77 compiler FTN77. In August 2004 Salford Software relinquished control of FTN95 to Silverfrost Limited. Silverfrost FTN95 is often referred to as Salford FTN95 because of its University of Salford pedigree.

References

External links

Category:Fortran compilers
Category:Programming tools for Windowsand tissue remodelling-related cytokines (PDGF and VEGF) \[[@CR18]••\]. This pattern of cytokine release might contribute to the prolonged airway inflammation and airway structural changes typical of asthma. Foetal lung fibroblasts infected with hPIV release an array of cytokines, including the proinflammatory cytokines IL-1β, IL-6 and TNF-α, the anti-inflammatory cytokine IL-1ra, Th1 cytokines (IFN-γ and IL-2), Th2 cytokines (IL-4, IL-5 and IL-10), granulopoiesis-inducing cytokines (granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor), neutrophil recruitment-inducing cytokines (IL-8 and interferon-inducible protein-10) and eosinophil recruitment-inducing cytokines (eotaxin and RANTES) \[[@CR19]••\]. A recent study reported that hPIV-3 infection of human airway epithelial cells (RPMI 2650) might induce the expression and release of interferon gamma, potentially contributing to local antiviral defence. Additionally, although the RANTES protein concentration and mRNA expression were significantly increased after infection,


more than twice as prevalent among older adults (55--73 years old) as among younger individuals (18--34 years old) \[[@CR20]\]. In Norway, 1:8 parainfluenza virus antibody titres were more prevalent for type 2 than types 1 and 3 and were detected in over 10 accumulated percentages of the adult general population \[[@CR20]\]. Moreover, the immunologic response to hPIV infection is mediated primarily through antibodies belonging to the IgG1 subclass; however, 30% of the infected adults additionally demonstrate increased serum levels of IgG3, IgG4, IgM and IgA. hPIV-3 infects approximately two-thirds of the children during the first year of life, causing symptomatic disease in approximately one-third of them. By the age of 3 years, most children will demonstrate serological evidence of infection. Immunity to hPIV-1 and hPIV-2 develops later than immunity to hPIV-3,host CD46 (which mediates C3b cleavage) and CD55 (which inhibits C3 complex formation) into the virion envelope during budding, thereby delaying complement-mediated neutralization \[[@CR14]\].

Clinical features of hPIV-induced respiratory tract infections {#Sec5}
==============================================================

Whereas the nasopharynx and oropharynx are primary locations of initial hPIV replication, hPIVs have also been associated with upper and lower respiratory tract illnesses, including the common cold, laryngotracheobronchitis (i.e. croup), tracheobronchitis, bronchiolitis and pneumonia, in both children and adults \[[@CR1]\]. Although these infections are rather mild in healthy individuals, they may lead to serious respiratory diseases in children and immunocompromised individuals.

Following experimental infection in adults, the first symptoms manifested 3 to 4 days post-inoculation and lasted up to 17 days, with an average of 4 days for hPIV-1 and 6 to 13 days for hPIV-2 and hPIV-4 \[[@CR27]\], respectively. Despite being


small group of adult asthmatics with asthma exacerbation, 60% of the cases were infected with hPIV-3, and among those individuals infected during mild cold-induced asthma exacerbation, a significant release of cysteinyl leukotrienes into the induced sputum was observed \[[@CR39]\]. Frost et al. \[[@CR10]\] in a large-scale retrospective analysis of 11,533 specimens collected from children with respiratory symptoms revealed that 752 samples (6.5%) were positive for hPIV1--4. Of the 316 samples that were positive for only hPIV, 41 (13%) were collected from children with asthma; however, no significant differences were observed in the prevalence of the four HPIV serotypes in these subjects. In another study of 309 nasopharyngeal samples collected from children with lower respiratory tract infections, 19 (6.1%) samples were positive for parainfluenza virus. A more detailed analysisand 6 months of age \[[@CR41]\]. This trial demonstrated that bPIV-3 was safe and well tolerated in infants; moreover, the immunization elicited a humoral antibody response to bPIV-3, which cross-reacted with hPIV-3. Because the bPIV-3 vaccine used in this phase 2 trial was prepared using foetal rhesus monkey lung-2 (FRhL-2) cells, other attempts were necessary to identify suitable cell substrates for the commercial production of bPIV-3 given that the routine vaccine manufacture using FRhL-2 cells is not feasible. Promising results were obtained for antigenically and genetically stable attenuated strains of hPIV-3, derived using a classic attenuation approach of successive passage at lower temperatures (cold adaptation) and which appeared to be even more immunogenic than bPIV-3 \[[@CR54], [@CR58], [@CR59]\].

More recently, the cDNA-derived recombinant vaccine rHPIV3cp45 was developed, containing 15 known


     This memorandum opinion was not selected for publication in the New Mexico Appellate Reports.
     Please see Rule 12-405 NMRA for restrictions on the citation of unpublished memorandum
     opinions.   Please also note that this electronic memorandum opinion may contain
     computer-generated errors or other deviations from the official paper version filed by the Court of
     Appeals and does not include the filing date.

 1        IN THE COURT OF APPEALS OF THE STATE OF NEW MEXICO

 2 CHARLES D. HOBSON,

 3      Petitioner-Appellant,

 4 v.            Previous proposals for garments that would protect a wearer by sorbing toxic vapors or gases have a number of deficiencies. A major deficiency is the failure to provide desired levels of vapor sorption and still maintain sufficient transfer of heat and moisture to keep a wearer cool and comfortable. For example, one previous garment lined with a carbon-loaded open-celled polymeric foam (see U.S. Pat. No. 4,046,939), allows a wearer to perform only limited activity before heat and moisture levels within the garment become intolerable.
Other deficiencies of previous vapor-sorptive garments are that binder materials used to adhere activated carbon particles in place in some garments cover part of the activated carbon particles and limit their useful life; carbonized fibers used for vapor-sorption in some garments are prohibitively expensive; and


1) Studies with Ca. We have measured total Ca content in intact red cells using both Ca45 and total Ca in dry ashed red cells and find that in each case equilibrium is achieved within two minutes and the results are identical with both isotope and total Ca. Measurement of binding constants of Ca to the external membrane surface by Scatchard analysis has been carried out under physiological conditions and our results have been compared with binding constants obtained under quite different conditions by other workers. We have begun experiments to measure Ca binding to the inside of the membrane using inside-out vesicles prepared by the technique of Steck et al. Preliminary measurements have been made of binding constants of the Ca-membrane complex to allow comparison with theThis is what happens when a neophyte General Manager and a neophyte Head Coach strip the team of veteran talent to "retool", leaving a leadership void throughout the organization.

It goes beyond that, though.

We understand where this has come from—the top. The Glazers. Up to their eyeballs in debt and seeing a lack of fan interest, the Glazers decided that now is the time to scale back a bit. Reinvent the interest in the team.

With the lockout looming in 2011 and a potential uncapped free agency session this year, the Glazers can milk this cash cow till its dry, breaking it down to it's most simplest form.

You can see the plan, can't you? Make do with Morris for a couple seasons. Spend wisely (i.e. frugally) on free agency, retain


dogs defense. You don't play violent, you play tentative.

Once the Bucs hit the bye week and their losing streak stretched to eleven, the time came to turn the ball over to Freeman.

But Freeman can't establish a running game. Freeman can't tackle or stop the run. He can't catch the football. He can't call plays or mold a defense that matches the personnel.

He's just a neophyte (there's that word again) QB who needs time to develop. A receiver or two wouldn't hurt, either.

Ten games into the season, Raheem Morris has finally figured out what we all already knew about the defense.

Jim Bates' defense was obsolete three years ago. He was bounced out of Green Bay, failed in Denver, and has turned a once proud defense into a laughing stock.

ThereBioJava:CookBook:OBO:parse

How to parse an Ontology (OBO) file

BioJava now contains a parser for .OBO
files. The BioJava
parser is re-using parts of the parser contained in the OBO-Edit
software package,but
does not require to have the obo-edit library and user interface
installed in order to parse the files. Thanks to the OBO-Edit developers
for giving permission to re-use part of their source code.

This code will be released with the next biojava release. To use it at
the moment you will require a recent build from
SVN.


isn’t factually incorrect to say that these series are pandering…but I think it doesn’t really serve a purpose to say it. It’s lazy shorthand for “I’m not willing to evaluate this honestly because *I* think it is beneath me”. Even if the critic was to say something like “sexual stuff in a cartoon makes me uncomfortable, so I didn’t like it”, at least that would be honest. You could question why they are reviewing it, but at least it would be honest. Hiding behind the “pandering” argument is basically them hiding the true reason why they dislike it, probably because saying what they mean would sound dumb.

Ultimately, what my dad and I determined was that the people that produced this material clearly wanted to do it that way,games, if there’s no bread, make the games more intense... yeah, that’ll work...

Or maybe – I dare not to think that could be true – some people still think they can serbify Croatia. Nah, that couldn’t be... no one is that stupid. I mean, stubborn.

All glory to all of my good neighbours, may they keep their heritage whole and alive, may we all notice the importance of patience and may we finally move into the future together.

Or as Nikola Tesla, great inventor and visionary, who happened to be a Croatian Serb, would say:

“I’m proud of my Serbian heritage and my Croatian homeland.”

But how would ghouls start new wars if people paid attention to what Tesla said? They need Britneys to protect minorities by stirring up the pot.

Get the


the issue in Vukovar. People who survived Serbian camps are – naturally, if you are willing to think about it – not happy with possibility of symbolic return of the occupation.

They won’t mind Cyrillic, but they do mind pushing it into their faces.

Why it was so important to insist on overuse of Cyrillic, right in Vukovar and right now... who knows. Maybe bad economic situation makes Serbian politicians in Croatia, whose only platform is being Serbs, lose their voters so they had to reheat the old political stew again in order to keep themselves popular. Bread and games, if there’s no bread, make the games more intense... yeah, that’ll work...

Or maybe – I dare not to think that could be true – some people still think they canthe some places of the Vojvodina region, where for example a lot of Hungarians live, the latinic is in wide use (there cyrillic serbian, latinic serbian and hungarian stand together on traffic signs.)

Keep in mind Hungarians make up only 20% in that city above yet they rights are respected in Vojvodina. In Vukovar where Serbs make up more than 1/3 of the population yet some want to deny minority rights there.

Vojvodina officially has six official languages used in different capacities.

Nevertheless, under the Socialist government, minority rights were enshrined by law and the various minority languages spoken in Vojvodina were protected and recognized to a certain degree. The ones with the most numerous speakers – Hungarian, Ruthenian/Ukrainian, Slovak and Romanian – are used on official buildings and signs, while


community tried to restore peace to the Balklands by creating Yugoslavia. The Croatians rebelled in 1991 starting yet another conflict in the region. Serbia, angry at the genocide and rebellion, then got its revenge by killing Croatians.

It seems to me Croatians moan a lot at Miloevic but in truth he was a great leader. He didnt take any nonsense of them and sent his forces in to kick butt. It always seems to be Croatia starting wars and killing other people. We find them at it again now with trying to surpress minority rights.

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Avatar Samantha Ai 1,502

My understanding of the situation is that during WW2 Croatians put on Nazi uniforms and went and genocided Serbs. Then the international community tried to= 0.0019). While the fractures in the UTR occurred exclusively above the cementoenamel junction (Mode 1 and Mode 2) and were rated reparable, RCT-COM and RCT-CER showed exclusively catastrophic failures in varying modes (nodes 3 to 5). Only in group RCT-FRC, half of the specimens fractured in a reparable fracture mode (modes 1 and 2) with veneering composite delamination from the glass-fiber weaver layer. As cusp-covering overlay restorations in root canal treated molars, composite resin overlays with and without fiber reinforcement performed similar to intact teeth with varying failure types. While intact teeth failed exclusively in reparable modes, all other restorations failed in a catastrophic manner, except half of the fiber reinforced composite group.


e-mail me (sml.woodturner@att.net) or Bob Fahrnbruch (rslf2@verizon.net) your answer. Or bring it to the February meeting where I will take your suggestions. This will aid us in preparing content for the half-day demos.

Steve

New and continuing members should pay their 2009 club dues of $25 to treasurer Ron Lindsay. Please mail them to him or bring to the meeting. The membership forms in Word and Acrobat formats can be accessed from the top of the Bylaws page.

New Members:

Kathiee Huelskamp, Richard Ingram,

Dana and son Johnathan Christensen,

Kathy and Gayron Downs,

Larry Harms and son, and

Ralph Rossbach (see Club Roster for addresses, phone numbers, etc.)

Raffle winners Stan Wolpert and Murray Kay

Introduction of visitors

Program chair Joe Levy with update

Librarian Judy Grange

Al Geller with sanding disks to raffle off

Seth Macarthur with winged bowl

Michael Ingham isLycée Français de Shanghai

Shanghai French School (, ) is a private, international school in Shanghai, China, with one campus in the Qingpu District and one campus in Yangpu.

Students range from 3 to 18 years of age and must be of French nationality or already have been taught under the French system. It forms part of the international network of French schools managed by the French government through the Agence pour l'enseignement français à l'étranger (Agency for French Teaching Abroad), a national administrative body.

In 2005, LFS and the German School Shanghai completed a combined "EuroCampus" for their students in Qingpu, Shanghai.

In 2008, LFS opened a new satellite school in Pudong, Shanghai. The school was opened as a primary school and will grow into secondary school year by year


killing anyone. It doesn’t even matter that you’ve only been together for a few months. This is a good kind of change.

“I think my dad likes everyone. Don’t start feeling special yet.”

But you know he’s right. It’s the first time you have seen your dad engage that much with anyone you have brought home- not like you have brought home anyone before anyway.

“Stop hating babe. I’m special and you know it.”

You shrug and walk on ahead of him. The big tree where you once hung a makeshift basketball hoop with your siblings is still there but the hoop is long since gone. You run your hand over the rough bark of the tree until he suddenly appears behind you and places his hand over yours.

“Come with me toon the distance from the 35S enhancer to the TLS of the gene and calculated the ratio of gene activation in detached groups that separated by distance. Statistical analysis showed that the distance between enhancer and TLS of the gene negatively correlated with gene activation ([Fig 3A](#pcbi.1006942.g003){ref-type="fig"}; Table C in [S1 Supplement](#pcbi.1006942.s001){ref-type="supplementary-material"}), implying that distance has the ability to influence the interaction between the enhancer and target gene.

![Correlation analysis of enhancer property and the activation ratio of genes.\
In the interaction between the enhancer and the target gene, we have summarized four properties including. (A) The distance from the 35S enhancer of the T-DNA insertion site to the TLS of gene. (B) Gene orientation. (C) Orientation of T-DNA insertion (enhancer\'s orientation). (D) Location of T-DNA insertion (enhancer's location). US


sequence-specificity related to DISTANCE sequence, resulting in the observation of the overfitting phenomenon in EAT-Rice for gene over a 20 kb distance.

![Performance evaluation in different distance ranges.\
(A) Assessment of EAT-Rice in different datasets. The value of Train, Test A and Test B are corresponding to left Y axis. Train indicates 5-fold cross-validation of training model. Test A indicates the performance of model with the original independent testing data. Test B indicates the performance of model with the new testing data collected after the EAT-Rice had been constructed. STDEV (cross line histogram) is the standard deviation of these three kinds of values, Train, Test A and Test B, and the value of STDEV is corresponding to the right Y axis (STDEV is non-available in the 0--2 range). (B) AssessmentQ:

LINQ many-to-many relationship, how to write a correct WHERE clause?

I use many-to-many relationship for my tables.
There is a query:
var query = from post in context.Posts
        from tag in post.Tags where tag.TagId == 10
        select post;

Ok, it works fine. I get posts having the tag specified by id.
I have a collection of tag ids. And i want to get posts having every tag in my collection.
I try the following way:
var tagIds = new int[]{1, 3, 7, 23, 56};

var query = from post in context.Posts
        from tag in post.Tags where tagIds.Contains( tag.TagId )
        select post;

It doesn't work. The query returns all posts


per Slauma’s clarification. The version below returns posts which contain, at least, all the tags in the tagIds collection.
var query =
    from post in context.Posts
    where tagIds.All(requiredId => post.Tags.Any(tag => tag.TagId == requiredId))
    select post;

Alternate syntax:
var query =
    context.Posts.Where(post =>
        tagIds.All(requiredId =>
            post.Tags.Any(tag =>
                tag.TagId == requiredId)));

Edit2: Corrected above per Slauma. Also including another alternative making full use of query syntax below:
// Project posts from context for which
// no Ids from tagIds are not matched
// by any tags from[Diagnosis of ischemic cardiopathy in ambulatory care patients. Multivariate analysis of clinical and electrocardiographic data].
This study was done on 113 subjects, 93 men and 20 women, whose ages ranged between 32 and 70 years (average 52.9 years). Males varied between 35 and 70 years (average 53.7) and females between 32 and 67 years (average 49.5). Our objective is: to give an account of the different discriminatory methods with mixed data usually used in medical applications, to apply these methods to all the subjects studied with the purpose of comparing their performance and, to develop a protocol for diagnosing coronary artery disease by noninvasive tests. All the subjects were referred for evaluation of chest pain, and were submitted to an exercise test on an ergometric bicycle, selective coronary angiography


THE IMPLIED
 * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
 * DISCLAIMED. IN NO EVENT SHALL APPLE OR ITS CONTRIBUTORS BE LIABLE FOR ANY
 * DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES
 * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES;
 * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND
 * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT
 * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF
 * THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
 */

#pragma once

#include "WebGLExtension.h"

namespace WebCore {

class OESElementIndexUint final : public WebGLExtension {
public:
    explicit OESElementIndexUint(WebGLRenderingContextBase&);
    virtual ~OESElementIndexUint();

    ExtensionName getName() const override;
};

}Strategic Action Plan. Atlanta GA, 2018-Jul-27 — /Travel PR News/ — In a substantial new commitment to wildlife conservation, Zoo Atlanta announces a new partnership with Conservation South Luangwa to protect African elephants and other species impacted by wildlife trafficking and human-wildlife conflict. The partnership… Read the full press release

2013-09-10 — /travelprnews.com/ — Fiona Hyslop, Cabinet Secretary for Culture and External Affairs is this week visiting sites in Argyll which will benefit from funding from Historic Scotland to carry out conservation works. She will today visit the Picture House in Campbeltown, which is celebrating its centenary in 2013. Considered to be Scotland’s oldest continually working… Read the full press release


(CD) — Chanting “resign now” to Bolivia’s interim, self-declared president Jeanine Añez, protesters across the Latin American country on Friday made their displeasure with the overthrow of the government by right-wing Christian extremists last Sunday known.

Thousands of demonstrators marched through the cities of La Paz and El Alto. Friday’s protests follow days of unrest as the Bolivian people rejected Sunday’s coup, which forced democratically-elected President Evo Morales to resign and flee the country.

An Indigenous woman, in comment to RT Thursday, asked if the coup leaders thought the people of Bolivia were ignorant of what was happening in the country.

"¿Creen que somos ignorantes?": El contundente discurso de una mujer indígena a lo que sucede en Bolivia https://t.co/a6TmEMPk7b pic.twitter.com/POCHkQrLxy — RT en Español (@ActualidadRT) November 15, 2019

Friday’s demonstrations were ashow of force by the Bolivian people against the coup government. Video and photographs from the country showed long stretching lines of people waving the Indigenous wiphala flag and calling for Añez to step down.

Protests against the coup d’etat in #Bolivia are getting bigger and bigger. People from all over Bolivia are marching in support of #EvoMorales #BoliviaResiste

pic.twitter.com/PEHf5Nb01A — nonouzi (@Gerrrty) November 15, 2019

A drone recorded a kilometer column of protesters marching through several streets of Cochabamba, Bolivia, in a massive protest to demand the resignation of Jeanine Áñez pic.twitter.com/vpx2EEYyWF https://t.co/4qvuYMQeLm — etienneyerovi (@yerovietienne) November 15, 2019

La Paz, 1:30pm: Mass march against the coup administration and with chants aimed at the police for repressing the Bolivian people to uphold unconstitutionality. @teleSURenglish pic.twitter.com/YzvcP4ORBm — Camila (@camilateleSUR) November 15, 2019

La


time...(more)

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I'm unable to claim a bounty reward in whiterun for killing bandits

I'd received a letter of bounty from Riverwood while searching for a job. I killed all the bandits, and I can officially claim the reward, but since I'm a wanted man, I'm unable to collect my reward. Do I have to pay my dues before receiving the bounty reward? I've been going in circles talking to all the guards to no avail.

A:

In the Elder Scrolls franchise, it very much feels like there's a conditional statement set when interacting with authority. The assumed logic would be something like:
If PC has bounty and bounty region equals current region, then set default dialog for guards to "uphold the law" (criminal scum).
you're best bet is to pay the bounty, and


WASHINGTON (Reuters) - Republicans in the U.S. House of Representatives are pushing to hold Consumer Financial Protection Bureau Director Richard Cordray in contempt of Congress for refusing to respond sufficiently to congressional subpoenas.

Consumer Financial Protection Bureau Director Richard Cordray speaks in Washington, October 17, 2014. REUTERS/Larry Downing

A report released on Friday by Republican staff of the House Financial Services Committee argued there was “ample evidence” to hold Cordray in contempt because of his alleged failure to fully comply with subpoena requests. Republicans on the panel have been fiercely critical of the CFPB’s regulatory work.

The report marked the most direct threat yet to pursue legal action against Cordray, who was appointed by Democratic former President Barack Obama after the agency was created under the 2010 Dodd-Frank financial reform law.

TheDIY, 90s riot grrl and timeless tunes. If these guys do not clear up this year…more fool the general public, frankly.

‘Jail La La’ is forthcoming as a single and is out on February 15, I will Be is out on March 29.

Withered Hand’s debut album, Good News, rightly gained excellent reviews across the board when it was released in September last year. One of many people who’d been blown away by it when I heard it, I got in touch with Dan Willson to meet him face to face for a chat.

When I meet him at Edinburgh’s Southern Cross cafe, Dan comes across as a very warm, friendly guy. Now aged thirty five, he’s been in Edinburgh for thirteen years, living here with his young family. The fact


him. He clearly isn’t relishing the thought of being away from his wife and children for any length of time. Then of course, there’s the matter of actually writing one. “ I write at a glacial pace. I’d rather not write anything than just because someone wants me to write something.” He adds, dreamily, “What I’d really like to do is to write a graphic novel.”

Dan Willson, ladies and gentlemen: treasure him in whatever form you have him.

Withered Hand -‘Religious Songs.’ mp3

Good News and the two EPs ‘You’re Not Alone’ and ‘Religious Songs’ are out now, on SL Records, including from iTunes or direct from SL records.

Next week sees the release of the Factory Kids’ EP1 on February 1, while February 15 sees the re-release of the Wildhouse’sit has been for many, many years. And in 2010, on the strength of their debut EP, this band show that the sick man of Europe is fighting fit when it comes to wonderful music.

January can often seem like a fairly dead month for new music. Part of the reason for this is that people invariably have less money and aren’t going out. I’d be willing to bet that for many whilst resolutions about losing weight, drinking/smoking less etc.. go by the wayside fairly quickly, the money-spending stays low because, well, there isn’t much of it.

There’s been a handful of releases so far this year -both Delphic and Vampire Weekend have already cracked the UK album chart top 10 with their new releases (good, if not amazing), and


to Stuart Braithwaite at an early Franz Ferdinand gig (The Venue, Edinburgh, 2003) and was so in awe I couldn’t bring myself to speak to him. There is a forthcoming film entitled Burning and the live album is called Special Moves. The tracklisting and details of the film can be seen here at their website. As yet there is no release date for the album, other than it’s slated for the spring -oh, and the artwork is designed by one-time labelmate and collaborator, Aidan Moffat! The album is also to be available on triple vinyl. Yum!

2010 is being tipped as being the year of Frightened Rabbit. Their third album, The Winter Of Mixed Drinks, is released by Fat Cat on March 1, 2010 and it is hoped thatexecutive decree.

To be clear, I do not mean to imply that the university stands to profit off this arrangement. The financial details are shrouded in mystery, and what little information I could find suggests that the university donated the housing when the city came calling. I’ve also heard that the city intends to reimburse the university for costs it will incur this week, but that the odds of turning a profit are very slim. This is nothing more than rumor, however, and I only include it to clarify that I am not accusing the CWRU administration of any financial malfeasance. I am only accusing them of their decision to press “pause” on all of our core values.

[blocktext align=”left”]What does it symbolize when a university library closes while security


may be, remains part of the city of Cleveland and the surrounding region. To use President Snyder’s words, I hope that they will rediscover what it means to be “part of this community.” Most of all, I hope that the example of CWRU’s failure will offer my students as much of an education as the one I’m trying to give them in the classroom we’ve been barred from using.

Case Western Reserve University, which “improves and enriches people’s lives through research…and education,” will be ground zero for the storm troopers you will watch on national news next week. When the university realized that this might not be the wisest thing for an institution of higher learning to do, they opted for the solution I’m sure any of us wouldChen, Y. Wang [@ChenWang] and H.-D. Cao, Q. Chen [@CaoChen] proved that a half conformally flat ($W^{\pm}=0$) four-dimensional gradient shrinking Ricci soliton is a finite quotient of $S^4$, $\mathbb{C}P^2$, $S^3\times\mathbb{R}$, or $\mathbb{R}^4$. In [@Wu2], the second author proved that a compact four-dimensional gradient shrinking Ricci soliton with $\delta W^{\pm}=0$ and half two-nonnegative curvature operator (which is equivalent to half nonnegative isotropic curvature) is a finite quotient of $S^4$ or Kähler-Einstein.

In this paper we complete the classification of four-dimensional gradient shrinking Ricci solitons with harmonic half Weyl curvature,

\[Thm1.1\] A four-dimensional gradient shrinking Ricci soliton with $\delta W^{\pm}=0$ is either Einstein, or a finite quotient of $S^3\times\mathbb{R}$, $S^2\times\mathbb{R}^2$, or $\mathbb{R}^4$.

As opposed to the locally conformally flat or half-locally conformally flat conditions we note that all Einstein metrics satisfy $\delta W


to dig through the trash to find an envelope that was sent to me so I could remember my own address - especially since I lived in the same place for the last nine years!

One of these days, I would have been in choir at church and the rest of them would have started singing the song we had been practicing for three weeks while I would probably would have started singing the Star Spangled Banner. And even worse... I would probably have gone all Christina Aguilera on it.

Someday, I would fall down the stairs or slip in the bathtub or get caught walking in a never-ending circle or driving to the store only to end up in Maine. And, nobody would know the difference - at leastBioaccumulation of melamine in catfish muscle following continuous, low-dose, oral administration.
In this study, catfish muscle was analyzed for melamine (MEL) and cyanuric acid (CYA) residues following experimental feeding with low doses of MEL and MEL and CYA (MEL+CYA) and with the insoluble melamine-cyanurate complex (MEL=CYA). Catfish were daily fed 0.1 mg/kg BW of MEL for 15, 28, or 42 days, 0.1 mg/kg BW of MEL+CYA for 28 days, 2.5 mg/kg BW of MEL+CYA for 14 days, or 400 mg/kg BW of MEL=CYA for 3 days. Residues in the tissue were determined by LC-MS/MS. MEL was extracted with acidic acetonitrile, followed by defatting with dichloromethane, and isolated with cation exchange solid phase extraction (SPE). For CYA analysis, fish were extracted with dilute acetic acid, defatted with hexane, and cleaned


the home state for the purposes of the statute so long as the

six-consecutive-month period ends within six months prior to the commencement of the child

custody proceeding. Rosen, 117 Ohio St.3d 241, 2008-Ohio-853, 883 N.E.2d 420, at ¶ 32.

          {¶13} We agree with father that under the home-state determination, Ohio does have

jurisdiction to hear the matter. Here, father did not know the whereabouts of his children until

February 2011. After learning they were in New Jersey, he immediately filed his custody

application.2 At the time he filed his custody application, the minor children had lived with him

in Ohio from January 2008 to September 2010. Thus, the children had lived in Ohio for at least

six consecutive months, ending within the six-month period beforeHartman, 8th Dist. No. 75855, 1999 WL 1206581 (Dec. 16,

1999) (where this court held that the trial court did not abuse its discretion in declining to

exercise jurisdiction when the trial court determined Florida to be the home-state of the child

after specifically stating its reasons why Florida is the most convenient forum for the parties.)

Therefore, we find the trial court abused its discretion when it declined to exercise jurisdiction,

without explicitly determining that it is an inconvenient forum under the circumstances.

       {¶16} Accordingly, the sole assignment of error is sustained.

       {¶17} Judgment reversed and the matter remanded for further proceedings consistent with

this opinion.

       It is ordered that appellant recover from appellee costs


in HIV-infected patients include the following:

Jaundice and kidney stones in people taking IDV, although these side effects are infrequent when IDV is taken for less than one month. The risk of kidney stones may be reduced by drinking 48 oz of fluid per 24-hour period.

There is some information about ZDV use by health-care workers as postexposure treatment. ZDV is usually tolerated, but reported side effects have included upset stomach, tiredness, and headache, all of which stopped when the drug was stopped. There is little information on the side effects of 3TC or IDV in uninfected individuals.

Should pregnant health-care workers take these drugs?

Based on limited information, ZDV taken in the second and third trimesters of pregnancy has not caused serious side effects in mothers or infants. There is veryweeks, with each team receiving two bye weeks, instead of one. The league would get an extra week of national media revenue, and the players would get an extra week off while playing the same number of games.

Now, wait a minute. Didn't the NFL try the two-bye system for a year when I was three years old? (Thank you, Bill Simmons, for reminding me.) They did, and after ratings underperformed, the NFL changed it back the following year. But the NFL on television is a different game now than it was in 1993. NFL television ratings are as strong as ever. The league earns roughly $4 billion a year in television revenue, more than 140 percent increase from the early '90s (taking inflation into account). While most NFL


their favorite teams; they watch their favorite players, football in general, or the point spreads. Besides, with a lockout looming, people will accept missing one week of watching the local boys over missing an entire season. This solution won't fix the current CBA negotiations, but it's one painless way of growing the pie that both sides could live with.48 h, had the same tendency. As manganese concentration increased, the mRNA expression of the heat shock proteins first increased and then decreased. In other words, we demonstrated that the mRNA expression of the heat shock proteins was induced at lower concentrations of manganese and was inhibited at higher concentrations. Mn had a dosage-dependent effect on HSP27, HSP40, HSP60, HSP70, and HSP90 mRNA expression in chicken spleen lymphocytes in vitro.


to each other, which was handled as a single mutation in the downstream analysis (Table [2](#Tab2){ref-type="table"}). All mutations but one were previously recorded in COSMIC (Catalogue Of Somatic Mutations In Cancer); however five of the patients scored neutral or NA in the Functional Analysis through Hidden Markov Models (FATHMM)^[@CR25]^ scoring by GEMINI (GEnome MINIng). MAFs in the tumours ranged between 8--85% with a median of 64% (Table [3](#Tab3){ref-type="table"}).Table 2Mutation characteristics.PatientProtein ChangeMutation TypeCHRStart PositionEnd PositionReference AlleleVariant AlleleCOSMIC IDFATHMM1TP53 - V10IMissense Mutation1775798857579885CTCOSM45361Neutral2TP53 - Q136EMissense Mutation1775785247578524GCCOSM43767Pathogenic3TP53 - Y163CMissense Mutation1775784427578442TCCOSM10808Pathogenic4TP53 - P151SMissense Mutation1775784797578479GACOSM10905Pathogenic4TP53 - T150TSynonymous Mutation1775784807578480TANANA5TP53 - C242FMissense Mutation1775775567577556CACOSM10810Pathogenic6TP53 - R333fsFrame Shift Deletion1775740307574030G-COSM69084NA7TP53 - P273LMissense Mutation1775771207577120CACOSM10779Pathogenic8TP53 - C242\*Nonsense Mutation1775775557577555GTCOSM44378Pathogenic9TP53 - E294\*Nonsense Mutation1775775147577515CACOSM10856NA10TP53 - Q52fsFrame Shift Deletion1775795327579533TG-NA11TP53 - C176YMissense Mutation1775784037578403CTCOSM10687Pathogenic12TP53 - R213fsFrame Shift Deletion1775782137578213A-COSM5016718NA13TP53 - R175HMissense Mutation1775784067578406CTCOSM10648Pathogenic14TP53 - G244VMissense Mutation1775775507577550CACOSM43652Pathogenic15TP53 - G245VMissense Mutation1775775477577547CACOSM11196PathogenicFATHMM: Functional Analysismutations in the diagnostic sample from patient 3 but was able to detect mutations in the diagnostic samples from patients 8 and 9 (Table [3](#Tab3){ref-type="table"}, Fig. [2B](#Fig2){ref-type="fig"}). The calculated MAF in the diagnostic sample from patient 8 (0.0089%) was below the theoretical limit of detection of the Bio-Rad assay^[@CR21]^.

Despite the age and the low abundance of DNA in the archival samples, the IBSAFE method was successful in all the individual assays, measuring concentrations comparable to the QUBIT assay (Tables [1](#Tab1){ref-type="table"} and [3](#Tab3){ref-type="table"}, Fig. [2C](#Fig2){ref-type="fig"}). Furthermore, we were able to detect a tumour corresponding mutation in the archival samples from patients 1 and 13 (sample 13C). Patient 13 was diagnosed with a stage IIIB tumour and had a total of three archival samples (13A, B and C) collected 46, 32 and 20 months


gym after work! Strength training will be the majority of my work out and you gotta have extra muscle milk for those muscles!

In the mix:

1 frozen banana

1 c. frozen mango

1 handful fresh spinach

1/2 scoop chocolate protein powder

1 c. combined chocolate almond milk and vanilla soy milk

I really need to invest in a good blender, I get spinach chunks in my smoothies…yuck. I’ve been using a food processor- I know. Not the best idea, especially when frozen banana causes the smoothie to come out of the sides and splatter.Any good blender recommendations out there?

About Alexa

Hi! I'm Alexa, and I'm a 27-year-old living and working in Elmsford, NY. I dream about food, cooking and could bake all day long if you let me. If you have any suggestions, comments, orin \>30% (≥4/13) of individual ARS deficiencies were considered common among ARS deficiencies.

Results {#Sec3}
=======

We identified 107 children with homozygous or compound heterozygous pathogenic variations in 10 different cytosolic and 3 combined cytosolic and mitochondrial *ARS* genes (Fig. [1](#Fig1){ref-type="fig"}, Table S[1](#MOESM2){ref-type="media"}). All reported ARS deficiencies were associated with affected central nervous system (CNS) and/or senses (hearing/sight), most with failure to thrive (10/13) and many with feeding problems (6/13), dysmaturity (5/13), and liver symptoms (4/13). Signs of mitochondrial dysfunction and facial dysmorphisms were common (6/13 and 4/13, respectively, including all three combined cytosolic and mitochondrial ARSs) and various endocrine abnormalities (4/13). Symptoms were most severe in the first year of life (4/13) and during infections and included acute liver failure and status epilepticus and/or encephalopathy (4/13).Fig. 1Clinical symptoms of patients with


autosomal recessive ARS deficiencies reported in literature (left part) and supplemented with P1--5 (right part).Gray squares represent symptoms reported for 1 patient, black squares symptoms reported for \>1 patient. Categories of symptoms occurring in \>30% of the individual ARS deficiencies are marked in orange for patients reported in literature and in red after addition of P1--5. MRI magnetic resonance imaging, LVH left ventricular hypertrophy

We additionally identified five patients with pathogenic variations in *ARS* genes (nomenclature according to Human Genome Variation Society \[HGVS\] guidelines):P1, female, died at age 4 months, compound heterozygous pathogenic variations in *IARS* (NM_002161.5): c.1305G\>C p.(Trp435Cys) and c.3377dup p.(Asn1126fs)P2, male, now age 5 years, compound heterozygous pathogenic variations in *IARS* (NM_002161.5): c.1305G\>C p.(Trp435Cys) and c.3377dup p.(Asn1126fs). The parents originate from the same region as P1, whichan estimated developmental age of 4 months at age 4 years, involving eye contact, intentional laugh, recognition of parents, hypotonia, bipyramidal syndrome combined with extrapyramidal movements, but no rolling nor independent sitting. P5 had an estimated developmental age of 9 months at age 3.5 years, involving independent sitting and standing with support, but no crawling, language development, or interest in toys. Both patients had severe epilepsy. P4 had a permanent electroencephalogram (EEG) pattern of a (non)convulsive status epilepticus and from the age of 6 months jerky movements of the extremities, head, and/or eyes, somewhat improving with levetiracetam and clonazepam. P5 had a refractory epileptic encephalopathy despite ketogenic diet, deteriorating with vaccination/infections. In addition, P4 had severe perceptive hearing deficit, treated with cochlear implants and P5 severe occipital visual


disturbance, with random eye movements and almost absent eye fixation or following.Fig. 2Growth curves of weight, length, and head circumference of P1--5.Arrows indicate hospitalization due to feeding problems requiring nasogastric tube feeding (P1--4). Striped bars represent periods of feeding by percutaneous endoscopic gastrostomy (P2, P3, P5) or nasogastric tube (P4). Notice that the ranges of the *x*-axes are not synchronized between patients due to age differences

Symptoms were milder in P1--3. Due to young age and hospitalization, development in P1 was difficult to judge. She was hypotonic, alert, made good eye contact, and passed her hearing test. P2--3 showed evidence of delayed global development (P2: global hypotonia, developmental quotients for global development, motoric skills, and verbal capacities ranging from 49 to 75 at age 3.5 years; P3: motor functioningnigra. In P5, brain MRI was relatively normal at age 3 months, but displayed delayed white matter myelination, gradual loss of frontal periventricular white matter, and a relatively thin corpus callosum at age 1 year. At autopsy, microscopic evaluation of the brain of P1 (age 4 months) showed sparse white matter with decreased occipital myelination of U fibers. Neuronal damage, presumably toxic, was seen in the basal ganglia and thalamus and minor recent hypoxic/ischemic damage in cerebellar neurons.Fig. 3Radiologic and histologic findings.(**a**) Brain magnetic resonance image (MRI) scans of P3, P4, and P5. T2-weighted axial and T1-weighted coronal MRI in P3 at age 4.5 years show focal atrophy of the cerebellar cortex. T2-weighted MRI in P4 at age 11 months shows abnormalities in the substantia nigra. T1-weighted MRI


acid concentrations (maximally 3.11µmol/L; reference range: 0.12--0.25 µmol/L; and 102 mmol/mol creatinine; reference range: 0--20 mmol/mol creatinine, respectively) at age 3 months; there was no evidence of nutritional deficiencies with normal vitamin B12 and homocysteine concentrations. All abnormalities normalized with age.

Metabolic investigations were performed in P3 at age 13 months upon presentation with hypoglycemia, abnormal liver enzymes, and status epilepticus. She displayed elevated cerebrospinal fluid (CSF) lactate concentrations, but normal lactate/pyruvate ratio and alanine concentrations. Urinary lactate and pyruvate excretion were elevated, but organic acid excretion was normal. Oral glucose tolerance test showed a slight rise in lactate and low--normal ketone body production. Muscle biopsy revealed decreased substrate oxidation velocity and ATP + CrP production (10.9 nmol/h.mUCS, reference range: 15.4--30.2 nmol/h.mUCS), but normal enzyme activities of all respiratory chain enzymes, complex V, pyruvate dehydrogenase complexhand there is some excess capacity in ARS activity.Fig. 5Putative disease mechanism for autosomal recessive ARS deficiencies.(**a**) Overview of the pathogenic variations found in autosomal recessive ARS deficiencies, concentrated in the domains associated with the canonical function in protein translation. The novel pathogenic variations described for P1--P5 are underlined. (**b**) Schematic representation of the putative disease mechanism: insufficient aminoacylation to meet translational demand in specific organs or periods. tRNA transfer RNA

Intrauterine growth restriction and failure to thrive seem closely related to a disease mechanism involving reduced aminoacylation activity, translational slowdown or inefficiency, and consequential decreased proliferation. Indeed, growth was diminished in complementation assays in yeast with mutant *AARS*,^[@CR31]^ *IARS*,^[@CR36]^ *MARS*,^[@CR34]^ *GARS*,^[@CR50]^ and *KARS* ^[@CR53]^ alleles. Similarly, hypoalbuminemia would well align with this disease mechanism, because albumin synthesis is


for cytosolic ARS deficiencies, involving CNS abnormalities, growth restriction, liver symptoms, and facial dysmorphisms. This highlights the importance of deep phenotyping in patients with novel rare genetic diseases. Identification of a common clinical phenotype implies that recessive pathogenic variations in newly identified cytosolic ARSs may result in similar clinical symptoms, which might improve disease recognition and guide diagnostic work-up. Insufficient aminoacylation activity to meet high translational demand as common disease mechanism would also guide therapeutic care. As some residual enzyme activity seems essential for life, adequate supply of protein/amino acids is crucial, especially during periods of increased translational demand, including the first year of life and infections.

Electronic supplementary material
=================================

 {#Sec15}

Supplementary Table Legends Supplementary Table S1 Supplementary Table S2

These authors contributed equally: Imre F. Schene, Gautam Kok.

Electronic supplementary material
=================================

Thedecision for me and my future. It has been a dream of mine to play in the NBA, and I feel excited and well prepared to take that next step in my career.

“My time at Michigan has helped me grow tremendously as both a basketball player and as a person. I will always be grateful for the opportunity Coach Beilein and his staff gave me to wear the Maize and Blue. I have learned so much from this staff and this university about what is really important if you want to be successful in your future. I love the University of Michigan and the Ann Arbor community, and it will always be a place I call home.

“I’d like to thank my teammates, my coaching staff, my family and


Palestinian civilians: “Israel has the right to defend itself.”

The German Foreign Ministry, while expressing its “concern” about the use of live rounds against peaceful protesters, declared that “the right to peaceful protest” must “not be abused” by the Palestinian leaders, who, it implied, used the demonstrations as a pretext to “deploy violence.”

“Those who wield power in the Gaza Strip must renounce violence and the Palestinian Authority must once again be in control in Gaza,” the Foreign Ministry added.

UK Prime Minister Theresa May echoed these sentiments, declaring, “We are concerned that extremist elements” within Gaza “may be seeking to hijack peaceful protests to further their own objectives.”

French President Emanuel Macron, who went further in criticizing Israel’s actions than other leaders, reaffirmed his “commitment to the security of Israel.”

Within theGot any old Disney films lurking around your home? Please burn them immediately, lest they do irreparable damage to your daughters. This advice doesn’t come from me, by the way, it comes from Keira Knightley. During a recent appearance on the US talkshow Ellen, the actor said she has banned her three-year-old girl from watching Cinderella and The Little Mermaid because of how they portray women. Cinderella is “banned because she waits around for a rich guy to rescue her”, Knightley said. “Don’t! Rescue yourself.” As for The Little Mermaid: “The songs are great, but do not give your voice up for a man. Hello!”

Knightley isn’t the only Hollywood actor sharing her super-woke thoughts about Disney feminism. Kristen Bell recently told Parents magazine that Snow White sends the


be listed by name. Other relatives need not be mentioned by name but may be referenced in terms of their relationship to the deceased: for example, the obituary may say that the deceased leaves behind five grandchildren, seven nieces, etc.

Scheduled Services

Provide details of the scheduled services, including the time, date and address. These may include the funeral, visitations, burial and memorial service as applicable.

Memorials

Give the name and mailing address of a foundation or society to which you wish to direct any memorial donations made in honour of your loved one. The decision as to which foundation or society to support may be based upon interests or values that your loved one expressed during life or related to a medical condition which he or she had. We recommend youcopyright in the Fellini film. The film was released in the United States in 1961 and there was extensive media coverage of the opening. (Butterfield Decl. Ex. 14, Feb. 1, 2008.) This evidence lends credence to the defendants' argument that Cinemat could not have conveyed its interest to Hor in 1980 when the film had opened so publicly in the United States through a chain of title that is inconsistent with Cinemat continuing to hold the copyright. Moreover, Republic registered a restored copyright in the film in 1998. IMF received notice of the Republic registration when IMF filed its registration in December 2002. All of this evidence lends support to the defendants' argument that IMF does not hold the copyright to the Fellini film.
In any event, the plaintiff


Richard de Groen

Richard Paul de Groen (born 5 August 1962) is a former New Zealand international cricketer. He played five Test matches and 12 One Day Internationals for New Zealand in 1993 and 1994.

De Groen was born at Otorohanga in Waikato and played domestic cricket for Auckland and Northern Districts between the 1987/88 and 1995/96 seasons.

References

Category:1962 births
Category:Living people
Category:Auckland cricketers
Category:New Zealand One Day International cricketers
Category:New Zealand Test cricketers
Category:New Zealand cricketers
Category:Northern Districts cricketers
Category:People from Otorohangathe war." "They think we have the Ring." "As soon as they find out we don't, we're dead." "Just a mouthful..." "... abitof theflank." "Looks like meat's back on the menu, boys." "Pippin." "Let's go." "Go on." "Call for help." "Squeal." "No one's going to save you now." "Pippin!" "A red sun rises." "Blood has been spilled this night." "Riders of Rohan..." "... whatnewsfromthe Mark?" "What business does an Elf, a Man and a Dwarf have in the Riddermark?" "Speak quickly!" "Give me your name, horse-master, and I shall give you mine." "I would cut off your head, Dwarf..." "... ifitstoodbut alittlehigher from the ground." "You would die before your stroke fell." "I am Aragorn, son of Arathorn." "This is Gimli, son of Glóin, and Legolas of the


they?" "They passed this way the day before yesterday." "They met someone they did not expect." "Does that comfort you?" "Who are you?" "Show yourself!" "It cannot be." "Forgive me." "I mistook you for Saruman." "I am Saruman." "Or rather, Saruman as he should have been." "You fell." "Through fire..." "... andwater." "From the lowest dungeon to the highest peak..." "... I foughtwiththe Balrog of Morgoth." "Until at last I threw down my enemy..." "... andsmotehis ruin upon the mountainside." "Darkness took me..." "... andIstrayedoutofthought and time." "Stars wheeled overhead..." "... andeveryday was aslong  as a life age of the Earth." "But It was not the end." "I felt life In me again." "I've been sent back..." "... untilmy taskisdone ." "Gandalf." "Gandalf?" "Yes." "That was whatthe falling of small stones..." "... thatstartsan avalanche in the mountains." "I n one thing you have not changed, dear friend." "You still speak in riddles." "A thing is about to happen that has not happened since the Elder Days." "The Ents are going to wake up..." "... andfindthattheyarestrong." "Strong?" "!" "Oh, that's good." "So stop your fretting, Master Dwarf." "Merry and Pippin are quite safe." "I n fact, they are far safer than you are about to be." "This new Gandalf's more grumpy than the old one." "That is one of the Mearas..." "... unlessmy eyesare cheated by some spell." "Shadowfax." "He is the lord of all horses..." "... andhasbeenmyfriend through many dangers." "O rowan mine" "I saw you shine" "Upon a summer's day" "Upon your head


you." "Hearken to me!" "I release you..." "... fromthespell." "You have no power here..." "... GandalftheGrey." "I will draw you, Saruman, as poison is drawn from a wound." "Wait." "If I go, Théoden dies." "You did not kill me..." "... youwillnotkillhim." "Rohan is mine." "Be gone." "I know your face." "Éowyn." "Éowyn." "Gandalf?" "Breathe the free air again, my friend." "Dark have been my dreams of late." "Your fingers would remember their old strength better..." "... iftheygraspedyoursword." "I've only..." "... everservedyou,mylord ." "Your leechcraft would have had me crawling on all fours like a beast!" "Send me not from your sight." "No, my lord!" "No, my lord." "Let him go." "Enough blood has been spilt on his account." "Get out of my way!" "Hail, Théoden King!" "Where isnow by fear of Sauron." "Ride out and meet him head on." "Draw him away from your women and children." "You must fight." "You have 2000 good men riding north as we speak." "Éomer is loyal to you." "His men will return and fight for their king." "They will be 300 leagues from here by now." "Éomer cannot help us." "I know what it is you want of me..." "... butI willnotbringfurtherdeath  to my people." "I will not risk open war." "Open war is upon you, whether you would risk it or not." "When last I looked..." "... Théoden,notAragorn, was king of Rohan." "Then what is the king's decision?" "By order of the king..." "... thecitymustempty." "We make for the refuge of Helm's Deep." "Do not burden


"This thing must come to Gondor." "Gondor." "It's dangerous, I know." "Ever the Ring will seek to corrupt the hearts of lesser Men." "But you, you are strong." "And our need is great." "It is our blood, which is being spilled, our people who are dying." "Sauron is biding his time." "He's massing fresh armies." "He will return." "And when he does, we will be powerless to stop him." "You must go." "Bring me back this mighty gift." "No." "My place is here with my people." "Not in Rivendell." "Would you deny your own father?" "If there is need to go to Rivendell..." "... sendmein hisstead." "You?" "Oh, I see." "A chance for Faramir, captain of Gondor, to show his quality." "I think not." "I trust this missionand the gate from above." "No army has ever breached the Deeping Wall..." "... orsetfootinsidetheHornburg!" "This is no rabble of mindless Orcs." "These are Uruk-hai." "Their armour is thick and their shields broad." "I have fought many wars, Master Dwarf." "I know how to defend my own keep." "They will break upon this fortress like water on rock." "Saruman's hordes will pillage and burn." "We've seen it before." "Crops can be resown..." "... homesrebuilt." "Within these walls..." "... wewilloutlastthem." "They do not come to destroy Rohan's crops or villages." "They come to destroy its people..." "... downtothelastchild." "What would you have me do?" "Look at my men." "Their courage hangs by a thread." "If this is to be our end, then I would have them make such an


put into songs or tales." "What?" "I wonder if people will ever say, "Let's hear about Frodo and the Ring."" "And they'll say, "Yes!" "That's one of my favorite stories."" ""Frodo was really courageous, wasn't he, Dad?"" ""Yes, my boy." "The most famousest of Hobbits." "And that's saying a lot"" "Well, you've left out one of the chief characters:" ""Samwise the Brave"" "I want to hear more about Sam." "Frodo wouldn't have got far without Sam." "Now, Mr. Frodo, you shouldn't make fun." "I was being serious." "So was I." ""Samwise the Brave"" "Sméagol?" "We're not going to wait for you." "Come on." "Master." "Master looks after us." "Master wouldn't hurt us." "Master broke his promise." "Don't ask Sméagol." "Poor, poor Sméagol." "Master betrayed us." "Wicked." "Tricksy." "False."rallies.

edit: I guess they are meant to be here
[http://www.cnccfp.fr/index.php?art=584](http://www.cnccfp.fr/index.php?art=584)

~~~
heyts
Accounting breakdown for the 2017 election is not yet available, apparently.
This page list accounting breakdown for the 2012 and 2007 presidential
elections:
[http://www.cnccfp.fr/index.php?art=720](http://www.cnccfp.fr/index.php?art=720)

I also would be curious to know the production and operating costs for a
website of this kind.

------
acoard
This was a fantastic read, thanks for sharing.

Was the Kubernetes cluster necessary/useful for this sort of architecture? I'm
asking as someone who has basically no experience with Kubernetes, but I'm
familiar with the rest of the pieces.

>As any other high-profile web site, we were the target of some attacks
coordinated and carried out by powerful organizations. Most of the attacks
were of brute-force nature and the aim was to take the web site down rather
than infiltrate it.

I'm surprised that the attacks were just brute-force attacks. Assuming state
actors wanted


alien, Varossa. They live in a society without books where they memorise everything. In the second series the children have to enlist the help of the Australian Prime Minister when Peter is kidnapped by the alien, and a procession of intrigues eventually leads them to the aliens' home planet of Soshuniss.

Production
The Stranger was written by New Zealand-born author G.K. Saunders, produced by Storry Walton and directed by Gil Brealey, with production design by Geoffrey Wedlock. Two series of six episodes each were produced in 1964 and 1965. It was a major hit in Australia and was sold to the BBC.

The series starred leading stage and radio actor Ron Haddrick as "The Stranger", Adam Suisse; the children were played by Janice Dinnen and Bill Levis as Jean and Bernardthe total number of U.S. citizens killed in the Brussels attacks to four. Justin and Stephanie Shults moved to Belgium in 2014. They were from Gatlinburg, Tennessee, and Lexington, Kentucky. Both were accountants. (NBC)

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Alaska’s Pavlof Volcano began erupting, sending ash 20,000 feet high and prompting flight warnings. ( . ( CNN The PEZ Candy Company abruptly canceled its annual Easter egg hunt in Connecticut after parents wreaked havoc on the event: one child suffered a bloody nose after allegedly being pushed to the ground by an adult. Others reported broken Easter baskets in the scuffle. ( Others reported broken Easter baskets in the scuffle. ( Hartford Courant An American Airlines pilot was arrested in front of passengers after failing a sobriety test ON THE RUNWAY, moments


ten most dangerous cities in America,’ the petition states. ‘By forcing attendees to leave their firearms at home, the RNC [is] putting tens of thousands of people at risk both inside and outside of the convention site.’” HOT ON THE RIGHT “Obama plays at least 46 full days golf,” from the Washington Examiner: “President Obama, fresh from his whirlwind spring break trip to Cuba and Argentina, hit the links for some R&R Saturday, playing his 281st round since becoming president. That is slightly more than three quarters of a year of days playing the presidential sport for Obama. The president typically plays for at least four hours, sometimes longer, putting his time at over 1,100 hours golfing, or at least 46 full 24-hour days.”

DAYBOOK:

On the campaign trail: ThreeWashington. But when Jordan’s mother spoke to the president, he told her he had no interest in accepting an African American woman … Now, more than half a century later, the school that once turned her away is honoring her with one of its most prestigious awards. On March 14, Jordan received the school’s Monroe Medal, which acknowledges ‘extraordinary career achievement used to benefit humanity and society.’ ‘People need to take the initiative to do something,’ Jordan said. ‘You might fail, but your failure can open doors for others. We don’t succeed at everything, but suppose no one tries, suppose no one had applied.’”

-- Maryland lawmakers are weighing legislation to address gender pay inequities in the state. The median annual salary for Maryland women is $50,481, or 85


Send To Options — for word processing and spreadsheet programs

You can send a scanned document to a word processing program, such as Microsoft Word, Write or Notepad, or to a speadsheet program such as Excel, on theSend To bar.

This lets you use PaperPort’sOCRprogram to convert the scanned text into a document that you can edit in your word processing program. An OCR program reads, interprets and converts scanned characters into actual editable text.

Right-click the program icon and then clickSend To Optionsto display theSend To Optionsdialog box. In the dialog box for your word processing program, you can specify:

The file type for converted text documents.PaperPort automatically chooses the default file type for the word processing program. This ensures that the word processing program can successfully open and display theIn general, a System on Chip (SoC) used in communication systems controls power by using several methods for reducing power consumption. When the SoC is used in a Wireless Personal Area Network (WPAN), the SoC operates in an active state for a short period of time and operates in a sleep state for most periods of time to minimize power consumption.
A control method for reducing power consumption of the SoC may be implemented in a software manner. However, an operation of a Central Processing Unit (CPU) and the use of program memories may increase power consumption. Therefore, in general, it is more effective to implement the control method in a hardware manner.
There are three representative conventional methods for reducing power consumption in a hardware manner. In a first


is among several legal arguments raised in a high-profile civil lawsuit before the U.S. Court of Appeals for the 6th Circuit on Thursday. It was filed by Hall and six other Detroit school students.

A three-judge panel is set to hear oral arguments in Cincinnati in the 2016 case in which the Detroit students allege a lack of books, classrooms without teachers, deplorable building conditions and extreme temperatures deprived them of their right to access literacy in their public schools and should be remedied by the court.

The class-action lawsuit, which is seen as an unprecedented attempt to establish that literacy is a U.S. constitutional right under the 14th Amendment, is being closely watched by education, legal and civil rights experts with some saying it could make its way toof the litigation, said the Detroit case gives the federal court system a chance to consider what he called the "massive body of evidence" demonstrating what under-funded schools do to the children attending them, including making them a "permanent underclass," a term referenced in a prior U.S. Supreme Court ruling involving education.

Tribe said every state makes K-12 education mandatory and basic education has been recognized unanimously by the Supreme Court as “necessary to prepare citizens to participate effectively and intelligently" in an open political system.

The Detroit students' case is unique, Tribe said, because it makes an innovative legal claim that Michigan — through its governor, state education department and others — has violated the 14th Amendment’s equal protection clause by effectively excluding them from the state’s system of


law expert and an associate professor of law at Wayne State University Law School, said the case has "zero likelihood of success" in federal court because the legal questions raised by attorneys for the students have already been answered by the U.S. Supreme Court.

"The federal claim is just a loser," Long said. "(SCOTUS) said there is no federal constitutional right to literacy. The 6th Circuit will come out the same way. I don’t think it will get to Supreme Court."

Long said as a state constitutional law expert and father of a child attending a Detroit school, he strongly believes there needs to be a right to access literacy, and it needs to be judicially enforced.

"We do have a right to access literacy. It’s not located in the U.S.lead attorney for the students in the case and director of Public Counsel’s Opportunity Under Law, said the lawsuit is the first federal case in the nation to seek to vindicate the right of all students to access to literacy, regardless of what state or city they live in.

“We are not talking about labs that split atoms. We are talking about the basics like teachers and books and facilities where kids need to learn," Rosenbaum said of the conditions the Detroit students endured.

"You cannot compel children to be inside a government building for six to seven hours a day and warehouse them, when a stone throw away, they are getting an education that would fit a college student,” Rosenbaum said.

The appeal focuses on two areas, Rosenbaum said: first


to restore local control for the school district. Vitti came to the district a year after the lawsuit was originally filed.

"This lawsuit ... speaks to years of educational injustice in Detroit linked to imposed governance structures that stripped the city of local control, low student achievement and disinvestment in children and employees who serve them," Vitti said.

"No district in this country experienced the brutal history of what DPS endured, more importantly, what children endured. No state government, regardless of legal interpretation, can morally say children do not have a right to literacy."

During emergency management, Vitti said students were denied a strong public education, and there must be accountability for that.

"The state took over the district, without the people's consent, and the district went backwards," he said. "Adults needis greater: 8 or f?
8
Suppose 0*f + 2*f = 488984. Let j = -1706105/7 + f. Let w = 764 - j. Which is smaller: w or 2?
w
Suppose 19 = 6*n + 43. Which is greater: n or -11?
n
Let d be 1568/21 + (-2)/(-6). Suppose -3*v + y + d = 0, -3*v + 4*y = 2*y - 72. Is v at most 25?
False
Let s be (21/20)/7*-2. Let a(u) = -u**2 + 6*u + 1. Let n be a(6). Let w = n + -1. Does s = w?
False
Let w(j) be the second derivative of -j**3/6 + 3*j**2 - 2*j. Let r be w(14). Which is bigger: r or -1?
-1
Let v be 0 + (-3)/6*0. Suppose v = -12*i - 12 - 24. Suppose y - 1 =


Let h be (-220)/18 - b/(-108). Let j be (-2*1)/(6/39). Does h = j?
False
Let v be ((-2)/(-5))/((-468)/(-260)). Which is bigger: v or 0?
v
Let q = -12/275 - -1/75. Suppose -4*n + 308 = -11*n. Let c = 45 + n. Are c and q equal?
False
Let g(p) = -22*p - 666. Let b be g(-30). Is 183 greater than or equal to b?
True
Let y be -2*2/12 - 56/(-6). Suppose y*k = 135 - 45. Let r(j) = 2*j + 1. Let s be r(5). Which is smaller: s or k?
k
Let p be (-978)/8 + 3 + 0. Let h = 120 + p. Which is bigger: 0 or h?
h
Let h(i) = 145*i**3 + i**2 - 2*i - 3. Let t be h(-1). Which is bigger: t or 1?
1
Let wQ:

Constructor overloading for two types

I am making a class User. I have done some constructor overloading below:
class User
{
    public:
    explicit User(string firstInit, string secondInit){
        this->firstInit = firstInit;
        this->secondInit = secondInit;
    }//end constructor

    explicit User(char firstInit, char secondInit){
        this->firstInit = firstInit;
        this->secondInit = secondInit;
    }//end constructor

    explicit User(string firstInit, char secondInit){
        this->firstInit = firstInit;
        this->secondInit = secondInit;


be one of those enum?

A:

So you have either a single char or whole std::string. Since std::string can also be used to hold a single char, I suggest to use the following:
class User
{
private:
    std::string first;
    std::string second;

public:
    explicit User(std::string firstInit, std::string secondInit) :
        first(firstInit),
        second(secondInit)
    {
        //Only this constructor actually initializes any variables.
    }

    explicit User(char firstInit, char secondInit) : User(std::string({ firstInit }), std::string({ secondInit }))
    {
    }

    explicit User(std::string firstInit, char secondInit) : User(firstInit, std::string({ secondInit }))
   many diuretics and now you're dehydratedand cramping." "That's why you fell." "I need a bananafor some potassium." "Zack,we are waypast bananas and tea." "All those diureticsmade you ototoxic." "Temporarily deaf.You can barelyhear me,right?" "Those blockersmake me feel like crap." "I take them,I miss deadlines,and eventually our publisher'sgonna drop us." "I can't affordto play russian roulette with our livelihood." "Well,you're playing russianroulette with your life." "I got to make a living,hank." "Look,I get it.I do." "But if you don'ttake your meds,you could developa severe arrhythmia." "I'm your doctor.You need to listen to me." "What?" "You need to listen to me." "Don't you guys havea triplea discount?" "Coupon in the paper?" "Twoforone special?" "Anything?" "We're here to keep yourhusband alive,ma'am,not steam clean your carpets." "Fine." "Here's a check for half."


commentsection included." "I'll see you at home." "So you've finally realizedyou bit off more than you can chewwith my loving,stubbornashell husband." "No,I realize that youand I want the same thing and we can help each other." "And how's that?" "By convincing zackthat he needs to be your husband first and your illustrator second." "Zack?" "He locked it again." "He gets like this beforeevery deadline." "Zack,open up,buddy." "Even I don't get a key." "The good news is the kitchenand the bathrooms are all on this sideof the door, so eventually he hasto come out." "Zack!" "Zack!" "Open the door,zack!" "What's happening?" "It's calleda flash pulmonary edema." "This fluid's comingfrom his lungs." "Uh,grab that bag,please." "Oh,please." "Don't leave me,sweetie." "Please." "I need you." "It's gonna be okay." "Stay with me,zack.""How's my super fly guy?" "The P.A.ThinksI'll be better by?" "Oh,right here." "Oh,well,that's duringmy trinidad photo shoot." "What would you thinkif I met you in trinidad and we flewto the real amazon?" "You'd really geting an airplane for me?" "With enough sedation,sure." "Look,if something this weirdcan happen in the hamptons, what am I so afraid of,huh?" "Oh,baby." "Oh,my big,strong man." "Oh,my gosh,I just love you so much,my little rock star." "Eskimo kisses." "Okay,bye.Bye." ""Watching the sunsetalways made zoomer "a little sad," ""because that meant bedtime and all the day's funwas done." "" "But every nightwhen the lights went off," ""jewel whispered to him,'tomorrow isa brandnew day." "'" "And it was." "" Well,they thinkyou still got it." "Oh,well,some daysI have the mo,some days I have the jo." "And some


had obtained a 1905 map exercise of the German general staff, in which German troops had gone no further north than Namur and assumed that plans to besiege Belgian forts were a defensive measure against the Belgian army.

A German attack from south-eastern Belgium towards Mézières and a possible offensive from Lorraine towards Verdun, Nancy and St. Dié was anticipated; the plan was a development of Plan XVI and made more provision for the possibility of a German offensive through Belgium. The First, Second and Third armies were to concentrate between Épinal and Verdun opposite Alsace and Lorraine, the Fifth Army was to assemble from Montmédy to Sedan and Mézières and the Fourth Army was to be held back west of Verdun, ready to move east to attack thethe XIII Corps attacked Cirey and was engaged by artillery and machine-guns, which repulsed the French with many casualties. On 15 August, the Second Army reported that German long-range artillery had been able to bombard the French artillery and infantry undisturbed and that dug-in German infantry had inflicted many casualties on the French as they attacked.

The Second Army had to attack methodically after artillery preparation but managed to push back the Germans. Intelligence reports identified a main line of resistance of the German 6th Army and 7th Army (combined under Crown Prince Rupprecht of Bavaria) close to the advanced French troops and that a counter-offensive was imminent. On 16 August, the Germans opposed the advance with long-range artillery-fire and on 17 August, the First Army reinforced the advance


increased expression of adhesion molecules (maximum increase for intracellular adhesion molecule (ICAM): 1.76 +/- 0.26-fold; vascular cell adhesion molecule (VCAM): 1.65 +/- 0.25-fold; E-selectin: 2.86 +/- 0.57-fold). However, BFAECs were hyporesponsive to lipopolysaccharide (LPS) (range, 0.25-20 microg/mL) in adhesion molecule expression, whereas 1 microg/mL LPS induced 2.14- to 3.71-fold increases in human endothelial cells. The differential responses to LPS were not related to TLR-2 and toll-like receptor (TLR)-4 expression on the cell surface. And baboon microvascular endothelial cells had similar features as BFAECs. We observed constitutive expression of interleukin (IL)-6, IL-8, granulocyte macrophage colony-stimulating factor (GM-CSF), and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells, and these cytokines were further induced by TNF-alpha and LPS. We also demonstrated that the responses to TNF-alpha or LPSwhere you have access to." : "Všetky ankety, ku ktorým máte prístup.",
    "Toggle Sidebar" : "Prepnúť bočný panel",
    "Deleted" : "Zmazané",
    "There are no vote options, add some in the options section of the right sidebar." : "Nie sú tu žiadne možnosti voľby, pridajte nejaké v časti Voľby na pravej bočnej lište.",
    "There are no vote options. Maybe the owner did not provide some until now." : "Nie sú tu žiadne možnosti voľby. Možno ich doteraz majiteľ neposkytol.",
    "Switch to mobile view" : "Prepnúť na zobrazenie pre mobilné zariadenia",
    "Switch to desktop view" : "Prepnúť na zobrazenie pre počítače",
    "Date order" : "Dátum objednávky",


#if __cplusplus
#   include <complex>
typedef std::complex< double > cplx;
#else
#   include <complex.h>
#if defined(__GNUC__) || defined(__GNUG__)
typedef double complex cplx;
#elif defined(_MSC_VER)
typedef _Dcomplex cplx;
#endif
#endif

#include <math.h>
#include <stdio.h>
#include <string.h>
#include <stdlib.h>

#include "stats.h"
#include "fft.h"
#include "histcounts.h"

#include "helper_functions.h"

#ifndef CMPLX
#define CMPLX(x, y) ((cplx)((double)(x) + _Imaginary_I * (double)(y)))
#endif
#define pow2(x) (1 << x)

int nextpow2(int n)
{
    n--;
    n |= n >> 1;
    n |= n >> 2;
    n |= n >> 4;
    n |= n >> 8;
    n |= n >> 16;
    n++;
    return n;
}

/*
static void apply_conj(cplx a[], int size, int normalize)
{
    switch(normalize) {
        case(1):
         fft(F, nFFT, tw);
    cplx divisor = F[0];
    for (int i = 0; i < nFFT; i++) {
        F[i] = _Cdivcc(F[i], divisor); // F[i] / divisor;
    }

    double * out = malloc(nFFT * 2 * sizeof(out));
    for (int i = 0; i < nFFT; i++) {
        out[i] = creal(F[i]);
    }
    free(F);
    free(tw);
    return out;
}

int co_firstzero(const double y[], const int size, const int maxtau)
{

    //double * autocorrs = malloc(size * sizeof * autocorrs);


 {
            return NAN;
        }
    }

    //const int tau = 2;
    //const int numBins = 5;

    double * y1 = malloc((size-tau) * sizeof(double));
    double * y2 = malloc((size-tau) * sizeof(double));

    for(int i = 0; i < size-tau; i++){
        y1[i] = y[i];
        y2[i] = y[i+tau];
    }

    // set bin edges
    const double maxValue =max_(y, size);
    const double minValue = min_(y, size);

    double binStep = (maxValue - minValue + 0.2)/5;
    //double binEdges[numBins+1] = {0};
	double binEdges[5+1] = {0};
    for(int i = 0; i < numBins+1; i++){
        binEdges[i] = minValue + binStep*i - 0.1;
        // printf("binEdges[%i] = %1.3f\n", i, binEdges[i]);
    }

    // count histogram bin contents
    int * bins1;
    bins1 = histbinassign(y1, size-tau, binEdges, numBins+1);

    int * bins2;
    bins2 = histbinassign(y2, size-tau, binEdges, numBins+1);


3] = 0;
        } else {
            _curImageData.data[offset + 3] = 255;
        }

    }
  _context.putImageData(_curImageData, 0, 0);
}

And this all works perfectly.  The issue I'm having is when I create a canvas twice the size of my image (or half the size, for that matter) and draw the image to fit the canvas size.
function copyImageToCanvas(aImg)
{
  _canvas = document.getElementById("canvas");
  var w = aImg.naturalWidth * 2;  //double the size!
  var h = aImg.naturalHeight * 2; //double the size!

  _canvas.width = w;
  _canvas.height = h;

  _context = _canvas.getContext("2d");
  _context.clearRect(0, 0, w, h);
  _context.drawImage(aImg, 0,and 1.
5
Suppose 3458 = -11*d + 49*d. Calculate the lowest common multiple of 273 and d.
273
Let f = -1133649/574040 + -2/14351. Calculate the common denominator of f and 8/5.
40
Let f = 14 + 15. Suppose p - 3*u = 15, 3*p - u - f = -0*u. Find the common denominator of (-6)/(-36) - 21/p and 81/14.
42
Let g(d) = 5*d**2 + 1. Let j(c) = -3*c**2 - 22*c - 5. Calculate the least common multiple of j(-7) and g(-1).
6
Let g be ((-112)/(-10))/((-2)/30). Let y be 52137/g*39/18. Let h = 4737/7 + y. Find the common denominator of 37/10 and h.
80
Suppose 0 = -6*i + 2*i - q - 25, 4*i = -3*q - 35. Let w = i - -35. What is the smallest common multiple of w


- a) + 62/36 and c.
90
Let g(r) = r**3 - 6*r**2 - 10*r - 36. Calculate the least common multiple of g(8) and 42.
84
Calculate the common denominator of 5/((-4200)/418) + 6/24 and -8/63.
315
Suppose -2*w + f - 6 = 8, 2*w + 8 = -2*f. Calculate the common denominator of (-42)/(-8) + w + 182/96 and -1/3.
48
Let n = 2396 + -9633/4. What is the common denominator of 29/7 and n?
28
Let z = -160 + 148. Let u(g) = 7 + 12*g - 2*g**3 + 13*g**2 - 2*g**3 + 5*g**3. What is the lowest common multiple of u(z) and 6?
42
Let j = 8636 - 129482/15. Find the common denominator of j and (-6)/10*((-1615)/(-150))/(-19).
150
Let s(u) = -4*u - 21. Let v be s(-7). Suppose 2*j + 9 = 3*b968. Find the common denominator of k and 3 + (5985/(-12))/19.
36
Suppose -13*x = -49*x + 1152. What is the lowest common multiple of 24 and x?
96
Let l = 38 - 35. What is the common denominator of 17/4*(l + -2) and 43/10?
20
Suppose -4*u + 42 = -6*u. Find the common denominator of ((-2)/(-32) + 0)/(u - -22) and -11/4.
16
Let x = 279495 + -571939/2. Let t = 97208/15 + x. Calculate the common den


The authors confirm that all data underlying the findings are fully available without restriction. All data are included within the manuscript.

Introduction {#s1}
============

The *telomerase reverse transcriptase* (*TERT*) gene encodes the catalytic subunit of telomerase, which is normally not expressed by postmitotic somatic cells. Telomere deficiency has been linked to cellular aging and cancer, while upregulation of human *TERT* gene expression has been associated with the acquisition of stem cell-like properties, including immortalization [@pone.0100297-Papadopoulos1]. Mutations in the *TERT* promoter that create a novel binding site for T-cell factor (TCF) transcription factors, thereby increasing *TERT* gene transcription, have been identified in cutaneous melanoma. Individuals with these mutations have increased cancer susceptibility, as demonstrated in studies of familial melanoma [@pone.0100297-Horn1], [@pone.0100297-Huang1]. TCF transcription factors have important roles in developing and adult brainsreagent Kit with gDNA Eraser (TaKaRa Bio Inc.) in a 20 µl reaction volume. The qRT-PCR reaction volume of 20 µl contained 0.5 µl each of primers hTERT-qRT-F (5′-ACT GGC TGA TGA GTG TGT ACG TCG T-3′) and hTERT-qRT-R (5′-ACC CTC TTC AAG TGC TGT CTG ATT CC-3′) (10µM), 10 µl SYBR Premix Ex Taq (TaKaRa Bio, Inc.), and 4 µl cDNA, with four replicates per sample. Reactions were performed on a Rotor-Gene 6000 real-time rotary analyzer (Corbett Life Science, Sydney, Australia) at 95°C for 10 min, followed by 40 cycles of 95°C for 10 s, 60°C for 15 s, and 72°C for 20 s. *TERT* mRNA levels were normalized to a glyceraldehyde-3-phosphate dehydrogenase fragment. Relative expression level was determined using the comparative ΔΔCT method with a calibration


or cultured under hypoxic conditions through CoCl~2~ treatment or exposure to 1% O~2~. WT, wild-type; 124T, −124 C\>T mutation; 146T, −146 C\>T mutation. (A) Compared to wild-type, 124T and 146T displayed significantly higher *TERT* promoter activity in the presence of TMZ. No significant difference was observed between the DMSO (control) and TMZ (50 µM) treatment groups. (B) Compared to wild-type, 124T and 146T displayed significantly higher *TERT* promoter activity under hypoxic conditions. No significant difference was observed between control and CoCl~2~ treatment groups (B); similar results were observed when hypoxia was induced by exposure to 1% O~2~ (C). The means of four measurements per experimental group are shown; error bars indicate standard deviation. \**P*\<0.05; \*\**P*\<0.01.](pone.0100297.g003){#pone-0100297-g003}

Discussion {#s4}
==========

Glioblastoma is the most common type of primary brain tumor, yet the prognosisprognostic biomarkers for glioblastoma is critically important. Such markers could also be used to screen for individuals who are at a higher risk for tumor recurrence, so that treatment approaches can be tailored to each patient, thereby potentially sparing patients from some of the inevitable complications that accompany the current forms of therapy.

The results of the present study demonstrate that mutations in the *TERT* gene promoter are associated with decreased survival in glioma patients ([Fig. 2](#pone-0100297-g002){ref-type="fig"} and [Table 2](#pone-0100297-t002){ref-type="table"}). The role of telomerase in tumorigenesis is well-established in many types of cancer, and high telomerase activity is linked to high tumor malignancy [@pone.0100297-Shay1] and chemo-resistence [@pone.0100297-Guo1], [@pone.0100297-Ueda1], [@pone.0100297-Wang1]. The activation of telomerase is tightly regulated at the transcriptional level, with several studies indicating that *TERT* transcription is the


Neville Ramsbottom-Isherwood

Wing Commander Henry Neville Gynes Ramsbottom-Isherwood   (13 July 1905 –  24 April 1950) was a New Zealand born Royal Air Force test pilot and commanding officer during the Second World War and the post-war period. He was one of only four wartime British Commonwealth recipients of the Order of Lenin, after he had led an RAF fighter wing to help defend northern Russia and introduce British aircraft to Soviet Air Force personnel. He was killed in a flying accident in 1950.

Early career
Born on 13 July 1905 at Petone near Wellington in New Zealand, he was the son of Henry Lionel Ramsbottom-Isherwood and Lilian Catherine née Kelly. He was educated at St Patrick's College and St Joseph's College, Geelong, Sydney. Commissioned into the New Zealand /// <param name="value">参数或结果</param>
        /// <returns></returns>
        Boolean Decode(IMessage msg, out String action, out Int32 code, out Packet value);

        ///// 编码 请求/响应
        ///// <param name="action">服务动作</param>
        ///// <param name="code">错误码</param>
        ///// <param name="value">参数或结果</param>
        ///// <returns></returns>
        //Packet Encode(String action, Int32 code, Object value);

        /// 解码参数
        /// <param name="action">动作</param>
        /// <param name="data">数据</param>


when it was completed – it seemed the heyday of Postmodernism had passed. Critic Edwin Heathcote wrote that at the point of completion: "Postmodernism, the architectural style [No 1 Poultry] so perfectly represents and which reached its apogee in the 1980s, had slipped unceremoniously out of fashion."

Characteristically, Prince Charles described No 1 Poultry derisively as a "1930s wireless", while architecture critic Hugh Pearman compared the building to a hen. "Lots of people still cluck over Jim's fat hen at No 1 Poultry," he wrote. "I suspect this is because, deep down, they don't really like the idea of a modern building with the eccentric character of an earlier age. It is not pretty. It is not graceful. It does not integrate itself. It is definitely strange. But itinclude open shopping colonnades on the Poultry and Queen Victoria Street facades, an open light-filled courtyard, a rooftop garden, and even access to the underground station below.

"[No 1 Poultry's] success comes from its accessibility, legibility and immense character – many thousands of people walk through the heart of the building every day glimpsing up to the sky or following the rain drops down to the concourse level some take the lifts which pop out like a cork from a champagne bottle in the middle of the oasis that is the public roof garden and enjoy the views right across the City," said Bain.

At the beginning of this month, Stirling's widow called on the City of London planners to reject the scheme in UK architecture magazine the Architect's Journal.

Zaha


during some batch database operations.
I am happy that I can still retain the same level of control on transactions and transaction isolation level by "Enlist" (another Microsoft new word, why do not they just use "use") my managing my own connection and "TransactionScope" where I can choose my desired isolation level.
Now, my question about the "ObjectContext.AcceptAllChanges" are:

Who is making the changes?
Who is accepting the changes?

Thanks ......

A:

By default AcceptAllChanges is called during SaveChanges. If saving succeeds changes are accepted. You can turn this off and accept changes manually by calling AcceptAllChanges. This can be useful in some more advanced scenarios. One of such scenarios can be complex transaction where multiple transactional resources are handled.
For example let's assume that I want to save data to database and send message toComputer simulation of T3/T7 phage infection using lag times.
A minimal mechanism is proposed which describes the transcriptional and translational processes for four phage proteins (RNA polymerase, DNase, primase and DNA polymerase) involved in T3/T7 DNA replication. Phage DNA replication is also included. It is shown how lag times may be incorporated into a kinetic mechanism. The distinct three-stage transport of phage DNA into the bacterial host (E. coli) is considered. DNA transport is assumed to be rate-determining for the transcription of class I and II proteins. Transcriptional and translational lag times have been calculated on the basis of available gene mapping of T7 phages. The kinetic behavior of T7 and T3 phage infection is practically identical. The hydrolysis of bacterial DNA by phage DNase (endonculease and exonuclease) as


The 'Va Va Voom' rapper and 'My All' singer Mariah were filmed getting into a heated dispute back in October last year, amid reports Mariah didn't want the US star on the panel, but Nicki says she is now over the pair's fall out.

"We're fine. I cannot hold a grudge against Mariah Carey," Nicki told Ellen DeGeneres on The Ellen Show this week. "I don't know if she's gotten over it but I have.

"I mean, I'm over there cracking up, laughing, having fun and if she's still holding a grudge, I don't know, like I don't care," Nicki explained. "[But] I'm not looking forward to the live shows."

The 'Starships' singer went on to admit she is worried about saying something "crazy" if Mariah makes any comments directed towardsbelow (Credit: Twitter):

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/*
 * Licensed to the Apache Software Foundation (ASF) under one
 * or more contributor license agreements.  See the NOTICE file
 * distributed with this work for additional information
 * regarding copyright ownership.  The ASF licenses this file
 * to you under the Apache License, Version 2.0 (the
 * "License"); you may not use this file except in compliance
 * with the License.  You may obtain a copy of the License at
 *
 *   http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing,
 * software distributed under the License is distributed on an
 * "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
 * KIND, either express or implied.  See the License for the
 * specific language governingfragmented. JAVA-based technologies such as J2ME have been stymied with high hurdles to application qualification and numerous manufacturer-specific additions. MICROSOFT.NET technology, while promising, has been slow to grow on non-Intel platforms. Binary-based solutions like SYMBIANOS and BREW have failed to develop traction in a cautious market. Competing standards and interests in the industry among carriers, device manufactures, technology vendors, operating system vendors and application developer continue to plague the industry.
Several significant hurdles obstruct easy development of rich, widely deployable applications that run (at least partially) natively on a device:
Multiple platforms require porting code to a variety of different API standards. Even within a single architecture specification, different platforms have slight variations that require extensive testing and modification.
Competing languages (primarily C and JAVA) have no easy porting relationship.
Service operators


program must resume, it must obtain information to resurrect its internal data structures in their previous state by decomposing the bundle of data it previously wrote. Variations on this model include placing data into a database, serial memory ring or other external structure. This strategy has the advantage that the state of the program could be resumed on a different platform or computer system than the original, however the application must take excessive care to ensure that every piece of data has been saved in an identifiable format.
It must save its existing buffer of memory, exactly as it was left, into a single large snapshot, disentangle any memory references maintained by the operating system and write the complete state of the processor to disk. A variation on thisa voltage in the region greater than the low potential VL but less than the high potential VH, in addition to the output line 105i. After the selected bit line 104i is precharged, the voltage of the corresponding word line 103i related to the read target memory cell is set to the xe2x80x9cHxe2x80x9d level, and the transistor 102i whose gate is connected to the thus selected word line 103 is set to ON. Concerning the read target memory cell, in the case where the drain of the ON-set transistor 102i is connected to the corresponding bit line 104i (namely the case of either one of the transistors 1021, 1023, 1024, 1025 and 1026), the precharged potential flows into the ground to thereby lower the potential of the corresponding


is generally attributable to the losses associated with operating the switching regulator circuit 100. For example, during the time the power MOSFET switch 101 is OFF, the current through inductor 115 always ramps down by the same amount regardless of the output current of the switching regulator circuit 100. At low output currents this can cause the current in inductor 115 to reverse polarity and, thus, pull power from the load 103. During the following ON cycle, this current again ramps positive such that the average inductor current equals the load current. Losses associated with this constant ripple current, along with switching losses due to the charging and discharging of the gate of power MOSFET switch 101, quiescent current losses in the control circuitry of the switching regulatorcircuit 100, switch driver current losses and inductor/transformer winding and core losses, can produce large reductions in efficiency at low output currents. The reduction in efficiency of the switching regulator circuit 100 at low output current can become important in battery-operated systems where maximizing battery lifetime is desirable.
A third disadvantage of switching regulator circuit 100 is that it can be damaged under extreme operating conditions. In particular, the power switch 101 can be damaged. Such conditions occur primarily in the event of short-circuits at the output and when turning the switching regulator circuit 100 ON.
A fourth disadvantage of the conventional switching regulator circuit 100 is that power MOSFET switch 101 must be very large so that when the switch is open, the resistance is close to zero (no


into a state of operation where both power MOSFETs 211, 213 are simultaneously OFF under conditions where the output voltage VOUT can be maintained substantially at a regulated voltage by output capacitor 217. The ability of push-pull switch 201 to go into such a "sleep mode" is in contrast to other conventional regulator circuits where one of the two power MOSFETs 211, 213 is substantially ON at all times.
When the output voltage falls below the regulated voltage in such a mode, control circuit 207 is adapted to briefly turn push-pull switch 201 on to recharge the output capacitor 217 back to a voltage level in excess of the regulated voltage.
Although the "sleep mode" feature of conventional switching circuit reduces the regulator circuit power consumption since push-pull switch 201
293 B.R. 334 (2003)
In re PREMIER OPERATIONS, Debtor-in-Possession.
NOVA Information Systems, Inc., Appellant,
v.
Premier Operations, Ltd., Debtor-in-Possession, Appellee.
No. 02 Civ. 6997(VM).
United States District Court, S.D. New York.
March 26, 2003.
*335 Toni Marie McPhillips, Duane Morris LLP, New York City, for appellant.
Ken Coleman, Allen & Overy, New York City, for appellee.

DECISION AND ORDER
MARRERO, District Judge.
Appellee Premier Operations, Ltd. ("Premier") filed an emergency motion (the "Motion") with this Court pursuant to Rules 8011 and 8019 of the Federal Rules of Bankruptcy Procedure (the "Bankruptcy Rules"), seeking an expedited determination of appellant NOVA Information System Inc.'s ("NOVA") appeal (the "Appeal") from a July 21, 2002 order (the "Reclassification Order") of the Bankruptcy Court (the "Bankruptcy Court"), which sustained an objection by Premier to NOVA's amended proof of claim (the "Amended Claim"). The Reclassification Order


is contingent upon the final resolution of NOVA's Amended Claim. Thus, further delay in resolving the status *336 of NOVA's Amended Claim will result in further delay in executing the Plan.
Second, Premier asserts that a settlement (the "Settlement") among Premier, the Official Committee of Unsecured Creditors (the "Committee") and Premier's single largest secured creditor, DLJ Capital Funding, Inc. ("DLJ") is in jeopardy of unraveling if NOVA's status is not quickly resolved because the Settlement is dependent on the Plan being confirmed. Specifically, Premier alleges that the Settlement provides for the conclusion of arrest proceedings and sale of Premier's remaining ship, and that further delay of this sale shall result in further depreciation of the ship and consequently a smaller amount of funds with which to pay Premier's creditors.
BasedLicht, director of the UC Berkeley Botanical Gardens, said that the political controversy surrounding the artwork is missing the point.

“It’s really just a piece of art, and the point is to create art that fits into nature,” he said. “What we’ve basically done is recycle these materials.”