     }
    }
  }
  EXPECT_EQ(param_methods.size(), 2);

  std::vector<Pass*> passes = {
      new InstructionSequenceOutliner(),
  };

  run_passes(passes);

  std::vector<DexMethod*> outlined_methods;
  for (auto m : param_methods) {
    cfg::ScopedCFG scoped_cfg(m->get_code());
    auto outlined_method = find_invoked_method(*scoped_cfg, "$outline");
    EXPECT_NE(outlined_method, nullptr);
    EXPECT_EQ(count_invokes(*scoped_cfg, outlined_method), 1);
    outlined_methods.push_back(outlined_method->as_def());
  }
  sort_unique(outlined_methods);
  EXPECT_EQ(outlined_methods.size(), 1);
  for (auto m : outlined_methods) {
    EXPECT_TRUE(is_static(m));
    auto proto = m->get_proto();
    EXPECT_EQ(proto->get_rtype(), type::_int());
    EXPECT_EQ(proto->get_args()->size(), 1);
    EXPECT_EQ(proto->get_args()->at(0), type::_int());
  }
}

TEST_F(InstructionSequenceOutlinerTest, defined_reg_escapes_to_catch) {
  // We cannot outline when a defined register escapes to a throw block
 std::vector<DexMethod*> defined_reg_escapes_to_catch_methods;
  for (const auto& cls : *classes) {
    for (const auto& m : cls->get_vmethods()) {
      if (m->get_name()->str() == "defined_reg_escapes_to_catch") {
        defined_reg_escapes_to_catch_methods.push_back(m);
      }
    }
  }
  EXPECT_EQ(defined_reg_escapes_to_catch_methods.size(), 1);

  std::vector<Pass*> passes = {
      new InstructionSequenceOutliner(),
  };

  run_passes(passes);

  for (auto m : defined_reg_escapes_to_catch_methods) {
    cfg::ScopedCFG scoped_cfg(m->get_code());
    auto outlined_method = find_invoked_method(*scoped_cfg, "$outline");
    EXPECT_EQ(outlined_method, nullptr);
  }
}

TEST_F(InstructionSequenceOutlinerTest, big_block_can_end_with_no_tries) {
  // Test that a sequence becomes beneficial to outline because a big block can
  // have throwing code followed by non-throwing code.
  std::vector<DexMethod*> big_block_can_end_with_no_tries_methods;
  DexMethodRef* println_method;


Twin Lake Special

Also known as the Thin Mint

This is an absolutely killer version of the woolly bugger. The bead head gives it great action, and the color combination is irresistible to trout and bass. One of my favorite lake flies; it is usually the first (and sometimes the only) fly that I use in most lake scenarios.Q:

Unable to create data driven subscription for ssrs report

I have a SSRS report which displays daily status report for the team members. The dataset of the report depends on User!UserID as a parameter which is passed to the SQL Query to fetch the data. I want to create a data driven subscription on this report so that every user gets his/her daily status report each morning. But when I click on the "New Data-Driven Subscription" I get a message "Data-driven subscriptions cannot be created because the credentials used to run the report are not stored, the report is using user-defined parameter values, or if a linked report, the link is no longer valid."
One of the solutions to the above issue is provided at  http://social.msdn.microsoft.com/Forums/en/sqlreportingservices/thread/94ad2583-4591-4d28-add3-629b9565c27d. The post says


sz;
		_bufferIndex = 0;
		sz = _bufferSize;
	}
	if( size )
	{
		memcpy( _buffer+_bufferIndex , _data , size );
		_bufferIndex += size;
	}
	return true;
}
bool BufferedReadWriteFile::read( void* data , size_t size )
{
	if( !size ) return true;
	char *_data = (char*) data;
	size_t sz = _bufferSize - _bufferIndex;
	while( sz<=size )
	{
		if( size && !_bufferSize ) return false;
		memcpy( _data , _buffer+_bufferIndex , sz );
		_bufferSize = fread( _buffer , 1 , _bufferSize , _fp );
		_data += sz;
		size -= sz;
		_bufferIndex = 0;
		if( !size ) return true;
		sz = _bufferSize;
	}
	if( size )
	{
		if( !_bufferSize ) return false;
		memcpy( _data , _buffer+_bufferIndex , size );
		_bufferIndex += size;
	}
	return true;
}}
})

defineClass('JSSuperTestA1: JSSuperTestA', {
    method: function(){
        return self.super().method() + '1'
    }
})

defineClass('JSSuperTestA2: JSSuperTestA1', {
    method: function(){
        return self.super().method() + '2'
    }
})

defineJSClass('JSClassA', {
    init: function() {
        this.prop1 = 'A'
        return this
    },
    method: function() {
        return this.prop1
    }
}, {
    clsMethod: function() {
        return '1'
    }
})

defineJSClass('JSClassA1: JSClassA', {
    method: function() {


of global_state field (jdapi.c has some dependencies on ordering!) */
#define CSTATE_START	100	/* after create_compress */
#define CSTATE_SCANNING	101	/* start_compress done, write_scanlines OK */
#define CSTATE_RAW_OK	102	/* start_compress done, write_raw_data OK */
#define CSTATE_WRCOEFS	103	/* jpeg_write_coefficients done */
#define DSTATE_START	200	/* after create_decompress */
#define DSTATE_INHEADER	201	/* reading header markers, no SOS yet */
#define DSTATE_READY	202	/* found SOS, ready for start_decompress */
#define DSTATE_PRELOAD	203	/* reading multiscan file in start_decompress*/
#define DSTATE_PRESCAN	204	/* performing dummy pass for 2-pass quant */
#define DSTATE_SCANNING	205	/* start_decompress done, read_scanlines OK */
#define DSTATE_RAW_OK	206	/* start_decompress done, read_raw_data OK */
#define DSTATE_BUFIMAGE	207	/* expecting jpeg_start_output */
#define DSTATE_BUFPOST	208	/* looking for SOS/EOI in jpeg_finish_output */
#define DSTATE_RDCOEFS	209	/* reading file in jpeg_read_coefficients */
#define DSTATE_STOPPING	210	/* looking for EOI in jpeg_finish_decompress */

/* Declarations for compression modules */

/* Master control module */
struct jpeg_comp_master {
  JMETHOD(void, prepare_for_pass, (j_compress_ptr cinfo));
  JMETHOD(void, pass_startup, (j_compress_ptr cinfo));
  JMETHOD(void, finish_pass, (j_compress_ptr cinfo));

  /* State          huffman_index *index));

  int current_sos_marker_position;
#endif
};

/* Entropy decoding */
struct jpeg_entropy_decoder {
  JMETHOD(void, start_pass, (j_decompress_ptr cinfo));
  JMETHOD(boolean, decode_mcu, (j_decompress_ptr cinfo,
				JBLOCKROW *MCU_data));

  /* This is here to share code between baseline and progressive decoders; */
  /* other modules probably should not use it */
  boolean insufficient_data;	/* set TRUE after emitting warning */

#ifdef ANDROID
  JMETHOD(boolean, decode_mcu_discard_coef, (j_decompress_ptr cinfo));
  JMETHOD(void, configure_huffman_decoder, (j_decompress_ptr cinfo,
                    huffman_offset_data offset));
  JMETHOD(void, get_huffman_decoder_configuration, (j_decompress_ptr cinfo,
                    huffman_offset_data *offset));

  huffman_index *index;
#endif
};

/* Inverse DCT


ITHACA TIMES, Vol. XXIV No. 19, 12/12/01 p. 14
 Minton, David, "Poet’s art about ‘play, ambiguity’", LEXINGTON HERALD LEADER, 1/11/1998
 "Exhibition of Korean and American Women Artists," Modern Art Gallery, Exhibition Catalog, July, 1989
 THE ARTFUL HOME, The Guild Sourcebook  of Residential Art,  Edition 3, GUILD Sourcebooks, Madison, WI, 2005, p. 197
 "A Soothing Place to Work,"  DESIGN JOURNAL MAGAZINE, Fall, 2007, p. 75
 Fenson, Mel, "Abstract Art," COLORADO MAGAZINE ONLINE,  2007

External links
 Lynne Taetzsch biography
 Colorado Magazine Online article
 Clinical Psychiatry News article
 Monkdogz.com

Category:1941 births
Category:Living people
Category:People from East Orange, New Jerseyexperimentalists can discover or exclude it by looking at a specific place, instead of measuring zero more and more accurately, like in the electron experiments."

In the meantime, the physicists are also looking forward to improved measurements of the muon anomalous magnetic moment—if the discrepancy remains, the results will offer further support for the existence of the new particle. The scientists also plan to apply some of the methods they developed here to look for other new particles.

"Our work on this has allowed us to develop new theoretical tools to aid in the search for other kinds of bosons with different quantum numbers," Miller said. "We will be applying those tools. Another direction is to develop a deeper theory that accommodates our new boson."

Explore further New measurement with deuterium


as detailed in the following. AGT, prorenin, renin, and aldosterone are the four hormones and enzymes synthesized in cells and then secreted endocrinally. It was assumed that these hormones and enzymes are produced intracellular and secreted into the plasma by a first order rate (*r*~2~ in μmol· min^−1^) proportional to the intracellular concentration (*C*~CellularHormone~) in the respective organ with the rate constant *k*~Secretion~ (in L· min^−1^). The renin secretion *r*~3~ (μmol· min^−1^) is described by a "competitive" inhibition equation including the conversion of prorenin to renin influenced by Ang2 (see Figure [1](#F1){ref-type="fig"}), describing the conversion from prorenin to renin, and simultaneously describing the secretion from intracellular to plasma compartment of the kidney: $$r_{3} = \frac{V_{\text{MaxKid}} \cdot V_{\text{Kidney}} \cdot C_{\text{Prorenin}}\left( t \right)}{C_{\text{Prorenin}}\left( t \right) + K_{\text{mKid}} \cdot \left( {1 + \left( \frac{C_{\text{Ang2}{(t)}}}{K_{\text{inhibition}}}\right)} \right)}$$ *K*~mKid~ and *V*~MaxKid~ are the respective enzymatic activity constants, *V*~kidney~ is the intracellular volume of the kidney, *C*~Prorenin~ is the renal intracellular prorenin concentration (parameters under prorenin in Table [1](#T1){ref-type="table"}). *K*~inhibition~ represents the inhibitory constant for Ang2 and *C*~Ang2~ is the renal plasma concentration of Ang2. The degradation rate *r*~4~ (μmol· min^−1^· L^−1^) is described by Guillaud and Hannaert ([@B23]): $$r_{4} = C\left( t \right) \cdot \left( \frac{\ln 2}{t_{1/2}} \right)$$ *t*~1/2~ determines the half-life and *C*(*t*) being the respective plasma concentration over time. These half-lives were optimized for the hormones and enzymes (see Table [1](#T1){ref-type="table"}). The conversion of AGT to Ang1 and from Ang1 to Ang2 take place in the plasma compartments of all organs (Eissing et al., [@B18]) and is an enzymatically regulated process described by a


(*C*~Ref~, see Table [3](#T3){ref-type="table"}) times the percentage of reference expression (*E*~Ref~) from literature (see Table [4](#T4){ref-type="table"}, factor *E*~Ref~ = 100 for the highest expression value): $$C_{0} = C_{\text{Ref}} \cdot \frac{E_{\text{Ref}}}{100}$$ Ang2 binds to the AT1 receptor, which influences the aldosterone secretion. AT1 binding rate (*r*~7~ in μmol· min^−1^· L^−1^) is described by a typical equation with *k*^+^ and *k*^−^ binding constants for association and dissociation and the respective concentrations for AT1 (*C*~0~), Ang2 (*C*~2~), and the AT1-Ang2 complex (*C*~Complex~): $$r_{7} = \left( {k_{+} \cdot C_{0} \cdot \left( t \right) \cdot C_{2}\left( t \right)} \right) - \left( {k\text{\_} \cdot C_{\text{complex}}\left( t \right)} \right)$$

The AT1 concentrations were calculated as explained in Eq. [6](#E6){ref-type="disp-formula"}, the respective relative expression values (*E*~Ref~) are shown in Table [4](#T4){ref-type="table"}, and the reference concentration (*C*~Ref~) is presented in Table [1](#T1){ref-type="table"}.               1.57                  1.35                                  1.49                    1.42

*\*Two enalapril maleate capsules were administered at the same time, containing 5 mg enalapril each*.

*^†^*V*~maxLiv~ values for carboxylesterase enzyme and the conversion from Ena to Enaat in Eq. [8](#E8){ref-type="disp-formula"}*.

The respective parameters for Michaelis--Menten kinetics are *V*~MaxLiv~ and *K*~mLiv~.

Assembling of the models to


                                                       0 (0)

Results
=======

Oral administration of enalapril
--------------------------------

A PBPK model of IV Enaat has been developed with the data indicated in Table [2](#T2){ref-type="table"}. In Figure [2](#F2){ref-type="fig"} the resulting PK-simulations for IV Enaat are shown and the goodness-of-fit of the model based on data is depicted (Hockings et al., [@B25]). This model was used to determine the parameters related to Enaat, which are log *P*, Molecular weight, pKa, plasma protein binding and clearance (see Table [2](#T2){ref-type="table"}). Additionallyet al. ([@B22]), Lu et al. ([@B37]). The solid black regression line denotes the line of identity (observed outcome is equal to simulated outcome).](fphys-04-00004-g003){#F3}

RAAS inhibition by enalaprilat
------------------------------

The PBPK model for the circulating, endocrine RAAS was developed to describe the steady state described in literature. It corresponds to the pre-administration steady state discussed further in the following. The model for Ena was then coupled to the RAAS model to explore the dynamical behavior of the system under inhibition. In Figure [4](#F4){ref-type="fig"} the results for the full RAAS model under administration of 10 mg Ena are shown at *t* = 1500 min (administration at *t* = 1500 indicated by the red arrow). All parameters of the Ena-Enaat model were used without changes. The pre- and post-administration steady states as well as the dynamical transition after administration


to explore pharmacodynamic effects in the same model framework. Further extensions of this model and an inclusion of the dynamic behavior of the blood pressure in response to changes in RAAS would allow a full mechanistic representation of the PBPK-PD relationship in cardiovascular diseases. Such a model could thus rationalize treatment decisions in the area of cardiovascular diseases. By inclusion of a full process description from administration of a drug to its effect, i.e., the lowering of blood pressure, such a model allows to support cardiovascular drug research from target identification and validation to dosing regimen decision.

Conflict of Interest Statement
==============================

Karina Claassen is funded by and Thomas Eissing, Michael Block, and Stefan Willmann are employes of Bayer Technology Services GmbH, the company that owns and commercializes the software platform    .result:hover,
        .result:focus {
          background-color: var(
            --site-search-result-background-color-hover,
            #dddddd
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          color: var(--site-search-link-color-hover, #000000);
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          outline: 2px solid grey;
          outline-offset: 4px;
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        .result .title {


         ${item.title}<span
                ?hidden="${!this.showPath}"
                class="link-text"
                aria-hidden="true"
                >(${item.location})</span
              >
            </div>
            <div class="date" ?hidden="${!this.showDate}">
              <simple-datetimeby the statutory maximum imprisonment sentence), cert. denied, 495 U.S. 934 (1990).  We agree with the reasoning of the Jamison and Montenegro-Rojo courts, and with the result reached by all of these courts, and find no merit in Yost's contention.

IV.

14
Yost makes three other assignments of error to the district court's determination of his period of imprisonment.  All are without merit.

15
Yost argues first that the district court erred in finding that he was a ringleader of a conspiracy and, as a result, enhancing by four his offense level under U.S.S.G. § 3B1.1(a).  We review the district court's finding under the "clearly erroneous" standard.   United States v. Fells, 920 F.2d 1179, 1182-83 (4th Cir. 1990), cert. denied, 111 S. Ct. 2831 (1991).

16
Three other defendants pled


guilty to the same drug charges as Yost.  In addition, seven other people were listed in the pre-sentence report as related cases.  Officer Bucher, the government's summary witness, testified that Yost had been the source of drugs for many of these people.  The district court judge stated that Bucher's testimony was "entirely consistent with ... [the] testimony from quite a number of defendants ... that Yost was the ringleader and the source."  In addition, David White, one of Yost's co-defendant's, corroborated Bucher's testimony that Yost was the source for at least some of the people involved in related cases.  In light of all of this evidence, the district court's finding that Yost was a ringleader was not clearly erroneous.

17
Second, Yost argues that theon the subscribers' current FiOS TV
package. The app also offers access to more than 20,000
movie and TV show titles available monthly through FiOS
TV?s Flex View, which offers FiOS customers the ability to
buy or rent these titles and watch them on the TV, PC or
mobile device and now compatible Samsung devices.

The FiOS TV application has parent friendly features such
as parental PIN options to restrict mature content as well
as a purchase PIN requirement for authorization of any
rental and purchases of On Demand content through the
application. The application also offers traditional
features such as closed captioning, help and FAQs.

To download the FiOS TV App, go to the "Smart Hub" on
eligible Samsung devices.


Indoor Recreation Facilities > Membership Information

Recreation Center Membership

Our recreation centers are more than just indoor gyms! Join a recreation center and become part of a community of New Yorkers who support each other. With a membership, you can get fit, learn new skills, develop your hobbies, and make friends.

As of Tuesday, March 17, for the safety of our patrons, all recreation centers are closed to the public until further notice. We will be extending all memberships to our recreation center members to cover the length of time we are closed.

Recreation Center Locations

To find a recreation center in your area, visit our recreation center locations page.

Membership Benefits

Become a member, and get access to hundreds of different programs, facilities, and activities, including:

Adaptive Programs

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GameWednesday, October 19, 2011

These are quotes from various people in regards to an article in 2006 that was written about the Canadian Mission in Afghanistan.

I have left out the names for their own anonymity.

I have also included pictures of what its like on the ground..... the true reality of the situation.

I do find it amazing that on calls for human rights, women's rights, children's rights they simply say that Afghanistan is not worth it...

I would argue it is.

I would also put my life out there to make it happen and I did as did 40 000 other Canadians soldiers sailors and aircrew.

Afghanistan: Wrong Mission for Canada

http://thetyee.ca/Views/2006/10/06/Afghanistan/

(I left the spelling and grammar as is...)

"There are a lot of people in the military who want it to be all about


simply be there for a few years throwing young men and women into their graves in the aid of a cause our leaders. Our reasons for going to war there will be forgotten by those who we are trying to please, and with the expection of a few Afghanis whose lives may have been spared by Canadian soldiers, our legacy in that country will be moot."

"The war, however, is futile and useless. No foreign power has ever managed to install a government of its choice in a country that is largely, and always has been, lawless."

"We need them at home, perhaps even forming an armed "Marines" unit, or Ranger force, to defend our north,, and back up a sea presence there against the US who is challenging ourof material that is thrown out around the crater rim as a result of a meteoritic or volcanic impact – said it was formed a mere 12,000 years ago.

Slow decline

However, both the crater and the lake have been subject to degradation over the years. Lonar town almost directly abuts the crater and there are some slums along the northern part of the crater rim that are now being removed.

Even the water quality has been affected. A report in downtoearth.org from 2011 said that sewage from human habitation had made its way into the lake, reducing its salinity. The report said:

“The lake… has been reduced into a waste receptacle for the past several decades despite the local council declaring a 500 metre zone surrounding the lake as a no-development


levels has triggered algae growth, blocking oxygen necessary for the survival of the lake’s unique population of magnetic and methane-eating bacteria.”

In 2002, the Supreme Court asked the Centre to demarcate a 10 km protective radius around all eco-sensitive zones in the country, Prabhune said. But when the states said this was not practical, the Centre decided in 2006 that these zones would be site-specific.

The wheels of government move slowly, so listing these zones only began in 2010 and are expected to be finalised this year. Local bodies, such as the municipal corporation at Lonar, created their notifications, which were approved by state governments and then passed on to the Centre. Bugdane's conservation panel was not involved in this process.

In 1999, it was the district administration in Buldhana thatreservosome formation.

Cargo-containing vesicles bud from the TGN to different destinations by a regulated process that envolves the assembly of specific cytosolic cargo adaptors onto TGN membranes \[[@pone.0179615.ref019],[@pone.0179615.ref020]\]. Cargo adaptors recognize an appropriate sorting signal in the cytosolic domain of cargo molecules and pack them, aided by auxiliary proteins, into vesicles that are delivered to their target sites at the endocytic or secretory pathways \[[@pone.0179615.ref021]\]. Eukaryotic cells have different cargo adaptors, including cytosolic proteins from the family of heterotetrameric adaptor complexes (APs) \[[@pone.0179615.ref022]\]. All five AP complexes identified to date (AP-1 to AP-5) consist of two large subunits of \~100 kDa (β1- β5, and either α, γ, δ, ε or ζ), a medium subunit of \~50 kDa (μ1--μ5) and one small subunit of \~20 kDa (σ1--σ5) \[[@pone.0179615.ref022],[@pone.0179615.ref023]\].

The AP-1, AP3


ID TcCLB.508257.260, from tritrypdb.org) were amplified by PCR using the primers HingeF and HingeR ([Table 1](#pone.0179615.t001){ref-type="table"}), which contain the *attB*1 and *attB*2 recombination sites, respectively. These sites allowed the insertion of the PCR fragment into the pDONR 221 vector from the Gateway recombination cloning system (Thermo Scientific, MA, USA). The resulting recombinant plasmid (entry clone) was then used to transfer the hinge fragment DNA cassette (by recombination) into the expression vector pDEST17 from the Gateway platform. *Escherichia coli* strain BL21(DE3)STAR was used to produce the histidine-tagged TcAP1-γ hinge domain by induction with 1 mM IPTG. Inclusion bodies containing the insoluble recombinant protein were purified as previously described \[[@pone.0179615.ref037]\] and then solubilized in Laemmli sample buffer (60 mM Tris-HCl, pH 6.8, 10% glycerol, 2% SDS, 5% 2-mercaptoethanol and 0.01%5μm

(TIF)

######

Click here for additional data file.

###### Effect of *Trypanosoma cruzi* AP-1gamma subunit (TcAP1-γ) gene knockout on cruzipain localization in amastigote surface.

Wild-type (WT) and AP-1 γ null mutant (γKO) amastigote (not permeabilized) were labelled with anti-cruzipain antiserum and, detected with anti-mouse IgG conjugated to Alexa Fluor 594. A strong labelling was localized in the WT surface (A), whereas the γKO amastigote surface was faintly labelled (B). Nuclear (n) and kinetoplast (k) DNA were stained with Hoechst 33342. DIC, differential interference contrast microscopy. Scale bar = 5μm

(TIF)

######

Click here for additional data file.

###### Ultrastructural analysis of *T*. *cruzi* epimastigote forms from wild-type (WT) and TcAP1-γ knockout (TcγKO) parasites.

The Golgi complex (arrow) is observed at the anterior region of both WT (**a**) and TcγKO (**b**) parasites. No noticeable morphological alteration


Winfield’s Madi Moore, left, started the Friends of Lilly Foundation for her sister, Lilly, right, who has epilepsy. They are training their dog, Oliver, to be Lilly’s service dog.

Submitted photo

By Becky HopfSpecial to The Tuscaloosa News

Published: Tuesday, September 3, 2013 at 9:00 p.m.

Last Modified: Tuesday, September 3, 2013 at 11:42 p.m.

There are days when Lilly Moore feels ostracized, like she just doesn’t fit in.

“There are all these cliques at school, and it’s hard to make friends,” the 13-year-old Lilly said. “I’ve had trouble in the past where I’ve made friends, and then I have a seizure, and they just quit.”

Lilly has epilepsy. She has seizures almost daily, though mostly they are minor and brief in duration. She likens it to completely zoning out, lapsing into moments when shephone call gave Madi the answer.

Shortly after, she and Courtney filed the necessary paperwork required to establish a nonprofit, and the Friends of Lilly Foundation, “Changing the Stigma of Epilepsy One Friend at a Time,” was founded.

“It’s still a work in progress because of how busy we were with softball this summer and now school has started back,” said Madi, 16 and a junior who has verbally committed to play at Alabama. “Our main thing right now is to raise awareness, to say epilepsy is not all that bad, because look at my sister: She has it and she’s doing all these amazing things. She’s very active. She’s smart. We’re trying to show that people living with epilepsy can live normal lives, just like everybody else.”

Lilly is the


said. “It’s amazing to me that as Madi is competing and going through the things she needs to do to fulfill her dream of playing college softball, she’s also looking out for her sister. It’s so important that this knowledge gets out, and they’re the perfect messengers. They’re great people.”

In April, Lilly and Meredith Moore traveled to Washington, D.C., to participate in the National Epilepsy Walk. They did it in honor of Lilly’s “Seizure-versary,” marking 10 years since her first seizure. Meredith Moore has family and friends nearby, 17 of whom joined in the walk. She saw Lilly blossom there before her very eyes.

“I met people who go through what I go through,” Lilly said. “It made me feel like I wasn’t the only one out there.”

Lilly also<- c(9, 9, 9)

desired result:
abcd_end <- data.frame(id, a, b, c, d, ab, cd)

A:

We don't need to quote
lst1 <- mget(DMcomponents)

 for (nm in names(lst1)){
    abcd[nm] <- rowMeans(abcd[lst1[[nm]]])
  }

abcd
#  id a b c  d ab cd
#1  1 4 6 8 10  5  9
#2  2 4 6 8 10  5  9
#3  3 4 6 8 10  5  9

data
id <- c(1, 2, 3)
a <- c(4, 4, 4)
b <- c(6, 6, 6)
c <- c(8, 8, 8)
d <- c(10, 10, 10)

abcd <- data.frame(id, a, b, c, d)
DMcomponents <- c("ab", "cd")
ab <- c("a", "b")
cd <- c("c", "d")


glutamate concentrations resulting in excitotoxicity, causing necrosis of the adjacent parenchyma, which creates space permitting proliferation. \[[@R7], [@R8]\] Additionally, cysteine uptake provides a precursor for the formation of glutathione, which is protective against endogenous reactive oxygen species and further promotes glioma growth. \[[@R7]\] Furthermore, deranged glutamate transport has been associated with the pathogenesis of glial tumour associated epilepsy (TAE). \[[@R9], [@R10]\]

PPARγ is a ligand-dependent transcription factor that responds to both physiological and chemical stimuli, including the cyclopentatone prostaglandin, 15-deoxyΔ^12,\ 14^ prostaglandin J~2~ (15d-PGJ~2~) and thiazolidinediones (TDZ) respectively. \[[@R11]\] Expression of PPARγ in the brain has been found in multiple cell types including microglia, astrocytes, oligodendrocytes, and neurons. It has been shown in rat cortical cultures incubated with the commercially available PPARγ agonist rosiglitazone, that this drug increases thea cytostatic agent **(b, d, f** & **h)** Bars show means with SEM, ns refers to non-significance. Student *t* test, *n* = 3 (a--d). All results were non-significant, *p* value \> 0.05.](oncotarget-06-21301-g006){#F6}

Pioglitazone reduces extracellular glutamate release from glioma cells {#s2_6}
----------------------------------------------------------------------

In order to elucidate whether glutamate uptake in glioma cells is increased by any potential reduction in glutamate transporters, we measured glutamate levels in the glioma culture media. As the glioma cell lines U87MG and U251MG were cultured in media containing 5% FCS, a high glutamate background was expected as has been previously reported. \[[@R30]\] We determined the background glutamate concentration in culture medium was 34.16 μM ± 12.08 (data not shown). In U87MG cells we observed a significant dose-dependent reduction in extracellular glutamate levels with increasing concentrations of


NT: non-treated, Veh: Vehicle control, Pio: Pioglitazone, GW: GW9662.](oncotarget-06-21301-g007){#F7}

![Extracellular glutamate levels measured with HPLC in U251MG cells incubated with varying concentrations of pioglitazone (a) GW9662 (b) GW9662 + pioglitazone (c & d) for 24, 48 and 72 hours (*n* = 6)\
A significant reduction in glutamate release was elicited at a concentration of ≥ 30 μM of pioglitazone at 72 hours (a). GW9662 at was associated with a significant reduction of glutamate at 48 and 72 hours using 50 μM (b). There was no significant difference in glutamate release with co-administration of pioglitazone and GW9662 (c & d). Bars show mean with SEM and asterisks indicate statistical significance where \**p* = 0.01 to 0.05, \*\**p* = 0.001 to 0.01, \*\*\**p* \< 0.001, and \*\*\*\**p* \< 0.0001. ANOVA with Bonferroniproviding a surrogate for EAAT2 function. Whether pioglitazone also affects glutamate release, glutamate uptake or both requires further investigation.

De Groot and colleagues previously demonstrated that overexpression of EAAT2 in glioma cell lines, including U87MG and U251MG glioma cells, resulted in a reduced ability to form tumours and also caused *in vivo* and *in vitro* apoptosis. \[[@R29]\] Pioglitazone induced EAAT2 upregulation may play a role in reducing glioma cell viability via multiple mechanisms, particularly through the activation of caspase-3, which has been shown in both overexpression studies and cellular apoptosis assays. \[[@R29], [@R33]\]

Deactivation of oncogenic mediators such as Akt and β-catenin has been implicated as possible PPARγ independent mechanisms for PPARγ agonists. \[[@R18], [@R19]\] We observed a reduction in total Akt protein expression levels in U251MG glioma cells following


A. (2005). The influence of depressive symptoms on experimental smoking and intention to smoke in a diverse youth sample. Nicotine & Tobacco Research, 7(2), 243-248.
Ritt-Olson, A., Unger, J. B., Valente, T., Nezami, E., Chou, C.-P., Trinidad, D. R., Milam, J., Tan, S., & Johnson, C. A. (2005). Exploring peers as a mediator of the association between depression and smoking in young adolescents. Substance Use & Misuse, 40(1), 77-98.
Shakib, S., Zheng, H., Johnson, C. A., Chen, X., Sun, P., Palmer, P. H., Yan, L., Jie, G., & Unger, J. B. (2005). Family characteristics and smoking among urban and rural adolescents living in China. Preventive Medicine, 40(1), 83-91.
Unger, J. B., Chou, C.-P., Palmer, P. H., Ritt-Olson, A., Gallaher, P., Cen, S., Lichtman, K., Azen, S., & Johnson, C. A. (2004).expanding the highchair, the actuator 30 is pressed upward once again to permit pivoting of the inner cap 20 in the opposite direction for expanding.
Since positioning in the folding device is achieved through the first and second protrusions 21, 22 of the inner cap 20 and the first and second engaging notched portions 31, 32 of the actuator 30, it is required to operate the actuator 30 when expanding or folding the highchair.


Community hospital level II trauma center outcome.
Currently, level II trauma center standards allow trauma surgeons to take call out-of-hospital. To address the concern that this practice may adversely influence outcome, we tested the hypothesis that the survival of injury victims treated at a level II trauma center is significantly different from that predicted by the Major Trauma Outcome Study (MTOS). In addition, we examined the impact of trauma surgeons taking call out-of-hospital on the survival of patients with severe thoracoabdominal injury. Over a 26-month period, a total of 3,689 consecutive injured patients who were treated at a community hospital level II trauma center were entered into this study. There was no significant difference between the MTOS survival and the actual survival in the overall population (96% vs. 97%,Venomous Animals

CJD

:   Creutzfeldt-Jakob disease ()

CRP

:   C-reactive protein

FDA

:   U.S. Food and Drug Administration

FFP

:   Frozen fresh plasma

GMP

:   Good manufacturing practices

HFS

:   Heterologous fibrin sealant

IL-1

:   Interleukin 1

IL-6

:   Interleukin 6

MCD

:   Minimum coagulant dose

TNF

:   Tumor necrosis factor

TSEs

:   Transmission of spongiform encephalopathies

The authors would like to thank Guilherme Shin Iwamoto Haga, Aristides Pavan, Carlos Antonio Caramori, Márcia Tonin Rigotto Carneiro and Natália Bronzato Medolago for their assistance in the present study. Thanks are also due to the Center for the Study of Venoms and Venomous Animals (CEVAP) of UNESP for enabling the publication of this paper (Edital Toxinologia CAPES no. 063/2010, process no. 230.38.006285/2011-21, AUXPE Toxinologia 1219/2011).

Funding {#FPar1}
=======

This study was supported by the São


Research (CONEP) and received the Certificate of Presentation for Ethical Appreciation (CAAE) -- 19006813.4.1001.5411.

Publisher's Note {#FPar6}
================

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
383 S.W.2d 307; Terminal Warehouses of St. Joseph, Inc. v. Reiners, Mo., 371 S.W.2d 311; Sperry v. Tracy, Dodge-Plymouth Co., Mo., 344 S.W.2d 108. Plaintiff sought recovery under the rear end collision doctrine requiring the jury to find in her Instruction No. 1 "that said defendant (Strebler) then and there negligently and carelessly allowed the front end of his automobile to overtake, run into and collide with the rear end of Mrs. Hays' automobile, * * * and that as a direct result of such negligence, * * * the plaintiff, * * * was injured * * *."
Plaintiff was employed by Lammert's Furniture Company in Clayton, Missouri, as an interior decorator and saleswoman and had been so employed for 18 years. On the morning of May 6,


rear of the one ahead, the proof of a collision under such circumstances makes out a prima facie case of specific negligence against such other person in charge of the overtaking vehicle.'" The above quotation was taken from our case of Hughes v. St. Louis Public Service Co., Mo.App., 251 S.W.2d 360, l.c. 362. The evidence clearly demonstrates that plaintiff was in a portion of the highway where she was entitled to be and that defendant Strebler was traveling behind her in the same direction and in the same lane of traffic and overtook her and permitted his vehicle to run into the rear of plaintiff's automobile ahead of him. As the cases hold, under such circumstances a prima facie case of specific negligence has been made againstdefendant Strebler, the person in charge of the overtaking vehicle. Plaintiff's testimony shows that she was stopped in a lane where she was entitled to be stopped and that she saw defendant Strebler's car behind her and approaching her and traveling in the same direction as she was and that said defendant's car ran into and collided with the rear end of her car. In some respect the testimony of Hodgson confirms the fact that a collision took place between plaintiff's car and the car of defendant Strebler when Hodgson testified that he heard a collision a split second before he came into contact with Strebler's car. This first contention asserted by defendant must be denied.
During the voir dire examination of the jurors plaintiff's attorney informed the court,


attorney.
Hodgson, as heretofore pointed out, was a defendant in the trial below. In the course of the trial below the court admitted into evidence Hodgson's Exhibits A, B, C and D, and permitted testimony concerning these exhibits. Defendant Strebler contends that the trial court erred in such admission and in permitting such testimony. In the cross-examination of defendant Strebler by the attorney for Hodgson, it was disclosed that the Buick automobile driven by Strebler was owned by Leroy Winkler. At Strebler's direction, the Buick automoblie owned by Winkler and driven by Strebler at the time of the accident, was towed to the "Bob Auffenberg Buick, Inc." to be repaired. In the course of Strebler's cross-examination by the attorney for Hodgson, his attention *762 was called to copies ofwere justified and compatible with the type of injury she sustained and that she will continue to have these complaints and difficulties of which she complains for an indefinite period. Plaintiff testified that she had no headaches other than the normal headaches prior to the accident and following the accident she suffered terrific headaches. She testified that following the accident the pain in her upper back and neck was quite severe and as her neck and upper back injury subsided and tended to cause less pain, the lower part of her back continued to bother and to pain her. At the time of her testimony she said that the neck and upper back had not cleared up completely but was more comfortable than shortly after the accident but


rainbow economic financial dominance, get yourself into jail. Roll too many doubles, land on the policeman, do whatever you have to do to get behind bars. Hell, maybe if you’re enough of a dick to your fellow players they will unanimously vote you to be incarcerated, let them. They can’t take your assets once you’re locked up, in this fanciful capitalist wet dream, being detained has no financial detriment except a $50 fine after your third escape attempt.

Purely hypothetically, let’s say you follow these revolutionary tips and tricks and somehow end up on the losing end of the scoreboard. It’s time for some drastic measures because some whack-ass business is going down. Fake a seizure and take out the game board, sympathy and concern are your last ditchfor water collection. The original file only listed the possible CTDs for each experiment. BODC therefore matched as best as possible to the correct CTD and niskin number by using depth as a reference. Where duplicate depths were targeted, the bottle that fired first has been chosen.

For CTD cast 014, there was a large depth discrepancy. The Originator supplied a depth of 110 m and this has been linked to a firing depth of 93 m which was the closest firing depth.

No other discrepancies were found between the Originator's metadata and the metadata held centrally in the database.

Content of data series

The Originator's variables were mapped to appropriate BODC parameter codes as follows:

Originator's Parameter

Unit

Description

BODC Parameter code

BODC Unit

Comments

Nitrate + Nitrite

Micromoles per litre

Concentration of nitrate+nitrite {NO3+NO2} per unit volume of the


have contractile vacuoles, which can pump water out of the cell if there is too much water. The vacuoles of plant cells and fungal cells are usually larger than those of animal cells.

Eukaryotic and prokaryotic

Ribosomes: The ribosome is a large complex of RNA and protein molecules. They each consist of two subunits, and act as an assembly line where RNA from the nucleus is used to synthesise proteins from amino acids. Ribosomes can be found either floating freely or bound to a membrane (the rough endoplasmatic reticulum in eukaryotes, or the cell membrane in prokaryotes).[17]

Many cells also have structures which exist wholly or partially outside the cell membrane. These structures are notable because they are not protected from the external environment by the semipermeable cell membrane. In orderother biological functions. Complex sugars consumed by the organism can be broken down into simpler sugar molecules called monosaccharides such as glucose. Once inside the cell, glucose is broken down to make adenosine triphosphate (ATP), a molecule that possesses readily available energy, through two different pathways.

DNA replication, or the process of duplicating a cell's genome, always happens when a cell divides through mitosis or binary fission. This occurs during the S phase of the cell cycle.

In meiosis, the DNA is replicated only once, while the cell divides twice. DNA replication only occurs before meiosis I. DNA replication does not occur when the cells divide the second time, in meiosis II.[19] Replication, like all cellular activities, requires specialized proteins for carrying out the job.

Protein synthesis

An overview of protein synthesis.
Within


Q:

Exponential backoff for business exceptions when using reactive spring-amqp?

I'm using Spring AMQP 2.1.6 and Spring Boot 2.1.5 and I'm looking for the recommended way to configure spring-amqp to retry business exceptions for reactive components (Mono) with exponential backoff. For example:
@RabbitListener
public Mono<Void> myListener(MyMessage myMessage) {
    Mono<Void> mono = myService.doSomething(myMessage);
    return mono;
}

I'd like spring-amqp to retry automatically if doSomething returns an error. Usually one can configure this for blocking RabbitListener's when setting up the container factory:
SimpleRabbitListenerContainerFactory factory = new SimpleRabbitListenerContainerFactory();
...
factory.setAdviceChain(retryInterceptor(..));

Where retryInterceptor might be defined like this:
private static RetryOperationsInterceptor retryInterceptor(long backoffInitialInterval, double backoffMultiplier, long backoffMaxInterval, int maxAttempts) {
    ExponentialBackOffPolicy backOffPolicy = new ExponentialBackOffPolicy();
    backOffPolicy.setInitialInterval(backoffInitialInterval);
    backOffPolicy.setMultiplier(backoffMultiplier);
    backOffPolicy.setMaxInterval(backoffMaxInterval);

    RetryTemplate retryTemplate = newor type of area (residential, business, etc.).

A second category of works uses *k*-means as the core of their clustering algorithm \[[@B17-sensors-20-03550]\]. In this case, a third factor is considered: similarity between origin--destination transitions among groups. The proposed model was applied to real-world datasets from New York and Washington D.C. This approach may fail in situations where clusters are non-convex and there are physical barriers such as rivers. For this reason, the authors in \[[@B21-sensors-20-03550]\] processed data collected from the New York City Bike System and proposed a spectral clustering algorithm that operates in conjunction with a label propagation algorithm, which controls the geographical extension of the obtained clusters. According to the obtained results, it seems that imposing geographical proximity as a requirement for clustering somehow fades the information


(docking stations) in the set $\mathcal{S}$, we then link different groups of docking stations imposing certain linkage criterion. To this purpose, we define the distance between clusters *X* and *Y* as:$$D\left( {X,Y} \right) = \min\limits_{i \in X,\, j \in Y}d\left( i,j \right).$$

The overall process that HAC-ULECA implements is next described. We start by calculating the value of $d\left( i,j \right)$ for every pair of docking stations within the BSS taken just once, given that $d\left( i,j \right)$ satisfies the symmetry axiom; this results in $S\left( S - 1 \right)/2$ values.

Next we sort the docking stations given these values. In order to do this, we first assign the two stations with the lowest $d\left( i,j \right)$ to the first two positions in the list. Then we take the nextbicycle, updated every minute (this information was not always available).

Among the features these data carried, the time stamp was specially relevant in the calculation of the similarity index $s\left( i,j \right)$ defined in Equation ([2](#FD2-sensors-20-03550){ref-type="disp-formula"}). From a sensitivity analysis point of view, the similarity index was affected by the time interval $\Delta t$. Very low values of $\Delta t$ may have induced low similarity indexes for a given pair of docking stations, which did not reflect their actual comparative behaviour. On the contrary, large values of $\Delta t$ may have shown just an average similarity, hiding the specific features of the behaviour of docking stations, which may have been required to classify them correctly. In our case, BiciMAD recorded data in 1-hour intervals, which was a sensible value


the BSS. Let us start from the simplest one in order to first highlight some features in the performance of the methodology and then extract meaningful information about the behaviour of BiciMAD.

Taking the first 2 levels of the hierarchy results in clusters *A* with 88 and *B* with 81 docking stations. Cluster *A* was formed by the union of first level clusters g\#1 to g\#6 in [Figure 1](#sensors-20-03550-f001){ref-type="fig"}. Accordingly, cluster *B* was formed by the union of first level clusters g\#7 to g\#11.

[Figure 2](#sensors-20-03550-f002){ref-type="fig"} shows the arrival profiles shown at both clusters, separated by day of week. We can clearly observe that, in working days, cluster *A* was characterized by a peak in the morning, whilst cluster *B* shows it in the afternoon. Analysed as whole, these twoChange of Registrant will NOT affect the expiry date of the domain.

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sense, after all, we wanted to spend as much time together on our wedding day as possible! And I was able to smile all the way down the aisle! Not to mention that it allowed us to get pictures (together and with the bridal party) before the ceremony at a relaxed pace. It was perfect.

That being said, the decision to see each other before the ceremony should be yours and yours alone. Not your photographers or your event managers. Not your wedding coordinators or your Mom's. If it's important to you to have that moment when you are walking down the aisle to be your first look, then let that moment be your first glimpse of each other. You won't regret it. But, I have to say, whena reasonable price that will make you as happy with your hair and make-up on your wedding day as I was:

Sunday, November 23, 2008

I wanted to post my series "tying the knot" without disruption, so that the pretty pictures would have time to shine. So, before my next series begins, there are a couple of things that I wanted to share with all of you.

Take a moment to sneak a peek at my new blog header. It was time for a change, friends. Here's the kicker. Once you start, you just can't stop. I have 3 options to choose from! Check them out below and either leave a comment or vote (on the right) for your favorite. I really appreciate it!

Option 1: new current header...

Option 2: add in


things to one another – acquaintance, friend, companion, and even teacher. Now you shall say a few words that take you across a threshold of life, and things will never quite be the same between you. For after these vows, you shall say to the world, this is my husband, this is my wife."previously in the series "tying the knot": we did it, a preview, our honeymoon, our candy bar, lifesaver, getting ready, our first look, the bride and groom, bouquets and boutonnieres, the shoes, the bridesmaids, the groomsmen, the bridal party, the sock shotall pictures by: nicole green. please link back to tying the knot when posting any of these pictures.Introduction {#mmi13880-sec-0001}
============

Peptidoglycan structure and function {#mmi13880-sec-0002}
------------------------------------

Peptidoglycan (also called murein) is one of the largest macromolecules in a bacterial cell, typically forming a mesh‐like structure called the peptidoglycan sacculus that encases the cytoplasmic membrane (Vollmer *et al*., [2008a](#mmi13880-bib-0118){ref-type="ref"}; Weidel and Pelzer, [1964](#mmi13880-bib-0125){ref-type="ref"}). In Gram‐negative (or, more precisely, diderm) bacteria, this peptidoglycan sacculus resides in the periplasm between the cytoplasmic and outer membrane, whilst in Gram‐positive (monoderm) species the peptidoglycan layer is thicker and connected with other major cell wall polymers such as wall teichoic acid, capsular polysaccharide and the S‐layer (Weidenmaier and Peschel, [2008](#mmi13880-bib-0126){ref-type="ref"}; Silhavy *et al*., [2010](#mmi13880-bib-0103){ref-type="ref"}). Peptidoglycan is structurally distinct from cell wall components in archaea and single celled eukaryotes (with the exception of certain plant and algae chloroplasts), and has no homolog in multicellular eukaryotic organisms.


[2013](#mmi13880-bib-0105){ref-type="ref"}).

Peptidoglycan is composed of polysaccharide chains made up of alternating ß‐1,4‐linked N‐acetylglucosamine (Glc*N*Ac) and N‐acetylmuramic acid (Mur*N*Ac) residues which are connected via short peptides (Fig. [1](#mmi13880-fig-0001){ref-type="fig"}) (Weidel and Pelzer, [1964](#mmi13880-bib-0125){ref-type="ref"}; Vollmer *et al*., [2008a](#mmi13880-bib-0118){ref-type="ref"}). These peptides contain D‐amino acids such as D‐alanine or D‐glutamate, as well as unusual non‐proteinogenic amino acids, such as *meso‐*diaminopimelic acid (*meso*‐DAP). The length of individual glycan chains, the amino acid sequence of the peptides and the structure of cross‐links are variable between species and may differ at distinct stages of growth in one species (Vollmer and Höltje, [2004](#mmi13880-bib-0119){ref-type="ref"}; Vollmer, [2008](#mmi13880-bib-0117){ref-type="ref"}; Vollmer and Seligman, [2010](#mmi13880-bib-0121){ref-type="ref"}). Chemical modifications are found in the glycan backbone or peptides, and these may have emerged in response to selective pressure on peptidoglycan from peptidoglycan‐targeting enzymes or antibiotics (Vollmer andinvading bacteria. This is achieved through recognition of characteristic non‐self structures, called pathogen associated molecular patterns (PAMPs). Peptidoglycan is an important PAMP, due to its presence in virtually all bacteria and its almost complete absence in higher eukaryotes. Specific fragments released from peptidoglycan are recognised by various peptidoglycan recognition proteins (Fig. [1](#mmi13880-fig-0001){ref-type="fig"} and Table [1](#mmi13880-tbl-0001){ref-type="table-wrap"}) (Sukhithasri *et al*., [2013](#mmi13880-bib-0108){ref-type="ref"}; Neyen and Lemaitre, [2016](#mmi13880-bib-0081){ref-type="ref"}). The sacculus is hidden from the innate immune system by the presence of an outer membrane in intact diderm bacteria, but soluble peptidoglycan turnover products can be released from intact cells either directly into the surrounding milieu or within outer membrane vesicles. Furthermore, bacterial cells undergoing lysis release peptidoglycan fragments into the extracellular environment. (Goodell and Schwarz, [1985](#mmi13880-bib-0041){ref-type="ref"}; Uehara and Park, [2008](#mmi13880-bib-0113){ref-type="ref"}; Schwechheimer *et al*.,


                                          Cell surface and soluble

Obligate intracellular bacteria {#mmi13880-sec-0004}
-------------------------------

Bacterial species have evolved to exploit an enormous diversity of environmental niches for their growth and replication. One of the most specialised replicative niches is the interior of a living eukaryotic cell. Some bacterial pathogens adopt this niche at some point during their lifecycle (facultative intracellular bacteria) whilst others have become so adapted to this environment that they have lost the ability to replicate in the absence of their cellular host (obligate intracellular bacteria). These intracellular bacteria typically replicate eitheror cholesterol into their membranes, conferring some degree of structural rigidity in the absence of peptidoglycan (Lin and Rikihisa, [2003](#mmi13880-bib-0067){ref-type="ref"}).

Coxiella burnettii {#mmi13880-sec-0008}
------------------

*C. burnettii* is an intracellular γ‐proteobacterium and the causative agent of the human disease Q fever (van Schaik *et al*., [2013](#mmi13880-bib-0114){ref-type="ref"}). It is generally described as an obligate intracellular bacterium, but specific growth media has recently been developed that supports growth in the absence of living host cells (Omsland *et al*., [2009](#mmi13880-bib-0082){ref-type="ref"}). Similar to the Anaplasmataceae and *Chlamydiales, Coxiella* occupies a replicative niche within a membrane‐enclosed vacuole of an infected cell (Kohler and Roy, [2015](#mmi13880-bib-0058){ref-type="ref"}). The *Coxiella‐*containing vacuole, however, is acidified, and this organism has developed mechanisms to survive and proliferate under these conditions (van Schaik *et al*., [2013](#mmi13880-bib-0114){ref-type="ref"}).

*Coxiella* differentiates between the replicative large cell variant (LCV)


species. This includes *C. crescentus* for the alpha‐proteobacteria (Rickettsiales); *E. coli* for the gamma‐proteobacteria (*Coxiella* and *Buchnera*); *B. subtilis* and *M. smegmatis* for the terrabacteria (*Mycobacterium leprae*) and *Akkermansia muciniphila* and *Planctomyces limnophilus* as planctomycetes and verrucomicrobia members of the PVC group respectively (Chlamydiae). These species were selected based on the availability of complete and annotated genomes and experimental evidence on the presence or absence of peptidoglycan (where available). We used a combination of KEGG database analysis and protein homology blast searches to identify proteins involved in different stages of peptidoglycan biosynthesis, and these are shown in Figs 4--7. Organisms are coloured according to their peptidoglycan status, with black indicating the complete absence of any peptidoglycan biosynthetic capacity (*Mycoplasma pneumoniae, Anaplasma phagocytophilum, Ehrlichia ruminatum*), red indicating a demonstratedall proteins considered in this study (full list shown in Supporting Information Table S1) and the proteins are grouped according to their similarities across all organisms considered in this work. The presence of multiple orthologs is indicated by colouring according to the key. \*Class A PBPs contain merged profiles of MrcA (Kegg Accession Number KO5366, see also Supporting Information Table S1), MrcA2/PbpC (KO5367) and MrcB (KO5365). \*\*PBP2 contains merged profiles of MrdA (KO5515) and PBPA (K05364). § Proteins annotated as RodA‐like are present (YP_884452 and NP_301145). \# Protein NP_220201 is not present in Kegg as belonging to the PBP2 family, but it has been identified as such in Ouellette *et al*. ([2012](#mmi13880-bib-0083){ref-type="ref"}). The most similar sequence in *Protochlamydia amoebophila* is WP_011174685.1 (36% identical). \$MSMEG_0031 and MLBr00018 are annotated


genes for a classical peptidoglycan sacculus, the sister genus *Orientia* lacks class A PBPs and was classified as peptidoglycan‐intermediate. The pressure for a reduced peptidoglycan structure in *Orientia* is unlikely to result solely from vector difference (many *Rickettsia* are tick‐borne whilst *Orientia* is mite‐borne) because *Rickettsia akari* is also mite‐borne and possesses complete peptidoglycan genes in common with other *Rickettsia. Orientia* is associated with dendritic cells and monocytes/macrophages in addition to endothelial cells in human patient eschar tissue samples, in contrast to most *Rickettsia*, which are predominantly endothelial‐cell localised. It is possible that this has led to a specific selective pressure on *Orientia* to reduce peptidoglycan, although it is worth noting that *Rickettsia akari* also localises in monocyte/macrophage cells. In common with this line of reasoning, it isU.S. President Barack Obama speaks onstage at 50th Anniversary Of Selma March For African American Voting Rights on March 7, 2015 in Selma, Alabama. Photo: Nicole Craine/WireImage

President Obama’s speech to commemorate the 50th anniversary of the March on Selma provided a stunning visual tableau that communicated a powerful idea — the unimaginable contrast in status between the denial of basic rights of citizenship five decades ago and the existence of a black president today — that could be transmitted through a photograph alone. But Obama’s speech itself did not play a merely ceremonial role, nor was its purpose confined to commemoration and uplift. The president was deeply engaged in an intellectual debate about identity and patriotism.

The unspoken but clear subject of the address was the suggestion raised recently


abolitionists, and civil-rights demonstrators. American history, in Obama’s telling, is the ongoing and inevitably successful struggle to close the gap between its founding ideals and its realities. Obama extended this to such disparate things as the struggle for equality for women and gays, and the striving of immigrants, which have inspired democrats across the globe. Black America’s struggle for freedom represents, in Obama’s telling, the apotheosis of Americanism.

By embedding blackness within American patriotism, Obama also argued against an important tradition on the left. Ta-Nehisi Coates, an important intellectual whose work Obama (to his credit) takes very seriously, has presented racism as the essence of the American story. “White supremacy does not contradict American democracy — it birthed it, nurtured it, and financed it,” he has written. White supremacyto surpass myself to a new way to astonish the viewer with composition that is embedded and communicates freedom”.
His works are pure and his creations are not restricted by any conventions whatsoever. The artist describes his works as self-portraits in the sense that the artwork reveals a mirror image of the soul, energy and emotion of the artist at the moment of creation.

None of the artist's works have a title. Van Gestel states that a title for his works, that portray emotion through pureness of soul, does not add anything to the artwork and so only takes away all essential emotional value from the imagination of the spectator.

Shows
In 1981 Harry van Gestel started working on international shows. Throughout the following years, his works were shown in the Netherlands,


of mechanical loosening or periprosthetic fracture \[[@CR7]\].

The hypothesis tested in this study was that proximal femur bone defect morphology would greatly influence initial stem stability and load transmission to the proximal femur. The purpose of this study was to evaluate the effects of a variety of segmental defects on load transmission to the proximal femur, under both axial and rotational loads, in order to analyze initial polished tapered stem stability.

Methods {#Sec2}
=======

Specimen preparations {#Sec3}
---------------------

Initial stability of the Exeter stem (Exeter V40, 150 mm length, 44 mm offset, size no. 1, Stryker Orthopaedics, Mahwah, NJ) was investigated. A total of 25 composite Sawbones (medium left femur model 3403; Pacific Research Laboratories, Vashon, WA) were prepared. A standard femoral neck cut was made 1 cm proximal to the lesser trochanter. The bones were thenabsolute value of the minimum principal strain in the Square with mesh group (− 32.8 ± 190.3 \[95% CI, − 269.0 to 203.4\]) was significantly smaller than in the Long group (− 423.0 ± 192.0 \[95% CI, − 661.3 to − 184.6\], *p* = 0.013), Short group (− 406.9 ± 158.1 \[95% CI, − 603.2 to − 210.6\], *p* = 0.018), and Square group (− 374.6 ± 165.5 \[95% CI, − 580.0 to − 169.1\], *p* = 0.035). However, there were no significant differences among the Control (− 328.3 ± 140.9 \[95% CI, − 503.2 to − 153.4\]), Long, Short, and Square groups (Fig. [6](#Fig6){ref-type="fig"}).Fig. 5Magnitude of maximum principal strain at 70 Nm of torque with 3 kN of compressive load. a: *p* \< 0.001, b: *p* \< 0.01, c: *p* \< 0.05Fig. 6Magnitude of minimum principal strain at 70 Nm of torque with 3 kN of compressive load. a: *p* \< 0.001, b: p \< 0.01, c: p \< 0.05

In the medio-cranial region, the magnitude of the maximum principal strain in the


bone and bone cement. The arrowheads denote cracks in the cement mantle that were different from the composite bone fracture lines. The arrows denote the cement fracture lines, which are continuous with fracture lines in the composite bone

Discussion {#Sec11}
==========

The purpose of this study was to evaluate the effects of a variety of segmental defects on load transmission to the proximal femur, in order to analyze initial polished tapered stem stability. Bolder et al. reported that the presence of a large medial segmental defect in the femur specifically reduces prosthetic stability, and that metal mesh was effective in creating a stable stem construction in a goat femur model \[[@CR3]\]. However, the specific extent of a bone defect that can cause severe reduction of initial stem stability remains unclear. Therefore,in an in vitro polished tapered stem model \[[@CR11], [@CR12]\]. The present study suggests that, if revision THR is performed without reinforcement despite a morphologically wide bone defect, the mechanical stress is concentrated excessively in the bone cement, and this excessive mechanical stress may cause early periprosthetic fracturing, cement cracking, and/or lead to early mechanical loosening. These results suggest that, even if a bone defect fits Paprosky classification type 2A \[[@CR13], [@CR14]\], when wide medial segmental defects more than 3 cm in width are present, reinforcement is necessary to prevent periprosthetic fracture or early mechanical loosening.

Although the areas of the defects of the Long group and the Square group were nearly equal, neither complex failure nor cement cracking was observed in the Long group. The present study showed that


distally extended bone defects categorized as Paprosky classification type 2C, such as the Long group defect, affect initial stem stability less than wider defects, such as the Square group defect.

In the medio-cranial region, the magnitude of the maximum principal strain in the Long group was significantly larger than in the Control group, the Short group, and the Square with mesh group. In the same region, the absolute value of the minimum principal strain in the Long group was also significantly larger than in the Control group, and the Square with mesh group. Meanwhile, in the antero-cranial region, the magnitude of the maximum principal strain in the Long group was significantly the smallest among the five groups, although the absolute value of the minimum principal strain showed no differenceOrder 1997 (S.I. 1997/266)
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a phone, would he?" "Look, why would he?" "He had a warrant, didn't he?" "Then if he didn't, who did?" "Boss, what's going on?" "Nothing, Benny, nothing." "I'll let you crack on." "(ENGINE REVS)" "(TRAIN RUMBLES BY OUTSIDE)" "(MURMUR OF DIFFERENT TV CHANNELS)" "(FOOTSTEPS)" "(RECORD CRACKLES)" "(KNOCK)" "Julian Lewis!" "Police!" "Open up!" " Armed police!" "Armed police!" " Search!" " Searching!" " Bathroom clear!" " Clear!" "Medic says he ate the tongue." "Boss, what do we do with something like this?" "We keep going." "Trace it back to a point of origin." "First cause." "And there we will find our man." "Belongs to a Bruno Dresller." "How are you?" "Well, to be honest, boss, I don't know how I am." " She was..." " Yeah, she was." "Anyteenagers." " I'm on my way." " Roger." "We've got a body in the bath." "Dissolved in lye, apparently." "Very old school." "Could be Dresller." "Hard to tell." "The head and hands are missing." "Ok." "With you in five." "(PHONE VIBRATES)" " Yeah?" " John, Theo." "Can you talk?" "Sorry to impose." "I need a disinterested ear." "Yeah." "Course." "Go on." "You ever had your nose pressed up too close to something?" "Er, yeah, once too often." "I can't see it, John." "Or I can't see past it, or something." "I'm, er, like one of those drawings... you're looking at a profile of an old hag." "You know there's a portrait of a young girl in there somewhere." "You just have to refocus somehow." "Ok." "What are we


want to say..." "..whatever it takes... ..you know?" "I'm in." "Anything?" "Anything." "(HE SIGHS)" "You've got a family?" "Yeah." "Your girlfriend's expecting a baby?" "Six weeks." "You love her?" "More than anything." "That's good." "There are some things that you might have heard about me that quite possibly could be true." "I know what you're going through right now." "I sincerely do." "But there's something I need you to hear from me." "Never cut corners." "Never." "Not even if you know no-one else will know, no-one else will find out that it is exactly the right thing to do... because it never, ever is." "Ever." "You do this the right way." "All right, straight down the line." "You do it that way or I get you kicked offwas last year, so we thought, yeah, I know, we thought you could all come to ours this year..." "I know, why not, right?" " Hello?" " Hello?" "Is this Alastair's mum?" "Who is this?" "I was with him..." "When he died." " Who are you?" " He was asking for you at the end." "When he couldn't fight any more." "(CRYING DOWN THE PHONE)" ""Mum." "Mum."" "He was so scared of dying." "Why would you do this?" "!" "(HE GROANS)" "What you got?" "Well, you were right." "We found spyware deep in Dresller's laptop." "How closely was he being watched?" "Close enough to know everything there is to know." "It's not just passwords and bank account log-ins." "Whoever's been watching him knows every sentence he's composed, every


ULTA HAUL! Lorac, IT Cosmetics, Stila, Benefit

Last week I shared my Ulta haul on youtube, and wanted to make sure it got posted here too! I originally went in for one thing, and, in Ulta fashion, left with quite a few things :) I made sure to pick up some palettes I’ve heard lots about, and am working on getting reviews up for you all! Hope you enjoy, and let me know what the last things you hauled were :)

I know everything I wrote up above about style points and that scaring me off wide lines, but this is stunning. The Demon Deacons have not givenSexual assault survivor Brenda Tracy says that photos of Baylor fans buying t-shirts in support of former head football coach Art Briles wasbrain activation should be pivotal in the representation of emotion regulation, which was confirmed by substantial studies (Thiruchselvam *et al*., [@ref110]; Paul *et al*., [@ref87]; Pavlov *et al*., [@ref88]; Koval *et al*., [@ref57]). Since the mid-1990s, the dynamics of the brain at rest has been attracting a growing body of research in neuroscience. Neuroimaging studies have revealed distinct functional networks that slowly activate and deactivate, pointing to the existence of an underlying network dynamics emerging spontaneously during rest (Fox *et al*., [@ref32]; Deco *et al*., [@ref21]; Ciuciu *et al*., [@ref18]). Several studies have already shown that DMN dynamics is disrupted in depression (Hamilton *et al.*, [@ref42]; Wei *et al*., [@ref118]; Kaiser *et al.*, [@ref55]), and abnormal dynamic RSFC in MDD was associated with medial prefrontal and temporal regions


only to the index of H of DMN. Therefore, future studies should apply multiple approaches to delineate brain network dynamics like sliding window methods (Kaiser *et al.*, [@ref55]), co-activation pattern analysis (Chen *et al*., [@ref16]) and multi-layered dynamic analysis (Raz *et al.*, [@ref94]) to further confirm the observed associations in follow-up studies. Third, only healthy young participants were studied, and it is therefore unknown whether our results are generalizable to all age groups. Because age differences are often observed in studies of emotion regulation (Martins *et al*., [@ref73]; Scheibe *et al*., [@ref100]), it is important to examine whether there is an association between emotion regulation tendencies and age differences. Fourth, MDD patients are not involved in the current study. Thus, individual differences in temporal dynamics of DMN inMDD patients and its association with emotion regulation tendencies should be examined in future studies. Finally, recent study has found that the mutual information function of neurophysiological data behaves differently from fGn, and the H phenomenon is a sufficient condition to prove long-range memory only in the stationary fGn process (Von *et al*., [@ref116]). Thus, the interpretation that the long-range memory can be predicted by Hurst exponents correctly should be more cautious, and future study should use the time-lagged mutual information function (a novel and effective tool to assess long-range dependence in finite length empirical data) as a complementary method to measure memory effects.

Conclusion {#sec19}
==========

In conclusion, the present study provides first evidence for a negative association between the use of cognitive reappraisal and the temporal dependence of DMN


comparison with the Grand Canyon is often made and, whilst not as extensive, it is nevertheless impressive. The road up to it is long and windy with beautiful views over the inland area and to the coast. I drove to the last viewpoint where I was rewarded with a wonderful outlook of the rocky coastline of the Napali Coast.

Napali coast

Colourful Waimea canyon
There are many hiking trails in the canyon area and I had spent some time studying which one to do. There were dire warnings about those tracks which only experienced hikers should tackle and I played it safe; too safe. I chose the Canyon trail, which seemed to be the most popular, judging by the number of people on it. It didn’t take me as long asthe wharf still stands intact. In the past, there had been many Chinese and Japanese immigrants, who played an important part in the trading history of the area. They also influenced the styles of the buildings, some of which remain today. There is still a strong Japanese influence in local businesses.

Abandoned building in Waimea

Building in Waimea

Japanese style house in Waimea

Sign outside shop in Waimea

Wharf at Waimea

On the way back, an impromptu diversion took me to Salt Pond Park, where many families were enjoying the late afternoon sun. The salt ponds next to the beach are maintained by specific families. The quantity of salt produced depends on the amount of rainfall and the degree to which the water dries out. This year’s harvest could be in jeopardy because of


---
abstract: 'By means of novel volume-diameter aspect ratio diagrams, we ponder on the current conception of crater morphogenesis analyzing crater data from beam explosions, hypervelocity collisions and drop experiments and comparing them with crater data from three moons (the Moon, Callisto, and Ganymede) and from our own experimental results. The distinctive volume-diameter scaling laws we discovered make us to conclude that simple and complex craters in satellites and planets could have been formed by granular-against-granular collisions and that central peaks and domes in complex craters were formed by a dynamic confinement of part of the impacting projectile, rather than by the uplift of the target terrain. A granulometric analysis of asteroids and central peaks and domes inside complex craters, shows boulder size distributions consistent with our hypothesis thatformation of a central peak in some craters.

The opening mechanism of a granular-against-granular collisional crater is depicted in Fig. \[Diff\] and Fig. \[Sequence\], where a sequence of pictures of the crater formation process is presented. Images in Fig. \[Diff\] were subtracted by means of an Image J algorithm in order to stress out material mobilization during ejection or compression processes.

In order to visualize and characterize the opening crater process and its final morphology, we defined four symmetric regions of the crater: distal area; outer crater rim; left and right inner crater rim and crater floor. The thickness of each layer was measured on a frame before the impact and after the formation of the crater process was ended. We measured the full length of each layer with a spatial bin length


(They can also receive matching funds from the state; a range rider might cost up to $20,000 for an entire season.)

“There’s the idea that folks out here (in eastern Washington) hate wolves or love wolves, and you have to be one or the other,” Kehne says. “But a lot of people aren’t that way. They’re in the middle, they’re pragmatic.”

Indeed, the state’s ranching community has proven more amenable than might be expected, and has been cautiously, if at times skeptically, supportive of state efforts to reintegrate wolves as painlessly as possible. “I think the WDFW has great conflict specialists on the ground,” says Jack Field, vice president of the Washington Cattlemen’s Association. “They have shown a significant willingness to put producers’ interests first.”

But the ranchers’ tolerance has itsN'Ko script

N'Ko () is a script devised by Solomana Kante in 1949, as a writing system for the Manding languages of West Africa. The term N'Ko, which means I say in all Manding languages, is also used for the Manding literary standard written in N'Ko script.

The script has a few similarities to the Arabic script, notably its direction (right-to-left) and the letters which are connected at the base. Unlike Arabic, it obligatorily marks both tone and vowels. N'Ko tones are marked as diacritics, in a similar manner to the marking of some vowels in Arabic.

History

Kante created N'Ko in response to what he felt were beliefs that Africans were a culture-less people, because before then, no indigenous African writing system for his language existed. N'Ko was invented in Bingerville,


Côte d'Ivoire and then brought to Kante's natal region of Kankan, Guinea before being disseminated into other Manding-speaking parts of West Africa. N'Ko Alphabet Day is April 14, relating to the date in 1949 when the script is believed to have been finalized.

The introduction of the script led to a movement promoting literacy in the N'Ko script among Manding speakers in both Anglophone and Francophone West Africa. N'Ko literacy was instrumental in shaping the Maninka cultural identity in Guinea, and it has also strengthened the Manding identity in other parts of West Africa.

Current use
As of 2005, it is used mainly in Guinea and the Ivory Coast (respectively by Maninka and Dyula speakers), with an active user community in Mali (by Bambara-speakers). Publications include a translation of the Quran,it on anyone.

FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of political, economic, scientific, and educational issues. We believe this constitutes a 'fair use' of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. For more information go to:


know there will be an enforcement, and they will have to pay in the end."

Bailiffs need more tools

The Bailiffs Chamber of Quebec has also asked the government to give them more tools to help plaintiffs collect.

Chamber President André Bizier said many clients show up after winning a case in small claims court, with no information about the debtor. And because it can take time to collect judgments, the debtor has often moved, leaving no forwarding address.

"We've asked for a secure system where we can get information on the losing defendant," said Bizier. "An address, a place of work, even license plates."

He said bailiffs, too, have gotten nowhere with the government.

The provincial government said some amendments to the Quebec Civil Code in 2016 will reduce costs for citizens whouse small claims court. The amount collected from the sale of seized property will also be increased.

And while it may be hard to collect, the province points out that judgments last for ten years. So if the person doesn't have money now, they might in a few years.

One man's story

Stefan Kambiz Behfar sued a Montreal-based developer earlier this year over the developer's alleged failure to honour a promise to purchase Behfar's land.

A judgment was made in his favour, but the developer, who didn't appear in court, asked a judge to revoke the decision several weeks later.

The judge was comfortable with the reasons the defendant gave for his inability to appear at the first hearing, and a new hearing is set for next year.

Meanwhile, Behfar is out of pocket


or more specifically, receiving a packet in the context of classical TCP. For example, if a packet ${\mathbf p_k}$ is decoded then it is indeed also seen, as $\mathbf{q}=\mathbf{0}$. A node can compute any linear combination whose coefficient vector is in the span of the coefficient vectors of previously received linear combinations. This leads to the following definition.

The *knowledge of a node* is the set of all linear combinations of original packets that it can compute, based on the information it has received so far. The coefficient vectors of these linear combinations form a vector space called the *knowledge space* of the node.

We state a useful proposition without proof (see Corollary 1, [@ARQforNC] for details).

\[witness\] *If a node has seen packet $\mathbf{p_k}$, then it knows exactly one linearappears as though the degree of freedom waits in a fictitious queue until the channel stops erasing packets and allows it through. Thus, there will never be any duplicate ACKs. Every ACK will cause the congestion window to advance. In short, *the lossiness of the link is presented to TCP as an additional queuing delay that leads to a larger effective round-trip time*. The more lossy the link is, the larger will be the RTT that TCP sees. The natural question that arises is – how does this affect congestion control? Since we mask losses from the congestion control algorithm, the TCP-Reno style approach to congestion control using packet loss as a congestion indicator is not well suited to this situation. However, it is useful to note that


the matched transmission is then loaded into the transmit timestamp echo field of the TCP ACK packet and delivered to TCP. Thus, the TCP sender is intentionally mislead into computing the fictitious RTT for the degree of freedom.

The algorithm is specified below using pseudo-code. This specification assumes a one-way TCP with the timestamps option turned on.

### Source side

The source side algorithm has to respond to two types of events – the arrival of a packet from the source TCP, and the arrival of an ACK from the receiver via IP.

1.  Set $TX\_SERIAL\_NUM$ and $NUM$ to 0.

2.  [*Wait state:*]{} If any of the following events occurs, respond as follows; else, wait.

3.  [*Packet arrives from TCP:*]{}

    1.  If the packet is a controlnode is in the ON state ([[*i.e.*]{}]{}, no erasure), the node’s version of the sink’s status is updated to that of the previous node. In practice, the source need not transmit the sink’s status explicitly. The intermediate nodes can infer it from the set of packets that have been involved in the linear combination – if a packet is no longer involved, that means the source must have dropped it, implying that the sink must have ACKed it already. Whenever an intermediate node receives an innovative packet, this causes the node to see a previously unseen packet. The node performs a Gaussian elimination to compute the witness of the newly seen packet, and adds this to the queue. Thus, intermediate nodes store the witnesses of the packets that


leaders not moving to end an egregious injustice - which denies us cash to fund the transformation of our country into a developed nation, and prosperous society, from our own resources?

The question the good people of Ghana ought to ponder is: if those elected leaders who signed those rip-off agrements had a fiduciary duty to ensure that the bulk of those US$160 billions would accrue to the Republic of Ghana and its citizens, but failed to do so - because entering into rip-off- agreements beneficial to foreign oil companies benefited them personally - why are President Mahama and Dr. Bawumia not protesting loudly and demanding that those agreements must be renogotiated: so that proceeds from the sale of Ghanaian oil and gas can be used to modernise and- and that they must be replaced with production sharing agreements in which Ghana gets 70 percent, whiles 30 percent of the proceeds go to the oil companies, whenever oil is lifted.

If that were the case today, and a production sharing agreement was in place, we would not be an over-leveraged nation beholden to tightfisted and canny bankers in China, but would rather have the wherewithal to transform our nation into an African equivalent of the egalitarian societies of Scandinavia - blessed with well-equipped hospitals in every district capital; have free education from kindergarten to tertiary level for the younger generations; have well-designed and well-built housing in well-planned new green cities that millions of ordinary people could afford to purchase houses in.

Were the situation, in which an oil-rich


nation and its citizens face penury, because a few selfish and greedy individuals signed what are inimical agreements with foreign oil companies, to persist, it could lead to the demise of Ghanaian democracy - and the emergence of a Colonel Gaddafi-type leader: who will tear up those inimical agreements. Under King Idris 1, Libya's oil deposits benefited the king personally, and the foreign oil companies: not the Libyan people and their nation.

That is why Gaddafi became a hero to Libyans when he overthrew King Idris in 1969. An African democracy that fails to produce ordinary citizens' share of the democracy dividend, faces a shaky future - as poverty and democracy do not make good bedfellows. Our hard-of-hearing and self-seeking ruling elites, who take a lot for granted, have  <Str Cat="Text">
          <Val><![CDATA[Objects names should not be in camelCase]]></Val>
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            <Val><![CDATA[物件名稱不得使用駝峰式大小寫格式]]></Val>
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brace must not be on its own line and should always be followed by a newline]]></Val>
          <Tgt Cat="Text" Stat="Loc" Orig="New">
            <Val><![CDATA[左大括號不得自成一行，且其後一律須接新行]]></Val>
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     as direct functional targets of miR-30b/c in NSCLC cells and miR-30b/c was down-regulated in NSCLC tissues compared to adjacent non-tumor tissues. Furthermore, ectopic overexpression of miR-30b/c blocked tumor cell proliferation *in vitro*. These data suggested that the reduced expression of miR-30b/c might facilitate the development of NSCLCs.

Methods {#Sec2}
=======

Specimens {#Sec3}
---------

In this study, 5 paired NSCLC and adjacent non-tumor specimens were collected from the Department of Respiratory Medicine, the Second Affiliated Hospital, Second Military Medical University (Shanghai, China). All tissue samples were flash-frozen in liquid nitrogen immediately after collection and stored at -80°C until use. The study protocol was approved by Shanghai Changzheng Hospital Ethical Committee. Informed consent was obtained from all patients. All clinic pathologic and biological data were available for those patients. Both tumor and non-tumor samples were


that Rab18 was one direct functional target of miR-30b/c in NSCLC cells. Transfection of miR-30b/c mimics into NSCLC cells led to a significant Rab18 decrease at protein levels but not mRNA levels and inhibition of cellular proliferation. Furthermore, silencing Rab18 expression by siRNA in NSCLC cells also led to inhibition of cellular proliferation. These findings support the hypothesis that decreased expression of Rab18 by miR-30b/c accounts for the suppression of cellular proliferation in NSCLC. Our results agreed with the previous study in HCC which showed that Rab18 was directly targeted and down-regulated at protein levels by miR-429 in HCC cells, but whether the expression of Rab18 was also regulated at transcriptional levels in NSCLC cells just like that by hepatitis B virus X protein stimulation in HCC cellsTICKET Box office hours will be 1:00PM – 10:00PM on Saturday, 27 July.

WILL YOU BE POSTING SET TIMES IN ADVANCE?

WILL THERE BE A LIVESTREAM? At this stage, we’re not planning to livestream Group Therapy Weekender.

CAN I ENTER, LEAVE AND RE-ENTER GROUP THERAPY WEEKENDER? You can leave and re-enter the venue up until 2pm both days of the festival.

I’M A MEDIA REPRESENTATIVE. WHO DO I ARRANGE A PRESS PASS THROUGH? Email contact@anjunabeats.com with details about your outlet. We’ll read all requests - if we don’t get back to you, unfortunately your request has been denied.

CAN I PASS OUT FLYERS AT THE FESTIVAL? No, please don’t.

WILL THERE BE ATM MACHINES? Yes, magical money machines will be on site. Smart campers will bring cash in advance to avoid queues.

WILL THERE BE


the Standing Committee on the Status of Women.

However, her term as an MP would be short-lived, as she was defeated in the federal election the following year in the redistricted riding of Whitby by Celina Caesar-Chavannes, who she had earlier defeated in the by-election.

Electoral record

Federal

Mayor of Whitby, Ontario

2010

2006

References

External links
 Official website
 Pat Perkins - Parliament of Canada biography
 Pat Perkins - PARLINFO

Category:Conservative Party of Canada MPs
Category:Living people
Category:Mayors of places in Ontario
Category:Members of the House of Commons of Canada from Ontario
Category:People from Whitby, Ontario
Category:Women members of the House of Commons of Canada
Category:Women mayors of places in Ontario
Category:1953 births
Category:21st-century Canadian politicians
Category:21st-century Canadian women politiciansNEVER CHECK THE TURN HERE! He can have Qx, 9x, flush draws, straight draws, there is just so many hands that he will call you with that betting is mandatory in this spot. You want to get as much money into the pot as you can, and I would bet big here because the boars is so drawy.

If you had more hands on your opponent and he was very aggresive I would sometimes check with the intention of raising if he bets to get more money into the pot. But since you have only 8 hands on your opponent I woud bet in this spot allways.

This is for sure. Always bet here if he check or raise if he bet. Board is very drawy so there are many


gone into making this happen over the past few months and we are delighted to get it over the line," Blease said.

"Opportunities to sign players this talented do not come along too often and it speaks volumes that we have beaten off some serious competition for his signature.

"I'd like to thank the player's agent for all his help as well as Marwan Koukash, who has honoured his pledge to support the club with the acquisition of a player.

"It is vital we stay in Super League this year and the signing of Jackson Hastings shows that we are very serious about this aim."

Salford has lost seven of its past eight matches and could be confirmed in the bottom four if results go against the club on Friday night, whenA defensive end who figures to make things miserable for college quarterbacks, and a quarterback who could do the same thing to college defenses, are the headliners on the 31st edition of the Press-Telegram s Best in the West football team.

Everson Griffen, that dominating defender from the Phoenix suburb of Avondale, came very close to getting a perfect point total finishing with 207 out of a possible 210 and was designated the top college prospect in the Western class of high school seniors.

Griffen, in a poll of seven high school recruiting analysts, heads a 20-player BIW first team that includes as many as 11 others who could sign national letters of intent with the Trojans on Feb. 7, the first day of the NCAA s football signing period.

Finishing


to a CIF Southern Section title in December, plans to sign with UCLA.

Two players from the Orange Lutheran team that won the strongest of the CIF Southern Section divisions (Pac-5), Aaron Corp and Michael Reardon.

Corp, a USC-bound quarterback, was ninth in the balloting and was also the Pac-5 Offensive Player of the Year.

Reardon (11th in the voting) is a two-way lineman who is expected to get his first shot at USC on offense.

The best prospect in Northern California, Richmond Salesian running back Jahvid Best, is expected to sign with Cal, where he could play a lot next season with the departure to the NFL of Marshawn Lynch.

The brother of a former BIW selection, Steve Smith of USC, Malcolm Smith, a star linebacker and running back at Woodland Hills

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