was FVR’s. life was really easier. my father’s business boomed, and brownouts seemed a thing of the past. all the ominous signals we’re seeing now (power, water shortages) are unmistakable signs of how much this admin has mismanaged our country. my father has now closed shop, and went back to being an employee after being his own boss for years. he’s already past retiring age yet he cnt even do that since our social security system makes people insecure. he’s been paying the highest premium over the years but now he cnt even expect he’ll receive the right pensions or how regular it might be. one of my siblings was refused the proper discounts when she was hospitalized bec they say my father has stopped paying his premiums.the Northwest Join us at N...http://seattle.carpediem.cd/events5557095-speakeasy-at-nightjar-a-weekly-electro-swing-party-at-nightjar/Speakeasy at Nightjar, A Weekly Electro Swing Party407 2nd AVE EXT SOUTH, Seattle, Washington 98104Nightjar

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place in the Top Five.

1.USC 2.Tennessee 3.Purdue 4.UCLA 5.Oklahoma

November 25 In the final week of games before the final polls, #1 USC had completed its season at 9–1, qualified for the Rose Bowl, and was in no danger of losing again.  #2 Tennessee won at Kentucky 17–7. Indiana had fallen out of the Top Ten, but made their way back in when they beat #3 Purdue at home in Bloomington.  There was a three-way tie in Big Ten Conference play.  Not only were Indiana, Purdue, and Minnesota each 6–1, Indiana beat Purdue, Purdue beat Minnesota, and Minnesota beat Indiana.  The Hoosiers had the better overall record (9–1 vs. 8–2 and 8–2), and since Purdue and Minnesota had been to the Rose Bowlme a mixtape when I was either 15 or 16 with "Bombshell". We had a band called Buncha Losers in high school. He was the drummer.

I love that song. One of the raddest things about that song is they set an alarm off like maybe halfway through. Or maybe it's kind of near the end, when they break down and everyone's just hitting their instruments. This alarm is just going all the way through the song. It's rad and abrasive.

That was my introduction to punk rock, and it was the classic story of one mixtape changing my life. Minor Threat was on there, Subhumans, probably stuff by Dinosaur Jr. and Sonic Youth. I was living in San Jose, and Green Day were putting out their first records. Operation


what they read or who do not read their emails.  Too
late for this one.  I will get Steve to give me a short description.

Mary

	From:  Sherri Sera                           03/07/2001 09:43 AM

To: Rosalee Fleming/Corp/Enron@ENRON, Mary Clark/Corp/Enron@ENRON
cc:

Subject: RE: Corporate Policy Committee

It's not like we've sent out a lot of memos about the corporate policy
committee, but this guy hasn't read the ones that did go out!  SRS
---------------------- Forwarded by Sherri Sera/Corp/Enron on 03/07/2001
09:43 AM ---------------------------

Anonymous

From: Anonymous on 03/07/2001 02:43 AM
To:
cc:

Subject: RE: Corporate Policy Committee

 Dear Office of the Chairman,
Could I begyour indulgence for just a few minutes please?  I,m guessing this
is good news for Dave and John.  But, what does the Corporate Policy
Committee do?  Aside from the board, are their many other executive level
committees?
I suppose that as a Senior Director, and +5year employee, that I should know,
however I can,t recall hearing about these groups before.
Regards,
Richard.

-----Original Message-----
From: Ken Lay and Jeff Skilling/Corp/Enron@ENRON
[mailto:IMCEANOTES-Ken+20Lay+20and+20Jeff+20Skilling_Corp_Enron+40ENRON@ENRON.
com] On Behalf Of Ken Lay & Jeff Skilling@ENRON
Sent: 06 March 2001 23:46
To: All Enron Worldwide@ENRON
Subject: Organizational Announcement

We are pleased to announce that Dave Delainey and John Sherriff are joining
the Enron Corporate Policy Committee.
With these additions, below is a current listing of Corporate Policy
Committee members.

Cliff Baxter
Rick Causey
Dave Delainey
Jim Derrick
Andy Fastow
Mark Frevert
Kevin Hannon
Stan Horton
Steve Kean
Ken Lay
Lou Pai
Ken Rice
John


Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons.
Decreases in GSH pools detected during ischemia sensitize neurons to excitotoxic damage. Thermodynamic analysis predicts that partial GSH depletion will cause an oxidative shift in the thiol redox potential. To investigate the acute bioenergetic consequences, neurons were exposed to monochlorobimane (mBCl), which depletes GSH by forming a fluorescent conjugate. Neurons transfected with redox-sensitive green fluorescent protein showed a positive shift in thiol redox potential synchronous with the formation of the conjugate. Mitochondria within neurons treated with mBCl for 1 h failed to hyperpolarize upon addition of oligomycin to inhibit their ATP synthesis. A decreased ATP turnover was confirmed by monitoring neuronal oxygen consumption in parallel with mitochondrial membrane potential (Deltapsi(m)) and GSH-mBCl formation. mBCl progressively decreased cell respiration,411 U.S. 1, 35-36, 93 S.Ct. 1278, 1297-1298, 36 L.Ed.2d 16 (1973). This right exists only by virtue of state law and must be enforced against state officials in state courts. Pennhurst State School and Hospital v. Halderman, supra, ___ U.S. at ___, 104 S.Ct. at 919.
There remains plaintiff's cause of action under the Fourteenth Amendment. The Commonwealth of Pennsylvania and its Department of Education are not amenable to suit in this court under the Fourteenth Amendment. Fitts v. McGhee, 172 U.S. 516, 19 S.Ct. 269, 43 L.Ed. 535 (1899). The Eleventh Amendment bars action against the State without its consent, regardless of whether the action is for monetary or equitable relief. See Cory v. White, 457 U.S. 85, 91, 102 S.Ct. 2325, 2329, 72 L.Ed.2d 694 (1982).
It


pathway of hippocampal slices from R(AB) mutant mice. In contrast, LTP induced by temporally compressed tetraburst stimulation was normal in slices from R(AB) mutants, and its long-term maintenance was not significantly affected by bath application of KT-5720, an inhibitor of catalytic subunits of PKA. In slices from wildtype mice, LTP induced by spaced tetraburst stimulation was significantly attenuated by KT-5720. These genetic and pharmacological experiments show that LTP induced by these compressed patterns of stimulation does not require PKA activation. Thus, altering the temporal spacing of synaptic stimulation per se critically modulates the PKA-dependence of hippocampal LTP. PKA-dependent LTP is selectively recruited by temporally spaced, multiburst synaptic stimulation.a communication device, etc. The state of the system at time $k \in \mathbb{N}$ is the vector $X^N_k = (X^N_{k,1}, \ldots X^N_{k,n}) \in \Delta$ where $N X^N_{k,i}$ equals the number of agents having strategy $i.$ The system evolves as follows. Assume that at time $k$ the system is in state $X^N_k = x.$ Then an agent is randomly chosen in the population. If the chosen agent is an $i-$strategist, he/she switches to strategy $j$ with probability $K_{ij}(x).$ This makes $(X^N_k)_{k \geq 1}$ a discrete time Markov chain, which transition probabilities are $$\Pr(X^N_{k+1} = x + \frac{1}{N}(e_j-e_i) | X^N_k = x) = x_i K_{ij}(x)$$ where $(e_1, \ldots, e_n)$ is the standard basis of $\RR^n.$ Let \[odepop\] L(x) = - Id + K(x). By standard mean-field approximation (see [@Kurtz70], [@BW03]


subject). Using tools from stochastic approximation theory, it can be shown (see [@B97]) that, under certain irreducibility assumptions, the long term behavior of $(\mu_k)$ can be precisely related (see [@B97], [@B99], [@BH96] and the brief discussion preceding corollary \[chaintrans\]) to the long term behavior of the differential equation on $\Delta$ \[odereinf\] = -x + (x) where $\pi(x) \in \Delta$ is the invariant probability of $K(x).$ Note that (\[odereinf\]) can be rewritten as (\[ode\]) with $L_{ij}(x) = \delta_{ij} - \pi_j(x).$

Hypotheses, Notation, and Preliminaries {#sec:prelim}
=======================================

Let $L$ be a rate matrix, as defined in the introduction. Then $L$ is the infinitesimal generator of a continuous time Markov chains on $S.$ A probability $\pi \in \Delta$ is called [*invariant*]{} for $L$ if it is invariant for the associated Markov chain, or equivalently\[main\] and Hypothesis \[hyp2\] or; Assumptions of Proposition \[main2\]. Then every omega limit set of $\Phi$ is a connected subset of $\mathbf{Eq}(F).$ A set $L$ is called [*attractor free*]{} or [*internally chain transitive*]{} provided it is compact, invariant and $\Phi|L$ has no proper attractor. For reinforced random processes like the ones defined in section \[sec:reinforc\], limit sets of $(\mu_n)$ are, under suitable assumptions, attractor free sets of the associated mean field equation (\[odereinf\]) (see [@B97]). More generally attractor free sets are limit sets of [*asymptotic pseudo trajectories*]{} (see [@BH96]). It is then useful to characterize such sets. Note however that the existence of a strict Lyapounov function, doesn’t ensure in general, that internally chain transitive sets consist of equilibria (see e.g  Remark 6.3 in [@B99]). \[chaintrans\] Assume that


that  $L(x)$ is reversible with respect to $\pi,$ independent on $x.$ Then $x \mapsto \frac{x}{\pi}$ is the gradient of the $\chi^2$ function $V(x) = \sum_i (\frac{x_i}{\pi_i} - 1)^2 \pi_i.$ Hence $F(x) = - grad_g V(x)$  for some metric $g$.}
\eex

Under the weaker assumption that $x s()$ is a quasi-gradient for some strictly increasing function $s$ (see Theorem \ref{main})) it is no longer true that $F$ is a gradient, but it can be approximated by a gradient.  The next Lemma is the key tool. Its proof is identical to the proof of Proposition \ref{reversequil}.
\blem
\label{reversequil2}
Assume that assumptions of Theorem \ref{main} hold and that
 for all $x , L(x)$ is reversible with respect to $(x).$ Then there exists a  metric $g\_0$ on $$ such that for $p (F)adaptation of the proof of Theorem 2.10 in [@BR05]. This later theorem required the use of an infinite dimensional version of Sard’s theorem for Fredholm maps. Here things are much easier since the state space has finite dimension. By Proposition \[reversequil\], it suffices to find ${\cal G} \subset M_{n}^s(\RR)$ such that for all $U \in {\cal G}$ the Lyapounov function $$V_U :\Delta \mapsto \RR,$$ $$x \mapsto \sum_i x_i \log(x_i) + \sum_i U^0_i x_i + 2 \beta \sum_{ij} U_{ij}x_i x_j$$ has non degenerate critical points. Openness is not an issue. For density, note that if one set $\tilde{U}_{ij} = U_{ij} - \frac{1}{\beta}(\eps_i + \eps_j)$ with $\eps \in T\Delta.$ Then for all $h \in T\Delta$ $\langle \nabla V_{\tilde{U}}(x), h \rangle = \langle \nabla V_U(x) -  \eps, h \rangle.$ By


Q:

How to group results after a selection in Laravel

I have a controller that returns me expiration_date and status of a ticket, referring an user_id.
After I get all tickets that an user has registered, the controller will show when expire and the status. Something like this:
0
expiration_date "2018-03-03 20:38:32"
status  "expired"

1
expiration_date "2018-03-03 20:38:32"
status  "expired"

2
expiration_date "2018-03-03 20:38:32"
status  "expired"

3
expiration_date "2018-05-03 09:02:06"
status  "expired"

4
expiration_date "2019-05-03 09:02:06"
status  "available"

5
expiration_date "2019-05-03 10:00:20"
status  "available"

My problem here is that I need to group the data that has the same expiration_date and status. So, I would group the data 0, 1, 2 and the data 4 and 5 in an unique item, counting the number of items. Something like this:
Count: 3
expiration_date "2018-03-03 20:38:32"
statusDOWNLOADS

OTHERS

Smack Down Pain

Description

WWE SmackDown! Here Comes the Pain (Known as Exciting Pro Wrestling 5 in Japan) is a video game released on the PlayStation 2 console by THQ on October 27, 2003. It is a sequel to WWE SmackDown! Shut Your Mouth and is part of the WWE SmackDown! (later renamed WWE SmackDown vs. Raw, now simply WWE) series based on World Wrestling Entertainment's weekly TV show of the same name. It was the first SmackDown! game to feature a catchphrase not linked back to The Rock in its title. It was also the final WWE game under the SmackDown! name and it was succeeded by WWE SmackDown! vs. Raw.

WWE SmackDown! Here Comes the Pain (Known as Exciting Pro Wrestling 5 in Japan) is a video game released


on the PlayStation 2 console by THQ on October 27, 2003. It is a sequel to WWE SmackDown! Shut Your Mouth and is part of the WWE SmackDown! (later renamed WWE SmackDown vs. Raw, now simply WWE) series based on World Wrestling Entertainment's weekly TV show of the same name. It was the first SmackDown! game to feature a catchphrase not linked back to The Rock in its title. It was also the final WWE game under the SmackDown! name and it was succeeded by WWE SmackDown! vs. Raw.monastery in the mountains of Colorado, serving as their abbot. A hopelessly deadlocked College of Cardinals turned to Rivera as a stunning choice.

When Pope Francis moved out of the Vatican, announcing his plans to "live with the people of the church" in ten different locations of the world over his first two years, this symbolized his commitment to decentralize significant, unprecedented power and authority to regional and national conferences of bishops. His "spirituality of relinquishment" reshaped the understanding of the Bishop of Rome, a process first hinted at by Pope John Paul II at the end of the twentieth century, but not realized until Pope Francis.

This devolution of power on the part of Rome to regional and national bishops was essential in enabling Orthodox churches to make an


at a frequency equal to half the predetermined sampling frequency Fs; and sequentially selecting output signals from the shift registers at a frequency equal to twice the predetermined sampling frequency Fs to generate the digital quadrature-modulation-resultant signal.
A third aspect of this invention provides an apparatus for modulation based on orthogonal frequency division multiplexing. The apparatus comprises means for assigning data pieces representative of in-phase components and quadrature components of a digital-modulation-resultant signal to frequencies for inverse fast Fourier transform; means for executing the inverse fast Fourier transform at a predetermined sampling frequency Fs to convert the data pieces into a real-part signal and an imaginary-part signal; means for shifting phases of the real-part signal and the imaginary-part signal to convert the real-part signal and the imaginary-part signal intoa look at the Definition of hyperalgesia by the NCI dictionary of cancer terms:

An increased sensitivity to feeling pain and an extreme response to pain. Hyperalgesia may occur when there is damage to the nerves or chemical changes to the nerve pathways involved in sensing pain. This may be caused by tissue injury or inflammation or by taking certain drugs, such as opioids, for chronic pain. People with hyperalgesia tend to feel extreme pain even though an injury or medical condition has not gotten worse. This pain may get worse over time, and it may extend to other areas of the body. It may also become a new or different type of pain than the original pain.

Sounds much like what you apparently wish for,although not quite. Rather than


presence of complement components in the immune complexes results in a higher stimulation of ROS production. In this case, however, there is no inhibition by fluid-phase IgG. The effect of complement is strongly dependent on the presence of divalent cations (Ca2+ or Mg2+) in the medium, whereas the stimulation of ICIgG (without complement) does not depend on these cations. We have obtained some evidence indicating that iC3b should be the component involved in the effect of complement through interaction with the CR3 receptor. The absence of the inhibitory effect of fluid-phase IgG in ROS production when complement is present in the immune complex shows that complement may be important in vivo not only in the production of chemotactic factors for PMN, but also in the next phase ofgroup completed the planned regimens of chemotherapy and surgery. Patients of the NAC group had a response rate of 78.6% (95% confidence interval 57.1-100.0%). The most common adverse effect was leukocytopenia (42.9%). However, only four patients (28.6%) had upper Grade 2 leukocytopenia, and all recovered promptly. Postoperative complications were not significant differentiated between NAC and SA group of patients (7.2 vs. 4.0%). Patients in the NAC group had a significantly better survival than those in the SA group (P = 0.03). The median survival has not been reached after 26.9 months of median follow-up for patients in the NAC group. 1-, 2-, and 3-year survival rates were 92.3, 92.3, and 61.5%, respectively. NAC was identified as an independent prognostic factor in all patients (P = 0.018). Neoadjuvant chemotherapy


charset if it chooses to ignore your request header, so you should account for that).
Try something like this:
function GetInetFileAsString(const fileURL: string): string;
const
  C_BufferSize = 1024;
var
  sAppName: string;
  hSession, hURL: HInternet;
  Buffer: array of Byte;
  BufferLen: DWORD;
  strHeader: String;
  strPageContent: TStringStream;
begin
  Result := '';
  SetLength(Buffer, C_BufferSize);
  sAppName := ExtractFileName(Application.ExeName);
  hSession := InternetOpen(PChar(sAppName), INTERNET_OPEN_TYPE_PRECONFIG, nil, nil, 0);
  try
    strHeader := 'Accept-Charset: utf-8'#13#10;
    hURL := InternetOpenURL(hSession, PChar(fileURL), PChar(strHeader), Length(strHeader), 0, 0);
    try
      strPageContent := TStringStream.Create('', TEncoding.UTF8);
      try
        repeat
          if not InternetReadFile(hURL, PByte(Buffer), Length(Buffer), BufferLen)Q:

Generating function for reciprocals of Harmonic numbers?

Find an exponential or ordinary generating function of reciprocal Harmonic numbers.
$f(x)=\sum\limits_{n=1}^{\infty} \frac{1}{H_n}\frac{x^n}{n!}$ or
$f(x)=\sum\limits_{n=1}^{\infty} \frac{1}{H_n}x^n$
Also, it would be nice to see EGF or OGF for other reciprocals of common "numbers", like binomial coefficients, Stirling numbers, Catalan numbers, etc.
P.S. I suspect one could use Digamma function here

A:

This is not a complete answer, just too long for a comment.
Let us work with EGF $f(x)=\sum_{n=1}^{\infty} \frac{1}{H_n}\frac{x^n}{n!}$.
Clearly, $$H_n = \int_0^1 \frac{1-x^n}{1-x}dx.$$
Therefore,
$$
e^z -1 = \sum_{n=1}^\infty \frac{H_n z^n }{H_n n!} = \int_0^1 \sum_{n=1}^\infty \frac{ z^n (1-x^{n})}{H_n n!}\frac{dx}{1-x} = \\
= \int_0^1 \frac{f(z) - f(zx)}{1-x} dx = z\int_0^1 \int_{x}^1\frac{f'(zu)}{1-x}du\, dx = -z\int_0^1 f'(zu) \log(1-u) du =\\
= -\int_0^z f'(x) \log(1-x/z) dx.
$$
This gives some integral equation for $f'$.


use of LIBS in reduced pressure environment because of the increased need for high resolution spectra \[[@b30-sensors-10-04907]--[@b33-sensors-10-04907]\]. Besides the usual LIBS equipment, these pressure/atmospheric studies also require a chamber to control the atmospheric conditions, which include ablation chambers equipped with vacuum pumps and gauges for controlling the pressure as well as gas inlets and mixing manifolds for varying buffer gases ([Figure 1](#f1-sensors-10-04907){ref-type="fig"}) \[[@b34-sensors-10-04907]\].

While there have been several studies of LIBS under non-Earth ambient conditions, none of the studies currently available are comprehensive. Therefore, this review focuses on compiling an understanding of LIBS phenomena that have been gained through the various pressure dependence and atmospheric composition studies. The pressure studies have been divided into two regimes: \>760 Torr and \<760 Torr. The gas composition studies include comparisons of air,in work by Dreyer *et al*. \[[@b39-sensors-10-04907]\].

Using a Nd:YLF laser with a 10 ns pulse duration, Dreyer *et al*. performed LIBS at varying reduced pressures on a hematite sample \[[@b39-sensors-10-04907]\]. [Figure 3](#f3-sensors-10-04907){ref-type="fig"} shows several LIBS spectra at varying pressures, focusing primarily on Ca and Mg lines. It can be observed in [Figure 3](#f3-sensors-10-04907){ref-type="fig"} that as the surrounding pressure is decreased from 100 mbar to 10 mbar, a gradual increase in LIBS intensity is observed. Also, a maximum intensity occurs between 5 and 10 Torr, while pressures below 5 Torr resulted in a significant decrease in LIBS emission intensity. This significant decrease in emission intensity at very low pressures is also seen in work by Shu *et al*. comparing LIBS at lunar simulated condition of 5 × 10^−5^ Pa


regression was achieved at 7 Torr CO~2~.

In another study involving Mars atmosphere simulation, Brennetot *et al*. \[[@b19-sensors-10-04907]\] found that LIBS of basalt sample at 7 Torr CO~2~ resulted in an improvement when compared with atmospheric conditions. Brennetot *et al*. also studied the effect of LIBS at varying CO~2~ pressures; at very low pressures (\<3 Torr) the plasma plume was highly expanded and difficult to fully image on to fiber optic. At pressures between 3 and 15 Torr, the lifetime of Cu (515.324 nm) decreased gradually with increasing pressures. This reduction in lifetime with increasing pressure is likely do to the increase in collisions at higher pressures, resulting in more rapid cooling of the plasma. There was no mention of whether the increase in collisions at the higher pressuresa pressure of 100 Torr would likely not have the same adverse effects associated with other gases, such as N~2~ or Ar, which would breakdown more easily from the expanding plasma shock wave and shield the sample.

4.. Conclusions
===============

Not all of the reviewed studies corroborate well with each other, in fact. the cited work by Vadillo *et al*. \[[@b41-sensors-10-04907]\] seems to contradict results from many other experiments \[[@b15-sensors-10-04907],[@b19-sensors-10-04907],[@b39-sensors-10-04907],[@b45-sensors-10-04907],[@b49-sensors-10-04907]\] because of the difference in experimental conditions. Many variables can affect LIBS signal, for example, emission collection optics, irradiance, gating delay and width and sample surface conditions. Brennetot *et al*. \[[@b19-sensors-10-04907]\] noted that if a plasma plume gets too large, in low pressure atmospheres for example, light may not be completely collected if proper optical considerations are not made. Also, irradiance


for extreme environments and applications requiring high resolution and S/N.

Work supported by the U.S. Department of Energy through the INL Laboratory Directed Research & Development (LDRD) Program under DOE Idaho Operations Office Contract DE-AC07-05ID14517.

![Schematic of typical apparatus for a pressure and gas composition LIBS studies. Reprinted from reference \[[@b23-sensors-10-04907]\].](sensors-10-04907f1){#f1-sensors-10-04907}

![Comparison of LIBS spectra of Si at atmospheric and 10-6 Torr. Reprinted from reference \[[@b38-sensors-10-04907]\].](sensors-10-04907f2){#f2-sensors-10-04907}

![LIBS spectra of a geological sample (oolithic hematite) at various pressures. Reprinted from reference \[[@b39-sensors-10-04907]\].](sensors-10-04907f3){#f3-sensors-10-04907}

![LIBS spectra of Al at atmospheric conditions **(a--c)** and at 4 Torr **(d--f)** with increasing delay times (0, 85 and 200 ns). Reprinted from reference \[[@b45-sensors-10-04907]\].](sensors-10-04907f4){#f4-sensors-10-04907}

![Two-dimensional Cu plasma images at different pressures produced using an accumulation of ten 50 μJ laser pulses, 10 ns second delay and 500 ns gate width. ReprintedQ:

Problem when vertical & horizontal borders of table cells have different colors

Suppose I've a table where columns are separated from each other by the use of a left white border:
td, th {
  &:not(:first-child) {
    border-left: 10px solid #fff;
    font-family: monospace;
  }
}

It looks the following:

Looks pretty nice. And now I need to separate all rows from the summary row by the use of a dark line:
tbody {
  tr {
    &:last-child {
      background: #EAF0F6;
      border-top: 1px solid #000;
    }
  }
}

I get the following picture:

The separating border becomes dotted, how to fix that?
http://jsfiddle.net/m1a530td/40/

A:

You can use padding with a inner box-shadow instead of a border to


get the white space between columns and a border without gaps (demo):
td, th {
  &:not(:first-child) {
    padding-left: calc(10px + 1em);
    -webkit-box-shadow: inset 10px 0px 0px 0px rgba(255,255,255,1);
    -moz-box-shadow: inset 10px 0px 0px 0px rgba(255,255,255,1);
    box-shadow: inset 10px 0px 0px 0px rgba(255,255,255,1);
    font-family: monospace;
  }
}

court order covering the two newest ones.

The company released a profit forecast after the verdict on Tuesday saying it estimates net income of 133 billion yen ($1.2 billion) in the year through March 31, 2017.

The Kansai case was one of many going through the courts after the Japanese public turned away from nuclear power following the Fukushima meltdowns of 2011, the world’s worst nuclear calamity since Chernobyl in 1986.

Just three out of Japan’s 42 operable reactors are running and the pace of restarts has been protracted despite strong support from Prime Minister Shinzo Abe’s government, which is keen to restore a power source that provided about a third of electricity supply before the Fukushima disaster.

Residents have lodged injunctions against nuclear plants across Japan and lower courts have been


Film showing We the Uncivilised

Film showing We the Uncivilised
with the Oxford Permaculture Picturehouse
Booking is required because we forgot to book the lounge downstairs.
We will charge for entry, and make a donation to OARC.(event confirmed; keyholder is: Stig)(Rom) v Barbora Zahlavova Strycova (Cz, 32)

Sloane Stephens (US, 24) v Shuai Zhang (Chn)

Samantha Stosur (Aus) v qualifier

Qualifier v Lizette Cabrera (Aus)

Qualifier v Sofia Kenin (US, 14)

Johanna Konta (GB, 12) v Ons Jabeur (Tun)

Madison Brengle (US) v Caroline Garcia (Fr)

Kristie Ahn (US) v Caroline Wozniacki (Den)

Qualifier v Dayana Yastremska (Ukr, 23)

Qiang Wang (Chn, 27) v Pauline Parmentier (Fr)

Fiona Ferro (Fr) v Alison Van Uytvanck (Bel)

Tamara Zidansek (Svn) v Na-Lae Han (Kor)

Anastasia Potapova (Rus) v Serena Williams (US, 8)

Belinda Bencic (Swi, 6) v Anna Karolina Schmiedlova (Svk)

Qualifier v Jelena Ostapenko (Lat)

Sara Sorribes Tormo (Sp) v Veronika Kudermetova (Rus)

Astra Sharma (Aus) v Anett Kontaveit (Est, 28)

Donna Vekic (Cro, 19) v Maria Sharapova (Rus)

Alize Cornet (Fr) v qualifier

Iga Swiatek (Pol) v Timea Babos (Hun)

Carla Suarez Navarro (Sp) v Aryna Sabalenka (Blr,


(Ser)

Taylor Townsend (US) v Jessica Pegula (US)

Laura Siegemund (Ger) v Coco Vandeweghe (US)

Kristina Mladenovic (Fr) v Karolina Pliskova (Cz, 2)

On the other side of the draw, it looks as if it will be a race to the semi-finals between Simona Halep and the world No 2, Karolina Pliskova. It is Katie Boulter’s misfortune to be in Pliskova’s quarter – and the Briton is up against the world No 5, Elina Svitolina, in the first round.

On the men’s side, the draw, a magical mystery tour for fringe contenders, has hurled Dan Evans and Kyle Edmund into the same quarter as the seven-time champion Novak Djokovic and, beyond that if the wholly improbable were to happen, the same half as Roger Federer.

Federer, who has six Australian Opens among his 20may have missed some key assessment tools. At times, a single author determined the inclusion eligibility of the tools identified in our literature search strategy. However, consensus between at least two reviewers was required for an instrument to be included in this paper.

Assessment tools must be suitable for and validated in the population of interest. A majority of the tools that we found have been used in a physician population but have never been validated in this population. Many of the tools have been designed for and validated in special populations, and their applicability, reliability, and validity in a physician population is not clearly demonstrated in the medical literature. In the absence of independent validation, however, the results of these tools should be interpreted with caution.

Physician well-being is


and thicker to avoid loss of pad during etching, drilling and soldering.
Anything with mechanical attachment wants all the copper anchor you can reasonably give it.
Track between pins on ?pot? at lower left is OK but you could run track from pin 1 out and up and track to pin 2 around the end and have fatter pads and tracks.
Q1 2 3 stand vertical ?
OK if on heat sink with mechanical support for FETs.
If not heatsunk then 'lying down' gives MUCH longer life.
R4 5 6 slightly staggered ? - only cosmetic but proper alignment improves looks.
Gate drive R's help damp ringing. - a few Ohms usually.
IF switch speed is high you may need gate drivers -
OK if <= 1 kHz and MAYBE <= 10kHz.
Power supply can be < 12V - add a LARGE filter capacitor.
ENSURE it is not > 12V - some clone nanos do not like over 12V.
Lower reduces on-device regulator dissipation.
More can be said .


     return errorMessage;
            }
        public void setErrorMessage(String errorMessage) {
            this.errorMessage = errorMessage;
        }

        @Override
        public String toString() {

            return (this.errorCode + " " + this.errorMessage);
        }
}

A:

Each time the (uncaught) exception is thrown, SpringBoot returns Http-500 Internal Server Error. There are many ways of handling exceptions in Spring.
Let's say I have my controller and I implicitly throwCyanine dyes have been widely used for labeling biomolecules for a variety of applications such as DNA sequencing. See, for example, U.S. Pat. No. 5,571,388, incorporated herein by reference, for exemplary methods of identifying strands of DNA using cyanine dyes. Scientists favor using cyanine dyes in biological applications because, among other reasons, many of these dyes operate in the near IR (NIR) region of the spectrum (600-1000 nm). This makes these cyanine dyes less susceptible to interference from autofluorescence of biomolecules.
Other advantages of cyanine dyes Include: 1) cyanine dyes strongly absorb and fluoresce light; 2) many cyanine dyes do not rapidly bleach under the fluorescence microscope; 3) cyanine dye derivatives can be made that are simple and effective coupling reagents; 4) many structures and synthetic procedures are available


written permission. No license is granted to the trademarks of
// the copyright holders even if such marks are included in this software.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
// AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
// IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
// ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE
// FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
// DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
// SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
// CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
// OR TORT (INCLUDING NEGLIGENCE ORto the nearest integer?
591
What is 15627233 to the power of 1/2, to the nearest integer?
3953
What is 3154245 to the power of 1/2, to the nearest integer?
1776
What is the square root of 5401461 to the nearest integer?
2324
What is the third root of 15331485 to the nearest integer?
248
What is the square root of 989397 to the nearest integer?
995
What is the square root of 18761342 to the nearest integer?
4331
What is the third root of 4175137 to the nearest integer?
161
What is the third root of 67391 to the nearest integer?
41
What is the fifth root of 1239124 to the nearest integer?
17
What is 12741977 to the power of 1/3, to the nearest integer?
234
What is the eighth root of 7502375 to the nearest integer?
7
What is 148460 to the power of 1/3, to the nearest integer?
53
What


to the power of 1/4, to the nearest integer?
14
What is the square root of 18086309 to the nearest integer?
4253
What is 278843 to the power of 1/9, to the nearest integer?
4
What is 3796850 to the power of 1/3, to the nearest integer?
156
What is 271926 to the power of 1/10, to the nearest integer?
3
What is the third root of 98563 to the nearest integer?
46
What is the seventh root of 3389453 to the nearest integer?
9
What is the third root of 665880 to the nearest integer?
87
What is the cube root of 12822523 to the nearest integer?
2Breakers 1/8

Overlooking Pippi Beach, this fully self contained unit will be perfect for any stay in Yamba! The Breakers Complex is situated opposite Pippi Beach, one of Yamba's most famous and favourite beaches, which stretches all the way down to Angourie. The Breakers boasts a very relaxed lifestyle in this resort style complex, which features a pool, heated spa and BBQ area - the perfect place to take advantage of on those hot and sunny days in Yamba! All linen is included for your stay at The Breakers; it couldn't be any easier for a memorable holiday in Yamba, allowing you to enjoy all the spoils that Yamba has to offer!

This 3 bedroom, 2 bathroom unit is situated on the second floor and has magnificent views of Pippi


   (input) INTEGER
*          The leading dimension of the array A. LDAB >= KL+KU+1.
*
*  D       (output) REAL array, dimension (min(M,N))
*          The diagonal elements of the bidiagonal matrix B.
*
*  E       (output) REAL array, dimension (min(M,N)-1)
*          The superdiagonal elements of the bidiagonal matrix B.
*
*  Q       (output) REAL array, dimension (LDQ,M)
*          If VECT = 'Q' or 'B', the m-by-m orthogonal matrix Q.
*          If VECT      END IF
*
               DO 40 J = J1, J2, KB1
*
*                 create nonzero element a(j-1,j+ku) above the band
*                 and store it in WORK(n+1:2*n)
*
                  WORK( J+KUN ) = WORK( J )*AB( 1, J+KUN )
                  AB( 1, J+KUN ) = WORK( MN+J )*AB( 1, J+KUN )


  40          CONTINUE
*
*              generate plane rotations to annihilate nonzero elements
*              which have been generated above the band
*
               IF( NR.GT.0 )
     $            CALL SLARGV( NR, AB( 1, J1+KUN-1 ), INCA,
     $                         WORK( J1+KUN ), KB1, WORK(  ML = ML - 1
               ELSE
                  MU = MU - 1
               END IF
   80       CONTINUE
   90    CONTINUE
      END IF
*
      IF( KU.EQ.0 .AND. KL.GT.0 ) THEN
*
*        A has been reduced to lower bidiagonal form
*
*        Transform lower bidiagonal form to upper bidiagonal by applying
*


              E( I-1 ) = RC*AB( KU, I )
               END IF
               IF( WANTPT )
     $            CALL SROT( N, PT( I, 1 ), LDPT, PT( M+1, 1 ), LDPT,
     $                       RC, RS )
  110       CONTINUE
       END IF
      ELSE
*
*        A is diagonal. Set elements of E to zero and copy diagonal
*        elements to D.
*
         DO 140 I = 1, MINMN - 1
            E( I ) = ZERO
  140    CONTINUE
         DO 150 I = 1, MINMN
            D( I ) = AB( 1, I )
  150    CONTINUE
      END IF


commitment. We consider finite SGs, in which the leader and the follower have $m$ and $n$ [*pure strategies*]{} at their disposal, respectively, and their utilities for all possible outcomes are given by the matrices $u^L,u^F \in \mathbb{R}^{m \times n}$. The entries $u^L (i,j)$ and $u^F(i,j)$ denote the utilities of the leader and the follower, under [*pure strategy profile*]{} $(i,j) \in [m] \times [n]$. We use ${\mathcal{G}}= (u^L,u^F)$ to denote the SG with payoff matrices $u^L$ and $u^F$; we omit $m$ and $n$ as they are clear from context.

Like one-shot games, the agents are allowed to employ mixed strategies whereby they randomize over actions in their strategy set. A mixed strategy of the leader is a probability distribution over $[m]$, denoted by ${\mathbf{x}}\in \Delta^{m-1} = \{{\mathbf{x}}\geq 0 : \sum_{iaccess to ${\textit{{BR}}}$), or observe follower payoffs at pure strategy profiles during play (akin to having query access to $u^F$ as a function). Hence, this can be cast as the problem of learning an SSE with a specified notion of query access to information about the follower’s incentives.

Consider an SG ${\mathcal{G}}= (u^L,u^F)$. If the follower controls the flow of information to the leader in this paradigm, he may consider perpetually interacting with the leader as if he had a different payoff matrix ${\tilde{u}^F}$, which can make the leader believe that both agents are playing the game $\widetilde{{\mathcal{G}}}=(u^L,{\tilde{u}^F})$. This deceiving power provides the follower with an incentive to act according to $\widetilde{{\mathcal{G}}}$ for a judicious choice of ${\tilde{u}^F}$, because the SSEs in $\widetilde{{\mathcal{G}}}$ may provide larger utility (according to


(iv), $$\begin{aligned}
\min_{\ell' \in \widehat{S}} u^L({\mathbf{y}},\ell') \le u^L({\mathbf{x}}, j),\end{aligned}$$ then by we will have $u^L({\mathbf{y}}, \ell) \le u^L({\mathbf{x}}, j)$ for every $\ell \in {\widetilde{{\textit{{BR}}}}}({\mathbf{y}}) \cap \widehat{S}$. This, together with (ii) and (iii), will imply that $u^L({\mathbf{x}}, j) \ge u^L({\mathbf{y}}, \ell)$ for every $\ell \in {\widetilde{{\textit{{BR}}}}}({\mathbf{y}})$. Therefore, $({\mathbf{x}}, j)$ will indeed form an SSE given that $j \in {\widetilde{{\textit{{BR}}}}}({\mathbf{x}})$ by (i). We state this observation as the following lemma.

\[lmm:key-condition\] If $\min_{\ell' \in \widehat{S}} u^L({\mathbf{y}},\ell') \le u^L({\mathbf{x}}, j)$ holds for all ${\mathbf{y}}\in\Delta^{m-1}$ such that ${\widetilde{{\textit{{BR}}}}}({\mathbf{y}}) \cap \widehat{S} \neq {\varnothing}$, then the payoff matrix defined by induces $({\mathbf{x}}, j)$.

The proof of Theorem \[thm:payoff-inducibility-M\] is then completed by showing the following result.

\[prp:key-condition-holds\] If $u^L({\mathbf{x}},j) \geq M$ and $U_j(x) \neq {\varnothing}$, then we can construct $\widehat{S} \subseteq [n] \setminus \{j\}$ and $\alpha > 0$ in\sum_{i=1}^{m-1} y_i \leq 1\right\}.$$ Accordingly, we can write the utility function as $$\begin{aligned}
u^L({\mathbf{y}},\ell)
= {\mathbf{g}}_\ell \cdot {\mathbf{y}}+ u^L(m, \ell),\end{aligned}$$ where ${\mathbf{g}}_\ell \in \mathbb{R}^{m-1}$ and its $i$-th component is $g_{\ell, i} = u^L(i, \ell) - u^L(m, \ell)$; “$\cdot$” denotes the inner product. Hence, we have $$\begin{aligned}
\label{eq:rewrite-ul}
u^L({\mathbf{y}},\ell) = {\mathbf{g}}_\ell \cdot ({\mathbf{y}}-{\mathbf{y}}^*) + u^L({\mathbf{y}}^*,\ell) =
\begin{cases}
{\mathbf{g}}_\ell \cdot ({\mathbf{y}}-{\mathbf{y}}^*) + V & \text{if } \ell \in S \\
{\mathbf{g}}_j \cdot ({\mathbf{y}}-{\mathbf{y}}^*) + u^L({\mathbf{x}},j) & \text{if } \ell = j
\end{cases}\end{aligned}$$ where $u^L({\mathbf{y}}^*,\ell) = V$ for all $\ell \in S$ by the definition of $S$, and $u^L({\mathbf{y}}^*,j) = u^L({\mathbf{x}},j)$ by Lemma \[lmm:key-claim-yystar\]. Note that since $U_j({\mathbf{x}}) \neq {\varnothing}$, it must be that ${\mathbf{g}}_j \neq 0$.

We also write the $m$ boundary conditions that define $\Delta^{m-1}$ as ${\mathbf{e}}_i \cdot {\mathbf{y}}\ge \beta_i$. Namely, for each $i \in [m-1]$, let ${\mathbf{e}}_i \in


S$, ${\mathbf{e}}_i \cdot {\mathbf{z}}\geq 0$ for all $i \in B$, and ${\mathbf{g}}_j \cdot {\mathbf{z}}> 0$.

Then, by picking $\delta > 0$ sufficiently small, it holds for ${\mathbf{y}}= {\mathbf{y}}^* + \delta {\mathbf{z}}$ that:

-   By , we have the following for all $\ell \in S$: $$u^L({\mathbf{y}},\ell) = {\mathbf{g}}_\ell \cdot ({\mathbf{y}}- {\mathbf{y}}^*) + V = \delta {\mathbf{g}}_\ell \cdot {\mathbf{z}}+ V \geq V.$$ In addition, $$u^L({\mathbf{y}},j) = {\mathbf{g}}_j \cdot ({\mathbf{y}}-{\mathbf{y}}^*) + u^L({\mathbf{y}}^*,j) = \delta {\mathbf{g}}_j \cdot {\mathbf{z}}+ u^L({\mathbf{x}},j) > u^L({\mathbf{x}},j).$$

-   ${\mathbf{y}}\in \Delta^{m-1}$: For $i \in B$, we immediately obtain that ${\mathbf{e}}_i \cdot {\mathbf{y}}= {\mathbf{e}}_i \cdot ({\mathbf{y}}^*+\delta {\mathbf{z}}) \geq {\mathbf{e}}_i \cdot {\mathbf{y}}^* = \beta_i$, which means that these boundary conditions are satisfied. For $i \in [m] \setminus B$, we know that ${\mathbf{e}}_i \cdot {\mathbf{y}}^* > \beta_i$ and thus by picking $\delta1) {\mathbf{g}}_k \cdot ({\mathbf{y}}-{\mathbf{y}}^*)\\
&= -V.\end{aligned}$$ However, by we also have ${\tilde{u}^F}({\mathbf{y}},\ell) = -u^L({\mathbf{y}}, \ell)$ if $\ell \in \widehat{S}$, which implies that for all $\ell \in \widehat{S}$ it holds that $${\tilde{u}^F}({\mathbf{y}},j) \ge - V > -u^L({\mathbf{y}}, \ell) = {\tilde{u}^F}({\mathbf{y}},\ell).$$ Hence, ${\widetilde{{\textit{{BR}}}}}({\mathbf{y}}) \cap \widehat{S} = {\varnothing}$, which contradicts our assumption.

Robustness with Respect to Equilibrium Selection {#sc:strong}
================================================

As discussed in Section \[sec:prelim\], a weakness of BR- and payoff-inducible strategy profiles is that the resulting games may have multiple SSEs, in which case the follower depends on the leader to choose the SSE that maximizes his utility. To avoid this, in this section, we turn our attention to strong inducibility (see Definition \[def:strong-inducible\]) and attempt to find a payoff matrix ${\tilde{u}^F}$ such that $\widetilde{\mathcal{G}}$ has a unique SSE.

We begin with an example showcasing that,


1, 0.5) ; at (axis cs:0.15, 1.02, 0.55) [${\mathbf{y}}^*$]{};

The problem in Example \[exm:degenerate\] stems from the following observation: if the follower reports a payoff matrix such that strategy $1$ is the unique best response for all points in the domain, then there are multiple SSEs. This can be thought of as a “degenerate” case, since it would occur with probability $0$, if the payoffs of the leader were drawn uniformly at random in $[0,1]$. We formalize this as follows.

\[def:degenerate\] A leader payoff matrix $u^L$ is said to be *max-degenerate*, if there exists $j \in [n]$ such that $|\operatorname*{argmax}_{i \in [m]} u^L(i,j)| > 1$.

We next provide an example showing that even when $u^L$ is *not* max-degenerate, we cannot hope to *exactly* achieve the optimal inducible utility via a strongly inducibleignited “grass fires.” However, the water cannon was not specifically used to extinguish the fires. The water cannon was directed at water protectors.

Video shows the water cannon as police directed it at nonviolent water protectors. The video, shot with a drone, was at one point shot at with a water cannon presumably to knock it out of the air. The camp indicated police “shot down three media drones and targeted journalists with less lethal rounds.”

Unicorn Riot, a volunteer-operated collective of multimedia artists and journalists that has been on the ground documenting Standing Rock resistance for months, reported on the scale of the force used against water protectors as well as the impact on protectors.

The collective indicated there were serious injuries, including “one person who was badly injured after


being shot in the head with a rubber bullet.” A girl, who is 13 years-old, was reportedly shot in the face and suffered lung and eye irritation from the tear gas. There were multiple reports of cardiac arrest. One of Unicorn Riot’s reporters “had their press badge shot off when shot in the abdomen by a rubber bullet.” Multiple individuals suffered seizures. At least 300 water protectors suffered injuries, according to medics.

As Unicorn Riot reported, police “formed a line with armored vehicles, concrete barriers, and razor wire.” The police unleashed a plume of water on hundreds of people for hours, who chose to stand their ground but also in a sense were trapped because of how the police established a perimeter limiting where they could disperse.

For hours, Kevinobtained ranged between 1.8 × 10(-11) and 4.2 × 10(-9) cm(2)/s. A very good correlation between experimental and estimated data was obtained, and consequently the model could be used to predict the release of ferulic acid into food simulants and real food samples.


  * Performs GET http request.
     * @param path
     */
    public async get(path: string): Promise<Response> {
        return this.sendJSON('GET', path, null);
    }

    /**
     * Performs DELETE http request.
     * @param path
     */
    public async delete(path: string): Promise<Response> {
        return this.sendJSON('DELETE', path, null);
    }
}
been characterized. The first one concerns 95% of the patients and is located in the sub-telomeric region of chromosome 4 \[[@pone.0116853.ref005]--[@pone.0116853.ref007]\]: control individuals carry 11 to 100 repeats of a 3.3 kb tandemly repeated sequence named D4Z4, whereas FSHD1 patients carry only 1 to 10 repeats \[[@pone.0116853.ref008]\]. The second locus is located on chromosome 18 and is mutated in 80% of patients, referred to as FSHD2, in whom mutations in the SMCHD1 gene have been found \[[@pone.0116853.ref009]--[@pone.0116853.ref011]\]. In both FSHD1 and FSHD2 patients, a chromatin relaxation has been noted, associated with the de-repression of the DUX4 transcription factor DUX4 (reviewed by \[[@pone.0116853.ref012], [@pone.0116853.ref013]\]). However, the molecular mechanisms leading to FSHD are still not fully understood and need to be deciphered. We have recently shown that some molecular hallmarks


15 and C24) during development. This suggests that the D4Z4 contraction does not impact myomiR expression, unlike in Duchenne Muscular Dystrophy (DMD) where miR-1, miR-133a, and miR-206 were highly abundant in the serum of DMD patients but down-regulated in muscle \[[@pone.0116853.ref029], [@pone.0116853.ref030]\]. At first view our results could seem to be in contradiction with previous results showing that miR-133a is up-regulated in FSHD2 myoblasts derived from an adult quadriceps \[[@pone.0116853.ref031]\]. However, these data were obtained *in vitro* whereas our assays were performed *in* vivo, on FSHD1 fetal muscle biopsies where we have already shown that *DUX4* and DUX4 downstream target genes are expressed \[[@pone.0116853.ref014], [@pone.0116853.ref015]\]. Interestingly, this also strongly suggests that in FSHD1, *DUX4*-dependent transcriptional activation has no impact on myomiRs expression levels.

![Expression of myomiR in fetal muscleto be modulated during porcine muscle development \[[@pone.0116853.ref035]\]. Similarly, we did not find any difference in miR-214 expression during human muscle development, although it has been reported to promote the slow muscle phenotype in zebrafish \[[@pone.0116853.ref045]\] suggesting that it could have been up-regulated during secondary muscle fiber formation. We also detected some differentially expressed miRNAs during human skeletal muscle development, such as miR-224, and miR-381, which have not yet been associated with muscle formation.

Our results also identify a number of differentially expressed miRNAs that could represent new regulatory factors in muscle growth and development. Overall, these findings highlight the concept of a species-specific miRNA signature during muscle development. The fact that the miRNAs are differentially expressed during the different stages of muscle development confirms the complexity of this


Antoine Bibeau

Antoine Bibeau (born May 1, 1994) is a Canadian professional ice hockey goaltender currently playing for the Colorado Eagles of the American Hockey League (AHL) while under contract to the Colorado Avalanche of the National Hockey League (NHL). Bibeau was selected by the Toronto Maple Leafs in the sixth round, 172nd overall, of the 2013 NHL Entry Draft.

Playing career
As a youth, Bibeau played in the 2006 and 2007 Quebec International Pee-Wee Hockey Tournaments with the Victoriaville Tigres minor ice hockey team.

Bibeau played in the Quebec Major Junior Hockey League (QMJHL) from 2011 to 2014, where in his final year of major junior hockey he led the Val-d'Or Foreurs to capture the 2014 President's Cup and was recognized for his outstanding play when he was awarded the Guy   int array1[__builtin_offsetof(AnonymousUnion<T>, f) == 0? 1 : -1];
    int array2[__builtin_offsetof(AnonymousUnion<int>, f) == 0? 1 : -1];
  }

  template void test_anon_union<int>();
}

namespace AddrOfClassMember {
  template <typename T> struct S {
    int n;
    static void f() {
      +T::n; // expected-error {{invalid use of member}}
    }
  };
  void g() { S<S<int> >::f(); } // expected-note {{in instantiation of}}
}


man since 2000; nevertheless, there were and are many things I do not know.

It also didn’t take long to figure out that Michelle was and is . . . mentally and emotionally like a teenager (even though she is only about 2 or 3 years my junior).

Michelle told me she had an ex-husband, a full deaf person and a young daughter, Lori. At that time she, Lori, was only 10-years-old. I told Michelle I’d love to meet her as I enjoy working with children. Lori is hearing.

Michelle asked me some questions about Lori and how to talk to her about . . . important matters. Michelle and her ex-husband had grown-up attending deaf schools and had no clue about public schools. I happily volunteered, at Michelle’s approval, toher mother. Her father has been the full custodial parent since she was very young. A couple of years ago, Lori decided she didn’t want to see Michelle anymore.

There are many reason why . . . and they are all valid! Let me tell you!!! But, Michelle is another story for another time. Not only is she HOH, she’s also, as I stated, emotionally and mentally about 14-years-old. An irritating, disturbed 14-year-old.

Lori was older than her own mother by the age of 11 or 12, if not before!

Michelle will tell you that I did that to her daughter . . . or her father. She cannot and will not ever believe it is her and her actions. But, it is.

Now the happy times begin:

Her train arrived on time


Law of Attraction

To achieve the manifestation of the greater good, a spell might be cast, a blood-letting undertaken, a sacrifice made, or a dream incubated. For example, the shamans of several Native American tribes underwent vision quests, performed shamanic healings, sat in sweat lodges, and engaged in sun dances. They chanted incantations to ward off attacks by aggressive Europeans. That’s not to say that they always got what they wanted because the law, when opposite poles of attraction are set up, responds to the more powerful vibrational pull or yields a less strong or, in some cases, a mixed result. Native Americans performed incantations but were still attacked and lost battles to their powerful enemies whose forces, goals, and intentions proved stronger.

Yesterday, I spoke of some of mygifts . . .

Since it is day 87, it reminded me of 1987 as that was a pivotal year for me, regarding spirituality, Law of Attraction and beginnings and endings.

Most of it began pretty early on, February 1987. My father has been ill, with cancer and a strange accident in the hospital in October or November and wasn’t expected to live. He was laying, in an open-eyed coma at the Veteran’s Administration Hospital in Phoenix, AZ. I was back in Astoria (Queens), New York waiting to hear from Mom of any changes.

At Christmas, I flew home to visit with my parents. Daddy was already in the Veteran’s Hospital. A couple of months earlier, when, after a major surgery to remove his lung and part of his jaw —


in the group through around titles such as THE PENIS MONOLOGUES, and had found it was taken. We’ve had other festivals at Manhattan Theatre Source, i.e. for 11 years, ESTROGENIUS; which celebrates women-themed plays and/or women playwrights: And the recent INGENIUS; celebrating some of the work from the Writers Forum. Thus, they came up with TESTOGENIUS and my play is in it.

ESTROGENIUS does the same thing . . . they allow men playwrights as long as the play is about women’s themes.

As I write this, nevertheless, it is already near the end of June (June 24th to be exact) and we in the middle of the production of TESTOGENIUS, which I’ll write even more about soon.

At the reading, on this day . . . which I’m recalling. Myany job . . . McDonald’s, etc. And still, excuse after excuse, about how he cannot do that . . . he’s too educated, too disabled. Of course, the government won’t give him disability because doctors find nothing wrong with him. This went on for months and months, maybe a year.

I told him, logical deduction, lose weight and your self-diagnosed disability would ease. Then, he would send me pages and pages of email as to why I’m wrong. All negative bullshit.

Finally, after all this, I wrote him an email . . . because even after I quit writing back, and saying nothing . . . he continued to send me diatribe after diatribe of why I am wrong about him. I told him to stop writing to me.


or
Trustee shall receive reasonable compensation, taking into account the
nature and extent of the services rendered.
	In reviewing the preceding provision, we must consider the context of the entire will
while carefully examining the words specifically chosen by the testator.  See Lang, 35
S.W.3d at 639; see also Welch, 531 S.W.2d at 321; Johnson, 840 S.W.2d at 672; Mullin,
773 S.W.2d at 410.  May Glen's will clearly provides that her husband, while serving as
executor and co-trustee, "shall receive no compensation." It also provides that "my
individual Co-Trustees shall receive no compensation."  It is clear that, in using the term
"[c]o-trustees," May Glen intended for those individuals serving as co-trustees with her
husband to "receive no compensation." (10)
  That is not the case in this dispute.  Had May
Glen intended to preclude BigbeeThe impact of preinjury antithrombotic medication on hemostatic interventions in trauma patients.
The purpose of this study was to determine whether preinjury medication with antithrombotic agents was related to an increase in hemostatic interventions in patients with severe trauma without traumatic brain injury. Consecutive trauma patients who were admitted to the emergency departments of the study hospitals with an injury severity score ≥16 were enrolled in this retrospective, observational, multicenter study of coagulation in the acute phase of severe trauma. Patients without a traumatic brain injury with an abbreviated injury scale ≥3 were evaluated. Patients were divided into those with and those without preinjury medication with antithrombotic agents. The impact of preinjury antithrombotic medication on the composite primary outcome, defined as administration of fresh frozen plasma ≥10 U and/or


Lck, Blk, Lyn, Hck, Yrk and Fgr. Src is a non-receptor protein tyrosine kinase and its activation is mainly regulated by phosphorylation at the tyrosine 416 residue \[[@B10]\]. Src signalling has been implicated in a variety of cellular processes, including cell growth, survival, cellular transformation and motility \[[@B11],[@B12]\]. For the first time, in the present study, we investigated the role of Src kinase in *A. castellanii*.

Methods
=======

All chemicals were purchased from Sigma (Poole, Dorset, UK), unless otherwise stated.

Culturing of *Acanthamoeba castellanii*
---------------------------------------

An *A. castellanii* isolate belonging to the T4 genotype was obtained from the American Type Culture Collection (ATCC50492), and sourced from a keratitis patient. The cells were grown axenically in 10 ml of PYG medium \[0.75% (w/v) proteose peptone, 0.75% (w/v) yeast extract and 1.5% (w/v) glucose\] (Oxoid Ltd., Basingstoke,At the end of this incubation period, supernatants were collected and cytotoxicity was determined by measuring lactate dehydrogenase (LDH) release (cytotoxicity detection kit; Roche Applied Science, Lewes, East Sussex, UK). Briefly, conditioned media of co-cultures of *A. castellanii* and HBMEC were collected and percentage LDH was detected as follows: (sample value -- control value/total LDH release -- control value x 100 = % cytotoxicity). Control values were obtained from HBMEC incubated in RPMI alone. Total LDH release was determined from HBMEC treated with 1% Triton X-100 for 30 min at 37 °C.

*Acanthamoeba* Src kinase identification and sequence alignments
----------------------------------------------------------------

Putative *Acanthamoeba* Src kinase protein was searched in *Acanthamoeba castellanii* genome database, hosted by The Human Genome Sequencing Center, Baylor College of Medicine (http://blast.hgsc.bcm.tmc.edu/blast.hgsc?organism = AcastellaniNeff), using closely related *Monosiga brevicollis* Src1 kinase protein sequence (NCBI accession


(a)** Domain architecture of human c-Src kinase. The two important regulatory phosphorylation sites (Y419 and Y530) are marked. **(b)** Putative *Acanthamoeba* Src kinase (AcSrc) sequence was aligned with *Drosophila melanogaster* c-Src (DmSrc), *Caenorhabditis elegans* Src (CeSrc), *Ephydatia fluviatilis* Src related protein (EfSrc), *Monosiga brevicollis* Src1 (MbSrc), *Hydra vulgaris* (HvSrc) and *Homo sapiens* cSrc (HsSrc). The SH3, SH2 and catalytic domain are indicated with yellow, blue and green bars above the sequence, respectively. Asterisk (\*), colon (:) and period (.) marks the region of conserved, strongly similar and weakly similar residues, respectively. Whereas black diamond represents residues involve in ATP binding; black arrowheads represents residues form hydrogen bond with PP2, and black circles indicates the Y419 and Y530 phosphorylation sites in human cSrc, most of which are also conservedin AcSrc.](1756-3305-5-112-6){#F6}

Recent studies have shown that *Acanthamoeba* exhibits multifactorial virulence properties to produce damage of HBMEC, which constitute the blood--brain barrier, to produce encephalitis and corneal epithelial cells to induce keratitis \[[@B4]\]. Here, we studied the role of Src kinases on the biology and pathogenesis of *Acanthamoeba*. The findings revealed that Src kinase inhibitor, PP2, but not its inactive analog, PP3, abolished *A. castellanii* proliferation. These findings indicate that Src kinases have a pivotal role in the growth of A. *castellanii*, which is consistent with some previous findings that showed that Src is an important signalling molecule involved in the growth of various eukaryotic cell types \[[@B11],[@B12]\]. Src kinases act on a number of substrates in the cell, including enzymes involved in phospholipid metabolism, such as the p85


reduced A. *castellanii* phagocytosis of non-invasive K-12 with an increase in the concentration of PP2, while opposite effects were observed for invasive *E. coli* K1. A likely explanation is that *E. coli* K-12 is a food source for amoebae. In such situations, the process of bacterial uptake is most likely to be "driven" by *A. castellanii*, which would be dependent on amoeba intracellular signal transduction pathways involving Src kinases. In contrast, neuropathogenic *E. coli* K1 is an invasive strain. Their invasion of *A. castellanii* is most likely reliant on bacterial invasion, which might explain the involuntary uptake of *E. coli* K1 by *A. castellanii*, as observed in the present study. However, this contrasts with results of previous studies \[[@B16],[@B28],[@B29]\], which showed the involvement of Src in *Staphylococcus aureus*-invasionQ:

HTTPAsyncClient skipping the first time

I am using HTTPAsyncClient to send a post request to the server , and it is activated with a button press (named checkbox) the problem is now when I press the first time It skips going into the TextHttpResponseHandler() and so it doesn't send anything to the server , but on the second press It gets into the function normally and calls the server , also when I switch to another activity it does the same thing and skips going into the response
handler.
EDIT: I was debugging the program and I realized it does not skip the part as much as for the first run , it does not call the server at all , and returns the server_response=null but on the second call


     password_ET.setError("Password has to be 6 characters or more");
        return false;
    } else {
        password_ET.setError(null);
    }

    if (!confirm_password.equals(password)) {
        confirm_password_ET.setError("Password does not match");
        return false;
    } else {
        confirm_password_ET.setError(null);
    }

    if (phone.length() < 11) {
        phone_ET.setError("Phone number invalid");
        return false;
    } else {
        phone_ET.setError(null);
         }
        if (response.contains("PHONE_INVALID")) {
            error_message = error_message + " Invalid Phone";
        }
        if (response.contains("NAME_INVALID")) {
            error_message = error_message + " Invalid Name";
        }
        if (response.contains("DOP_INVALID")) {
            error_message = error_message + " Invalid DoP";
        }
        if (response.contains("USERNAME_INVALID")) {


 *          \frac{1}{n} \sum\limits_{n=1}^N (\hat{p}_n - p_n)
   *      @f$
   *   -# @f$ (N \times 1 \times 1 \times 1) @f$
   *      the labels -- ignored as we can't compute their error gradients
   */
  virtual void Backward_cpu(const vector<Blob<Dtype>*>& top,
      const vector<bool>& propagate_down, const vector<Blob<Dtype>*>& bottom);
  virtual void Backward_gpu(const vector<Blob<Dtype>*>& top,
      const vector<bool>& propagate_down, const vector<Blob<Dtype>*>& bottom);

  /// The internal SigmoidLayer used to map predictions to probabilities.
  shared_ptr<SigmoidLayer<Dtype> > sigmoid_layer_;
  /// sigmoid_output stores the output of the SigmoidLayer.
  shared_ptr<Blob<Dtype> > sigmoid_output_;
  /// bottom vectorresults for NCCO and PCCO underscore the need for a phase-sensitive experiment[@symmrev]. Tricrystal phase-sensitive experiments[@triprl] have established $d$-wave pairing symmetry for many of the optimally hole-doped cuprate superconductors. However, such experiments are difficult in the electron-doped superconductors because of the difficulty in making grain boundary Josephson junctions with sufficiently large critical currents. As reported in the literature, the critical current density J$_c$ decreases exponentially with increasing grain boundary misorientation angle $\Theta$ for all cuprates, and can be described by the generic formula[@hilgenkamp]: $$J_c(\Theta)=C_i e^{-\Theta/\Theta_i}$$ where C$_i$ $\sim$ 4.4$\times$10$^7$A/cm$^2$ and $\Theta_i\approx$5$^o$ for hole-doped superconductors, and C$_i$ $\sim$ 1.8$\times$10$^6$A/cm$^2$ and $\Theta_i\approx$2$^o$ for electron-doped superconductors. Despite a similar angular dependence, the J$_c$ values can differ widely between electron- and hole-doped cuprates, especially for high-$\Theta$ grain boundary junctions. The original tricrystal configuration(Fig.


DDV_MinMaxLongLong(
    CDataExchange* pDX,
    LONGLONG value,
    LONGLONG minVal,
    LONGLONG maxVal);
```

### Parameters

*pDX*<br/>
A pointer to a `CDataExchange` object. The framework supplies this object to establish the context of the data exchange, including its direction.

*value*<br/>
A reference to a member variable of the dialog box, form view, or control view object with which data is validated.

*minVal*<br/>
Minimum value (of type LONGLONG) allowed.

*maxVal*<br/>
Maximum value (of type LONGLONG) allowed.

### Remarks

For more information about DDV, see [Dialog Data Exchange and Validation](../../mfc/dialog-data-exchange-and-validation.md).

### Requirements

  **Header** afxdd_.h

## <a name="ddv_minmaxmonth"></a> DDV_MinMaxMonth

Call `DDV_MinMaxMonth` to verify that the time/date value in the month calendar control ( [CMonthCalCtrl](../../mfc/reference/cmonthcalctrl-class.md)) associated with *refValue* falls between *refMinRange* and *refMaxRange*.

```cpp
void AFXAPI DDV_MinMaxMonth(
    CDataExchange* pDX,
    CTime& refValue,
   anyone using the woozle of “Illustrative purposes” and knowing that it’s such a poor illustration either likes its cartoon nature, or they think the people hearing it need to be treated like children.

There is a name in the field of Domestic Violence that keeps on coming up everywhere you go in the UK. It’s Prof. Sylvia Wallby, holder of the UNESCO Chair in Gender Research at the University of Lancaster. Whenever the government needs an expert Sylvia is the one they call. It’s fascinating too, because when you listen to her it’s clear she is also an expert tap dancer.

She makes a most interesting and pointed comment about the British Crime Survey and Questions about Domestic Violence being asked. Now that little bread crumb led to pay dirt


leakage occurs

Any immoral or offensive materials - including anything relating to gambling such as lottery tickets or betting advertising

Paintings and drawings of an indecent or obscene nature

Seven Seas Worldwide are here to help with any queries you may have. We have a friendly and helpful team ready to take your call on 1 877 817 7327. And don't forget to check out our instant online quote engine and take advantage of our great offer of $169 for 2 Large Boxes (30kg each box).All eyes are on these 20 remarkable young women who are taking Arizona by storm. Whether they started a highly successful custom jewelry business at the age of 14 or founded a school that provides public charter education to children who need it the most, these wonder women work hard, give back and are having a great time doing so.


Fumes

Thanks Jeff, I remembered this myself John and I've shared it with all the boys at work.Before reading this I'd welded metal at work many, many times after cleaning it with Brakekleen. I've been lucky since I get really close while welding, it won't happen anymore.

Re: Welding Fumes

Sun Nov 04, 2012 5:45 pm

Back in the 80's I recall reading an article in Firehouse Magazine about a tragic death from chemical poisoning of a little girl. To the best of my recollection, it went something like this:

The girls dad, a volunteer or paid part time firefighter responded to a call at a feed mill or some sort of fertilizer joint in the wee hours of the morning. It was either a squad call or a fire run in whichwearing dirty work clothes around the house after coming in contact with chemicals at work or on the farm.

Re: Welding Fumes

Sun Nov 04, 2012 7:16 pm

It was one of the WWI poison gases. Another danger is welding galvanized. The zink can be nasty.


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Here is a very interesting “did you know” fact about Coronado. Sure, many of you know that the sand dunes on Central beach spell out the word C-O-R-O-N-A-D-O, but do you know why they were created, how they were created and who the artist is that created them?

Exactly 30 years ago, on Martin Luther King Jr. Day in 1988, Armando Moreno (City of Coronado employee) was tasked with cleaning up the massive amounts of kelp that washed onto Coronado beaches due to a high tide. Armando decided to bury it in the sand and add ice plant to the top of it to create a series of letters. This took place over a two year process. His masterpiece was created, but it wasn’t until Google Earthsatellite photos appeared online that anyone (besides Navy pilots) knew about his creation.

- Advertisement -

Not only is it an amazing piece of “sand art”, but many Navy sailors and Jr. Lifeguards train and exercise across those very dunes – they may or may not be pleased with Armando’s creation!

After a story in 2011 about these dunes and Armando, it was learned that he had never seen the dunes from above. So, a local pilot, Britt Cooper, took Armando up in the air to admire them from above. The video from that flight is below:

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Now you know the why, how and who regarding the C-O-R-O-N-A-D-O sand dunes. Another reason that makes Coronado such a special place.


to carry, fits in your hand perfectly and had a good battery life.

The included vape tank has the capacity of holding 8 ml of vape juice. Really it is a very large vape tank. So you can get long-lasting vaping sessions.

This box mod is very powerful with 230 watts. So it is a boon for the advanced vaper who needs a lot of vapor. Also, it comes with everything you can start vaping. So definitely the best bang for your budget!

Features and Specs

SMOK G-Priv 2 Luxe Edition Touch Screen Mod

High-Grade Zinc Alloy Construction

Minimum Atomizer Resistance: 0.06ohm

Supports Ni200 (Nickel), Titanium & Stainless Steel Heating Elements

TCR Adjustments (Temperature of Coefficient Resistance)

Temperature Range: 200-600F

Wattage Output Range: 1-230W

5 Draw Settings: Min, Max, Soft, Normal, Hard

Dual Magnetized Battery Access Door

IPS 200PPI Vibrant DisplayYou have your Promise training wheels now, but lets loosen them up a little. What if I told you .then() returns a Promise too, and that new Promise resolves to whatever its callback return s? No ifs about it, it’s the truth! If that was confusing, read it once or twice more, and then check this out:

const g = Promise.resolve(3).then((three) => { return 4; });

What is g ? If you said a Promise, you’d technically be right! We’re calling .then() and I just said that returns a Promise. BUT, what does g resolve to? In English, the code above is putting 3 in a box, then opening that box and passing the contents (3) to the .then , who promptly ignores it and returns 4. .then takes that


.catch . Just like .then , it returns a Promise that resolves to the return value its handler returns. This means that a .catch handler that runs successfully ‘moves’ the Promise from a rejected state to a resolved state. .then s after a .catch will run until another error is thrown, or a handler returns a rejected Promise.

const m = Promise.resolve(3)

.then(() => console.log('yup'))

.then(() => console.log('also yup'))

.then(() => { throw new Error('Oh no!'); })

.then(() => console.log('nope...'))

.catch(() => console.log('Consider that error HANDLED'))

.catch(() => console.log('nope... we\'re resolved now'))

.then(() => console.log('We\'re back on track now!')); // -> "yup"

// -> "also yup"

// -> "Consider that error HANDLED"

// -> "We\'re back on track now!"

Notice that our .then after the thrown error doesn’t run, because the promise is rejected at that point. Since the following= require('fs'); const myLittlePromise = new Promise((resolve, reject) => {

// Resolve if things go ok, or reject if things go awry.

// (Throwing would work too)

fs.readFile('/etc/passwd', (err, data) => {

if (err) {

return reject(err);

}

return resolve(data);

});

});

The Promise constructor takes a handler function that receives both resolve and reject callbacks as arguments. Do whatever work inside the hander you like, and call the appropriate callback when you’re done. In this example we wrap up fs ‘s callback based readFile in a Promise all our own.

Sources/Inspiration/Further Reading

Some of these examples, especially around chaining, are simplified so it’s easier to get the gist of what the final result is. I hand wave over the fact that each step in the chain is a new Promise. This means were you to save those intermediate Promises


The charge-sheet filed in the Pehlu Khan case says that Pehlu and his two sons were accused of cow smuggling. However, the media along with the opposition politicians created a fracas over the issue, with many demanding that his name be dropped from the charge-sheet as he was a victim of an onslaught by Gaurakshaks. He and his sons were accused of being cow smugglers. However, his alleged crimes were whitewashed and he was portrayed by a certain section of media and a group of self-declared intellectuals as a man of noble character who was murdered in a cold-blood by Hindutva goons and Gaurakshaks.

Such media shenanigans of calling cow smugglers as cow movers are carried out to render the actual and serious issue of cow smuggling unimportant. Byaddress, and caching the memory type in the TLB in association with the virtual address.
In another aspect, it is a feature of the present invention to provide a method of providing a memory type for a physical address range in a microprocessor. The method includes caching a plurality of physical addresses translated from a plurality of virtual address in a translation lookaside buffer (TLB) based on virtual addresses, and caching in the TLB a plurality of memory types associated with the plurality of physical addresses. The method also includes applying a virtual address to the TLB, and providing one of the plurality of memory types cached in the TLB associated with one of the plurality of physical addresses based on the virtual address applied to the TLB.
An advantage


protein kinases (MAPK) signaling pathway. Taken together, baicalein had potential to suppress the adhesion, migration and invasion of MDA-MB-231 cancer cells in vitro and it could serve as a promising drug for the treatment of cancer metastasis.potential injection wells. Because smaller faults can escape detection, seismic monitoring arrays should be deployed in the vicinity of injection wells when there is a cause for concern that injection might trigger seismicity.

The locations and magnitudes of naturally occurring earthquakes are routinely determined on a real-time basis in numerous seismically active regions around the world. The instrumentation, data telemetry and analysis techniques used to accomplish this monitoring are well developed and easily implemented at relatively low cost. By supplementing regional networks with local seismic arrays near injection wells, accurate locations of earthquakes that might be triggered by injection can be used to determine the locations and orientations of the causative faults.

Although small faults cannot cause large earthquakes, even small earthquakes felt by the public will be a cause


for concern and should be monitored.

Step 4: Establish Modification Protocols in Advance

Following precedents established to deal with earthquakes triggered during the development of enhanced geothermal systems, operators and regulators should jointly establish operational protocols for injection sites located in areas where there is concern about the potential for triggered seismicity. These protocols are sometimes referred to as “traffic light” systems.

Green means go: Once operational protocols and local seismic networks are in place and injection begins at agreed-upon rates, operators would have a green light to continue unless earthquakes begin to occur that appear to be related to injection. The occurrence of seismicity would be a cautionary yellow light. Once seismicity occurs, operators would slow injection rates and study the relationship between the seismicity and injection. Should seismicity cease,capable of producing a moderate-sized earthquake. In the case of the Arkansas triggered earthquakes, as well as a series of quakes thought to have been caused by wastewater injection in the Barnett Shale in Texas near the Dallas-Fort Worth metro area in 2008, the seismicity abated once injection in the problematic wells was terminated.

Overall, it is important for the public to recognize that the risks posed by injection of wastewater are extremely low. In addition, the risks can be minimized further through proper study and planning prior to injection, careful monitoring in areas where there is a possibility that seismicity might be triggered, and operators and regulators taking a proactive response if triggered seismicity were to occur.


Assays {#s2d}
------------------------

Binding of 5-LOX to His~6~-tagged PEDF-R polypeptides was assayed by pull-down with Ni-nitrilotriacetic acid (NTA) resin as indicated in the legends. Western blotting was against anti-5-LOX antibodies (Pierce, Waltham, MA, USA) diluted 1:10,000 in 1% BSA and horseradish peroxidase (HRP)-conjugated goat anti-rabbit IgG (1:100,000 in 1% BSA), and detection was with West Dura (Thermo Scientific, Waltham, MA, USA) followed by exposure of blot to X-ray film.

Cell Cultures {#s2e}
-------------

Human ARPE-19 cells (passages 27--40; American Type Culture Collection, Manassas, VA, USA) were cultured in DMEM/F-12 medium (cat. no. 11330-032; Gibco, Grand Island, NY, USA) supplemented with 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin. Cell line short tandem repeat (STR) analysis to validate ARPE-19 cell line was performed at bioSYNTHESIS, and no contamination was detected. Cultures were incubated atwells per experiment ± SD (*error bars*). LTB~4~ level in each well was measured in triplicates. Each experiment was performed twice. \**P* ≤ 0.05.](i1552-5783-57-11-4581-f06){#i1552-5783-57-11-4581-f06}

Effect of Silencing and Overexpression of PEDF-R Under Oxidative Stress {#s3h}
-----------------------------------------------------------------------

The above results suggest that peptide P1 can modulate the 5-LOX activity in RPE cells. To further explore this modulation, the *PNPLA2* gene was silenced and overexpressed in ARPE-19. The cells were exposed to oxidative stress, followed by the determination of the levels of LTB~4~ in the culturing media. In the absence of oxidative stress, the levels of LTB~4~ in ARPE-19 cells showed no significant change. However, oxidative stress increased the LTB~4~ levels by \>10-fold in cells that were transfected with si*SCR*, si*PNPLA2*, or those that were not transfected ([Fig. 7](#i1552-5783-57-11-4581-f07){ref-type="fig"}A). Overexpression of *PNPLA2* prevented


Neuroligin binds its presynaptic ligand neurexin to modify synaptic functions in the brain. Disruption in the neuroligin signaling pathway is associated with devastating disorders like autism, schizophrenia, fragile X syndrome and others. However, little is known about how neuroligin signaling modifies neural circuit function and animal behavior. A complete understanding of this process requires thorough characterization of neural circuits and their components along with the ability to measure and more importantly perturb their activity. Invertebrate circuits with their well-defined neuroanatomy and quantitative behaviors are ideal to decipher the neuroligin signaling mechanisms underlying complex outputs. The nematode, Caenorhabditis elegans, with its nervous system comprising of just 302 neurons with identified connections and highly conserved synaptic machinery provides an unique opportunity to analyze genes, cells and circuits regulating complex behaviors.gene variants and neurexin in influencing neural circuit functions (Aim 2). Finally, they will modify an automated imaging platform to perform novel neural activity based genetic screens and identify components of the NLG-1 signaling pathway (Aim 3). These studies will clarify how neural circuits integrate information at the level of synapses, neural circuits and whole organisms and identify candidates relevant to human disease.


Brush-based self-sampling in combination with GP5+/6+-PCR-based hrHPV testing: high concordance with physician-taken cervical scrapes for HPV genotyping and detection of high-grade CIN.
Studies have shown that self-sampling for hrHPV testing (HPV self-sampling) is highly acceptable to women, increases screening participation rate, and may therefore further reduce cervical cancer incidence. However, it is important to clinically validate HPV self-sampling procedures for screening purposes. Clinical validation of combined brush-based self-sampling with GP5+/6+-PCR EIA for primary cervical screening. In addition, HPV type-specific agreement between sample types and acceptability of brush-based self-sampling were evaluated. 135 women referred for colposcopy took a self-sample at home prior to vaginal- and cervical sampling by a gynaecologist. All women were biopsied for histology. HPV testing was done by GP5+/6+-PCR EIA, with genotyping by reverse line blotting (RLB).Transformers have no moving parts and rarely fail. What goes is the timer, the switch, etc. I have a 300 watt Malibu and they cost almost $100. So when mine failed after about 3 years, I opened it up, cut the wires that went to the timer and the on/off switch, closed it back up and attached it to a $25 outdoor timer with a photo eye. Plugged it back in and bingo... Works just fine.

We’ve priced this item below the manufacturer’s suggested retail price, so you’ll have to add it to your cart to view this very low price . If you don’t want to purchase the item, you can remove it from your cart.


canChangeIcon: true) {
			state "closed", label: '${name}', action: "valve.open", icon: "st.valves.water.closed", backgroundColor: "#ffffff"
			state "open", label: '${name}', action: "valve.close", icon: "st.valves.water.open", backgroundColor: "#00A0DC"
		}
		standardTile("refresh", "device.switch", inactiveLabel: false, decoration: "flat") {
			state "default", label:'', action:"refresh.refresh", icon:"st.secondary.refresh"
		}

		main "contact"
		details(["contact","refresh"])
	}
}

def installed() {
	log.trace "Executing 'installed'"
	initialize()

	sendEvent(name: "contact", value: "closed")
}

def updated() {
	log.trace "Executing 'updated'"
	initialize()
}

private initialize() {
	log.trace "Executing 'initialize'"

	sendEvent(name: "DeviceWatch-DeviceStatus", value: "online")
	sendEvent(name: "healthStatus", value: "online")
	sendEvent(name: "DeviceWatch-Enroll", value: [protocol: "cloud", scheme:"untracked"].encodeAsJson(), displayed: false)
}

def open() {
	sendEvent(name: "contact", value: "open")
}

def close() {
	sendEvent(name: "contact", value: "closed")
}
Q:

Swap input and print output as column

I have set for myself a task that I am not able to complete. Need help.
What I am trying to achieve is user's input numbers should be swapped by pairs and if there is a comma separated numbers, next swap should output from a new row.
Like if I say: 10000234567,10000234568,10000234569 then output should look like this:
01002043657,
01002043658,
01002043659
Here's my code:
import java.util.Scanner;

public class SwapNumbersTest {

public static String swapPairs(String str) {
char[] arr = str.toCharArray();
for (int i = 1; i < arr.length; i += 2) {
  if(arr[i] == ','){
    i+=2;
  }
  char swap = arr[i];
  arr[i] = arr[i - 1];
  arr[i - 1] = swap;
}
return new String(arr);
}

public static void main(String[] args) {
Scanner sc = new Scanner(System.in);
System.out.println("Enter a comma separated


feel like I am slow at understanding code and seeing those “pragmatic” solutions that just get the task done, without the need of a huge refactor. I am well aware, that the code I produce in many cases is of better quality, but since the customer is concerned with what features get into the next sprint and long-term expensive quality improvements are not so easy to grasp and measure, the stuff I produce simply isn’t a good fit for the customers need. This makes me feel bad, because I am the uneasy guy who critiques the most (stupid build, shitty infra, bad code, bad design,..) but actually gets done the least...
I am convinced that writing and reading code are opposite forces: code that is easier to write, isRide Momentum Stocks to Quick Gains!
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Racial and ethnic differences in microalbuminuria prevalence in a diabetes population: the pathways study.
The objective of this study was to determine whether racial or ethnic differences in prevalence of diabetic microalbuminuria were observed in a large primary care population in which comparable access to health care exists. A cross-sectional analysis of survey and automated laboratory data 2969 primary care diabetic patients of a large regional health maintenance organization was conducted. Study data were analyzed for racial/ethnic differences in microalbuminuria (30 to 300 mg albumin/g creatinine) and macroalbuminuria (>300 mg albumin/g creatinine) prevalence among diabetes registry-identified patients who completed a survey that assessed demographics, diabetes care, and depression. Computerized pharmacy, hospital, and laboratory data were linked to survey data for analysis. Racial/ethnic differences in the odds of microalbuminuria and') for c in msg])

print(txt_2_morse("Hello World"))
# ......-...-..--- .-----.-..-..-..

So, if you want to read a file in line by line into an output file, you can simply parse each line individually.
with open('inputfile.txt') as infile:
    with open('outputfile.txt', 'w') as outfile:
        for line in infile:
            outfile.write("{}\n".format(txt_2_morse(line)))

Input:
this is a file
with a few lines in it
to demonstrate code

Output:
-......... ..... .- ..-....-...
.--..-.... .- ..-...-- .-....-..... ..-. ..-
---- -...------....-.-..--. -.-.---.


*
    * @discussion
    * This pure virtual member function, which subclasses must implement,
    * is called by an
    * @link //apple_ref/doc/class/OSCollectionIterator OSCollectionIterator@/link
    * object so that it can allocate the storage needed
    * for the iteration context.
    * An iteration context contains the data necessary
    * to iterate through the collection.
    */
    virtual unsigned int iteratorSize() const = 0;

   /*!
    * @function initIterator
    *
    * @abstract
    * Initializes the iteration context for a collection subclass.
    *
   * @abstract
    * Sets the storage increment of the collection.
    *
    * @result
    * The new storage increment of the collection,
    * which may be different from the number requested.
    *
    * @discussion
    * Subclasses must implement this pure virtual member function.
    * Most collection subclasses allocate their storage
    * in multiples of the capacity increment.
    *
    * Collection subclasses should gracefully handle
    * an increment of zero
    * by applying (and returning) a positive minimum capacity.
    *
    *


should be able to store.
    *
    * @result
    * The new capacity of the collection,
    * which may be different from the number requested
    * (if smaller, reallocation of storage failed).
    *
    * @discussion
    * Subclasses implement this pure virtual member function
    * to adjust their storage so that they can hold
    * at least newCapacity objects.
    * Libkern collections generally allocate storage
    * in multiples of their capacity increment.
             in options to change.
    *                 Pass 0 to get the whole current options bitfield
    *                 without changing any settings.
    * @param context  Unused.
    *
    * @result
    * The options bitfield as it was before the set operation.
    *
    * @discussion
    * Kernel extensions should not call this function.
    *
    *


is a must under it. Wish I could find more like this in other colors!
July 3, 2013

✝ By texting MOBILE to 23705, you agree to receive up to 10 text messages per month with information, alerts, and special offers from Lane Bryant. Messages may be sent in SMS or MMS format, and may be sent via automatic telephone dialing system. Your consent is not required and is not a condition of any purchase. You must be the mobile account holder, and be at least 18 years of age or have parental consent to participate. Lane Bryant will not charge you for subscribing to this program; however, MSG and Data Rates may apply. Text HELP for help, STOP to opt-out. You may receive a final message confirming your decision
198 S.W.3d 585 (2006)
KENTUCKY BAR ASSOCIATION, Movant,
v.
Bryan K. BURLEW, Respondent.
No. 2006-SC-000367-KB.
Supreme Court of Kentucky.
August 24, 2006.
Bruce K. Davis, Executive Director, Jenny Dawson Lafferty, Deputy Bar Counsel, Kentucky Bar Association, Frankfort, Counsel for Movant.
Bryan K. Burlew, Burlington, Counsel for Respondent.

OPINION AND ORDER
The Board of Governors of the Kentucky Bar Association (KBA) recommends that this Court adopt its findings of fact, conclusions of law, and recommendation to suspend Respondent, Bryan K. Burlew, Member No. 87529, of P.O. Box 336, Burlington, Kentucky, from the practice of law for 181 days for violations of SCR 3.130-1.1, SCR 3.130-1.4(b), SCR 3.130-5.5(a), SCR 3.130-8.1(b), SCR 3.130-1.3, SCR 3.130-1.4(a), SCR 3.130-1.16(d), SCR 3.130-8.3(c) and SCR 3.130-8.1(b).
With respect to File 10362, Respondent was charged on November 21, 2005, by the Inquiry Commission of the KBA with


circGprc5a siRNA or miR-1283 inhibitor. (**C**) Colony formation assay of HepG2 and Hep3B cells co-transfected with circGprc5a siRNA or miR-1283 inhibitor. (**D**) Flow cytometric analysis of HepG2 and Hep3B cells co-transfected with circGprc5a siRNA or miR-1283 inhibitor. Scale bar = 20 μm. \* vs-NC group (P\<0.05),\*\* vs si-NC group (P \<0.01), \#vs si-circGprc5a group (P \<0.05).

CircGprc5a Sponged and Sequestered miR-1283 to Upregulate YAP1/TEAD1 Expression {#S0003-S2005}
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Targetscan was used to search for potential targets for miR-1283 ([[Table S1](http://www.dovepress.com/get_supplementary_file.php?f=240261.xlsx)]{.ul}), both YAP1 and TEAD1 were predicted to be potential targets for miR-1283 ([Figure 5A](#F0005){ref-type="fig"}). The total potential targets were shown in the table of supplementary material. Luciferase reporter gene assay showed that miR-1283 overexpression significantly reduced luciferase activity of YAP1 and TEAD1 wild-type vectors, but there was no significant change in luciferasemuting miR-1283. (**A**) Putative binding sites for miR-1283 and YAP1 or TEAD1 3ʹ-UTR. (**B**) Analysis of luciferase activity in cells co-transfected with miR-1283 mimetic and YAP1/TEAD1 3ʹ-UTR-WT or YAP1/TEAD1 3ʹ-UTR-Mut vector. (**C**) YAP1/TEAD1 mRNA expression levels in cells co-transfected with miR-1283 mimetic and circGprc5a vector. (**D**) Expression levels of YAP1 and TEAD1 in liver cancer tissues. (**E**) Pearson correlation analysis of miR-1283 and YAP1/TEAD1 mRNA in liver cancer tissues (n = 64). \*\* vs control group (P \<0.01), \#vs circGprc5a group (P \<0.05).

In vivo Veriﬁcation of Inﬂuence of CircGprc5a/miR-1283/YAP1/TEAD1 on HCC Cell Growth {#S0003-S2006}
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Finally, the effect of circGprc5a on HCC progression in vivo was analyzed. The results showed that sh-circGprc5a inhibited tumor weight and tumor volume contrasted with si-NC group, miR-1283 inhibitor group increased tumor weight and tumor


adaptive array deployment in the near future.
Phased array antenna systems employ a plurality of individual antennas or subarrays of antennas that are separately excited to cumulatively produce an electromagnetic wave that is highly directional. The radiated energy from each of the individual antenna elements or subarrays is of a different phase so that an equiphase beam front, or the cumulative wave front of electromagnetic energy radiated from all of the antenna elements in the array, travels in a selected direction. The difference in phase or timing between the antenna's activating signals determines the direction in which the cumulative wave front from all of the individual antenna elements is transmitted. Analysis of the phases of return beams of electromagnetic energy detected by the individual antennas in the array similarlytime. As you can see, in my tests the vast majority of calls had a round-trip time of 3-4 ms, which is more than sufficient for most game applications (and in-line with standard wireless controller latency).

A secondary benefit of using a single WebSocket (as opposed to many web-service calls with their own sockets) is that the data is serialized and we don't have to worry about data arriving at the server in a non-deterministic order.

FAQ

Won't the mobile web browser UI get in the way?

This can happen with some browsers. I personally recommend using browsers that have a good fullscreen mode (like Atomic Web Browser Lite).

A touch screen on the controller diverts attention away from the action on-screen. Won't that hurt the overall experience?

Touch screens are probably not the


key presses via XInput and/or DirectInput

Simulate a mouse touchpad for navigating complex game menus

Detect key bindings or otherwise make it easier for users to map a given touch UI to their key bindings.

Conclusion

It's not much right now, but my hope is that if there are others like me out there, Pyroscaphe might gain some momentum and eventually lead to some really interesting and engaging gaming experiences.

Wednesday, August 21, 2013

Every now and then, I like to take stock of what's in my .emacs file. It reminds me of a bush in my yard. I see it so frequently that I don't notice it growing steadily over time. One day it just hits you that this thing is big and scraggly and needs to be trimmed way back.

I've learned theof the patients with visual symptoms or visual field deficits on presentation and stable in 24%. Mean follow-up was 45.1 months (range 3-120 months) with an 18% recurrence rate at a mean of 44.4 months (range 10-84 months). One patient was lost to follow-up. Thirty-six percent of patients received postoperative radiation to treat recurrence or residual tumor. Endocrine data are also presented. Craniopharyngiomas that originate within the sella below the diaphragma sellae are a select subtype characterized by 1) an enlarged sella, 2) an intact diaphragma sellae at surgery, and 3) an adamantinomatous pathology. These tumors can be treated transnasally without the absolute need for neurovascular flap reconstruction, as there is a low risk of CSF leakage.


Democratic presidential candidate former New York City Mayor Mike Bloomberg speaks during a “United for Mike,” event held at the Aventura Turnberry Jewish Center and Tauber Academy Social Hall on January 26, 2020 in Aventura, Florida.

Doggone it, Mike Bloomberg's presidential campaign is fast at producing funny ads.

Less than 24 hours after a video showing Bloomberg bizarrely shaking a dog's snout went viral on social media, his campaign released a digital ad featuring dogs endorsing the billionaire's candidacy for the Democratic nomination.

"Dog people get me," the former New York City mayor tweeted Wednesday, with the hashtag #DogsFurMike.

The pooches in the video, purporting to speak in human voices, bark about Bloomberg's various selling points.

One pup points out, "Mike's not afraid of the NRA, not one bit," referring to Bloomberg's support12-lead ECG was assessed at baseline and 90 min after the start of thrombolytic therapy. MaxSTE achieved a better combination of sensitivities and specificities for mortality prediction than sumSTR. The area under the receiver-operating characteristic curves for 180-day mortality prediction was 0.680 for maxSTE and 0.622 for sumSTR (difference 0.058; 95% CI 0.027-0.088). Risk groups categorised at low, medium, or high risk by maxSTE comprised 43%, 32%, and 24% of patients and those by complete, partial, or no sumSTR comprised 40%, 36%, and 24% of all patients. The 180-day mortality rates for the three maxSTE risk groups were 3.1%, 7.1%, and 16.2%, and those for the sumSTR groups were 4.8%, 8.1%, and 11.7%. The 12-month Kaplan-Meier estimates were 4.1%, 8.8%, and 18.6%, and 5.9%, 9.9%, and 13.7%, respectively.


             1.33;
@line-height-small:              1.5;

@border-radius-base:             4px;
@border-radius-large:            6px;
@border-radius-small:            3px;

@component-active-bg:            @brand-primary;

@caret-width-base:               4px;
@caret-width-large:              5px;

// Tables
// -------------------------

@table-cell-padding:                 8px;
@table-condensed-cell-padding:   tools like Kobold Fight Club, spreadsheets, and a head for numbers make it not too onerous to do this until you feel you don't need to any more.
2. "what is the range of CR that they can fight?"
Recall that CR is meant to be a statement that 4 equipped and rested adventurers of the same level as the CR should find the monster a "worthy" challenge (MM p.8, paraphrasing). So let's assume for the moment a party of 4 and a single monster, do the XP-math, and classify each encounter:

CR=Average Party Level (APL) usually yields a Medium encounter. (Recall the encounter descriptors in "Combat Encounter Difficulty" on DMG p.82.) The exceptions are at levels 5-7, where the "CR-appropriate" monster actually
yields an Easy encounter.

CR=APL-1 usually yields an Easy encounter.