up-regulation of a number of DNA polymerases, including PolM, PolE2, PolD3, and PolS, suggesting that both replicative and repair DNA machinery was affected by HtrA1 down-regulation.

Finally, pathways important in cancer progression were affected by HtrA1 expression levels. For example, factors within the angiogenesis and HIF pathways, such as HIF1A, VHL, FGF family members, AKT1, and VEGFB/C genes, all showed major increases in the HtrA1 down-regulated MCF10A/siRNA cell lines and decreases in the MCF10A/HtrA1 over-expressing cell line ([Table 1](#pone-0039446-t001){ref-type="table"}). Each of the MCM2-7 genes showed coordinated down-regulation, which is of interest because these MCM proteins are negative regulators of HIF1 [@pone.0039446-Hubbi1] and exposure to hypoxia leads to their down-regulation. We also observed that AKT was phosphorylated (at Ser473) in the MCF10A/siRNA cell lines using immunoblot analysis (not shown); thisInterestingly, we have also made a number of attempts to over-express HtrA1 in MCF7 cells. In all attempts, no over-expressing clones could be obtained, so "re-expression" of HtrA1 in this context may produce cell death.

Proteases play essential roles in multiple biological processes. Beyond their functions in protein catabolism, proteases can selectively cleave substrates and thus influence cell behavior, survival, and death [@pone.0039446-Turk1]. For many years, proteases (especially extracellular) have been implicated in tumor progression, with the probably overly simplistic assumption that they can degrade extracellular matrix thus facilitating cell migration and invasion (see [@pone.0039446-Radisky1]). However, this assumption has not translated into clinical utility; in recent clinic trial studies, treatment of patients with broad-range metalloproteinase inhibitors showed no effects, or even produced an acceleration of tumor growth [@pone.0039446-Coussens1], [@pone.0039446-Overall1].


products were directly used for PCR and sequencing.

For amplification, the F1 and R1 is the primer pair designed on MethPrimer ([www.urogene.org/methprimer](http://www.urogene.org/methprimer)) was used. F1 is the forward primer 5′-TTTATTATTTTATTGTGGGTTTGGG, R1 is the reverse primer, 5′-AATAAAACTTTACAAAAAAACCCTAC, which amplifies the −561 to −266bp promoter region. Regions were sequenced 2 independent times. One used sequencing the PCR product directly, and the other time the products were cloned into TOPO vector, and the plasmid sample was then sequenced.

### Effects of decitabine and trichostatin A on HtrA1 expression {#s4b5}

MDA-MB-231, MDA-MB-468, MCF7, M4A4 cells were examined in these experiments. Decitabine (DEC) was from Tocris (Cat. No. 2624), and trichostatin A (TSA) was from Sigma (T8552). 5×10^5^ cells were plated in 6-cm plates for individual treatment, one day prior to treatment. For the experiment, DMSO,the statute of limitations. He argues that proceedings in mandamus were never regarded as an action at law, or a suit in equity, and are not, therefore, a civil action so as to be embraced within the statute of limitations.
It is unnecessary to decide whether this would be a proper case for the issuance of a writ of mandamus and whether this defendant is a proper person or entity to be served with such a writ. This is so, because, the writ of mandamus has been abolished by Rule 81(b) of the Federal Rules of Civil Procedure. Mandatory relief may now be obtained by means of a mandatory or an affirmative injunction. Wright and Miller, Federal Practice and Procedure: Civil § 3134. Rule 2 of the Federal Rules


same broad scope of due process protection as a criminal proceeding.
Degraffenreid v. State, 1979 OK
CR 88, ¶ 14, 599 P.2d 1107,
1110. The standard of review in acceleration proceedings is abuse of discretion.
Hagar v. State, 1999 OK CR 85, ¶ 10, 990 P.2d 894, 898; Edwards v.
State, 1987 OK CR 276, ¶¶
7-8, 747 P.2d 968, 970. There was
more than sufficient evidence presented at the acceleration hearing to find, by
a preponderance of the evidence, that Whitaker committed the offense of Domestic
Assault and Battery.
¶6 At Proposition 2, Whitaker argues that his sentence is excessive. The
State argues that the length of Whitaker's sentence is not proper for
consideration within the context of an acceleration appeal. Whitaker
acknowledges that the scope of reviewCourt reviewed a
claim of excessive sentence presented in a certiorari appeal. We noted
that in evaluating the validity of a guilty plea, the Court is concerned only
with whether the plea was entered voluntarily and intelligently. Frederick,
at ¶ 5, 811 P.2d at 602. Frederick admitted that his desire to withdraw his
plea was based primarily on his dissatisfaction with the sentence assessed in
his case. Finding that Frederick presented this Court with no compelling legal
reason to find that the trial court abused its discretion when it denied
Frederick's request to withdraw his plea, we affirmed the trial court's ruling.
Id. at ¶ 10, 811 P.2d at 604.
¶9 We acknowledge that the language in Frederick is unnecessarily
restrictive. We also note, however, that this Court has


GENERAL OF OKLAHOMAJUDY
      KINGASSISTANT ATTORNEY GENERAL313 N.W. 21st STREETOKLAHOMA
      CITY, OK 73105COUNSEL FOR THE STATE

OPINION BY: LUMPKIN, V.P.J.SMITH, P.J.: CONCURJOHNSON, J.:
CONCURLEWIS, J.: CONCUR

FOOTNOTES

1 A
review of the Tulsa County District Court docket reveals that on March 22, 2013,
Whitaker, represented by counsel, entered a guilty plea to a reduced charge of
misdemeanor Assault and Battery in Case No. CM-2013-407.

Citationizer© Summary of Documents Citing This Document

Cite
Name
Level

None Found.

Citationizer: Table of Authority

Cite
Name
Level

Oklahoma Court of Criminal Appeals Cases
 CiteNameLevel
 1987 OK CR 276, 747 P.2d 968, EDWARDS v. STATEDiscussed
 1988 OK CR 213, 762 P.2d 976, BEIHL v. STATEDiscussed
 1988 OK CR 276, 765 P.2d 794, VIGIL v. STATEDiscussed at Length
 1991 OK CR 56, 811 P.2d 601, FREDERICK v. STATEDiscussed
 1994 OK CR 9,embroidered trim, short sleeves with an openwork, netted and embroidered floral detail around each sleeve and across the front of the bodice. The same detail across the bodice is repeated 6" above the hemline.

Extra details: This is a cute black full skirted skater dress from Zara. The dress has a scoop neck line with short sleeves and epaulette straps on the shoulder. This is a stunning full skirted skater style dress from Zara!

New with tags. Midi jacquard dress with sequinned patches detail. Lapel collar with gems. Short sleeves. Back zip and hook and eye fastening. If you have any questions please do not hesitate to ask. Please view my other listings as well.


 -
 Meitetsu –  Komaki Line
  -  -  -
  Tōkai Transport Service Company- Jōhoku Line
  -
 Aichi Loop Railway - Aichi Loop Line

Highways
  Tōmei Expressway
  Chūō Expressway
  Nagoya Dai-Ni Kanjo Expressway(Meinikan)

Education

Colleges and universities:
 Chubu University
 Meijo University, Kasugai campus

Primary and secondary education:
 Kasugai has 37 public elementary schools and15 public junior high schools operated by the city government, and seven public high schools operated by the Aichi Prefectural Board of Education. There are also one private junior high schools and one private high school. The prefecture also operates two special education schools for the handicapped.

International schools:
  – North Korean school

Sister cities
  Kelowna, British Columbia, Canada from February 1981

Local attractions

Castle
 Jōjōnecessary to approve a peace deal.

Up to now, Netanyahu has been viewed mainly as a wily and intensely practical leader — but not as a visionary or a risk-taker. He talks tough — but tends to be measured in his actions. He maneuvers for short-term advantage and puts off difficult decisions until later. But sooner or later in any politician’s career, there comes a defining moment when history beckons and the time for prevarication runs out.

For Netanyahu, that moment may be coming soon. And what he does may surprise us.

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an integer (not an OID), and its OID would be determined by RFC 2576 translation rules. In the SMIv1 MIB I found, their version of linkDown is defined with ENTERPRISE "snmp", which (as Andrew says above) means they're rather redefining the standard trap in that MIB; they should have instead used their own ENTERPRISE OID, which would have made it unique.
RFC 2576 conversion rules require that traps with ENTERPRISE "snmp" be mapped to one of the standard OIDs. Per those rules, 1.3.6.1.2.1.11.0.2 would not be the correct OID for CISCO-GENERAL-TRAPS:linkDown, it would be the same as the standard (1.3.6.1.6.3.1.1.5.3).
That is, if the module imported (or otherwise defined "snmp" with the standard OID), but it doesn't, so I can only assume this is a modified version of the MIBEnda’s Speech

Image via WikipediaYes, Yet again I am impressed by a speech by Enda Kenny. It was overshadowed by someone elses speech though. The speech was given to commenerate the 90th Anniversary of the 1st Dáil.

Four score and ten years ago, on the 21st of January, the men and women of the 1st Dáil met here in this room. Their meeting sent out a message of independence, of courage and of hope to the peoples of the world. That message has been repeated by many leaders in many lands in the intervening decades. It will be repeated again today in another place by another young man carrying in his genetic make-up part of what makes our Irishness unique.

The first Dail’s meeting here marked a revolution: a revolution in


a Dáil which leads events rather than reacting to them.

But there are other things to reflect on today. There is for example the debt our democracy owes to those who were not present 90 years ago today – the old Irish party, the party of Parnell, Redmond and Dillon. It is easy to forget the enormous part they played in the shaping of Irish parliamentary democracy. For 40 years it was the voice of nationalist Ireland and for 40 years its goal was an independent Irish parliament. For all of this it got little thanks. The great Sean MacEoin, the ‘Blacksmith of Ballinalee’, expressed it well in 1938: “the old Sinn Fein members should apologise to the members of the old Irish Party…we blackguarded them up and down  self.config.items.tags[tag].forEach(function(dirname) {
          self.directories.push(dirname);
        });
      }
    });
  }
};

Gr.prototype.dirUnique = function() {
  var last;
  this.directories = this.directories.filter(Boolean)
                  .sort()
                  .filter(function(key) {
                    var isDuplicate = (key == last);
                    last = key;


WE ALL NEED A WEBSITE

We are in a time and season where access to vast of information on any field of enquiry is made possible through the internet compared to some 20 years back where information can be hoarded from public consumption and thereby monopoly of knowledge. But now , with the help of the internet, one can access any information on any field at any time without restriction. Thus, we are in a time where nobody can claim not to have access to any information that will enhance his or her life. The internet contains billions of web pages that are visible all over the world.
The internet helps in promoting ones business through personal websites from a local level to a global level that can be visibleencourage individuals, communities, employers, and governments to find ways to invest in the development of human beings and continue making vocational contributions to our lives together.

We deny that human worth and dignity is reducible to an individual’s economic contributions to society alone. Humanity should not use AI and other technological innovations as a reason to move toward lives of pure leisure even if greater social wealth creates such possibilities.

Genesis 1:27; 2:5; 2:15; Isaiah 65:21-24; Romans 12:6-8; Ephesians 4:11-16

Article 8: Data & Privacy

We affirm that privacy and personal property are intertwined individual rights and choices that should not be violated by governments, corporations, nation-states, and other groups, even in the pursuit of the common good. While God knows all things, it is neither wise nor obligatory to have every


Home decor ideas for the key leading decor II How can this eye-opening guide series with home decor ideas help you empower your home, garden or work space? Photo by Liana Mikah on Unsplash Introduction This is your 100% useful guide series on choosing and implementing...

Izidor Habjanič Dori landscape architect, interior designer, living space energy researcher, and publicist Home decor ideas for KEY LEADING DECOR How can this eye-opening guide with home decor ideas help you empower your living space, your home, garden or work space?...

This blog post is about the problem of ever-present sharp edges and corners in our homes. It should be read: if you are curious to learn facts about the great energy potential of living/working space and possibilities on how to trigger it withdecor idea for happy...

This blog post about Home Silk Road is: for readers curious to learn facts about great energy potential of living/working space and possibilities on how to trigger it for anyone interested in learning easy to follow practical tips/secrets on how to make some small...

Take a step toward exceptional living space 1. Approach your outdoor or indoor table. 2. Make a 360 degree check from this spot to determine your most beautiful view. This can be big nature screen (as seen on the Photo above, source:...


a style tag with custom CSS content
	 *
	 * @content The content to render out
	 * @sendToHeader Send to header or returned HTML content
	 */
	function addStyleContent( required content, boolean sendToHeader=false ){
		var str = '<style type="text/css">#arguments.content#</style>';
		if( arguments.sendToHeader ){
			$htmlhead( str );
		} else{
			return str;
		}
	}

	/**
	 * Add a js/css asset(s) to the html head section. You can also pass in a list of assets via the
	 * asset argument to try to load all of them.	You can also make this method return the string
	 * that will be sent to the header instead.
	 *
	 * If the setings: htmlHelper_js_path exists, we will use it as a prefix for JS files (Deprecated by 5.2)
	 * If the setings: htmlhelper_css_path exists, we will use it as a prefix for CSS Files (Deprecated by 5.2)
	* @queryString The query string to append, if needed.
	 * @title The title attribute
	 * @target The target of the href link
	 * @ssl If true, it will change http to https if found in the ses base url ONLY
	 * @noBaseURL Defaults to false. If you want to NOT append a request's ses or html base url, then set this to true
	 * @data A structure that will add data-{key} elements to the HTML control
	 */
	function href(
		href="",
		text="",
		queryString="",
		title=""
		target=""
		boolean ssl,
		boolean noBaseURL=false,
		struct data={}
	){
		var event	= controller.getRequestService().getContext();

		// self-link?
		if( NOT len( arguments.href ) ){
			arguments.href = event.getCurrentEvent();
		}

		// Check if we have a base URL and if we need to build our link
		if( arguments.noBaseURL eq FALSE and NOT find( "://", arguments.href ) ){
			// Verify SSL Bit
			if( isNull( arguments.ssl ) ){
				arguments.ssl = event.isSSL();
			}
			// Build it
			arguments.href =


spoof later.
		if ( arguments.method != "GET" AND arguments.method != "POST" ) {
			desiredMethod = arguments.method;
			arguments.method = "POST";
		}

		// self-submitting?
		if( NOT len( arguments.action ) ){
			arguments.action = event.getCurrentEvent();
		}

		// Check if we have a base URL and if we need to build our link
		if( arguments.noBaseURL eq FALSE and NOT find( "://", arguments.action ) ){
			// Verify SSL Bit
			if( isNull( arguments.ssl ) ){
				arguments.ssl = event.isSSL();
			}
			// Build it
			arguments.action = event.buildLink(
				to 			= arguments.action,
				ssl			= arguments.ssl
			);
		}

		// ID Normalization
		normalizeID( arguments );

		// Multipart Encoding Type
		if( arguments.multipart ){
			arguments.enctype = "multipart/form-data";
		} else {
			arguments.enctype = "";
		}

		// create tag
		flattenAttributes( arguments, "noBaseURL,ssl,multipart", formBuffer )
			.append( ">" );

		// If we wanted to use PUT, PATCH, or DELETE, spoof the HTTP method
		// by including a hidden field in the form that ColdBox will look for.
		if ( len( desiredMethod ) ) {
			formBuffer.append( "<input type=""hidden"" name=""_method"" value=""#desiredMethod#"" />" );
		}

		return formBuffer.toString();
	}

	/**
	 *label
	 * @bind The entity binded to this control, the value comes by convention from the name attribute
	 * @bindProperty The property to use for the value, by convention we use the name attribute
	 * @data A structure that will add data-{key} elements to the HTML control
	 * @inputInsideLabel If true, closes the label tag after the input tag and puts the label text after the input tag
	 */
	function checkbox(
		name="",
		value="true",
		boolean disabled=false,
		boolean checked=false,
		wrapper="",
		struct wrapperAttrs={},
		groupWrapper="",
		struct groupWrapperAttrs={},
		label="",
		struct labelAttrs={},
		labelWrapper="",
		struct labelWrapperAttrs={},
		labelClass="",
		bind="",
		bindProperty="",
		struct data={},
		boolean inputInsideLabel=false
	){
		arguments.type="checkbox";
		return inputField( argumentCollection=arguments );
	}

	/**
	 * Render out a radiobutton field. Remember that any extra arguments are passed as tag attributes
	 *
	 * @name The name of the textarea
	 * @value The value of the textarea
	 * @disabled Disabled
	 * @checked Checked
	 * @wrapper The wrapper tag to use around the tag.


are passed as tag attributes
	 *
	 * @src The image source
	 * @name The name of the textarea
	 * @disabled Disabled
	 * @wrapper The wrapper tag to use around the tag. Empty by default
	 * @wrapperAttrs Attributes to add to the wrapper tag. Empty by default
	 * @groupWrapper The wrapper tag to use around the tag and label. Empty by default
	 * @groupWrapperAttrs Attributes to add to the group wrapper tag. Empty by default
	 * @label If Passed we will prepend a label tag
	 * @labelAttrs Attributes to add to the label tag. Empty by default
	 * @labelwrapper The wrapper tag to use around the label. Empty by default
	 * @labelWrapperAttrs Attributes to add to the label wrapper tag. Empty by default
	 * @labelClass The class to be  = arguments.label,
					wrapper   = arguments.labelWrapper,
					labelMode =  2
				)
			); // close the label tag if we have one opened
		}

		// group wrapper?
		wrapTag(
			buffer,
			arguments.groupWrapper,
			1
		);

		return buffer.toString();
	}

	/**
	 * Render out a button. Remember that any extra arguments are passed as tag attributes
	 *
	 * @name The name of the textarea
	 * @value The value of the textarea
	 * @disabled Disabled
	 * @type The type of button to create: button, reset or submit
	 * @wrapper The wrapper tag to use around the tag. Empty by default
	 * @wrapperAttrs Attributes to add to the wrapper tag. Empty by default
	 * @groupWrapper The wrapper tag to use around the tag and label. Empty by default
	 * @groupWrapperAttrs Attributes to add to the group wrapper tag. Empty by default
	 * @label If Passed we will


getCache( "template" );
		var includesLocation 	= controller.getColdBoxSetting( "IncludesConvention" );
		var event 				= getRequestContext();
		arguments.currentModule = event.getCurrentModule();

		// Get the manifest location
		var manifestPath = 	discoverElixirManifest( argumentCollection=arguments );

		// Calculate mapping for the asset in question
		var mapping = ( arguments.useModuleRoot && len( arguments.currentModule ) ) ?
						event.getModuleRoot() :
						controller.getSetting( "appMapping" );

		// Calculat href for asset delivery via Browser
		if( mapping.len() ){
			var href = "/#mapping#/#includesLocation#/#arguments.fileName#";
		} else {
			var href = "/#includesLocation#/#arguments.fileName#";
		}
		var key = reReplace( href, "^//?", "" );

		// Only read, parse and store once
        var manifestDirectory = templateCache.getOrSet(
            "elixirManifest-#hash( manifestPath )#",
            function(){
				var contents = fileRead( manifestPath );
				if( isJSON( contents ) ){
					return deserializeJSON( contents );
				}
				return {};
      deduce all original constraints of the form . Namely, it is sufficient ensure that, for every $x_0,x_h\in\mathcal{X}$, there are $x_1,\ldots, x_{h-1}\in \mathcal{X}$ such that all constraints are in $\mathcal{C}$, for $ i=0,\ldots, h-1$. Then, to achieve the original level $\varepsilon$ of indistinguishability (i.e., of location privacy), it is sufficient to solve a new linear program with the same objective function and set of constraints $\mathcal{C}$. Note that in general the solution of the new program will give an utility inferior to the original one, because the constraints in $\mathcal{C}$ are stricter (i.e., enforce more privacy, due to the division by $\delta$) than the original constraints.

We construct $\mathcal{C}$ as follows: For every $x \in \mathcal{X} $, we consider all $x'\in \mathcal{X}$ such that $d(x,x')\leq R$, where $R$ is some


fixed distance. Then, for every $y \in\mathcal{X}$, we add a constraint of the form , where $x_i=x$ and $x_{i+1}=x'$. To make sure that we have enough elements in $\mathcal{C}$, we assume the following *density hypothesis*: Let $ch(\mathcal{X})$ be the *convex hull* of $\mathcal{X}$ (represented as points in the map, for instance, the centers of the cells). Then: $$\begin{aligned}
\label{eqn:hyp}
\forall y \in ch(\mathcal{X}) \;\; \exists x \in\mathcal{X} : d(y,x) \leq \rho\end{aligned}$$ where $\rho$ is some fixed distance. Note that to connect every pair of points in $\mathcal{X}$ it is necessary and sufficient to have $R\geq 2\rho$.

The execution time depends on the cardinality of $\mathcal{C}$, which, for fixed $R$, is $\mathcal{O}(n^2)$ ($n$ being the number of locations in $\mathcal X$). The cardinality of $\mathcal{C}$ is also proportional to $R^2$, so fromto the neuroleptics or to the antipsychotics categories were checked).

In this way, the entire literature on suicide in schizophrenia was carefully reviewed. By reviewing selected articles we identified some specific fields of interest. Sources of information also included original epidemiological research by the authors as well as classifications and data from World Health Organization. The authors agreed on a number of key topics relevant to the aim of this paper.

III. Results
============

1. Risk factors
---------------

There is almost total agreement that the schizophrenic patient who is more likely to commit suicide is young, male, white, and never married, with good premorbid function, post-psychotic depression and a history of substance abuse and suicide attempts. Hopelessness, social isolation, hospitalization, deteriorating health with a high level of premorbid functioning, recent loss or rejection, limited


external support, and family stress or instability are important risk factors in schizophrenic individuals who commit suicide. These patients usually fear further mental deterioration, and they show either excessive treatment dependence or loss of faith in treatment. Awareness of the illness has been reported as a major risk factor among schizophrenic patients who at risk of suicide. Protective factors also play an important role for assessing suicide risk and, therefore, should be carefully evaluated. Although there is a general consensus on these factors, proper knowledge and, therefore, early recognition of patients at risk is still lacking in everyday clinical practice.

Fenton et al. \[[@B20]\] and Fenton \[[@B21]\] described the high risk patient as a young male, with a history of good adolescent functioning and high aspirations, late age of= 0.50, 95%CI = 0.35--0.71. The authors argued that command hallucinations were not an independent risk factor, but they increased the risk in those already predisposed to suicide. Overall, suicide was less associated with the core symptoms of psychosis and more with affective symptoms, agitation, and awareness that the illness was affecting mental function.

The neurobiological perspective offers a new approach for understadinding self-destructive behavior among patients with schizophrenia and provides a basis for screening programs other than using the risk factors that are usually part of the clinical assessment. Low concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) are associated with suicidal behavior in patients with depressive illness and with schizophrenia. In a prospective study, Cooper et al. \[[@B31]\] measured 5-HIAA in the


been demonstrated that a blunted PRL secretion in response to D-FEN is associated with suicidal behavior in schizophrenic patients \[[@B33]\]. This is an important tool since this technique gives a specific indication of serotonergic function, and it can be combined with new neuroimaging paradigms such as PET and SPECT, providing images of seronergic function in vivo \[[@B34]-[@B37]\].

Plocka-Lewandowska et al. \[[@B37]\] found an association between results of the dexamethasone suppression test (DST) and suicide attempts in schizophrenic patients, suggesting a possible association between a hyperactive hypothalamo-pituitary-adrenal (HPA) axis and suicidal behavior in schizophrenic patients. Jones et al. \[[@B39]\] found that nonsuppression in the DST was associated with suicidal behavior in a sample of schizophrenic patients, and non-suppression of the DST differentiated suicide attempters from non-attempters. Reports of an associationand, for this reason, an examination of risk factors for attempted suicide in schizophrenia is important. A recent systematic review of the risk factors for attempted suicide in schizophrenia identified only 14 studies that met selection criteria \[[@B47]\]. These authors examined 29 variables that were studied in at least two or more studies and found only five significant variables: past suicidal ideation, previous deliberate self harm, previous depressive episodes, drug abuse or dependence, and a higher mean number of psychiatric admissions

Great caution is required during the period after hospital discharge because patients with schizophrenia usually experience hopelessness and demoralization during this time. For these patients, discharge often means losing the hospital environment and the people who in some way have become central in their life. The number of


group with a history of suicidality had significantly higher levels of both general awareness of illness and hopelessness. However, when hopelessness and insight were entered into a multiple regression model, along with several other variables, only hopelessness was statistically significant. In the second study, Bourgeois and colleagues \[[@B60]\] analyzed data from 980 patients from the International Suicide Prevention Trial (InterSePT) \[[@B61]\]. The results were similar to those of Kim et al. \[[@B59]\]. Greater awareness of illness significantly predicted suicide risk when entered independently into the model (with better insight associated with increased suicide risk), but was no longer significant once hopelessness was entered into the equation. Interestingly, the baseline level of awareness was associated with increased risk for suicidal behavior, but improvement in awareness over the follow-up periodsubstance use disorders is very frequent \[[@B113]\], and a typology based on the additional presence or absence of an addictive disorder could be meaningful, the more so as drug misuse or dependence considerably increases the risk of suicide \[[@B30]\].

Some other suicide subtypes have been described in schizophrenic disorders, but they have been only clinically inferred and not empirically tested. Based on their study of psychotic inpatients and their behavior in the psychiatric hospital setting, Farberow et al. \[[@B100]\] proposed three subtypes of schizophrenic suicide: (1) the unaccepting, grossly disturbed patient resisting hospitalization; (2) the dependent, satisfied patient whose suicide outside the hospital appears to be a consequence of stressful conflict and ambivalence concerning the home environment; and (3) the dependent, dissatisfied, demanding patient who has no other place


e. Comorbid substance use disorders

Substance use/abuse/dependence is often comorbid with schizophrenia, and psychosis and substance use are both found to increase suicide risk \[[@B150]\]. Researchers, in studies of two American cohorts, found significantly more comorbid substance abuse among people with schizophrenia who were suicidal, particularly among the younger ones \[[@B151]-[@B153]\]. They stated that it is important, in view of the changing patterns in the epidemiology of schizophrenia comorbid with substance use/abuse, that clinicians obtain accurate drug-use history in order to detect and promptly treat drug use/abuse. Youths who abuse drugs are at increased risk for committing suicide, and drug or alcohol abuse is found in about 70% of children and adolescents who commit suicide \[[@B154]\].

Harris and Barraclough\'s \[[@B10]\] meta-analysis on suicide as outcome in mental disorders reported onof suicide in the general population \[[@B151],[@B170]-[@B173]\] and, when this behavior is associated with a diagnosis of schizophrenia, the risk is much higher. It is also important to take into consideration the difficulties in reaching marginalized individuals. A comparison of patients who began drug abuse before their first admission with those who began abusing drugs after their first admission showed that the use of specific drugs was associated with significant differences in age, age at first hospitalization, premorbid functioning and subtype of schizophrenia. The differences were not uniform across the different drugs \[[@B174]\].

But, when comparing schizophrenics who attempt suicide with nonattempters, drug abuse is not found to differ between the two groups \[[@B69]\]. However, schizophrenic patients who use substances do have more positive symptoms, especially hallucinations \[[@B175]\], and


who have treated the individual, even in cases in which the victim was known to be strongly self-destructive. The feeling of concern evoked by self-destructive persons in those with whom they are in contact disappears or is absent immediately prior to suicide. According to Tähkä \[[@B206]\], this is because, after the final decision to commit suicide, the person ceases to send emotional messages. When the person no longer hates anybody but himself, then someone\'s love and concern no longer prevents him. The narcissistic regression has reached a point at which the person has lost his object-orientedness. Loss of concern by professionals is also associated with an acute risk of suicide in depressed schizophrenics \[[@B25]\].

Maltsberger \[[@B207]\] has noted that severely self-destructive persons cannot be reached by means of empathywho are depressed, substance abusers and hopeless should be monitored carefully. Those who have experienced multiple hospitalizations and previously threatened or attempted suicide should be treated with adequate procedures, such as programs of aftercare and psychosocial intervention.

Tertiary prevention is addressed to those individuals who have attempted suicide or have been suicidal in the past. Destigmatisation should be addressed to mental illness as well as suicide. Increasing the stigma associated with having suicidal feelings will increase the suicide rate. Interventions among families, mental health professionals and church activists aimed at decreasing the stigma associated with mental illness and suicide may contribute to the reduction of deaths by suicide. Pharmacological interventions are no doubt of paramount importance, but psychosocial interventions and psychoatherapy also play a central role.

This review has several


limitations. It does not present mata-analytic results, and the authors adopted a narrative approach in order to summarise the information regarding suicide in schizophrenia. However, contributions were provided by scholars with an international reputation in this field. For this reason, this review differs from previous reviews and represents an original consensus conference approach from many authors who provided, on the basis of their expertise, a brief essay on specific aspects of the problem. References selected for this study may not include all of the works dedicated to the topic. Other key works may be available and may provide further understanding of the topic. Clearly, more joint efforts of this kind are needed to develop sound, shared guidelines for the prevention of suicide among individuals affected by schizophrenia.

Acknowledgements
================

The authorscomplex and quantitative phenotypes, such as those that apply costly neuroimaging, this approach can be particularly advantageous.

We investigated the sample size requirement of this approach and the cost-effectiveness under different scenarios.

Methods {#Sec2}
=======

The sample size requirements depend on the proportion of variance explained by the genetic effect, allele frequencies, and the genetic model (Falconer and Mackay [@CR2]). In our description of the genetic model, we follow Falconer's notation, in which the mean genotypic values of the A~1~A~1~, the A~1~A~2~, and A~2~A~2~ genotypes are denoted as +a, d, and −a, respectively. The total variance of a phenotype (V~P~) can be broken down into the variance due to one particular locus (V~G~), and the remaining genotypic and environmental variance V~R~. V~G~ can be further divided into the additive genetic (V~A~) and


{ 2 {\text{pq}}} \right)^{ 2} \left( {{\text{d}}/{\text{a}}} \right)^{ 2} } \right)}}} \right. \kern-\nulldelimiterspace} {\left( { 2 {\text{pq}}\left( { 1 + {\text{d}}/{\text{a}}\left( {{\text{q}} - {\text{p}}} \right)} \right)^{ 2} + \left( { 2 {\text{pq}}} \right)^{ 2} \left( {{\text{d}}/{\text{a}}} \right)^{ 2} } \right)}}} \right]^{0. 5} $$\end{document}$$Based on the chosen values of p, q, d/a, V~G~, the total number of selected individuals (N), and the selected number of individuals from each genotype group, we can derive the statistical power from a calculation of the F statistic. In order to calculate the F statistic, we first calculated the total mean, the within-group means, the within-group sum of squares (ss~within~) and the between-group sum of squares (ss~between~). The within-group means of the three genotype groups do not change as a result of selection andexplained by the genotype increases (Fig. [7](#Fig7){ref-type="fig"}).Fig. 1Power achieved under different sampling strategiesFig. 2Power for a sampling strategy where three genes were selected and subjects were available that were homozygous for two of the rare homozygous variants and heterozygous for the third variant compared to subjects that were homozygous for all three common variantsFig. 3The power of sampling strategies under different assumptions of explained varianceFig. 4The power of sample strategies under different assumptions of dominanceFig. 5The power of sample strategies under different assumptions of allele frequenciesFig. 6The costs as a function of phenotype/genotype cost ratio under different allele frequenciesFig. 7The costs as a function of explained variance by the sequence variant under different phenotype/genotype costs ratios

Discussion {#Sec4}
==========

We have demonstrated that "forward genetics" is a cost-effective method for investigating genotype--phenotype associations in complex human traits. The figures,


in order to avoid phenotyping bias and ethical complications. The classical approach would be to assess a large numbers of participants from the epidemiological study and to perform a case--control association analysis or quantitative trait locus (QTL) analysis. As pointed out above, the costs of assessing the large numbers of participants required in the conventional design would be much higher compared to the forward genetics approach. Particularly in cases where the genetic variant is rare and many assessments would be required to obtain sufficient power.

Our approach differs from the recently advocated "reverse phenotyping" approach (Schulze and McMahon [@CR7]), in which both genotype and phenotype information is assumed to be available. The phenotype--genotype relationship is, however, re-assessed by revisiting phenotypes (reverse phenotyping). Clearly, a strong argument for Schulze andetc. Here are some of the things that you should consider if you are going on this adventure.

Speciality

The medical industry is absolutely enormous and there are literally hundreds of different jobs or specialists. This can include things such as doctors, dentists, opticians, consultants and nurses. It would be very brave for you to start off being a master of all trades therefore it may be wise for you to dedicate your facility to one or two of these. You should have a good look at the demand for these specialists in your area and if there are any more of these specialists medical facilities in the area that would be competition to you.

Recruitment

Recruiting medical staff is not as easy as you would think. This is mainly down to


Police in Arkansas have arrested a woman on DWI charges after she allegedly tried to flee the scene of a car accident in a battery-powered children’s toy truck.

Initially, 29-year-old Jamie Jeanette Craft crashed into a mobile home in her 2001 Pontiac Grand Am. But local affiliate KAIT8 reports that Craft then attempted to drive away from the scene in a very different vehicle: a Power Wheels children’s truck.

The Fisher-Price Power Wheels vehicles are made to resemble real-life, adult vehicles, including a Ford Mustang and a Jeep Wrangler. But some models are purely imaginative, including one model that is built to resemble the “Lightning McQueen” character from the Pixar movie “Cars.”

When the owner of the mobile home went back outside after checking on his grandchildren, he said Craft wasalcohol or consume any narcotics while at the hotel."

Investigators concluded Jenkin's death was accidental after retracing her path to the cooler that contained the freezer where her body was found, reviewing hours of surveillance video and interviewing most of the people that were at the party that night.

"There is no evidence that indicates any other conclusion," Stephens said.

Read More


July 3, 2010

It is late and I should be sleeping, but I am too excited to get this sneak peek up for this amazing couple. I am just getting back from shooting this phenomenal wedding. I have several people to mention and amazing photos of this beautiful venue to write and post about, but for now, I will post a few of my favorites. Much more to come and I can't wait to show off the beautiful venue photos.

A fun, more modern composition. Love it!

Amazing light! I kept telling E and M how happy I was to be shooting in such gorgeous light!

Father and daughter. What a sweet moment.

I will end with my favorite image. Beautiful light, beautiful bride, what more can you ask for!

Great meeting you andas part of writing thread-safe code.
Rather than using locks to synchronize interaction with an object (see the Synchronization section of the Threading Programming Guide), one can use a serial queue (see the Eliminating Lock-Based Code section in the Migrating Away from Threads chapter of the Concurrency Programming Guide).
Glancing at the code, this would appear to be the author's intent (as it appears that all interaction with this object happens on that serial queue). Assuming this is the case, when using serial queues to facilitate synchronization as part of a broader thread-safe app design, it's prudent to dispatch all interaction with the object in question to the designated serial queue, regardless of how trivial the dispatched code looks. It might not be strictly necessary to do this in all


This is one of mine that got featured ages ago, but would love to hear it, like a forties radio play noir thing, even if you want to abridge it. If you think it's up to it that is! Don alun 17:22, 23 October 2007 (UTC)

I'll do it, but it may take a week, I want to do a good jobs with all the sound effect things, I'm only going to do the first section, and then do a coming up next week thing. My recording computer JUST got fixed, so I should have a more recordings soon! - UnIdiot| | Talk | Contribs-18:43, Oct 23number of cells high enough for clinical applications and sustainable enough to be applied for cell tracking over a long time but with the least possible impact on cell biology.

Materials and Methods {#s002}
=====================

Cell cultivation {#s003}
----------------

Primary AD-hMSCs^[@B29]^ were isolated and identified by immune phenotype and functional characteristics as defined by the International Society for Cellular Therapy^[@B5]^ comprising the presence of CD105, CD73, and CD90, and the absence of CD45, CD34, CD14 or CD11b, CD79α or CD19, and human leukocyte antigen DR isotype (HLA-DR) surface molecules. Cells in passage 2 were cultivated at 37°C in complete medium (minimum essential medium eagle alpha medium; Gibco, Germany), 10% human serum AB ([c.c.pro](c.c.pro) GmbH, Germany), 0.5% gentamycin (Biochrom, Germany) in a T175 culture flask (Sarstedt, Germany) in humidified atmosphere (5% CO~2~/21% O~2~). At


to centuries.
0.0156134375
Convert 5381.21 nanometers to millimeters.
0.00538121
Convert 5726.69l to millilitres.
5726690
Convert 7.540944 micrometers to centimeters.
0.0007540944
How many millilitres are there in 5/4 of a litre?
1250
Convert 112.55076 milliseconds to hours.
0.0000312641
How many kilograms are there in three fifths of a tonne?
600
What is 11/4 of a microgram in nanograms?
2750
What is 4359.63 grams in milligrams?
4359630
What is eleven eighths of a microgram in nanograms?
1375
What is 4632.172 weeks in milliseconds?
2801537625600
How many millimeters are there in 64615.3cm?
646153
What is 25/2 of a meter in millimeters?
12500
Convert 85.55453mm to centimeters.
8.555453
How many millimeters are there in 1.648624km?
1648624
Convert 3.5071cm to kilometers.
0.000035071
Convert 312057.8 centuries to millennia.
31205.78
How many minutes are there in 64/5 of a hour?
768
Convert 5045.864 meters to micrometers.
5045864000
What is 1.80876m in centimeters?
180.876
What      parent.appendRow(it)
            parent = it
    w.setModel(model)

    view = QtWidgets.QTreeView()
    w.setView(view)
    w.show()
    sys.exit(app.exec_())

A more elegant solution is to overwrite the flags of the model:
import sys

from PyQt5 import QtWidgets, QtGui, QtCore

class StandardItemModel(QtGui.QStandardItemModel):
    def flags(self, index):
        fl = QtGui.QStandardItemModel.flags(self, index)
        if self.hasChildren(index):
            fl &= ~QtCore.Qt.ItemIsSelectable
        return fl

if __name__ == '__main__':
    app = QtWidgets.QApplication(sys.argv)
    w = QtWidgets.QComboBox()
    model


a fairly hands-on role in the game’s development.

Dragon Quest Heroes will also feature a number of arrangements from other Dragon Quest games and classic sounds such as the level up chime will be included as well.

Lastly, Horii confirmed the next numbered entry in the series is also in development, although first he would like you to play Dragon Quest Heroes to build up a little bit of excitement before that next title comes out.

Dragon Quest Heroes is launching on both PS3 and PS4 in Japan by Spring 2015.of classical and non-classical NFκB stimulators (**a**) and a dose response of Ltα1/β2 (**b**) in NSCs/NPCs. Dissociated NSCs/NPCs cultured from adult mouse brain subventricular zones (SVZ) were plated on 96-well plate and infected with adenovirus carrying NFκB *firefly*-luciferase at 50 multiplicity of infection for 24 h and treated with indicated cytokines for 24 h. Luciferase activity was measured using OneGlo luciferase kit. Data are expressed as relative fold changes compared with corresponding control. **c**, **d** Western blot analysis of nuclear extracts from SVZ NSCs/NPCs for the nuclear translocation of non-classical (RelB, p52) and classical (p65) NFκB pathways. NSCs/NPCs were treated with indicated cytokines for 4 h before preparation of nuclear extracts. TNF: tumor necrosis factor; LT: lymphotoxin; IL: interleukin. Lamin A/C served as nuclear protein loading control

LTβR expression exists in neural


All authors read and approved the final manuscript.

Funding {#FPar2}
=======

This work was supported by the National Institute of Health R01-MH101041 and R01-DK075964 (WH).

Availability of data and materials {#FPar3}
==================================

The data and research materials are available from the corresponding authors upon a reasonable written request.

Ethics approval {#FPar4}
===============

All procedures for animal usage were complied with the guidelines of the National Institutes of Health and approved by the Institutional Animal Care and Use Committee (IACUC) at Temple University (Approval number 4324).

Consent for publication {#FPar5}
=======================

Not applicable.

Competing interests {#FPar6}
===================

The authors declare that they have no competing interests.

Publisher's Note {#FPar7}
================

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
&& library.equals(rlibrary)) { // Set the context to record script as included return true; } } iter = (viewRoot.getComponentResources(ctx, "body")).listIterator(); while (iter.hasNext()) { UIComponent resource = (UIComponent)iter.next(); String rname = (String)resource.getAttributes().get("name"); String rlibrary = (String)resource.getAttributes().get("library"); if (name.equals(rname) && library.equals(rlibrary)) { // Set the context to record script as included return true; } } iter = (viewRoot.getComponentResources(ctx, "form")).listIterator(); while (iter.hasNext()) { UIComponent resource = (UIComponent)iter.next(); String rname = (String)resource.getAttributes().get("name"); String rlibrary = (String)resource.getAttributes().get("library"); if (name.equals(rname) && library.equals(rlibrary)) { // Set the context to record script as included return true; } } return false; }

I was looking through the JSF API and Implementation code, and found a gem that really demonstrates how to add a Javascript framework, or custom Javascript code to your custom JSF component.It requires more than writing


Rise Records with two singles including "Haunted House" and "They Call Me Steve".

On November 3, 2015, drummer Brandon Carlisle was found unresponsive in his Fort Collins home by his roommate. On November 7, the band's Twitter page confirmed he had died in his sleep the night before after being taken off life support.

On January 18, 2016, Darren Chewka of Old Wives was announced as the band's new drummer.

They returned to Fat Wreck Chords in 2017, releasing Stealing the Covers, a full-length album consisting entirely of cover songs by obscure bands. A 7-inch, Goin' Back to Wyo, was released in conjunction with the album, and consisted of two new original songs.

Band membersCurrent members Ray Carlisle – bass guitar, lead vocals (2000–2006); rhythm and lead guitar, lead vocals (2006–present)
 Kody/**
 * Licensed to the Apache Software Foundation (ASF) under one
 * or more contributor license agreements.  See the NOTICE file
 * distributed with this work for additional information
 * regarding copyright ownership.  The ASF licenses this file
 * to you under the Apache License, Version 2.0 (the
 * "License"); you may not use this file except in compliance
 * with the License.  You may obtain a copy of the License at
 *
 *     http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing


    .curve(curveBasis)(points);
            },
            intersectRect: (node, point) => {
                var x = node.x,
                    y = node.y,
                    dx = point.x - x,
                    dy = point.y - y,
         // if (platform.name === "IE") {
        //     LineageUtils.refreshGraphForIE({ edgePathEl: edgePathEl });
        // }
    },
    /**
     * [getToolTipDirection description]
     * @param  {[type]} options.el [description]
     * @return {[type]}            [description]
     */
    getToolTipDirection: function ({ el }) {
        var width = select("body").node().getBoundingClientRect().width,
            currentELWidth = select(el).node().getBoundingClientRect(),


direction = "e";
        if (width - currentELWidth.left < 330) {
            direction = width - currentELWidth.left < 330 && currentELWidth.top < 400 ? "sw" : "w";
            if (width - currentELWidth.left < 330 && currentELWidth.top > 600) {
                direction = "nw";
            }
        } else if (currentELWidth.top > 600) {
            direction = width - currentELWidth.left < 330 &&[description]
     * @param  {[type]} options.onExportLineage  [description]
     * @return {[type]}                          [description]
     */
    saveSvg: function ({ svg, width, height, downloadFileName, onExportLineage }) {
        var that = this,
            svgClone = svg.clone(true).node(),
            scaleFactor = 1;
        setTimeout(function () {
            if (platform.name === "Firefox") {


U.S. Office of Management and Budget (OMB) Director Mick Mulvaney (R) listens as U.S. President Donald Trump (L) meets with members of the Republican Study Committee at the White House in Washington, U.S. March 17, 2017. REUTERS/Jonathan Ernst

WASHINGTON (Reuters) - President Donald Trump, who has proposed cuts to an array of government agencies, is asking department heads to offer up plans to operate more efficiently.

Trump’s budget director, Mick Mulvaney, told reporters on Tuesday he would be instructing agencies to outline how they will comply with the president’s budget, which slashed spending for foreign aid and many domestic programs.

The federal hiring freeze imposed shortly after Trump entered office will be lifted on Wednesday, but agencies will be asked to remain mindful of Trump’s goal to reduce the federal workforce,operation.
func (client GroupsClient) CreateOrUpdate(resourceGroupName string, parameters ResourceGroup) (result ResourceGroup, err error) {
	if err := validation.Validate([]validation.Validation{
		{TargetValue: resourceGroupName,
			Constraints: []validation.Constraint{{Target: "resourceGroupName", Name: validation.MaxLength, Rule: 90, Chain: nil},
				{Target: "resourceGroupName", Name: validation.MinLength, Rule: 1, Chain: nil},
				{Target: "resourceGroupName", Name: validation.Pattern, Rule: `^[-\w\._\(\)]+$`, Chain: nil}}},
		{TargetValue: parameters,
			Constraints: []validation.Constraint{{Target: "parameters.Properties", Name: validation.Null, Rule: false,
				Chain: []validation.Constraint{{Target: "parameters.Properties.ProvisioningState", Name: validation.ReadOnly, Rule: true, Chain: nil}}},
				{Target: "parameters.Location", Name: validation.Null, Rule: true, Chain: nil},
				{Target: "parameters.ID", Name: validation.ReadOnly, Rule: true, Chain: nil}}}}); err != nil {
		return result, validation.NewErrorWithValidationError(err, "resources.GroupsClient", "CreateOrUpdate")
	}

	req, err := client.CreateOrUpdatePreparer(resourceGroupName, parameters)
	if err != nil {
		return result, autorest.NewErrorWithError(err, "resources.GroupsClient", "CreateOrUpdate", nil, "Failure preparing request")
	}

	resp, err := client.CreateOrUpdateSender(req)
	if err != nil {
		result.Response = autorest.Response{Response: resp}
		return result, autorest.NewErrorWithError(err, "resources.GroupsClient", "CreateOrUpdate", resp, "Failure sending request")
	}

	result, err = client.CreateOrUpdateResponder(resp)
	if err != nil {
		err = autorest.NewErrorWithError(err, "resources.GroupsClient", "CreateOrUpdate", resp, "Failure responding to request")
	}

	return
}

// CreateOrUpdatePreparer prepares the


result, autorest.NewErrorWithError(err, "resources.GroupsClient", "List", nil, "Failure preparing request")
	}

	resp, err := client.ListSender(req)
	if err != nil {
		result.Response = autorest.Response{Response: resp}
		return result, autorest.NewErrorWithError(err, "resources.GroupsClient", "List", resp, "Failure sending request")
	}

	result, err = client.ListResponder(resp)
	if err != nil {
		err = autorest.NewErrorWithError(err, "resources.GroupsClient", "List", resp, "Failure responding to request")
	}

	return
}

// ListPreparer prepares the List request.
func (client GroupsClient) ListPreparer(filter string, top *int32) (*http.Request, error) {
	pathParameters := map[string]interface{}{
		"subscriptionId": autorest.Encode("path", client.SubscriptionID),
	}

	queryParameters := map[string]interface{}{
		"api-version": client.APIVersion,
	}
	if len(filter) > 0 {
		queryParameters["$filter"] = autorest.Encode("query", filter)
	}
	if top != nil {
		queryParameters["$top"] = autorest.Encode("query", *top)
	}

	preparer := autorest.CreatePreparer(
		autorest.AsGet(),
		autorest.WithBaseURL(client.BaseURI),
		autorest.WithPathParameters("/subscriptions/{subscriptionId}/resourcegroups", pathParameters),
		autorest.WithQueryParameters(queryParameters))
	return preparer.Prepare(&http.Request{})
}

// ListSender sends the List request. The method will close the
// http.Response Body if it receives an error.
func (client GroupsClient) ListSender(req *http.Request) (*http.Response, error) {
	return autorest.SendWithSender(client, req)
}

// ListResponder handles the response to the List request. The method always
// closes the http.Response Body.
func (client GroupsClient) ListResponder(resp *http.Response) (result ResourceGroupListResult,amoxicillin. Compared with the quantification of sIgE antibodies, BAT shows a comparable sensitivity and specificity. As for sIgE, sensitivity of BAT to β-lactams is rather low and decreases over time \[[@CR26]\].Table 1Specific IgE to β-lactam antibioticsCompoundRef. testAssaySensitivitySpecificity*N*Ref.Various β-lactamsH + STCAP-FEIABPO + AXO + peni G + AMP: 31.8%BPO + AXO + peni G + AMP: 88.6%58\[[@CR111]\]Various β-lactamsH + ST + DPTCAP-FEIABPO: 32%\
AXO: 43%\
BPO + AXO: 50%BPO: 98%\
AXO: 98%\
BPO + AXO: 96%129\[[@CR112]\]Various β-lactamsH + ST + DPTCAP-FEIABPO: 10--68%\
AXO: 41--53%BPO: 98%\
AXO: 95%410\[[@CR25]\]Various β-lactamsHCAP-FEIA37.9%86.7%58\[[@CR113]\]Various β-lactams^a^H + ST + DPTCAP-FEIA\
RAST^b^0--25%^b^\
42.9--75%^b^83.3--100%^b^\
66.7--83.3%^b^45\[[@CR21]\]Various β-lactamsH + STCAP-FEIA\
CAP-FEIA85%^c^\
44%^d^54%^c^\
80%^d^176\[[@CR29]\]Various β-lactamsH + STCAP-FEIA66%52%293\[[@CR30]\]*AMP* ampicillin, *AXO* amoxicillin, *BPO* benzyl penicilloyl, *CAP*-*FEIA* fluorescence enzyme immunoassay (available from Phadia Thermo Fisher), *DPT* drug provocation test, *H* history, *IgE* immunoglobulin E, *N* number, *peni G* penicillin G, *RAST* radio allergo sorbent test, *Ref*. reference, *ST* skin test^a^Home-made assay^b^Sensitivity and specificity vary according to clinical manifestations^c^For a threshold of 0.10 kUA/L^d^For a threshold of 0.35 kUA/L Table 2BAT in immediate β-lactam hypersensitivityStimulusRef. testActivation markerSensitivity (%)Specificity (%)Number of patients and controlsRef.β-LactamHCD63509388\[[@CR113]\]β-LactamH + DPTCD63399353\[[@CR114]\]β-LactamH + ST + IgE + DPTCD634991110\[[@CR115]\]AmoxicillinH + STCD203c\
CD6352\
22100\
7941\[[@CR116]\]β-LactamHCD635089--97262\[[@CR117]\]β-LactamH + ST + IgECD63-CCR3\
CD63-IgE55\
5310039\[[@CR118]\]AmoxicillinHCD6329--14


counter and semiconductor integrated circuit device incorporating the clock counter therein) of transferring clock information, that is generated at a clock counter, to a display system driver section by a DMA (Direct Memory Access) section, and carrying out clock display.
When carrying out clock display by the above-described conventional LCD clock display circuit, the CPU 101 always receives an interruption request from the real-time clock circuit 105 at a fixed cycle. Therefore, at the conventional LCD clock display circuit, even in a halt mode, i.e., even when the clock supply to the CPU 101 is stopped and the CPU 101 is in a state in which operation thereof is suspended, there is the need to come out of the halt mode and transition to the usual operation mode byThe Future of JavaScript MVC Frameworks

Introducing Om

often devs still approach performance of JS code as if they are riding a horse cart but the horse had long been replaced with fusion reactor — Vyacheslav Egorov (@mraleph) December 13, 2013

We’ve known this for some time over here in the ClojureScript corner of the world - all of our collections are immutable and modeled directly on the original Clojure versions written in Java. Modern JavaScript engines have now been tuned to the point that it’s no longer uncommon to see collection performance within 2.5X of the Java Virtual Machine.

Wait, wait, wait. What does the performance of persistent data structures have to do with the future of JavaScript MVCs?

A whole lot.

We’ll see how, perhaps unintuitively, immutable data allows a new library,


hood) will deliver an optimal balance between simplicity, performance, and expressivity. There’s nothing special here that hasn’t been known for a long, long time. If you treat the browser as a remote rendering engine and stop treating it as a place to query and store crap, everything gets faster. Sound like something familiar? Yeah, computer graphics programming.

Expect more posts in the future elaborating ideas I’ve only hinted at or haven’t mentioned: VCR playback of UI state, trivial UI instrumentation, client/server template sharing, relational user interfaces, and much more.

Thanks

I would not have written this post or written Om if wasn’t for the following people.

Brandon Bloom has been bugging me for many months to give React a closer look. Sadly I didn’t give it a proper chance until I sawPeter Hunt’s JSConf EU 2013 presentation, which explained the architecture.

Thanks to Kovas Boguta for humoring and encouraging me through several Om design discussions.

Thanks to Jordan Walke for inadvertently giving me the original inspiration to try something like Om via a Twitter conversation and to Peter Hunt and Ben Alpert and the other super friendly people on the React IRC channel for answering my numerous questions. Without the great technology that is React none of the above would have been possible.


Since copper can promote DC oxidation to the respective DC disulfides, the inhibitory effect on lymphocyte apoptosis might be mediated by the DC disulfides. In agreement with this we observed that DC disulfides were more potent inhibitors of T cell apoptosis than their reduced counterparts. Inhibition of apoptosis by DC disulfides correlated with the inhibition of caspase-3 proenzyme processing and activation. Similar results were obtained in a cell-free model system of caspase-3 activation. Significantly, dithiothreitol reduction of the DC disulfide abolished its inhibition of in vitro proenzyme processing, thereby demonstrating thiol-disulfide exchange between the DC disulfide and a free thiol group on an activator(s) of caspase-3. Since T cell apoptosis involves the generation of mature caspase-3 and requires caspase-3-like activity, we propose that (1) DC disulfides are the                      2
   Case: 11-20908   Document: 00512036373      Page: 3   Date Filed: 10/29/2012

                                  No. 11-20908

renewed for an additional five-year term. Correspondingly, Mutual Concepts
and FNB entered into a new Affinity Agreement, which superseded the earlier
agreement. Significantly, the 2003 Agreement retained a requirement that FNB
pay Mutual Concepts “so long as this Agreement is in effect,” but deleted an
earlier provision which specified that compensation would terminate at the
cancellation


 II. Standard of Review
      We review the sufficiency of evidence with great deference to the jury
findings and verdict in the court below. Bagby Elevator Co. v. Schindler Elevator
Corp., 609 F.3d 768, 773 (5th Cir. 2010). As long as there is a “legally sufficient
evidentiary basis for a reasonable jury to find as the jury did,” the jury verdict
must be upheld. Goodner v. Hyundai Motor Co., 650 F.3d 1034, 1039-40 (5th
Cir. 2011) (quoting Foradori v. Harris, 523 F.3d 477, 485 (5th Cir. 2008)). The
court will reverse “only if the evidence points so strongly and overwhelmingly in
favor of one party that the court believes that reasonable jurors could not arrive
at any contrary conclusion.” Bagby, 609 F.3d at 773 (internal quotation marks
and citation omitted).
  the merits of such an argument in the
abstract—and without reaching the question of whether this argument is waived
by failing to raise it in a Rule 50 motion—we conclude it is inapposite here. The
conduct underlying any alleged “breach” by revealing confidential information
was, at best for FNB, a question of fact that should have been (and was) resolved
by the jury in its determination of the breach and excuse questions. We disagree

                                        4
     Case: 11-20908    Document: 00512036373


Page: 5     Date Filed: 10/29/2012

                                      No. 11-20908

that the evidence is such that no other conclusion can be reached but that the
alleged breach occurred and was material. We decline to conclude “as a matter
of law” that Mutual Concepts is not entitled to recover on the breach of contract
found by the jury.1
B.      Attorney’s Fees
        The attorney’s fees question is more complex. The Affinity Agreement
contains a choice-of-law provision choosing Nebraska law. Under Nebraska law,
attorney’s fees are not recoverable Document: 00512036373         Page: 7     Date Filed: 10/29/2012

                                      No. 11-20908

under Nebraska law, then, is simply in support of this public policy. Absent a
Nebraska statute awarding attorney’s fees, attorney’s fees are not recoverable.
       We recently examined a similar situation in Provident Financial, Inc. v.
Strategic Energy L.L.C., determining whether Texas or Pennsylvania law
applied to the award of attorney’s fees in a breach-of-contract dispute under
Pennsylvania law. 404 F. App’x 835, 839 (5th Cir. 2010) (unpublished). The
difference


steps to get a pre-exsisting c++ project working in REDHAWK.  This answer does not cover getting the library to build or the process of importing it into eclipse as there are numerous posts on these topics:

Import the library into your IDE.
Build your shared library so that you have a shared object (.so file)
Add a .spd.xml file to your library such as the one found here.
Edit this .spd.xml file:

4a.  Update the localfile tag to point to the location of your specific .so file.
4b.  Ensure that the value of the implementation id tag is a unique revision number for your library

Add a .project file if it doesn't exist such as the one found found here. Open your .project file and ensure that the following natures areincluded:
<nature>gov.redhawk.ide.natures.sca.project</nature>
<nature>gov.redhawk.ide.natures.sca.component</nature>

You should now be able to drag your sofpackage library to the SDR root.

Here are the steps to update your individual components you are building to make use of your new library:

Edit the components Makefile.am in the cpp implementation folder.  Edit the _CXXFLAGS to add the path to your header files, _LDADD to add your library, and _LDFLAGS to include the path to your library.  See this example for how the agc component modifies these variables to include the dsp library.
Edit the .spd.xml file to include the softpackage dependency.  Under the implementation section add a run time dependency on your library  such as the one found here.  Specifically - your dependency section should be as follows:
<dependency type="runtime_requirements">
  <softpkgref>


/**
 * Copyright (c) 2001-2020 Mathew A. Nelson and Robocode contributors
 * All rights reserved. This program and the accompanying materials
 * are made available under the terms of the Eclipse Public License v1.0
 * which accompanies this distribution, and is available at
 * https://robocode.sourceforge.io/license/epl-v10.html
 */

using System;
using System.Drawing;
using System.IO;
using System.Reflection;
using net.sf.robocode.dotnet.host.proxies;
using net.sf.robocode.dotnet.host.security;
using NUnit.Framework;

namespace net.sf.robocode.dotnet
{
    [TestFixture]
    public class SimpleTest : TestBase
    {
        [Test]
        public void Graphics()
        {
            var sg = new GraphicsProxy();
            sg.setPaintingEnabled(true);
           /*sg.DrawArc(Pens.Red, new RectangleF(0,0,80,80),-30,10);

            GraphicsPath path = new GraphicsPath();
            path.AddLine(99,98,78,3);
            sg.DrawPath(Pens.Blue, path);
            sg.DrawRectangle(Pens.Yellow, 20,20,30,50);

            sg.DrawLine(Pens.Black, 99, 3, 78, 3);
            sg.DrawRectangle(Pens.Black, 90, 20, 30, 50);

            Brush brush = new HatchBrush(HatchStyle.Vertical, Color.Cyan);
            sg.FillRectangle(brush, new RectangleF(20, 70,


              dataFile.Position = 97;
                dataFile.WriteByte(0xFF);
                dataFile.Write(new byte[] {0xFF, 0xFF, 0xFF}, 0, 3);
            }
        }

        [Test]
        public void StreamOk()
        {
            string tempDir = Path.Combine(Path.GetTempPath(), Path.GetRandomFileName());
           balance due Compass on that date. In January 1996, Builder's Supply sued the Pooles to enforce its lien. The Pooles defaulted on their debt to Compass, and the mortgages became subject to foreclosure.
Ala.Code 1975, § 35-11-211(a), states that a materialman's lien "shall have priority over all other liens, mortgages or incumbrances created subsequent to the commencement of work on the building or improvement" and that "all liens, mortgages and incumbrances... created prior to the commencement of such work shall have priority over all liens for such work." Our supreme court has interpreted this section as follows:
"The date of the recording of a mortgage and the date of the furnishing of materials by the materialman control in determining the priority between the mortgage and the materialman's lien."
Metro Bank v.


with similar fat mass, indicating other possible factors for its determination \[[@B21],[@B22]\]. Leptin may be a marker of risk of CHD, at least in males, and contributes to the CHD risk profile in subjects with insulin resistance \[[@B23]\]. Not much information is available on leptin concentrations in individuals with IGT and to our knowledge there has been no study of leptin in pre-diabetics within the region.

This study aims to determine and compare the serum leptin concentrations of diabetic and non-diabetic patients with those in patients who have pre-diabetes and to correlate it with anthropometric measures of obesity.

Methods
=======

Subjects
--------

In the present study, subjects were selected from the roster of adult, ambulant, non-pregnant patients attending the Diabetes Center at the King Abdulaziz University Hospital in Riyadh, Saudi Arabia. Ethical approval was50.1(11.6)            54.5(10.7)^**f**^
  Systolic blood pressure (mm Hg)    123.1(16.9)      132.8(25.1)^**a**^    130.7(17.5)
  Diastolic blood pressure (mm Hg)   79.9(9.1)        85.1(11.4)            82.9(10.5)
  BMI (Kg/m^2^)                      29.2(7.3)        28.5(4.3)             27.3(4.1)
  Waist (cm)


         0.9(0.3)
  APO A2 mg/dL                       0.4(0.1)         0.4(0.1)              0.3(0.1)
  HOMA-IR \*                         3.3(0.3--23.8)   3.5(0.5--10.2)        9.6(1.1--49.7)^**e**^

Data are presented as means (SD) or as medians (interquartile range) for insulin, leptin and HOMA-IR data. The P-values shown are comparisons of metabolic characteristics for case control versus either    0.4(0.1)                  0.4(0.2)
  HOMA IR \*                         3.1(0.3--12.5)     3.6(1.5--7.3)             7.8(0.6--28.4)^**b**^

\*Data are presented as means (SD) or as medians (interquartile range) for insulin, leptin and HOMA-IR data. The P-values shown are comparisons of metabolic characteristics for case control versus either prediabetics or patients with T2DM: a) 0.046; b) p = 0.03; c) p = 0.004; d) p \< 0.001

Serum leptin was significantly higher in the men with diabetes than


in their non-diabetic counterparts (12.4 \[3.2--72\]; p = 0.0001). In the female patients, serum leptin was higher in those with pre-diabetes (14.09 \[2.8--44.4\]) than in the controls.

Stepwise linear regression analysis revealed a positive correlation between log leptin and hip circumference and BMI (R = 0.31, p = 0.002; R = 0.26, p = 0.006 respectively). Even after adjustment for BMI, there was a positive association between log leptin and hip circumference with an R^2^= 0.086 and p value of 0.006 (see Figure [1](#F1){ref-type="fig"}). The rest of the findings were non-contributory.

![**Log leptin (ng/ml) vs. Hip circumference (cm)**. The correlation of log leptin (ng/mL) with hip circumference (cm) using univariate analysis across all Saudi subjects, case controls, T2DM and pre-diabetic subjects. Blue denotes the actual values with the line ofThe mower and implement will be raised and lowered in unison which often is not desired. In many instances, it is desirable to retain the mower deck in an uppermost or transport position while using a piece of equipment of the 3-point hitch.
In order to alleviate this condition, it is typical to move the connecting cable or linkages outboard of the tractor housing or frame so that access can be made to the linkage or cable for purposes of locking the mower in its uppermost position. The appearance of a utility tractor affects the sales potential of the tractor, i.e., a clean-looking, uncluttered tractor has more sales appeal than one that has exposed cables and linkages. Also, it is desired to cover the cable and linkages so as


born in June
2000 and had been a ward of the juvenile court since 2016, committed two separate first
degree burglaries (Pen. Code, § 460, subd. (a)), one in January 2018 and the other in
April 2018.
       A.     Motion to transfer
       On the basis of the April and June 2018 wardship petitions, the district attorney
moved to transfer R.E. to adult criminal court. (§ 707, subd. (a); see also Cal. Rules of
Court, rule 5.766(a).)
              1.      Probation officer’s report
       In July 2018, the probation officer prepared her report for the transfer hearing,
recommending that      R.E. argues the juvenile court erred in granting the motion to transfer because it
did, in fact, have the authority under the relevant statutes to order his confinement in the
county jail were he to violate his juvenile probation after he turned 19. We agree.
       A.     Standard of review and relevant statutes
       “ ‘Issues of statutory interpretation are questions of law subject to de novo
review.’ ” (People v. Martinez (2016) 5 Cal.App.5th 234, 240.) In interpreting a statute,
       6
         In analyzing the five transfer criteria set forth in section 707, subdivision (a), the
juvenile court


Current Playlist “Feed 4: The Corporation”

Instagram

Archive

Category: Music

This was me two weeks ago, playing a heist in GTA5 online. The FIRST heist. Shhhh. My team pretended they weren't super pissed. They were.

I turned 40 recently. F-O-R-T-Y.

And you know, part of me wants to hide it. To leave everyone who doesn’t know me in real life kind of guessing. Like, “How old is that chick who wrote that book with a bad ass heroine who seriously kicks ass?” So that they’ll think I’m younger and much cooler and well, wait. I am cool. Heh heh.

Yeah.

Come on. YOUTH does not equal cool. OK. So if you are a young person, like say younger than 30, let me just give you a bit of advice (I know you want it!) . .thing out of nowhere (sort of): I have a lot of friends who’ve died. And I still remember them like they’re alive.

So what I want to do is make a list of the friends I’ve lost. I know I’ve forgotten some of the people, which is kind of sucky of me. But as I get closer to my own old age, creeping closer to me like the River Lethe, that is my excuse: old age. Forgetfulness.

Christie B. How we met: 3rd grade. She was funny and interesting and I was jealous of her for being one of two children. Just the other day I remembered how, during college, she used to take a jar of pennies to the airport (pre-9/11) and fake-trip down the walkway and “spill” her


it’s even more clear from the radio-friendly lineup of tracks that made the final cut after months generating material in his new hometown of L.A. This, coupled with the sudden move away from heavyweight independent label 4AD to media-giant Warner Bros., tells us that if Lewis wants to make pop music, he’ll make pop music, pigeon-holes be damned. {Read More on Treblezine…}

If any question loomed about the overall direction Purity Ring would go on their sophomore release, it gets answered pretty quickly on “Heartsigh,” the opener onAnother Eternity. It’s bolder, brighter and beefier than anything on 2012′s Shrines, and Megan James and Corin Roddick’s playful, often introspective electro-pop has transitioned into a vast, aural landscape that manages to be upbeat and energetic, more fun than ominous. The sortof quiet, somber musical channels that were explored onShrines in tracks like “Obedear” and “Shuck” are missing. And the eerie, sometimes uncomfortable wordplay that has been a staple of James’ lyrical ventures are either more sanitized or simply gone in favor of less complex, more digestible bits. {Read more on Treblezine…}

Father John Misty is at his best when juxtaposing irreverent lyrics with the sublime beauty of a slow ’60s jam or a sunny, upbeat number, both found on his sophomore album, I Love You Honeybear. Gorgeous, swirling melodies and horn-infused tracks are jarring in their not-so-subtle, oft ribald subject matters. But this is nothing new for Tillman, who slipped under the Father John Misty moniker after he left Fleet Foxes. When Josh Tillman speaks about his art and


I know that sounds like a lot of ground to cover, but since
oblivion skyrim's gonna have a great engine. Maybe they can make a
ultra large world like that. Anyway, as a Louisiana Native, I know
one thing about this place ; Major Target + Already Enough
Dangerous Wildlife = Death everywhere. Anyway, despite my state
being maybe one of the most rural states. (About 75 % is made
of forest, farmland, swamps, and other such areas, while only
25 % of the state has either small towns or Urbanization or
Large Cities going on)Despite this, we would be a MUST HIT target.
We IRL make up about 45 % of the US Economy (surpirisng this
state ain't in better shape given that) we also have enough oil, to
rival Texas, as well as factories, ports, and such.Tuesday, November 29, 2016

I have been away from computers and
newspapers for a week, far from the madding crowd, celebrating the Thanksgiving
holiday with my family in a mountain cabin.
I was therefore saddened to learn on my return home when I read the
Sunday Los Angeles Times that one of
my very favorite short story writers, William Trevor, had died on Nov. 20, at
the age of 88.

Author Scott Bradfield wrote a perceptive
tribute to Trevor for the LA Times, noting
quite rightly that Trevor's temperament was better suited to the short story
than to the novel, quoting Trevor's remark, "I'm a short story writer,
really, who happens to write novels. Not the other way around."

Bradfield says that for Trevor each short
story is an experiment in form, and requires far more concentration than any
"shaggy, Pulitzer-worthy novel; this


like a traditional Irish
emigration story. The young man goes to
America to get work, while the young woman waits for him to send for her. As usual, work is hard to find, communication
is difficult, and it seems the man has forgotten. But it’s not that conventional. She begins to realizes that what held them
together was not love, whatever that is, but the shared goal of going to
America.

In “Sitting with the Dead,” a woman whose
cold and uncaring husband has just died, must entertain two professional
comforters, to whom she spills her secret hatred for the man. But, it is not that straightforward, and they
know that the dead they have been sitting with is she.

In “Sacred Statues,” a woman whose husband
has some artistic talent but must get by as a simple laborerscullery maid’s romantic memory of distant
music.

In Trevor’s stories, what deeply matters
cannot be openly articulated. In “Traditions,” a long standing secret at a
boy’s school is fueled by mutual fantasy.
In “An Evening Out,” a couple on an arranged date fulfills each other’s
needs in sly, unsavory ways. In
“Solitude,” a secret not meant to be seen and a tragedy not meant to take place
haunts a woman all her life in Ancient Mariner fashion.

These are luminous, restrained stories. Every one of them deserves to be read and
reread, their motivations marveled at, their sentences savored. They fill the reader with awe at the
complexity of the human experience and the genius of William Trevor.

Reality of Artifice

New Short Story Theories

Followers

About Me

Born and raised in the mountains of Eastern Kentucky. Received B.A. from Morehead State University in


 N7      1.2368 (9)     0.0517 (10)     0.5138 (6)     0.085 (3)
  N8      1.1032 (9)     −0.0762 (10)    0.4868 (6)     0.073 (3)
  H8      1.0276         −0.0868         0.4566         0.088\*
  N9look at the Worlds. I'm not thinking about which one I'll do. This is great preparation for those races, and if I think too much about the Worlds then it's a lack of respect for this race.

"It's got all sorts of terrain - sprints, climbs, everything - which is really good for me [in terms of training]. Let's just enjoy this race for now."


and the similarly bright but more diffuse W51 IRS2 region [@Mehringer1994a]. Early follow-up of these regions showed signs of infalling gas and ongoing accretion onto the regions [@Zhang1997a; @Young1998a; @Keto2008b], though later higher-resolution observations revealed that the infall is likely onto molecular cores adjacent to the regions [@Shi2010a; @Shi2010b; @Goddi2015a; @Goddi2016a].

The W51A complex is rich in molecular masers. All three of the high-mass protostars, W51e2, W51e8, and W51 North contain the usual OH [@Etoka2012a], H$_2$O [@Genzel1981a; @Imai2002a; @Eisner2002a], and masers [@Phillips2005a; @Etoka2012a]. However, W51 North also contains some rare or unique masers: SiO [@Morita1992a; @Eisner2002a] and NH$_3$ [@Brown1991a; @Gaume1993a; @Henkel2013a]. Both of these classes of masers are only detected toward a few star forming regions in the Galaxy, with 5-8 known in SiO [@Morita1992a; @Zapata2009c; @Ginsburg2015b; @Cordiner2016a], andlay along a common molecular ridge and are very likely to be within $<1$ pc of each other [@Ginsburg2017a].

Peculiar and notable objects within W51:\
W51 IRS 2
-----------------------------------------

W51 IRS2 is the northern of the two major protoclusters in W51. It is powered by at least one O3/O4 star [@Barbosa2008a] and contains a luminous compact region (Figure \[fig:irs2\]).

### W51 North {#sec:north}

The W51 North hot core is directly adjacent to the W51 IRS2 region and is at least partly embedded within it. This core contains one of the rare SiO masers, so far detected toward only a handful ($\lesssim8$) high-mass star-forming regions [@Eisner2002a; @Zapata2009c; @Ginsburg2015b]. It is one of only a small number [$\lesssim4$ @Walsh2007a; @Hoffman2011b; @Hoffman2011a] of known metastable and non-metastable maser sources [@Madden1986a; @Mauersberger1987a; @Wilson1988a; @Wilson1990a; @Gaume1993a; @Henkel2013a; @Goddi2015a]. It


ionized gas emission [@Lacy2007a], with the molecular counterpart detected only with ALMA observations a few years later [@Ginsburg2017a]. Despite its symmetry, which clearly pinpoints an origin position, no obvious centimeter or millimeter line or continuum source has been detected at the base of the outflow; there is a source very near the base, but offset by at least a few hundred AU.

Peculiar and notable objects within W51: Others
-----------------------------------------------

### OMN2000 LS1

There is a P Cygni supergiant (an evolved high-mass star that may be a Luminous Blue Variable, though no eruptive outbursts have been detected) in the W51 complex, whose presence indicates that high-mass star formation has been ongoing for $>10$ Myr in the cloud [@Clark2009a]. The lack of other evolved massive stars of a similar age suggests that starnot only being forward the point of strengths, but also the points of weakness so that the candidate can work and improve of them.

There could be questions that can have multiple correct answers. So it becomes important to design a technique to analyse such answers well and bring out the right imperative.

It is always a good idea to sample test the leadership questionnaire on a set of people before administering it to a wide variety of audience.


nil {
		return "nil"
	}
	s := make([]string, 0, 6)
	s = append(s, "&alerts.TemplateDesc{")
	s = append(s, "Filename: "+fmt.Sprintf("%#v", this.Filename)+",\n")
	s = append(s, "Body: "+fmt.Sprintf("%#v", this.Body)+",\n")
	s = append(s, "}")
	return strings.Join(s, "")
}
func valueToGoStringAlerts(v interface{}, typ string) string {
	rv := reflect.ValueOf(v)
	if rv.IsNil() {
		return "nil"
	}
	pv := reflect.Indirect(rv).Interface()
	return fmt.Sprintf("func(v %v) *%v { return &v } ( %#v )", typ, typ, pv)
}
func (m *AlertConfigDesc) Marshal() (dAtA []byte, err error) {
	size := m.Size()
	dAtA = make([]byte, size)
	n, err := m.MarshalToSizedBuffer(dAtA[:size])
	if err != nil {
		return nil, err
	}
	return dAtA[:n], nil
}

func (m *AlertConfigDesc) MarshalTo(dAtA []byte) (int, error) {
	size := m.Size()
	return m.MarshalToSizedBuffer(dAtA[:size])
}

func (m *AlertConfigDesc) MarshalToSizedBuffer(dAtA []byte) (int, error) {
	i := len(dAtA)
	_ = i
	var l int
	_ = l
	if len(m.Templates) > 0 {
		for iNdEx := len(m.Templates) - 1; iNdEx >= 0; iNdEx-- {
			{
				size, err := m.Templates[iNdEx].MarshalToSizedBuffer(dAtA[:i])
				if err != nil {
					return 0, err
				}
				i -= size
				i = encodeVarintAlerts(dAtA, i,!= nil {
				return err
			}
			if skippy < 0 {
				return ErrInvalidLengthAlerts
			}
			if (iNdEx + skippy) < 0 {
				return ErrInvalidLengthAlerts
			}
			if (iNdEx + skippy) > l {
				return io.ErrUnexpectedEOF
			}
			iNdEx += skippy
		}
	}

	if iNdEx > l {
		return io.ErrUnexpectedEOF
	}
	return nil
}
func skipAlerts(dAtA []byte) (n int, err error) {
	l := len(dAtA)
	iNdEx := 0
	for iNdEx < l {
		var wire uint64
		for shift := uint(0); ; shift += 7 {
			if shift >= 64 {
				return 0, ErrIntOverflowAlerts
			}
			if iNdEx >= l {
				return 0, io.ErrUnexpectedEOF
			}
			b := dAtA[iNdEx]
			iNdEx++
			wire |= (uint64(b) & 0x7F) << shift
			if b < 0x80 {
				break
			}
		}
		wireType := int(wire & 0x7)
		switch wireType {
		case 0:
			for shift := uint(0); ; shift += 7 {
				if shift >= 64 {
					return 0, ErrIntOverflowAlerts
				}
				if iNdEx >= l {
					return 0, io.ErrUnexpectedEOF
				}
				iNdEx++
				if dAtA[iNdEx-1] < 0x80 {
					break
				}
			}
			return iNdEx, nil
		case 1:
			iNdEx += 8
			return iNdEx, nil
		case 2:
			var length int
			for shift := uint(0); ; shift += 7


{
				if shift >= 64 {
					return 0, ErrIntOverflowAlerts
				}
				if iNdEx >= l {
					return 0, io.ErrUnexpectedEOF
				}
				b := dAtA[iNdEx]
				iNdEx++
				length |= (int(b) & 0x7F) << shift
				if b < 0x80 {
					break
				}
			}
			if length < 0 {
				return 0, ErrInvalidLengthAlerts
			}
			iNdEx += length
			if iNdEx < 0 {
				return 0, ErrInvalidLengthAlerts
			}
			return iNdEx, nil
		case 3:
			for {
				var innerWire uint64
				var start int = iNdEx
				for shift := uint(0); ; shift += 7 {
					if shift >= 64 {
						return 0, ErrIntOverflowAlerts
					}
					if iNdEx >= l {
						return 0, io.ErrUnexpectedEOF
					}
					b := dAtA[iNdEx]
					iNdEx++
					innerWire |= (uint64(b) & 0x7F) << shift
					if b < 0x80 {
						break
					}
				}
				innerWireType := int(innerWire & 0x7)
				if innerWireType == 4 {
					break
				}
				next, err := skipAlerts(dAtA[start:])
				if err != nil {
					return 0, err
				}
				iNdEx = start + next
				if iNdEx < 0 {
					return 0, ErrInvalidLengthAlerts
				}
			}
			return iNdEx, nil
		case 4:
			return iNdEx, nil
		case 5:
			iNdEx += 4
			return iNdEx, nil
		default:
			return 0, fmt.Errorf("proto: illegal wireType %d", wireType)
		}
	}
	panic("unreachable")
}

var (
	ErrInvalidLengthAlerts = fmt.Errorf("proto: negativebuceando con mis gafas. Hacía frío allí al fondo, en esas vastas salas subacuáticas. Las algas se agitaban, los peces se deslizaban a mi lado lentamente y en silencio. Cuevas rocosas tachonadas de erizos de mar y anémonas rojas, campos de arenas onduladas como dunas saharianas. Un mundo feliz. En completo silencio sobrevolaba prados y precipicios poseído por una felicidad inefable, aterrizando de vez en cuando sobre islas de coral, saludando con la mano a los peces, sumergiéndome en busca de cangrejos ermitaños ocultos en sus conchas. Sentí un extraño deseo de tumbarme en el lecho del mar, relajado como un muerto. Pero el muerto es él, no yo.

¿Hasta dónde he llegado con su retrato, con el monumento que quise erigir en su memoria? ¿Qué he dicho? ¿A


eres bastante fuerte, la verdad. Pero el hecho de que uno tenga que desaparecer... a veces me veo a mí misma en un rápido proceso de descomposición. —Y acompaña esas palabras con una sonrisa complaciente, como una abuela contando una fábula antigua, una historia llena de sabiduría—. Me voy encogiendo, me convierto en polvo, el cabello me cae a través de las mandíbulas, y mientras me desplomo, los pensamientos se me escapan del cuerpo como el aire de un neumático pinchado... Aunque no es del todo así, no del todo.

North alza su mirada despacio hacia el centro de los cristales dobles de sus gafas e interviene:

— _Mach ksach rrapher zoch zamen..._ ¿No podríais comunicaros en una lengua más civilizada que ese patético dialecto germano...?

Y con la misma inefablepalabra misión, _queeste_ , con una larga ese y, riéndose, dice:

—Un sueño mío de toda la vida es viajar al centro de España, una zona blanca y totalmente vacía en el mapa, y quedarme ahí. —Y en voz baja, casi riendo, añade—: Para sufrir.

La chica abre la boca para decir algo pero se contiene. Da media vuelta y sube la colina, jadeando ligeramente. Él sabe que ella actúa así para disimular el disgusto que le han producido sus palabras y también eso le hace reír, aunque con menos convicción. Y sin embargo, en el espejo que se ha puesto delante de sí mismo, sus palabras no son insignificantes: las facciones de un rostro que recuerdan al de San Juan de la Cruz, acentuadas por el paisaje desolado que


una lección a esos herejes. Ha llegado al fin la fase _del castigo_ )

y eso la acongoja. Y con la congoja viene, como siempre, el desprecio. Pero esta vez Clara no le rechaza, sino que tira de él. Salen del cuarto de baño y entran en la habitación donde está la cama. Es allí adonde ella quiere llevarle. Y de pronto André se percata de que debe hacer lo que quería hacer. Debe dar cuerda al consuelo que deseaba, como si fuera una vieja máquina. Crac, crac, cruje la cama cuando se tumba sobre ella, ya sin sostener a Clara, sin sujetarla. Permanece tendido, observando las vigas vivas del techo, y sabe que eso es lo más terrible que ella ha podido hacerle. Eso sí que es unme queda más que angustia y malestar, incluso odio tal vez. Aunque escribiera mil veces la palabra FIN a pie de página, el libro no habría concluido. El título es una declaración, no una realidad. Naturalmente que André ha muerto. Pero ese no era el título de su libro. A mí me correspondía acabar con su vida. En lugar de ello, le persigo hasta su hotel, le asesino, cierro de golpe la tapa de su ataúd. He fracasado. No sé quién fue.

Así que, querido amigo, que otro describa tu muerte. Que se lleve lo que quiera de estos papeles. No me molestes más, déjame en paz. Importúnala a «ella» o a tus amigos North y Schramm, o deambula con Cyril en espíritu por esa isla a la que


with a valve 44, which is to relieve the fuel in the drain line 40 to a fuel return line 46.
Lift of the needle valve 31 depends on a kinetic balance among the upward and downward hydraulic forces and the return force. Control current from the control unit 8 energizes a solenoid 45 to open the valve 44 in the drain line 40. Thus, since the fuel flow at the throat 39 is more restricted than at the throat 41, the fuel pressure in the balance chamber 30 drops so that the force to lift the needle valve 31 off the seat overcomes the sum of the depressing force resulting from the fuel pressure in the balance chamber 30 and the resilient force of the return spring 47in the common-rail pressure, which might result from the fuel injection that is carried out along the fuel delivery out of the high-pressure fuel-supply pump, by stopping the high-pressure fuel-supply pump. Rendering the high-pressure fuel-supply pump inoperative when the engine operates actually results in the common-rail pressure going on decreasing. Thus, much variation appears in the common-rail pressure to cause the scattering or variance in amount of fuel injected and combustion every cylinder. If any learning made it possible to monitor the common-rail pressure, the problem raised due to the pulsation of the common-rail pressure would remain unsolved.
Since the high-pressure fuel-supply pump continues to apply the fuel to the common rail even when the pressure detector is checking the amount of pressure drop in the common-rail pressure resulting


the amount of pressure drop in the common-rail pressure.
In another aspect of the present invention, a common-rail fuel-injection system is disclosed, wherein the control unit outputs a command pulse to actuate the injector in accordance with the injection factors, with detecting whether or not the engine operates under a steady states, and acquires a correlative data between the command pulse and the amount of fuel injected through a learning process that is executed, when the engine operates under steady condition, as to the command pulse output and the actual amount of fuel injected, which is found based on the amount of pressure drop in the common-rail pressure resulting from the fuel injection out of the injector actuated with the command pulse. The actual amount of fuel injected oftenamount of fuel reasonable to be injected actually may be derived from the deviation in pressure on the basis of an injection map, which has been previously prepared. Thus, the actual amount of fuel injected is feedback controlled to come in matching with the desired amount of fuel to be injected. Especially, no variance in the amount of fuel injected every cylinder occurs in even when the engine is running at low-speed revolutions such as idling, thereby reducing uncomfortable vibration and noise, fuel consumption of the engine and further improving the exhaust-control performance. In addition, when the feedback control of the amount of fuel injected is troublesome because the fuel injected is minute in quantity as in the fuel injection under idling of engine or in the pilot


of a vortex phase mask with complex transmittance $\exp(\pm i\theta)$. This calculation accounts for diffractive losses owing to the phase mask and Lyot stop as well as the SMF coupling efficiency. With the star centered on the optical axis, light from point sources in an annular region around the star will transmit into the spectrograph. The inset shows the 2D throughput map for planets in a 4$\times$4 $\lambda/D$ field of view. The throughput only changes by 1-2% for a range of possible telescope apertures.[]{data-label="fig:thpt"}]({etap_2.5_v2}.pdf){width="0.9\linewidth"}

![image](etap_jitter_N2048_Ntrials50_ensemble.pdf){width="0.325\linewidth"} ![image](etas_jitter_N2048_Ntrials50_ensemble.pdf){width="0.325\linewidth"} ![image](tau_jitter_N2048_Ntrials50_ensemble.pdf){width="0.325\linewidth"}

Theoretical performance
=======================

In this section, we predict the performance of VFN in realistic noise environments. We write the signal from the planet and star that enters the spectrograph as $S_p = \eta_p \Phi_p \tau \Delta\lambda A q T$ and $S_s = \eta_s \Phi_s \tau \Delta\lambdaof the star. We treat the star as a ensemble of incoherent point sources in a uniform disk. For unresolved sources, $\eta_s$ may be approximated as variance of the source distribution in units of $\lambda/D$ [@Ruane2016dissertation]: $$\eta_s = \left(\frac{\Theta}{\sqrt{12}}\frac{D}{\lambda}\right)^2,$$ where $\Theta$ is the angular diameter of the source. The minimum possible integration time is therefore $$\tau_\Theta = \left(\frac{\Theta}{\sqrt{12}}\frac{D}{\lambda}\right)^2\frac{\tau_0}{\eta_p^2}.$$ More generally, $\eta_s$ may be approximated by summing the variances of the source and jitter distributions.

Low-order aberrations in the Zernike basis
------------------------------------------

![image](ZmodesFig.pdf){width="0.75\linewidth"}

A major benefit of VFN is that it does not rely on high-precision control of all low-order aberrations. Although an overall rms wavefront error of $\omega<1/10$ waves is desired for optimal planet light coupling, the nulling of the star is unaffected by Zernike aberrations, $Z_n^m(r,\theta)$, if $|m| \ne 1$. To


a CCF SNR of 5 in $J$ band is 0.06, whereas 0.11-0.16 is required in the remaining bands. The actual values are listed in Table \[tab:tau\_Ross128b\_finiteStar\].[]{data-label="fig:SNRgain"}](SNRgainsRoss128b_loglog.pdf){width="0.85\linewidth"}

We calculate the distribution of peak values of the resulting CCFs as a function of the SNR per spectral channel for 100 observations in a set of wavelength ranges that correspond to $r$, $J$, $H$, $K$, and $L^\prime$ bands (see Table \[tab:finitestars\]). In practice, the number of pixels in the spectrograph or atmospheric dispersion will likely limit the maximum spectral bandwidth. Assuming that stellar photon noise is the dominant noise source and that the planet spectrum is known, Figure \[fig:SNRgain\] shows the resulting CCF SNR, defined as the ratio between the median of the peak values and the standard deviation of the distribution ofshows an estimate of the integration time for achieving a CCF SNR of 5 as function of rms tip-tilt jitter, assuming coma aberrations are controlled to 5 nm rms with Keck AO or an upgraded version thereof. The remaining assumptions are listed in Table \[tab:simparams\]. Controlling tip-tilt to $10^{-2}$ $\lambda/D$ rms and coma to 5 nm rms yields an integration time of $\sim$400 hr.

Current state-of-the-art AO systems [e.g. SCExAO; @Jovanovic2015] are capable of controlling tip-tilt errors to $\sim10^{-2}$ $\lambda/D$ rms and low-order Zernike modes to $\sim$50 nm rms [@Singh2015]. Although the wavefront error requirements shown in Fig. \[fig:tau\_vs\_tt\_Ross128b\] are 10$\times$ smaller than currently achieved on SCExAO, improved correction is expected with closed-loop predictive control. @Males2018 recently showed that starlight suppression may be improved by a factor of 1400$\times$ for high-contrast imaging with a coronagraph and a bright guide star, which


spectrograph. Combined with the template-matching technique at high spectral resolution, VFN provides a pathway to characterize Earth-sized planets in the habitable zone of nearby M dwarfs, such as Ross 128 b, in $\sim$400, $\sim$100, and $\sim$30 hr with Keck, TMT, and LUVOIR, respectively. The integration time is strongly dependent on the planet properties as well as tip-tilt and coma aberrations but is otherwise insensitive to wavefront errors. VFN requires wavefront residuals of $\sim10^{-2}$ $\lambda/D$ rms of tip-tilt and on the order of a few nm rms of coma. The finite size of the star dominates the stellar photon noise budget in the case for ultra-stable space telescopes designed for exoplanet imaging, such as LUVOIR. VFN enables efficient, targeted characterization of known planets orbiting nearby stars. A laboratory demonstration of the VFN technique is underwaydifferent Ang paralogs genes have been so far described (mAng1 to mAng6), all resulting from tandem duplications of the hAng ortholog (mAng1). Only four out of the six copies (mAng1 to mAng4) have been tested for activity. Among these, mAng1, mAng3 and mAng4 present a ribonuclolytic and angiogenic activity (Nobile *et al*., 1996; Fu *et al*., 1999; Crabtree *et al*., 2007a).

Sites involved in Ang activity have been identified through comparative structural analyses and functional data \[[@B31]-[@B33]\]. Moreover, mAng2 has been reported to lack angiogenic activity and has been considered to be a pseudo-gene \[[@B31]\]. To date, no function has been reported for either mAng5 or mAng6. Recent studies have provided evidence for the action of diversifying selection post-dating the duplication events that gave rise to five of the