of the measured events should not change. Figure 2 and Figure ED2 present the results of such an analysis for the Influx and Fortessa cytometers, respectively and show clear evidence of coincidence (large changes in population median intensities with dilution) for scatter-based measurements in both instruments. Fluorescence trigger-based measurements do not show such large changes, although the measured intensities are so low and close to background that decreases would be hard to measure. Nonetheless, these data nicely illustrate this common artifact, as the superiority of fluorescence-triggered particle measurements over scatter-triggered analysis.

2\. The authors use beads and synaptosome preps stained individually and then mixed for analysis to illustrate the occurrence of coincidence and aggregation, two phenomena that can be hard to distinguish. They show that coincidence can be amelioratedand antibody staining, we note that we did indeed include 5% BSA in the blocking buffer (along with 0.1% Tween20) which was present during permeabilization, primary antibody staining, and secondary antibody staining. We agree that repeated centrifugation-based washes are a disadvantage of the immunostaining protocol, as our data in Fig. 5D and new Fig. 8 show that this is likely to bias towards aggregates. However, we had previously conducted a 'no wash', direct immunostaining protocol using Fab-AlexaFluor488-labeled primary antibody (using Invitrogen Zenon technology) followed by dilution and flow cytometry without centrifugation, as the reviewer suggests. As shown below for GluR1 (a subunit of AMPA glutamate receptors), the results are similar, but the direct protocol resulted in a lower signal compared to the indirect, AlexaFluor488-conjugated secondary protocol.

We therefore chose


we have extended our relationship with Respawn. I'm very happy about that. Vince and the team there are amazing. We look forward to doing stuff with them for a long time to come. But right now we're focused on the current Titanfall property."

Zampella was equally coy. "Don't know yet!" he said when I asked him what Respawn's next game would be. "No decisions have been made. That'll be next week!"

EA raised eyebrows by not announcing sales of Titanfall - a decision some took to indicate it had performed poorly. But Wilson told me the game beat sales expectations.

"Yeah!" he said enthusiastically. "Our expectations were high and it beat them."

An exact sales figure is unknown. EA COO Peter Moore told investors in a May 2014 financial call that Titanfallsupporting it you can justify putting people and resources on it.

"If there's not that many people, or the engagement goes down, there's a point where those resources are better spent on whatever our next game would be and making that game better. I hope it lasts a really long time and we can do more stuff."


tactical orientation should be based on the larger political trends, opportunities and challenges.

Ruling class fears a renewal of anti-capitalist militancy

The ruling class wants the Sanders campaign to be diminished not because he is a dangerous revolutionary socialist, which he is not, but because his campaign is starting to legitimize a broader discussion of what’s wrong with the U.S. economic system and to generate enthusiasm for socialism even if the term is still vague and not well understood.

This campaign comes just three years after U.S. law-enforcement agencies arrested 7,000 people and broke up their encampments in public places. “We are the 99%” caught on like wildfire. It scared the hell out of the bankers, and the government went into mobilization mode, sending its cops to break up the movement.platform that is far to the left of the other politicians. But, come August 2016, if Sanders has failed in his bid he promises to do what Jesse Jackson did in 1984 and 1988. That is, to fold his progressive tent and tell his followers to vote for the establishment Democratic Party candidates so as to prevent the Republicans from capturing the White House.

This is the dilemma created for leftists by the carefully constructed political system in the United States. In a parliamentary system, such as exists in most of the capitalist countries, Sanders could run independently from the Democrats and in competition with the Democrats and still win a sizable part of the general vote and a significant number of parliamentary seats. Any combination of parties and


to the Sanders supporters

The PSL has its own election campaign with Gloria La Riva and Eugene Puryear running for president and vice-president. The campaign has a 10-point program. It is clearly more far reaching than the Sanders campaign program, and unlike Sanders’ program it is consistently anti-imperialist.

Of course, we will point out all the political differences that we have with the Sanders campaign. We are in complete solidarity with the Palestinian people and their right to be self-determining rather than living under brutal occupation, for instance. Also, Sanders wants a carefully crafted and cautiously used drone program, but the PSL condemns the Pentagon drone program because it constitutes a war crime and reflects the criminal nature of U.S. imperialism. The PSL does not want the Wall Street banksinto service. May this prayer site anchor your day and strengthen your resolve to remember what truly matters.

September 12, 2015

Holy Name of Mary

Lk 6: 43-49

No good tree bears bad fruit, nor again does a bad tree bear good fruit;for each tree is known by its own fruit. Figs are not gathered from thorns, nor are grapes picked from a bramble bush. The good person out of the good treasure of the heart produces good, and the evil person out of evil treasure produces evil; for it is out of the abundance of the heart that the mouth speaks. “Why do you call me ‘Lord, Lord,’ and do not do what I tell you? I will show you what someone is like who comes to me, hears my words,


It’s all quite a balancing act, both technical and human.

This September Saturday, as I look back on the week just ended and the one to come, how am I constructing, reinforcing, repairing the building of my personal, family, and/or spiritual life? What
does my spiritual construction company look like? No doubt the building will proceed more smoothly if Mary and Jesus and my favorite saints are on the payroll.

—The Jesuit Prayer Team

Prayer

Holy Mary, mother of God, pray for us sinners,
now and at the our of our death. Amen.lipidic vesicles, increased number of residual bodies). They may be responsible for anomalies in biomineralization processes. The detection of sulfur in deformed specimens suggests that foraminifers may have a detoxification mechanism with production of a metallothionein-like protein.


Major depressive disorder (MDD) is a leading cause of total disability with inadequate treatment options and unresolved etiology. However, increasing evidence suggests that genetic and environmental vulnerabilities may converge on deficits of GABAergic transmission as a possible, causative core symptom of MDD. Other lines of research point to changes in glutamatergic transmission as being associated with MDD. In particular, subanesthetic doses of the NMDAR antagonist ketamin have rapid and lasting antidepressant effects even in otherwise drug-resistant forms of MDD, pointing to altered function of NMDA receptors. We have established GABA-A receptor gamma2 subunit heterozygous mice as an animal model with excellent construct, face and predictive validity of partially drug resistant MDD. Preliminary data show that GABA-A receptor deficits in gamma2 subunit heterozygous cultures result in markedly reduced expressionMaintenance of muscarinic tone after vagotomy in the lung periphery.
We developed a method for maintaining muscarinic tone in a small region of the lung periphery after vagotomy. A fiber-optic bronchoscope was wedged in a segmental airway of anesthetized male mongrel dogs and was used to deliver aerosols of distilled water (0.1 ml), neostigmine (0.022 mg), atropine (0.1 mg), and histamine (1.5 X 10(-4) mg). Measurements of resistance through the collateral system (Rcs) were used to monitor responses to these agents. Rcs increased 37.0 +/- 5.0% (mean +/- SE) after the administration of neostigmine and remained elevated for at least 50 min. The administration of neostigmine in vagotomized animals or in those where the obstructed lung segment was pretreated with atropine resulted in a small increase in Rcs that


the emergence of widespread 24-hours news coverage on cable news programs, and the rise of the internet during the same period.’ Johnston recommended a media pact to ‘no longer share, reproduce, or retweet the names, faces, detailed histories or long-winded statements of killers, we could see a dramatic reduction in mass shootings in one to two years.’”

Shapiro argues that “the value of public knowledge regarding specific names and photographs of mass shooters is significantly outweighed by the possibility of encouraging more mass shootings.” Even if the Johnston and Joy study is overzealous in its conclusions, I concur with Shapiro that the risk overshadows the reward tremendously.

I do not publish the names or images of mass shooters on How to Cure Your Liberalism, and I never will. I hopeif the total charge of \[A$_3$B’\] is odd, it induces a half-integer oxidation state in M, i.e., a mixed (or intermediate) valence of the transition-metal ion [@Byrne1970]. In this case, having an odd number of electrons per dimer ensures a finite spin moment in the ground state. Various different valencies are possible including $d^{4.5}$ in iridates with trivalent B’ [@Doi2004; @Sakamoto2006], $d^{3.5}$ in ruthenates with trivalent B’ [@DOI2002; @Senn2013; @Ziat2017] or iridates with monovalent B’ [@KIM2004], and $d^{2.5}$ in ruthenates and osmates with monovalent B’ [@Stitzer2002; @Stitzer2003]. Such materials have been less explored theoretically, despite the fact that their experimental magnetic response reveals several peculiarities. At high temperatures, where the mixed-valence dimers can be seen as isolated, magnetic susceptibility deviates from the conventional Curie-Weiss behavior [@DOI2002; @Sakamoto2006; @SHLYK2007] suggesting a non-trivial temperature evolution of


filling. For intermediate values of $\tilde{\lambda}$ found in real materials, this also has the effect of confining the $j_{1/2}$ bonding and $j_{3/2}$ antibonding levels into a narrow energy range, which significantly reduces the energy scales relevant to the magnetic response of the dimer. The consequences for specific fillings are considered in sections \[sec:d45\]–\[sec:d25\] with inclusion of Coulomb interactions.

Definition of Effective Moments {#sec:moments}
===============================

Given that we are interested in dimers with open-shell (e.g. doublet) ground states, it is useful to characterize them according to their magnetic response. For isolated magnetic ions or dimers, it is conventional to describe the molar magnetic susceptibility in terms of temperature-dependent effective moments $\mu_{\rm eff}^\alpha (T)$, defined by: $$\begin{aligned}
\chi^\alpha (T) = \frac{N_A}{3k_BT}[\mu_{\rm eff}^\alpha (T)]^2 \label{eq:effmom}\end{aligned}$$ where $\alpha \in \{x,y,z\}$. In simple cases where there are nocase of $d^{4.5}$ filling that corresponds to three holes per dimer. This filling can be found in [[A$_3$B’M$_2$O$_9$]{}]{} with trivalent B’ and M = Rh or Ir, among which mostly the iridates have been studied experimentally. All of them show strong deviations from the Curie-Weiss behavior and develop a characteristic bend in the inverse susceptibility at $50-100$K [@Sakamoto2006]. The linear fit to the high-temperature part returns the effective moments of 1.53$\mu_B$/f.u. (B’ = In) and 1.79$\mu_B$/f.u. (B’ = Sc) that were interpreted as the $S=\frac12$ state of the mixed-valence dimer [@Sakamoto2006], although very high Curie-Weiss temperatures of several hundred Kelvin put into question the validity of such a fit. Below the bend, a much lower effective moment of 0.76$\mu_B$/f.u. (B’ = In) is obtained [@Dey2017], and a magnetic entropy on the


$S=3/2$ moments for all values of $\tilde{U}$. The crossover from the low-spin to high-spin ground state with increasing $\tilde{U}$ leads to a reversal of the anisotropy of the effective moment; for small $\tilde{U}$, $\mu_{\rm eff}^{ab}<\mu_{\rm eff}^c$, while for large $\tilde{U}$, $\mu_{\rm eff}^{ab}>\mu_{\rm eff}^c$. We expect that hypothetical Rh-based dimers should fall into the latter category.

In the region of parameters applicable to Ir-based dimers ($\tilde{\lambda}=1.4$; Fig. \[fig:d45\](c)), increasing $\tilde{U}$ leads to a phase transition from a $J_{\rm eff} \approx 3/2$ to $J_{\rm eff} \approx 1/2$ ground state, which is marked by a significant increase of the average effective moment. The average moment in the $J_{\rm eff} \approx 3/2$ state is strongly suppressed by SOC, and displays an anisotropy that is strongly sensitive to various parameters such as $\tilde{\lambda}, \tilde{U}, \tilde{\Delta}$,$\tilde{\lambda}$, this level crosses the $j_{1/2}$ bonding level of $e_{1/2}$ symmetry, leading instead to a ground state with $J_{\rm eff} \approx 1/2$ nature. Finally, further increasing $\tilde{\lambda}$ leads to another crossing of the $e_{1/2}$ level with an $e_{5/2}$ level that is nominally $j_{3/2}$ anti-bonding. As a result, the ground state in the $\tilde{\lambda} \to \infty$ limit consists of two holes in the anti-bonding $j_{1/2}$ level ($e_{5/2}$), two holes in the bonding $j_{1/2}$ level ($e_{1/2}$) and one hole in the antibonding $j_{3/2}$ level ($e_{5/2}$). This latter $J_{\rm eff} \approx 3/2$ ground state is smoothly connected to the high-spin $S=5/2$ state appearing at weak SOC.

In Fig. \[fig:d35\](c), we show the evolution of the zero-temperature effective moment as a function of $\tilde{U}$ for $\tilde{\lambda} = 1.4$, corresponding to $5d$ materials. In this


is generally weak. In Fig. \[fig:d25T\](d) and (e), we show the temperature dependence of $\mu_{\rm
eff}$ for $\tilde{\lambda} = 1.1$ and $1.6$, corresponding to the $J_{\rm eff}
\approx 1/2$ and $J_{\rm eff} \approx 3/2$ ground states, respectively. The green area in Fig. \[fig:d25T\](d) shows the region where the first excited state is filled. The energy of the first excited state in Fig. \[fig:d25T\](e) is above 0.2 $t_2$. For the latter case, the suppressed $\mu_{\rm eff}^{ab}$ discussed above is observed only at relatively low temperatures, below room temperature ($\tilde{T} = T/t_2
\sim 0.1$). The theoretical results can be compared with the experimental $\sqrt{(3k_BT/N_A)\chi_{\rm avg}(T)}$ for Ba$_3$BOs$_2$O$_9$ (B = Na, Li) based on data from Ref.  shown in Fig. \[fig:d25T\] (f). In principle, the experimental powder data may be consistent with both possible ground states; single-crystal measurementsthe inhibition of cholesterol synthesis in the body.
The enzymatic biosynthesis of cholesterol is a complex process which requires altogether some 25 reaction steps. The pathway can be divided into three stages: (1) the conversion of acetic acid to mevalonic acid; (2) the conversion of mevalonic acid into squalene; and, (3) the conversion of squalene into cholesterol. In the last stage of cholesterol biosynthesis, squalene is converted to squalene 2,3-epoxide via oxidation, a reaction catalyzed by squalene monooxygenase, also known as squalene epoxidase. The squalene 2,3-epoxide then undergoes cyclization to lanosterol, the first sterol to be formed; the cyclization of 2,3-oxidosqualene to lanosterol is catalyzed by the microsomal enzyme 2,3-oxidosqualene lanosterol-cyclase (squalene cyclase). Inhibition of either squalene epoxidase or squalene cyclase would result in the inhibition of cholesterol synthesis


online service, the services also allow subscribers to link to the much larger resources of the Internet." Id. (emphasis in original). "The major commercial online services have almost twelve million individual subscribers across the United States." Id. Approximately six million individuals are subscribers of AOL.
23. There are a number of different ways to communicate over the Internet. One such way "is via electronic mail, or `e-mail', comparable in principle to sending a first class letter. One can address and transmit a message to one or more other people." Id. at 834.
24. "[T]he content on the Internet is as diverse as human thought." Id. at 842.
25. "Communications over the Internet do not `invade' an individuals's home or appear on one's computer screen unbidden. Users seldom encounter content `by accident.'"280. Our Court of Appeals has noted that "Marsh has been construed narrowly." Cable Investments, Inc. v. Woolley, 867 F.2d 151, 162 (3d Cir.1989).[2]
By providing its members with access to the Internet through its e-mail system so that its members can exchange information with those members of the public who are also connected to the Internet, AOL is not exercising any of the municipal powers or public services traditionally exercised by the State as did the private company in Marsh. Although AOL has technically opened its e-mail system to the public by connecting with the Internet, AOL has not opened its property to the public by performing any municipal power or essential public service and, therefore, does not stand in the shoes of the State. Marsh is simply


entities, who cooperate to allow their constituent parts to be interconnected by a vast network of phone lines.
11. In order for non-AOL members to send Internet e-mail to AOL members, non-AOL members must utilize a combination of their own hardware and software, the Internet and AOL's network.
12. To obtain its initial access to the Internet, AOL obtained an Internet address and domain name from IANA, a clearinghouse that routinely and ministerially assigns Internet addresses and domain names.
13. Cyber, an advertising agency incorporated in 1996, provides advertising services for companies and individuals wishing to advertise their products and services via e-mail.
14. Cyber sends its e-mail via the Internet to members of AOL, members of other commercial online services and other individuals with an Internet e-mail address.
*449 15. AOL providesthat Cyber has hired new counsel, it is asking the Court to adopt additional findings in Reno which it believes will help its case. Although we are under no obligation to do so in the context of a motion for reconsideration, we will nevertheless adopt the following findings in Reno in order to have a complete record:
27. "[Communications over the Internet] can occur almost instantaneously, and can be directed either to specific individuals, to a broader group of people interested in a particular subject, or to the world as a whole." Reno, 929 F.Supp. at 831.
28. "Full access to the online service (including access to the Internet) can be obtained for modest monthly or hourly fees." Id. at 833.
29. ".... the Internet provides an easy and inexpensive way


advertisements from clogging AOL's system and damaging AOL's reputation while at the same time not receiving any compensation whatsoever from Cyber.

ORDER
The motion of Cyber Promotions, Inc. for reconsideration of our Memorandum Opinion and Order of November 4, 1996 is DENIED.
Pursuant to 28 U.S.C. § 1292(b), the following question is certified for an immediate appeal: Whether, under the First Amendment to the United States Constitution, one private company has the unfettered right to send unsolicited e-mail advertisements over the Internet to the e-mail servers of a private online company and whether the private online company has the right to block the e-mail advertisements from reaching its members.
The Court is of the opinion that the foregoing involves a controlling question of law as to which there is substantial ground forYork State Energy Research and Development Authority (NYSERDA). The policy overhaul is taking place through a number of initiatives driven by the Public Service Commission. These include:

Reforming the Energy Vision — an overarching proceeding that will change the rules for utility companies, determine who has access to and ownership over New York’s energy resources, and create new markets for distributed energy resources, such as rooftop solar, small-scale wind, energy efficiency, demand response, microgrids and other small generators (including diesel and gas). Read more.

Clean Energy Fund — an initiative to decide how much money the state will collect on utility bills to put toward clean energy subsidies and programs and to determine what those programs will look like. This is the first major rethinking of these policies since the


json.NewDecoder(response.Body).Decode(&cinfo)
	if err != nil {
		return nil, err
	}
	return &cinfo, nil
}

func (self *HTTPContainerInfoGetter) GetContainerInfo(host, podID, containerID string, req *cadvisorapi.ContainerInfoRequest) (*cadvisorapi.ContainerInfo, error) {
	return self.getContainerInfo(
		host,
		fmt.Sprintf("%v/%v", podID, containerID),
		req,
	)
}

func (self *HTTPContainerInfoGetter) GetRootInfo(host string, req *cadvisorapi.ContainerInfoRequest) (*cadvisorapi.ContainerInfo, error) {
	return self.getContainerInfo(host, "", req)
}
A. Field of the Invention
This invention relates to the field of bicycle handlebars. More particularly, in the preferred embodiment the invention is a strong, lightweight fiber-reinforced plastic handlebar for all-terrain bicycles (i.e."mountain bikes"). The invention includes a method for making the desired handlebar as a one-piece unit with the aid of an injection molding process.
B. The Background Art
It is desirable in the bicycle arts to replace conventional metal bicycle parts with fiber-reinforced plastic parts. In many applications, fiber-reinforced plastic parts are preferred because they typically offer lighter total weight, inherent shock absorption due to the nature of fiber-reinforced plastic materials, durability, a high-tech appearance and in some cases, lower manufacturing costs.
Due to the preferences of typical bicycle consumers, only fiber-reinforced plastic parts which conform to conventional bicycle appearance,


Measured for Transport | Channel Islands | Under the Wires | Points and Aspects | Scotland for SportDisc Five: Berth 24 | Peak District | Train Driver | Give Your Car a Holiday | Just the Ticket | England’s North CountryDisc Six: Away for the Day | They Had an Idea | Manhandling | List, Stolen, Damaged | Go As You Please in Britain | It Takes All Sorts | Just Like the Rest of Us

Note: Previously released in individual volumes.

Following the nationalisation of transport in 1948 the British Transport Commission set up its own in-house film production unit. Launched on 1 May 1949, and led for 25 years by Edgar Anstey – a foundling father of the British documentary movement – it became one of the largestQ:

Mirror formatting spring-data-rest/spring-hateoas in custom controllers

I used the suggested approach in this question to return HATEOAS formatted outputs that match those returned by spring-data-rest. It works good, but is there a way to avoid boiler plate code to create entity resource assemblers like the QuestionResourceAssembler in the referenced question, if I only want to add 'self' links using the id to all entities? Perhaps using ResourceAssemblerSupport?

A:

The easiest way is to simply use the Resource wrapper type:
Resource<Person> personResource = new Resource<>(person);
personResource.addLink(…);
personResource.addLink(…);

Links can be created either by simply instantiating them (i.e. new Link("http://localhost/foo", "relation") or by using the ControllerLinkBuilder which allows you to point to Controller methods for obtain a reverse mapping. See this section of the Readme for details.


five men. Thus, although this group does not reflect a normal population, it does reflect typical patients attending urology clinics for investigation, and in whom malignancy can be excluded with a high degree of certainty. For the expanded normal control group, 755 men were recruited in total. In all, 331 men were identified from this group as potential controls after exclusion of men \<50 years old with either a history of bladder or prostate cancer, cancer identified during investigation or a positive NMP22 result (\>7 U ml^--1^). The median age of this group was 68 years (IQR 59--75 years). For 55 men in this expanded cohort, PSA measurements were available. The median value was 1.8 ng ml^--1^ (IQR 0.8--4.95 ng ml^--1^). The presenting complaints were asymptomatic nonvisible haematuria (*n*=75), symptomatic nonvisible haematuria (*n*=50), visiblehaematuria painless (*n*=124), visible haematuria painful (*n*=46), haematospermia (*n*=3) and unrecorded/other (*n*=33). Normal findings were identified in 154 men. Benign prostatic hyperplasia/obstruction was identified in 73, urinary calculi in 30, prostatitis in 7, urinary tract infection in 36, urethral stricture in 10, nephrological disease in 6 and other benign diagnoses in 15 men. This larger group contained men with no identifiable or previous cancer, but with the exception of a small group tested with PSA, no specific tests to exclude prostate cancer were made and thus a degree of contamination with occult tumours is to be expected.

Urinary Mcm5 detection in prostate cancer patients and normal controls
----------------------------------------------------------------------

The cohort of 88 prostate cancer patients recruited for study together provided 83 pre-massage and 60 post-massage urine samples for Mcm5 immunofluorometric analysis.


a more accurate diagnostic test was available. Crucially, the disproportionate number of cancers that must be treated to prevent one death underlines the inadequate understanding of prostate cancer biology. Future diagnostic methods must not only reduce unnecessary prostate biopsies, but also provide prognostic information to aid treatment decisions. Moreover, the ideal diagnostic marker would preferentially identify clinically significant prostate cancers with a high risk of progression.

In this study we have identified Mcm5 as a potentially important biomarker for prostate cancer detection. Principally, we have shown that Mcm5 levels are elevated in the urine cell sediments of prostate cancer patients when compared with patients without malignancy. Only two patients had an elevated Mcm5 signal in the strictly normal control group. Interestingly, both patients presented with haematospermia and normal clinicalBoomerracks is a social enterprise in St. Louis, Missouri that seeks to engage young entrepreneurs in an effort to sustain local youth mentoring programs. Boomerracks has invested it's attention into the youth of the St. Louis area by encouraging the use of their talents in the construction of "green", useful and fun bike rack structures.

Boomerracks combines existing bike parts with Kee Klamp pipe fittings to create unique bike racks that stand out on the urban landscape. The program places an emphasis on the reuse and recycling of existing materials -- "giving new life to what would otherwise become waste".

Kids in the Boomerracks program get the opportunity to build several vital skills:

They work with their hands and grow in their mechanical abilities.

They use their creativity to imagine new structures


if I didn't have a policy of endorsing incumbents." Cheri Bustos, the head of the House Democrats' campaign arm, said Cuellar “is going to be fine,” rejecting the notion that he is at all vulnerable.

Besides being overwhelmingly Latino, the district also encompasses some of the state’s poorest ZIP codes. That’s not unrelated to the fact that it also has some of the lowest voter turnout rates in Texas.

Although that would appear as an obstacle for a new candidate, Cisneros sees it as a new frontier.

“I definitely don’t see it as a problem; I see it as an opportunity,” she said.

Although Cuellar’s war chest outweighs the amount Cisneros has raised so far, she still outraised his campaign by $100,000 in small-dollar donations. Donations under $250 aren’t trackable, so it’smax-cache-size

Specifies
the maximum number of beans allowable in cache. A value of zero indicates
an unbounded cache. In reality, there is no hard limit. The max-cache-size
limit is just a hint to the cache implementation. Default is 512.


CA). Each sample is prepared by adding 300 μL of 30% aqueous ethanol solution and 50 μL of the internal standard solution (which consists of the deuterated estradiol in methanol) to 200 μL of the serum. The ethanol solution is used to break up the ionic interaction from the carrier protein to release the analyte without precipitating. After vigorous mixing, the samples are incubated at room temperature for 15 to 20 minutes prior to being placed in the refrigerated autosampler for injection into the Aria TLX System (Thermo Fisher, San Jose, CA). Following injection, the sample is loaded onto a high flow rate extraction column. This creates turbulence inside the column, which allows the steroids to bind to the large particles of the extraction column, while protein and otherthe filing of a petition ... unless the court deems, for good cause shown, that a continuance should be granted." Wife filed her petition on December 23, 1996. The January 17, 1997, hearing was twenty-five days after the filing of the petition. Although the trial court noted the matter had been continued for good cause, husband argues the record does not support the court's action because no pleading for a continuance had been filed, no showing of good cause had been made, and no written finding as to what constituted "good cause" was included in the court's notation.
Even if we were to assume, arguendo, the cause was continued erroneously and the hearing resulting in the full order of protection was held beyond the fifteen-day period prescribed by the


proceeding in which child abuse or neglect is alleged.
Id. In the instant case, though mother brought her action pursuant to the Adult Abuse Act's provisions, the trial court was responsible for determining who should have temporary custody of the parties' son, as well as whether a visitation schedule should be established. RSMo §§ 455.045(3) and 455.050.3(1)-(2). Moreover, wife's petition contained several allegations concerning husband's abuse of son, in addition to her request for custody of the child. These allegations included an incident where husband placed a pillow over the child's face when he was crying, and said he would make the child stop crying, and another incident where husband threw a rocking chair through the windshield of a car while the child was inside the vehicle. Therefore, weappear at the top of the message body. As another example, if the content of the message is protected by an encryption mechanism, an indicator indicating that the message is encrypted could appear at the top of the message body.
Other examples of indicators used to convey information about the state of the message include but are not limited to: indicators representing the trust status or revocation status of the digital certificate whose corresponding private key is used to sign a digitally signed message; indicators representing the state of any digital certificates that are attached to the message; and indicators representing whether the sender of the message asked that a signed receipt be sent when the message is read by the recipient.
In one implementation of secure email processing, determining


and displaying the image, text, and any other information applicable to indicator, requires considerable processing time. Many of the secure email encoding methods in current use are complicated. Furthermore, extraction of the required information from a particular encoded message in order to determine and to construct an applicable indicator can be time-consuming.that the server is slow to respond. Therefor in those few seconds it takes the server to send a response someone could edit another field thus overwriting the current values. Is there some way to instantiate the variables so they don't overwrite?

A:

The variables won't be affected if the user will change the values of the HTML elements.
If you want the user to know the changes he will do won't affect because the request ha been sent already. just disable the elements.
beforeSubmit: function() {
            editBtn.hide();
            fieldText.prepend(loading);
            $('#form_eline input, select, textarea').prop('disabled', true);


897 F.2d 729
STATE FARM FIRE AND CASUALTY COMPANY, Plaintiff-Appellant,v.Douglas C. BARTON, Defendant-Appellee.STATE FARM FIRE AND CASUALTY COMPANY, Plaintiff-Appellee,v.Douglas C. BARTON, Defendant-Appellant.
Nos. 89-2324 and 89-2330.
United States Court of Appeals,Fourth Circuit.
Argued Jan. 9, 1990.Decided March 5, 1990.

Jeter E. Rhodes, Jr., argued, G.D. Morgan, on brief, Whaley, McCutchen, Blanton & Rhodes, Columbia, S.C., for appellant.
James Marcus Whitlark, argued, David A. Fedor, David E. Massey, on brief, Fedor & Massey, Columbia, S.C., for appellee.
Before POWELL, Associate Justice (Retired), United States Supreme Court, sitting by designation, and RUSSELL and HALL, Circuit Judges.

POWELL, Associate Justice:

1
The question presented is whether the district court erred in denying appellant's JNOV and new trial motions.  We hold that the district court properly denied these motions, except to the extent that it upheld the jury's verdict awarding consequential  On January 26, 2001, at approximately 8:30 a.m., Portsmouth

Police Officer S.W. Johnson was conducting a narcotics

surveillance operation at a Portsmouth Redevelopment and Housing

     * Pursuant to Code § 17.1-413, this opinion is not
designated for publication.
Authority property.   Concealed from observation since 5:00 a.m.

and employing binoculars to aid in the surveillance, he observed

a white, four-door Chrysler with handicapped tags pull up in

front of a residence.    Officer Johnson had observed the vehicle

in the area earlier that morning.

     A person known to the police exited the back seat and

entered the residence.   A man and a woman subsequently

approached the passenger side of the vehicle and began speaking

with the passenger, later identified as Mark Ward.


Ward's hand go down to his lap, then to

his mouth.   When Officer Smith opened the passenger door he saw

Ward chewing.   Officer Smith did not see the actual item that

Ward placed in his mouth.   However, based on his police

                                - 2 -
experience, Officer Smith believed Ward was placing drugs into

his mouth to prevent the police from recovering the evidence.

       Officer Smith grabbed Ward and placed his hand on the back

of Ward's jaw to prevent him from swallowing.      He repeatedly

told Ward toThat is the same figure as the winning bidder, Cintra Concesiones Infraestructuras de Transporte SA.

The difference came in how much money the tollway authority said it could pay over the life of the 50-year toll contract: $4.2 billion vs. Cintra's $700 million offer.

"Is it preliminary? Yes. Is it less than certain? Absolutely," said tollway authority board Chairman Paul Wageman. "But to me, it shows the tremendous strength of our system. It also demonstrates that all of the money will stay in the region."

The agency developed the estimates after a March 2 request from state Sen. John Carona, R-Dallas, who has questioned the rush to form public-private partnerships for urban-area toll roads.

"I was not surprised. As many of us have said for some time, public-private partnerships bear closer scrutiny,"


the Malaysia-based step-down subsidiary Sabah. Bilt has mega brands such as bilt Royal Executive Bond, bilt Copy Power, bilt Image Copier and bilt Matrix that have now become an integral part of office stationery. SuppliersOf Paper Mills in India, view 28 suppliers of Paper Mills in India on m including Ballarpur Paper Mills(Unit of Ballarpur Industries Limited Shree Jagdambe Paper Mills Limited. Ballarpur Industries Recruitment 2018 -. (bigph bilt Graphic Paper Products Limited (bgppl Sabah Forest Industries (SFI Malaysias largest pulp and paper company. SuppliersOf Paper (except Newsprint) Mills in India. The company markets its stationery through a well-established network of 350 retail distributors spread over 270 locations. The company has a dominant share of the high-end coated paper segment in India. Here is a list of topST. PETERSBURG, Fla. -- Authorities and a fugitive holed up in an attic fired more than 100 shots at each other Monday in a firefight that killed two officers, wounded a deputy U.S. marshal and led to an hourslong standoff that ended when the suspect was found dead inside the home.

St. Petersburg Police spokesman Michael Puetz said the suspect was found dead when officers went into the home Monday afternoon, about six hours after the shootout, the latest in a recent rash of shootings across the nation that have killed or wounded law enforcement officers.

Law enforcement had been at the home to arrest Hydra Lacy Jr., 39, around 7 a.m. on an aggravated battery charge, and investigators believe he is the one who opened fire on the officers,


ones at the house and were told by a woman that Lacy was in the attic. The three called for backup, and soon after

Jeffrey Yaslowitz, 39, and Tom Baitinger, 48, arrived. Police had initially said they were among the first three to arrive.

The chief said Yaslowitz and the marshal, who was not identified, went up to the attic and exchanged fire with the suspect. Both were hit. Yaslowitz went down in the attic, while the marshal tumbled to the first floor after being hit in his bulletproof vest and lower torso.

Baitinger was one of several officers who came to rescue the other two and was hit when Lacy fired through the attic floor.

Hostage negotiators arrived, and the SWAT team exchanged more gunfire with the suspect. The SWAT teamInterferon-gamma modulates the fibrinolytic response in cultured human endothelial cells.
The fibrinolytic potential of the endothelial cells gives important antithrombotic properties to the vascular wall. Thrombosis is a frequent complication to atherosclerosis and other conditions where inflammatory mediators are present in the vascular wall. Inflammatory agents like lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF alpha) have been demonstrated to modulate the expression of fibrinolytic factors in cultured endothelial cells. In the present study the expression of tissue-type plasminogen activator (t-PA), urokinase plasminogen activator (u-PA) and plasminogen activator inhibitors-1 and -2 (PAI-1 and PAI-2) antigen in conditioned medium from cultured human umbilical vein (HUVEC) and human saphenous vein (HSVEC) endothelial cells was investigated under basal conditions and after stimulation with LPS, TNF alpha, interferon-gamma (IFN-gamma) or interleukin-6 (IL-6) alone or


to four of the five seats, with India and Britain competing for the fifth. Repeatedly over 11 rounds, the UNGA, made up of 193 countries, voted overwhelmingly for Dalveer Bhandari, while the 15-member Security Council voted 9 to 5 in favour of Britain, which is one of five permanent members of the security council. India is currently not a member.

In all previous such contests, the candidate who got a majority in the General Assembly was eventually elected, but Britain was at one point seen to be pushing for a joint conference mechanism, never resorted to since the UN was established and only once before that.March 19, 2017 – Morning Worship

Carl McCray, Pastor

Scripture tells us in Romans 3:23 “all have sinned.” Sin is bad news, and the consequence is eternal separation from God. Praise the Lord that God intervened in what we call the Gospel! The Gospel is the Good News that God became man in Jesus Christ. He lived a life we should have lived and died a death that we should have died in our place. God intervened. Three days later we know He rose from the dead proving that he is the Son of God and offering the gift of salvation for all who repent and believe the Gospel. God intervened. God saves dead people!

When we partake of the Lord’s Supper, we express our love for what Jesus had done


that he remembers that night," Brookes added.

Whether the FBI will examine Kavanaugh's alcohol consumption as part of its supplemental investigation isn't clear. James Roche, one of Brett Kavanaugh's freshman year roommates at Yale, tweeted Monday that the FBI had never contacted him "for any of their background checks. "

"I assume college behavior was not a topic of interest. They did not find Debbie's story because they were not looking for it." Roche said referring to allegations from Ramirez.

Roche previously said in a statement that Kavanaugh "became aggressive and belligerent when he was very drunk."

According to a 1985 police report obtained by CNN , Kavanaugh was accused of starting an altercation at a bar while he was an undergraduate student at Yale.

A man named Dom Cozzolino said Kavanaugh hadthrown ice on him and Kavanaugh's friend Chris Dudley had thrown a glass that hit him in the ear, according to the report from the New Haven, Connecticut, police department. Cozzolino "was bleeding from the right ear," according to the report, and was later treated at a local hospital.

Ludington told CNN's Chris Cuomo on "Cuomo Prime Time" on Monday that he was with Kavanaugh and Dudley that night. Kavanaugh responded to an aggressive statement from Cozzolino by throwing ice at him, Ludington said, sparking a fight. They had all been drinking at a bar after attending a UB40 concert.

Dudley denied the allegations, according to the police report, "and Mr. Kavanaugh didn't (want) to say if he threw the ice or not. "

The police report does not indicate whether


" Fall back!" " He's right." " What do you mean he's right?" "You know, you and him ran Briggs off." " You think Briggs is innocent?" " Hell, yes, I do." "Look, Briggs don't deal drugs, and he don't kill FBI agents." "And you don't run when you're innocent." " What about the fugitive?" " That's a movie, Johnny." "Everybody stop pointing fingers, okay?" "You want to be mad at somebody, be at the person who's not here." "Because the five of us..." "we are stuck in this together." "Okay." "We're done with the rooms." " Thank you." " Thank you!" "Doesn't matter." "We're not gonna be together much longer anyway." " What does that mean?" " That means they're not gonna keep letting us surf andsays he knows where Briggs is." "I don't know how long I'll be able to track him." "Listen to me." "I want you out of this." "I'll hit you guys when I'm done." "Mike." "What'd he say?" "Hello?" "Anybody home?" "Don't make me drink alone." "[Keys jingling]" "[Gun cocks]" "Gun on the ground!" "Now!" "Remember me now, you son of a bitch?" "Huh?" "Hmm?" "Hello?" "I'm here." "Paul?" "Get off him, Paul." "Don't do this, Charlie!" " I said off!" " This man is Jangles." "I'm telling you." "I'll shoot you, Paul." "I swear to God." "Get off him." "Let him go!" "[Coughing]" "I'm telling you, this is him." "You met him in a hotel room where I set a trap." "He burned down the estate." "[Hoarsely] He's


Did you hear?" " Yeah." "An innocent man." "Mmhmm." "Mike filled us in." "So, uh, where is everybody?" " Bonfire." " You should join them." "It'd be nice for us to be together again." "Charlie, why don't you go ahead?" "I'm gonna steal Briggs for a minute." "You can help me with the cooler." "Yeah." "[Bottles clinking]" "Is it done?" "It is done." " And the recorder?" " Who knows?" " So we're even?" " Oh, more than, brother man." "Good." "Now fix this place." "Look what I found." "Yo..." "Little Simba returning to pride rock." "Yo, what's up, bro?" "How you doing?" "[Grunts] Good to have you back, man." "Good to be back." "You know, guys, there's not a set of faces in the world that make  int   h,		// I - Height of area to read
	      int   alpha) {	// I - Alpha value for image (0 for none)
  uchar *base;
  int rowBytes, delta;
  if(fl_window == NULL) { // reading from an offscreen buffer
    CGContextRef src = (CGContextRef)fl_gc;   // get bitmap context
    base = (uchar *)CGBitmapContextGetData(src);  // get data
    if(!base) return NULL;
    int sw = CGBitmapContextGetWidth(src);
    int sh = CGBitmapContextGetHeight(src);
    rowBytes = CGBitmapContextGetBytesPerRow(src);
    delta = CGBitmapContextGetBitsPerPixel(src)/8;
    if( (sw - x < w) || (sh - y < h) )  return NULL;


with Mark Zuckerberg and Tesla with Elon Musk. Does this prove that only visionary leaders create truly successful and innovative companies? How many visionary leaders have failed to create successful and innovative companies? This is much harder to answer than the first question. We only know about success stories, failures do not get the same publicity.

The passion for a visionary value proposition

All of the above named leaders are not only visionaries from a product or services point of view. They are passionate about a value proposition for their customers. Bill Gates core value proposition was productivity gains, Steve Jobs was design and function, Jeff Bezos is price and customer service, Mark Zuckerberg is social sharing and Elon Musk is sustainable clean energy. The products are a means tothat makes up the new business model.

The value proposition shapes much; it identifies and defines where this business model is providing new offerings that advance on existing benefits to customers. The fluidminds business model canvas seeks out the customer and the customer benefit- it is looking to provide value by identifying where there is a clear fresh, new proposition.

We do have to recognize a value proposition is not just looking to resolve the known jobs-to-be-done. In many new business models can be bringing together often fragmented parts of existing offerings and combining them in new ways, or deliberately and completely disrupting existing businesses through adapting new insight, technology advancements or understanding, into new business models. We only need to think of Apple and how it combined different technologies,


/*
 * Copyright 2017 47 Degrees, LLC. <http://www.47deg.com>
 *
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at
 *
 *     http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
 */

package com.fortysevendeg.ninecardslauncher.services.persistence.data

import cards.nine.commons.test.data.CommonValues._
import cards.nine.commons.test.data.WidgetValues._
import cards.nine.repository.model.{Widget, WidgetData}

trait WidgetPersistenceServicesData {

  def repoWidgetData(num: Int = 0) =
    WidgetData(
      momentId =Q:

Dynamic Worksheet Title Reference Optimization

Scenario:   I have a workbook that needs to be able to dynamically reference different worksheets based on user input. I was able to achieve this by using several INDIRECT functions and some other basic functions such as INDEX.
My problem is that the workbook is taking several minutes to load on a fairly powerful computer with no other strenuous processes running.
Question:  Is there a simple way to optimize workbooks? I tried looking online for some standard methods to run through to catch unnecessarily strenuous processes to no avail. I am willing to use VBA if it would help speed the sheet up.
Thanks

A:

Don't use INDIRECT or any other volatile functions (OFFSET, RAND, NOW, TODAY) in your workbooks if you can help it,


be re-crunching those numbers pretty much every time you touch the mouse or keyboard. Yikes!
But that’s not the half of it: After Excel recalculates those functions, it merrily starts recalculating all cells downstream of them—regardless of whether those downstream cells have volatile functions in them. And regardless of whether anything actually changed as a result. And I mean all cells...not just the cells that directly point to your volatile functions but all the cells that point to those cells, and then the next bunch of cells that point to that last bunch, and so on and so on, all the way through your workbook. If you’ve used volatile functions at key points within a spreadsheet, pretty much the entire spreadsheet could be recalculating constantly. Double yikes!
But even thisthose institutions that, like aging athletes, have outlived their glory days and taken up residence in their own long shadows.

The economic turmoil that has rocked the city, the nation and the world in recent months has defined Ms. Fierro’s reality for the past two years. Rubyfruit is a portrait in miniature of these large-scale troubles, one of countless unassuming businesses around the city being battered by forces beyond their control and sometimes deeply mysterious to them.

“I had this formula that worked,” Ms. Fierro said. “But then it didn’t work anymore.”

A Play Without the Props

Photo

I had this formula that worked, said Debra Fierro, the owner of Rubyfruit Bar and Grill. But then it didnt work anymore.Credit
Michelle V. Agins/The New York Times

For about 12 years, Rubyfruit got along, never making


(4.4,-0.3) node [$2$]{}; (5.6,-0.3) node [$2$]{}; (6.8,-0.3) node [$2$]{};

(5,3.3) node [$1$]{}; (4.4,2.3) node [$1$]{}; (5.6,2.3) node [$1$]{}; (3.8,1.3) node [$1$]{}; (5,1.3) node [$1$]{}; (6.2,1.3) node [$1$]{};

Consider the set of hyperedges $E_{k,q}$: observe that it can be written naturally as $$E_{k,q} = \{ e(\bb): \bb \in V_{k,q-1} \}.$$ I.e., the hyperedges can be identified one-to-one with the vertices in $V_{k,q-1}$. Recall that $e(\bb) = \{ \bb + \be_1, \bb + \be_2, \ldots, \bb + \be_k \}$. Two hyperedges $e(\bb), e(\bb')$ share a vertex if and only if $\bb' + \be_j = \bb + \be_i$ for some pair $i,j \in [k]$; or in other words if $\bb, \bb'$ are nearest neighbors in $V_{k,q-1}$ (differ by $\pm 1$ in exactly two coordinates).

Consider a labeling $\ell: V_{k,q} \rightarrow [k]$. For each $icall this kind of partition “Voronoi-type".[^5] We note that that for $\bz = (\frac{1}{k}, \frac{1}{k}, \ldots, \frac{1}{k})$ we obtain the Voronoi partition in Figure \[fig:Voronoi\]. Other choices of $\bz$ correspond to similar configurations where all the colors meet at the point $\bz$. Note that $\bz$ is the “rainbow point" guaranteed by the Knaster-Kuratowski-Mazurkiewicz Lemma.

First let us compute some basic quantities that we will need. The sides of our simplex $\Delta_k$ have length $\sqrt{2}$. Denote by $h_k$ the height of $\Delta_k$, that is the distance of any vertex from the opposite facet. We have $$h_k = \left\| (1,0,\ldots,0) - (0,\frac1{k-1},\ldots,\frac1{k-1}) \right\| = \sqrt{1 + (k-1) \cdot \frac{1}{(k-1)^2}} = \sqrt{\frac{k}{k-1}}.$$ The volume of the simplex can be computed inductively as follows; we have $\mu_1(\Delta_2) = \sqrt{2}$, and $ \mu_k(\Delta_{k+1}) = \frac{1}{k}


see Figure \[fig:Voronoi\]. Denote by $h'_i$ the distance of $\bz$ from the facet containing $S_i$. By the pyramid formula in dimension $k-2$, $$\mu_{k-2}(\mbox{conv}(S_i \cup \{\bz\})) = \frac{1}{k-2} h'_i \mu_{k-3}(S_i) = \frac{h'_i}{(k-2)!} \sqrt{\frac{k-1}{2}}.$$ By a simple calculation, $\sum_{i=1}^{k} h'_i = h_k = \sqrt{\frac{k}{k-1}}$. The sets $\mbox{conv}(S_i \cup \{\bz\})$ are disjoint except for lower-dimensional intersections. Hence, $$\mu_{k-2}(S) = \sum_{i=1}^{k} \mu_{k-2}(\mbox{conv}(S_i \cup \{\bz\}))
 = \sum_{i=1}^{k} \frac{h'_i}{(k-2)!} \sqrt{\frac{k-1}{2}} = \frac{1}{(k-2)!} \sqrt{\frac{k}{2}}.$$

Thus the proof of Theorem \[thm:simplex-partition\] will be complete if we prove the following bound.

\[lem:sep-bound\] For every Sperner-admissible partition $(A_1,\ldots,A_k)$ of $\Delta_k$, $$\mu_{k-2}^-\left(\bigcup_{i \neq j} (A_i \cap A_j)\right) \geq \frac{k-1}{\sqrt{2}} \mu_{k-1}(\Delta_k)
 = \frac{1}{(k-2)!} \sqrt{\frac{k}{2}}.$$

We pursue an approach similar to the proof of Proposition \[prop:EV\], with some additional technicalities. The high-level approach is to shrink the sets $A_i$ somewhat, by excluding a small neighborhood of thein the proof of Lemma \[lem:sep-bound\], we define $S^* = \bigcup_{i \neq j} (A^*_i \cap A^*_j)$, $S^*_\epsilon = \{ \bx \in \Delta_k: \exists \by \in S, \| \bx-\by \| \leq \epsilon \}$, $A'_i = A^*_i \setminus S^*_\epsilon$ and $A''_i = A'_i - \epsilon' \be_i$, $\epsilon' = \epsilon \sqrt{2}$. In the case of the Voronoi partition, these sets are explicitly described as follows:

-   $A^*_i = \{ \bx \in \Delta_k: x_i = \max_{\ell \in [k]} x_\ell \}$,

-   $S^* = \{ \bx \in \Delta_k: \exists i \neq j, x_i = x_j = \max_{\ell \in [k]} x_\ell \}$,

-   $A'_i = \{ \bx \in \Delta_k: x_i > \epsilon' + \max_{\ell \neq i} x_\ell \}$,

-   $A''_i = \{ \bx - \epsilon' \be_i: \bx \in \Delta_k, x_i >


– (AD\_) – cycle; (B\_) – (AB\_) – (AZ\_) – (CZ\_) – (BC\_) – cycle; (C\_) – (BC\_) – (CZ\_) – (CD\_) – cycle; (D\_) – (CD\_) – (CZ\_) – (AZ\_) – (AD\_) – cycle;

(A\_) – (B\_) – (C\_) – (D\_) – cycle;

(AB\_) – (AD\_); (AZ\_) – (CZ\_); (BC\_) – (CD\_);

at (5.7,0) [$B_1$]{}; at (9,1) [$B_2$]{}; at (10.3,4) [$B_3$]{}; at (7,3) [$B_4$]{};

(A\_) circle (2pt); (B\_) circle (2pt); (C\_) circle (2pt); (D\_) circle (2pt);

In general, we do not know what the partition minimizing $\mu(\bigcup_{i \neq j}(A_i \cap A_j))$ looks like, even in the case of a non-regular simplex. We believe that the , should still be polyhedral (piecewise linear) for an optimal Sperner-admissible partition of any polytope.

(-3,0) node [ ]{};

\(A) at (, ); (B) at (, ); (C) at (,+ 28 for t.
4
Solve -9 = -7*g + 5 for g.
2
Solve -14*g - 40 = -6*g for g.
-5
Solve -5*i - 5*i = -50 for i.
5
Solve 6 = -133*u + 135*u for u.
3
Solve 2150*q - 2158*q = -24 for q.
3
Solve 72 = 17*f - 8*f for f.
8
Solve 3*r = 735 - 723 for r.
4
Solve -139 = 46*a - 507 for a.
8
Solve -4*f + 3 = 23 for f.
-5
Solve -4*g - 13 = 7 for g.
-5
Solve 2*w - 4 = -18 for w.
-7
Solve 987 = 5*b + 1012 for b.
-5
Solve y = -34 + 39 for y.
5
Solve 3*k - 16*k + 26 = 0 for k.
2
Solve 4 - 16 = -3*h for h.
4
Solve -90*i = -218 + 128 for i.
1
Solve 0 = -2*l - 28*l - 120 for l.
-4
Solve t


j.
3
Solve -24 = -68*p + 112 for p.
2
Solve r + 5 = 1 for r.
-4
Solve 0 = -10*m + 2*m - 32 for m.
-4
Solve 4650*u = 4652*u + 16 for u.
-8
Solve 7*o + 19 = -2 for o.
-3
Solve 4*l - 2 = -14 for l.
-3
Solve -6*d - 144 + 138 = 0 for d.
-1
Solve 18*c + 95 = -c for c.
-5
Solve -40*n = -95 + 375 for n.
-7
Solve 35*h - 1 = 36*h for h.
-1
Solve 7*a + 1410 - 1424 = 0 for a.
2
Solve -15*b = -22*b - 7 for b.
-1
Solve -3*b = -2*b + 1 for b.
-1
Solve -35*o + 12*o = 0 for o.
0
Solve -12*k = -4*k + 16 for k.
-2
Solve -169*p = -164*p - 15 for p.
3
Solve 7*l + 352 = 373 for l.
3
Solve 3*m +Q:

Virtualised Development Servers / Test Lab

I left mainstream development about 2 years ago to start my own company. Now we are finally ready to move out of the garage and employ extra developers.
When I left virtualisation was just taking off, and I started to use VMWare Fusion to run Windows XP/Vista/7 and several Linux distros.
What I want now however seems simple, but the numerous products both open source and commercial are quite confusing.
What I'd like:

Run VM in on a central rack of servers and storage
A GUI to manage these VM
Remote clients to be able to access these VM and run them locally - for compatibly labs and testing
Developers to be able to provision their own servers

Ideally it would be a free open source solution but I'm not


it?" " And if not, you'll report me?" " Well, it's an idea." "Why don't we go and have a drink somewhere and talk about that?" " Do I have a choice?" " Yes, tea or coffee!" "I'm sorry if I came on a bit strong, but I'm a historian." "Anytime a document is removed from the official archives it's lost forever." " Monsieur Historian here in Russia anytime a document is consigned to the official archives it is lost forever!" "Look I'm doing research into the former Soviet Union." "I think the addition of psychoanalysis could be very interesting." "I have an idea..." "You speak Russian and English, and you obviously know your way around." " I need an interpreter..." " You want a thief to workFather." " Why should I tell you anything about myself?" "You never tell me anything about yourself!" "Well do you think it's right to bring the dead back to life?" "Look me in the eye, Dr. Jung!" " What's wrong?" " I have to go." " Why?" " The Russian girl." "I dreamt she ran away." "Darling, come back to bed, it's only a dream!" "There she is, sleeping peacefully!" "Here the translation you wanted." " Oh, thanks." "Why are you so interested in this Sabina Spielrein?" "In German, Spielrein means "fair play"." "So?" "History has forgotten her, and that's not fair." "Yes, but why is it so important to you?" "I suppose, in a way that's what I'd like to be, a woman who plays fair." "We


dressed like this?" " Good afternoon." " Good afternoon." "Dr. Jung and Miss Spielrein." " We booked two single rooms." " No." "A double room!" "Remember?" "A double room with a double bed!" " Of course." " A nice big double bed, please." "Yes, Madame." "You're so cold." "What's the matter?" "I'm just so happy." "Then why are you crying?" "Damned happiness!" "That's what my mother used to say when we were small." "She meant to say "blessed" but I think she was right." "Damned happiness!" "I want to have your baby!" "Here, now." "I want to conceive a child!" "What are you saying?" "You're mad!" "Of course I am!" "It was you who first diagnosed it!" "But then you cured me so now I'm not mad anymore!"from Glasgow University." "You knew Sabina Spielrein in the White Nursery didn't you?" "Yes." "Come in, please." "What?" "I should stop pursuing you, Dr. Jung?" "Just because you're afraid of love?" "How do you do?" "I'm Dr. Jung's mistress." "We haven't met before, I'm Dr. Jung's mistress." "I'm so glad you could come!" "I'm Dr. Jung's mistress." "Hello, Dr. Jung's mistress." "I'm sleeping with doctor Jung, I'm his mistress." "My name is Sabina Spielrein, I'm Dr. Jung's mistress." "I came here in order to humiliate you." "But now that I'm here, all I want to do is reassure you tell you that I shall always love you and that I wanted to die, but now I am alive." "And that's your doing." "I shall never forget it!" "Pardon


dreamt I was a horse... ) (... galloping across an endless plain.)" "(Perhaps that's what my life is:)" "(... an endless plain.)" "(It's getting late, and I can't keep my eyes open.)" "(Best wishes." "The keeper of your soul.)" "Sabina Spielrein was truly extraordinary." "She always had time for those children with particular problems." "There was a little boy there who would sit under a table all day with his eyes closed." "His hands were clasped so tight it was as if his fingers were glued together." "Every morning, Sabina would think up some way of coaxing him out of his isolation." "She refused to give up, but however hard she tried it was impossible to get those hands apart." "Then, one day Sabina had a brainwave." "Thathowever I have used GLEW also.
I am using the GLFW to manage the OpenGL context and DevIL to load texures. I am building in VS2010.
Here is a link to my full source. (I have riped everything from my main program out and named variable as logicly as possible)
full source code
Code that mostly likely to cause the problem.
Loading the image with devIL and buffering to the GPU.
void loadImage(const char* imageFile)
{
    ILuint texid;
    ilGenImages(1, &texid);
    ilBindImage(texid);

    ilLoadImage(imageFile);

    int size = ilGetInteger( IL_IMAGE_SIZE_OF_DATA ) ;
    ilConvertImage(IL_RGBA, IL_UNSIGNED_BYTE);

    glActiveTexture(GL_TEXTURE0);
    glGenTextures(1,&textureBuffer);
    glBindTexture(GL_TEXTURE_2D, textureBuffer);

    glTexImage2D(GL_TEXTURE_2D,


        0,
         ilGetInteger(IL_IMAGE_BPP),
         ilGetInteger(IL_IMAGE_WIDTH),
         ilGetInteger(IL_IMAGE_HEIGHT),
         0,
         ilGetInteger(IL_IMAGE_FORMAT),
         GL_UNSIGNED_BYTE,
         ilGetData());

    glTexParameteri(GL_TEXTURE_2D, GL_TEXTURE_WRAP_S, GL_CLAMP_TO_EDGE);
    glTexParameteri(GL_TEXTURE_2D, GL_TEXTURE_WRAP_T, GL_CLAMP_TO_EDGE);
    glTexParameteri(GL_TEXTURE_2D, GL_TEXTURE_MAG_FILTER, GL_LINEAR);
    glTexParameteri(GL_TEXTURE_2D, GL_TEXTURE_MIN_FILTER, GL_LINEAR);

    ilDeleteImages(1, &texid);

}

Render function called from the main loop.
void render()
{
    glUseProgram(program);
    glBindVertexArray(vao);

    glBindBuffer(GL_ARRAY_BUFFER, dataBuffer);
   We will link to the live question page, where you can test yourself (for free!) and find the answer to these sample questions and more. We will also crosspost these daily questions in their respective Facebook groups, which are linked in context below, so you can discuss them with fellow test-takers there:

CISSP Question of the Day

In Object-Oriented Programming, encapsulation is also referred to as… ?

We will link to the live question page, where you can test yourself (for free!) and find the answer to these sample questions and more. We will also crosspost these daily questions in their respective Facebook groups, which are linked in context below, so you can discuss them with fellow test-takers there:

CISSP Question of the Day

As the network administrator of your organization, customers report


argues Simon Singh in this witty and insightful talk at the Cheltenham Science Festival. But while all great truths begin as heresies, not all heresies become great truths, cautions Singh – as he introduces his very own mathematical formula 'proving' the Teletubbies are evil Continue reading...Simon SinghMathematicsPhysicsScienceTechnologyData and computer securityMedical researchScience and scepticismPeople in scienceFri, 27 Apr 2012 10:30:00 GMThttp://www.theguardian.com/science/video/2012/apr/27/simon-singh-heresy-heart-science-videoGuardian Staff2012-04-27T10:30:00ZMarcus du Sautoy counts from zero to infinity - videohttps://www.theguardian.com/science/video/2012/apr/05/marcus-sautoy-counts-zero-infinity-video
The Oxford mathematician takes us on a journey through the history of numbers, including the invention of zero and the taming of infinity

Check out our brand new Newton Channel page for lots more science films Continue reading...ScienceMathematicsThu, 05 Apr 2012 09:56:00 GMThttp://www.theguardian.com/science/video/2012/apr/05/marcus-sautoy-counts-zero-infinity-videoMarcus du Sautoy2012-04-05T09:56:00ZThere's safety in numbers, says Marcus du Sautoy - videohttps://www.theguardian.com/science/video/2012/apr/05/patterns-nature-safety-in-numbers-video
The Oxford"♪ Baby did a bad, bad thing ♪" "♪ Baby did a bad, bad thing ♪" "♪ Baby did a bad, bad thing ♪" "It was e-mailed to campus inboxes." "Do you know who sent it?" "My guess is Tau Kappa Theta, the Jewish fraternity." " I'm not saying anything bad." " No, of course not." "I just think it was this video that provoked the fight" " at the interfaith rally." " And you want us to defend...?" "Jimal Mifsud." "Scholarship student in Science." "His family is in Jiddah, and he can't afford a lawyer." "Do you know his family?" "No, I am purely an interested bystander here who wants to see justice done." "Purely?" "There's a campus fistfight between a dozen Palestinian and Jewish youths, and


a good kid they're painting as a suicide bomber." "Bond hearing's today." "I'll be there." "Good, that's one piece of business." "What else might we handle that Young, Bachman and Meyers can't?" "I know that Eli Gold is working with you these days?" "I'm in need of some crisis management." " What's the crisis?" " Where's the management?" "Will you get, uh, Eli for us?" "And ask Will to step in." "Will?" "Sure." "He's late." "Overslept." "Must be from celebrating yesterday's victory." " Must be." " Hey, Mom, pick up the phone." "Hey, Mom, pick up..." "Hello, dearest daughter." "You sound happy." "I am happy." "I have my daughter on the phone." "What more could I desire?" "Look, I don't think I need a tutor." "Grace, we discussedwill be this:" "no plea bargains." "That's right." "Defense attorneys will be expecting the opposite." "So for the next two months," "I want you to hold the line on every single plea." "After that, you won't have to work as hard." "You get your enemy flinching, you'll never have to hit him hard again." "Your first complaint will be about investigator hours." "That's why I've hired an outside contractor until we can budget full time." "I want you to meet Sophia Russo." "She's good, and she's cheap." "Thanks!" "Relatively." "Mr. Florrick, I offered the defense six months on the college hate crime." "Should I walk it back?" "What's the law say?" "Three to seven years." "There's your answer." "The lawyer's Alicia, and she might come after your campaign


but you're being hard on her." "No." "She's a third-year associate on a partner track and she's treating us like peers." "That's all you're seeing." "My God, am I the only adult left here?" "Could everybody just put their emotions away?" "I've got to get to a meeting, unless you have some other stray observations for me." "Are we overdoing it?" "Diane thinks I'm going too hard on you." "Am I?" "Going too hard?" "All those late nights..." "No time off." "Buried... in work." "Up to my knees." "He's doing it again, Mom!" "He's doing it again!" "It's just my neighbors." "Come on, let's go to the bedroom." "No, no, no, no, no." "Don't move." "Don't move." "Leg is done, the chops are ready to go." "I'm just"Yeah." "Yeah." "Ow." "That's what it feels like." "Thanks." "I got to go." "I got to be somewhere at 8:45." "Really?" "That's specific." "Yup." "Be good." "ER:" "I'll get them to school on Monday." " You sure?" " Yeah." "Do we take our homework?" " Yes!" " Yes!" "So, you've hired a tutor for Grace?" "Yes, I did." "She's good, I think, and Grace likes her." "Or... she likes her now." "I'll keep an eye on that." "Oh, um, also," "Zach's girlfriend, Nisa-- her parents wanted us to come for dinner." "I'll tell her you're busy." "Yeah, yeah, tell her I'm..." "I'm busy." "Love you." "Love you." " Love you." " I love you." "You call if you need anything." "I'll be here."


of patients. Comparisons suggest caregivers\' mean proxy health utility scores for patients are lower than patients\' self-reported health utility scores on both the EQ-5D and HUI \[[@B19], [@B24], [@B26]--[@B28]\]. These differences may be due to the influence of caregiver-specific issues such as burden, which may be especially important when caring for moderate AD patients. One study of the EQ-5D and HUI reported that caregivers\' proxy HRQoL ratings were associated with their own levels of burden, rather than patients\' self-reported HRQoL ratings or patients\' scores on the Mini-Mental State Examination \[[@B29]\] for cognitive impairment \[[@B24]\]. Conversely, the authors of the same study wrote that caregivers\' proxy ratings on the EQ-5D or HUI are at least as reliable as patients\' own ratings on these scales.

The equivocal results in patients andfor the three other household income categories (i.e., 18.02% of Canadians had a total household income before tax between \$20.000 to \$40.000; 19.34% of Canadians had a total household income before tax between \$40.000 and \$60.000; 17.10% of Canadians had a total household income before tax between \$60.000 and \$80.000).

2.2. Data Collection {#sec2.2}
--------------------

Data were collected using a structured computer-assisted telephone interview (CATI). During the interview, participants were asked to answer general questions about sociodemographics, knowledge of AD, health-related quality of life, and whether they knew someone with AD. Further details of the study methodology have been published elsewhere \[[@B30]\].

### 2.2.1. Sociodemographics {#sec2.2.1}

Several variables were collected to control for sociodemographics differences between participants in terms of age, gender, income, education (high school or less; at least some technical or


statistics and regression outputs are presented in terms of weighted results. For comparison purposes, we also present the unweighted results for participants\' sociodemographics characteristics.

The study received ethics approval from the Hamilton Health Sciences/McMaster Faculty of Health Sciences Research Ethics Board (Reference no. 08--179).

3. Results {#sec3}
==========

3.1. Study Participants {#sec3.1}
-----------------------

[Table 1](#tab1){ref-type="table"} presents participants\' unweighted and weighted sample characteristics. Starting with the unweighted results, the mean age of the unweighted sample was 51.8 years (median age: 51.0 years). Most were female (61%) and working (56%), and 37% had at least some university education. Forty-two percent of the sample reported that they knew a family member or close friend with AD. As the sample was weighted to have more individuals in the highest income category and less in the lowest income category,undertaken to compare AD patients\' ratings with general public and caregiver proxy ratings to assess potential validity issues, for example, the possibility of inverse correlations between patient ratings and general public proxy ratings. Nonetheless, our results suggest that in the absence of caregiver or patient data, the general public could be used as proxy to elicit utility data that could be used in decision analytic models comparing treatment options for AD in terms of incremental cost per QALY gained.

5. Conclusions {#sec5}
==============

This study is the first research project using the general public to elicit HRQoL and health utility scores for moderate AD. When utility is captured by the EQ-5D, the general public believes that their utility would decrease by 0.235 if they had moderate AD. This result suggests the


regulator in PDAC by impacting the infiltration of immune cells and thereby regulating tumor aggression [3](#embr201846556-bib-0003){ref-type="ref"}, [5](#embr201846556-bib-0005){ref-type="ref"}, [6](#embr201846556-bib-0006){ref-type="ref"}, [7](#embr201846556-bib-0007){ref-type="ref"}.

The increasing, but still emerging, appreciation that the desmoplastic stroma is not a bystander in pancreatic cancer has underscored the relevance of pancreatic fibrosis as an attractive target for PDAC therapies. Several attempts to target the stroma have been carried out in the past [3](#embr201846556-bib-0003){ref-type="ref"}, [5](#embr201846556-bib-0005){ref-type="ref"}, [8](#embr201846556-bib-0008){ref-type="ref"}, [9](#embr201846556-bib-0009){ref-type="ref"}. A more subtle strategy of reprogramming stromal cells to render them quiescent seems to offer an attractive avenue for adjunct PDAC therapy [4](#embr201846556-bib-0004){ref-type="ref"}, [10](#embr201846556-bib-0010){ref-type="ref"}. Pancreatic stellate cells (PSCs) are the main cell type in the tumor microenvironment and drive the desmoplastic reaction in the pancreas. In the healthy pancreas, PSCs are quiescent, have abundant vitamin A cytoplasmic vesicles, and have low levelsshown to be associated with invasion, metastasis, angiogenesis, lymphangiogenesis, lower overall survival and resistance to chemotherapy in pancreatic cancer [21](#embr201846556-bib-0021){ref-type="ref"}, [22](#embr201846556-bib-0022){ref-type="ref"}, [24](#embr201846556-bib-0024){ref-type="ref"}, [25](#embr201846556-bib-0025){ref-type="ref"}, [26](#embr201846556-bib-0026){ref-type="ref"}. Intriguingly, M2 TAM influx was shown to be significantly correlated with the stiffness of the tumor tissue [27](#embr201846556-bib-0027){ref-type="ref"}. Figure [1](#embr201846556-fig-0001){ref-type="fig"}D shows that the percentage of macrophages (CD68 positive cells) in formalin‐fixed paraffin‐embedded pancreas tissues was reduced upon tamoxifen treatment, which is observed in both 2 mg and 5 mg treatment groups as compared to vehicle‐only controls in a dose‐dependent manner. To further characterize the polarization of tumor‐associated macrophages, we used CD204 macrophage scavenger receptor as marker for the M2 phenotype on freshly frozen PDAC sections from KPC mice [21](#embr201846556-bib-0021){ref-type="ref"}, [22](#embr201846556-bib-0022){ref-type="ref"}. As shown in Fig [1](#embr201846556-fig-0001){ref-type="fig"}E, the percentage of CD204‐positive cells was significantly reduced by increased doses of tamoxifen


between the cell and the ECM and are essential in cell spreading. This prompted us to study whether tamoxifen could affect focal adhesion dynamics in these cells. The number and size of the focal adhesions in tamoxifen‐treated macrophages were significantly decreased compared to control macrophages ([Appendix Fig S2](#embr201846556-sup-0001){ref-type="supplementary-material"}).

![Tamoxifen inhibits spreading, matrix attachment, and invasion in macrophages\
ATime‐elapsed sequential images of macrophages until cells attained maximum area, scale bar is 10 μm.BQuantification of macrophage spreading over time, values represent mean ± s.e.m. *n* = 15 cells per condition (FN, fibronectin).C--EQuantification of cell number ratio, area, and roundness (panels C and E *n* = 30 cells per condition, and numbers are relative to control -- 1 kPa).FRepresentative images of macrophage attachment to 1 and 25 kPa polyacrylamide matrices, scale bar is 50 μm.GRepresentative images of the transwell inserts showing crystal violet‐staineddouble the number of those on the 1 kPa matrix. Furthermore, control cells on the 25 kPa matrix showed a 50% increase in cell area and a 50% decrease in roundness, compared to control cells on the 1 kPa matrix. Interestingly, tamoxifen treatment abolished the sensitivity of cell number, cell area, and roundness to matrix rigidity. For tamoxifen‐treated cells on both 1 and 25 kPa matrices, values for these parameters were equivalent to control macrophages on the 1 kPa matrix.

We then sought to study whether tamoxifen affects the invasive behavior of macrophages *in vitro* using Transwell invasion assays. We observed a significant inhibition of macrophage invasion in the tamoxifen‐treated group with respect to the control cells. Invasion was still inhibited when tamoxifen was used in the presence of the estrogen receptor antagonist. However, inhibition


detect force application and respond to this mechanical tension by rapidly remodeling and stiffening their cytoskeleton (a process known as reinforcement) [32](#embr201846556-bib-0032){ref-type="ref"}. While control PSCs exhibited robust reinforcement to the applied force, as shown by a decrease in the oscillatory amplitude of the bead bound to the cell, tamoxifen‐treated PSCs displayed significantly impaired reinforcement/mechanosensing (Fig [2](#embr201846556-fig-0002){ref-type="fig"}B and C).

![Tamoxifen impairs mechanosensing and force generation via GPER\
ARepresentation of the magnetic tweezers.BRepresentative traces tracking bead displacements.CHistogram shows relative bead displacement for the first and last pulse, *n* = 27 control and *n* = 37 tamoxifen.DQuantification of PSCs stiffness, *n* = 40 control and 38 tam cells.EHistogram shows percentage of gel contraction, *n* \> 10 gels per condition.F, GRepresentative mechanosensing trace of PSC treated with tamoxifen and estrogen receptor (ER) or G protein‐coupled estrogen receptor (GPER) antagonists. Histogram shows relative beadits physiological effect through the classical estrogen receptors alpha and beta (ERα and ERβ), which translocate to the nucleus once activated and act as ligand‐dependent transcription factors [37](#embr201846556-bib-0037){ref-type="ref"}. However, GPER (G protein‐coupled estrogen receptor) from the GPCR family of receptors has been recently shown to modulate the non‐genomic cell responses to estrogen in a broad variety of cell types [11](#embr201846556-bib-0011){ref-type="ref"}, [38](#embr201846556-bib-0038){ref-type="ref"}, [39](#embr201846556-bib-0039){ref-type="ref"}, [40](#embr201846556-bib-0040){ref-type="ref"}, [41](#embr201846556-bib-0041){ref-type="ref"}. We used immunofluorescence and immunoblotting to confirm that PSCs express ERα, ERβ, and GPER ([Appendix Fig S6](#embr201846556-sup-0001){ref-type="supplementary-material"}). To determine which of these specific receptors mediate the biomechanical deactivation of PSCs by tamoxifen, we pre‐treated PSCs with ICI182780 (the commonly used ER antagonist); or G15 (a selective antagonist for GPER), prior to and during tamoxifen treatment, and tested the two properties that promotes the positive feedback


and its localization in PSC nuclei *in vitro* and in mouse models of PDAC.

![Tamoxifen deactivates YAP in PSCs and in pancreatic tissues\
Immunofluorescence images of PSCs stained for YAP. The white arrows show YAP localization in the nucleus. Scale bar: 20 μm.Quantification of the nuclear/cytoplasm YAP in PSCs (four experimental replicates).qPCR mRNA levels for YAP target genes connective tissue grow factor (CTGF) and ankyrin repeat domain 1 (ANRKD1) (three experimental replicates).Western blot bands for YAP, pS127 YAP, and total protein.Quantification of YAP and pYAP Ser127 normalized to total protein, expressed relative to unstimulated control (*n* = 8).IHC images for YAP staining in KPC mice pancreatic tissues (control and treated with 2 and 5 mg tamoxifen), YAP staining is brown. Scale bars: 100 μm.Quantification of YAP‐positive nucleus. *n* = 5 control mice, and ≥ 3 mice for 2 mg andαSMA (PSC marker) and found a similar pronounced 70% reduction of pMLC‐2 in PDAC tissues coming from tamoxifen‐treated mice ([Appendix Fig S13](#embr201846556-sup-0001){ref-type="supplementary-material"}).

![Tamoxifen decreases phosphorylation of mlc‐2 in PSCs and mice pancreatic tissues and suppresses RhoA activation in PSCs\
IF images for total (MLC‐2) and phosphorylated (pMLC‐2) in PSCs, scale bar is 20 μm.Quantification of staining in (A). Each data point represents a cell.Western blot for total and phosphorylated mlc‐2.Quantification of total and active RhoA, expressed as percentage of the total RhoA in the control condition.IHC images for phosphorylated mlc‐2 in mice pancreatic tissues (*n* = 5 control, *n* = 5, 2 mg, and *n* = 3, 5 mg). Scale bars: 100 μm.Quantification of staining in (E).Illustration of the effect of tamoxifen on GPER activation at the cellular level (left panel) and tissue level (right panel). In PSCs, tamoxifen suppresses the


local ethical review committee.

Cell culture and antibodies {#embr201846556-sec-0012}
---------------------------

Primary, culture‐activated human pancreatic stellate cells (passages 6--8, HPaSteC \#3830‐Caltag Medsystems, UK) were exposed to tamoxifen (Tam) dissolved in ethanol at a concentration of 5 μM for 10 days. Medium was changed every 72 h and the drug treatment was performed in subdued light. Tamoxifen (Z‐4‐hydroxytamoxifen) was from Sigma‐Aldrich (H7904). Cells incubated with culture medium (Dulbecco\'s modified Eagle\'s medium---DMEM with 2% FBS, 1% penicillin/streptomycin, and 1% fungizone antimycotic) with an equivalent amount of vehicle (0.1% ethanol) served as controls. AsPC‐1 cells were grown in RPMI 1640 with 10% fetal bovine serum heat inactivated (Gibco, Loughborough, UK), 2 mM [l]{.smallcaps}‐glutamine, 1% penicillin/streptomycin (Sigma‐Aldrich), and 1% fungizone amphotericin B (Gibco, UK). RAW264.7 murine macrophages were maintained in DMEM with 4.5 g/l glucose, [l]{.smallcaps}‐glutamine, 10% fetal bovine serum (FBS;the bead movement (*n* = 27 for PSC Control and *n* = 37 Tam).

Cell compliance {#embr201846556-sec-0015}
---------------

To characterize the mechanical properties of PSCs, we used magnetic tweezers microrheology to measure cell deformation in response to magnetically generated forces. Superparamagnetic 4.5 μm epoxylated beads (Dynabeads, Life Technologies) were coated with fibronectin (40 μg per 8 × 10^7^ beads) and incubated with adherent cells for 30 min, prior to measurements, to allow integrin binding and provide a mechanical link between the bead and the cytoskeleton. The unbound beads were removed by multiple washing with PBS. The experiments were performed at 37°C, 5% CO~2~, and 95% humidity in DMEM containing 2% FΒS in a microscope stage incubation chamber. A viscoelastic creep experiment was conducted by applying mechanical tension onto single beads bound on the apical surface of the cells with a


The final results were calculated for *n* = 3 animals per condition.

Immunohistochemistry {#embr201846556-sec-0019}
--------------------

Formalin‐fixed paraffin‐embedded (FFPE) blocks were sectioned at 4 μm. Deparaffined and rehydrated with histoclear (National diagnostics, HS‐200) followed by decreased concentrations of ethanol, heat‐induced antigen retrieval was done by boiling the sections in 10 mM citrate buffer, pH = 6, for 20 min in microwave (for CD68 sodium citrate buffer, pH = 6, was used). Endogenous hydrogen peroxide activity was quenched with 0.3% H~2~O~2~ in methanol for 30 min at room temperature. Sections were blocked with normal serum for 1 h at room temperature and endogenous biotin activity and avidin binding sites were blocked with avidin--biotin blocking kit according to manufacturer\'s instructions (Vector laboratories, SP‐2001). Sections were then incubated with primary antibodies diluted in blocking serum overnight at 4°C in a humidified chamber. Primary antibody dilutions areof dimension $k-1$ in the Pareto set are related to the subproblems of $k$ objective functions. Such strata play a special role in the optimization process and are fundamental ingredients to decrypt the problem structure when the objective functions themselves are unknown and need to be investigated in order to reveal, in the Darwinian evolution example of section \[sec:evolution\], *how nature works*.

Motivation: Darwinian evolution {#sec:evolution}
===============================

The guiding principle in the Darwinian theory of evolution is often resumed as the “survival of the fittest”. This is often viewed as an optimization principle, suggesting the existence of a hidden fitness function which the living beings are aimed to maximize. The problem comes when the function itself becomes the focus of the interest, because its definition resists to be ultimately discovered. J


truth, it is globalism that only benefits their crony capitalist friends who are adept at pretending to vilify the rich who “do not pay their fair share” while taking the “greedy rich” money to run corrupt political campaigns to continue to keep the poor on the poverty and dependency plantation of globalism. The level of disinformation in the media and in Hollywood has reached an unparalleled crescendo. Back in 1981, Hollywood produced an episode of Barney Miller in which globalism and discussions about it were derided as a conspiracy theory.

Barney Miller was a “sensible” cop. He maintained order over his gambling detectives who chased women, went to “renaissance philosophy conventions for fun,” were aspiring writers, and never seemed to leave the squad room. The show ran from 1975-1982.former U.S. president, mediating on the Ryukyu Islands, although both China and Japan rejected his compromise.

McCartee returned to the United States in 1880, and in 1882 visited Hawaii on business connected with Chinese immigration. In 1885, Dr. McCartee was appointed consul to the Japanese legation in Washington, DC. Two years later the McCartees were reappointed by the Presbyterian Board of Foreign Missions to the Japan Mission, where they served until Dr. McCartee's retirement in 1899. That year he returned to the U.S.A. as an invalid and died in San Francisco the following year.

Divie McCartee devoted nearly forty years of his life to work among the Chinese and Japanese. The Chinese Government gave him a gold medal in recognition of his services in connection with the suppression of the


by retiring David Wright on a fly ball to deep right, starting a string of 10 consecutive outs. He threw 88 pitches, 57 for strikes, while fanning five and walking one before being removed in the sixth for a pinch hitter.

Sunday’s start was the first for the Louisiana native since July 19, 2010, when he dropped a 2-1 decision to the Red Sox as a member of the Oakland A’s. After that game, Sheets was placed on the disabled list for the seventh time in his career. He underwent surgery to repair a torn elbow ligament and, for the second time in two years, a torn flexor tendon. When doctors operated, they confirmed two other problems – a torn ulnar collateral ligament, requiring Tommy John surgery, and damageto the modern world, see some inspiring artwork, eat, drink and navigate the spectacular scenery.

This regular event is held amongst the beautiful scenery of West Gippsland, just one hour from Melbourne. Check out the website for a downloadable map and loads more details on the artists.

The wide range of artisans will give you a choice of styles be excited by - demonstrating their techniques, describing their inspirations and giving you opportunities to buy new work. Has there ever been a more blissful way to spend a lazy day out in the green hills?

With such a diversity of great local artists living the country dream in the region, you are bound to be inspired by all the creativity and beauty West Gippsland has to offer.

Event Dates

2017

25th Mar 26th Mar

Various


   (define rn (random (length s2)))
    (values
     (cons (list-ref s2 rn) s1)
     (append (take s2 rn) (drop s2 (add1 rn))))))

s1 gets initialised to null, s2 to lst. Whenever we add an element to s1 we take it away from s2.

the community with young children who regularly participate in reading programs at the library.

_____________

Overall, the Novel Night was a success, with over 200 guests spread out over the 20 homes.

____________

In keeping with a Jersey ambiance, a full-size craps gaming table and two dealers provided amusement in the living room. Food and beverages included staples from various local Italian restaurants along with a sommelier pouring Italian wines.

Jersey style

Novel Night, which is sponsored by Friends of the Hoboken Public library and co-sponsored by the Hudson Reporter, allows 20 hosts to coordinate their homes and meals to different book themes. Attendees pick their experiences ahead of time, and are then invited to discuss the book and enjoy the dinner. While most dinners typically seat 10 to 12 guests, “The Jersey Sting”


the most important variable may be the volume of the core occupied by the strong field (see below) rather than simply its strength. Thus we keep an open mind with respect to present observations.

Independent of observation, it is important to estimate parity violating effects. We see three possibilities: parity violating effects could be small and thus irrelevant, they could be large and observed or they could be potentially large and not observed. If they are not observed, it may still be possible to set useful limits on the magnetic field configuration or on new weak interactions. In any case, we need accurate theoretical estimates.

Previous estimates of parity violation may be incomplete because they ignore possible enhancements from repeated interactions. Neutrino transport involves diffusion with neutrinos undergoing many parityQ:

How to disable fancy visual effects in Gnome Shell?

I there!
I'm a new Ubuntu user and I began with version 11.10. I recently installed Gnome Shell (gnome-shell package in Ubuntu Software Center) after running with Ubuntu 2D. I thought it would be faster but indeed not really (mainly) because (I guess) all the fancy visual effects. However, I really love the interface and so would like to keep running with GNOME Shell (not GNOME Classic).
How/Where can I disable all those fancy visual effects in order to work with the lightest interface I can?
Thanks!

A:

The extension 'Disable Window Animation' don't work any more in Gnome 3.8, so just do this command to disable it:
gsettings set org.gnome.desktop.interface enable-animations false


accommodate facilities for field games. At this time organised games revolving around fair play and emphasising teamwork were included as part of the broader themes of educational philosophy. In order to accommodate such changes, the Department of Public Instruction began to purchase sites which allowed adequate space to be dedicated to physical education. Stafford State School had two full playing ovals accommodating football, cricket, basketball, vigaro, hockey and athletics, with a swimming pool and grandstand complex added later.

The building was designed by Frederick Thomas Wylie Warren of the Architectural Branch of the Queensland Department of Public Works and construction of the first stage was completed in 1948. A second stage was completed in 1955 from the original design. The form and architectural style of building is more typicalthe unit sphere $\mathbb{S}^n$ by $\omega_n$ and we shall denote the volume of the unit ball $\mathbb{B}^n$ by $\kappa_n.$

Cauchy’s formula
================

Let $K$ be a convex body in $\mathbb{E}^n.$ Let $u \in \mathbb{S}^{n-1}$ be a unit vector, and let us define $V_u(K)$ to be the (unsigned) $n-1$-dimensional volume of the orthogonal projection of $K$ in the direction $U.$ *Cauchy’s formula* (see [@santalo Chapter 13]) then states that $$\label{cauchy}
\boxed{V_{n-1}(\partial K) = \dfrac{n-1}{\omega_{n-2}}
\int_{\mathbb{S}^{n-1}}V_u(K)\,d\sigma = \\
(n-1)\dfrac{\omega_{n-1}}{\omega_{n-2}} \fint_{\mathbb{S}^{n-1}}
  V_u(K)\,d\sigma,}$$ where $d\sigma$ denotes the standard area element on the unit sphere.

In the case where $K=E$ is an ellipsoid, given by $$E = \{\mathbf{x}\in \mathbb{E}^n \quad | \quad \sum_{i=1}^n q_i^2 x_i^2 = \leq
1\}$$ the volume $V_u$ of the projection is computed in Example \[dimn1\] as a special case of more general projection results: $$\label{conform}
V_u(E) =


who have lost their pensions with a pension equivalent to the annuity that would have been received had the pensions contributions made by the employee, and a matching contribution by his employer, been invested in a typical money purchase scheme instead of the actual final-salary scheme. Anything above that is the responsibility of those who egged on employees to demand unrealistic final-salary schemes that could in many cases be funded only by forcing the employer into insolvency.

I have been playing around with some figures over Easter (Yes I know that’s pretty sad!). If a person started on a salary of £20,000 40 years ago and his salary increased by say 5% pa. throughout the period he would today be earning £140,780 pa. A two-thirds pension would therefore beof the Public Trustees Act 1906 to act as custodian trustee. Where a trust is exported it would be very unusual to apply to the Courts to appoint the offshore trustee, so in practice a company needs to meet the Public Trustee Act definition, which is contained in Rule 30 of the Public Trustee Rules 1912. This requires a trust corporation, amongst other things, to be incorporated in the UK or an EC Member State. An offshore company cannot meet this test. Therefore IBI is not a trust corporation – and nor is any other tax haven company likely to be one either.

The Defendant in the Jasmine Trustees case sought to claim that IBI is an “individual” for the purpose of the rules, but this was dismissed by


Mr Justice Mann.

Accordingly section 37(1)(c) prohibited Major-General and Mrs Coaker from resigning. They were therefore still trustees. Major-General Coaker died in 1983 and Mr Thornton died in 1989. Mrs Coaker died in 1996. IBI resigned in 1987.

Where did this leave the trust? Answer: without any trustees. Worse, because trustees must act unanimously except where the trust deed specifies otherwise, and Mrs Coaker was not involved in any decisions made since her purported resignation, all such decisions – in particular the subsequent decisions to appoint different trustees on a number of occasions - were invalid. This meant that none of the subsequent trustees were trustees of the settlement (although they had the liabilities of trustees for having meddled with the trust assets).

It followed from this that at no timeloss account, on the other hand, is concerned with revenue and costs, and in that context, the figure for stock represents a cost which SSAP 9 requires to be kept out of the computation of profit for the year but recorded to be carried over into the computation for a future year”.


---
abstract: 'We use polyhedral product models to analyse the structure of the commutator subgroup of a right-angled Artin group. In particular, we provide a minimal set of generators for the commutator subgroup, consisting of special iterated commutators of canonical generators.'
address:
- 'Department of Mathematics and Mechanics, Moscow State University, Leninskie Gory, 119991 Moscow, Russia, Institute for Theoretical and Experimental Physics, Moscow, Russia *and* Institute for Information Transmission Problems, Russian Academy of Sciences'
- 'Steklov Mathematical Institute, Russian Academy of Sciences'
author:
- Taras Panov
- Yakov Veryovkin
title: 'On the commutator subgroup of a right-angled Artin group'
---

[^1]

Introduction
============

A *right-angled Artin group*, also known as a *graph group*, has $m$ generators $g_1,\ldots,g_m$ and commutativity relations $g_ig_j=g_jg_i$ for some pairs $\{i,j\}$. Such a group interpolates between the free group of rank $m$ (in which no pair of generatorsthis form one by one from the left. Denote by $|{\varphi}|$ the number of alterations of $g_1$ and $g_2$ in the word ${\varphi}$. Note that if $|{\varphi}| {\leqslant}2$, then ${\varphi}= 1$, as ${\varphi}\in F_2'$. We induct on the number $|{\varphi}|$. Assume that ${\varphi}= g_1^i g_2^j g_1 \psi$ (the case ${\varphi}= g_2^i g_1^j g_2 \psi$ is considered similarly). We rewrite the word as follows: ${\varphi}= g_1^i g_2^j g_1^{-i} g_2^{-j} g_2^j g_1^i g_1\psi = (g_2^{-j}, g_1^{-i}){\vphantom{A}}^{-1}g_2^j g_1^{i+1}
\psi$. Now $\varphi$ is the product of a commutator of the required form and the word ${\varphi}_1 = g_2^j g_1^{i+1} \psi$, where $|{\varphi}_1| <|{\varphi}|$. Therefore, after finitely many iterations we arrive at a word ${\varphi}_k$ with $|{\varphi}_k| {\leqslant}2$, i.e. ${\varphi}_k = 1$.

*Case $m = 3$.* Let $F_3 = F(g_1, g_2, g_3)$. We need to check that


is not chordal, so the group $\raag'_\sK$ is not free. In fact, $\raag'_\sK$ contains a surface group of genus $5$, generated by the ten commutators above with all exponents $n_i=1$, which satisfy a single relation. This surface group is the commutator subgroup for the right-angled Coxeter group corresponding to $\sK$, see [@pa-ve16 Example 4.8].

**2.** Now let $\sK$ be the $1$-dimensional simplicial complex (graph) shown in Figure \[pentagon\], right. This graph is chordal, so the corresponding group $\raag'_\sK$ is free. Theorem \[raagbasis\] gives a basis consisting of the commutators $$\begin{gathered}
  (g_3^{n_3},g_1^{n_1}),\;(g_4^{n_4},g_1^{n_1}),\;(g_5^{n_5},g_3^{n_3}),\;
  (g_1^{n_1},(g_5^{n_5},g_3^{n_3}),\;(g_3^{n_3},(g_4^{n_4},g_1^{n_1})\end{gathered}$$ with $n_k \in \mathbb{Z}\setminus\{0\}$.

Generalisation to graph products {#secgp}
================================

Let $\sK$ be a simplicial complex on $[m]$ and let ${{\textbf {\textitG}}}=(G_1,\ldots,G_m)$ be a sequence of $m$ groups. The graph product ${{\textbf {\textitG}}}^{\sK}$ is defined as the quotient group $${{\textbf {\textitG}}}^{\sK}\cong\mathop{\mbox{\Huge$\star$}}_{k=1}^m G_k\big/(g_ig_j=g_jg_i\,\text{ for
}g_i\in G_i,\,g_j\in G_j,\,\{i,j\}\in\sK),$$ where $\mathop{\mbox{\Huge$\star$}}_{k=1}^m                          ^------------- delete this

Why? Because it declares an empty statement, so the for body will be empty. Therefore when you try to use variable i, it is actually out of the block it was declared in (a block is delimited by { }).


using System.Resources;
using System.Reflection;

[assembly: AssemblyTitle("XamlAnimatedGif")]
[assembly: AssemblyDescription("")]
[assembly: AssemblyConfiguration("")]
[assembly: AssemblyCompany("Thomas Levesque")]
[assembly: AssemblyProduct("XamlAnimatedGif.WinRT")]
[assembly: AssemblyCopyright("Copyright © Thomas Levesque 2014")]
[assembly: AssemblyTrademark("")]
[assembly: AssemblyCulture("")]
[assembly: NeutralResourcesLanguage("en")]
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Forget about those shoes that are half-off and the latest and greatest video game console — #GivingTuesday is a breath of fresh air after your frenetic holiday search for the perfect buy. Now in its second year, #GivingTuesday was created as an antidote to the shopping frenzy that comes with Black Friday and Cyber Monday. Rally.org is partnering with #GivingTuesday to showcase a collection of non-profit organizations that are tirelessly working to improve living conditions, create cures and rebuild lives. (more…)Q:

PostgreSQL find groups with same members

Given the following schema:
User
  id

Group
  id

Membership
  group_id
  user_id

(With a unique index on group_id, user_id)

How would I select the group(s) of which the same two users are a member?
What I have now:
SELECT   "Membership"."group_id"
FROM     "Membership"
WHERE    "Membership"."user_id" IN (1, 2)
GROUP BY "Membership"."group_id"
HAVING   COUNT("Membership"."group_id") >= 2

Which seems to work, (it only retuns the group ids of which both users are a member), but looks rather confusing.
Is there a better way to express this query?
EDIT
So given the following data:
Users
-----
id
1
2
3

Group
-----
id
1
2
3

Membership
----------
group_id user_id
1        1
1        2
2        1
2