use cases
 *
 * {@see DefaultAuthenticationEventPublisher}
 */
public class DefaultAuthenticationEventPublisherBearerTokenTests {

	DefaultAuthenticationEventPublisher publisher;

	@Test
	public void publishAuthenticationFailureWhenInvalidBearerTokenExceptionThenMaps() {
		ApplicationEventPublisher appPublisher = mock(ApplicationEventPublisher.class);
		Authentication authentication = new JwtAuthenticationToken(TestJwts.jwt().build());
		Exception cause = new Exception();
		this.publisher = new DefaultAuthenticationEventPublisher(appPublisher);
		this.publisher.publishAuthenticationFailure(new InvalidBearerTokenException("invalid"), authentication);
		this.publisher.publishAuthenticationFailure(new InvalidBearerTokenException("invalid", cause), authentication);
		verify(appPublisher, times(2)).publishEvent(isA(AuthenticationFailureBadCredentialsEvent.class));
	}

}
quick"

The three-time World Champion did another 10-lap run on the same set of tyres, and set a best time in 49.09 seconds.

“He came back into the pits and said 'Thank you very much, I've learned what I need to know.' He got out of the car and that was that,” Beresford continued.

“Senna did not disappoint me at any level. He was just amazingly quick. Emmo’s best lap was a 49.7 compared to Senna's 49.09.

"At the end of the day, Emerson did a 48.5 in the new Penske, and that was just 0.6s quicker than Senna. That was very good considering Ayrton was driving a year-old car on old tyres.

"To me that indicated just how extraordinarily quickly he was able to adapt himself and approach competitive times."


include genes that are known to play roles in hypoxia and viral pathogenesis; i.e. nuclear enriched abundant transcript 1 (NEAT1) \[[@ppat.1006143.ref043],[@ppat.1006143.ref044]\], integrin alpha 5 (ITGAV) \[[@ppat.1006143.ref045],[@ppat.1006143.ref046]\] and baculoviral IAP repeat-containing 3 (BIRC3) \[[@ppat.1006143.ref047],[@ppat.1006143.ref048]\]. While there was considerable overlap, of the 210 genes that were up-regulated by hypoxia (*P* ≤0.05 and FC≥2), a substantial number (155) remained unchanged with KSHV infection and 6 were down-regulated by KSHV (*P* ≤0.05 and FC ≤-2) (**[Fig 2A](#ppat.1006143.g002){ref-type="fig"}**). To get a better sense of how these hypoxia-responsive genes were affected by KSHV infection, we plotted the KSHV-induced changes in the genes that met our cut-off criteria for up-regulation by hypoxia (*P* ≤0.05 and FC ≥2) (**[Fig 2B](#ppat.1006143.g002){ref-type="fig"}**). As can be seen, while a number of genes were significantly up-regulated under both conditions (49(miR-4671-3p and miR-210) were up-regulated, while the other eight were down-regulated; the most abundant down-regulated miRNAs were miR-548b-3p and miR-1270.

Similarities between KSHV infection and hypoxia in endothelial cells and AIDS-KS {#sec007}
--------------------------------------------------------------------------------

In order to further explore the relationship between the cellular genes affected by KSHV infection and those affected by hypoxia, we analyzed the reported results of two studies of human umbilical vein endothelial cells (HUVECs) \[[@ppat.1006143.ref051],[@ppat.1006143.ref052]\]. KS spindle cells are thought to be derived from endothelial cells, and HUVECs can thus potentially provide more insight into the pathogenesis of KS than SLK cells. One study used microarray to analyze the genes whose expression was modulated by *de novo* KSHV infection of HUVECs (48 hrs post-infection) \[[@ppat.1006143.ref051]\], while the other used RNA sequencing to analyze HUVECs exposed to hypoxia


hypoxia were significantly down-regulated by KSHV infection (**[Fig 2B](#ppat.1006143.g002){ref-type="fig"}**). Also, there was a strong positive correlation between the hypoxia-induced mRNA changes in SLK and SLKK cells (Pearson correlation coefficient of r = 0.72). Among the 51 mRNAs up-regulated in both SLK and SLKK cells, BNIP3, a pro-apoptotic gene known for being one of the most hypoxia-responsive genes \[[@ppat.1006143.ref064],[@ppat.1006143.ref065]\], had its mRNA levels increased 4 fold due to hypoxia in both infected and uninfected cell lines. MIR210HG, the host gene for miR-210, was also one of the responders in common between the two cell lines. There were 14 genes that met our cut-off values for down-regulation in both SLK and SLKK cells (**[Fig 5A](#ppat.1006143.g005){ref-type="fig"}**). VCAM-1 was one of the significantly down-regulated mRNAs in both cell lines, with -1.4 andmediated by the virus and others as part of the host response to infection. Previous studies have shown that hypoxia and HIFs can affect KSHV biology and KSHV-induced tumor formation \[[@ppat.1006143.ref006],[@ppat.1006143.ref007],[@ppat.1006143.ref059]\]. Moreover, KSHV infection and LANA, a KSHV-encoded latent gene, have been shown to induce the up-regulation of HIF \[[@ppat.1006143.ref016]\] and at least one HIF-responsive gene (VEGFR1) in newly infected endothelial cells \[[@ppat.1006143.ref023]\]. Also, several HIF-responsive genes related to angiogenesis or metabolism have been shown to be elevated in immortalized HUVECs chronically infected with KSHV \[[@ppat.1006143.ref070]\]. However, these data do not provide a complete picture of the cellular response to KSHV infection and the role that hypoxia plays. To further investigate these relationships, we used RNA-Seq analysis to assess the changes induced by hypoxia in SLK cells and


3.2 fold) and by KSHV infection (14.9 fold change) (**[S1 Table](#ppat.1006143.s006){ref-type="supplementary-material"}**). Interestingly, KSHV protein K15 also up-regulates BIRC3 \[[@ppat.1006143.ref047]\], which suggest that the up-regulation in KSHV infection can occur through both HIF-dependent and independent mechanisms. By interfering with apoptosis, BIRC3 can inhibit the ability of KSHV-infected cells to destroy themselves (and the infecting virus) \[[@ppat.1006143.ref074]--[@ppat.1006143.ref076]\]. Another gene that is up-regulated by both hypoxia and KSHV infection is NEAT1, a host long non-coding RNA involved in nuclear paraspeckle formation. There is evidence that NEAT1 plays an important role in regulating gene expression \[[@ppat.1006143.ref077],[@ppat.1006143.ref078]\]. NEAT1 has also been found to increase the survival of cancer cells \[[@ppat.1006143.ref043]\], and may thus benefit KSHV infection by preventing the death of KSHV-infected cells.

Up-regulation of genes such as BIRC3 or NEAT1 would presumably beproducts contained in the libraries using a high sensitivity DNA chip and an Agilent 2100 Bioanalyzer (Agilent Technologies). Finally, a total of six miRNA libraries (three SLK and three SLKK samples) were sequenced using the Illumina HiSeq platform.

Preparation of polyadenylated mRNA libraries for deep sequencing {#sec022}
----------------------------------------------------------------

Total RNA of samples used for small RNA-Sequencing was treated with Turbo DNA-free DNase I and Dynabeads (both from Ambion, Life Technology) to deplete samples from the residual DNA and to isolate the polyadenylated mRNA transcriptome, respectively. PolyA+ RNA libraries were then prepared with the ScriptSeq v2 RNA-Seq kit (Epicentre, Madison, WI). The final concentration and size distribution of the RNA libraries were measured by using a Nanodrop-ND-1000 spectrophotometer (Thermo Fisher Scientific), and by running a DNA 100 chip on an Agilent 2100


   void *);
void *_InterlockedCompareExchangePointer_HLERelease(void *volatile *, void *,
                                                    void *);
long _InterlockedExchangeAdd_HLEAcquire(long volatile *, long);
long _InterlockedExchangeAdd_HLERelease(long volatile *, long);
__int64 _InterlockedExchangeAdd64_HLEAcquire(__int64 volatile *, __int64);
__int64 _InterlockedExchangeAdd64_HLERelease(__int64 volatile *, __int64);
void __cdecl _invpcid(unsigned int, void *);
static __inline__ void
__attribute__((__deprecated__("use other intrinsics or C++11 atomics instead")))
_ReadBarrier(void);
static __inline__ void
__attribute__((__deprecated__("use other intrinsics or C++11 atomics instead")))
_ReadWriteBarrier(void);
unsigned int _rorx_u32(unsigned int, const unsigned int);
int _sarx_i32(int, unsigned int);
#if __STDC_HOSTED__
int __cdecl _setjmp(jmp_buf);
#endif
unsigned int _shlx_u32(unsigned int, unsigned int);
unsigned int _shrx_u32(unsigned int, unsigned int);
void _Store_HLERelease(long volatile *, long);
void _Store64_HLERelease(__int64 volatileThe UK marine power sector needs to go further, faster.

Those were the words of Greg Barker, Minister of State for Energy and Climate Change, who spoke at the RenewableUK Wave and Tidal Conference in London last month.

He said that now is the time to make "bold steps" in an effort to move individual projects to wide commercial arrays. And that is exactly what the industry and the government is doing.

"Now is the time to make "bold steps" in an effort to move individual projects to wide commercial arrays."

In just over a week, tidal companies MeyGen and SeaGeneration Wales have been awarded £20m in funding for their projects off the coast of Caithness and Anglesey; the Scottish Government announced it will provide £3m to the European Marine Energy Centre


as well as 2,000 students hoping to become tomorrow's problem solvers in the wave and tidal sector.

"The £19m Marine Building, opened by the Duke of Edinburgh in October 2012, is Europe's largest marine institute."

One of the key features of the Marine Building is the Coastal Ocean and Sediment Transport (COAST) laboratory, which offers equipment designed for device and array testing, environmental modelling and coastal engineering.

The lab includes three tanks and flumes - the Ocean Wave Basin, Coastal Basin and Sediment Wave Flume - which differ in size and depth to produce waves of up to 0.9m in height.

Students, along with researchers and small marine energy businesses, can carry out their experiments here.

The first commercial testing at the lab was carried out by Offshore Wave Energy and IT PowerLOS ANGELES (AP) Although the wordless billboards went up quietly this week on the streets around Los Angeles FC's Banc of California Stadium, their message to the city is loud and clear.

Some of the huge signs show imperious LA Galaxy striker Zlatan Ibrahimovic running into LAFC's Latif Blessing, sending the smaller man flying. In others, Zlatan is making a saucy gesture toward LAFC's Carlos Vela, or perhaps celebrating in his fellow superstar's face.

Each of the photos captured a triumphant moment for Zlatan and the Galaxy during the first four editions of El Trafico, the increasingly outstanding rivalry series between Major League Soccer's two Los Angeles clubs. LAFC's fans have the best team in the league this season, but it has never beaten the Galaxy - and those fans


final saga being the discovery of the Higgs Boson. The stage now lies open for dynamics beyond what we have grown to understand as Standard. Yet, our understanding of a significant part of SM dynamics lacks solid grounding and leads the lack of predictability in many arenas that have been somewhat neglected in the race to discover theoretically established resonances. Charm dynamics is one such important arena which stands on the threshold that can be, at best, called “pseudo-perturbative” dynamics. Not only is it capable of giving us important insights into the workings of the SM in an area which is, and has always been, gray, but also serves as a testing ground for innovations in theoretical technologies beyond what is well established.

Testing for the presence of newrelayed to Chartwells' management and what reasons Chartwells relied on in terminating Bryant. Of primary importance on this issue is the uncontroverted testimony of a disinterested third party, officer Bowden. The record indicates that he informed Chartwells management that Bryant confessed to the theft.5 Bryant offers no evidence to demonstrate why Chartwells' explanation that it relied on this evidence for termination is pretext. Therefore, there is no legally sufficient evidentiary basis for a reasonable jury to find that Chartwells unlawfully terminated Bryant in retaliation for filing an EEOC charge of discrimination.

15
Bryant also asserted several theories to demonstrate that Chartwells' true "motivating factor" behind its decision was Bryant's race. First, Bryant argues that there was a conspiracy between the Hispanic employees—Saldana, Madrigal, and Ortiz—to get him fired and that


district court concluded, in denying Chartwells' JMOL, that Bryant established disparate treatment since he and Ortiz were similarly situated employees in the minds of the jury, both being "among the low level hourly employees." The district court stated that

20
There was evidence that Max Mitchell, [Chartwells'] food director at Lamar at the time, and one of the three individuals who made the decision to fire Bryant, had been aware that Ms. Ortiz, a Hispanic, had pilfered food, alcoholic beverages, and/or table decorations. No action was taken, and [Chartwells] presented no credible evidence that Ms. Ortiz did not do these things, that any disciplinary action was administered, or that there was good reason for not administering disciplinary action. On the other hand, Bryant, who in [Chartwells'] view, was a similar,of production then shifts to the defendant to establish legitimate non-discriminatory reasons for its actions. The plaintiff then bears the burden of persuading the trier of fact by a preponderance of the evidence that the employer intentionally discriminated against the plaintiff because of the plaintiff's protected status. Laxton v. Gap Inc., 333 F.3d 572, 578 (5th Cir.2003).

4
 Bowden testified at trial that Bryant never directly admitted to him that he took the cards or money:
Q: Lt. Bowden, I thought you told me that Mr. Bryant didn't admit to taking the money?
A: The words "I did it," no, you're right, he never said that.

5

Q: What did you tell Mr. Mitchell?
A: I told Mr. Mitchell that Brandon agreed to pay back the money.
Q: What else did you tell Mr.


..and, um... "moon" because it was the first time... ..a husband got to see his wife's bottom." "What's happening?" "I have to go." " Where?" " America." "That is a tragedy." "Just before I go,... ..when were you thinking of announcing the engagement?" "Sorry." "Whose engagement?" "Ours." "I assumed since we slept together and everything, we'd be getting married." "What did you think?" "W-w-w..." "I, um..." "Gosh!" "You know, that... that, um... ..takes a lot of thinking about, that kind of thing." "Obviously, I'm..." "I, um..." "You're joking." "God!" "For a moment there, I thought I was in FatalAttraction." "You were Glenn Close and I was gonna find my pet rabbit on the stove." "No." "But I think we both missed a great opportunity here." "Bye." "(door closes)""(alarm rings)" "(Charles) Oh, fuck!" "(Scarlett) Mm?" "Fuck!" " Fuck!" "Fuckity fuck!" " Oh, fuck!" " Car or taxi?" " Taxi." "We could never park." "Car seems a good idea." " Fuck!" " Fuck!" " Hey..." " Leave it." "No one will notice." "Well..." "Sorry I'm late." "Traffic." "Yeah..." "Who is it today?" "(photographer) One more, please." "They're ready." "( Handel "The Arrival of the Queen of Sheba")" "In the name of the Father and of the Son and of the Holy Spirit." " Amen." " (all) Amen." "Let us pray." "Father, you have made the bond of marriage a holy mystery,... ..a symbol of Christ's love for his church." "Hear our prayers for Bernard and Lydia... ..through your Son, Jesus Christ our Lord,... ..who lives and reigns


love, they live together, and one day they run out of conversation." "Totally." "They can't think of a single thing to say to each other." "That's it!" "Panic!" "Then suddenly, it occurs to the chap that there is a way out of the deadlock." " (Charles) Which is?" " He'll ask her to marry him." "Brilliant!" "Brilliant!" "(Gareth) They've got something to talk about for the rest of their lives!" "So it's just a way out of an embarrassing pause in conversation." "The definitive icebreaker!" " Tom!" "How's the speech coming along?" " It's pretty good, I think." "Something for everyone." "Tears, laughter..." " Excellent!" " It's a very good theory, Gareth." "There is another argument, of course, that it has something to do with true love." "Well,today?" "Oh, yeah..." "I'm taking advantage of the fact that, for the first time in my entire life,... ..it's Saturday and I don't have a wedding to go to." "All I have to do is not be late for David." "I was going to go for a job." "This new shop called Spank wants a sales assistant." "I think I'd be great." " They sell all this funny rubber stuff." " Oh, no!" "Another wedding invitation... ..and a list." "Lovely!" "They say rubber's mainly for perverts." "Don't know why." "I think it's very practical, actually." "You spill anything on it and itjust comes off." "That could be why the perverts like it." "You all right?" "Yeah, yeah." "It's that girl, um..." "Carrie." "You remember the, uh..." "The American."


course not easily forgotten, was kinda nice." " Two... hairy back." " (Charles chuckles)" "Three, four, five..." "Um, six... was on my birthday in my parents' room." " Which birthday?" " 17th." " We've only reached 17?" " I grew up in the country." "Lots of rolling around in haystacks." "OK." "Seven..." "Mmm..." "Eight... unfortunately, was quite a shock." "Nine, against a fence." "Very uncomfortable." "Don't try it." "I won't." "10, oh... was gorgeous." "Just heaven, just..." " Oh, he was wonderful!" " I hate him." "1 1 , obviously after 10, disappointing." "12 through 17, the university years." "Sensitive, caring, intelligent boys." "Sexually speaking, a real low patch." "Um... 18... broke my heart." " Years of yearning." " I'm sorry." "20..." "Oh, my God!" "I can't believehubby?" " Bugger off, Tom." " Quite right." "A toast... before we go into battle." "True love." "In whatever shape or form it may come." "May we all in our dotage be proud to say "I was adored once, too."" " True love." " (all) True love!" "Apparently, a-a-a-an enormous number of people... ..actually bump into their future spouses at weddings,... ..w-w-w-which is interesting." " Yes, I met my husband at a wedding." " Ah." "Good Lord, I seem to have finished my drink." "If you'll excuse me." "Hello." "My name's Scarlett." "Named after Scarlett O'Hara, but much less trouble." " What's your name?" " My name's Rhett." "No..." " Not really?" " No, not really." " In fact, it's Chester." " You kidder!" "I always imagine Americans


of Water' Dildo: We Just Spoke With the Creator of the Amphibian Man-Inspired Sex Toy

Though she’s sold out again, Ere could probably be talked into whipping up another batch.

Asked by email if the demand has grown even more since the film’s big wins last night, Ere responded: “A pretty good amount!”

Yeah, she’s excited — and so are her clients.

Also Read: Guillermo del Toro Has Seen That 'Shape of Water' Dildo - It's Not Accurate

Now, Ere just wants to thank her hero del Toro and actor Doug Jones, who played The Asset, by sending them a gift. “No, not a fish dick,” she said, “but a coaster set and maybe a teeny gold replica.”

Careful about that “teeny” thing, Ere. Men — even fish men — are sensitive. But hey,HARRY HERKOWITZ, by LYNDA
A. GLASSER, Personal Representative,

               Defendants,

and

SOUTH OAKLAND ANESTHESIA
ASSOCIATES, PC, also known as AMERICAN
ANESTHESIOLOGY OF MICHIGAN, PC, and
RANDY J. FAYNE, D.O.,

               Defendants-Appellees.

Before: SERVITTO, P.J., and CAVANAGH and FORT HOOD, JJ.

PER CURIAM.

       Plaintiff appeals as of right an order granting summary disposition to defendants South
Oakland Anesthesia Associates, PC, (an assumed name for American Anesthesiology of
Michigan, PC) and Randy J. Fayne, D.O. (collectively, “defendants.”) The court subsequently
denied reconsideration. We reverse and remand for further proceedings.

       On December 13, 2011, plaintiff underwent a lumbar laminectomy at William Beaumont
Hospital and Fayne


‘but for’ negligence this result does not ordinarily occur, “even if it is disputed,” “the jury is
to determine whether plaintiff has proven whether it is more likely than not that defendant’s
negligence caused plaintiff’s injury.” Id. at 154-155. Moreover, “[w]here the conditions for res
ipsa loquitur are met, the doctrine also serves to link the defendants with the negligent act[.]” Id.
at 158 n 15.

        Here, defendants challenged plaintiff’s ability to establish a prima facie case under his res
ipsa loquitur theory primarily on the grounds that the evidence was insufficient with regard to the
first and second conditions of the doctrine. First, defendants argued that plaintiff failed to show
that his injury was of a kind that “ordinarily does not occur in the absence of someone’s
negligence.”   persuades the trier of fact not to draw such inference or which so overcomes the
       inference that the court concludes it would no longer be reasonable for the trier of
       fact to draw the inference. [Id. at 374 (footnote omitted).]

The Hand Court recognized the possibility that a visitor, rather than an employee, was
responsible for the burns:
       True, visitors were allowed and it is possible that the injury was caused by the act
       of someone other than one of defendant’s servants. However, the absence of
       exclusive control does not necessarily preclude an inference of negligence in


myself, to the best of my knowledge what happened after that, we struggled for awhile in the middle of the street, we got in the middle of the street, Mr. Landegren went down with one hand, he wasn't down altogether, anyhow, maybe I am excited I don't know, but I try when he is down to help him up thinking everything is all over. When he is up, the worst names any man can call in front of a wife and mother, that is Mr. Landegren. Then we started again, maybe I follow him, maybe I don't, I don't remember exactly what happened, I was excited. Just about the time I got across the *216 street, Mr. Landegren laid one on my forehead right here, pretty hard, knockedit because I'm a 'Contributor' and not 'Owner'?
Thanks!

A:

With latest changes made on the dev.botframework.com portal, now you can select the target directory when migrating a bot to the Azure Bot Service.
For me, the target directory selected by default was the one that doesn't have a valid Azure subscription. But now I can select the other target directory, that has the valid subscription, and finish the migration process.


There was a significant linear association between RVEDVi and LVEDP (p = 0.05). RV end-diastolic pressure (p <0.001), right pulmonary artery systolic pressure (p = 0.009), left pulmonary artery systolic pressure (p = 0.02), and total cardiopulmonary support time (p = 0.04) during TOF repair were also significantly associated with LVEDP. Compared to patients with LVEDP <12 mm Hg, those with LVEDP ≥12 mm Hg had significantly higher mean RVEDVi (135.2 ± 47.8 vs 98.6 ± 28 ml/m(2), p = 0.007) and mean RV end-diastolic pressure (11.7 ± 1.6 vs 8.5 ± 2.8 mm Hg, p = 0.0003). In conclusion, after TOF repair, LVEDP is significantly associated with RVEDVi. Furthermore, mean RVEDVi is significantly higher in patients with LVEDP ≥12 mm Hg. These findings support the theory thatgames in a season twice in his four years in the NFL. Being injured so frequently made it tough for him to develop his natural tools and it wasn’t until 2016 that Ingram finally got his feet under him.

Ingram lined up in one position on nearly every pass rush attempt he took. However, he was fairly evenly split between lining up on the left and right side of the offensive line. There’s not much to glean from where Ingram lines up. The Chargers used him in a pretty vanilla fashion as a 3-4 outside linebacker. However, it should be noted that San Diego defensive coordinator John Pagano had Ingram drop into coverage far too often, at least over the first half of the season, for my liking and


it shows up in his splits for the season’s first and second halves. Always let your best pass rusher focus on rushing the passer.

By all measures, Ingram had an incredible 2015 season. He had been swiftly labeled a bust after his first three seasons in the NFL, over which he combined for 6 sacks in 29 games. Finally, four seasons into his career, Ingram seems to have figured it all out. His ability to beat his blocker, pressure the quarterback, and bring him to the ground were all exceptional in 2015.

His Pressure Rate of 20.9% is truly elite. Of the limited sample of players I have charted from 2015 Ingram’s 20.9% is the best of the bunch. It’s also the only one above 20%. Being able to directlymethylation plays a role in complex, multi-factor epigenetic regulation of gene expression \[[@B5-cancers-11-01650]\]. According to a generally accepted model, DNA methylation at gene regulatory sites suppresses transcription. Alterations in the methylation pattern, including both addition and removal of methyl groups, affect the cell's gene expression profile and may facilitate the acquisition of tumorigenic potential \[[@B5-cancers-11-01650]\].

Several previous studies performed genome-wide methylation profiling of pituitary adenomas. Some of these reports focused mainly on comparing hormone-secreting vs. non-functioning adenomas. The results revealed that NFPAs are the PA subtype that is most affected by aberrant DNA methylation \[[@B6-cancers-11-01650],[@B7-cancers-11-01650],[@B8-cancers-11-01650]\]. Another study was focused solely on NFPAs and reported a difference in DNA methylation patterns between tumors exhibiting invasive vs. non-invasive growth, a feature of particular clinical importance \[[@B9-cancers-11-01650]\].

Our previous comparison of the DNA


series) is launched to check whether all the theoretical parameters will actually achieve the desired results in practice. Some adjustments may need to be made on detail level to ultimately comply with all the specified requirements. This is then followed by the definitive series production.x-b\right) f\left(
b\right) -\left( x-a\right) f\left( a\right) }{2\left( b-a\right) }-\frac{1}{%
b-a}\int\limits_{a}^{b}f\left( t\right) dt\right\vert  \label{hh} \\
&&  \notag \\
&\leq &\frac{\left( x-a\right) ^{2}+\left( b-x\right) ^{2}}{8\left(
b-a\right) }\left( \Gamma -\gamma \right) \text{, for all }x\in \left[ a,b%
\right] .  \notag\end{aligned}$$

Theorem \[t1\] is a generalization of the following Ostrowski-Grüss type integral inequality, which was firstly by Dragomir and Wang in [\[2\]]{} and further improved by Matic et al. in [@[5]].

\[t2\] Let the assumptions of Theorem \[t1\] hold. Then for all $x\in %
\left[ a,b\right] $, we have

$$\begin{aligned}
&&\left\vert f\left( x\right) -\frac{f\left( b\right) -f\left( a\right) }{b-a%
}\left( x-\frac{a+b}{2}\right) -\frac{1}{b-a}\int\limits_{a}^{b}f\left(
t\right) dt\right\vert  \label{hhh} \\
&&  \notag \\
&\leq &\frac{1}{4}\left( b-a\right) \left( \Gamma -\gamma \right) .  \notag\end{aligned}$$

The above two inequalities are both connections between the Ostrowski inequality [@[3]] and the Grüss inequality [@[4]] and can be applied to bound some special mean


= container_of(inode->i_cdev, struct vp_android_dev, dev);
    filp->private_data = dev;

    return 0;
}

/*设备文件释放时调用，空实现*/
static int vp_release(struct inode* inode, struct file* filp) {
    return 0;
}

/*读取设备的寄存器val的值*/
static ssize_t vp_read(struct file* filp, char __user *buf, size_t count, loff_t* f_pos) {
    ssize_t err = 0;
    struct vp_android_dev* dev = filp->private_data;

    /*同步访问*/
    if(down_interruptible(&(dev->sem))) {
        return -ERESTARTSYS;
    }[Does the authentication of the antibodies against Helicobacter pylori have contribution to its diagnosis?].
Generally, it is possible to use both invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection. One of the non-invasive methods not requiring endoscopic examination of the patient is, besides the breath test and stool antigen test, serological detection of the antibodies. Antibodies are determined in the IgM, IgG and IgA classes using the ELISA method with a sensitivity of 82-96 % and specificity of 67-92 %. Confirmation with the Western blot allows more precise specification of the infection. At the same time, it is possible to identify individual specific antibodies against Helicobacter pylori antigens. It allows determination of antibodies against CagA which is considered an important virulence marker. The study comprised 447


On Monday’s “Hugh Hewitt Show,” Sen. Joni Ernst (R-IA) stated that while she won’t make a final judgment on which witnesses, if any, she wants to call in the Senate’s impeachment trial, doing “investigative work” is not the Senate’s job, and the House had the opportunity to bring in former National Security Adviser John Bolton as a witness and didn’t.

Ernst began by saying, “I have said time and time again, regardless of who the witness is, what the situation was, we need to get through phase one first.”

She added that the House “had every opportunity to subpoena these witnesses. They could have taken the time to go through the court system. They chose not to do that. They were in such an all-fired hurry to get this impeachmenttheir children.

I am hoping and praying that John Tighe is exonerated and NXIVM and its leaders are ground into the dust.

But it is clear, it will not be easy. The present criminal justice system in America, often mistake the criminals with the upholders of the law. In some instances, it might better be called the Criminal’s Justice System. This may be the case with john Tighe, where criminals put an innocent man in prison.

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"raw milk" thing. Now it's decided. I'm in. Now I just need to find an organic
dairy farmer within a reasonable drive who will hook me up.

I have an organic dairy in Missouri. I sell milk to people directly all the time.

I know what they are going to do with it.

They know what they are going to do with it.

However, I have to label it with a sticker that indicates the date and time and that it is not being sold for the purpose of human consumption.

Lots of people here evidently have a lot of "bottle baby" animals that need hand fed. As a herd manager I know that farmers just love to take the
time to bottle feed calves and other orphans.

Admittedly if I thought I'd sell enough todon't know." "I'm a bit jumpy." "I'll make some coffee." "( thunder )" "Want one?" "Sure." "We might as well both get smashed if you're really looking for trouble." "Look, I don't want to have a row." "I really don't." "But I do not like that thing, and I do not like your attitude in completely ignoring that fact." "How can you get so neurotic over a delightful little tree?" "It isn't a tree." "A piece of a tree, a perfectly natural piece of a tree." "It isn't natural." "What do you mean?" "It's unnatural." "It's sawn off and upside-down and ugly." "It's vile." "Don't say we've got to keep it." "You're being ridiculous." "You'll be telling me it's you or her next." "You've been spoiling for a


help me." "And you'll come to supper tonight." "( lounge music playing )" "Kimo, I forgot you don't." "Ginny?" "Hmm." "Perhaps you shouldn't." "Special occasion." "Well, a little, but no more." "I could be jailed for bringing you here." "I didn't realize Ginny was quite so..." "She isn't." "She's still in school." "Come the holidays, out they blossom." "Mother!" "I'm sorry." "We don't talk about our ages." "Either of us." "Ha ha!" "Kimo, I'm so glad you're here." "I've got to work contractual miracles to get you this side of the water." "Have you read Kimo's new book?" "No, but I shall now." "I'm flattered." "I might even ask you to autograph a copy." "For you, I'd be honored." ""To Virginia with much love."" "Wow!" "Why don't youdecision, which cannot be appealed, marks the first time the United States has been cleared under international trade law to slap countermeasures on EU products.

With its Brexit deadline less than a month away, Britain said in a statement that it "should not be subject" to any sanctions.

However, a senior US trade official told reporters the EU collectively bears responsibility for the failure to resolve the subsidy issue, indicating there would be no exemptions.

And the official indicated the other EU member countries that will be hit by tariffs could help convince Brussels to end the subsidies to the aircraft manufacturer.

Counter case

Brussels will also soon get the chance to impose its own WTO-approved tariffs.

In a separate case launched in 2005, the EU alleged that Boeing had received $19.1 billion worth


or bath time—preparing meals together in the kitchen can help you steal a little more time with your kids. The kitchen is warm, the pace relaxed, and the conversation easy. Children are also proud of their culinary accomplishments, exclaiming at the table: “I helped make it!” and then diving into a huge portion of those very same carrots they peeled just minutes earlier. Each recipe includes a list of exactly which steps kids can tackle. In addition, there are tips on how to incorporate healthful ingredients and new flavors into a child’s diet; how to make a kitchen safe for children; and how to pull off a kids’ cooking party. The indispensable companion to every family’s favorite gathering spot, The Family Kitchen has a place in every home.

Cook-A-Doodle-Doo!knowhow to top up? We'll show you how.
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If you’re a Pay as You Go customer, there’s a few ways you can top-up. The quickest way, is by logging in to My3. Just go to “Top-up” and follow the steps. You’ll also be able to register a debit or credit card to make it easier to top-up next time.
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A top is a toy designed to be spun rapidly on the ground, the motion of which causes it to remain precisely balanced on its tip because of inertia. Such toys have existed since antiquity. Traditionally tops were constructed of wood, sometimes with an iron tip, and


speak on “Current Kosher Fish Issues.”

The question and answer session will give priority to questions submitted by fax to 212-613-0621 or email grossman@ou.org. A free copy of the twentieth yearly volume of The Daf HaKashrus, the OU’s highly acclaimed newsletter for kashrus professionals, will be distributed.

For further information, contact Rabbi Grossman at 212-613-8212, 914-391-9470, or grossman@ou.org.
…

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Was 2018 a good year?

We react emotionally to certain stories, and they define the way we look at the world. We neglect many other changes and trends because they don’t fit into the main stories we consume. The world is a very complex system, and transformative change occurs everywhere. How are we doing, from the point of view of pure data? In many ways, life has become much better for many people on this planet. This was pointed out by Hans Rosling in his book “Factfulness: Ten Reasons We’re Wrong About the World–and Why Things Are Better Than You Think.” There is an accompanying website


Fake news meets 18c

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Earlier this month Professor Andrew Jakubowitz of the taxpayer-created Cyber Racism and Community Resilience Research Group attempted to debunk a poll commissioned by the IPA showing a plurality of Australians supported section 18C reform.

As I explained on Flat White, his argument that the IPA was pushing loaded questions fell apart when exposed to minimal scrutiny. Professor Jakubowitz’s CRaCR later commissioned Essential Research to conduct separate polling, culminating in this article by Jakubowitz, Professor Kevin Dunn and Rachel Sharples that appeared The Conversation on 17 February, arguing “an overwhelming majority of Australians support legislation that prevents insults on the basis of race, culture or religion.”

The Parliamentary Joint Committee on Human Rights in its just-released report into 18C even mentioned this poll as a contrast toor religion” is particularly bizarre in light of the fact the wording of section 18C refers to “race, colour or national or ethnic origin”. As even Professor Jakubowitz has explained in 2015, section 18C: “the Racial Discrimination Act does not cover religion. Never has, and clearly is very unlikely to in the future.” In an email, Professor Dunn wrote:

[18C] It does not currently cover with religion. Religious discrimination is defined as racism within social science. Attempts re-frame religious discrimination as not racism are nonsensical.

The “social sciences” may think race and religion are interchangeable, but social science isn’t the law.

In light of all this, one would be wary of using the CRaCR survey as an accurate indicator of public opinion about section 18C.

[The poll] found that well over 75


for use later in court. Even having the phone in your hand at a stoplight is grounds for a ticket.

"It's like an addiction," explained Jouwstra. "If they hear a ping from the phone, or it lights up, [drivers] feel they have to pick it up."

He and other safety experts say people have been told for decades that the ability to multi-task is a good skill to have. Behind the wheel, though, focused attention is essential for safety.

Insurance industry takes aim

Lisa Guglietti, chief operating officer of the Co-operators Group, said that given "all the safety features that are being built into vehicles now, you would actually expect that trend should be coming down."

But over the last couple of years, "we've noticed that the number of collisions we're seeing hasendoscopic and radiological guidance ([Figure 1](#fig1){ref-type="fig"}). Technical success was defined as successful placement of the SEMS across the obstructing lesion with good passage of contrast post stenting. In this series, technical success equated to clinical success and all patients who achieved a technical success had symptomatic relief.

Three patients were excluded at the time of the procedure as stenting was thought inappropriate (stenting was not attempted). One patient had a pre-existing perforation demonstrated with contrast and preceded with operative intervention. Endoscopy and radiological studies failed to detect an obstructing malignant lesion in the other two patients, and stenting was not performed.

This paper analysed the resulting 37-patient case series. To aid with analysis and to show a change in practice over time, the series was divided chronologically in half (1st


subordination {#s2c}
------------------------------------------------

As stated earlier, the results from the narrative review suggest that two professional groups are commonly found at the centre of any primary care delivery model: physicians and nurses. However, despite its seemingly dichotomous nature, we argue this characteristic of primary care models should be conceived on a continuum of professional autonomy and subordination.[@R33]

Historically, the medical profession has been very successful at claiming and protecting a monopoly over the provision of most human healthcare. However, to deliver the care while relying on a relatively scarce workforce, the medical profession has delegated a significant portion of the day-to-day work to 'subordinate' professional groups, among which nursing is the most important.[@R34] For members of those historically subordinated professions, practical professional autonomy is highly dependent on the level of subordinationnew members (systematic socialisation for all new entrants).   Work within the team is structured according to formal teamlets (yes=2, yes, but with flexibility=1, no=0).

For the autonomy/subordination scale, we mostly relied on the work of Adamson *et al* [@R40] and Hojat *et al*.[@R41] In those two scales, we selected items based on two criteria. First, an item had to have obvious conceptual ties with the concept of subordination in primary healthcare delivery. Second, the item had to be focused on actual practices or processes rather than on perceptions. [Table 2](#T2){ref-type="table"} presents the selected criteria from Adamson *et al* [@R40] and Hojat, *et al* [@R41] and how we operationalised them.

######

Operationalisation of the measure of nurses' autonomy versus subordination

  From Heinemann *et al* [@R53]


analysis of each practice setting also suggested teams have a great deal of agency in articulating their model of practice. We understand this as suggesting that, unless formalisation is pushed to extremes in any given direction, autonomy/subordination remains a dimension over which teams can have significant control.

However, according to a contingency theory approach, the optimal level of formalisation is not something organisations can fully decide on their own. There are parameters (eg, size, age, environmental predictability, managerial style, etc[@R18]) that set a range of plausible levels. And indeed, the rough measure of organisational size we applied did correlate with our measure of formalisation. This suggests there would be some merit in conceptualising primary care teams' structural and process optimisation in a systemic way. The optimal choice for any giventeam is likely to be contingent on a set of interconnected parameters. For example, if team size is indeed positively associated with formalisation and, in turn, if high levels of formalisation tend to limit nurses' autonomy, then team size and nurse autonomy should be seen as interdependent. Such an observation is especially timely given that the current trend towards a more diverse and interprofessional workforce in primary care goes hand in hand with increasingly large practice size.[@R7]

Similarly, given the results obtained, we believe that if a primary care team aims to increase nurses' and other non-physicians' professional autonomy, it should be very careful about the extent to which it formalises its processes. This advice is also worth considering in relation to the avalanche of recommendations in the nursing


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           qty; ++i) {
            blocks.add(block);
            block = this.blocks.get(block.getParentHash());
            if (block == null) {
                break;
            }
        }

        return blocks;
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        Block bestBlock = getBestBlock();

        long maxLevel =


               rlpBlockInfoList.add(RLP.encodeList(hash, totalDiff, isMainChain));
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            return RLP.encodeList(elements);
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                }
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I was learning in yeshiva. A non-Jewish friend came to visit me and asked to see the Beit Midrash. So I put a yarmulke on his head and told him to come in. He expected a large hall with all the students whispering, like in a university library. But what did he encounter? Three hundred young fellows walking around nervously, shouting at each other as if the world was coming to an end.

In total shock, he asked me. “What is this, a demonstration against the Queen of England?” ”No,” I said, “they are discussing what God actually said three thousand years ago at Mount Sinai.” “You still don’t know?” he asked. “No,” I said. “Indeed, we still don’t know, and that’s why we are still alive after fourus to play on our souls. Strict notes, but to be played with infinite passion. To listen to Bach is like being struck by an uppercut under the chin and staying unconscious for the rest of the day. And so it is with the Torah. It is like an archeologist forced to go to rock bottom in search of all the hidden possibilities; to exert himself in order to unearth them and find infinite treasures.

God owes a lot to Bach. He put God in the center of our world. Where would God be without Bach?

But Bach’s music is more than that. It is a rebellion. A rebellion against all earlier forms of music. Against making music sterile, stagnated, boring and flat. It opened new dimensions that people did


the noxious components used previously, including oxidants, reductants, and acidic solvent (e.g., ammonium persulfate, (APS), sodium borohydride, and HCl, respectively). The omission of APS, which is the second highest-priced component among the materials, could further reduce the total manufacturing cost. In this study, the aniline, Fe precursor, and carbon support were simply mixed under ultrasound irradiation in one pot for direct reaction. It is supposed that ultrasound plays two kinds of roles. It could affect the crystallinity and structure of polyaniline which might have something to do with the active sites after a pyrolysis^[@CR24]^. In addition, it is able to reduce the polymerization time and cause an abrupt nucleation throughout the solution^[@CR25]^, which can help forming uniform and homogeneous distribution of active sites for ORR. The conceptual diagramnon-precious metal catalysts for the ORR.

Methods {#Sec7}
=======

Synthesis of Fe-PANI-K {#Sec8}
----------------------

Iron(III) chloride hexahydrate (FeCl~6~·6H~2~O) (0.5 g), aniline monomer solution (10 mL, Sigma-Aldrich) and carbon black (0.1 g, AkzoNobel, Ketjen black EC-300J) were mixed together with vigorous stirring for 30 min and then purged with argon for an additional 30 min. The mixture was treated with ultrasound for 3 h at 10 °C using an ultrasonic generator (Branson, 20 kHz, 100 W cm^−2^). After ultrasonic treatment, the mixture was left overnight at room temperature. The Fe-PANI-K was separated from the mixture by centrifugation for 30 min (Labogene, 1236 mg). The isolated Fe-PANI-K was dispersed in ethanol (Daejung, 94.5%) and filtered through filter paper (membrane filter, ADVANTEC, cellulose acetate 0.45 µm) to remove any residual aniline and iron precursors. The filtered Fe-PANI-K was perfectly dried in air.

Post-treatment of Fe-PANI-K {#Sec9}
---------------------------

The post-treatment process comprised three


and let's me play my game."

5. What is your favorite food?

"I love salmon, broccoli and mashed potatoes."

Starr Breedlove at FAU Arena. (Photo by Brandon Cohn)

6. What are your thoughts on being nationally ranked, currently UTEP is 33rd in the nation.

"It's amazing, it gets tougher and you always need to be focused no matter what team you are on. This is even better for me because I'm part of it, when I was at Louisville I wasn't playing all that much, so this is special."

The Miners will continue their journey during this remarkable season as they look to go 15-1 tonight at FAU. You can listen to the game at 5 p.m. MST on 600 ESPN El Paso with the Iceman Brandon Cohn.QtGui.QPushButton('button to add other widgets')
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Helen Bouchard
 10th - Brigita Brezovac
 11th - Zoa Linsey
Comparison to previous Olympia results:
Same - Iris Kyle
+3 - Yaxeni Oriquen-Garcia
Same - Debi Laszewski
+3 - Dayana Cadeau
+6 - Heather Foster
+1 - Cathy LeFrançois
+2 - Tina Chandler

Scorecard

Attended
13th Ms. Olympia attended - Yaxeni Oriquen-Garcia
12th Ms. Olympia attended - Iris Kyle
11th Ms. Olympia attended - Dayana Cadeau
4th Ms. Olympia attended - Cathy LeFrançois
3rd Ms. Olympia attended - Heather Foster
2nd Ms. Olympia attended - Debi Laszewski and Tina Chandler
1st Ms. Olympia attended - Zoa Linsey, Brigita Brezovac, Helen Bouchard, and Sheila Bleck
Previous year Olympia attendees who did not attend - Heather Armbrust, Betty Viana-Adkins, Rosemary Jennings, Heather Foster, Nicole Ball, Gale Frankie, Kristy Hawkins, Betty Pariso, and Lisa Aukland

Notable events
This was Iris Kyle's 6th overall and 5th consecutive Olympia win, thus tied- 85996 - 1840138 = 0. What is the hundreds digit of u?
0
Let p(j) = 2*j**3 - 6*j**2 - 3*j + 16. Let k be p(3). Suppose k*x = 2*x, 4*o = -3*x + 352. What is the tens digit of o?
8
Suppose 179*s + 358706 - 5408117 = 0. What is the thousands digit of s?
8
Suppose -2*g = -16 - 2. Suppose 0 = 16*o - 13*o + g. What is the tens digit of -1 + ((-309)/o - -4)?
0
Suppose -7*u - 727 = -2*u + b, 8 = -4*b. Let g = u + 337. What is the hundreds digit of g?
1
Let m(k) = -23*k - 334. Let o be m(-14). Let a(v) be the third derivative of -5*v**4/24 + 31*v**3/6 + 2*v**2. What is the units


or do we want to do something else?"

'Spectacular finale'

The creators of Merlin say this series is where the storylines have reached their peak.

"We always felt the story of the legend was best told across five series, leading to a spectacular finale that draws on the best-known elements of this much-loved story and brings to a conclusion the battle for Camelot."

Richard Wilson plays Merlin's mentor in the show and admits while he is extremely sad the show is ending thinks it is good news for his character.

I think the show has run its natural course. We've arrived at its strongest point and we've achieved what we set out to do Colin Morgan Merlin

"Speaking as Gaius I feel I have mentored the young wizard as far as I can. Heother additional charge involves the video Magnotta allegedly posted on the internet, in which he is believed to be the person depicted dismembering a body. The charge is part of a section of the Criminal Code called “corrupting morals.”

Police confirmed Friday the murder was committed on the night of May 24 to 25, and that Magnotta flew out of Montreal on Saturday, May 26, to Europe.

Lin’s torso and the foot and hand mailed to the federal Conservative and Liberal parties were discovered Tuesday.

Police would not confirm several reports that Magnotta flew into France, saying they did not want to limit the scope of the investigation.

Concordia University officials identified Lin as an undergraduate student in the engineering and computer science faculty, but would release no other details, citing privacy


About what?" " About what she did to your window." "Bridgette, I explained that to you last night." "But, she is right there!" "I know but, honey I can't accuse someone just because you saw something in the dream." "But, I saw her, daddy!" "." "She took a rock and smashed your window with it." "Ah, maybe she did and maybe she didn't." "But, I still can't accuse someone just because you saw it in the dream." "Now, give me a kiss." "Come on." "Talk some more tonight." "Michael?" "You look exactly how I imagined." " Under watch, isn't he?" " I'm sorry?" "This charade, I know my mother's paying good money for it." "I swear if my dad were still alive." "He'd have this guy out ofseeing Gregory King." "Oh." "Hello?" "It's Scanlon." "He's right here." "They picked up Henry Alonso." "He was high as a kite." "He pawned a 5 carat diamond ring, and a diamond face watch." "Both stolen from Gregory King the night he died." "Yeah, he is smiling." "Ok." " Hey." " Yes!" "How did it go?" "She's still mad at me.?" "Well, she still thinks what she had dreamt was a truth, so I guess so." "How about our fourth child?" "The big lump living on the couch?" "He fell asleep watching TV." "Fell asleep or passed out?" "I'll have you know he didn't drink anything stronger than orange juice today." "Geez" "The guy cracks one lousy murder case and suddenly he's the poster child for sobriety" "Hey!" "He


summary judgment if the evidence would allow a reasonable jury to return a verdict for the non-movant.  Anderson v. Liberty Lobby, Inc., 477 U.S. 242, 248 (1986).  "Although we consider the evidence and all reasonable inferences to be drawn therefrom in the light most favorable to the nonmovant, the nonmoving party may not rest on the mere allegations or denials of its pleadings, but must respond by setting forth specific facts indicating a genuineissue for trial."  Rushing v. Kansas City S. Ry. Co., 185 F.3d 496, 505 (5th Cir. 1999), petition for cert. filed (Dec. 28, 1999) (No. 99-1090).

III.  Analysis

18
In this case, appellants assert several grounds upon which summary judgment was improper.  As their primary objection, appellants assert that an oral contract existedasserted renders summary judgment inappropriate.  Each claim, and why it ultimately fails to override our understanding of the plain terms of the SERP agreement, is addressed below.

B.  Oral Contract

26
It must be made clear that this is not a dispute about whether appellants are entitled to their benefits.  The RTC concedes that the SERP benefits at issue were fully vested and are in fact owed appellants as unsecured general creditors.  In fact, appellants received certificates representing their respective interests.  The critical dispute between the RTC and appellants in this matter concerns the determination of exactly what was bargained for in this case: the maintenance of the SERP and Umbrella trust agreements as they existed prior to conservatorship, or additional contract rights, bargained for to


creditors for the benefits of favorable tax treatment-a gamble which failed to pay off in this case.").

39
Furthermore, the relevant statutes make clear that the receiver, not the conservator, "has the authority to liquidate the assets and pay the obligations of the insured institution on behalf of the depositors and creditors."  RTC v. Cheshire Management Co., 18 F.3d 330, 333 (6th Cir. 1994).  See also RTC v. CedarminnBldg. Ltd Partnership, 956 F.2d 1446 (8th Cir. 1992).  Pursuant to this authority, "[t]he RTC receiver liquidates an institution and distributes its proceeds to creditors according to the priority rules set out in regulations."   Del E. Webb McQueen Dev. Corp. v. RTC, 69 F.3d 355 (9th Cir. 1995).

40
It is inconceivable under the relevant law that the ConservatorFILE_READ_ACCESS | FILE_WRITE_ACCESS)
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  CTL_CODE(MOUNTMGRCONTROLTYPE, 8, METHOD_BUFFERED, FILE_READ_ACCESS)
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  CTL_CODE(MOUNTMGRCONTROLTYPE, 9, METHOD_BUFFERED, FILE_READ_ACCESS | FILE_WRITE_ACCESS)
#define IOCTL_MOUNTMGR_CHECK_UNPROCESSED_VOLUMES \
  CTL_CODE(MOUNTMGRCONTROLTYPE, 10, METHOD_BUFFERED, FILE_READ_ACCESS)
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  CTL_CODE(MOUNTMGRCONTROLTYPE, 11, METHOD_BUFFERED, FILE_READ_ACCESS)
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  CTL_CODE(MOUNTDEVCONTROLTYPE, 2, METHOD_BUFFERED, FILE_ANY_ACCESS)

#define MOUNTMGR_IS_DRIVE_LETTER(s) ((s)->Length == 28 && (s)->Buffer[0] == '\\' && (s)->Buffer[1] == 'D' && \
                                     (s)->Buffer[2] == 'o' && (s)->Buffer[3] == 's' && (s)->Buffer[4] == 'D' && \


to create a more masculine appearance is not going to make a woman into a man. It will merely result in a mutilated woman—a situation that may please the person who undergoes such “therapy” but does nothing to change the foundational facts.

Someone might point out, of course, that the basketball player feels as though she ought to be a man, and intends to change her body to match her feelings; at that point, the female will become a male. Yet even were one to accept the claim that such a mutilated woman is a man, that is not the situation now. The claim is that she is a man in a woman’s body right now, truly a male with a female appearance, a he instead of a she.

Atbe called a man, even though there is no anatomical reason to do so, a place really searching for the truth would have said, “No, we are not going to do that. The truth is on the line. You are not a man—or a dog, or a tree, or the President, or Joan of Arc—despite what you feel or desire. Perhaps, instead, we could do some research to try to help you find out why you feel this way, and how your desire to be a man has emerged.”

The news media, meanwhile, exist to ferret out the facts that are essential for the making of decisions of import to the common good or in the individual lives of its readers and listeners. Thus, it is perhaps even more


not mention any restrictions on the use of the GPS devices.

As a result of signing on to the use of GPS in police vehicles, patrolmen will receive a .25 percent increase in their base pay retroactive to last July 1.

That increase is in addition to others called for in the contract, which covers July 1, 2012, to June 30, 2015. During the life of the contract, union members will see their pay raise by at least 7.25 percent.

In fiscal 2013, which began last July 1, officers will get a 1.5 percent salary increase. In fiscal years 2014 and 2015, union members will receive 2.5 percent salary increases.

The other .5 percent increase in pay over the three years comes as a result of the union agreeing to changes governingan officer could perform light duties would have to be supported by a physician specializing in the officer’s type of injury or illness.

The Superior Officers agreed to the same changes in the contract they signed with the city last year.

Another provision of the Patrolmen’s Union deal matching the Superior Officers’ pact is the stipulation that new members will no longer to be able to buy back a percentage of their accumulated sick leave or buy back five sick days per year.

Patrolmen’s Union members will also receive a $500 signing bonus that will not be added to their base pay.

Moses estimated the contract will cost the city about $320,000 in the first year, which the city can pay for with the $1 million set aside in the current fiscal


oxide ceramic deposition.
The alkaline earth metal and metal complexes bound in a cold trap or another suitable deposition system after the cleaning can advantageously be used for recovery of starting materials for oxide ceramic deposition. To this end, the complexes are separated from one another in a suitable manner, concentrated and purified, forming so-called precursor compounds, such as, for example, diketone complexes with barium and strontium. Since the cleaning of the interior walls of the reactor essentially utilizes the reverse reaction to oxide ceramic deposition, the volatile alkaline earth metal and metal complexes formed are thus already the starting materials for oxide ceramic deposition or can easily be converted thereto.
A dry etching medium is preferably used, i.e. the etching medium is in a gaseous form.
Other features which areconsidered as characteristic for the invention are set forth in the appended claims.
Although the invention is illustrated and described herein as embodied in a process for cleaning CVD units, it is nevertheless not intended to be limited to the details shown, since various modifications and structural changes may be made therein without departing from the spirit of the invention and within the scope and range of equivalents of the claims.


of themselves. The program is open to any member of the community and lasts around 6 months. Woman learn skills in arts and crafts, jewellery making, housework and needlework and men are equipped with knowledge of welding, building and woodwork. Upon completion each member receives a certificate showing their ability in the specific training area and stating their completion of the course.

Cheeky Cheetah Kids Project
When the Van Der Merwe family were looking for schools for their own children, they realized that they had the ability to provide the basic education and general skills for not only their own, but for many of the San people that they employ. The Cheeky Cheetah day care center was established to provide the children day care with the necessary education, food andKerry, also got closest in New Hampshire, but ultimately dropped out mid-way through the primaries.

Of course, Scala did note one “unusual candidate’’ who, after narrowly losing to Clinton in New Hampshire, was able to unite a coaltion of progressives and black voters.

That candidate, of course, was Barack Obama.

2016 presidential candidates


commuting. This involved finding “park and ride” lots at varying distances from the office, a little further each week. Which led to a big leap around mid-summer; from park-and-rides in Saint Louis Park, seven miles from the office, to having to ride all the way across Minneapolis (where there are no park and rides), and do the whole 16 miles.

Which, at long last, I did – once. I rode 16 miles to work in the morning. And then I rode home that night. And as I got to the top of the long, grueling climb up Marshall Avenue, two miles from home, I got a call – my son was in the ER, the beginning of a three month ordeal that had me at the hospital most evenings,his arm in six places and fractured his eye socket, hand and shoulder blade in what he called a “freak accident” in New York.

Ow. Ow. Ow. Ow.

At the time, the hospital where Bono was being treated said he had been involved in “a high-energy bicycle accident when he attempted to avoid another rider”…The 54-year-old Dubliner revealed he now had a titanium elbow.

Ouch. Ow. Owwwww.

Irish singer-songwriter Bono and his band U2 pictured in Berlin late last year

Bono said he “blanked out on impact and have no memory of how I ended up in New York Presbyterian with my humerus bone sticking through my leather jacket. Very punk rock as injuries go”.

Aaaagh. Owww. Ow. Owwwwwwww.

Bono continued: “Recovery has been more difficult than I thought. As I write this, it is


seeing this as an investment, not an expense,” says Pasiuk.

And there you see the spread; cities that are broke, or cities that are doing well enough that they can afford some of the petty luxuries like, well, biking coordinators.

It’s an odd set of priorities for a city that’s flirting with “broke”.

I had to mention this:

And then there’s the health savings. Researchers in the Netherlands found that despite being at higher risk for injury, cyclists enjoy “substantially larger” health benefits compared to drivers.

UPDATE: I changed the reference to MN Energy News in the first graf; it’s “Funded by”, rather than “a front for…”, the pressure group. It was pointed out to me – civilly, mind you – that the phrase “front” casts an unnecessary aspersion. I’ve reworded accordingly.

The badSons of Liberty’s departure from AM1280 – but the General Manager who lets us use his air time, Ron Stone, did, right here, and I really don’t need to add much to that. Of course I will add that much of the Twin Cities leftymedia’s “coverage” of Dean was really, really bad; he never advocated killing gays, for starters, and his “association with the GOP” is even thinner gruel. But hey, they need to break eggs to make omelettes, right?

“But Merg! You lost! Hahahahahahaha!” Well, as Abraham Lincoln said, “The probability that we may fail in the struggle ought not to deter us from the support of a cause we believe to be just.” And bringing a multi-party democracy to the “progressive” cesspool that is Saint Paul is


single nation in the world, really. Even in countries where biking isn’t the most affordable means of transportation for the regular schmuck, bikes are more common among adults everywhere.

While kids sit at home texting their friends and slaying computer-generated monsters, a growing number of their parexnts and grandparents are clogging the roads atop a contraption that was once considered a child’s toy.

Well, no.

The bike became a mass-market commodity item long before the automobile became affordable to most Americans. In many places, the bike was the first ticket the working stiff had to get off mass transit or quit walking, in those days before cars (and manufacturing jobs) became ubiquitous. In some parts of the country, the move to build paved roads was driven initially by the number ofbikes and cars can share the road better – but that’s the subject of a different post.

Recklessness and lawbreaking notwithstanding [Indeed, utterly logically unconnected – Ed.], Big Bicycle has attained the status of a lobby that cannot be ignored. “Bikes Belong,” an agitprop shop “sponsored by the U.S. bicycle industry with the goal of putting more people on bicycles more often,” boasts of “12 professional staff, 18 volunteer directors, and a $2 million annual operating budget.”

As a conservative, I personally am fine letting companies (and groups of companies) spend their own money their own way.

“Maximizing Federal Support for Bicycling,” a page on the organization’s website, explains that it spent $1 million on lobbying between 2002 and 2005, which ultimately produced “$4.5 billion for bicycling and walking in SAFETEA-LU,


immune dysfunction syndrome, neuroendocrine immune dysfunction syndrome, post viral syndrome, Iceland disease, neurasthenia, and Royal Free disease, among others \[[@B5]\].

The various criteria established in recent years have allowed a more accurate delineation of CFS, and this has contributed to a better understanding of its clinical picture, and potential therapeutic interventions \[[@B1]\].

CFS is, therefore, a complex, chronic disorder of unknown aetiology, characterized by the presence of intense and disabling fatigue (physical and mental), with a clinical course and without any apparent cause, which interferes with daily activities, does not decrease with rest, worsens with exercise, and is usually associated to systemic, physical and neuropsychological manifestations \[[@B6],[@B7]\].

The aetiology, diagnosis and therapeutic options for chronic fatigue syndrome in adults and pediatric patients are discussed below.

The aetiology and the pathogenic mechanisms ofQ:

How to format a flash drive to fat32

So I'm kinda stranded after accidentally wiping out my whole internal storage.
I'm trying to install a temporary ROM e.g CM on it via USB OTG on TWRP.
My phone doesn't have an OS on it. I have no PC with me since I'm on holiday.
I tried downloading the 200 meg CM and found a flash disk lying around.
However it has the Xbox fuse file system on it, which TWRP is not picking up. All I have access to is my Android tablet.
So I'm trying to find some sort of file manager that allows the disk to be formatted. Any leads?

A:

You could try any of the following:

The Android pendant (port) of GParted for Linux, AParted. It currently does not support the exFAT file


 digit of ((-1 - -2) + 0)*v?
3
Let r(y) = -2*y**2 - 6*y - 5. Let b be r(-3). Let p(t) = t**2 - 9. Let s be p(b). Let c = s - -8. What is the tens digit of c?
2
Let w(i) = 339*i**2 - i + 2. Let t be w(1). Suppose 597 = 3*x + 5*c, -5*c - 937 = -3*x - t. What is the hundreds digit of x?
1
Suppose 2*j + 4522 = 5*p - 8915, -3*p + 2*j = -8059. What is the hundreds digit of p?
6
Let k(y) = -y**3 + 10*y**2 - 9*y - 14. Let i be 0 + 31/4 - (-2)/8. What is the tens digit of k(i)?
4
Suppose -1375 = -p - 3*x, -3*p = -3*x - 3170 - 991.- k**2 - k. Let t(d) = 3*d**3 + 3*d**2 - 4*d - 5. Let f(m) = w*c(m) + t(m). What is the units digit of f(-4)?
9
Let y = 6 - 3. Let d(s) = 2 + y*s - 11 + 0*s. What is the tens digit of d(7)?
1
Suppose 0 = -4*m + 4*s + 580, -3*m = s + 3*s - 428. What is the units digit of m?
4
Suppose -5*h + 0*w + 5726 = -3*w, 5*w = -4*h + 4566. Suppose 13*p - h = 5*p. What is the tens digit of p?
4
Let j(d) = 2*d**2 - 9*d. Let l(o) = -o**3 - 6*o**2 - o - 13. Let n be l(-6). Let s be (-1)/n + (-82)/(-14). What is the units digit of j(s)?
8
Let u


CHECK_STEP_SESSION_EXITED
  | CHECK_STEP_CHECK_COMPLETE
  | CHECK_STEP_BAD_ROBOT_CALIBRATION
  | CHECK_STEP_NO_PIPETTES_ATTACHED

export type RobotCalibrationCheckPipetteRank =
  | CHECK_PIPETTE_RANK_FIRST
  | CHECK_PIPETTE_RANK_SECOND

export type RobotCalibrationCheckInstrument = {|
  model: string,
  name: string,
  tip_length: number,
  mount: string,
  tiprack_id: string,
  rank: RobotCalibrationCheckPipetteRank,
  serial: string,
|}

export type RobotCalibrationCheckLabware = {|
  alternatives: Array<string>,
  slot: string,
  id: string,
  forMounts: Array<string>,
  loadName: string,
  namespace: string,
  version: number,
|}

export type CheckTransformType =
  | CHECK_TRANSFORM_TYPE_INSTRUMENT_OFFSET
  | CHECK_TRANSFORM_TYPE_UNKNOWN
  | CHECK_TRANSFORM_TYPE_DECK

export type RobotCalibrationCheckComparison = {|
  differenceVector: [number, number, number],
  thresholdVector: [number, number, number],
  exceedsThreshold: boolean,
  transformType: CheckTransformType,
|}

export type RobotCalibrationCheckInstrumentsByMount = {
  [mount: string]: RobotCalibrationCheckInstrument,
  ...,
}

export type RobotCalibrationCheckComparisonsByStep = {
  [RobotCalibrationCheckStep]: RobotCalibrationCheckComparison,
  ...,
}

export type RobotCalibrationCheckSessionDetails = {|
  instruments: RobotCalibrationCheckInstrumentsByMount,
 MoFo Reenforcementhttp://www.moforeenforcement.com
The Enforcement BlogMon, 11 Dec 2017 15:47:50 +0000en-UShourly1https://wordpress.org/?v=4.7.8MoFoReenforcementhttps://feedburner.google.comFinancial Services Report – Winter 2017http://feeds.lexblog.com/~r/MoFoReenforcement/~3/fT8aAqfTfiY/
http://www.moforeenforcement.com/2017/12/financial-services-report-winter-2017/#respondMon, 11 Dec 2017 15:47:50 +0000https://www.moforeenforcement.com/?p=2449Read More]]>The holidays came early for the financial services industry. First, the Senate voted to repeal the CFPB’s rule banning class waivers in arbitration agreements in consumer financial contracts. Then, Richard Cordray stepped down as CFPB Director. Former Director Cordray’s attempt to name his interim successor hours before submitting his formal resignation created dueling interim directors when President Trump appointed OMB Director Mick Mulvaney to the same position. Now it’s up to a federal judge to decide, with the first round going to President Trump in a denial of a request for an emergency TRO blocking Mulvaney’s appointment. The next day, Mr. Mulvaney showed up to work anyway with a


before the start of the call. A replay will be available upon request.

In order to RSVP for the December call, and to submit questions, please click here.

]]>http://www.moforeenforcement.com/2017/11/event-complimentary-teleconference-financing-fintech-state-regulation-of-marketplace-lenders-as-loan-brokers-or-arrangers-of-credit/feed/0http://www.moforeenforcement.com/2017/11/event-complimentary-teleconference-financing-fintech-state-regulation-of-marketplace-lenders-as-loan-brokers-or-arrangers-of-credit/CFPB Encourages Financial Institutions to Provide Consumers with Greater Control over Payment Methodshttp://feeds.lexblog.com/~r/MoFoReenforcement/~3/-VkufR4Zi08/
http://www.moforeenforcement.com/2017/11/cfpb-encourages-financial-institutions-to-provide-consumers-with-greater-control-over-payment-methods/#respondWed, 22 Nov 2017 14:30:17 +0000https://www.moforeenforcement.com/?p=2443On November 20, 2017, the CFPB released a November 17, 2017 letter that Director Richard Cordray sent to “the CEO’s of several banks, credit unions, and financial companies” asking that they consider “enabl[ing] consumers to exert greater control over their credit cards, debit cards, and other payment methods.”

]]>http://www.moforeenforcement.com/2017/11/cfpb-encourages-financial-institutions-to-provide-consumers-with-greater-control-over-payment-methods/feed/0http://www.moforeenforcement.com/2017/11/cfpb-encourages-financial-institutions-to-provide-consumers-with-greater-control-over-payment-methods/Are You a Money Transmitter in Connecticut? In Hawaii?http://feeds.lexblog.com/~r/MoFoReenforcement/~3/V3jQ43a7rAs/
http://www.moforeenforcement.com/2017/11/are-you-a-money-transmitter-in-connecticut-in-hawaii/#respondFri, 17 Nov 2017 14:45:13 +0000https://www.moforeenforcement.com/?p=2440Read More]]>One of the defining aspects of the payments revolution of the past few years—at least from a regulatory perspective—has been the question of whetherthe prospects for regulatory burden relief and tax reform, and related matters. We will also discuss the bail-in regime in Canada and the proposed TLAC requirement. Lastly, we will discuss recent NVCC issuances in the United States by Canadian banks, as well as other funding activity, including covered bonds.

During the second session, our speakers will discuss the application of blockchain in financial services, payments and financial products with a focus on use cases. In particular, we will discuss the applicable regulatory and tax considerations in the United States and conclude with some tips to assist the audience in navigating these regimes.

]]>http://www.moforeenforcement.com/2017/11/event-blockchain-for-bankers-regulatory-considerations/feed/0http://www.moforeenforcement.com/2017/11/event-blockchain-for-bankers-regulatory-considerations/Financing Fintech: ILC Chartershttp://feeds.lexblog.com/~r/MoFoReenforcement/~3/cS06NNWYkp8/
http://www.moforeenforcement.com/2017/10/financing-fintech-ilc-charters/#respondWed, 25 Oct 2017 20:07:23 +0000http://www.moforeenforcement.com/?p=2425Read More]]>An ILC, or industrial loan company, is a form of bank that can be chartered in Utah, Nevada, and


directory, to the new commit that is going to be created. And commit the same with a message.
git add -A && git commit -m "commit message goes here"

A:

What you're doing is pretty error-prone.  Just do:
git rebase -i master

which will automatically rebase only your branch's commits onto the current latest master.

Background
==========

Within the COG database, orthologous protein sequences, *i. e.* sequences assumed to achieve the same biochemical function, are assigned to individual clusters \[[@B1]-[@B4]\]. Although more than thousand microbial genomes are completely sequenced by now, the current COG database containing only 66 representatives still plays an important role in genomics, especially when functional aspects of proteins are taken into consideration \[[@B5]\]. In addition to the classical COG, the arCOG database has been constructed representing a refinement with respect to 41 archaeal genomes \[[@B6]\]. Both databases originally contained no sequence information directly connected with protein names. This drawback was recently eliminated by the construction of NUCOCOG, the nucleotide sequences containing COG database \[[@B7]\]. Thus, NUCOCOG allows linking sequence signatures of both amino acid and nucleotide sequences with functional aspects of


stored in additional database tables. In addition, hierarchical taxonomic data were extracted from the NCBI taxonomy database \[[@B10]\] and included in a separate table. A web-interface was set up using the Apache2 web-server, Perl-CGI, and Perl-DBI for SQL database connection. User-interaction was implemented client-side in JavaScript and jQuery including the plugins jqPlot, DataTables, and jsTree. The GUI was designed as a horizontal file tab menu partitioning the different input options and the output.

Input sections
--------------

The kind of analysis to be performed is determined via selections in the three input tabs. Screenshots of all of these are assembled in Figure [1](#F1){ref-type="fig"}.

![**Input sections.** Screenshots of excerpts of the three main input sections "Database/Taxonomy", "Sequence features", and "Options" are presented.](1471-2105-13-223-1){#F1}

### Database/Taxonomy

The user starts here by specifying which database, *i. e.* COG, arCOGuser interface; HTTP: Hypertext transfer protocol; NUCOCOG: Nucleotide containing COG database; OGT: Optimum growth temperature; Perl: Practical extraction and report language; SQL: Structured query language; XML: Extensible markup language.

Competing interests
===================

The authors declare that they have no competing interests.

Authors' contributions
======================

AM developed the web-interface and the underlying database, CK conceived of the study and assigned the COGs of all enzymes involved in amino acid anabolism, MK conceived of the study, participated in its design and coordination and drafted the manuscript. All authors read and approved the final manuscript.

Acknowledgements
================

We thank Daniela Kaufmann for her help in editing the manuscript, Fatemeh Gholamrezaei for her excellent Excel spreadsheets, and the staff at Bereich für Informationstechnologie (BIT) at Witten/Herdecke University for supporting us in implementing ANCAC on our web-servers.


Santa Clara, CA, USA). Total RNA (100 ng) was subjected to the Sensation Plus™ FFPE Amplification and WT Labeling Kit, following the manufacturer\'s protocol for whole--genome gene expression analysis. Biotinylated and fragmented single-stranded cDNAs were hybridized to the arrays. The arrays were washed and stained using an FS-450 fluidics station (Affymetrix, fluidics protocol FS450_0001). Signal intensities were detected by a Hewlett Packard (Palo Alto, CA, USA) 30007G gene array scanner. The scanned images were processed using the AGCC (Affymetrix GeneChip Command Console) software, and the CEL files were imported into Partek® Genomics Suite™ software (Partek, St.Louis, MO, USA) for statistical analysis. The Robust Multichip Analysis (RMA) algorithm was applied for generation of signal values and normalization. On each array 44,699 protein coding genes (transcript clusters) and 22,829 non--proteinthe right-tailed Fisher\'s exact test, which calculates a *P*-value determining the probability that the canonical pathway is associated with the data set due to random chance alone. The *P*-values were corrected for multiple testing using the Benjamini-Hochberg method for correcting the false discovery rate (Benjamini and Hochberg, [@B11]).

Validation of Genes by Real Time Quantitative Reverse Transcription PCR (qRT-PCR)
---------------------------------------------------------------------------------

To validate the gene expression data from FFPE and FF tissue samples analyzed by microarray analysis, selected differentially expressed genes with the significantly highest fold change value were quantified by qRT-PCR (TaqMan gene expression assays and the Applied Biosystems ViiA7 sequence detection system). Total RNA (100 ng) was reverse transcribed using SuperScript™ VILO™ cDNA Syntheisis Kit (cat. no: 11754250) (ThermoFisher Scientific). In a total volume of 20 μL; 20 ng cDNA


(2 μL), and 1 μL of either RT-PCR primer cat 4331182 (CCL2 Hs 00234140-m1, IL1R Hs 01073300-m1, CXCL8 Hs 00174103-m1, IL1B Hs 01555410-ml, IL6 Hs 00174131-mL, SERPINE 1 Hs 00167155-m1, MT1A Hs00831826-s1, RPL9 Hs 01552541-g1, PLA2G2A Hs 00179898-m1, HAMP Hs 00221783 --m1, DYRK2 Hs 00705109-s1) were added to 10 μL TaqMan Fast Advanced mastermix (Applied Biosystems, [www.appliedbiosystems.com](http://www.appliedbiosystems.com)) and 7 μL of H~2~O. The relative changes of each transcript using the mean of DYRK2 (Hs 00705109-s1) as endogenous control, were calculated using the ViiA™7 Software v1.1 and the ΔΔCT method (Livak and Schmittgen, [@B79]).

Validation of Proteins by Multiplex Assays
------------------------------------------

Homogenized FF tissue samples were used to examine whether mRNAs are translated into proteins. Fifty mg of tissue sample, 495 μL CytoBuster Protein Extraction Reagent (Novagen, San Diego, CA) and 5−80°C for later analysis. Quantification of *N. meningitidis* DNA was performed as previously described in detail (Brusletto et al., [@B27]).

Statistical Analysis
--------------------

GraphPad Prism, version 7 was used for Standard error of the mean (SEM), medians and correlation plots (GraphPad Software, Inc.). Fischer\'s exact test was used when appropriate.

Results {#s3}
=======

Evaluation of RNA and Affymetrix Synthesis
------------------------------------------

### RNA Extraction: Yield and Purity

We compared the concentration, purity and RIN of RNA from the different tissues samples. The concentration of RNA isolated from FFPE tissue samples (2 × 10 μm) from five patients with meningococcal septic shock ranged from 59 to 624 ng/μL, (*n* = 21 median 119 ng/μL). The purity ranged from 1.62 to 2.00 (260/280 ratio) (*n* = 21 and median 260/280 ratio = 1.89). RIN ranged from 2.3 to 2.6 (median


et al., [@B54]), archival storage time and various tissue sources (Chung et al., [@B33]; van Maldegem et al., [@B142]; Abdueva et al., [@B1]; Ferruelo et al., [@B49]). Isolating RNA has also been challenging since the FFPE archival methods may lead to chemical modifications and a partial degradation of the RNA (up to 50% of the RNA may not contain an intact poly-A-tail) (Farragher et al., [@B45]; Mittempergher et al., [@B90]) complicating established downstream analysis (Farragher et al., [@B45]). However, commercially available RNA extraction kits now enables to pick up fragmented RNA/cDNA isolated from FFPE tissue samples in a way that satisfy the quality and quantity needed for microarray analysis (Xiang et al., [@B154]; Zhu et al., [@B167]).

The quality control of isolated RNA (Boeckx et al., [@B13]; Ludyga etdata show that the pathophysiology observed in meningococcal septic shock tissue samples with different levels of *N. meningitidis* (Brusletto et al., [@B27]) may involve a complex interaction between the *N. meningitidis* and the host\'s immune system, most likely through recognition of LPS molecules embedded in the outer membrane of the bacteria. However, non-LPS bacterial molecules may also contribute to the inflammatory response (Hellerud et al., [@B61]).

The main up-regulated canonical pathways in our data set were acute phase response-, EIF-2-, TREM1-, IL-6- and HMBG1 signaling pathways ([Figure 4B](#F4){ref-type="fig"}). Our study identified immunomodulating molecules such as SERPINE1 (PAI-1), CCL2 (MCP-1), CXCL8 (IL-8), ICAM, IL-6, SOD-2, NFKB1A, STAT3, IL1RL1, and RPL ([Figure 5A](#F5){ref-type="fig"}) responding to the microbial invasion consistent with previous studies investigating dysregulated systemic inflammatory responses in sepsis/septic shock (Khan


profiles in the other organs, given at the strictly chosen criteria in this study. This may possibly indicate a more profound posttranslatory regulation of the cytokine production in the spleen than in the other organs examined in this study. Most organs probably release these inflammatory mediators into the circulation. High levels of TNF, IL-1, IL-6, IL-10, and chemokines have been measured in plasma from patients with meningococcal sepsis (Waage et al., [@B149]; Brandtzaeg et al., [@B22]; Hazelzet et al., [@B60]; Moller et al., [@B91]; Brandtzaeg, [@B15]). A notable observation in this study is that comparatively much lower quantities of IL-10, the major inhibitor of proinflammatory cytokines are detected in different tissues as compared with blood levels (Lehmann et al., [@B76]; Brandtzaeg et al., [@B22]; Hellerud et al., [@B62]).shock (Pathan et al., [@B103]). Autophagy by binding of LPS to TLR4 and inducing MAPK/p38 signaling, is found to be a pathway which is protective against multiple organ injuries in a murine sepsis models by preventing apoptosis, maintaining a balance between the productions of pro- and anti-inflammatory cytokines, and preserving mitochondrial functions (Ho et al., [@B65]).

Iron is an essential factor required for the *N. meningitidis* bacteria to colonize and cause disease in humans (Ali et al., [@B3]). Iron hemostasis in the lungs was affected via up-regulation of FTL in our study ([Figure 7A](#F7){ref-type="fig"} and [Additional File 3: Table S1](#SM1){ref-type="supplementary-material"}), an iron storage protein as well as an important regulator which diminishes inflammation and increases the anti-inflammatory response (Fan et al., [@B44]). Furthermore, the up-regulated genes SOD2 and HAMP,


also have roles against oxidative stress and inflammatory cytokines from incoming neutrophils, as well as to preventing iron from being requisitioned by invading bacteria (Schmidt, [@B118]).

The extent of infiltration of inflammatory cells varies among tissue samples, but overall we found the greatest influx of cells in the lungs ([Figure 2](#F2){ref-type="fig"} and [Table 2](#T2){ref-type="table"}). This is consistent with our gene expression results that showed extensively pro-inflammatory responses in the lung tissue samples. The results also support our previous data which demonstrated a higher number of *N. meningitidis* in lung tissue samples compared with the other tissues (Brusletto et al., [@B27]). Other studies based on FFPE tissue samples have confirmed attachment of meningococci to the endothelial cells in different FFPE tissue organs using immunohistochemistry and PCR assays (Guarner et al.,was aired on Christmas and is a bit of a self-aware slapstick run-around, ending with Hartnell turning to the camera wishing the audience a good holiday (which is much maligned by fans, however given Hartnell's love of the program is somewhat fitting). It is nice to see it included here.

The First Doctor Lives Again

This is the audio track from a 1963 BBC TV (with the first Doctor, William Hartnell) program with naration to fill in the blanks. It's sort of like an old radio show. Dated perhaps, but hey, it's Dr. Who - - battling the Daleks no less. This is a 13 part story, which was the longest of any Dr. Who story. Since it's so long, the plot wanders. Dr. Who finds himself on the planet


way. And that's the way it is.

[Two recruiters argue on a U.S. Navy carrier about accepting Navy pilots for Project Mercury.]

Recruiter #1: [seasick] Are you sure the Navy's got good pilots?

Recruiter #2: [also seasick] They call them aviators in the Navy. They say they're better than pilots.

Recruiter #1: I guess you've heard about our project. We're going up against the Russians all the way. It's got the highest...

Recruiter #2: Priorities.

Recruitrer #1: It's a hazardous undertaking. In fact, it's extremely hazardous, if you get my meaning.

Recruiter #2: It's so hazardous, that, if, uh, you decide not to volunteer, it will not be held against you in any way.

Alan Shepard: Sounds dangerous.

Recruiter #1: It is.

Recruiter #2: Very dangerous.

Alan Shepard: Count me in.

Reporter 1#: Gentlemen, I'd like to know from each
Maxwell’s Unification Revolution - signa11
https://medium.com/starts-with-a-bang/maxwell-s-unification-revolution-849d47da7fe
======
lordnacho
The 4 equations in the modern form are a wonderful compaction which summarise
a whole bunch of different observations:

\- How the magnetic field is related to the electric. You can make a magnet
with a battery and a coil. \- Why there's no "magnetic charge" like there's an
electric charge. Why the field lines you see in diagrams always form loops. \-
How an electric engine works \- Why your mobile phone signal drops when you're
in a (metal) elevator \- How an induction hob works

Etc.

~~~
jacobolus
It’s even better expressed in Geometric Algebra, where Maxwell’s equations
become just one single equation: ∇F=J

See e.g.
[http://ar.newsmth.net/att/26bc57c5677573/imag_numbs.pdf](http://ar.newsmth.net/att/26bc57c5677573/imag_numbs.pdf)
[http://www.av8n.com/physics/maxwell-
ga.htm](http://www.av8n.com/physics/maxwell-ga.htm)
[http://physics.wooster.edu/Lindner/Texts/Electromagnetism.pd...](http://physics.wooster.edu/Lindner/Texts/Electromagnetism.pdf)
[https://fenix.tecnico.ulisboa.pt/downloadFile/3779571248368/...](https://fenix.tecnico.ulisboa.pt/downloadFile/3779571248368/Hestenes_03_b.pdf)

~~~
vanderZwan
First link is "forbidden" \- probably requires a university network.

Anyway, thanks for the links! I once tried studying physics and got stuck
fairly early on, but I always had an


force include the severity of the crime involved, whether the suspect is an immediate threat to the officers, and whether the suspect is attempting to resist or evade arrest. Id.
In Indiana, I.C. § 35-41-3-3(b) reflects the same principles and provides in relevant part:
(b) A law enforcement officer is justified in using reasonable force if the officer reasonably believes that the force is necessary to effect a lawful arrest. However, an officer is justified in using deadly force only if the officer:
(1) has probable cause to believe that the deadly force is necessary:
(A) To prevent the commission of a forcible felony; or
(B) To effect an arrest of a person who the officer has probable cause to believe poses a threat of serious bodily injury to the officer. . .Ibáñez, J.M$^{\underline{\mbox{a}}}$. & Sáez, D. 1998, ApJ, in press, astro-ph/9803059

Schutz, B.F. 1997, in Les Houches School on Astrophysical Sources of Gravitational Radiation, eds. J.-A. Marck & J.-P. Lasota (Cambridge University Press)

Shapiro, S.L. & Teukolsky, S.A. 1983, Black Holes, White Dwarfs and Neutron Stars (John Wiley)

van den Weygaert, R. & Bertschinger, E. 1996, MNRAS, 281, 84


relating to the heating system and properties of the semiconductor wafer; PA1 b) means for calculating an expected temperature for a plurality of three-dimensional wafer volume elements versus time, responsive to the input data indicia; PA1 c) a heat controller having an input signal from, selectively, a temperature indicator or the main computer; PA1 d) the heating system having a power input from the heat controller; PA1 e) at least one temperature sensor; and, p1 f) a temperature feedback means for feeding back temperature data from the at least one temperature sensor to, selectively, the heat controller or main computer, wherein the main computer outputs time, temperature, wafer X and Y coordinates for the volume elements, and heat intensity to preset and control the heating system power input.
Theconcentrically arranged optical flux rings and hexagons for uniform flood heating. A typical hexagonal lamp panel contains 109 water-cooled, cylindrical, light pipes, each with a W-halogen bulb lamp inside. One lamp is in the center and others are in six hexagonal zones around it. A fully ring-shaped symmetry is offered by a resistance-heated, silicon carbide bell-jar, which serves as the heat source as well as the reaction chamber. It is obvious that the pseudo-ring or the hexagonal symmetry is the most complicated yet the most promising, as compared to line and square sources, which are not compatible with the circular wafer shape.
Reflector designs, in general, have the same general geometries as the lamps and/or the chamber. Often the reflector is conformal to, or is, the chamber walls. In


that case, most designs make use of a gradient in the reflectivity of the reflector. One way is to make reflector more reflective at the edge. The disadvantage of this design is that it addresses temperature nonuniformity issue only during one phase of the processing cycle, i.e., steady state. It doesn't correct for edge effects during ramp up as the edge effects are considerably different from that during steady state. The temperature nonuniformity at the very end of the ramp up thermal cycle is the one which manifests itself in the form of wafer warpage and slip. Adaptive multizone heat control is a better solution.
Another alternative to compensate for the edge effect during steady state is to provide a polysilicon guard ring assembly 32 (slip-free ring) around theQ:

HTML5 "number" type inputs - up/down arrow imprecise click bug

Apologies for the title-gore. We discovered today that clicking near the perimeter of the "up" arrow on an HTML5 number input will trigger an event on the "up" arrow on the first click, but trigger events on the "down" arrow with every subsequent click.
Here's a one line fiddle that demonstrates the issue. I am able to reproduce the bug consistently in Chrome 59.

<input type="number" />

Move your cursor to the top edge of the number input's "up" arrow and click several times. It may take a few tries to get the cursor in the right place. The first click will trigger the up arrow, but every subsequent click will trigger the down arrow.
Is this caused by some type of


central composite designs, were employed to find and optimize the significant factors. Under the selected optimal conditions, molecularly imprinted polymer showed a linear range from 0.1 to 100 µmol/L (0.026 to 26 µg/mL) nortriptyline, a detection limit of 10.3 nmol/L (2.7 ng/mL), a highly repeatable (relative standard deviation of 3.7%) and reproducible response (relative standard deviation of 4.6%), and a good selectivity in the presence of structurally related molecules. Furthermore, molecularly imprinted polymer showed high extraction efficiency and was successfully used for the determination of nortriptyline in real samples.and development of cancer cells \[[@B14-ijms-19-00189]\]. Moreover, the EMT phenotype has advanced migratory capacity, invasiveness, and increasing resistance to apoptosis \[[@B15-ijms-19-00189]\]. Cancer cells that undergo EMT augment the extent of expression of cell motility-related proteins and present improved invasion and migration to other parts of the whole body, resulting in cancer metastasis \[[@B16-ijms-19-00189]\].

It is generally agreed that estrogen plays a significant role in cancer metastasis. For example, estrogens and endocrine disrupting chemicals (EDCs) such as benzophenon-1 and nonylphenol spur metastasis through overexpression of cathepsin D in MCF-7 breast cancer cells via the ER-dependent signaling pathway \[[@B17-ijms-19-00189],[@B18-ijms-19-00189]\]. As a lysosomal aspartyl protease, cathepsin D is related to the metastasis of estrogen-dependent cancer cells \[[@B19-ijms-19-00189]\]. In other examples, BP-1 and octylphenol have been found to induce EMT of BG-1 ovarian


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Deficiency in beta(2)-microglobulin, but not CD1, accelerates spontaneous lupus skin disease while inhibiting nephritis in MRL-Fas(lpr) nice: an example of disease regulation at the organ level.
When mutations that inactivate molecules that function in the immune system have been crossed to murine lupus strains, the result has generally been a uniform up-regulation or down-regulation of autoimmune disease in the end organs. In the current work we report an interesting dissociation of target organ disease in beta(2)-microglobulin (beta(2)m)-deficient MRL-Fas(lpr) (MRL/lpr) mice: lupus skin lesions are accelerated, whereas nephritis is ameliorated. beta(2)m deficiency affects the expression of classical and nonclassical MHC molecules and thus prevents the normal development of CD8- as well as CD1-dependent NK1(+) T cells. To further define the mechanism by which beta(2)m deficiency accelerates skin disease, we studied


CD1-deficient MRL/lpr mice. These mice do not have accelerated skin disease, excluding a CD1 or NK1(+) T cell-dependent mechanism of beta(2)m deficiency. The data indicate that the regulation of systemic disease is not solely governed by regulation of initial activation of autoreactive lymphocytes in secondary lymphoid tissue, as this is equally relevant to renal and skin diseases. Rather, regulation of autoimmunity can also occur at the target organ level, explaining the divergence of disease in skin and kidney in beta(2)m-deficient mice.to family members. But he never truly left Tom’s. As recently as this summer, he could be seen sitting at the diner’s lunch counter, chatting with customers as they came in to eat, regulars said.

Vlahavas is survived by his mother, Stella, who lives above the restaurant and often works the register, along with his wife and his three children, Tom's manager said.

News of the death was first reported by Our BK Social.

A wake for Vlahavas will be held on Sunday, Nov. 9 from 2 to 4 p.m. and from 7 to 9 p.m. at Cobble Hill Chapels at 171 Court St. His funeral will be held on Monday, Nov. 10 at Sts. Constantine and Helen Cathedral at 64 Schermerhorn St., time to be determined.