      $order->setSubtotalInvoiced($order->getSubtotalInvoiced() + $this->getSubtotal());
        $order->setBaseSubtotalInvoiced($order->getBaseSubtotalInvoiced() + $this->getBaseSubtotal());

        $order->setTaxInvoiced($order->getTaxInvoiced() + $this->getTaxAmount());
        $order->setBaseTaxInvoiced($order->getBaseTaxInvoiced() + $this->getBaseTaxAmount());

        $order->setHiddenTaxInvoiced($order->getHiddenTaxInvoiced() + $this->getHiddenTaxAmount());
        $order->setBaseHiddenTaxInvoiced($order->getBaseHiddenTaxInvoiced() + $this->getBaseHiddenTaxAmount());

        $order->setShippingTaxInvoiced($order->getShippingTaxInvoiced() + $this->getShippingTaxAmount());
        $order->setBaseShippingTaxInvoiced($order->getBaseShippingTaxInvoiced() + $this->getBaseShippingTaxAmount());

        $order->setShippingInvoiced($order->getShippingInvoiced() + $this->getShippingAmount());
        $order->setBaseShippingInvoiced($order->getBaseShippingInvoiced() + $this->getBaseShippingAmount());

        $order->setDiscountInvoiced($order->getDiscountInvoiced() + $this->getDiscountAmount());
        $order->setBaseDiscountInvoiced($order->getBaseDiscountInvoiced() + $this->getBaseDiscountAmount());
        $order->setBaseTotalInvoicedCost($order->getBaseTotalInvoicedCost() +The present invention relates to filling the space underneath a bed and, more particularly, to an inflatable under the bed filler.
Some individuals, especially children, suffer from fear associated with certain open spaces in their sleeping area where it is difficult to observe that they are empty first-hand. These open spaces are generally located in the closet and under the bed in the sleeping area. The open space under the bed is usually present due the bed frame, a structure which establishes the mattress at an acceptable height. The individual in the sleeping area fears that these unobservable areas are occupied by apparitions, monsters or other imaginary entities, which disturbs a restful sleep. Other individuals, usually a parent or guardian, routinely have to intervene and show the affected individual


that these open areas are unoccupied. This is accomplished by opening and illuminating the open spaces to physically establish that the area is unoccupied. Simple, verbal assurances are usually not sufficient; the affected individual must be shown that the area is unoccupied to alleviate the fear. The time to accomplish this further reduces the amount of restful sleep obtained, both for the affected individual and the assisting individual.
As can be seen, there is a need for a device that quickly shows an individual there is nothing harmful underneath a bed.Methods for cultivation of keratinocytes with an air-liquid interface.
In ordinary cultures, cells are grown on artificial substrates and immersed in culture medium. In vivo, interfollicular epidermal cells grow on the basement membrane and are exposed to air. In a first effort to render the culture of these cells more physiological it seems legitimate to raise the cultured cells to the air-medium interface. Epidermal cells can be raised by the use of collagen gels maintained on a rigid support. They can also be grown on nitrocellulose filters coated with collagen or coated with a basement-membrane equivalent (BME) previously deposited by bovine corneal endothelial cells. By raising the cultures to the air-medium interface there is some evidence of a more complete differentiation, as evaluated by morphologic criteria. However, biochemically, the


killings, or son of a bitch, I will swear at you in that forum" REUTERS The most controversial quotes from Rodrigo Duterte On Abu Sayyaf Islamic militants "If I have to face them, you know I can eat humans. I will really open up your body. Just give me vinegar and salt, and I will eat you. If you annoy me to the fullest... I will eat you alive. Raw" EPA

The Philippines is a former U.S. colony that has been a close U.S. partner for decades. Since sweeping to power last spring, Duterte has repeatedly lashed out at his longtime ally, threatening to ditch the United States for China and Russia.

In September, when President Obama raised questions about the bloody anti-drug crusade, Duterte lectured him on colonialism, referringsee them, they’re two different sports. Not like at the 100 meters at the Olympics, not because they’re not running the same speed as the men. It’s just because we play five sets. I’m not saying the men work harder than the women, but if you have to train to play five sets, it’s a longer distance. It’s like someone training to be a 400-meter runner and someone training to be a 600-meter runner. I think the women should play best-of-five sets. I don’t see why they couldn’t do it. It would mean the days in the Slams are a little bit longer. And maybe it doesn’t have to be from the first rounds. I think either the men go three sets or the women go five sets.


     Under RCW 10.14.080, a court shall enter a civil anti-harassment protection order

if it "finds by a preponderance of the evidence that unlawful harassment exists." RCW

10.14.080(3).

       "Unlawful harassment" means a knowing and willful course of conduct
       directed at a specific person which seriously alarms, annoys, harasses, or
       is detrimental to such person, and which serves no legitimate or lawful
       purpose. The course of conduct shall be such as would cause a reasonable
       person to suffer substantial emotional distress, and shall actually cause
       substantial emotional distress to the petitioner.

RCWwas in part initiated, evidenced, or carried out by means of language, either

spoken, written, or printed."' Cox v. Louisiana, 379 U.S. 559, 563, 85 S. Ct. 476, 13 L.

                                             8
No. 33977-7-111
Campbell v. Drollinger

Ed. 2d 487 (1965) (quoting Giboney v. Empire Storage & Ice Co., 336 U.S. 490,502, 69

S. Ct. 684, 93 L. Ed. 834 (1948)).

       Ms. Drollinger next assigns error to three of the trial court's oral findings, arguing

they are not supported by substantial evidence. First, she argues


hemostat clamps. The cells (in the sealed box) were then placed in a 5% CO~2~ incubator and cultured under oxygen-glucose deprivation (OGD) conditions for 1 h to simulate ischemia. To simulate reperfusion, the homemade sealed box was removed from the incubator, and the ischemic solution in the Petri dishes was removed by aspiration. The cells were washed three times with 2 mL of simulated reperfusion solution containing 10% FBS. Subsequently, 2 mL of simulated reperfusion solution was added to the cells to restore the supply of oxygen and glucose, and the cells were cultured for 3 h in an incubator supplemented with 5% CO~2~. After the simulated reperfusion, SAN cells were subjected to patch-clamp experiments.

The cultured SAN cells were divided into five groups. The normal group included SANACG CAC GAT TTC CC-3; HCN4 target gene 74 bp, upstream: 5-GCTGTCCTGTCGTCTTGTTTCTC-3, downstream: 5′-CGGTTATTGTTGGTGGTGTATCTC-3′. Reverse transcription: 42°C water bath for 60 min, and 70°C water bath for 10 min. Next, PCR was conducted with the GeneAmp 5700 fluorescence quantitative PCR instrument using the following cycle parameters: 95.0°C 10 min (one cycle); 95.0°C, 25 s, 55.0°C, 25 s, 72.0°C, 50 s, one cycle; 72.0°C 5 min (one cycle). A computer was connected to the PCR instrument and implemented the reactions according to the above parameters, and each cycle was automatically recorded by the computer in accordance with the fluorescence signal values in the reaction tube, and curved. At the end of the reaction, the results were analyzed, and the fixed values were automatically quantified by machine software. The results


with the astragaloside group, the amplitude of *I*~f~ in the washed group was significantly reduced.

![**(A)** Representative *I*~f~ traces recorded from the different groups. **(B)** The current--voltage (*I--V*) curves of each group. **(C)** The peak current densities in each group exhibited significant differences. *n* = 10, ^![](fphar-09-00551-e001.jpg)^*P* \< 0.01 vs. the normal group. ^∗^*P* \< 0.05 vs. the I/R model group.](fphar-09-00551-g003){#F3}

The *I--V* curve is also shown, and compared with the normal group, under voltages below -70 mV, the decrease in current density in the I/R model group was statistically significant (*P* \< 0.05). However, the shape of the *I--V* curves remained essentially the same. Astragaloside treatment resulted in varying degrees of increased current density under various voltages. Under a voltage range of -70 ∼-170 mV, the recovery of the*I--V* curve was particularly evident. Compared with that of the model group, the difference was statistically significant (*P* \< 0.05) (**Figure [3B](#F3){ref-type="fig"}**). The results showed that after establishing the simulated I/R model, the current density of the *I*~f~ was decreased in the SAN cells under various voltages. The decrease was even more pronounced upon hyperpolarization (below -70 mV). Astragaloside increased the current density of the *I*~f~ in the SAN cells after establishing the model. The increase was especially significant upon hyperpolarization (below -80 mV), and the results indicated that the I/R and astragaloside-induced changes in the current density of the *I*~f~ were voltage dependent.

The peak current density of the *I*~f~ in normal SAN cells and the I/R model group was -43.48 ± 1.08 pA/pF and -19.64 ± 2.14


Expression of HCN4
-----------------------------------------------------

Compared with that of the normal group, the expression of HCN4 was significantly decreased in the model group (*P* \< 0.01). Compared with that of the model group, the expression of HCN4 of the high dose group was significantly increased, and it was clearly greater than that of the medium or low dose group, with a difference that is statistically significant (*P* \< 0.05 or *P* \< 0.01) (**Figure [8](#F8){ref-type="fig"}**).

![**(A)** The effect of astragaloside on the expression of HCN4. **(B)** Quantification of different group on the expression of HCN4 protein. Compared with the Normal group, ^ΔΔ^*p* \< 0.01; compared with the model group, ^∗∗^*p* \< 0.01, ^∗^*p* \< 0.05.](fphar-09-00551-g008){#F8}

Discussion
==========

The main findings of the current study are that (1) astragaloside shortened the APD20 and APD50 in damagedcontent . split ( prefix + "select " ) . pop ( )

entities. forEach ( function ( element ) {

if ( typeof element. sendMessage == "function" && element. name == lookfor ) {

sendError = false

bot. createMessage ( msg. channel . id , String ( element. name + '

Tank: ' + element. label + '

Id: ' + element. id + '

Alpha: ' + element. alpha + '

Color: ' + element. blend . amount + '

Max Health: ' + element. health . max + '

Current Health: ' + element. health . amount + '

Is Invulnerable: ' + element. invuln + '

Score: ' + element. photo . score + '

Level: ' + element. skill . level ) ) ;

}

} )

if ( sendError ) {

bot. createMessage ( msg. channel . id ,


"Was unable to find an entity by that name" ) ;

}

}

if ( msg. content == prefix + 'ping' ) {

bot. createMessage ( msg. channel . id , 'Pong!

' + "

Running on glitch: " + process. env . ISONGLITCH + "

Directory: " + __dirname + "

File name: " + __filename ) ;

}

if ( msg. content . includes ( prefix + 'help' ) ) {

bot. createMessage ( msg. channel . id , '***COMMANDS***

Prefix: ' + prefix + '

(No space after prefix when running command)

**ping** - tells u if the server is running

**kill** *<id>* - Kills a player (Authorization required)

**broadcast** *<message>* - broadcasts a message (Authorization required)

**query** *<internalname>* - returns some data about a tank (must use internal name)

**select** *<name>* - returns some data about in-game users

**players** - list in-game players

**stat**msg. author . id == owner_id ) {

sockets. broadcast ( msg. content . split ( prefix + "broadcast" ) . pop ( ) + " - " + msg. author . username )

bot. createMessage ( msg. channel . id , 'Message Broadcast!' ) ;

} else {

console. log ( "Unauthorized user" , msg. author . username , "tried to broadcast" )

bot. createMessage ( msg. channel . id , unauth ( 2 ) ) ;

}

}

if ( msg. content . startsWith ( prefix + 'query' ) ) {

let output = ''

var query = msg. content . split ( prefix + "query " ) . pop ( )

try {

var botreturn = eval ( 'Class.' + query ) ;

for ( var key in botreturn ) {

if ( output. length > 500 ) {


According to CDMA2000 air interfaces technical specifications, it is necessary for a base station system to transmit overhead messages to a terminal within a coverage area continuously in order to notify the terminal the latest configuration information of the system. Wherein the overhead messages bear the configuration information of the base station system, when the configuration information of the base station system changes, the configuration serial number in the overhead messages will change correspondingly, to notify terminals with changes of the configuration information of the base station system.
According to CDMA2000 protocol, after a terminal receives overhead messages transmitted from the base station system in origination state, paging response state or idle state, the terminal enters into an overhead message update sub-state. Time taken by the terminal in thesystems supported by credit/debit card and calling card applications, modem calling systems are much more complex. By way of example, in modem calling systems there can be applications involving one telephone number with multiple simultaneous inbound calls, multiple xe2x80x9cfollow-mexe2x80x9d calls, or conferencing calls. Moreover, more than two calls may be in progress at the same time. Unfortunately, due to the complexity of modem calling systems, conventional credit/debit card and calling card applications are not capable of performing functions such as coordination of multiple calls or conferences, or insuring that charges incurred do not exceed an available balance in a subscriber""s account.
In light of the foregoing, the invention generally relates to a system for rating and debiting complex debit card calls. The preferred embodiment of the invention estimates the


excitement began when I visited Kasauli, a rural village in North India and taught python to a group of 10 students that were my age.

After the summer I continued to talk to the students through skype lessons once every couple of weeks. Over the course of the 2014-2015 school year, I also began to play around with web programming and websites. I came across a program called Google Coder, which uses the raspberry pi to teach html, css, javascript, and node.js. This led me to develop a second curriculum, centered around web programming and Coder. in the 2015 summer, at the TechShop in Redwood City I built a kid-friendly case for the Coder-Pi and took it with me when I went back to Kasauli, India. This time Iof mutation in a highly interactive set of projects that link researchers at Brandeis University and Tufts University studying three powerful model organisms: the bacterium pound coli, the single cell eukaryote, the budding yeast S. cerevisiae, and the metazoan, fruit fly D. melanogaster. Our goal is to understand in great detail the way several important types of mutations arise and to identify transcription, replication and DNA repair factors whose defects elevate their appearance. Importantly, the proposed core facilities will enable us to expand our studies beyond what has been previously possible and to test our models on genome-wide scales. Through the Core Facilities proposed as an integral part of this Program Project, participants will apply state-of-the-art high-throughput technologies to their studies of repair-associated mutagenesis. Automation of data collection


struggled to make their presence felt. Eyes on next week's derby, perhaps?

Advertisement

"We have to be honest and say it wasn't good enough, but I'm more determined than ever to fix this," said Sydney coach Graham Arnold. "The past month hasn't been good and there's some players who had too many chances. Now it's time for changes.

"Every coach goes through a difficult period and this would be the most difficult period, if I'm honest, that I've ever had in five years in the A-League."

And to cap it off, poor Vedran Janjetovic will bear the blame. This is one moment will be the one he'll never want to see again.

Moving to clutch a relatively simple incoming cross in the 22nd minute, which should have bounced harmlessly into his hands, heBuy WoW Gold, WoW Power leveling Service

Category Archives: LOL

Faint quiet mysterious castle underneath. Ray water flowing out from the rock crevices, suspended the development of a triangular stone and an impressive palace, that was a awfully mysterious. very little broken items of foliage plate filled with branches, the sky just like the Galaxy generally, rather than sinking little planet appears the situation of the moon, however cannot replace the sunshine of the moon, folks appear to feel faint image of the ocean and it appears within the air. Here is Tulu tribe place to measure, they dig the dragon realm as native peoples, living a quiet and peaceful life, rivers and lakes Union and disputes Guards ne’er influenced them.
Verdant mountains seclusion what quite race.The glare of the sun’s


find where to buy the cheapest runescape gold.

Only members, tired of the magic tree cut down?By ivy annoyed?It feels like to hit sawmill sparse inside hua? If this sounds like you, so don’t worry, because there are two branches of new trees the woodcutter most worthy of this month.

Many of you may think you know what this is, some of you have no idea, most of you are wrong anyway. Allow me to explain.
There is a subtle difference between Purchasing Gold directly with Cash and Purchasing a Bond with Cash which is then sold for Gold. Adding that intermediary BOND step means that Gold or items are sourced directly from the existing player economy and user base rather than “being generated out of thin air”. If Jagex soldworse, don't you?" "Oh, good evening, Mr. Carrington." "Good evening, Jeannette." "Where's Mrs. Carrington?" "I'm not sure, but you could try Kristina's room." " Good." "Uh, how is Kristina today?" " Just fine." "Mrs. Curtis organised a little tea party for her this afternoon." "Mrs. Curtis did?" "Mm-hm." "And Kristina had such a time." "Krystle?" "Turn around, let me see how pretty you look." "Oh, you look so pretty." "Oh, that looks so pretty on you." "Come in." "Daddy, Daddy." " Daddy." " There's my girl." " Hello, Blake." " Sarah." "Where's Krystle?" "And, uh, Kristina's nurse?" "Krystle had to go into town for a few minutes." "The nurse is having dinner." "I told her I'd sit in for her." "I see." " Daddy, do you like my


Group I metabotropic glutamate receptors (mGluR1 and mGluR5) (M. E. Fundytus, CNS Drugs 15:29-58 (2001)) and vanilloid receptors (VR1) (V. Di Marzo et al., Current Opinion in Neurobiology 12:372-379 (2002)) to pain processing. Inhibiting mGluR1 or mGluR5 reduces pain, as shown by in vivo treatment with antibodies selective for either mGluR1 or mGluR5, where neuropathic pain in rats was attenuated (M. E. Fundytus et al., NeuroReport 9:731-735 (1998)). It has also been shown that antisense oligonucleotide knockdown of mGluR1 alleviates both neuropathic and inflammatory pain (M. E. Fundytus et al., Brit. J. Pharmacol. 132:354-367 (2001); M. E. Fundytus et al., Pharmacol, Biochem. & Behavior 73:401-410 (2002)). Small molecule antagonists for mGluR5-attenuated pain in in vivo animal models are disclosed in, e.g., K. Walker et al., Neuropharmacol. 40:1-9 (2000)the administration of bismuth compounds such as bismuth subsalicylate and colloidal bismuth citrate. The bismuth compounds are believed to enhance secretion of mucous and HCO3−, inhibit pepsin activity, and act as an antibacterial against H. pylori. Ingestion of bismuth compounds, however, can lead to elevated plasma concentrations of Bi+3 and can interfere with the absorption of other drugs.
Prostaglandin analogues, such as misoprostal, inhibit secretion of acid and stimulate the secretion of mucous and bicarbonate and are also used to treat ulcers, especially ulcers in patients who require nonsteroidal anti-inflammatory drugs. Effective oral doses of prostaglandin analogues, however, can cause diarrhea and abdominal cramping. In addition, some prostaglandin analogues are abortifacients.
Carbenoxolone, a mineral corticoid, can also be used to treat ulcers. Carbenoxolone appears to alter the composition and quantity


disease is associated with other disorders such as gallstones, inadequate absorption of nutrients, amyloidosis, arthritis, episcleritis, aphthous stomatitis, erythema nodosum, pyoderma gangrenosum, ankylosing spondylitis, sacroilitis, uveitis, and primary sclerosing cholangitis. There is no known cure for Crohn's disease.
Cramps and diarrhea, side effects associated with Crohn's disease, can be relieved by anticholinergic drugs, diphenoxylate, loperamide, deodorized opium tincture, or codeine. Generally, the drug is taken orally before a meal.
Broad-spectrum antibiotics are often administered to treat the symptoms of Crohn's disease. The antibiotic metronidazole is often administered when the disease affects the large intestine or causes abscesses and fistulas around the anus. Long-term use of metronidazole, however, can damage nerves, resulting in pins-and-needles sensations in the arms and legs. Sulfasalazine and chemically related drugs can suppress mild inflammation, especially into recognize parts of the body, unusual movements, loss of bladder control, imbalance, and falling, and fainting. The symptoms can be permanent and can be associated with coma or stupor. Examples of drugs for treating strokes include anticoagulants such as heparin, drugs that break up clots such as streptokinase or tissue plasminogen activator, and drugs that reduce swelling such as mannitol or corticosteroids. The Merck Manual of Medical Information 352-355 (R. Berkow ed., 1997).
Pruritus is an unpleasant sensation that prompts scratching. Conventionally, pruritus is treated by phototherapy with ultraviolet B or PUVA or with therapeutic agents such as naltrexone, nalmefene, danazol, tricyclics, and antidepressants.
Selective antagonists of the metabotropic glutamate receptor 5 (“mGluR5”) have been shown to exert analgesic activity in in vivo animal models (K. Walker et al.,


Approved and experimental countermeasures against pestiviral diseases: Bovine viral diarrhea, classical swine fever and border disease.
The pestiviruses, bovine viral diarrhea virus (BVDV), classical swine fever (CSFV) and border disease virus, are important livestock pathogens in many countries, but current vaccines do not completely prevent the spread of infection. Control of pestiviral diseases is especially difficult due to the constant viremia and viral shedding of persistently infected (PI) animals, which must be identified and eliminated to prevent disease transmission. Existing vaccines are limited by the delay between vaccination and the onset of protection, the difficulty of differentiating serologically between vaccinated and naturally infected animals and the need for broad vaccine cross-protection against diverse virus strains. Antiviral therapy could potentially supplement vaccination by providing immediate protection in the case ofby conventional impregnating processes is obtained by spray drying, meanwhile, larger amount of titanium and no agglomerates are obtained. But the catalyst particles produced by spray drying process must be collected in a mineral oil, therefore, equipment cost for catalyst production is increased and production operation is more difficult. U.S. Pat. No. 6,303,716 discloses a process for preparing a high-activity solid catalyst for producing all-density polyethylene by gas phase polymerization. Said process comprises the step of: using powdered magnesium as raw material to form a magnesium halide in nascent state; reacting the magnesium halide in nascent state with titanium tetrachloride, diethyl aluminum chloride in the presence of tetrahydrofuran to form a complex; supporting the complex onto silica carrier; and heating and drying the silica carrier loading said complex


   static thread_detail::uintmax_atomic_t const uninitialized_flag=BOOST_ONCE_INITIAL_FLAG_VALUE;
    static thread_detail::uintmax_atomic_t const being_initialized=uninitialized_flag+1;
    thread_detail::uintmax_atomic_t const epoch=flag.epoch;
    thread_detail::uintmax_atomic_t& this_thread_epoch=thread_detail::get_once_per_thread_epoch();

    if(epoch<this_thread_epoch)
    {
        pthread::pthread_mutex_scoped_lock lk(&thread_detail::once_epoch_mutex);

        while(flag.epoch<=being_initialized)
        {
            if(flag.epoch==uninitialized_flag)
            {
                flag.epoch=being_initialized;
                BOOST_TRY
               {
                    pthread::pthread_mutex_scoped_unlock relocker(&thread_detail::once_epoch_mutex);
                    BOOST_THREAD_INVOKE_RET_VOID(f,p1, p2, p3) BOOST_THREAD_INVOKE_RET_VOID_CALL;
        }
                BOOST_CATCH (...)
                {
                    flag.epoch=uninitialized_flag;
                    BOOST_VERIFY(!pthread_cond_broadcast(&thread_detail::once_epoch_cv));


not healthy for your pocket. Well, it is not true at certain points! Although it’s a fact that the installation might cost you a bit, it is going to be much cheaper in the long run because you will not paying much for the monthly dues. In addition to that, maintenance is simply all about keeping it tidy and service and/or product warranties are usually covered by the company. If you are still in doubt, then refer to other reputable sites on the web.

Somehow a new tech which is into further development.
If you are person who loves new things, electricity generated through a solar technology might fit your taste. But not only that, companies do not end the technology here but rather continued to research and make further[Effects of recombinant adeno-virus vector carrying interleukin-5 antisense on the expression of interleukin-5 mRNA and protein in CD4+ T lymphocytes of asthmatic rats].
To construct recombinant adeno-associated virus vector carrying antisense interleukin-5 (IL-5) gene (rAAV-asIL-5), and to explore the effects of this virus transfection on IL-5 mRNA and protein in CD(4)(+) T lymphocytes of asthmatic rats. The eukaryotic antisense IL-5 expressing vector plasmid of recombinant adeno-associated virus (pasIL-5/rAAV) was constructed by gene recombination technique. The rAAV-asIL-5 particles were produced by co-transfection of pasIL-5/rAAV, pXX2, and pXX6 in package cell 293 through phosphate calcium deposit, and the titers of rAAV-asIL-5 were measured by Southern blot. The rAAV-asIL-5 particles were transfected into CD(4)(+) T lymphocytes obtained by gradient of Ficoll and immunomagnetic beads from the peripheral blood of asthmatic rats. Then


Safety Board determines the probable cause(s) of this accident as follows:The pilot's decision to continue the night, visual flight into instrument meteorological conditions, which resulted in controlled flight into terrain while on final approach. Contributing to the accident was the pilot's improper use of an electronic flight bag.The pilot reported that while approaching the destination airport, in night marginal visual meteorological conditions, he turned on the pilot controlled runway lights. He added that he began a descent to the runway, without observing the runway lights or airport, and encountered "ground fog" about 200 to 300 ft. above the ground. He further added that he continued the descent to the runway while referencing the navigational moving map and GPS altitude on his electronic flight bag (EFB) application ForeFlight. Subsequently,c, -5.
-5, x, c
Let i = -7 - -5. Sort 0.5, -1, i.
i, -1, 0.5
Let l be (3/6*37)/(-1). Let g = l - -19. Let i = 5 + -7. Put 3, g, i in increasing order.
i, g, 3
Let r(i) = i + 9. Let x be r(5). Put -1, x, 0, 5 in decreasing order.
x, 5, 0, -1
Let w be 1 + 0 - 3/7. Let c = -8/33 + 122/231. Sort c, w, -2 in descending order.
w, c, -2
Let c be (6/10)/(4/20). Let w be 3/(-2)*2/c. Let p be -2 + 1 + -7 + 11. Sort p, w, -5 in descending order.
p, w, -5
Let n be (-12)/(-8) - 1/2. Sort n, 3, -3 in ascending order.
-3, n, 3
Suppose 0 = -5*r - 132 - 78.


= -4*m, 4*f + m - 25 = 0. Sort 1, 4, -1, f in descending order.
f, 4, 1, -1
Let t be (-3 - (1 + -3))*0. Suppose r = -3*c + c + 5, -4*r - 45 = -5*c. Suppose h + c = -t. Put -2, h, -4 in descending order.
-2, -4, h
Let l = 0.19 - -1.91. Let x = l - 4.8. Let y = -3 - x. Sort y, 0.2, 0 in increasing order.
y, 0, 0.2
Let b = -5 + 9. Let r = b - 9. Suppose 5*v + 13 = -7. Put r, 4, v in descending order.
4, v, r
Let s = -10 + 14. Suppose s*x - 3 = -11. Let j be (1/x)/(2/(-4)). Sort 3, 2, j.
j, 2, 3
LetBrown with such status. In July 2011, Lawrence Larson became the school's inaugural Dean. Prior to this appointment he served as the chair of the Electrical and Computer Engineering Department in the Jacobs School of Engineering at the University of California, San Diego.

Undergraduate education
The Brown University School of Engineering offers ABET-accredited engineering concentrations in biomedical, chemical and biochemical, computer, electrical, materials, and mechanical engineering (Sc.B.). Also offered are programs in engineering-physics and environmental engineering. In addition, the Brown School of Engineering offer a bachelor of arts degree in engineering.

Master's and Ph.D. programs
The Brown University School of Engineering offers Sc.M. programs in biomedical engineering, chemical and biochemical engineering, electrical sciences and computer engineering, fluids and thermal sciences, materials science, and mechanics of solids. An integrated five-year Sc.B./Sc.M. degree is


Sciences Foundation (NSFC), the nation's top science agency. He received the Brown Engineering Alumni Medal (BEAM) Award in 2009.
 Melanie Whelan '99 is the CEO of SoulCycle.
 Frank E. Winsor, Ph.B. 1892, A.M. 1896, Sc.D. 1929, civil engineer, was the chief engineer for the Boston Metropolitan District Water Supply Commission, now the Massachusetts Water Resources Authority, from 1926 until his death in 1939 and was closely involved in the design and construction of Winsor Dam and Goodnough Dike which were built by the Commission to create the Quabbin Reservoir in Massachusetts. Winsor Dam was named for him.

See also

References

External links
 Official Web site of the Brown University School of Engineering

Category:Engineering schools and colleges in the United States
Category:Engineering universities and colleges in Rhode Island
Category:Brown UniversityPentoxifylline attenuates experimental mesangial proliferative glomerulonephritis.
Accumulation of glomerular macrophages, proliferation of mesangial cells (MCs), and deposition of extracellular matrix proteins are pathobiological hallmarks of glomerulonephritis. We previously reported that a clinically available nonselective inhibitor of cyclic 3',5'-nucleotide phosphodiesterase, pentoxifylline (PTX), inhibits proliferation of cultured rat MCs, as well as collagen production by these cells. In this study, we investigated the in vivo effects of PTX on rat anti-Thy1 disease, a model of mesangial proliferative nephritis. Anti-Thy1 nephritis was induced in Sprague-Dawley rats by injecting mouse anti-rat Thy1 antibodies intravenously. Nephritic rats were randomly assigned to receive PTX (0.1 g/kg/day) or vehicle (phosphate-buffered saline) and were sacrificed at various time points. Paraffin kidney sections were stained with hematoxylin and periodic acid-Schiff reagents for glomerular histology. Frozen kidney sections were


       System.out.print(abs>i ? "*" : i-abs+1);
        }
        System.out.println("");
    }

My output:
****1****
***121***
**12321**
*1234321*
123454321

I can't make the next step, to turn it upside down. Dose anybody hava an ideas?

A:

I have solved this exercise, but I think it is not a perfect solution. Does anybody have another way to solve this task?
public static void main(String[] args) {

        printMatrix(5);

    }
    public static void printMatrix (int n) {

        int d = n +(n-1);
        int k = n*2;
       and width size, then the best place to buy is here

Rating: [5 of 5 Stars]

Displaying 1 to 6 (of 6 reviews)

Please tell us what you think and share your opinions with others. Be sure to focus your comments on the product.


possibilities of the continuous approach is one of the aims of our paper.

In our paper, we use several different models of evolving networks (with undirected and directed links), but a skeleton of all them is the same (see Fig. \[f1\]). At each increment of time, a new node is added. Therefore, the number of the last node, $t$, may be called “time”. Each node is labeled by the time of its birth, $s=0,1,2,\ldots \leq t$. Together with a new node, several new links is appeared in the network. A part of these links is distributed between nodes preferentially according to their degrees (we notate it $k$) or in-degrees ($\equiv q$). (Out-degree distributions is discussed in only one place). In general considerations, $k$ and $q$ will be equivalent ifone may also find the degree distribution of individual nodes, $p(k,s,t)$, for large $s$ and $t$ and fixed $s/t$,

$$p(k,s,t) = \frac{s}{t} \frac{1}{(k+1)!} \ln^{k+1}\left(\frac{t}{s}\right)
\, .
\label{4--4}$$

One sees that this function decreases rapidly at large values of degree, $k$.

Thus, degree distributions of networks growing without using a mechanism of preferential linking differs strikingly from distributions of scale-free networks described in previous section. Note that the singularity of $p(k,s,t)$, Eq. (\[4–4\]), at $s/t \to 0$ is much weaker than for scale-free networks.

Linear preference {#ss-linear1}
-----------------

Let us demonstrate the continuous approach in details using a more general model than in Sec. \[s-reasons\] which produce a wide range of $\gamma$ exponent values [@dms00] (see Fig. \[f1\],a). Let us consider a network with directed links. Here, we study distributions of numbers of [*incoming*]{} links


is more or less all – your page is in the World Wide Web. There is another way of appearing of new documents in the Web. Imagine that you already have your personal home page and want to launch a new document. The process is even simpler than the one described above. You simply insert at least one reference to the document into your page, and that is enough for the document to be included in the World Wide Web. If the process of appearing of each document in the Web is as simple as the creating of your page – only one reference to the new document $(n=1)$ – and if one forgets about the terms $n_r$ and $A$ in Eq. (\[6–4\]), than, for the $\gamma_{in}$ exponenthalf a year) changes $\gamma$. The ratio between the total number of links and the number of nodes in the Web is not constant [@bkm00], it increases with time, the growth of the Web is nonlinear. This factor also change the value of $\gamma$, in future it may become even lower than $2$, see [@dm00c] and Section \[s-accelerating\].

[**(c)**]{}  Above we discussed the distribution of incoming links. Eq. (\[6–4\]) may be also applied for the distribution of links which come out from documents of the Web, since the model of the previous section may be reformulated for outgoing links of nodes. In this case all the quantities in Eq. (\[6–4\]) takes other values which are again unknown. Nevertheless, one may think that the number of the links distributing without


or $\beta_0$, that is the exponents of the network in which all nodes have equal strength, $g=1$.) The first line of Eq. (\[19–1\]), in this case, looks as

$$\frac{\partial \overline{q}_{\tilde{s}}(t)}{\partial t} =
\frac{g m}{m+n} \frac{g \overline{q}_{\tilde{s}}(t)}{t}
\, .
\label{19--2}$$

Hence, at long times, $\overline{q}_{\tilde{s}}(t) = const(q_i)\, t^{gm/(m+n)}$, and we see that the in-degree of the strong node does grow slower than $t$ only for

$$g < g_c \equiv 1 + \frac{n}{m} = \gamma_0 - 1 = \beta_0^{-1} > 1
\, ,
\label{19--3}$$

so we obtain the natural threshold value.

In the other situation, $g>g_c$, at long times, we have the only possibility, $q_{\tilde{s}}(t) = d\, t$, $d$ is some constant, since more rapid growth of $q_{\tilde{s}}(t)$ is impossible. $d < m+n$. This means that, for $g>g_c$, finite part of all preferentially distributed links is captured by$\beta<1$ and $\gamma>2$ for any positive $\alpha$ and $B$. The scaling regime is realized if $B\alpha<1$.

Note that, in both considered cases, one cannot set $\alpha=0$ directly in the obtained expression for the scaling exponents.

Developing and decaying networks {#s-developing}
================================

Now we can study evolution of network accompanied by reconstruction of its old part [@dm00b]. This, e.g., may include permanent deletion of old links or nodes. Note that the processes of addition and deletion of links may be considered in a unified way, so we study them together. For brevity, in the present section, we consider undirected links.

Developing networks {#ss-developing}
-------------------

Let us introduce two channels of appearance of new links. The first one was studied in Sec. \[ss-linear1\]. We consider undirected links, so, in our old formulas, we have to substitute $\overline{q}(s,t)


\equiv \gamma(c=0)$. Using Eq. (\[11–11\]), we obtain for the density of in-degree, $\overline{d}(s,t) \propto (s/t)^{-(\beta+c)/(1-c)}$. Note that, $\overline{d}(s \to 0,t) \to \infty$ for $c<\beta_0$, and $\overline{d}(s \to 0,t) \to 0$ for $c>\beta_0$.

The expression for the degree distribution looks as

$$\begin{aligned}
P(k,t) & = &
\frac{\int_0^t ds\, {\cal N}(s,t) p(q,s,t)}
{\int_0^t ds\, {\cal N}(s,t)} =
\nonumber
\\[5pt]
& &
\frac{\int_0^t ds\, \overline{{\cal N}}(s,t) \delta(q - \overline{q}(s,t))}
{\int_0^t ds\, \overline{{\cal N}}(s,t)}
\, .
\label{11--14}\end{aligned}$$

Therefore, repearting the derivation of Sec. \[s-scaling1\] we obtain the following distribution, $P(k) \propto k^{-(1/\beta)[c/(1-c)]} k^{-1-1/\beta} \propto k^{-1-1/[\beta(1-c)]}$, so $\gamma = 1 + 1/[\beta(1-c)] = 1 + 1/\beta_0 = \gamma_0$. Thus, the distribution is of the same form as without the permanent random deleting of nodes. Note that there is a great difference from the case of the permanent random deletion of links considered above.

Here,F^{-1}[F(1) + (\beta/c)\ln\xi]$ ($F(\kappa) \equiv \int d\kappa\,f(\kappa)$, $F^{-1}$ is an inversed function to $F$), into

$$\beta^{-1} = c^{-1}\int_0^1 d\zeta\, f_p[\kappa(\zeta)] \ \mbox{ or equivalently} \ 2 = \int_0^1 d\zeta\,\kappa(\zeta)
\,
\label{15--4}$$

find the solution $\beta$ of any of these transcendental equations.

We will not consider examples of application of these relations but describe briefly the case of a power law preference function just to test the continuous approach using the known non-scale-free network. Indeed, we have checked the quality of the continuous approach for scale-free networks. Now it is naturally to check it for other networks.

Let the preference function be $f_p(k) = k^{-y}$. If one sets

$$\int\limits_0^1 d\zeta \kappa^y(\zeta) =\mu = const
 \, ,
\label{15--5}$$

then the equation for $\kappa(\xi)$ is

$$-\frac{d\ln \kappa(\xi)}{d\ln\xi}  = \mu^{-1}\exp[-(1-y)\ln\kappa]
 \, .
\label{15--6}$$

Its solution is

$$\kappa(\xi) = (1 -\frac{1-y}{\mu}


Therefore, we see that scale-free networks are quite suitable for the continuous approach.

Natural boundaries, $s=0$ and $s=t$, are always present in growing network. We showed, that even presence of strong nodes did not lead to violation of the rule “the oldest are the richest” for nodes in the continuous part of degree-distribution. Nevertheless, we have found a threshold value of the strength of this node above that a single node influences evolution of an entire network. It captured a finite fraction of all links – giant capture – and determines values of exponents, although the network stays scale-free. These “collective” effects are explained by absence of any “interaction distance” in the process of network growth. Each node has some chance to get a new link. Therefore, in principle,33141/99. We also thank A.N. Samukhin for many useful discussions.\
$^{\ast}$ Electronic address: sdorogov@fc.up.pt\
$^{\dagger}$ Electronic address: jfmendes@fc.up.pt

R. Albert, H. Jeong, and A.-L. Barabási, Nature [**401**]{}, 130 (1999)

B.A. Huberman and L.A. Adamic, Nature [**401**]{}, 131 (1999).

R. Kumar, P. Raghavan, S. Rajagopalan, and A. Tomkins, Proc. of the 25th VLDB Conference (Edinburgh, 1999), 639-650.

A. Broder, R. Kumar, F. Maghoul, P. Raghavan, S. Rajagopalan, R. Stata, A. Tomkins, and J. Wiener, Proc. of the 9th WWW Conference (Amsterdam, 2000), 309.

A.-L. Barabási and R. Albert, Science [**286**]{}, 509 (1999).

M. Faloutsos, P. Faloutsos, and C. Faloutsos, Comput. Commun. Rev. [**29**]{}, 251 (1999).

P. Baran, [*Introduction to Distributed Communications Networks*]{}, RM-3420-PR, August 1964, $<$http://www.rand.org/publications/RM/baran.list.html$>$.

B.A. Huberman, P.L.T. Pirolli, J.E. Pitkow and R.J. Lukose, Science [**280**]{}, 95 (1998).

J. Lahererre and D. Sornette, Eur. Phys. J. B [**2**]{}, 525


With these, we estimate the CCSD(T) CBS limit of the hypothetical trimerization energy to be +0.78 eV. Thus, the trimerization is facilitated by the formation of six Ti-N bonds with a calculated formation energy of -1.32 eV per bond.Il video con i cavalli impauriti che hanno invaso la 13^ tappa del #giro , by @signorbiga pic.twitter.com/rCPNgDminP — Team Lampre Merida (@lampre_merida) May 21, 2016

When bicycles and animals come into contact the result is rarely good. Two horses joined the peloton on a descent on Stage 13 of the Giro d’Italia that took the peloton 170-km from Palmanova to Cividale del Friuli.

On a winding technical descent at the Giro d’Italia, a pair of horses galloping at speed next to the peloton were captured on video and posted on Lampre-Merida’s Twitter. The stage was won by Team Sky’s Mikel Nieve with Movistar’s Andrey Amador taking the leader’s pink jersey.

RELATED: Cyclists in South Africa embark on the training ride of all time—thanks to an ostrich

Lampre-Merida staff attempt to scare


/*
 * HDMI PLL
 *
 * Copyright (C) 2013 Texas Instruments Incorporated - http://www.ti.com/
 *
 * This program is free software; you can redistribute it and/or modify it
 * under the terms of the GNU General Public License version 2 as published by
 * the Free Software Foundation.
 */

#define DSS_SUBSYS_NAME "HDMIPLL"

#include <linux/kernel.h>
#include <linux/module.h>
#include <linux/err.h>
#include <linux/io.h>
#include <linux/platform_device.h>
#include <linux/clk.h>
#include <linux/seq_file.h>
#include <linux/pm_runtime.h>

#include "omapdss.h"
#include "dss.h"
#include "hdmi.h"

void hdmi_pll_dump(struct hdmi_pll_data *pll, struct seq_file *s)
{
#define DUMPPLL(r) seq_printf(s, "%-35s %08x\n", #r,\
		hdmi_read_reg(pll->base, r))

	DUMPPLL(PLLCTRL_PLL_CONTROL);
	DUMPPLL(PLLCTRL_PLL_STATUS);
	DUMPPLL(PLLCTRL_PLL_GO);
	DUMPPLL(PLLCTRL_CFG1);
	DUMPPLL(PLLCTRL_CFG2);
	DUMPPLL(PLLCTRL_CFG3);
	DUMPPLL(PLLCTRL_SSC_CFG1);
	DUMPPLL(PLLCTRL_SSC_CFG2);
	DUMPPLL(PLLCTRL_CFG4);
}

static int hdmi_pll_enable(struct dss_pll *dsspll)
{
	struct hdmi_pll_data *pll = container_of(dsspll, struct hdmi_pll_data, pll);
	struct hdmi_wp_data *wp = pll->wp;
	int r;

	r = pm_runtime_get_sync(&pll->pdev->dev);
	WARN_ON(r < 0);

	dss_ctrl_pll_enable(dsspll, true);

	r = hdmi_wp_set_pll_pwr(wp, HDMI_PLLPWRCMD_BOTHON_ALLCLKS);
	if (r)
		return r;

	return 0;
}

static void hdmi_pll_disable(struct dss_pll *dsspll)
{
	struct hdmi_pll_data *pll = container_of(dsspll, struct hdmi_pll_data, pll);
	struct hdmi_wp_data *wp = pll->wp;
	int r;

	hdmi_wp_set_pll_pwr(wp, HDMI_PLLPWRCMD_ALLOFF);

	dss_ctrl_pll_enable(dsspll, false);

	r = pm_runtime_put_sync(&pll->pdev->dev);
	WARN_ON(r < 0 && r != -ENOSYS);
}

static constPCR, cDNA from liver and skeletal muscle was synthesized using the iScript cDNA synthesis kit (Bio-Rad) according to the manufacturer\'s instructions. Real time quantification was performed using iQ SYBR Green Super mix (Bio-Rad). The primer sequences are described in Table S1.

2.3. Immunoblots {#s0025}
----------------

Protein lysates were prepared from muscle and liver using RIPA buffer (50 nM NaCl, 20 mM Tris, pH 7.5, 1 mM EDTA,1% NP40, 0.1% SDS, 0.5% Na deoxycholate), protease inhibitors and phosphatase inhibitors (Roche Applied Science). Quantification was performed using Bio-Rad Dc Protein Assay (Bio-Rad). Lysates we subjected to electrophoresis on TGX™ precast gels (Bio-Rad) and transferred to Immune-Blot® PVDF membrane (Bio-Rad). Membranes were incubated with primary and secondary antibodies listed in Table S2, developed with chemiluminescence ECL Western blotting detection solutions (GE Healthcare) and exposed to autoradiography film (HiBlot


but interestingly not to levels typically observed during starvation or exercise. Tfr1^mu/mu^ muscle showed diminished anaplerotic amino acids, consistent with increased amino acid catabolism in an attempt to fuel the TCA cycle. Aspartic acid, one of the anaplerotic amino acids, is also used for several transamination reactions. Importantly, there were decreased levels of lactate and alanine, both precursors for gluconeogenesis that are typically shuttled from muscle to liver during starvation and exercise.

We observed increased muscle citrate, usually a signal of plenty, which can inhibit phosphofructokinase and glycolysis and may inhibit β oxidation indirectly. At the same time, impaired oxidative phosphorylation may lead to an increased AMP/ATP ratio and activation of AMPK (Fig S3A), which is a signal of energy insufficiency. In addition to these mixed signals, we observedwas a strong signature for hepatic fatty acid catabolism, with markedly elevated even chain acylcarnitines.

Serum from Tfr1^mu/mu^ mice was also more severely affected at P6 than P4. The older mice had increased C4OH suggesting increased ketone delivery or ketolysis in tissues such as muscle and heart. There was a robust increase in several long chain acylcarnitines derived from long chain acyl-CoA intermediates of β oxidation. As noted earlier, all amino acids were strongly diminished, likely contributing to the failure of gluconeogenesis.

3.7. Proteomic Analysis {#s0100}
-----------------------

To further evaluate the phenotype, we subjected muscle proteins from P6 (late) WT and Tfr1^mu/mu^ mice to mass spectrometry-based proteomic analysis. We assessed relative protein expression levels and lysine acetylation modifications (data online at <https://massive.ucsd.edu/ProteoSAFe/static/massive.jsp>, ID MSV000079328). The relative expression levels of most proteins were


very difficult in newborn mice.

Metabolic changes were not limited to skeletal muscle, although Tfr1 was only deficient in that tissue. Body fat pads disappeared, suggesting that lipolysis ensued, presumably to provide a source of energy for muscle, and the liver became steatotic. Tfr1-null muscle showed increased expression of *Angptl4* mRNA, suggesting a starvation-like response. Starvation should promote lipolysis for increased fatty acid delivery to the muscle, but failure of the ETC would preclude effective β oxidation. We do not know why the levels of acylcarnitines were lower in muscle than liver, but this might suggest a defect in muscle fatty acid uptake or in the activity of carnitine palmitoyltransferase 1 (Cpt1). The presence of lipid droplets in the diaphragm was consistent with increased fatty acid delivery and decreasedIron regulatory protein (IRP) binding to a biotinylated iron regulatory element (IRE) probe in P6 Tfr1^mu/mu^ muscle compared to WT (WT n = 5, Tfr1^mu/mu^ n = 4; 129 background).\
(E,F) Levels of representative proteins for complexes I (Ndufb8), II (Sdhb), III (Uqcrc2), and IV (Mtco1) in muscle from P6 Tfr1^mu/mu^ mice compared to WT. The amount of ATP5A, a protein component of complex V, appeared unchanged and was used in panel F to normalize for relative intensity (WT n = 6, Tfr1^mu/mu^ n = 6; 129 background).\
(G) Enzymatic activity of Complex II in P6 Tfr1^mu/mu^ muscle compared to WT (WT n = 5, Tfr1^mu/mu^ n = 3; 129 background).\
(H,I) Fe--S containing protein Ndufs3 in P6 muscle from Tfr1^mu/mu^ mice \[ribosome protein L19 (Rpl19) loading control; WT n = 5, Tfr1^mu/mu^ n = 4; 129 background\].\
All panels: error bars represent standard deviation; \* p ≤ 0.05, \*\*


testing times. The data representing the results of the test are often stored in a memory of a glucose meter. The data is then downloaded into a computer for later review. However, none of these systems coordinate infusion pump data with the glucose meter data. Also, these systems generally only download raw data and do not provide for analysis and presentation of the data in a useful format.# malformed
        msg = r"Replacement lists must match in length\. Expecting 3 got 2"
        with pytest.raises(ValueError, match=msg):
            ser.replace([1, 2, 3], [np.nan, 0])

        # make sure that we aren't just masking a TypeError because bools don't
        # implement indexing
        with pytest.raises(TypeError, match="Cannot compare types .+"):
            ser.replace([1, 2], [np.nan, 0])

        ser = pd.Series([0, 1, 2, 3, 4])
        result =


corrupted when fillna call fails
        s = ser.copy()
        msg = (
            r"Invalid fill method\. Expecting pad \(ffill\) or backfill"
            r" \(bfill\)\. Got crash_cymbal"
        )
        with pytest.raises(ValueError, match=msg):
            s.replace([1, 2, 3], inplace=True, method="crash_cymbal")
        tm.assert_series_equal(s, ser)

    def test_replace_with_empty_list(self):
        # GH 21977
        s = pd.Series([[1], [2, assert (ser[20:30] == -1).all()

    def test_replace_with_empty_dictlike(self):
        # GH 15289
        s = pd.Series(list("abcd"))
        tm.assert_series_equal(s, s.replace(dict()))

        with tm.assert_produces_warning(DeprecationWarning, check_stacklevel=False):
            empty_series = pd.Series([])
        tm.assert_series_equal(s, s.replace(empty_series))

    def test_replace_string_with_number(self):
        # GH 15743
        s = pd.Series([1, 2, 3])
        result = s.replace("2", np.nan)
        expected = pd.Series([1, 2, 3])


Trial Information

This is a phase II, open label study to determine the efficacy and safety of treatment with
MEK162 in patients with a diagnosis of select solid tumors or hematological malignancies
that have been pre-identified (prior to study consent) to have activations of the
RAS/RAF/MEK pathway and whose disease has progressed on or after standard treatment.

Genomic profiling is becoming more accessible to patients and their physicians. This is a
signal-seeking study to match patients with mutations in RAF, RAS, NF1 or MEK to the
ATP-noncompetitive MEK 1/2 inhibitor, MEK162. Pre-identification of these mutations or
activations in the pathway will be performed locally at a CLIA certified laboratory prior to
screening for participation on the trial.

Once the patient has been identified, treating physicians who are qualified investigators
may contact Novartis to consider enrollment in this study. Fora mutation in RAF, RAS, NF1 or
MEK at a CLIA certified laboratory

- Patient must have received at least one prior treatment for recurrent, metastatic and
/or locally advanced disease and for whom no standard therapy options are anticipated
to result in a durable remission.

- Patient must have progressive and measurable disease as per RECIST 1.1. or other
appropriate hematological guidelines.

Type of Study:

Study Design:

Outcome Measure:

Clinical benefit rate associated with MEK162 treatment

Outcome Description:

Clinical benefit rate for patients with solid tumors will be assessed using RECIST 1.1 and will include responses of CR or PR or SD. For hematologic tumors other appropriate hematological response criteria will apply

Name

Location

We are a Cancer Social Network, Resource Directory & Education Hub supporting all those affected by cancer. knowcancer.com is intended to be solely for informational purposes and should


    “When a motion to dismiss challenges the constitutionality of a statute, we

review de novo the interpretation of the statute by the district court.” United States

v. Spoerke, 568 F.3d 1236, 1244 (11th Cir. 2009). The Second Amendment states

that “[a] well regulated Militia, being necessary to the security of a free State, the

right of the people to keep and bear Arms, shall not be infringed.” U.S. Const.

amend. II. Pursuant to § 922(g)(1), it is unlawful for a convicted felon to possess a

firearm or ammunition. 18 U.S.C. § 922(g)(1).

      In Heller, the Supreme Court addressed the constitutionality of a District of

Columbia statute that generally prohibited the possession of handguns. 554 U.S. at

__,128 S.Ct. at 2788. The Supreme Court held that “the SecondNichols, 124 F.3d 1265, 1266 (11th Cir.

                                          4
1997); see also United States v. McAllister, 77 F.3d 387, 390 (11th Cir. 1996)

(holding that § 922(g)(1) was not unconstitutional as applied to a defendant who

only possessed a firearm intrastate because “§ 922(g) is an attempt to regulate guns

that have a connection to interstate commerce”). Thus, the district court did not err

by finding that § 922(g)(1) does not violated the Commerce Clause.

      Battle next argues that his mandatory minimum sentence of 180 months’

imprisonment pursuant to


on the copyright of the company (Sweetsong) that took a graduation video." She stated that she "used the CAS Cable Livestream of the graduation" and was not claiming the video she included as her own.

The similarities between her edited video, which features the speech of her principal, as well as Ashton Kutcher's 2013 Teen Choice Awards acceptance speech, is rather uncanny.

"It's really three things that I want to share. And those who really know me know that I'm very blunt, to the point, so I'm going to spill the tea with you right now," principal Kenneth DeMoss said in his speech. "The first thing is about opportunity, the second thing is about being intriguing, and the third thing is about living life."

Kutcher, in his 2013 speech, said: "It'she doubted very much that the Baltimore protesters would buy it, either, saying, "They will not be convinced by the Washington Post report that this fellow died as a result of self-inflicted wounds."

This outraged Hannity. "So the facts be damned!" he bellowed.

That’s right. He said facts. Facts are those things that police say in Hannity’s world. No matter how nonsensical. Why was Rivera not on board with this?

Mainly Hannity just wanted to attack Obama, though. If the Washington Post report is true, Hannity said, which no one in their right mind thought for a moment, “That means the President of the United States has injected himself wrongly four times in four high-profile race issues. That makes him a four-time loser.”

Advertisement:

Oh God. Shut up, Hannity, you million-time loser. We


requiring K^+^ binding, similar to those reported by the Plavec group ([@B44]). Here we observed the same CD spectra with and without pre-annealing of the solution.

![Circular dichroism titrations (20°C) of 10 μM (**A**) 24TTG, (**B**) 23TAG and (**C**) 22GT in 100 mM TMAA with increasing amount of KCl (0 in yellow, 25, 50, 75, 100, 200, 500 in gray and 1000 μM KCl in red). (**D--F**), CD spectra reconstructed for the 0-K^+^ (green), 1-K^+^ (blue) and 2-K^+^ (orange) complexes, for sequences (D) 24TTG (the 1-K^+^ complex was not abundant enough to reconstruct a CD spectrum), (E) 23TAG and (F) 22GT.](gkw970fig3){#F3}

The CD spectra change upon KCl addition to the oligonucleotides, indicating a structural change induced by K^+^ binding. For 24TTG, the folding into a hybrid G-quadruplex occurs at lowsite, the negative band at 260 nm becomes less negative, due to the triplet stacking, resulting in a hybrid-like CD spectrum ([@B26]). Mechanistically, given that no dramatic topology rearrangements is required between the 1-K^+^ and the 2-K^+^ structure, the K^+^ binding events could be sequential.

The 21G and 22AG sequences have similar K^+^ binding characteristics as 22GT, suggesting potentially similar folding pathways. Interestingly, the sequence d(A(GGGTTA)~3~GGGT), a close derivative of both 22GT and 22AG, was also shown to form an antiparallel G-quadruplex with two quartets in potassium ([@B64]). So, although the 22AG sequence folds into an antiparallel 3-quartet G-quadruplex in NaCl ([@B27]), it may form a 2-quartet, antiparallel structure at low KCl concentrations. A very similar CD spectrum has previously been deconvoluted by Bončina *et al.* for 22AG in presence


information that the antiparallel structures actually contain only one specifically bound potassium ion.

The sequence-dependent K^+^ binding cooperativity {#SEC4-2}
-------------------------------------------------

Past reports based on DSC also showed that the Δ*G*° of folding of human telomeric G-quadruplexes could vary by up to ∼7 kcal/mol from one human telomeric sequence to another ([@B78]). The large differences can actually be correlated to the influence of a single nucleotide on the K^+^ binding constants and binding cooperativity. Here, we show that the K^+^ binding constants (and therefore the Δ*G*° values) are highly influenced even by a single flanking base or by flanking fluorophores.

In traditional spectroscopic methods, the binding cooperativity can be assessed by the Hill coefficient ([@B79]). For the short variant 21G (d((GGGTTA)~3~GGG)) ([@B66]), a Hill coefficient of 0.9 ± 0.1 was obtained by theBalasubramanian group. This indicates a non-cooperative binding of K^+^, in agreement with our results on the shortest sequences. The authors also reported a positive cooperativity with a Hill coefficient of 1.8 ± 0.1 for TERRA, a parallel RNA G-quadruplex. Our experiments on Pu24 show that the K^+^ binding to this parallel G-quadruplex is also very cooperative. The Chaires group also commented on potassium (and sodium) binding cooperativity, and showed that adding nucleotides increases the binding cooperativity ([@B80]). Our results are in line with previous studies, but the ability to quantitatively determine the individual *K*~D~ values for the first and second potassium binding event (Equations 2 and [3](#M5){ref-type="disp-formula"}, Table [1](#tbl1){ref-type="table"}) refines the interpretation of equilibrium binding data obtained from calorimetric or spectroscopic studies. Similar effects have been reported when terminal


What I Learned After Banning Screens from My Home for a Month - ohjeez
https://motherboard.vice.com/en_us/article/what-i-learned-after-banning-screens-from-my-home-for-a-month
======
djsumdog
I really like the Penny Arcade take on "screen time":

[https://www.penny-arcade.com/comic/2014/06/30/](https://www.penny-
arcade.com/comic/2014/06/30/)

------
bhgraham
Lots of flies

capital all around the world.

On the domestic side, you really can’t analyze any issue without understanding the magnitude of military spending, whether it be Flint’s water in Michigan, whether it be the just ridiculous defunding of public education. This is all ridiculous. Because when you compare it to the vast amounts of military spending that we’re seeing around the world with the U.S., and when it comes to international issues, you cannot view any international issue without seeing it through the lens of the colonizers and colonized.

We are trying to reclaim the narrative set by history’s colonizers and imperialists. As we know, history has been written by the winners—until the advent of social media. And we’re changing that every day. So we’re finally showing the reality of Palestine,


of these boards of directors—it’s just a couple hundred that sit on these boards of corporate media entities—sit on interlocking boards with Boeing, with banks, with Monsanto. Of course they’re going to protect their interests, that supersede the interests of the media corporation. Again, it all comes down to profit and protecting that capital.

Then there is this revolving door with telecom lobbyists that go straight into government. We saw Tom Wheeler, head of the FCC under Obama. He was essentially just a lobbyist. And, of course, Ajit Pai is just the biggest lobbyist shill for telecom I’ve ever seen, who is now running it under Trump.

But to think of corporate media as beyond the CNNs, beyond MSNBC, beyond Fox. We all know that that’s a joke. There isthe war. All of this has been erased from the national consciousness. Not only that, but you see the same Iraq War architects now being lauded on corporate media as Russia experts and resistance leaders. It’s very, very stunning to me.

This same system, this corporate media apparatus, does not uplift radical voices, obviously. They don’t uplift any voices that are on the margins because anyone who is radical and going to be challenging that reigning orthodoxy is a threat. It’s very obvious why they don’t allow these voices in the system. And when they do, they have to mock them, they have to marginalize them. Look no further than Dennis Kucinich. All they had to do was say that he saw an UFO and he was out. He


with all this bemoaning about free speech on campus and how we can’t allow conservatives to have free speech, well, behind the scenes Robert Mercer and other right-wing billionaires are actually passing legislation on campus to restrict actual free speech, actually expel students who protest. That’s incredible. That’s happening. Lead contamination around the country, there are certain cities that have lead contamination three times Flint’s at its highest. These are things that we should know. Of course, the big banger is that the Army has spent $6 trillion that it cannot account for of taxpayer money. Six trillion dollars. Wow, that could be spent for a lot of good here.

It’s not just this, though. It’s also algorithms. We look at net neutrality. This is a huge fight rightmedia domination, because there are some outlets, of course, that don’t rely on corporate sponsorship, they rely on state funds—like Russia Today, like TeleSUR, like CCTV and Press TV coming out of the Iran. They fit outside of the periphery of Western news domination and that corporate domination, and they really allow spaces, good or bad, you could argue, for radical voices that are not allowed on mainstream platforms, that rebuke corporations and the war machine.

So I decided to join RT. What I quickly realized in D.C. is access is the game, baby, access is the game. A really quick story. Right when I got there, right out of the gates, I made a press pass for myself before I even got one from RT for Media Roots.


just speak my mind on air.

And I did several times. I spoke out against the MH17 flight that was shot down, potentially by Russian insurgents. And Ukraine, I talked openly about that. I talked about the Crimean incursion, just about the coverage that I didn’t agree with. It reminded me a lot of the Iraq War coverage, where it showed soldiers getting greeted with cookies and flowers. And while that was happening, I felt like it was too one-sided from RT. The fact that I was able to do that and I told my boss, “If you don’t let me do this, I’m going to walk out,” showed me that everyone could do that. Literally, anyone working in media could do that. They could put their jobs onway for Trump, I guess. This is a show that ended two years before the election that they were saying was literally the example of why Russian propaganda cost us Hillary. Once I saw my show in the official intelligence report, I was just, like, this is utter madness. Literally half of the report is about RT.

It’s not like we’re on there praising Putin. You can even look at the report and see what is considered this dangerous propaganda that we were fomenting radical discontent about. Literally telling the truth about this country. Fracking, things that have huge social movements behind them are now just dismissed as Russian propaganda. This DNI report says my show, talking about Occupy Wall Street, talking about greed and inequality, in a country


job.” You just can’t touch it. I am so smeared with the Israel stuff. For example, because of the Israeli lobby, Al Jazeera just had to cancel a documentary that was basically exposing the multiple spy fronts of Israel operating within this country to smear its critics. So that’s going on. Who knows the extent of that operation?

A really quick story. When I was at RT, back during Operation Pillar of Cloud—of course, every couple years Israeli soldiers just massacre a bunch of Palestinians in Gaza. This was no different. This was Operation Pillar of Cloud. They have really bizarre names for their genocidal operations. But there is a tower in Gaza called the al-Shorouk journalists’ tower, and it housed RT, it housed France 24, and several otherthe CIA on the ground, like I said, doing soft regime-change operations in Venezuela.

So I went there to see with my own eyes. Until you go, it’s hard to know the truth, because the media is literally all saying one thing. TeleSUR is funded in part by Venezuela. And before I moved I had a meeting with the producer who buys the show, and I was, like. “Look, I’m going to tell exactly what I see. You know me. Just to let you know, I’m going down there with a completely open mind, and I’m going to report exactly what I see.” He said, “I wouldn’t expect you to do anything else.” That’s exactly what I did.

I was stunned to learn that it’s pretty much the opposite of


phenomenon is really interesting, because, let’s face it, he is right in a way. The corporate media is the largest purveyor of fake news. They really are, in terms of war selling and manufacturing consent with the empire when it comes to military and hegemony around the world. The reason that they hate Trump so much is because he removes the mask. They don’t like that. They want empire to be palatable. They want it to be professional and distinguished, like Obama and like Hillary. That’s why you saw so many media conglomerates completely invested in Hillary’s campaign. She got the most donations from those big corporate media donors.

They don’t care that Trump is xenophobic or racist or bigoted. Their policies are. What do you think war is?growing anti-China campaign and the suppression of a warning of world war.

With many if not most independent journalists barred or ejected from the “mainstream”, a corner of the Internet has become a vital source of disclosure and evidence-based analysis: true journalism. Sites such as Wikileaks, Consortium News, WSWS.org, Truthdig,, Global Research, CounterPunch and Information Clearinghouse are required reading for those trying to make sense of a world in which science and technology advance wondrously while political and economic life in the fearful “democracies” regress behind a media facade of narcissistic spectacle.

In Britain, just one website offers consistently independent media criticism. This is the remarkable Media Lens — remarkable partly because its founders and editors as well as its only writers, David Edwards and David Cromwell, since 2001 have


concentrated their gaze not on the usual suspects, the Tory press, but the paragons of reputable liberal journalism: the BBC, the Guardian, Channel 4 News.

Their method is simple. Meticulous in their research, they are respectful and polite when they ask why a journalist why he or she produced such a one-sided report, or failed to disclose essential facts or promoted discredited myths.

The replies they receive are often defensive, at times abusive; some are hysterical, as if they have pushed back a screen on a protected species.

I would say Media Lens has shattered a silence about corporate journalism. Like Noam Chomsky and Edward Herman in Manufacturing Consent, they represent a Fifth Estate that deconstructs and demystifies the media’s power.

What is especially interesting about them is that neither is aintensifying, the ability to receive funds appears to have been cut-off completely.

Contract TeleSUR journalists elsewhere, including at Empire Files, have had funding blocked by the US government for over 6 months. Even wire transfers not originating in Venezuela, but ally countries which also fund TeleSUR, have been severed.

There appears to be no solution, and no end in sight, to this ongoing financial attack.

The Empire Files officially halted all production on May 27, and had to cut all staff prior to that. But we have been holding-off on an official announcement in hopes that the wall put in place by the Trump Administration would be overcome.

We are making this announcement now because, after numerous attempts and constant rejections of all types of fund transfers, we do not believe this


had really unfortunate timing. Words always come to me when I’m in inconvenient places. Like meijer. or in the shower. Then by the time I get to my laptop I’m either too tired or have forgotten the eloquent prose (ha) that so beautifully came to me.

I guess you’re just going to have to settle for the non-prose version.

I feel like I’m on a roller coaster ride of emotions- some days I am SO happy with my life: college graduate, job with awesome kiddos, awesome boyfriend who I’ll probably get engaged to within the next 2 years (PRESSURE. haha, I can’t help it… I’m in the wedding business now with my internship- it’s hard not to start planning my own! Sorry T! I love you!), said mentioned wedding internship,pity party, there has been many occasions in my life growing up where things would seem to be awesome for 5 seconds until they weren’t. Super cute guy likes you? Jk he has a girlfriend. Wow, these girls are awesome and seem to get me… JK they talk about you behind your back and secretly hate you. It’s your senior year and theatre is your life and you’ve worked your butt off for four years so you think you finally have a shot at a non-chorus role in the school musical? HA. Don’t even get me started.

I came up with this theory in high school: Out of the three things I wanted/needed most in life- best friends, involvement in something I feel passionate about (whether a school play,


kept informed."

Rare cases

There have been a handful of cases in recent years where senior overseas commanders have been ordered to step down because of allegations of inappropriate relationships.

In at least one case, the accusations were later found to be baseless.

The statement by military police effectively removes any suggestion Norman's suspension might be related to the ongoing campaign to stamp out sexual misconduct and abuse within the ranks.

That scandal has shaken National Defence to its core.

Some in the defence community, such as Drapeau, have been concerned about the seemingly arbitrary way senior brass have handled cases involving high-ranking officers.

The example often cited is the former commander of Canadian peacekeeping troops in Haiti, retired colonel Bernard Ouellette. He was stripped of his post after allegations were made of an "inappropriateby Nancy Holder
The Kindness of Surrender by Kurt Fawver
The Angel of Isisford by Brian Craddock
Pride by Amber Benson
Button, Button by Ernie Cooper
I Am the Night You Never Speak Of by C. Robert Cargill
The Devil Until the Credits Roll by Weston Ochse
The Lighthouse of Midian by Ian Rogers
Lakrimay by Nerine Dorman
And Midian Whispered Its Name by Shaun Meeks
Cell of Curtains by Timothy Baker
Tamara by Paul Salamoff
Raphael’s Shroud by Karl Alexander
Wretched by Eddie Brauer
A Monster Among Monsters by Stephen Woodworth and Kelly Dunn
The Jesuit’s Mask by Durand Welsh
Rook by Rob Salem
Collector by David Schow
Bait and Switch by Lilith Saintcrow
The Farmhouse by Christopher Monfette

Yep, that’s me in a book with one of the biggest names in horror on the cover. With his introduction. Which means HE read my story and liked


"If your sunbae's work is not finished yet, your work is not finished yet!" "How can the newbie get away?" "I should have known, from the start, when you had the photo of that celebrity as your desktop." "She's my girlfriend." "Shut up!" "If your girlfriend is Cheon Song Yi, then my wife is Kim Nam Joo?" "(His co-star in "My Husband has a Family.")" "Your mental state is rotten!" "People who work in our company, even part-timers, put pictures of people related to them or family pictures, in order to generate more determination." "'I need to feed and save my family'." "'I need to do my best', that type of determination." "Strong determination!" " Is that so?" " What "Is that so?"!" "Change your outlook." "Go andbook from the Joseon times?" "So old-fashioned and boring." "Do you think all the old stuff is boring?" ""Kuunmong" was a new type of fantasy novel, written during the Joseon era." "Of course it's 400 years ahead than of Harry Potter, but it's a masterpiece that is of quality." "Look here." "I've been curious since a while ago." "What year were you born?" "HEY!" "You rascal." "You haven't been coming home." "Where have you been all along?" "Where is this girl hurt that she went to the emergency room?" "What do you mean 'this girl'?" "She's your older sister." "Anyway, let's go in already." "Wait a second." "Oh, Representative Ahn!" "Here!" "Ah, yes." "Ah, Mother." "These are the director and staff who are shooting the "Cheon Song Yi


type of person who would make such a mistake." "Get Driver Jang ready." "Let's go straight to the funeral." "I got it." "I should look fragile and pure, but not shabby." "Okay." "Look." "Isn't my hair parted too intentionally?" "You know..." "A look which is kind of messy and frizzy, as if I just got out of bed." "But, with a sexy side to it..." "You know those concepts when we make fabric softener commercials..." "I will blow dry your hair again." "Noona, I looked everywhere, but couldn't find your heels." "Why wouldn't they be there?" "I wore them on my way to hospital." "I heard that professor took your stuff." "How come those heels are missing when everything else is there?" "Those heels..." "Are those yours?" "WhatLenswood flying high with apple exports

Lenswood flying high with apple exports

Exports have long formed a part of the Lenswood Cold Stores Co-operative Society’s business, but new apple varieties, innovations in the packing shed and new relationships with overseas customers are helping to boost the iconic South Australian business’ profile on the world stage.

Even in the early days of the co-operative, soon after its inception in 1933, Lenswood exported crates of apples to the United Kingdom.

While exports have ebbed and flowed over the past 84 years, in recent times the co-operative has put considerable effort into building that side of the business and that effort is now starting to pay dividends.

Over the past five years, Lenswood’s exports have grown from one per cent of its business to eight per


of our brand development focus and push.

“What we like about RedLove is that it’s not just a good fresh apple, but it is also an apple for homemade apple sauce, apple pies, cheese plates and other home cooking uses. It doesn’t go brown when you cut it. You can cut it and leave it out for two days and there’s nothing wrong with it. It is going to be a unique proposition.”

James believes these varieties will only help to boost Lenswood’s footprint on the world stage due to their unique nature. This is part of a broader strategy for the co-operative of not locking itself into the domestic market.

“Everything we produce has got to be for the domestic market but must also have export potential,” says James. “Ifthere is no export potential for the variety then there’s no point looking at it.

“All of our markets are looking for new, innovative varieties like Rockit, MiApple and RedLove and we have a lot of excitement brewing around these varieties.

“We’ve had a good run on the domestic market and now we’re very excited about the export potential with them, especially with Rockit and MiApple.”

Rockit- a very unique miniature apple and is sold in a tube.

Growers on board

Most of Lenswood’s growers understand the need for exports due to the current glut of commodity varieties in the domestic market exceeding consumer demand and thus leading to lower returns for the grower.

James believes the longevity of the Australian apple industry lies in finding niche export markets so growers can receive a


be considered a small dog but we’ve got a very loud bark.”

Acknowledgement

Thank you to the team at Lenswood for helping in the preparation of this article and to Brenton Edwards of Stories Well Told for his photography.

This article has been prepared as part of the National apple and pear grower communications program that is delivered by APAL and funded by Hort Innovation using the apple and pear industry levy funds from growers and funds from the Australian Government.   Id. at 492, 89 S.Ct. at 1136.  The Court emphasized the rule's purpose and its importance in our criminal jurisprudence.

3
Moreover, the rule must not be taken lightly.  Presentence reports are documents which the rule does not make available to the defendant as a matter of right.  There are no formal limitations on their contents, and they may rest on hearsay and contain information bearing no relation whatever to the crime with which the defendant is charged.  To permit the ex parte introduction of this sort of material to the judge who will pronounce the defendant's guilt or innocence or who will preside over a jury trial would seriously contravene the rule's purpose of preventing possible prejudice from premature submission of the


The British Are Cumming

Lily Madison lists her special talents, assets and skills.
"I can crush beer cans in my rack. I have huge natural boobs. I have awesome tattoos. I'm super-polite to everyone. I can balance lots of things on my head."
We have seen this can-crushing and her balancing skills in Lily's first SCORELAND video.
"I really love swimming, and don't make any jokes about whether my breasts float. They do, of course. I like decorating cookies, taking photos and going to music festivals."
When Lily returned to England after her first visit, she took the time to arrange for a cake to be sent to the SCORE studio as a thank you.[The DA240-4 discrete biochemical autoanalyser].
The principle of operation, design and main technical characteristics are described of a discrete biochemical autoanalyzer DA240-4 jointly elaborated by the USSR and GDR. This unit can be employed in big biochemical laboratories and in prophylactic institutions.


right time on a controller, so be sure to get used to reaching over and pressing “H” just as you perform the action when your Momentum bar fills.

Don't forget you can fill the bar up to three times for exponentially more powerful effects, which is frequently necessary during boss battle.

In addition to Momentum, there's another associated mechanic that isn't explained very well in the tutorial. Fluxation and Singularity are random events that only occur when you use Momentum. It isn't guaranteed to happen every battle, but the more often you engage Momentum with Tech skills the more likely they will occur.

The bonuses provided by Fluxation - which pop when using Talismans with Flux - are also randomly chosen each time the event occurs. On your 200th instance ofMehbooba to start her public outreach campaign soon

Former Chief Minister Mehbooba Mufti Wednesday decided to reach out to her constituents in Kashmir with her old “ baaji” – elder sister image to reconnect with the people .

Mehbooba Mufti who had been secluded from her supporters and sympathisers by the administrative set up and coterie in the party has now decided to take a plunge , according to sources.

“ To me , my party is no less important than my family,” she told her party leaders who met her in the past couple of days . She appeared to be quite confident that she can bring the PDP back to its glory and show much greater results than ever before since the party was born in 1999.

The party legislators


could completely understand that dynamic.”

Kurzel was also intrigued by Bunting (charismatically played by TV actor Daniel Henshall), whose sociable nature defied the clichéd image of the serial killer as loner.

Originally from Queensland, he fitted in so well that people trusted him to look after their kids and attend parent-teacher interviews. Usually, as Kurzel observes, “serial killers are kind of hermits and work alone. Well, this guy was able, for six years, to work with three other perpetrators, and be very visible in the community. [When the murders were discovered] it wasn’t like, ‘Who is this person?’ It was someone who was a neighbour. It was all happening in suburbia. It was happening just down the road from a school. It was happening during the day.”

Part of the reasonto the experiences and the situation around him, and who, I think, suddenly found a voice.”

When Kurzel and his team moved in to the community where the crimes took place, and started conducting interviews with locals, they discovered that many people were still under the illusion that Bunting’s victims were all paedophiles and sex offenders, whereas he’d also targeted the disabled and the vulnerable.

“My feeling is that he had an ideology at the beginning, and it’s definitely something we explored,” says Kurzel. “But he had this psychopathic nature and that ideology suddenly shifted into a very sadistic need to kill.”

If some people apparently found comfort in the idea that Bunting was just killing paedophiles, does that mean that the attitudes that allowed the murders to happen still exist


White Noise" (The Journal of English Language and Literature)
2002: "The Transformations of Jouissance in a Mythic Knowledge" (Journal of Lacan & Contemporary Psychoanalysis)
2002: "Butler's Queer Theory and Psychoanalysis" (Feminist Studies in English Literature )
2002: "A Gesture Life as Gaze: the Multicultural Ethics of Lacan and Chang-Rae Lee" (The Journal of English Language and Literature)
2003: "Toni Morrison's Sula: The Real and the Politics of Body" (Studies in Modern  Fiction)
2003:  "The Return of Aesthetics: The Real in Slavoj Žižek's Psychoanalysis" (The Journal of Criticism and Theory)
2004: "The Eternal Return: Beyond the Opposition of New Historicism to Psychoanalysis (Modern Studies in English Language & Literature)
2004: "Return to Freud: Does Lacanian Signifier Mean Love or Hate?" (Journal of Lacan & Contemporary Psychoanalysis)
2004: "The Politics of Negativity: Adorno and Chuang-Tzu"speed of the motor vehicle driving ahead or the target object, such that a distance control contained in the “active cruise control” or in the corresponding cruise control system will automatically maintain a predefined distance from the vehicle driving ahead or the target object, which is suitable for the situation. As a rule, such distance-controlled cruise control systems are active or can be activated only to a minimal speed of, for example, 30 km/h, but can be expanded by a so-called stop-and-go function, so that a distance-related cruise control can take place until the vehicle is stopped or from a stopped position.
When the predefined desired speed deviates from the current speed or when following the predefined distance to the target object deviates from the current distance, within the


Patent Document DE 10 2006 056 631 A1, a method of controlling speed and/or distance for motor vehicles having distance-controlled cruise control systems is known whereby, for determining a desired acceleration value and/or a desired deceleration value for reaching a predefined speed and/or a predefined distance with respect to a vehicle driving ahead, the current traffic situation is taken into account such that, from the data for determining the current traffic situation, a traffic jam probability value is determined, and, as a function of the traffic jam probability value, an optimal desired acceleration value and/or desired deceleration value is determined. In this case, the data for determining the current traffic situation supply environment-monitoring sensor data and/or operating data of the motor vehicle.
Furthermore, from German Patent Document DE 10Q:

How can I customize the colorbar in plotly scattergeo?

I pulled some fire data from the NASA earthdata website (fires in south america) and plotted the data on a world map. I used a colorbar to display the brightness of each fire.
The variance in brightness of the fires does not correspond to the full colorscale range and most of the fires are in the same color (yellow). Here is my code:
import csv

from plotly.graph_objs import Scattergeo, Layout
from plotly import offline

filename = 'data/MODIS_C6_South_America_24h.csv'
with open(filename) as f:
    reader = csv.reader(f)
    header_row = next(reader)
    print(header_row)

    # Get latitudes, longitudes and brightness from this file.

    lats, lons, brights = [], [], []
    for row in


Q:

How to get an Enumerator[T] from List[T] when using Play 2 Iteratees

I am quite new to Play 2 and am trying Iteratees.
Q1. How can I get an Enumerator[Person] from List[Person]?
Q2. When I try to pass an Enumerator(Option[String]) to Ok.stream I get an error on console stating that

Cannot write an instance of Option[String] to HTTP response. Try to define a  Writeable[Option[String]]

Can someone point me in the right direction as to how I can define a Writeable for custom types to HTTP response?
Thanks.

A:

A1. You can use Enumerator#enumerate to run Iteratee for each Person
val persons: List[Person] = List(person0, person1)
Enumerator.enumerate(persons) |>>> Iteratee.foreach(println _)

https://github.com/playframework/Play20/blob/2.1.0/framework/src/iteratees/src/test/scala/play/api/libs/iteratee/EnumeratorsSpec.scala#L74-L83
A2. Instead of defining Writeable[Option[String]], extract String from Option[String]
Ok.stream(
   Enumerator(Option("kiki"), Option("foo"), Option("bar")).map(_.get) >>> Enumerator.eof
)

Nintendo aren't happy! Sure, they're making buckets of money from the Wii and DS, but shit, they could be making more. So starting this Christmas, the company will begin targeting the Latin American market more aggressively, with a Spanish-language marketing campaign and an emphasis on what Nintendo feel are the region's genres of choice: sports and fitness games. Sadly, no mention of Paper Pancho Bigotes, though we're sure Reggie's cracking that particular whip as we speak. Nintendo to boost drive in Latin American market [Reuters]


keyof Arrayish;
     ^?

type Mapish = { [k: string]: boolean };
type M = keyof Mapish;
     ^?
```

Note that in this example, `M` is `string | number` -- this is because JavaScript object keys are always coerced to a string, so `obj[0]` is always the same as `obj["0"]`.

`keyof` types become especially useful when combined with mapped types, which we'll learn more about later.

## Indexed Access Types

We can use `typeof` to reference the type of a property of a value.
What if we want to reference the type of a property of a type instead?

We can use an *indexed access type* to look up a specific property on another type:

```ts
type Person = { age: number, name: string, alive: boolean };
type A = Person["age"];
  name: "Alice", age: 15 },
    { name: "Bob", age: 23 },
    { name: "Eve", age: 38 }
];

type T = (typeof MyArray)[number];
     ^?
```


the future.

A Tipping Point?

Photo: RedAndr via Wikimedia, CC 3.0, CC 2.5

Stefan Rahmstorf, from the Potsdam Institute for Climate Impact Research in Germany, says that changes in the AMOC have lead to some of the most abrupt and powerful events in the recorded history of the globe’s climate. For example, the last Ice Age saw winter temperatures shift by around 10 degrees Celsius (50 degrees Fahrenheit). Rahmstorf is a distinguished oceanographer and took the lead on some of the recently published research. Rahmstorf draws attention to the volatility and unpredictability of the AMOC, saying that the system is in some ways “highly non-linear”, and that by fiddling with it you might cause some unpleasant surprises.

I wish I knew where this critical tipping point is, but that is unfortunately justwhat we don’t know. We should avoid disrupting the AMOC at all costs. It is one more reason why we should stop global warming as soon as possible.

If the AMOC were to collapse it would mean that western Europe would receive substantially less heat, potentially causing devastatingly severe winters in the region. A weakening of the AMOC has also been correlated with the collapse of ecosystems deep in the ocean. Yet though western Europe might freeze during the winter, it could also experience much hotter and more dangerous summers. The cooling of land near the north Atlantic wouldn’t happen immediately, it would take time for the northern waters to cool to the point where the land would be impacted. Yet the cooling would cause atmospheric currents to shift


- 2, -4*h - h = i*t - 220. What is the greatest common divisor of t and 180?
45
Let v be (4 - (2 + 0))*27/2. Suppose -v*c + 31*c = 48. Let z(h) = -h**3 + h**2 + 8*h - 3. Let g be z(3). Calculate the greatest common factor of g and c.
3
Let h be 892/(-3)*-198*27/648. Calculate the highest common divisor of 121 and h.
11
Let k be (30/45)/((-8)/30)*48/(-5). Suppose 0 = -3*i - 2*i + 20. Suppose -i*u = -1 - 23. Calculate the greatest common divisor of u and k.
6
Let u be 8 - 10 - (-7)/1. Suppose -9 = -g - u. Let h = 36 - g. What is the greatest common factor of h and 4?
4
Let f(l) = -41*l - 15*l**3 +15 and s?
3
Suppose 6*n - 64 = 2*n. Let y = 320 + -220. Let w = -76 + y. Calculate the highest common factor of n and w.
8
Let f(k) be the second derivative of k**3/2 + 19*k**2 - 11*k. Let l be f(-12). Let h be (4 + -7)*2/(-3). Calculate the highest common divisor of l and h.
2
Let b be (3/(-18)*40)/(1/(-12)). Let u(t) = -t**3 + 2. Let z be u(0). Suppose 0 = -z*s + 9 + 23. What is the highest common divisor of s and b?
16
Let a be 44/10 - 6/(-10). Suppose u + 5*y = y + 162, a*u = -2*y + 810. What is the highest common divisor of 108 and u?
54
Suppose -5*m + 21 + 144 = 0. What is the


do |paragraph|
  puts paragraph.chomp
  puts '-' * 40
  contents << paragraph.chomp
  paragraphs << paragraph.chomp
end

puts paragraphs[10]

This code gives me an array with all the paragraphs. I am using "\.\r" instead of "\n\n" because the texts are copied from PDF files, and have lost the normal page layout structures.
The next step is to save an array of the words in a paragraph into the array instead of simply a string of text:
words_in_each_paragraph = Array.new

File.foreach("Ann Reg Sci (2).txt", "\.\r") do |paragraph|
    word_hash = {}
    paragraph.split(/\W+/).each_with_object(word_hash) { |w, h|
        h[w] = []
    }
    words_in_each_paragraph << word_hash
end

puts words_in_each_paragraph[8]

Which gives the following output:
{""=>[], "The"=>[], "above"=>[], "contributions"=>[], "highlight"=>[], "the"=>[], "importance"=>[], "of"=>[],over $5,000.

The average resale ticket price for World Series games is over $1,000 for the second year in a row. In 2016, when the Chicago Cubs played the Cleveland Indians, average resale ticket prices were going for $4,578 when adjusted for inflation.

It’s reported by StubHub that for game 7 between the Dodgers and Astros, somebody purchased a pair of dugout club seats behind home plate for $117,000. StubHub also had two seats for that same game listed for $1 million each. No reports if there were any takers.

Which League’s Attendance Is on a Rise, Whose Is Falling?

On September 24, 2017, Donald Trump tweeted:

…NFL attendance and ratings are WAY DOWN. Boring games yes, but many stay away because they love our country. League should back U.S. — Donald J.


Click to share on Twitter (Opens in new window)

Click to share on Facebook (Opens in new window)

Married Matt Lauer Dating ‘Several Ladies’ After Sexual Harassment Scandal The disgraced host is ‘moving forward with his life’ amid divorce from longtime wife.

Matt Lauer’s sexual harassment allegations haven’t disrupted his dating life! The disgraced Today anchor has moved on from his estranged wife with a bevy of women following his NBC firing, RadarOnline.com can exclusively reveal.

“Matt is casually dating several ladies in the Hamptons,” sources told Radar. “As far as Matt is concerned, he had a consensual affair and he’s been punished. Now he’s moving forward with his life.”

The insider added, “Matt is still Matt.”

As Radar reported in October, Lauer has been “getting pretty serious” with a “blonde in her 20’swhat Yoffe says is a hands-free, eyes-free experience - similar to the digital assistants previously mentioned - where you can ask Vi to switch music, answer calls and more. Despite this, Vi won't understand or say everything in the human language. Instead, she's been restricted to certain patterns related to fitness.

"We're intentionally not going for free speech and natural free language interactions - we're going for commands for fitness designated experiences. Within the fitness, we have tons of dialogue that you can say.

"Here's an example of something she would say if your goal is to burn fat. We will pace you up or pace you down to get you within the most optimal heart rate training zone. Taking into consideration your environmental sensors, temperature, location, elevation and heart


sensitive and respectful towards what people are trying to achieve. This will be our main goal. Not to sell another piece of awesome hardware."

Vi is on Kickstarter now with an estimated ship date of December 2016.which came in 2017-18. Former non-league clubs Morecambe, who now play in the Football League and Wigan Athletic, now in League One are next with eleven wins. Morecambe's last victory coming in 2003–04 and Wigan's was in 1977–78.

Past winners
A full list of past winners -

Winners by club

References

External links
Official website of the Lancashire County Football Association

Category:Football in Lancashire
Category:County Cup competitions
Category:Recurring events established in 1885


the propelling force that is pushing you backwards.
The hint of an achievement tells you the way to get the highest jump :

Where Eagles Dare
Get the highest possible rocket jump using jump and crouch.
For the other question, the Rocket Jumper can be crafted with :

3 Mantreads, and 1 Reclaimed Metal
Soldier Token + Primary Token + Scrap Metal (1/8 possible results)
IRL money at Mann-Co Store, for around half a dollar

A:

You can Rocket Jump with a controller, it's just a lot trickier as you can't snap your view around like you can with a mouse.  Since rocket jumping involves aiming down while jumping, view snapping is a vital skill to it.
It's a lot easier to sticky jump with the demoman for this reason, aspoint the conversation should be moving along nicely. You're asking interesting questions and they're sharing something about themselves. How do you move the conversation around to something you want to share?

Before taking that step, build the relationship a little deeper by offering before you ask. What you offer doesn't have to be related to your business or organization. It can be a personal connection that you thought of as they were speaking. Perhaps you know a colleague they should meet, a great restaurant they should try or an organization they should check out.

You'll be seen as resourceful and a great connector. They'll want to hear what you have to say next.

5. Pitch. How do you want them to stay connected with you?

It should be clear by this point


think you're fascinating when the conversation ends and feel good about you when they see you next.

If you just launch right into your pitch in step 1, they'll likely avoid you next time and want to protect their friends from your aggressive pitch.

6. Exchange cards. Jot down what you discussed or a specific follow-up.

Ideally, you'll have 2-3 pockets so you can easily reach for your business card and keep track of the other cards you've collected - placing the ones you definitely want to follow up with separate from those that were just handed to you without any discussion.

Often professional clothing for women lacks pockets, so plan ahead and wear a jacket or sweater that does have pockets. Alternatively, place your business cards in a specific pocket ine between 1:39 PM and 1:51 PM?
12
How many minutes are there between 2:11 PM and 7:53 PM?
342
What is 690 minutes before 5:57 AM?
6:27 PM
What is 456 minutes before 9:38 PM?
2:02 PM
What is 296 minutes before 2:16 AM?
9:20 PM
How many minutes are there between 12:04 AM and 10:15 AM?
611
How many minutes are there between 7:56 PM and 12:07 AM?
251
How many minutes are there between 6:46 PM and 1:24 AM?
398
How many minutes are there between 9:15 AM and 11:37 AM?
142
How many minutes are there between 1:57 AM and 2:36 AM?
39
What is 547 minutes after 4:21 PM?
1:28 AM
What is 53 minutes before 1:18 AM?
12:25 AM
What is 296 minutes before 10:01 PM?
5:05 PM
What is 50 minutes before 5:12 AM?
4:22 AM
What is 406 minutes after 2:34 AM?
9:20 AM
What is 535 minutes after 4:10


AM?
492
What is 197 minutes before 1:09 AM?
9:52 PM
How many minutes are there between 12:21 PM and 10:46 PM?
625
What is 472 minutes after 8:45 AM?
4:37 PM
How many minutes are there between 9:08 PM and 7:35 AM?
627
How many minutes are there between 7:19 PM and 7:52 PM?
33
How many minutes are there between 7:08 PM and 5:13 AM?
605
What is 443 minutes after 2:12 AM?
9:35 AM
What is 625 minutes before 6:49 AM?
8:24 PM
What is 691 minutes after 1:42 AM?
1:13 PM
How many minutes are there between 1:14 PM and 11:24 PM?
610
How many minutes are there between 7:26 PM and 8:05 PM?
39
How many minutes are there between 8:17 AM and 8:23 AM?
6
What is 165 minutes after 3:39 PM?
6:24 PM
How many minutes are there between 5:25 AM and 2:41 PM?
556
How many minutes are there betweenSmartFunctor<Controller> callEndBlock(&controller, &Controller::endBlock);

  // Evaluate all expressions and set variables
  for (auto it = block->begin(); it != block->end(); it++) {
    (*it)->eval(*this);

    if ((assign = (*it)->instance<Assign>())) { // Handle Assigns
      Reference *ref;
      NamedReference *nameRef;

      if ((ref = assign->getReference()->instance<Reference>()))
        setReference(ref->getAddress(), assign->getExprValue());

      else if ((nameRef = assign->getReference()->instance<NamedReference>()))
        setReference(nameRef->getName(), assign->getExprValue());

      else THROW("Invalid reference type in Assign");

    } else if ((word = (*it)->instance<Word>())) { // Handle Words
      double value = word->getValue(); // Must be after eval