functional outcomes that cell motility might have on specific immune cell subsets, nor the correlation of MSC hypoimmunogenicity to *in vitro* cell tracking.

Conclusion
==========

We showed that MSC motility is a prospective indicator for MSC immunomodulatory potential. Although the heterogeneity of cell motility in MSC populations reduce the accuracy of the proposed method, it can be fruitfully used to indicate the overall potential of cell populations, especially in those with lower variability. In monoculture, fast MSC were more metabolically active and produced larger amounts of G-CSF, IL-6 and MCP-1. In co-culture with stimulated PBMC, fast MSC inhibited more efficiently IgG production, and correlated with higher IL-10 concentrations. The process of standardization of cell production --- *i.e.* MSC extraction, expansion and administration --- is fundamental in the application of MSC asTuesday, 21 February 2017

Taking Stock: February 2017

Making: Time to write is a struggle. It takes me time to break down a story and turn it into something that flows and makes sense. I don't like being rushed, I feel like stories need time to marinate like a good piece of chicken or meat. I need time to break down the moment and create it's meaning. I have to play with the words to find the right fit and believe me when i tell you it's tough finding the right words and putting them together in the simplest way possible. I have to figure out what the message is and how the reader will receive it. But I am a procrastinator when it comes tough challenges, I am afraid


I just buy them stuff. Does this make me a bad Aunty? ummmmm

Wishing: Men wouldn't attach so much negativity to love around Valentine's day. I am tired of hearing them drone on and on about how much they do. I wrote about ithere

Loving: A new face mask which I wrote about here. And a new hair masque which I will write about eventually.

Eating: Granola and yogurt, who knew they would make such a good combination? So to the people who've been posting breakfast Instagram pictures... I am sorry for being judgmental about the granola.Also along the lines of eating, I had my first meal at Cafe Ceylon. Totally worth it! I hope they maintain their standards because I shall be returning. The food was tasty and fresh. YouWest Coast have a secret weapon to combat Collingwood big man Brodie Grundy in Saturday's grand final - the most expensive ruck coach in AFL history.

Eagles pair Scott Lycett and Nathan Vardy performed admirably against sore Demons ruckman Max Gawn in last week's preliminary final win.

But the duo face an even bigger task to quell Grundy, who has been the form ruckman of the AFL finals.

Grundy monstered Richmond's Toby Nankervis last week, tallying 56 hitouts, 21 disposals and a goal in a shock 39-point win.

Don't miss the latest sports news! Was $13 now $7 per week for 12 weeks* (Digital + Print) Enjoy unlimited access to thewest.com.au and everyday digital editions on any device. Thursday - Monday papers home delivered with all of the latest footy news! *T&Cs


rucks the last few weeks. He's really invested in that. He's doing a really good job.

"He's got really good experience with every ruckman in the comp, so we'd be silly not to use him as a resource."

Play Video WATCH: Subiaco Oval was packed out on Monday as the Eagles held an open training session. The West Australian Video WATCH: Subiaco Oval was packed out on Monday as the Eagles held an open training session.

Suspended midfielder Andrew Gaff and injured defender Brad Sheppard have also been helping mentor teammates in their respective areas.

The duo were also in the coaches' box during the preliminary final win over Melbourne.

Simpson said it was important to include Naitanui, Sheppard and Gaff as much as possible to help them feel a part of WestLemma \[L:sta\], reading $\pi_{i_0}$ creates a peak at height $p$ in $D_n$ which is a contradiction.

The Corollaries \[C:Fin\], \[C:Cat\] bellow are immediate from Theorem \[T:cat\] and the following Propositions \[P:Dyc.h1\], \[P:Dyc.h2\].

\[P:Dyc.h1\] Dyck $n$-paths with no peaks at height $1$ counts the $n$-th Fine number.

\[P:Dyc.h2\] Dyck $n$-paths with no peaks at height $2$ counts the $(n-1)$-th Catalan number.

\[C:Fin\] ${S}_n(132,\hat 12)$ counts the $n$th Fine number.

\[C:Cat\] ${S}_n(132,\hat 123)$ counts the $(n-1)$-th Catalan number.

In this case, it is interesting that $|{S}_n(132,\hat 123)|=|S_{n-1}(132)|$.

When $p>n$, ${S}_n(132,\hat 123\ldots (p+1))=S_{n}(132)$.

This shows a discrete continuity from the Catalan sequence to itself.

Dyck paths with no $udd\cdots du$ {#S:31}
---------------------------------

Let $A$ be a sequence of distinct integers, then $A=A^L m A^R$, where $m$ is the greatest element in $A$ and $A^L$, $A^R$ are subsequences of $A$. We define recursively


in an indexed Dyck path $\theta(\pi)$ a *well-matching* pair. Conversely, by Lemma \[L:bij\], given a Dyck $n$-path, its steps are uniquely indexed by integers on $[n]$ to be an image by $\theta$. The following properties are straightforward from the construction of $\theta$:

1.  If two well-matching pairs are overlapped then the one with smaller index is nested within the other, [*e.g.*]{} ($\cdots u_5 \cdots u_2 \cdots d_2 \cdots d_5 \cdots$);

2.  Two consecutive steps $ud$ creating a peak are indexed $u_kd_k$ for some $k$;

3.  Two consecutive steps $du$ creating a valley are indexed $d_{k-1}u_k$.

\[T:udu\] Let $n,p$ be positive integers and $p\geq 3$. The map $\theta$ restricted on ${S}_n(132,(p-1)(p-2)\cdots 2\hat 1p)$ is bijective to Dyck $n$-paths with no $p$ consecutive steps $udd\cdots d u$.

Let $\pi  \in {S}_n(132,(p-1)(p-2)\cdotsor a starting point of a semi-circle;

3.  go-down one step if

    -   $i$ is a single point and $(i+1)$ is an ending point of a semi circular;

    -   $i$ is an ending point of a semi circular and simultaneously not a starting point of other semi-circular and $i+1$ is an ending point of other semi circle;

4.  do nothing if $i=n+1$.

\[T:mot\] The map $\psi$ defined above is a bijection from Motzkin $n$-paths to ${S}_{n+1}(132, 2\hat 13)$.

Let $M_n$ be a Motzkin $n$-path. By the construction of $\psi$, $\psi(M_n)$ is a permutation and its $LTRM$-blocks satisfy the conditions in Lemma \[L:ltrm\]. We prove $\psi(M_n)$ is $132$-avoiding by showing its $LTRM$-blocks pairwise non-overlapping (by Lemma \[L:132\]). Taking two different $LTRM$-blocks


photons perform a quantum walk along the network at the same time.

Another team has so far managed to do such quantum walks with one particle. But using two or more photons, means the number of outcomes increases exponentially. This allows the researchers to simulate highly complex situations that are outside of the number-crunching possibilities of today's fastest supercomputers.

Using the new technique, a quantum computer could, in less than ten years, be performing calculations that are outside the capabilities of conventional computers.A fly-back or switch-back voltage converter is a circuit to step up a voltage or to step down a voltage. For further illustration, FIG. 1 shows a circuit diagram of a typical fly-back voltage converter 10, which comprises a transformer 12 having a primary winding L1 coupled between an input voltage Vin and a switch M and a secondary winding L2 coupled between a capacitor Co and a controller chip 14. The controller chip 14 has an output pin EXT to provide a control signal S1 to switch the switch M, so as to transform a primary current Ip in the primary winding L1 into a secondary current Is in the secondary winding L2 to charge the capacitor Co to thereby produce an output voltage Vout, and a


at Bagram

Thank you for your service: Pence shook hands with one member of the 82nd Airborne Division. 1,200 soldiers from the 82nd were deployed to Afghanistan in September

Ghani expressed gratitude to the U.S. government and said Afghanistan's partnership with the United States was cemented in sacrifice.

Pence had originally planned to travel to Israel and Egypt this week, but he postponed that trip to remain in Washington while Congress passed legislation to overhaul U.S. tax law.

The short visit to Afghanistan was shrouded in secrecy for security reasons. Reporters traveling with the vice president were asked not to reveal his whereabouts until after the delegation arrived back at the air base from Kabul and Pence had addressed U.S. troops.

Pence, who coordinated the process that resulted in Trump's new Afghanistan policy,tough on Pakistan: Pence used his visit to Bagram to say that the U.S. was taking a tough line on Afghanistan's key neighbor

Posing: One Air Force servicewoman was delighted to meet the vice-president

Approval: Mike Pence gave a thumbs up as he greeted troops and civilians, among them soldiers frm the 82nd Airborne Regiment, the 3rd Infantry Division, and Rangers

Meet the boss: Mike Pence spoke with General John Nicholson, commander of US forces in Afghanistan

Key ally: Mike Pence met Afghan President Ashraf Ghani at the Presidential Palace in Kabul for talks

Talks: Mike Pence met Ashraf Ghani to give a message that U.S. troops are in the country to stay, a reverse of Trump's campaign promise of swift withdrawal

Inspection: Pence was greeted by an honor guard of Afghan troops at


   }

    private static void ceil(Calendar cal, int field) {
        cal.add(field, 1);
        cal.add(Calendar.MILLISECOND, -1);
    }

    public static String formatDA(TimeZone tz, Date date) {
        return formatDA(tz, date, new StringBuilder(8)).toString();
    }

    public static StringBuilder formatDA(TimeZone tz, Date date,
            StringBuilder toAppendTo) {
        return formatDT(cal(tz, date), toAppendTo, Calendar.DAY_OF_MONTH);
    }

    public static String formatTM(TimeZone tz, Date date) {
        return formatTM(tz, date, new DatePrecision());
 ? System.currentTimeMillis() : date.getTime()),
                new StringBuilder(5)).toString();
    }

    private static StringBuilder formatDT(Calendar cal, StringBuilder toAppendTo,
            int lastField) {
        appendXXXX(cal.get(Calendar.YEAR), toAppendTo);
        if (lastField > Calendar.YEAR) {
            appendXX(cal.get(Calendar.MONTH) + 1, toAppendTo);
            if (lastField > Calendar.MONTH) {
                appendXX(cal.get(Calendar.DAY_OF_MONTH), toAppendTo);


           if (ceil)
                ceil(cal, precision.lastField);
        } catch (NumberFormatException e) {
            throw new IllegalArgumentException(s);
        }
        return cal.getTime();
    }

    public static Date parseDT(TimeZone tz, String s, DatePrecision precision) {
        return parseDT(tz, s, false, precision);
    }

    public static TimeZone timeZone(String s) {
        TimeZone tz;
    popular in commercial, industrial and agricultural environments:

Design: A pre-engineered steel building can be designed to meet your exact business needs and according to certain specifications. This means that a pre-engineered steel building is fully customisable. You can also choose to build a standard steel structure in the size and dimensions you require

Building: The building of a pre-engineered steel structure is easy and hassle free. Building times are shorter than conventional building methods, and it is less labour intensive. The completed project will look professional and meet all your expectations.

Space: Steel buildings offer large spaces, horizontally and vertically. This makes steel buildings ideal for workshops, factories and warehouses, and other uses in commercial, industrial and agricultural environments.

Cost:Steel buildings are more affordable than conventional building methods. Get a pre-engineered steel


   *D*~x~ = 2.132 Mg m^−3^
  *a* = 5.4849 (11) Å           Mo *K*α radiation, λ = 0.71073 Å
  *b* = 14.302 (2) Å            Cell parameters from 981 reflections
  *c* = 18.354 (3) Å            θ = 2.4--27.4°
  α = 111.40 (2)°               µ = 2.48 mm^−1^
  β = 90.35 (2)°                *T* = 295 K
  γ = 94.03 (2)°   about 0.1 to about 20 seconds. Another reference of interest may be Canadian Patent No. 527,473 which discloses the use of variable tube diameters to control pressure drop and temperatures. U.S. Pat. No. 3,960,820 discloses a slug flow regime using steam injection to control residence time by pressure control. Other references of interest include U.S. Pat No. 2,689,839 and U.S. Pat. No. 3,357,955 which relate to additive additions or product quality adjustment of polyamides; and U.S. Pat. No. 3,300,449 which discloses a residence time of about 10 to about 120 minutes. U.S. Pat. Nos. 3,193,535 and 3,258,313 disclose a process with a tubular reactor which uses a high water content 47% by weight. In reviewing all these references it is clear that our novel aerosol jet polycondensation process


has not been contemplated by the prior art.
The general object of this invention is to provide a novel polycondensation process wherein the polycondensation is carried out in an aerosol jet regime at melt temperatures of about 500.degree. F. to about 750.degree. F. and contact times of about 0.1 seconds to about 20 seconds. A more particular object is to provide a novel condensation process for condensing aromatic carboxylic acids and anhydrides with diamines which are difficult to conduct under methods known to the prior art. Further, objects will be apparent from the description of the invention hereunder.
In our novel process we prepare a salt by reacting an aliphatic or aromatic diamine with di, tri or tetracarboxylic acids or their corresponding anhydrides or mixtures of the various acids orsulfone dianhydride, 3, 4, 9, 10-perylene tetracarboxylic dianhydride, 2, 3, 4, 5-pyrrolidone tetracarboxylic dianhydride, bis(3,4-dicarboxylphenyl)ether dianhydride; ethylene tetracarboxylic dianhydrides; 3,3', 4,4'-benzophenone tetracarboxylic dianhydrides, bis(3,4-dicarboxylphenyl)sulfide dianhydride, bis(3, 4-dicarboxylphenyl)methane dianhydride, 1, 4, 5, 8-naphthalene tetracarboxylic dianhydride and etc. The preferred tricarboxylic acid anhydride is trimellitic anhydride. It should be understood that tricarboxylic acids and their corresponding anhydrides like trimellitic anhydride are useful for the manufacture of polyamide-imides and tetracarboxylic acids and their corresponding anhydrides are useful for the manufacture of polyimides.
Aliphatic, cycloaliphatic and aromatic diamines useful in our process include the following: hexamethylene diamines, trimethylhexamethylene diamine, ethylenediamine, tetramethylene diamine, octamethylene diamine, nonamethylene diamine, decamethylene diamine, dodecamethylene diamine, 4,4'-diamino(dicyclohexylmethane), xylene diamine. The preferred aliphatic diamines include hexamethylene diamine and trimethylhexamethylene diamines.
Suitable aromatic diamines useful in our process include para- and meta-phenylenediamine,


polymers contain from about 10 to about 60% by weight glass fibers, glass beads, or graphite or mixtures thereof. The preferred range is about 30 to about 40%. Suitable reinforcing materials are glass fibers, glass beads, glass spheres and glass fabrics. The glass fibers are made of alkali-free boron-silicate glass or alkali containing C-glass. The thickness of the glass fiber is suitably on the average between 3 mm and 30 mm. The length of the glass fiber is not critical and both long and short glass fibers are suitable. Long fibers have an average length of from 5 mm to 55 mm and short fibers have an average filament length from about 0.05 mm to about 5 mm. Any standard commercial-grade fibers, especially glass fiber, may be used string temp;
    if (type==-1)
    {
        while (myinfile)
        {
            getline(myinfile,temp);
            cout<<temp<<endl;

        }
    }
    else if(type==0)
    {
        while (myinfile)
        {
            getline(myinfile,temp);
            if (temp[70]=='0')


                 ;ROOT DIR. GIVES US A DATA SECTOR AND WE WANT A LOGICAL SECTOR, WE WILL DO IT HERE
MOV AX, WORD [ENTERY_POINT]
ADD AX, 31                      ;31 ADDED TO DONE THE CONVERTION

CALL LOG_TO_HTS                         ;COVERTS THE LOGICAL SECTORS INTO HEAD TRACK SECTORS
MOV AX, 2000H
MOV ES, AX
MOV BX, WORD[OFFSET_]
POP AX
PUSH AX

INT 13H
JNC GET_NEXT
CALL RESET_DRIVE
JMP LOAD_SECTOR

GET_NEXT:
MOV AX, [ENTERY_POINT]
MOV DX, 0
MOV BX, 6
MUL BX
MOV BX, 4
DIV BX
MOV SI, TEMP
ADD SI, AX
MOV AX, WORD[SI]

OR  "

Based on the DOS 3.4 EBPB above and your boot.asm code, this BPB represents one similar to a 1.44MB floppy disk boot sector produced with mkdosfs -C floppy.flp 1440:
bits 16

section .text
start:
JMP MAIN
TIMES 3-($-$$) DB 0x90   ; Support 2 or 3 byte encoded JMPs before BPB.

; Dos 3.4 EBPB 1.44MB floppy
OEMname:           db    "mkfs.fat"  ; mkfs.fat is what OEMname mkdosfs uses
bytesPerSector:    dw    512
sectPerCluster:    db    1
reservedSectors:   dw    1
numFAT:            db    2
numRootDirEntries: dw    224
numSectors:


   ;RETRY IF INT 13H FAILED

LOAD_RD_DONE:
POPA
;NOW WE WILL SEARCH IN THE ROOT DIR. TABLE IF IT CONTAINS THE DESIRED FILE NAME WHICH IS KERNEL.BIN
;WE WILL USE CMPSB INSTRUCTION THAT COMPARES THE VALUE OF DS:SI AND ES:DI
;ES AND DS ARE ALREADY SET
;THE SEARCH WILL BE LIMITED TO SEARCH AMONG 11 BYTES BECAUSE THE FILE NAME IS 11 BYTES

MOV DI, TEMP                            ;THE RESULT WE GOT (THE ENTRY)
MOV CX, 224                     ;THE MAX. POSSIBLE FILE NUMBER THAT WE COULD HAVE IS 224 SOWE LIMIT THE SEARCH TO IT (THE VALUE THAT WILL BE DECREASED WHILE LOOPING)

FIND_KERNEL:
PUSH CX                         ;PUSH CX AND DI BECAUSE THEY HELD IMPORTANT DATA THAT WE DONT WANT TO LOSE
POP DX
MOV SI, FILE_NAME                       ;THE VALUE THAT WE WILL COMPARE THE RESULT OF ROOT DIR. TO FIND
MOV CX, 11


CODE FOR LOADING ROOT DIR.
MOV AL, 9                       ;THE SIZE OF THE ROOT DIR. THE ROOT DIR. = 14 AND WE WANT TO LOAD IT ALL SO AL=14
PUSHA                           ;TO BE ABLE TO RETRY TO LOAD ROOT DIR. IF INT 13H FAILED
LOAD_FAT:
INT 13H
JNC LOAD_FAT_DONE                       ;IF WE ARRIVE HERE, THATS MEAN THAT THE FAT LOADED SUCCESSFULLY
CALL RESET_DRIVE                       ;RESET FLOPPY FUNCTION CALL
JMP LOAD_FAT                            ;RETRY IF INT 13H FAILED

LOAD_FAT_DONE:                          ;IF LOADING FAT DONE SUCCESSFULLY, WE WILL BE HERE
MOV AH, 2
MOV AL, 1
PUSH AX

LOAD_SECTOR:                            ;ROOT DIR. GIVES US A


( element.type === "radio" ) {
				this.findByName(element.name).addClass(errorClass).removeClass(validClass);
			} else {
				$(element).addClass(errorClass).removeClass(validClass);
			}
		},
		unhighlight: function( element, errorClass, validClass ) {
			if ( element.type === "radio" ) {
				this.findByName(element.name).removeClass(errorClass).addClass(validClass);
			} else {
				$(element).removeClass(errorClass).addClass(validClass);
			}
		}
	},

	// http://docs.jquery.com/Plugins/Validation/Validator/setDefaults
	setDefaults: function( settings ) {
		$.extend( $.validator.defaults, settings );
	},

	messages: {
		required: "This field is required.",
		remote: "Please fix this field.",
		email: "Please enter a valid email address.",
		url: "Please enter a valid URL.",
		date: "Please enter a valid date.",
		dateISO: "Please enter a valid date (ISO).",
		number: "Please enter a valid number.",
		digits: "Please enter only digits.",
		creditcard: "Please enter a valid credit card number.",
		equalTo: "Please enter the same value again.",
		maxlength: $.validator.format("Please enter no more than {0} characters."),
		minlength: $.validator.format("Please enter at least {0} characters."),
		rangelength: $.validator.format("Please enter a value between {0} and {1} characters long."),
		range: $.validator.format("Please enter a value between {0} and {1}."),
		max: $.validator.format("Please enter a value less than or equal to {0}."),
		min: $.validator.format("Please enter a valuetrack record with quote-unquote open source licenses, I seriously doubt this will happen. If it does, it's going to be something like the "Sun Community Source License" a.k.a. the "We can take advantage of the latest buzz and still give nothing back to the community" license, which is nearly worthless since it makes it virtually impossible for people to make modifications to the source and be able to redistribute them. (See the Blackdown Linux JDK port for reference on how difficult it is to be an open development group and still work within the boundaries of Sun's SCSL.)

This is great news for all users of Star Office. Sun has said they plan to release almost everything under the Community Source License, and it is good to see them


much. Just My opinion thou. It will be nice if you find a bug, , but will you want to debug it? How long will it take to compile?

No doubt there are many proprietry components used in the development of Star Office. If the suite was open source, then either these components would also have to be open sourced, or there would have to be a lot of work put in to replace them with open source equivalents.

This would be a similar venture to Netscape open sourcing Mozilla. The question is, will this project (if it eventuates) suffer from community and developer apathy in the same way as the Mozilla project?

Sun buys a company for millions of dollars. Gives away the software on Solaris, Linux, and Windows. Andgoes further, and gives away the source with the only limitation being that you can't resell it without paying a fee, but you can share it with anyone you desire and make as many mods as possible as long as you redistribute for free. This to me is an INCREDIBLE GIFT for a corporation to do, and sure, they have motives for doing it (as all atruism is self-serving), and all the Slashdot kiddies can do is whine whine whine. Basically, the zealots here are like Christians who won't accept donations from atheists.

The one actual change to the program mentioned by Sun so far (aside from generally more interest in server distribution) has been their intention to switch to XML for better compatibility. This is fantastic overall, even


GPL help them achieve that goal. 2. That their users/developers would choose their products over non-GPL products because they have access to key technologies they can take home and use in other projects (Mozilla's Gecko renderer as activex object for example, or the Rhino drop in javascript on java product, or the XML renderer)--some how the decision to GPL now helps them find developers who use the exact same technologies in diverse industries but these developers as a result can contribute to the future health of Mozilla and Darwin/QT Streaming Server product)

22. GPLing SO will help business users with weather-worthy old computers to walk away from your SO-Customer relationship with less "abandonware" pains. When some SO developers and SO consultants move on to fresher products of the future--businessfrom a working Beowulf product).

18. A user like NASA doing the extending for you has a way of not only doing research for you. But supporting the product without you. Reselling the product without you. This is all very scary to those who rather entertain the possibility of one copy of software = one check sent to Sun economy--those in Sun and SO's competitors (MS/Corel/IBM/Apple). But the only one who can giggle AND be nervous at the same time is Sun/SO--because NASA would be using your software--not someone elses. Other's have nothing to celebrate.

17. Outside developers sympathetic to BeOS/MacOS/Research OSes/Embedded OSes/Evil Empire OSes/UN*X varients users would not forget your GPL'ed code base--they'll try to port these products to these platforms. To the users of these platforms--Sun would finally


About Me

I saw active service in conventional, clandestine and covert units of the South African Defence Force. I was the founder of the Private Military Company (PMC) Executive Outcomes in 1989 and its chairman until I left in 1997. Until its closure in 1998, EO operated primarily in Africa helping African governments that had been abandoned by the West and were facing threats from insurgencies, terrorism and organised crime. EO also operated in South America and the Far East. I believe that only Africans (Black and White) can truly solve Africa’s problems. I was appointed Chairman of STTEP International in 2009 and also lecture at military colleges and universities in Africa on defence, intelligence and security issues. Prior to the STTEP International appointment, I served as an independentsuit you to look elsewhere for contributors to this debate.

Eeben,Yes, I know you have concerns about me because I freelance with World Net Daily, but I'm presently working on a story about the Egyptian army's aggression against Christians since the removal of Mubarak.

What do you know about Chief of Staff Sami Enan, the presumed leader? And will he continue to either promote or allow the army to shoot-up the churches.

If you respond, I will not quote you directly, but say, 'A South African security and intelligence analyst who asks not to be identified says...'

I can use some help here, because the supposed experts over here in the U. S. are proving to be either ignorant or myopic.

Mr Barlow, Thank you for shedding light on Ivory Coast. From the


representing everyone, least of all its claims that it is an impartial broker.

Whereas the world is driven by interests – especially military and resources – I fear that we are watching a time bomb about to explode. This will require an even larger so-called UN peacekeeping force to intervene to keep peace where it does not exist.

Another article (I cannot verify its accuracy) dated 6 March stated that :”Thirty containers from Chad suspected of containing weapons were seized Friday, March 4, 2011 in by the local gendarmerie (police station) in Garoua-Boulai. These were containers of weapons destined for the United Nations Operation in Côte d’Ivoire”. I have to ask why the UN needed 30 more containers of weapons?

Choosing the UN as a tool, on a continent where theyfathoming how foul some people and organizations truly are - they are not even close to our moral baseline. Your experiences are invaluable bringing this out to the rest of us.

It is interesting that some of your commentators are from WND. There are no coincidences in life, they are a media outlet that gets hammered incessantly for asking questions. The modern media outlets of blogs etc are a true wing of the ongoing conflict on this planet between good and evil (doesn't that relate to Tsu?). But....I can see why you are very reluctant to give any journalist any purchase in your affairs. Your reply is, as I have found on this site, very classy.

Here in the states, we are wringing our hands about Libya. Intervene? If so,


such an inquiry from such a media-saturated situation? And do you believe, ultimately, that the Ivorian and Libyan civil wars are as you are indicating in your latest posts and comments (a propaganda campaign on behalf of anti-African interests)?

Egypt. Bahrain. Yemen. Libya. Is it a case of the CIA sure have been busy? There is a new wave of consciousness sweeping the arab world. I think however that they may just be booting out old despots to merely "democratically" vote in the next autocratic bunch. Power corrupts especially in areas where there are liquid assets in the ground. Where the un should be assisting is in natural disaster ravaged countries ala japan. Let them assist the civilians affected by the quake and tsunami.Mike

I am sorry for taking sois a Catch-22 situation but does the West really wish to go in with land forces? I suspect that the attacks will be long-range missile attacks coordinated with air strikes. However, there will be civilian casualties and we all know what happens then. I am sure that there will be a lot of West-bashing before this is over.

The nature of the beast is “do something and suffer the consequences of your actions”. Do nothing and likewise suffer.

What could a PMC do? First of all, there was a massive intelligence failure across the region. Governments were caught off-guard and were unable to react. When they did react, it was with violence as the argument was that an armed protestor is not a peaceful protestor. A PMC that goes in


that move to a title-contending team.

"Of course I would be lying if I said [leaving] doesn't touch me, of course I'm sad to leave Formula 1 and not to race," said Hulkenberg. "But if not here, there are other racing series where you can get that thrill."

So what are the 2020 options for Hulkenberg?

Well, he's already ruled out a reserve driver role in F1.

"To go and do that, when you're young and at the beginning, and I did that in 2011, I think that's the right and obvious thing to do," the 32-year-old stated.

"To do that when more advanced in the career, it's kind of a hard one to take when you've raced so many years consecutively. That role, I'm not sure about."

Despite links with Formula E andwork hard every day to put quality content out there for our community. Techdirt is one of the few remaining truly independent media outlets. We do not have a giant corporation behind us, and we rely heavily on our community to support us, in an age when advertisers are increasingly uninterested in sponsoring small, independent sites — especially a site like ours that is unwilling to pull punches in its reporting and analysis. While other websites have resorted to paywalls, registration requirements, and increasingly annoying/intrusive advertising, we have always kept Techdirt open and available to anyone. But in order to continue doing so, we need your support. We offer a variety of ways for our readers to support us, from direct donations to special subscriptions and cool merchandise


case has now moved on to the Supreme Court , which will likely hear the case in the fall. That may be a precursor to the final result in this case.

Filed Under: brca1, brca2, cafc, dna, gene patents, patents

Companies: aclu, myriad geneticsof limited significance for both critical and philosophical aesthetics. Indeed, they matter only to the extent to which they draw our attention to features or facts that we then identify, from our first-personal perspective, as aesthetically relevant - for instance, as reasons counting for or against certain ascriptions of aesthetic value, or as factors that causally influence our actual assessments and thus render them partly inadequate or irrational. This limited significance of empirical findings is in line with the rationalist approach to the formation and justification of aesthetic judgements, that I have already started to defend elsewhere. With respect to critical aesthetics, one problem is that empirical investigations cannot capture the normativity of the aesthetic relevance of lower-level features or facts: the respective studies can tell us what


we take to be reason-giving or valuable, but not what is reason-giving or valuable. Furthermore, we cannot use empirically knowable principles to infer the presence of aesthetic values or reasons on the basis of recognising measurable lower-level features because the only available principles are too specific to allow * Email: fabian.dorsch@uclmail.net. Website: www.ideengeschichten.de. 1 Fabian Dorsch The Aesthetic Relevance of Empirical Findings for their actual application to more than one existing object, or even for their actual formulation. For their antecedents make reference to a large number of very determinate properties, as well as sometimes to particular events of creation. The only exception are conceptual principles (such as 'something symmetrical is balanced') or default principles (such as 'something elegant is, by default, beautiful'). But knowledge of these principlestend to be more positive if we are more familiar with them should not be surprising. After all, familiarity is a condition on proper aesthetic evaluation and, in particular, on the recognition of aesthetic worth. It often takes time to be able to see the real value of an artwork. And this is not less true of genres or kinds of artworks which people are generally more exposed to - say, for reasons of fashion, or due to the fact that the art concerned is (presumably wrongly) now perceived as having lost its revolutionary or provocative status. It may be pointed out that the subjects concerned (i.e., students listening to introductory lectures in psychology, with the paintings serving as backgrounds for the presented slides) did not look at


ideally should have had no bearing. In other words, empirical evidence may show us that certain of our aesthetic evaluations are not of good aesthetic standing (or even not aesthetic in the first place). But it cannot weaken those standards, or replace them with new ones. It might be suggested that such investigations actually show that we are never really able to live up to this ideal and form proper aesthetic judgements. But this form of scepticism seems to be too strong. First, the studies are typically concerned with situations in which the subjects are ignorant about some very important facts about the objects concerned. That people get misled when assessing a white wine which they take to be red does not show that they get misled invalues of objects or the nature of those values. The so-called 'test of time' may perhaps serve as an illustration of this condition on the relevance of empirical evidence. Part of the explanation of why objects survive this test is that people (whether they are experienced critics or ordinary lay people) continue over the centuries and cultures to care about their preservation for aesthetic reasons (and not merely for financial or other reasons). So the survival of a given artwork provides us with empirical evidence - though, it seems, not (as Hume may have hoped) about its aesthetic value, but instead about the more general quality of our own evaluation of it. Having previously failed to appreciate Homer's Ulyssess, realising what it means for it to have survived


it might be a new species of Andinobates."

Andrew Crawford, professor at Universidad de Los Andes and former STRI postdoctoral fellow, sequenced the DNA, confirming that this was a new species of Andinobates. Genetic information about this species is available in the Barcode of Life Data System and in GenBank. A recording of the call is available at AmphibiaWeb.org.

Because this new frog species appears to be found in only a very small area, habitat loss and collecting for the pet trade are major threats to its existence. The authors recommend the formulation of special conservation plans to guarantee its survival. A. geminisae is included in the captive breeding program of the Panama Amphibian Rescue and Conservation project, a consortium of six zoos and research institutions dedicated to saving amphibiansbe a result of examining a particular realization of the data as a random sample, resulting in spurious identifications.'
author:
- Mariusz Tarnopolski
bibliography:
- 'bibliography.bib'
title: 'Multivariate analysis of BATSE gamma-ray burst properties using skewed distributions'
---

Introduction {#sect1}
============

Gamma-ray bursts [GRBs, @klebesadel] are separated into short [@eichler89; @paczynski91; @narayan92], coming from double neutron star (NS-NS) or NS-black hole (BH) mergers [@nakar; @tanvir13; @abbott1; @abbott2; @goldstein; @savchenko], and long ones [@woosley93; @paczynski98; @macfadyen99], whose progenitors are associated with supernovae Ib/c [@filippenko] connected with collapse of massive stars, e.g. Wolf-Rayet or blue supergiants [@galama; @hjorth; @stanek; @woosley06; @cano; @perna]. The division into these two phenomenological classes was first observed in the duration distribution by @mazets. Nowadays, the threshold is set at $T_{90} \simeq 2\,{\rm s}$ [@kouve93], where $T_{90}$ is the time during which 90% of the


[*Suzaku*]{}/WAM [@ohmori] yielded less unambiguous conclusions [@tarnopolski19b], although no clear evidence for a mixture of three components was found.

On several occasions, parametric clustering of GRBs was done in parameter spaces with dimension greater than two. @mukh performed multinormal modeling[^2] (in the space of $T_{90} - F_{\rm tot} - H_{321}$) that indicated three components in the GRB population. For the [*RHESSI*]{} data [@ripa12] multinormal fitting in the three-dimensional space of $T_{90}$, $H$ and peak-count rates also yielded three components. @chattopadhyay17 examined the complete BATSE data in a six-dimensional space[^3] (composed of durations $T_{90}$ and $T_{50}$, peak flux measured in 256 ms bins $P_{256}$, total fluence $F_{\rm tot}$, and hardness ratios $H_{32}$ and $H_{321}$). By means of a multinormal mixture model, they arrived at a conclusion that there are fiveF_4$ (1598 GRBs),

9.  $\log T_{90} - \log F_{\rm tot} - \log H_{43}$ (1598 GRBs),

10. $\log T_{90} - \log F_{\rm tot} - \log H_{32} - \log P_{256}$ (1927 GRBs).

Methodology {#sect2.2}
-----------

The methodology is the same as in @tarnopolski19a [@tarnopolski19b]. Mixtures of the following multivariate distributions are fitted: multinormal (Gaussian, G), skew-normal (SN), Student $t$ (T), and skew-Student (ST). The multinormal distribution is characterized by the location (the mean) $\bm{\mu}$, and the covariance matrix $\bm{\Sigma}$, with elements composed of the standard deviations, $\bm{\sigma}$, and correlations, $\bm{\rho}$. A mixture of $n$ components is characterized by $p=6n-1$ parameters. The SN distribution admits an additional skewness parameter, $\bm{\lambda}$. In total it requires $p=8n-1$ parameters. The T distribution is also characterized by $\bm{\mu}$ and $\bm{\Sigma}$, and by the number of degrees of freedom, $\nu$.


sets there are discrepancies, with differences as big as 6G vs. 2ST for $\log T_{90} - \log H_{43}$ (Fig. \[fig3\]), 8G vs. 3G/3T for $\log T_{90} - \log F_{\rm tot}$ (including $F_4 = 0$, Fig. \[fig6\]), or 8G/7G vs. 3ST for $\log T_{90} - \log F_{\rm tot} - \log H_{32} - \log P_{256}$ (Fig. \[fig9\]).

Based on the results of benchmark testing from Sect. \[sect3\], the $BIC$ appears to be more reliable than $AIC_c$ in such applications. In particular, $BIC$ was 100% accurate in detecting a 2G in the generated data, and yielded a higher accuracy than $AIC_c$ when 2SN was the true model (73% vs. 66%, respectively). Therefore, given such a strong tendency to overfit that was observed for the examined samples of BATSE GRBs, $AIC_c$ turns out not to be veryout " );
$('a').filter(function(index) { return $(this).text() === 'Link50'; }).removeClass('on');
});

A:

Here's a somewhat optimised version :
https://jsfiddle.net/fkhbcxzw/15/
linkScroll($('div.overout1'), 'Link30');
linkScroll($('div.overout2'), 'Link50');

function linkScroll(item, identify) {

    var object;

    item
    .on('mouseenter touchstart', function() {

        object = $(this).find('span');
        object.text('mouseenter-touchstart');
        $('a').removeClass('on').filter(function() {return $(this).text() === identify}).addClass('on');

        var offset = $('.on').position().top;
        var current = $('.links').scrollTop();
        $('.links').scrollTop(current+offset);
    })
    .mouseleave(function() {

        object.text('mouseleave');
    });
}

Because only a single action is needed on entering each div, it's better


but there was no significant difference in the changes in the size of the Mantoux reaction between the vaccinated group and the control group, with the exception of an unexplained increase in the size of the reaction in many of those who received rubella vaccine. Screening for tuberculosis by tine or Mantoux test is not invalidated by simultaneous administration of vaccines against measles, mumps, or rubella, given singly or in combination, as part of preventive care programs.function based on parameters of the class template, getting the code correct can be tricky. [temp.res]/p8:

If no valid specialization can be generated for a template, and that
  template is not instantiated, the template is ill-formed, no
  diagnostic required.

The trick is to have the SFINAE expression depend on parameters of the member function template:
template<std::size_t Selector>
struct impl {
    template<std::size_t S = Selector, typename std::enable_if<S == 1, int>::type = 0>
    static void apply(){
        std::cout << "First selector" << std::endl;
    }

    template<std::size_t S = Selector, typename std::enable_if<S == 2, int>::type = 0>
    static void apply(){
        std::cout << "Second selector" << std::endl;


We Are Afraid to Name and Shame

In the meantime, those who were tossed out of office by the public continue to preside over trials because their buddies and former colleagues keep using them as visiting judges. It’s a process that needs to stop.

While it is true that the drafters of Texas’s constitution wanted judges to be subject to the will of the people, I don’t agree with Paul that judges whom voters have rejected should not be able to sit as visiting judges. The drafters of the Texas Constitution got it wrong. As a result of our partisan judicial elections, the voters hire many incompetents (see, for example, Ruben Guerrero) and fire many great judges (see, for example, Caprice Cosper).

The point, in my view, is that our sittingBiomarkers in dementia with Lewy bodies: a review.
Dementia with Lewy bodies (DLB) shares common clinical, neuropsychological and pathological features with other dementia subtypes, such as Alzheimer's disease (AD), making it difficult to differentiate in clinical practice. Despite the development of consensus diagnostic criteria, many cases are missed, and biomarkers to assist with diagnosis would represent important advances. Our aim was to review the literature to identify potential biomarkers that may distinguish DLB from other dementia subtypes, especially AD. The literature search was performed using Medline up to October 2010 for imaging studies [single-photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI) and amyloid imaging] and cerebrospinal fluid (CSF) markers in DLB. Individual articles were examined for additional references. The abstracts of the identified articles


at 90% of maximum heart rate. During the stages, power output and rating of perceived exertion (RPE) were determined. Heart-rate recovery was measured after stage 3. Power output almost certainly (standardized mean difference: 1.0) and RPE very likely (1.7) increased from day 1 to day 8 at stage 2. Power output likely (0.4) and RPE almost certainly (2.6) increased at stage 3. From day 8 to day 11, power output possibly (-0.4) and RPE likely (-1.5) decreased at stage 2 and possibly (-0.1) and almost certainly (-1.9) at stage 3. Heart-rate recovery was likely (0.7) accelerated from day 1 to day 8. Changes from day 8 to day 11 were unclear (-0.1). The LSCT can be used for monitoring fatigue and recovery, since parameters were responsive to aUsing cluster analysis to explore survey data.
Llinos Haf Spencer reports on the use of the cluster analysis statistical technique in nursing research and uses data from the Welsh Language Awareness in Healthcare Provision in Wales survey as an exemplar She concludes that cluster analysis is a valuable tool to tease out patterns in data that are not initially evident in bivariate analyses and thus should be considered as a viable option for nursing research.


Q:

No more than 9 arguments in QString arg? How to deal with it?

I write a long QString with more than 9 arguments, I simply use it like this:
QString html = QObject::tr(
                "%1 %2 %3 %4 %5 %6 %7 %8 %9 %10 ...").arg(a, b, c, d, e, f, g, h, i, j);

But QtCreator yields and error, that there can not be more than 9 args ... I read the docs: http://doc.qt.io/qt-5/qstring.html, where there is an arg function definition:
QString    arg(const QString & a1, const QString & a2, const QString & a3, const QString & a4, const QString & a5, const QString & a6, const QString & a7, const QString & a8, constNEW YORK -- Fred VanVleet has everybody's attention. The Toronto Raptors guard is not only a part of the best bench in the NBA and the league's best five-man unit, his coach counts on him in crunch time. When he made a game-winning jumper in the corner on national television last week, it shouldn't have been seen as surprising. As unlikely as it might seem for an undrafted, undersized floor general to emerge as a crucial part of the team that is tops in the East, VanVleet has spent his whole season showing that he belongs.

Per 36 minutes, VanVleet has averaged 15.2 points, 5.7 assists, 4.7 rebounds and 1.7 steals while making 39.4 percent of his 3s and pestering opposing guards on defense. He has become a fan


a lot of hard choices growing up, and my brothers made a lot of hard choices. My brothers took a lot of the hits for me. My dad, my mom, they took a lot of the hits for me and my family. A lot of people sacrificed for me. Nobody sacrificed more than me, obviously, but that's the biggest thing. You gotta sacrifice so much and just make so many critical decisions just to make it out of that situation. You know what I mean? And it's that simple sometimes.

But it's making those decisions every day, right?

VanVleet: It's all day. Every day. Mom and dad are working, are you going to get up to go to school? You don't have to go to school. You'll probably get your4:3, it has export settings for small (176 x 120), medium (352 x 240), custom (defaults to 720 x 480, im sure there's a way to change that but ive not found that yet), fullscreen DV/MJPEG and Nintendo Wii SD (all default to same as custom). the sizes of the files in terms of space vary depending on how long it is or how many A/V tracks used, usually if its not a long video like most of my stuff it'll be under 400-500MB using the custom setting. when i upload videos, i usually delete them from my computer afterwards to save space because i only have 20GB left

Fam when you get msg in the distant year 20XX can you delete rp pages I mean it's fine if


to fix him. In counseling, she learned that she had to put herself higher on her list of priorities.

Obama praised the courage of her daughters, who had to grow up and try to live normal lives while surrounded by Secret Service agents. When she was asked by students she met Thursday if she would run for president, Obama responded, "Heck no. I'm not going to do that to those two people (Malia and Sasha)."

At some point, leaders need to pass the baton on to the next generation, Obama said. But she expects to be involved with public service for the rest of her life. "Public service is who we are … it fills us up," she said.that it might never see a full release. While the game still isn’t in full release, today’s launch into Steam Early Access is a huge step in that direction. Needless to say, fans are ecstatic to get their hands on this new version.

World of Horror is one of those games that’s hard to tell what it is at a glance. Excellent spooky MS Paint drawings, the game? Well, that’s part of it. World of Horror at its core is a CRPG. It’s very easy to see how World of Horror would fit right into the library of old DOS games. You play as one of seven (initially five) characters living in a small Japanese coastal town in the 1980s. Recently, a strange series of events has caused things


mix of easy to play and hard to master. There’s a shit load of stuff in World of Horror, but you don’t really need to learn most of it when you start. The core gameplay loop is clicking explore and dealing with the consequences. Most of these consequences come in the form of randomized events that ask you to pick from a few options. For example, do you search a room, or run out the door? Pretty basic stuff. Often times one of these options will be greyed out depending on if you have a certain skill/item/companion. Picking any of these options will initiate a skill check. If you pass the check, good things happen. If you fail, bad things happen. Your chances of success can be improvedwith a basic stat system you’ve come to expect from any RPG.

You’ll also be forced to confront a variety of monsters in World of Horror. Monsters spawn in a pseudo-random fashion, but all function similarly. You just need to get their health bar to 0 before they do the same to you. You fight by stringing together a series of actions, each with their own energy cost dependant upon a corresponding stat. You can build your combo up to a cost of 200, then perform all the actions in order. Then the monster takes a turn to do their thing. Repeat until dead.

I’m simplifying things here, but that’s all you really need to know to get into World of Horror. Much of the game’s complexity is discovered piecemeal.


Introduction {#s1}
============

The rapid advances of systems neuroscience and growing interest in structure and dynamics of large-scale brain networks adds extra impetus to the need to understand the basic building-blocks of thalamocortical connectivity. The thalamus can synchronize activity across multiple nodes of cortical networks according to attention demands ([@BHV063C73]) and is a component of a tightly connected "central core" of brain regions engaged by multiple tasks and behaviors ([@BHV063C53]). As it simultaneously modulates activity in cortical regions, the thalamus constitutes a set of key connector hubs for cortical networks. Improved knowledge of the spatial layout of those thalamic hubs, and the functional networks into which they are integrated and modulate, would influence models of human cortical function.

However, the structure and function of *human* thalamus has been an area ofthalamic injuries ([@BHV063C17]). Interrogating such case studies, [@BHV063C50] were able to coarsely segment subcortical patterns of known frontal-striatal-thalamic loops (see [@BHV063C3]) based on behavioral impairment in patients with spatially varied subcortical injuries. Focusing more directly on connectivity, [@BHV063C77] further investigated 2 case studies of focal thalamic lesions, indicating that the very different behavioral profiles in 2 thalamic stroke patients may be explained by their different structural connectivity profiles to the rest of the brain. Lesion studies represent a blunt example, but these associations between regional structure and cognitive or behavioral function can also be detected in healthy populations. Using a similar diffusion connectivity approach, [@BHV063C63] demonstrated that white matter indices along specific thalamocortical bundles relate to individual differences in expected domains, for example, radial diffusivity along the bundle


initially downloaded, although 107 were later excluded due to inclusion and exclusion criteria (see below).

Data Inclusion and Exclusion Factors {#s2b}
------------------------------------

Previous work has demonstrated changing functional connectivity during childhood ([@BHV063C27]) and changes (reductions) in brain volume are largely linear with age between 18 and 65 years ([@BHV063C74]), so this analysis was restricted to participants aged 18--65 years old. These age criteria led to an initial exclusion of 71 datasets. This study made use of 3 of the available MRI modalities from each dataset. For all subjects, a *T*~1~-weighted image, a resting-state fMRI time series and a diffusion-weighted dataset were required in order to undertake the planned analyses. Any dataset without all 3 of these was therefore excluded (4 excluded). Finally, the fMRI data were assessed based on interscan framewisethe functional connectivity t-maps. This similarity matrix was then clustered using affinity propagation ([@BHV063C29]), with median similarity of the functional connectivity maps to each other acting as the initial preference value. To illustrate regions of the brain driving the clustering solution, conjunction tests ([@BHV063C57]) were performed across the functional connectivity maps for each cluster. This results in maps that demonstrate only voxels that show significant functional connectivity in *all* maps assigned to each cluster, and hence summarize the shared functional connectivity of a set of thalamic structural connections driving the clustering solution. Figure [1](#BHV063F1){ref-type="fig"} illustrates a simple breakdown of the analysis pipeline. Figure 1.Basic workflow showing the main analysis steps in this experiment. After image preprocessing including spatial registration, probabilistic tractography is performed from every voxel in the


(left), tractography-defined connectivity (middle), and functional connectivity (overlap across all images assigned to the set in the clustering solution, right). Top left, "set 1": The most medial cluster of thalamic components were functionally connected with medial orbitofrontal cortex, bilateral middle temporal gyrus and bilateral hippocampus, as well as posterior cingulate and retrosplenial cortex posteriorly. The resulting tractograms resembled aspects of the fornix as well as simple thalamofrontal bundles. Bottom left, "set 2": This cluster of thalamic regions, more lateral to the first, showed functional connectivity with ventral anterior cingulate, ventral caudate and anterior putamen. Top right, "set 3": The third cluster was functionally connected to a bilateral frontoparietal network including middle frontal gyrus (encompassing Broca\'s area), ventral frontal opercula, and bilateral posterior supramarginal gyrus. In addition, midline structuresof a large similar cluster into 2 distinct sets (see Fig. [2](#BHV063F2){ref-type="fig"}).

Sets 5 and 6 (Fig. [4](#BHV063F4){ref-type="fig"}) appears to overlap ventral lateral and ventroposterior nuclear regions. In the macaque, the ventroposterolateral (VPL) nucleus projects to primary motor and premotor cortices ([@BHV063C69]; [@BHV063C54]). In rhesus and other monkey species, ventroposterior cortex connects to insula ([@BHV063C15]; [@BHV063C56]). Corticothalamic connections have been demonstrated in the rhesus monkey between posterior parietal cortex and ventral lateral, ventroposterior and lateral posterior nuclear regions ([@BHV063C90]), overlapping with regions seen here; with rostral-superior to caudal-inferior cortical regions connected to these nuclei in an anterior-posterior arrangement.

Set 7 appears to overlap with lateral posterior nucleus and, most probably, the pulvinar. In the rat, this region is extensively connected with medial and lateral parietal and occipital cortex ([@BHV063C45]). Connections


in monkeys have also been noted to posterior parietal ([@BHV063C90]) and insular ([@BHV063C15]) regions. Connections with frontal eye fields have not been noted specifically from this nucleus, but from nearby ventral lateral, parafascicular, and medial pulvinar regions ([@BHV063C41]). Overlap with the pulvinar is presumably mostly with medial pulvinar since this is substantially bigger than lateral pulvinar in rhesus monkey and man ([@BHV063C68]). The lateral pulvinar connects to an extended region of the lateral temporal cortex stretching down to the temporal pole. Although the lateral pulvinar is certainly represented in this parcellation of the thalamus itself, this set appears to be dominated by functional connectivity more representative of the medial pulvinar. The medial pulvinar has connections with inferior temporal ([@BHV063C12]) and superior temporal cortex ([@BHV063C68]) but also inferior parietalIf you love national politics and follow it closely, there’s always the debate you imagine in your head and the one that later happens on the screen. Before Wednesday’s Democratic debate I made a list of the bare, bottom-line message I thought each candidate had to deliver.

Mike Bloomberg: You can stomach me.

Bernie Sanders: You can stomach...


two separate trains that never cross tracks. Their only link is Blacksmith (spoiler alert: It’s Colonel Schoonover, played by Clancy Brown), and even his death only scratches the surface.

For Marvel fans, the teasing promise of tomorrow is always meant to inspire hype and momentum. But for those who care about the MCU, it’s maddening when major threads are left dangling and Daredevil leaves maybe too many mid-breath, mid-conversation.

But there’s no hero shot. There’s no whisking away the bad guy in a cop car. There’s no victorious brooding on a rooftop. There’s some corny voice over from Karen, yeah, but it’s the kind of cheesiness that works with Daredevil’s general rebellion. Daredevil doesn’t end with brooding shots against sun rises, it just ends.when compared to LW, the EHL piglets showed elevated serum total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol, as well as higher liver content of cholesterol \[[@B5]\]. In type 1 diabetes the liver mitochondrial proteome shifts to support ATP production \[[@B34]\]. The EHL piglets, which has lower serum insulin than LW, gets higher hepatic OXPHOS activity.

To our surprise, reduced mtDNA copy number was detected in the liver of the EHL piglets, indicating lower mitochondrial biogenesis. Improved hepatic mitochondrial function is usually associated with enhanced mitochondrial biogenesis, which sometimes corresponds with up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α, *PPARGC1A*) \[[@B35]\]. *PPARGC1A* was up-regulated in several liver transcriptome datasets when treated with dexamethasone \[GSE24255, GSE24256 and GSE34229\], but did not differ between EHL and LW piglets


Q:

Will the GC dispose/deallocate the memory allocated in jni automatically on Android?

I allocate the memory and new the ByteBuffer object in JNI as following:
uint8_t* pBuffer = (uint8_t*)malloc(size);
// fill the pBuffer
jobject byteBufferInJni = (*env)->NewDirectByteBuffer(env, pBuffer, size);

Then pass the byteBufferFromJni to Java layer like this:
callback(byteBufferInJni);

In java layer, get the Object byteBufferInJni.
The question is:
If i dereference the byteBufferInJni in java, like this:
byteBufferInJni = null;

Will the pBuffer disposed/deallocated by GC ?

A:

Nope, the JVM does not know that malloc was used and the memory should be deallocated with free. If the ByteBuffer was to call free automatically, the JVM would crash if the memory is statically allocated:
#include <stdlib.h>

int main()
{
    char *str = "Hello, World!";
    free(str); // Never do this!
}

It is your responsibility to free it.drilling operation through the workpiece in a direction perpendicular to the main spindle, and a drilling operation at an offset position of the axial center of the main spindle. If the main spindle is set as the reference axis, such operations are disabled under electronic-cam control since any reference signal is not generated from the stopped main spindle.
The electronic cam control utilizes command position data of a moving axis respectively set for every unit rotational position of the main spindle, thereby achieving higher accuracy with higher speed. If the main spindle is stopped, a pulse signal is not generated, therefore command position data of a moving axis respectively set for every unit rotational position of the main spindle is not obtained, then a moving command data is not


in Georgia, announced it will begin a hiring freeze and offer voluntary leave to employees. https://t.co/YXwxABTdtz — AJC (@ajc) March 11, 2020

» Birthday party for John Lewis is the latest casualty in coronavirus scare

1 p.m.: Cobb has created a coronavirus task force to prepare the county for the possibility of an extended shutdown, Meris Lutz reports. Among changes the task force has already implemented are compiling a list of which employees need remote network access to continue county services, adopting an emergency closure policy and adjusting workers' comp to include employees exposed while on the job.

10:30: The State Road and Tollway Authority announced it has begun "deep cleaning" 10-15 buses a day that are part of metro Atlanta's Xpress bus service, AJC transportation reporter David Wickert wrote. Thein its fully upright position would allow, and she quivered, absolutely quivered, from panty-draped ankles to self-mussed hair. Her moan sounded all the more intense for its courteous softness.

And Jared got his money's worth out of Maxwell Zirbin's big purple handkerchief. He pumped for what seemed like forever as he inhaled her aroma, contorted his eyes shut, and visualized a night sky of milky clouds over the Atlantic.

Just when he had milked himself dry, he heard her voice again.

"Want a taste?" She sounded shy, but somehow confident. He opened his eyes. Her fingers, held aloft, were glistening, and her pupils were sparkling.

Without hesitation, he leaned forward and sucked one finger, then another, then another.

"Nice," he commented, feeling suddenly drunk with impetuousness, and completely at ease. "You taste like


by it. He ignored my efforts to engage him in conversation, and simply drank his gin and flipped through the in-flight magazine. Finally, he looked up from the article on the Dutch bulb fields he'd been studying as though it was the most fascinating thing he'd ever read, clearly amused by my growing impatience.

He glanced round at our fellow passengers. The few who were sitting near us were either reading or trying to doze. The  empty glasses and sandwich wrappers had been cleared away and the flight attendants were more than likely busy in the galley. The plane was quiet apart from the low, constant whine of the engines and the rumbling snores of a man in the seat behind me. No one was paying us theSmall steps toward thriving families, schools, and communities

Main menu

Post navigation

Grade Fog

Props to Tyre for clearly posing the question. “Should students be rewarded for being friendly, prepared, compliant, a good school citizen, well organized, and hard-working? Or should grades represent exclusively a student’s mastery of the material?”

The buzzword is “standards-based grading”.

The better question is whether grades should represent exclusively a student’s mastery of the material or whether more subjective variables such as their attitude, citizenship, and effort should also be taken into consideration.

It’s hard to disagree with the standards-based graders assertion that assessment must rest primarily on mastery of course material. I want master pilots, plumbers, surgeons, and bridge builders. The question though is how far down that road to travel. For example, inevitably some students can demonstrate mastery


open/close the upper opening of the main body. In the prior art probing apparatus, however, the load of the test head T is applied to the probe card 7 and so is the reaction force of probing pressure exerted in the inspection. The load and force deform the head plate 8 and, in this case, the head plate 8 is not deformed uniformly and thus the probe card 7 inclines. As a result, the prior art probing apparatus has the problem that the probes 7A cannot be brought into stable contact with an electrode pads of an object to be inspected.
It has been recently contrived to screw the head plate 8 on right and left receiving seats (not shown) provided in front of the probing chamber 2 whenmodule Forem
  class TopicsController < Forem::ApplicationController
    helper 'forem/posts'
    before_filter :authenticate_forem_user, :except => [:show]
    before_filter :find_forum
    before_filter :block_spammers, :only => [:new, :create]

    def show
      if find_topic
        register_view(@topic, forem_user)
        @posts = find_posts(@topic)

        # Kaminari allows to configure the method and param used
        @posts = @posts.send(pagination_method, params[pagination_param]).per(Forem.per_page)
      end
    end

    def new
      authorize! :create_topic, @forum
      @topic = @forum.topics.build


 @topic.posts.build
    end

    def create
      authorize! :create_topic, @forum
      @topic = @forum.topics.build(topic_params)
      @topic.user = forem_user
      if @topic.save
        create_successful
      else
        create_unsuccessful
      end
    end

    def destroy
      @topic = @forum.topics.friendly.find(params[:id])
      if forem_user == @topic.user || forem_user.forem_admin?
        @topic.destroy
        destroy_successful
      else
        destroy_unsuccessful
Clinical outcomes after salvage radiotherapy without androgen deprivation therapy in patients with persistently detectable PSA after radical prostatectomy: results from a national multicentre study.
To assess oncologic outcomes after salvage radiotherapy (SRT) without androgen deprivation therapy (ADT) in patients with persistently detectable PSA after radical prostatectomy (RT). Two hundred and one patients who failed to achieve an undetectable PSA received SRT without ADT. The primary endpoint was failure to SRT that was defined by clinical progression or use of second-line ADT. Clinicopathological parameters, 6-week PSA level, PSAV and pre-SRT PSA levels were assessed using time-dependent analyses. Median postoperative 6-week PSA and pre-SRT PSA levels were 0.25 and 0.48 ng/mL, respectively. Median time between surgery and SRT was 7 months. Failure to SRT was reported in 42.8 % of cases


I love everything about being a gypsy. From their clothing, to their jewelry, to their traveling homes. I can feel the winds of change coming on. I usually have to confide in my sister, Michelle, and she can talk me down. Thank you, Michelle. 🙂

BedroomBathroom

I could spend all day in these rooms. WHICH………..

Brings me to another past life. Maybe it was the same past life…IDK.

2. Old West Performer

Don’t judge. HAHA!

I love old west ghost towns, saloons, old trains, the thought of gun fights. It’s like I’m connected somehow. Silverton, Colorado is a perfect example. I love just being there. I enjoy chuck wagon dinners like the Bar D and feel like I fit right in.

What were you in your past life? Do you believe in life after death?and two more applications for an acceptance into the film program. Little is a Mormon. While at BYU, he made over twenty short films.

Professional career
The idea for his first professional film Saints and Soldiers was inspired by his religion professor at Brigham Young, Dennis A. Wright. Wright was the coauthor of a book Saints at War, and he shared some stories with Little that he wished could have been in the book but had to be left out. Little was able to contact the veterans that Wright told him about and with their help, he wrote the story of Saints and Soldiers. The film, which takes place during World War II, is about three soldiers who escape during the Malmedy massacre.

One key element found in most of


WASHINGTON, July 11 (Reuters) - The Republican chairmen of two U.S. House of Representatives committees asked the Justice Department on Monday to launch an investigation into whether Democratic presidential candidate Hillary Clinton committed perjury during testimony to Congress about her use of a private email server.

SEE ALSO: GOP figured closer to being Trump VP with major meeting

"The evidence collected by the FBI during its investigation of Secretary Clinton's use of a personal email system appears to directly contradict several aspects of her sworn testimony" to Congress, House Oversight and Government Reform Committee Chairman Jason Chaffetz and House Judiciary Committee Chairman Bob Goodlatte said in a letter to U.S. Attorney Channing Phillips requesting the probe.

See reactions from the FBI's decision against charges:

16 PHOTOS Reaction to FBI director's statement onon the House Oversight and Government Reform panel, accused Republicans of a political vendetta following years of Republican-led investigations of Clinton in the House.

SEE ALSO: David Cameron caught on hot mic

"Republicans are now squandering even more taxpayer dollars in a desperate attempt to keep this issue alive and bring down Secretary Clinton's poll numbers ahead of the election," Cummings said.

Clinton has said that she did not believe she was handling classified information on the private email system.

Chaffetz has also asked the Federal Bureau of Investigation to give him access to its investigative files on Clinton. (Reporting by Richard Cowan; Editing by James Dalgleish and Peter Cooney)

More from :

Obama and Clinton roast Donald Trump

FBI vs. Clinton: Seven points of contention

Bernie Sanders is (finally) expected to endorse Hillary Clinton


beautiful angel and scorched demon. Heaven and Hell indeed. Add onto this the union of these highly proficient musicians with a backdrop of epic synthesizers and you have yourself something special. I'm not sure how all of these people came together, but it certainly worked out nicely. And guitar players, they've got plenty of ripping solos with which to make your fingers bleed.

So many great hits on Miserycorde: "The Tribulation of Man," "Catabolic (I Am)," "Quandaries Obsolete." I could go on. And from moment to moment the aesthetic is making subtle shifts between various subgenres from symphonic to deathcore to blackened death, and beyond. It's a very interesting listen. None of these components are particularly shocking in isolation, but this particular arrangment of them together is not oneLooker Story

Sherry Mathis

The investigator — a passion for people and the truth

Sherry MathisLooker and life-long investigator, both by trade and natural calling.

Location: Azusa, California

Looker Since: 2013

Special Skills: Pro Team

Sherry Mathis is a life-long investigator, both by trade and natural calling. The daughter of an immigrant from a small town in Mexico City, she has lived her entire life in Southern California and currently resides only a short distance from the foothills of the San Gabriel Mountains near Los Angeles.

Sherry began her investigative career with a degree in Criminal Justice and later became an Inglewood, CA, police officer. She then became involved with retail investigations for a couple of large retailers. During her twelve years as an investigator of employee theft, she learned how to communicate with people and


weekdays manually:
#include <boost/date_time.hpp>

using namespace boost::gregorian;

long dateDifference( string start_date, string end_date )
{
    date _start_date(from_simple_string(start_date));
    date _end_date(from_simple_string(end_date));

    // counter for weekdays
    int cnt=0;
    for(day_iterator iter = _start_date; iter!=_end_date; ++iter)
    {
        // increment counter if it's no saturday and no sunday
        if(    iter->day_of_week() !=  boost::date_time::Saturday
            && iter->day_of_week() !=  boost::date_time::Sunday)
            ++cnt;
    }
    return cnt;
}

Answer ported from this answer: https://stackoverflow.com/a/7342989/3187827

Co-expression of YieF and PhoN in Deinococcus radiodurans R1 improves uranium bioprecipitation by reducing chromium interference.
Overexpression of the enzyme phosphatase (PhoN/PhoK) in the radiation-resistant bacterium Deinococcus radiodurans could be an efficient strategy for uranium remediation. However, the presence of other metals in nuclear wastes often interferes with uranium bioprecipitation. In our study, the uranium-precipitating ability of the PhoN-expressing D. radiodurans strain (Deino-phoN) significantly decreased by 45.4% in 13 h in the presence of chromium (VI); however, it was partially recovered after supplementation with chromium (III). Therefore, the reduction of chromium (VI) to chromium (III) was obtained by the co-expression of the YieF protein and PhoN in D. radiodurans (Deino-phoN-yieF). As a result, an increase in the chromium (VI) reduction (25.1%) rate was observed in 24 h. Furthermore, uranium


in the example of needing a new car, it could be that it might be better to pay a bit more insurance so that you can get a hire car if your car is out of use or perhaps you might be able to pay for a hire car, use a family members car, use public transport or get a lift with someone. It can be easy to panic about what you might need to replace, but we can actually manage with a lot less than we might think. It could really be the day to day things that are more important.

For example, if you have a cash flow problem, then it could be paying bills, rent and buying food that could be more of a concern. HavingPRMT5) catalyzing the formation of symmetric dimethylarginine \[[@B7], [@B8]\]. Previous studies reported that hypoxia- and ischemia-induced apoptosis in human lung epithelial cells in pigs was regulated by the activation of PRMT1 and PRMT5 \[[@B9]\] and that the expression of PRMT5 was increased in the renal tubular epithelium of the animal model of ischemic/reperfusion injury \[[@B10]\]. However, the role of PRMT5 in oxidative stress and inflammation induced by renal I/R has not been elucidated.

Increasing evidence indicated that the generation of reactive oxygen species (ROS) and the inflammatory response affected the severity of renal I/R injury \[[@B11]--[@B13]\]. Ischemia-induced dysfunctional mitochondria lead to an abundant production of ROS, followed by the activation of inflammasomes, which are mediators of inflammatory responses. Simultaneously, activation of inflammasomes can be repressed by antioxidants, such as


her like a “sexual object that he felt entitled to humiliate and dominate.”

Johnson alleged that during their encounter, Trump “tightened his grip” on her, getting so close that “she could feel the breath on her skin.” She also said that Trump tried to kiss her on the mouth, but that she turned her head to avoid it. (RELATED: Trump Lawyer: Video Shows Ex-Campaign Staffer Lied About Forcible Kiss)

“Defendant Trump kissed her anyway, and the kiss landed on the corner of her mouth,” Johnson alleged.

But Trump’s lawyers released a video of the incident on July 11 that undercut some of Johnson’s story.

The footage shows Trump and Johnson on an RV surrounded by campaign officials and staffers. Johnson is heard off-camera initiating conversation with Trump, who responds by approaching Johnson1521
(7 years ago)
by jmduarteg:
Fixed issue: was only considering axes in a, b, c. Now we properly check whether two operators are in same axis, by storing in a HashMap all operator ids per axis. Was affecting some exotic space groups like P 2 3.

1513
(7 years ago)
by jmduarteg:
Implemented some basic symmetry redundancy elimination in interfaces search. Moved interfaces-search to a separate class.
New pymol output file in enumerateInterfaces with all interfaces in a single session

1471
(8 years ago)
by jmduarteg:
Introduced some more experimental code for enumeration of assemblies. BEWARE many things are UNFINISHED, namely in InterfaceGraph class the code to find induced and symmetry related interfaces is just a draft. There are many fundamental issues not solved yet. Be careful especially with implementations of equals and hashCode methods in InterfaceGraph, SubunitId, InterfaceGraphEdge


CHANGE: the main PDB data loading interface has changed. Now all loading of data occurs through PdbAsymUnit. Refactoring of some classes: Pdb is now PdbChain.

1372
(8 years ago)
by jmduarteg:
MAJOR INTERFACE CHANGE: the main PDB data loading interface has changed. Now all loading of data occurs through PdbAsymUnit. Refactoring of some classes: Pdb is now PdbChain.

1372
(8 years ago)
by jmduarteg:
MAJOR INTERFACE CHANGE: the main PDB data loading interface has changed. Now all loading of data occurs through PdbAsymUnit. Refactoring of some classes: Pdb is now PdbChain.

1372
(8 years ago)
by jmduarteg:
MAJOR INTERFACE CHANGE: the main PDB data loading interface has changed. Now all loading of data occurs through PdbAsymUnit. Refactoring of some classes: Pdb is now PdbChain.

1372
(8 years ago)
by jmduarteg:
MAJOR INTERFACE CHANGE: the main PDB data loading interface has changed. Now all loadingOverall survival for the study patients was compared with that of radically treated and supportive care only historical controls. Indices of tumor response were stable or improved in 60% of patients evaluable 1 month postradiotherapy. Median survival for all study patients was 6 months. Median survivals in similar groups of radically treated and supportive care only patients were 10 and 1 month(s), respectively. A survival advantage for the radical vs. short-course treatment was observed for the subset of patients with a pretreatment KPS > 50. Elderly patients with a low pretreatment KPS (< or = 50) may be treated adequately with a short, palliative course of radiotherapy. Elderly patients with a higher pretreatment KPS (> 50), however, may benefit from a higher dose radiotherapy regimen.


on whether China's assistance is productive or not. We hope that certain people in Australia should engage in self-reflection instead of pointing fingers at and making irresponsible remarks on other countries.

Q: According to reports, on January 9, the ROK Foreign Minister Kang Kyung-wha said that the ROK-Japan deal on the comfort women issue cannot really solve the problem. What is your comment?

A: We have taken note of this situation. China's position on the issue of comfort women is consistent and clear-cut. We hope that the Japanese side can take seriously the concerns of its Asian neighbors and the international community and properly handle relevant issue with a responsible attitude. This bears on not only Japan's image but also the historical justice.

Q: It is learned that recently quite aare, what we can do and what we cannot do.

As of Monday, 23 March 2020, all non-virtual meetings of AA in the Lakeshore Intergroup are temporarily closed.

The Intergroup office is also temporarily closed. But groups need to honour their commitments to keep the helpline running! For details about the ongoing phone schedule, see our post.

For a list of locally-created, online AA meetings see our post.Important!! Some groups have experienced security breaches on their Zoom meetings. We have a post that outlines security suggestions. See our post.

For information about global online meetings, online recordings of speakers, and various AA-related apps, see our post.


Efficacy evaluation of a cosmetic slimming treatment for the waist and hips: a double-blind study.
The aim of this study was to evaluate by clinical and noninvasive instrumental evaluations the efficacy and tolerance of a cosmetic topical slimming treatment specific for light/moderate adipose pannicula at the level of the waist and hips. The protocol was performed as a double-blind active vs placebo trial in 110 volunteers for a period of 4 weeks, with an additional visit 4 weeks after the last product application. The following clinical/instrumental evaluation was performed during the visit: clinical assessment of hip-abdomen adipose pannicula, circumference measurements, ultrasonographic evaluation of adipose pannicula thickness, and plicometry. At the end of treatment, the slimming activity of the study product resulted in clinically different results than placebo, determined byI used FRED for the data.

When America was in its growth days and the economy was growing and personal income was growing we had savings rate above 10%. But recently, the savings rate is very low around 2.5 to 5.0%. This is very unfortunate and I think a lot of this is attributed to the growing use of credit to combat the rising costs of living and low to non-existent income growth. Income growth can be seen back in the days before 1980s but in the last few decades there has been little to no income growth across America. America is also driven by a consumer culture and buying large purchases (cars and houses) on large credit. This likely is why Americans have such low savings rate compared


they are based in Ireland. As a result I have some dividends withheld for tax reasons when they pay into my 401k. And since a 401k is a retirement plan, I can never get that withholding back as it's not a taxable account. I forgot about this when I purchased MDT in my 401k (make a reminder, don't purchase foreign dividend paying companies in my 401k).

My 401k only had $2300 in MDT. I sold that and I bought $3200 in Microsoft (MSFT) in my 401k. I still hold over $5000 in MDT in my taxable account and don't plan to change that.Related literature {#sec1}
==================

For the dielectric properties of *N*-protonated compounds, see: Szafranski & Katrusiak (2008[@bb6]); Katrusiak & Szafranski (1999[@bb2]); Chen *et al.* (2009[@bb1]); Mihailovic *et al.* (1990[@bb3]).

Experimental {#sec2}
============

 {#sec2.1}

### Crystal data {#sec2.1.1}

C~6~H~13~N~2~O^+^·C~6~H~2~N~3~O~7~ ^−^*M* *~r~* = 357.29Monoclinic,*a* = 11.521 (2) Å*b* = 19.230 (4) Å*c* = 6.9921 (14) Åβ = 98.73 (3)°*V* = 1531.2 (5) Å^3^*Z* = 4Mo *K*α radiationμ = 0.13 mm^−1^*T* = 293 K0.3 × 0.25 × 0.2 mm

### Data collection {#sec2.1.2}

Rigaku Mercury2 diffractometerAbsorption correction: multi-scan (*CrystalClear*; Rigaku, 2005[@bb4]) *T* ~min~ = 0.176, *T* ~max~ = 0.29815623 measured reflections3495 independent reflections2111 reflections with *I* \> 2σ(*I*)*R* ~int~ = 0.064

### Refinement {#sec2.1.3}

*R*\[*F* ^2^ \> 2σ(*F* ^2^)\] = 0.056*wR*(*F* ^2^) = 0.176*S* = 0.833495 reflections249 parametersH atoms treated by a mixture of independent and constrained refinementΔρ~max~ = 0.18 e Å^−3^Δρ~min~


hydrogen bonds (Table 1) into a three-dimensional network.

Experimental {#experimental}
============

To a solution of triethylenediamine (50 mmol, 5.6 g) in benzene (500 ml) was added rapidly H~2~0~2~ (30%, 6.3 g) with stirring at room temperature. A precipitate formed at once. Water was removed from the reaction mixture by means of P~2~O~5~ drying in a vacuum oven at room temperature. The solid was washed with three 100 ml portions of ether. The crude product (10 mmol, 1.28 g) was dissolved in 10 ml methanol. Then 20 ml of an ethanol solution of picric acid (10 mmol, 2.29 g) was dropped slowly with stirring, and a yellow precipitate formed at once. The suspension was filtered and dissolved in water. After a few weeks, yellow block crystals were obtained by slow evaporation of         Mo *K*α radiation, λ = 0.71073 Å
  Hall symbol: -P 2ybc                    Cell parameters from 5732 reflections
  *a* = 11.521 (2) Å                      θ = 3.8--27.5°
  *b* = 19.230 (4) Å                      µ = 0.13 mm^−1^
  *c* = 6.9921 (14) Å


is that appropriate clinical samples need to be collected at the appropriate time during the disease and should be transported to the laboratory in cold chain in a viral transport medium so as to maintain the viability of the nucleic acid.Multiplex PCR can detect simultaneously other viruses causing a similar clinical picture like the seasonal influenza A and B, respiratory syncytial virus (RSV) and human metapneumovirus.The most preferred specimen is a nasopharyngeal aspirate or a swab preferably within 1--2 days of onset of disease \[[@CR6]\]. Cotton swabs are not recommended due to presence of inhibitors; rayon- or nylon-flocked swabs are used instead. Broncho-alveolar lavage, tracheal aspirates and sputum which contains the highest viral loads are the ideal specimens especially later in the course of illness \[[@CR6]\].RT-PCR tests maybe carried out on serum specimens.In case of suspicion of MERS-CoV or SARS-CoV, stool specimens may also be sent to the laboratory.Many a times these newer molecular assays may not be available even in established diagnostic molecular laboratories and the specimen may have to be shipped under strict biohazard protocols to the national or a regional reference centre for testing.

Other Diagnostic Tests {#Sec6}
----------------------

Rapid diagnostic tests available for the diagnosis of influenza have high specificity but low sensitivity and hence a negative result should be interpreted with care \[[@CR7]\].Though viral cultures don't play a significant role in rapidly diagnosing cases, it is important in confirmation of emerging and re-emerging cases of viral infection, epidemiological typing of isolates and research into vaccines and newer drugs.Clinical signs on examination are minimal


when they become aware of the illegal development occurring."

SUPPLIED A development on the Selwyn Riverbed. A local dairy farmer was served an abatement notice.

A ROAD ON THE SELWYN

Late last year, structures started appearing in the Selwyn River bed.

Among them was a makeshift road about two kilometres long, a long stopbank, land cleared for pasture, and pivot irrigators placed into the ground.

LINZ/SUPPLIED Development on the edge of the Selwyn River. The dots are cows.

After a local complained to ECan – the development was clearly visible from the road – it was traced to nearby dairy farmer Mike Dewhirst, who had allegedly expanded his farm into the riverbed, which is dry for much of the year.

After a complaint, ECan ordered Dewhirst to stop with an abatement notice. It said theICER is above the threshold will lead to a net reduction in health gain to the population. An outcome measure commonly used to make these comparisons is the Quality Adjusted Life Year (QALY), and the threshold in the UK is considered to be in the region of £20,000 - £30,000 per QALY gained \[[@B20]\].

We report a cost-utility and cost-effectiveness analysis of therapeutically reducing blood pressure compared with no therapeutic reduction in blood pressure in hospitalised hypertensive patients with acute cerebral infarction or haemorrhage.

Methods
=======

Full details of the methods and outcome measures in the study are reported elsewhere \[[@B21]-[@B23]\]. The study was designed to include both pressor and depressor trial arms. Due to low recruitment, the pressor arm of the trial was terminated early. We therefore report costs and outcomes


more effective). We estimate a 96.5% probability of the incremental cost per QALY gained being below £30,000 (Table [1](#T1){ref-type="table"} Analysis 6), indeed irrespective of the threshold, the probability that treatment is cost-effective never falls below 92%.

The above figures are based on complete case analysis. That is, observations were included in analyses 1-6 only where complete cost and outcome data were available (see Figure [1](#F1){ref-type="fig"}). We had complete survival data on all 171 patients at three months. However, we were only able to measure mRS and hence QALYs gained on 32 patients at 3 months. Therefore the estimate of incremental cost reported above does not include all observations for which cost data were available. Looking just at resource use data (and hence based on n = 105 active +added to this may risk double counting if the unit cost used factors in an allowance for drugs. This is an issue common to many economic evaluations, and care must be taken to be sure of what is included in \'per episode\' unit costs. In the context of this study, as drug costs were such a trivial component, the impact on the results would be negligible.

We did not document readmissions within this study. However, for this to affect the conclusion of the study, we estimate that patients in the treatment arm would on average, need 2.3 to 2.5 additional readmissions per patient over the three months compared with placebo. We consider such a large difference to be unlikely, indeed a priori it may be expected for there to


of ten Democrats voted for Obama, near the high end of the level of party support we've seen in recent elections. I'm fairly certain the same thing will happen this year.

Bernie Sanders is what we sometimes call a "conviction" candidate, someone spurred to run for president not by simple ambition (though make no mistake, there's plenty of that) but because of a firm, unshakeable belief in a set of principles. Barry Goldwater was a conviction candidate, Richard Nixon was not; George McGovern was a conviction candidate, Al Gore was not. And when you're a conviction candidate, you can attract a particularly passionate kind of supporter, one who believes that an uncompromising ideological crusade is exactly what will produce necessary change.

Hillary Clinton is about as far from a convictioncandidate as you can get. That isn't to say she doesn't have convictions, but she obviously sees conviction and policy as not quite the same things-policy is your best effort to put your convictions into practice, but it comes with the realization that pragmatic compromises may have to be made.

It's been noted about Sanders that he believes exactly the same things that he did when he first got involved in politics half a century ago, and that certainly isn't true of Clinton. She has moved and evolved, and more than anything else, she has changed as her party has changed. In the 1990s, she and her husband were at the vanguard of a movement that sought to bring a more centrist cast to the Democratic Party after three


arachidonic (C20:4) forms ([@bib2]). Functionally, PIP~2~ directly regulates a variety of ion channels with a diverse range of affinities, typically by binding to positively charged regions of the proteins located near the membrane ([@bib11]; [@bib35]; [@bib13]). In many channels, the binding of PIP~2~ acts to maintain their functionalities; this is well illustrated in so-called "rundown" phenomena often caused by depletion of PIP~2~, in which PIP~2~ essentially acts as a functionally necessary cofactor ([@bib2]). More complex modulatory phenomena by PIP~2~ have been also reported. For example, CNG channels in rod photoreceptors are inhibited by PIP~2~, whereas CNG channels in olfactory receptors are PIP~2~ insensitive ([@bib42]). Furthermore, PIP~2~ may exert both excitatory and inhibitory influences in the same channels through multiple interaction sites, as shown in capsaicin-sensitive TRPV1 and hyperpolarization-activatedpanel, currents before (blue) and after (red) the application of 10 µM PIP~2~ to the cytoplasmic side recorded without Ca^2+^ are shown. Pulses were applied from 0 mV every 3 s except for Slo1 + β2, which was stimulated every 10 s. For Slo1 + β2, 1-s prepulses to −100 mV preceded depolarization pulses. For Slo1 + LRRC26 (γ1), the holding voltage was −80 mV. (B) Fractional changes in peak outward currents in Slo1, Slo1 + β1, Slo1 + β2, Slo1 + β2 Δ2--19, Slo1 + β4, and Slo1 + LRRC26 (γ1). (C) Normalized conductance (G-V) curves before (blue) and after (red) the application of 10 µM PIP~2~ in the channels indicated. The smooth curves are Boltzmann fits to the results with: Slo1, V~0.5~ = 154.5 ± 3.1


high affinity divalent cation sensors of the channel ([@bib15]), PIP~2~ enhanced currents through Slo1 D362A:D367A:E399A:Δ894--895 ([Fig. 4 D](#fig4){ref-type="fig"}; ΔV~0.5~ = −25.6 ± 3.7 mV \[5\]) and those through wild-type Slo1 ([Fig. 4 E](#fig4){ref-type="fig"}; ΔV~0.5~ = −22.2 ± 3.7 mV \[7\]) by shifting V~0.5~ to the negative direction. The measurements manipulating the concentration of Ca^2+^ showed that the crossover from the stimulatory effect (ΔV~0.5~ of \<0) to the inhibitory effect (ΔV~0.5~ of \>0) of PIP~2~ occurs around a few micromolars of \[Ca^2+^\] ([Fig. 4, F and G](#fig4){ref-type="fig"}). The effectiveness of PIP~2~ with 100 µM Ca^2+^ also indicates that the stimulatory action of PIP~2~ does not require modulation of the high affinity Ca^2+^ sensor activation. When β1 was coexpressed, a robust stimulatory effect of PIP~2~ clearly persisted with 10 mMpotentially interact with the negatively charged head group of PIP~2~. Neutralization of the positively charged residues in β2 Δ2--19 (β2 Δ2--19 K24N:R26N:H28N) did not confer a greater shift of V~0.5~ by PIP~2~ to Slo1 + β2 Δ2--19 ([Fig. 5 B](#fig5){ref-type="fig"}). However, neutralization of the negatively charged residues (β2 Δ2--19 D27Q:D29Q:D32Q) significantly increased ΔV~0.5~ by PIP~2~ to −18.6 ± 1.0 mV (8) (P = 0.00017; [Fig. 5 B](#fig5){ref-type="fig"}), indicating that there may be an electrostatic repulsion between these negatively charged residues and the PIP~2~ head group. The PIP~2~-induced ΔV~0.5~ in Slo1 + β2 Δ2--19 K24N:R26N:D27Q:H28N:D29Q:D32Q, in which both the positively charged residues and negatively charged residues are neutralized, was indistinguishable from that in Slo1 + β2 Δ2--19 D27Q:D29Q:D32Q (P = 0.53; [Fig. 5 B](#fig5){ref-type="fig"}).

![Critical role of the β N


observed in both Slo1 and Slo1 + β1, and most probably in all others, is to bias the equilibrium of the ion conduction gate, L~0~ in the HA model ([@bib15]), toward the open state. Such a change shifts V~0.5~ to the negative direction as observed in Slo1 + β1, Slo1 + β2 Δ2--32, and Slo1 + β4. This increase in L~0~ is probably mediated by the binding of PIP~2~ to the sequence ^329^RKK^331^ immediately C terminal to S6 because the Slo1 mutation R329A:K330A:K331A ([@bib38]) appears to disrupt the stimulatory effect of PIP~2~ on Slo1 + β1. It should be noted, however, that the mutation itself without any exogenous PIP~2~ strikingly shifts the voltage dependence of activation to the negative direction, and some interpretational uncertainty exists. The interaction betweenall the powers of the state: police, prison and the heavy hand of criminal law.

Just as Brexit is Britain’s “drama of departure,” as Fintan O’Toole noted in the Guardian, this trial marks the climax of Spain’s drama of forced inclusion. Both dramas are replete with unintended ironies and self-defeating nationalism — to demand Catalonia’s inclusion in the name of a strong, unitary Spain by keeping its political and civic leaders in pretrial detention for a year and threatening decades of imprisonment seems destined to be counterproductive. On the other hand, it can’t be right that the Catalan independence referendum was “just” a democratic exercise, political speech or a gambit to force Spain to renegotiate Catalonia’s statute of autonomy, as defenders often insist. It may have been all those


                        fromY = toY = Math.floor(height / 2);
                            toX = Math.floor(width * 1 / 4 + width * dragStartPct * 3 / 4);
                            fromX = Math.floor(width * 3 / 4 + width * dragStartPct * 1 / 4);
             coach if they want to watch their TV show uninterrupted.

Designed to raise awareness of the importance of staying active and moving regularly, the PTV service will initially be introduced at David Lloyd Chigwell. Depending on the success of the trial, DLL will roll out the service across the UK in the coming months.

"We are always looking at ways we can introduce exciting new types of classes and services that can really benefit our members," said Jorge Fernandes, GM at David Lloyd Chigwell.

"We appreciate that the hectic nature of modern life means people often struggle to find time to exercise each week.

"Our new PTV classes aim to counter this trend, giving time-poor parents and young professionals the perfect means to stay up to date with their favourite shows while


of the state and trying to sample as many hikes as possible, because I know I left a lot of good stuff out. I tried for a representational mix of easy and difficult hikes that cover as much of the state as possible. I also tried to include any places with compelling natural or human history connections. I selected hikes based on personal experience and recommendations from friends and other hiking guides.

Question: Have you tried them all?

Answer: I had to hike at least part of all the hikes, because each hike contains multiple GPS coordinates that can only be obtained by going there. There were a few hikes where I drove between some of the waypoints due to time constraints, but the inclusion of the GPS coordinates isarticulation. In his letter to the editor, published in The Journal of the Acoustical Society of America, he described a setup using two sensor coils and one generator coil. The sensor coils, attached to the forehead and back of the neck, would remain stationary while the generator coil, attached to the jaw, would move creating variable currents in the sensor coils. These currents could then be used to determine the distance in two dimensions.

Early EMA systems like Hixon's had problems with accounting for tilting of the tongue during use as tilting of the sensor coils causes changes in the induced current that can skew data. In 1987, Paul Schönle et al. published an improved system that used three transmitter coils (analogous to Hixon's generator coil) and computer software


malfunctioning during swallowing, and positions in which swallowing is easiest. Only limited data is able to be collected as sessions are typically limited to three minutes due to the hazards of radiation exposure. and it does not allow for fine grain analysis of tongue movements.

X-ray microbeam
Similar to video fluoroscopy, X-ray microbeam studies use radiation to study movements of articulators. Gold pellets, 2 to 3 mm in size, are placed in and around the mouth similar to the coils used in EMA. Radiation exposure is limited by using computer software to focus narrow x-ray beams, about 6mm2, on the pellets and track them as they move. Like EMA, x-ray microbeam studies are limited by the placement of the pellets. While able to minimize radiation exposure, the system is largely inaccessibleNeurofeedback therapy for alcohol use disorder.
Neurofeedback is a therapeutic learning process that provides visual and auditory feedback to an individual about his or her brainwaves in order to teach self-regulation of brain func- tion. Currently, neurofeedback therapy has been attempted to apply to various psychiatric disorders and certain therapeutic effects have been shown. The advantage of incorporating neurofeedback therapy to the conventional treatments is 1) the action on the central nervous-system can be expected. by directly reinforcing EEG, 2) on the premise of neural plasticity, without ongoing intervention, long-term therapeutic effect can be expected, 3) except rare temporary headache, no significant side effects are reported, 4) compared to other psychotherapies, neurofeedback is expected to have a therapeutic effect within a relatively short period of time. The present paper