        {
                executionContext.Warning("The 'PREVIEW_ACTION_TOKEN' secret is deprecated. Please remove it from the repository's secrets");
            }

            // Clear the cache (for self-hosted runners)
            IOUtil.DeleteDirectory(HostContext.GetDirectory(WellKnownDirectory.Actions), executionContext.CancellationToken);

            // todo: Remove when feature flag DistributedTask.NewActionMetadata is removed
            var newActionMetadata = executionContext.Global.Variables.GetBoolean("DistributedTask.NewActionMetadata") ?? false;

            var        imagesToPull[setupInfo.Image] = new List<Guid>();
                            }

                            Trace.Info($"Action {action.Name} ({action.Id}) from repository '{setupInfo.ActionRepository}' needs to pull image '{setupInfo.Image}'");
                            imagesToPull[setupInfo.Image].Add(action.Id);


       if (imagesToPull.Count > 0)
            {
                foreach (var imageToPull in imagesToPull)
                {
                    Trace.Info($"{imageToPull.Value.Count} steps need to pull image '{imageToPull.Key}'");
                    containerSetupSteps.Add(new JobExtensionRunner(runAsync: this.PullActionContainerAsync,
                          ArgUtil.NotNull(downloadInfo, nameof(downloadInfo));
            ArgUtil.NotNullOrEmpty(downloadInfo.NameWithOwner, nameof(downloadInfo.NameWithOwner));
            ArgUtil.NotNullOrEmpty(downloadInfo.Ref, nameof(downloadInfo.Ref));

            string destDirectory = Path.Combine(HostContext.GetDirectory(WellKnownDirectory.Actions), downloadInfo.NameWithOwner.Replace(Path.AltDirectorySeparatorChar, Path.DirectorySeparatorChar), downloadInfo.Ref);
            string watermarkFile = GetWatermarkFilePath(destDirectory);
            if (File.Exists(watermarkFile))
            {
                executionContext.Debug($"Action '{downloadInfo.NameWithOwner}@{downloadInfo.Ref}' already downloaded at '{destDirectory}'.");
                return;


 // TODO: Deprecate the PREVIEW_ACTION_TOKEN
                authToken = executionContext.Global.Variables.Get("PREVIEW_ACTION_TOKEN");
            }

            if (!string.IsNullOrEmpty(authToken))
            {
                HostContext.SecretMasker.AddValue(authToken);
                var base64EncodingToken = Convert.ToBase64String(Encoding.UTF8.GetBytes($"PAT:{authToken}"));
                httpClient.DefaultRequestHeaders.Authorization = new AuthenticationHeaderValue("Basic", base64EncodingToken);
            }
}

        public string Description { get; set; }

        public MappingToken Inputs { get; set; }

        public ActionExecutionData Execution { get; set; }

        public Dictionary<String, String> Deprecated { get; set; }
    }

    public enum ActionExecutionType
    {
        Container,
        NodeJS,
        Plugin,
        Script,
        Composite,
    }

    public sealed class ContainerActionExecutionData : ActionExecutionData


a marketing strategy to promote local commerce.

For instance, when players visit a shop in the game, they could earn real rewards, like coupons or vouchers, to redeem at that same shop in-person, Springer explains.

Characters that never got a fair shake in the '90s are brought back to life in Springer's games.

He pitched the concept at a Fort Wayne SOUP event in May 2019. While he didn’t win the prize money, he says he received positive feedback from attendees and the event’s organizers.

“This is not just a video game,” Springer said at SOUP. “This is a groundbreaking, innovative marketing campaign to promote our city and every single business in it, locally and beyond.”

Neighborhoods like East State Village are featured in i heart pizza's video games.

More than anything, he hopesfFN and CLM have been shown to have a good negative predictive value in regards to imminent preterm birth \[[@CR4], [@CR5]\]. PAMG-1 is a 34-kDa protein found within amniotic fluid throughout pregnancy. Its concentration in amniotic fluid is greater than 1000-fold that found in normal vaginal secretions or maternal blood \[[@CR6]\]. Recently, a rapid slide test that uses immunochromatography methods to detect trace amounts of PAMG-1 in cervicovaginal fluid has been developed to detect the rupture of membranes; the sensitivity of this method ranged from 94.4 to 98.9%, while the specificity ranged from 87.5 to 100% \[[@CR6], [@CR7]\].

In this study, we investigated the presence of PAMG-1 in the cervicovaginal fluid of women with clinical evidence of preterm labour without membrane rupture. We then raised the question of whether


approval and consent to participate {#FPar3}
==========================================

Ethics committee of Umraniye Medical and Research Hospital. Written informed consent was obtained from each participant.

Consent for publication {#FPar4}
=======================

Not applicable.

Competing interests {#FPar5}
===================

The authors declare that they have no competing interests.

Publisher's Note {#FPar6}
================

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
online user at the interface (Autism360.org) is the immediate beneficiary of an organized medical database. Autism360 also presents treatment options based on the experience of cluster-mates based on proximity analysis. The semantics[@R7] underlying the database flow from the general acceptance of "spectrum" to refer to autism over the past decade at the same time as contrary efforts to make autism\'s definition precise. The dimensionality of "spectrum" is enlarged along two or more axes into which the granular data of Autism360\'s members are encoded. A three-dimensional portrait of all the data underlying this report is pictured in reference 7---showing 79 482 symptoms of 1831 parent-identified autistic children aged 2 to 18 years.

METHODS
=======

Autism360.org was established to serve individuals with ASD and their caregivers. The profile items of each individual are


itemize the count of each profile item for boys and girls (totals in the database were 1495 and 336, respectively). Thus, the table counts subjects who reported a particular profile item based on gender. As such, the count data lends itself to proportion analysis. A two-sample proportion test ([Figure 3](#F3){ref-type="fig"}) was employed to determine whether or not a statistical difference existed in the proportion based on gender. A normal approximation was used to compute a *z* score ([Figure 4](#F4){ref-type="fig"}) and a level of statistical significance. When the level of significance was equal or less than a *P* value of .05, it suggested that the difference between genders for a particular profile item was beyond random chance. In those cases where we suspected a violation in the use ofa normal approximation based on a low n, a Fisher\'s exact test was employed to compute an exact *P* value.

![The 79 482 profile items encoded as intersections among 39 systems and 42 functions from 1831 individuals aged 2 to 18 years from Autism360.\
Abbreviation: CNS, central nervous system.](gahmj.2013.003.g001){#F1}

![Subset of 52 725 profile items encoded as intersections among 6 systems and 8 functions from 1525 boys and 336 girls from Autism360.\
Abbreviation: CNS, central nervous system.](gahmj.2013.003.g002){#F2}

![A two-sample proportion test was employed to determine whether there was a statistical difference in the proportion based on gender for each of the 712 different profile items.](gahmj.2013.003.g003){#F3}

![Profile items were sorted by *z* value to produce a table showing the extremes of *P* values among females (pink) and males (blue).](gahmj.2013.003.g004){#F4}

We used statistical metrics as a means


published literature. The latter offers additional clues to the question how gender differences may arise from exposing cells outside the blood-brain barrier in the brainstem to environmental and gut-derived toxins. Links are offered by the words *proclivity*, *unmasking*, and *starving* that appear in the titles of research findings[@R13]^--^[@R15] by a team led by Robert S.B. Clark, MD, and the Safar Center for Resuscitation Research at the University of Pittsburgh, Pennsylvania. Their studies submitted cultured male and female neuronal and lymphoid cells to various stressors, which unmasked different proclivities in cell death (apoptosis) mechanisms. Simply put, male cells underwent injury and rescue in domains of sulfation, glutathione, and oxidative stress featured in the research of Jill James, PhD,[@R16]^,^[@R17] and Richard Deth, PhD.[@R18] In that domain, a vicious cycle ofto $\Omega^*$ in the $L^2({\mathbb{R}^N})$-norm of $u_{\Omega_n}$, that is $\|u_n-u\|_{L^2({\mathbb{R}^N})}$ tends to zero, where $u=u_{\Omega^*}$. Indeed, if $\Omega_n$ converges to a strictly smaller set, then equation (\[bd1\]) cannot hold by monotonicity of the energy $J$ and this would give a contradiction. Fix $t_n>1$ such that $$\phi(t_n \Omega_n)=t_n^{2\alpha +N}\int_{\Omega_n}g^2=1.$$ Then necessarily $t_n\to 1$. By minimality of $\Omega^*$, $J(t_n\Omega_n)=t_n^{N+2}J(\Omega_n)\geq J(\Omega^*)$.\
Plugging into (\[bd1\]) yields $$\label{bd2}
 J(\Omega^*)\left\lbrack\frac{1-t_n^{N+2}}{t_n^{N+2}}\right\rbrack \leq \lambda_n(|\Omega^*|-|\Omega_n|).$$ We divide both sides of (\[bd2\]) by $t_n^{N+2\alpha}-1=\int_{\Omega^*}g^2\left(\int_{\Omega_n}g^2\right)^{-1}-1$ and we get $$\label{bd3}
 \frac{t_n^{N+2}-1}{t_n^{N+2\alpha}-1}\left(-\frac{J(\Omega^*)}{t_n^{N+2}}\right) \leq
\frac{\lambda_n|\Omega^*\setminus\Omega_n|\int_{\Omega_n}g^2}{\int_{\Omega^*\setminus\Omega_n}g^2}.$$ Now obviously, we just need to prove boundedness far from 0, thus we can assume that we are outside a fixed ball $B(0,R)$ (this notion of local shape subsolution can be localized). Therefore, $$\dfrac{\int_{\Omega^*\setminus\Omega_n}g^2}{|\Omega^*\setminus\Omega_n|}\geq \min_{{\mathbb{R}}^N\setminus B(0,R)} g^2>0.$$ We pass to the limit $\lambda_n\to 0$ and $t_n\to 1$; since


of $g$ to be radial.

We present two stability results which are in fact corollaries of Theorem \[teomonot\]. More precisely, we consider two different kinds of distances of functions: in Proposition \[corollstab\] we ask $g$ to be *quasi radial* in the $L^{\infty}$ norm, while in Proposition \[propstab\] the distance between the function $g$ and a radial function is controlled in terms of the $\alpha$-homogeneous sublinear function $|x|^\alpha$. Notice that this latter is in fact quite natural since the space of $\alpha$-homogeneous functions is considered.

\[corollstab\] Let $g, h$ satisfy (\[assum\_g\]) with $\alpha>1$ and assume $h$ to be radial with $$| g(x)-h(x) |\le {\varepsilon},$$ for every $x\in{\mathbb{R}^N}$ and some ${\varepsilon}>0$. Let $\Omega$ be the solution of (\[ovfbp1\]) related to $g$, then there exist $R_{{\varepsilon}}>r_{{\varepsilon}}>0$ such that $B(O, r_{{\varepsilon}})\subseteq\Omega\subseteq B(O, R_{{\varepsilon}})$ withthe thesis.

\[propstab\] Let $g, h$ satisfy (\[assum\_g\]) with $\alpha>1$ and assume $h$ to be radial with $$| g(x)-h(x)| \le {\varepsilon}|x|^{\alpha},$$ for every $x\in{\mathbb{R}^N}$ and some ${\varepsilon}>0$. Let $\Omega$ be the solution of (\[ovfbp1\]) related to $g$. There exist $R'_{{\varepsilon}}>r'_{{\varepsilon}}>0$ such that $B(O, r'_{{\varepsilon}})\subseteq\Omega\subseteq B(O, R'_{{\varepsilon}})$ with $|R'_{{\varepsilon}}-r'_{{\varepsilon}}|=\mathscr{O}({\varepsilon})$.

As before we notice that the assumptions on $h$ implies that there exists a positive constant $k$ such that $h(x)=k|x|^{\alpha}$. Since the stress function of a ball $B(O,\rho)$ is of the form $u(x)=\frac 1{2N}(\rho-|x|^2)$, the solutions to (\[ovfbp1\]) related to $h+{\varepsilon}|x|^{\alpha},h-{\varepsilon}|x|^{\alpha}$ are $$u_+(x)=\frac{{r'_{{\varepsilon}}}^2-|x|^2}{2N}, \qquad u_-(x)=\frac{{R'_{{\varepsilon}}}^2-|x|^2}{2N},$$ with $r'_{{\varepsilon}}={\big(N(k+{\varepsilon})\big)^{-\frac 1{\alpha-1}}}$, $R'_{{\varepsilon}}={\big(N(k-{\varepsilon})\big)^{-\frac 1{\alpha-1}}}$, respectively.

Then, for every $\alpha>1$, it holds $\lim_{{\varepsilon}\to 0^+} r'_{{\varepsilon}}=\lim_{{\varepsilon}\to 0^+} R'_{{\varepsilon}}=(kN)^{-\frac 1{\alpha-1}}$, which entails the thesis. Notice that the value $r=(kN)^{-\frac 1{\alpha-1}}$, corresponds to the value of the radius of the ball


Analgesic effect of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in patients with chronic pain.
Previous pharmacological studies using animals indicated that a systemic administration of L-threo-3,4-dihydroxy-phenylserine (L-DOPS), a precursor of noradrenaline, induces an antinociceptive effect and an increase in the CNS level of noradrenaline which serves an inhibitory role at the spinal dorsal horn and the supraspinal pain afferent system. The aim of the present study was to investigate the analgesic effect of L-DOPS in patients with chronic pain. We selected 18 patients with various kinds of pain. In nine patients, L-DOPS (tablets) was orally administered and pain was assessed by the visual analogue scale (VAS) before and after the L-DOPS administration. Administration of L-DOPS resulted in dose-dependent analgesia. The maximum analgesia (VAS change: from 10 to 4.1 +/- 0.9) was observed 60Tim Abbott

Tim Abbott

CEO and President at Tiberious Energy

A

proven professional with strong leadership, technical and communication skills with a sound record of leading a diverse workforce to meet complex requirements from conception through implementation. Recognized for ability to motivate and lead people in extremely complex and demanding environments.


take another wild public swing.

Wow. I have never seen this many ad hominem attacks in one paragraph. You should be proud of how you have taken failure of logic and informal fallacy to dizzying new heights. Why argue for or against the article when you can just attack the author on a personal level? An author who you obviously have no clue about. Congratulations on creating a post that has reached an Olympic gold medal level of bullshit.

Mike, while I might appreciate that the above comment is overly personal and at the very least unsolicited advice, which will always get one in trouble, there is no way that you can label the above an example of an ad hominem. Ad hominems are, as you know, informal fallacies. Fallaciesmuch context…

Never mind. I just found out how to turn on subtitles from Netflix. I would like to delete the above comment now, but I don't know how! I will come back after I've watched the film (w/English subtitles) and offer commentary then…

It really doesnt matter who is he throwing stones at , Amma is not different from John Friend, she is not special, there is no reason why her motives and M.o shouldnt be questioned… And I think that is the point Julian is trying to make.

When I see her in Darshan I see nothing but a woman giving hugs and there really is no evidence that she is other than that…a woman being treated as a rockstar that gives hugs .

India is ranked 147 in the


wonder we now see before our eyes.

There's no shortage of cults. That by itself should be no cause for concern. Given that Amma's cult gives so much vis a vis social welfare, and offers a direction to so many vis a via self-development (Hinduism), what exactly is the problem except that one cult might not like some other cult?

How about this. Why not support social welfare without falsely portraying oneself as a semi-magical being. The hospitals still get built but the money is raised based on a message of truth instead of a message of lies.

My question to you is why support falsehood and some good works when we instead can support truthfulness and good works? The lies espoused by Amma and her ilk are not necessary. Theyand I learn a lot every time. It's money well spent.

Thank you, Prajna, for making Julian's point in the article as Julian's point needed to be make here, and for doing it so thoughtfully.

I noticed you did not address the fact that Amma and devotes as yourself promote here a semi magical being, instead of an ordinary but wealthy woman. You claim to have grown out of the infantile fantiasis of Amma but appear to fail to realize that those infantile fantasies are what hucksters such as Amma trade in day and day out. If you truly have grown out of your infantile fantasies then you would realize the truth that your time with Amma is wasted.

Where did I promote her as a semi magical being? Where does


she promote herself as a magical or divine being? Can anyone actually find a direct quote to support this claim? Again, Amma is not wealthy. The Embracing The World charity takes in large donations which are used solely in administering to a vast network of charitable activities all over the world. More money of every dollar goes directly to the beneficiaries because of the vast volunteer effort which is inspired by Amma's example. What wealth does Amma personally have? Everything has been donated.

Claiming to be an enlightened guru is the same as promoting oneself as a magical being.

The money donated is controlled by Amma. Controlling money is wealth.

I wouldn't have a problem with Amma if she only promoted herself as a nice person with a caring heart. Thisto speed you towards enlightenment and bypass many obstacles. Westerners don't understand this. And yes, there are literally thousands of cases of her transforming lives, including mine. Have you read the books of her life and the things she has done? Have you experienced the enormity of her love and power? Have you felt the impact of her Divinity upon your spirit and fallen to your knees? Obviously not. The egos in these posts are incredible. It's interesting to see that despite posting several times, my posts are never put up, only the ones that agree with the author and the Rolling Stone article, both of whom are lying to you. I've been there. I've seen her and I've felt the transformative power of her love. And yes,


toward the nip at the same velocity.
The chilled rolls 1 are structured such that cooling water may pass through the rolls.
Molten metal is fed to a space defined by the chilled rolls 1 and the side weirs 10 to form a molten metal pool 13.
Formation of the molten metal pool 13 and rotation of the rolls 1 which are being cooled cause the metal to solidify on the outer peripheries of the chilled rolls 1 so that the strip 2 is delivered downward via the nip.
The pinch rolls 4 are arranged downstream of the chilled rolls 1 and adjacent to a succeeding process to which the strip 2 is to be delivered.
An upper end of the enclosure 5 provides a sealing chamber 14 into and from which a"Could you get that?" "Why?" "Just because you're too lazy to get up off your tushy?" "All the people in the entire world that I would wanna talk to are right here." "Sucker!" "Hey, Joey!" "Hey, Pheebs." "Can you do me a favor?" "I forgot the pin to my ATM card." "Can you get it for me?" "Sure." "Where is it?" "I scratched it on the ATM machine on the corner." "So you're 5-6-3-9?" "That's it!" "Thanks." "Wanna talk to Chandler?" "Let me talk to him." "He didn 't believe in my movie  whichisabig mistake, because it is real." "Real." "Tribbiani, get back to work." "Break time's over." "Who was that?" "My stunt double." "He's getting too familiar for my taste." "I've tried to apologize." "If I


you did with London." "Ditch you?" "You were pregnant" "Great story. I'm going." "Listen, this weekend we're all gonna go to Las Vegas to surprise Joey!" "including me!" "Do you wanna go?" "I can take a couple days off work." "Of course you can take a couple days off, because this trip includes me!" "I've got a presentation tomorrow." "I can't miss that." "I've got tickets to the Van Gogh exhibit. I waited a year for this." "Art lover." "What?" "I said, "Art lover. "" "is that an insult?" "I don't know. I'm very tired." "Rach, maybe we can fly out Saturday?" "Sounds great." "I'll call the airlines." "That'll be nice to have the apartment to myself." "To walk around naked." "No, so I can be by myself."not sharing." "l knew you weren't okay with that." "So you're a gladiator!" "What's going on?" "Monica had lunch with Richard." "Dawson?" "But that would've been so cool!" "Her boyfriend Richard." "It meant nothing." "After all this time, how can you not trust me?" "When you go lunching with hunky men and don't tell me!" "You're right. I'm sorry." "I should've told you." "Thanks." "There we go." "Now I love Vegas." "I promise you next time I absolutely will tell you." ""Next time"?" "So close." "There won't be a next time." "You cannot see him again." "I cannot see him?" "You can't tell me what to do." "That's funny, I think I just did." "If you act like this, I won't be around you." "Fine." "Happy anniversary!" "Guys,


care how much you want it, okay?" "I am not gonna have sex with you in the bathroom!" "You know, in Roman times, this was more than just a hat." "Really?" "Yeah, sure, sure." "They would scrub the floors." "They'd use it to get the mud off their shoe." "Sometimes underneath the horse would get dirty." "So they would stick it right-- l can't believe this is how I'm spending my anniversary." "I'll take you someplace nice." "A guy tipped me $1 00." "He was playing blackjack for an hour and he won $5000." "Can you believe that?" "If I won $5000, I'd join a gym." "Build up my upper body..." "... andhitRichardfrombehind with a stick." "Wait!" "Why don't I just do what that guy did?" "I'll takeon a second." "Hello, Vegas?" "We would like more alcohol." "You know what else?" "We would like some more beers." "Oh, I forgot to dial." "That must be our alcohol and beers." "It's Joey!" "I love Joey!" "Oh, I love Joey!" "Joey lives with a duck." "Look, I need some help, okay?" "Someone has to convince my hand twin to cooperate." "I'll do it." "Whatever you need me to do, I'm your man." "Are you okay?" "Yeah." "Fine." "Thanks." "Hey, Rach?" "How you doing?" "I'm doing good, baby." "How you doing?" "Don't let her drink anymore." "Here's that macadamia nut." "No, something else." "So what do you wanna do now?" "I wanna get out of the room." "I really miss downstairs." "Okay, you know what?" "There is only


the MP and her family."

Mair had a "history of mental illness", he said, but "has had help".

And his half-brother Duane St Louis said he believed Mair "wouldn't hurt a fly".

"He's never expressed any views about Britain, or politics or racist tendencies," he said. "I'm mixed race and I'm his half-brother, we got on well."

Meanwhile, neighbours have described Mair as a "loner" who liked gardening but "kept himself to himself".

David Pickles, who has lived near Mair since 1975 said he "still can't believe" Mair has been arrested and that he did not know of any connection between his neighbour and Ms Cox.

He's just quiet. He kept himself to himself. He lived by himself. He's been on his own for about 20 years. David Pickles, neighbour

Another neighbour, who did notIt looks like “Pacific Rim 2” may explore the concepts of the Drift (a process pilots undergo before synchronizing with the Jaeger) and the portal more in depth than the first pic.

In an interview with the Wall Street Journal, director Guillermo del Toro teased that the two films are standalones that are part of one big spectacle.

“It was hard to create a world that did not come from a comic book, that had its own mythology, so we had to sacrifice many aspects to be able to cram everything in the first movie,” he said. “Namely, for example ‘the Drift,’ which was an interesting concept. [Then there was] this portal that ripped a hole into the fabric of our universe, what were the tools they were using? And


Yup. Truth is, that's all you really need to look at. Just establish a baseline that your total T levels can't exceed X amount. If they do, have them take a more advanced screening to see if that is just normal for that person. There are some dudes walking around with very high levels of test, naturally. However if you're rocking out 1800-1900 for total T you're using something.

I don't know this is physiologically possible, but I know a guy that was getting Dr prescribed test cyp and taking 300-400mg per week and was still testing at like 350-400. They had no explanation of where the hell it was going.easy cool at night. And one of my favorite ways to spend a summer night is relaxing under the stars while at the Hollywood Bowl. I enjoy it all.

My eclectic musical tastes may have been heavily influenced by the artists I listened to as a young person. My little aqua blue transistor radio rarely left my side.

And looking back to the List of Billboard Hot 100 number-one singles of 1966, the year I entered high school, reminds me that the songs most played included “The Sound of Silence” by Simon & Garfunkel, “We Can Work it Out,” by the Beatles, “Paint it Black,” by the Stones, and “Strangers in the Night” by Frank Sinatra.

Frank Sinatra? Yes, and daughter Nancy had a #1 that year, too–an eclectic assemblage, don’t


didn’t know of the connection between Herb Albert and Cat Stevens. Thanks for that. Cat Stevens was a cool cat! :cool:

Wow Debra, you really zinged my heartstrings with this one! The very first pop concert I ever attended was the TJB with Brazil 66 and the Baja Marimba Band (remember them?) at the Hollywood Bowl in September 1967. At the time I had a huge crush on Herb Alpert, so you have stirred up some wonderful memories.

I don’t think I ever saw Sergio Mendez again, although I’ve enjoyed his musical evolution over the years. I did see the TJB several more times and last saw Herb Alpert in Orange County in the late 90s. He was looking good then, and is still looking good now — although obviouslycould have removed based upon 28 U.S.C. § 1441(a). As discussed further below, however, this distinction does not affect the outcome of plaintiff's current motion.
[2]  The only case relied upon by plaintiff in seeking remand, Burnett v. Birmingham Bd. of Educ., 861 F.Supp. 1036 (N.D.Ala.1994), is clearly inapposite. The court expressly stated that it "[did] not find a nucleus of operative fact common to the state and federal claims" in the case. Id. at 1039 (emphasis added). Because the opposite is true here, Burnett is of limited, if any, value.
[3]  We note that some courts have held that remanding of the entire case is appropriate under § 1367(c)(2), notwithstanding the pendency of one or more federal claims. See, e.g., Administaff, Inc. v. Kaster, 799 F.Supp. 685,


689-90 (W.D.Tex.1992) (collecting cases). We believe that Kaster misreads the holding of Cohill, and that nothing in the language of either Cohill or § 1367(c) authorizes such a result. See Kabealo v. Davis, 829 F.Supp. 923, 927 (S.D.Ohio 1993) (disagreeing with Kaster). In any event, the principles of judicial economy which the Kaster court relied upon in remanding the entire case are not endangered in the present action. Palivos claims that he needs and could get an immediate ruling on Counts I and II from the state court. As discussed above, such a ruling would directly impact the future of his § 1983 claim, and would likely be entitled to preclusive effect in this court.
Wheat germ agglutinin binding sites in the adult mouse cerebellum: light and electron microscopic studies.
The binding properties of derivatized wheat germ agglutinin (WGA) have been examined in fixed tissue sections from the adult mouse cerebellum and also in axonal tracing paradigms following cerebellar injections. The aim of these studies is to begin to distinguish the roles different binding sites may play in generating diverse biological activities which lead to neuronal uptake and axonal transport of lectins or glycoconjugates. Vibratome sections from aldehyde-fixed cerebellum were incubated in N-[acetyl-3H] WGA or WGA conjugated to horseradish peroxidase (WGA-HRP). Sections from this in vitro binding paradigm and those from cerebellar pressure injection cases using those tracers (in vivo binding paradigm) were processed for light microscopic autoradiography, histochemistry, and electron microscopy. Blocking experiments


were also performed with various sugar haptens to confirm the binding specificity of these lectin preparations. Light microscopy of lectin binding patterns within the cerebellar cortex has revealed that both derivatized WGA preparations bind most intensely to the molecular layer. Within the deep cerebellar nuclei, binding is unique and produces a punctate delineation of cell bodies and dendrites. Electron microscopy revealed that these binding sites are associated with glial processes which abut the plasma membrane of deep nuclei cells. Cerebellar WGA-HRP injection sites contain labeled profiles involved in uptake and axonal transport of the labeled lectin (e.g., multivesicular and dense bodies) in addition to label associated with synapses, glia, undetermined components of the extracellular space, and neuronal plasma membranes. These sites are therefore presumed to possess a hightraded up 0.4% against the dollar and now trades at $104.94 or 0.01189250 BTC.

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About ParkByte

ParkByte (PKB) is a PoW/PoS coin


cells in *C. jejuni*-associated GBS. IL17, a signature cytokine produced by Th17 cells, may have synergistic effects with proinflammatory cytokines such as TNF-*α*, IFN-*γ*, and IL-1*β*. IL-17 was found in the sciatic nerves of the experimental autoimmune neuritis (EAN), and the accumulation of IL-17 was correlated with the severity of neurological signs \[[@B81]\], which suggested a pathological contribution of IL-17 to the development of EAN. The frequency of Th17 cells in cerebrospinal fluid (CSF) and the level of IL-17 in plasma were detected significantly higher in active chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) \[[@B82]\] and furthermore, the levels of IL-17 and IL-22 in CSF were correlated with GBS severity \[[@B83]\]. Liang et al. \[[@B84]\] suggested that the TIM-3 pathway influences IL-17 release and Th17 and Th1 differentiation and theirB, and other vaccinations. The symptoms of GBS typically start within one day to several weeks following vaccination but usually peak around 2 weeks after the shot is given. Vaccine-induced GBS was first observed within 6--8 weeks of receiving the "swine flu" vaccine during influenza vaccination program in 1976-1977 \[[@B118]--[@B120]\]. Further subsequent studies suggested that "GBS is more strongly associated with vaccination for influenza" than for any other vaccine, but the exact reason for this association remains unknown. Analysis of vaccine program during 1993-1994 in USA accounted a slightly increased risk of GBS within the 6 weeks after immunization \[[@B121]\]. A more recent study also showed that influenza A (H1N1) 2009 monovalent inactivated vaccines were associated with a small increased risk of GBS. This finding translated to about


Furthermore, rabies vaccine prepared from the infected brain tissues of adult animals had an increased risk of inducing GBS due to the contamination with myelin antigens \[[@B127]\] but newer formulations of rabies vaccine, derived from chick embryo cells, do not appear to be associated with GBS at greater than the expected rate \[[@B123]\]. Comparisons with expected rates of GBS, however, were inconclusive for an increased risk, and lack of controlled epidemiological studies makes it difficult to draw conclusions about a causal association. Existing data for other vaccines are available based on isolated case reports or small groups related to immunizations, and no conclusion about causality can be drawn.

13. Conclusions and Future Directions {#sec13}
=====================================

*C. jejuni* infection is the predominant antecedent infection in GBS. It has been identified in 30%--50%product of the Farmer-Labor Party era in Minnesota, served as attorney for the newly organized Congress of Industrial Organization (CIO) unions in that state. In 1942 he came to Chicago as general counsel for the United Packinghouse Workers of America (UPWA) and later served as its International President from 1946 to 1968. Under Helstein's leadership, the UPWA was noted for its major gains for packinghouse workers and for its commitment to civil rights. He was also an ardent supporter of Highlander Center, a grassroots training center in rural Tennessee. In his later years he joined Michael Harrington and others on the board of the Democratic Socialist Organizing Committee.

Beatrice Hepp

(1895-1899) Grave 27, Sector A

A few yards from the Haymarket Monument is a headstone which reads Hepp and Hartman. There


surgery. Because gastric bypass is less effective in reducing serum LDL cholesterol levels and systolic blood pressure to the targets established by the triple end point of <100 mg/dL for LDL cholesterol and 130 mm Hg for systolic blood pressure, we decreased the estimated success rate for the gastric bypass group from the 83% that was set by Schauer et al to 65%. The other reason we lowered the estimated success rate is because the participants in our study had higher HbA1c levels than did the patients involved in the study by Schauer et al. Establishing the 30% success rate in the lifestyle-medical management group was based on studies used to generate the American Diabetes Association Standards of Care.13,16 This alternative hypothesis resulted in a sample-size estimate ofreports serving on an advisory board for Vivus and receiving institutional grant support from Aspire Bariatrics. Dr Bantle reports receiving institutional support for the Look AHEAD study. No other authors reported disclosures.

Funding/Support: The Diabetes Surgery Study was supported by Covidien, Mansfield, Massachusetts. Covidien provided funds for these 5 clinical locations: University of Minnesota, Minneapolis; Mayo Clinic, Rochester, Minnesota; Columbia University, New York, New York; National Taiwan University Hospital, Taipei, Taiwan; Min-Sheng General Hospital, Taoyuan, Taiwan. This publication was supported in part by grant UL1 TR000040 and grant UL1 RR024156 to Columbia University both from the National Center for Advancing Translational Sciences, National Institutes of Health, formerly the National Center for Research Resources.

Role of the Sponsors: The sponsoring agency had no role in the collection, management, analysis, and interpretation


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Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, pleaseglutamine metabolism, are crucial for cancer cells to shed from a primary tumor, overcome the nutrient and energy deficit, and eventually survive and form metastases \[[@CR4]\].

Biomarkers can be employed for (early stage) diagnosis of cancer, prognosis (assessing lethality) and prediction 117 (of patient's response to treatment). Some PL have been described in the literature as potential biomarkers for cancer, among them the plasmalogens, a subclass of GPL \[[@CR5], [@CR6]\]. Plasmalogens were discovered accidentally in 1924 by Feulgen and Voit \[[@CR7]\] while staining sections of tissue with a nuclear dye that reacted with the aldehydes released by DNA acid hydrolysis \[[@CR8]\]. Structurally plasmalogens exhibit a vinyl ether at the *sn-1* position of glycerol, play several roles in cellular function and are an important component of the cellular plasma membrane


\[[@CR9]\]. Although the mechanisms of action for plasmalogens remain unclear, they are starting to receive medical interest as they are now being linked to Alzheimer's disease, Down syndrome, molecular signaling abnormalities and cancer. Plasmalogens are linearly correlated with metastases spreading in vivo*.* Therefore, they can be useful in the prognosis of the most frequently observed human cancers, particularly in pathological colorectal, breast, lung and prostate tissues.

Among the organ cancers, gastrointestinal (GI) cancers present an interesting pattern in their global distribution. GI cancers is a term for the group of cancers that affect the digestive system and includes gastric, colorectal, intestinal, hepatocellular, esophageal and pancreatic cancers \[[@CR10]\]. According to the World Health Organization \[[@CR11]\], in 2015 cancer caused 8.8 million deaths worldwide. Among the types of cancer deaths, theFurthermore a better understanding of plasmalogen biology in cancer could also lead to the development of better diagnostic and prognostic biomarkers or new therapeutic targets for GI cancers.

The lipids in the human body {#Sec2}
============================

In the last decades there has been an intense effort to develop adequate methodologies to discover, identify and quantitatively monitor the lipids of the biological system \[[@CR16]\]. They have several key biological functions, such as the activation of the components of the cell membranes, and they serve as a source for energy storage and participate in the autocrine and paracrine signaling pathways and autophagy \[[@CR17]\]. This diversity of function is due to the enormous variation and complexity in the structure of their molecules since different biochemical transformations are necessary for their biosynthesis to occur \[[@CR18]\].

The


enzymes might be involved in the generation of lipid second messenger systems such as prostaglandins and arachidonic acid that are important in signal transduction \[[@CR56]\]. Ether lipids can also act directly in cell signaling, as the PAF is an ether lipid signaling molecule that is involved in leukocyte function in the mammalian immune system \[[@CR57]\].

Plasmalogens play a crucial role as endogenous antioxidants, protecting other PL, lipid and lipoprotein particles from oxidative stress \[[@CR48]\]. This is due to the fact that the vinyl ether bond is preferably oxidized, while protecting the polyunsaturated fatty acids present in the *sn-2* oxidation position \[[@CR55]\]. As the hydrogen atoms adjacent to the vinyl ether bond have relatively low dissociation energy, they end up being oxidized when exposed to various oxidizing reagents (peroxyl radicals,metal ions, UV light, singlet oxygen and halogenating species) \[[@CR58]\]. Consequently there is consumption of plasmalogens in the reaction and the polyunsaturated fatty acids and other membrane lipids are spared from oxidation, suggesting the role of sacrificial oxidant for plasmalogens \[[@CR7]\]. They undergo oxidative decomposition more readily than their fatty acid ester analogues \[[@CR59]\]. The oxidative products of plasmalogens are unable to further propagate lipid peroxidation; they may terminate the lipid oxidation process \[[@CR60]\]. Thus, it is suggested that plasmalogens interfere in the propagation step rather than in the initiation of lipid peroxidation \[[@CR61]\]. The product profile resulting from oxidation of plasmalogens will depend on the type of fatty acid esterified in the *sn-1* and *sn-2* positions of glycerol and on the nature of oxidative stress initiators \[[@CR59]\].


a given lipid can be differentiated by phosphorus nuclear magnetic resonance spectroscopy (^31^P NMR) \[[@CR76]\]. Analysis of the tissue phospholipid extracts by ^31^P NMR was found to be capable of discriminating between esophageal cancer and adjacent normal tissues, including the non-involved esophagus and normal stomach \[[@CR77]\].

Plasmalogen lipids in gastrointestinal cancer {#Sec10}
=============================================

Decades ago it was observed that cancer cells have remarkably higher levels of alkyl and alk-1-enyl ethers lipids compared to normal cells \[[@CR78]--[@CR81]\]. Encouraged by these findings, there were efforts trying to establish ether lipids as tumor markers in medical cancer diagnostics. Some studies have also reported decreased amounts of ether lipids in cancer patients \[[@CR75], [@CR77]\].

In Table [2](#Tab2){ref-type="table"} it is possible to evaluate some plasmalogens that were identified in colorectal, gastric, pancreatic and esophageal cancer patients as wellpatients \[[@CR94]\]. Recently, a lipidomics study on breast cancer patients identified increased plasma ether-linked phosphatidylcholine species as a diagnostic marker for breast cancer \[[@CR95]\]. Compared to that found in benign patients, the plasma concentration of LPC and CE were observed to decrease in cancer patients, while PC and ether-linked phosphatidylcholine were increased. The results showed that lipid profiles may be a promising avenue for the investigation of diagnostic biomarkers of breast cancer.

Opposing trends are observed in ovarian cancer. Hou et al. \[[@CR96]\] described that the epithelial ovarian cancer patients have reduced levels of plasmalogens compared with benign ovarian tumors and normal controls. The decreased PC and PE plasmalogens levels in these patients suggested that most cancer cells might exhibit elevated oxidative stress, which is consistent with previous findings


 Phosphatidylethanolamine

PG

:   Phosphatidylglycerol

PI

:   Phosphatidylinositol

PL

:   Phospholipids

PLA2

:   Phospholipase A2

PS

:   Phosphatidylserine

TLC

:   Thin-layer Chromatography

**Electronic supplementary material**

The online version of this article (10.1186/s12944-018-0685-9) contains supplementary material, which is available to authorized users.

This work has been supported by grants from Fapesp (2016/11905-2) and Capes.

Funding {#FPar1}
=======

This work was supported by Fapesp (2016/11905-2) and Capes.

Availability of data and materials {#FPar2}
==================================

Not applicable.

POC and MCFM conception and design of research; POC and MCFM drafted of manuscript; POC, MCFM, GCM and DGP revised and approved final version of manuscript.

Ethics approval and consent to participate {#FPar3}
==========================================

Not applicable.

Consent for publication {#FPar4}
=======================

Not applicable.

Competing interests {#FPar5}
===================

The authors declare that they have no competing interests.

Publisher's Note {#FPar6}
================

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
at a fixed gear ratio with respect to it. The outer planets couple with the large sun gear and co-rotates with a fixed gear ratio with respect to it. Finally, the ring gear also couples and co-rotates with the outer planets in a fixed gear ratio with respect to them.

Planetary gear trains

In contrast to a Ravigneaux, a  simple planetary gear train has two concentric gears, one or more planets bridging the gap between those gears, and one arm carrying the planets.  Usually, the smaller diameter concentric gear has external teeth and is called a sun gear, and the larger concentric gear has internal teeth and is called a ring gear.  The carrying arm is usually called the planet carrier.  Planet gears are usually not


Gabriel Salinas-Jones was the last heavyweight fight in Strikeforce's full Heavyweight division. Two days after this event was held, Strikeforce announced the end of the division (save for Heavyweight Grand Prix Tournament finalists Josh Barnett & Daniel Cormier) due to a lack of depth, and six of the promotion's remaining heavyweight fighters were folded into the UFC shortly afterwards.

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The following is the reported payout to the fighters as reported to the California State Athletic Commission. It does not include sponsor money or locker room bonuses.
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To get part of the depends working you can look into how the html of the chooser is built in the file Mage_Widget_Block_Adminhtml_Widget_Chooser. By simply adding a hidden field with the id $element->getId() to the returned string of the function _toHtml the field itself with hide/show but the button for choosing will not as this is part of a different row in the table. Here you would have to update the javascript to deal with the structure. Luckly the $chooserId that is used to build the button appears to be derived from the element id and so this should be fairly simply to find via javascript.

would deprive the dispute resolution process of the expertise the legislature thought necessary to administer the terms of the medical assistance program and to draft the documents required to implement that system. We conclude that provider agreement disputes are within DHS' jurisdiction.
This conclusion regarding jurisdiction is also supported by the fact that a nursing home cannot collect funds from the state without participation in the medical assistance program, the administration of which the legislature has delegated to DHS. The provider agreement is a significant part of a nursing home's participation in the medical assistance program and its relation with DHS. By statute this agreement is drafted by DHS. Therefore, whenever a nursing home contests its payments under Minn.Stat. § 256B.50, subd. 1, that contest may involve the meaning


N.W.2d at 457). Appellant argues that
The facts which support [its] district court claims are [DHS'] breach of the Provider Agreements[[3]] by failure to notify[[4]] *788 [appellant] after May 14, 1982 of [DHS'] decision to cease its using of the "per diem" method[[5]] * * *.
We disagree.
Appellant's present and prior litigation both involve essentially the same evidence. Both cases involve the fact of the existence of the provider agreements, that after White Bear's termination of "per diem" pay back calculations the amount appellant owed DHS was calculated under the gross dollar method and that as a result of that "gross dollar calculation" appellant suffered damages. On these facts, we conclude that appellant's past and present claims involve the same cause of action under Hofstad and involve essentially the samea standout, none more so than “Ladbroke Grove”, a hat-tip to classic garage in which Tracey switches up his flow to emulate a Nineties MC. It’s a thrilling work. (RO) The 50 best albums of 2019 35) Caroline Polachek – Pang The former Chairlift frontwoman’s solo debut (at least, her first under her own name) is an eccentric, experimental delight – PC music by way of classical pop. The product of a divorce and a series of adrenal rushes she refers to as “pangs”, the album is musically agile and often lyrically stark: Sometimes I wonder/ Do I love you too much? Then I tell myself ‘Caroline, shut up’”, she sings on “Caroline Shut Up”. Polachek’s voice is her secret weapon – so jolting and elastic she had


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Free returns onsupport IE8/7 you should definitely considder using graceful degradation in this case. It is probably not worth the time and effort to strive for perfection everywhere. That is simply a goal which cannot be met when browsers will never get updated again.
1) What may be causing this
That is a fairly broad question, I couldn't reproduce the problem, or really find one in Chrome 20 (beta) so I will just list a things that can mess it up.

General browser rounding errors, browsers aren't precise, weren't designed to be precise sub-pixel
Mixing px values with other values, different roudings make values add up differently..
Positioning of in-flow elements which get influenced by other in-flow elements on the page (these are hard to track down usually)
Parent element properties (parents with overflow hidden, fixed


sizes, for example, I think this might be the problem here in the jsfiddle)
Bugs in browsers
Combination of the above

In this case jsfiddle has a crapload of containers and frames (with overflows set to hidden, fixed heights/widths, px based) etc on the page, even in 'full screen' view. So if you really want to make sure, make a html file on your own pc open/test with that.
2) In general, what makes layouts zoom-sensitive (if any such general rule exists...)?
In todays browsers this may not be all that relevant because zoom functionality is often very advanced and can even scale full-px based layouts without much problems. The only real problem browser which is still used today is IE7. The zoom capability of IE7 is atrocious, and for that reasontypes of plasmonic structure integrated SNSPDs that are capable of maximizing the absorptance at 1550 nm wavelength, as well as to analyze the polarization contrast that can be achieved via these A-SNSPD type devices. In addition to this we have analyzed tendencies in configurations of four corresponding C-SNSPD type devices, which make possible to maximize the polarization contrast by gradually decreasing the criterion regarding the absorptance that have to be met parallel. These results are presented in Appendix (Figure \[figA1\]-\[figA4\]).

Methods {#method}
=======

Four different types of plasmonic structure integrated SNSPDs were inspected theoretically, and for each design types three periodicity regions were considered, where special nanophotonical phenomena are at play (Figure \[fig1\]). Taking into account the $\lambda_{SPP}$ wavelength of the surface plasmon polaritons (SPPs) excitable at silica substrate and gold interface at


according to the increased periodicity (Figure \[fig2\](ac)) [@article31; @article33; @article53; @article54; @article55; @article56]. The largest absorptance is achieved close to the second Brillouin zone boundary. At 1550 nm 2.15% global minimum appears at 3.40$^{\circ}$ tilting, which is followed by a local maximum-minimum pair, manifesting itself in 24.51% and 19.63% NbN absorptance at 4.2$^{\circ}$ and 5.1$^{\circ}$ tilting. Then the NbN absorptance monotonously increases through the 72.82% global absorptance maximum appearing at 82.46$^{\circ}$ tilting corresponding to the PBA (Figure \[fig2\](a)) [@article31; @article33; @article42; @article43; @article44]. The attained absorptance is smaller than the absorptance observed in either of the NCAI$_{1/2*\lambda}$-A and NCAI$_{3/4*\lambda}$-A devices almost in the entire polar angle interval.

The optimization of half-wavelength-scaled NCDAI$_{1/2*\lambda}$-A-SNSPD resulted in 500.09 nm optimal periodicity and 108.72 nm optimal nano-cavity width (Figure \[fig1\](ba)). Their noticeable difference with respect tonm. This wavelength indicates that plasmonic modes are coupled at the inverted PBG center. By increasing tilting further the absorptance does not indicate enhancement at PBA corresponding to the array of NbN loaded nano-cavities.

The optimization of wavelength-scaled NCDDAI$_{\lambda}$-A-SNSPD resulted in maximal absorptance in 1042.83 nm pitch integrated pattern consisting of 109.15 nm wide nano-cavities (Figure \[fig1\](cc)). Although, the optimal 190.06 nm nano-cavity length is again larger than in NCDDAI$_{1/2*\lambda}$-A and NCDDAI$_{3/4*\lambda}$-A, it is smaller than the optimal nano-cavity length in counterpart NCDAI$_{\lambda}$-A. The deflectors at the anterior/exterior side of the cavities have larger/smaller length, compared to NCDDAI$_{1/2*\lambda}$-A and NCDDAI$_{3/4*\lambda}$-A (see Appendix Figure \[figA3\](cc)). The large 173.89 nm/97.32 nm lengths and 273.48 nm/295.77 nm widths at the anterior/exterior sides result in large competitive gold volume fraction. The dispersion characteristics indicates that


light in -1 order into backward propagating surface modes. As a result, larger absorption is achieved inside an inverted plasmonic band-gap at the top of the first Brillouin zone. The NCTAI$_{3/4*\lambda}$-A device’s absorptance characteristics is similar to the corresponding NCDDAI$_{3/4*\lambda}$-A, however all absorptance values are slightly larger and the extrema are shifted to smaller polar angles. The NCTAI$_{3/4*\lambda}$-A device shows 75.37% absorptance already at perpendicular incidence, than by increasing tilting the absorptance increases until 19.37$^{\circ}$ polar angle, where 94.95% global maximum is achieved. At this tilting light coupling occurs in -1 order into backward propagating surface modes having a wavelength of 1056.99 nm, which exhibit plasmonic characteristics. The absorptance decreases monotonously by increasing tilting, i.e. PBA corresponding to array of NbN loaded nano-cavities is not observable.

The optimization ofNCDAI$_{1/2*\lambda}$-A the polarization contrast is an order of a magnitude higher than in the counterpart NCAI$_{1/2*\lambda}$-A device. At perpendicular incidence the contrast is 552.68 and increases exponentially through 1552.96 at 85.00$^{\circ}$, without any significant modulation. In NCDAI$_{3/4*\lambda}$-A the contrast is $\sim300$ in the 0.00$^{\circ}$ - 20.00$^{\circ}$ polar angle interval, according to the plateau in polar angle dependent absorptances. At $\sim25.50^{\circ}$ orientation corresponding to the cut-off in p-polarized absorptance a global minimum arises, than the contrast increases and reaches 656.51 at 85.00$^{\circ}$. In NCDAI$_{\lambda}$-A the polarization contrast is 15.86 at perpendicular incidence and rapidly increases in a 2$^{\circ}$ interval according to the same characteristics of the p-polarized absorptance. By increasing tilting the contrast increases through the 2029.44 global maximum at 85.00$^{\circ}$.

In double-deflector integrated NCDDAI-SNSPDs the polarization contrast is further


absorptance, all in (a-c/a) NCDDAI$_{1/2*\lambda}$-C, (a-c/b) NCDDAI$_{3/4*\lambda}$-C, (a-c/c) NCDDAI$_{\lambda}$-C series.[]{data-label="figA3"}](fig7.pdf){width="0.8\columnwidth"}

In NCDDAI-C-SNSPD devices the polarization contrast rapidly and monotonously increases by decreasing the conditional absorptance, except in NCDDAI$_{\lambda}$-C, where the increase is non-monotonous (Figure \[figA3\](a)). The polarization contrast increases in $[1.38*10^3-2.24*10^9]/[2.00*10^4-2.83*10^8]/[1.39*10^4-1.35*10^{10}]$ intervals in NCDDAI$_{1/2*\lambda}$-C/NCDDAI$_{3/4*\lambda}$-C/NCDDAI$_{\lambda}$-C. The period non-monotonously varies in \[567.82 nm-558.56 nm\]/\[769.93 nm-784.41 nm\]/\[1042.83 nm-1058.73 nm\] regions. In NCDDAI$_{1/2*\lambda}$-C the tilting non-monotonously varies in \[60.89$^{\circ}$-59.57$^{\circ}$\] region, while in NCDDAI$_{3/4*\lambda}$-C slightly modifies in \[21.85$^{\circ}$-20.04$^{\circ}$\] region, i.e. the optimal polar angle is almost independent on the conditional absorptance. The optimal polar angle exhibits a jump in \[0.69$^{\circ}$-74.26$^{\circ}$\] interval in NCDDAI$_{\lambda}$-C, indicating that different nanophotonical phenomena become to play below certain level of conditional absorptance (Figure \[figA3\](a)/(a-c)).

The cavity lengths non-monotonously increase in $[0.62*(\lambda/4)-0.74*(\lambda/4)]/[0.71*(\lambda/4)-0.74*(\lambda/4)]/[0.74*(\lambda/4)-0.77*(\lambda/4)]$ intervals in NCDDAI$_{1/2*\lambda}$/NCDDAI$_{3/4*\lambda}$/NCDDAI$_{\lambda}$-C SNSPDs (Figure \[figA3\](b)/(a-c)). The cavity parameter tendencies result inenhancement for telecom-wavelength superconducting single photon detectors," [*Nano Letters*]{} Vol. 15/2, 819, 2014.

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[^1]: *Received date*

[^2]: -0.12in\* Corresponding author: Mária Csete (mcsete@physx.u-szeged.hu).

[^3]: -0.12in^1^ Department of Optics and Quantum Electronics, University of Szeged, Dóm tér 9, Szeged, H-6720, Hungary.\
    ^2^ Institute of Informatics, University of Szeged, Árpád tér 2, Szeged, H-6720,


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Note: the making of the pictopoiesis leoporellos is an act of meditation in itself – just the folding of the paper is enough to focus my mind on the act of making, poiesis, for the sake of it – a pictopoietic principle in practice.


the Western Wall in Jerusalem’s Old City. Women had previously been relegated to a small, cordoned-off praying area at the wall. The organization Women of the Wall has campaigned for equal prayer rights at the Western Wall for the past 27 years, holding monthly protests in the plaza in front of the wall’s ancient golden stones. Despite ultra-Orthodox cabinet members criticizing the move, The Israeli cabinet approved the plan without a formal vote. For more: The Guardian, NYTDrones deliver contraceptives, medical supplies to women in rural Ghana: Inspired by Amazon’s vision of unmanned delivery drones, public health specialists have created Project Last Mile, a scheme that uses drones to deliver contraceptives to women living in remote rural areas in Ghana. The initiative has been so successful in itshas completed 92 systematic reviews of interventions designed to improve the delivery, practice, and organisation of health care services, and protocols for a further 49 systematic reviews in this field \[[@B11]\]. Further, the Health Systems Evidence database contains over 4000 systematic reviews, evidence briefs and other syntheses of research evidence on governance, financial and delivery arrangements within health systems, and interventions designed to support change in health systems \[[@B12]\].

In a review of literature on evidence integration and translation in health care policy, Mitton et al. \[[@B13]\] identified a number of key strategies for achieving evidence integration, including i) face-to-face exchange between decision-makers and researchers (for example to gather information on current practices, develop relationships and broker involvement in change implementation); ii) the use of Networks and/or Communities of


informing and implementing organisational change, and facilitating the alignment of evidence-informed policy and practice. This is achieved principally through the engagement of multidisciplinary stakeholders to form working relationships in order to identify and develop solutions to system barriers. While the concept of a Network model is not new, its application to influencing organisational change in the health sector in an integrated and formal manner is an emerging field of interest for researchers and policymakers \[[@B18]\]. Evidence to substantiate the effectiveness of Networks in tackling clinical health issues is accumulating \[[@B20],[@B26]-[@B32]\], and a similar Network approach has been adopted in other fields, for example environmental science \[[@B33]\]. While discrete Networks such as clinical Networks, policy Networks, and service management Networks may evolve naturally, these Networks are potentially siloed due                               Invite individuals with interest and skill sets applicable to establishing a service (clinicians, consumers, policy makers, business managers, researchers). The importance of the end goal and how the proposed iterative processes aligned with individuals' interests were emphasised.
  Maintain government officer support.


               Maximising buy-in from other stakeholders (e.g. the clinical community, area health services, policy-makers) on a particular project can be facilitated by promoting a project objective and working group to these individuals. This may achieved through Network forums or e-newsletters. A broad support base help to forge and maintain partnerships and sustain the political will to support the initiative.                                                       active management by consumers for their pain conditions. The model is now recurrently funded and being rolled out into primary care settings.

•Providing interdisciplinary professional development in musculoskeletal pain to health care professionals in urban and rural WA, resulting in a sustained improvement in adoption of evidence-based practices for clinical management \[[@B57]\].

•Providing evidence-based self-management training and skills to consumers with musculoskeletal pain in rural WA, resulting in improved beliefs about low back pain and highlighting the need for sustained reinforcement strategies of positive self-management skills in rural WA \[[@B58]\].

•Undertaking an audit of beliefs and likely clinical practice behaviours in the context of low back pain among final year allied health and medical students in WA in an effort to assess local workforce readiness to deliver health services and information


Now, part of the Leicester City story has been good fortune. It has outperformed its expected goals for most of the season, scoring more goals and conceding fewer than would be typical based on chances created and conceded. Further, the Foxes have played extremely well in the clutch, consistently winning close matches at rates that are probably not sustainable. In matches decided by one goal or fewer, Leicester is 14-10-2, by far the best in the Premier League. As is clear from the chart, while the best teams tend to win the most close matches, it is not as strong a marker of team quality as points. Indeed, clubs that win lots of close matches tend to regress to the mean.

Of course, Leicester has resolutely failed to regressof section 530 are satisfied.   Subsection (a)

of that section provides in relevant part as follows:

     (a) Termination of certain employment tax liability
     * * *.--
          (1) In general.–-If–-
                 (A) for purposes of employment taxes,
          the taxpayer did not treat an individual as
          an employee for any period * * *, and
                 (B) in the case of periods after


the individual
     shall be deemed not to be an employee unless the
     taxpayer had no reasonable basis for not treating such
     individual as an employee.
                                 - 19 -

                     *   *   *     *      *   *   *

          (3) Consistency requiredpeople were injured on the Westminster Bridge. Another witness told Sky News that there was an “almighty crash” as a vehicle hit the railings outside Parliament. A witness told Sky News: “Someone rushed through, attacked a policeman… he appeared to be carrying a knife. We heard lots of gunfire.” Witness Jayne Wilkinson told the Telegraph: “We were taking photos of Big Ben and we saw all the people running towards us, and then there was an Asian guy in about his 40s carrying a knife about seven or eight inches long.”

Sigh.

I’m so fucking bored of this shit.

What are we supposed to say about this?

Are we supposed to cry and pretend we care?

Are we seriously supposed to act like we’re shocked?

There is always a terrorist attack coming. After each


There is known an optical component. Such an optical component is attached on a printed substrate. The optical component is attached on the printed substrate by a dedicate attachment part. The related arts are disclosed in Japanese Laid-open Patent Publication Nos. 10-98203 and 7-15032.
There is an attachment part which fastens the optical component with a band. However, the fastening with the band has to be conducted by hand, and may degrade the attachment workability.“I cannot live without that”, or “I’ll allow myself the luxury of this” – or our old excuse, when we tell ourselves, “I deserve this!”

To be aware of one’s every thought, word and action is undoubtedly a huge challenge but I accepted it. He had been right: it took me years of work. For me, the process was gradual. When I finally realized that my actions were no longer based on self-pity, I felt I had truly cast off a heavy burden. The most incredible thing however was that previously I did not even notice it was there.

This task is really a twenty-four hour a day battle the warrior fights against himself, against his self-importance and self-pity, and is ultimately the battle against his own stupidity. To win


it, one must force oneself at all times not to relax one’s vigil and to sustain round-the-clock awareness, since, if one lowers one’s guard for a single moment, one looses protection against the onslaughts of the ego.

Now I understood what Carlos meant when he said that one had no need of teachers. He maintained that fighting self-importance was like going to the toilet, something one had to do on one’s own, since it was strictly personal business. The struggle was against one’s own ego and no one could help us with that.

The only external help our peers can, perhaps, provide is to make us aware of our weaknesses. That, however, gives rise to a new problem: we often see those who warn us of our faults as adversariesUCLA – A rim protector and rebounder who changes the game on the defensive end. Very raw but promising player who might take a few years but should be worth the wait. He’s got great length and tons of untapped potential. longer Tristan Thompson

18 Pacers Harry Giles PF – 6-10 – Duke – At this point in the draft it’s OK to swing for the fences. Giles is a multi-talented power forward with advanced ball skills but slowed by injuries. Even if he doesn’t regain his explosiveness he has enough length and skill to be an effective player. Rasheed Wallace/Bobby Portis

19 Hawks Justin Patton C – 7-0 – Creighton – A big, athletic center with impressive skills and nice mobility, Patton would give the Hawks a young front


only.

It’s my first post of 2018, and we are starting off with the latest DC Legion of Collectors box by Funko. This month’s theme is the Teen Titans, based off of the “New” Teen Titans comics that ran from 1980 to 1996. Will this box rate a “Boo Yah!” from Cyborg? Let’s take a look!

For those unfamiliar with the Teen Titan’s history, here is a little back story. Originally conceived as a team made up of the sidekicks of various Justice League members, the Teen Titans featured Robin, Kid Flash, Speedy (Green Arrow’s sidekick), Aqualad and Wonder Girl. The group had two series in the 60’s and 70’s (plus a cartoon that omitted Robin) and was mildly successful. But in the 70’s, the trend was to age upNew Teen Titans series.

There is no flap any more and we only get a patch this time. Cyborg is featured on the patch in his 80’s design. It is good that this character has evolved over the years and now is part of the Justice League franchise.

We get a comic this time, too. It is a copy of The New Teen Titans #1 from 1980. IT features a new cover by artist Phil Jimenez, the original story from 1980 and a couple of Who’s Who in the DC Universe pages from 1986 featuring the team and the Titans Tower. The cover is really nice and the story, well old, still holds up.

Next we get…figures! I really like the Funko figures we have been getting and I have said


Viability of micrococci and lactobacilli upon freezing and freeze-drying in the presence of different cryoprotectants.
Studies were conducted on the viability of Micrococcus varians strain M95 and Lactobacillus plantarum strain L4 upon freezing and freeze-drying using five cryoprotectants (sucrose, lactose, sodium glutamate, peptone, dry nonfat milk) singly or in combinations with gelatin, glutamic acid, and sodium acetate. The number of survivals was determined immediately after treatment and after storage at room temperature or refrigeration temperatures, under vacuum or in air. Dry nonfat milk and peptone introduced at the levels of 8 and 5%, respectively, to broth culture, were found to be the best cryoprotectants providing a 100% viability determined immediately after the treatment of the strains under investigation. Immediately after freezing and freeze-drying, the numbers of viable micrococci remainFuture Past” is scheduled to hit theaters on July 18, 2014.

Marvel Studios and Arad Productions are gearing up to start shooting the sequel to “The Amazing Spider Man” this February, 2013 in New York. The casting director for “The Amazing Spider-Man: London Calling” is auditioning actors for starring and co-starring roles. Stand-ins for the film’s actors will be hired closer to the start of filming, as well as extras being cast throughout the shoot in New York and Los Angeles. “The Amazing Spider-Man 2” is scheduled for release on May 2, 2014.

Chris Evans reprises his role as Steve Rogers in “Captain America: The Winter Soldier”.
Creative Commons

Marvel Studios is set to begin shooting the superhero feature film sequel “Captain America: The Winter Soldier” on March 1, 2013. The locations


curves aren't. However, the imbalance doesn't seem to affect the individual features: I can get pretty high precision using the individual features (blue and cyan).

I don't understand what's going on. I could understand it if everything performed badly in PR space, since, after all, the data is very imbalanced. I could also understand it if the classifiers looked bad in ROC and PR space - maybe they're just bad classifiers. But what is going on to make the classifiers better as judged by ROC, but worse as judged by Precision-Recall?
Edit: I noticed that in the low TPR/Recall areas (TPR between 0 and 0.35), the individual features consistently outperform the classifiers in both ROC and PR curves. Maybe my confusion is because the ROC curve "emphasizes" the high TPRareas (where the classifiers do well) and the PR curve emphasizes the low TPR (where the classifiers are worse).
Edit 2: Training on nonbalanced data, i.e. with the same imbalance as the raw data, brought the PR curve back to life (see below). I'd guess my problem was improperly training the classifiers, but I don't totally understand what happened.

A:

I've found that there isn't an incredible benefit in using downsampling/upsampling when classes are moderately imbalanced (i.e., no worse than 100:1) in conjunction with a threshold invariant metric (like AUC). Sampling makes the biggest impact for metrics like F1-score and Accuracy, because the sampling artificially moves the threshold to be closer to what might be considered as the "optimal" location on an ROC curve. You can see an example of this


prevent the default action from a form submission, I did this:
close.addEventListener('click', function(e) {
  e.preventDefault();
  value = checkbox[0].checked;
  updateCard(value);
});

Westmeath and moved with his family to Ballymun, Dublin in the 1950s. Daltun’s first employment, for about two years, was in Gael Linn, an organisation founded to foster the Irish language. He spoke Irish with a perfection rarely found outside of the Gaaeltacht. Daltun was a particularly gifted linguist and also spoke French, Spanish, Italian and Russian.

His association with radicalism went back to his youth when, at 18 years of age in 1954 he joined the IRA. He later left the IRA and operated with the breakaway Joe Christle group during the 1950s Republican Border campaign. The Christle Group, along with Daltun, blew up nine customs posts along the border with the north of Ireland in 1956. Around this time he was arrested in Dublin; his trial was


Order "Human Rights» (Le Droit Humain), engaged in the protection of civil rights. In 1929 she became head of the Russian-speaking Lodge "Aurora", a constituent institution of this Order, and remained a member of the Lodge until 1939. She equated Theosophy to Freemasonry. After the beginning of the German occupation of France and closing all Masonic Lodges on its territory her fate is unknown.

Family
Husband - Ali Oscar (Galiaskar) Shahaydarovich Syrtlanov (1875–1912), also referred as Aliasgar Sirtlanov in the English translation of the book of Zeki Velidi Togan, member of the 3d State Duma of Russian Empire, a lawyer at the trial of  Vice Admiral Rozhestvensky, Admiral Nebogatov and Lieutenant General Stessel, accused in the defeat of the Army and Navy in the Russian-Japanese War of 1904–1905.

Interesting Facts
InCompany name

What inspires you and how do you envision the design for your business?

- Design must include a header that displays Bridgette & Jonathans Wedding Website. As this will eventually be dynamic.
- Must include a left navigation with the same sub pages.
- The Music Player must stay exactly the same
- All the content will remain the same, the text styles can change.
- The photos will remain the same, however you can create a different border style to match your design
- The footer content must remain the same, however have it match your design.
- Keep in mind that we intend on using you design, and allowing brides to select different color variations of your design.

Wants

- We are looking for about 14 different designs, and will award all 5 Star


Q:

Android - change dialog title style of all dialogs in application

Is there a way I can change all the alert dialogs appearing in my Android application? I want to change the dialogs that are system generated as well (like the Edit Text dialog that opens up when you long tap on any EditText). I want to change the title font color and size of all the dialogs in my app.
Is there a way to do it?
I have tried setting android:alertDialogTheme in my theme. But it seems to be not working.  Code following -
<style name="Theme.DLight" parent="android:Theme.Light.NoTitleBar">
    <item name="android:alertDialogTheme">@style/DialogStyle</item>
</style>

and
<style name="DialogStyle" parent="android:Theme" >
    <item name="android:windowBackground">@drawable/background_holo_light</item>
    <item name="android:textColor">#014076</item>
</style>

EDIT

I'm notsurgeries. Axillary dissection was carried out when sentinel lymph node was positive.

Pathological results were evaluated by more than 2 associate chief physicians, according to the WHO classification. The IHC standard referred to St. Gallen version 2013: estrogen receptor (ER) positive defined ≥1%; progesterone receptor (PR) positive meant ≥20%; and HER-2 over-expression considered complete and intense membrane staining of at least 10% of neoplastic cells (3+). Tumors showing weak-to-moderate circumferential membrane immunoreactivity (2+) of HER-2 were further subjected to fluorescence in situ hybridization assays.

Endocrine therapy for more than 5 years was recommended to ER-positive patients. Patients with HER-2 over-expression were prescribed to receive Herceptin, a target therapy, after chemotherapy. (Among 238 ER-positive patients, 11 obtained the IHC rates above 1% and less than 10%. They were reassessed before taking


models were used to identify the variables associated with OS, DFS, and BMFS. These variables are presented in Table [2](#T2){ref-type="table"}.

######

Cox Proportional Hazards Regression Models of Risk Factors Associated With OS, DFS, and BMFS Among Breast Cancer Patients (n = 410)

![](medi-95-e3240-g005)

In univariate analysis, age, premenopausal status, HER-2-positive status, conservative surgery, and chemotherapy regimens, as well as counts of leukocytes, neutrophils, lymphocytes, and platelets were not significant predictive factors for the prognosis of OS, DFS, or BMFS in the patients with invasive BC. Pathological T staging was significantly related to OS and DFS. The ER- or PR-positive status was a significant predictive factor only for OS and not for DFS or BMFS. The presence of CIN and age under 40 were only inversely associated with DFS and BMFS. PVI and thethe cost-effectiveness of an intervention.

Quality-of-life measures such as the EQ-5D^[@ref8]^ and the SF36^[@ref9]^ can be applied to the whole population but, because of their origins in research in physical medicine, are often too oriented to physical aspects of life experience. Others such as CORE-OM^[@ref10]^ are essentially measures of symptom state. The advantage of quality-of-life measures is that if they are preference-based they allow derivation of quality-adjusted life-years and thereby allow estimation of the comparative cost-effectiveness of an intervention. It is uncertain how they relate to other outcomes or predict repetition or suicide.

Functional measures have a different aim, which is to pick up on people\'s ability to live a life that they find satisfactory -- by being able to do everything they want physically, by being able to socialise


multiple outcomes raise formidable analytic problems^[@ref13]^ even if researchers can overcome the practical challenge of low completion rates as a result of respondent burden. Composite measures have been used, but only when the elements are meaningfully related to each other -- suicidal thinking, non-fatal self-harm and suicide for example -- but even then they are problematic. There is no plausible composite outcome that could be derived from the diverse outcomes outlined above.

Is personalisation possible? That is, could outcome for each participant be individual to that person, with grouping of results achieved by standardising the response format? One example is Goal Attainment Scaling.^[@ref14]^ Although appealing in principle, concerns about reliability of scores and of their comparability across individuals and groups of individuals has limited the take up of suchdecreased protein yield but may not have much influence on immunoreactivity and electrophoretic mobility. Interestingly, not all staining protocols tested are compatible with subsequent protein analysis. The commonly used hematoxylin staining was found to be suitable for multiplexed quantitative protein measurement technologies although protein extraction was less efficient. For best results we suggest a guided protein extraction method, in which an adjacent hematoxylin/eosin-stained tissue section is used to control dissection of an unstained specimen for subsequent protein extraction and quantification for research and diagnosis.


view of the ceiling: the dog constellation
 An image of Kent working on the murals, Popular Science Monthly, September 1930

Category:Cinemas and movie theaters in Massachusetts
Category:Music venues in Massachusetts
Category:1930 establishments in Massachusetts
Category:1930 in Massachusettsinterest.”

Over the weekend, the Maryland House of Delegates passed the unprecedented bill. Most states are mitigating damage done by the GOP tax bill by passing state-level mandates, as was the case in New Jersey and Vermont.

“Right now we are focused on making this bill work to see how many people we can get insured through extensive use of the tax system… other states should do the same thing,” said Maryland Health Care for All Coalition President Vincent DeMarco. DeMarco is also a part of a Maryland state panel tasked with monitoring and responding to Republican attempts to chip away at the ACA.

“The most important thing we can do is protect and build on the Affordable Care Act,” DeMarco told ThinkProgress, adding that he’d like to see a 2020


fund’s volatility was still elevated, mostly likely due to its concentrated holdings.

The following chart with related statistics depicts the fixed reference ETF portfolio over the same three-year period:

In the fact sheet, Evermore Global Value emphasizes its unique strategy: difficult to replicate, special-situations focused investments, typically concentrated in 30-40 positions with an active share near 100. However, in itself an unconventional approach is not a guarantee of success – it was only over the past year that this strategy added any significant value after adjustment for volatility and exposures. As usual, investors are advised to analyze a fund’s performance year by year, instead of just looking at the annualized returns over the industry’s standard one-, three- and five-year periods.

To learn more about the Evermore Global Value and other mutualthan the S&P 500, and ahead of 74% of its competitors.

With an inception date at the end of 2010, the fund has a relatively short history. Therefore, the following analysis will focus on the three- and five-year periods through August 2016.

The prospectus benchmark for the fund is the S&P 500 Index. One of the efficient implementations of this index is the Vanguard S&P 500 ETF (VOO). Alpholio™ calculations indicate that the fund returned more than the ETF in only 8% of all rolling 36-month periods, 22% of 24-month periods and 35% of 12-month periods. The median underperformance over a rolling 36-month periods was 4.9%.

A comparison of rolling returns, which determines relative gains or losses of the fund over typical holding periods, does not adjust for the fund’s volatility


the long-lived and low-cost implementations of this index is the SPDR® S&P 500® ETF (SPY). Alpholio™’’s calculations indicate that over the 10 years through June 2016 the fund returned more than the ETF in only 15% of all rolling 36-month periods, 35% of 24-month periods and 42% of 12-month periods. The median cumulative (not annualized) under-performance over a rolling 36-month period was 5.5%.

The secondary prospectus benchmark for the fund is the Russell 1000® Value Index. The iShares Russell 1000 Value ETF (IWD) is one of the accessible implementations of this index. Over the past 10 years through June 2016, the fund outperformed this ETF in about 40% of all rolling 36-month periods (median cumulative return difference of negative 1.4%), 53% of 24-month periods and 47% of 12-month periods.

Awhich way to go only because I was following my fellow journalists on the trek. Next time, I’ll ask to ride on the back of a snowmobile driven by a guide. Or maybe there won’t be a next time. I’ve crossed it off of the bucket list and I’m not sure I need to do it again.

Visiting Sleeping Bear Dunes

Our snowshoeing adventure took place at the breathtaking Sleeping Bear Dunes National Lakeshore. I’ve seen the dunes in the summer, when the white sand mountain shimmers in the sun. But it’s equally beautiful dressed in snow.

My last snowshoe adventure, across Lake Michigan in Door County, Wisconsin, I used new-fangled aluminum snowshoes). But this time I strapped the old-fashioned kind to my feet—the snowshoes that have always reminded me of


which is implicated in imprint protection ([@DEV167833C35]) ([Fig. S2B](Fig. S2B)).

At the zygote stage, 856 transcripts were present (FPKM\>10) in human and marmoset, but not in mouse ([Fig. 2](#DEV167833F2){ref-type="fig"}E, [Fig. S2C](Fig. S2C)). Pathway and Gene Ontology (GO) analyses identified genes associated with 'ribosome', 'cytoplasmic ribosomal proteins' and 'translational termination', indicating an abundance of transcripts involved in translational processing ([Fig. S2D](Fig. S2D)). Consistent results were obtained with individual GO term analyses confined to each species ([Fig. S2E-G](Fig. S2E-G)). We compared enrichment scores of the most significant processes identified in humans with those in marmoset and mouse ([Fig. 2](#DEV167833F2){ref-type="fig"}F). General biological processes, such as 'gene expression' and 'mitotic cell cycle' were elevated in all species. However, terms associated with translation were highly enriched in primates and lacking in mouse. We also assessed individual ribosomal transcript RNA levels and found substantial reductionsthe end of the time series in late ICM cells, the numbers of stage-specific genes were similar in all species ([Fig. 3](#DEV167833F3){ref-type="fig"}F). This set of expression modules allowed us to define common and primate-specific processes at each developmental time point. Surprisingly, at the eight-cell stage, compacted morula and early ICM stages, we found little correspondence between rodents and primates ([Fig. S3E-G](Fig. S3E-G)). In human and marmoset, the eight-cell transcriptome exhibited clear signs of ZGA, whereas the early ICM featured lipid metabolism. However, in the late blastocyst, we identified several biological processes conserved in all species, including ERK signalling and upregulation of extracellular matrix components ([Fig. 3](#DEV167833F3){ref-type="fig"}G). We additionally identified a substantial fraction of primate-specific processes, primarily relating to WNT signalling, cell adhesion and apoptosis. This analysis faithfully captures known features of EPI


all trophectoderm cells ([Fig. 7](#DEV167833F7){ref-type="fig"}E). OTX2 colocalised with intermediate levels of GATA2 inside the blastocyst, corroborating PrE-specific expression.

Rodent Otx2 directly binds regulatory genomic sequences of *Nanog* ([@DEV167833C2]). We therefore investigated the relationship of *NANOG* and *OTX2* transcriptional activity in each species at the single cell level. *Nanog* and *Otx2* were co-expressed in all cells of the mouse EPI ([Fig. S7A](Fig. S7A)), whereas in human and marmoset *OTX2* was absent in half of EPI cells (marmoset 20/32, human 20/54) and expressed at low levels in the remainder ([Fig. S7B,C](Fig. S7B,C)). Mouse *Otx2* was consistently absent in PrE cells (41/44) ([Fig. S7D](Fig. S7D)). In contrast, *OTX2* was expressed in the majority of primate PrE cells (marmoset 34/47, human 32/38) ([Fig. S7E,F](Fig. S7E,F)). In the human embryo, cells with the highest levels of *OTX2* were devoid of *NANOG*.

This led ustranscription factors (*ETV4*/*5*), which are involved in cell proliferation and induction of differentiation-associated genes in mouse embryonic stem cells ([@DEV167833C3]). Interestingly, we also found *RBPJ*, a transcriptional repressor regulated by Notch signalling, to be an integral part of the EPI program in all three species, despite the absence of Delta/Notch receptors. Mouse *Rbpj* is not required for self-renewal in embryonic stem cell lines, but is implicated in early differentiation and neural lineage entry ([@DEV167833C56]; [@DEV167833C53]).

Repetitive DNA sequences have been introduced into mammalian genomes over evolutionary time, and constitute approximately half of the human genome. Transposable elements are subject to epigenetic control and expression during early embryogenesis, and associated transcription may provide a signature to define developmental states. Correspondence in transposcriptome has been proposed as a metric for comparison


Carl Fabian Björling

Carl Fabian Emanuel Björling (30 November 1839 – 6 May 1910) was a Swedish mathematician and meteorologist.

Life
He was born on 30 November 1839 in Västerås, Sweden, and died on 6 May 1910. He was the son of mathematician Emanuel Björling and father of lawyer Carl Georg Björling.

Career
He attained his Ph.D. from Uppsala University in 1863. In 1863, he became an associate professor of mathematics at Uppsala University. In 1867 he was appointed a lecturer of mathematics and physics at the Halmstad grammar school.

From 1873 to 1904 he was the professor of mathematics at Lund University. In 1886, he became a member of the Royal Swedish Academy of Sciences.

References

External links

 Author profile in the database zbMATH

Category:1839 births
Category:1910 deaths
Category:Swedish mathematicians
Category:Swedish meteorologists
Category:People from Västerås
Category:Uppsala UniversityQ:

NodeJS Promise and Symbol.species usage

I trying to subclass the standard promise object, but I want then to return a standard promise object not my subclass.
class CustomPromise extends Promise
{
    constructor(fn)
    {
        super(fn);
    }

    static get [Symbol.species]()
    {
        console.log("get Symbol.species");
        return Promise;
    }

    toString()
    {
        return "CustomPromise";
    }
}

var p = new CustomPromise((resolve) => resolve(5)).then(v => console.log(v) );
console.log(p.toString());

That works fine with chrome were I see:
test4.js:12 get Symbol.species
test4.js:25 [object Promise]

But doesn't seems to work with NodeJS
node ~/Documents/test4.js


Agoraphobia Scale showed significant improvements. The highest treatment effect sizes were seen in the "panic attacks" subscore, followed by the "anticipatory anxiety" subscore. The new statistical test applied in this study, which has some advantages in comparison with previously applied tests, is suitable for psychiatric treatment evaluations since it can also be applied in the case of discrete repeated measurements.0.01 (uncorrected, \>50 voxels).\[^11^C\]PBB3 = 2-(\[1*E*,3*E*\]-4-\[6-(\[^11^C\]methylamino)pyridin-3-yl\]buta-1,3-dienyl)benzo\[*d*\]thiazol-6-ol.](NEUROLOGY2018904797FF3){#F3}

![Regional binding potential (*BP*\*~ND~) of \[^11^C\]PBB3 in 13 old healthy controls (HCs) and 6 Kii amyotrophic lateral sclerosis (ALS)/parkinsonism dementia complex (PDC) patients\
\**p* \< 0.05, \*\**p* \< 0.005 by Holm-Sidak multiple comparisons test. Regions highlighted in bold type indicate those with differences in *BP\**~ND~ between old HCs and Kii ALS/PDC patients.\[^11^C\]PBB3 = 2-(\[1*E*,3*E*\]-4-\[6-(\[^11^C\]methylamino)pyridin-3-yl\]buta-1,3-dienyl)benzo\[*d*\]thiazol-6-ol; GM = gray matter; WM = white matter.](NEUROLOGY2018904797FF4){#F4}

In a group-wise volume of interest (VOI) analysis of \[^11^C\]PBB3 PET data, *BP\**~ND~ for this radioligand was higher in the hippocampus and in frontal and parietal white matter of Kii ALS/PDC patients than in old HCs ([figure 4](#F4){ref-type="fig"}). In Kii ALS/PDC patients, MMSE scores were positively correlated with *BP\**~ND~ in frontal (*r*~s~ = −0.886, *p* \< 0.05), temporal (*r*~s~ = −0.943, *p* \<