Charles Fenno Hoffman, the poet and novelist, "No, stranger, there's no place on the universal 'arth like old Kaintuck: she whips all 'Out-west' in prettiness; and you might bile down cr'ation and not get such another State out of it."

When one considers the cross-section of early immigrants, ScotchIrish, plain Irish, gentlemen from Virginia, pineys from North Carolina, French bourgeoisie, thrifty Swiss, German farmers, Shakers, Millerites, gamblers, lawyers, speculators, highwaymen, adventurers and smoothies, the suspicion arises that the new paradise was to be more a state of the flesh than the spirit, that the travelers came, actually, to raise hell in the Garden. Well—some did and some didn't. An agrarian society with romantic overtones developed in a land dripping with fatness, a way of life involving blooded horses, barbecues,Kentucky the salutation was, "Stranger, sit down. What will you take?" Unforgettable was the gesture of the courtly Kentuckian who uncorked his last bottle of W. L. Weller Straight Kentucky Bourbon, distilled in 1917 and not a day younger than forty-five years, to compliment this undeserving writer who was neither a colonel, a lawyer nor kinfolks, and whose Kentucky forebears struck out for Illanoy a hundred and thirty years ago for reasons not pertinent to this discussion. The whole atmosphere of Kentucky tradition is suffused with the aroma of fine whiskey. A Kentucky historian, J. Stoddard Johnston, once declared that the nations who lead the march of civilization and Christianity, who are patrons of art, science and literature are also alcohol-drinking peoples. On such a scale of values,


the mound builders in curious pictographs. As a matter of prosaic fact, he bought the formula from a man named P. H. Jordan.

Thompson made no claim that he had inherited from his grandfather the knack of producing a superior sour mash whiskey. In fact, he continued, none of his ancestors was versed in the distilling art, though many "were rated as fairly good consumers." Daniel Boone, Simon Kenton, James Harrod and the other legendary heroes and Indian fighters of the Kentucky Valhalla died, Thompson admitted, without ever tasting a drop of his Old Jordan, "a sad and melancholy fact," he lamented, "which entitles them to the sympathy of all."

To finance rising costs and larger investments, the distillers had to borrow more and more money. This resulted in thecontrol of liquor consumption. Taxes can reduce the total. They can shift consumption from one economic class to another. They can rearrange the patterns of usage. The alcohol tax is the prime instance in the modern state of the regulation by law of personal habits which are adjudged to be good or bad according to the consensus of the community. The whiskey trade has had many occasions for meditating on Chief Justice John Marshall's famous dictum in _McCulloch v. Maryland_ , "the power to tax involves the power to destroy."

When the United States took charge of the manufacture of all alcoholic drinkables, there came into being an army of officials, inspectors, gaugers, government aides called "storekeepers," guards and intricate regulations as to the seals, stencil plates (after 1868,


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Deventer Boekenmarkt

04 Aug. 2019

On Sunday, August 4, 2019, the 31st edition of the Deventer Books Market will take place in the Hanseatic city of Deventer. In total, more than 850 stalls are filled with many thousands of books: over 6 kilometres of market with the participation of renowned bookshops and antiquarian bookshops from all over the Netherlands. The market starts at 9.30 am, but there are the first visitors at 7.00 am.

The Deventer Book Market takes place every year on the first Sunday in August and is visited by more than 125,000 people. As a result of the large number of stalls, the Deventer Books Market has grown to become the largest in Europe. However, the market is not only characterised by quantity, butcontrast, as we have already noted, the district court in this case did consider the defendants' ability to pay.   Moreover, as we stated in McClellan, the restitution "statute does not say that indigency is a defense, only that it is a factor the judge is required to take into account."  868 F.2d at 213 (quoting United States v. Fountain, 768 F.2d 790, 802-03 (7th Cir.1985), cert. denied, 475 U.S. 1124, 106 S.Ct. 1647, 90 L.Ed.2d 191 (1986));  see also United States v. House, 808 F.2d 508, 510 (7th Cir.1986) (That a defendant is "indigent ... does not preclude an award of restitution.")   In ordering the restitution, the district court commented on the "immensity of the talent and the intelligence and the articulateness


186 F.2d 18
ARNOLD, Acting Collector of Internal Revenue,v.GREEN et al.
No. 13144.
United States Court of Appeals Fifth Circuit.
January 10, 1951.

Edward J. P. Zimmerman, Ellis N. Slack, Robert N. Anderson, Sp. Assts. to Atty. Gen., Theron Lamar Caudle, Asst. Atty. Gen., Frank B. Potter, U. S. Atty., Fort Worth, Tex., O. Morris Harrell, Asst. U. S. Atty., Dallas, Tex., for appellant.
Wentworth T. Durant, William S. Campbell, Dallas, Tex., for appellee.
Before HUTCHESON, Chief Judge, and HOLMES and RUSSELL, Circuit Judges.
PER CURIAM.

1
This is an appeal from a judgment in a family partnership case tried to the court without a jury. Entered after a full hearing and upon findings that the partner taxpayer and his daughters had intended in good faith to form, and had in fact formed, a valid partnership, the collectorconcentration. ROS generation by allergens was not detected at nontoxic concentration but as the concentration was increased to a toxic dose there was a drastic increase in the ROS level compared to the untreated cells. Hence, the regulation of ROS is not significant in allergic responses but important in irritant responses. The major difference exists in the fact that the source of ROS for irritants is mitochondria, while that of allergens is mostly cytosolic. Antioxidant-induced protection from irritant-induced cell death has also been demonstrated. NO level was found to increase by allergens and irritants in a concentration-dependent manner. Hence, the regulation of ROS and NO can be used as important mediators in contact allergic and irritant dermatitis.


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Differential effects of dietary fibers on rat intestinal circular muscle cell size.
The relationship between dietary fiber and intestinal circular muscle cell size was investigated in rats by feeding defined diets supplemented with four different sources of fiber. In the first study, a 20% wheat bran supplement was fed to 10 rats for nine weeks. This resulted in larger muscle cell size, with a 22.5% increase in the proximal (P less than 0.02) and 77.9% increase in the distal colon (P less than 0.01) when compared with a control group of 10 rats fed a fiber-free diet. In the second study, which lasted four weeks, a control group of 10 rats was fed a fiber-free diet, while similar sized experimental groups were fed the same basal diet plus either


student’s understanding of key telecommunications systems concepts.

The distance learning version of TIMS called net*TIMS allows real-time hardware experiments to be delivered across the Internet, where student control the experiments from any location.

Emona Instruments has an active design and development program. Each year Emona releases new hardware building blocks, ensuring that TIMS stays at the forefront of telecommunicationsOn Monday, the United States Human Rights Network held its National Day of Action for the International Covenant on Civil and Political Rights, in recognition of the United States’ upcoming ICCPR review before the United Nations in October. In light of recent activities — including the repeal of Title V of the Voting Rights Act, drone bombing on international targets without a declaration of war, electronic surveillance abroad and at home and the continuing occurrence of police misconduct like New York City’s “stop-and-frisk” policy — the nation will have a lot to answer for.

The ICCPR is a binding human rights treaty that 167 countries — including the United States — entered into in 1976. The U.S. Senate ratified it into law in 1992 with five reservations, five understandings


lines that they know will work very well together, the downside is that lucky
accidents of synergy are less likely to be encountered. Paul seems to be trying
to use his experience to spot combinations that will work well together, that
may not seem obvious to the casual observer.

I was especially interested in the Jean Marie Reynaud range of loudspeakers that Paul imports. There are different quality levels and different sizes at each pricepoint. The pricepoints are not those typical of UK manufacturers, which might suggest that they're built to an idea rather than a market sector. This makes comparison difficult with rival brands on a similar-model value-for-money basis. So "I will not reason and compare"
(William Blake).

The JMR Arpeggione loudspeakers are originals, despite a superficial resemblance to several of the many10AM PT.

https://www.surveymonkey.com/r/PackTitleVote

When we select a name, our primary criteria is that the name says something descriptive about the contents of the pack, so that it can catch someone’s attention. Stuff Packs in particular have a narrower scope than other packs for The Sims, so our names tend to be direct and to the point. The recent release of “Toddler Stuff” is a great example that immediately tells you if you’re interested in learning more about what the pack has to offer. Looking further back in the catalog, “Cool Kitchen Stuff” is an example where we tried to be clever, and reference both the gameplay and the style within the title. “Cool” being a reference to the ice cream machine, and “Kitchen” of course referring to the setting. I


under way, we’ll have real in-game progress to share soon!

Following today’s survey, there’s one more opportunity to directly influence this pack through the power of your vote. Come back next week and help select which icon will represent this pack.Preparation and property of high strength and low friction PVA-HA/PAA composite hydrogel using annealing treatment.
PVA hydrogels have desirable characteristics for use as soft tissue substitutes. However, PVA hydrogels are not high strength enough to withstand the demanding in load-bearing environment of human. In this paper, a high strength and low friction PVA-HA/PAA composite hydrogel is obtained by freezing-thawing and annealing method. The microstructure, thermal stability, mechanical and biotribological properties of the hydrogel are studied. Annealing PVA-HA/PAA composite hydrogel has porous structure, interaction occurred between PVA, HA and PAA. HA particles are distributed in PVA matrix and played a role of diffuse strengthening and toughening. Annealing improves the crystallinity and crosslinking of the hydrogel, annealing PVA-HA/PAA composite hydrogel has good thermal stability, strength and mechanical properties. The tensile strength


takes up less room on a notebook, allowing manufacturers to build thinner ultrabooks or laptops with beefier specs or larger capacity batteries.

Other applications for ForcePad include gaming and Synaptics says that it is working with independent software vendors to create third-party apps and games that leverage the ForcePad technology. ForcePad will begin to appear in the next generation of laptops and ultrabooks starting in 2013.Q:

How can I have a validation formula for a Decimal field that is only tested if the field is non-blank

In Form Builder, I have a control of Data Type: Decimal. Required is set to No. I want to have a validation error if a value entered is not positive. But I don't want a validation error if the field is blank. I have tried a lot of formulas such as these:
xxf:is-blank(xs:string($control-2)) or $control-2 > 0
string-length(xs:string($control-2)) = 0 or $control-2 > 0

xxf:is-blank($control-2) or $control-2 > 0
string-length($control-2) = 0 or $control-2 > 0

If the field is non-blank I can convert it to string with xs:string() without any issue but if it's blank then this conversion fails. Is there any formula to test for a blank Decimal value?

A:

If in Form Builder


<item name="android:dividerHeight">0dip</item>
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    components and design, and ways of measuring head (vertical drop) and water flow at your site. This time, I’ll discuss calculating the power available from a given stream, system efficiency, options for transmitting electricity from your hydro turbine to your home, and several other factors that make a good hydro system.

Computing Water Power

Net head is the vertical drop from your pipeline intake to your turbine, adjusted for pipe friction (losses caused by water moving through a pipeline). Design flow is the amount of water you have to work with. See “Intro to Hydropower, Part 2” in HP104 to learn how to measure these two important site variables. Once you’ve determined net head and design flow, you can begin to estimate the potential output of a hydro system. These


help you determine the best solution for your site.

What Makes a Quality Hydro System?

Think of a hydroelectric system in terms of efficiency and reliability. In a perfect world, efficiency would be 100 percent. All the energy within the water would be transformed to the rotating shaft. There would be no air or water turbulence, no mechanical resistance from the turbine’s bearings or drive system, and the runner would be perfectly balanced. The signs of energy loss—heat, vibration, and noise—would be absent. Of course, the perfect turbine would also never break down or require maintenance.

Obviously, no turbine system will ever achieve this degree of perfection. But it’s good to keep these goals in mind, because better efficiency and reliability translate into more power and a lower cost per watt.DC or AC), but most are happy to refer you to someone else when appropriate.

Emphasize efficiency. Your head and flow determine how much raw water power is available, but efficiency determines how much of it you’ll be able to transform into usable electricity. There are cost trade-offs, of course, but in many cases, a more efficient system will result in a lower cost per watt. This is especially important if you’re thinking of connecting to the grid, where higher efficiency means more dollars in your pocket.

I hope you have found this series of articles on hydropower helpful. I’ve only scratched the surface of this substantial topic, but I hope I’ve whetted your appetite. As you’ve seen, the concepts behind hydropower are simple. Water turns a turbine, the turbine


(Grimmelsman) discloses a core catcher for use in a core barrel or well core drill. As shown in FIG. 6, the catcher includes spring-biased dog assemblies 31 and serrated gripping elements 32, which are adjustable along the longitudinal axis of the catcher.
U.S. Pat. No. 2,103,611 (Catland et al) discloses a core catcher which includes spring-biased dog assemblies 33 and wedge-like gripping parts 35 which are adjustable along the longitudinal catcher structure.
U.S. Pat. No. 2,595,008 (Still) discloses a tool for use in gripping and pulling broken pipes from oil or like deep wells. The extractor includes a cylindrical roller or shaft 16 with a knurled surface for engaging the surface of the broken pipes.
U.S. Pat. No. 1,754,816 (Canniff) discloses a sucker rod socket for retrieving broken sucker rods orleast 3.5 million unique customers a total of more than 25 million times. According to the FTC’s complaint, consumers in AT&T focus groups strongly objected to the idea of a throttling program and felt “unlimited should mean unlimited.” AT&T documents also showed that the company received thousands of complaints about the slow data speeds under the throttling program. Some consumers quoted the definition of the word “unlimited,” while others called AT&T’s throttling program a “bait and switch.” Many consumers also complained about the effect the throttling program had on their ability to use GPS navigation, watch streaming videos, listen to streaming music and browse the web. The complaint charges that AT&T violated the FTC Act by changing the terms of customers’ unlimited data plans while those customers were


still cancer." "You know how I know?" "He's got an oncologist for a doctor." "And your magical leukemia detector is more powerful than a flow cytometer?" "I look for zebras because other doctors rule out all the horses." "In this case, you are those other doctors." "You haven't earned a zebra." "Hundred bucks." "Are you serious?" "Look, friends don't diagnose friends with cancer." "I get it." "Your problem is you're not objective." "Your caring is clouding your diagnosis." "If you just cut that out, you could be a pretty decent doctor." "Just give me the lactic acid level." "Twenty-seven." "(MAN CONTINUES GROANING)" "The fact that you can't speak English is not an excuse for you not being humiliated by what I'm about to say." "It's also not anthat the logical course in any adult relationship could one day lead to fornication." "Although, the fact that she wants to buy a loft could actually mean that their relationship is not as serious as I thought." "Oh, for God's sake, House, don't do this to yourself." "It's a loft, it has no deeper meaning than open-spaced living arrangement." "You bought into her diatribe about rediscovering her lost city-girl roots?" "And two bedrooms, it just reeks of commitment issues." "Yeah, or she has a baby." "Well..." "This is classic mid-life Cuddy crisis." "This is her version of a two-seat convertible." "Yep, clearly you're fine with it." "Wilson, he's got global lung damage." "Means it's not fungal." "It's PCP pneumonia." "Hmm." "Obviously, something is knocking out his immune system."


life." "Does he have to go through another bone marrow transplant?" "No." "Chemotherapy." "We can go at this with drugs alone." "When do we get started?" "We begin by surgically planting a shunt, so we can get the drugs directly into your brain." "I already booked the OR." "You're the only one who can make cancer sound like good news." "We get it out of your head and you walk out of here." "Paralysis gone and cancer free." "We also need you to sign a healthcare proxy." "If something goes wrong in surgery, someone needs to be appointed to make decisions for you." "What are the chances of that happening?" "Very remote." "I think maybe Melissa should be my proxy." "What?" "No." "Coming through." "House got a newignoring you to make a point." "There is a difference." "The problem with that technique is I have no idea what point you're making." "That your idea is implicitly not worth responding to." "Doubling your patient's chemo dose is stupid." "Damn, now it's explicit." "It could swamp out the resistance of the cancer cells." "The fact that it theoretically should work doesn't make it any less stupid." "Of course it does." "It's exactly what you would do." "I'm me." "You're you." "And a table is a table." "And chemo is poison, and double chemo is double poison." "And I can handle it when things go wrong." "You can't." "And things could go very, very wrong." "I can handle it." "Sounds pretty dangerous." "It is." "What do you think,


the whole thing, just one small piece." "Then I'm not defiling a dead body." "House." "The last generous act of a living person." "House." "It's too late." "The liver started to degrade." "It's no longer viable for transplant." "Well played." "Religion just killed another person." "It's not fair, Jim." "You just helped me get my family back together." "I'm not ready." "(SNIFFLING)" "I would've had six more months with them if you hadn't given me that extra chemo." "Now I have less than one day." "I'm sorry." "We knew the risks." "I don't want to lose them again." "I can't lose them again." "There's nothing more we can do." "Five years ago, when I needed a transfusion, you used your own blood." "We have the same type, which"Tucker wants me to donate a lobe of my liver to him." "You were out drinking because you're actually considering this?" "Yeah, I was out marinating my liver in alcohol to get it ready for the transplant." "Yeah." "Your mouth says no, but your pathetic attempt at a deflection has guilt written all over it." "It's my fault." "It is my fault." "I gave him too much chemo." "You cured his cancer." "And killed him in the process." "Quibbles." "(LAUGHS)" "He's had a predictable complication." "Surprise." "Bad things happen to people who are sick." "Doesn't make you responsible." "Oh." "Not legally, ethically." "Ethically." "A table is a table." "Don't be a doormat, Wilson." "Boy, you are..." "You willfully ruined my food and have taken over my living room


an particular url[i] element does not modify the overall structure of the url vector, so the processing overhead is no different to over-writing a single variable. (see http://adv-r.had.co.nz/C-interface.html#c-data-structures for particulars).
Re-sizing (by adding an element to) the url (and id, and time) vectors involves regularly re-building the entire vector.
tl;dr On-the-fly building or re-sizing of vectors is expensive.

  NSAssert1(0, @"Error while creating insert statement. '%s'", sqlite3_errmsg(database));
}

sqlite3_bind_text(insertStmt, 1, [Gunameq UTF8String], -1, SQLITE_TRANSIENT);
sqlite3_bind_text(insertStmt, 2, [Gpassq UTF8String], -1, SQLITE_TRANSIENT);
if(SQLITE_DONE != sqlite3_step(insertStmt))
    NSAssert1(0, @"Error while inserting data. '%s'", sqlite3_errmsg(database));
else
    NSLog("Inserted");
//Reset the add statement.
sqlite3_reset(insertStmt);
insertStmt = nil;


cell lung cancer (Iwai *et al*, [2002](#emmm201606674-bib-0029){ref-type="ref"}; Topalian *et al*, [2012](#emmm201606674-bib-0051){ref-type="ref"}; Hamid *et al*, [2013](#emmm201606674-bib-0022){ref-type="ref"}). However, although PD‐L1 is expressed in human PDAC samples (Spivak‐Kroizman *et al*, [2013](#emmm201606674-bib-0048){ref-type="ref"}; Hutcheson *et al*, [2016](#emmm201606674-bib-0027){ref-type="ref"}), monotherapy with PD‐L1 inhibitors lacked efficacy in this disease (Brahmer, [2012](#emmm201606674-bib-0004){ref-type="ref"}). This can be attributed to the fact that PDAC is a "non‐immunogenic" tumor characterized by low mutational burden (Liu *et al*, [2011](#emmm201606674-bib-0033){ref-type="ref"}), lack of CD8^+^ T‐cell infiltration (Ino *et al*, [2013](#emmm201606674-bib-0028){ref-type="ref"}), and the presence of immunosuppressive myeloid cell populations (Dunn *et al*, [2002](#emmm201606674-bib-0015){ref-type="ref"}; Stromnes *et al*, [2015](#emmm201606674-bib-0049){ref-type="ref"}).

Radiotherapy can activate the immune system to trigger an anti‐tumor immune response following cytotoxic death and release of immunostimulating signals that can increase trafficking of T cells to the tumor (Burnette & Weichselbaum, [2013](#emmm201606674-bib-0006){ref-type="ref"}; Formenti & Demaria, [2013](#emmm201606674-bib-0020){ref-type="ref"}). Although studies have proposed the use of immunomodulators to enhanceCD8 T cells and, importantly, prevents the establishment of suppressive microenvironment factors ([Appendix Fig S11A and G](#emmm201606674-sup-0001){ref-type="supplementary-material"}).

Discussion {#emmm201606674-sec-0010}
==========

PD‐L1 plays a central role in permitting cancer evasion, mainly by interfering with T‐cell functions, and inhibitors of the PD‐1/PD‐L1 axis have changed the paradigm in the management of melanoma patients (Clark *et al*, [2007](#emmm201606674-bib-0009){ref-type="ref"}). However, PDAC is characterized by a highly immunosuppressive stroma (Hiraoka *et al*, [2006](#emmm201606674-bib-0026){ref-type="ref"}; Lutz *et al*, [2014](#emmm201606674-bib-0034){ref-type="ref"}; Beatty *et al*, [2015](#emmm201606674-bib-0002){ref-type="ref"}; Diana *et al*, [2016b](#emmm201606674-bib-0013){ref-type="ref"}; Zhang *et al*, [2017](#emmm201606674-bib-0055){ref-type="ref"}) and immune checkpoint inhibitors alone were ineffective in the clinical setting (Royal *et al*, [2010](#emmm201606674-bib-0041){ref-type="ref"}; Brahmer *et al*, [2012](#emmm201606674-bib-0005){ref-type="ref"}). Evidence indicates potentially complementary roles for immunotherapy and RT (Sharabi *et al*, [2015a](#emmm201606674-bib-0043){ref-type="ref"}), but this combination has not been explored in PDAC. Here, we show that blockade of PD‐L1 strongly enhanced tumor response to high (12, 5 × 3, and 20 Gy)


but not low (6 and 5 × 2 Gy) RT doses, albeit a trend was noted for low doses. In addition to sensitizing tumors to RT, anti‐PD‐L1 improved response after gemcitabine‐based chemoradiation. This is, to our knowledge, the first preclinical study to examine in detail the impact of this therapeutic strategy in PDAC. Our findings support and build on previous preclinical reports demonstrating enhanced radiosensitization using CTLA‐4 and/or PD‐1/PD‐L1 immune checkpoint inhibitors in melanoma, breast, and colorectal cancer, and glioblastoma multiforme (Demaria *et al*, [2005](#emmm201606674-bib-0010){ref-type="ref"}; Deng *et al*, [2014](#emmm201606674-bib-0011){ref-type="ref"}; Dovedi *et al*, [2014](#emmm201606674-bib-0014){ref-type="ref"}; Sharabi *et al*, [2015b](#emmm201606674-bib-0044){ref-type="ref"}; Twyman‐Saint Victor *et al*, [2015](#emmm201606674-bib-0052){ref-type="ref"}; Rodriguez‐Ruiz *et al*, [2016](#emmm201606674-bib-0040){ref-type="ref"}).

Although our observations with higher RT doses are in agreement with the majority of reports showing strong radiosensitization with PD‐1/PD‐L1 (Demaria *et al*, [2005](#emmm201606674-bib-0010){ref-type="ref"}; Deng *et al*, [2014](#emmm201606674-bib-0011){ref-type="ref"}; Dovedi *et al*, [2014](#emmm201606674-bib-0014){ref-type="ref"}; Sharabi *et al*, [2015b](#emmm201606674-bib-0044){ref-type="ref"};gemcitabine, cell lysates were prepared in RIPA buffer containing protease inhibitor cocktail (Roche) and phosphatase inhibitor cocktail (Roche). In total, 30 μg of proteins were separated on SDS--PAGE (Invitrogen) and transferred to Hybond‐C membranes (Amersham Biosciences). Standard procedures were applied for Western blotting. The following antibodies were used: Stat1, phospho‐Stat1 (Y701), Stat3, mouse PD‐L1 (all from R&D Systems), actin (Cell Signaling).

Cytokine profile and SDF‐1 ELISA in KPC allografts {#emmm201606674-sec-0019}
--------------------------------------------------

Serum was obtained from the KPC allograft‐bearing mice 5 days after treatment with either vehicle (control), 12 Gy, anti‐PD‐L1, or 12 Gy + anti‐PD‐L1. Serum was assessed for expression of cytokines using a standard Cytokine Profiler kit and SDF‐1 ELISA kit (both from R&D Systems) according to the manufacturer instructions. Array spot intensities were quantified using a Matlab software as reported (Zhao *et al*, [2013](#emmm201606674-bib-0056){ref-type="ref"}).

Mathematical modeling {#emmm201606674-sec-0020}
---------------------

We


and others have previously used mathematical modeling to describe T‐cell activation and antigen potency (Dushek *et al*, [2011](#emmm201606674-bib-0016){ref-type="ref"}; Lever *et al*, [2014](#emmm201606674-bib-0031){ref-type="ref"}; Tolaney *et al*, [2015](#emmm201606674-bib-0050){ref-type="ref"}). Here, we used the same principles to model the efficacy of anti‐PD‐L1 and RT in the different experiments. The mathematical model consists of a system of ordinary differential equations (ODEs), which are often used to describe the interactions among cellular populations in immunology and cancer,

∂T1/∂t = λ\*T1(resistant tumor cells)∂T2/∂t = λ\*T2‐ε1/((K+M))\*E\*T2‐ε2\*X\*T2(susceptible tumor cells)∂E/∂t = γ(CD8 effector T cells)∂X/∂t = β(other immune cells)∂M/∂t = φ(microenvironment factors)

where: λ = 0.19, γ = 0.025, β = 0.16, ε2 = 0.0298, M ≥ 1, K ≪ 1, tumor volume V = T1 + T2, and under the different treatment conditions: no treatment: ε1 = 0.002, φ = 3, T1 day 0 = 100, T2 day 0 = 0; radiation: ε1 = 0.002, φ = 3, T1 day 0 = 0.4, T2 day 0 = 99.6; radiation + anti‐PD‐L1 (day 0): ε1 = 0.02, φ = −0.2, T1 day 0 = 0.4, T2 day 0 = 99.6; radiation + anti‐PD‐L1 (day 6): ε1included. The primary indications for plasma transfusion were critical bleeding in 22.3%, minor bleeding in 21.2%, planned surgery or procedure in 11.7%, and high risk of postoperative bleeding in 10.6%. No bleeding or planned procedures were reported in 34.1%. Before plasma transfusion, the median international normalized ratio (INR) and activated partial thromboplastin time (aPTT) values were 1.5 and 48, respectively. After plasma transfusion, the median INR and aPTT changes were -0.2 and -5, respectively. Plasma transfusion significantly improved INR only in patients with a baseline INR greater than 2.5. One-third of transfused patients were not bleeding and had no planned procedure. In addition, in most patients, coagulation tests are not sensitive to increases in coagulation factors resulting from plasma transfusion. Studies assessing appropriate plasma transfusion strategies are urgently


In Norway, a Prison Built on Second Chances - user_235711
http://www.npr.org/sections/parallels/2015/05/31/410532066/in-norway-a-prison-built-on-second-chances
======
bsenftner
The US prison system is actually an industrialized slavery system for US
corporations. The prison system here has a "work program" for inmates where
they earn pennies per hour to manufacture products for US corporations.
Investigate how institutionalized this practice has become. We need to stop
this immediately, as it can and will spread unless we do. This is evil
unmasked.

[http://www.globalresearch.ca/the-prison-industry-in-the-
unit...](http://www.globalresearch.ca/the-prison-industry-in-the-united-
states-big-business-or-a-new-form-of-slavery/8289)
[http://www.alternet.org/story/151732/21st-
century_slaves%3A_...](http://www.alternet.org/story/151732/21st-
century_slaves%3A_how_corporations_exploit_prison_labor)
[http://www.forbes.com/2008/08/18/prison-small-business-
ent-m...](http://www.forbes.com/2008/08/18/prison-small-business-ent-manage-
cx_mf_0818prisonlabor.html)

~~~
notdanariely
I agree that this trend is disturbing, but am unable to reconcile your
alarmist language with the numbers in the links you provided.

I do not support private corporations (or even public good -- yes, I think the
chain gang days of old are similarly awful) making money off of prisoners.
However, from the articles you linked, some data:

* 2 million (2,000,000) inmates in federal/state/local prisons.

* 100 privatepotent anti-inflammatory effect of Mannich curcuminoids in an induced colitis model in a rat.

2. Results {#sec2-molecules-24-01546}
==========

2.1. Relation of Mannich Substrates to Naturally Occurring Curcuminoids {#sec2dot1-molecules-24-01546}
-----------------------------------------------------------------------

Recently, a library of a structurally diverse set of 47-membered Mannich curcuminoid was created via a powerful Mannich-3CR (M-3CR)/Claisen-Schmidt condensation sequence \[[@B20-molecules-24-01546]\]. Utilization of the Mannich protocol, including the assemblies of aromatic aldehydes, primary amines, and pentane-2,4-dione, led to the formation of various Mannich structures as valuable intermediates with two optionally variable diversity points. Their treatment with aromatic aldehydes constituted a symmetrically substituted heptadienedione back-bone furnishing the desired curcuminoid species via morpholinium chloroacetate-catalyzed Claisen-Schmidt condensation \[[@B20-molecules-24-01546],[@B23-molecules-24-01546]\]. Sythesis and NMR (nuclear magnetic resonance) analysis have been published earlier \[[@B20-molecules-24-01546]\]. Here, we focus on the anti-inflammatory effect of derivatives of naturally occurring curcumin ([Figure 1](#molecules-24-01546-f001){ref-type="fig"}A) two


composition of the rats bearing colitis ([Figure 3](#molecules-24-01546-f003){ref-type="fig"}B). Sever colitis represented an enlarged, oedematous submucosa with extended leukocyte infiltration even to muscularis propria ([Figure 3](#molecules-24-01546-f003){ref-type="fig"}B). These signs of acute colitis were milder in the treated animals by both C142 ([Figure 3](#molecules-24-01546-f003){ref-type="fig"}C), C150 ([Figure 3](#molecules-24-01546-f003){ref-type="fig"}D), or Infliximab ([Figure 3](#molecules-24-01546-f003){ref-type="fig"}E) showing reduced thickness of the submucosa and lower degrees of lymphoreticular infiltrate.

Initially, following TNBS treatment, animals showed symptoms of weakness, bloody diarrhea, and weight loss, while rats in the absolute control group gained weight ([Figure 4](#molecules-24-01546-f004){ref-type="fig"}A). By the end of the third day, rats with colitis lost 20% of their body weight, while controls increased their weight by 15%. Treatment either by curcuminoids (C142 *p* \< 0.01, C150 *p* \< 0.001) or Infliximab (*p* \< 0.001) almost preserved the initialQ:

Is it safer to use multiple RS-485 point to point connections compared to a daisy chain?

When wiring multiple RS485 slaves to a master equipped with a RS232/RS422/RS485 interface*: is it safer to wire multiple point to point connections from the hub with their own termination resistor, compared to using one socket on the hub and daisy chaining them all terminating with a single resistor? The spec seems to say daisy chaining is a "dumb" parallel hard-wire, and I wonder if one receiver couldn't freeze the bus or even damage it (meaning the interfaces) if a failure occurs.
*: the interface is a 8 or 16 ports industrial USB to RS232/RS422/RS485 converter, to be selected

A:

Whether you drive the chips in parallel or series, it's possible for a single failure (an


Angebote zu "Paradise" (3 Treffer)

Kategorien

Shops

Being an island of private powdery white beaches, secluded colonial bungalows in the heart of lush jungles, Green Grassy and Cold Mountains and luxurious star class suites in the city makes Sri Lanka an ideal choice for honeymoons and weddings. Many hotels specialized in honeymoons are opening offering newlyweds and couples to be the ideal getaway. Ayurveda, the authentic Sri Lankan spa treatment is gaining worldwide acknowledge and is ideal for honeymooners to relax.Expereince the best of tropical paradise with our 5 days honeymoon tour which will take you through the amazing sights of Sri Lanka and make your Honeymoon a remembrance for life timeus in a way that's very different from day to day*" (RN). This embeddedness ensures the program is part of usual care, rather than compartmentalized as something "extra": "*I didn't even know it was a program, I thought it was ingrained into clinical practice in the ICU.*" (Resident).

Description of variation across sites {#Sec5}
-------------------------------------

The main points of variation across centers related to the organizational context and resources with which the program was implemented. These differences created diverse foundations upon which local versions of 3WP were built.

### Organizational context {#Sec6}

Differences across participating sites provoked discussion of practical and logistical issues. For example, smaller centers with fewer staff members found it challenging to mobilize individuals to implement wishes due to competing clinical demands: "*We're so short-staffed, so I don't know how


university ... we actually utilize them a lot to help us gather supplies or to help us.*" (RN). Other resources had to be creatively sourced. Organizing financial resources required ingenuity, with teams securing funds from research grants, awards, fundraising among staff and the hospital community, and small corporate grants for supplies, as outlined in Table [3](#Tab3){ref-type="table"}. Several sites successfully tapped into resources beyond the ICU, such as musicians in the volunteer association. Others connected with groups such as school children who made blankets to comfort dying patients, forming ongoing relationships that benefitted both parties: "*The \[school\] board said 'yup, we love it, it's a great idea, but we in turn would like someone from the hospital to come and talk about death and dying and why the program is*
 * If a WR shutdown in SOCKETS_Shutdown() is invoked, this flag is
 * set in the socket's xShutdownFlags member.
 */
#define nxpsecuresocketsSOCKET_WRITE_CLOSED_FLAG    ( 1UL << 2 )

/**
 * @brief Flag indicating that socket receive operations are not permitted.
 *
 * If a RD shutdown in SOCKETS_Shutdown() is invoked, this flag is
 * set in the socket's xShutdownFlags member.
 */
#define nxpsecuresocketsSOCKET_READ_CLOSED_FLAG     ( 1UL << 1 )

/**
 * @brief Delay used between network select attempts when effecting a receive timeout.
 *
 * Timeouts are mocked in the secure sockets layer, and this constant sets the
 * sleep time between each read attempt during the receive timeout period.
 */
#define nxpsecuresocketsFIVE_MILLISECONDS           ( pdMS_TO_TICKS( 5 )


   {
                    memcpy( pxContext->pcDestination, pvOptionValue, xOptionLength );
                    pxContext->pcDestination[ xOptionLength ] = '\0';
                }

                break;

            case SOCKETS_SO_TRUSTED_SERVER_CERTIFICATE:

                /* Secure socket option cannot be used on connected socket */
     Q:

How can I quickly scale and sharpen an image in Go?

I'm currently porting a pretty basic gallery application from PHP to Go. This application features automatic generation of thumbnails and middle-sized version of every image.
In PHP I used GD, because it ships with it and worked pretty well. (Code is at the end of the question). I thought I could just replicate that in Go and found go-gd from https://github.com/bolknote/go-gd (again, code is at the end). It works, but it is roughly 10 times slower (measured using time wget $URL). The PHP implementation takes about 1 second for generating a 1024x768 version from a 10 MP-image, while the Go-Code takes almost 10 seconds.
Is there any way to speed this up or any other image-processing libary for Go, which


  var targetX, targetY int = 0, 0

    if options.KeepAspect {
        factor := math.Fmin(float64(options.SizeX)/float64(image.Sx()), float64(options.SizeY)/float64(image.Sy()))
        targetX = int(factor*float64(image.Sx()))
        targetY = int(factor*float64(image.Sy()))
    } else {
        targetX = options.SizeX
        targetY = options.SizeY
    }
    tmpImage := gd.CreateTrueColor(targetX, targetY)
    image.CopyResampled(tmpImage, 0, 0, 0, 0, tmpImage.Sx(), tmpImage.Sy(), image.Sx(), image.Sy())

    if options.Sharpen {
        sharpenMatrix := [3][3]float32{
        {-1, -1.7, -1},
       = BIOS_CNTL_REG_NEW;
	}

	pci_read_config_byte(dev, intel_rng_hw->fwh_dec_en1_off,
			     &intel_rng_hw->fwh_dec_en1_val);
	pci_read_config_byte(dev, intel_rng_hw->bios_cntl_off,
			     &intel_rng_hw->bios_cntl_val);

	if ((intel_rng_hw->bios_cntl_val &
	     (BIOS_CNTL_LOCK_ENABLE_MASK|BIOS_CNTL_WRITE_ENABLE_MASK))
	    == BIOS_CNTL_LOCK_ENABLE_MASK) {
		static __initdata /*const*/ char warning[] =
			KERN_WARNING PFX "Firmware space is locked read-only. "
			KERN_WARNING PFX "If you can't or\n don't want to "
			KERN_WARNING PFX "disable this in firmware setup, and "
			KERN_WARNING PFX "if\n you are certain that your "
			KERN_WARNING PFX "system has a functional\n RNG, try"
			KERN_WARNING PFX "using the 'no_fwh_detect' option.\n";

		if (no_fwh_detect)
			return -ENODEV;
		printk(warning);
		return -EBUSY;
	}

	intel_rng_hw->mem = ioremap_nocache(INTEL_FWH_ADDR, INTEL_FWH_ADDR_LEN);
	if (intel_rng_hw->mem == NULL)
		return -EBUSY;

	return 0;
}

static int __init mod_init(void)
{
	int err = -ENODEV;
	int i;
	struct pci_dev *dev = NULL;
	void __iomem *mem = mem;
	u8 hw_status;
	struct intel_rng_hw *intel_rng_hw;

	for (i = 0; !dev && pci_tbl[i].vendor; ++i)
		dev = pci_get_device(pci_tbl[i].vendor, pci_tbl[i].device,
				     NULL);

	if (!dev)
		goto out; /* Device not found. */

	if (no_fwh_detect


< 0) {
		pci_dev_put(dev);
		goto fwh_done;
	}

	intel_rng_hw = kmalloc(sizeof(*intel_rng_hw), GFP_KERNEL);
	if (!intel_rng_hw) {
		pci_dev_put(dev);
		goto out;
	}

	err = intel_init_hw_struct(intel_rng_hw, dev);
	if (err) {
		pci_dev_put(dev);
		kfree(intel_rng_hw);
		if (err == -ENODEV)
			goto fwh_done;
		goto out;
	}

	/*
	 * Since the BIOS code/data is going to disappear from its normal
	 * location with the Read ID command, all activity on the system
	 * must be stopped until the state is back to normal.
	 *
	 * Use stop_machine_run because IPIs can be blocked by disabling
	 * interrupts.
	 */
	err = stop_machine_run(intel_rng_hw_init, intel_rng_hw, NR_CPUS);
	pci_dev_put(dev);
	iounmap(intel_rng_hw->mem);
	kfree(intel_rng_hw);
	if (err)
		goto out;

fwh_done:
	err = -ENOMEM;
	mem = ioremap(INTEL_RNG_ADDR, INTEL_RNG_ADDR_LEN);
	if (!mem)
		goto out;
	intel_rng.priv = (unsigned long)mem;

	/* Check for Random Number Generator */
	err = -ENODEV;
	hw_status = hwstatus_get(mem);
	if ((hw_status & INTEL_RNG_PRESENT) == 0) {
		iounmap(mem);
		goto out;
	}

	printk(KERN_INFO "Intel 82802 RNG detected\n");
	err = hwrng_register(&intel_rng);
	if (err) {
		printk(KERN_ERR PFX "RNG registering failed (%d)\n",
		       err);
		iounmap(mem);
	}
out:
	return err;

}

static void __exit mod_exit(void)
{
	void __iomem *memMonday Morning CS Fan Boobs

Looks as if we have some fans of Crazy Shit right here folks. I would like to thank you ma'am for the lovely titties and you sir for so kindly snapping a picture of them and sending them into us. Ladies, do you have a set of tits you have yet to share with us? Write CS or Crazy Shit on them and Send In Your Boobs Now!


etched, whereby the conductor pattern 5 is formed. On this occasion, the respective conductors in the conductor pattern 5 can be formed with a width as small as about 0.5 mm.
However, if a conductor pattern including narrower conductors is desired, the respective conductors may be formed with a width as narrow as about 2 .mu.m by using well-known photolithography. A conductor pattern including very fine conductors can be applied to a large scale integrated circuit (LSI) device or a high frequency circuit having a large number of connection pins.
If resistors are incorporated in a conductor pattern, those resistors can be formed by printing and baking a pattern of a resisting coating material on the substrate 1 by a screen process.
Further, an interfacial insulating layer of polyimide or thecan get sum $2$? That is possible only as $1+1$, which by reasoning above can happen $2$ times (we have to pick two same numbers), so probability is $$p(2)=\frac{2}{132}=\frac{1}{66}$$
In how many ways can we get sum $3$? We have $3=1+2=2+1$ and again by reasoning above there is overall $4+4=8$ possibilities. This is because to get $2+1$ we need to pick two different numbers (and we know that is possible in $4$ ways), same for $1+2$. So probability is $$p(3)=\frac{8}{132}=\frac{2}{33}$$
Similarly $4=1+3=2+2=3+1$ with $4+2+4=10$ possibilities, so probability is $$p(4)=\frac{10}{132}=\frac{5}{66}$$
And so on...

A:

Here's a formula that generalizes to more digits.
Let's label the dice A and B, and write $(i,j)$ for the getting $i$ on A and $j$ on $B$. Consider the following two cases.

$i=j$. This can only happen if we


Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied.

Alamut

Prince Aidan, born of a royal father and a sorceress, vows to destroy his nephew's killer. But Aidan does not foresee a beautiful and immortal assassin with great power, greater than his own, or that she would speak to the sacred places in his heart.

Abstract:

Prince Aidan, born of a royal father and a sorceress, vows to destroy his nephew's killer. But Aidan does not foresee a beautiful and immortal assassin with great power, greater than his own, or that she would speak to the sacred places in his heart.

"Prince Aidan, born north of the US border on Route 203.
Domaine-Enchanté () – a cottage community just west of Covey Hill situated on the north shore of Lac-Enchanté.
Projet-Laplante () – a hamlet located  west of Covey Hill.
Russeltown Flats () – a hamlet located in the northern portion.
The Fort () – a hamlet located in the southeast portion on Route 202.

Lakes & Rivers
The following waterways pass through or are situated within the municipality's boundaries:
Lac Enchanté () – a lake situated  north of the US border.
Le Gouffre () – a small lake southwest of Lac Enchanté.

Topographic Features
Covey Hill () – a mountain situated west of the hamlet of Covey Hill. At , it is the highest point in Le Haut-Saint-Laurent.

Demographics

Population

Language

Arts and culture
The town is noted for its annual agricultural fair,


               \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$h$$\end{document}$ and *k*~B~ the Planck and Boltzmann constants, and $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                   \begin{document}$${\mathcal{S}}(\alpha T,\lambda )={\alpha }^{4}{\mathcal{S}}(T,\alpha \lambda ).$$\end{document}$$This equation means that the log--log plot representation of $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
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  \begin{document}$${\nu }_{\lambda }(T,\lambda )$$\end{document}$ describes the local nonlinearity exponent of $\documentclass[12pt]{minimal}
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      \begin{document}$$I(x,y)$$\end{document}$, that is, with no change of heat capacity and no phase transition. Also, the spectral emissivity will be considered to be invariant with temperature. Finally, a change of the target temperature may cause a variation of the spectral emissivity and thermal expansion. The emissivity comes as a wavelength-dependent pre-factor of the Planck spectrum, which possibly varies with temperature, although very smoothly. Emissivity was therefore assumed to be unity at all wavelengths. For most solid materials, expansion coefficients are typically $\documentclass[12pt]{minimal}
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                \begin{document}$$(x,y)$$\end{document}$, we assume that the object       \usepackage{amsbsy}
                \usepackage{mathrsfs}
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                \begin{document}$$\le \Delta {T} \le \Delta T_{\mathrm{max}}=$$\end{document}$ 100 K), for different values of the maximum integration wavelengths $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}


             \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$$\Lambda \ll {\lambda }_{\mathrm{max}}({T}_{\mathrm{ref}})$$\end{document}$, that is, when the spectral radiance becomes dramatically weak. Therefore, the photon budget must be assessed to optimize the trade-off between the detection sensitivity and the resolution.

Photon budget and suggested conditions for super-resolved detection {#Sec5}
-------------------------------------------------------------------

For the sake of the present argument, we consider a beam scanning excitation scheme and a target object that contains details smaller than the beam cross-section. The thermal signal is not imaged, but is collected instead with a point detector, for each position $\documentclass[12pt]{minimal}
    \begin{document}$$\Delta {{\mathcal{C}}}_{\mathrm{max}}$$\end{document}$ twice larger than the previous line.

Obviously, the integration time matters tremendously, as well as the optical étendue $\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}


         \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$${T}_{\mathrm{ref}}=$$\end{document}$300 K) in Table [1](#Tab1){ref-type="table"}. A              \usepackage{upgreek}
                \setlength{\oddsidemargin}{-69pt}
                \begin{document}$${\mathcal{S}}_{W}(T,\lambda )=\frac{hc}{\lambda }{\mathcal{S}}(T,\lambda )$$\end{document}$. The reason is that quantum detector offer better performances than classical detectors for low light level applications, but a similar analysis can be made for the power spectral radiance, which leads to a slightly smaller but still quite significant superlinearity. We should also mention here that new quantum detectors, such as superconducting nanowire single-photon detectors, or HgCdTe avalanche photodiodes, could be instrumental to implement the ideas presented in this paper. HgCdTe avalanche photodiodes for instance provide indeed outstanding


pneumonia we have identified that both course and outcomes are poorer for bacteremic patients while they show a similar severity of illness on admission. There is one previous study with the same design and similar results; the differences observed in the mortality were not, however, adjusted for host-related factors or antibiotic treatment \[[@B18]\]. Others strengths of this study are its prospective design, identification of cases based on clinical diagnosis, relatively large sample of non-selected patients, comprehensive assessment of outcomes, detailed collection of clinical data, and use of a robust risk-adjustment model.

When comparing characteristics of two groups of patients, the similarities rather than the differences are initially what are most important. In our study, patients were similar in age, level of comorbidity, and severity of illness on admission. Observed"Good evening." "I'm deeply moved." "Good evening." "Good evening." "I don't understand." "Good evening." "Howdy, Mr. goodson." "As one colleague to another, have you ever seen reference to blackmail in the good book?" "I'm delighted to welcome you here." "To commemorate this occasion," "I think we should sing a hymn which has special meaning to me-- shall we gather at the river." "?" "Shall we gather at the river ?" "?" "where white angel feet have trod ?" "?" "with its crystal tide forever ?" "?" "flowing by the throne of god ?" "?" "yes, we'll gather... ?" "Roust 'em out, Clayboy." "Happy graduation day, son !" "Rise and shine." "Sun's up." "Come on." "Come on, you guys." "Get dressed for my graduation." "Come on." "Come on, Becky,


it a vacation if I could sit down for 10 minutes on that porch." "Sure you can't stay to supper?" "No." "First night home." "Daddy will be" "Here." "I'll take care of Donnie." "You go on out and look at the sunset with Clayboy." "Guess what." "Your parents are taking a second honeymoon." "We'll be papa and mama while they're gone." "What do you think about that?" "What do I think?" "I think you're crazy." "Here's a dictionary with all the naughty words underlined." "Oh, I've seen all those." "Look at this one." "Holy smoke." "How did you find them?" "Study hours." "Look at that." "Soon as you find out what they mean, erase the underline." "I know them all by heart anyway." "Look up "friction."" "The girlsmay concern," ""this certifies that Clay Spencer Jr." ""Has completed the equivalent" ""of one college semester in Latin," ""passing final examination" ""with a grade of 95." "Clyde goodson."" "Please place this in the Clay Spencer Jr. file, then add his name to the roster of the freshmen class entering on the 10th." "Don't he have to talk Latin to you?" "Goodson's endorsement's enough." "By the way, neighbor Spencer, is he a good preacher?" "Well, I've been a heathen all my life, and he's got me sitting in the amen corner on Sunday." "Converted you, huh?" "Hell, no." "That's what he charged for giving my boy lessons." "Come see me when you enroll next week." "Thank you, sir." "You were able to raise the money?" "All I needed was


the new approach is very adaptive. A common problem that renders standard chemotherapies ineffective is that the cancer cells evolve to generate new mutations. Using genome editing, the new mutations could be targeted to continue fighting the disease, Luo noted.

In the future, the researchers plan to test whether this strategy could completely eradicate the disease rather than induce the partial remission observed in the current study.

Additional authors include: Zhang-Hui Chen, Ph.D., Yan Yu, M.D., Ph.D., Ze-Hua Zuo, Ph.D., Joel Nelson, M.D., George Michalopoulos, M.D., Ph.D., Satdatshan Monga, M.D., Silvia Liu, B.S., and George Tseng, Sc.D., all of Pitt.

Cancer cell line with CRISPR-based gene therapy delivered via viruses.week, we talked with The Document Foundation's marketing assistant Mike Saunders about the 1 million downloads milestone reached by the major LibreOffice 6.0 release in only two weeks after its launch, who told us that the team is already working on the next version, LibreOffice 6.1, due for release in August.

LibreOffice 6.1 will be the first major update to the 6.x series of the office suite and will add yet another layer of new features and improvements to the open-source and cross-platform office suite used by millions of computer users worldwide, and we'd like you to be the first to know about them.

Microchip unveiled an open source, mainline Linux ready “SAMA5D27 SOM” module based on a SiP implementation of its Cortex-A5-based SAMA5D27 SoC with 128MB RAM. The 40


a question many games, films and books have covered in great detail. The Station [Steam] is a sci-fi mystery that sees you investigate The Espial, a space station sent to research a sentient alien civilization.

The last months for Kdenlive have been very quiet from the outside – we were not very active on the bugtracker, did not make a lot of announcements, and the 17.12.x release cycle only contained very few minor bugfixes.

The main reason for this was the huge work that went behind the scenes for a major code refactoring that was required to allow further developments. So after more than a year working on it, we hope to get ready for the 18.04 release!

I did Archaeology in University and I love history, mythology, folklore and nature.however, isn't really well suited for newer users...hence the explosion of distros based on Debian over the recent years. There are lot of great choices for Linux users. Which one is best for you?

Compact, rugged IoT gateway offers dual GbE with PoE

Inforce has launched a $250 “Inforce 6320” IoT gateway that runs Linux on a quad -A53 Snapdragon 410, and offers WiFi, BT, GPS, HDMI, USB, -30 to 85°C support, and dual GbE ports with PoE.
Inforce Computing’s $250 Inforce 6320 is a compact (170 x 95 x 42mm) IoT gateway that runs Ubuntu Core (Snappy) and Debian on Qualcomm’s Snapdragon 410E. Inforce promises “periodic upstream kernel based BSP releases [that] include in-depth documentation along with a host of royalty-free software.” The Debian BSP includes LXDE, drivers for all


Q:

Excel VBA: inserting WHEN formula into specific range of cells with variable changing column

Hello dear StackOverflow users,
My issue is regarding inserting a Formular via Macro into specific range of cells. Again, again and again.
So the Basic function of the formula should be the following:
=WHEN('ZEK '!F3="X";"6";WHEN('ZEK '!G3="X";"8";"1"))
In my macro it has to Change the column for the next specific range.
This is Happening in a for Loop for i growing.
meaning --> =When('ZEK '!$F$"& i+2 &".......
or in any other Syntax that should work. My try fairly does not, thats why I need your help.
This is my Initial try where i exchanged literally everything with strings:
Sub 123()
Dim a,b,c As String
a = 1
b = 6
c = 8

....

'used and declared variables k, x, f, a, b, c

Range(Cells(k + 2, 5), Cells(k + 27, 5)).FormulaR1C1line set up. Here are some tips for early levels:

Prior to level 40 and the Tier 2 line, put points in the trees in this order Spite -> Blood Magic -> Curses. Afterwards, focus on Blood Magic to 20 points and then finish out the Spite tree all the way to 30. Grabbing Vampiric is a must as soon as possible for the constant health leeching.

Grab Well of Suffering and Bone Minions as your early utility skills. The Putrid Explosion from the minion does very nice damage and will last a long time while you level up and get the other skills.

Use warhorn effectively and will save your life a LOT! Gathering up mobs and dazing them gives you time to put up Locust Swarm so you get


ticks of health with Vampiric and plenty of damage going around.

I used this build from level 1 all the way through 80. The mobs in the early zones (1-25 or so) are easy to kill even without a robust trait line set up. Here are some tips for early levels:

Prior to level 40 and the Tier 2 line, put points in the trees in this order Spite -> Blood Magic -> Curses. Afterwards, focus on Blood Magic to 20 points and then finish out the Spite tree all the way to 30. Grabbing Vampiric is a must as soon as possible for the constant health leeching.

Grab Well of Suffering and Bone Minions as your early utility skills. The Putrid Explosion from the minion does very nice damage andwill last a long time while you level up and get the other skills.

Use warhorn effectively and will save your life a LOT! Gathering up mobs and dazing them gives you time to put up Locust Swarm so you get ticks of health with Vampiric and plenty of damage going around.

In another thread you mentioned swapping out bone minions with BiP, are you recommending that switch for your build above?

In another thread you mentioned swapping out bone minions with BiP, are you recommending that switch for your build above?

Remains to be seen... someone presented some math to show that over 1 minute BM damage is MUCH higher but based it on base level bleed damage with no condition damage included. I am not a theorycrafter, but I am


in a power build for necros, may I know why you dont have it ( i see you updated your post the first of october)

Sorry if I missed it somewhere, still new to all this, my highest char is lvl 2.

Tips are more then welcome aswell!

As for the rest, kudos to the guide, itll be the one Ill most likely follow if I decide to be a necro

We've been having a little debate on whether Blood is Power is actually beneficial in it's numbers compared to Putrid Explosion (the secondary ability from Bone Minions) - http://www.guildwars...ith-the-design/

Short version - over a one minute period you do 9,552 damage with the Explosion compared to 6,260 damage from Blood is Power's bleed. However, my argument is the cumulative effect of thedo rely on crits for procs on sigils, etc. But if it's not worth it, there are definitely lines that seem to synergize with the build better.

If you drop the 20 points in Curses, thereby losing 200 precision, you lose 9.45% crit rating. Depending on your current crit rate this is either not too major or it's gonna hurt. I am trying to keep 45%+ on my crit rate right now and not go below that.... crits are a big part of your overall damage as a powermancer.

I think, in the end, it's up to you and your playstyle with the build. Going in to Soul Reaping would be a nice benefit for DS and going in to Death Magic is great for defensive abilities from wells. Keeping


career
Katzmann began his legal career in the office of Richard S. Dow. He later opened his office with his brother Percy A. Katzmann in Hyde Park. The two opened a second office in Boston and in 1905 former district attorney Thomas E. Grover joined the firm. In December 20, 1909 he was appointed as an assistant district attorney for the southeastern district (Norfolk and Plymouth counties).

On January 3, 1917 Katzmann was sworn in as district attorney. In 1921 he prosecuted Nicola Sacco and Bartolomeo Vanzetti for armed robbery and the murder of a security guard and paymaster during an armed robbery. Sacco and Vanzetti were found guilty and executed. Katzmann left office in 1923 and returned to private practice. However, he remained involved in later phases the SaccoNow

National Day to Prevent Teen Pregnancy

First published online: May 3, 2006

May 3 is the National Day to Prevent Teen Pregnancy, when teens around the country are asked to stop, think and take action to prevent unintended pregnancy. Although the rate of teen pregnancy in the United States dropped by more than 25% during the 1990s, more than 800,000 U.S. teens still become pregnant each year, and eight in 10 of these pregnancies are unintended.

The good news is that many teens are waiting longer to have sex and using contraceptives more consistently and more effectively. Yet a recent study by the Guttmacher Institute shows that many states are failing to support young people in these healthy choices, by failing to provide teens with adequate contraceptive information and services.

For example,


1 at 6), stands on a different footing. See Fox v. Lappin, 441 F.Supp.2d 203, 207 (D.Mass.2005) ("Notification does not relate to a prisoner's conditions of confinement but affects life upon release from prison."). First, the notification challenge is not properly a habeas action. See id. at 206 ("Notification claims do not relate to the fact or duration of confinement, therefore challenge to a notification requirement is not properly brought as a habeas petition."). If the Court bypasses this problem, and construes Golden's claim as an action under the Administrative Procedure Act ("APA"), 5 U.S.C. § 551 et seq., see id. at 207, this claim would arguably continue to present a live controversy. Nevertheless, the claim is moot for another reason: the BOP has decided in Golden's favorindicated that failure to comply with Rule 72(b), Fed.R.Civ. P., shall preclude further appellate review. See Keating v. Secretary of Health and Human Services, 848 F.2d 271 (1st Cir. 1988); United States v. Emiliano Valencia-Copete, 792 F.2d 4 (1st Cir.1986); Scott v. Schweiker, 702 F.2d 13, 14 (1st Cir.1983); United States v. Vega, 678 F.2d 376, 378-379 (1st Cir.1982); Park Motor Mart, Inc. v. Ford Motor Co., 616 F.2d 603 (1st Cir.1980); see also Thomas v. Arn, 474 U.S. 140, 106 S.Ct. 466, 88 L.Ed.2d 435 (1985).
NOTES
[1]  On February 28, 2008, the district judge to whom this case is assigned referred Respondent's Motion to Dismiss or, in the alternative, for Summary Judgment (# 6) to this Court for a Report and Recommendation.
[2]  By letter dated June


2012 Idol Star Athletics – Swimming Championships

The 2012 Idol Star Athletics – Swimming Championships (Hangul: 아이돌 스타 육상-수영 선수권 대회) was held at Jamsil Arena in Seoul, South Korea on January 8, 2012 and was broadcast on MBC on January 24, 2012 (2 episodes). At the championships a total number of 10 events in athletics and 2 events in swimming were contested: 6 by men and 6 by women. There were a total number of 150 participating K-pop singers and celebrities, divided into 16 teams.

Results

Men

Athletics

Swimming
Special appearance and swimming performance by Choi Kyu-woong.

Women

Athletics

Swimming

Ratings

References

External links
2012 Idol Star Athletics-Swimming Championships official MBC website

Category:Munhwa Broadcasting Corporation television programmes
Category:South Korean variety television programmes
Category:South Korean game shows
Category:2012 in South Korean televisionLaw with 10 000 irises hanging from the ceiling
We are building a new neighbourhood at Greenwich Peninsula
the art gallery is part of the place-making agenda that we're doing here
so it's fine art, fashion and design
there's a golf range as well
Oh, if you're wondering, L&Q are one of the largest providers  of quality shared ownership homes in London
now watch this drive
You play a Slazenger 4, don't you?
You must have played the wrong ball somewhere on the last fairway
I own the club Mr. Bond
So over there in the distance you can see the Thames Barrier
it was built in 1982. It's got 10 flood gates, all abreast
Do you think they're supposed to look like the sails of ships?
Is that why they're designed like that? A bit like the Sydney Opera


House.
It's a bit further than it looks though.
I did walk it yesterday and I'm not doing that again
In order to stop the urban sprawl taking over
they've got this little ecology park
It's supposed to help with the flourishment of
species like dragon flies...
Bats, cleavers....
I thought it said cleavage for a second
It's really serene actually
L&Q wanted me to mention they've got more shared ownership homes coming up in 2018 in London and the southeast
one of which is over towards the old town of Greenwich
and I'm really looking forward to going over there because it's one of my favourite parts of London
the staff on here are so much more jolly than on on the underground
This is great fun
I mean, it doesn't look quite like Venice but
These are known as gondolas
Excellent
That took aboutMC records, numbers of deaths from alcohol-related chronic UC (2006-2010) were 81% of ARDI estimates for age 20-64, but only 40% for 65+ years. The MC records identified substantial numbers of deaths from causes (e.g. certain infectious diseases) not included as alcohol-related in ARDI, but included in surveillance of premature death rates for chronic UC. Also, premature death rates for chronic alcohol-induced causes using only the UC (as in routine mortality statistics) were only about half the rates based on MC; all rates increased in recent years but some reached statistical significance only by using MC. Using MC records underestimated total US deaths from alcohol-related chronic causes as the UC, but enhanced surveillance of rates for premature deaths involving chronic causes that may be related to excessive alcohol


of a Profit Sharing Plan and Trust (the "trust").
2. On September 11, 1987, the debtor filed a voluntary petition for relief under Chapter 7 of the Bankruptcy Code. 11 U.S.C. § 101 et seq. Scott W. Putney, Trustee, Inc. was named as bankruptcy trustee.
3. The debtor, as part of the petition, filed Schedule B-4, Property Claimed as Exempt, and claimed, among other things, his interest in the trust as exempt property. On November 20, 1987, the trustee filed an objection to debtor's claim of exemption arguing that the interest in the trust is property of the estate.
4. The relevant portions of the Profit Sharing Plan and Trust provide:
NONALIENATION OF BENEFITS.  Any benefits payable under this plan shall not be subject in any manner to anticipation, alienation, sale, define BOOST_NO_CV_VOID_SPECIALIZATIONS
#  endif

//
// If there is no numeric_limits template, then it can't have any compile time
// constants either!
//
#  if defined(BOOST_NO_LIMITS) \
      && !defined(BOOST_NO_LIMITS_COMPILE_TIME_CONSTANTS)
#     define BOOST_NO_LIMITS_COMPILE_TIME_CONSTANTS
#     define BOOST_NO_MS_INT64_NUMERIC_LIMITS
#     define BOOST_NO_LONG_LONG_NUMERIC_LIMITS
#  endif

//
// if there is no long long then there is no specialisation
// for numeric_limits<long long> either:
//
#if !defined(BOOST_HAS_LONG_LONG) && !defined(BOOST_NO_LONG_LONG_NUMERIC_LIMITS)
#  define BOOST_NO_LONG_LONG_NUMERIC_LIMITS
#endif

//
// if there is no __int64 then there is no specialisation
// for numeric_limits<__int64> either:
//
#if !defined(BOOST_HAS_MS_INT64) && !defined(BOOST_NO_MS_INT64_NUMERIC_LIMITS)
#  define BOOST_NO_MS_INT64_NUMERIC_LIMITS
#endif

//
// if member templates are supported then so is the
// VC6 subset of member templates:
//
#  if !defined(BOOST_NO_MEMBER_TEMPLATES) \
       && !defined(BOOST_MSVC6_MEMBER_TEMPLATES)
#     define BOOST_MSVC6_MEMBER_TEMPLATES
#  endif

//
// Without partial specialization,


  define BOOST_NO_STD_USE_FACET
#  endif

//
// We can't have a std::messages facet if there is no std::locale:
//
#  if defined(BOOST_NO_STD_LOCALE) && !defined(BOOST_NO_STD_MESSAGES)
#     define BOOST_NO_STD_MESSAGES
#  endif

//
// We can't have a working std::wstreambuf if there is no std::locale:
//
#  if defined(BOOST_NO_STD_LOCALE) && !defined(BOOST_NO_STD_WSTREAMBUF)
#     define BOOST_NO_STD_WSTREAMBUF
#  endif

//
// We can't have a <cwctype> if there is no <cwchar>:
//
#  if defined(BOOST_NO_CWCHAR) && !defined(BOOST_NO_CWCTYPE)
#     define BOOST_NO_CWCTYPE
#  endif

//
// We can't have a swprintf if there is no <cwchar>:
//
#  if defined(BOOST_NO_CWCHAR) && !defined(BOOST_NO_SWPRINTF)
#     define BOOST_NO_SWPRINTF
#  endif

//
// If Win32 support is turned off, then we must turn off
// threading support also, unless there is some other
// thread API enabled:
//
#if defined(BOOST_DISABLE_WIN32) && defined(_WIN32) \
  you the question: 'Why did you participate in an illegal meeting of dwarfs?'"21 In spite of their sense of humor, Orange Alternative's members were very serious in their endeavors to present Polish citizens with a way of protesting peacefully. They managed to do this by allowing people to regain political agency via the transgressive power of artistic play for social and political change. Through texts such as the Manifesto of Socialist Surrealism (1980), they managed to promote a keen sense of humor that could provide the public sphere with a much-needed self-disciplining agency; if dwarfs could do it, the people will do it! "Pure Rationalism failed to dominate toilets. Surrealism was kept alive in toilets thanks to the politicians [...] The politicians have always been great surrealists."22 Throughout


history governments were frequently trying to ban theatre and other acts of performance, because they believed that the performative genre were capable of spreading and encouraging rebellions against the established order. It is so because performance enables an evaluation of the ways in which individuals act and react in the world, for themselves and for others. From Turner's concept of social drama (1957) to Goffman's dramaturgical model of everyday behavior (1959), anthropological approaches to performance reveal how events, rituals and daily life are governed by a code of performance. Likewise, the notion of performativity (including Butler's "gender performativity,") as a study on the discourse used in identity formation, as well as the performative arts in general, are associated with ideologies connected with performativity in everyday social life. Althusser'sAlternative's actions can be regarded as the pioneers of guerrilla communication and carnival resistance, also commonly practiced in contemporary political protest. CONTEMPORARY REFLECTIONS Orange Alternative's influence on contemporary forms of political protest is undeniable, while their socialist surrealism remains a remarkably artistic form of nonconformist philosophy. With their absurdist yet highly complex social acts, the group's surrealist artistic activism represents a bridge across the Ukrainian Orange Revolution (2004–2005) and the most recent Pastafarian Church of the Flying Spaghetti Monster (FSM). Likewise, it cannot be a mere coincidence that The Yes Men of the United States-creative activists who perform nonviolent resistance by misleading American mainstream media, as well as pulling pranks on major corporations-wrote a foreword to the autobiography by Fydrych, Lives of the Orange Men-A Biographical History of


title of individual plots within the area, the entire block retains its reservation status until Congress explicitly indicates otherwise.") (citation omitted). "[C]ongressional intent must be clear, to overcome `the general rule that [d]oubtful expressions are to be resolved in favor of the weak and defenseless people who are the wards of the nation, dependent upon its protection and good faith.'" DeCoteau, 420 U.S. at 444, 95 S.Ct. 1082 (quoting McClanahan v. Ariz. State Tax Comm'n, 411 U.S. 164, 174, 93 S.Ct. 1257, 36 L.Ed.2d 129 (1973)) (further quotation and internal quotation marks omitted). "The `traditional solicitude for the Indian tribes,' however, precludes the courts from diminishing Indian lands without `substantial and compelling evidence of a Congressional intention' to exercise its power to diminish Indian lands." Absentee Shawnee Tribe,the court's decision, but is not its lone impetus.
In sum, the court is not persuaded by the Tribe's arguments. The plain language *1192 and structure of the 1854 Treaty indicate an intent to transfer all of the Shawnee reservation to the United States, effectively terminating the reservation. The United States then gave members of the Tribe the opportunity to choose allotments from 200,000 acres of the former reservation. Such conveyance was ineffective to reestablish a reservation previously terminated.

b. Surrounding Circumstances and Legislative History
The surrounding circumstances and legislative history also support a determination that Congress intended to terminate the Shawnee reservation when it ratified the 1854 Treaty. The court will examine these two factors together, as they are intertwined in this case.
In DeCoteau, the Supreme Court held that "`the


in this case, there is little, if any, evidence of the intent of the government and the Tribe at the time they signed the treaty. The only evidence available centers on the months before Commissioner Manypenny reached an agreement with the Tribe.
In 1853, Congress authorized the President of the United States to negotiate with the Indian tribes west of Missouri and Iowa "for the purpose of `securing the assent of said tribes to the settlement ... upon the lands claimed by said Indians, and for the purpose of extinguishing the title of said Indians, in whole or in part, to said lands...'" Absentee Shawnee Tribe, Dkt. 334, Ind. Cl. Comm., at 379 (quoting 10 Stat. at 238). Pursuant to this authority, the President designated Commissioner Manypenny to conductissue whether, by law, the SFAAP fell within a Shawnee reservation.
The Tribe next contends that the language in several pieces of legislation reinforces the continued existence of the Shawnee reservation. Section 19 of the 1854 Organic Act provides in part:
That nothing in this act contained shall be construed to impair the rights of person or property now pertaining to the Indians in said territory, so long as such rights shall remain unextinguished by treaty between the United States and such Indians, or to include any territory which, by treaty with an Indian tribe, is not, without the consent of said tribe, to be included within the territorial limits or jurisdiction of any state or territory; but all such territory shall be excepted out of the boundaries, and constitute


and self-love are issues that are often related together. Your belief is that you are not good enough to be loved. If you perceive yourself as a failure, weak or stupid, mustering love for yourself can be very difficult. You are not able to embrace yourself unconditionally.

Learn How to Love Yourself Unconditionally

Learning how to love yourself may feel unnatural for a start since you could have been ingrained with negative beliefs for decades. It has to be learnt – in other words, in the form of a practice.

However, nothing is going to happen if you do not FIRST make a conscious decision. By not loving yourself adequately, you are basically telling the Universe that you are unworthy or undeserving of any love or positive outcomes that have thesame vibrational match as love. Indeed, inadequate self-love can make it difficult to attract relationships, all the things you would love in your life….which sums up to abundance. You can find it nearly impossible to ever reach your highest potential!

Learning how to love yourself starts with knowing that you do have a choice. And it is up to you to consciously make the decision of loving yourself. The choice to make is clear: to love yourself unreservedly, without apology and in every way! (As one of my clients proclaimed upon awakening to self-love, “but of course…why would I choose otherwise?”)

Your intention is to be happy, love yourself and lead a fulfilled life. By making the conscious decision, you are really saying that you want to come alive. You


praise yourself everyday, while in the front of the mirror. Because of such thoughts, you naturally undertake empowering actions that support your development.

4. Acknowledge Your Effort. It is not always about winning or coming up tops in everything that you do. Many times, it is the effort that counts! Acknowledge that you have done your best, even if you have failed to produce tangible results.

5. Let Go Of Worry. Loving yourself requires you to let go of your worry. It is a horrible way to live a life filled with constant worrying. I can attest to that! Worry does not help in any way. It cannot, on its own, make things happen. Only wise actions can! So instead of worrying, spend time thinking about what you can doLavandaie, a small alley where Milanese woman used to wash clothes in the Naviglio's waters.

While Porta Genova is one of the most old-fashioned districts in Milan, and it is strongly connected to the tradition. It is also extremely popular with the Milanese youth, both for the  night-life (especially along the banks of the Naviglio) and its anti-comformist atmosphere. This reflects, for example, in the almost ubiquitous street art works, the numerous" alternative" shops, as well as the peculiar character of the main street market of the area, the Fiera di Senigallia, which is renowned as one of the best places in Milan where to look for unusual, rare and bizarre merchandise.

See also
 Porta Genova (Milan Metro)

References

Category:Districts of Milan
Category:Entertainment districts in Italy


In the medical arts, it is common practice to affix a rod to a patient's spine in order to immobilize the spine in its length adjacent the affixed rod. In that practice, the surgeon determines the necessary length and configuration of a rod which is to be implanted into the patient, and that determination is based upon utilizing a template rod which the surgeon initially configures to the shape of the length of the spine which is to immobilized. That is, the surgeon initially bends and measures a bendable rod to conform to the affected part of the patient's spine. That rod becomes a template rod which is then utilized for the configuring of another rod which is to be implanted into the patient and secured to aprovide a a protected template rod and does so in an efficient and reasonably cost-effective manner.
Still further, the assembled rod and sleeve of this invention present incremental length indicia affixed along the length of the rod so the surgeon can determine the overall length, as well as the location, for the bends of the template rod. With that information, the surgeon can then use the template to select a final rod and to bend the final rod to conform to the length and configuration of the template rod and then implant the final rod into the patient.
In accomplishing all of the foregoing, the present invention provides the coextensive length of an assembled rod and sleeve with two end plugs which extend within the respective opposite ends of the


error:

Error 500: Internal Server Error
URI
      /vs3/campanhas/editar/8 Class
      groovy.lang.MissingPropertyException Message
      No such property: oldImgPath for class: vs3.CampanhasController`
  Around line 119 of
  grails-app\controllers\vs3\CampanhasController.groovy

Line 119, in this case is def oldImg = new File(oldImgPath)
I've printed oldImgPath and the result was:

C:\Grails_IDE\workspace\vs3\web-app\images\banners\fc712691a63824948c11a19569682803.jpg

...and this file exists, I can load it by my browsers normally.
UP!
I changed this line:
def oldImgPath = servletContext.getRealPath("images/banners/${banner.image}")
to
def oldImgPath = servletContext.getRealPath("web-app/images/banners/${banner.image}")
...and I have the same error.
And, just in case, import org.codehaus.groovy.grails.web.context.ServletContextHolder was already included.
Before that, what else should I check?

A:

you defined the def oldImgPath in the scope of the 1st if-block, so it's invisible anywhere outside of it

been receiving subsidized rates, the act will result in a quick jump in rates. In June, the House voted to delay implementation of changes to grandfathered rates for three years instead of one, and for a one-year delay in the implementation of the rate changes that FEMA is rolling out.

(Copyright 2013 Gannett Co. Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


of 341, 849, 1625, and 2671 base pairs indicate that unwinding occurs at the same high ratios of helicase II protein/nucleotide, independent of DNA length (50% unwinding requires approximately 0.6 helicase II monomers/nucleotide in 2.5 mM MgCl2, 10% glycerol, pH 7.5, 37 degrees C). Helicase II protein is also able to unwind completely a nicked circular DNA molecule containing 2671 base pairs. At lower but still high molar ratios of helicase II protein to DNA, duplex DNA molecules containing a single-stranded (ss) region attached to a 3' end of the duplex are preferentially unwound in agreement with the results obtained by S. W. Matson [1986) J. Biol. Chem. 261, 10169-10175). This preferential unwinding of duplex DNA with an attached 3' ssDNA most likely reflects the availability of auv->refcount = 1;
    uv->v = &uv->u.value;  /* make it closed */
    setnilvalue(uv->v);
    cl->upvals[i] = uv;
  }
}

UpVal *luaF_findupval (lua_State *L, StkId level) {
  UpVal **pp = &L->openupval;
  UpVal *p;
  UpVal *uv;
  lua_assert(isintwups(L) || L->openupval == NULL);
  while (*pp != NULL && (p = *pp)->v >= level) {
    lua_assert(upisopen(p));
    if (p->v == level)  /* found a corresponding upvalue? */
      return p;  /* return it */
    pp = &p->u.open.next;
  }
  /* not found: create a new upvalue */
  uv = luaM_new(L, UpVal);
  uv->refcount = 0;
  uv->u.open.next = *pp;  /* link it to list


equal benefits for the women working on the staff of the university, going so far as trying to turn the academic staff association of the university into a union, in order to negotiate for benefits. The courts denied this bid, but many of her demands for equal benefits were later met.[23] In addition to her work at the University of Nairobi, Maathai became involved in a number of civic organizations in the early 1970s. She was a member of the Nairobi branch of the Kenya Red Cross Society, becoming its director in 1973. She was a member of the Kenya Association of University Women. Following the establishment of the Environment Liaison Centre in 1974, Maathai was asked to be a member of the local board, eventually becoming boardseparated in 1977. After a lengthy separation, Mwangi filed for divorce in 1979. Mwangi was said to have believed Wangari was "too strong-minded for a woman" and that he was "unable to control her". In addition to naming her as "cruel" in court filings, he publicly accused her of adultery with another Member of Parliament,[30] which in turn was thought to cause his high blood pressure and the judge ruled in Mwangi's favor. Shortly after the trial, in an interview with Viva magazine, Maathai referred to the judge as either incompetent or corrupt.[30] The interview later led the judge to charge Maathai with contempt of court. She was found guilty and sentenced to six months in jail. After three days in Lang'ata Women's Prison in Nairobi, her lawyer


would have arrived in Nyeri too late. My case, like many others, demonstrated a miscarriage of justice that was frequent at that time in Kenya and that led me, later, to be involved in the pro-democracy movement. Once again, I had lost in court. I would not be able to run.

Wangarĩ Muta Maathai – Unbowed, pp. 161.

In 1982, the Parliamentary seat representing her home region of Nyeri was open, and Maathai decided to campaign for the seat. As required by law, she resigned her position with the University of Nairobi to campaign for office. The courts decided that she was ineligible to run for office because she had not re-registered to vote in the last presidential election in 1979. Maathai believed this to be false and illegal, andof hunger strike, on 3 March 1992, the police forcibly removed the protesters. Maathai and three others were knocked unconscious by police and hospitalized.[45]PresidentDaniel arap Moi called her "a mad woman" and "a threat to the order and security of the country".[46] The attack drew international criticism. The US State Department said it was "deeply concerned" by the violence and by the forcible removal of the hunger strikers.[47] When the prisoners were not released, the protesters – mostly mothers of those in prison – moved their protest to All Saints Cathedral, the seat of the Anglican Archbishop in Kenya, across from Uhuru Park. The protest there continued, with Maathai contributing frequently, until early 1993, when the prisoners were finally released.[48]

During this time, Maathai was recognized with various awards


internationally, but the Kenyan government did not appreciate her work. In 1991 she received the Goldman Environmental Prize in San Francisco and the Hunger Project's Africa Prize for Leadership in London. CNN aired a three-minute segment about the Goldman prize, but when it aired in Kenya, that segment was cut out. In June 1992, during the long protest at Uhuru Park, both Maathai and President arap Moi travelled to Rio de Janeiro for the UN Conference on Environment and Development (Earth Summit). The Kenyan government accused Maathai of inciting women and encouraging them to strip at Freedom Corner, urging that she not be allowed to speak at the summit. Despite this, Maathai was chosen to be a chief spokesperson at the summit.[49]

During the first multi-party election of Kenya,Norwegian ambassador had called. "I am being informed that I have won the Nobel Peace Prize," I announced to myself and those around me in the car with a smile as I pulled the cell phone away from my ear and reconnected with my fellow passengers. They knew it was not a joke because happiness was written all over my face. But at the same time, tears steamed from my eyes and onto my cheeks as I turned to them. They, too, were now smiling broadly, some cheering and hugging me as if to both comfort and congratulate me, letting my tears fall on their shoulders and hiding my face from some of my staff, whom they felt shouldn't see me cry. But these were tears of great


2011 of complications arising from ovarian cancer while receiving treatment at a Nairobi hospital.[72]

In 2012, the Collaborative Partnership on Forests CPF, an international consortium of 14 organizations, secretariats and institutions working on international forest issues, launched the inaugural Wangarĩ Maathai Forest Champion Award. The 2012 inaugural winner of the Award was Narayan Kaji Shrestha.[73]

The 2017 award was presented at the 4th Global Landscapes Forum (GLF) in Bonn, Germany, 19–20 December 2017 to Maria Margarida Ribeiro da Silva. Maria Margarida Ribeiro da Silva, a Brazilian forestry activist, was awarded the Wangarĩ Maathai Forest Champion Award for her achievements in promoting community forest management and improving the quality of life for many Amazonian communities. In addition to being awarded the 2017 Wangarĩ Maathai Forest Champion Award, Ribiero da Silva alsoinformation, development of conflict-resolution strategies and improved regional conservation. Many of the resources are especially vulnerable because they are influenced by human impacts across many countries. As a result of this, many attempts are made by countries to develop agreements that are signed by multiple governments to prevent damage or manage the impacts of human activity on natural resources. This can include agreements that impact factors such as climate, oceans, rivers and these agreements have a long history with some multinational agreements being in place from as early as 1910 in Europe, America and Africa. Some of the most well-known international agreements include the Kyoto Protocol, discussion concerning environmental protection often focuses on the role of government, legislation, and law enforcement. However, in its broadest sense, environmental protection


are some exceptions, for example, in the Nigerian Aka culture women may hunt, even on their own, and often control distribution of resources. Ancient Egypt had female rulers, such as Cleopatra, Women throughout historical and ancient China were considered inferior and had subordinate legal status based on the Confucian law. In Imperial China, the Three Obediences promoted daughters to obey their fathers, wives to obey their husbands, Women could not inherit businesses or wealth and men had to adopt a son for such financial purposes. Late imperial law also featured seven different types of divorces, the status of women in China was also low largely due to the custom of foot binding. About 45% of Chinese women had bound feet in the 19th century, for the upper classes,to produce a seemingly harsh result. Nonetheless, the court remarked that such harsh results in individual cases may be the inevitable corollary of the "court's obligation in all cases to follow precedent and to implement controlling statutes and procedural rules." The court concluded that whatever hardships these combined provisions work on Title VII plaintiffs can be alleviated only by Congress and the drafters of the Federal Rules of Civil Procedure. Therefore, under Cooper, the limitations period is jurisdictional and not subject to equitable tolling.
Even if the limitations period was not jurisdictional, but was a statute of limitations and was subject to equitable tolling, the court would decline to toll the statute under the facts of this case. Plaintiff filed his complaint on September 5, 1985 and attached thereto


the facts underlying his claim. The decision of the EEOC did not apprise the court of the facts underlying plaintiff's claim. It was, therefore, necessary to have plaintiff come into court for status call prior to ruling on his motion for appointment of counsel. By the time the first status was set the thirty days limitation had passed. The equities do not favor plaintiff where his efforts to aid the court were minimal.
Plaintiff's third contention, that no prejudice would result to the government if the amendment was allowed, was considered and rejected by the Seventh Circuit in Stewart, supra. The court held that application of Rule 15(c) to the government in the absence of proper notice within the limitations period would result in prejudice by eliminating the statutekeeps everything simple. In a best-of-three match, the hunters and monster are dropped in a small, pre-determined dome with only one goal; take down your opponent(s). The monster starts at stage two with 50 percent armour, reducing the need to devour local wildlife, and when a hunter dies they're out until the next round. It's a bare-bones take on the Evolve formula, stripping away some of what makes the game unique. Still, if you're interested in shorter rounds where you can easily hone your combat skills, Arena Mode could be a welcome change on planet Shear.

Remember Superhot? It let you dodge bullets by controlling time à laThe Matrix, but a new VR game takes that premise even farther by making you the bullet. Drift is a game for


company announced today that it's spent £20 million to acquire Multiplay, a community-driven games company that focuses on live events, gaming services and eSports.

Like it or not, selfies in games are officially a "thing" -- and they're now invading classic titles like Doom. Linguica's new InstaDoom mod lets you spin the virtual camera around to take a shot of your Doom (or Doom II) marine, complete with Instagram-like filters and the seemingly inescapable selfie stick. Yes, you can now show your friends that you've killed a Spiderdemon by striking an obnoxious pose over its body. Is this a novelty? You bet. Still, it's fun to see a decades-old shooter make a commentary on the modern obsession with narcissistic photos.

In early 2012, Retailer GAME seemed destined to join Woolworths$4.6$days is almost buried in the noise, and from the PS it seems that the modulation at $\sim20.4$days is more evident. Nevertheless, thanks to its period-selection process, BEER found the correct orbital period in this case as well (as we show in Sect. \[sec5\]).

After the score assignment and the best-period selection, we visually inspected the $200$ highest score candidates of each field and assigned priorities of $1$–$3$ to targets that we deemed viable binary candidates, with priority $1$ assigned to the best candidates. These priorities were assigned through visual inspection of the photometric power spectrum, the goodness-of-fit of the BEER model, the correlation structure of the time-domain residuals, and other target specific features. Naturally, the visual inspection method and the resulting target priorities are subjective and prone to


: Template parameters of the composite-spectrum candidates$^a$.

\
$^{(a)}$This table is available in its entirety in machine-readable form at ftp://wise-ftp.tau.ac.il/pub/corotAAO. A portion of the table is shown here for guidance regarding its form and content. \[t3b\]

Table \[t3b\] lists the template parameters and $\alpha$ values used for the composite-spectrum BEER candidates. We only use the nomenclature ’A’ and ’B’ (both here and later in Table \[t3h\]) to denote the more and less luminous components, respectively. The measured RVs and errors of both components are given in machine-readable form at ftp://wise-ftp.tau.ac.il/pub/corotAAO.

Orbital solutions {#sec5}
=================

Confirming BEER binaries with non-composite spectra
---------------------------------------------------

To separate true BEER binaries from false detections (which we call false alarms for simplicity, or FAs), and to derive the orbital parameters of the true BEER SB1s, we fitted the derived RVs of non-compositeobserved, taking into account their BEER priorities, and then for the total number of CoRoT long-run light curves ($\sim110,000$), assuming that short-period binaries do not have a preference for center or anticenter fields. Doing so, we estimate that observing all $481$ selected candidates would have brought the number of confirmed binaries to $\sim110$, and that the expected number of beaming binaries that can be detected in CoRoT long-run light curves is $\sim300$. This confirms the prediction made by @zma2007: CoRoT and *Kepler* will be capable of detecting hundreds of non-eclipsing beaming binaries.

Investigating BEER’s false-alarm probability and nature in CoRoT long-run light curves, we showed that red giants introduce a major source of false candidates and demonstrated a way to improve BEER’s performance in extracting higher fidelity samples from