hard but rewarding and encountered both practical and intangible obstacles to participation. Members received varying types of practical support, but a supportive collegial milieu was characteristic among members who felt most confident about their participation. The milieu, structures, and processes of advisory bodies must all be adjusted to accommodate people with intellectual disability if they are to participate meaningfully.this provision meaningless. See Schaefer, 124 S.W.3d at 159 (contracts should be interpreted to avoid rendering a provision meaningless). We conclude both of these interpretations of the decree are reasonable, and thus we find the decree is ambiguous as to the exact nature of the oil and gas interests awarded to Broesche in the decree. See Zurich, 157 S.W.3d at 467 (conflicting yet reasonable interpretations renders a contract ambiguous). Therefore, we conclude the trial court erred in finding that the decree unambiguously awarded Broesche an interest only in the wells and not in any leaseholds. We sustain Broesche's first issue.[4]

*274 B. Conversion Claims
In 2002, Broesche began demanding that TIE release to her the oil and gas revenues that TIE had been holding in suspense since Jacobson filed the


summary judgment and the court grants one but denies the other, the losing party cannot appeal the denial of its motion without also appealing the granting of the other party's motion. See CU Lloyd's of Tex. v. Feldman, 977 S.W.2d 568, 569 (Tex.1998) (noting that denial of summary judgment was appealable because appellant appealed ruling granting other party's motion); Bullacher v. First Republic Bank, No. C14-89-00015-CV, 1990 WL 4230, at *1 (Tex.App.-Houston [14th Dist.] Jan. 18, 1990, writ denied) (not designated for publication) (refusing to consider arguments regarding denial of appellants' summary judgment motion because appellants did not challenge trial court's grant of appellees' summary judgment motion). Broesche's brief never mentions, much less rebuts, the specific grounds for summary judgment on her conversion claim against TIE offered inJacobson's motion. After a hearing in April 2003, the court carried Jacobson's motion but granted TIE's motion and ordered Broesche to pay TIE $17,500 in sanctions. The trial court issued this order on June 17, 2003. After the pretrial hearing in which the court construed the divorce decree against Broesche, the trial court held another sanctions hearing and, in an order dated February 24, 2004, granted Jacobson's motion for sanctions and ordered Broesche to pay Jacobson $162,000.
In her seventh and eighth issues, Broesche alleges the trial court abused its discretion in imposing sanctions. She neither disputes the trial court's method of calculating the amount of sanctions, which was based on unnecessary attorneys' fees expended in response to the sanctionable conduct, nor claims the overall amount of sanctions imposed


at 512-13, 2006 WL 2548232, at *8; Vela v. Wagner & Brown, Ltd., 203 S.W.3d 37, 62 (Tex.App.-San Antonio 2006, no *277 pet.). The trial court did not abuse its discretion in determining Broesche should be sanctioned for this conduct, even if the conduct did not violate a specific rule or statute.
The trial court awarded sanctions based not only on these three incidents but on a host of other misconduct. In assessing sanctions, the trial court is entitled to consider the entire course of the litigation. See Clark, 217 S.W.3d at 512-13, 2006 WL 2548232, at *8; see also Downer v. Aquamarine Operators, Inc., 701 S.W.2d 238, 241 (Tex.1985) (noting the presumption in sanctions proceedings that the trial court is familiar with the entire case). Based on thebe important to determine whether aging induces epigenetic changes in monocyte/macrophage progenitors and/or tissue macrophages that maintain macrophage populations through self-renewal, and to test whether such epigenetic alterations modulate macrophage function. Because macrophages are so susceptible to environmental cues, it will be important to examine the interplay between cell autonomous and externally driven mechanisms to elucidate age-associated changes in macrophages. In future studies, it will also be important to assess the causative link between age-related alterations in the function of macrophages and the onset and progression of chronic inflammatory diseases.

Perspectives
============

As we have summarized here, age-related changes in immunity are characterized by both impairment of adaptive immunity and activation of low-grade chronic inflammation. The paradoxical activation of chronic inflammatory states very likely contributes to the progression of age-associated diseases.


improper tissue remodeling (e.g., extensive fibrosis) may impair tissue function and result in the generation of endogenous proinflammatory stimuli such as extracellular matrix molecules and their degradation products (matrikines).^[@bib4]^ Macrophages are crucially involved in all these processes, which impair the proper resolution of inflammation. As such, a better understanding of the changes in macrophage function, phenotype and epigenome that occur with aging will not only shed a new light on inflammaging, but also lead to identification of new therapeutic targets for the treatment of age-associated ailments.

This study was supported in part by MEXT KAKENHI Grant Numbers 26461142-0 and 25H10 (to Y.O.), and 15H01506 and 16H05295 (to I.M.); AMED-CREST (to I.M.).

The authors declare no conflict of interest.

![Aberrant inflammatory response of a dendritic cell and macrophage with aging. Toll-like receptorsout over the course of an hour and a half in time, and it's a pretty solid reminder of how good of an actor Depp is, as well as why we're in dire need of another real-time thriller at the movies.

Insomnia

As prolific as Christopher Nolan is, Insomnia continues to be one of his constantly overlooked entries in his canon. With Al Pacino losing his mind, due to Robin Williams' taunts and the fact that he's in Alaska during the time of year where the sun doesn't go down, Nolan weaves his trademark blend of cerebral thrills and chills in his last film before Batman Begins shot him into the stratosphere. After watching Insomnia, it's no mystery why Nolan got the DC Comics gig.

Deep Impact

In case you haven't noticed,


this action classic is much less rosy about how television has progressed, as the titular game show is a dastardly tool used to pacify the masses and punish those that find themselves unlucky enough to be selected. It's classic Arnold, and if we do say so ourselves, it's one of our top 5 films from the man's extensive resume.and restaurants at each end of the main station house. Beginning in the mid-1930s, the CB&Q introduced their famous Zephyr trains this depot became a station on several of the trains, including the Nebraska Zephyr, Ak-Sar-Ben Zephyr and Denver Zephyr. It was also a station on the Exposition Flyer, operated jointly between the CB&Q, Denver & Rio Grande Western and Western Pacific railroads between Chicago and Oakland, a train which would later be replaced by the famed California Zephyr. The depot eventually would serve Burlington Northern trains between 1970 and 1971 and later Amtrak trains post 1971. By the early 1980s, however, Burlington Northern officials began to question the necessity and practicality of having such a large depot in the face of declining passenger service. Following a study


has and to help others in need,” Daly said. “We want to tell our friends about the great work TOMS does and how they can be a part of putting shoes on the feet of impoverished kids.

“But that's not our choice. By contract, TOMS has the right to block broadcast of the program. We hope they won't do that, but we have yet to hear directly from Blake or anyone at TOMS about this situation.”

Daly admitted he was “a little saddened” by the vitriolic response of those whose protests led Mycoskie to distance himself from Focus.

“This is an unfortunate statement about the culture we live in, when an organization like ours is deemed unfit to help children in need simply because we hold to biblical beliefs about marriagethe DCCT was that the frequency of hypoglycaemia was three-fold higher in the well-controlled patients than those with ordinary control. This confirms the long-standing appreciation by physicians that hypoglycaemia is extremely frequent in IDDM, and especially so in those that are well controlled. There are many reasons for this including mistiming of insulin injections and food, erratic absorption of insulin, and impaired secretion in some diabetic patients of the so-called counter regulatory hormones such as adrenaline and glucagon that oppose the action of insulin.
About one third of IDDM patients have no warning symptoms of hypoglycaemia (eg sweating, nausea, blurred vision, palpitations) and they rely on intermittent self-monitoring of blood glucose to detect dangerously low glucose levels. The consequences of hypoglycaemia include impaired cognition and consciousness, and eventually coma.
Since


a static component in human blood, changes in blood glucose concentration following food intake in normal and hyperglycaemic conditions are reasonably predictable. Similarly, the variation in glucose concentration as blood passes from arteries or capillaries to veins has also been documented. Therefore, over time, repeated measurement of blood glucose from the same patient may diverge widely. Also, blood obtained simultaneously by finger stick and venipuncture may not have the same glucose concentration. (Venous blood may contain 1 mmol/I less glucose than capillary blood if the same samples are obtained within 1-2 hours after carbohydrate intake).
Furthermore, the haematocrit of the patient (the volume of cells, mostly erythrocytes, expressed as a percentage of the volume of whole blood in a sample) influences glucose values, and whole blood glucose measurements mustaccount if I already have one?

No, in order to use eCatholic Payments, you'll need to set up a new merchant account through our partnership with CardConnect. Don't worry, it's quick and simple and part of the sign up process for eCatholic Payments.

How quickly does my money get deposited in our bank account?

Payments made via credit and debit cards are typically deposited into your bank account within 48 hours. Payments made via eCheck (bank account transfers) usually take about 5-6 days to be deposited into your bank account.

Can we use a card reader with a mobile device with eCatholic Payments?

CardConnect, our merchant account partner, offers a mobile card reader that can be used with tablets and smartphones. For more information, give us a call.

Security Questions

Are transactions on my website


and we'll be there to lend a hand!

Still have questions? Let's chat!

Have a question we didn't cover here? You're not at the end of the rope yet. Our team is here to help (with a smile).Service, and the Bureau of Alcohol, Tobacco, Firearms and Explosives.

The charges in an indictment are merely accusations, and a defendant is presumed innocent until and unless proven guilty in a court of law.

END


view('welcome', ['form' => $form]);
        }
        //main login (index page)
        public function postLogin(Request $request){
            //validation
            $this->validate($request,[
                'email' => 'required|email',
                'pass' => 'required'
            ]);
            //authintecating user
          return redirect()->route('index')->with(['fail'=>'Wrong Email or Password!']);
        }
        public function getHome(){
            return view('home');
        }
}

why does the browser gives me an error?

A:

Try changing:
Route::get('/{form?}', [
'uses' => 'UserController@getIndex',
'as' => 'index'
]);

To:
Route::get('/form/{form?}', [
'uses' => 'UserController@getIndex',
'as' => 'index'
]);

I believe when you go to the '/' route, the '/{form?}' route is being executed.


Q:

Are github release notes store on git?

The release notes seem like a great thing to me but I'm wondering if they are stored on git or just an external storage system which github owns.

A:

Apparently not: a release seems to be proprietary to GitHub and not a metadata attached to your Git repo (using git notes for examples).
At the time of this feature (Release Your Software, July 2013), the blog post "About Github's New Releases Feature" noted:

However, there's something that still bothers me. It's tightly coupled into Github which only allows us to enter the information into Github's Releases system.
  We can't transfer the data together with our Github repo if we decide to move the project from Github.
  We also can't versionize or collaborate on theare changing," lead singer Mick Jagger said in Spanish to a roar from the crowd.

Dave J Hogan via Getty Images

Mick Jagger spoke in Spanish throughout of the 18-song show of hits that lasted more than two hours.

The singer spoke in Spanish throughout of the 18-song show of hits that lasted more than two hours. The band played "Sympathy for the Devil" as a yellow moon rose through clouds, and they finished a two-song encore with "Satisfaction."

Fans started gathering 18 hours ahead of time at Havana's Sports City football and baseball fields, including Cubans who traveled from across the Caribbean's largest island and foreigners who flew in for the occasion.

While no official estimate was immediately available for the crowd size, Cuban state media estimated half a million people could


of the
open windows at the same time in a grid view.

~~~
GHFigs
_There’s also a thumbnail view that shows all your open pages in a grid, to
let you quickly move from one page to the next._ \--
<http://www.apple.com/ipad/features/>

   "program_title": "cardio demo"
}

But I want a shallow copy of The object like
Expected Response:
{
    "id":1,
    "category": "cardio",
    "description": "exercies for cardio",
    "price": "50",
    "program_title": "cardio demo"
}

I tried changing CascadeType but it would stop showing nested objects in all APIs, I only want the nested objects to be removed when I call findAll() method.
Is there a way to stop showing nested objects when I call the findAll() method?

A:

I see two choices:

If you want to avoid serializing the fetched fields, use @JsonIgnore.
If you don't want to fetch those fields at all, create a DTO and write a custom query to map the results to it:
public class ProgramDTO {

    private Long


previously been reluctant to allow larger structures on the site, decided to change course because of the colder weather.

"The Metropolitan Urban Indian Directors asked us if they could put warming huts up. And we have agreed that warmth in this moment is a need. We've asked them to work with our fire chief to make sure that [it] is also safe. Public safety is a big concern," said Nuria Rivera-Vandermyde, Minneapolis city coordinator.

The large green army tents will be heated with wood burning stoves. Max Nesterak | MPR News

The city was previously reluctant to allow substantial investment at the current site because they still want to encourage people to seek traditional shelter, Rivera-Vandermyde says. That's an unpopular option among people at the encampment who say shelters don't feelthat megalithic monuments including Stonehenge may have incorporated important astronomical alignments.

Hunting aids
The desert kites of Syria, Jordan, and the Negev—long lines of stones—are interpreted as aids to hunting large game animals like gazelles, ibexes, wild asses. There are similar structures on most continents.

Navigation aids
The inuksuit of the Arctic act as navigation aids, an aid for hunting, or to mark important locations. The rock marker helped the traveler or hunter to find the best route across the land. Someone left a marker to help anyone else passing through the area, and to help with not getting lost. These markers can have very practical and universal purposes. Some petroforms are located along portage routes and canoe routes as well.  Human made markers can be easier to remember than common


Jordan drivers held in Iraq freed

Iraqi authorities have released four Jordanian drivers detained in Baghdad for 17 days on suspicion of being fighters opposed to the presence of foreign troops in Iraq, one of the released Jordanians said.

13 May 2005 12:21 GMT

The truck drivers were accused of being fighters

Mohammed Yassin Freiwan, 25, said he and three other drivers had worked for an Iraqi car dealer for two years and never had problems until they were arrested on 25 April when they were looking for a hotel.

"For 17 days, we were questioned continuously by the Iraqi police whether we had anything to do with Abu Musab al-Zarqawi and the insurgency," Freiwan said in Baghdad.

An Iraqi official and Jordanian lawmaker Nariman al-Rossan confirmed the detention of the four drivers, whohave ever traveled beyond low-Earth orbit, the long-term effects of radiation exposure outside the planet’s magnetic field are still largely unknown. NASA guidelines estimate that males should spend at most 268 days in space and females at most 159 days in space to remain below a three percent chance of contracting cancer over their lifetime. A potential Mars mission would take at least 520 days round-trip, during which a dangerous solar flare could occur. Major solar storms have been relatively rare during the last century, though this may not be the case in the future. Data from polar ice indicate that we are living through a relatively mild period of solar activity, which may pick up and cause storms larger than even the largest recorded episode – the


serious ailment known as silicosis, which once created one of the biggest occupational hazards in U.S. history after dry drilling in a mine in West Virginia killed hundreds of miners during the Great Depression. Finely ground quartz particles are liable to enter the lungs, where coughing does little to dislodge them. The body’s natural antibodies, white blood cells, die when they try to clean up the dust. The reduced gravity on the moon means that dust may float more, be easier to inhale, and stay in the lungs longer. After lunar dust got into the Apollo cabin in 1972, astronaut Harrison Schmitt felt congested and complained of “lunar dust hay fever.” Over long periods, the dust is suspected of acting like asbestos fibers, increasing the risk of cancerresults of this study suggest that in the prehospital setting more liberal use of supplemental oxygen even for those with an SpO~2~ between 92--94% may be warranted.

Traditionally the costs of pulse oximetry were thought to be unaffordable, but recent evidence may suggest otherwise. Several pulse oximeters have been shown to be cost-effective\[[@pone.0230911.ref031]\], accurate\[[@pone.0230911.ref032]\], and validated in low resource settings.\[[@pone.0230911.ref033]\] This is the first study to comment on its use in prehospital systems in a LMIC. Given the relationship between hypoxemia and mortality, pulse oximetry could be incorporated into health system strengthening efforts in LMICs. Specifically, pulse oximetry should be included into protocols for prehospital triage and care---developing diversion systems for sick children to bypass lower level facilities and proceed directly to higher levels of care---and in optimizing interfacility


referrals. Ensuring facility and ambulance-based providers are measuring oxygen saturation consistently is an important quality of care metric.

National recommendations and IMCI protocols are available throughout India to aid in the decision to transfer children to a higher level of care, but data specific to their use are lacking.\[[@pone.0230911.ref013],[@pone.0230911.ref034]\] Furthermore, access to and capacity management at pediatric specialty centers is not well coordinated and ambulance diversion protocols to these centers in India is not always clear. In this study the majority of IFTs were to district hospitals and medical colleges, however 12% were transferred to PHCs and CHCs, lower level facilities.

Across several indicators, including mortality, IFTs represented a more ill cohort, as compared to field transports. Even in countries with mature systems, patients are at increased risk of morbidityAs part of the continued investment in providing 3 000 young, unemployed South Africans with in-demand technology and business skills, CapaCiTi is launching a programme to teach candidates to code with Java.

CapaCiTi is a full-time tech career accelerator for local youth who are keen on acquiring tech skills. The programme is one of several offered under the umbrella body CiTi (Cape Innovation and Technology Initiative).

CiTi head of programme Soraya Mohideen says the Java Launch training and placement programme will run in Cape Town and Johannesburg in September.

"The Java Launch CapaCiTi programme will teach students to code with Java, but also the broader technical and business knowledge needed to succeed in today's workplace. During the programme, students will learn the fundamentals of Java, one of the most in-demand and


limit for NT-proBNP but not for simultaneously measured BNP. A history of gastric bypass surgery appeared to be a significant predictor of increased natriuretic peptide concentrations when assessed in a population of patients with class 2 or 3 obesity.boat belonging to private US company Ocean Infinity, which found the Minerve at a depth of 2,370 metres (7,800 feet), a senior French naval officer told AFP.

The search vessel -- the Seabed Constructor, which is equipped with underwater drones with powerful cameras -- arrived on the scene last Tuesday, the officer said on condition of anonymity.

The Seabed Constructor was also successful in locating Argentina's lost San Juan submarine in November 2018 which disappeared in the Atlantic Ocean a year earlier.

- Naval mystery -

The cause of the loss of the Minerve has never been confirmed but the news that it has been found fought joy and relief to families.

"I can't find the words to describe my emotion," the wife of one of the lost sailors, Therese Scheirmann-Descamps, told AFP


Introduction
============

Turnover is a critical issue for the nursing workforce[@B1], negatively affecting the health system regarding both disease prevention and the health and quality of the nursing services[@B2]. The shortage of nurses is a global problem[@B3] and the turnover of nurses is very high in comparison to other healthcare professions[@B4]. The Council of Europe has estimated that the nursing workforce will face a shortfall of 590,000 people by the year 2020 and the intention to leave the nursing profession varies from 4% to 54% of nurses surveyed[@B5]. In addition, almost 72% of nurses have thoughts of leaving the nursing profession everyday[@B6]. In Iran, official figures on the shortage of nurses are not available, however, with a population of 75 million in 2013, it is considered that approximately 240,000 nursesare needed to service this size of population, whereas there are currently only 100,000 nurses. Even by doubling that number, the population would still have minimal access to health care[@B7]. In other studies with Iranian nurses the levels of intent to leave nursing are high[@B8] and only one third of nurses (34%) reported satisfaction with their jobs[@B9]. Lack of job satisfaction is likely to have a direct impact on the intent to leave the career. Given the current shortage of nurses in the country, and considering the severe shortage of nurses expected in the future due to the retirement of existing nurses, population growth, and an aging population profile[@B10], it is of extreme importance to assess the extent of this problem in Iran.

A shortage of nurses and high


and studies the conditions influencing this. It is hoped that by understanding these processes, the relevant authorities will be able to formulate a strategy to retain nurses within the clinical practice. The aim of this study was to explore the developmental process of the generation of a desire to leave bedside nursing.

Method
======

The nurses who participated in this study were selected from several teaching hospitals affiliated to Tabriz and Urmia Universities of Medical Sciences in Iran. The sample selection process was based on the following criteria: 1) having a high school diploma or higher, 2) having at least one year of work experience in the clinical nursing practice, and 3) acceptance of the invitation to participate in the study. A total of 21 nurses employed in different wards ofa governmental teaching hospital met the inclusion criteria and agreed to participate in the study.

Selection of the participants was initiated using purposive sampling and after the eighth interview continued through theoretical sampling (In order to complete the categories and concepts created from previous interviews) until saturation was achieved.

The study subjects took part in semi-structured interviews in which open-ended questions were used to investigate the process of the development of the intention to leave the profession in experienced nurses working in a clinical setting between May 2014 and July 2015, (over a period of 14 months). Researchers interviewed each participant individually for 40 to 60 minutes in the work place (n=16), and outside (n=5). The interview began with the general question \"how would you describe your experience of the


work environments of nurses are changed by educational, political, economic and social conditions and expectations of healthcare. It is important therefore to consider the utilization of a longitudinal study to investigate the effects of various changes on the perceptions of nurses regarding their work environment and job.

Relevance to clinical practice
==============================

The majority of nurses who want to leave the profession are young, of high-quality and in search of new challenges. To keep this category of nurses in the profession, it is necessary to provide new challenges and possibilities for their professional development. This can be accomplished by improving the working conditions and by enhancing the standing of the profession within society, both of which could contribute to higher levels of motivation.

Conclusion
==========

The findings of this study provide useful information about2012–13 UNC Wilmington Seahawks men's basketball team

The 2012–13 UNC Wilmington Seahawks men's basketball team represented the University of North Carolina Wilmington during the 2012–13 NCAA Division I men's basketball season. The Seahawks, led by third year head coach Buzz Peterson, played their home games at the Trask Coliseum and were members of the Colonial Athletic Association. Due to low APR scores, the Seahawks were ineligible for post season play, including the CAA Tournament. They finished the season 10–20, 5–13 in CAA play to finish in ninth place.

Roster

Schedule

|-
!colspan=9| Exhibition

|-
!colspan=9| Regular Season

References

Category:UNC Wilmington Seahawks men's basketball seasons
UNC Wilmington


who writes pretty much the way he speaks

Now Cneifiwr: please - don't you have far right groups in Wales too? I think this is a regrettable tendency not exclusive to the evil English.

And I'm not sure about you all looking like typical M&S customers: why is the gentleman on the left wearing regency style breeches? Is this fashion still in Carmarthen? Tell him to nip inside and buy a nice pair of machine washable, non iron polyester trousers and smarten himself up.

Perhaps you might encourage the Welsh speaking men of Carmarthenshire to adopt a pants free protest, and go commando until M&S withdraw their Welsh language embargo?

Just a thought. Hold on: still thinking about it ...

But seriously, good luck with your protests, and I would be doing exactly     LineHeightMultiple
       NSParagraphStyle
(CGFloat)

       BaseWritingDirection
       NSParagraphStyle
(NSWritingDirection)

       DefaultTabInterval
 TabStops
       NSParagraphStyle
CGFloat/NSArray(NSTextTab)

Usage
==============

### Basic
    // YYLabel (similar to UILabel)
    YYLabel *label = [YYLabel new];
    label.frame = ...
    label.font = ...
    label.textColor = ...


highlight with your custom config:

    // 1. Create a 'highlight' attribute for text.
    YYTextBorder *border = [YYTextBorder borderWithFillColor:[UIColor grayColor] cornerRadius:3];

    YYTextHighlight *highlight = [YYTextHighlight new];
    [highlight setColor:[UIColor whiteColor]];
    [highlight setBackgroundBorder:highlightBorder];
    highlight.tapAction = ^(UIView *containerView, NSAttributedString *text, NSRange range, CGRect rect) {
      NSLog(@"tap text range:...");
      // you can also set the action handler to YYLabel or YYTextView.
    };

    // 2. Add 'highlight' attribute to a range of text.
    [attributedText yy_setTextHighlight:highlight range:highlightRange];

   // 3. Set text to label or text view.
    YYLabel *label = ...
    label.attributedText = attributedText

    YYTextView *textView = ...
    textView.attributedText = ...

    // 4. Receive user interactive action.
    label.highlightTapAction = ^(UIView *containerView, NSAttributedString *text, NSRange range, CGRect rect) {
        NSLog(@"tap text range:...");
    };
    label.highlightLongPressAction = ^(UIView *containerView, NSAttributedString *text, NSRange range, CGRect rect) {
        NSLog(@"long press text range:...");
    };

    @UITextViewDelegate
    - (void)textView:(YYTextView *)textView didTapHighlight:(YYTextHighlight *)highlight


YYLabel 或 YYTextView
    YYLabel *label = ...
    label.attributedText = attributedText

    YYTextView *textView = ...
    textView.attributedText = ...

    // 4. 接受事件回调
    label.highlightTapAction = ^(UIView *containerView, NSAttributedString *text, NSRange range, CGRect rect) {
        NSLog(@"tap text range:...");
    };
    label.highlightLongPressAction = ^(UIView *containerView, NSAttributedString *text, NSRange range, CGRect rect) {
        NSLog(@"long press text range:...");
    };

    @UITextViewDelegate
    - (void)textView:(YYTextView *)textView didTapHighlight:(YYTextHighlight *)highlight inRange:(NSRange)characterRange rect:(CGRect)rect {
        NSLog(@"tap textto acceptable broadcasting standards. If there is a risk that the broadcaster lacks that commitment, then standards are constantly in peril. And in this case, that would be enough to block the bid. The case for referral is overwhelming, based on the record of Fox News as well as the total failure of corporate governance in the Murdoch empire revealed by what happened at the News of the World and at Fox. The secretary of state must have a proper inquiry into these dangers. If she does not and we end up with Sky becoming more like Fox, it will be her responsibility.

The onus is not just on Bradley. Soon Ofcom is due to reply to a legal threat by Avaaz, and a detailed submission from Ken Clarke,


do this.

~~~
unalone
> What I meant by "open" was that anyone with any kind of computer that has a
> reasonably modern browser can access and use a 37signals application. You
> don't need a special proprietary application or framework running on your
> own device to do this.

And I need Windows to run Steam, and I need a Mac to run iPhoto. You're
suggesting an absurd fantasy wherein everything runs on everything. If I want
"open" by your definition of "it's on the Internet" on the iPhone, _I go to
the Internet_.

------
buugs
It is obvious that gruber is an avid mac user from his posts and generally
dislikes windows as many mac users due but this:

        But Windows is proof thatIntroduction
============

Lung cancer is the leading cause of cancer death worldwide.[@b1-ott-11-3111],[@b2-ott-11-3111] There are more than 10 million deaths from lung cancer every year, largely because of the lack of effective early diagnosis and treatment. Despite improvements in the availability and sophistication of lung cancer treatment regimens, such as radiotherapy, chemotherapy, and surgery, the 5-year survival rate remains only 15% and has not increased significantly over the past 20 years.[@b3-ott-11-3111] Studies of the molecular mechanisms of lung cancer have led investigators and clinicians to focus on gene therapy approaches. Unfortunately, most patients with lung cancer have been diagnosed with distant metastasis,[@b4-ott-11-3111],[@b5-ott-11-3111] which requires systemic treatment rather than local treatment. It is still difficult to apply gene therapy to systemic disease.[@b6-ott-11-3111]

Genetic mutations in *MCPH1* result in primary autosomal recessive microcephaly characterized


Pirates who seized a Comoros-flagged oil tanker released the ship Thursday without conditions, according to a Somali official.

Security official Ahmed Mohamed told The Associated Press the pirates have disembarked the ship, which is now heading to Bossaso port, the region's commercial hub.

Mohamed said the release occurred after negotiations by local elders and local officials with the pirates, who seized the tanker on Monday and held eight Sri Lankan crew members hostage.

Earlier Thursday, Naval forces clashed with the pirates after they opened fire.

The hijacking of the Comoros-flagged tanker Aris 13 was the first such seizure of a large commercial vessel off Somalia since 2012.

Abdirizak Mohamed Ahmed, the director of Puntand's anti-piracy agency, confirmed the release of the ship Thursday night to the AP and said naval forces had boardedunforeseen results. This is especially true in the photographic processing industry, where the control of processing chemicals such as developers and fixers must be maintained in order to provide high quality finished photographs or negatives. The same holds true in the X-ray field as well.
Generally, chemicals are shipped from a manufacturer to individual users, and this is most often done in the dry or liquid concentrate chemical form for both safety, economy and convenience. The dry and liquid concentrate chemicals are lighter and thus more economical to ship. Dry chemicals also can be packed in cardboard or like unbreakable containers not as susceptible to spilling and breaking.
This creates a great need for a device and method for preparing the dry or liquid concentrate chemicals properly so that the


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If you are an international customer, outside of the US or Canadadays, Chinese troops encroached over the demarcation line in the Ladakh region, further to the west.

India moved extra troops to positions opposite.

The talks, which took place in the Chushul-Moldo region between the two commanders, is believed to be the highest-level meeting since the Sikkim exchange.

India’s Prime Minister Narendra Modi and his Chinese counterpart Xi Jinping have sought to ease the tensions at summits over the past two years when they agreed to boost border communications between their militaries. — AFP
‘Time for a change’: Anti-racism protesters march across UShttps://www.thesundaily.my/world/time-for-a-change-anti-racism-protesters-march-across-us-CM2538325
86cd240e-c322-463a-bde0-c3641774f0c5Sun, 07 Jun 2020 06:31:00 GMTWorld
WASHINGTON: Tens of thousands of peaceful protesters rallied for racial justice Saturday in cities across the United States following the death of George Floyd, as the movement triggered by his killing at police hands entered


we are all called to the cause.”

A remembrance for Floyd was held Saturday in Raeford, North Carolina, the state where he was born, following a memorial service in Minneapolis on Thursday.

Hundreds waited to view his coffin, some holding umbrellas against the hot sun. Some sobbed and many held cell phones high as a hearse arrived with the casket.

Floyd’s sisters LaTonya and Zsa-Zsa Floyd told reporters they would not go inside.

“I can’t go in, see him laying in a coffin, it would drive me crazy forever,“ said LaTonya through tears.

She expressed her pain at watching the footage of her brother’s agonizing death.

“It’s very hard. Every time I look up I see him on the ground, face up, neck down, hollering please help me,“ she said, adding she wished thesome captured on camera.

In Buffalo, New York, two policemen were charged with felony assault Saturday after they were filmed shoving a 75-year-old protester who fell, hit his head and began bleeding.

In Indianapolis, police launched an investigation after video showed officers hitting a woman with batons and firing pepper balls at her last week.

But there were some changes to policing as well.

In Seattle, authorities announced a temporary ban on tear gas. In Denver, a federal judge forbade the use of chemical agents and projectiles like rubber bullets against peaceful protesters. And in Dallas, police marched in solidarity with protesters.

The unrest has handed US President Donald Trump the target of many a biting protest sign and chant one of the greatest challenges of his tumultuous presidency.

While condemning Floyd’s death, he


very, very bad” -- potentially falling 20 to 30 percent.

“There will be a big decline in economic activity, big increase in unemployment,“ he said in a CBS interview last month.

While economists were expecting the Labor Department’s jobs report for May to show the unemployment rate rising to around 20 percent from its already horrific level of 14.7 percent in April, instead it declined to a still-awful 13.3 percent as the economy added jobs when states began restarting economic activity.

But Kathy Bostjancic of Oxford Economics said the central bank is unlikely to read too deeply into the positive employment data.

“While welcomed by Fed officials, the jobs report won’t change the outcome of the upcoming FOMC meeting,“ Bostjancic said.

“The policy rate will remain pegged near zero until the recovery isfacilities. - Bernama

Sri Lanka to reopen for tourism in August, with multiple coronavirus testshttps://www.thesundaily.my/world/sri-lanka-to-reopen-for-tourism-in-august-with-multiple-coronavirus-tests-CN2528477
915eaae5-8695-475e-bfd5-d2a1d88c59a1Sat, 06 Jun 2020 13:15:50 GMTWorld
COLOMBO: Sri Lanka’s virus-battered tourism industry can reopen for foreign guests from August but under strict guidelines, including multiple coronavirus tests during their stay, officials said Saturday.

Tourism was only just recovering from the effects of last year’s Easter Sunday bombings that killed 279 people, including 45 foreigners, when the virus halted international travel to the island and forced hotels to shut, leaving tens of thousands of people jobless.

Sri Lanka’s tourism ministry said travellers will be able to visit from August 1, but they must carry a Covid-19 free certificate issued not earlier than 72 hours before boarding.

Even with this document, tourists will have to take a virus test


for visitors.

Perdios said several four-star hotels would provide 500 quarantine rooms for close contacts of those who fall ill.

‘Right thing to do’

A raft of other health measures, including disinfection protocols and temperature checks at border controls, aim to protect travellers and locals alike.

“We’ve gone to big lengths to think ahead of things that could go wrong and try to devise plan Bs and Cs”, Perdios said.

The Republic of Cyprus, in the south of the island, has registered 960 novel coronavirus cases and 17 deaths.

Perdios expressed hope that British tourists could be welcomed “sometime after mid-July”, with Russia “slightly later, maybe by a couple of weeks”.

A recently announced deal with Hungarian low-cost carrier Wizz Air to open a base in Cyprus from July was also an important step towardsnot observed, although police appeared not to be enforcing those rules.

The day before the protests Prime Minister Scott Morrison had urged people to stay home.

“Let’s find a better way and another way to express these sentiments rather than putting your own health at risk,“ Morrison said.

He admitted there was more to be done to address indigenous inequality, but rejected parallels with the United States.

“Australia is not other places, so let’s deal with this as Australians and not appropriate what’s happening in other countries to our country at this time.” -AFP
In S.Africa’s virus epicentre, Covid-19 patients get priorityhttps://www.thesundaily.my/world/in-s-africa-s-virus-epicentre-covid-19-patients-get-priority-IN2528390
148879f5-98af-47bd-a62f-68c041e8c458Sat, 06 Jun 2020 10:30:00 GMTWorld
CAPE TOWN: As coronavirus cases spike in South Africa’s Western Cape province, the epicentre of the country’s outbreak, doctors have voiced concern about other diseases being


once the outbreak ended, after having spent months without routine check-ups and treatment.

“We will now have an exhausted healthcare workforce and those patients are still going to be neglected because there is not a recovery plan in place,“ Parkes said.

It is estimated that the virus will create a backlog of about 150,000 procedures in South Africa, according to the Cape Town-based professors Bruce Biccard and Lydia Cairncross in a recent article published in the country’s online Daily Maverickl.

Meanwhile, a growing number of hospital workers are contracting Covid-19 placing additional strain on thinly staffed facilities.

More than 1,700 health workers have been infected since coronavirus hit the Western Cape in March, 17 of whom have died.

The government has strengthened its response by setting up field hospitals and re-deploying military medicaldate, more than 125,000 cases and 4,500 deaths have been confirmed in California. -AFP
Morning sun rise on the Hollywood sign in Los Angeles, California, U.S., February 6, 2020. -ReutersBiden clinches Democratic nomination for 2020 race against Trumphttps://www.thesundaily.my/world/biden-clinches-democratic-nomination-for-2020-race-against-trump-AB2517266
d2b2aaf3-e448-46f2-9f00-e1296cb402aaSat, 06 Jun 2020 06:28:09 GMTWorld
WASHINGTON: Joe Biden said Friday he had secured the delegates needed to clinch the Democratic nomination and face Donald Trump in November’s US presidential election.

“Folks, tonight we secured the 1,991 delegates needed to win the Democratic nomination,“ the former vice president said on Twitter.

“I’m going to spend every day fighting to earn your vote so that, together, we can win the battle for the soul of this nation.”

Biden passed the 1,991 threshold to secure his party’s nomination as counting continued from Tuesday’s round of Democratic primaries.

He


06:04:10 GMTWorld
RECIFE: Hundreds of Brazilians marched Friday over the death of a black boy whose mother, a maid, had entrusted him to her white employer, in an echo of the protests racking the United States.

Five-year-old Miguel da Silva died Tuesday when he fell from the ninth story of the highrise where his mother worked in the city of Recife.

She had left him in the care of the white woman she worked for while she took the family dog for a walk.

Security camera footage played on Brazilian TV shows the white employer interacting with the boy as he stands inside the service elevator, then pushing the button for the top floor and leaving him inside alone.

Media reports said after exiting the elevator the boy climbed through a window,up a balcony railing and fell to his death.

The case triggered a Brazilian take on the protests sweeping the United States over racism and police brutality.

“Vidas negras importam” - “Black lives matter” - said signs carried by protesters in Recife, the capital of the northeastern state of Pernambuco.

“It’s important to be at this protest, because Miguel’s life represents the reality of lots of other black kids, the children of domestic workers. He could have been any one of us,“ said protester Nathalia Ferreira.

Wearing face masks against the coronavirus pandemic and T-shirts with the boy’s picture, the protesters marched from the court of justice to the building where he died.

“We are worried this crime will be taken lightly and left unpunished. It is important that justice be done,“ said


on the ‘+’ button you will also get access to shapes and arrow option. Just tap on the shape you want insert inside the screenshot and it will be added. Then you can choose the color for the shape and choose if you want its border to be thin, thick or even thicker. You also get the ability to fill the shape with the color of your choice.

Instant Share

iOS 11 lets you instantly share the screenshots with friends or colleagues even without saving them. Just tap on the share button from the bottom left side of the screen. You will be presented with a sharesheet that lets you AirDrop the screenshot, share it via your favorite stock or third-party app or perform different actions on it.

Edit multiple screenshotsMackintosh, KC

1946: Ross and Cromarty merged into the new sheriffdom of Inverness, Moray, Nairn & Ross & Cromarty. Sutherland merged into Sheriffdom of Caithness, Sutherland, Orkney & Zetland

See also
 Historical development of Scottish sheriffdoms

References

*
Category:Sutherland
Category:Ross and Cromarty


leachability was obtained in biochar pyrolyzed at 400 °C compared to other biochar products. A higher adsorption removal efficiency of Pb and Cd was obtained by EMI pyrolyzed biochar. Langmuir and pseudo-first-order models were used for description of adsorption isotherm and kinetics.A man who attacked soldiers with machetes at the Louvre museum in Paris was placed under formal investigation on Friday, a judicial source said.

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Egyptian Abdullah Reda al-Hamahmy, 29, was shot and seriously wounded when he launched himself at a group of soldiers on Feb. 3, crying out "Allahu Akbar" (God is greatest) in what French President Francois Hollande described as a terrorist attack.

He has told police that he identified with the beliefs of Islamic State but he had not carried out the attack on orders from the militant group, a judicial source told Reuters earlier on Wednesday.

"The accused was put under formal investigation for alleged attempted murder of public servicemen...in connection with a terrorist venture and criminal terrorist conspiracy...with a view to prepare crime," the judicial source said


having returned from the Beatles' Australian tour. (Photo by Jim Gray/Keystone/Getty Images)

20th May 1965: Beatle John Lennon and his wife Cynthia boarding an aeroplane at London Airport. (Photo by Evening Standard/Getty Images)

SWITZERLAND - JANUARY 31: John Lennon And His Wife Cynthia Skiing At Saint Moritz In Switzerland On January 31St 1965 (Photo by Keystone-France/Gamma-Keystone via Getty Images)

UNITED KINGDOM - FEBRUARY 07: Photo of John LENNON and Cynthia LENNON; while in The Beatles, posed with his wife Cynthia (wearing plastic mac) at Heathrow Airport (Photo by Cummings Archives/Redferns)

7th February 1964: Singer and songwriter John Lennon (1940 - 1980), of British pop group The Beatles, and his wife Cynthia wait for a flight to New York at London Airport. John is wearing the 15 guinea Mary Quant hat that sparkedairport in England on March 13, 1965, prior to flying out with husbands and other members of the Beatle group to Salzburg, Austria, where the group are to continue work on their second film. (AP Photo/Victor Boyton)

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Sad news: Cynthia Lennon, the late John Lennon's wife from 1962-1968, has died at age 75 from cancer. According to a rep, her sole child with the former Beatle -- Julian Lennon -- was with her at the time of her death.

Here's the statement:

"Cynthia Lennon passed away today at her home in Mallorca, Spain following a short but brave battle with cancer. Her son Julian Lennon was at her bedside throughout. The family are thankful for your prayers. Please respect their privacy


Q:

Activating PHP extensions in Bluemix

This is a purely Bluemix question!
I've got code running smoothly on a localhost but when I migrated it to Bluemix my DB connection failed me. Checking the logs I found the issue "Call to undefined function mysqli_init()" HTTP response 500. I have found out that extension have been disabled to make it smaller and have found some details about it: Buildpack options.
Unfortunately I have tried that and failed. Maybe I have misunderstood the solution.

Any Help would be greatly appreciated.
EDIT:
bgconfig --> bp-config solved the "undefined function error"
It seems that some extension have been added but not all. "Fatal error:Class 'PDO' not found in /home/vcap/app/htdocs/db_config.php on line 15"
I have however added the PDO extension in options.json.
I tried adding a php.ini overwrite
But stillOverdorf wrote a piece just last week about a spike in kidnappings and murders in India. His piece delved into the similarities between cases that involved friends kidnapping friends, each seemingly linked to the desire for fast money.

More from GlobalPost: My buddy, the kidnapper

The victims Overdorf described were all from middle- or upper-class families, and the perpetrators appeared motivated to reap the benefits of India's fast-growing economy.

As a result, Overdorf wrote, "a debate has begun over whether these crimes can be seen as an unexpected cost of the country's headlong sprint for prosperity."

Thapar's case supports this theory. What appears to have pushed her killers over the edge wasn't just the desire for money — though they reportedly killed her after she boasted of her family's wealth — but


RETURN OF THE NATIVE, Thomas Hardy, 0-553-21269-9

TESS OF THE D'URBERVILLES, Thomas Hardy, 0-553-21168-4

THE HOUSE OF THE SEVEN GABLES, Nathaniel Hawthorne, 0-553-21270-2

THE SCARLET LETTER, Nathaniel Hawthorne, 0-553-21009-2

THE FAIRY TALES OF HERMANN HESSE, Hermann Hesse, 0-553-37776-0

SIDDHARTHA, Hermann Hesse, 0-553-20884-5

THE ODYSSEY OF HOMER, Homer, 0-553-21399-7

THE HUNCHBACK OF NOTRE DAME, Victor Hugo, 0-553-21370-9

FOUR GREAT PLAYS, Henrik Ibsen, 0-553-21280-X

THE PORTRAIT OF A LADY, Henry James, 0-553-21127-7

THE TURN OF THE SCREW AND OTHER SHORT FICTION, Henry James, 0-553-21059-9

A COUNTRY DOCTOR, Sarah Orne Jewett, 0-553-21498-5

DUBLINERS, James Joyce, 0-553-21380-6

A PORTRAIT OF THE ARTIST AS A YOUNG MAN, James Joyce, 0-553-21404-7

THE METAMORPHOSIS, Franz Kafka, 0-553-21369-5

THE STORY OF MY LIFE, Helen Keller, 0-553-21387-3

CAPTAINS COURAGEOUS, Rudyard Kipling, 0-553-21190-0

THE JUNGLE BOOKS, Rudyard Kipling, 0-553-21199-4

KIM, Rudyard Kipling, 0-553-21332-6

LADY CHATTERLEY'S LOVER, D. H. Lawrence, 0-553-21262-1

SONS AND LOVERS, D. H. Lawrence, 0-553-21192-7

WOMEN INis claimed to be the underlying cause, making it the single most frequent cause of ESRD \[[@pone.0213157.ref003]--[@pone.0213157.ref005]\]. Similarly, DM2 patients have an up to four-fold risk of developing coronary heart disease and a significantly increased risk for cardiovascular mortality \[[@pone.0213157.ref006]\].

Micro- and macrovascular complications in DM2 patients have been linked to cardiovascular risk factors, specifically the degree of hypertension, glucose control, dyslipidemia and tobacco consumption. Pharmaceutical and behavioral management strategies for optimal control of these factors have been developed in interventional studies, leading to a reduction of micro- and macrovascular end points \[[@pone.0213157.ref007]--[@pone.0213157.ref020]\]. However, significant risk for these end points remains, suggesting other components such as limited adherence to therapies and thus risk factor control.

Cohort studies of the general population such as the KORA, Framingham Heart and SHIP studies


is provided in **[Table 1](#pone.0213157.t001){ref-type="table"},** showing comparable data to the full DIACORE study of 3000 patients **([S3 Table](#pone.0213157.s003){ref-type="supplementary-material"}).**

We also observed a substantial degree of micro- and macrovascular comorbidities (**[Table 2](#pone.0213157.t002){ref-type="table"}).** While only 109 (3.8%) patients reported previous laser therapy for diabetic retinopathy, DKD, defined as UACR≥30mg/g, was observed in 743 (25.7%) patients, and 1068 (36.9%) had CKD according to KDIGO 2012 **([Fig 1](#pone.0213157.g001){ref-type="fig"}).** Of the patients with eGFRcrea ≥60 ml/min/1.73m^2^ 1824 (63.1%) did not have elevated UACR and thus did not fulfill the KDIGO definition criteria of CKD. The distribution of patients across the KDIGO 2012 eGFRcrea and UACR categories is shown in **[Fig 1](#pone.0213157.g001){ref-type="fig"}.** The gender-specific distribution of patients across KDIGO 2012 categories is shown in **[S2 Fig](#pone.0213157.s009){ref-type="supplementary-material"}.** Reduced kidney function (eGFRcrea\<60 ml/min/1.73m^2^) was associated with DKDmicro- and macrovascular disease burden in DM2 patients typically seen in an outpatient setting. Since we did not apply a certain level of cardiovascular risk or burden as an inclusion criterion, DIACORE extends information gained from large randomized controlled trials (RCT's) performed in DM2 patients (e.g., ADVANCE, ACCORD, EMPA-REG, ALTITUDE, SUSTAIN-6, VADT), which were ascertained for having a particularly high cardiovascular risk profile \[[@pone.0213157.ref010]--[@pone.0213157.ref012], [@pone.0213157.ref015], [@pone.0213157.ref016], [@pone.0213157.ref021], [@pone.0213157.ref029]--[@pone.0213157.ref031]\]. Consistent with this, we observe that mean HbA1c in DIACORE is lower, macrovascular complications are less frequent and prevalence of DKD is lower than in most of the cited DM2 RCT's. Baseline antihypertensive and glucose lowering therapy in DIACORE and current RCT's is largely comparable, with 79.4%, 84.9--86.0% and 75.1% of patients under antihypertensive therapy and 64.2%, 59.7--60% and 60.2--61%


thank the physicians and health insurance companies supporting the DIACORE study: Axel Andreae, Gerhard Haas, Sabine Haas, Jochen Manz, Johann Nusser, Günther Kreisel, Gerhard Bawidamann, Frederik Mader, Susanne Kißkalt, Johann Hartl, Thomas Segiet, Christiane Gleixner, Christian Scholz, Monika Schober (Chief of Supply Management, Allgemeine Ortskrankenkasse Bayern), Cornelia Heinrich (Communication Manager, Allgemeine Ortskrankenkasse Bayern), Thomas Bohnhoff (Disease Management, Techniker Krankenkasse), Thomas Heilmann (Head of Disease Management, Techniker Krankenkasse), Stefan Stern (Consulting Physician, Allgemeine Ortskrankenkasse Bayern), Andreas Utz (Head of Department, Allgemeine Ortskrankenkasse Bayern), Georg Zellner (Chief of Supply Management, Deutsche Angestellten Krankenkasse), Werner Ettl (Barmer-GEK), Thomas Buck (Barmer-GEK), Rainer Bleek (IKK classic), Ulrich Blaudzun (IKK classic). We further thank the study nurses for their expert work in performing the study visits: Simone Neumeier, Sarah Hufnagel, Petra Jackermeier, Sabrina Obermüller,Mobile device maker BlackBerry is taking a different tack in the encryption debate, saying its smartphones have lawful interception capabilities for government surveillance purposes.

BlackBerry chief operating officer Marty Beard told the FedTalks government information technology summit in the United States that the company takes a balanced approach on interception.

According to Fedscoop, which first reported Beard's remarks, this approach differentiates Blackberry from its competitors, who are "all about encryption all the way."

When asked if Beard's comments meant the company's devices would contain backdoors, a BlackBerry Australia spokesperson said encryption was very important to protect governments, business and individuals from hacking.

"That’s why so many world leaders and CEOs rely on BlackBerry to protect their data," the spokesperson said.

"At the same time, no one wants to see terrorists and criminals taking


Auditory illusions as evidence for a role of the syllable in adult developmental dyslexics.
This study investigated whether adult developmental dyslexics differ from normal controls in early stages of spoken language processing that in turn might be related to specific reading difficulties. Subjects were required to detect prespecified targets under dichotic presentation of auditory nonword pairs. The stimuli were made such that segment migrations were possible. The potential contribution of phonetic features, as well as that of phonemes and syllables, was investigated. The results showed that dyslexics had specifically more syllable-based migrations. This result is discussed in the context of well-documented metaphonological deficits and memory problems of poor readers.However, these
provisions are more in the nature of limitations than specific authorizations.

2
  Parenthetically, I am somewhat uncertain of the materiality of the majority’s analysis
pertaining to the Sentencing Guidelines, since neither Section 9763 nor the County
Intermediate Punishment Act are reposed within those guidelines. To the extent that
the Sentencing Guidelines touch upon county intermediate punishment, see 204 Pa.
Code §303.9(i), I do not read the provision – which requires certain sentencing
recommendations to be considered relative to a short list of enumerated offenses -- as
reflecting any attempt, on the part of the Legislature, to provide for comprehensive
treatment of all offenses which may implicate county intermediate punishment.


Introduction {#s1}
============

The cellular prion protein (PrP^C^) was first described as the substrate for PrP scrapie (PrP^Sc^) (Prusiner, [@B40]; Brandner et al., [@B5],[@B6]), a misfolded and aggregation-prone form of the protein detected in brain tissue of animals diagnosed with transmissible spongiform encephalopathies, now often called prion diseases. These are fatal neurodegenerative diseases occurring naturally in humans and ruminants and include Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, scrapie, and chronic wasting disease. The process of template-directed self-replication of PrP^Sc^ constitutes the core of the "protein only" hypothesis (Prusiner et al., [@B41]), stating that the prion agent consists solely of misfolded PrP^C^ conformers, and in accordance with this, PrP^C^ knock-out (KO) mice do not replicate prions, nor do they develop prion disease (Bueler et al., [@B8]).

PrP^C^ is a highly conserved GPI-anchored proteinstress (Wong et al., [@B50]), and increased excitability of neurons (Khosravani et al., [@B26]).

In bone marrow, PrP^C^ is expressed in long-term hematopoietic stem cells (Dodelet and Cashman, [@B13]; Zhang et al., [@B51]) and may contribute to maintenance of stem cell properties, since bone marrow stem cells derived from PrP^C^ KO mice, contrary to similar cells from wild-type mice, fail to repopulate the bone marrow of irradiated recipient mice, especially after serial transplantations (Zhang et al., [@B51]). Interestingly, the PrP^C^ expression in immune cells is regulated according to their lineage fate. The observation that PrP^C^ expression is maintained at a high level in mononuclear cell precursors and downregulated in granulocytic and erythroid cells during their maturation in the bone marrow suggests that PrP^C^ plays a role in the dynamic


3 months of age. Macroscopic examinations were performed routinely. Fresh bone marrow imprints and smears were made and evaluated after staining with May Grünewald Giemsa. Histological slides were prepared from formalin fixed and paraffin-embedded tissues and stained with hematoxylin and eosin (HE) prior to examination by light microscopy.

Real-time RT-PCR analysis
-------------------------

Total RNA was isolated from PBMCs using the Qiagen RNeasy mini plus kit (Qiagen) following the manufacturer\'s instructions. RNA concentration and purity was analyzed using NanoDrop-1000 Spectrophotometer (Thermo Fisher Scientific), and quality was assessed using RNA Nano Chips on an Agilent 2100 Bioanalyzer (both from Agilent Technologies). RNA was stored at −80°C. cDNA was synthesized using the SuperScript III Reverse Transcriptase, RNase Out, dNTP mix and Random Primers (all from Invitrogen, Life Technologies) at the following conditions: 5 minat 65°C, \>1 min on ice, 5 min at 25°C, 1 h at 50°C, and 15 min at 70°C.

Quantitative-PCR was conducted with LightCycler 480 Sybr Green I Master mix (Roche), with *PRNP* as target gene (F: GTG GCT ACA TGC TGG GAA GT; R: AGC CTG GGA TTC TCT CTG GT) and glyceraldehyde 3-phosphate dehydrogenase (*GAPDH*) as reference gene (F: GGT TGT CTC CTG CGA CTT CA; R: TGG AAA TGT GTG GAG GTC GG). cDNA corresponding to 1 ng RNA was used per reaction. The samples had a total volume of 20 μl, and were run on a LightCycler 480 System (Roche). Conditions: 5 min at 95°C; 40 cycles of 10 s at 95°C, 10 s at 60°C, and 10 s at 72°C; and melting curve with


granulocyte and lymphocyte populations based on FS and SS characteristics. The two rightmost plots show representative PrP^C^ expression on lymphocytes and granulocytes in *PRNP*^+/+^ (*n* = 6) and *PRNP*^Ter/Ter^ (*n* = 2) animals. **(C)** Relative *PRNP* mRNA expression in PBMCs (each genotype *n* = 8). **(D)** Relative *PRNP* mRNA expression in bone marrow (each genotype, *n* = 1).](fcell-03-00044-g0001){#F1}

To investigate whether reduced PrP^C^ levels in *PRNP*^+/Ter^ and *PRNP*^Ter/Ter^ animals would lead to compensatory upregulation of *PRNP* mRNA, relative mRNA expression levels in PBMCs and bone marrow were analyzed. As shown in Figures [1C,D](#F1){ref-type="fig"}, the *PRNP* mRNA expression level in PBMCs from *PRNP*^Ter/Ter^ animals was 16.8% of the expression in *PRNP*^+/+^ animals, whereas the expression level in *PRNP*^+/Ter^ PBMCs was 42.4% of the *PRNP*^+/+^ animals. In the bone marrow, themedian fluorescent intensity of positive cells; or in the case of latex beads, the number of cells that had engulfed 2 beads or more (Figure [4E](#F4){ref-type="fig"} and data not shown).

![**Phagocytosis assays**. Cytospots confirmed the cellular uptake of **(A)** latex beads (green fluorescence), **(B)** *E. coli* (red fluorescence), and **(C)** Zymosan (red fluorescence) in activated monocytes. Additional staining for nuclei (blue) and CD68 (**A** red, **B** and **C** green). **(D)** Gating of live cells based on FS and SS characteristics in flow cytometry. **(E)** Particle uptake in *PRNP*^Ter/Ter^ and *PRNP*^+/+^ cells based on the results from two representative animals. Medium only was used as control. Gates indicate particle-containing cells, and in the case of latex beads, also gates for cells that had engulfed 2 particles or more **(F--H)** Compiled


the genotypes. This correlates with the findings in transgenic cattle (Richt et al., [@B42]). Nevertheless, a slightly higher mean response in the *PRNP*^Ter/Ter^ group consistent through all stimulations could suggest that proliferative differences may be present in more restricted lymphocyte subsets. Furthermore, we quantified the uptake of bacteria, yeast and latex particles by activated blood monocytes in order to approach different activation pathways of phagocytosis (Flannagan et al., [@B16]). We did not find that PrP^C^ deficiency had any influence on the proportion or efficiency of monocytes to phagocytize any of these particle types. Earlier studies on phagocytosis have been performed with cells from PrP^C^ KO mice and have given conflicting results. In an *in vitro* study of phagocytosis of *E. coli* by bone marrow-derived macrophages, the activity wasunder the '006 patent means that this method for preparing functionally graded tungsten carbide materials is inflexible and will likely have few commercial applications.
Likewise, the '460 patent teaches a completely different processing method whereby a graded structure is created through a carburizing treatment—i.e., through a post-sintering heat treatment in a carbon rich atmosphere. However, this extra heat treatment step is expensive and very inefficient. Moreover, this method of production has severe limitations with respect to the depth of the graded zone in a component and the range of graded compositions. In fact, the '460 patent specifies the depth of graded layer to be less than 500 microns, which may not be acceptable for many commercial applications.
Accordingly, while the '006 patent and the '460 patent provide some methods for


PEOPLE

Education

2004-2009 – Master degree studies: Kazimierz Wielki University in Bydgoszcz, Faculty of Natural Sciences, in the field of geography, specialization – physical geography and environment protection (master’s thesis entitled Development of landslides as observed on the left bank of the Lower Vistula valley in the Wiąg region).

Kaszubski M.,
2014,
Spatial and seasonal variability of concentration and composition of suspended load in the Vistula river between Wyszogród and Chełmno (Poland),
[w:] Eds. M. Isabel P. de Lima, Joao L.M.P. de Lima, Advances in Hydrologic Research on Pristine, Rural and Urban Small Basins, Faculdade de Ciencias e Tecnologia da Universidade de Coimbra. Departamento de Engenharia Civil, Coimbra,, s. 60.

Kaszubski M.,
2014,
Conditions of concentration and composition of suspended load in the Vistula River between Wyszogród and Chełmno,
Geophysical Research Abstracts Vol. 16, EGU General Assembly 2014,have more water.”

Ecuador, though small in area, is deemed “mega-diverse” by scientists. Acre for acre it contains a level of species richness unmatched in the rest of the world. With the highest population density in South America, it’s also the third most indigenous, with at least one quarter of the population composed of indigenous peoples. Because protected areas cover almost 19 percent of the nation’s surface area, many indigenous and mestizo communities lie adjacent to or within natural preserves.

Ecuador’s capital city of Quito has witnessed a population explosion—today it is a city of nearly 2 million. As it has grown, so has demand for water. The glacier and páramos of Recay provide life-giving fluid not only for irrigation in Cayambe and other agricultural communities, but also for human


"Later, I heard more stories about ghost marriage. Usually, the dead married the dead (one of my Singaporean friends told me that his uncle had been married to another ghost in a proper ceremony, with all the food, costumes, and trappings), but more rarely, the living married the dead."

"I’d been working on a different novel for eight years prior to writing The Ghost Bride (I’m a very slow writer), and one day, I was reminded of this strange practice of marrying dead people. I sat down and wrote the first chapter of this novel, very much as you see it right now."extension : extensions )
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        return this;
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    public TestDatabaseManagementServiceBuilder addExtension( ExtensionFactory<?> extension )
    {
        return addExtensions( Collections.singletonList( extension ) );
    }

    public TestDatabaseManagementServiceBuilder setExtensions( Iterable<ExtensionFactory<?>> newExtensions )
    {
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        return this;
    }

    public TestDatabaseManagementServiceBuilder removeExtensions( Predicate<ExtensionFactory<?>>


pre-ordered on the PlayStation Store right now, with just the base version coming in at £59.99/$59.99. That's an incredibly steep price for UK residents, but do any of these versions take your fancy? Save up in the comments below.

Yet again another game priced so ridiculously. Do they not understand how exchange rates work? £60 for a game, a GaaS at that, is utterly moronic pricing. There has to be someone in that company who knows how money works, you’d like to think.

Even as a grizzled old, life long fan of Marvel, I'm not willing to be ripped off with this pound for dollar charge which adds an extra ten quid to the price. They can stuff that idea where the sun don't shine and give it a twirl.Thinkstudy is the endotoxemic animal model, which does not completely reflect septic conditions in humans. A variety of experimental animal models have been used to study sepsis pathophysiology and treatment[@B42]. We used an endotoxemia model instead of a polymicrobial sepsis model that may better mimic human sepsis. The reason we chose this model was because the primary experimental question was whether hATSC treatment would modulate inflammation and systemic inflammation abnormalities, especially early in sepsis, can be observed and quantified more quickly and reliably in animal models of endotoxemia[@B43]. Further studies to explore the effects of hATSCs in sepsis should consider polymicrobial models. Also, the timing of exogenous stem cell infusion after injury may be important, but the optimal time point has not yet been established. In this study,


not statistically significant. Pulmonary IL-10 did not differ among the three groups. ^\#^P\<0.017, sham/saline versus LPS/saline group. \*P\<0.017, LPS/saline versus LPS/hATSC group. n= 5 per group. The bar on each graph expresses mean ± standard deviation.](ijmsv10p0008g02){#F2}

![**Effects of hATSC treatments on LPS-induced multi-organ dysfunction.**Biomarkers of organ dysfunction (AST, ALT, BUN, creatinine, and lactate) were measured in serum. LPS increased the levels of each biomarker, demonstrating showed multi-organ injury. Administering hATSCs significantly reduced systemic AST levels (indicator of hepatic dysfunction) in endotoxemic rats (*P* \< 0.017 compared with LPS/saline group). ALT also tended to decrease with hATSC treatment. Kidney function (BUN and creatinine) did not differ between the saline- and hATSC-treated groups. Lactate (an indicator of tissue hypoperfusion) tended to improve in the hATSC treated group. ^\#^P\<0.017, sham/saline vs LPS/salinethe preferential consumption of alcohol in gelatin form on a g/kg body weight basis [@pone.0100697-Nasrallah1].

Aside from changes in drug-seeking, adolescence is also a critical period for brain development, and is accompanied by the maturation of neurocognitive processes that underlie inhibitory control, decision-making, and reward processing [@pone.0100697-Bava1], [@pone.0100697-DoremusFitzwater1]. Tasks of selective attention, working-memory and problem-solving are all correlated with fronto-cortical synaptic pruning and myelination throughout adolescent development [@pone.0100697-Blakemore1]. In general, divergences in the developmental trajectory of adolescent prefrontal cortex and subcortical systems might explain differences in adolescent behavior compared to their older and younger counterparts [@pone.0100697-Casey1], [@pone.0100697-Somerville1]. For example, adolescents demonstrate reduced right anterior cingulate, left orbitofrontal, and left ventrolateral prefrontal cortex activation during a decision-making task involving risky choices [@pone.0100697-Eshel1] and stronger ventral striatum and orbitofrontal cortex activation


the illumination of two spatially distinct ports. During the acquisition phase of this task, a correct nosepoke in the rewarded port resulted in the simultaneous extinction of the port lights and extension of the sipper tube for 10 licks of Ensure. Incorrect nosepokes in the opposing port also caused the extinction of the port lights, but resulted in the omission of the reward (no spout extension). At the end of each trial, the house light was turned off for a varying inter-trial interval of 10 or 15 s. Following this, the house light turned on, cueing the rat to start the next trial with a nosepoke at the center port. The rewarded and omitted sides were counterbalanced across subjects. The session ended after 30 trials or 1 h.

Followingwere measured for all subjects (both EtOH and control groups) on P49 immediately following the last hour-long gelatin access period. Tails were cleaned and sterile single blade razors were used to make a small tail-tip nick for blood collection. Blood samples were stored in heparin at −60°C until measurement. Tail blood (6 µl) and standards (6 µl; 0--200 mg%) were mixed with 375 ml of distilled water and 0.5 g NaCl in 12×75 mm borosilicate glass culture tubes. The tubes were capped and then heated to 55°C for 10-min in a water bath, at which point 1.5 ml of headspace gas was removed with a plastic 3.0 ml syringe and injected directly into an SRI 8610C gas chromatograph (Torrance, CA) equipped with an external syringe adapter and 1.0


ml external loading loop. The oven temperature was isothermal at 140°C and contained a Hayesep D column and a flame ionization detector. Hydrogen gas, carrier gas (also hydrogen), and internal air generator flow rates were 13.3, 25, and 250 ml/min respectively. Peak retention time was 2 min and the areas under the curve were analyzed with SRI PeakSimple software for Windows running on a Dell Inspiron 3500 laptop computer.

Statistical Analysis {#s2g}
--------------------

Body weight and gelatin consumption (g/kg) were analyzed using two way (group × day) repeated measures ANOVAs followed by posthoc tukey tests where appropriate. For consumption analyses, only days with one hour access were included in the statistical model. BELs were compared using a T-test. Risk preference was assessed using a three-way (group × probability × session number)EtOH-High animals did not, differing from control animals on variable risk sessions 3--7 ([Figure 3C](#pone-0100697-g003){ref-type="fig"}; all p≤0.05, all Cohen\'s d≥1.12).

![The effects of adolescent alcohol on adolescent risk preference.\
No difference between groups existed on 100% rewarded trials; however, when the probability became variable, EtOH-High animals chose the risky option more often than control animals (A), and regardless of the probability of success (B). Both Control and EtOH-Low animals showed decreasing risk preference over continued exposure to variable risk, while EtOH-High animals showed no decrease in risk preference over time (C). The order of variable probabilities was randomly selected for each animal, thus "Variable Probability Exposure" refers to the average performance across probabilities (e.g. 1 =  average performance across first exposures to 25%, 50%, and 75% probabilities). Note: \* denotes difference


similar rates. The average number of days to reach criterion for EtOH-High (7.4±1.2), EtOH-Low (7.2±0.4), and Control (7.4±0.9) groups was not significantly different \[F(2,12) = 0.01, p = 0.98\]. Across the days spanning the initial reversal ([Figure 5A](#pone-0100697-g005){ref-type="fig"}), there was an expected main effect of day \[F(11,131) = 26.14, p\<0.001\]. Posthoc analysis showed that on the first reversal day ('Reversal' on P35) there was an expected decline in performance as the contingencies were switched (p\<0.001). From P36--39 (R2--R5), all rats learned the new contingencies, demonstrated by an increase in percent correct choices of the new rewarded port over time. However, there was no significant main effect of group across days \[F(2,131) = 1.9, p = 0.19\], nor were there significant day × group interactions \[F(22,131) = 0.93, p = 0.56\].

![Adolescent acquisition and reversal learning during a spatial discrimination task.\
Average percent correct forto losses in the risk task. There were no reliable differences is preference for the risky over the certain option in the 100% training condition, although behavior for these sessions was more variable than that observed in the reversal learning task. The difference between tasks suggest that reward omission has a strong influence over behavior, but that sensitivity to probabilistic reward omission is modulated by ethanol exposure. While this is consistent with previous findings in adults [@pone.0100697-Clark1], [@pone.0100697-Nasrallah2], here, adolescent rats consuming ethanol did not show any differences in acquisition of our instrumental task during adolescence. The current results cannot clearly rule out differences in incentive salience, as we did not directly measure hedonic responses to delivered rewards to quantify whether they correlate with preference for the risky


factors, you need to make sure that you have an appropriate budget for the kitchen interior design.

]]>http://www.yonohomedesign.com/going-about-with-kitchen-interior-design/feed/0Kitchen wall decor pictures and stickers to accentuate the kitchenhttp://www.yonohomedesign.com/kitchen-wall-decor-pictures-and-stickers-to-accentuate-the-kitchen/
http://www.yonohomedesign.com/kitchen-wall-decor-pictures-and-stickers-to-accentuate-the-kitchen/#respondMon, 12 Jun 2017 04:22:00 +0000http://www.yonohomedesign.com/kitchen-wall-decor-pictures-and-stickers-to-accentuate-the-kitchenYou can enhance the walls of your drab kitchen with kitchen wall décor and make it into a place of decorative interest as you tend to spend much of your time there. Your kitchen and dining room are places where the family and friends usually get together for meals and general laughter. So your kitchen wall décor will make the feel of the kitchen friendly and prosperous.

You can begin beautifying your kitchen by collecting some kitchen wall art pieces. Decorate the walls of the kitchen with sculptures, tapestries and canvasses that include anything like a cluster of grapes DCA is a method for warming the CPU cache before data
	  is used, with the intent of lessening the impact of cache misses.

config IXGBE_DCB
	bool "Data Center Bridging (DCB) Support"
	default n
	depends on IXGBE && DCB
	---help---
	  Say Y here if you want to use Data Center Bridging (DCB) in the
	  driver.

	  If unsure, say N.

config IXGBE_IPSEC
	bool "IPSec XFRM cryptography-offload acceleration"
	depends on IXGBE
	depends on XFRM_OFFLOAD
	default y
	select XFRM_ALGO
	---help---
	  Enable support for IPSec offload in ixgbe.ko

config IXGBEVF
	tristate "Intel(R) 10GbE PCI Express Virtual Function Ethernet support"
	depends on PCI_MSI
	---help---
	  This driver supports Intel(R) PCI Express virtual functions for the
	  Intel(R) ixgbe driver.  For more information on how to identify your
	  adapter, go to the Adapter & Driver ID Guide that can be located at:


<http://support.intel.com>

	  More specific information on configuring the driver is in
	  <file:Documentation/networking/device_drivers/intel/ixgbevf.rst>.

	  To compile this driver as a module, choose M here. The module
	  will be called ixgbevf.  MSI-X interrupt support is required
	  for this driver to work correctly.

config IXGBEVF_IPSEC
	bool "IPSec XFRM cryptography-offload acceleration"
	depends on IXGBEVF
	depends on XFRM_OFFLOAD
	default y
	select XFRM_ALGO
	---help---
	  Enable support for IPSec offload in ixgbevf.ko

config I40E
	tristate "Intel(R) Ethernet Controller XL710 Family support"
	imply PTP_1588_CLOCK
	depends on PCI
	---help---
	  This driver supports Intel(R) Ethernet Controller XL710 Family of
	  devices.  For more information on how to identify your adapter, go
	  to the Adapter & Driver ID Guide that can be located at:

	  <http://support.intel.com>

	  More specific information on configuring the driver is in
	  <file:Documentation/networking/device_drivers/intel/i40e.rst>.

	  To compile this drivera way to see that there is no closed-form.
Note that if all $a_n>1$, the derivative says
$$f'(x)=\sum_n\log a_n{a_n^x},$$ which is a positive expression. Then for $b>0$ there is a single solution. If $b\gg1$, a good approximation is given by the leading term,
$$x\approx\log_{a_{max}}b$$ where $a_{max}$ is the largest constant.

It is also interesting to look at the function
$$\log\left(\sum_n{a_n^x}\right),$$ which is asymptotic to $x\log a_{min}$ in the negatives and $x\log a_{max}$ in the positives, hence the graph is made of two smoothly connected half-lines.
For the given example:


Find cheap airfares for flights from Vienna to Abidjan. Use Wego.com.sg to search and compare low airfare airline tickets for Vienna to Abidjan flights on various international airlines. FInd last minute flights and the latest low airfares for this route. Compare cheap Vienna to Abidjan flights at a glance and get the best deal for your trip.1. Field of the Invention
This invention relates to electric heaters, and more particularly to such heaters utilizing support insulators for retaining and securing electric heater coils therein.
2. Description of the Prior Art
Electric heaters utilizing resistance wire supported in a frame are known in the art. Such heaters, typically called open-coil heaters, require the use of insulators to separate the resistance wire from the frame structure and to avoid the possibility of a short circuit between the resistance wire and the frame. Heaters of this type similarly require the use of means for retaining the resistance wire in a predetermined, desired configuration with respect to the frame.
Prior art devices are known which attempt to provide insulators including coil holders for retaining a heater coil and insulating the same from


on the clip means to secure the same on the insulators. In summary, a structure is disclosed in the reference, requiring a number of complicated steps eliminated by the present invention. Specifically, the presently disclosed structure embodies a unified insulator support which may be easily mounted in the cross beams of a frame. The mounting process utilizes a first set of notches in the insulator structure, while the coil is secured by a second set of notches. Tabs are not required, and assembly of the device is simplified.
Simmons, U.S. Pat. No. 1,698,282, similarly discloses an electric heater incorporating insulators, or supports, which require special manipulation for mounting on the cross beams. Additionally, each support structure requires the use of two insulator elements. Simultaneous manipulation of the two elementsthe body with respect to the heater coil support means. Accordingly, the possibility of providing a single support structure capable of supporting electric wire on both sides of a support beam is precluded by the disclosed structure. As in Wightman et al., tabs are required to be manufactured in the support beams for the insulators, and as in Simmons, special rotational steps are needed for mounting the insulators on the heater reflector.
Other teachings of insulators and spacers used in conjunction with electric heaters include McKeown U.S. Pat. No. 2,177,930; Gasparaitis, U.S. Pat. No. 3,632,981 and Laing, U.S. Pat. No. 3,218,437. Weimar, U.S. Pat. No. 1,712,860 discloses the use of two insulators above and below a cross arm of a telephone, electric or telegraph pole, the insulators having an


annular groove for the wire.
It is accordingly seen that none of the prior art references discloses, either singly or in combination, an insulating support which provides an easily fabricated, easily assembled and simplified structure for supporting resistance wire in electric heaters. The present invention provides an insulator supporter, for an electric heater, which is integrally formed and is substantially symmetric. These features permit insertion of the insulator within the support beam structure of an electric heater with a minimal orienting and aligning effort, and further permit straightforward assembly of the heater wire to the frame by simplified attachment to the insulator.
Mounting of the insulators to the support beams is accomplished by insertion into a cavity, a snapping or clipping action taking place between the beam structure and notchesFor the first time in human history, global farmed fish production exceeds beef production. This from a civilization that has propagated cattle to nearly twice its own biomass and which utilizes over a third of the planet's ice-free land surface for agriculture.^[@CR1],[@CR2]^ In 2016, salmon surpassed tuna to become the second most-consumed seafood in the United States, second only to shrimp.^[@CR3]^

It is estimated that 91% of the seafood consumed in the United States is imported, of which nearly half is produced through aquaculture.^[@CR4]^ The United States Food and Drug Administration (FDA) inspects only approximately 2% of imported seafood, of which less than 0.1% is tested for banned chemical residues.^[@CR5]^ In 2017, the FDA inspected 86 samples from 379,000 tons of imported salmon.^[@CR6]^

Norway is the global leader in salmon


were sampled from Colorado and North Carolina supermarkets contained significantly higher levels of formaldehyde than fish from domestic sources.^[@CR14],[@CR15]^ While formaldehyde naturally occurs in trace amounts in most living tissues, its formation is accelerated in decomposing fish tissues by the reduction of trimethylamine oxide.^[@CR16]^ In 2015, Alaskan fisheries reported record catches of wild salmon,^[@CR17]^ of which an estimated 70% was exported.^[@CR18]^ Some of this fish is processed in China, then imported back to the United States where it can be labeled "wild caught Alaskan salmon".^[@CR19]^ The FDA does not routinely inspect seafood imports for formaldehyde.

In aquaculture, open net cage systems concentrate large populations of fish in confined areas making them particularly susceptible to parasites and the rapid spread of disease. Sea lice infestations (*Lepeophtheirus salmonis* and *Caligus elongates*)for a minimum of 30 minutes a day. It is especially helpful when I do not go out of the house and this is the only exercise that i get. I like that it is compact and does not take up a lot of room.
My light workout, anti-couch solution!
For the occasional times that I regrettably veg-out on the couch for a few hours in front of the tv , this is a nice solution! This lightweight, QUIET, small, folding, easily stowed treadmill is perfect for light exercise while catching up on a few shows. And the price was perfect for someone hesitant to buy yet another piece of exercise equipment that eventually just gathered dust before being sold or donated. This one I think will get regular use


U.S. influence in the Middle East.

United Nations Syria mediator Staffan de Mistura has said he intends to convene separate peace talks in Geneva on Feb. 8. The U.N.-backed talks have been held intermittently. Russia says the Kazakh talks would complement rather than compete with the U.N. talks.Budget should revive Infrastructure investments : CII

Date

25-Feb-2016

Subject

Budget should revive Infrastructure investments : CII

NEW DELHI : The Union Budget for 2016-17 will be announced at a time when the macro-economic milieu continues to be domestically and globally challenging and the focus should be on stepping up the pace of investment expansion for achieving higher growth and job creation.

The Confederation of Indian Industry (CII) looks forward to suitable policy interventions which would rekindle business sentiment and thereby help to debottleneck the economy.

“Considering that broad based revival of private investment is being constrained on account of weak order book situation resulting in capacity overhang, there are hopes and expectations that the forthcoming Budget would increase spending by the Government, the public sector and by quasi-Government bodies” according to Mr Chandrajit Banerjee,


When it comes to your business, there is no more critical aspect of your brand identity that your logo. Logos provide consumers with a visual representation of your company and provides an anchor for your brand. For this reason, a well-designed logo is an essential part of any company’s overall marketing strategy.

Purpose

Logos provide a face for your company. They provide a visual display of who you are as a company and communicate a strong message through the use of specific colors, images and words. Each of these elements will influence how a customer feels about a particular company and what they are offering. Logos, in short, are the very foundation of a company’s identity and marketing efforts.

Design Principles

A good logo has to be unique as well as provideQ:

How to ensure data sent via JSONP is secure?

I need to ensure that data sent out from a script is as secure as possible. The server-side language is PHP.
Any tips would be greatly appreciated.
UPDATE: What I mean is. I need to ensure the data sent from my server cannot do damage to the other server that is retrieving it. I'm not worried about the security or people seeing the data that's being sent, just need to make sure it can't harm the other site.

A:

It is totally safe if everything is properly escaped. If your delivered JSON is valid, there is no security risk (assuming that the other side does not use evil eval on some of the values).


 using (SqlCommand _commandSqlCe = new SqlCommand(CommandSQL, _connSql))
            {
                _commandSql.CommandType = CommandType.Text;
                _commandSql.ExecuteNonQuery();
            }
        }
    }
    catch { throw; }
}

The general format of SQL INSERT query string is shown below:
INSERT INTO YourTable (column1,column2,column3,...)
VALUES (value1,value2,value3,...);

You can further extend this solution by adding parameters to the SQL String/Command in order to protect against possibility of SQL injection (see the following example):
INSERT INTO YourTable (column1,column2,column3,...)
VALUES (@param1,@param2,@param3,...);

_commandSql.Parameters.Add("@param1","abc");
_commandSql.Parameters.Add("@param2","def");
_commandSql.Parameters.Add("@param3","ghijklm");

YouTerms and Conditions

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Euler's and Carmichael's can be used interchangeably to generate the public key in RSA?

Yes.  The requirement is that the public exponent $e$ have an inverse modulo $\phi(n)$ or $\lambda(n)$, whichever you use—and the two numbers share prime factorization, differing only in multiplicity, so $e$ is coprime with $\phi(n)$ iff $e$ is coprime with $\lambda(n)$.

To compare their 'effectiveness' I will first compare the amount of time it takes to generate a public key using each function based on time complexity. Secondly, I want to compare the security of the public key (meaning 'how difficult it is to guess the private key given the public key'). But how? Is there an algorithm to use to test the security of an encryption key?

There is no algorithm to test the securityWhile Facebook certainly wants to collect all of your personal data, it also has become quite sophisticated in its efforts to allow you to control how your data is shared. This wasn’t something that came naturally to them, but was forced upon them by years of crazy indiscretions which forced their hand.

HIPAA has come from the other end. While HIPAA is the portability act and not the privacy act (common mistake), that’s not how it was viewed when it was implemented. Everyone in healthcare saw HIPAA as a way to inhibit data sharing as opposed to a way to provide a framework for secure data sharing. In many cases, that’s still how people use HIPAA today. However, we’re starting to see that change as healthcare organizations have realized


that their organizations need to share data. While not as progressive as Facebook in their data sharing controls, healthcare has become much more specific about how, when, what, and where they share patient data.

While we can find plenty of privacy and security issues with Facebook and HIPAA, I’d argue that both of them have become much more sophisticated in their approach to privacy and security. I believe this trend will only continue to get better.

What does all of this mean for healthcare?

Healthcare can learn a lot from Facebook when it comes to creating sophisticated privacy options that put the patient in control of their health data and allow the patient to control if and when that data is shared. However, we shouldn’t be surprised when we implement theseDespite significant progress in the identification of mechanisms involved in motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS) and other motor system diseases, the actual pathogenesis and cause of these diseases remains unknown. Effective treatment of these diseases are dependent on the elucidation of their causes. The availability of diseased and control human tissues will be a critical resource for this research progress. . Samples of serum, spinal fluid, and urine from patients with motor system diseases can be used to study biochemical and genetic differences compared to tissues of neurologic disease controls and normal controls. Furthermore, the availability of autopsied CNS, PNS, as well as other tissues from patients with ALS or suspected ALS are useful for current and future research studies into the disease. Therefore, we


delays in collecting specimens prospectively. These specimens will be used for research in the ALS Center of Hope at Drexel University College of Medicine and shared with any outside investigator with a valid IRB approved protocol.

In the case of spinal fluid collection, the patient will be undergoing a diagnostic lumbar puncture as part of the work-up

Exclusion Criteria:

Any person with a non-neurologic chronic and poorly controlled systemic illness

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.govBlood pressure, fatness, and fat patterning among USA adolescents from two ethnic groups.
Many studies have explored the relationship between blood pressure and body size and composition in adults and preadults, but none has inquired into the relationship of blood pressure and the anatomical distribution of subcutaneous fat (fat patterning). Fat patterning has an association with chronic diseases (diabetes and cardiovascular disease) in adults. We sought the relationship between fatness, fat patterning, weight, and height among adolescents (12 to 17 years of age) of two ethnic groups (black and white) from the Health Examination Survey. Systolic blood pressure adjusted for age was related to body build variables in all sex/ethnic groups in decreasing order of importance as follows: body weight (independent of height), fatness (as assessed by a two


After Sunday's announcement from ESPN that the network remains unsure who modified Chad Ford's NBA pre-draft rankings years after the fact, we immediately asked, "How is that possible?" Nearly every known content management system tracks changes, and we're told ESPN's usual process is especially well-monitored, with editors maintaining full oversight over what information appears on every page of ESPN.com.

But we've been told by multiple current and former ESPN employees, none of whom wanted their names used, that the specific system used for the ESPN Insider NBA draft rankings pages runs under an entirely different, dynamic process—one they suggest is outdated and a remnant of the old Go.com era—and that the data administration tool used to construct the draft page has "far less oversight and audit records" than ESPN's res = mat.template selfadjointView<Upper>().twistedBy(p_null);
  res_d = up_sym_d;
  VERIFY(res.isApprox(res_d) && "full selfadjoint upper to full");

  res = mat.template selfadjointView<Lower>().twistedBy(p_null);
  res_d = lo_sym_d;
  VERIFY(res.isApprox(res_d) && "full selfadjoint lower to full");

  res = up.template selfadjointView<Upper>().twistedBy(p_null);
  res_d = up_sym_d;
  VERIFY(res.isApprox(res_d) && "upper selfadjoint to full");

  res = lo.template selfadjointView<Lower>().twistedBy(p_null);
  res_d = lo_sym_d;
  VERIFY(res.isApprox(res_d) && "lower selfadjoint full");

  res = mat.template selfadjointView<Upper>();
  res_d = up_sym_d;
  VERIFY(res.isApprox(res_d) && "full selfadjoint upper to full");

  res = mat.template selfadjointView<Lower>();
  res_d = lo_sym_d;
  VERIFY(res.isApprox(res_d) && "full selfadjoint lower to full");

  res = up.template selfadjointView<Upper>();
  res_d = up_sym_d;
  VERIFY(res.isApprox(res_d) && "upper selfadjoint to full");

  res = lo.template selfadjointView<Lower>();


not put you a lot of troubles. A simple one-hand expression is easy to adjust to your comfort and preference by means of the 8-level suction control button. And the LED lights indicate the current operation level. A soft Flexi-fit™ breast shield ensures proper adherence for your ultimate comfort and efficient pumping. This notable electric breast pump features extremely easy hassle-free operation to help you breastfeed longer and maintain stable milk supply.

Usability

Owing to its sleek design and noiseless operation this electric breast pump is incredibly easy to assemble and operate. A nice-looking tote bag makes the unit highly portable for discreet travel use. A stand-like pump cradle contains 4 AA batteries allowing you to use this electric breast pump without connection to the mains and making it anseparating the tubing from the collection bottle and the breast cup. This system is considered more hygienic and significantly facilitates cleanup. While in the open system the milk flows to the tubes and they require regular deep cleaning. Basic breast pump set consists of a pump, connection kit, milk bottle and a breast shield as well as some other extra accessories. A handle on a pump body contributes to its portability and the breast shield prevents leakage during pumping. For your ultimate convenience, some models feature a pump embedded in a tote bag or the tote bag is included in the set as a separate item. The majority of breast pumps come with a milk bottle. You can attach the nipple to the bottle and feed the baby