of unique terminal chromosomal DNA sequences at the time of assay development, it is unlikely that certain telomere ends are more likely to form fusions in the current 14% coverage range. Therefore, in light of the apparently stochastic nature of fusions indicated by our previous work, it is improbable that fusions in ovarian cancer would occur at significantly different frequencies. This data provides striking evidence for the pervasive and potentially ubiquitous nature of telomere dysfunction in ovarian cancer, a unifying characteristic of a profoundly heterogeneous disease that may act as a driving force in tumorigenesis.

Previously published data on ovarian cancer has shown that ovarian tumors exhibit significantly shorter telomeres than normal tissues \[[@B28-cells-08-00414],[@B29-cells-08-00414],[@B30-cells-08-00414]\]. Other research, however, has indicated that changes in telomere length can include both shortening andelongation and that telomere length has no significant relationship to the stage of disease. \[[@B31-cells-08-00414],[@B32-cells-08-00414]\]. One difficulty in assessing the importance of telomere length is the fact that assays performed on frozen tissue samples only provide a snapshot of telomere dynamics at one specific moment in time. Investigators are left to discern whether or not the conditions observed in telomere maintenance have reached a stable, static state or if they are moving toward one extreme or the other. Captured in a brief moment in time, it is difficult to know if the telomere lengths measured in an assay represent a constant, stable length that has remained at that level for an indefinite period of time, if they are in the process of shortening with successive cell divisions, or


if telomere-elongation pathways such as activated telomerase or alternative lengthening of telomeres (ALT) \[[@B33-cells-08-00414]\] may be lengthening them and rescuing them from genomic crisis. Each individual tumor may differ from others in this regard, and intra-tumoral heterogeneity may even cause differences in telomere dynamics within the same tumor. Malignant cells in a tumor tissue may feature critically short telomeres, while non-malignant neighboring cells may have telomeres of a more normal length. This potentially broad variety of telomere length in the cells of a single tumor may skew the mean telomere length measurements for these tissues and prevent an accurate comparison of tissue types. Given these potential complications with determining telomere length in tumor tissue samples, here we found significant shorting of telomere lengths in ovarian tumor tissue cellsQ:

Running Android Emulator together with a VirtualBox machine

I'm on Windows 10 1903 and need to run a Linux VM while working with the Android Emulator. I'm on an AMD Ryzen 5 3600x CPU.
If I disable Windows Hypervisor Platform, the VM works, but the emulator doesn't (other than arm images, I believe, but I haven't tested those, as their performance isn't ideal).
VirtualBox seems to have some recent support for this, but the latest Windows update broke it as per this thread.
Apparently, using the Genymotion emulator is an option, but not a free one, unfortunately.
Switching to Linux is also not an option.
Is there a way to do this without relying on arm images? Any ideas would be appreciated, as I've already sunk way too much time on this.
For some


Infant colic is a pediatric disorder of unknown etiology. Colic is characterized by excessive crying and it affects 20% of U.S. infants, whether breast-fed or formula-fed. Colic is important because of infant pain, parental frustration with inconsolable crying, some infant abuse mortality, pediatrician effort, expense, and lack of effective treatment. Since levels of bovine IgG (BGG) in infant formulas and human milk are comparable, and breast milk BGG levels seems to correlated with colic, an investigation of whether dietary BGG might be a major cause of colic is proposed. BGG is the major foreign immunoglobulin in the human diet (often 500 mg/day) and has unique properties of intentional transport, stability, binding to Fc receptors, and immunomodulation. In vitro studies suggest that BGG may profoundly influence the developing mucosalof this house. The driveway. And you had the real life Taqwacore punks and the film Taqwacore punks. The fiction and the reality, all the borders are gone.

Correspondent: But drawing from events so explicitly, what do you do to invent? To draw the distinction between something that is personally experienced versus what you concoct? Such as the idea of a Muslim punk scene.

Knight: I don’t know, man. Because in Osama Van Halen, I have a fictional character. So sometimes I’m writing from the omniscient narrator. Sometimes I’m writing myself. Like the real-life author. First person narrative. Sometimes I’m talking about this fictional Mike Knight. And it’s almost like there’s no distinctions anymore. I mean, I just wrote myself getting my head chopped off. And now I’m afraid that’s


application whose utility and value to end users is closely aligned to the speed the end user can achieve.

Even at 15 Mbps - and assuming that speeds were symmetric, which they won't be - cloud backup of a 500 GB MacBook Air is a nine-hour process that would exclude any other application; at 2.5 Mbps it's simply not feasible (more than 55 hours).

The report assumes that the kind of burst capacity that the NBN would provide over fibre has no utility to end users – and that assumes the one thing that Turnbull denied in 2013: that the future can be predicted with sufficient certainty to define a fine-grained bandwidth requirement nine years hence.

Usage != Demand

In gauging demand as a proportion of a contrived “access network capacity” number,the report assumes that user behaviour is solely a reflection of the services they want to buy.

This isn't true: Australian fixed-line broadband user behaviour is constrained by the cost structure of the industry, leading to the imposition of download caps. As a network engineer said to The Register: “With the cap, virtually all of the actual utilisation numbers you can dream up are artificially constrained.”

And why the caps? Because ISPs have to buy transit to the Internet from a relatively small pool of providers, and they want to minimise their costs. “In the absence of those charges, the pressure on ISPs to constrain utilisation would largely evaporate, and usage would consequently increase far in excess of Vertigan’s estimates,” the engineer said. ®

Bootnote: The original version of this article,


into submission.” She was harangued to renounce her admiration of Rushdie’s works. She says: “I could just as easily burn my Oscar Wilde collection because some homophobes came calling.”

Many of us have compared Islam or Islamic totalitarianism with its Soviet and Chinese counterparts. What the Muslim community of Durban and the doctors at St Joseph’s Mental Hospital in Durban are doing is incarcerating a healthy person– even if, as The Guardian notes, she was admitted “voluntarily” after being pressured by family. They may not represent state power—but for a Muslim dissident, they do. This mistreatment is precisely what Soviet Russia and China have done to many of their dissidents.

According to Richard J. Bonnie, LLB, in The Journal of the American Academy of Psychiatry and the Law, this isfamily, laughing kids and overgrown garden.

Please note: Dala does not venture her opinion on any literary matter.

In my expert opinion, with all due respect to PEN’s efforts, Dala might still have not been released unless she was able to demonstrate some genuine remorse and a willingness to either publicly recant her views about Salman Rushdie’s “literary style” or to keep quiet about the matter. A tweet she sent from the mental facility in which she claims her comments on Rushdie were misquoted seem to indicate that may be precisely the direction she will take in publicly addressing the matter.

Now, she knows what her family and her community will do to her if she steps out of line.


The present invention relates to an electric tool, operated independently from the mains, which comprises an electric motor for operating the electric tool as well as a battery. In addition, the electric tool comprises a monitoring device for monitoring a monitoring operation-value limit, wherein the monitoring operation-value limit lies above an operation-value limit of the battery. Furthermore, the electric tool comprises an adjustable resistor component for varying the power output of the electric motor as well as an operation-value controller for setting at least one of the operation-values present at the electrical motor by means of pulse width modulation (PWM).
Furthermore, the present invention relates to a method for controlling an electric motor in an electric tool, operated independently from the mains, by means of a time-controlled monitoring ofthe control electronics of the electric tool, from malfunctioning, damage, or destruction. The undervoltage lockout prevents the continued use of the electric tool until the battery again puts out a voltage lying at least above the supply voltage limit. Such an interruption in using an electric tool caused by the undervoltage lockout represents a substantial impairment for the user, since a shutoff due to an undervoltage is associated with a relatively long waiting period until one can continue using the electric tool.
Extreme environmental influences, particularly low temperatures, i.e., temperatures that lie well below a conventional room temperature of approx. 18° C., cause in some cases drastic output reductions in storage batteries. The reason is that in the cold, chemical processes proceed more slowly and the viscosity of the


a voltage regulator, and the at least one operation-value by the operating voltage. One can hereby prevent the voltage of a battery from dropping again below the operation-value limit of the battery, whereby a shutting-off of the electric motor to protect the battery or other systems can be prevented and simultaneously one can continue using the electric tool.
Additional advantages are revealed in the following drawing description. The drawing depicts an embodiment of the present invention. The drawing, the description, and the claims comprise numerous features in combination. A person skilled in the art will appropriately consider the features also on an individual basis and bring them together in other reasonable combinations.be checked. The strategy of calculations below will be the same. At first we consider coefficient before positive degree of $D$. In nonlocal sums we find terms of the same structure in both sides. All non locality cancels. And summation it is possible perform in explicit form. In some cases under consideration below one of the factors in the expression under summation fixed uniquely value $\nu_P$ and thus it is possible to take this factor out of the sign of the sum with further summation in explicit form.

Checking of the elements of $(1+N^1+N^0\times 1+N^1+N^0)$ quadratical matrix of right upper corner of (\[JHF\])
---------------------------------------------------------------------------------------------------------------

For these elements $\Gamma_i=\tilde \Gamma_j=0$ and the main equation (\[JHF\]) looks as (we introduce additional notation $J^p_1\equiv J^0_1+J^1_1$) $$\phi'(f)J^p_1={\stackrel{T_M\rightarrow}{J^p_1}}((\phi'(f)^{-1})^T$$ 0r in more detail form $$[\sum_{P}{\phi'_{R,P}X_{-P}\over c_P},X_{-R'}]{1\over c_{R'}}={1\over


by Data.
  optional int64 revision = 3;
}

// ControllerRevisionList is a resource containing a list of ControllerRevision objects.
message ControllerRevisionList {
  // More info: https://git.k8s.io/community/contributors/devel/sig-architecture/api-conventions.md#metadata
  // +optional
  optional k8s.io.apimachinery.pkg.apis.meta.v1.ListMeta metadata = 1;

  // Items is the list of ControllerRevisions
  repeated ControllerRevision items = 2;
}

// DaemonSet represents the configuration of a daemon set.
message DaemonSet {
  // Standard object's metadata.
  // More info: https://git.k8s.io/community/contributors/devel/sig-architecture/api-conventions.md#metadata
  // +optional
  optional k8s.io.apimachinery.pkg.apis.meta.v1.ObjectMeta metadata = 1;

  // The desired behavior of this daemon set.
  // More info: https://git.k8s.io/community/contributors/devel/sig-architecture/api-conventions.md#spec-and-status
  // +optional
  optional DaemonSetSpec spec = 2;

  // The current status of this daemon set. This data may be
  // out of date by some window of time.
  // Populated by theinfo: https://kubernetes.io/docs/concepts/workloads/controllers/replicationcontroller/#what-is-a-replicationcontroller
  optional int32 replicas = 1;

  // The number of pods that have labels matching the labels of the pod template of the replicaset.
  // +optional
  optional int32 fullyLabeledReplicas = 2;

  // The number of ready replicas for this replica set.
  // +optional
  optional int32 readyReplicas = 4;

  // The number of available replicas (ready for at least minReadySeconds) for this replica set.
  // +optional
  optional int32 availableReplicas = 5;

  // ObservedGeneration reflects the generation of the most recently observed ReplicaSet.
  // +optional
  optional int64 observedGeneration = 3;

  // Represents the latest available observations of a replica set's current state.
  // +optional
  // +patchMergeKey=type
  // +patchStrategy=merge
  repeated ReplicaSetCondition conditions


percentage of desired pods (ex: 10%).
  // This can not be 0 if MaxUnavailable is 0.
  // Absolute number is calculated from percentage by rounding up.
  // Defaults to 25%.
  // Example: when this is set to 30%, the new ReplicaSet can be scaled up immediately when
  // the rolling update starts, such that the total number of old and new pods do not exceed
  // 130% of desired pods. Once old pods have been killed,
  // new ReplicaSet can be scaled up further, ensuring that total number of pods running
  // at any time during the update is at most 130% of desired pods.
  // +optional
  optional k8s.io.apimachinery.pkg.util.intstr.IntOrString maxSurge = 2;
}

// RollingUpdateStatefulSetStrategy is used to communicate parameterand sew it to the back of his Batman shirt to really complete the picture of the vigilante superhero whose cape seems pretty useless actually since he doesn’t even fly but somehow he’d be super lame without, I say “sure, son, I’ll get right on that.” Because consider the alternative: he could be asking me to make a human skin suit.

And when the bat apparel has finally vanished into the night and it’s time for a little colour in my super son’s super life, I have to let him wear his red pants and red shirt – and neon orange socks because he doesn’t have any red socks and these are the closest thing. Because in this get-up, he is THE FLASH. The scarlet speedster he’s been drawing


   browser.
    web            port=Port [dir]       launch the web ui
    help                                 Show the program options
    version                              Show version information

And more general options

    $ erica -h
    Usage: erica [-h] [-c] [-v] [-f] [-V] [--is-ddoc <is_ddoc>]ethers or divinyl glycol. CARBOPOL® has been used in a number of vaccines, but its use as an adjuvant has not been proven.
Some adjuvants have been shown to stimulate a Th2 response, with examples including N-(2-Deoxy-2-L-leucylamino-b-D-glucopyranosyl)-N-octadecyldodecanoylamide hydroacetate, also known by the trade name Bay R1005® when in its acetate form, and aluminum. Bay R1005® in combination with purified virus vaccines or subunit vaccines led to increased production of antibody in virus-challenged mice. Preclinical trials in other animal species (pig, sheep, horse) gave comparable results with respect to antibody production. The increase in antibody synthesis induced by Bay R1005® is specifically dependent on the antigen and is not the result of polyclonal stimulation.
Prior to this invention, no adjuvant formulation possessed the broad range of desirable characteristics an ideal adjuvant


   var result = GUI.Toggle(toggleRect, selected, GUIContent.none, style);
            if (Event.current.type == EventType.Repaint)
                styles.leftButtonLabel.Draw(toggleRect, selectedContent, false, selected, false, false);
            toggleRect.x += toggleRect.width;

            return EditorGUI.EndChangeCheck() && result;
        }

        public static void ChooseGeneratorOperation(ref CSGOperationType? operation)
        {
            if (styles == null)
         and troop support functions around a campus green.

HIGH-PERFORMANCE DESIGN

The entire Fort Bliss Expansion Program made an immediate positive impact on the community and the environment through high-performance planning and design. TeamBliss consulted with the Green Building Certification Institute (GBCI) to use a “campus” approach for documenting Fort Bliss LEED achievements. Credits were documented pertaining to site/base related components, such as the overall Stormwater Pollution Prevention Plan, site selection, open space maximization, stormwater quality, heat island impacts, exterior light pollution reduction and water-efficient landscaping.

Subsequent building projects referred back to the original “campus” submission to claim all of the documented credits that applied within the building’s LEED boundary. This approach was developed in conjunction with GBCI specifically for use at Fort Bliss, one which had never previously been applied to


above politics and produce a government of laws, and not of men--should find this book invaluable.”

See key exchange around 15-minute mark below.

Get real-time updates as this story unfolds. To start, just "star" this story in ABC News' phone app. Download ABC News for iPhone here or ABC News for Android here.Today's Best Clubs Top Current Soccer Players Greatest Soccer Players Ever South American Footballers History's Greatest Goalies The Very Best Soccer Brands Top Current Female Soccer Players History's Top Defenders Coolest Footballers '90s Soccer Hall of Famers Best Players in the Premier League Vietnamese Footballers Brazilian Footballers The Best Soccer Countries Ever Current Coaches & Managers Top European Soccer Leagues German Footballers Egypt Footballers Top Women Soccer Players French Footballers
To be honest, this ball’s a bit like a classic car, in that it’s awesome – when it works. The Jabulani is prone to valve issues, although they can be fixed. If you need something durable, we wouldn’t recommend this ball. However, if you’re looking to add an awesome ball to your collection – and you’ve got the cash


<?php

/**
 *  2Moons
 *   by Jan-Otto Kröpke 2009-2016
 *
 * For the full copyright and license information, please view the LICENSE
 *
 * @package 2Moons
 * @author Jan-Otto Kröpke <slaver7@gmail.com>
 * @copyright 2009 Lucky
 * @copyright 2016 Jan-Otto Kröpke <slaver7@gmail.com>
 * @licence MIT
 * @version 1.8.0
 * @link https://github.com/jkroepke/2Moons
 */

// Translation into Russian - Copyright © 2010-2013 InquisitorEA <support@moon-hunt.ru>

$LNG['back']                  = 'Назад';
$LNG['continue']              = 'Дальше';
$LNG['continueUpgrade']       = 'Обновить';
$LNG['login']                 = 'Войти в панель администратора';

$LNG['menu_intro']  на запись.';
$LNG['req_ftp_host']          = 'FTP хост';
$LNG['req_ftp_username']      = 'FTP логин';
$LNG['req_ftp_password']      = 'FTP пароль';
$LNG['req_ftp_dir']           = 'FTP путь к 2Moons';
$LNG['req_ftp_send']          = 'Установить права CHMOD 777';
$LNG['req_ftp_error_data']    = 'С предоставленными учетными данными не удалось подключиться к серверу FTP.';
$LNG['req_ftp_error_dir']     = 'Папка указана неверно.';

$LNG['step1_head']            = 'Настройка доступа к базе данных';
$LNG['step1_desc']            = '2Moons может быть установлена на Вашем сервере, но Вы должны указать настройки доступа к базе данных. Если Вы


[Effectiveness of integrative psychotherapeutic counseling for students].
In this first effectiveness study of psychotherapeutic counseling for students in German-speaking countries, the effectiveness of an integrative model of counseling was evaluated based on a sample of 151 clients. Effectiveness of integrative counseling according to the ABCDE-model was found to be high in comparison to other international studies in this area. Pre-post differences on measures of mental distress and satisfaction were significant and effect sizes were mostly moderate to high. A high percentage of clients improved statistically and clinically significant. Counselors' expert rating and diagnostics according to ICD-10 that have been included in contrast to previous effectiveness studies showed that clients suitable for the counseling setting get treated in the counseling center while more severely disturbed clients in terms of psychopathologyget out from under it he took 714,000,000 that he put in obamacare which will never get working and with the help of some other dummys in dc took some military retirement and he is not finished yet ex democrat...

Bobby Saunders

Tech8668

So leave, Paul; no great loss. Attitudes like yours are why we are in the mess we are in. What are we supposed to do: sit around and let this incompetent "president" totally destroy our country? He truly is the worst ever and the most dangerous. Wake up.

Rich Mullin

If you quit the Legion , stay off the page. Seems there are a few other infiltrators turning it into a childish social media outlet. I agree this administration , voted in twice ,just as another Chancellor was democratically elected


schools when coming from dirt poor family. The sale of his books sure didn't make him all that he is worth today. No wonder he hired a team to keep his records sealed and never revealed his college transcripts. To this date i have never witnessed anyone coming forward and saying I knew him when he was growing up and his classmates stroies while he was in all of his schools. Wonder why that is? He has done more to create more strife and destroy the constitution than any other president ever. I can see the museum now for this poor excuse for our leader in the future being full of lies and smoke and mirrors his support of breaking our nations laws and rules.

Perry McClendon

"If Congress won'tact, I will. I have a pen and a phone---". That's exactly why our founding Fathers wrote in to our Constitution a balance of powers. This president has trampled the Constitution and spit on the portrait of our Founding Fathers. His unending rhetoric is full of lies and distortion. There was nothing in his State of the Union speech that addressed the state of the union. It was another campaign speech full of empty promises to those who worship at is feet.
Indeed,,, Jimmy Carter must be proud of this guy !!!!

George B

You're the only one that I have seen bring race into it. Same old crap, if a person doesn't agree with something he must be a racist. Carter sucked as President and so does Obama. Not racist


a democracy can gain concensus agreement. His speeches are loved by those who hug and kiss this guy. Wasn't that absolutely ridiculous the way he hugged and kissed every Congressional woman, and even the Supreme Court women? I was shocked and appalled by this outrageous display of public affection. I was totally embarrassed that his highness would carry on this way. Absolutely shocking!!!

Jim Blondin

Our imperial President thinks and acts like a dictator. He makes you think that he wants to work with legislators, but he really has nothing but scorn and contempt for them. It's his way or the highway. Just look at how he has rammed his legislation through Congress, while it was in recess. Just look at the number of Executive Orders he has issued. Hebypasses the legislative process when the majority of American people speak their voice. His highness thinks he is a great leader, but a great leader in a democracy can gain concensus agreement. His speeches are loved by those who hug and kiss this guy. Wasn't that absolutely ridiculous the way he hugged and kissed every Congressional woman, and even the Supreme Court women? I was shocked and appalled by this outrageous display of public affection. I was totally embarrassed that his highness would carry on this way. Absolutely shocking!!!

Forest Webb

It is a shame that so many people now disrespect the office of the President. I thought it was about time the President took exception to the Congress. He has tried to work with them to no avail. I


wouldn't be getting their fine benefits any longer. He, indeed, has too much power for a president. God help our Nation.

Robert Noe

The people voted in the GOP in the House for a reason, to counter the Democrats and the President, they are of a different party that do not see eye to eye and it was the President who consitantly refused to listen to the GOP in the House. Further, the Senate leader refuses to bring up any bills sponsored by the GOP members,so the failure of the President to get anything done is his fault and the people spoke in 2010 to elect a GOP house to 'STOP' the Democrats. The people spoke no only to elect the President, but to elect the GOP house; thus, theydid the same. We are headed for a Muslim country as well as a communist type and we don't want that in America. Ia m a vet. of the Korean War era and I love America and I don't love what is happening to us with this president. We are a Christian nation no matter what he says. The polls prove we are an 86% Christian nation and that is a majority to me.

Howard Strobel

I agree with you R.J. Barr. I think that we are a Christian nation. I heard Mr. Obama and countless others use the phrase "God Bless America". I've heard it so often that it almost becomes meaningless and pointless. I believe God did bless America. If you would like to know is wrong with


was clear that Ben was not happy and that the other person was responding very calmly.

“What do we do?” Jones asked

I honestly didn’t know the answer, but I didn’t want to take these innocent civilians down with me. We quickly worked out our story. I coerced Jones into helping me and he took me to Athenos who was also forced to get involved. They only helped because they feared for their lives.

After a few more minutes of the one-sided angry exchange from the deck, the cabin door popped open and I could see Ben Simpsons legs descending the stairs back into the cabin.

“I just want to say that I am totally against this. Whatever happens from here is not my fault,” he said as he rejoined us inthe cabin.

I then saw a familiar brand of black loafers descending the stairs beneath the pant legs of a typical dark blue suit. Then the last person that I wanted to see emerged.

“Well, well. I’m sorry to crash the party. Would you girls like to fill me in?”

I hope you don’t mind me sending corrections each section. Is there somewhere else you might like me to send them? I really am enjoying Road Kill. I’ve just always had an eye for seeing something out of place. Sometimes, it drives my husband crazy when watching tv.


Q:

Preserve license comment in TypeScript compiled output

TypeScript compiler provides an option to remove or retain comments in the compiled JavaScript output.
What I need is the ability to remove all comments but to keep one specific comment that is in the beginning of the file containing the license text.
I am using the compiler from node.js code so a solution that works from code (and is not exposed via tsc).
I cannot just prepend the license text to the resulting file since that would invalidate the source mapping.

A:

In older versions of TypeScript you could do this with pinned comments like below:
/*!
 * Test
 */

These comments would still be present after compiling with --removeComments. This feature is gone/broken in TypeScript 1.4 but works again in the latest GitHub source code. So Iin Brighton, Johnson was a consistent for the Lady Cardinals. No matter if the coaches changed, or teammates left, Johnson was dependable. She is blessed with leaping ability.
Johnson has great hand and eye coordination. With her IQ for her sports, Johnson was usually in the right place at the right time. She go for 20 points in a basketball game or dropped several kills on a front line in volleyball.
I will miss watching Johnson and Fleming on a regular basis.

Most Likely to be a ComicEthan Dupree & Keyona Johnson
A good sense of humor is needed in sports. When things are going bad or get tough, a well-timed joke will ease the tension. And frankly, it will make this reporter’s day.
For years Millington’s Ethan Dupree and Keyona Johnson have


Guard tag checking */
	/* HBA error checking enabled */
	else if (IS_PI_UNINIT_CAPABLE(ha)) {
		if ((scsi_get_prot_type(GET_CMD_SP(sp)) == SCSI_PROT_DIF_TYPE1)
		    || (scsi_get_prot_type(GET_CMD_SP(sp)) ==
			SCSI_PROT_DIF_TYPE2))
			fw_prot_opts |= BIT_10;
		else if (scsi_get_prot_type(GET_CMD_SP(sp)) ==
		    SCSI_PROT_DIF_TYPE3)
			fw_prot_opts |= BIT_11;
	}

	if (!bundling) {
		cur_dsd = (uint32_t *) &crc_ctx_pkt->u.nobundling.data_address;
	} else {
		/*
		 * Configure Bundling if we need to fetch interlaving
		 * protection PCI accesses
		 */
		fw_prot_opts |= PO_ENABLE_DIF_BUNDLING;
		crc_ctx_pkt->u.bundling.dif_byte_count = cpu_to_le32(dif_bytes);
		crc_ctx_pkt->u.bundling.dseg_count = cpu_to_le16(tot_dsds -
							tot_prot_dsds);
		cur_dsd = (uint32_t *) &crc_ctx_pkt->u.bundling.data_address;
	}

	/* Finish the common fields of CRC pkt */
	crc_ctx_pkt->blk_size = cpu_to_le16(blk_size);
	crc_ctx_pkt->prot_opts = cpu_to_le16(fw_prot_opts);
	crc_ctx_pkt->byte_count = cpu_to_le32(data_bytes);
	crc_ctx_pkt->guard_seed = __constant_cpu_to_le16(0);
	/* Fibre channel byte count */
	cmd_pkt->byte_count = cpu_to_le32(total_bytes);
	fcp_dl = (uint32_t *)(crc_ctx_pkt->fcp_cmnd.cdb + 16 +
	    additional_fcpcdb_len);
	*fcp_dl = htonl(total_bytes);

	if (!data_bytes || cmd->sc_data_direction == DMA_NONE) {
		cmd_pkt->byte_count = __constant_cpu_to_le32(0);
		return QLA_SUCCESS;
	}
	/* Walks data segments */

	cmd_pkt->control_flags |=
	    __constant_cpu_to_le16(CF_DATA_SEG_DESCR_ENABLE);

	if (!bundling && tot_prot_dsds) {
		if (qla24xx_walk_and_build_sglist_no_difb(ha, sp,
		    cur_dsd,yet */
	tot_dsds = 0;

	/* Send marker if required */
	if (vha->marker_needed != 0) {
		if (qla2x00_marker(vha, req, rsp, 0, 0, MK_SYNC_ALL) !=
		    QLA_SUCCESS)
			return QLA_FUNCTION_FAILED;
		vha->marker_needed = 0;
	}

	/* Acquire ring specific lock */
	spin_lock_irqsave(&ha->hardware_lock, flags);

	/* Check for room in outstanding command list. */
	handle = req->current_outstanding_cmd;
	for (index = 1; index < req->num_outstanding_cmds; index++) {
		handle++;
		if (handle == req->num_outstanding_cmds)
			handle = 1;
		if (!req->outstanding_cmds[handle])
			break;
	}
	if (index == req->num_outstanding_cmds)
		goto queuing_error;

	/* Map the sg table so we have an accurate count of sg entries needed */
	if (scsi_sg_count(cmd)) {
		nseg = dma_map_sg(&ha->pdev->dev, scsi_sglist(cmd),
		    scsi_sg_count(cmd), cmd->sc_data_direction);
		if (unlikely(!nseg))
			goto queuing_error;
	} else
		nseg = 0;

	tot_dsds = nseg;
	req_cnt = qla24xx_calc_iocbs(vha, tot_dsds);
	if (req->cnt < (req_cnt + 2)) {
		cnt = RD_REG_DWORD_RELAXED(req->req_q_out);

		if (req->ring_index < cnt)
			req->cnt = cnt - req->ring_index;
		else
			req->cnt = req->length -
				(req->ring_index - cnt);
		if (req->cnt < (req_cnt + 2))
			goto queuing_error;
	}

	/* Build command packet. */
	req->current_outstanding_cmd = handle;
	req->outstanding_cmds[handle]


      ct_iocb->rsp_byte_count =
            cpu_to_le32(bsg_job->reply_payload.payload_len);
        ct_iocb->cmd_byte_count =
            cpu_to_le32(bsg_job->request_payload.payload_len);
        ct_iocb->dseg_0_address[0] = cpu_to_le32(LSD(sg_dma_address
            (bsg_job->request_payload.sg_list)));
        ct_iocb->dseg_0_address[1] = cpu_to_le32(MSD(sg_dma_address
           (bsg_job->request_payload.sg_list)));
        ct_iocb->dseg_0_len = cpu_to_le32(sg_dma_len
            (bsg_job->request_payload.sg_list));

	avail_dsds = 1;
	cur_dsd = (uint32_t *)ct_iocb->dseg_1_address;
	index = 0;
	tot_dsds = bsg_job->reply_payload.sg_cnt;

	for_each_sg(bsg_job->reply_payload.sg_list, sg, tot_dsds, index) {
		dma_addr_t       sle_dma;
		cont_a64_entry_t *cont_pkt;

		/* Allocate= 12 + 16 + 4;
		}

		cmd_pkt = (struct cmd_type_6 *)req->ring_ptr;
		cmd_pkt->handle = MAKE_HANDLE(req->id, handle);

		/* Zero out remaining portion of packet. */
		/*    tagged queuing modifier -- default is TSK_SIMPLE (0). */
		clr_ptr = (uint32_t *)cmd_pkt + 2;
		memset(clr_ptr, 0, REQUEST_ENTRY_SIZE - 8);
		cmd_pkt->dseg_count = cpu_to_le16(tot_dsds);

		/* Set NPORT-ID and LUN number*/
		cmd_pkt->nport_handle = cpu_to_le16(sp->fcport->loop_id);
		cmd_pkt->port_id[0] = sp->fcport->d_id.b.al_pa;
		cmd_pkt->port_id[1] = sp->fcport->d_id.b.area;
		cmd_pkt->port_id[2] = sp->fcport->d_id.b.domain;
		cmd_pkt->vp_index = sp->fcport->vha->vp_idx;

		/* Build IOCB segments */
		if (qla24xx_build_scsi_type_6_iocbs(sp, cmd_pkt, tot_dsds))
			goto queuing_error_fcp_cmnd;

		int_to_scsilun(cmd->device->lun, &cmd_pkt->lun);
		host_to_fcp_swap((uint8_t *)&cmd_pkt->lun, sizeof(cmd_pkt->lun));

		/* build FCP_CMND IU */
		memset(ctx->fcp_cmnd, 0, sizeof(struct fcp_cmnd));
		int_to_scsilun(cmd->device->lun, &ctx->fcp_cmnd->lun);
		ctx->fcp_cmnd->additional_cdb_len = additional_cdb_len;

		if (cmd->sc_data_direction == DMA_TO_DEVICE)
			ctx->fcp_cmnd->additional_cdb_len |= 1;
		else if (cmd->sc_data_direction == DMA_FROM_DEVICE)
			ctx->fcp_cmnd->additional_cdb_len |= 2;

		/*
		 * Update tagged queuing modifier -- default is TSK_SIMPLE (0).
		 */
		if (scsi_populate_tag_msg(cmd, tag)) {
			switch (tag[0]) {
			case HEAD_OF_QUEUE_TAG:
				ctx->fcp_cmnd->task_attribute =
				    TSK_HEAD_OF_QUEUE;
				break;
			case ORDERED_QUEUE_TAG:
				ctx->fcp_cmnd->task_attribute =
				    TSK_ORDERED;
				break;
			}
		}

		/* Populate the FCP_PRIO. */
		if (ha->flags.fcp_prio_enabled)
			ctx->fcp_cmnd->task_attribute |=
			    sp->fcport->fcp_prio


in MMT.

For routes of administration, the rates of injection (75.8 % vs. 75 %) and inhalation (24.2 % vs. 25 %) were similar among heroin users in TC and MMT.

The mean SDS score, number of substance related criminal convictions, number of non-substance related criminal convictions, and needle sharing rate were similar among heroin users in MMT and TC.

Prevalence of major depressive disorder and lifetime suicide attempts {#Sec9}
---------------------------------------------------------------------

Among MMT participants, the 1-month prevalence of major depressive disorder was 32.2 %. The lifetime prevalence of suicide attempts was 26.6 %. Among TC participants, the 1-month prevalence of major depressive disorder was 22.4 %. The lifetime prevalence of suicide attempt was 24.3 %.

Heroin users in MMT had a significantly higher 1-month prevalence of major depressive disorder compared to participants in TC (*p* = 0.019). MMT and TC participants had similar lifetime(CNN) Iowa Republican Rep. Steve King, an immigration hardliner, said Wednesday that Congress does not have to do anything to protect young immigrants who came to the country illegally as children. Instead, King said they can "live in the shadows."

"They continue to live the objective that they sought to achieve when they illegally entered America," King told reporters. "Live in the shadows."

King's comments came after the Trump administration announced Tuesday that it would end the Obama-era program known as DACA, Deferred Action for Childhood Arrivals, in six months. The delayed deadline is meant to give Congress time to find a legislative solution to protect DACA recipients from deportation, but some, like King, say that the group shouldn't expect Congress to act.

In an interview with CNN, King said that


forcing young immigrants to live in the shadows was "justice."

"Live in the shadows and if you get crossways with the law, then the law requires they be placed in criminal proceedings and go home. I think there's justice there, but we need to provide justice," King said.

House Speaker Paul Ryan, meanwhile, told his conference Tuesday morning that he was prepared to seek a legislative solution for DACA recipients if it was paired with border security.

"I think it's totally reasonable and appropriate that when you take a look at the DACA dilemma, this is a dilemma that in large part stems from the fact that it is a symptom of a larger problem, and the larger problem is that we do not have control of our borders. So it'sdrug trafficking organizations make in wholesale profits is around $39 billion annually. A dazzling figure that is within reach of those organizations that control the precious drug routes from Mexico into the United States.

THE WAR OVER $39 BILLION-DOLLAR-DRUG ROUTES

The U.S. Department of Justice says these billion-dollar-routes are controlled by seven main Cartels. Those are: The Sinaloa Cartel, Los Zetas, the Gulf Cartel, the Juárez Cartel, the Beltrán-Leyva Organization, La Familia Michoacana, and the Tijuana Cartel. Authorities view the Sinaloa Cartel as the preeminent organization because its members traffic all major illicit drugs, and its extensive distribution network supplies drugs to all regions of the United States. The Sinaloa Cartel is particularly dominant because it is one of the few Cartels that can obtain multi ton quantities of cocaine


Q:

Issue on Setting and Getting Global Variable in JavaScript - jQuery

Can you please take a look at this code and let me know why I am getting undefiend data type on printName();? So how we can update a global variable trough a function (like a Setter) function and get access the updated value via other functions if needed.
$(function () {
    var name;

    function setName() {
        name = "TestName";
    }

    function printName() {
        alert(name);
    }
    printName();
});

A:

Because you haven't set the name using setName(). function. in other words you never called setName()

             :   No. 2697 EDA 2017

             Appeal from the Judgment of Sentence March 21, 2014
    In the Court of Common Pleas of Philadelphia County Criminal Division at
                       No(s): CP-51-CR-0015280-2009

BEFORE: BENDER, P.J.E., STABILE, J., and MURRAY, J.

MEMORANDUM BY MURRAY, J.:                                 FILED MAY 06, 2020


  It is well-settled that the review of a trial court’s denial of a motion
      for a mistrial is limited to determining whether the trial court
      abused its discretion. An abuse of discretion is not merely an error
      of judgment, but if in reaching a conclusion the law is overridden
      or misapplied, or the judgment exercised is manifestly
      unreasonable, or the result of partiality, prejudice, bias or ill-will
      ... discretion is abused. A trial court may grant a mistrial only
      where the incident upon which the motion is based is of suchwill not be found based on a mere error of
      judgment, but rather occurs where the court has reached a
      conclusion that overrides or misapplies the law, or where the
      judgment exercised is manifestly unreasonable, or the result of
      partiality, prejudice, bias or ill-will.

Commonwealth v. Hicks, 151 A.3d 216, 224 (Pa. Super. 2016) (citations

omitted), appeal denied, 168 A.3d 1287 (Pa. 2017).

      As our Supreme Court has explained, generally, “all relevant evidence,

i.e., evidence which tends to make the existence or non-existence of a

material fact more      or    less probable, is admissible,


and highly prejudicial.

Id. at 141 (quotations and citations omitted).

      In this case, Victim accused Appellant of sexually assaulting her from

2001 through 2006, but she did not report the sexual abuse until 2009. See

N.T., 11/14/12, at 4, 10. To explain this delay, the Commonwealth sought to

introduce evidence that Appellant verbally and physically abused Victim while

they lived in the same house. N.T., 11/14/12, at 4. At trial, Victim testified

that Appellant verbally and physically abused her regularly for years, and that

the abuse included calling her a “bitch” and “ungrateful,” and hitting and

                                  book at which time a lightbulb went on over my head: that's Sandra Bullock's sister! Huh. That's kind of cool. What was even more awesome about the book was the easygoing writing style, the not-sugar-coated stories (despite the high volume of actual sugar involved), and surprisingly the wonderful recipes included in the book. I have quite a few of them bookmarked for future experimentation, but as is my nature I had piled that book back onto the great big pile of things I still need to do and promptly forgot about it again for way too long.

A little while ago I had decided to clean out my freezer and among all the other odds and ends I had found some leftover tart dough from a quiche I had


Rare-Earth Luminescent Material industry.
The report provides a basic overview of th...

The Global Rare Earth Phosphors Industry 2016 Market Research Report Enterprise Wide License is a professional and in-depth study on the current state of the rare earth phosphors industry.Firstly, the report provides a basic overview o...

The Global Rare-Earth Luminescent Material Industry 2016 Market Research Report is a professional and in-depth study on the current state of the Rare-Earth Luminescent Material industry.
Firstly, the report provides a basic overview of ...

Use our subscription option and keep yourself updated about the latest industry analysis reports. We have research reports for over 5000 micro markets; you can access and utilize them at economical budgets.sanctuary. Oliver lived out the remainder of his life in the care of the restructured Primarily Primates sanctuary.

Death
Oliver spent his last years with another chimpanzee, a gentle female known as Raisin.  She was placed with Oliver for companionship since Oliver's advanced age and years in the research lab left him arthritic, mostly blind, and unable to interact daily with younger, more playful chimps at the sanctuary.  News of Oliver as well as photos were often posted online by his caregivers, owing to public interest.  He took part in regular enrichment activities including a watermelon smashing party documented in the Friends of Animals online newsletter, and even the chance to paint.  Although elderly, Oliver had access to the outdoors and lived the rest of his


to different personalities. These are definitely wedding-registry worthy.

These patterns are offered in two placesetting options: a traditional five-piece or the new four-piece, which includes a dinner plate, a salad plate, all purpose bowl and a mug. These are manufactured here in the USA and they are dishwasher safe! Additionally, Lenox has a lifetime breakage replacement program. For more information, visit the breakage replacement portion of the Lenox website.

The Lifestyle Collection is now in stores. For more information on where you can find Lenox products, visit the store locator on the Lenox website.                              4
“[f]ollowing the 12-week AICM, there is a 17-week scheduled break during which students

remain fully enrolled.” Id. at 172. However, as Ross notes, Dasrath was not entitled to the

17-week scheduled break – the evident purpose of which was to permit students to study for the

Step 1 exam – because he failed the AICM course, and would have to retake it before taking that

exam.

        We have considered all of Dasrath’s remaining arguments and find them to be without

merit. Accordingly, for the foregoing reasons, the judgment of the district court is AFFIRMED.


---
title: チュートリアル:透過的なゲートウェイ経由でデバイス データを送信する - Azure IoT Edge での Machine Learning
description: このチュートリアルでは、開発用マシンをシミュレートされた IoT Edge デバイスとして使用し、透過的なゲートウェイとして構成されたデバイスを経由することで、IoT Hub にデータを送信する方法を紹介します。
author: kgremban
manager: philmea
ms.author: kgremban
ms.date: 6/30/2020
ms.topic: tutorial
ms.service: iot-edge
services: iot-edge
ms.custom: devx-track-csharp
ms.openlocfilehash: 78d3cbac28a85452f23e4a7c7ba3904fe3d1f488
ms.sourcegitcommit: 419cf179f9597936378ed5098ef77437dbf16295
ms.translationtype: HT
ms.contentlocale: ja-JP
ms.lasthandoff: 08/27/2020
ms.locfileid: "88997882"
---
# チュートリアル:透過的なゲートウェイを介してデータを送信する

> [!NOTE]
> この記事は、IoT Edge 上で Azure Machine Learning を使用するためのチュートリアルのシリーズの一部です。 この記事に直接アクセスしている場合は、最適な結果を得るために、シリーズの[最初の記事](tutorial-machine-learning-edge-01-intro.md) から始めることをお勧めします。

この記事でも、シミュレートされたデバイスとして開発用 VM を使用します。 ただし、データを IoT Hub に直接送信する代わりに、デバイスは、透過的なゲートウェイとして構成された IoT Edge デバイスにデータを送信します。

シミュレートされたデバイスがデータを送信している間、IoT Edge デバイスの動作を監視します。 デバイスの実行が終了したら、ストレージ アカウント内のデータを確認し、すべてが期待どおりに機能したことを検証します。

この手順は、通常はクラウドまたはデバイス開発者によって実行されます。

## デバイス ハーネスを確認する

[DeviceHarness プロジェクト](tutorial-machine-learning-edge-03-generate-data.md)を再利用して、ダウンストリーム (またはリーフ) デバイスをシミュレートします。 透過的なゲートウェイに接続するには、2 つの追加処理が必要です。

* 証明書を登録して、ダウンストリーム IoT デバイスが、IoT Edge ランタイムによって使用されている証明機関を信頼するようにします。 このケースでのダウンストリーム デバイスは開発用 VM です。
* エッジ ゲートウェイの完全修飾ドメイン名 (FQDN) をデバイス接続文字列に追加します。

これら 2 つの項目を実装する方法をコードで見てみましょう。

1. 開発用コンピューターで Visual Studio Code を開きます。

1. **[ファイル]**  >  **[フォルダーを開く...]** を使用して、C:\\source\\IoTEdgeAndMlSample\\DeviceHarness を開きます。

1. Program.cs の InstallCertificate() メソッドに注目します。

1. 証明書のパスが見つかったら、コードは CertificateManager.InstallCACert メソッドを呼び出して証明書をコンピューターにインストールすることに注意してください。

1. 次に、TurbofanDevice クラスの GetIotHubDevice メソッドを見てみましょう。

1. ユーザーが "-g" オプションを使用してゲートウェイの FQDN を指定すると、その値は `gatewayFqdn` 変数としてこのメソッドに渡され、これがデバイス接続文字列に追加されます。

   ```csharp
   connectionString = $"{connectionString};GatewayHostName={gatewayFqdn.ToLower()}";
   ```

## リーフ デバイスをビルドして実行する

1. DeviceHarness プロジェクトを Visual Studio Code で開いたまま、プロジェクトをビルドします。**[ターミナル]** メニューの **[ビルド タスクの実行]** を選択し、 **[ビルド]** を選択します。

1. Azure portal で IoT Edge デバイス (Linux VM) に移動し、概要ページから **DNS 名**の値をコピーして、エッジ ゲートウェイの完全修飾ドメイン名 (FQDN) を見つけます。

1. IoT デバイス (Linux VM) を起動します (まだ実行されていない場合)。

1. Visual Studio Code ターミナルを開きます。 **[Terminal]\(ターミナル\)** メニューから **[New terminal]\(新しいターミナル\)** を選択し、次のコマンドを実行します。`<edge_device_fqdn>` は、IoT Edge デバイス (Linux VM) からコピーした DNS 名に置き換えてください。

   ```cmd
   dotnet run -- --gateway-host-name "<edge_device_fqdn>" --certificate C:\edgecertificates\certs\azure-iot-test-only.root.ca.cert.pem --max-devices 1
   ```

1. アプリケーションは開発用コンピューターに証明書をインストールしようとします。 そのとき、セキュリティの警告を受け入れます。

1. IoT Hub 接続文字列の入力を求められたら、Azure IoT Hub デバイス パネル上の省略記号 ( **...** ) をクリックし、 **[Copy IoT Hub Connection String]\(IoT Hub 接続文字列をコピー\)** を選択します。 ターミナルに値を貼り付けます。

1. 次のような出力が表示されます。

   ```output
   Found existing device: Client_001
   Using device connection string: HostName=<your hub>.azure-devices.net;DeviceId=Client_001;SharedAccessKey=xxxxxxx; GatewayHostName=iotedge-xxxxxx.<region>.cloudapp.azure.com
   Device: 1 Message count: 50
   Device: 1 Message count: 100
   Device: 1 Message count: 150
   Device: 1 Message


hardware infrastructure will be deployed that will unify the imaging facilities, informational resources, and analytic capabilities into an organized and secure research platform. Key components will include DICOM data exchange services, an XNAT-based imaging informatics system, and integrated automated analysis pipelines. This infrastructure will be backed with expert consultation services, comprehensive documentation, and an extensive training program. 2. We will facilitate the transition of emergent imaging and analysis methods into production-grade research assets. A set of imaging methods have been identified that have associated anlysis methods that are at various stages in the development pipelines, including anatomic MRI;diffusion tensor imaging;positron emission tomography studies of flow, metabolism and radioligand binding;arterial spin labeling MRI;and quantitative blood oxygen level dependent (BOLD) MRI. Through an iterative process of optimizing, automating, and documenting,Emergy-based assessment on industrial symbiosis: a case of Shenyang Economic and Technological Development Zone.
Industrial symbiosis is the sharing of services, utility, and by-product resources among industries. This is usually made in order to add value, reduce costs, and improve the environment, and therefore has been taken as an effective approach for developing an eco-industrial park, improving resource efficiency, and reducing pollutant emission. Most conventional evaluation approaches ignored the contribution of natural ecosystem to the development of industrial symbiosis and cannot reveal the interrelations between economic development and environmental protection, leading to a need of an innovative evaluation method. Under such a circumstance, we present an emergy analysis-based evaluation method by employing a case study at Shenyang Economic and Technological Development Zone (SETDZ). Specific emergy indicators on industrial symbiosis,


ever being down and out. In March, he was sentenced to 90 days in jail for the naked trespassing incident. He will avoid jail time if he has a successful rehab and stays out of any legal trouble for 36 months.

It was clear that there seems to be something different about this particular recovery attempt. He's been to rehab countless times he said, but he seems to have taken a spiritual and personal left turn toward something better this time around. The change is more emotional and lifestyle-focused than simply trying to attain literal sobriety.

"When i made several attempts at recovery, I said 'I'm going to go get treatment and then I'm going to go back to my life,' and that never worked," he said. "Now my recoverymost recent arrest.

"We weren't necessarily kind to Todd at that point," Miller said. "Nobody said 'You're famous and we want to roll out the red carpet.' No we said you're going to have to do the work like every other Coyote. You're going to sign the code of conduct. If you're going to be a Coyote, you're going to go out in the community and you're going to walk the walk, not just talk the talk."

As Marinovich worked with quarterbacks and threw the ball around in practice, it became clear to Miller that Marinovich was starting to look like a former NFL player with the arm strength and the touch. The idea was hatched, but the big worry was not whether he would pass a drug test, but


current corresponding to global Poincaré (coordinate) transformations. Certainly, any diffeomorphism invariant action will also be globally Poincaré invariant, but there is no apparent need, a priori, to favor a certain subgroup. In our opinion, this is against the spirit of general relativity. (For instance, in general relativity with cosmological constant, the de Sitter subgroup is at least equally well justified.) For an illuminating discussion on this procedure, we refer to Ref. [@jackiw].

Let us also emphasize that, whenever we mention the canonical stress-energy tensor, we refer explicitely to the expression \[6\]. This is simply because it is directly related to the canonical formalism in quantum field theory (recall, e.g., the so-called canonical momentum $\partial  L / \partial
q_{,m}$ as well as the canonical construction of the Hamiltonian). Wenothing left with respect to which an eventual variation could be measured. Therefore, the value zero is as good as any other, and certainly better then the infinite values obtained, e.g., for the energy, in other theories, when gravity is not taken into account.

The tensor (\[24\]) and its relation to the Landau-Lifshitz tensor has also been discussed in Refs. [@6] and [@7]. The Belinfante symmetrization of the tensor (\[24\]) has been carried out in Ref. [@jackiw]. A different approach to the stress-energy of gravity can be found in Ref. [@8]. We would also like to point out an interesting paper by Padmanabhan[@9], dealing with the question whether general relativity can be obtained from a consistent coupling of the spin 2 field to the total stress-energy tensor, including its


spin-self interaction for spinor fields due to a non-dynamical torsion field[@10].

First, we define the gravitational stress-energy tensor as well as the spin density tensor in the following way $$\label{33}
T^i_{\ a} = - \frac{1}{e} \frac{\delta (e  L)}{\delta e^a_i}\ \ \
\text{and}\ \ \ \sigma_{ab}^{\ \ m} = \frac{1}{e} \frac{\delta (e L)}
{\delta  \Gamma^{ab}_{\ \ m}},$$ where $L$ is again the matter Lagrangian, with $S = \int e L {\mathrm{d}}^4 x$, where $e = \det (e^a_i) $.

We now derive the conservation law that results from the local Lorentz invariance. Consider an infinitesimal transformation (\[32\]), with $\Lambda^a_{\ b} = \delta^a_b + {\varepsilon}^a_{\ b}$ (${\varepsilon}^{ab}=-{\varepsilon}^{ba}$). The fields $e_m^a$ and $\Gamma^{ab}_{\ \ m}$ undergo the following change: $$\label{34}
\delta \Gamma^{ab}_{\ \ m} = - {\varepsilon}^{ab}_{\ \ ,m}- \Gamma^a_{\ cm}
{\varepsilon}^{cb} - \Gamma^b_{\ cm} {\varepsilon}^{ac}\ \gravitational field in the way of (\[24\]), with $g_{ik}$ replaced by $e^a_i$, is not possible in the case of matter fields coupling to the tetrad derivatives. Although one can derive the relation corresponding to Eq. (\[24\]), it is obviously not possible, in the second term, to replace $L_{tot}$ by $L_{grav}$, and thus to split the total stress-energy tensor into a matter and a gravitational part. This is one more argument in favor of an independent Lorentz connection and the first order formalism of Poincaré gauge theory.

This concludes our analysis of the relation between the canonical and the gravitational stress-energy tensors. Let us stress once again that even in those cases, where we have found *equivalence*, we have by no means *equality*. Especially, the canonical tensor is not even


= 0$), which is just the point where the stress-energy tensor is supposed to be of importance. This problem is, however, not hard to cure. One can simply replace the delta function by a more general density $\rho(x)$, still normalized by $\int \rho\ {\mathrm{d}}^3 x =1$.

More fundamental is the horizon problem. If the particle is still a black hole (i.e., if $\rho $ is still quite concentrated around the origin), then, we know from the Schwarzschild solution, that at the horizon, $g_{00}$ changes sign and becomes negative. This, however, is incompatible with the expression (\[66\]). Indeed, already from (\[64\]), we see that $g_{ik} v^i v^k$ should be positive, and thus, since inside the horizon, where the mass distribution is located, $g_{00} $ is negative, we cannot have $\vecv = 0$, i.e., the particle cannot be at rest. This might make sense for a test particle in the Schwarzschild field, but as far as the source itself is concerned, it is rather a contradiction.

Where is the origin of this problem? Well, it is not hard to see that the problem first occurs when we go from (\[61\]) to (\[62\]). One can then also guess the profound reason: At the horizon, $g_{00}$ and $g_{rr}$ change signs, which means essentially that $t$ becomes a spacelike and $r$ a timelike coordinate. This, however, does not mean that time becomes spacelike, but rather that $r$ takes over the role of the time coordinate and $t$ that of a space coordinate. Therefore, when we suppose the particle to be described by


interested in the time components. Integrating $T_D^{00} =
T^0_{D 0}$, we find $$\begin{aligned}
\label{86}
\int T_D^{00}{\mathrm{d}}^3 x
&=& \frac{1}{2} \int \left[\bar \psi \gamma^0 (i \partial_0 + e A_0)
\psi - \bar \psi (\overleftarrow \partial_0 - e A_0) \gamma^0 \psi
\right] {\mathrm{d}}^3 x
\nonumber \\
&=&
\frac{1}{2} \int\left[ \psi^{\dagger}
(i \partial_0 + e A_0)\psi - \psi^{\dagger} (\overleftarrow
\partial_0 - e A_0) \psi\ \right ]{\mathrm{d}}^3 x  \nonumber \\
&=& \int \psi^{\dagger}
(i \partial_0 + e A_0) \psi\ {\mathrm{d}}^3 x- \frac{{\mathrm{d}}}{{\mathrm{d}}t} \int \psi^{\dagger}
\psi \ {\mathrm{d}}^3 x.  \end{aligned}$$ The last term vanishes in view of the conservation law $(\bar \psi \gamma^m \psi)_{,m} = 0$, which follows from the Dirac equation (related directly to charge conservation). Therefore, using (\[84\]), we can write alternatively $$\label{87}
\int T_D^{00} {\mathrm{d}}^3 x = \int \psi^{\dagger} (H + e A_0) \psi\ {\mathrm{d}}^3 x.$$energy $- e A_0$ of the electron in the electric field, is not contained in the expression (\[87\]). This is in complete analogy with the classical case, namely the result (\[68\]) (together with the fact that there was no contribution from the interaction part, see (\[76\])).

Adding the stress energy-tensor (\[70\]) of the EM field (it is not hard to show that the same tensor emerges from a variation with respect to $e^a_i$ instead of $g_{ik}$), we find for the total energy $$\begin{aligned}
\label{88}
\mathcal  E &=& \int (T_D^{00} + T_{EM}^{00}) {\mathrm{d}}^3 x
\nonumber \\ &=& \int \psi^{\dagger}
(H + e A_0) \psi\ {\mathrm{d}}^3 x + \int \frac{1}{2}
(\vec B^2 + \vec E^2 ) \ {\mathrm{d}}^3 x  \nonumber \\
&=&
\int \psi^{\dagger} (\beta m + \vec \alpha \cdot (\vec p + e


a transverse component, $\vec E = \vec E_T + \vec E_L$, with $\vec \nabla E_L = \rho = j^0$ and $\vec \nabla E_T = 0$, then we recognize in (\[99\]) the well-know Hamiltonian used in QED in the form $$\label{100}
\int \tau_{EM}^{00} {\mathrm{d}}^3 x = \int \frac{1}{2}(\vec B^2 + \vec E^2_T) {\mathrm{d}}^3 x,$$ i.e., the non-propagating, longitudinal components of $\vec E$ are not contained in the electromagnetic part of the canonical stress-energy tensor. (The mixed terms $\vec E_T \cdot \vec E_L$ contained in $\vec E^2$ lead only to a surface term, while the longitudinal terms $\vec E_L^2$ just cancel against the four-fermion term in (\[99\]).) However, the same term appears again in the Dirac part of the canonical tensor (\[92\]) (see $H$ in (\[84\])). As a result, the total(as we will show below), in order to find a conserved energy. Apart from the free Maxwell Lagrangian, one will have to add the interaction part $\bar \psi e \gamma^m A_m \psi$, which will lead to quite a different interaction contribution in the stress-energy tensor.

However, we still have to show that this prescription really leads to a conserved energy definition. This is not hard to do. Consider a Lagrangian depending on two fields $q,p$, where $p$ is considered to be a background field. Thus, the free field Lagrangian for the field $p$ is missing. (Imagine, e.g., $q = (\psi, \bar \psi)$ and $p = A_i$ for the electron in a background electromagnetic field). Then, we have (flat limit) $$\label{102}
\partial_i  L  = \frac{\partial L}{\partial q} q_{,i} +


in general relativity, we need additional criteria to make a reasonable choice.

For simplicity, we consider first the case of Einstein-Cartan theory, with field equation $G^i_{\ k} = T^i_{\ k}$. Following Landau and Lifshitz, we write $$\label{a1}
\partial_i \left[e(-G^i_{\ k} + r^i_{\ k} + T^i_{\ k})\right]  = 0,$$ which is trivially satisfied if $r^i_{\ k}$ is a relocalization term, i.e., if we have $(e\  r^i_{\ k}) = r^{li}_{\ \ k,l}$, with $r^{li}_{\ \ k} =
r^{[li]}_{\ \ k}$. Then, we interpret $\tilde t^i_{\ k} = -G^i_k + r^i_{\ k}$ as stress-energy tensor of the gravitational field. In order to fix the relocalization term, Landau and Lifshitz choose the following two criteria: Firstly, $\tilde t^{ik}$ should be symmetric and secondly, it should not contain second and higher derivatives ofthe metric. (It turned out, in general relativity, that, in order to achieve both requirements, one has to replace $e = \sqrt{-g} $ by $e^2 =
-g$.)

We have already argued, at the end of section 4, that the first requirement does not make much sense in a general Poincaré gauge theory, since the matter part $T^{ik}$ is itself asymmetric. (This does not mean, however, that it is not possible, in principle, to symmetrize $\tilde t^{ik}$.) We therefore lift this requirement.

As to the second criteria, we see that already the choice $\tilde t^i_{\ k} =- G^i_{\ k}$ does not contain higher derivatives of the independent fields $(e^a_i, \Gamma^{ab}_{\ \ i})$. Thus, no relocalization is needed, and we can directly interpret $- G^i_{\ k}$ as stress-energy of the gravitational field.

In


other cases, the total stress-energy $\tilde t^i_{\ k} + T^i_{\ k}$ is zero throughout. Especially, outside of the matter distribution, there will be no gravitational energy density. This is rather disappointing, especially in view of potential applications concerning gravitational waves. However, in the absence of other criteria for the choice of $r^i_{\ k}$ in (\[a1\]), the choice $r^i_{\ k} = 0 $ is as good as any other and attempts to introduce an additional relocalization term in order to find a non vanishing energy density would be ad hoc and arbitrary. The only natural way to get a stress-energy tensor different from zero seems to be the canonical approach of section 4. The canonical tensor (\[51\]) has the additional advantage that $e^a_i$ and $\Gamma^{ab}_{\ \ i}$ are treatedthe concept of God for Santa.http://www.newseum.org/yesvirginia/

Good stuff pugowner. Of course Santa exists for those who believe in Santa, and have no other reason to believe otherwise. It is more about existence as a subjective thing, and less about what is real'. The child, having approached age 6 or 7, whatever, has not only read and sung about Santa, but seen a living apparition in the mall and onstage at school. As adulthood is reached, Santa's existence for the believer has been mitigated a tad, but not deleted, all assertions of "they lied to me" notwithstanding.

I think AlexF nails the issue. Belief acquisition and revision is about two things -- the evidence in favor of particular beliefs and the costs of being wrong. To paraphrase Popper, it is one


the world works, ghosts are exceedingly unlikely beasts (even less likely than pink non-magical unicorns). So our "prior" belief in them should be quite low, and the "evidence" presented in favor of them is quite *weak* so there is no good reason to revise to our beliefs to accept them.

If, though, you think that a belief in ghosts is not just "harmless" but for example "comforting," then if you are inclined to confuse the reasons for accepting a belief with the reasons for acting on it (when action matters) you might be tempted to believe in ghosts despite the bad evidence. This is especially true if it is belief itself that does the work, rather than an action taken on the basis of the belief.

So for example, Idihydroacetone phosphate.](fbioe-07-00389-g0001){#F1}

Here, we report the design of a functional non-phosphorylative synthetic cascade reaction to convert mannose obtained from SCG into the valuable platform chemical lactic acid (LA) ([Figure 1B](#F1){ref-type="fig"}). LA is a versatile chemical with a wide range of different applications in medical, textile and food industries and has received most of its attention for the production of the biodegradable polymer polylactic acid (PLA) (Dusselier et al., [@B15]; Castro-Aguirre et al., [@B10]). Key enzymes of the novel multi-enzyme cascade reaction include a newly identified mannonate dehydratase and a 2-keto-3-deoxygluconate (KDG) aldolase from the thermoacidophilic archaeon *Thermoplasma acidophilum*. The synthetic cascade reaction not only demonstrates an efficient conversion of mannose derived from SCG, but also indicates a possible mannose metabolism in *Thermoplasma acidophilum*.

Materials and Methods {#s2}
=====================

Reagents and Chemicals
----------------------

All chemicals


USA). All purified enzyme preparations were stored at −80°C.

Enzyme Assays
-------------

For all enzyme assays, reactions were performed in triplicates and all data were plotted and analyzed using Prism 6.0 (GraphPad software, La Jolla, CA). The enzymes AldT, KDGA and LDH were measured at 50°C and 20 mM NaP buffer pH 7.0. AldT kinetics were acquired for the substrate D-mannose, KDGA measured in the direction of aldol addition with pyruvate and glyceraldehyde as substrates and LDH for the substrate pyruvate. For all enzyme measurements one unit of enzyme activity was defined as the amount of enzyme necessary to convert 1 μmol substrate per minute.

AldT activity was assayed in reactions (800 μl) containing between 1 mM and 200 mM D-mannose and 5 mM NAD^+^ in 20 mM NaP buffer pH 7.0.the hydrolysate was filtered and 25 ml of the solution was neutralized by addition of CaCO~3~ until pH 6.0 was reached. The neutralized hydrolysate was washed and filtered through a 0.22 μm sterile filter. The monosaccharide concentration of the filtrate was analyzed by HPLC and quantified using a standard curve of mannose in ultrapure water. The amount of mannose present in SCG was quantified using the final mannose concentration in the hydrolysate corrected for losses observed with the STD. For the use of SCG hydrolysate in the cell-free reaction cascade, hydrolysates were concentrated using a rotational vacuum concentrator (Christ RVC 2-25 CD) to the desired concentration for the use in reaction cascade.

HPLC Analysis
-------------

LA yields were determined using an Agilent 1290 HPLC System (Agilent Technologies, Santa Clara, USA) connected


concentrations (25 and 50 mM mannose) at equal NAD^+^ concentrations ([Figure 2B](#F2){ref-type="fig"}). In reactions with 50 mM mannose, enhancing the ionic strength increased the LA yield from 2.6 ± 0.3 to 20.5 ± 0.5% of the theoretical maximum, while the LA yield slightly decreased in reactions with 25 mM mannose. This suggested that only at very high mannose concentrations (50 mM) acidification of the solution was limiting the production of LA. For the decrease in LA yield in reactions with up to 25 mM mannose, there must been another reason. Although no substrate inhibition was observed in single enzyme kinetic studies ([Figure S2](#SM1){ref-type="supplementary-material"}), it is possible that intermediates other than the natural substrate of each enzyme act as inhibitor.

![Effect of different mannose and cofactor concentrations on LA yield.**(A)** Reactions were performed in 0.1 M NaP buffer pH 7.0 with standard enzyme loading. **(B)** Effect of ionic strength on LA yield in reactions with high substrate concentrations. Reactions were performed with 25 and 50 mM mannose, equimolar NAD^+^ concentration and with standard enzyme loading.](fbioe-07-00389-g0002){#F2}

LA Production From SCG
----------------------

The feasibility of the cell-free reaction cascade for the conversion of biomass to LA was tested with sugars obtained from SCG. In order to substitute purposely-refined sugar as substrate, we obtained mannose directly from the galactomannan present in SCG. SCG was dried, subjected to a standard dilute acid hydrolysis procedure and analyzed regarding its mannose content by HPLC ([Figure 3A](#F3){ref-type="fig"}) (Sluiter et al., [@B45]). The mannose content of 100 mg SCG was found to be 28.7 ± 1.5 mg and


LA was produced from 14.57 ± 0.7 mM mannose (30.3 ± 1.5% yield of the theoretical maximum), whereas in reactions with pure mannose as substrate, 6.6 ± 0.1 mM LA could be produced from 13.9 ± 0.9 mM mannose (47.4 ± 3.9% yield of the theoretical maximum). Based on the concentration of mannose remaining compared to the amount of product formed, it was evident that a significant amount of mannose was not converted to LA in reactions from SCG. In contrast, mannose was almost completely oxidized in reactions with pure mannose. Further, metabolite analysis of the SCG hydrolysate and single enzyme assays in presence of hydrolyzed SCG could help to identify potential enzyme inhibitors in the mannose-rich waste resource.

Real-Time Tracking of the Cell-Free Reaction Cascade Using ^13^C NMR
--------------------------------------------------------------------

Monitoring      "value": "0"
          }],
          "valueName": "current",
          "mappingTypes": [{
            "name": "value to text",
            "value": 1
          }, {
            "name": "range to text",
            "value": 2
          }],
          "rangeMaps": [{


  "renderer": "flot",
          "seriesOverrides": [],
          "span": 9,
          "stack": false,
          "steppedLine": false,
          "targets": [{
            "expr": "rate(prometheus_local_storage_ingested_samples_total[5m])",
            "interval": "",
            "intervalFactor": 2,
            "legendFormat": "{{job}}",
            "metric": "",
    "percent",
          "gauge": {
            "maxValue": 100,
            "minValue": 0,
            "show": true,
            "thresholdLabels": false,
            "thresholdMarkers": true
          },
          "height": "180px",
          "id": 7,
          "interval": null,


 "isNew": true,
          "links": [],
          "mappingType": 1,
          "mappingTypes": [{
            "name": "value to text",
            "value": 1
          }, {
            "name": "range to text",
            "value": 2
          }],
          "maxDataPoints": 100,
               "lineColor": "rgb(31, 120, 193)",
            "show": false
          },
          "targets": [{
            "expr": "sum (machine_memory_bytes{instance=~\"^$instance$\"})",
            "interval": "10s",
            "intervalFactor": 1,
            "refId": "A",
            "step": 10
          }],


  "rgba(237, 129, 40, 0.89)",
            "rgba(245, 54, 54, 0.9)"
          ],
          "datasource": "${DS_PROMETHEUS}",
          "decimals": 2,
          "editable": true,
          "error": false,
          "format": "bytes",
          "gauge": {
            "maxValue": 100,
            "minValue": 0,
       "thresholdLine": false
          },
          "height": "200px",
          "id": 32,
          "isNew": true,
          "legend": {
            "alignAsTable": true,
            "avg": true,
            "current": true,
            "max": false,
            "min": false,


  "min": null,
            "show": false
          }]
        }],
        "showTitle": true,
        "title": "all pods"
      }, {
        "collapse": false,
        "editable": true,
        "height": "250px",
        "panels": [{
          "aliasColors": {},
          "bars": false,
               "height": "",
          "id": 17,
          "isNew": true,
          "legend": {
            "alignAsTable": true,
            "avg": true,
            "current": true,
            "hideEmpty": true,
            "hideZero": true,
            "max": false,


"threshold1": null,
            "threshold1Color": "rgba(216, 200, 27, 0.27)",
            "threshold2": null,
            "threshold2Color": "rgba(234, 112, 112, 0.22)"
          },
          "id": 16,
          "isNew": true,
          "legend": {
            "alignAsTable": true,
            "avg": true,
            "current": "total": false,
            "values": true
          },
          "lines": true,
          "linewidth": 2,
          "links": [],
          "nullPointMode": "null",
          "percentage": false,
          "pointradius": 5,
          "points": false,
          "renderer": "flot",
          "seriesOverrides": [],


         "current": {},
          "datasource": "${DS_PROMETHEUS}",
          "hide": 0,
          "includeAll": true,
          "label": "Namespace",
          "multi": true,
          "name": "namespace",
          "options": [],
          "query": "label_values(namespace)",
          "refresh": 1,
          "regex": "",
          row.setContentTransformationAmount(0, false /* isLastChild */);
        // It doesn't make sense to keep old animations around, lets cancel them!
        ExpandableViewState viewState = row.getViewState();
        if (viewState != null) {
            viewState.cancelAnimations(row);
            row.cancelAppearDrawing();
        }
    }

    public void removeNotification(ExpandableNotificationRow row) {
        int childIndex = mAttachedChildren.indexOf(row);
        mAttachedChildren.remove(row);
        removeView(row);


 }
    }

    public void updateChildrenHeaderAppearance() {
        mHeaderUtil.updateChildrenHeaderAppearance();
    }

    public void updateGroupOverflow() {
        int maxAllowedVisibleChildren = getMaxAllowedVisibleChildren(true /* likeCollapsed */);
        if (mUntruncatedChildCount > maxAllowedVisibleChildren) {
            int number = mUntruncatedChildCount - maxAllowedVisibleChildren;
            mOverflowNumber = mHybridGroupManager.bindOverflowNumber(mOverflowNumber, number, this);
            if (mGroupOverFlowState == null) {
                mGroupOverFlowState = new ViewState();
     }
            }
        }
        updateExpansionStates();
        return result;
    }

    private void updateExpansionStates() {
        if (mChildrenExpanded || mUserLocked) {
            // we don't modify it the group is expanded or if we are expanding it
            return;
        }
        int size = mAttachedChildren.size();


for (int i = 0; i < size; i++) {
            ExpandableNotificationRow child = mAttachedChildren.get(i);
            child.setSystemChildExpanded(i == 0 && size == 1);
        }
    }

    /**
     *
     * @return the intrinsic size of this children container, i.e the natural fully expanded state
     */
    public int getIntrinsicHeight() {
        int maxAllowedVisibleChildren = getMaxAllowedVisibleChildren();
        return getIntrinsicHeight(maxAllowedVisibleChildren);
    }

    /**
     *   // When the group is expanded, the children cast the shadows rather than the parent
            // so use the parent's elevation here.
            childState.zTranslation =
                    (childrenExpandedAndNotAnimating && mEnableShadowOnChildNotifications)
                    ? parentState.zTranslation
                    : 0;
            childState.dimmed = parentState.dimmed;


      || (mContainingNotification.isGroupExpansionChanging()
                && !mHideDividersDuringExpand);
        for (int i = 0; i < childCount; i++) {
            ExpandableNotificationRow child = mAttachedChildren.get(i);
            ExpandableViewState viewState = child.getViewState();
            viewState.applyToView(child);

            // layout the divider
            View divider = mDividers.get(i);
            tmpState.initFrom(divider);
           child.setClipBottomAmount(clipBottomAmount);
        }
    }

    /**
     * This is called when the children expansion has changed and positions the children properly
     * for an appear animation.
     *
     */
    public void prepareExpansionChanged() {
        // TODO: do something that makes sense, like placing the invisible views correctly
        return;
    }

    /** Animate to a given state. */
    public void startAnimationToState(AnimationProperties properties) {


    child.setFakeShadowIntensity(0.0f, 0.0f, 0, 0);
        }
        if (mOverflowNumber != null) {
            if (mNeverAppliedGroupState) {
                float alpha = mGroupOverFlowState.alpha;
                mGroupOverFlowState.alpha = 0;
                mGroupOverFlowState.applyToView(mOverflowNumber);
                mGroupOverFlowState.alpha = alpha;
               mNeverAppliedGroupState = false;
            }
            mGroupOverFlowState.animateTo(mOverflowNumber, properties);
        }
        if (mNotificationHeader != null) {
            mHeaderViewState.applyToView(mNotificationHeader);
        }
        updateChildrenClipping();
    }

    public ExpandableNotificationRow getViewAtPosition(float y) {
        // find the view under the pointer, accounting for GONE views
        final int count = mAttachedChildren.size();
        for (int childIdx


   return mCurrentHeader;
    }

    private void updateHeaderVisibility(boolean animate) {
        ViewGroup desiredHeader;
        ViewGroup currentHeader = mCurrentHeader;
        desiredHeader = calculateDesiredHeader();

        if (currentHeader == desiredHeader) {
            return;
        }

        if (animate) {
            if (desiredHeader != null && currentHeader != null) {
                currentHeader.setVisibility(VISIBLE);
      false /* likeGroupExpanded */);
                child.setActualHeight((int) NotificationUtils.interpolate(singleLineHeight,
                        childHeight, fraction), false);
            } else {
                child.setActualHeight((int) childHeight, false);
            }
        }
    }

    public float getGroupExpandFraction() {
        int visibleChildrenExpandedHeight = showingAsLowPriority() ? getMaxContentHeight()


         false /* likeHighPriority */);
    }

    public int getCollapsedHeightWithoutHeader() {
        return getMinHeight(getMaxAllowedVisibleChildren(true /* forceCollapsed */),
                false /* likeHighPriority */, 0);
    }

    /**
     * Get the minimum Height for this group.
     *
     * @param maxAllowedVisibleChildren the number of children that should be visible
     * @param likeHighPriority if the height should be calculated as if it were not low priority
     */
    private int getMinHeight(int maxAllowedVisibleChildren,    mNotificationHeaderLowPriority = null;
        }
        recreateNotificationHeader(listener, mIsConversation);
        initDimens();
        for (int i = 0; i < mDividers.size(); i++) {
            View prevDivider = mDividers.get(i);
            int index = indexOfChild(prevDivider);
            removeView(prevDivider);
            View divider = inflateDivider();
            addView(divider, index);


Monday, March 31, 2014

Daniel Wallace reviews Blomberg's Can We Believe the Bible

3 comments:

First of all, allow me to express my gratitude to Daniel Wallace for introducing me to a new word - athetize. Love it! Will have to find ways to use it in future conversation.

The article is interesting. I find it shocking that people would get so upset about varying texts to the point that they would abandon the Faith. But trusting his data to be true, then it is an issue that deserves to be dealt with.

But heck, even St. Jerome had to deal with variant texts way back in his day. For instance, after several unsuccessful attempts, he gave up any hope of reconciling the various differences between different manuscripts of the Book of Psalms,1. Field
Embodiments relate to a pixel and an organic light emitting display device, and more specifically, to a pixel that is useful for implementing high resolution and high frequencies, and an organic light emitting display device using the pixel.
2. Description of the Related Technology
Various flat panel display devices that have advantages over cathode ray tubes, that is, the weight and size, have been developed. Flat panel display devices, liquid crystal display devices, field emission display devices, plasma display panels, and organic light emitting display devices have been proposed.
The organic light emitting display devices display images using OLEDs (organic light emitting diodes) that generate light by recombination of electrons and holes.
The field of application of such organic light emitting display devices has increasingly expanded to include PDAs, MP3 players,


mobile phones, etc. due to various advantages, such as high color reproduction and a small thickness.
The organic light emitting diodes used for the organic light emitting display devices include an anode electrode, a cathode electrode, and a light emitting layer formed therebetween. The organic light emitting diode emits light, when electric current flows from the anode electrode and the cathode electrode, and the amount of emitted light changes in accordance with changes in the amount of electric current, such that luminance is controlled.
FIG. 1 is a circuit diagram illustrating a pixel employed in some light emitting display devices. Referring to FIG. 1, the pixel includes an organic light emitting diode OLED, a first transistor T1, a second transistor T2, a third transistor T3, a fourth transistor T4, ahave blunted neurocardiovascular transduction we assessed the relationship between spontaneous bursts of sympathetic nerve activity (SNA) and fluctuations in mean arterial blood pressure and R-R interval. Resting SNA, blood pressure and ECG were obtained in pregnant (third trimester, n = 18) and non-pregnant (n = 18) women matched for age and pre-/non-pregnant body mass index. Custom software modelled beat-by-beat pressure (photoplethysmography) and R-R interval in relation to sequences of SNA bursts and non-bursts (peroneal microneurography). Sequences were grouped by the number of bursts and non-bursts [singlets, doublets, triplets and quadruplet (four or more)] and mean blood pressure and R-R interval were tracked for 15 subsequent cardiac cycles. Similar sequences were overlaid and averaged. Peak mean pressure in relation to sequences of SNA was reduced in pregnant vs. non-pregnant


Average pump prices in Chicago are running higher, at $2.31 per gallon in the city and about $2.12 per gallon across the metro area. While Chicago gas prices are above the national average, it could be worse. It costs more to fill up on the West Coast and pockets of the East Coast, with California, for example, topping $2.72 per gallon, according to AAA.midfielder at the John Smith's Stadium.

He has already been linked with the likes of Newcastle United, West Ham United and Leeds United, while Watford and Southampton have now been added to the list.

For many, the rumour mill is already in full swing and has provided an insight into what lies ahead, so we have predicted the biggest transfer sagas for every Premier League club during the summer months:

Arsenal - Mesut Ozil

The highest earner in north London, Mesut Ozil only extended his deal last year but an exit from the Emirates Stadium continues to be mentioned as he has struggled to consistently find his best form - and there are suggestions Arsenal will sell if the right offer comes in.

The issue, however, is that Ozil’s wages provide a significant


next season but Aaron Mooy could earn a move to a side in the Premier League this summer after catching the eye in his two seasons in the top-flight with the Terriers.

Mooy has been linked with a move to Newcastle United and the Magpies are unlikely to be the only side in the running for the signature of the Australia international, who would prove to be a fine addition for a number of teams.

West Ham, Leeds United, Watford and Southampton are now said to be in the queue for his signatuture.

Leicester City - James Maddison

The 22-year-old has become one of English football’s hottest properties after excelling in his debut season in the Premier League with Leicester City, having arrived from Norwich City last summer, and he has notestablishing himself as a core member of West Ham’s side.

Pretty much all of the Premier League’s top-six have been linked with a move for his services and Rice may be tempted by a move despite the fact he only signed a new five-and-a-half year in December.

Wolves - Ruben Neves

Nuno Espirito Santo’s side have been phenomenal in the Premier League this season, proving themselves to be an extremely difficult opponent, and 22-year-old Portugal international Ruben Neves has been an integral part of their side.

Neves remains committed to Wolves but his services will certainly attract speculation this summer and it may be difficult for the club to spurn interest in his services should a significant offer be tabled - and there is a host of clubs across Europe who could


Date(s) : 05 January 1799

The last stronghold of the Neapolitans was the impregnable fortress of Gaëta. This was surrendered without a fight. The officers were allowed to go free but the men were prisoners of war 'enlisted' into the French army.India, especially in the Punjab region.

Other areas
The use of the suthan or the salwar has been adopted in other areas. People in Jammu have changed the traditional attire from the peshwaj (flowing to the ankles)  to the kurta and Dogri suthan.  In addition to the traditional lengha choli, women in Sindh wear the cholo (kameez) and suthan. The Punjabi salwar suit is also worn by many people. The Phiran in Kashmir traditionally flowed to the ankles, is now of varying lengths and is worn with a loose suthan. Kashyap Bandhu is regarded as the person responsible for spreading the use of the suthan with the phiran amongst the communities that resisted to adopt its use, eventually leading to the use of the salwar. However, the traditional


Ran is a small GTPase found in two nucleotide forms bound to GTP or GDP. Nucleotide exchange factors in the nucleus and GTPase activating proteins in the cytoplasm create a relatively high ratio of Ran-GTP to Ran-GDP in the nucleus, and an inverse ratio in the cytoplasm. Following entrance to the nucleus, importin-β1 binds to Ran-GTP causing a conformational change and release of the importin-α-NLS cargo [@pone.0020188-Vetter1]. The nuclear export process is also regulated by high levels of Ran-GTP in the nucleus and low levels in the cytoplasm. Proteins that are destined for export form a stable ternary complex with an exportin transport factor and Ran-GTP. Following transport to the cytoplasm, stimulation of Ran GTPase leads to release of cargo.

Regulation of transcription factor access to the nucleus provideslaser system ([Figure 2A](#pone-0020188-g002){ref-type="fig"}). The fluorescent signal from STAT3-PA-GFP occurred within seconds of laser stimulation, rapidly distributed within the cytoplasm, and initiated nuclear localization by 2 minutes. A steady-state level of nuclear fluorescence was reached following approximately 20 minutes.

![Time-lapse imaging with photoactivation or photobleaching reveals STAT3-GFP continuous nuclear import.\
**A**) Nuclear import of photoactivatable STAT3 (STAT3-PA-GFP). HeLa cells expressing STAT3-PA-GFP were serum-starved. A region in the cytoplasm (solid dot) was subjected to continuous high-intensity laser to photoactivate the cytoplasmic STAT3-PA-GFP and its nuclear accumulation was evaluated. **B**) Nuclear FRAP experiments were performed with cells expressing STAT3-GFP and serum-starved. A ROI in the nucleus was subjected to high intensity laser (black circle) to bleach nuclear STAT3-GFP. Nuclear fluorescence recovery was evaluated in untreated cells (control) or cells treated with IFNα.


of multiple experiments were performed with untreated or IFNα-treated HeLa cells or IL-6-treated Hep3B cells. The nuclear export rate of STAT3-GFP was similar in untreated or cytokine-treated cells with no statistically significant differences. A previous report indicated that intra-nuclear mobility of STAT3 increased following cytokine treatment [@pone.0020188-Huang1], and this might affect export. To determine if mobility of STAT3-GFP within the nucleus before and after cytokine stimulation influenced export, we performed a strip-FRAP within a limited area of the nucleus ([Figure S2](#pone.0020188.s002){ref-type="supplementary-material"}). In this assay a slower fluorescence recovery indicates slower mobility within the nucleus. Curve fitting analyses indicated a recovery half-time of approximately 0.74 seconds in untreated cells and 1.46 seconds in cytokine-treated cells. Assays with a DNA-binding mutant indicated the slower mobility of tyrosine phosphorylated STAT3-GFP correlatedThere was an overall lower level of oligomerization detected by FRET following tyrosine phosphorylation of the N-terminal deletion that may be due to transition kinetics from unphosphorylated monomer to phosphorylated dimer compared to unphosphorylated dimer to phosphorylated dimer. It may also reflect a lack of tetramer formation between phosphorylated dimers [@pone.0020188-Zhang1]. In any case, the nuclear import of STAT3 is independent of its phosphorylation and its dimerization.

The spatial and temporal localization of a protein within the cell can dictate its biological effects. Two studies have used cell fractionation to report STAT3 localization within mitochondria to regulate oxidative phosphorylation [@pone.0020188-Wegrzyn1], [@pone.0020188-Gough1]. This technique uses cell disruption and differential centrifugation to enrich for organelles, membranes, or soluble molecules. However, caveats include incomplete cell lysis, contamination with nuclei, and artificial protein


might imagine, the system wasn't without its issues. As Transit Toronto points out, a passenger heading east at Bay would have the choice of two different levels and run the risk of missing a train simply by virtue of being at the wrong platform when the train arrived. The same problem applied heading west at St. George.

Interestingly, a customer survey conducted at the time found those in favor and those against interlining were matched for numbers. Most simply didn't care one way or the other.

After just six months, the TTC decided to can interlining and stick with fully separate Yonge-University and Bloor-Danforth lines. The arrival of the Spadina line meant the second platform at St. George remained vital while Lower Bay was bricked up and abandoned when trainsstopped passing through.

Today, Lower Bay has an almost legendary reputation amongst those with an interest in lost Toronto landmarks. Though rarely seen by regular subway riders, signs of its existence are still evident to those who pay attention: the mis-matched green tile used to cover over the stairs from the current platform at Bay, and the weird light visible down the tunnel from a westbound train at Yonge are often the first clues.

Having an unused subway station hasn't been all bad for the TTC. TV crews and filmmakers often rent the space as a filming location--chances are if you've seen the TTC on film, it's represented by Lower Bay. The TTC even owns an alternative set of signs for the platform to make it look like a stop


p\<0.001), these two groups showed significant improvements over time. Furthermore, the non-concomitant group showed similar symptom improvements when compared to the concomitant group. We obtained these similar results when we reanalyzed the data of patients who did not receive concurrent antipsychotics.

In spite of these limitations, the major implications of this study are as follows: 1) Quetiapine is well-tolerated and effective for treating schizophrenia or schizoaffective disorder in the usual care setting; 2) Dosages of quetiapine above 750 mg/d may be more desirable than recommended dosages for some patients with schizophrenia or schizoaffective disorder.

This study was funded by AstraZeneka Korea.

![Disposition of participated patients in the study.](pi-7-128-g001){#F1}

![The estimated cumulative response rate of patients during 24 weeks follow-up using Kaplan-Meier method.](pi-7-128-g002){#F2}

######

Demographic characteristics of enrolled patients (N=821)

![](pi-7-128-i001)

Total number of patients: ^\*^N=775,are able to provide for their families. Now we're coupling the union-made, sweat-free dimension with organic cotton and a competitive price. And we have decent internal practices—recycled materials whenever possible, a tree donated with every online purchase to cut our carbon footprint, all that good stuff. As we move forward, we'll be able to do more.

What did you do before you started your green business? What motivated your entrepreneurship?

Adam: I was a slate-roofing contractor, which was pretty green too, actually. I discovered that if I treated my customers and my workers the way I would want to be treated, everybody wanted to come back and do business again the next day. I suspected this simple ethical proposition could have broader applications, and I started No Sweat to prove


things: do your homework, keep your credit strong, and forget about the "greatest good for the greatest number." Who really knows what the greatest good is? Loving your neighbor as yourself works just fine, as long as you define your neighborhood as the entire planet.

Q:I want to support no sweat apparel companies. However, I cannot find large sizes that enable that. My oldest son has a size 15 foot (He's 6'5") Where can a find less ordinary sizing? Thank you! Peace!— Carol Lynn

Adam: See the answer above.

Q:Hi, Adam. Two questions: 1) How did you locate your organic textile manufacturer? and 2) What did you mean when you answered "Don't try this at home!" to the question about advice for other green entrepreneurs just starting out?— Al

Adam: 1) Theyengaged an independent actuary to make an actuarial valuation of the assumed dividend expectancy represented by the outstanding partnership certificates. The detailed method of this valuation is not disclosed in the record but it appears that each certificate holder's interest had to be separately valued because of individual factors such as age and length of service which had to be taken into account in each case. The contract between Viscount Leverhulme and the executors and Margarine Union, Ltd., provided for the issuance to the Viscount and the executors of ordinary shares of Margarine Union, Ltd. plus an amount in preference shares of that company substantially equal to the aggregate actuarial valuation of the outstanding copartnership certificates. The exchange of the ordinary shares of Lever Bros. Ltd. for ordinary


did not constitute taxable income. According to the stipulation: "The parties agree that the petitioners correctly omitted from gross income reported for the years in which the partnership certificates were received any value with respect thereto." Had they received a bonus of corporate stock as additional compensation for their services, the value of the stock upon receipt would have been taxable as income in the year received (cf. Bogardus v. Commissioner, 1937, 302 U.S. 34, 58 S.Ct. 61, 82 L.Ed. 32); and this value would have become the basis of the stock in their hands, since it would be presumed that they had rendered in exchange services of equivalent worth. But the partnership certificates were quite different from corporate stock. They were non-transferable, had no capital or market

We want to welcome the hottest event of the year! Midsummer Fire Festival is here!

We are just warming up, but get ready to light this place up!

Let's start playing with fire as a Torch Juggler, then you can do a Burning Hot Pole Dance but if that is not hot enough for you, you can visit the bonfires to Honor them as a random act of kindle-ness or Desecrate them if you can't take the heat. You may earn some Burning Blossoms along the way.

You can also face Lord Ahune inside The Slave Pens, and unless the battle burns you up, you may get some fiery rewards.

Flame Keepers and Flame Wardens of Dalaran, have a Flametastic Event!


arm. Because reducing HH signaling promotes angiogenesis, the imbalance of epithelial and stromal elements might explain the clinical trial's failure. HH inhibitors were likely to result in a strong reduction in signaling, but they were metabolized and excreted between doses; thus, the possible key consideration to elevate the efficacy might be the HH inhibitor dosage \[[@CR55]\]. However, there is no clinical trial concerning the combination therapy in this field. SHH and Gli1 are independent prognostic factors for resected PDAC because a lower expression of Gli1 or SHH led to longer DFS and OS \[[@CR56]\]. Thus, HH signaling showed promise to become a diagnostic tool for APC, such as NF-κB expression, MMP9 expression, and Gli1 expression and guide therapies in the future.

### Therapies enhancing drug delivery {#Sec7}

PDAC is characterizedselective oral inhibitor of VEGFR-1, − 2 and − 3, showed an ineffective outcome in improving the survival in APC patients in phase II/III studies \[[@CR66]\]. The contrast between preclinical studies and clinical trials may be because experimental models are rich in vascularity and lack desmoplastic reaction. The promising outcome of phase II studies was not obtained in phase III studies likely because the design of phase II studies was non-randomized and single armed. Studies of anti-angiogenic agents/gemcitabine-based therapies have achieved no superiority in survival. However, because 35% of PDACs are of the angiogenic phenotype, it is possible that a subgroup of patients would benefit from antiangiogenic therapies \[[@CR67]\]. One hundred fifty-six patients enrolled in CALGB 80303 underwent detection for histidine-rich glycoprotein and complement factor H to predict the response


to bevacizumab. However, only histidine-rich glycoprotein was weakly associated with OS \[[@CR68]\]. Subsequently, three predictive biomarkers were discovered in the same group of patients. A low level of VEGF-D was a favorable factor to benefit from bevacizumab/gemcitabine, and Ang-2 and SDF-1 were favorable to the gemcitabine/placebo arm \[[@CR69]\]. The identification of survival-related biomarkers and discoveries of other involved angiogenic pathways may salvage the present dilemma.

### Metabolism {#Sec9}

Metabolic tumor burden evaluation mainly includes total lesion glycolysis and the metabolic tumor volume, which showed strong consistency with CA19--9 and clinical prognosis for resectable PDAC \[[@CR70]\]. Because the desmoplastic microenvironment results in hypoxia and jejuneness, PC cells metabolized 10 times more glucose than normal cells. Glucose deprivation leads to the development of mutations in genes in the KRAS pathways in PCin APC patients showed no clinical significance, while stable disease and a partial response were achieved with the addition of matuzumab to gemcitabine \[[@CR23]\].

Active immune responses could be interpreted as exposing the tumor antigen to stimulate tumor-specific immunity. A phase I/II study of the telomerase peptide vaccine GV1001 showed a survival benefit when combined with granulocyte-macrophage colony stimulating factor (GM-CSF) in unresectable PC \[[@CR78]\]. However, phase III studies of GV1001 plus classic chemotherapy failed to significantly prolong survival in unresectable PC compared with that in the chemotherapy-alone group (NCT00358566, TeloVac ISRCTN4382138). Pancreatic GVAX is composed of GM-CSF that is irritated by two allogenic pancreatic cancer cell lines, inducing T cells against PDAC antigens. A randomized phase II study was conducted using GVAX with low-dose cyclophosphamide (Cy) followed by