a static Javascript file? CSS? Picture? Or is this a request that should serve a page, etc.?). In the case such as yours above, you want it to serve a particular page when hitting any URL that is not /favicon (so /.*), so what it does is takes any request to /.* and routes it to main.app, which is in your main.py file (I'm ignoring helloworld.app for now, mainly because in your situation you don't necessarily need it).
It is then that the more granular handling happens - main.app receives the original request, and then it looks for a specific handler to execute the code. When we change your handlers to r'/.*', it matches anything that comes in (so /, /hello, /helloworld, etc.), and it executes the correspondingyet.

Committee Chair Rep. Virginia Foxx, R-N.C., naturally crowed about HR4508, while claiming LBJ’s law is outdated and doesn’t work.

“The numbers do not lie: The tangled web of aid programs in existence today produced more debt than success,” Foxx claimed. “We can cut through the clutter and confusion students face…by presenting one grant, one loan, and one work-study program. Similarly, paring down the maze of loan repayment options to a standard 10-year repayment plan and an income-based repayment plan will let students come up with a plan for paying down their debt they know they can actually stick to.”

AFT, UAW, and the committee Democrats sharply disagreed with their scheme.

“An equity-busting markup of the Higher Education Act is making its way through Congress,” the Teachers said. Other education unions, including


challenges that must not be ignored by policymakers,” said the Auto Workers, whose union was just formally certified to represent 3,000 Teaching Assistants and Research Assistants at Columbia University.

“Budget cuts, skyrocketing tuition, increasing student loan debt, and a squeeze on academic workers by school administrations threaten the quality and accessibility of higher education, as well as the success of the academic research enterprise. A 4-year degree, associate’s degree, or vocational certificate is out of reach for many working families. Increased funding of education, including vocational education partnerships with community colleges as well as apprenticeship programs, is critical for our future.”

The committee’s Democrats were similarly caustic. All their amendments, including one to keep present loan programs and others to both enact the Dream Act and make the Dreamers eligiblequestionnaires were used for statistical analysis. The mean age of all the patients at the time of operation was 54.9 ± 9.3 years. The mean body mass index (BMI) was 25.4 ± 4.6 kg/m^2^.

This study enrolled 61 male and 284 female patients (17.7 vs 82.3%). Information on smoking status was available for 323 patients (93.6%), 86 (26.6%) of whom were smokers who smoked an average of 13.8 ± 7.1 cigarettes a day. Their smoking had begun at a mean age of 20.0 ± 9.6 years. These patients included 135 ex-smokers (41.8%) who had stopped smoking an average of 20.4 ± 11.0 years before the surgical procedure. Also included were 102 never-smokers (31.6%).

Table [1](#Tab1){ref-type="table"} presents a comparison of data relating to BMI, age, education level, and sun bed use among the smokers, ex-smokers, and never-smokers. The smokers underwent surgery 3.7 years earlier than the ex-smokers


485 F.Supp. 1077 (1978)
ASSOCIATION OF AMERICAN RAILROADS, Plaintiff,
v.
Brock ADAMS, Secretary of Transportation, Defendant.
Civ. A. No. 78-1184.
United States District Court, District of Columbia.
September 12, 1978.
*1078 *1079 *1080 Lee A. Monroe, Thomas Phemister, Washington, D. C., for plaintiff.
William Briggs, Asst. U. S. Atty., Washington, D. C., for defendant.

MEMORANDUM OPINION
JUNE L. GREEN, District Judge.
This action was initiated upon a motion for a temporary restraining order filed by plaintiff Association of American Railroads (hereinafter referred to as "AAR") challenging both the substantive and procedural legality of certain rear end train-marking regulations promulgated by the Federal Railroad Administration (hereinafter referred to as "FRA"). Plaintiff's motion for a temporary restraining order was denied, after argument, by the Court. Shortly thereafter, AAR's motion for a preliminary injunction was also denied, the Court finding, among otherhowever, opposed the tentative performance standard because it believed the standard to be too stringent. See comments of the AAR on Notice No. 1, FRA Docket No. RSRM-1 (December 17, 1976). With the exception of limited comments directed to the absence of an economic impact statement, AAR failed to exercise its right to comment on the subject matter of the FRA rulemaking.
At the public hearing of December 3, 1976, the AAR representative declined to participate though individual railroads presented oral testimony. The UTU representative argued for the use of lighted marking devices on all trains.
Written comments submitted to the FRA pointed out that the proposed performance standard, written in terms of straight track and clear weather conditions, would fail to assure safe railroad operation in those areas which


the words of the statute which it did not, or in the legislative history.
The Court finds the language of the statute clear and unambiguous and resort to the legislative history supports the Court's conclusion. A thorough search fails to reveal any evidence of legislative intent differing from the Court's conclusion that Section 431(g)(3) left the issue of freight car marking to the reasoned discretion of the Secretary. Rather, excerpts from the legislative history cited in the memoranda submitted by the parties consistently indicates legislative withdrawal from the subject of freight train marking.

Scope of Review
The rules now under judicial review were not required by Congress to be made on the record after agency hearing so compliance with the notice and comment provisions is all that is necessary in thisindicates why an environmental impact statement was not needed.
Krueger v. Morton, 176 U.S.App.D.C 233, 238, 539 F.2d 235, 240, 241 (D.C.Cir.1976). Though the facts in Krueger are inapplicable to the case at bar, the Court concludes that the action of the FRA is within the exception noted.
The rationale for the general rule regarding preparation of environmental impact statements was succinctly stated by the court in Scientists' Institute for Public Information, Inc. v. AEC, 156 U.S.App.D.C. 395, 481 F.2d 1079 (D.C.Cir.1973):
A statement of reasons will serve two functions. It will ensure that the agency had given adequate consideration to the problem and that it understood the statutory standard. In addition, it will provide a focal point for judicial review of the agency's decision, giving the court the benefit of


W-2, and they believed that any wages Mr.

Beecroft received from EP Management Services, Inc., were

included in a Form W-2 that he received from EP Production Co.2

The notice of deficiency states that "We have adjusted your gross

wages to agree with the amounts shown on Forms W-2."

       Petitioners' 1993 Form 1040 also reports a deduction for a

$24,661 loss from Mr. Beecroft's sole-proprietor business (the

Business).       The Business provided services on production design,

       2
       Petitioners received pay stubs for the respective checks
tendered to Mr. Beecroft from EP Production Services and EP
Management Services, Inc., and petitioners now concede that the
Form W-2 from EP Production Services did not list wagesCourt filed respondent's answer on

September 18, 1995.     Sec. 7430(c)(7)(A); Huffman v. Commissioner,

supra at 1148; see also Han v. Commissioner, T.C. Memo. 1993-386.

Ordinarily, we consider the reasonableness of each of these

positions separately.     Huffman v. Commissioner, supra at 1144-
                                - 12 -

1147.   In the instant setting, however, when these positions are

the same, we evaluate their reasonableness.

     Whether the Commissioner's position was substantially

justified turns on a finding of reasonableness, based on the

facts and circumstances of the case, as well as on any legal

precedents that may relate


negotiated an offer to purchase the flock at the appraised value
       derived by Mr. Udale. We believe that the government must uphold [its] promise
       and comply with its unilateral decisions to compensate [plaintiffs] pursuant to Mr.
       Udale’s appraisal . . . . [Plaintiffs’ counsel’s] letter of April 4, 2003, respectfully
       request[ed] copies of both the Udale appraisal and the Ann Seitzinger assumptions
       and conclusions. . . . [W]e feel the government has randomly re-written the rules
       to suit its agenda.

Id. Plaintiffs interpreted the USDA’s offer of $1,722,193.00 as a “minimum initial payment”must not weigh the evidence or make findings of fact.

                                                 8
See Anderson, 477 U.S. at 249 (“[A]t the summary judgment stage the judge’s function is not
himself to weigh the evidence and determine the truth of the matter but to determine whether
there is a genuine issue for trial.”); Contessa Food Prods., Inc. v. Conagra, Inc., 282 F.3d 1370,
1376 (Fed. Cir. 2002) (“On summary judgment, the question is not the ‘weight’ of the evidence,
but instead the presence of a genuine issue of


    The Court of Federal Claims possesses jurisdiction over takings claims against the United
States. See Murray v. United States, 817 F.2d 1580, 1583 (Fed. Cir. 1987) (“[T]he ‘just
compensation’ required by the Fifth Amendment has long been recognized to confer upon
property owners whose property has been taken for public use the right to recover money
damages from the government.”); Russell v. United States, 78 Fed. Cl. 281, 289 (2007) (“The
Takings and Just Compensation Clauses of the Fifth Amendment do constitute a money-
mandating source and claims under these clauses are within the jurisdiction of the court.”).

        The Supreme Court “has recognized that the government may ‘take’ private property by
either physical occupation or regulation.” Tuthill Ranch, Inc. v. United States, 381 F.3dpermanent and exclusive occupation by the government
that destroys the owner’s right to possession, use, and disposal of the property.” Boise Cascade
Corp., 296 F.3d at 1353; see also Loretto, 458 U.S. at 426 (“[A] permanent physical occupation
authorized by government is a taking . . . .”); Hendler, 952 F.2d at 1375 (“A physical occupation
of private property by the government which is adjudged to be of a permanent nature is a
taking . . . .”). A physical taking occurs when “government encroaches upon or occupies private
land for its own proposed use.” Palazzolo v. Rhode Island, 533 U.S. 606, 617 (2001); see also


the property . . . .” Keystone Bituminous Coal Ass’n v. DeBenedictis, 480 U.S.
470, 497 (1987). While the Supreme Court’s regulatory takings jurisprudence “cannot be
characterized as unified,” courts “aim[] to identify regulatory actions that are functionally
equivalent to the classic taking in which government directly appropriates private property or
ousts the owner from his domain.” Lingle, 544 U.S. at 539.

                              3. The Lucas “Antecedent Inquiry”

      A plaintiff must demonstrate title to a property right that has been purportedly taken.
Good v. United States, 39 Fed. Cl. 81, 84 (1997). In Lucas, the Supreme Court explained:

  initial offer of compensation to plaintiffs to be considerably below
market value. For that reason, plaintiffs explain, the initial offer of compensation was
immediately rejected. Ultimately, because the parties could not agree as to an amount to properly
compensate plaintiffs for the destruction of their flock and eggs, defendant retained an
independent appraiser to determine their value. Although defendant selected one of plaintiffs’
competitors, Mr. Richard Udale, plaintiffs agreed to be bound by the Udale appraisal so long as
no Cebe trade secret was revealed, plaintiffs received a copy of the appraisal for review, and they
confirmed the calculations made in the appraisal. In the event of erroneous calculations,
plaintiffs retained the right to challenge any mathematical errors in the Udale appraisal.

        Plaintiffs support their version of the facts


by USDA representatives, including . . . David F. Yogt,
[sic] that Udale would be fair and that both Plaintiffs and USDA would both be bound by the
special appraiser’s valuation”). Thus, plaintiffs are not entitled to summary judgment because of
the conflicting testimony regarding whether the USDA representative with whom they dealt
possessed the authority necessary to bind the government, or whether a ratifying official later
approved the parties’ alleged agreement. Rather, the issue concerning defendant’s
representative’s authority to bind the government raises genuine issues of material fact that must
be reserved for trial.

   C. Defendant’s Motion for Summary Judgment on Plaintiffs’ Fourth Cause of Action

        Defendant requests summary judgment in its favor on plaintiffs’ fourth cause of action,
which seeks compensation pursuant to the TakingsDr Gameshow #53

Comedians Bardia Salimi (I Am Not Your Uber) & Matt Barats (Reveries) join Jo & Manolo to play listener-created games with callers, including a special call from Ryan Rosenberg (Big Grande Teachers’ Lounge)!

Games played: Unique You, Movie Mash Up, and Dr. Manoshow

This episode is brought to you by DreamCorp LLC on Adult Swim and Green Chef (www.greenchef.us/gameshow).


horses, I sell them to you." "Did you, uh, bring some gold with you?" "No." "Silver?" "Just lead." "(LAUGHS) No, no." "You can't buy anything with lead." "Oh, well!" "(SIGHS)" "I guess I have to kill you and take your horses, too." "(SCREAMS)" "(HORSES NEIGHING)" "Let 'em go, mister." "We got what we came after." "Pretty good shooting, young fella." " You three all right?" " You bet we're all right." "American." "Uh-huh." "John, you go and meet your niece." "We'll take care of things around here." "Thanks, Henry." "Oh, uh..." " About that reception for Sallie." " Yeah?" "Bring this young fella along." "I will, and it's about time you two were introduced." "This is William Bonney." " Bonney?" " Came to work for me last month."way." "Get that mess off the street." "You know that gimp?" "I know of him." "His name's Dan Nodeen." "Half-crazy bounty hunter." "He gimps because of Billy the Kid." "Bonney put a bullet in him about two years back." "Mr. Nodeen, my name is Murphy." "You wouldn't be looking for a job?" "My job's collecting rewards." " Pat, can you read?" " Yup." "How far did you get in school?" "Got through the grades, then the war broke out." "I never got to school much." "Much?" "Hardly at all." "But I can read now and do my sums." "Mr. Tunstall's been teaching me." " He's a good man." " Yeah, seems like." "Pat, what do you hear about me?" "Billy, just to hear tell, it made my ears


it?" "Who's down there?" "BILLY: (WHISPERING) It's me, Mr. McSween." "Billy?" "What are you doing now, stealing from your friends?" "No, sir." "Not exactly." "We just need the loan of a little dynamite." " Dynamite?" " Yeah." "Billy, don't you think you've done enough already?" "No, sir." "But I'm going to." "(TENSE INSTRUMENTAL MUSIC)" "(HORSE NEIGHING OUTSIDE)" "NODEEN: (SOFTLY) Bonney." "Now, Billy, listen to me." "I've written a letter to the President." "There will be an investigation." "This whole thing is a travesty." "I promise you..." "Now I don't know what "travesty" means, but I made a promise, too." "Evans." "Evans!" " JESS:" "What do you want?" " Get up!" "Come on, get up!" "Alex, is everything all right?" "I heard..." "Billy." "Honey." "Honey, everything is all right."I'm tempted to push the old crones, Anna's trial begins at sundown and the last thing I want is ill will poisoning their opinion." She shifted her gaze sharply, boring into his own brown eyes. "However, I'm not inclined to leave Anna alone given recent events." The look on her face softened, worry shining through her frustration. "She was concerned enough about the ritual as it was; now, she's dealing with her brother's death, which she absolutely refuses to talk about-"

"I understand." He held up his hands in a placating gesture. "I'll keep her company while you deal with the Dosh Khaleen. I'm... sure she's still processing what happened with Hans." With a shrug, he gave her a lopsided smile. "I'll tell her stories of the Seven Kingdoms.


dreamy smiling coming to her lips as she looked away. After bearing witness to her fury the night before, it came as a bit of a shock to remember she was just a young woman with the power of a dragon running through her veins. "I didn't think about it, honestly. I was a bit... preoccupied at the time."

"Well, bring it up the next time you have the conversation." He crossed his arms with a smile. "She could've hunted him down, killed him much sooner than she did, but she made the decision not to do so. Her reasons may be a little different from yours, but I'd be willing to bet it will help her understand. There's a time and place to deal with those who haveand began washing her face, probably setting about her morning routine now that her mind was a bit clearer. "I noticed. I hope she didn't offend you last night; she was... justifiably rattled."

"Oh, no, I understand." He waved off her concerns with a nervous chuckle. "Besides, I have nothing to worry about. I've no intention to cause you any harm, Princess."

"Now we're back to being formal." She dryly pointed out, chuckling softly.

"Habit." He shrugged, trying to play off his momentary slip up as being born out of something other than fear. "You are my liege."

She paused at that, once again looking over at him. "Kristoff... what do you make of the Dothraki bloodriders? What's a true Seven Kingdom's view on the tradition?"

"I admire them," he replied truthfully, cautiously


long, she'd relied on excuses and little lies to make light of her brother's foolishness, but no longer.

Hans was gone. She'd taken his life to ensure the little one inside her would thrive. If anything, she gained more from the exchange than she lost, and the acknowledgement was bittersweet.

"You will have much better siblings," she said quietly, nodding to herself. "And you'll be a better elder to them than Hans ever was to me."

She took a deep breath, turning away from the ornate mirror- which she was pretty sure was a wedding gift, now that she thought on it- and glanced again at her weapons, laying beside Elsa's. She missed the weight of her arakh at her side, the rub of her bowstring against her chest, and thebite threatened to make her empty stomach revolt, obviously displeased with her first meal in a day or so being something so downright disgusting.

Still, she took another bite, reminding herself that this wasn't for the council's benefit. While it was partly for Elsa's, that wasn't the full extent of it, either. It simply came down to the fire she'd felt coursing through her veins the night Hans attempted to kill her, the dragon's blood in her body surging to the surface and reminding her of her true self. Truly, what dragon would balk at such a fine offering?

The taste didn't improve as she continued but her senses fell away one by one as she mechanically worked her way through the trial. Bite, tear, chew chew chew, swallow, and


for them all. The strongest, though, were the giddiness and joy evident in her voice. "No! Never!" She laughed, rolling on top of her beloved and glancing down, putting a hand on her wife's belly and imagining it swollen with a child born with their blood coursing through its veins, a near perfect twin for the child she was carrying. "Are you sure?"

Elsa easily matched her enthusiasm. "Certain."

There was a niggling doubt in the back of her mind, how both of them being pregnant at the same time could leave them vulnerable. It was quickly banished as she remembered what Kristoff had said earlier. So long as her conviction never faltered, she had nothing to fear; the blood of ancient dragons was now awakened within her. She'd triumphedthe trial court completely resolved a single claim for relief.

II.
Defendants next contend each request for restitution as to each consumer is a *1050 separate claim for purposes of certification under C.R.C.P. 54(b). Again, we disagree.
"In order for a judgment to be `final' with respect to a whole, single claim, that order must fix all damages stemming from that claim." Virdanco, Inc. v. MTS, Int'l, 791 P.2d 1236, 1238 (Colo.App.1990); see also Int'l Controls Corp. v. Vesco, 535 F.2d 742 (2d Cir.1976) (a default judgment that awarded damages in a sum certain was not a single claim where the order expressly allowed plaintiffs to prove additional damages); Alexander v. City of Colorado Springs, 655 P.2d 851 (Colo.App.1982)(C.R.C.P. 54(b) certification of permanent injunction improper where trial court reserved issue of


completely disposed of those employees' claims against the employer.
Here, the consumers are not named parties to a private action jointly prosecuting their individual claims. That a consumer could have commenced a private action for "actual damages sustained" does not make the State's equitable recovery of restitution for distribution to each consumer a separate claim in this case.
Nor is defendants' reliance on Ireland v. Wynkoop, 36 Colo.App. 205, 539 P.2d 1349 (1975), persuasive. There, some of the multiple transactions alleged in a single claim were dismissed on motion. In accepting an appeal from the dismissal, the division noted that "the appealed claims are factually distinct from the retained claims." Ireland, supra, 36 Colo.App. at 215, 539 P.2d at 1355. Here, while the trial court's phase I decision shows thatcustomers presents one claim or multiple claims for the purposes of directing final judgment pursuant to C.R.C.P. 54(b).
Whether, in determining if a case presents more than one claim for the purposes of C.R.C.P. 54(b), a court should base its decision on the substance of the action or on the manner in which a party presented the claims in the complaint.


arrangements for the breakup of ATT, the AMPS technology was distributed to local telcos.  The first commercial system opened in Chicago in October 1983.  A system designed by Motorola also operated in the Washington D.C./Baltimore area from summer 1982 and became a full public service later the following year.  Japan's first commercial radiotelephony service was launched by NTT in 1979.

The first fully automatic first generation cellular system was the Nordic Mobile Telephone (NMT) system, simultaneously launched in 1981 in Denmark, Finland, Norway and Sweden. NMT was the first mobile phone network featuring international roaming. The Swedish electrical engineer Östen Mäkitalo started to work on this vision in 1966, and is considered as the father of the NMT system and some also consider him the fatherwas estimated at 2.14 billion in 2005. The subscriber count reached 2.7 billion by end of 2006 according to Information, and 3.3 billion by November, 2007, thus reaching an equivalent of over half the planet's population. Around 80% of the world's population has access to mobile phone coverage, as of 2006. This figure is expected to increase to 90% by the year 2010.

In some  developing countries with little  "landline" telephone infrastructure, mobile phone use has quadrupled in the last decade. The rise of mobile phone technology in developing countries is often cited as an example of the leapfrog effect. Many remote regions in the third world went from having no telecommunications infrastructure to having satellite based communications systems. At present, Africa has the largest growth rate


along makes a right angle with the $xy$ plane. We end up with a point $q = (x_2, y_2, 0)$. Now we have the distance $d = \sqrt{(x_2 - x_1)^2 + (y_2 - y_1)^2}$ between $p_1$ and $q$.
Now since we projected orthogonally, we can make a right triangle with base the diagonal line connecting $p_1$ and $q$, and height going from $q$ to $p_2$. Then we can use the distance formula in the plane spanned by these two vectors just like before.
We have $D = \sqrt{\sqrt{(x_2 - x_1)^2 + (y_2 - y_1)^2}^2 + (z-0)^2} = \sqrt{(x_2 - x_1)^2 + (y_2 - y_1)^2 + z^2}$.
In general, if you do not want to assume that one point lies in the plane, the last term will become $(z_2 - z_1)^2$. Then- 15. Let o = p + 56. Which is bigger: o or k?
o
Let x(c) = 3*c - 175. Let q(k) = -2*k + 116. Let t(s) = 8*q(s) + 5*x(s). Let f be t(0). Is f greater than 53?
False
Suppose 3*c + 12 = 9*c. Let a be (c/4)/(7/((-343)/77)). Which is smaller: -1 or a?
-1
Let k be (0 - 2)/(21356/76). Are k and 1/2 equal?
False
Let w be (8/1)/(-5 + -9). Is w > 0.051?
False
Suppose 8*g - 5*g + 4*j = 25, -2*j - 4 = -4*g. Suppose -9*u + 2*u = g*u. Are u and -1/101 non-equal?
True
Suppose -g - 1 = 3*n, -5*g + 39 = 6*n - 2*n. Let m be (4 + (-6 - 2))/g. Which is smaller: m or -1?
-1
Let c be (-4 - -2)


lockout.

As for "they'll just lock you out again", there is no solution to that
problem. If you're using some funky backoff scheme, the same attacker keeps
you out by keeping the backoff high.

~~~
timf
If the lockout is based on IP, there's a very high chance I can hide this from
users because there's a very high chance that the nuisance is not coming from
the IP the user is logging in with.

If my app starts getting attacked with password guessing scripts every day
with correct account usernames, the users involved would need to be constantly
doing this email based reset scheme.

Personally, if this happened to me every time I logged in and there was an
alternative to the service, I would take my business elsewhere...

~~~
tptacek
I have zero faith in IP-based login reputation. Within the next couplewant one that will try to avoid the customer
needing to even know there was a problem if possible.

~~~
tptacek
"Reputation" is what the banks call this same solution, although it's just as
silly there.

My reasoning is, your solution is weak, and my solution isn't. Most user
accounts are rarely or never used. IP based backoff is a speed bump for a
coordinated attack against those accounts. Lockout completely stops it. And
lockout is _much easier to implement_ , which was my original point: people
are wasting too much time thinking about this problem, and coming up with
weird results.

~~~
timf
_"IP based backoff is a speed bump"_

Exactly what I want from it. Speed bumps solve problems. Locking your car
doors solves a problem. Neither guarantee anything but both have real effects
which make people's lives better.

That is, there can be


it easier to get around town efficiently. He paused for a few seconds, and checked that nobody was listening. "Well, I probably shouldn't tell you this but all locals know from experience that if you use a 2-trip ticket from either A&S or C&I, you have an almost 45% chance of ending up back where you started".
I had an enjoyable day touring the city. It was frustrating at times - it took me several attempts to get to get to A&S so I could visit the National Museum, but the people were friendly, the food (once I managed to get back to D&A) was delicious. And of course, I was happy because I knew exactly which pairs of stations were connected by the five tracks - thanks tosupport, protect, and provide cooling to the battery cells and facilitate placing the battery cells in electrical communication with each other and the associated electrical device.
It is desirable to support the battery cells and militate against damage thereto during a joining of the adjacent individual battery cells with each other or with an electrical connector. Further, it is desirable to produce a battery assembly, wherein an ease of manufacturing the battery assembly is maximized and a cost thereof is minimized.


Background {#Sec1}
==========

The low cost and high throughput of next generation sequencing has led to numerous reference genomes and resequenced genomes being published \[[@CR1]\]. However, almost all of these projects neglect the fact that diploid organisms contain two genome copies and consequently what is published is a composite of the two. This means that the relationship between alternate alleles at two or more linked loci is lost. Humans typically carry 250--300 loss of function variants most of which exist as heterozygotes \[[@CR2]\]. If two deleterious mutations are both heterozygous within the same gene and the deleterious alleles are both on the same chromosome then the individual will still have one non-affected copy of the gene and there may be no phenotypic consequence. However, if the individual is a compoundgap length for joining adjacent contigs into scaffolds was tested using threshold gap lengths from 100 to 2000 bp in increments of 100 bp for chromosome 12 (Fig. [4](#Fig4){ref-type="fig"}). The N50 scaffold length increased almost linearly with increasing threshold gap length, however the rate of increase in total length of all scaffolds from a library declined as gap length increased, particularly after about 600 bp. This is presumably a consequence of a decline in the length of gap relative to the length of contig and scaffolds as more scaffolds are joined. The effect on N50 scaffold size of using an absolute gap of 1000 bp or a gap of the mean + 3 standard deviations (μ + 3σ) ≈ 652 bp for each library and chromosome was compared. The N50 scaffold size for scaffolds assembled using gaps \< 1000 bp was 24.0 kb and


cells and a fosmid library. The unfragmented sperm cells generated the longest scaffolds as expected (N50 scaffold length of 80 kb with ContigMetrics and 413 kb with TargetCut). Given that the sperm were shipped from the USA to UK at ambient temperature (within a preservative buffer), it is also an indicator of the robustness of these cells.

The fosmid library generated scaffolds with N50 scaffold sizes that approximated to the expected insert size (\~40 kb) and these had the smallest variability in scaffold size (standard deviation) relative to mean scaffold length (Fig. [7](#Fig7){ref-type="fig"}). The N50 sizes of scaffolds found by ContigMetrics and TargetCut were similar. TargetCut was developed for fosmid samples and generated a mean and N50 scaffold length that only differed by 5 % (Table [4](#Tab4){ref-type="table"}), which also indicates that the length distribution wasof our protocol was to reduce the complexity and cost of the procedure in order to make it available to any laboratory with access to next generation sequencing. Our method only requires a haemocytometer and a microscope and we minimised the number of libraries to be sequenced and the amount of sequence obtained from each library. The amount of raw sequence data obtained for the Angus steer was in the same range (30 X genome coverage) as would commonly be used for a high quality consensus sequence. Making 30 libraries instead of just one adds to the cost of haploid sequencing and this is true of all methods proposed to date. Kaper et al. \[[@CR3]\] and Kuleshov et al. \[[@CR4]\] have also obtained haploid sequences by limiting dilution.


At \> 0.1 genome equivalents per library the main determinants of cost were the target depth of read coverage over scaffolds and the scaffold coverage of the genome. Read coverage of scaffolds has to be sufficiently high to detect a large proportion of heterozygotes within a scaffold to mark it for removal. If read coverage is uniform then 4 X read coverage of scaffolds would detect 61 % of heterozygotes which should be sufficient to detect most diploid scaffolds (Supplementary data CostCalculator.xls). However genome amplification with phi29 is very skewed so scaffold coverage would need to be correspondingly increased; with long PCR \[[@CR4]\] or MALBAC \[[@CR19]\] 4 X coverage should be adequate. With very high genome dilutions then detection of heterozygotes becomes unnecessary and coverage can be correspondingly lower, Kuleshov etgenomeScaffold coverageMean scaffold length (bp)246810121416182010,0002545566367727678808120,0004267808791949596979730,00049779095969899999910050,000568695989910010010010010070,00062899799100100100100100100

SIH uses the SNP data from all scaffolds to form a single pair of SNP haplotypes from all overlapping scaffolds. The SNP haplotypes are expected to be larger than the scaffolds and this was found, although mean SNP haplotype lengths were only marginally longer than mean scaffold lengths for the EAZ cells, presumably because these cells were drawn from a population not a single animal and therefore overlapping scaffolds would not necessarily be consistent. Although N50 lengths for SNP haplotypes were large (97--190 kb) for the Angus steer there was a substantial loss of data since genome coverage fell from \~ 91 % for the informative scaffolds to \~66 % for the SNP haplotypes. The ability of any method to reconstruct whole genome haplotypes will ultimately be determined by


short read sequencing.Fig. 8Sample processing workflow. Lymphocytes are prepared from whole blood and are then diluted with the use of a haemocytometer to count the concentration of cells at each dilution. Aliquots containing single cells were taken and lysed and six aliquots were taken from each single cell sample and independently amplified using Genomiphi

Samples {#Sec15}
-------

Samples were collected from two sets of animals. First, from a single Angus steer (number 72711) from the University of Missouri research farm and a semen sample from a US registered Angus bull (Lab Id 1736). Second, from 18 East African Zebu (EAZ) cattle sampled in Busia district near Lake Victoria in Western Kenya in January and February of 2012. Finally, a fosmid library was prepared from EAZ cow 121-147 collected from Busia atThe effect of cholesterol on the intrinsic rate of lipid flip-flop as measured by sum-frequency vibrational spectroscopy.
Cholesterol is a major constituent of biological membranes in mammalian cells. Experiments have shown that cholesterol influences the physical properties of the plasma membrane, such as lateral diffusion and phase equilibrium. In addition to controlling the 2-dimensional phase behaviour and mobility of lipids in membranes, cholesterol has also been implicated in the transbilayer diffusion of lipids across the bilayer. Sum-frequency vibrational spectroscopy (SFVS) is used to measure the intrinsic rate of lipid flip-flop for 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) in the presence of cholesterol using planar supported lipid bilayer (PSLB) model membranes. Asymmetric PSLBs were prepared using the Langmuir-Blodgett (LB) method by placing a perdeuterated lipid analogue in one leaflet of the PSLB. SFVS was


T cells, that could recognize and destroy the tumor.

Currently, despite the remarkable success also in the metastatic setting of several approved monoclonal antibodies, such as anti-CTLA4 (Ipilimumab, Tremelimumab) and anti-PD1/PD-L1 (Nivolumab, Pembrolizumab, Atezolizumab, Avelumab, Durvalumab), a good percentage of patients do not respond to treatment and may develop different pattern of toxicities, known as immune related adverse events (irAE).

Various biomarkers (e.g. PD-L1 expression, intratumoral immune infiltrate, mutational burden etc\...) have been supposed to reflect the ICIs pharmacodynamics and to predict ICIs efficacy and/or toxicity, but their relevance is still unclear. \[[@R3]\].

It was shown that the sex, defined by the differential organization of chromosomes, reproductive organs, and sex steroid levels, represents an important biological variable that influences innate and adaptive immunity. The sex influence on the immune system isPhase II and Phase III Clinical Trials published up to June 2017 in which immunotherapy was tested (anti-CTLA-4, anti-PD-1 and anti-PD-L1) in patients affected by solid cancers. Of these studies, 17 were Phase III Trials subdivided as following: 8 on melanoma, 6 on NSCLC, 1 on RCC, 1 on head and neck tumors and 1 on urothelial carcinoma. \[[@R13]-[@R30]\] Nineteen were Phase II Trials: 10 on melanoma, 5 on NSCLC, 1 on RCC and 3 on urothelial cancer. \[[@R31]-[@R50]\] From this selection, 2 studies were excluded because results were published only as abstracts, 21 because the subgroup analysis differentiated by sex was not reported and 2 because the patients in the control arm received ICIs. (Figure [1](#F1){ref-type="fig"}).

![Consort diagram for trial selection](oncotarget-08-99336-g001){#F1}

In the final statistical analysis for OS 9


![Forest Plot for PFS with anti-PD-1](oncotarget-08-99336-g004){#F4}

DISCUSSION {#s3}
==========

Males and females differ in the immune response to infections and vaccines and in the predisposition to develop autoimmune diseases. \[[@R4]\].

The observation that not only hormonal factors but also genetic, and environmental mediators are involved in sex-based immunological differences lead to hypothesize that different outcome during immunotherapy could depend on the patient's sex.

TheThe star filmed a moment that was deemed too confusing by test audiences.

When audiences walked into Avengers: Endgame, one member of the cast was nowhere to be found on the big screen: Katherine Langford. In October, news broke that the 13 Reasons Why star had filmed scenes for the fourth Avengers film, and speculation swirled about who she could be playing. Hawkeye protege Katy Bishop? A grown version of Ant-Man's daughter Cassie? Death herself? It turns out, she had been cast as an adult version of Morgan Stark, daughter of Tony Stark (Robert Downey Jr.). Endgame directors Joe and Anthony Russo revealed on MTV's Happy Sad Confused podcast that they filmed the scene with Langford that would have mirrored an Avengers: Infinity War scene in which Thanos (Josh


Q:

Why can integer type int64_t not hold this legal value?

I'm trying to write a test case for some corner case. For input of type int64_t, the following line won't compile:
int64_t a = -9223372036854775808LL;

The error/warning is:
error: integer constant is so large that it is unsigned [-Werror]

I thought the number was out of range, so I tried:
std::cout << std::numeric_limits<int64_t>::min() << std::endl;

It outputs exactly the same number!!! So the constant is within the range.
How can I fix this error?

A:

You may write
int64_t a = -1 - 9223372036854775807LL;

The problem is that the - is not part of the literal, it is unary minus.  So the compiler first sees 9223372036854775808LL (out of range for signed int64_t) and then finds the negative of this.
By applying binary minus, we can use two literals which arethrough various paths in the photocopy device. For example, the sheet is transported via a specified path to an area in which an image is reproduced on the paper. Thereafter, the sheet is transported via additional paths to a recovery bin from which the sheet can be retrieved.
Monitoring the position of each sheet as it passes through the various paths is integral to the operation of the photocopier. Various conventional sensors are currently used to detect the object's position in a conventional photocopier. For example, one conventional device for detecting the position of a paper sheet includes a light source and light sensor arrangement. This device may include a light emitting diode (LED) and a photodiode pair, wherein the light source emitted from the LED is eclipsed as


do not act as additional source for entanglement. The distinct features of the one-way model also allow us to cast the introductory question into a much more concise form, viz. *what are the essential properties of the cluster state that make it a universal resource?* In this letter we will investigate this question. The main objectives of our investigation are (i) to understand which states, other than the cluster states, are universal resources for MQC and (ii) to gain insight in the role of entanglement in this matter. It is believed that the high degree of entanglement in the (2D and 3D) cluster states plays an important role in the universality of these states, but the explicit entanglement features accounting for this have not been identified yet. Fore}(|\psi\rangle)$, where the latter is the bipartite entanglement entropy of $|\psi\rangle$ with respect to the bipartition $(A_{T}^e, B_{T}^e)$. The entanglement width of $|\psi\rangle$ is now defined as E\_(|):= \_T \_T(|)=\_T \_[eT]{} E\_[A\_[T]{}\^ e]{}(|),where the minimization is taken over all subcubic trees $T$ with $m$ labeled leaves.

An exact evaluation of entanglement width in a generic state is likely to be a hard problem, given the min–max problem in the definition. However, the strength of this measure lies in its connection to the graph–theoretical measure *rank width* ${\rm rwd}(G)$ [@Oum], where good upper and lower bounds – that are sufficient for our purpose – are known. The entanglement width of a graph state coincides with the rank width of the underlying graph, which follows from the equivalence of the cut–rank [@Oum] of an


prove universality by explicitly constructing LOCC protocols that yield the 2D cluster state (top–down approach). The proofs are based on successive applications of simple rules how to update a graph when applying certain local operations on the corresponding graph state [@He06], where we only use local complementation (inversion of neighborhood graph) and vertex deletion, corresponding to $\sigma_y$- and $\sigma_z$-measurements, respectively. Note that the square 2D lattice, together with the hexagonal and triangular lattices are the only possibilities to obtain a regular tiling of the 2D plane. Furthermore, the Kagome lattice is an example of a uniform semiregular 2D tiling with 2 basic tiles (the triangle and the hexagon). The hexagonal lattice has vertex degree 3, which leads to an increased robustness against local noise as compared to thewith $\Lambda={\mathop{\rm diag}\nolimits}(1,\lambda)$ and $\lambda <1$, i.e. these states can be probabilistically obtained from the 2D cluster state by applying local filtering operations. The inverse transformation is also possible, however the success probability is exponentially small. Nevertheless, a single copy of a state in this class is weakly universal when $\lambda$ lies above a certain threshold. To see this, note that one can deterministically transform a state $|\psi_{k\times k}\rangle $ by means of LOCC into a graph state corresponding to a 2D lattice with defects, by applying local 2–outcome measurements described by $\{\Lambda^{-1}={\mathop{\rm diag}\nolimits}(\lambda,1),\ \overline{\Lambda^{-1}}={\mathop{\rm diag}\nolimits}(\sqrt{1-\lambda^2},0)\}$ at each qubit. One finds that the defect probability $p_{\mbox{\scriptsize def}}=(1-\lambda^2)/(1+\lambda^2)$ is independent of the system size, and for $\lambda > \lambda_0 \approx 0.98$ one can indeed show that the resulting resource


ordered the invasion of Cambodia. The Kent State shootings followed a few days later. The spotlight shifted abruptly away from the environment.

But the environment returned to national prominence in the fall of 1970. The Earth Day organizers jumped into the Congressional elections, seeking to defeat a “Dirty Dozen” of incumbent Congressmen. The targets were selected because they had abysmal environmental records, but also because they were in tight races and were from districts with a major environmental issue that voters cared about.

The first of the seven Congressmen we took out that fall was George Fallon from Baltimore. Representative Fallon was chairman of the House Public Works Committee, the “pork” committee, and a powerful opponent of mass transit. Politicians of all stripes took notice: If Fallon was vulnerable, everyone     \end{array}
                                                        \right.$\
and we denote by $\mathcal{P}$ the set of ponderation functions. We point here if $|A^c|= \infty $, $\chi_A $ does not belong to $\mathcal{P}$. It has been proved in [@AZ] that the set $\mathcal{R}  =\Big{\{}\sum_{\mbox{\small {finite}}}\chi_{A_i}\varphi_i : A_i\subset \mathbb{N}^n,
 \, \varphi_i\in \mathcal{P}\Big{\}}$ is a commutative ring with the usual operations “$+$” and “$\cdot$”, called the ring of ponderation functions. Moreover an ideal of $\mathcal{R}$, is minimal


2352?
2
What is the thousands digit of 3751?
3
What is the hundreds digit of 309?
3
What is the ten thousands digit of 27961?
2
What is the ten thousands digit of 21401?
2
What is the hundreds digit of 64674?
6
What is the hundreds digit of 464?
4
What is the hundreds digit of 179?
1
What is the units digit of 16212?
2
What is the tens digit of 30549?
4
What is the hundreds digit of 3158?
1
What is the tens digit of 8918?
1
What is the thousands digit of 1198?
1
What is the thousands digit of 5334?
5
What is the thousands digit of 17406?
7
What is the units digit of 653?
3
What is the tens digit of 139751?
5
What is the thousands digit of 22555?
2
What is the tens digit of 1093?
9
What is the ten thousands digit of 18141?
1
What is the tens digit of 1004?
0
What is the units digitcatephoresis typically created by low frequency A.C. operation or D.C. operation of such a lamp.
It is a further object of the present invention to provide means to reduce the sodium ion migration typically experienced for a metal halide lamp.
It is a further object of the present invention to reduce the sodium ion migration caused by metallic mounting members emitting photoelectrons which contribute to the loss of the sodium ions of the metal halide lamp.
It is still a further object of the present invention to provide containment means so as to reduce the possible detrimental effects that may occur during the unlikely event of the rupturing of the metal halide lamp operated at a relatively high pressure.


whereabouts?" " Where am I?" " "Where am I?" Where do you think you are?" " What's that?" " What's that?" " Where's my stuff?" " Where's my stuff, eh?" "Whose is this?" "What's going on?" "Mister Pipari!" "Your suitcase." "Your suitcase." "Later?" "Okay." "They've confiscated my suitcase." "What's going on?" "What am I going to do?" "Me?" "Hey, you!" "My money, twenty euros!" "Nationality?" "Where you come from?" "Spitting gibberish out of his mouth..." "Do you speak English?" "Look, if you don't start to speak, we have to arrest you." "Capisce?" "He's going to put you in prison." "Joyless, joyless jail." "Joyless jail, joyless jail." "Albania?" "Bosnia-Herzegovina?" "Macedonia?" "Croatia?" "Serbia-Montenegro?" "Albania, albino." "Herzegovina, govina-ment." "Child of Finland, never leave your fatherland Croatia..." "Tell him where you comecouldn't leave you here alone." "All our luggage is in Florence and I left my cellphone there - and I don't remember Laura's cellphone number." "Well, let's sleep overnight - book new flights in the morning and call Laura." "There's nothing to worry about." " Is everything all right?" " Everything's all right, I promise." "You're sure?" "No, I've never been to the harbor, really." "The police came for you at the harbor, Johannes." "You climbed into a crane." "What was in the crane?" "They keep sending me..." "They send me keys in letters." "They said they were keys to the attic." "Mustn't let..." " Who?" " The house manager said - no one is to go to the attic because of the asbestos men." "The asbestos goes


" Hi." "Is John okay?" " Piipari." " Piipari..." "John, is John okay?" " John okay." " All right." "Ciao." "Ciao." "Sorry... when?" "Maybe three days ago." "Do you want to buy it?" " No." " Okay." " Yes, I do." " Well, great." "Okay, thank you." "Oh, Finnish." "Finland, yes yes!" "You've been banging in bed!" "Who was the partner?" "Where's the passport?" "With no rubber." "Pox and aids." "Aids will rot your brains!" "Who was it?" "Bang the door!" "Bang it!" "Your brain will rot." "Well it's your brain, no business of mine." "You stay here, but get your goddamn passport so I can leave!" " I'm very sorry, it's late..." " No, it's okay." "It's okay, okay..." "I'm very sorry, it's okay." "We met inin a week." "I made you a little something, had nothing else to do..." "It's nothing much, but..." "In case you have any use for it..." "What?" "Have you been doing arts and crafts?" "The hell I have!" "Just some junk, a knick-knack." "Bought it from a street vendor." "This is for you." "Happy the Chap, are you sure?" "Thank you." " So..." " Hope you'll be fine - and remember: our doors are always open for you." "I'll be fine, but I don't know about a drunk moving onto a wine farm." " Drunk." " Crazy." "Crazy drunk." "Could it be...?" " What?" " Malpractice." "You remember!" "Do you remember?" "You remember!" "One, two, three, go!" "It started tilting so badly - that people were afraid it


Caitlin Bodfish, Italian Insider, July 31, 2018

An Italian merchant vessel has taken 108 migrants back to Libya, an incident criticised by the UNHCR yet disputed by Italy’s Interior Minister Matteo Salvini, coastal police reported on Tuesday.

An Italian boat has never before brought migrants back to Libya after being rescued in the Mediterranean, but on Monday everything changed. The vessel, having saved 108 people on board a raft then accompanied them to the port at Tripoli.

According to the Repubblica newspaper, the decision was taken after the Coastal Guard’s control centre in Rome ordered the ship, a vessel which supports an oil platform, to work with the Libyan navy.

Matteo Salvini, Italy’s Interior Minister, discredited the information as “false” in a post on Facebook. Meanwhile, the UN Refugee Agency UNHER has/**
 * Copyright (c) Facebook, Inc. and its affiliates.
 *
 * This source code is licensed under the MIT license found in the
 * LICENSE file in the root directory of this source tree.
 */

import {flatten, uniqBy, difference, groupBy} from 'lodash';
import {
  PluginContext,
  RedirectMetadata,
  PluginOptions,
  RedirectOption,
} from './types';
import {
  createFromExtensionsRedirects,
  createToExtensionsRedirects,
} from './extensionRedirects';
import {validateRedirect} from './redirectValidation';

import chalk from 'chalk';

export default function collectRedirects(
  pluginContext: PluginContext,
): RedirectMetadata[] {
  const redirects = doCollectRedirects(pluginContext);
  validateCollectedRedirects(redirects, pluginContext);
  return filterUnwantedRedirects(redirects, pluginContext);
}

function validateCollectedRedirects(
  redirects: RedirectMetadata[],
  pluginContext: PluginContext,
) {
  const redirectValidationErrors: string[] = redirects
    .map((redirect) => {
      try {
        validateRedirect(redirect);
        return


they, 365 days a year." "So stop snivelling and go out and sing." "Sing for your man and for those 300 men!" "Make yer clothes vanish!" "Try sitting' on it!" "Bye Pratte, 'n thanks." "Nothin' to it." "It's gonna work." "Thanks." "'Night, Miss." "Sylvie Nantel!" "I want to dedicate this song to number 7195." "To me he's Pierre Boyer in deadlock." "Only one law" "A single desire" "Ever nearer to you" "Whom I can't resist" "I feel your shadow against my skin" "I feel your breath" "On my back" "And rising in me" "A deepening quiver" "It's coming over me" "The feeling of you" "Closer... closer" "Don't hesitate" "Between my thighs" "More, oh more" "Deep inside me" "Deep inside you" "Come my love" "In my arms" "I'm lookingSo much for Green Tech being so much better than anyone in the Class A’s, and BG had trouble with a less than average SGF. As I said before, Don’t count out Johnstown, as they have The Big kid Vdoviak in the middle and he can shoot. So I guess BH’s won’t have to wonder if they can upset GF now, and AP’s fan who mentioned earlier in the season that AP could easily beat anyone in the foothills, they can also forget about the sectionals. I watched the AP, Qby game, and it was a great high school game. AP tied it with about 6 seconds to go, but while celebrating they allowed QBY to race down court and score the winning basket as Bethel was all


to 20) between groups or in return to eating (P = 0.48, 95% CI -92.0 to 113.5), with most cats eating within 1 h of surgery (butorphanol, 79%; buprenorphine, 83%). There were no significant differences in analgesia or recovery between butorphanol and buprenorphine treatment groups as part of a multimodal injectable anesthetic protocol. Butorphanol is associated with superior depth of anesthesia, facilitating injectable anesthesia.optimisation as well.
public static class Sizes
{
    public static readonly int Bare = 0;
    public static readonly int VariableByte = 65536;
}

You can use them the same way but now as Sizes.Bare is an integer with value 0 you can use it in an addition.


it took me about 3 1/2 hours overall to build at a cost of about $51.00. So far. The main unit is done but needs painting, upper light brackets, and lights. I have a couple of 2 bulb shop lights but I'd like to get two 4 bulb lights. Oh well one thing at a time. I will start painting tonight and hopefully finish it off tomorrow night.

I can get 4 plats on the bottom and 4 on the top. It's made from mostly junk lumber at the local home improvement store. The tops are 5/8" particle board. Reason for the paint as water and particle board do not mix. I have a separate page showing the complete process with the link to the right. I did havethe right size for 4 plats. I think I will try to design and build a 2-3 level grow stand.

It was a beautiful day to say the least. 69 degrees late this afternoon. I can really get used to days like today. Hope to have some ideas for you tomorrow.

I have most of these seeds already and just ordered some from Territorial Seed Company. Territorial Seed Company also has a garden planner that is useful. Click here to check it out. I will more than likely get the herb seeds from my local store. I also purchased an 18 gallon tote to try my hand at a SWC. I am now on the lookout for some big, round, wooden containers. I want to use them for my herbs


A few hours after scoring the first pole position of his Porsche GT3 Cup Challenge USA by Yokohama career, 17-year-old Riley Dickinson went on to take his first career victory in the penultimate round of the 2019 season.

Dickinson led from start to finish but had to hold off Roman De Angelis in the No. 79 Kelly-Moss Road and Race Porsche throughout.

The youngster from New Braunfels, Texas, beat De Angelis to the line by 1.060 seconds.

The runner-up result for De Angelis was more than enough to give the Canadian the 2019 GT3 Cup Challenge USA championship in the Platinum Cup class for Porsche 911 GT3 Cup cars built between 2017 and 2019.

With one race still to come Friday morning, De Angelis holds an insurmountable, 62-point lead over No. 7the No. 27 NGT Motorsport Porsche. Carazo also has finished on the podium in all 15 races this season and now leads Rob Ferriol by 50 points, 511-461.

Ferriol finished second in Gold Cup the No. 5 Moorespeed Porsche ahead of Curt Swearingin, who finished third in the No. 17 ACI Motorsports Porsche.

The 2019 Porsche GT3 Cup Challenge USA by Yokohama season draws to a close with one more 45-minute race beginning at 10:10 a.m. ET Friday.

RESULTS: Race 1


t be j(-18). Is 54 a factor of t - (-5)/((-20)/(-4364))?
False
Suppose 6*u - 18 = 0, -8*i + 3*u = -10*i + 10809. Is i a multiple of 15?
True
Let a = 83 + -80. Suppose -y = -a*z - 141, z + 162 - 27 = y. Is y a multiple of 12?
True
Let m(q) = -6*q + 3. Let c be -2*2*(-3 - (-22)/8). Let j be m(c). Is 28 a factor of ((-4)/1)/(j/(-21)*-1)?
True
Suppose 0 = -32*c + 45*c - 9867. Let z = c - 486. Is z a multiple of 21?
True
Let z = -678 + 440. Let p = -100 - z. Is 6 a factor of p?
True
Is 118 a factor of (-25 - -8) + (15975 - 28)?
True
Suppose -1 = -h + 2*c, -3*h +of v?
True
Let k(x) = -x**3 + 54*x**2 - 122*x - 154. Does 78 divide k(47)?
False
Is 0*(-20)/(-380) + (0 - -1321) a multiple of 9?
False
Let g be (-28 - -34) + (-4 - -1). Suppose -170 = -w + g*u + 456, -15 = -3*u. Does 9 divide w?
False
Is 9 a factor of (-78)/156 - 3350/(-4)?
True
Let l(n) be the first derivative of n**5/20 - 3*n**4/4 - 13*n**3/6 - 33*n**2/2 + 8*n - 31. Let k(x) be the first derivative of l(x). Is k(11) a multiple of 3?
True
Suppose 0 = 4*y - 4*o - 24, 3*y - 9*o + 12*o = 30. Suppose y*i = 98 + 102. Is i a multiple of 8?
False
Let g be 931/(-3) - -2*1/6. Let v = g + 645. Suppose -4*l - v =


m. Round l to zero decimal places.
-8
Let a = 111 + -101. Let b be (-10)/4 - 95/a. Let z be 302/(-18) - b/(-54). Round z to the nearest integer.
-17
Suppose -4*y + 31024 = -119316. Let l = y + -97685. What is l rounded to the nearest 10000?
-60000
Let v = -2.7 + -2.4. Let l = -2.191969 - -7.291914. Let b = v + l. What is b rounded to five decimal places?
-0.00006
Let j = -35.742 + 35. Let u = 8023 + -8024.11. Let v = j - u. Round v to two dps.
0.37
Let s be 1/(1/(-5) - 2629890/(-13149575)). Let p = s + -361017. What is p rounded to the nearest 10000?
-890000
Let i(q) = 22*q**3 + q**2 + 30*q - 125. Let y be i(15).HIT THE JURY'S EARS TODAY IN DAY 9 OF THE LEVI CHAVEZ MURDER TRIAL. CHAVEZ'S WIFE, TERA, WAS SEEING ANOTHER A-P-D OFFICER. BUT HE BROKE IT OFF WITH HER. AND A FEW WEEKS LATER... SHE WAS FOUND DEAD. ACTION 7 NEWS REPORTER ANNA VELASQUEZ IS LIVE WITH DETAILS. ANNA TANYA A-P-D OFFICER NICK WHEELER SAYS TERA FELL IN LOVE WITH HIM. BUT HE DIDN'T, AND REFUSED TO LEAVE HIS WIFE SAMANTHA. HE INSISTED... SHE NEVER INDICATED SHE WANTED TO HURT HERSELF. NICK WHEELER TESTIFIED HE AND TERA CHAVEZ'S AFFAIR BEGAN IN AUGUST OF 2007 HE FIRST MET HER A COUPLE MONTHS BEFORE THAT... WHEN HIS WIFE TOOK HIM TO STYLE AMERICA SO TERA COULD CUT HIS HAIR. 2/2:23 one day i received a text message from a number


patients, CRCs result mainly from external causes including long-time exposure to carcinogenic agents, decreased immunity, and communication of genetic variations. Carcinogenetic agents in the local environment accumulate more in the distal colorectum than in the proximal colon. Tumor microenvironments were also different according to tumor location, with more peritumor lymphocytes and more tumor-infiltrating lymphocytes in proximal tumors than in distal ones\[[@pone.0167540.ref039]\]. All these factors may contribute to the superior outcomes in older patients with RCC. In fact, among patients older than 50 years, outcomes improved with age for RCC compared with distal CRC. In summary, RCC patients had better outcomes than those with distal CRC in several subgroups including stage II disease, patients aged ˃70 years and mucinous adenocarcinoma. Tumor heterogeneity and different carcinogenesis may make contributions.

In twoD&D Xanathar's Guide to Everything (5E)

Wizards of the Coast

This product is part of a bundle. Complete the set and save on all bundled products you don't already own and all future additions to the bundle.

D&D Essentials Bundle

Dungeons & Dragons: Xanathar's Guide to Everything

Explore a wealth of new rules options for both players and Dungeon Masters in this supplement for the world’s greatest roleplaying game.

The beholder Xanathar—Waterdeep’s most infamous crime lord—is known to hoard information on friend and foe alike. The beholder catalogs lore about adventurers and ponders methods to thwart them. Its twisted mind imagines that it can eventually record everything!

Xanathar's Guide to Everything is the first major expansion for fifth edition Dungeons & Dragons, offering new rules and story options:

Over twenty-five new subclasses for the character classes


your darling Naija? Happy?

This4Dfools

This brain you refer to as dull is by far better than yours, just read your own response. And what has dull or no dull brain have to do with asking for better leadership in ones country. Just when you think you are smart you show your ignorance; haven’t you come across the saying “book smart”?, yes you may be book smart and work for one of the fortune 500, well, guess what you are a mere tool in the hands of the owners, chew on that smarty! that’s the slavery part of it, too deep for you?. There are farmers in your village who would die first than swap place to obtain your decorated slavery you are so proud of…. slave away your lifebut spare the living your confused way of life. Ji sike!

Stauber

I knew it! Folks like you are grossly incorrigible and would prefer to hide in ignorance perpetually. I will do my best to make you think a little bit within this window of opportunity that this news article presented. “IF” is a conditional statement which means when a certain situation is assumed to exist, something is considered and when a different situation is assumed to exist instead, then another thing is considered (this is the else part). That’s as layman as possible. So when I said “if Awul’s brain was dull”, it means, when we assume that his brain was dull (doesn’t mean it was, just an assumption) then he might be limited from excelling in the US


for… Thank you guys

Adesanwo Qurccim

Good, you should be a hero by now

abiodun johnson

Why are you repudiating the poster, no matter how smart you are, what jobs do most Nigerians or any foreigner do when they first arrived in the US? Factory work and other back breaking jobs, unless you were from a wealthy family that can sponsor your education and living fees, how else do you survive? Isn’t a maid a better profession in the united states than a dish washer, or a factory worker or even a taxi driver that most Nigerians do for a living while going to school in the US? Be objective pal! Be real, If Nigeria’s leaders can create jobs internally for Nigerians, we won’t need to enslave ourselves to foreign countries fora year with handouts and good study condition excluded. One thing a lot of guys here refuse to understand is that the Government of the so called our Nigeria has made it known over decades that every Nigerian is “OYO”. Back in the days where job is secured as soon as you become a graduate.. did your fathers not tell you that?.. you don’t know anyone at the top of any institution to secure a job, then FORGET IT!.

omo ola

You be correct guy.. TELL THEM!!!

This4Dfools

Leave them alone let go and see the wonders.

Alex

You chose to work as a maid probably because you’re dumb and don’t know any better. I came here 6 years ago and today I have a degree in Electrical engineering and Physics and i had


of immigration to the United States. For fiscal year 2015, 50,000 diversity visas (DVs) will be available. There is no cost to register for the DV Program.

Applicants who are selected in the lottery (“selectees”) must meet simple, but strict, eligibility requirements in order to qualify for a diversity visa. Selectees are chosen through a randomized computer drawing. Diversity visas are distributed among six geographic regions and no single country may receive more than seven percent of the available DVs in any one year.

For DV-2015, natives of the following countries are not eligible to apply, because more than 50,000 natives of these countries immigrated to the United States in the previous five years:

Changes in eligibility this year: For DV-2015, natives of Nigeria are no longer eligible.

dd

If you go thereintroduced most of quota system used now to benefit the north are championing federal character but have more states than the south? so the north have more NASS members than south, yet the same North do not want 50 % resource control from the people that have the resources to develop in their own pace…. how can senate vote for child marriage quoting Islamic religion which Koran super-cedes and neglect the neutrality of the secularist of Nigeria when Nigerian was part of signatory for abolishing of child marriage in the world? the same senate did not look at the human rights violations to the rights of the same-sex marriage but voted for child marriage what a hypocritical country called Nigeria..most of our problems constitutionally are from the ethnicity


50, 000 visas for Nigeria in the last five years.

tiji

Thank you for your post and everything you said is right on the money. People should read US lottery rules before they comment. They have rules in this country and they obey them and if you do not like their rules, go to other countries.

Mayowa

and UK said before they can give Nigerian their visa, we need to pay a bond fee of #3000 pounds ( about N765,000). what is the way forward Nigeria Govt.

Guess what?

Yes they are right. They just need to find ways to getting our leaders to wake up against corruption and violent islamization. Their solder was beheaded on the open street in London. UK would have been stupid not to to take the right steps toIN A DUBIOUS AND FETISH WAY. BUT WE THAT ARE STRUGGLE TO MAKE A LEAVING WE ALWAYS APPRECIATE USA ANDO THER COUNTRIES THAT THING ARE GOING THE WAY IT SUPPOSED TO GO.GOD BLESS YOU

dozil

U.S or Naija………lets keep moving ahead cos we can’t stop what is meant to be ,tell God whats app

seemwell

@atanda, dont glame those who regard lottery as slavery. If our leaders do the right thing, nobody will be looking for greener pastures. A country like UAE will never allow it’s citizen to travel to USA bcos all what he needed are provided by his government.

okey

you guys dint even understand what was written and that is why we are confused in this country. the reason why Nigeria was banned from visa lottery is because we have reached


ibos asked for it

Hans

See? You’re a worse bigot than the whiteman you’re so eager to criticise. Sorry, am not Ibo. But why do you carry so much tribal hatred?

ajax

Then you dont need to cry. Let the ibos complain. Have fun!

one of you

I have never heard so much abuse, can you guys not make your point without so much hostility!…scarry !!!

Hans

You are the real slave, Ton. Your masters are in Abuja and they are very mean!

kogberegbe

u must have won the lottery= cause as a New York social security office administator ,u do not have the criteria to qualify for the above mentioned= Not even half Us citizens qualify for thos e- for their are parameters and yadsticks for qualification except if you had beaten our beatable system with oluwoleUS department of state in-charge of the electronic diversify visa that for example those of of from Africa (Kenya) who are will to play the 2016 dv lottery but living for example in china which has been exempted from the 2016 dv lottery,what are we going to do.


potential landlord or employer. The cost and lead times to lift a freeze vary, so it’s best to check with the credit reporting company in advance.

Although a credit freeze is an effective tool, it won’t prevent a thief from making charges to your existing accounts. You still need to monitor all bank, credit card and insurance statements for fraudulent transactions.I hope it’s clear that when people talk about “creating inflation” as a monetary policy, they aren’t talking about a 0.1% per annum rise in the CPI over the next 10 years. If that were the definition, then almost all policymakers, even Richard Fisher, would be inflationists. A more reasonable definition of a policy of “inflation” would be “higher than normal,” or “higher than the Fed’s 2% target.”

I’m going to provide some estimates of what I think would happen with NGDP targeting. Then you can consider whether it is appropriate to call that policy “inflation.” I’d like to use July 2008 as the benchmark. This was 7 months after the peak of the previous boom and unemployment had risen to 5.6%. That’s also the Fed’s estimate of the


considered malicious viruses. This type of virus is rare since no perceptible advantage results to the creator of the virus in interfering with keyboard functions.

Computer cleaning products we’ve tried can’t cut through the layers of finger oil, so we turn to you. How do you keep your laptop’s exterior squeaky clean? We’re not talking about blowing dirt and dus.

EdocTransfer is a malicious site that seeks to infect its visitors with malware. EdocTransfer virus is a malicious domain that must be avoided. According to the latest researches, this domain is associated with various phishing campaigns used by Internet frauds to infect their visitors with malware. EdocTransfer.com domain was noticed for the first time in phishing campaigns delivering.(1) distribution of factual materials at the initial contact (0 month), (2) distribution of general and testimonial materials within 1 month after the initial contact, and (3) a one-time on-site session that included dissemination of additional materials and expert- and volunteer-led discussions within 1 month of receiving the second stage of the intervention.

*Model B*: Two intervention performances delivered over two stages: (1) distribution of factual and testimonial materials at the initial contact (0 month) and (2) an on-site session that included dissemination of materials and expert- and volunteer-led discussions within 1 month after the initial contact.

*Model C*: Factual materials, testimonial materials and a one-time, on-site session that included dissemination of materials and expert- and volunteer-led discussions were delivered upon the initial contact (0 month).

Interviews and data management {#Sec6}
------------------------------

We


materials and volunteer and expert-led discussions has a much greater effective on promoting behavior change of male participants in Western China. The involvement of peers, partners, and medical college students likely played an important role in encouraging participants to retain and internalize knowledge on MC and to take action on seeking MC surgery^[@CR26],[@CR27]^.

While this study reveals some important information regarding the effectiveness of educational interventions on increasing acceptance and uptake of MC, there were several limitations to this study. First, the 9-month follow-up time of our program was very short, and thus greatly limited our ability to accurately assess the impact of MC on acquisition of HIV or other STIs. As a result, during the follow-up period of our study, no participants acquired HIV infection. In addition, theprevention of sexual transmission in this region.

Bo Zhou, Chuanyi Ning and Chase D. McCann contributed equally to this work.

**Publisher\'s note:** Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

We thank all collaborators and participants in MC investigation group from Xinjiang Medical University, Chongqing Medical University, and Guangxi Medical University for their contribution to the project. The study was supported by Natural Science Foundation of Guangxi Province, China (GXNSFBA139165), Guangxi Medical University Youth Science Foundation (GXMUYSF2014020), and the Molecular Biology of Viral Diseases Predoctoral Training Grant (NIAID; 5T32AI007419-24). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Conceived and designed the study: H.L., L.Y. Recruited subjects and performed the investigations: B.Z., X.Y., J.J.,


to a deep tomb of roses:
At the last moment she lifts remembering eyes.
Green leaves blow down. The place is checked with shadows.
A long-drawn murmur of rain goes down the skies.
And oaks are stripped and bare, and smoke with lightning:
And clouds are blown and torn upon high forests,
And the great sea shakes its walls.
And then falls silence . . . And through long silence falls
This melody once more:
'Down endless stairs she goes, as once before.'
So says the tune to him—but what to me?
What are the worlds I see?
What shapes fantastic, terrible dreams? . . .
I go my secret way, down secret alleys;
My errand is not so simple as it seems.infinity = Succ infinity

Let’s partially instantiate Num just so we have something to play with.

instance Num Nat where Zero + y = y Succ x + y = Succ (x + y) Zero * y = Zero Succ x * y = y + (x * y) fromInteger 0 = Zero fromInteger n = Succ (fromInteger (n-1))

We wish to construct this function:

search :: (Nat -> Bool) -> Maybe Nat

Which returns a Nat satisfying the criterion if there is one, otherwise Nothing . We assume that the given criterion is total, that is, it always returns, even if it is given infinity . We’re not trying to solve the halting problem. :-)

Let’s try to write this in direct style:

search f | f Zero = Just Zero | otherwise =


Transcriptome analysis of newly classified bZIP transcription factors of Brassica rapa in cold stress response.
Plant bZIP transcription factors play crucial roles in biological processes. In this study, 136 putative bZIP transcription members were identified in Brassica rapa. The bZIP family can be divided into nine groups according to the specific amino acid rich domain in B. rapa and Arabidopsis thaliana. To screen the cold stress responsive BrbZIP genes, we evaluated whether the transcription patterns of the BrbZIP genes were enhanced by cold treatment in the inbred lines, Chiifu and Kenshin, by microarray data analysis and qRT-PCR. The expression level of six genes increased significantly in Kenshin, but these genes were unchanged in Chiifu. These findings suggest that the six genes that encoded proteins containing N-rich regions might beslightly bigger than the traced lines, but this will allow you to center punch each circle so that the outer diameters are even all the way around. Also, be careful when you start drilling because the plastic surface is somewhat slippery. I managed to make a nice groove in the outer face of the console when the center bit of the hole saw slipped sideways.

Once the holes are drilled, the outlets themselves are not difficult to install. I ended up placing the triple mounting plate behind the console wall rather than mount it on the outside. I also removed the rubberized caps from the outlets before installation. Both of these changes helped to give the install a cleaner look – closer to stock. Removing the caps does make


portion at each end to allow the wires to separate for hook up). I did the same procedure for the grounding wires. The wire loom not only helps to keep the wires together, it also helps prevent unwanted abrasion due to vibrations around metal parts.

Although it’s not always the case, I try to make a habit of soldering and heat shrinking any connectors on the ends of my wires. This helps prevent unwanted grounding, loose connections, and just looks better from a cosmetic standpoint. I used female spade connectors for the ends of the wire that mount to the back of the 12v outlets, and ring connectors for the end that hooks to the fuse panel. With the console flipped upside down, I attached the two bundles ofsleep apnea \[[@CR30]\], have provided growing support to potential functional airway benefits of RME.

Since changes in nasal volume alone seem inconclusive to account for the effects of RME, alternative explanations are now being explored. One of such hypothesis is the effect of RME on the nasal septum. Data from computational fluid dynamic studies that have modeled nasal septal deviations have been valuable in providing \[[@CR31], [@CR32]\] comprehensive information on nasal airflow characteristics. These studies concluded that anterior and inferior septal deviations increase nasal resistance more than posterior and superior septal deviations \[[@CR31], [@CR32]\]. Consequently, significant septal deviations in the posterior nasal cavity can occur without significant increase in nasal airway resistance. This is explained due to the fact that in healthy nasal passages, majority of the airflow is


the conclusions were based on visual and subjective assessment of X-rays without any objective quantification of change or appropriate statistical analysis. The issue again with this study was that although it is stated that nasal septum improvement was visually assessed, a percentage of correction was not stated.

Finally, Schwarz et al. reported \[[@CR19]\] in nine adult patients that underwent surgically assisted maxillary expansion without including nasal septum sectioning failed to notice any nasal septum anatomical change. Coronal tomograms were used to quantify the before and after nasal septum symmetry.

Only two studies \[[@CR15], [@CR21]\] were finally included in this systematic review after conducting electronic searches of several databases. Both analyzed the change in nasal septal deviation from RME in two-dimensional coronal views from posterior anterior cephalograms. Farronato et al. \[[@CR15]\]Related literature   {#sec1}
====================

For the biological activity of substituted pyridine derivatives, see: Yao *et al.* (1994[@bb5]). For a related structure, see: Vishnupriya *et al.* (2014[@bb4]).

Experimental   {#sec2}
==============

Crystal data   {#sec2.1}
--------------

C~26~H~16~ClN~3~*M* *~r~* = 405.87Monoclinic,*a* = 7.6533 (4) Å*b* = 11.4822 (7) Å*c* = 23.2906 (14) Åβ = 94.351 (1)°*V* = 2040.8 (2) Å^3^*Z* = 4Mo *K*α radiationμ = 0.21 mm^−1^*T* = 293 K0.50 × 0.25 × 0.20 mm

Data collection   {#sec2.2}
-----------------

Bruker Kappa APEXII CCD diffractometerAbsorption correction: multi-scan (*SADABS*; Bruker, 2004[@bb1]) *T* ~min~ = 0.958, *T* ~max~ = 0.98615210 measured reflections4194 independent reflections3000 reflections with *I* \> 2σ(*I*)*R* ~int~ = 0.028

Refinement   {#sec2.3}
------------

*R*\[*F* ^2^ \> 2σ(*F* ^2^)\] = 0.051*wR*(*F* ^2^) = 0.146*S* = 1.044194 reflections271 parametersH-atom parameters constrainedΔρ~max~ = 0.38 e Å^−3^Δρ~min~ = −0.40 e Å^−3^

 {#d5e434}

Data collection: *APEX2* (Bruker,


at C1, correlating well with the values observed in the *ortho*-substituted derivative. The carbonitrile group lies almost in the plane of the attached planar pyridine ring system.

The crystal structure features a N3---H3···N2^(i)^ \[symmetry code: (i) 2 - *x*, 2 - *y*, -*z*\] hydrogen bonded *R*~2~^2^ (16) motif (Fig. 2). No significant π---π stacking interaction between neighboring aromatic rings or C---H···π interaction towards them are observed.

S2. Experimental {#experimental}
================

A mixture of 3-(1*H*-indol-3-yl)-3-oxopropanenitrile 1 (1 mmol), 4,4,4-trifluoro-1-phenylbutane-1,3-dione 2 (1 mmol) and 4-chloro benzaldehyde 3 (1 mmol) in the presence of ammonium acetate (400 mmol) under solvent-free condition was heated at 110 °C for 6 h. After completion of the reaction (TLC), the reaction mixture was poured into water and extracted with dichloromethane. After removal of the solvent, the residue was chromatographed
  C14   0.3902 (4)     0.8774 (2)     0.06809 (14)    0.0895 (8)
  H14   0.4130         0.9510         0.0835          0.107\*
  C15   0.4297 (5)     0.8525 (2)     0.01292 (14)    0.1014 (10)
  H15   0.4846


officer equipped with a Motorola P25 APX 7000 Portable Radio stood in the back of the room. A Motorola MCC 7500 IP Dispatch Console sat in the front of the room.

After pointing out a blip on the screen that showed where the officer was, the officer began running. The blip changed colors to indicate he was in foot pursuit.

When he made it to the front of the room, he pulled his OC and deployed. Again, the blip shifted, indicating a change in the situation.

Finally, he pulled his gun, and the blip responded.

The software can also be programmed to turn on the camera in the lapel microphone when a certain event occurs (such as an officer’s weapon being unholstered).

Pretty impressive. This technology would allow a dispatcher to see thatprovide a user with richer information about activity occurring within his or her environment.
Elements in the figures are illustrated for simplicity and clarity and have not necessarily been drawn to scale. For example, the dimensions and/or relative positioning of some of the elements in the figures may be exaggerated relative to other elements to help to improve understanding of various embodiments of the present invention. Also, common but well-understood elements that are useful or necessary in a commercially feasible embodiment are often not depicted in order to facilitate a less obstructed view of these various embodiments of the present invention. Certain actions and/or steps may be described or depicted in a particular order of occurrence while those skilled in the art will understand that such specificity with respect


each functional aspect individually. To evaluate cell viability, HUVEC were treated with increasing concentrations of drug or isotype control for 72 h, followed by the addition of the MTS tetrazolium compound, which undergoes a color change when bioreduced by metabolically active cells. While little to no effect of IgG was observed at the ng/ml range (data not shown), IgG at the μg/ml range inhibited HUVEC viability. At this dose range, TRC105 (μg/ml) elicited comparable inhibition to IgG (μg/ml) alone, suggesting the inhibition observed in response to TRC105 was an IgG non-specific effect. In regular medium, bevacizumab showed no appreciable inhibition on HUVEC viability when tested at concentrations of 100 ng/ml to 1 μg/ml (Fig. [2a](#Fig2){ref-type="fig"}). Higher concentrations of bevacizumab (100 μg/ml to 1 mg/ml) were also tested, but again, the effects were negligible (datacontains important structural elements that serve as docking sites for multiple adaptor proteins, such as zyxin, zyxin-related protein 1 \[[@CR33]\], β-arrestin2 \[[@CR34]\], and GIPC \[[@CR35]\]. It remains unclear how TRC105 binding to endoglin would affect these proteins and what role (s) the intracellular domain of endoglin plays in TRC105 function.

Clinically relevant doses of TRC105 were tested in these in vitro cell-based assays and could facilitate our understanding of the efficacy in vivo. Based on the superior effects of TRC105 and bevacizumab in HUVEC tube formation assays, the combination of both drugs has the potential to increase drug efficacy and reduce resistance. Currently, developing rationale-based combinations of multiple anti-angiogenic agents is a favored strategy to overcome resistance in the clinic \[[@CR36]\]. Bevacizumab has been successfully added to chemo- and


on the inhibiting element and is opposed to the parasitic forces. If the amount of this restoring force is greater than the critical force, e.g., the maximum parasitic force occurring during a force impulse, the inhibiting element can no longer move in an uncontrolled manner toward the free position.
However, an additional risk is inherent in exerting a restoring force on the inhibiting element. As is known, a mobile mass on which a restoring force acts forms an oscillator with at least one resonant frequency. Such an oscillator can be resonantly vibrated by excitation with a suitable frequency and the amplitude of these vibrations, as a function of the damping present, can be very considerable. Under this effect, the locking device could be undesirably opened by external influences.
In orderin summer the path of the sun is right over our heads and above the roof so that there is shade."

From this point on, most civilizations have oriented their structures to provide shade in the summer and heating in the winter. The Romans improved on the Greeks' design by covering the southern-facing windows with different types of transparent materials.

Another simpler example of early solar architecture is the cave dwellings in the southwestern regions of North America. Much like the Greek and Roman buildings, the cliffs in which the indigenous people of this region built their homes were oriented towards the south with an overhang to shade them from the midday sun during the summer months and capture as much of the solar energy during the winter


Structures of the (+)- and (-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyre ne adducts to guanine-N2 in a duplex dodecamer.
The structures of the mirror image (+)- and (-)-trans-anti-adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene to guanine N2 have been of great interest because the high biological activity of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mammalian mutagenesis and tumorigenesis has been attributed to the predominant (+)-trans-anti-adduct. We have carried out new potential energy minimization studies, involving wide-scale conformational searches on small modified DNA subunits, followed by energy-minimized build-up techniques, to generate atomic resolution views of these adducts. These energy-minimized duplex dodecamers were then subjected to 100-ps molecular dynamic simulations with solvent and salt to yield animated molecular structures. The most favored computed structure for the (+)-adduct places the pyrenyl moiety in the B-DNA minor groove, with its long axis directed toward the 5'to fighting for what she wants, keeping a cool head, and doing whatever it takes to protect her daughter Janie. But "whatever it takes" has never before included a shotgun wedding to a dangerous-looking stranger with an attitude problem....

Storm's Heart: Elder Races Series #2

During the rule of her murderous Dark Fae uncle, Thistle "Tricks" Periwinkle found sanctuary among the Wyr in New York. Her ethereal beauty and sparkling personality won the hearts of the public, but after her uncle's death, there are those who don't want to see her ascend to the throne. Able to wield thunder and lightning, Wyr sentinel Tiago Black Eagle has ruled the skies for centuries. He's sent to protect Tricks when she's almost assassinated in Chicago....

A Sorceress of His Own: Gifted Ones, Book


I hope will come. Unfortunately that is what most of this book is, ground work, but there is some good action at the end and some very interesting questions posed at the end. It will be interesting to see if what I think and hope happens to Nick. Now that the ground work has been done, I look forward to the next book in this series as well as the next in her Elder Race series.

It was a good short story but there were so many metaphors there were times I lost track of where she was in the story. I also found the narrator to be too slow and "flowery" of a tempo. Not really sure if I liked it or not. So this one gets aNEWS & ANNOUNCEMENTS

Experiential learning (EL) connects learners with practical experiences to increase and apply disciplinary knowledge, develop transferable skills and collaborate with communities. But how does EL reshape the teaching and learning mission of the university? Does this recast the ‘town and gown’ connection? Read the proceedings of an EL roundtable held at Western with faculty, staff, students and community partners. Read more

Angelica Lucaci honoured with Western Award of Excellence

Geography's Undergraduate Assistant and Program Advisor, Angelica Lucaci, has been selected as one of this year's recipients of the Western Award of Excellence. This award is Western’s highest level of recognition for staff members and focuses on exemplary service, creativity and innovation, the ability to share knowledge and expertise and their capacity to foster their values of integrity and


respect across campus. Read more

Western-led youth advisory council calls to prohibit vaping in schools

London’s youth are troubled by the rising prevalence of vaping in public schools. The HEAL Youth Advisory Council (HEALYAC) informs youth-related health research conducted by the Human Environments Analysis Laboratory (HEAL) at Western University. The HEALYAC recommendations are based on a careful review of existing research and the students own personal experiences as teens. Read more

'Harry Potter' election signs appear on London, Ontario street

Wes Kinghorn, a soon-to-be Western University geography assistant professor, has put a fun spin on election signs to curtail political tensions as we edge closer to the federal election. "Kinghorn told CTVNews.ca that “closer to the election, there can be a lot of divisiveness in our politics which is normal. That happens.So I think it’s kind of fun to put something out there that everyone can get behind.”" Read more

DEPARTMENT INTRANET

EXPLORE GEOGRAPHY AT WESTERN

DID YOU KNOW?

Geography is the study of places and the relationships between people and their environments. Geographers examine how human culture interacts with the natural environment and the way that locations and places can have an impact on people. Geography uniquely bridges the social sciences with the natural sciences.

The Geography program at Western was established in 1938, by Dr. Edward G. Pleva.


/*
    Copyright (c) 2003-2020, Sveinbjorn Thordarson <sveinbjorn@sveinbjorn.org>
    All rights reserved.

    Redistribution and use in source and binary forms, with or without modification,
    are permitted provided that the following conditions are met:

    1. Redistributions of source code must retain the above copyright notice, this
    list of conditions and the following disclaimer.

    2. Redistributions in binary form must reproduce the above copyright notice, this
    list of conditions and the following disclaimer in the documentation and/or other
    materials provided with the distribution.

    3. Neither the name of the copyright holder nor the names of its contributors may
    be      QuerySpec spec = splitter.getSpec(entry.getValue());
            assert spec != null;
            Source source = new Source(entry.getValue(), spec);
            this.sources.put(entry.getKey(), source);
        }
        return splitter;
    }

    /**
     * Returns an orderBy containing only orderings which are not already pushed down to sources. The optional is only
     * pressent if there are orderBySymbols left. The existing orderBy is returned if it
     * there are


There are no simple criteria for ranking the NFL’s head coaches, 1 through 32. Wins and losses aren’t enough, nor are Super Bowl wins, playoff appearances, longevity or the eyeball test.

It’s also quite a challenge to figure it all out in June, while teams are in OTAs, with a lot of draft picks still unsigned or unavailable, injuries already playing havoc with a coach’s chances to prove himself (hello, Jason Garrett; sorry about Sean Lee) and with seven new head coaches. Four of them have never been NFL head coaches before, period. What fun to rank them now!

All that being said, there is one fairly reliable rule of thumb: Start with Bill Belichick and work your way down.

It’s going to be a long time before any coach isFox, Broncos

When you take two different franchises to Super Bowls in just over a decade, it doesn’t matter if either of them had Peyton Manning. One of them didn’t, of course, the 2003 Panthers, so he can do far more than steer a Hall of Fame quarterback toward the huddle. He has the respect of his players and his colleagues — and this season, he may be loaded enough to get that last piece of hardware left.

9

of 32

Jim Harbaugh, 49ers

The 49ers’ brass had better be smart enough to hold onto him, because the transformation he’s engineered there is borderline miraculous. Not every front office, roster or fan base can handle his style, and he willingly takes on a ton of heat — but he has yet to prove


since the end of the Jon Gruden era. The Bucs will get better, but Smith also faces a beast of a division.

15

of 32

Chip Kelly, Eagles

Not many debut better than Kelly did in Philadelphia last season, proving to be the exact fresh face with fresh ideas the franchise needed. Taking the next step is a challenge, but no bigger a challenge than living up to the hype he brought from his college days. The challenge is tougher now that he has to prove that putting his foot down with now-departed DeSean Jackson was the right move, short term and long term. Philly fans have short memories and short tempers.

16

of 32

Jim Caldwell, Lions

If only he were more demonstrative, more colorful, more … coach-y? Also, if only he’d won more thanWhat do you have to confess or do you have a secret to share?

Main menu

Post navigation

I’m afraid !!

There is this guy he’s my best friend for 3years and every time we do silly stuffs to each other and when am with him i feel very safe , happy and so special but he told me his secret that she like this girl and i felt really jealous after that when i got home i lock myself on my room and wrote all the things that happened and after that i really really cried a lot because i was really afraid that he will leave me and spend some more time with the girl she likes then the day i was afraid come came my best friend now has


night.

The tweet comes one day after 29-year-old Sayfullo Saipov steered a truck into cyclists and pedestrians down a Manhattan bike path before being shot and taken into police custody. On Wednesday, Trump called for harsh punishment for Saipov, describing the US justice system as "a joke and a laughing stock" and saying he was considering sending the suspect to the military prison at Guantanamo Bay in Cuba.

But Wednesday night's tweet was a startling escalation of rhetoric in legal proceedings that have barely begun, let alone led to a sentence. Federal prosecutors filed terrorism charges against the suspect, an Uzbeki immigrant, on Wednesday.

Law-enforcement officials who spoke to Saipov on Wednesday said the suspect told them he was " proud" of his actions and requested a flag of the Islamic1. Technical Field
Th present invention relates to thermometer-code signal conversion and, in particular, to a thermo-decoder circuit capable of converting a binary signal to a corresponding thermometer-code signal.
2. Discussion of Related Art
Modern electronics often require interfacing signals between analog and digital systems. For example, a digital audio signal is converted into an analog signal prior to playing the signal through an audio speaker. Similarly, many digital video signals from digital media sources are converted to an analog form prior to viewing on an analog display. Accordingly, digital signals are converted into their analog equivalents in many electronic devices.
Digital-to-analog converters (“DACs”) are widely used to convert a digital signal into a corresponding analog signal, thereby allowing for communication between analog and digital systems. Some DAC designs, however, exhibit poor


lawless, unpunished (often rewarded) behavior of many member states just now -- such as Iran, rewarded for violating the Non-Proliferation Treaty by being fast-tracked to building nuclear weapons; Russia, which invaded Ukraine with no push-back; and China, which has been building military land-fill islands throughout the South China Sea while encountering no serious negative response -- why shouldn't the leaders of Hamas employ a practice illegal under the Geneva Convention -- using the civilian population in Gaza as hostages -- to protect themselves, and dub the impending civilian casualties as "Israeli crimes against humanity"?

By contrast, any perceived infraction by Israel of the even most trivial nature is treated as an international catastrophe.

The horror is that so many corrupt countries go along with it to protect their own corruption.

Morevoid send(std::string message);
                static std::string get();

};

// .cpp file
#include<string>
#include<iostream>

#include "ActiveMQWrapper.h"

void ActiveMQWrapper::send(std::string message){
        std::cout<<message;
}

std::string ActiveMQWrapper::get(){
        return "test";
}

// test file
#include <string>
#include <iostream>
#include "ActiveMQWrapper.h"

int main() {
        std::string foo ="test";
        ActiveMQWrapper::send(foo);
        std::cout<<ActiveMQWrapper::get();
        return 1;
}

When I added the following to .h file, hell breaks loose. Do you think I should seperate this impl to a factory and initialize and instance and return to the wrapper above? How do i deal with all the dependencies?
private:


it.  It is says that the class has no object-oriented value, and that it exists solely for organization.
Because C++ doesn't have to shoehorn everything into the OO paradigm, it provides proper constructs to express this: namespaces.  A namespace behaves just like a static class in other languages.  It contains a number of functions, variables or even classes.  What I would do, then, is put your get() and send() functions in a namespace.
namespace activeMQWrapper
{
    void send(std::string message)
    {
        // Put your code here.
    }

    std::string get()
    {
        // And here.
    }
}

I don't knowof 432 records of patients who underwent imaging-guided breast biopsy with placement of Gel Mark Ultra clip were reviewed. Of these, 63 (15%) patients required definitive surgical intervention, for which 41 cases were localized with ultrasound and assessed for margin clearance. Clear margins were achieved in 37 (90%) of the 41 cases. These results are statistically superior (P < .01) to positive margins rates reported in the literature. The Gel Mark Ultra biopsy site marking system is a new localization device that provides a safe and effective alternative to traditional localization methods with a significant reduction in the percentage of positive margins, as well as advantages in terms of surgical approach, time, and patient comfort.


into the hand. Travelers carried these lamps at night so that they could see the terrain where they were walking.

It’s worth noting that the Word is described as being a “lamp”, not a high-powered searchlight. The lamp of olden days gave light to the feet, but couldn’t give light for a great distance. That’s the way it is with God – He gives us just enough to see the next couple of steps but not the complete pathway. Why? I think it is because if we had a high powered searchlight, we wouldn’t need faith, for then we would be walking by sight and not by faith. God wants us to learn to trust Him with a future that is unknown (to us).

Are you trying to direct yourown steps? Sometimes we can try to hard to plan the future and we rob ourselves of the excitement and joy of being led step by step. Our planning tends to remove God and dependence on Him from our minds. We must approach all of life with the attitude noted in James 4.13-15: “So you should say, ‘If the Lord wants, we will live and do this or that.'” How often in the course of planning your day, let alone your week, month, year or life, do you stop to take God’s sovereignty into account?

Living day by day, depending on Him alone, is a tremendous adventure. Don’t try to find the searchlight – be content with the lamp and trust that He truly knows the path.

PRAYER: Give us