that confidence.”

Telstra Chief Executive Officer Andrew Penn released a statement thanking Ms McKenzie, who has been part of Telstra’s leadership team since 2007.

“Kate has been a positive force for Telstra, supporting four Chief Executive Officers and working to build our technology and innovation capability. She has been a significant contributor to our customer-focused culture and a role model for women in the organisation. I have appreciated her support and counsel,” Mr Penn said.

Telstra group executive global enterprise and services Brendon Riley will act as interim COO while the carrier conducts a international search for a replacement.

Ms McKenzie’s retirement marks the second high-profile Telstra executive to leave in the past few months.

Telstra’s chief technology officer Vish Nandlall left the carrier in May amid allegations his resume contained false information.Q:

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I tried the solution posted inall relevant parties to help determine whether we should move forward with this process and if so, how we should do it.”

Native Hawaiians have been taking steps to form their own government, but the possibility of federal recognition and a growing sense that many Hawaiians want to pursue independence led some observers to call for a delay in the nation-building process. Kamanaopono Crabbe, the CEO of the Office of Hawaiian Affairs, suggested a delay of at least six months after questions were raised about whether the Hawaiian kingdom still exists in the eyes of the United States.

“While a rulemaking process proposed by the DOI is designed to open the door to a government-to-government relationship between the United States and our people, we see this as only one option


the baby," said the friend, Giovanni Nieves.

But Nieves knew that Rosado was still using, buying both heroin and methadone on the street. He was also being treated for bipolar disorder.

When Nieves arrived the morning of May 11, 2012, a hysterical Rosado ran outside carrying his limp, discolored boy.

The baby had vomited into his bassinet, apparently as the drugs slowed and then stopped his breathing.

Rosado initially told police that he had no idea what happened, and admitted only in a third interview, after toxicology tests came back, that he had done eight bags of heroin after the boy's mother went to bed.

The mother, 29-year-old Crystal Miller, was also in a daily methadone program. She thought Rosado had been clean since their daughter's birth, she testified.

"Can you believe he triedNo state has a relationship remotely like the one between California and marijuana. We annually consume 2.5 million pounds of the drug and produce more than 13 million pounds of it.

Co-published by Fast Company

The summer mixers had not done the trick. Last year Oakland, California, which was launching the partnership component of its groundbreaking Cannabis Equity Assistance Program, found that City Hall meet-and-greets between the street-level victims of the war on drugs and those who had gotten rich by growing and supplying marijuana weren’t going to instantly result in legal-weed deal-making whoopee.

As part of California’s 2018 adult-use marijuana legalization, Oakland sets aside half of its marijuana business permits to grow, test, manufacture, transport, deliver and dispense pot for equity applicants — — newly up-from-the-underground residents who make up


a love connection. Gummi Cares offered Grant 1,000 square feet near the city’s airport to help get Herbin Collective off the ground. As business rentals in Oakland go for more than $50 per square foot, she was instantaneously with that plan.

“I wouldn’t mess with anyone else,” Grant told me over the phone. She focused on getting her delivery service in compliant, above-ground business for her March 1 launch. Meanwhile, AmeriCann would get to move its cultivation and processing operations ahead of those outfits that lack newly privileged partners such as theirs.

“The incentive was very high for the general applicants,” Gennino said, “because they want to get pushed to the top of the list.”

Speed bumps on this road to equality began popping up in February. While San Francisco was             $this->index();
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[Analysis of motility disturbances due to a combination of different orbital lesions by means of the synoptometer (author's transl)].
There is no clear cut symptomatology of the ocular motility in blow-out fractures. It is essentially dependant on the number of muscles involved, what muscle in particular and where the muscle in incarcerated. Besides the blow-out fracture an additional impairment of motility can occur, for example central nerve palsy or Brown's syndrome of traumatic origin. For the exact analysis of the deviation measurement from 10 to 10 degrees is essential which can best be achieved with the synoptometer of Cüppers.we are convinced that Coffman should not be permitted anywhere, in summary or plenary proceedings, to pursue his alleged set-off. Since there was ample evidence to support the Master's findings of Coffman's appropriations from Aircraft, and his debt to Aircraft arising therefrom, this was properly determined in the summary proceedings under Sec. 719 C.C.P. and the judgment of the trial court should have been affirmed.
We regret we were unable to convince our colleagues of the validity of this position. It is only because the case, as now decided, (and to which we heretofore gave our approval) represents a grave miscarriage of justice and permits Coffman to profit by his own wrong, that we feel called upon to state our present position on the courts' denial of the petition


a net worth of $20,190.51. Coffman was the dominant and controlling stockholder of Aircraft as well as its president, and had been such since January 17, 1945. Since that date and until 1949, he had been the person in charge of the affairs of Aircraft.

3
Within a matter of days after October 31, 1945, when Aircraft had a net worth of $20,190.51, Coffman began doing business as Nash Wilshire, an auto sales agency. On November 25, 1945, he opened a bank account under the name of Harry J. Coffman, doing business as Nash Wilshire. Having no funds of his own Coffman turned to the assets of Aircraft which he controlled and used these assets to establish himself in the Nash Wilshire venture.

4
From time to time Coffman drew money fromAircraft's funds. He maintained books, including a ledger with one account listing his indebtedness to Aircraft and a separate account with Aircraft entitled "Nash Wilshire" purportedly showing moneys due him from Aircraft. The first account gradually increased in amounts due Aircraft, reflecting moneys of Aircraft, utilized by Coffman. By May 31, 1947, the month the referee made his order in favor of Cobra against Aircraft, Coffman owed Aircraft $9,082.36 but the amount allegedy due Coffman on the Nash Wilshire account had been built up to $9,259.42.

5
By Coffman's own computations, as late as September 30, 1946, he was indebted to Aircraft in the sum of $9669.94 over and above his claimed offset. Thereafter by his same computation his indebtedness to Aircraft was cut down by the Nash Wilshire offsets


supplied.) In 1948 the same language was cited with approval in Abbot Kinney Co. v. Harrah, 84 Cal.App.2d 728, 191 P.2d 761. It is still the law, notwithstanding the revision resulting in the Corporations Code of 1947, supra.

18
"Directors are also trustees for the stockholders and indirectly for the creditors. * * * Directors and officers of corporations, as well as trustees, have always been held responsible for loss resulting from misappropriations of the trust property made by them or with their consent." Winchester v. Howard, 1902, 136 Cal. 432, 442, 443, 64 P. 692, 69 P. 77, 80. Saracco Tank & Welding Co. v. Platz, 1944, 65 Cal.App.2d 306, at page 315, 150 P.2d 918, involved a foreign corporation but quoted with approval from the Winchester case, supra.the directions parallel to the edges of the cube having for vertices the four ones of the tetrahedron plus the four ones got by reflection of these latter through the center. (b) There are six absolute maximal radius circumscribed cylinders to the regular tetrahedron. The ratio of the maximal radius to the length of the edge is $3\sqrt{2}/8$. The axis of the six cylinders following the directions parallel to the edges of the tetrahedron*. 0.5cm

*Proof.* We use: $x_1'=(1,1,1)$, $x_2'=(1,-1,-1)$, $x_3'=(1,-1,1)$, $x_4'=(-1,-1,1)$.

Part (a): the center is at the origin and the covariance matrix $V$ is the identity matrix $I$. The squared radius to be minimized is $\rho^2=Tr(V)-u'Vu+c'c=2+c'c$, under the constraints $u'c=0$ and $u'u=1$, with $\gamma=2c=T^{-1}X'b$. The absolute minimum at $c=0$ and $\rho^2=2$ will be valid under the condition that


non null vector $u$ got during the Newton iterations can be renormalized without affecting the convergence of the iterative process. Such technique was successfully used in a minimal variance computation encountered in the geometric docking problem [@Petitjean2002; @Petitjean2004]. Some other practical implementation details follow. Random starting unit vectors are generated from an isotropic distribution. At the iteration $k$, the Lagrangians values are computed to minimize the norm of the full gradient of $F$. Then the Newton step $s_k=-\alpha_k H_k^{-1} g_k$ is computed, where $g_k$ and $H_k$ are respectively the gradient of $F$ at $u_k$ and its Hessian at $u_k$, and $\alpha_k$ is a positive real, which is usually set to $1$ when the quadratic convergence is achieved (see also the discussion at the end of the paper). Howeveras mentioned above, the normalization constraint is restored via setting $\Vert u_{k+1}\Vert=1$.

Our implementation of the solver was programmed in f77 with double precision (i.e. 64 bits) floating numbers. The termination criterion was $\vert cos(u,c)\vert\le 10^{-10}$ and $\vert (F_{k+1}-F_k)\vert/(F_{k+1}+F_k) \le 10^{-10}$. Alternate termination criterions may consider the norm of the gradient, the norm of the Newton step $s$, etc.

Thousands of random tetrahedra were generated from various probability laws, including quasi-flat and quasi-linear sets. The implementation of the Newton method appeared to be effective for most random initial unit vectors. In fact, for most tetrahedra, the convergence was observed for all initial vectors. In the worst situations, reducing significantly the length of the Newton step at each iteration before restoring the orthogonality constraint and operating with 100-250 initial values suffice


because the 5 first ones are dependant (sum to zero). Again, the radius is computed from $c$ and $u$ and the center $c=\gamma/2$ is computed according to (5):

0.5cm $\rho^2=\bar{\Delta}=Tr(V)-u'Vu+c'c$

$\gamma=T^{-1}X'b$, 0.2cm $b_i=u'B_iu$ 0.5cm 0.5cm

Thus, reporting the expression of $c$ in some linear combination $t$ of the 5 first equations of (8) lead to a system of only 3 equations of 3 unknowns, i.e. the components of $u$. We define the vector $\mathbf{1}$ as a vector having its 5 components equal to 1. $X$ being centered and of full rank, there is only one direction orthogonal to the $4$-dimensional subspace defined by the the three independant columns of $X$ and the vector $\mathbf{1}$, this latter being itself orthogonal to each of the 3 columns of $X$, i.e. $X'\mathbf{1}=0$. We set- \frac{\mu_1+\mu_3}{2\sqrt{-\mu_1\mu_3}}$ (11)

0.5cm 0.5cm

Reporting $u_3/u_1$ in the expression of the cubic curve in the projective plane leads to a polynomial of degree six in $u_2/u_1$, which has at most 6 real roots. We deduce $u_3/u_1$ from (11) and then we have the direction of $u$. So we get at most 6 cylinders.

The existence of solutions such that $u_1=0$ should be checked. When $\mu_2\ne 0$, we deduce from (10) that $u_2=0$, and hence $u'=(0,0,\pm 1)$ should satisfy to $u'\gamma=0$, so that the coefficient of $u_3^3$ in the cubic form is null. If the solution $u'=(0,0,\pm 1)$ is indeed found, the other ones found in the projective plane from (11) are such that the curve defined from $u'\gamma=0$ degenerates to a quintic of $u_2/u_1$ and we cannot expect more than


$\mu_3\ne 0$. When $\mu_1\ne 0$, $u'\gamma$ is an homogeneous cubic of $u_2$ and $u_3$ which offers at most 3 roots when solved either in $u_2/u_3$ or $u_3/u_2$ ($u_2$ and $u_3$ cannot be both null), so that we expect at most 3 cylinders. A similar conclusion is got when $\mu_3\ne 0$.

In any case, the system (9) can be solved by finding the roots of a polynomial of degree at most 6, and we cannot get more than 6 cylinders, which redemonstrates lemma 1.

**6. An example of trigonal bipyramid with a symmetry axis of order 3** 0.5cm 0.5cm

We present the case of a bipyramid $\cal{BP}$ symmetric around its equilateral triangular basis with a symmetry axis of order 3 orthogonal to the triangular basis. We set $x_1'=(0,0,h)$, $x_2'=(0,0,-h)$, $x_3'=(1,0,0)$, $x_4'=(-1/2,\sqrt{3}/2,0)$, $x_5'=(-1/2,-\sqrt{3}/2,0)$.references at the appropriate places. Since these results are obtained here via different techniques and add both to the clarity and the self-content character of the paper, we left them. Having said that, we recall that several novelties are introduced in this paper. First, formulating the problems through variance minimizations led us in the three-dimensional case to the original systems (6) and (9), which offer particularly simple expressions of the unknown axis $u$. It means that iterative numeric solvers need only random $3$-tuples, and can be programmed by most users having some knowledge of constrained optimization, without needing to install specialized mathematical packages.

In the case of the circumscribed cylinder to five points, we produced a simple and new condition of existence of the cylinder relying on the eigenvalues


and T. Theobald, Radii minimal projections of polytopes and constrained optimization of symmetric polynomials. *Adv. Geom.* **6**, 71-83 (2006).

O. Devillers, B. Mourrain, F.P. Preparata, and P. Trebuchet, Circular cylinders through four or five points in space. *Discrete Comput. Geom.* **29**, 83-104 (2003).

H. Edelsbrunner, Constructing convex hulls, in *Algorithms in combinatorial geometry*, chap. 8, pp. 139-176. Springer-Verlag, Berlin, 1987.

A. Eigenwillig, L. Kettner, W. Krandick, K.Mehlhorn, S. Schmitt and N. Wolpert, A Descartes algorithm for polynomials with bit-stream coefficients, in *Computer Algebra in Scientific Computing: 8$^{th}$ International Workshop, CASC 2005*, Kalamata, Greece, *LNCS*, **3718**, 138-149 (2005).

P.E. Gill, W. Murray, and M.H. Wright, Non linear constraints, in *Practical Optimization*, pp. 205-260. JAI Press, Emerald Group Publishing Ltd., London, 2008.

H. Maehara, On congruent embeddings of a tetrahedron into a circular cylinder. *Yokohamalenalidomide and weekly dexamethasone was further evaluated in a phase 3 RCT with lenalidomide and dexamethasone as the control group \[[@B19]\]. The results of this trial indicated that the triplet regimen is better than lenalidomide and dexamethasone alone in terms of PFS. Carfilzomib is a recently developed epoxyketone PI. Carfilzomib exerts significant antimyeloma effect through selectively and irreversibly binding to constitutive proteasome and immunoproteasomes \[[@B27]\]. In a phase 1 and 2 study, carfilzomib, lenalidomide, and low dose dexamethasone combination therapy showed activity in patients with relapsed disease \[[@B28], [@B29]\]. Recently, a phase 3 RCT comparing lenalidomide and low dose dexamethasone with or without carfilzomibd in relapsed MM patients was completed. The results of this trial also indicated that the triplet regimen is better than lenalidomide and dexamethasone alone


dynamics modelling approach. System dynamics, or SD, applies the modern theory of nonlinear dynamics and personal construct theory to solve problems based on the dynamic behaviour observed in complex systems \[[@pone.0189878.ref019],[@pone.0189878.ref020]\]. An important aspect of SD models is the concept of feedback in which shocks (as well as planned changes in practices, policies, etc) to a system can have dynamic, unanticipated consequences on system behaviour. We describe feedback as interactions among components of the system and how they reinforce or self-correct system behaviour \[[@pone.0189878.ref019]\]. Through model building, these feedback structures can be identified and quantified, which allows practitioners to observe the influence of specific drivers in a system.

In an animal health context, and particularly in the context of ECF in Zambia, it is important to recognise that theawareness, education, or specific socio-economic policies).

SD models can be developed using participatory processes, which improves their accessibility and internal validity \[[@pone.0189878.ref020]\]. In this study, we used a recent innovation in participatory processes called spatial group model building (SGMB) \[[@pone.0189878.ref022]\]. SGMB uses geographical information system (GIS) concepts and techniques that allow capturing stakeholders to identify the spatial phenomenon directly on physical maps and describe how the phenomenon interact in the form of qualitative SD models. SGMB improves the quality of information received from stakeholders and grounds it spatially by providing more targeted details on the "where" (i.e., the location) of problems in question. For diseases like ECF, the setting of the system, including the location of farms, socio-economic characteristics of farmers, the location of veterinary information, movement patterns of


\[[@pone.0189878.ref021]\]. System dynamics models can either be qualitative or quantitative. Quantitative models employ computer simulation on a parameterised model to test hypotheses about the relationships between the system structure and system behaviour \[[@pone.0189878.ref024]\]. Quantitative SD models are systems of nonlinear differential equations that specify behaviour and relationships in complex systems \[[@pone.0189878.ref025]\]. However, rather than representing such mathematical complexity through programming code, SD uses graphical features to intuitively represent these mathematical formalisations that are defined in the background, which allows for easier of communication with and use by non-technical audiences. In a qualitative analysis, the focus is on the structure of the system and to identify the feedback effects that could drive system behaviour over time. This paper focuses on the qualitative and diagramming aspects of the approach.

The languagegatekeeper was a former student of the University of Zambia who originally comes from there and was working at the District Veterinary Office. In Lundazi district, the gatekeeper was a Veterinary Assistant who worked at the District Veterinary Office for more than five years. We initially used both gatekeepers as enumerators during a baseline survey. Constant engagement through phone call meetings with gatekeepers and their assistants helped to make the preparation a success. The modelling team also had two brief meetings to rehearse the SGMB process. The modelling team was made up of four members; a senior SD modeller, a junior SD modeller, a rapporteur, and a gatekeeper. Other researchers have recommended larger modelling teams in GMB \[[@pone.0189878.ref037]\], but the lack of available expertise constrained us with the


3.2.2 Household socio-economic model {#sec024}

From the SGMB sessions, we overlaid the epidemiology of ECF alongside socio-economic considerations. We considered socio-economic issues through constructing a simple model of household cash flow and asset accumulation. Households are assumed to have a stock of cash whose level at any period of time depends on inflows of income and outflows of expenditures. The sources of income (determinants of income generation rate) for traditional cattle farmers were crop sales, cattle sales, relatives and other activities. Cash is mainly spent on school fees for children, household necessities, farm input for crop production, and other needs. While not explicitly highlighted in the conceptual SD model, both income and expenditures are both spatially and seasonally determined as noted in the discussion in section 3.1. In particular,can retransmit the corresponding data at the physical layer. The receiver may combine the retransmitted data with the previously received data for which decoding has failed, increasing data reception performance. When the data is correctly decoded, the receiver may send information (ACK) indicating successful decoding to the transmitter so that the transmitter can transmit new data.
FIG. 1 illustrates a basic structure of the time-frequency domain in the downlink of the LTE system serving as radio resources for transmitting data or control channels.
In FIG. 1, the horizontal axis denotes the time domain and the vertical axis denotes the frequency domain. In the time domain, the minimum unit for transmission is OFDMA symbols, Nsymb OFDMA symbols 102 constitute one slot 106, and two slots constitute one subframe 105. The length


command sits in the left seat," Haris recalled.

But it began the training for one of the biggest challenges of his life, the teen said.

Haris dedicated hundreds of hours to his training, juggling flying with his science-heavy course load at Plainfield High School and SAT preparation. He said flying has taught him to be more prepared and analytical.

"Becoming a pilot is one of the hardest things someone can do, to be honest," he said. "It's taught me to be more proactive: I need all my paperwork, I need all my thoughts in process before I leave. It's helped me a lot for the better."

The trip also gives the Sulemans an opportunity to raise money for Seeds of Learning, a nonprofit that supports early education initiatives in Pakistan. They raisedclub would take part in the FA Cup and FA Vase for the first time in the club's history, falling at the first hurdle against Leighton Town in the FA Cup, whilst reaching the second round in the FA Vase.

Season-by-season record

Current staff

Honours
Hellenic League
Supplementary Cup Winners 2018–19
Gloucestershire County League
Champions 2009–10, 2017–18
Les James League Cup Winners 2014–15, 2017–18
Bristol Premier Combination
Premier Division Champions 1956–57, 2001–02
Division Two Champions 1965–66
Bristol & District League
Division Three Champions 1949–50
Harry Greening Memorial Trophy
Winners 2003–04

Records

Highest League Position – 3rd Hellenic League Division 1 West (2018-19)
 Record Attendance – 395 vs. Newent Town (22 April 2019)
Best FA Cup Performance – Extra Preliminary Round (2019-20)
Best FA Vase Performance – Second Round Proper (2019-20)

References

External links

Category:Football clubs in England
Category:Football clubs in Gloucestershire
Category:1898 establishments in England
Category:Association football clubs established in 1898
Category:Bristol and District Football League
Category:Bristol Premier Combination
Category:Gloucestershire


obviously [makes] a difficult situation even more difficult, when government has mandated that employers must try to extract a three-and-a-half per cent cut," said Hubich.

"It's really unfair to the workers who didn't create the mess in the first place."

Hubich suggested the government could instead cut costs by renegotiating its contract for building the $1.9-billion Regina bypass project, or asking for concessions on private sector contracts for projects like hospitals and schools being built under public-private partnerships.

'Wall's Weekends' among measures considered

Wall said the 3.5 per cent target will be acknowledged in the government's upcoming budget, which will be tabled on March 22.

Wall would not say what the government planned to do if unions refused to meet the target.

The government would also be looking at inefficiencies in overtime processes andto be eligible to become a Cirrus Chain Federated member.

Cirrus Chain Multi-Sig Masternode

Similar to a Cirrus Chain Federated Masternode, a Multi-Sig Masternode can also produce blocks on the Cirrus Chain. In addition, these Masternodes form the multi-signature address that secures the chain.

There is a 50,000 STRAT collateral requirement in place to be eligible to become a Cirrus Chain Multi-Sig MasterNode.

The number of Masternodes that can operate on the Cirrus sidechain is currently limited to 101 members to ensure a level of decentralization as multiple entities will be producing blocks on the chain. We will soon release dynamic federation membership allowing nodes to join and/or leave the Federation, further increasing the decentralisation of the Cirrus chain and allowing additional nodes.

The collateral amount for both Masternodes will need to be


sent at the time of shipment (be aware of your SPAM email box).

Deliveries in Portugal are held on the business day following the expedition.

All shipments have loss insurance (check deadlines for the selected shipping type).

Prices shown include VAT at the rate in force. The discounts indicated are valid until 31 December of the present year, except for stock breach or campaigns specifically created and disclosed for short periods of time.to the 0, 50 and 100 IU HCG single injections. Administration of 500 and 250 IU HCG for 2 days of estrus resulted in a greater percent ovulation rate than the 2-day injection of 50 IU (p less than 0.05). These results indicate that the proportion of mature follicles ovulating in an induced ovulator, such as the cat, is an increasing function of graded dosages of exogenous hormone.


Ntshangase

Ntshangase is a South African surname that may refer to
Luyanda Ntshangase (1997–2018), South African footballer player
Phumlani Ntshangase (born 1994), South African football midfielder
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   go to trial this summer.

The officer's first known near-killing of an unarmed citizen occurred 17 years earlier, and was the subject of an award-winning Metro Times cover story, "Under the Gun." In that incident, Blanding repeatedly shot a man who said he'd mistakenly walked up to the officer's vehicle at a drive-up ATM.

According to court records referenced in the report, trouble with the cash machine had compelled the victim, Johnny Crenshaw, to get out of his girlfriend's minivan to get help from a woman using another ATM. While Crenshaw was out of the minivan, his girlfriend moved to let in another SUV being driven by Blanding, who was off-duty at the time.

As the victim fussed with his cash, card, and wallet, he said he walked back to the


wrongdoing by Officer Blanding, a longtime member of the Detroit Police Department.In January, while Blanding was on restricted duty and not to be carrying a gun due to last year's killing, the prosecutor's office says Detroit police found him at the scene of a car crash smelling like booze, slurring his words, and illegally carrying three guns. As officers tried to render aid to the the person hurt in the crash, the prosecutor's office says he resisted and obstructed their efforts. Blanding was off duty at the time and apparently knew the accident victim, though the prosecutor's office says he was not involved in the crash.Blanding is charged with three counts of possession of firearm while under the influence, eight counts of resisting and obstructing the police, andsix counts of felony firearm. He was arraigned this afternoon in 36th District Court.Police Chief James Craig intends to request Blanding be suspended without pay, a spokeswoman for the Detroit Police Department said. He is currently suspended with pay.It's not clear why Blanding was still on restricted duty almost a full year after the fatal shooting and weeks after he had been cleared of any wrongdoing in the case. Officers involved in fatal shootings are routinely placed on "disabled" restrictive duty, though how long that lasts is up to the department."Every officer involved shooting, our officers go through an evaluation with a doctor, Craig said in a news conference Wednesday. "Part of the role that we play is that we make an evaluation as well and there are


to implement its PCR at ever more impressive scales (in terms of individual size and aggregate number of reaction centres) and performance levels, this step remains a critical impediment to visions of ubiquitous, low-cost sequencing platforms given the relatively sophisticated chemical preparation and control it requires. Arguably, an even more immediate drawback to the reliance of NGS systems on clonal amplification is the compromised diagnostic ability of the sequencer. This stems simply from the errors incurred during the amplification procedure's copy process and its inability to retain molecular variants, such as methylation, a critical marker for the study of epigenetic phenomena. The ability of nanopore methods to sequence without resorting to chemical amplification has the potential to avoid this problem \[[@B11-biosensors-06-00042],[@B12-biosensors-06-00042],[@B13-biosensors-06-00042]\].

Another limitation of NGS systems is their relativelyoperate on multiple copies of that molecule; the latter deficiency is essentially mitigated by the introduction of a short-memory (ideally zero-memory) detection scheme.

Nanopore-based sequencers are one embodiment of this vision, and we detail them and their interface to CMOS technologies below. In the spirit of establishing a broader context, however, we first outline its contemporary on the single-molecule sequencing front, Pacific Bioscience's (PacBio) focused optical detection system \[[@B23-biosensors-06-00042]\]. In this technology, a nanoscale well (100-nm in diameter) with a special coating has a modified DNAP adhered to its bottom. The minuscule well structure achieves accurate focusing of light, a zero-mode waveguide (ZMW), capable of directing light originating from close proximity to the DNAP to an optical detection system \[[@B24-biosensors-06-00042]\].

As with optical NGS schemes, the PacBio system has its


A). This separation effectively defines the signal, $i_{\delta}$ (and its strength), and is significantly higher than currently-reported BN values. Another useful signal metric is the full-scale modulation depth $\Delta I = \max\left( \left\{ \Delta I_{x} \right\} - \left\{ \Delta I_{x} \right\} \right)$ a value that, again, can reach substantially larger quantities in SSNs than BNs.

The terms above are critical in determining the design of the CMOS interface. Clearly, $\Delta G_{x}$ influences the size of the signal that our CMOS interface needs to process. Given their common origin (i.e., as attested by a comparison of Equations ([5](#FD5-biosensors-06-00042){ref-type="disp-formula"}) and ([6](#FD6-biosensors-06-00042){ref-type="disp-formula"})), $G_{dc}$ is also an indication of the achievable signal strength, with higher values of $G_{dc}$ implying the availability of larger signal currents.

For BNs, it is not uncommon to operate withminimize $C_{m}$ in order to maximize the high-frequency handling ability of the sensor.

The more intricate structure of SSNs provides for more capacitive contributors \[[@B63-biosensors-06-00042]\], but arguably the most important of these is the portion of nitride material exposed to the chemical bath on both sides. This layer, roughly 50-nm thick, possesses a capacitance of roughly 1.2 fF/${\mathsf{\mu}m}^{2}$ \[[@B63-biosensors-06-00042]\], smaller than the 10 fF/${\mathsf{\mu}m}^{2}$ of the thinned nitride layer, but typically distributed over a much larger area.

Alongside the pore's own membrane capacitance, ancillary contributions (e.g., wiring, package, circuit, etc.) due to the details of the connection between the sensor and its electronics give rise to the interface capacitance, $C_{i}$. In work relying on standard nanopore/electronics interfaces (discussed in [Section 4](#sec4-biosensors-06-00042){ref-type="sec"}), this value could easily reach values of 20 pF


to mix the chemicals and their flow rates. Droplet diameters ranging between 5 and 500 $\mathsf{\mu}$m are readily achievable, with diameters as small as 100-nm anticipated \[[@B75-biosensors-06-00042]\]. Adjacent droplets form bilayer membranes between one another, an outcome that can be extended to the formation of a layer between a droplet and a planar aqueous surface \[[@B76-biosensors-06-00042]\]. The amphiphatic molecules surrounding each droplet also stabilize them, preventing merging and, hence, a much more consistent droplet size.

An arrangement such as that shown in [Figure 15](#biosensors-06-00042-f015){ref-type="fig"} (showing one micro-well of an array) can be realized by constructing the droplet emulsion discussed above and allowing it to flow over a micro-well array built atop a CMOS chip. During this process, droplets are deposited in the like-sized wells, the rest of which isHz.

Fortunately, CMOS affords the realization of an active (i.e., transistor-based), $R_{f}$, as demonstrated by the circuit shown in [Figure 23](#biosensors-06-00042-f023){ref-type="fig"} \[[@B86-biosensors-06-00042]\]. Herein, a reference resistor $R_{r}$ orders of magnitude smaller is used to establish a current, which undergoes a compressive current-to-voltage-to-current transformation via the transistors $M_{1}$ and $M_{2}$. As a result the current through the circuit is linearly attenuated depending on the ratio of the transistor sizes leading to the linear relationship $R_{f} = M \cdot R_{r}$, where *M* can easily be made in excess of 100.

The active implementation of $R_{f}$ is much smaller with negligible capacitive parasitics compared to its passive on-chip counterpart.

Alas, for nanopore applications, the active $R_{f}$ remedy is not sufficient. The combination of a large $R_{f}$ and a potentially large net membrane/interface capacitance $C_{t}$


       Plaintiff and Respondent,

         v.                                                         (Super. Ct. No. FWV1102700)

ISABEL ROSAS et al.,

         Defendants and Appellants.

         APPEALS from judgments of the Superior Court of San Bernardino County,

Shahla S. Sabet, Judge. Both judgments affirmed in part and reversed in part.

                                2
because the police failed to advise her of her Miranda2 rights before she made her self-

incriminating statements. Relying on her own statements to the police that she told

Varela and others not to hurt Cate, Rosas also contends her conviction of assault by

means of force likely to produce great bodily injury must be reversed because there is no

evidence she intended to aid and abet the assault upon Cate.

       In addition, defendants contend (1) the sentence imposed for their kidnapping

convictions should be stayed under section 654 because the prosecution's theory of first

degree murder was felony murder


other men drove to a liquor store

where Varela purchased some things, and then they drove to Montclair Plaza. Varela told

the men they would have to wait there until Rosas called or texted them to return to

Legends. Varela told them Rosas was going to tell Cate to give her the Buick and that if

he did not do so, Varela and and the other men would take the car by force. Varela also

said Rosas wanted them to beat up Cate, take him to Tijuana, and leave him there so he

could not come back because he did not have any "papers."

       At around 12:31 a.m. on October 5, 2011, Rosas contacted Varela by phone.5

Varela then told the men, "It's time. Let's go," and the group      10
       Varela also told Detective Potts that Rosas provided the men with pieces of green

rope to tie up Cate and that he and Rosas went over the plan in the Legends parking lot.

Rosas told him she would park the Buick in the darkest place in the parking lot, and

Varela and the other men were to approach Cate, "take him down," and tie him up.

Varela also said Rosas had "staged" the crimes so she would look like a kidnapping

victim. When Varela got in the back seat with Pizana and Cate, he told Cate in

accordance with Rosas's instructions that Sanchez's father had sent him and that he (Cate)

was to stay away from Sanchez. Varela told Detective Potts that


any time during the interview, and she

was free to leave at any time. Detective Duran spoke to her in Spanish during the entirety

of this first of four recorded interviews.

       On October 13, 2011, the date of the second interview, Detective Duran picked

Rosas up at her home and drove her to the Upland Police Department where Detective

Potts interviewed her in an interview room with Detective Duran acting as the translator.

The detectives went over the statements Rosas gave the previous day. Detective Duran

testified he still believed during this entire interview that Rosas was a kidnapping victim,

and he took pictures of her because of this. Rosas was not advised of her Miranda rights

during the 59-minute interview. She was not handcuffed, the door was not locked,                                   20
       The court also ruled that Rosas's statements were voluntary. The court specifically

found that Rosas "was under no duress except constant barrage of facing her with her

inconsistencies and asking [her] to tell the truth."

       Rosas's counsel argued that when Detective Potts sent Detective Duran to pick her

up, "a reasonable person could look at that as a demarcation point between voluntariness

and involuntariness." Counsel asserted Rosas was not treated like a victim. Counsel also

asserted that while the police provided basic "accoutrements of voluntariness,"


wants this

guy [(Cate)] to get beat up" and she wanted Varela to take him to Tijuana and drop him

off because he did not "have papers to come back."

       The prosecution's evidence regarding Rosas's conduct during the assault also

supports the jury's finding that she intended that Varela and his cohorts assault Cate.

Garcia testified that Pizana opened a back passenger seat door of the Buick and Rosas got

out. Pizana then entered the back seat and repeatedly punched Cate in the back. Varela,

Tafich, Garcia and David then joined Pizana in punching Cate. Oscar testified that the

doors of the Buick were open during the assault and Rosas was "[j]ust standing there"

watching what was happening inside the car as it rocked back and forth. Rosas said

nothing duringtags did not affect the function of the wild-type *ERB1* gene; growth and pre-rRNA processing resembled that of a strain expressing untagged Erb1 from its endogenous promoter ([Supplementary Figure S4](#sup1){ref-type="supplementary-material"}).

Deletions within the relatively less conserved N-terminal 150 amino acids of Erb1 (*erb1Δ3-50, erb1Δ51-100* and *erb1Δ101-160*) did not affect growth or pre-rRNA processing when NLS-containing *erb1* fusion constructs were used ([Supplementary Figure S5](#sup1){ref-type="supplementary-material"} and data not shown). However, deletion mutant *erb1Δ51--100* lacking a fused NLS (*GFP-erb1Δ51--100*) failed to grow in glucose, suggesting that this region might be required for nuclear localization of Erb1 ([Supplementary Figure S5](#sup1){ref-type="supplementary-material"}). In contrast, the *erb1Δ161--200, erb1Δ201--245, erb1Δ246--310, erb1Δ311--365* and *erb1Δ366--419* mutants failed to grow either in the presence or the absence of an NLS (Figure [1D](#F1){ref-type="fig"} and [Supplementary Figure S5](#sup1){ref-type="supplementary-material"}). Thus, we focused on these


regain his strength. He also has super hearing, which allows him to respond to anyone who calls his name out in distress, anywhere in the world.

 (1988-2019), Kōichi Yamadera (2019–present)
 The creator of Anpanman and a very kind baker. He is a skilled cook with knowledge of nearly everything in the world.

 Assistant to Uncle Jam. She is dedicated and hard working, but prone to forgetting things. Her name literally translates to, "Butter Girl." She makes and mends the capes of Anpanman and the other heroes appears in the story.

 A dog that lives in Uncle Jam's bakery. In the manga, he became Anpanman's loyal friend after he saved his life. In the anime, a young Anpanman finds Cheese starving during his very first patrol, and gives aթեման:
Ես խոսեցի աշխարհը գունավորելու մեր
բաց թողած հնարավորության մասին:
Նախքան բեմ դուրս գալս, մի քանի րոպե
կանգնած էի կուլիսներում,
ու ինչքան մոտենում էր իմ բեմ դուրս գալու հերթը,
այդքան տագնապս ավելանում էր,
այնքան էի հուզված, որ արդեն մոռացել էի,
թե ինչ եմ խոսելու:
Եվ մտածեցի. <<Հաղորդավարը թող խոսի,
ներկայացնի, իսկ երբ ինձ կկանչի բեմ,
ես էլ այտեղ չեմ լինի:
Հա, հենց ըտպէս էլ կենեմ,
կարևորը փախնիմ ստեղից ինչքան հնարավոր է հեռու>>:

English:
(Applause)
After making this plan, I raised
my head to leave and...
The host was looking at me
and calling me to go on the stage.
So I had to do that.
I took the microphone,
smiled, and started.
But I don’t even remember what I said.
I only remember talking so fast,
trying say all the things
I had in my mind.
When that one minute was up,
I was very satisfied with what I did,
and wanted to go


շատ ստացված էր,
ու որ ես շատ անկեղծ էի:
Այստեղ հասկացա, որ խոսքս,
թեկուզ մեկ րոպեիվա խոսքս հասել է հանդիսատեսին,
և որ իմ ստացված ելույթի գրավականը
անկեղծությունն է:

English:
Well, I am not as experienced
as some skillful speakers,
but they argue that honesty
is important in public speaking.
We all know TV and radio host, Larry King.
Once he said, “Speaking
is the most important joy in my life.”
How do you think he started
his joyful career?
The first day in radio,
he could not talk at all
as it felt to him that his mouth
was full of cotton.
Instead of his voice,
people could hear only music,
but its volume
rose and fell several times.
This went on until the director
opened the door and shouted,
“Here you need to talk!”
Larry King then concentrated,
and started talking.
He was honest with everybody.
People liked it and accepted him.
Once heհեռուստադիտողին, թե ինչ էր
կատարվում իր հետ այդ մի քանի րոպեի ընթացքում:
Եվ ընդունվում է հանդիսատեսի կողմից:
Իսկ Սթիվ Ջոբսը, բոլորս էլ ճանաչում ենք,
նա իր խոսքի ընթացքում պահպանում է
մի քանի հստակ արտահայտված կանոններ՝
խոսքը ժեստերով, բաց դիրքերը,
կապը հանդիսատեսի հետ և անկեղծությունը:
Սա Լարի Քինգը, Սթիվ Ջոբսը և ես:
Բայց շատերի համար հանրության առաջ
հանդես գալը համարվում է վախ:
Սա սոցիալական ամենատարածված վախերից մեկն է,
մահվան հանդեպ վախից հետո՝ երկրորդը:
Հոգեբանների պնդմամբ, այս՝ հանրության առաջ
հանդես գալու վախը ծագում է մեր մոտ դեռ մանուկ հասակից,
երբ մեր ծնողները փակում են մեր բերանները.
>,
>,

English:
and he was spinning on the chair
for many times, it was very funny.
Then he honestly said
what he felt during those minutes,
and again, people liked that honesty.
What about Steve Jobs?
He had some unique talent
for public speaking:
hands in open positions,
eye contact, gestures,
and of course honesty.
This is what I had to


Al W. Patton

Al W. Patton (born September 18, 1937) is an American politician in the state of Minnesota. He served in the Minnesota House of Representatives.

References

Category:1937 births
Category:Living people
Category:Minnesota Democrats
Category:Members of the Minnesota House of Representativeswife as part of the program. Amrhein agreed.

Because Amrhein and Hoffman refuse to answer questions, it is not known if Amrhein or his wife paid to be part of the program. Nor is it known if they reimbursed Pure North for flying a nurse to Edmonton specifically to take their blood.

Ethics commissioner Marguerite Trussler told CBC News last month that when Amrhein became deputy minister, he disclosed to her office that he was a participant in Pure North's alternative health program.

She refused to say whether Amrhein had disclosed anything more about his relationship with the health foundation, saying she could only legally reveal what Amrhein had given her permission to disclose.

Trussler said she questioned Amrhein about his signing of the October 2016 grant. She said Amrhein told her


Altered amplitude of low-frequency fluctuation in primary open-angle glaucoma: a resting-state FMRI study.
To analyze the altered amplitude of low-frequency fluctuation (ALFF) of the brain using resting-state functional magnetic resonance imaging (fMRI) in patients with primary open-angle glaucoma (POAG). Resting-state fMRI was conducted in 21 POAG patients and 22 age-matched healthy control subjects. After the ALFF and fractional amplitude of low-frequency fluctuation (fALFF) for slow 4 and slow 5 bands were calculated, the results between POAG patients and healthy controls were compared. Then the correlations between ALFF/fALFF values and the disease stage of POAG were analyzed. Compared with controls, POAG patients showed significantly decreased ALFF/fALFF values in the visual cortices, posterior regions of the default-mode network (DMN), and motor and sensory cortices. Meanwhile, ALFF/fALFF values in the prefrontal cortex,...it's so EASY and SO useful. It's accessible. You feel the friendship of the developer with every detail so thoughtful addressed. TourMake is a BRIGHT LIGHT in the world today. We at Studio Sophos look forward to a very bright and happy New Year. Thank you, TourMake for making our lives so much more interesting as you help us share our world and experience the world around us. This is the real deal.

Theresa Jensen

Maine Virtual Tours -USA of Tourmake's capability of working both with Google Business View and Views, and the display of hotspot panels and tour navigation is clean and very professional looking.

Joel Bolton

Tourmaker will enable my clients to fully integrate and manage functionality of their business view tours enabling a tailored experience for their business and


point in the game.
The corollary to this behavior is that in a game N situation (or game N-1 if you're losing floor(N/2) to floor(N/2)-1), losing players will often stay longer as defeat implies elimination.

he won second place in 2007 for editorial writing from the Inland Press Association, the nation's oldest national journalism association of nearly 900 newspapers as members. At CommonWealth, Jack and editor Bruce Mohl won first place for In-Depth Reporting from the Association of Capitol Reporters and Editors for a look at special education funding in Massachusetts. The same organization also awarded first place to a unique collaboration between WFXT-TV (FOX25) and CommonWealth for a series of stories on the Boston Redevelopment Authority and city employees getting affordable housing units, written by Jack and Bruce. About Jack Sullivan Jack Sullivan is now retired. A veteran of the Boston newspaper scene for nearly three decades. Prior to joining CommonWealth, he was editorial page editor of The Patriot Ledger in Quincy,


Q:

How can I get the list of NuGet packages available for KRuntime?

It looks like only a part of BCL is supported for KRuntime. Is there a list of the assemblies in BCL that will be supported? ASP.NET vNext repositories don't include any of the System.* libraries. It would be useful to check if a library can be ported.

A:

I also found useful this myget gallery for asp.net vnext dev branch or master branch

and released slowly, while pee is thin and released in a single spurt. This meant what we designed specifically for periods didn't necessarily meet all the needs for light bladder leaks. So we dashed off to our panty workshop and engineered a prototype specifically for leaky bladders."

Icon Hi Waist Pee Proof Underwear (Sizes XS-XXXL), $34-$36, Icon Undies

Icon operates under the umbrella of THINX, and both brands are headed by CEO Miki Agrawal, an enterprising personality who came up with the idea for THINX after traveling abroad and realizing that young women in hardship areas had nothing to use during their periods. Six years after launch, THINX has become a staple item for thousands of menstruating women across the globe — and Icon is positioned to become equally as


Earth and study the atmosphere， its weather， and the effects of air pollution.

And because there is no strong gravity to break free from， our future homes away from Earth will be convenient starting points for travel to distant planets.

But， while going into space might solve some problems， outer space can also be a dangerous place. For example， in outer space， we have to protect ourselves from the dangers of ultraviolet light and cosmic rays. Ultraviolet light from the sun can give us bad sunburns right here on Earth. Yet， Earths atmosphere screens out most of that harmful radiation. Cosmic rays are tiny highenergy particles from outer space. Again， the Earth shields us from most of them.

At Home in Space？But in space， without special protection， we would be exposedIt's one of a seller's biggest dilemmas: whether to install new appliances, landscape, update a bathroom, or otherwise gussy up a place just before putting it on the market.

On the one hand, a fancy fridge or a slew of shrubs could enrapture buyers. On the other hand, however, the seller's taste in accoutrements could turn out to be a deal-breaker.

We've seen otherwise desirable properties languish because sellers paved a front yard for parking, converted a perfectly fine wood fireplace to gas, or built an oversized, inappropriate garage, cheesy storage shed, or expensive children's play equipment. While these "improvements" may suit the taste of the sellers, potential buyers with different sensibilities often find that the cost of undoing the improvement raises the purchase price beyond their budget.

This issue comes


Houston...but there are not that many hotties
Vs. the great cities of the world.
It was fun though and i value your good humour and attitude.

How to define a good girl.....or rather how do we define "good"Former Teammates, Rivals Congratulate Imran Khan

Cricketers from Pakistan and India hope the PTI chief can deliver on his campaign promises

Imran Khan’s former cricket teammates and rivals have congratulated the World Cup winner after his party won the most seats in Pakistan’s general elections.

The Election Commission said on Friday that Khan’s Pakistan Tehreek-e-Insaf (PTI) party enjoyed a strong lead over the outgoing Pakistan Muslim League (Nawaz) but was short of an overall majority.

Khan will likely need to enter into a coalition to form a government.

“Congratulating the new Prime Minister of our country,” tweeted ex-bowler Wasim Akram, who was part of Pakistan’s 1992 World Cup winning side captained by Khan. Akram had thrown his support behind Khan, 65, in the run-up to the election. “It was in your leadership skip


1. Introduction {#sec1}
===============

Renal tubules express several types of transporter that are involved in renal reabsorption and secretion, as well as ion channels for the maintenance of body fluid balance. These cells comprise polarized mature epithelial cells with the capacity to regenerate following acute kidney injury. After the insult occurs, surviving tubular cells rapidly lose epithelial cell properties and acquire a more mesenchymal phenotype. The dedifferentiated cells migrate into the regions where cell necrosis, apoptosis, or detachment has resulted in denudation of the tubular basement membrane. They proliferate and eventually differentiate into mature epithelial cells with polarized lumen, completing the repair process \[[@B1]\].

The process of restoration and maturation of damaged epithelium after renal injury has many parallels with the developmental process during kidney organogenesis. Soluble factors involved in kidneyis predominantly elicited via proliferation of endogenous renal tubular cells.

Mesenchymal stem cells (MSCs) derived from bone marrow also have been reported to enhance the intrinsic tubular recovery in several acute kidney injury models in a paracrine manner. Treatment with MSCs promoted proximal tubular cell proliferation, reduced apoptosis, and preserved microvascular integrity, leading to the amelioration of renal tissue oxygenation \[[@B73]--[@B76]\]. It is considered that MSCs interact with resident cells in endocrine and paracrine manners through the release of growth factors, cytokines, or extracellular vesicles \[[@B77], [@B78]\]. MSC-derived conditioned medium, which contains renotrophic factors and anti-inflammatory factors, was shown to be able to enhance kidney repair after injury \[[@B77], [@B79], [@B80]\]. BMDCs including MSCs are now considered to contribute to the regenerative process by producing protective and regenerative factors,


rather than by differentiating to directly replace damaged cells.

6. Conclusions {#sec6}
==============

Recently, many new concepts in the regeneration process of renal tubules after acute kidney injury have emerged. Growing evidence suggests that the immune system supports the regeneration process of the kidney after injury. Using gene targeting techniques or fate mapping analysis, the involvement of diverse cell populations including tubular cells, inflammatory cells, resident renal endothelial cells, endothelial progenitor cells, and bone marrow-derived cells has been clarified. Critical roles for neutrophils, lymphocytes, and macrophages have been established in mouse models of acute kidney injury. In addition, several studies have reported that complement, TLRs, and numerous cytokines and chemokines are clearly involved in amplifying the immune response to kidney injury. However, the complex interplay between tubular cells and neighboring cellsloss was the ninth match, against Llanelli RFC – a spirited encounter which saw the Llanelli side win the match 8–3 and themselves a place in local sporting folklore.

Olympic Wallabies
During the tour, the Olympic Games were being held in London. The Australian team entered the rugby tournament and were the only other team alongside Cornwall, who were representing Great Britain.  The interest in the Olympic rugby final was only lukewarm with the final being held in the last week of Games that had taken place over six months.

Australia had already beaten Cornwall, the British county champions early in the tour. Scottish and Irish Unions had turned down the RFU's invitation to participate in the Olympic bouts. France were expected to contest the medal, but had withdrawn, leaving


lifted the 264-pound Medbery and brought him to the mat for a first-round takedown. The Maryland native managed to score a second takedown in the second period to win the title despite having injured his ribs during the quarterfinals against Minnesota's Michael Kroells.

When asked about that injury -- and being able to lift Medbery as he did to get the takedown -- Snyder replied, "Yeah, that was a cool take-down. I don't think I ever lifted Connor up like that in practice or any matches. So that's good. Means I'm getting stronger."

The 125-pound title match featured a battle of childhood rivals in the Valley Elementary League in Pennsylvania. No. 4 Darian Cruz of Lehigh defeated sixth-seeded Ethan Lizak of Minnesota, 6-2. The match was tied through much ofNot doing the right things.

"And today I can look forward and know in two weeks I won't be in my basement with my headphones turned all the way up and crying two weeks from now. You know? So that's a good thing."

Two high school rivals from the Cleveland area faced off in the 141 pound finals. Top-seeded Dean Heil of Oklahoma State successfully defended his NCAA title -- and completed his season undefeated -- by defeating No. 6 seed George DiCamillo of Virginia, 6-3. The Cowboy scored a takedown with 45 seconds left in the third period to extend his lead.

"Last time I wrestled George in an official match, aside from the Scuffle, was my freshman year in high school," said Heil in talking about his history with


updating5.88−1.18−5.562.05na Intercept recalibration7.07−1.18−5.562.05na Logistic recalibration9.12−1.34−6.321.70na Refitting6.19−0.86−7.372.19na Penalized refitting7.87−1.14−6.421.74na Refitting + rcs24.08−0.87Replaced by rcsna Extension10.90−0.77−5.491.65−1.67 Penalized extension9.84−0.84−5.991.80−1.20Temporal updating (SGH), EP vs IUP No updating0.39−0.06−0.26−3.93na Intercept recalibration0.99−0.06−0.26−3.93na Logistic recalibration5.29−0.70−3.31−0.36na Refitting4.01−0.50−4.040.33na Penalized refitting4.86−0.64−3.33−0.33na Refitting + rcs14.44−0.48Replaced by rcsna Extension7.83−0.47−2.66−0.14−1.21 Penalized extension6.83−0.50−3.05−0.05−0.84Geographical updating (QCCH), FP vs IUP No updating5.88−1.18−5.562.05na Intercept recalibration6.15−1.18−5.562.05na Logistic recalibration5.08−0.82−3.860.61na Refitting4.74−0.75−4.040.06na Penalized refitting4.86−0.78−3.900.50na Refitting + rcs9.01−0.73Replaced by rcsna Extension5.67−0.66−3.38−0.06−0.52 Penalized extension5.45−0.73−3.650.38−0.32Geographical updating (QCCH), EP vs IUP No updating0.39−0.06−0.26−3.93na Intercept recalibration1.25−0.06−0.26−3.93na Logistic recalibration1.70−0.20−0.91−1.33na Refitting3.81−0.51−0.42−1.59na Penalized refitting3.22−0.43−0.67−1.39na Refitting + rcs0.79−0.51Replaced by rcsna Extension4.61−0.450.07−1.75−0.40 Penalized extension3.89−0.43−0.41−1.45−0.21*hCGm* the average of hCG at 48 hours and hCG at presentation, *hCGrc* the centered ratio of hCG at 48 hours and hCG at presentation, *prog* progesterone, *FPUL* failed pregnancy of unknown location, *IUP* intra-uterine pregnancy, *EP* ectopic pregnancy, *SGH* St. George's Hospital, *QCCH* Queen Charlotte's and Chelsea Hospital, *rcs* restricted cubic splines

Not applicable.

Funding {#FPar1}
=======

The research is supported by KU Leuven Research Council (grant C24/15/037) and Research Foundation---Flanders (grant G049312N). Kirsten Van Hoorde was supported by a PhDgrant of the Flanders' Agency for Innovation by Science and Technology (IWT Vlaanderen). Yvonne Vergouwe was funded by the Netherlands Organization for Scientific Research (Grant 917.11.383). Tom Bourne is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London.

Availability of data and materials {#FPar2}
==================================

Datasets will not be shared because we lack informed consent for the publication of patient data and have not sought approval from the local ethics committees.

Authors' contributions {#FPar3}
======================

BVC and KVH conceived the study. BVC, KVH, YV, and EWS designed the study. BVC and KVH performed the statistical analysis. BVC, KVH, YV, and EWS interpreted the results. SB, GC, EK, and TB acquired the patient data. BVC and KVH drafted the manuscript. YV,


helped by the current requirement that we gain additional approvals from the Department of Interior for rights-of-way permits across our own lands."

Those delays come with a cost: Nez said that of "the dollars that go to Indian Country to improve the roads, millions of dollars are utilized to go just to those clearances, and right-of-ways alone."

Lummi Nation Council Member Henry Cagey said the current system "interferes with the sovereign authority of the tribal government to determine what is appropriate use of our own land." By shifting trust land to restricted fee lands, which are "not considered owned by the United States," tribal leaders have exclusive management rights for the land.

Cagey said the bill "streamlines land-use regulation and makes it easier to develop such things as housing or businesses."

EricHenson, an executive vice president for economic consulting company Compass Lexecon, said the bill is a "very positive move forward" but "a few clarifying things" need to be addressed to avoid unforeseen consequences.

One concern raised by Henson is the lack of specific language about taxation in the bill, which could open the door to other governments taxing the restricted fee lands. Henson, who works with the Harvard Project on American Indian Economic Development, said it's "diminishing" to the sovereignty of tribal governments to dictate how they can tax their lands.

"We should treat Indian nations as nations," Henson said . "You wouldn't call France, and say, 'Hey, don't tax your citizens because we are going to do it instead. Why don't you guys start exporting more baguettes?' That would


I think you too believed."

He added: "These offences may have taken place a long time ago, when inappropriate and trivial sexual behaviour was more likely to be tolerated, but your offending was not trivial, but of a very serious nature."

Clifford is currently serving his sentence at Littlehey Category C men's prison in Cambridgeshire./*
 * Copyright 2014 Advanced Micro Devices, Inc.
 *
 * Permission is hereby granted, free of charge, to any person obtaining a
 * copy of this software and associated documentation files (the "Software"),
 * to deal in the Software without restriction, including without limitation
 * the rights to use, copy, modify, merge, publish, distribute, sublicense,
 * and/or sell copies of the Software, and to permit persons to whom the
 * Software is furnished to do so, subject to the following conditions:
 *
 * The above copyright notice and this permission notice shall be included in
 * all copies or substantial portions of the Software.
 *
 * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
 * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES


Q:

Process mathematical equations in php

A user is allowed to enter any mathematical equation they like (with one variable):
x + 5
1 - x/2
(x/3) * (56/13)
These are stored as strings in the database. When they are retrieved I need to substitute 'x' for a number and check the value of the equation.
How could I do this?
I was considering writing a parser to deconstruct the strings and turn them into equations, however this sounds expensive and problematic. The other option is to pass them through eval (but I'm not a great fan of using eval if I can help it).
Any ideas?
UPDATE:
I also need to be able to get the boolean value of something like "(x > 5)". This is not possible with evalMath
UPDATE 2:
I need to fire   * prediction. This is the fastest prediction mode that guarantees correct
     * parse results for all combinations of grammars with syntactically correct
     * inputs.
     *
     *

     * When using this prediction mode, the parser will make correct decisions
     * for all syntactically-correct grammar and input combinations. However, in
     * cases where the grammar is truly ambiguous this prediction mode might not
     * report a precise answer for exactly which alternatives are
     * ambiguous.

     *
     *


* This prediction mode does not provide any guarantees for prediction
     * behavior for syntactically-incorrect inputs.

     */
    LL,

    /**
     * The LL(*) prediction mode with exact ambiguity detection. In addition to
     * the correctness guarantees provided by the {@link #LL} prediction mode,
     * this prediction mode instructs the prediction algorithm to determine the
     * complete and exact set of ambiguous alternatives for every ambiguous
     * decision encountered while parsing.
     *
     *

     * This prediction mode may be used for diagnosing ambiguities
The basic idea is to split the set of configurations {@code C}, into
     * conflicting subsets {@code (s, _, ctx, _)} and singleton subsets with
     * non-conflicting configurations. Two configurations conflict if they have
     * identical {@link ATNConfig#state} and {@link ATNConfig#context} values
     * but different {@link ATNConfig#alt} value, e.g. {@code (s, i, ctx, _)}
     * and {@code (s, j, ctx, _)} for {@code i!=j}.

     *
     *
Reduce these configuration subsets to the set of possible alternatives.
     * You can compute the alternative subsets in one pass as follows:

     *


|A_s,ctx|=1} then there is no conflict associated with
     * {@code s} and {@code ctx}.

     *
     *
Reduce the subsets to singletons by choosing a minimum of each subset. If
     * the union of these alternative subsets is a singleton, then no amount of
     * more lookahead will help us. We will always pick that alternative. If,
     * however, there is more than one alternative, then we are uncertain which
     * alternative to predict and must continue looking for resolution. We may
     * or may not discover an ambiguity in the future, even if there are no
configuration contexts {@code x} and
     * {@code x'}. Sam checks to see if one is a subset of the other by calling
     * merge and checking to see if the merged result is either {@code x} or
     * {@code x'}. If the {@code x} associated with lowest alternative {@code i}
     * is the superset, then {@code i} is the only possible prediction since the
     * others resolve to {@code min(i)} as well. However, if {@code x} is
     * associated with {@code j>i} then at least one stack configuration for
     * {@code j} is not in conflict with alternative {@code i}.


   /// false} </returns>
    static bool allSubsetsConflict(const std::vector<antlrcpp::BitSet> &altsets);

    /// <summary>
    /// Determines if any single alternative subset in {@code altsets} contains
    /// exactly one alternative.
    /// </summary>
    /// <param name="altsets"> a collection of alternative subsets </param>
    /// <returns> {@code true} if {@code altsets} contains a <seealso
    /// cref="BitSet"/> with
    /// <seealso cref="BitSet#cardinality cardinality"/> 1, otherwise {@code false}
    /// </returns>
    static bool hasNonConflictingAltSet(const std::vector<antlrcpp::BitSet> &altsets);

    /// <summary>
    /// Determines if any single alternative subset in {@code altsets} contains
    /// more than one alternative.
 the traceability of medicinal products up to the batch number can accelerate batch recalls, thereby reducing the time that patients are potentially exposed to unsafe medication \[[@CR6]\]. A full track-and-trace system including all relevant product information will ultimately expedite the reporting of adverse drug reactions (ADRs) with the relevant exposure information and thus allow regulators to take appropriate actions as rapidly as possible.

For biologics that are the subject of a suspected ADR, it is of particular importance that the batch number, in addition to the distinct product name (e.g. brand names or name of the manufacturer), is reported, as has been highlighted in the new pharmacovigilance legislation that came into effect in July 2012 \[[@CR7]\]. Due to their distinctive properties related to the complexity of the manufacturing process,


and a soda drink (**b**) are shown. \*Some medicinal products need to be reconstituted under sterile/aseptic conditions before being administered to the patient. In such situations, the active substance of the medicinal product is distributed in a formulation package (e.g. "injectable device") that is ready for use

Whereas the primary package can be at the single-unit level, the secondary package may also involve a multi-unit package (i.e. containing multiple primary packages as seen in the example of Fig. [1](#Fig1){ref-type="fig"})[1](#Fn1){ref-type="fn"}.

In general, medicinal product information such as brand name, batch number and expiry date are provided in *human-readable* format (printed as letters and numbers) on both the primary and secondary product package levels, as required by EU regulations \[[@CR11]\]. In addition, medicinal products are provided with a barcode that can be electronicallyscanned to identify the product, e.g. by reading out a global or national trade item number. This barcode can usually be found on the outer package (i.e. secondary package).

Unfortunately, linear barcodes, which are the current standard for pharmaceuticals in the EU, have a technical limitation: these barcodes can only encode static information and thus are not able to encode variable or dynamic data such as batch numbers and expiry dates. This means that the recording of this information in these circumstances still requires resource-intensive manual processes that can be prone to human errors \[[@CR12], [@CR13]\]. It also has implications for healthcare settings that have fully developed their routine workflows around an IT-infrastructure that relies on machine-readable data formats.

Nevertheless, novel barcode technology already exists that allows for the encoding


This will require investments both in terms of time, resources, and regulatory efforts from every stakeholder involved. However, the value that can be captured both from a public health and from a cost-effectiveness perspective is significant. Moreover, the current regulatory ambitions for the pharmacovigilance of biologics, as laid down in EU legislation, cannot be met without a full track-and-trace system. The FMD shows that new barcode technology can already be implemented in the pharmaceutical sector. However, initiatives such as the FMD should be better aligned with other drug safety topics to explore its full potential to improve the traceability of medicinal products and in tandem address other public health objectives.

Exceptions may include pill bottles or blister packs, where the primary package often relates to multi-unit doses (often over-the-counter medicinal products), orV2O5: A 2D van der Waals Oxide with Strong In-Plane Electrical and Optical Anisotropy.
V2O5 with a layered van der Waals (vdW) structure has been widely studied because of the material's potential in applications such as battery electrodes. In this work, microelectronic devices were fabricated to study the electrical and optical properties of mechanically exfoliated multilayered V2O5 flakes. Raman spectroscopy was used to determine the crystal structure axes of the nanoflakes and revealed that the intensities of the Raman modes depend strongly on the relative orientation between the crystal axes and the polarization directions of incident/scattered light. Angular dependence of four-probe resistance measured in the van der Pauw (vdP) configuration revealed an in-plane anisotropic resistance ratio of ∼100 between the a and b crystal axes, the largest in-plane transport


in Greece and robber barons who have been governing all these years. Yes, we are inexperienced in covering up scandals and payoffs like the infamous Siemens scandal or the Lagarde list. Yes, we are inexperienced. We have never signed any memorandums that run contrary to the logic of macroeconomics. Yes, our thoughts are steady and so are our hands. But above all, [our hands] they are clean."

Tsipras and the other members of the SYRIZA delegation insisted throughout their visit on the need for connecting working folks and progressive movements across Europe. Their response to the Greek crisis is not a go-it-alone project. He insisted on the mutual need of Greece for the European Union, and the European Union for Greece. He and SYRIZA offer "our vision for the(**a**) 5 min, (**b**) 15 min, (**c**) 30 min, (**d**) 45 min, (**e**) 60 min, and (**f**) 90 min. Each inset shows a cross-section of the AlN nanorods.](materials-11-01140-g004){#materials-11-01140-f004}

![The inner diameter (in black) and m-plane growth rate (in blue) as a function of the growth time. The box plot representation displays the average (dark point in the box) and median (dark line in the box) values, the dispersion of the measured values through the interquartile deviation (black box), and the largest and smallest values (extremities of the vertical line). Note, the outer circle of a hexagon intersects each corner, while the inner circle touches the middle of each facet, such that $d_{i} = d_{o}.\sqrt{3}/2$. The *m*-plane growth rate was then obtained by extracting the increase of the inner radius


some rare circumstances?
Addendum:
Aside from this part that cause Undefined Behavior:
printf("%i %i %i", *(aBadBoyPointer), *(++aBadBoyPointer), *(++aBadBoyPointer));

What I really like to know is:

Is it considered OK (a good practice) using a pointer pointing to one of the members of the struct but then gain access to other members within the struct this way (by incrementing, made possible due to the memory layout of the struct members) or is it a practice that is frowned upon by the Standard?

And secondly as mentioned above, if this is in deed a bad practice, would there ever be cases where using a pointer this way within a struct and then gain access to another member variable beneficial under certain circumstances?

A:

There are a few problems, the warning you are seeing is due the unspecified orderone past the last element of the array object, the evaluation shall not produce an overflow; otherwise, the behavior is undefined. If the result points one past the last element of the array object, it shall not be used as the operand of a unary * operator that is evaluated.

We can see depending on the optimization level gcc will output (see it live):
3 3 2

or (see it live):
3 3 3

neither of which is the desired output.
The standards compliant way to access your structs members via a pointer would be to use offsetof and here, which requires including stddef.h. Accessing member a would look like this:
*( (int*) ((char*)aBadBoyPointer+offsetof(myStruct, a)) )
    ^       ^


and Technology (VAST),\
    18 Hoang Quoc Viet, Cau Giay, Ha Noi, Vietnam\
date: 'Accepted XXX. Received YYY; in original form ZZZ'
title: 'The nascent wind of AGB star R Doradus: evidence for a recent episode of enhanced mass loss'
---

\[firstpage\]

stars: AGB and post-AGB – circumstellar matter – stars: individual: R Dor – radio lines: stars.

Introduction {#sec1}
============

In a recent study of the circumstellar envelope of oxygen-rich AGB star R Dor [@Hoai2019], we commented on the detection of high Doppler velocity components confined near the line of sight and reaching up to nearly $\sim$20 [km s$^{-1}$]{}, critically comparing interpretations in terms of narrow gas streams with interpretations in terms of artefacts of improper continuum subtraction. In the present paper, we study instead the slower wind, exclusive of higher Doppler velocities.Earlier studies by @Khouri2016, @Danilovich2016, @DeBeck2018, @VandeSande2018, @Decin2018, @Homan2018 and @Vlemmings2018 have contributed a considerable amount of detailed information of relevance to the physico-chemistry and dynamics of both dust and gas in this slower wind, however without attempting a detailed description of the morpho-kinematics, which is the aim of the present paper.

R Dor, an oxygen-rich AGB star, is a semi-regular variable of the SRb type, belonging to spectral class M8IIIe, having an initial mass between 1 and 2 M$_\odot$, a mass loss rate of $\sim$1.6 10$^{-7}$ M$_\odot$yr$^{-1}$ and a temperature of $\sim$3058 K [@Dumm1998]; it is close to the Sun, at a distance of only $\sim$59 pc [@Knapp2003]; it displays no technetium in its spectrum [@Lebzelter1999] and has a $^{12}$CO/$^{13}$CO abundance ratio of $\sim$10 [@Ramstedt2014]. It has a


[@Diep2016; @Nhung2018] produces a sine wave modulation of the $xV_z$ asymmetry that cancels for $\theta=\pm$90[$^\circ$]{}and has amplitude proportional to $\sin i$, where $i$ is the angle of the rotation axis with the line of sight (the $z$ axis). Radial expansion does not produce any anisotropy if it is spherical but does if it is axi-symmetric about the axis of rotation and enhanced near the poles or near the equator. When enhanced near the poles, it also produces a sine wave modulation of the $xV_z$ asymmetry, that is instead maximal for $\theta=\pm$90[$^\circ$]{}. The combination of bipolar expansion and rotation about a same axis produces a sine wave with a phase-shift $\theta_0$ that depends on the relative importance of expansion with respect to rotation [@Diep2016; @Nhung2018].

[ccccccccccc]{} $<f>$&&&&\
Jy[km s$^{-1}$]{}& &&N&E&S&W&N&E&S&W\
\
&&$f_n$&3.18&3.64&2.56&1.93&2.17&2.06&2.52&3.44\
&&$F_n$&1.18&1.35&0.95&0.72&0.81&0.77&0.94&1.28\
&&$g_n$&0.89&1.73&$-$0.25&$-$1.38&$-$0.94&$-$1.14&$-$0.30&1.38\
\
&&$f_n$&4.15&2.62&1.66&2.47&2.30&1.65&2.74&3.22\
&&$F_n$&1.60&1.01&0.64&0.95&0.88&0.63&1.05&1.24\
&&$g_n$&2.67&0.04&$-$1.60&$-$0.22&$-$0.53&$-$1.64&0.22&1.07\

The presenceof depletions that cannot be assigned to rotation or radial expansion in the R Dor data-cube was noted by @Hoai2019 for Doppler velocities between $-$1 and $+$3 [km s$^{-1}$]{}; they can be expected to contribute significant anisotropy that will complicate the description of the data-cube in terms of rotation and expansion. Additional evidence for significant depletions of the data-cube is presented in Figure \[fig4\], which displays P-V maps in the $V_z$ vs $R$ plane, averaged over position angle $\omega$. They map the brightness $f$ and its product by the projected distance $R$, the latter giving a better representation of the situation at large distances (an isotropic emissivity inversely proportional to the square of the distance to the star and multiplied by $R$ would produce a uniform intensity). It


cores for the red-shifted enhancement and possibly four cores for the blue-shifted enhancement. The three-core structure of the former is invariant on the $V_z$ vs $\omega$ P-V map up to $R\sim1$ arcsec, beyond which distance the $V_z$ values of each of the three cores decrease by approximately 1 [km s$^{-1}$]{} over the following 0.5 arcsec. The approximate invariance of the three-core pattern as a function of $R$ favours an interpretation in terms of expansion, characterized by projective geometry, over an interpretation in terms of rotation: on average, the core values of $\omega$ and $V_z$ do not vary by more than $\pm$5[$^\circ$]{} and 0.4 [km s$^{-1}$]{} respectively. In the case of rotation, one expects inhomogeneity to display circular or spiral patterns rather than radial. On the contrary, in a radial outflow, oneFigure \[fig11\]. They correspond approximately to a torus inclined with respect to the plane of the sky, reaching extreme Doppler velocities of nearly $\pm2$ [km s$^{-1}$]{} at $\omega\sim$110[$^\circ$]{} on the red-shifted side and $\omega\sim290$[$^\circ$]{} on the blue-shifted side. The distribution of the product of the brightness $f$ by the projected distance $R$ as a function of $R-R_{cent}(\omega)$ and $V_z-V_{zcent}(\omega)$, averaged over $\omega$, is shown in the middle panel of the figure, giving clear evidence for the presence of the cavity. The dependence on $\omega$ of product $Rf$, averaged over the cavity, is shown on the right panel of the figure. It shows emission at values of $\omega$ corresponding with the crossing of the cavity by the low Doppler velocity part of the blue-shifted and red-shifted outflows identified in the preceding section.

In


for a maximum of emission near $\rho\sim1$. Figure \[fig12\] (right panel) displays the dependence of product $Rf$ on $\rho$ for both values of $V_0$, 4 and 5 [km s$^{-1}$]{}, showing a clear excess near $\rho\sim0.9$.

Comparison with other molecular lines {#sec4.4}
-------------------------------------

The circumstellar envelope of R Dor has been probed at ALMA using several other molecular line emissions, as described by @Decin2018. In @Hoai2019 we have made use of some of these observations to comment on the high Doppler velocity components of the nascent wind. In the present section we compare them with the results obtained in the preceding sections from the analysis of SO($J_K=6_5-5_4$) emission. In spite of much shorter times on source, of higher noise level and of an antenna configuration implying a short reach in $R$ theysees that the disagreement between the SiO data and the other lines is strongly enhanced at lower Doppler velocities.

![image](paper-fig15.eps){width="90.00000%"}

We have checked that this disagreement is similarly present in another SiO data set from the same project that we have reduced using ALMA pipeline standard script, GILDAS and natural weighting and have not continuum subtracted. The resulting beam size is 220$\times$170 mas$^2$ and the noise is 5.2 mJy beam$^{-1}$. The disagreement is therefore not an effect of $uv$ coverage or data reduction. @Decin2018 have commented on the nucleation process of dust grains in the radial range of relevance (their Section 5.3.2) and a detailed modelling, probably out of reach of current understanding, would be required to explain the difference between the observed morpho-kinematics of SiO and that of other


from the star ($\sim30$ and 60 au); one is red-shifted and the other blue-shifted, with Doppler velocities of $\sim2.4$ and $-3.0$ [km s$^{-1}$]{}, approximately symmetric about a position angle of $\sim140$[$^\circ$]{}; they are not quite back to back but $\sim200$[$^\circ$]{} rather than 180[$^\circ$]{} apart. Each of these outflows is dominated by two cores of nearly equal Doppler velocities, approximately 70[$^\circ$]{} apart in position angle and fainter emissivity enhancements are detected as appendices of the main cores at lower Doppler velocities.

Figure \[fig17\] gives a qualitative picture that summarizes the present results. Assuming that the four main cores of emission have a common radial velocity of $\sim9$ [km s$^{-1}$]{} and are therefore nearly coplanar, the inclination of their plane with respect to the plane of the sky is $\sim\sin^{-1}(3/9)\sim20$[$^\circ$]{}. For a common radial velocityof 6 [km s$^{-1}$]{}, the inclination becomes 30[$^\circ$]{}.

Emission from other molecular lines, detected in less favourable observational conditions than the SO line, normally confirms the presence of the radial outflows identified here and gives evidence for different molecular species probing preferentially different distances from the star. However, emission of the SiO line displays a significantly different pattern, suggesting that SiO gas populates and probes significantly different regions of the circumstellar envelope than do the other lines.

![Qualitative picture summarizing the results obtained in the present work.[]{data-label="fig17"}](fig17-picture.eps){width="40.00000%"}

High spatial resolution ALMA observations of oxygen-rich AGB stars are often revealing a much more complex morpho-kinematics than had been originally anticipated. It has been the case with Mira for now many years, recent examples are QX Pup [@SanchezContreras2018; @Olofsson2019], R Aqr [@Ramstedt2018] and


chloride ions than by other halide ions tested, using Bz-Gly-Gly-Gly as a substrate. The dissociation constant for chloride ions was determined to be 2.2 mM. Chloride did not protect the enzyme against heat or low pH. The enzyme was resistant to inactivation by trypsin [EC 3.4.21.4] and chymotrypsin [EC 3.4.21.1].[Sympathetic response in primary hypertension].
High blood pressure (BP) is a major cause of cardiovascular disease and primary hypertension is a frequent pathological condition. Sympathetic hyperactivity may be involved in primary hypertension. The purpose of this study was mainly to evaluate sympathetic activity when performing cardiovascular autonomic profile examination in patients with primary hypertension in comparison with normotensive subjects. This prospective study included one group of hypertensive patients (n=120, mean age 54 years) compared with a control group (n=120, mean age 52 years) of normotensive subjects. Autonomic tests included deep-breathing (DB), hand-grip (HG) and echostress test (ES). Comparison tests between the two groups, similar in age, were expressed as mean+/-SE and made using the t Student test, p<0.05 was considered significant. Alpha-adrenergic sympathetic response using ES method produced a


8*u - 65. Let b be w(u). What is the third biggest value in 4, 8, b?
b
Let k = 0.6 - 0. Let u = k - 0.8. What is the biggest value in u, 2/17, -0.1?
2/17
Let d = -1 + -9. Let f = -7 - d. Let p = 989/7 - 141. Which is the smallest value?  (a) f  (b) 0.5  (c) p
c
Let s = 8.6 + -0.6. Let d = 3 - s. Which is the third smallest value?  (a) -3  (b) d  (c) -0.3
c
Let p = 67 + -67.2. Let s be (-8)/70 + (-8)/(-20). What is the third biggest value in 1/8, p, s?
p
Let m = -4 + 3.97. Let s = 0.83 + m. Let pkind of hypnosis?" "I wouldn't dare." "No!" "Shut up!" "I feel sorry for you, Kaneko." "First you lose your gun and get kicked of the force." "Then you become a yakuza, which is OK." "But now you have a killer on your heels." "You're an unlucky monkey." "I have no regrets." "I've got lots of them." "The only reason I ended up in this business is because I was tough." "Sometimes I look at those salary slaves... imagining I could have easily ended up that way, living such a life." "What will you do when all this is over?" "I only want revenge for boss Anjo." "There will be no one left to taste our revenge." "Think about your son." "He'll have to manage on his own." "I


News retracted an article on Rich on Tuesday, saying the piece “was not initially subjected to the high degree of editorial scrutiny we require for all our reporting”.

Cars.com told Buzzfeed it does not “have the ability to influence content at the time we make our advertising purchase. In this case, we’ve been watching closely and have recently made the decision to pull our advertising from Hannity.”

USAA sent more than 30 tweets on Wednesday responding to complaints over its Hannity advertising.

“We are no longer advertising in relation to Hannity. Thank you!” one reply said. In a series of other messages USAA said “advertising on opinion shows is not in accordance with our policy and we’ve since corrected it.”

Bill O’Reilly left Fox News in April after allegations of sexual harassmentRCS Pinellas at www.rcspinellas.org or email info@rcspinellas.org.

Welcome

The road to homeownership doesn't have to be scary.

With the Mortgage Minute, we'll keep you up-to-date on all the latest happenings at VanDyk. Along the way, we'll provide you with the tools and knowledge you need to navigate the mortgage process with confidence.


1099 bp. The size distribution of these unigenes is shown in Additional file [1](#MOESM1){ref-type="media"}: Figure S1 and Table [1](#Tab1){ref-type="table"}. All raw transcriptome data have been deposited in the National Center for Biotechnology Information (NCBI) SRA database, and the accession number can be found in the "Availability of supporting data".Table 1The size distribution of contigs, transcripts and unigenes identified in the transcriptome of *S. salsa* dimorphic seedsContigsTranscriptsUnigenesTotal number11,824,856208,58891,753Total length566,541,417220,255,28064,367,580N50 length4817511099Mean length47.911055.93701.53

Selection and identification of DEGs {#Sec4}
------------------------------------

A total of 36,318 unigenes (39.58%) were identified with a significance threshold. A total of 5825 genes were found to be differentially expressed in black and brown seeds. Among them, 2919 genes were upregulated and 2906 genes were downregulated in brown seeds, compared to black seeds (Fig. [1](#Fig1){ref-type="fig"}).Fig. 1The number of DEGs of *S. salsa* dimorphic seeds

Functional annotation ofAdditional file [5](#MOESM5){ref-type="media"}: Table S4. Red indicates the corresponding DEGs that were upregulated in brown seeds, green indicates the corresponding DEGs that were downregulated in brown seeds, blue indicates some of the corresponding DEGs that were downregulated and the others that were upregulated, and those without any color indicate the expression level of corresponding genes that did not change

Genes involved in betaine, proline, sodium, chloride, potassium and calcium accumulation {#Sec10}
----------------------------------------------------------------------------------------

Numerous DEGs were annotated to the GO classification, and may be related to betaine, proline, sodium, chloride, potassium, and calcium accumulation, which were 2, 12, 11, 3, 18, and 93, respectively (Fig. [6](#Fig6){ref-type="fig"}). Most DEGs such as genes related to sodium ion transport (GO: 0006814), chloride transport (GO: 0006821), voltage-gated chloride channel activity (GO: 0005247), potassium ion transmembrane transport (GO:


under salt stress \[[@CR41]--[@CR43]\]. Proline and betaine, which can adjust osmotic potential and stabilize biological macromolecules, are two important osmotic regulation substances \[[@CR41], [@CR44]\]. Compared to black seeds, genes that could encode betaine aldehyde dehydrogenase (*BADH*) were upregulated (Additional file [6](#MOESM6){ref-type="media"}: Table S5). Li et al. found that overexpressing the *BADH* gene, which was cloned from *Suaeda liaotungensis* in tobacco, could improve the salt tolerance of transgenic tobacco by producing betaine \[[@CR45]\]. Therefore, the upregulation of *BADH* (Additional file [6](#MOESM6){ref-type="media"}: Table S5) may help brown seeds accumulate more betaine than that of black seeds. Yokoishi and Tanimoto found that an increase in betaine appeared to secure seed germination under salt stress in halophyte *Suaeda japonica* \[[@CR46]\]. Genes (*fis1*) that may encode aldehyde dehydrogenase, which are most likely theRNA Kit R6827-01; OMEGA, Beijing, China), according to manufacturer's instructions. Then, these were examined using a NanoDrop ND1000 spectrophotometer (NanoDrop Technologies, Wilmington, DE, USA) and characterized on 1% agarose gel electrophoresis. The standards applied were OD260/OD230 ≥ 1.0, and 1.8 ≤ OD260/OD280 ≤ 2.2. The RNA integrity number (RIN) values (\>8.0) of these samples were assessed using an Agilent 2100 Bioanalyzer (Santa Clara, CA, USA). At least 20 μg of RNA was pooled in an equimolar fashion from each of the samples. Two replicates of black seeds (T1 and T2) or brown seeds (T3 and T4) were performed in this study, and each sample had 0.5 g of seeds.

Illumina sequencing and de novo assembly {#Sec19}
----------------------------------------

In this experiment, mRNA was enriched and purified with oligo (dT)-rich magnetic beads, and the cDNA libraries were constructed. We tested the


its additional files. All raw transcriptome data have been deposited in the National Center for Biotechnology Information (NCBI) SRA database with the accession number of SRR5877206, and SRR5877205 for black seeds; SRR5877204, and SRR5877203 for brown seeds. Access to the data is available upon publication at <http://www.ncbi.nlm.nih.gov/bioproject/395283>.

YX wrote this manuscript; YX and YZ performed the experiments; HD, NS and FY helped in collecting data and data analysis; JS conceptualized the idea and revised the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate {#FPar3}
==========================================

Not applicable.

Consent for publication {#FPar4}
=======================

Not applicable.

Competing interests {#FPar5}
===================

The authors declare that they have no competing interests.

Publisher's Note {#FPar6}
================

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Lagrange polynomials defined on this interval. We refer the reader to [@SZTT_SISC17] for the further implementation details.

Experiments {#sec:experiments}
===========

#### COD images

The aforementioned algorithm has been tested on data from two GOES serving the west-hemisphere, GOES-15, the WEST satellite located over the Equator at west longitude and GOES-13, the EAST satellite located over the Equator at west longitude. The COD products of 15 minute interval and  4 km spatial resolution are derived from GOES data using CLAVR-x [@Thomas_Met_2004] made available by the NOAA Advanced Satellite Products Branch and Cooperative Institute for Meteorological Satellites Studies at the University of Wisconsin – Madison’s Space Science and Engineering Center (SSEC). All data are on a longitude-latitude grid with uniform spacing. The area $\Omega$ covered by the data extends from East (longitude) and North (latitude) to


that moving away from the equator ($|\varphi|$ increasing), the transformation, , compresses the grid longitudinally, and expands it latitudinally. The velocity transformation, , accounts for this by respectively increasing and decreasing the magnitudes of the latitudinal and longitudinal components of the velocity field with increasing $|\varphi|$ in transforming from the $(\lambda,\varphi)$ coordinate system to the $(x,y)$ system.

To advect COD images we employed the algorithm of Section \[sec:dG\]. We set $\Omega:=[-15567,-13788]\times[4009,4951]$ and discretize $\Omega$ with $200\times 200$ elements of order $N=3$. The timestep was selected depending on the advection coefficients speed to ensure that the CFL condition holds. The advection starts at 22:15 and uses the predicted velocity field ${\vec{u}}$ from NSE to predict dynamics of COD images up to 23:30. We compared this prediction against two most popular predictions,      **49**
  23:00                      **42**   **77**        **48**
  23:15                      **48**   **100**       **56**

  : Relative mean absolute percentage errors: ${100\%\sum_{s\in I}|C_{\mathrm{true}}(\bm{x}_s,t)-C_{\mathrm{predicted}}(\bm{x}_s,t)|}\,/\,{\sum_{s\in I}|C_{\mathrm{true}}(\bm{x}_s,t)|}$.

Here $I$ is a set of indices of the grid points, which exclude the outliers. As noted above, in Section \[sec:optflow\], some COD image values are abnormally high due to acquisition problems. These points (about 10%) are therefore excluded from the assessment.

Conclusion {#sec:conclusion}
==========

This work


coefficients of $P_{N_x,N_y}\hat\omega$, and define $\hat{\bm q}$, $\bm{v}_k$, $\bm{u}_k$ analogously. Note that $\hat{\bm\omega} = \Psi_{\frac1{\sqrt{2}},1} \Psi_{\frac1{\sqrt{2}},1}^\star\hat{\bm\omega}$, provided $\Psi_{a,b}$ is an $(N_x+1)(N_y+1)$ projection matrix defined by: $\Psi_{a,b}=
a\left( \begin{smallmatrix}
I&0&bJ\\0&0&0\\ J&0&-bI
\end{smallmatrix}
                    \right)$, i.e. $\hat{\omega}_{-\frac{N_x}2+k,-\frac{N_y}2+s}=\overline{\hat \omega}_{\frac{N_x}2-k,\frac{N_y}2-s}$ for any $0\le k,s\le \frac{N_x}2,\frac{N_y}2$ and $\hat{\omega}_{0,0}=0$ ($\hat\omega$ has zero mean!). We derive the expression for the gradient of $J$ by using a so-called adjoint method: one computes Gateaux derivative of $J$ w.r.t. $\hat{\bm q}$, obtaines a linear ODE for the gradient, and, finally, uses its adjoint equation to find the gradient explicitly ($m:=(N_x+1)(N_y+1)$): $$\begin{split}
&J_{\hat u}(\hat{\bm q},\hat u,\hat v)=2\sum_{k=1}^{N_c} (d_k,\bm{\omega}^{\hat u}(t_k))_{C^m} - (u_k - \hat u,1)_{{L^2(\Omega)}} \\
&\dfrac{d\bm{\omega}^{\hat u}}{dt} = -B(\left[\begin{smallmatrix}1\\0
\end{smallmatrix}\right])\hat{\bm\omega}-B_1(\hat{\bm\omega})\bm{\omega}^{\hat u} - B(\bm u) \bm{\omega}^{\hat u}- B(\hat{\bm\omega})\bm{\omega}^{\hatdays later on 18 May 2012.

BJP MP from Bikaner and former IAS officer Arjun Meghwal wondered why Robert Vadra had to invest in dead land in Bikaner. "One can understand Vadra investing in the Gurgaon realty sector, but why Bikaner of all the places,'' asked Meghwal.

Well, he has his answer now. Bikaner is fast emerging to as the next solar hub in the country! And Robert Vadra made his hay in the sun.