (c31) [Utility function]{}; (c32) [Weights]{}; (c33) [Soft constraints]{}; in [1,2]{}


$ is said to be complete iff $x\succeq x'$ or $x'\succeq x$ for any $x,x'\in S$.

A complete partial order is also known as a linear order or a ranking over a set $S$. In such case, any two alternatives are comparable and one is preferred to the other. Lexicographic preference relations are also common in practice where an importance order over attributes are assumed.

Another model of preferences that has gained much attention in recent years is the soft constraint model. In such model, constraints are associated with numerical values representing the cost, importance, or preference and unlike hard constraints, alternatives are not required to satisfy all of them. A formal representation for soft constraints is Valued Constraint Satisfaction Problem (VCSP) [@schiex1995valued]. Lastly, the concept of reference point isto be placed close to each other.

-   Flexible split preferences [*i.e.,* ]{}allow group VMs to be placed on different clouds or in the same cloud.

\
Anti-colocation & [@Chen2017; @Dow2016; @Georgiou2013] &

-   Place VMs disjointly for security, reliability, or administrative purposes.

\
Sharability & [@Mahalingam2015; @SunilRao2015] &

-   A customer prefers to not share a PM with others.

\
Migration cost/overhead & [@Kella2014; @LiWeiLing2017; @Xu2011; @Zhou2013] &

-   VMs with lower migration overhead are more preferred to migrate.

-   VMs with migration cost ([*e.g.,* ]{}susceptible to SLA violation due to migration) are less preferred to migrate.

\
Availability/ Reliability & [@Zhou2013; @Araujo2018] &

-   Include the degree of PM wear-and-tear ([*e.g.,* ]{}due to frequent PM ON/OFF cycles) in weighted function.

-   Replicate a VM to improve its


which PM to be placed and used a variant of NSGA-II to return preferred solutions based on the notion of ceteris paribus preferences.

### Simulated Annealing

Another common technique to solve the VMP problem is Simulated Annealing, a single-based metaheuristic technique to solve optimization problems [@johnson1989optimization]. A number of proposals have developed simulated annealing-based heuristics to solve the VMP problem. @Tsakalozos2011 developed a two-phase VM-to-PM placement scheme in which a group of PMs, termed cohort, are first identified as potential host based on some properties, then the final constrained mapping is resolved taking into account customers’ special requirements and preferences. The goal of selecting a subset of all available PMs in the first phase is to reduce the number of constraints and the search space during the second phase. In[@Li2016], a descriptive language based on XML for the preferences of data center managers was proposed. The goal is to automate the matching procedure while classifying preferences into two classes; namely, flexible and inflexible. @Wangj2016 addressed the problem when VMs and PMs cooperate on a mutual objective (reducing the overall energy consumption). @Chu2017 added storage PMs as a third set into the matching where storage PMs prefer smaller VMs. @Pillai2016 considered the case where IaaS request is beyond the capability of a single PM and therefore developed a mechanism to form coalition with the goal of minimizing the total execution time based on uncertainty principle in game theory. The work in [@ZhangY2017] addressed the problem of migrating VMs for security preferences to make it harder for attackers to


preferential colocation and anti-colocation. Alternatively, @Georgiou2013 developed an Opportunistic-Fit algorithm addressing the problem of placing VMs with an Infrasturctue-as-a-service (IaaS) request, in which a group of VMs are jointly consolidated in the cloud. Considering DC PortLand architecture, they proposed two VM placement algorithms that exploit users’ hints about the desired features of the requested IaaS. Users specify their requirements on the VMs and their colocation preferences through an XML document. The hints considered here are concerned with the bandwidth needs for specific pairs of VMs and the anti-colocation constraints for pairs of VMs. In the first algorithm, a greedy algorithm places requested VMs as close as possible to each other while satisfying colocation requirements as much as possible; otherwise, a path with sufficient bandwidth is established between them.other physical entities so that an objective function is optimized. The algorithm takes into account both administrators’ and users’ requirements and allows users to specify their preferences over the constraints (hard/soft constraints) over some criteria such as location. The biasing pushes the solution towards satisfying constraints and preferences. @Unuvar2014 adopted the same method to address VMP in hybrid clouds. The placement decision takes into account whether private or public cloud is preferred for a customer and a customer preference on splitting VMs over private and public clouds. @Sotiriadis2016 presented VMs migration within OpenStack cloud platforms considering the FIWARE platform [^2]. The migration tool is developed following the FI-WARE conceptual model and offers a set of software modules, called Specific Enablers (SEs), that allow flexible development of healthcare applications.


having the preferences upfront, it is better to elicit them during the solving process. Such elicitation holds the promise of proposing interactive learning strategies that consider humans in the loop when solving the VMP; thus, lowering the cognitive burden in specifying preferences. Another approach is to learn customers’ and administrators’ preferences from historical data ([*i.e.,* ]{}learning preferences passively from past deployments).

Group Decision Making

:   The VMP problem is inherently a group decision making problem. A group of customers and cloud administrators issue their preferences on different aspects of the problem. It is likely that the issued preferences are conflicting with each other and further aggregation and reconciliation methods are required. For instance, consider the scenario of @Ilkhechi2015 where each group of VMs relies heavily on some PMstimes close to deceitful, behaviour by the senior officers in South Yorkshire sounds depressingly familiar.” He then concludes that “Liverpool fans – who have caused trouble in the past – will feel vindicated.”

Despite this, it is now known that Mrs Thatcher chose to respond by noting “What do we mean by ‘welcoming the broad thrust of the report’? The broad thrust is devastating criticism of the police. Is that for us to welcome? Surely we welcome the thoroughness of the report and its recommendations.” Mrs Thatcher’s trusted and loyal chief press spokesman for 11 years, Mr Bernard Ingham, expressed the very clear view that “there would have been no Hillsborough disaster if tanked-up yobs had not turned up in very large numbers to try to force their way


reason why many, many survivors are still with us today is “not in spite of the fans and their actions; it is because of them – and we Conservatives should say so clearly today.”

It is now one year since I first wrote to you on this matter on 5th March 2013 (copy attached). This is now my tenth letter. Some of these letters have been totally ignored. Some have received brief dismissive responses. Some have been forwarded to various departments (always claiming to be ‘best placed to answer the question’) who then simply provided information as a way to avoid answering my very simple question.

It is a very simple question. Mr Cameron, do you agree that the actions of the ordinary men and women at Hillsborough on 15thSynthesis of quinolactacide via an acyl migration reaction and dehydrogenation with manganese dioxide, and its insecticidal activities.
Quinolactacide isolated from Penicillium citrinum F 1539 was synthesized and evaluated for its insecticidal activities. The key steps of the total synthesis were an acyl migration reaction of the enol ester intermediate and dehydrogenation of tetrahydroquinolactacide with manganese dioxide. The synthesized quinolactacide showed 100% and 42% mortality against the green peach aphid (Myzus persicae) and diamondback moth (Plutella xylostella) at 500 ppm, respectively.


(с++) я собираюсь передать данные в uniform параметры шейдера. Сразу отмечу - компиляция шейдера успешна а конвеер коректен. Естественно перед передачей данных нам нужны позиции uniform. Вот тут и проблема. Как делаю я

//...
m_WVPLocation         = GetUniformLocation ( "gWVP" );
  m_WorldMatrixLocation = GetUniformLocation ( "gWorld" );
  m_samplerLocation     = GetUniformLocation ( "gSampler" );
m_dirLightLocation.color            =   GetUniformLocation ( "gDirectionalLight.base.color" );
  m_dirLightLocation.ambientIntensity =   GetUniformLocation ( "gDirectionalLight.base.ambientIntensity" );
  m_dirLightLocation.diffuseIntensity =   GetUniformLocation ( "gDirectionalLight.base.diffuseIntensity" );
  m_dirLightLocation.direction        =   GetUniformLocation ( "gDirectionalLight.direction" );
m_eyeWorldPosLocation           = GetUniformLocationbasic idea behind any solution will be the same: save a copy of the original data from before editing so you can revert to it upon canceling.
Here are two good ways to do that:

Use a library, e.g. ko.editables is designed for exactly this purpose.
Do It Yourself. It's actually not that hard: you save the model behind the view model upon initialization, and upon "save", and reuse the initialize method on "cancel".

Here's some sample code for the latter:

var dummyItem = { id: 42, name: "John doe" };

function ItemViewModel(data) {
  var self = this, currentDto = data;

  self.id = ko.observable();
  self.name = ko.observable();

  self.isInEditMode = ko.observable(false);

  self.reset = function() {
    self.id(currentDto.id);
    self.name(currentDto.name);


anaesthetised at the scene and taken to hospital. Another passenger, a man in his 50s, and the male driver suffered minor injuries in the accident which happened at about 6pm on the A45, between Stretton-on-Dunsmore and Rugby, in Warwickshire.while another will let you carry 25. You need to weigh the pros and cons to see what you can live with and what you can live without. You can also buy some time saver packs using real world money like you could in Black Flag if you so choose but it isn’t required. The way these work is you have to use helix credits to purchase the Murder Mystery map, for example, and you can buy these by purchasing a Helix Credit Pack. The minimum you can spend is $10 and you can go up to $99.99 but it is by no means a requirement. You can still do everything with the original $60 you spent on Assassin’s Creed Unity. These are just time saver packs but


job to be able to build multiple binaries).
Auto build (This job parses the change set in the repository and calls the build multiple binaries, with the apps to build. Reason for this, is if a SCM change occurs, I don't want to build all apps again in the repository. I want to only build the apps that changed.)

What I want to do:
I want the Build 1 binary to send email notifications of the change set, just for that app that got built.
Example Email:
Subject: App1 Successful build
Changes: App1/app1.source, App1/app1.properties

The problem is because Auto build picks up the change set from the GIT change, I don't have a way right now to find the change set in the build job. What I am thinking is parsing the changewent over to a friend's friend's house for his birthday party. For some reason the guy had never liked me, but whatever. I spent the first half of the night in the basement with his girlfriend, who was terribly distraught because she felt the need to break up with him, but certainly couldn't do such a thing on his birthday. I gave her sound counsel, and went back upstairs to the party where the birthday boy promptly declared he could whup anybody's ass in Killer Instinct.

"Excuse me?" I said. "I'll bet you that king sized pack of Pez candy on your kitchen counter that you couldn't beat me. Sabrewulf, baby!"

"Sabrewulf is slow as shit - you're on!"

The best thing about Killer Instinct is how you can beat the


a vector space.. We are looking at a collection of vector spaces..
Dimension of each of these vector spaces is related to the order of the group (in the case of finite groups)..
To each irreducible representation we have a vector space associated with it. Suppose $V_i$ is vector space related to irreducible representation $\eta_i$ for $1\leq i\leq r$ we then have
$$|G|=n_1^2+n_2^2+\cdots+n_r^2$$
where $n_i$ is the dimension of vector space $V_i$..

U.S. is lagging behind several other countries in academics, and coupled with the fact that only 18% of U.S. high school students can pass a science proficiency test it is clear that something must be done to address what will be a drastic shortage of scientists in our country.

Finding solutions for building an effective workforce of scientists who can solve our most difficult technological challenges by inspiring U.S. students to purse science careers. These solutions included public policy solutions, alignment of academic standards, federal funding, curriculum innovation and educator training.

"Amgen is proud to be a part of today's important dialogue," said Joe Miletich, senior vice president of Research and Development at Amgen. "Amgen, and other companies on the cutting edge of biotechnology, depend on the ingenuity and pioneering


in the fight against cancer, kidney disease, rheumatoid arthritis, and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and our vital medicines, visit www.amgen.com.

(Date:12/7/2016)... Diego (PRWEB) , ... December 07, 2016 , ... ... data from its phase I/II dose escalation and expansion clinical trial for its ... in Vienna, Austria. The purpose of the trial was to determine the safety, ...

(Date:12/7/2016)... , Dec. 7, 2016 Neogen Corporation ... named Dr. Dan Kephart as its chief ... Kephart will assume his responsibilities at Neogen effective Jan. ... development director for the agribusiness unit of Thermo Fisher ... development at Life Technologies. His extensive industry experience2017, Spanish Government and Catalan regional government. Serrat holds the view that the 2017 unilateral Catalan Nationalist push for secession and the reaction from the government of Mariano Rajoy served the purpose of "covering up years of cuts and economic corruption" from both the Catalan regional government and Spanish national government. He has been the target of boycotts and abuse from sections of the Catalan independence movement because of his political views..

Select discography

Albums
 1967: Ara que tinc Vint Anys
 1968: Cançons Tradicionals
 1969: Com ho fa el Vent
 1969: La Paloma
 1969: Dedicado a Antonio Machado, poeta
 1970: Serrat IV
 1971: Mediterráneo
 1972: Vagabundear
 1972: Miguel Hernández
 1973: Per al meu Amic
 1974: Canción Infantil
 1975: ...Para Piel de Manzana
 1976: Retratos
 1977: Res no és Mesquí
 1978:


Beyond these applications, wide-field multispectral and fluorescence imaging can be valuable for clinical applications such as characterizing the structure and function of a broad range of tissues including cervix, retina, oral mucosa, gastric tissues, the heart, internal organs during surgery and skin \[[@r4]--[@r9]\], and for basic research applications such as small animal molecular imaging \[[@r10]--[@r12]\].

Despite the simplicity of camera-based optical imaging, commercial in-vivo imaging systems are restricted in their utility for more than their specifically designed application, and typically cost in excess of \$100,000. While researchers can purchase their own cameras and construct their own imaging systems, commercially available cameras are typically available with either user-oriented software packages optimized for in-vitro microscopy (e.g. point-and-click single frame acquisition, or slow time-lapse image acquisition routines), or manufacturers provide only softwaredevelopment kits (SDKs) that leave the user to construct their own control software.

For in-vivo imaging studies, a camera-based system requires a number of design parameters that differ from those characteristic of microscopy-oriented systems, specifically:

1.  The ability to acquire 'runs', or 'sets', of data at high frame rates for periods of between 10 and 60 seconds. The start of each run must usually be triggered either internally by the camera or externally via an outside trigger timed precisely to stimulus or other experimental events.

2.  The ability to acquire multiple 'runs' of data in sequence without additional user input.

3.  The option to save acquired images in a standard image format, suitable for analysis by custom or commercial software analysis packages.

4.  A simple graphical user interface (GUI)


pre-determined number of images to the camera control computer's hard disk (see Section 3.3 for a discussion on the 'Movie' acquisition routine). 'Preview' displays real-time, sample movie data which is not saved to disk, can be analyzed in real-time, and is typically used during alignment procedures. Multispectral illumination can be provided during both 'Movie' and 'Preview' acquisitions. Acquired images are displayed in their own pop-up windows, separate from the control GUI.

2.  The available camera attributes can be controlled from the diagnostic panel. SPLASSH automatically detects and enumerates all of the available attributes in this panel such as Brightness and Gain during system start up.

3.  The desired shutter speed of the camera can be input in units of either frame rate or exposure time. The other attributethe microcontroller to use a preprogrammed strobe sequence. If the process is successful, the user is allowed to begin image acquisition. During acquisition the microcontroller is driven by the camera to turn the LEDs on/off. A frame counter provides the next LED in the sequence. When acquisition ends, the microcontroller is reset.. The process begins when a user selects a preprogrammed illumination pattern from the GUI. If an invalid sequence has been selected, no illumination is set and the user must start again (error path in [Fig. 4](#g004){ref-type="fig"}). If an acceptable order is input, the sequence is passed to the microcontroller via the USB RS-232 bus, and the microcontroller analyzes the information to determine how it will loop through the light sources in the desired order. Themicrocontroller then


the private party such that the state can be held responsible for the private party's decision; or (2) delegates a public function to a private entity." Johnson v. LaRabida Children's Hosp., 372 F.3d 894, 896 (7th Cir.2004) (internal citations and quotations omitted). The public function test examines whether the state has delegated to the private entity a function which is "exclusively reserved" to the State. Cornish v. Corr. Servs. Corp., 402 F.3d 545, 550 (5th Cir. 2005). This is a "rigorous standard that is rarely satisfied." Leshko v. Servis, 423 F.3d 337, 347 (3d Cir.2005) (internal quotations and citations omitted). To determine whether the State effectively directs or controls the actions of the private party, the Court examines whether the State exerts such coercive power over the privateF.3d at 347 (same); Holly v. Scott, 434 F.3d 287, 293 (4th Cir.2006) (reversing denial of motion to dismiss, remanding, and ordering dismissal where plaintiff did not make showing that defendants were state actors); Cranley v. Nat'l Life Ins. Co. of Vermont, 318 F.3d 105, 113 (2d Cir.2003) (affirming dismissal of Section 1983 claims because plaintiff did not make showing that defendants were state actors); Single Moms, Inc. v. Montana Power Co., 331 F.3d 743, 749 (9th Cir.2003) (same). In fact, in a case discussed further below, the Seventh Circuit affirmed the dismissal of Section 1983 claims against the ABA and other bar associations because they were found not to be state actors. See Lawline v. Am. Bar Ass'n, 956 F.2d 1378 (7th Cir.1992).

A. Section 1983 Claims Against


Q:

Send parameter on Button Click . (ASP . net C#)

I have an asp button, and I want to send parameter to codebehind when it's click.
so I do like this tutorial:
http://www.devchix.com/2007/08/10/aspnet-passing-parameters-in-button-click-handler/
I have button:
            <asp:Button ID="button1" runat="server" CommandArgument="MyVal1"
   CommandName="ThisBtnClick" OnClick="MyBtnHandler" />

and event :
  void MyBtnHandler(Object sender, EventArgs e)
        {
            Button btn = (Button)sender;
            switch (btn.CommandName)
            {
                case "ThisBtnClick":
  }{C}\overset{}{_{bc}^{a}},\underset{\left(
i2\right) }{C}\overset{}{_{bc}^{a}}\right) ,$$\left( i=0,1,2\right) .$

In this paper we get the Ricci identities for the Liouville d-vector fields $z^{\left( 1\right) \alpha }$ and $z^{\left( 2\right) \alpha }$ (Theorem 5.2). The same problem was solved by prof. Atanasiu Gh. in [@at] for the Liouville d-vector fields $z^{\left( 1\right) a}$ and $z^{\left( 2\right)
a}. $

The 2-osculator bundle $\left( Osc^{2}M,\protect\pi ^{2},M\right) $
===================================================================

Let M be a real differentiable manifold of dimension n. A point of M will be denoted by x and its local coordinate system by $\left( U,\varphi \right)
,\varphi \left( x\right) =\left( x^{a}\right) .$ The indices $a,b,...$run over set {1,2,...,n} and Einstein convention of summarizing is adopted all over this work.

Let us consider two curves $\rho ,\sigma :I\rightarrow M$, $\ $having images in a domain of local chart $U\subset M.$ We say that


a point of $Osc^{2}\check{M}$ by the rule:$$\begin{array}{l}
dx^{a}=\dfrac{\partial x^{a}}{\partial u^{\alpha }}du^{\alpha } \\
\\
dy^{\left( 1\right) a}=\dfrac{\partial y^{\left( 1\right) a}}{\partial
u^{\alpha }}du^{\alpha }+\dfrac{\partial y^{\left( 1\right) a}}{\partial
v^{\left( 1\right) \alpha }}dv^{\left( 1\right) \alpha } \\
\\
dy^{\left( 2\right) a}=\dfrac{\partial y^{\left( 2\right) a}}{\partial
u^{\alpha }}du^{\alpha }+\dfrac{\partial y^{\left( 2\right) a}}{\partial
v^{\left( 1\right) \alpha }}dv^{\left( 1\right) \alpha }+\dfrac{\partial
y^{\left( 2\right) a}}{\partial v^{\left( 2\right) \alpha }}dv^{\left(
2\right) \alpha }\end{array}
\tag{2.4}  \label{2.6}$$We used the previous theory for study the induced geometrical object fields from $Osc^{2}M$ to $Osc^{2}\check{M}.$

Let us consider$$\overset{}{B_{\alpha }^{a}}=\dfrac{\partial x^{a}}{\partial u^{\alpha }}.
\tag{2.5}  \label{2.55}$$We take $g_{ab}$ a nondegenerate metric on the manifold $M$ and $\mathbb{G=}g_{ab}dx^{a}\otimes dx^{b}+g_{ab}\delta y^{\left( 1\right) a}\otimes \delta
y^{\left( 1\right) a}+g_{ab}\delta y^{\left( 2\right) a}\otimes \delta
y^{\left( 2\right) a}$  the Sasaki prolongation of the metric $g$ along $Osc^{2}M.$

Thus, $\left\{ \overset{}{B_{1}^{a}},\overset{}{B_{2}^{a}},...,\overset{}{B_{m}^{a}}\right\} $ are m-linear independent d-vector fields on $Osc^{2}\check{M}.$ Also, $\left\{1\right) \gamma
}+B_{\delta \beta }^{b}v^{\left( 2\right) \delta }+\underset{\left( 1\right)
}{M}\overset{}{_{b}^{a}}B_{0\beta }^{b}+\underset{\left( 2\right) }{M}\overset{}{_{b}^{a}}B_{\beta }^{b}\right. - \\
\\
-B_{f}^{\bar{\alpha}}B_{d}^{\gamma }\left( B_{\gamma }^{f}+\underset{\left(
1\right) }{M}\overset{}{_{b}^{f}}B_{\gamma }^{b}\right) \left( B_{0\beta
}^{d}+\underset{\left( 1\right) }{M}\overset{}{_{g}^{d}}B_{\beta }^{g}\right)\end{array}
\tag{3.6}  \label{3.4}$$ *are mixed d-tensor fields*.

*The first relation is obviously. From \[1.3\] and \[3.2\] we obtain \[3.3\]*$.$

Generally, a set of functions $T_{j...\beta ...\bar{\beta}}^{i...\alpha ...\bar{\alpha}}\left( u,v^{\left( 1\right) },v^{\left(
2\right) }\right) $ which are d-tensors in the index $i,j$,..., and d-tensors in the index $\alpha ,\beta ,...$and tensors with respect to the transformations \[2.7\] in the index $\bar{\alpha},\bar{\beta},...$ is calld a *mixed* d-tensor field on $Osc^{2}\check{M}.$

The relative covariant derivatives
==================================

We shall construct the operators $\underset{\left( i\right) }{\nabla }$ of relative (or mixed) covariant derivation in the algebra of mixed d-tensor fields. It is clear that $\underset{\left( i\right) }{\nabla }$ will be known if its action of functions


}X^{\bar{\alpha}}=X_{\mid i\delta }^{\bar{\alpha}}du^{\delta }+X^{\bar{\alpha}}\overset{\left( 1\right) }{\mid }_{i\delta }\delta v^{\left( 1\right) \delta }+X^{\bar{\alpha}}\overset{\left( 2\right) }{\mid }_{i\delta }\delta v^{\left( 2\right) \delta }.$$Now, we can define the relative (or mixed) covariant derivatives $\underset{\left( i\right) }{\nabla }$ enounced at the begining of this section.

**Theorem 4.4**  *A relative (mixed) covariant derivation in the algebra of mixed d-tensor fields is an operator* $\underset{\left(
i\right) }{\nabla }$* for which the following properties hold*:$$\begin{array}{c}
\underset{\left( i\right) }{\nabla }f=df,\quad \forall f\in \mathcal{F}\left( Osc^{2}\check{M}\right) ~ \\
\\
\underset{\left( i\right) }{\nabla }X^{a}=\underset{\left( i\right) }{\check{D}}X^{a},\quad \underset{\left( i\right) }{\nabla }X^{\alpha }=\underset{\left( i\right) }{D}^{\intercal }X^{\alpha },\quad \underset{\left( i\right)
}{\nabla }X^{\bar{\alpha}}=\underset{\left( i\right) }{D}^{\bot }X^{\bar{\alpha}}~\left( i=0,1,2\right)\end{array}$$*The connection 1-forms* $\underset{\left( i\right) }{\check{\omega}}\overset{}{_{b}^{a}},\underset{\left( i\right) }{\omega }\overset{}{_{\beta
}^{\alpha }},\underset{\left( i\right) }{\omega }\overset{}{_{\bar{\beta}}^{\bar{\alpha}}}$* will be called the** connection 1-forms** of* $\ \underset{\left( i\right) }{\nabla }.$

**The Liouville vector fields** for submanifolds, introduce by profesor Miron1i\right) }{S}\underset{}{_{\delta }}\overset{}{^{\alpha }}\underset{}{_{\beta }}\underset{}{_{\gamma }}=\underset{\left( 12\right) }{R}\overset{}{_{\beta
\gamma }^{\alpha }}.\end{array}
\tag{5.6}  \label{5.6}$$$\left( i=0,1,2;j=1,2\right) $

This work was supported by Contract with Sinoptix No. 8441/2009.

[99]{} Atanasiu Gh. *New aspects in differential geometry of the second order*, Seminarul de Mecanica, Sisteme Dinamice Diferentiale, Univ. de Vest din Timisoara, Facultatea de Matematica, vol. 82, 2001, 1-81

Atanasiu Gh., *Structure equations of second order*, Proc. of The 5-th Conference of Balkan Society of Geometers, August 29-September 2, 2005, Mangalia-Romania, BSG Proccedings 13, Geometry Balkan Press, Bucharest, Romania 2006, 18-27

Bejancu A., *On the theory of Finsler submanifolds*, in Finslerian Geometry, Kluwer Acad. Publ.,Vol. 109, 2000, 111-129

Miron R., *The Geometry of higher order Lagrange spaces. Applications to mechanics and physics*, Kluwer Acd. Publ., FTPH no. 82,1997

Miron R., Atanasiu Gh., *Higher order Lagrange spaces*, Rev. Roum. de


precisely in inset of Fig. \[fig:dropL\](d). This dynamic feedback allows the droplet and the terrace to synchronize their motion. As implied by (\[eq:cont\_angl\]), we found that the synchronous propagation velocity depends on the layers thickness $H^+=Nl$ and will be discussed elsewhere [@YoPi:05].

![Numerical solution of Eq. (\[eq:non\_dimen\]), showing the freezing process (a-e) at respective time steps (from top to bottom: 0, 410, 581.85, 581.88 and 581.92). The horizontal range is $\xi=[0,120]$ and the vertical range is $\widehat h=[0,12]$. The dotted line in (c–e) marks the droplet position according to its maximal height. The inset shows the dependence of $\widehat h_c-H^+$ on time in the vicinity of the critical droplet volume. Parameters: $\chi=-0.3$, $\beta=15$, $\lambda=\sqrt{3}$, $l=2$, $H^+=2 l$, $H^-= l$, $\chi_\alpha=1.5$ and $\Delta=4$.[]{data-label="fig:dropR"}](frez){width="3.3in"}

In the freezing case, the droplet volume decreases, since the total massa display and book combination which allowed a calendar to swing forward to give access for a phone or reference book.
My U.S. Pat. No. 3,188,113 is for a Paper Holder with V-shaped pen receptacle, and has a display mount with pencil or pen holder formed therein but supported in a manner different from the present invention and requires five panels and supports the pens with a V-shaped pair of panels below the pen holding apertures.
In my prior U.S Pat. No. 4,299,643 for a METHOD OF MAKING A HINGED DISPLAY MOUNT a method of making a hinged display mount is shown of the type having a thin ductile hinge holding display panels in a predetermined position relative to each other and in which the hinge is preformed in a


done so, the court concludes that the bankruptcy court erred as a matter of law in formulating a "totality of circumstances" approach which excluded any consideration of the Debtor's pre-petition behavior, particularly as it relates to the Debtor's dealings with Grapski, his primary unsecured creditor, and other circumstantial evidence bearing on the Debtor's intent in proceeding under Chapter 13. Based on the record before the bankruptcy court, this court is left with the "definite and firm conviction" that a mistake was committed by the bankruptcy court in finding that the Debtor satisfied the "good faith" requirements of Chapter 13 under the circumstances of this particular case.

Analysis
The obligation of good faith is imposed on the debtor in a Chapter 13 *656 proceeding in two stages: First, the debtor mustof defaming Grapski with a false charge of child molestation in the course of a student government electoral campaign, and that McGovern never made any payments towards satisfaction of the $80,880.00 judgment entered against him prior to filing his Chapter 13 petition, instead opting to seek the protection of bankruptcy court the day before his compelled appearance at his deposition in aid of execution on the state court judgment. He borrowed $40,000 from his parents, on an undocumented loan, for attorneys fees to litigate the Grapski matter, and has no other substantial dischargeable liabilities other than the combined $30,000 in Grapski litigation related attorneys fees still owed to the law firms of Fowler White Burnett and Edna Caruso. There was no evidence that any other creditor except Grapski


Q:

Bike size - will a 2cm make a difference

I am buying a Cannondale Synapse 105. I have to buy used, not new.  There are two I am considering, they are identical except one is 54 cm and the other is 56 cm. My height is 5' 10/11".  I have read many articles on bike size.  Are there any experienced bikers here who can offer good guidance?

A:

Many people fall between two sizes and can get a smaller size or larger size to work, possibly with a few adjustments/parts (e.g. new stem, etc.).
You really have to try the bike to find out. I happen to be 5'11" as well, and my neighbor (who is also 5'11") did own a Synapse 105 (a few years ago; doubtThe present disclosure relates to person support apparatuses, such as beds, cots, stretchers, operating tables, recliners, or the like. More specifically, the present disclosure relates to person support apparatuses that include load cells.
Existing hospital beds and/or stretchers often include a load cell system that is used to detect the weight of an occupant of the bed or stretcher, and/or that is used as an exit detection system. When functioning as a scale system, the outputs of the load cells are read and a weight of the occupant is detected. When functioning as an exit detection system, the outputs of the load cells are read and used to detect when a patient has exited the bed or stretcher, or when a patient may be about to exit the bed


parts of the visitor center. The Refreshment Saloon, souvenir shop, lobbies, resource room and classrooms would still be available free of charge. There is no charge to enter the battlefield - something increasingly unusual at national parks, Latschar said.

"More parks charge fees than don't," he said. Season passes for repeat visitors have also been added to the proposal. Individuals could pay $32, and families would be charged $63. Latschar said it's difficult to know for sure, but he expects the struggling economy is affecting the way Gettysburg visitors are spending their money. "We think the economy definitely has some impact," he said.

Contact Erin James at ejames@eveningsun.com.

Proposed Fees:

Officials are proposing a single-admission fee that would cover the cost of seeing museum exhibits, a 22-minute film and the newly restoredas if his sleep had been released by the shout and his senses had returned from the wine into his breast, says,"what are you doing? what is this noise? by what means have i come here? where are you preparing to take me?"

Back

Card 3

Front

the unholy crowd approved the deed. then at last Bacchus (for it had been Bacchus)

Back

Card 4

Front

as if his sleep had been released by the shout and his senses had returned from the wine into his breast, says,"what are you doing? what is this noise? by what means have i come here? where are you preparing to take me?"

Back

Card 5

Front

"put aside your fear," said the bow-man "and tell us what ports you would like us to reach. you will be put on the desired land."


dealing with missing information and developing a statistical model which could learn the incomplete data are necessary. It is intuitively comprehensible that learning procedures would differ in missing data scenarios. We illustrate a novel example which could clarify what dealing with missing data means. Consider an image has missing information or lossy segments, and as a result, many pixels are lost or corrupted. In this setting, knowing the fact that the image is low-rank (few colors are used in painting for instance) helps restoration. As another illustration, suppose we have many athletes for whom specific records and measurements are gathered. The recorded features may have lots of features as not reported or not assigned (NA). Our purpose may be deriving the statistical model which determines the weight ofand data inference on large structures are based on algorithms which are computationally complex. The well-known algorithms for matrix completion in the literature are based on singular value decomposition in consecutive iterations which does not seem to be reasonable for big data scenarios as stated in [@esmaeili2016fast]. Therefore, the authors claim that it is sufficient to implement the completion algorithm for few iterations or even apply a simple (non-complex) completion method which leads to a good approximation of the support, and afterwards confine the data matrix on the approximated support. The next step in their proposed algorithm is to apply the complex and precise completion methods on the shrunken size data matrix so as to enhance prediction accuracy as well as reducing runtime. They also added a leg-up


known the data matrix as appeared in compressed sensing and regression problems differ from our case. Generally, there is no guarantee that we fully know the data matrix. In practice, we have several cases where this could happen. The data matrix entries could be missing due to costs in measurements, lacking access to report some data, inaccurate measurement device which leads to invalid report, and as a result, validation of the measured data is questioned. There are numerous practical settings suffering from the missing (corrupted) information such as massive MIMO, recommendation systems, medical datasets, etc. Thus, the problem is a generalization of the sparse recovery problem to a combined problem which has to recover the sparse parameters as well as inferring and completing the structure of data matrix.

**Input:**Q:

Keyboard shortcut to switch to result tab in SSMS

Does anyone know if there is any shortcut to switch tabs (editot,result, messages) in SQL Management Studio?
In my configuration i have enalbled option "Disply result in separate tab"

A:

Please use F6 to toggle between different tabs of SSMS.
Thanks,
Sree


INTRODUCTION AND CLASSIFICATION {#sec0005}
===============================

Since the 17th century, stroke has been recognized as a cause of age-associated cognitive impairment. However, until early in the 20th century, the prevailing concept of age-associated cognitive impairment causation was the impairment of cerebral blood flow (CBF) resulting from partial blockage of the vessels that supply the brain; thus, arteriosclerotic dementia resulting in global brain hypoperfusion was considered the most common form of major cognitive disorder in the elderly \[[@ref001]\]. Early neuropathologists recognized subcortical ischemic white matter injury and lacunes as typical lesions resulting from small-vessel disease \[[@ref002]\]. During the 1970s, amyloid-β (Aβ) plaques and neurofibrillary tangles were identified as critical components of the neurodegenerative process occurring in demented elderly patients \[[@ref003]\]. Alzheimer's disease (AD) became recognized as the most common form of majorthis expression was not related to severity of SSVD in the brains of elderly subjects lacking AD pathology in the OPTIMA cohort \[[@ref059]\].

Angiotensin II is a protein capable to damage aging cerebrovascular cells, particularly vascular smooth muscle cells; it shows increased activation with age and is linked to pro-inflammatory effects through activation of leucocytes, cell adhesion molecules, and inflammatory cytokines \[[@ref065]\]. It also leads to stimulation of NADPH oxidase, an important source of oxygen species production and downregulation of antioxidant defenses \[[@ref067]\].

Though speculative at this stage, it is interesting to note the results of informative parabiosis experiments in animals performed by Wyss-Coray and colleagues. They have found that by engineering a common blood supply between old and young mice they can detect a circulating factor in the blood


chromosome near the androgen receptor gene were associated with risk of VCI \[[@ref088]\], but to our knowledge, no follow-up studies of these gene variants have been published to date.

The gene for apolipoprotein E (*APOE*), a multifunctional protein involved in lipid and cholesterol transport and Aβ clearance, is the best-known risk gene for AD \[[@ref090]\] and CAA \[[@ref091]\] where the *ɛ*4 allele increases the disease risk. Meta-analyses of previously published candidate gene studies of *APOE* *ɛ*4 have shown significant association between *ɛ4* allele carriers and increased risk of VCI \[[@ref092]\]. Meta-analyses \[[@ref094]\] have also indicated that the *APOE* *ɛ*4 allele is associated with an increased risk of cerebral microbleeds \[[@ref095]\] but not with WMH \[[@ref096]\].

The *MTHFR* gene codes for an enzyme in the folate cycle, involved in homocysteine metabolismIn comparison with AD, the loss of visual memory is less pronounced in SSVD after one year, whereas the opposite is true for loss of physical independence \[[@ref110]\].

A number of simplified approaches to the diagnosis of cognitive impairment in SSVD have been proposed. In a study operationalizing MCI criteria, non-amnestic single-domain MCI was unexpectedly common and the authors concluded that it may represent a previously unrecognized MCI subtype associated with SSVD \[[@ref108]\]. The Frontal Assessment Battery is a useful tool to differentiate MCI due to SSVD from AD \[[@ref111]\]. The Montreal Cognitive Assessment performed better than the Mini-Mental State Examination to detect MCI-SSVD \[[@ref112]\]. The Cognitive Assessment Battery appears to be useful for MCI detection of MCI-SSVD \[[@ref113]\]. In an autopsy-defined cohort \[[@ref114]\], a combined memory and verbal