and all with breakpoints within *tal* gene regions. We therefore attempted local assembly of just the *tal* gene regions using a custom assembly pipeline that combines components of the [hgap]{.smallcaps} workflow with the Minimo ([@mgen000032-Treangen1]) assembler ([Fig. 1](#mgen000032-f01){ref-type="fig"}). Using this approach for either genome, we were able not only to assemble all *tal* genes, but to identify and correct errors and omissions in those genes in the respective reference genomes (see below).

Correction of a frameshift within *tal2b* of BLS256 {#s2-2}
---------------------------------------------------

*tal2b* is one of eight TAL effector genes in the *tal2* locus of BLS256, two of which are labelled as pseudogenes in the reference assembly: *tal2b* because of a 1 bp insertion causing a frameshift within the CRR, and *tal2h* because of large deletions in the 5′ and 3′ endsrepeat region of the five-repeat gene. Next, we aligned the raw PacBio reads to the *tal* gene sequences in the PXO99A reference genome and identified 30 reads \>10 kb containing a *tal* gene with approximately five repeats. When aligned to the PXO99A reference genome, all of these reads mapped unambiguously to the *tal* gene region within the 212 kb duplicated sequence, with a gap in the CRR of *tal7b* (or *tal8b*) consistent with the internal deletion ([Fig. 2](#mgen000032-f02){ref-type="fig"}). This coverage is similar to what we observed for the junction of the duplication itself (36 reads \>10 kb; see below). Finally, we carried out Southern blot analysis of the PXO99A DNA using a *tal* gene-specific probe and observed a band corresponding exactly to the five-repeat gene (File S3).

The deletion confirmed, we next


we developed for BLS256, an Xoc genome, could also be applied to Xoo genomes such as PXO99A. After removing the contig for the truncated copy of *tal7b* we captured during localized assembly, and the reads that produced it, we were able to generate an assembly for PXO99A that differs from the reference by 10 bases, all indels. Both the automated protocol and our method collapsed the 212 kb tandem duplication into a single copy.

A schematic of our overall assembly pipeline is given in [Fig. 1](#mgen000032-f01){ref-type="fig"}. We have made an automated workflow for the local assembly, called the '[pbx]{.smallcaps} toolkit', available on GitHub (<https://github.com/boglab/pbx>). The PacBio assemblies for BLS256 and PXO99A have been deposited in GenBank as updates to the original accession numbers [NC_017267](NC_017267) and [NC_010717](NC_010717).

Evolution of *tal* gene content*tal7b* or in *tal8b*. We carried out PCR on each sample using primers corresponding to unique sequences flanking both *tal7b* and *tal8b* ([Fig. 4](#mgen000032-f04){ref-type="fig"}). Every sample that shows the duplication yielded a large band corresponding to the full-length gene and a small one corresponding to the short allele. Purification and sequencing of the smaller band (from the PXO99A-s sample) revealed a perfect match to the PacBio contig and corresponding Sanger reads that show the deletion. Thus, the deletion also dates back at least to the original PXO99 accession.

PXO99-'13, PXO99A-B and each of the seven PXO99A-s single-colony samples that likewise showed no evidence of the duplication yielded only the larger band that corresponds to the full-length gene. These samples represent at least two, probably three and possibly more independent


Extensive bullae formation in acute iliofemoral venous thrombosis.
A 58-year-old man presented with an acutely painful swollen left leg which was cyanotic and crowded with cutaneous bullae. After confirmation with color duplex ultrasound, intravenous streptokinase therapy was commenced with a bolus of 250,000 i.u. followed by maintenance infusion of 100,000 i.u. hourly for 72 hours. Treatment was changed to heparin for 14 days and then oral warfarin for another 6 months. Effacement of bullae accompanied subsidence of swelling of the leg. This case highlights the potential contribution of fluid retention in acute deep venous thrombosis to extensive bullae formation. This has not been previously reported in the literature.of quantum statistical physics [@balian2007]. In such approach the main paradigm is that of a “small” system of interest interacting with a “large” environment, about which we do not have control. Given the values of some physical properties of the system, like its mean internal energy or temperature, statistical physics asserts that the best description of the system is given by the canonical ensemble. In this open quantum system paradigm [@caldeira; @zurek2006; @breuer2002], as we don’t have access to the environmental degrees of freedom, and we often assume thermal equilibrium and weak interaction, the full microscopic state presents no correlations between system and environment. However, there are situations where the split between accessible and not accessible degrees of freedom is not so obvious and correlations build up, leading for example


The integral in (\[eq:avestatetrace2\]) is then now easily calculated: $$\begin{aligned}
\mathcal{A}_{\tr_E}[\rho]&=\rho\otimes\dfrac{\mathds{1}}{d_E}\overbrace{{\int}d\mu_\psi\,\pr_{\tr_E}(\psi|\rho)}^{=1} \nonumber \\
&=\rho\otimes\dfrac{\mathds{1}}{d_E}
\label{eq:avestatetrace3}.\end{aligned}$$ Therefore, in the partial trace case, the average state is just the tensor product between the coarse-grained state $\rho$ and the identity in subspace ${\mathcal{H}}_E$.

Averaging assignment: blurred and saturated detector {#sec:apblurred}
----------------------------------------------------

Here we calculate the average state related to the blurred and saturated detector, as induced by the coarse-graining map $\Lambda_\text{BnS}:{\mathcal{L}}({\mathcal{H}}_4)\rightarrow{\mathcal{L}}({\mathcal{H}}_2)$. Following the same steps as in the above calculation, the average assignment for the present case is given by: $${\mathcal{A}}_{\Lambda_\text{BnS}}[\rho] = \int d\mu_{\psi} \pr_{\Lambda_\text{BnS}}(\psi|\rho)\psi;$$ where $d\mu_{\psi}$ is the uniform Haar measure in ${\mathcal{H}}_4$, and the conditional probability $\pr_{\Lambda_\text{BnS}}(\psi|\rho)$ is non-null only in $\Omega_{{\Lambda_\text{BnS}}}(\rho)=\{\ket{\psi}\in{\mathcal{H}}_4\,|\,{\Lambda_\text{BnS}}[{| \psi \rangle\! \langle \psi |}]=\rho\}$.

The coarse-graining constraints imply that $\pr_{\Lambda_\text{BnS}}(\psi|\rho)\propto \delta(\Lambda_\text{BnS}[{| \psi \rangle\! \langle \psi |}]-\rho)$. Here, however, the symmetry obeyed by thisto run every time the database is updated through the web page (this is done) and then automatically return the String of updated records directly to the android app. How could I go about this?

A:

I would implement Google's Firebase Cloud Messaging API. It is fast, well integrated into Android (and many other platforms), reliable, and you get a ton of free features out of the box. You can look here for a quick feature overview to see if it is right for you.


"Gone Away" also featuring Leon Bridges.

Clark was featured on Tom Morello's album The Atlas Underground, providing vocals and guitar on the song "Where It's At Ain't What It Is."

On January 10, 2019, Clark announced the March 1, 2019 release of his new This Land album via Warner Bros. On the same day he also released the title song from the album supported by a Savanah Leaf directed music video for the song. This Land was chosen as a 'Favorite Blues Album' by AllMusic.

Live appearances

Clark performed at the 50th Monterey Jazz Festival as part of the promotion for John Sayles' 2007 film, Honeydripper.
Clark performed at the 2010 Crossroads Guitar Festival alongside B.B. King, Eric Clapton, Buddy Guy, Steve Winwood, John Mayer, Sheryl Crow, Jeff Beck, and ZZ Top.on CBS during their commercials for the 59th Annual Grammy Awards.
 Clark appears playing the songs "If Trouble Was Money" and "Bright Lights" live in a club during a 2018 episode of Netflix series Marvel's Luke Cage.
 "Our Love" is featured in the 2018 Marvel Film Venom.

Awards and recognitions
Kirk Watson, the Mayor of Austin, proclaimed May 3, 2001 to be Gary Clark Jr. Day. Clark was seventeen years old at the time.About Musicians Off the Record | Communication Studies | Moody College of Communication | The University of Texas at Austin . Motr.communication.utexas.edu. Retrieved on 2017-04-12. Clark won the Austin Music Award for Best Blues and Electric Guitarist, on three different occasions.

Clark was Spin's breakout artist for the month of November 2011.Rolling Stone magazine ranked Clark's Bright Lights


and related derivatives, such as anti-thrombotic and vasodilatory ([@B11]), anti-bacterial ([@B12]), anti-mutagenic ([@B13]) and cancer chemoprevention as well as anti-tumour ([@B14]-[@B18]), seem to originate from the coumarin nucleus ([@B16], [@B19]).

The current study aimed to evaluate the *in-vitro* cytotoxic and apoptogenic potential of MeOH and CH~2~Cl~2~ extracts besides three previously reported coumarins from*A. armeniaca* on two human apoptosis-proficient HL-60 and apoptosis-resistant K562 cancer cells. Extraction and isolation of the compounds were accomplished using the previously described method for purification of coumarin-hemiterpene ether derivatives ([@B7]).

Experimental
============

*Reagents and chemicals*

AlamarBlue^®^ (resazurin) from Sigma (Saint Louis, MO, USA); (RPMI-1640) and FCS from Gibco; Bax (Cat number: 2772), β-actin (Cat number: 4970) and PARP (Cat number: 9542) antibodies, anti-rabbit IgG and HRP linked antibody from CellSignaling technology (Boston, USA); ECL Western blotting detection reagent frommatrix.invert(matrix);
        }
        // преобразование
        matrix.mapRect(rectPreview);

        // установка размеров surface из получившегося преобразования
        sv.getLayoutParams().height = (int) (rectPreview.bottom);
        sv.getLayoutParams().width = (int) (rectPreview.right);
    }

    void setCameraDisplayOrientation(int cameraId) {
        // определяем насколько повернут экран от нормального положения
        int rotation = getWindowManager().getDefaultDisplay().getRotation();
        int degrees = 0;
        switch (rotation) {


data;

g. lodge a complaint to the supervisory body.

10. If the processing of your data takes place on the basis of your consent, you have the right to withdraw your consent at any time without affecting the legality of the processing, which was made on the basis of consent before its withdrawal.

11. Providing data is voluntary, but necessary to achieve the objectives for which they are collected.

12. If we process your personal data on the basis of the justified interests of the Administrator (e.g. for marketing purposes), we will no longer process them for the purposes indicated, if you appeal against such processing. You have the right at any time, to submit a free appeal to the processing of your personal data, if: (1) the processing of your personalGaddafi son's lawyer detained in Libya

Tripoli, June 9, 2012

A lawyer for the International Criminal Court (ICC) has been detained in Libya after she was found to be carrying suspicious letters for Muammar Gaddafi's captured son Saif al-Islam, a Libyan lawyer said on Saturday.

The Australian lawyer, named as Melinda Taylor, was part of a four-member ICC delegation that had travelled to the small western mountain town of Zintan where Saif al-Islam has been detained since his capture in the desert in November.

"During a visit (to Saif al-Islam), the lawyer tried to deliver documents to him, letters that represent a danger to the security of Libya," said Ahmed al-Jehani, the Libyan lawyer in charge of the Saif al-Islam case on behalf of Libya, and who liaises between the government and


charging station. With the batteries topped off, the Electric C30 can sprint from 0 to 60 MPH in 11 seconds while the BEV’s top speed is up around 81 MPH. The electrified C30 has a range of 94 miles and has no gears which means that the motor’s power is delivered seamlessly, and because of the electric motors gobs of torque are available instantaneously.import React from 'react'
import { Checkbox, Segment } from 'semantic-ui-react'

const CheckboxExampleFitted = () => (
  <div>
    <Segment compact>
      <Checkbox />
    </Segment>
    <Segment compact>
      <Checkbox slider />
    </Segment>
    <Segment compact>
      <Checkbox toggle />
    </Segment>
  </div>
)

export default CheckboxExampleFitted


b'th term of 694, 1373, 2042, 2701, 3350?
-5*b**2 + 694*b + 5
What is the t'th term of -9964, -19927, -29886, -39841, -49792, -59739, -69682?
2*t**2 - 9969*t + 3
What is the a'th term of 3803, 3857, 3953, 4097, 4295, 4553?
a**3 + 15*a**2 + 2*a + 3785
What is the z'th term of 705, 1390, 2061, 2718, 3361, 3990, 4605?
-7*z**2 + 706*z + 6
What is the p'th term of -1846, -1790, -1734, -1678, -1622?
56*p - 1902
What is the d'th term of 282, 490, 608, 618, 502, 242, -180?
-3*d**3 - 27*d**2 + 310*d + 2
What is the j'th term of -1335189, -1335188, -1335187, -1335186, -1335185, -1335184?
j - 1335190
What is the u'th term of 1061, 1253, 1447, 1643?
u**2 + 189*u + 871
What is the m'th term of -1756, -1794, -1872, -2002, -2196?
-2*m**3 -8*m**2 - 1746
What is the v'th term of -12485, -24946, -37435, -49958, -62521, -75130, -87791, -100510?
-v**3 - 8*v**2 - 12430*v - 46
What is the s'th term of -1282, -1298, -1314, -1330?
-16*s - 1266
What is the x'th term of -5477, -5513, -5553, -5597, -5645, -5697?
-2*x**2 - 30*x - 5445
What is the y'th term of -1674, -13373, -45134, -106989, -208970, -361109?
-1672*y**3 + y**2 + 2*y - 5
What is the s'th term of -31, -270, -479, -652, -783, -866, -895, -864?
s**3 + 9*s**2 - 273*s + 232
What is the l'th term of -240, -99, 42, 183, 324?
141*l - 381
What is the w'th term of 10325, 20608, 30851, 41060, 51241?
w**3 - 26*w**2 + 10354*w - 4
What is the o'th term of 1000, 1024, 1060, 1114, 1192, 1300, 1444, 1630?
o**3 + 17*o +


blesses you.

Even the most learned researchers and therapists quarrel about much. Take their advice and mine carefully. Don’t just listen to your heart, but also think; don’t just think, listen to your heart. Heart and head working together increase the odds you will find useful advice amid all the promises and hopes pushed at you be others. As others have noted, take what seems useful, leave the rest.

Disclaimer two: Forgive my grammatical errors

If you need perfect posts, you will not find them here; I will understand if you don’t follow, like or share what like me. Not only am I dealing with an aging brain, but all of my life I have been plagued by dysgraphia–a learning disability, Some of my posts might be peppered with bad spelling,The following morning, each participant was asked to sign a statement summarizing their activities over the course of the test—and falsely accusing them of hitting the escape key.

Half of those who had been up all night signed the document, compared to only 18% of those who had gotten a full night's sleep.

Lead researcher Kimberly Fenn said in a statement that “this is the first direct evidence that sleep deprivation increases the likelihood that a person will falsely confess to wrongdoing that never occurred." She added, “It’s a crucial first step toward understanding the role of sleep deprivation in false confessions and, in turn, raises complex questions about the use of sleep deprivation in the interrogation of innocent and guilty suspects.”

Advertisement

The study should, indeed, be seen just as a


  “Courtesy notice is provided that the Lake County Superior Court of California
has jurisdiction in this matter, and my client contends is proper venue should this matter
not be resolved informally. Please feel free to contact me by phone at [number] if you
have any questions. A demand letter may be forthcoming if a resolution isn’t reached.
       “Regards,
       “[signature]
       “Edward Starski, Esq.”
       Mayfield commenced an internal investigation that led him to conclude no such
“incident” occurred on the date and place specified in the letter. Additional investigation
found “no evidence that Mr. Starski was an attorney.” An employee did recall seeing
Starski in Cornett’s truck on the dayyears ago. Thus, Judge Behnke had no duty to amplify or
clarify the nontechnical term “unauthorized practice of law” without a request by Starski,
which he did not make. (People v. Griffin, supra, 33 Cal.4th 1015, 1022–1023.)
       As for Starski’s argument that “simply letting someone else believe one is licensed
to ‘practice law’ is insufficient absent some evidence of a fraudulent claim or
representation that one is authorized to perform services in a court of law,” it is refuted
by the same Supreme Court decision that explained “unauthorized practice of law.” And
sensibly so. Starski’s argument would exempt persons who never enter a courtroom or
act without a fraudulent purpose. (See Morgan v. State Bar, supra, 51 Cal.3d 598, 603
[“ ‘[t]he cases uniformly hold that the character of the


2563] (dis. opn. of Alito, J.)), Alvarez stated at a public meeting of his
local water board: “ ‘I’m a retired marine of 25 years. I retired in the year 2001. Back in
1987, I was awarded the Congressional Medal of Honor. I got wounded many times by
the same guy.’ ” Justice Kennedy, writing the plurality opinion, noted that “None of this
was true” and that “[l]ying was his [Alvarez’s] habit.” Alvarez’s statements “were but a
pathetic attempt to gain respect that eluded him. The statements do not seem to have
been made to secure employment or financial benefits or admission to privileges reserved
for those who had earned the Medal.” (Id. [132 S.Ct. at p. 2542] (plur. opn. of
Kennedy, J.).) The Stolen Valor Act (18 U.S.C.S. § 704) was struck down as an
overbroadand created Pleasant Valley Parkway, a landscaped boulevard similar in design to Blackstone Boulevard in the Blackstone neighborhood of Providence, though the residents attracted to the area were not as wealthy as their Blackstone counterparts.

In the early 1900s, Irish and Italian immigrants making their way out of crowded closer neighborhoods displaced the initial middle and upperclass residents.  Institutional growth came over the next few decades in the form of the founding of the Charles V. Chapin Hospital, the Providence Lying-In Hospital (now Women and Infants Hospital) – the first Women's Maternity Services facility in the region, and the Homeopathic Hospital of Rhode Island (now Roger Williams Medical Center).  Providence College and La Salle Academy moved to the area in 1917 and 1925 respectively.

Following World War II,


a human rights consultative committee as a standing body to assist the Human Rights Council.

Organisation
The Sub-Commission was first formed in 1947, under the auspices of the Economic and Social Council (ECOSOC).

Its primary mandate is described as:
 "To undertake studies, particularly in the light of the Universal Declaration of Human Rights, and to make recommendations to the Commission concerning the prevention of discrimination of any kind relating to human rights and fundamental freedoms and the protection of racial, national, religious and linguistic minorities".

Other functions and tasks could also be assigned to it by ECOSOC or the Commission on Human Rights.

It was composed of 26 human rights experts, each with an alternate and each elected for a term of four years, with half of the posts up for election everynext go from $n$ to $n+1$. Since $\theta$ is disjunctive, there is a $t_{n+1}>t_{n}$ such that $$\omega|{t_{n}}=\theta_{t_{n+1}}\theta_{t_{n+1}-1}\cdots\theta_{t_{n+1}-t_{n}+1}.$$ Now define $$\omega|{t_{n+1}}:=\overleftarrow{\theta|{t_{n+1}}}=\omega|{t_{n}}\overleftarrow{\theta|{t_{n+1}-t_{n}}}=\sigma|{s}\,\overleftarrow{\theta
|{t_{n+1}-s}}.$$ The second equality guarantees that the initial $t_{n}$ elements of $\omega$ are unchanged; the third equality follows from condition (2) of the induction hypothesis.

Concerning statement (3), assume that $\theta$ is strongly reversible, and let positive integers $M$ and $L$ be given. If $\omega$, as required, has the strong reversal property with respect to $\theta$, then there exists an integer $n\geq M+L$ so that $\theta_{n}\theta_{n-1}\cdots\theta_{1}
=\omega_{1}\omega_{2}\cdots\omega_{n}$, from which it follows that there is an integer $m \geq M$ such that $\theta_{m+L}\theta_{m+L-1}\cdots\theta
_{1}=\omega_{1}\omega_{2}\cdots\omega_{m+L}$ and therefore $\theta_{m+L}\theta_{m+L-1}\cdots\theta_{m+1}=$ $\omega_{1}\omega_{2}\cdots
\omega_{L}$. It follows that $\theta$ is reversible.

Concerning one direction of statement (4), assume that $\theta$ is reversible, and let $\omega$ have the required reversal property w.r.t.


f_{\theta_{k+1}}\circ f_{\omega}=(f^{-1})_{\theta|k+1}\circ
f_{\theta_{k+1}\omega},$$ the inclusion $$T_{\theta,k}\subset T_{\theta,k+1}$$ holds for all $k$. Therefore $$T_{\theta} :=\bigcup_{k=1}^{\infty}T_{\theta,k}$$ is a tiling.

![Graph IFS for the Penrose tiles.[]{data-label="Penrose"}](Penrose.png "fig:"){width="5in"} -3.5cm

(Penrose tilings of ${\mathbb{R}}^{2}$) In this example the graph $G$ is given in Figure \[Penrose\] where, using the complex representation of ${\mathbb{R}}^{2}$, the functions are $$f_{1}(z)=\left(  \frac{z}{\tau}+1\right)  \,\omega_{1},\qquad f_{2}(z)=\frac{-z}{\tau}+\tau^{2},\qquad f_{3}(z)=\frac{z}{\tau}\,\omega_{3}+\tau^{2},$$ where $\tau=(1+\sqrt{5})/2$ is the golden ratio and $\omega_{k}=\cos
(k\pi/5)+i\,\sin(k\pi/5),\,0\leq k\leq9$, are the tenth roots of unity. The acute isoceles triangle $A$ and obtuse isoceles triangle $B$ in the figure have long and short sides in the ratio $\tau:1$, and the angles are $\pi/5,2\pi/5,2\pi/5$ and $\pi/5,\pi/5,3\pi/5$, respectively. The attractor of the graph IFS is the pair $(A,B)$: $$\begin{aligned} A &= f_1(B)\cup f_2(A) \cup f_3(A), \\
B &= f_1(B) \cup f_2(A). \end{aligned}$$ Clearly, there are periodic tilings of thetriangles, and the other four functions map the square $S$ to the two smaller squares and two rectangles. One of the infinitely many possible tilings that can be constructed, using the method described of this section, is shown in the bottom panel.

![Another GIFS tiling; see Example \[ex:GIFS\].[]{data-label="fig:GIFS"}](graphIFStriangle.png "fig:"){width="2.5cm"} ![Another GIFS tiling; see Example \[ex:GIFS\].[]{data-label="fig:GIFS"}](graphIFSsquare.png "fig:"){width="2.5cm"}

Fractal Transformations from Tilings {#sec:FT}
====================================

The goal of this section is, given a fractal transformation, to extend its domain from the attractor of the IFS to the basin of the IFS, for example in the contractive IFS case, from the attractor to all of ${\mathbb{X}}$.

Fractal Transformation
----------------------

In Section \[sec:IFS\], each point of a point-fibred attractor an IFS was assigned a set of addresses. To choose a particular address for each point of the attractor, the following notion is introduced.

\[def:section\]


and self-affine tilings, *Constructive Approx.* **9** (1993), 327–346.

W. P. Thurston, Groups, tilings, and finite state automata, AMS Colloquium Lectures, Boulder, CO. (1989).

A. Vince, Replicating tessellations, *SIAM J. Discrete Math.* **6** (1993), 501–521.

A. Vince, Digit tiling of Euclidean space, *Directions in Mathematical Quasicrystals*, M. Baake, R. Moody, eds. (2000), 329-370.
Q:

PDFlib for php, is there an alternative

I looked at the PDFlib website and they seemed to be charging a hefty fee for use of the PDF libraries. Is there an alternative open source pdf extension to php???

A:

There are tons out there.
As some have mentioned, there are:

TCPDF
FPDF
Zend_Pdf
DOMPDF - CSS 2.1 compliant
WKHtmlToPdf
HTML2PDF

And there's a ton more out there if you look...
If you include commercial, I've heard good things about Prince...
Personally, I've had great luck with DomPDF...  TCPDF tended to be VERY buggy, but had a VERY active developer (which turned out to be a mixed blessing since the releases often broke the API), but then again this was years ago, so it could have changed. My experience with FPDF was that it was very buggy as well, with little


only the spatial connections between neurons but also the timescales of neural activity that act as important mechanisms leading to functional hierarchy in neural systems.

Functional hierarchy in neural systems, defined as the principle that complex entities may be segmented into simpler elements and that simple elements may be integrated into a complex entity, is a challenging area of study in neuroscience. Such a functional hierarchy may be thought of intuitively in two ways: as hierarchy in space, and as hierarchy in time. An example of hierarchy in space is visual information processing, where elemental information in narrow receptive fields is integrated into complex features of a visual image in a larger space. Hierarchy in time is exemplified by auditory information processing, where syllable-level information within a short timethat
“without giving guidance ... we had some serious
leverage on our fixed cost with the increased volume as you
look at the backlog, the backlog is going to settle more
towards the way it looked Q3 last year. So I
wouldn't expect the same level of leverage on fixed
cost.” [DE 53 at 27, ¶73.] Long went on to say
that this “depends on how the volume comes out in the
current quarter.” [DE 63 at 284.] It is the italicized
portion of this quote that is claimed to be actionable.

On
October 20, 2016, Supreme reported its third quarter 2016
results. Although higher net income and sales were reported,
Supreme also disclosed that the backlog was $58.1 million,
which was down from $74.4 million the previous quarter. [DE
53 at 28-29, ¶78.] Comparing third quarter 2016 backlog
to the previous year (third


choices. You can begin again. ❤

This morning I woke slowly, a second time, having returned to sleep upon waking much early during the wee hours. I woke feeling pretty good, and pretty balanced. I still do, which is nice; not everyone in my immediate vicinity is similarly fortunate. We are each having our own experience. Interestingly, so far this morning I am feeling content to enjoy mine without struggling in the face of experiences other people are not enjoying so much. It goes further, this morning; I have a certain flippant desire to say “That’s all you’ve got, Universe? You hit like a bitch.”

I experience the small emotional triumph alongside my immediate irritation with myself that I still use idioms that make light of the experiences of women,Sports 1 regularly and the radio networks with connections to the football-airing networks discuss spreads all the time. Also, longtime announcers such as Brent Musburger and Al Michaels have for years made veiled references to the line on a game.

Rece Davis settling in on College GameDay; inside Fox’s NFL coverage

“We talked about doing this all of the past off-season and we’ve considered this for a long period of time,” Lee Fitting, the coordinating producer for College GameDay, told this column earlier this month on the subject of gambling content. “We recognize that fans are very interested in this type of talk. Our goal on College GameDay is to serve the fans and we believe by doing this, from time to time and when we feel it’s right, serves


leader faces at the 72nd tee at The Players. I can't wait to hear the adjectives he uses to describe the pressure the players face on the final few holes as they try to win the FedExCup and the 10 million that comes with it. I'm so grateful to know that he's now with us for our Open Championship and Ryder Cup telecasts, events that carry extraordinary meaning to him, where his passion and his firsthand knowledge will help us take the coverage of these two incredible events to new heights. Finally, I'm so looking forward to hearing the repartee between David and Johnny Miller. It's going to be some pretty damned good television.”

When a high-profile talent makes a move to a competitor, there’s going to be plentywas so much to go over. Don Shula and the Dolphins were bedrocks of the NFL for 25 years. How many times did we see them on Monday night and dream of going to Joe's Stone Crab? Now the stadium struggles to sell out and half the fans are still wearing No. 13. They're still enormous in South Florida. You drive down Shula Expressway to Dan Marino Blvd to get to the stadium!”

5a. On Saturday NBC will televise its first heavyweight championship boxing match in primetime, WBC champ Deontay Wilder (34-0, 33 KO) vs. Johann Duhaupas (32-2, 20 KO), since May 20, 1985 when Larry Holmes beat Carl "The Truth" Williams on the network.

5b. Away from broadcasting, Baker has written a book on Jimi Hendrix and being influenced


the current Harvard Business Review.

• How far would you go to avenge the death of a sibling? The New Yorker’s Patrick Radden Keefe’s story about the obsessive, 3-decade quest of Ken Dornstein.API have anything to do with the RPC thread? (It makes RPC calls.)

A:

13 threads is pretty low.  Unfortunately, you won't be able to get rid of most of these threads without cutting functionality.
Getting rid of RPC & COM is most likely not possible for a managed app, and the CLR threads all seem to be doing something useful.  I'm guessing you're using GDI+ (probably via System.Drawing.)  Even though there are 0 worker threads running, the threadpool has the threads "on standby", ready to start.  You don't want posting a work item to have to incur the overhead of creating a new thread in an idle process.
Even though you may be using 40 MB of private memory, this is most likely not due to the


Electric Butterfly (arcwinolivirus) \[4K LN 'Luminous Wings' Arc\]](https://osu.ppy.sh/beatmapsets/581101#mania/1230133)
  - [Fallen Shepherd ft. RabbiTon Strings - ENDYMION (Gekido-) \[LN Master\]](https://osu.ppy.sh/beatmapsets/712276#mania/1505726)
  - [various - LN WALL PACK 2 (Skorer) \[Secret place \[Tier XI\]\]](https://osu.ppy.sh/beatmapsets/631167#mania/1332603)
  - [LeaF - Kyouki Ranmai (\_underjoy) \[Schizoid\]](https://osu.ppy.sh/beatmapsets/864118#mania/1807364)
  - [Aika - Sakura Trip (gemboyong) \[Well done\]](https://osu.ppy.sh/beatmapsets/726744#mania/1534444)
  - [Hiro - VERTeX (Raveille) \[Zenith\]](https://osu.ppy.sh/beatmapsets/853441#mania/1783681)
  - [Garigari Samushi - larva (Raveille) \[Magnesioferrite\]](https://osu.ppy.sh/beatmapsets/853443#mania/1783684)
  - [Camellia - Literal Crystal In The Cyphisonia (LovelySerenade) \[Il\[L\]umi\[N\]ize\]](https://osu.ppy.sh/beatmapsets/648293#mania/1373452)
  - [Various Artist - Jungdongjin's 10th 4k LN Pack (Jungdongjin) \[TeamGrimoire+amaneko - croiX (Marathon)\]](https://osu.ppy.sh/beatmapsets/640702#mania/1358798)
- Tiebreaker
  - **[BABYMETAL - Road of Resistance (eZmmR) \[Time of Revive\]](https://osu.ppy.sh/beatmapsets/791399#mania/1660337)**

### Semifinals

**[Download the mappack here! (163 MB)](https://mega.nz/#!6npVzSDI!HfsJwBHWnH_701dQofN328NEqmZWbaiLN2cP2mMT8I8)**

- FreeMod
  - [Sound Horizon - Raijin no Hidariude (-Kamikaze-, \_underjoy) \[Tempest w/ \_underjoy\]](https://osu.ppy.sh/beatmapsets/599091#mania/1266238)
  - [Keiichi Okabe -6 stars 5 Flowers (Skochan) \[4k LN Semi Final Stage 'The Last Petal'\]](https://osu.ppy.sh/beatmapsets/955385#mania/1995135)
  - [MDK - Press Start (juankristal) \[1up\]](https://osu.ppy.sh/beatmapsets/850118#mania/1777456)
  - [fripSide - Magicaride (Ver.2016) (Niima) \[EX\]](https://osu.ppy.sh/beatmapsets/528142#mania/1120269)
  - [gems - Gems Pack 16 - LN Master 7th (gemboyong) \[\[17\]ZUN - Green-Eyed Jealousy\]](https://osu.ppy.sh/beatmapsets/620521#mania/1307966)
  - [U1 overground - Dopamine (juankristal) \[Polyethylene Oxide\]](https://osu.ppy.sh/beatmapsets/695124#mania/1472944)
  - [LeaF - MEPHISTO (arcwinolivirus) \[4K LN Massacre\]](https://osu.ppy.sh/beatmapsets/535700#mania/1134593)
  - [Hatsuki Yura - The Clockwork Rose -Tokei Shikake no Bara Shoujo- (Gekido-) \[LN Master\]](https://osu.ppy.sh/beatmapsets/740979#mania/1563107)
  - [Whirligig231 - Battle Against A True Parent (scissorsf) \[Battle Against A True LN Master\]](https://osu.ppy.sh/beatmapsets/774898#mania/1628530)
  - [various - LN WALL PACK 1 (Skorer) \[Inner Universe [TIER X]\]](https://osu.ppy.sh/beatmapsets/616485#mania/1300157)
  - [Various Artist - Jungdongjin's 8th 4k LN Pack (Jungdongjin) \[DJ TAKA - ELPIS\]](https://osu.ppy.sh/beatmapsets/629866#mania/1329641)
  - [cosMo VS dj


\[Sprites\]](https://osu.ppy.sh/beatmapsets/836808#mania/1752295)
  - [Ester - Dizzolve (riunosk) \[Dizintegrate\]](https://osu.ppy.sh/beatmapsets/951988#mania/1987960)
  - [Two Steps From Hell - Strength Of Thousand Men (Skorer) \[Hero\]](https://osu.ppy.sh/beatmapsets/665780#mania/1409006)
  - [AZWZ - K/DA - POP/STARS (AZWZ x DIABOLOS REMIX) (Skochan) \[4k LN Quarter Final Stage 'Spark Down'\]](https://osu.ppy.sh/beatmapsets/951886#mania/1987774)
  - [ZUN - Voyage 1969 + 1970 (RemFangirl) \[Divine Life\]](https://osu.ppy.sh/beatmapsets/674877#mania/1427831)
  - [Amane - Dodger's Gadget (UNMIXED) (inteliser) \[Catastrophy [LN]\]](https://osu.ppy.sh/beatmapsets/727666#mania/1536202)
  - [kemu feat.GUMI - Life Reset Button (Kamikaze, Raveille) \[New Game Plus w/ Raveille\]](https://osu.ppy.sh/beatmapsets/850076#mania/1777378)
  - [Storyteller - Hatsune Miku no Gekishou (Raveille) \[With Wings I Can Fly\]](https://osu.ppy.sh/beatmapsets/830924#mania/1740846)
- Tiebreaker
  - **[gems - Gems Pack 14 - LN Master 6th (gemboyong) \[\[17\] Hanatan - Uta ni Katachi wa nai Keredo\]](https://osu.ppy.sh/beatmapsets/597080#mania/1265757)**

### Round of 16

**[Download the mappack here! (62 MB)](https://mega.nz/#!1sESAQgT!jHMEypnbBzITgtDMnH5SvPB_U2qG6g7rl8qzzuOaEZY)**

- FreeMod
  - [Mayumi Morinaga - dreamin' feat.of the trial judge under the title Dunbar & Sullivan Dredging Co. v. John R. Jurgensen Co., 44 F.R.D. 467 and for the reasons stated therein and in the order of dismissal of the cross claim we affirm the judgment of the District Court.

5
There is an additional reason why the judgment of the District Court should be affirmed. A careful reading of the so called cross claim shows that Jurgensen states no claim at all against McGovney. He seeks only to force McGovney to litigate his claim against Jurgensen in the within action in the District Court.

6
Affirmed.


is the half-cell potential measurement, the idea of which is illustrated in [Figure 1(a)](#fig1){ref-type="fig"}. The use of this method and the interpretation of its results are described in ASTM C876 \[[@B8]\]. Such corrosion potential measurements, however, should be supplemented with other nondestructive testing methods \[[@B9]--[@B12]\]. The use of half-cell potential measurements for determining the probability of corrosion in concrete was extensively described by Flis et al. \[[@B13]\], Grantham et al. \[[@B14]\], and Žvica \[[@B15]\]. The latter also presented dependences between the rate of reinforcement corrosion and temperature. The effectiveness of the test was studied in \[[@B16]\]. It should be noted that half-cell potential values merely provide information about the probability of corrosion and not about the rate of corrosion.

It is well known that the probability of corrosion inreturn reinterpret_cast<T(*)[N]>(&t);
}

template<typename T,std::size_t N>
BOOST_FORCEINLINE
const T (*addressof(const T (&t)[N]))[N]
{
   return reinterpret_cast<const T(*)[N]>(&t);
}
#endif

} // namespace mars_boost

#endif // BOOST_CORE_ADDRESSOF_HPP


(ty < 0)
		ty = 0;
	TCoord txR = tx + gbldcHq.ctx;
	TCoord tyB = ty + gbldcHq.cty;

	// this logic works because we won't actually occupy the spot in txR, just up to it.
	Size siz;
	gsim.GetLevel()->GetTileMap()->GetTCoordMapSize(&siz);
	if (txR > siz.cx) {
		txR = siz.cx;
		tx = txR - gbldcHq.ctx;
	}
	if (tyB > siz.cy) {
		tyB = siz.cy;
		ty = tyB - gbldcHq.cty;
	}
	if (ptp != NULL) {
		ptp->tx = tx;
		ptp->ty = ty;
	}
	bool fOccupied = false;
	TCoord txT = tx;
	FogMap *pfogm = gsim.GetLevel()->GetFogMap();
	for (; ty < tyB; ty++) {
		for (tx = txT; tx < txR; tx++) {
			Gob *pgob;
			if (!IsTileFree(tx, ty, kbfReserved | kbfStructure, &pgob)) {
				if (pgob != this) {
					fOccupied = true;
					break;
				}
			}
			if (pfogm->GetGalaxite(tx, ty) != 0) {
				fOccupied = true;
				break;
			}
		}
	}

	return !fOccupied;
}

void MobileHqGob::InitMenu(Form *pfrm)
{
	ButtonControl *pbtn = (ButtonControl *)pfrm->GetControlPtr(kidcTransform);
	LabelControl *plbl = (LabelControl *)pfrm->GetControlPtr(kidcCantTransform);
	bool fCanTransform = CanTransform();
	pbtn->Show(fCanTransform);
	plbl->Show(!fCanTransform);
}

void MobileHqGob::OnMenuItemSelected(int idc)
{
	switch (idc) {
	case kidcTransform:
		{
			// The player shouldn't have beenHe was not charged but the incidents highlighted the fact the two-year-old computer system was vulnerable to disclosures of both authorized and personal information collected by the province.

Click here to read “Province to abandon computer system at heart of Freedom of Information security failure.”

This article is for subscribers. Click here to subscribe.

2. Annie Leibovitz

“If money is what’s standing in the way of getting the pictures of famed portrait photographer Annie Leibovitz on the walls of the Art Gallery of Nova Scotia, it won’t be coming from the provincial government,” reports Michael Gorman for the CBC:

“As a government, no, we’re not prepared to negotiate a monetary settlement to get it exhibited,” Leo Glavine, minister of communities, culture and heritage, told reporters Thursday at Province House. More than 2,000 of


in the third quarter. Use also decreased with age, as 27% of 15- to 24-year-olds reported cannabis consumption, more than double the rate for people aged 25 and older (13%).

The Stats Canada release makes the claim that “the frequency of cannabis use has been associated with the risk of addiction, poor mental health, and reduced academic achievement,” which is undoubtedly true (Stats Canada won’t publish false stats), but that statement implies cause-and-effect rather than simple correlation, and if there is a cause-and-effect, it may be working in the opposite direction. That is, it’s possible that cannabis use doesn’t cause those social ills but rather that people addicted to other drugs or who have poor mental health or who aren’t doing well in school may use cannabis to relievemore than $250. For the first time, detailed data are available on cannabis users who spent in excess of $250 on cannabis. In the third quarter, about 14% of cannabis consumers (more than 650,000 Canadians) spent from $251 to $500 on cannabis, 7% spent from $501 to $1,000, and 3% spent more than $1,000 in the previous three months (or $333 per month, on average). People who reported consuming cannabis on a daily or almost daily basis typically reported higher expenditures—more than a quarter spent from $251 to $500 and another quarter spent more than $500. People who used cannabis infrequently were more likely to report little or no expenses. About two-thirds of cannabis users who consumed cannabis once or twice in the third quarter reported spending nothing


sexually alluring partner, humorous banter, lots of coffee, and dealing with problems about finding a place to pee from drinking so much coffee. But the reality is more prosaic.

At 8:30pm on September 11, Joseph set up surveillance of Timberleaf.

“I set up at an observation point at 1920 St. Margarets Bay Rd,” wrote Joseph. “There is a large sign on the front of the building showing ‘Timberleaf Alternative Healing Society. Open 7 days a week 9:00am to 10:00pm.’ I also noticed that there is tint on the doors but as the inside of the store is lit up and it was dark out you can see through the doors into the store. I observed several shelfs behind a counter. On the shelves there were glass jars, approximately 20 ofOur Projects

IDA CONTROL's automation robotics Expansion to Russia

After all these years of hard toil during which our Know-How in the Cutting Machines sector has reached a level of well-deserved maturity, IDA Control Automation Robotics understands that the next evolutionary steps to be taken are to establish cutting machine manufacturing units into the vigorously developing countries. These steps are the only way to increase the numbers of machines sold, given the fact that we consider the manufacturer’s physical presence in the relevant market equally important as (not to say more than) his formal presence; this is the only way to assure the prospective customer that he will receive the best post-sale support possible.

The market in which IDA Control aims to expand is the one of East European countries through


the gravity of their actions, and in asking Harvard to disassociate itself from this activity.

Over the weekend, my colleague Anthony Faiola had a fascinating dispatch from Vatican City about the modern pope’s very old-school warnings in a church that has increasingly de-emphasized the Prince of Darkness.

In this case, the church in Boston appears to be heeding his warning about a ritual that is considered at the very least the highest form of blasphemy, and at worst, a direct invitation to Satan.

AD

In general, “black masses” are intended to be a mockery of traditional Catholic Mass, though there is wide variation in how it is actually practiced. And there is also little historical evidence that it was commonly practiced at all.

AD

Despite this, the student club’s reasoning, according to its statement,is that the “historical event” is only being used as a tool to “explore religious facets that continue to influence contemporary culture.”

But aside from a few limited historical references, the “black mass” is mostly a fascination of modern so-called “satanists,” according to J. Gordon Melton, a professor of religious history at Baylor University.

AD

The first recorded black mass, Melton said, dates back to the court of Louis XIV of France. Seeking to use black magic to preserve his love for his mistress, Françoise Athénaïs, he enlisted the help of a renegade Catholic priest who drew upon lingering notions of pagan magic to perform the dark ceremony.

The secret sauce: a consecrated host or Eucharist (which Catholics believe is the body of Christ) and a murdered infant, Melton said.

AD

“They sacrificed a


shortstop, and four in right field. Eleven times, he’s switched positions mid-game, and he’s taken four different positions after entering as a pinch-hitter. Lately, he’s been working out at third base, and playing time there appears inevitable given the recent release of Asdrúbal Cabrera and the fact that he’s played the hot corner six times in his major league career.

If you can’t quite place Santana on the space-time continuum, you’re forgiven, as it’s been awhile since he was relevant. In May 2014, as the Twins were busily beating a path to their fourth straight season with at least 92 losses, they were receiving very little production from both shortstop Pedro Florimón and center fielder Aaron Hicks. In early May, they recalled the 23-year-old Santana, whom they’d signed outthen a quad strain; his bat failed to recover, too. Largely consigned to Triple-A oblivion, he only played 15 major league games last year, taking just 32 plate appearances for the Braves. For the 2015-18 period, Santana hit just .219/.256/.319 (49 wRC+) with -2.3 WAR in 735 PA. Among players with at least 500 PA across that span, only Omar Infante (47 wRC+), Alexi Amarista (48), and Jeff Mathis (49) were as bad or worse and only Victor Martinez (-3.5 WAR), Amarista (-2.7), and Mike Aviles (-2.4) returned less value.

The Rangers — who, again, lost 95 games last year and seemed capable of doing it again — signed Santana to a minor league contract in January and invited him to spring training, the kind of warm-body move that’s


typical for the genre. But this one turned out to be something besides garden variety. Santana, whose plus speed and versatility intrigued the team, caught the attention of new manager Chris Woodward. “When we met him in Spring Training, I didn’t know him at all,” Woodward told MLB.com’s Jessica Camerato in June. “[Bench coach Don Wakamatsu] was like, ‘I don’t know what it is. There’s something about him. He’s got a lot, a lot of talent.'”

The Rangers also noticed that Santana was relying upon his hands too much in his swing. Via the Fort Worth Star-Telegram’s Jeff Wilson:

“We saw some flaws that were preventing him from having success,” Woodward said. “His go-to when he struggled was, ‘Go with your hands.’ That’s not the correct sequencing of the swing.It actually is the worst thing you can do.” Santana has good hands, Woodward said, and the longer he can delay them and use his lower half to decide whether to swing or not, gives him better strike-zone recognition and keeps him from chasing bad pitches. He has been able to work himself into hitters’ counts and is taking advantage. Quieting the hands, which he referred to as “the dance,” has allowed his timing to improve. “I have worked a lot,” said Santana, who came to spring camp on a minor-league deal. “It has helped me a lot, and I want to stay like that the whole season. That’s the only change. I’m on time more. It’s more quiet. It’s a little more direct swing to the ball.”

Now,


of digital advertising, public relations and content marketing to create a community of brand advocates who interact, discuss and share the prospects of voting for BJP with millions of users across various social media platforms leading to a state of positive word of mouth.

There is a seamless integration in content strategy for different platforms right from Facebook to Twitter, YouTube, Google+, India 272+, Whats App and so on. The content posted is relevant and tailored as per the needs of the target audience. It is a classic case of being at the right place, at right time, with the right message to the right people. Each post has a logical connect and extension which propels the party’s proposition towards growth, development and good governance.

The content strategy for AAP_p0 *byte
	_p0, err = BytePtrFromString(oldpath)
	if err != nil {
		return
	}
	var _p1 *byte
	_p1, err = BytePtrFromString(newpath)
	if err != nil {
		return
	}
	_, _, e1 := Syscall6(SYS_LINKAT, uintptr(olddirfd), uintptr(unsafe.Pointer(_p0)), uintptr(newdirfd), uintptr(unsafe.Pointer(_p1)), uintptr(flags), 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func openat(dirfd int, path string, flags int, mode uint32) (fd int, err error) {
	var _p0 *byte
	_p0, err = BytePtrFromString(path)
	if err != nil {
		return
	}
	r0, _, e1 := Syscall6(SYS_OPENAT, uintptr(dirfd), uintptr(unsafe.Pointer(_p0)), uintptr(flags), uintptr(mode), 0, 0)
	fd = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func ppoll(fds *PollFd, nfds int, timeout *Timespec, sigmask *Sigset_t) (n int, err error) {
	r0, _, e1 := Syscall6(SYS_PPOLL, uintptr(unsafe.Pointer(fds)), uintptr(nfds), uintptr(unsafe.Pointer(timeout)), uintptr(unsafe.Pointer(sigmask)), 0, 0)
	n = int(r0)
	if e1 != 0


{
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Setdomainname(p []byte) (err error) {
	var _p0 unsafe.Pointer
	if len(p) > 0 {
		_p0 = unsafe.Pointer(&p[0])
	} else {
		_p0 = unsafe.Pointer(&_zero)
	}
	_, _, e1 := Syscall(SYS_SETDOMAINNAME, uintptr(_p0), uintptr(len(p)), 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Sethostname(p []byte) (err error) {
	var _p0 unsafe.Pointer
	if len(p) > 0 {
		_p0 = unsafe.Pointer(&p[0])
	} else {
		_p0 = unsafe.Pointer(&_zero)
	}
	_, _, e1 := Syscall(SYS_SETHOSTNAME, uintptr(_p0), uintptr(len(p)), 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Setpgid(pid int, pgid int) (err error) {
	_, _, e1 := RawSyscall(SYS_SETPGID, uintptr(pid), uintptr(pgid), 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THEint, err error) {
	r0, _, e1 := RawSyscall(SYS_INOTIFY_INIT, 0, 0, 0)
	fd = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Ioperm(from int, num int, on int) (err error) {
	_, _, e1 := Syscall(SYS_IOPERM, uintptr(from), uintptr(num), uintptr(on))
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Iopl(level int) (err error) {
	_, _, e1 := Syscall(SYS_IOPL, uintptr(level), 0, 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Lchown(path string, uid int, gid int) (err error) {
	var _p0 *byte
	_p0, err = BytePtrFromString(path)
	if err != nil {
		return
	}
	_, _, e1 := Syscall(SYS_LCHOWN, uintptr(unsafe.Pointer(_p0)), uintptr(uid), uintptr(gid))
	if e1 != 0 {
		err =


error) {
	var _p0 unsafe.Pointer
	if len(p) > 0 {
		_p0 = unsafe.Pointer(&p[0])
	} else {
		_p0 = unsafe.Pointer(&_zero)
	}
	r0, _, e1 := Syscall6(SYS_PREAD64, uintptr(fd), uintptr(_p0), uintptr(len(p)), uintptr(offset), 0, 0)
	n = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Pwrite(fd int, p []byte, offset int64) (n int, err error) {
	var _p0 unsafe.Pointer
	if len(p) > 0 {
		_p0 = unsafe.Pointer(&p[0])
	} else {
		_p0 = unsafe.Pointer(&_zero)
	}
	r0, _, e1 := Syscall6(SYS_PWRITE64, uintptr(fd), uintptr(_p0), uintptr(len(p)), uintptr(offset), 0, 0)
	n = int(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func Seek(fd int, offset int64, whence int) (off int64, err error) {
	r0, _, e1 := Syscall(SYS_LSEEK, uintptr(fd), uintptr(offset), uintptr(whence))
	off = int64(r0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE ISsetgroups(n int, list *_Gid_t) (err error) {
	_, _, e1 := RawSyscall(SYS_SETGROUPS, uintptr(n), uintptr(unsafe.Pointer(list)), 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func getsockopt(s int, level int, name int, val unsafe.Pointer, vallen *_Socklen) (err error) {
	_, _, e1 := Syscall6(SYS_GETSOCKOPT, uintptr(s), uintptr(level), uintptr(name), uintptr(val), uintptr(unsafe.Pointer(vallen)), 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func setsockopt(s int, level int, name int, val unsafe.Pointer, vallen uintptr) (err error) {
	_, _, e1 := Syscall6(SYS_SETSOCKOPT, uintptr(s), uintptr(level), uintptr(name), uintptr(val), uintptr(vallen), 0)
	if e1 != 0 {
		err = errnoErr(e1)
	}
	return
}

// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT

func socket(domain int, typ int, proto int) (fd int, err error) {
	r0,


the guidance document, pesticide companies can avoid conducting the dermal studies under these circumstances. Since 200 to 300 of these tests are carried out for pesticide formulations annually, more than 2,500 animals may be spared every year.

The new document is part of the EPA’s larger effort at significantly reducing the number of animals used to test pesticides, and the agency states that it will continue to work to minimize the number of animals used in toxicity testing.

While this latest action is a step in the right direction, PETA scientists will continue to work with the EPA and other governmental agencies to eliminate animal use in pesticide poisoning tests.

Updated March 16, 2016:

In yet another major milestone for animals, the Environmental Protection Agency (EPA) has announced its commitment to reducingof the surfaces provides a drive surface which is readily engagable for purposes of displacing, conveying, lifting, controlling and/or rotating the preform. For example, the drive surface can be either oval or multi-sided or the surface may have at least one recess or the surface may have alternating lugs and recesses. Thus, after the sidewall portion of the preform is blown into a blow molded article in the blow mold, a conveyance/drive mechanism is capable of engaging the drive surface and displacing the blow molded article within a trimming machine.
According to a further aspect of the present invention, an intermediate article formed during manufacture of a blow-molded plastic container is provided. The intermediate article includes an injection-molded neck portion defining an open top of the intermediate article and


the cells remain primitive, proliferate wildly, and wreak havoc.

About fifteen per cent of all A.M.L. patients carry the mutated enzyme. In recent months, Stein had been participating in a Phase 1 clinical trial of a drug, AG-221, designed to target it; the drug was developed by the pharmaceutical company Agios. Phase 1 studies represent the very first tests of a new drug in humans; they are mainly meant to assess a new drug’s safety, with little expectation that the treatment will help. Of the first ten patients who had been treated, three had died from their disease before the drug’s effects could be evaluated. But the data on six of the seven remaining patients were striking: five had gone into complete remission and one entered a partial remission.the sustained ACR20 response, which was similar during the first and second 24-week periods (36% and 42%, respectively). At week 48, ACR50 and ACR70 responses were demonstrated in 18% and 3% of patients, respectively, who continued taking anakinra (all dose groups) and in 20% and 1% of patients, respectively, who were originally receiving placebo and then were randomized to all doses of anakinra. Anakinra was well tolerated for 76 weeks. The only side effects that appeared to be treatment-related were skin reactions at the injection site. There was no evidence of decreased tolerance, an increased number of withdrawals, or an increased incidence of clinical complications associated with extended anakinra therapy. The clinical benefits of treatment with daily self-administered subcutaneous injections of anakinra in a cohort of patients with


is peaked for simultaneous photon arrival, Δ = 0. For photons with narrow Gaussian spectral function we find

In this limit the blockade is weak even in the absence of the time delay *τ* since the TLS re-emits photon over the time interval *γ*^−1^ which is much shorter than the time interval *σ*^−1^ over which each photons arrives. However, with Γ decreasing both the nonlinearity becomes weaker and a trivial single-photon off-resonant scattering plays a bigger role. Thus the full anti-bunching probability has a maximum at Γ \~ 1 as shown on the inset in [Fig. 4](#f4){ref-type="fig"}.

Methods
=======

The multi-photon scattering states for the model (1) can be described in terms of the Bethe ansatz eigenstates, see e.g. refs [@b13],[@b20], each state parameterised by a string of complex quasi-momenta. The physical implication of these complex-valuedquasi-momenta is the emergence of many-photon states weakly bound to the atom (TLS). The asymptotic scattering states constructed out of these eigenstates will be affected by such binding.

For the two-photon scattering states we will use a more straightforward and physically transparent approach based on the scattering matrix. Note that in two-photon (or multi-photon) scattering described by the model (1) two opposing tendencies compete: the statistical photon bunching clearly demonstrated by the dip in the coincidence counter in the idealised HOM geometry, and the nonlinearity caused by the fact that at any moment only a single photon can go through the TLS. It is this competition that spoils the ideal antibunching in the HOM geometry and the ideal resonant transmission (or reflection) in the geometries of [Fig. 2](#f2){ref-type="fig"}.

Scattering properties


of the atom-light interaction described by Hamiltonian (1) are encoded in the *S*-matrix, Eqs. [(2)-(3)](#eq11){ref-type="disp-formula"}, [](#eq14){ref-type="disp-formula"}, which links asymptotic incoming states to the corresponding outgoing states. Inevitable spontaneous emission means that in both the incoming and outgoing asymptotic state the TLS is in its ground state so that in specifying the asymptotic states one needs to refer explicitly only to their photonic part. To allow for time-resolved photons, in what follows we consider photons with a spectral function *g*(ω − ω~0~), centred around ω~0~ with a spectral width *σ*. For analytic calculations it can be chosen Gaussian,

but in general all we need to know is its centre, ω~0~, and width, *σ*. As we are considering on-shell scattering, ω = *q* (in the units where the group velocity of light is 1), weQ:

How to pass a larger buffer size to DCPCrypt 'UpdateStream' Procedure

I have a program that currently hashes files using just SHA1. No other options. It hashes them using the SHA1 hash function that's part of the Lazarus and Free Pascal Compiler.
I've since added the ability to use MD5, SHA256 and SHA512 by using the DCPCrypt library (http://wiki.lazarus.freepascal.org/DCPcrypt or http://www.cityinthesky.co.uk/opensource). Everything is working fine, however, my earlier version hashed the file in 2Mb buffers if the file was larger than 1Mb. If it was smaller than 1Mb, it used the default buffer of 1024 bytes, like this :
if SizeOfFile > 1048576 then  // if > 1Mb
    begin
     fileHashValue := SHA1Print(SHA1File(NameOfFileToHash, 2097152)); //2Mb buffer
    end
  else


 // HOW DO I ADD A BUFFER HERE?
          varSHA1Hash.Final(DigestSHA1);
          varSHA1Hash.Free;
          for i := 0 to 19 do                        // 40 character output
            GeneratedHash := GeneratedHash + IntToHex(DigestSHA1[i],2);
        end                   // End of SHA1 if

My question is how do I add aYet another problem from me (Also Idk if this is the right area for this)...

I've been using ACToolkit for a while now and have never had this problem before. I have 4 characters in my town. Caderyn, Storage1, Storage2, and Storage3. The last three are for obvious reasons. Now here's what's going on.

When I load the game, Caderyn's status hasn't changed. House is the same, plants, patterns, items, etc.
Storage1 has edited (Mario Paint stamp) patterns locked in from a few days ago. I changed them last night to roads, edited my town, and the patterns disappeared back to my originally edited MP stamp patterns. Along with this, the Mayor keeps coming over to congratulate me on the same thing every time.
Storage 2 is fresh after buying a house...every


the RS-27. The total thrust capability of the Atlas II of 490,000 pounds force (2,200 kN) enabled the booster to lift payloads of 6,100 pounds (2,767 kg) into geosynchronous transfer orbit (GTO) of 22,000 miles (35,000 km) or more. Atlas II was the last Atlas to use a three engine, "stage-and-a-half" design: two of its three engines were jettisoned during ascent, but its fuel tanks and other structural elements were retained. The two booster engines, RS-56-OBAs, were integrated into a single unit called the MA-5A and shared a common gas generator. They burned for 164 seconds before being jettisoned. The central sustainer engine, an RS-56-OSA, would burn for an additional 125 seconds. The Vernier engines on the first stage of the Atlas I were replaced by a hydrazine fueled roll controlpackage netlink

import (
	"fmt"
	"syscall"

	"github.com/vishvananda/netlink/nl"
)

func writeStateAlgo(a *XfrmStateAlgo) []byte {
	algo := nl.XfrmAlgo{
		AlgKeyLen: uint32(len(a.Key) * 8),
		AlgKey:    a.Key,
	}
	end := len(a.Name)
	if end > 64 {
		end = 64
	}
	copy(algo.AlgName[:end], a.Name)
	return algo.Serialize()
}

func writeStateAlgoAuth(a *XfrmStateAlgo) []byte {
	algo := nl.XfrmAlgoAuth{
		AlgKeyLen:   uint32(len(a.Key) * 8),
		AlgTruncLen: uint32(a.TruncateLen),
		AlgKey:      a.Key,
	}
	end := len(a.Name)
	if end > 64 {
		end = 64
	}
	copy(algo.AlgName[:end], a.Name)
	return algo.Serialize()
}

// XfrmStateAdd will add an xfrm state to the system.
// Equivalent to: `ip xfrm state add $state`
func XfrmStateAdd(state *XfrmState) error {
	// A state with spi 0 can't be deleted so don't allow it to be set
	if state.Spi == 0 {
		return fmt.Errorf("Spi must be set when adding xfrm state.")
	}
	req := nl.NewNetlinkRequest(nl.XFRM_MSG_NEWSA, syscall.NLM_F_CREATE|syscall.NLM_F_EXCL|syscall.NLM_F_ACK)

	msg := &nl.XfrmUsersaInfo{}
	msg.Family = uint16(nl.GetIPFamily(state.Dst))
	msg.Id.Daddr.FromIP(state.Dst)
	msg.Saddr.FromIP(state.Src)
	msg.Id.Proto = uint8(state.Proto)
	msg.Mode = uint8(state.Mode)
	msg.Id.Spi = nl.Swap32(uint32(state.Spi))
	msg.Reqid = uint32(state.Reqid)
	msg.ReplayWindow = uint8(state.ReplayWindow)
	msg.Lft.SoftByteLimit = nl.XFRM_INF
	msg.Lft.HardByteLimit = nl.XFRM_INF
	msg.Lft.SoftPacketLimit = nl.XFRM_INF
	msg.Lft.HardPacketLimit = nl.XFRM_INF
	req.AddData(msg)

	if state.Auth !=


reaction intermediates through supramolecular forces^[@CR30],[@CR31]^, the supramolecular systems that enforced cofactor, catalyst and substrate together would be beneficial to the effective biomimetic transformations^[@CR32],[@CR33]^. Moreover, this promising approach for coupling the artificial enzyme and the natural enzyme into one pocket of the enzyme would allow direct proton and electron transport between the two enzymatic processes through the proton and electron transport channels via NADH mimics (Fig. [1](#Fig1){ref-type="fig"}). The fine synergy of the reactions that occur inside and outside of the artificial host and the pocket of the natural enzymes would make the NADH-containing host--guest complex an attractive target for the development of supramolecular hosts for catalysis.Fig. 1Schematic of natural enzymatic system and catalyst--enzyme couple catalytic system.**a** Multienzyme cascade comprising flavin-dependent monooxygenase and formate dehydrogenase connected by diffusion of the nicotinamideshows the changes at 460 and 565 nm. **d** Partial ^1^H NMR spectra recorded during the reaction of an equimolar Zn**--ZPA** and RFT in the absence of oxygen under the irradiation at 455 nm in DMSO-*d*~6~.

In this case, irradiation of a CH~3~CN/EtOAc/H~2~O (8:1:1) solution containing Zn**--ZPA** (2.0 mM), RFT (4.0 mM) and **1a** (2.0 mM) with a typical 3 W household fluorescent lamp in the presence of oxygen for 12 h resulted in an 85% yield (Table [1](#Tab1){ref-type="table"}, entry 1, racemates, no further separation for the two enantiomers)^[@CR41]^. Notably, the reduced nicotinamide adenine nucleotide (NADH, 8.0 mM), the Hantzsch esters (HEHs, 8.0 mM)^[@CR42]^ or the ligand (H~2~**ZPA**, 8.0 mM), as alternatives to Zn**--ZPA**, could not efficiently insert an oxygen atom into the substrate **1a** (Table [1](#Tab1){ref-type="table"}, entries 2--4). Obviously, the confined space effect of compound Zn**--ZPA** plays the crucial role


a signal of flavin hydroperoxide that could also detected by potassium starch iodide test (Supplementary Fig. [29](#MOESM1){ref-type="media"})^[@CR45]^. The spectral results suggested that the short distance between the catalytic centers and cofactors due to the formation of host--guest species was the required for hydride transfer to form RFTH~2~, which could then react rapidly with oxygen to catalyze monooxygenation.

Isothermal titration calorimetry (ITC) experiments showed that upon the addition of RFT, Zn**--ZPA** gave enthalpic and entropic changes of Δ*H* = -- 0.58 kJ mol^−1^ and **--***T*Δ*S* = 26.81 kJ mol^−1^, respectively, and a Gibbs-free energy change of Δ*G* = -- 27.39 kJ mol^−1^ with an association constant of *K*~a~ = 6.23 × 10^4^ M^−1^ for the Zn**--ZPA** ⊃ RFT complex (Fig. [4b](#Fig4){ref-type="fig"} and Supplementary Fig. [24](#MOESM1){ref-type="media"})^[@CR46]^. The formation of the host--guest species was largely driven by entropic considerations, and this allowed the reproduction of the binding domain in the flavin-dependent enzyme^[@CR28]^ due tosynergistically with enzymatic catalysis and the HCOO^−^ oxidation reaction outside Zn**--ZPA** are simultaneous with mutual conversion between NADH models and NAD^+^ model on the capsule surface. Such an efficient catalytic result for the tandem process indicated that the rationally designed supramolecular catalytic systems were superior, as they eliminated the inherent communication barrier and interference between artificial catalysts and enzymes.

From a mechanistic viewpoint, this catalyst--enzyme coupled system based on the NADH-modified metal-organic capsule not only maintained the traditional advantages of confinement in supramolecular systems but also offered enhanced proton and electron transfer inside and outside the capsule through cofactor channels. The well-designed molecular squares, which have amide-enriched hydrogen-bonding sites, stacking interaction sites and hydrophobic pockets, could simultaneously encapsulate RFT and the substrate (Fig. [6](#Fig6){ref-type="fig"}). Inside the capsules, the well-matched shape


and interference between abiotic and biotic systems for effective catalysis based on NADH-modified capsules. The direct introduction of NADH mimics as transport channels for protons and electrons on the surface of a metal-organic host allowed the direct proton and electron transport between the two enzymatic processes inside the pocket of the enzymes without consuming cofactors. And it represents a distinguished example to integrate the cofactor, catalyst and reactant within a confined space for effective catalysis, which is an attempt for combining artificial and natural catalyst. The participation of different NADH-dependent oxidoreductases (for example, FDH and ADH) and substrates (for example, cyclobutanones and thioethers) in the combined artificial catalysis-enzymatic catalysis system with high efficiency and precise selectivity suggested the superiority of this supramolecular approach based on the electron andproton transmission channels of the capsules and the effect of spatial isolation, providing a host--guest catalytic platform for developing scalable and sustainable biocatalysis.

Methods {#Sec8}
=======

General methods and materials {#Sec9}
-----------------------------

Unless stated otherwise, all chemicals and solvents were of reagent grade quality obtained from commercial sources and used without further purification. ^1^H NMR was measured on a Bruker 400 M spectrometer with chemical shifts reported as ppm (in DMSO-*d*~6~ or CDCl~3~, TMS as internal standard). ESI mass spectra were performed on a HPLC-Q-Tof MS spectrometer using methanol as mobile phase. Isothermal Titration Calorimetry (ITC) was performed on a Nano ITC (TA Instruments Inc. Waters LLC). The elemental analyses of C, H and N were performed on a Vario EL III elemental analyzer. UV-Vis spectra were measured on a HP 8453 spectrometer. The


58.85; N, 17.13%. ESI-MS: *m*/*z*: 759.14 \[H~3~Zn~4~(**PMA**)~4~\]^3+^, 1138.17 \[H~2~Zn~4~(**PMA**)~4~\]^2+^.

General methods for the catalytic Baeyer--Villiger reactions {#Sec12}
------------------------------------------------------------

RFT (1.6 mM) combined with HCOONa (16.0 mM) or CH~3~CH~2~OH (3% in volume) was added to a CH~3~CN/PBS solution (2:1, pH 7.40, 5 mL) containing Zn--**ZPA** (1.6 mM) with a magnetic stir bar. A second stock solution of FDH (1 U mL^−1^) or ADH (60 U mL^−1^) in buffer solution was added to the above reaction vial, and then the substrate was added. The oxygen atmosphere in the reaction vial was maintained with an oxygen balloon, and a constant-temperature water circulation device maintained the reaction temperature at 37 °C. The vial was irradiated with a fluorescent lamp (3 W) with constant stirring for 9 h. At this point, another portion of enzyme (the same amount as before) was added, and the reaction was stirred      labels[ref] = "sub_%x" % ref
                code_xrefs.setdefault(ref, set()).add(addr)

            m = re.search(r'j\w{1,2}\s+(?:0x)?([\dA-Fa-f]+)\b', line)
            if m:
                ref = int16(m.group(1))
                labels[ref] = "loc_%x" % ref
                code_xrefs.setdefault(ref, set()).add(addr)

            for m in re.finditer(r',0x([\dA-Fa-f]{3,})\b', expr):


rev_symbol:
                    return ",\x1b[%dm%s\x1b[0m" % (color, labels[addr])
                else:
                    return m.group(0)
            return _f

        arrows = {}
        for k, v in [(True, u'\u25b2'), (False, u'\u25bc')]:
            arrows[k] = v.encode('utf-8')

        for line, addr, expr in lines:
 chunk2 = '\xe9\xfb\xff\xff\xff'
            return self.search(regexp_or(chunk1, chunk2), xonly=True)
        else:
            # search directly
            return ROP.gadget(self, keyword)

    def call(self, addr, *args):
        if isinstance(addr, str):
            addr = self.plt(addr)

        buf = self.p(addr)
        buf += self.p(self.gadget('pop', n=len(args)))
        buf += self.p(args)
        return buf


self.p(self.gadget('int80'))
        return buf

    def pivot(self, rsp):
        buf = self.p([self.gadget('pop', 'ebp'), rsp-self.wordsize])
        buf += self.p(self.gadget('leave'))
        return buf

    def retfill(self, size, buf=''):
        buflen = size - len(buf)
        assert buflen >= 0, "%d bytes over" % (-buflen,)
        s = self.fill(buflen % self.wordsize)
        s += self.p(self.gadget('ret')) * (buflen // self.wordsize)
        return s

    def list_gadgets(self):
           print

        print "%8s" % 'etc',
        for keyword in ['pushad', 'popad', 'leave', 'ret', 'int3', 'int80', 'call_gs10', 'syscall', 'loop']:
            try:
                self.gadget(keyword)
                print "\033[32m%s\033[m" % keyword,
            except ValueError:
                print "\033[31m%s\033[m" % keyword,
        print

class ROP_X86_64(ROP):
    regs


rsp):
        buf = self.p([self.gadget('pop', 'rbp'), rsp-self.wordsize])
        buf += self.p(self.gadget('leave'))
        return buf

    def retfill(self, size, buf=''):
        buflen = size - len(buf)
        assert buflen >= 0, "%d bytes over" % (-buflen,)
        s = self.fill(buflen % self.wordsize)
        s += self.p(self.gadget('ret')) * (buflen // self.wordsize)
        return s

    def list_gadgets(self):
        print "%8s" % 'pop',
        for i inrange(6):
            try:
                self.gadget('pop', n=i+1)
                print "\033[32m%d\033[m" % (i+1),
            except ValueError:
                print "\033[31m%d\033[m" % (i+1),
        print

        for keyword in ['pop', 'jmp', 'jmp_ptr', 'call', 'push', 'pivot']:
            print "%8s" % keyword,


random.choice(noppairs)
        return buf[:buflen] + code

    def exec_shell(self):
        return self.get('exec_shell')

    def exec_command(self, command):
        return self.get('exec_command') + chr(len(command)) + command

    def dup(self, code, fd):
        return self.get('dup', fd=chr(fd)) + code

    def readfile(self, path, fd=1):
        return self.get('readfile', fd=chr(fd)) + chr(len(path)) + path

    def readdir(self, path, fd=1):
        return self.get('readdir', fd=chr(fd)) + chr(len(path)) + path

    def read_stager(self):
        return self.get('read_stager')

    def mmap_stager(self):
   is running, attach the debugger if needed. Hit enter key to continue...\x1b[0m" % p.pid)
            e.set()
            p.wait()
            c.close()

        s = socket.socket(socket.AF_INET, socket.SOCK_STREAM)
        s.setsockopt(socket.SOL_SOCKET, socket.SO_REUSEADDR, 1)
        s.bind(('', 0))  # INADDR_ANY, INPORT_ANY
        s.listen(1)

        e = Event()
        t = Thread(target=run_server, args=(s, e, cmd))
        t.daemon = True


                  yield "%c%c%c" % (x, y, z)

    @classmethod
    def create(cls, size):
        s = ''
        for x in cls.generate():
            s += x
            if len(s) >= size:
                return s[:size]
        else:
            raise Exception("size too large")

    @classmethod
Center's production, which opened Thursday (Aug. 16) and will run through Sunday (Aug. 19), doesn't take itself seriously. The show is a pleasant, if not exactly memorable, diversion for a warm summer's evening. Read more

Reviewed by Nicholas Linnehan
I was very eager to see EPAC's summer Shakespeare production, The Tempest, at Endicott's George W. Johnson Park. It's my favorite Shakespearean work -- I love how it explores fantasy, spirituality and forgiveness -- so my expectations were high, and they were well met.
Director Tim Mollen offered a unique interpretation of this work, blending modern music without losing the classical style of the play. He simply brought together old and contemporary life, giving us the best of both worlds. There were several stunning moments...


husband, Little J is our 11 year old son, Juiciness is our 7 year old son, and his twin sister is Sassyfras- who has gone above and beyond to earn her nickname. I hope you will enjoy reading about our days.

If you wish to feature a post, please use only a picture or two with a link back to my original post. Please do not copy any post in its entirety.that you feel like it’s your car, but then a big Teamster grabs you and rips you out of there once the take is over,” says Connolly.

On set, the production designer is telling Ellin that the mansion they’re shooting at tomorrow is going to make the mansion they shot at last week look like a mud hut. Nearby, Jeremy Piven is looking bored. The actor took home three Emmy awards—and probably more than a few stomach ulcers—playing Ari Gold, the whirlwind of sarcasm, epithets, and frantic phone calls that powered most of the show’s drama like an indefatigable turbine. “It is exhausting, it’s extremely exhausting,” says Piven of playing the character. “Because your body thinks it’s real. Ari’s so perpetually revved up you go into fight-or-flight mode.”

When interviewing


= 6*q**2 - 2*q - 4. Let w be o(-3). Let l = 366 + -399. Let f = l + w. Is f composite?
False
Suppose -c - j + 10855 = -5792, -49953 = -3*c + 3*j. Is c a prime number?
True
Let p(j) be the third derivative of j**5/30 + 11*j**4/24 + 17*j**3/6 + 5*j**2. Is p(-6) prime?
True
Suppose h - 5*c = -4 + 2, 5*c - 10 = 0. Let u be 1*7/(28/h). Suppose 0 = -0*a - u*a + 442. Is a prime?
False
Let z(x) = -2*x**2 + 6*x - 4. Let b be z(4). Let m(w) = -11*w**2 - 53*w - 30*w - w**3 + 11 + 85*w. Is m(b) composite?
False
Is ((-11671)/(-3))/(40/120) prime?
False
Let x = -370 - -637. Let j be -1*(x - 4) + 2.t(c) = -116*c**2 + 8*c - 14. Let r(h) = -17*k(h) - 6*t(h). Let q be r(-4). Suppose -503 = -2*j + q. Is j a prime number?
True
Suppose 3*d + 0 = 5*s + 4, 3*d + 3*s = 12. Suppose -d*o + 841 = 4*j, -3*j + 636 = -2*o - o. Is j prime?
True
Let h(z) = 22*z**2 - 2*z - 18. Let v be h(8). Let c = v - 965. Is c prime?
True
Suppose 5*c - 2280 = -300. Suppose -c = -12*y + 8952. Is y prime?
False
Let h = -88 + 127. Is 9873/39 + (-6)/h composite?
True
Let l(q) = q**3 + 5*q**2 + 2*q. Let o be l(-4). Let y = 32 + -40. Is y/o + (214 - 2) prime?
True
Is 5 + (-111)/24 +


9557/8 prime?
False
Suppose 4*g - 23 = -111. Let b = -20 - g. Suppose 0 = u + b*u - 57. Is u a prime number?
True
Let z(i) be the first derivative of -i**4/4 - i**3/3 - 3*i - 8. Let g be -4 - ((0 - -3) + -2). Is z(g) composite?
False
Let v = -11612 - -30145. Is v composite?
True
Let y(p) be the first derivative of p**4/4 - 3*p**3 + 7*p**2/2 + 4*p + 2. Let k be y(6). Let q = k - -151. Is q a composite number?
False
Let b(h) = h**3 + 14*h**2 + 15*h + 16. Let o be b(-13). Let r = o - -1553. Is r a composite number?
False
Let m be (-4)/(-2) + 18/2. Suppose 11 = 2*v - m. Suppose v +a man in dark clothes bare of any official insignia, though they had that sharpness that marked a military uniform. I narrowed my eyes and studied him more closely because something about the picture didn't match: his body was soft. Not the softness of a soldier who had retired from action and moved to deskwork. This man was soft in both mind and body—he'd never served in battle.

_Paper-pusher. Gives orders for other men to die while sitting safe in home base._ "We were told you'd probably be down for another hour or more. I do apologize about the restraints—rather medieval, don't you agree? But we didn't think you'd be feeling particularly happy with us when you woke up, and killing you after all the trouble that we've gone


hearing. "Better? I am sorry. I didn't want to alert anyone."

Sorry for sneaking up on me or sorry for holding my mouth shut? I couldn't tell and didn't care. He was here, and I didn't feel so alone. Stefan was smart, dangerous, and _competent_. I hoped that I was the first two, but it was the third I really needed for this.

"Kyle's in trouble," I whispered back. Keeping our voices down made sense. People ignore the sounds of cars, but most of them will wake up to the sound of a strange voice. I didn't want to wake the neighborhood watch and try to explain to them what we were doing. "There is a car and an SUV parked by his house that shouldn't be there and nowas hurt and alone and I couldn't find him . . . but, silly me. Here he was, right beside me.

"Adam," I murmured.

The wolf stirred and put his nose on my shoulder. He was lying on top of me and making it hard to breathe under his weight. I vaguely knew it was a dream because Adam was both human and wolf at the same time, but Adam was more real than that thought, so I discarded it.

_You are alive,_ he said, and there was a relief in his voice that shook me.

"Of course I am."

_Something stirred the ant's nest,_ he said, nuzzling under my ear. _What did you do?_

I didn't want to think about it because then I knew I'd remember that this was just a dream,


had been watching too much TV, because a cot is no kind of protection at all—and then the woman pulled out one of the dart guns and started firing.

The first dart hit badly and bounced off his shoulder. Warned, he dodged the second two and jumped the cot to crush her skull between his jaws. He shook her once to break her neck and make sure of the kill, then dropped the body. He didn't enjoy killing women.

He stopped where he was, the corpse on the ground halfway between his front paws, and fought off the urge to eat her. Woman or not, his wolf was hungry, and dead, she was just meat. He didn't have time for it—and the strength of the urge meant the wolf wasI know you play gin rummy because Warren taught me to play it when I was a kid."

"Tell him," Adam said to Mercy.

"No games between two dominant wolves unless they know each other very well and have established their dominance. There was a very nasty chess match that happened in the Marrok's pack when I was six or seven. Bran put an end to it, but not before one of the wolves ended up with a pickax in his leg." Mercy continued instructing the uninitiated in her Mercy-matter-of-fact fashion. "Adam and Warren could play, for instance, because, though they are both dominant wolves, Adam has firmly established himself as more dominant in both their eyes. One lost game won't make any difference. Darryl and Warren, though, are second


"I rode in a car with a dead body."

Adam gave me a laughing glance. "I guess we might as well tell everyone the whole truth and nothing but the truth."

"It's a secret," Maia explained.

He ruffled her hair again. "Yes. But not a secret from your mom. You shouldn't keep those."

"I tell Mamá everything."

"Good for you."

"So," Jesse said, backing up a step, "I hear that you managed to survive without Mercy to rescue you this time."

He smiled. "Brat. Remember who's paying for your college."

She grinned at him. "Maybe I'll just get pregnant and work at fast food for the rest of my life." She turned and trotted off the way she had come before he could formulate a reply.

Amid laughter that had as much to do with relief weabout Adam. "I love you," he said.

"I know," I told him seriously. "How could you help it?"

He laughed again and rolled over until I was on the bottom, and flexed his hips against mine. "I tried," he whispered in my ear. "But it didn't work."

I breathed into his ear for the pleasure of feeling him shiver against me. "Of course not." He smelled like home, like safety, like love. "Of course not."

"I promise I won't spank you," he told me, his voice rough and low as he added, "not unless you ask me to."

I let him feel my laugh against his shoulder. "That's because you aren't genuinely suicidal."

We loved again then, the short nap of the rug soft under my skin and the warmth of him surrounding me.

Afterward,


and intronic regions of *[yellow](http://flybase.org/reports/FBgn0004034.html)* from *D. melanogaster*, *D. pseudoobscura*, and *D. willistoni*, which last shared a common ancestor 37 million yr ago ([@bib42]) ([Figure 1](#fig1){ref-type="fig"} and [Figure 2](#fig2){ref-type="fig"}). In *D. melanogaster*, the 5′ intergenic and intronic regions drive expression of *[yellow](http://flybase.org/reports/FBgn0004034.html)* in the developing body, wings, bristles, larval mouthparts, and denticle belts ([@bib19]; [@bib31]; [@bib57]; [@bib24]; [@bib25]). The 5′ intergenic region also harbors a *cis*-regulatory element required for proper male courtship behavior ([@bib16]). *[yellow](http://flybase.org/reports/FBgn0004034.html)* is also expressed in the embryo ([@bib51]) and larval brain ([@bib38]) of *D. melanogaster*, although specific *cis*-regulatory elements driving these expression patterns have not been identified. Prior work has shown that the 5′ intergenic and intronic regions from *D. pseudoobscura* and *D. willistoni* also contain *cis*-regulatory sequences that drive pupal expression when assayed insystem, and its absence leads to larval death at the third instar larval stage ([@bib3]; [@bib26]). *[CG8765](http://flybase.org/reports/FBgn0036900.html)*, Hormone-receptor-like in 38 (Hr38) (also known as *DHR38*), and *[intermediate neuroblasts defective](http://flybase.org/reports/FBgn0025776.html)* (*[ind](http://flybase.org/reports/FBgn0025776.html)*) were tied for the next most commonly binding TFs. They each showed evidence of interaction with two of the 26 fragments for at least two different 3AT levels. To the best of our knowledge, none of these three genes have previously been implicated in regulating *[yellow](http://flybase.org/reports/FBgn0004034.html)* expression, and thus represent new candidates for direct regulators of *[yellow](http://flybase.org/reports/FBgn0004034.html)*. The full list of TFs with the number of 3AT levels that showed a significant (p-value \< 0.005) interaction with each DNA fragment is shown in [Table S2](http://www.g3journal.org/lookup/suppl/doi:10.1534/g3.116.032607/-/DC1/TableS2.xlsx). These genes include *[Abd-B](http://flybase.org/reports/FBgn0000015.html)*, which was previously shown to directly bind to *D. melanogaster


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                        {columns.map((column, i) => (

                                {column.label}

   the combined results, indicating the reliability and stability of our results.

Discussion
==========

MTHFR plays an important role in the regulation of DNA synthesis, methylation, and repair. Thus, DNA methylation and synthesis may be affected by alterations in the enzyme activity of MTHFR, which subsequently increases the incidence of malignancies[@b18][@b34]. Previous studies have confirmed that these common functional polymorphisms of *MTHFR* give rise to a thermolabile enzyme with significantly reduced enzyme activity[@b19][@b20]. Numerous studies have been conducted to investigate the relationship between *MTHFR* C677T or A1298C polymorphisms and the cancers risk, and these polymorphisms were associated with a low risk of colorectal cancer[@b35], and an increased risk for non-Hodgkin lymphoma[@b36]. However, there are controversial findings about the role of *MTHFR* C677T and A1298C polymorphisms in the development of MM. González Ordóñez


stratification analyses by quality score of studies found that C677T polymorphism in *MTHFR* was significantly associated with an increased risk for MM under all four genetic models in studies with intermediate quality, but not in high-quality studies, which suggested that the methodological quality of the included studies might be a critical effect factor on the association.

However, this meta-analysis has some limitations which need to be addressed. Our analyses were based on unadjusted OR values without adjustment for other covariates such as age, gender, folate intake status, and exposures, which may result in relatively low power to estimate the real association. Some stratification analyses might have insufficient statistical power to detect the effect because of the limited number of included studies. Folate status may influence the association of *MTHFR*"plasma cell myeloma" or "myeloma" or "myelomatosis", without any restriction on the language. A manual search for references cited in the eligible articles was also performed to look for additional studies.

Inclusion criteria
------------------

Studies included in this meta-analysis had to meet the following criteria: (a) case-control studies about the association of *MTHFR* C677T or A1298C polymorphisms with MM risk; (b) the case group had confirmed diagnosis; (c) genotype frequencies for both cases and controls were available; (d) the distribution of genotypes in the control group was in consistent with Hardy-Weinberg equilibrium (HWE). If there were multiple articles from the same study, the most relevant was included. The case reports, letters, meta-analysis, and reviews were excluded.

Data extraction
---------------

The following information were extracted from each included study: first author's name, publication year, country,


of data: L.-M.M. and L.-H.R. Analysis and interpretation of the data: L.-M.M., L.-H.R. and H.-P.Y. Writing and revision of the manuscript: L.-M.M. and L.-H.R. All authors reviewed the manuscript.

![Flow diagram of study selection.](srep10735-f1){#f1}

![Meta-analysis for association of *MTHFR* A1298C polymorphism with MM risk (AC + CC vs. AA; stratified by ethnicity).](srep10735-f2){#f2}

![Meta-analysis for association of *MTHFR* C677T polymorphism with MM risk (TT vs. CC + CT; stratified by ethnicity).](srep10735-f3){#f3}

###### Main characteristics of studies included in the meta-analysis.

  **First author**          **Year**               **Country**               **Ethnicity**   **Control source**    **Genotyping method**    ***MTHFR*polymorphisms** On the face of it, Black Friday should be of great interest to frugal zealots. Living frugally has many facets, and one obvious one is the careful husbanding of resources, making sure that you spend no more than you have to. That way you can avoid debt, work less, pile up some savings as security, and even have something available for the occasional indulgence.

Here’s how Black Friday fits into this strategy. You need certain things, like a new fridge or a winter coat; but you don’t just rush out and buy them. You do your research, plan ahead, and wait for the maximum discount to appear before you strike. Black Friday is (supposedly) the day of the greatest possible discount. So you make a flask of hot chocolate,


an access line, which is commonly referred to in the art, and herein, as a “word line.” However, each memory cell may not be directly coupled by its drain to a data line, which is commonly referred to in the art, and herein, as a “bit line.” Instead, the memory cells of the array may be coupled together in series, source to drain, between a common source and a data line, where the memory cells commonly coupled to a particular data line are referred to as a “column.”
Memory cells in a NAND array architecture may be programmed to a desired state. For example, electric charge can be placed on or removed from a charge storage node, such as a floating gate, of a memory cell to put thediversity index, and phylogenic diversity at species level. We found that there was no difference between the groups ([Fig 2](#pone.0217194.g002){ref-type="fig"}). These data show that bacterial species diversity was unaffected by 6-OHDA lesion.

![The alteration of bacterial diversity between sham-operated and 6-OHDA-lesioned mice.\
These data are analyzed by (A) Shannon index, (B) Simpson index, and (C) phylogenic diversity index. Values are expressed as box and whisker which presents the median and quartiles of the data. n = 9/sham-operated group; n = 10/6-OHDA-lesioned group.](pone.0217194.g002){#pone.0217194.g002}

The alteration of relative abundance in 6-OHDA-lesioned mice {#sec010}
------------------------------------------------------------

To investigate whether 6-OHDA treatment could affect gut microbial environment, the proportion of each taxon at the family, genus, and species levels was compared between sham-operated and 6-OHDA-lesioned groups. The ratio was limited to each taxa containing 1% or more. At


mice exposure to repeated 6-OHDA or inoculation of germ-free mice with *B*. *acidifaciens* \[[@pone.0217194.ref052], [@pone.0217194.ref053]\]. It is reported that IgA plays a critical role in maintenance of gut microbiota composition and is presumed to prevent intestinal damages from external pathogen \[[@pone.0217194.ref054], [@pone.0217194.ref055]\]. *Lactobacillus* and *B*. *acidifaciens* are widely known as sensitive bacteria against alterations of gut environment induced by external insults. It has been reported that the abundance of *B*. *acidifaciens* which modulated host immunity was remarkably increased in large intestine of trinitrobenzenesulfonic acid-induced colitis and *Salmonella*-infected gastroenteritis, respectively \[[@pone.0217194.ref056], [@pone.0217194.ref057]\]. Thus, *Lactobacillus* and *B*. *acidifaciens* are expected to be more sensitive to external toxins like 6-OHDA than other bacteria.

In a recent microbiome analysis of the cecal sample in mice induced by intraperitoneal injection of 6-OHDA, peripheral 6-OHDAspooled-up to monitor the Soyuz-FG’s myriad systems throughout ascent. Inside the control bunker, the “launch key”—an actual, physical key—will be inserted in order to enable the ordnance to support Soyuz TMA-15M on its voyage. This will be followed by the completion of nitrogen purging, the pressurization of the rocket’s propellant tanks and the continued topping of cryogens.

A minute before liftoff the Soyuz-FG will transfer to internal power, and at T-10 seconds the engine turbopumps will attain full speed. By five seconds, the engines of the core and tapering boosters will roar to life and quickly reach full power. This will produce a retraction of the fueling tower and a liftoff into the darkened Baikonur sky at 3:01:13 a.m. local time Monday, 24 November (4:01:13 p.m. EST Sunday, 23


Wilmore, Samokutyayev, and Serova expected to remain aboard the station until March, and Shkaplerov, Virts, and Cristoforetti anticipated to return to Earth in May, the impending joint mission promises to be a busy one, with scientific research, a handful of visiting vehicles, and several EVAs planned. Speaking in September 2014, Virts remarked that some 240 experiments—about 170 provided by the United States, including academic and commercial payloads, and 70 others by international scientists—will be undertaken in the U.S. Orbital Segment (USOS), whilst Shkaplerov added that his role in the Russian Orbital Segment (ROS) would encompass medical and biological studies, in addition to around 50 other investigations already in work aboard the ISS. “It would take a long time to list all the experiments,” he told an audience atmonitor blood flow to his eyes. Bone loss experiments will also be performed, with Virts noting that regular exercise has helped crews—including the Expedition 40 team, who returned in September 2014, with a virtually insignificant 0.3 percent of bone tissue loss—to maintain their health and physical strength during lengthy missions.

Aside from the dedicated experiments, the crew has also trained extensively to handle unexpected medical contingencies, which Virts described as “a diverse job.” On his STS-130 shuttle flight, back in February 2010, the crew included a dedicated medical officer, but for ISS expeditions each member of the team has to assume the mantle of the scientist, the mechanic, the doctor, the sewage worker, the cook, and the cleaner. In readiness for their six months in space, Shkaplerov, Virts, and


my own experience would make me uncomfortable batting without gloves: the fear of a painful sting can commandeer a batter’s consciousness and distract him from focusing on hitting the ball. Batting gloves removes that fear, allows a batter to concentrate further and enables him to make more solid contact more often. Clearly, as their prevalence implies, batting gloves enhance performance, directly or indirectly.

Before we assess the acceptability of batting gloves, let’s consider other performance-enhancing tools. As a player, I was one of the first high school athletes to try Nike’s new contact lenses that are tinted so that they filter certain frequencies of light, theoretically enabling a player to see certain objects better. Nike describes them as “one-of-a-kind tinted soft contact lens that gives added visual improvements forI gained from using NO2 X-Plode helped me become a better wrestler (from awful to just about average) and helped me win more matches (…more than zero). Without question, all of these supplements enhanced my performance by a very significant margin (again, relatively speaking to my previous performance).

Beyond sports – Fluoride, extra time, prosthetic limbs

Carlos Ruiz wasn’t smiling after being suspended for 25 games in 2013 for testing positive for Adderall. (Credit: Eric Hartline, Delco Times)

This desire for improvement extends to ingested substances and medicine as well. The government puts fluoride in the water supply in order to improve dental hygiene. More recently, many students are prescribed Ritalin, Adderall and other drugs in order to improve attention. Furthermore, those students often are allowed “extra time” on standardized tests.


do all they can to enhance their performance. It is the American way and it is human nature. Performance enhancers – in and of themselves – are not the enemy.

Rather, dishonest attempts to confer on yourself an unfair advantage are (should be) the enemy. Throwing a spitball, having tar in your glove, corking your bat or sabotaging the opponent’s equipment are all “performance-enhancing” activities that are outlawed with good reason. They are not outlawed because of their performance enhancing ability, but rather because they represent malicious behavior with the specific intent of un-leveling the playing field.

From the inception of organized sport – really from the inception of animal “play” – humans have had an aversion to cheating and unfairness. Even three-year-olds understand this concept and get upset ifremove of all illegal West Bank settlements (March 2011) – Following a petition submitted by Peace Now to the Israeli Supreme Court, Benyamin Netanyahu's government ordered that the state dismantle all illegal West Bank outposts built on private Palestinian land by the end of 2011.

 Migron (ongoing)- Following a petition to the Israeli Supreme Court by Peace Now, the state was ordered to dismantle Migron, the largest illegal settlement outpost in the West Bank, by April 2012. This was key as this was the first time the Supreme Court had ordered the Israeli state to dismantle an outpost in the West Bank.

Similarly, the movement continues activity on the ground in support of evacuation through demonstrations, vigils and other campaign activity. Activities include:-

Updates on settlement expansion by means of


on such social networking sites as Facebook. Against the background of the 'Boycott Laws' which were being passed through the Knesset in July 2011, the popular Israeli internet site 'Horim B’reshet' made a survey of the most popular Israeli protest Facebook pages, of which Peace Now's page ranked 5th.

West Bank tours for opinion-makers
Peace Now aims to educate leading decision makers on the perceived counterproductive effects the settlements have on the attainment of the two-state solution.

One such tour was conducted by Peace Now in August 2009 and attended by such figures as
MKs Ophir Pines-Paz (Labor), Daniel Ben-Simon (Labor) and Chaim Oron (Meretz Chairman).

Demonstrations/rallies

Peace Now organises demonstrations and rallies in support of peace and human rights:-

Rally Against Racism (26 February 2011) – Peace Now joined 1,500 other activists at    if (count($this->htmlEditor) == 1) {
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