the T cell response. Sampling the pool of intratumoral CD8 T cells by biopsy and characterizing them for TCR gene usage or specificity will provide a snapshot that is necessarily incomplete with respect to the past and future of the antitumor immune response.

The heterogeneous distribution of CD8 T cells may result from physical barriers, the presence of myeloid-derived suppressor cells releasing repulsive cues ([@bib20]; [@bib24]), the failure of infiltrating CD8 T cells to respond to chemo-attractive signals, hypoxia and hypoxic signaling ([@bib22]), necrosis or some combination of these factors. We conclude that the ability to image an entire tumor environment noninvasively, making it possible to distinguish between the different distribution patterns of CD8 T cells, may serve as a valuable prognostic indicator of the success of checkpoint blockade1003.49, found 1003.70.

Synthesis of (Gly)~3~-DFO-azide {#s15}
-------------------------------

The peptide GGG-PEG3-Cys-PEG3-Lys(azide) was synthesized by standard solid-phase peptide synthesis and was dissolved in 20 mM NaHCO~3~ buffer, pH 8.3. Maleimide-DFO was dissolved in DMSO. The peptide was added to the DFO solution and left to stir at room temperature for 30 min until LC-MS analysis indicated near-complete conversion to the product. The solution was filtered and purified by reverse phase-HPLC with a semi-preparative column (C~18~ column, Gemini, 5 µm, 10 × 250 mm; Phenomenex) at a flow rate of 5.0 ml/min; solvent A: 0.1% TFA in H~2~O, solvent B: 0.1% TFA in CH~3~CN. (G)~3~-DFO-azide eluted at 60--65% solvent B. Fractions containing pure product were collected and lyophilized. LC-MS calculated for C~65~H~115~N~18~O~24~S \[M+H\]^+^ 1,563.80, found 1,563.77.

Preparing ^89^Zr-labeled VHHs {#s16}
-----------------------------

The radiolabeling was performed following


watch at airports and around sensitive locations. Instead, the memo says that Bush can order the military to conduct “raids on terrorist cells” inside the US, and even to seize property. “The law has recognized that force (including deadly force) may be legitimately used in self-defense,” they write. In 2009, Reuters will write, “The US military could have kicked in doors to raid a suspected terrorist cell in the United States without a warrant” under the findings of the OLC memo. “We do not think that a military commander carrying out a raid on a terrorist cell would be required to demonstrate probable cause or to obtain a warrant,” Yoo and Delahunty write. [US Department of Justice, 10/23/2001 ; New York Times, 3/2/2009; Reuters, 3/2/2009] The memo reasonsremainder of the cost for a new awning.

The women have been co-housing since the summer. They share kitchen duties, as well as the bills and other responsibilities of the house. (Craig Chivers/CBC)

But co-housing goes beyond practical financial arrangements, said Shnall. "It's cheaper to live with somebody else but it's also better for our physical health and for our mental health."

Back in the kitchen, with the chicken stew almost done, the London roomies know living together will mean eating better and healthier. As for companionship, there's always someone around for a walk, a talk or just a simple hello.

"I walk up the stairs, and my friends are here having their breakfast. Good morning, Phyllis. How are you?"said Brady.

When asked if there are any regrets, it's a quick and unanimous,


game to come out so I can set up my own experiments and collect more data. Really, the best test for the gravitational force would be to get the bird to orbit the moon. That would be cool.

What Is the Moon Made Of? ————————-

Let me go with my lowest calculation for the mass of the moon. Remember, this mass is based on the assumption that this is a real moon with real gravity. Double remember that I really haven't confirmed that it is real-ish gravity. So, I will start with a mass of 7.8 x 1012 kg. With this, I can find the density of the moon. Assuming a radius of 6.3 meters, this would be a density of 7.4 x 109 kg/m3.

Compare this to the density ofNews » DEA Raid of Legal California Dispensary Caught on Camera

Despite the Obama Administration’s claims that they would not interfere with medical marijuana growers, caregivers and dispensaries as long as they were in compliance with state laws, the DEA raids have only increased.

When Matt Cohen assumed he was protected by making sure that his medical marijuana business, Northstone Organics, worked closely with local law enforcement. That didn’t stop heavily armed Drug Enforcement Administration agents from raiding him on October 13 – all caught on tape by his high tech security system.

[source California Watch]

Tags: CA, DEA, dispensary, Matt Cohen, Northstone Organics, raid


The parameters of the model are the ones appearing in @1995ApJ...451..598J.

The initial satellites are modeled as Plummer spheres with $10^6$ particles, plummer radius of 0.3 kpc and cuttof radius of 1.5 kpc. Their initial masses are $10^7$ and $10^8$ M$_{\odot}$ respectively, and intrinsically dark matter free. For the construction of the spheres the algorithm proposed by has been used.

Satellite Evolution
===================

Satellites in very eccentric orbits are completely depopulated in a very short time interval, usually in a single perigalactic passage. On the other hand, satellites on orbits with very low eccentricity can retain more than 90% of their initial mass over a Hubble time. These kind of orbits lead to an object that does not reach an out-of-equibrium state. The intermediate case corresponds to satellites that loose more than90% of their initial mass but retain more than 1% of the mass for about 1 Gyr or more (see Figure \[fig:lagrange-radii\]). These satellites present an out-of-equilibrium phase and are the objects we are more interested in.

![Lagrange radii containing (bottom to top) 1%, 10%, 20%, ... , 90% of the initial mass of a satellite with $10^7$ [M$_\odot$]{}. Bottom panel: galactocentric distance of the density maximum. The parameters of the orbit are given in the upper right corner[]{data-label="fig:lagrange-radii"}](figure1.eps){width="\linewidth"}

Mass-to-light ratios
====================

In Figure \[fig:m2l\] we plot the evolution of the M/L ratio for two out-of-equilibrium satellites obtained using the core fitting formula [@1986AJ.....92...72R and references therein]. The M/L ratio remains relatively constant as the satellite is being smoothly depopulated. After the satellite enters the disrupted phase the M/L ratio rises considerably,


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.
Do be very careful with the property appearance. In Chrome25+ (possibly earlier) that makes the inputs in question non-displayed. And Firefox shows illogical behavior, in my opinion. Which generally is not a good sign.
Lastly, you should now add the tag javascript to your question, plus the tag form. And you should correct it: there is no elemtent[type="radio"], not even an element[type="radio"]. In the Fiddle you have the right code, but your question doesn't look very smart the way it is now.

Setting up a new Tribon project for the outfitting applications involves the creation of new outfitting modules. Boring job that has to be done. The usual way is to use "Tribon design manager" - an interactive application where the outfitting modules can be created one by one. Imagine that the number of these modules is 50 or 100 or more?

Here is one simple Vitesse script, that will help you create all outfitting modules at once. It uses an external text file for input.

This project originaly was created for demonstration purposes at the very beginning of Vitesse, just when it was implemented for Tribon structure functionality. At that time there was no idea to make it open source project, neither to update it further because we expected that Tribon


elite athletes in similar circumstances. (Take Alberto Contador’s clenbuterol case, for example.)

Grove is free to race again, to chase more records. But, at 90, where does he go from here?

***

“He’s absolutely crushed,” Cusick says of Grove’s current state.

Cusick says when Grove first found out about the positive test, about the tainted meat and the contaminated supplements, he felt terrible. “Tim, did this help me?” Grove asked Cusick.

“He was afraid he cheated,” Cusick says.

Grove had no interest in fighting the sanction, says Cusick, “Because he wanted to make a good example, that if you make a mistake, you have to own it.”

Cusick says he had warned Grove multiple times against taking supplements, which he says Grove took not for athletic reasons, but because he was fearful of losing hisin other studies \[[@B43],[@B44]\], we use garden biomass as an indirect fitness indicator for the ant in the ant-cheating experiment.

Prisoner\'s Dilemma computer simulation
---------------------------------------

Using the classic Prisoner\'s Dilemma model (PD) \[[@B34]\], we further explore our empirical results that indicate parasites can play a role in stabilizing cooperation. In the PD two players interact, each has the ability to cooperate or cheat. Cooperation provides the opponent a benefit (*b*), while incurring a cost (*c*) to the player (b \> c \> 0). The highest payoff is received when a player cheats while its partner cooperates: the cheater benefits without paying the cost of cooperation (*T*emptation to cheat *T*= *b*). If both players cooperate each receives a net benefit (*R*eward) of *R*= *b*- *c*, while mutual cheating results in a *P*unishment


fungi, in opposition to the garden parasite, is further illustrated by the contribution the ants make to cultivar defense. Specifically, the ants employ specialized behaviors to physically remove parasitic inoculum from the fungus garden \[[@B44]\]. Without ant behavioral defenses, the garden is rapidly overgrown by the parasite \[[@B15]\], indicating that defense against *Escovopsis*requires cooperation between ants and their fungal mutualists. The early origin of *Escovopsis*within the symbiosis and its coevolutionary history with the ants and their fungal cultivar \[[@B31]\], suggests that the parasite may have been a stabilizing force within the ant-fungal mutualism for millions of years.

Our view of the stability of cooperation has largely developed out of game theory, especially the PD model \[[@B34]\]. In the classic single interaction model, cheating is always favored over cooperation (*T*\>is present from birth.

Apart from treatment of the complications (such as pain relief and joint replacement for the cartilage damage), the drug nitisinone has been found to suppress homogentisic acid production, and research is ongoing as to whether it can improve symptoms. Alkaptonuria is a rare disease; it occurs in one in 250,000 people, but is more common in Slovakia and the Dominican Republic.

Signs and symptoms

Patients with black bone disease are asymptomatic as children or young adults, but their urine may turn brown or even inky black if collected and left exposed to open air. Pigmentation may be noted in the cartilage of the ear and other cartilage, and the sclera and corneal limbus of the eye.

After the age of 30, people begin to develop pain in the


blastula, staining is restricted to a few cells at the posterior pole where gastrulation will start. However, once gastrulation starts, the Cnox4-Pc signal disappears and is absent in later stages of larval development. Phylogenetic analysis shows that not all cnidarian Hox-like genes have recognizable orthologues in bilaterian groups. However, the expression analysis of Cnox1-Pc and Gsx correlates to some extent with the expression pattern of cognate genes of bilaterians, confirming the conservation of genes involved in organizing animal body plans and their putative common ancestral origin.Impaired cortical network for preattentive detection of change in speech sounds in schizophrenia: a high-resolution event-related potential study.
Schizophrenia is associated with language-related dysfunction. At the most basic level, the dysfunction of schizophrenic patients in perceiving phoneme boundaries has been demonstrated in a behavioral task. The goal in this study was to obtain an electrophysiological index of preattentive detection of change in speech sounds by schizophrenic patients. A high-density recording system was used to measure mismatch negativity, i.e., difference in electrophysiological responses between standard and deviant auditory stimuli. The amplitude of mismatch negativity was measured in 23 right-handed schizophrenic patients and in 28 healthy comparison subjects. Three types of mismatch negativity were recorded: change in duration of pure-tone stimuli, change in duration of the Japanese vowel /a/, and difference


pre-existing conditions. These bills annoy more moderate GOP members (Collins) and also more conservative members (the House Freedom Caucus and Paul) by trying to split the difference between divergent views of health care. The goals (keep the good parts of Obamacare while repealing Obamacare) also fall apart under scrutiny from policy analysts like the Congressional Budget Office, creating some incentive for rushed, opaque processes that annoy more institutionalist Republicans (McCain, Murkowski).

Obviously, this option goes away if Democrats win control of the House or Senate in 2018 or if Republicans no longer occupy the Oval Office.

Executive branch undermines Obamacare: Millions of Americans are already buying insurance through Obamacare exchanges or living in states that have expanded Medicaid. Cutting off the advertising budget for Obamacare is most likely to affectGlasgow School of Arts’ Degree show as the best Art show to visit in Scotland.

The Times said: "This is the best opportunity to discover artists before their reputations and prices soar the Independent described the event as ‘one of the 'best degree shows' outside of London."

Vegetarian since the age of 14 and a Vegan for the last 5 years Zoe decided to explore the issues of intensively farmed animals related to her own femininity. The life of the modern dairy cow, kept perpetually pregnant and thus full of hormones whilst suffering the emotional stress of loss of her baby calf inspired Zoe to focus on these psychological and physiological issues and the ethical alternatives.

Zoe has cast her own body weight of delicious dairy free vegan chocolate, donated by


of 81494?
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var undefined = (void 0); // Paranoia

// Beyond this value, index getters/setters (i.e. array[0], array[1]) are so slow to
// create, and consume so much memory, that the browser appears frozen.
var MAX_ARRAY_LENGTH = 1e5;

// Approximations of internal ECMAScript conversion functions
var ECMAScript = (function() {
  // Stash a copy in case other scripts modify these
  var opts = Object.prototype.toString,
      ophop = Object.prototype.hasOwnProperty;

  return {
    // Class returns internal [[Class]] property, used to avoid cross-frame instanceof issues:
    Class: function(v) { return opts.call(v).replace(/^\[object *|\]$/g, ''); },
    HasProperty: function(o, p) { return p in o; },
    HasOwnProperty: function(o, p) { return ophop.call(o, p); },
    IsCallable: function(o) { return typeof ovar Float64Array = makeConstructor(8, packF64, unpackF64);

  exports.Int8Array = exports.Int8Array || Int8Array;
  exports.Uint8Array = exports.Uint8Array || Uint8Array;
  exports.Uint8ClampedArray = exports.Uint8ClampedArray || Uint8ClampedArray;
  exports.Int16Array = exports.Int16Array || Int16Array;
  exports.Uint16Array = exports.Uint16Array || Uint16Array;
  exports.Int32Array = exports.Int32Array || Int32Array;
  exports.Uint32Array = exports.Uint32Array || Uint32Array;
  exports.Float32Array = exports.Float32Array || Float32Array;
  exports.Float64Array = exports.Float64Array || Float64Array;
}());

//
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 Ross, Assistant Attorney
General, Tallahassee, for Appellee.

PER CURIAM.

      Leeto L. Allen appeals from the final order of the lower court denying his

motions for postconviction relief. Those motions and Allen’s petition for writ of

habeas corpus—which the lower court converted to a motion for postconviction

relief—all raised the same arguments: Allen’s convictions and sentences should be
vacated because the presiding trial court judge did not conduct an evidentiary

hearing on his competency following the issuance of an October 5, 2010,

competency evaluation finding him competent to proceed to trial, and did not enter

an order expressly finding him competent to proceed. Important to our assessment

of Allen’s contentions, Allen did not file a direct appeal.

       The lower court was correct in denying Allen relief. “The competency


2]
17/07/07 13:51:41 INFO TaskSchedulerImpl: Removed TaskSet 63.0, whose tasks have all completed, from pool
17/07/07 13:51:41 INFO TaskSetManager: Lost task 2.0 in stage 63.0 (TID 746) on executor localhost: org.apache.spark.api.python.PythonException (Traceback (most recent call last):
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/worker.py", line 111, in main
    process()
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/worker.py", line 106, in process
    serializer.dump_stream(func(split_index, iterator), outfile)
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/serializers.py", line 263, in dump_stream
    vs = list(itertools.islice(iterator, batch))
  File "<stdin>", line 1, in <lambda>
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/sql/types.py", line 1272, in __getattr__
    raise AttributeError(item)
AttributeError: lower
) [duplicate 3]
17/07/07 13:51:41 INFO TaskSchedulerImpl: Removed TaskSet 63.0, whose tasks have all completed, from pool
17/07/07 13:51:41 INFO TaskSchedulerImpl: Cancelling stage 63
17/07/07 13:51:41 INFO DAGScheduler: ResultStage 63 (collect at <stdin>:1) failed in 0.114 s
17/07/07 13:51:41at py4j.Gateway.invoke(Gateway.java:259)
    at py4j.commands.AbstractCommand.invokeMethod(AbstractCommand.java:133)
    at py4j.commands.CallCommand.execute(CallCommand.java:79)
    at py4j.GatewayConnection.run(GatewayConnection.java:209)
    at java.lang.Thread.run(Thread.java:745)
Caused by: org.apache.spark.api.python.PythonException: Traceback (most recent call last):
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/worker.py", line 111, in main
    process()
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/worker.py", line 106, in process
    serializer.dump_stream(func(split_index, iterator), outfile)
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/serializers.py", line 263, in dump_stream
    vs = list(itertools.islice(iterator, batch))
  File "<stdin>", line 1, in <lambda>
  File "/usr/local/spark/python/lib/pyspark.zip/pyspark/sql/types.py", line 1272, in __getattr__
    raise AttributeError(item)
AttributeError: lower

    at org.apache.spark.api.python.PythonRunner$$anon$1.read(PythonRDD.scala:166)
    at org.apache.spark.api.python.PythonRunner$$anon$1.<init>(PythonRDD.scala:207)
    at org.apache.spark.api.python.PythonRunner.compute(PythonRDD.scala:125)
    at org.apache.spark.api.python.PythonRDD.compute(PythonRDD.scala:70)
    at org.apache.spark.rdd.RDD.computeOrReadCheckpoint(RDD.scala:306)
    at org.apache.spark.rdd.RDD.iterator(RDD.scala:270)
    at org.apache.spark.scheduler.ResultTask.runTask(ResultTask.scala:66)
    at org.apache.spark.scheduler.Task.run(Task.scala:89)


$\mathbf{v}_{k}^{\text{real}}$ are the INS-indicated linear velocity and the actual linear velocity of *k*th sampling point. Δ*t* is the sampling period of the discrete time system.

Then, the relationship between $d_{k\text{-}1,k}^{\text{INS}}$and $d_{k - 1,k}^{\text{real}}$ is derived:

d

k

\-

1

,

k

real

d

k

\-

1

,

k

INS

=

\|

\|

v

k

\-

1

real

\+

v

k

real

\|

\|

\|

\|

v

k

\-

1

INS

\+

v

k

INS

\|

\|

Where $\mathbf{\text{v}}_{k}^{\text{INS}}$ is described by an equation in the form:

v

k

INS

=

v

k

real

\+

δ

v

k

Here *δ****v***~*k*~ is the INS accumulated velocity error of kth sampling point. Accordingly, (21) is developed into the following form:

d

k

\-

1

,

k

real

d

k

\-

1

,

k

INS

=

\|

\|

v

k

\-

1

INS

\+

v

k

INS

\-

δ

v

k

\-

1

\-

δ

v

k

\|

\|

\|

\|

v

k

\-

1

INS

\+

v

k

INS

\|

\|

Denoting with *N* the number of sampling points on matching sequence, the constraint of scale transform has been derived:

S

=

∑

k

=

2

N

d

k

\-

1

,

k

real

∑

k

=

2

N

d

k

\-

1

,

k

INS

=

∑

k

=

2

N

\|

\|

v

k

\-

1

INS

\+

v

k

INS

\-

δ

v

k

\-

1

\-

δ

v

k

\|

\|

∑

k

=

2

N

\|

\|

v

k

\-

1

INS

\+

v

k

INS

\|

\|

Affine Transformation Based ABC Algorithm {#s4}
=========================================

In order to achieve high positioning accuracy under large initial errors, this paper proposes an affine transformation based ABC algorithm. The proposed algorithm is specifically presented to deal with the gravity matching problem for underwater navigation system. The affine transformation based ABC algorithm introduces     ′
  Simulation time                  16             h

![The INS position error.](fnbot-13-00019-g0001){#F1}

In order to evaluate the algorithm presented in this work, a gravity anomaly base map is required. In the simulations tests, goco05c model (Fecher et al., [@B11]) is used to calculate the gravity anomaly in the area from (147.6°E, 19.5°N) to (156.6°E, 24°N). After interpolated, the grid step is converted to 0.3′. The 3-D map of the gravity anomaly data is shown in [Figure 2](#F2){ref-type="fig"} [(Supplementary Data Sheet 1)](#SM1){ref-type="supplementary-material"}. The gravity anomaly relevant parameters are shown in [Table 2](#T2){ref-type="table"}.

![3-D gravity anomaly base map.](fnbot-13-00019-g0002){#F2}

######

Parameters of gravity


    6.63                     73

Conclusion {#s6}
==========

Gravity aided inertial navigation system can solve the problem of INS error accumulation and ensure the concealment of INS. However, there are still many problems in the field of gravity aided navigation system. In this paper, we focus on the problem of how to ensure the matching accuracy under the large initial errors condition. In order to avoid mismatching under large initial errors, an affine transformation based ABC algorithm is adopted. The simulation results show that the proposed algorithm can achieve high matching precision under the condition of large initial errors.

In addition to ABC algorithm, other evolutionary algorithms can also be usedroute in the Italian Dolomites called “The Fish” sans ropes or safety gear. He once said, “There is only one person you will have to bear for the rest of your life: yourself. That’s why being alone is so difficult. Even in the mountains, and not just because of safety. Being alone strips you naked, it makes you understand who you are, what is your value, the things that matter in life”

David Lama rose to prominence as a teenager with big wins in lead climbing and bouldering competitions. In 2012, he made the first free ascent of the “Compressor Route” on Cerro Torre in Patagonia. Last year, Lama summited Lunag Ri, which until his feat was Himalaya’s highest unclimbed mountain.

Spokane, Washington native Jess Rosskelley was the youngest person


circles), $7.5$–$8.2$ (blue triangles), and $6.5$–$7.5$ (magenta inverted triangles). Results of mass and redshift range with $n_{\rm AGN}<200$ are not plotted because of very large uncertainty. Vertical dotted lines show boundaries of redshift ranges. [*Bottom panel*]{}: $r_0$ against BH mass for the samples of three redshift ranges: $z=0.1$–$0.3$ (red squares), $z=0.3$–$0.6$ (green circles), and $z=0.6$–$1.0$ (blue triangles). []{data-label="redshift"}](z-r-m.eps "fig:"){width="\linewidth"} ![ [*Top panel*]{}: The correlation length ($r_0$) against redshift for the samples of four BH mass ranges: $\log({M_{\rm BH}}/{\, M_\odot})=9.0$–$10.0$ (red squares), $8.2$–$9.0$ (green circles), $7.5$–$8.2$ (blue triangles), and $6.5$–$7.5$ (magenta inverted triangles). Results of mass and redshift range with $n_{\rm AGN}<200$ are not plotted because of very large uncertainty. Vertical dotted lines show boundaries of redshift ranges. [*Bottom panel*]{}: $r_0$ against BH mass for the samples of threelow redshift ($z=0.1$–$0.3$, red squares) and intermediate redshift ($z=0.3$–$0.6$, green circles). For higher redshift sample ($z=0.6$–$1.0$), the estimated error is too large to see the dependence on BH mass. We summarize the estimated $r_0$, $\langle \rho_0 \rangle$ and $\langle n_{\rm bg} \rangle$ for the each mass range and redshift range in Table \[Tresult\].

To remove the possible redshift bias, we also present the mass dependence for sub-samples with the normalized redshift distributions. We constructed sub-samples as follows: For redshift bins with $\Delta z=0.1$, the selection probability is determined to give the same redshift distribution for the four mass ranges. We randomly selected AGN samples following the selection probability and constructed a sets of sub-samples. Figure \[subsample\] shows one example of the sub-sample. We constructed ten sets of sub-samples and measured $r_0$


for them. For these sub-samples, there is no correlation between redshift and BH mass.

Figure \[m-r\_subsample\] shows the mass dependence of $r_0$ for the resampled AGNs with normalized redshift distribution. We plot medians of the ten sets of sub-samples as green circles. Error bars show maximum and minimum values for the ten sets. The resampled AGNs also show similar mass dependence as Figure \[m-r0\]. Large mass SMBHs show strong clustering amplitude at ${M_{\rm BH}}>10^8{\, M_\odot}$. The clustering amplitude for AGNs with $\log({M_{\rm BH}}/{\, M_\odot})=6.5$–$7.5$ and $7.5$–$8.2$ is the almost same although the error bars are very large. The relative mass dependence for the sub-samples is free from redshift bias since the sub-samples for the four mass ranges have the same redshift distribution. We note that there is neither correlation between BHisolated galaxies by secular processes. If they have grown by secular processes, mass of a seed BH should be much larger than a typical stellar mass BH [for a review, see, e.g., @Volonteri10]. Some authors [@Lodato06; @Begelman06] argue that SMBHs with $10^4$–$10^6{\, M_\odot}$ are formed through the direct collapse of pre-galactic gas at $z>$10. Such a heavy seed BH can grow to $\sim10^7$–$10^8{\, M_\odot}$ by a few Gyrs without BH merger under the assumption that the mass accretion rate is around $\sim0.1$ times the Eddington rate. Another scenario would be that they are in a growing phase by the major mergers of galaxies.

For the clustering amplitude of less massive SMBHs, the contribution of the AGNs hosted in satellite galaxies in the massive dark-matter halos can also be important,


Shion had worked. We invited him and some of the other guys out for more drinking after they finished work. We ended up going to a karaoke bar and Shion and I hit it off. He was your typical Host; anime-styled hair, fashionable (yet ridiculous clothes, good looking, skinny. But he had half-sleeve tattoos on both of his arms, and I’ve always had a thing for tattoos. After hanging out a few times, it was set up that Shion and I would end the night in a Love Hotel. (By the way, he didn’t speak English, and my Japanese was still awful at the time, so that’s why it was set up with one of the other guys who spoke English, and of course, Hannah.)

So we were off!it on, as people do, and about halfway through, there was a strange noise coming from nearby. We both noticed it, looked around briefly, and then kept going. We finished, but the noise had not stopped. I sifted through the items by my futon, the pile of junk, and oh yes, of course, somehow my vibrator had switched on. I pulled it out to turned it off, and out of nowhere, this cartoon character of a man, someone that hadn’t spoken 3 words to me in English, the guy that couldn’t order fries with his Big Mac if his life depended on it, Shion yelled, ‘Laura!…. Masturbation!!’

AWESOME.

Guest house with walls of cardboard and the monolingual gent in bed with me manages to yell my name at the top


to be read,) and the OS makes a note of what the process is waiting for.  For a sleep, the process is waiting for an alarm to go off, or it may just yield again each time it's restarted until the timer is up.
Since the OS only resumes processes after something causes it to preempt a running process, such as the process yielding or the hardware timer interrupt i mentioned, sleep() is not very accurate, how accurate depends on the OS or hardware, but it's usually on the order of one or more milliseconds.
If more accuracy is needed, or very short waits, the only option is to use the busy loop construct you mentioned.

A:

The operating system schedules how processes run (which processes are eligible toEMBASE and CENTRAL for evaluation of interventions, MEDLINE is the most popular database and identifies the majority of included studies. It is noted, however, that the use of MEDLINE alone is often insufficient \[[@CR21]\].

Our objective was to develop a search hedge for degenerative cervical myelopathy in the MEDLINE database. Our priority was sensitivity, with a view that from this foundation, systematic reviewers could focus their strategies.

Method {#Sec2}
======

Study overview {#Sec3}
--------------

As per previous hedge development studies \[[@CR15], [@CR22]\], a diagnostic test assessment framework was used, whereby the hedge was developed initially using a 'development dataset' and subsequently validated in a 'validation dataset' (Fig. [1](#Fig1){ref-type="fig"}).Fig. 1Study Overview. Three development datasets were made using the publications from lead spinal journals; *Spine, Spinal Cord, Journal of Neurosurgery: Spine, Journal of Spinal Disorder's and Techniques


the potential to very accurately select articles of relevance and improve efficiency. At present, the areas closest to use by non-specialists, are tools to improve the efficiency of title and abstract screening in systematic reviews. These include Abstrackr \[[@CR44]\], Revis \[[@CR41]\] and EPPI Reviewer tools \[[@CR42]\]. These are tools which could be used to optimise a sensitive search filter.

Our objective was to develop a search filter for DCM in MEDLINE that could form the basis of any DCM systematic review and therefore we prioritised sensitivity over all other performance metrics. Whilst this limits its usability for clinicians on a day to day basis, the intention is that no relevant studies are excluded, and that the adjuvant search strategy will improve the specificity / precision for the researchers' needs.

Whatare the limitations of this filter? {#Sec14}
----------------------------------------

The generalisation of a search filter will be dependent on the database it was developed from. Investigators balance creating a database which is representative of the literature as a whole, with including sufficient target articles and remaining of a size which is amenable to hand searching. Various strategies have been employed; most commonly author selected journals, but also citation chasing and systematic reviews. \[[@CR18]\]

This initial author selection process is therefore a potential limitation to generalisation. In this study, we used a combination of previous strategies, including key journals, an exploded MESH term, narrative and systematic reviews, to minimize this risk. In addition, given the search filter's performance was maintained across many other journals and years of medical literature during validation, we therefore


Elevated catecholamine levels and abnormal hypoxic arousal in apnea of infancy.
Arousal from quiet sleep in response to a hypoxic challenge fails to occur in many patients with apnea of infancy. It was hypothesized that catecholamine-mediated responses might be involved in the depressed hypoxic arousal response in apnea of infancy and that these differences would be reflected in serum catecholamine concentrations. Fifteen infants with a median age of 5.5 months and a history of unexplained apnea during sleep were studied. Two hypoxic challenges (PiO2 80 mm Hg) were given for three minutes or until arousal from quiet sleep occurred. Of the 15 patients with apnea of infancy 11 (73%) did not arouse to hypoxia. These infants had serum epinephrine levels that were elevated 4.1-fold while awake (P less than            Opinion of the Court

¶4            In August 2014, the ROC moved to dismiss the case, alleging
Ramsey was not eligible for compensation from the Fund because she had
not suffered any “actual damages” within the meaning of A.R.S. §§ 32-1132
and -1136(E) because the amount she spent to complete the Residence —
$52,101.29 — was significantly less than the approximate $130,000 balance
owed on her contract with the Edens. Ramsey objected to the request for
dismissal and applied for an order directing the ROC to compensate her
from the Fund.

¶5            The trial court treated the ROC’s motion as an objection to
Ramsey’s application


                                   4
                             RAMSEY v. AZROC
                             Opinion of the Court

residential structure.” A.R.S. § 32-1132(A).2 The phrase “actual damages”
is not defined; therefore, we defer to the implementing agency’s
interpretation so long as it is “based on a permissible construction of the
statute.”                RAMSEY v. AZROC
                            Opinion of the Court

¶14            If, on the other hand, the initial cost of the contract remains
$100,000 and the amount paid to contractor A remains $10,000 but the
reasonable cost for contractor B to correct contractor A’s mistakes and
complete the garage is $120,000, the homeowner may be eligible to recover
from the Fund because, as a result of contractor A’s breach, homeowner has
to pay $130,000 for a garage worth $100,000. Under these circumstances,
the homeowner


222 Ariz. 515, 535-
36, ¶ 61 (App. 2009) (approving a jury instruction on the available measure
of damages that “reflected the true economic loss” of the injured
landowners and rejecting an alternate theory that would result in a windfall
at the defendants’ expense) (citation omitted); Restatement (First) of
Contracts § 346 cmt. b (prohibiting an award of damages that would result
in economic waste, or “cost[s] that would be imprudent and
unreasonable”), and the statute’s own limiting language, see A.R.S. § 32-
1132(A) (“[D]amages . . . shall not exceed an amount necessary to complete
or repair a residential structure or appurtenance within residential property
lines.”).

                               Edens’ performance. Such a finding was
immaterial under the court’s erroneous interpretation of A.R.S. § 32-
1132(A). See supra ¶ 5. These and any remaining factual matters are best
handled on remand.

                                        10


unable to find a way to resolve the Saskatchewan cash advances loan problem. However, to avoid defaults or the threats of Delisle bankruptcy, you can find an effective debt consolidating solution through the use of debt consolidation Delisle programs.

The reasons so many Delisle people find themselves in garbage financial Delisle financial trouble are plentiful. For some there are circumstances like divorce, loss of Saskatchewan employment or medical expenses that can create the situation of being in serious Delisle debts with creditors. For others it could be from the result of not having enough Saskatchewan personal savings, gambling, or poor Delisle hard earned dollars management.

Regardless of why people find themselves in these types of Delisle SK financial troubles will not matter, as people can put an end to theinvestments, or Saskatchewan poor hard earned dollars management, these Delisle consolidation loans are the best and most effective debt consolidation Delisle programs that are helping thousands of Saskatchewan people to resolve the issues of Saskatchewan financial difficulties.

If you are in Delisle debts, you need to take realistic action quickly to correct your Delisle debts problems. You need to start dealing with your Saskatchewan debts problems by working out how much hard earned dollars you owe, whether you have enough Delisle hard earned dollars to pay off your Delisle fast cash and if you have any urgent Delisle debts. Understanding your exact financial trouble situations is crucial to take the right steps for solving your Saskatchewan debts issues. You should deal with urgent bills such as Delisle Saskatchewan turbo


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Millions of people struggling with Saskatchewan debts problems are looking for a viable consolidation loans option to get out of debts. A Delisle debt relief loans program can be the right option under difficult circumstances to help you sort out your Delisle Investment garbage and get out of financial trouble eventually without incurring further Saskatchewan swift personal loan. It is very important for you, however, to choose a very reliable Saskatchewan debt consolidating firm to start anyand jot them down. The consolidation of your Delisle cash advances loan will make sense if your new rate is lower in Delisle than the old rate for each one of your credit cards. However, if you find that some Delisle cards have lower rates, then you should avoid consolidating your debts. Some of us like to keep things simple, and Saskatchewan debt consolidating is a great way to achieve it. You will cut out a lot of abrupt consolidation loans stress if you just have to pay one Delisle debt consolidating bill.


are 50/50 RP/Combat.

About Me

Biography:

I have been playing RPGs for over 30 years. D&D is one of my favorites and the one I have played almost every years since I started playing RPGs. The list of other games I have played is way to long to list, but if I haven't played it I always willing to learn.for people who care about the West

Dodged bullets

How the Bush administration shot -- and missed -- on some Western issues

THE DODGEUnder the banner of deficit reduction, in 2005, Rep. Jim Gibbons, R-Nev., and Rep. Richard Pombo, R-Calif., tried to overturn an 11-year moratorium on selling federal land to mining companies. Their proposal would have let companies buy public land for as little as $1,000 per acre, then potentially sell it for development. Outraged hunters and conservationists convinced Western politicians to sink the proposal.

The next year, Bush floated a budget proposal directing the Forest Service and BLM to generate more than $1 billion by selling off land. Again, Western politicians killed the idea.

RELOAD FACTOR*

5 bulletsDespite the burgeoning deficit, this idea isn't likely to return under the Obama administration. In


the fact there were no, I mean no, wounded people taken to hospitals. And finally, you add to that the big to-do about the amputee. He turned out to be a hired actor for a company that specializes at putting amputees into battle field simulations. False flag. Boston was a practice attempt to lock down an entire city.”

Beg. at the 8:44 mark, Steele said: “the actual bomb was a theatrical device. You don’t buy gun powder at a fireworks store to create a bomb. It just is not done. I had my explosive ordinance people look at this. Everybody laughed at this. This was school kids stuff. THERE WAS NO BOMB. There were no injuries. This was a false flag.”

Steele continues: “And now we’re seeing 9/11 unravel, andaspects of both theories to operate and the receding horizon model falls between the expansion and compression of morbidity models and proposes that the onset and progression of morbidity is postponed to exactly the same extent as death so that the number of years spent in poor health remains unchanged.[@R3]

The findings of research into this issue vary according to the health outcome, the type of data used (cross-sectional or longitudinal), social class and across countries, perhaps reflecting different social, cultural and political contexts.[@R4] Furthermore, there is considerable uncertainty as to how health trajectories at older ages might be affected by the changing prevalence of risk factors such as obesity, sedentary lifestyles, smoking and alcohol consumption.[@R4] A weakness of existing studies, particularly in the UK, is that they have


subsequent change in frailty between waves 1 and 5 (2002--2010) dependent on cohort at wave 1. Our multilevel model consists of repeated observations nested within individuals, offering one way of dealing with the non-independence of an individual's level of frailty over time. A key advantage of using a multilevel approach is that the technique is capable of handling unequal time spaces, missing data, and the inclusion of time varying and between-subject covariates that are either continuous or discrete measures.[@R23] We use a similar methodology to that in a study of depression in later life[@R24] to investigate whether cohorts share the same or different frailty trajectories. We extend this methodology to consider whether cohort-specific trajectories differ by gender and wealth.

The models fitted are specified below (equations 1--5) where FI~ti~indicates the frailty index of individual i at time t for i=1...11 220 and t=1...t~i~; t~i~ is the number of repeated measures available for individual i and ranges from 1 to 5 depending on the number of survey waves that an individual participated in (see online [supplementary material](http://jech.bmj.com/lookup/suppl/doi:10.1136/jech-2014-204655/-/DC1) for more details on missingness). In the level 1 repeated measures model (equation 1), each individual\'s frailty trajectory is modelled as a function of time, where time~ti~ denotes the timing of occasion t for individual i and is based on a centred version of survey wave (time=−2, −1, 0, 1, 2; see elsewhere for details on variable centring[@R25]). We include a quadratic term, , to allow for the development of non-linear frailty trajectories. Thus, in equation 1, the intercept β~0i~ gives


the mean frailty index of person i in wave 3 while β~1i~ and β~2i~ give the linear and quadratic growth of frailty over time for individual i. In equation 1, e~it~ is the random within-person error for person i at time t, which is assumed to be normally distributed. The level 2 model (growth trajectories across individuals) allows for a distinct trajectory for each age cohort (equations 2 and 3). Here, cohort~i~ indicates the cohort membership of individual i and is treated as a (centred) continuous variable taking the values −3, −2, −1, 0, 1, 2 and 3. Operationalisation of cohort using dummy variables gives similar results and identical conclusions. We experimented with inclusion of a cohort squared term but this was not statistically significant so we didleft little doubt.

In the first indictment Swartz had been charged with one count each of wire fraud (maximum prison sentence: twenty years), computer fraud (maximum prison sentence: five years), theft of information from a computer (maximum prison sentence: five years), and recklessly damaging a computer (maximum prison sentence: five years). The superseding indictment now charged him with one count of recklessly damaging a computer (maximum prison sentence: five years), two counts of wire fraud (maximum prison sentence: forty years), five counts of computer fraud (maximum prison sentence: twenty-five years), and five counts of unlawfully obtaining information from a protected computer (maximum prison sentence: twenty-five years). All but the wire-fraud charges were brought under the Computer Fraud and Abuse Act. The government manufactured these new counts by treating the


that has been good to me and my family.There was a point in my life last year that I realized that I needed more though. At the time, the decision to go back to school was purley personal. The past 9 months of blogging, answering emails and connecting with you was purely to help spread the word about health and nutrition. What a beautiful and eye-opening 9 months it has been! I have realized over these months that the need for what I am learning is much more than I could have ever imagined. The impact I could have, that you could have, can be even greater.I love what I do now, I have amazing clients that I work with in my full-time job. But I recognize that(Block)blockIt.next();
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            if (size instanceof IntConstant)
    Q:

Desperately Need Advice on Converting Date Column

I have a dataset that has mixed data types in the Date column.
For example, the column looks like this:
ID     Date
1     2019-01-01
2     2019-01-02
3     2019-11-01
4     40993
5     40577
6     39949

When I just try to convert the column using pd.to_datetime, I get an error message "mixed datetimes and integers in passed array".
I would really appreciate it if someone could help me out with this! Ideally, it would be nice to have all rows in 'yyyy-mm-dd' format.
Thank you!

A:

I'm guessing those are excel date format?
Convert Excel style date with pandas
import xlrd

def read_date(date):
    try:


Nick Cave has said he decided to perform in Israel to take a stand against “those people that are trying to silence musicians”.

The Bad Seeds frontman said it was in protest of the Boycott, Divestment, Sanctions (BDS) movement that he agreed to play two shows in the country.

The band has faced criticism from outspoken critics of the Israeli government, including Pink Floyd’s Roger Waters and Sonic Youth’s Thurston Moore, ahead of its shows in Tel Aviv.

Get The Jewish News Daily Edition by email and never miss our top stories Free Sign Up

In an open letter to Cave, Artists For Palestine UK – which counts Moore and Waters among its members, urged him to cancel the show “while apartheid remains”.

In a press conference in Israel, Cave said he had!!!! and also the more time in delay getting it built means more and more traffic growth ,I should No I travelled up and down to work back in 1973 on the A48 Newport to Cardiff when we had NO M4 and I saw accidents every week some fatal which I saw many time's..
People don't like public transport as it takes far to long to get from A to BJonnytrouble

keithbob wrote:
as i have commented before,yes bad driving is to blame,but the tunnels are the main course of the problems.three lanes into two and a 50 m.p.h. permament speed limit is a recipe for disaster.worst designed length of motorway on the map.

What is a major problem is that all of a sudden, people see the tunnels and brake, slowing


cab or even just an hour to appreciate what the driver goes through as the channel 5 program still doesn't cut it. As a truck driver you have to plan so far in advance and car drivers just completly screw with that. I would bet you that the vehicle that was seemingly too close was either about to overtake or has not long been overtaken. Being a lorry driver is all about you against every other vehicle type driver on the road. Nobody understands like a truck driver what the loss of momentum (when waiting to overtake) means. You can be planning to overtake, be looking in your mirrors looking for a gap for a long time before you actually pull out, so you've spotted the gap andyou indicate and you pull straight out because you know full well that nobody will let you out and if you wait you loose all your momentum, miss the chance to overtake and then have to build up speed again. When I first drove the lorry I had to stop at the aust services because I thought my indicator bulbs weren't working but they where, having stopped again near reading I decided that it wasn't faulty bulbs but nobody paying attention. So next time you think that that truck driver has just pulled out in from of you without barely a signal, ask yourself if you would have actually let him out. You can bet your left arm that although 3 blinks of the indicator was all you


you loose all your momentum, miss the chance to overtake and then have to build up speed again. When I first drove the lorry I had to stop at the aust services because I thought my indicator bulbs weren't working but they where, having stopped again near reading I decided that it wasn't faulty bulbs but nobody paying attention. So next time you think that that truck driver has just pulled out in from of you without barely a signal, ask yourself if you would have actually let him out. You can bet your left arm that although 3 blinks of the indicator was all you got the guy driving the truck would have been well aware of the situation. If you do get cut up by lorriesnew section of motorway.

You need to spend a day in a truckers cab or even just an hour to appreciate what the driver goes through as the channel 5 program still doesn't cut it. As a truck driver you have to plan so far in advance and car drivers just completly screw with that. I would bet you that the vehicle that was seemingly too close was either about to overtake or has not long been overtaken. Being a lorry driver is all about you against every other vehicle type driver on the road. Nobody understands like a truck driver what the loss of momentum (when waiting to overtake) means. You can be planning to overtake, be looking in your mirrors looking for a gap for a long


modules, which could be diet and healthy eating, manual handling or any other that the training company makes up. Through no fault of my own, I have covered the same subject 3 times. There is no set syllabus. Can you imagine having driving lessons and just covering hill starts for your entire time ?Dolieboyand atmospheric music.

A demo was released 20 July 2007, and premiered at E3. The game was first published by DreamCatcher in the United States, and afterwards by New Disk in Russia. Atari France distributed the games in France. A fan-made Czech localisation of the game was made in 2008.

The game was included in a 2014 Humble Bundle.

Streko-Graphics would retroactively say that game had a subpar management, which they only realised late in the production process. It puts this down to the game having a less favourable reception than anticipated. The game had a planned release on Xbox, but the team did not realise how much work it would take to make a separate version of their game.

Critical reception
Streko-Graphics believes that the game had a "mediocre" reception in


insurance companies try to compensate for the loss of federal subsidies that helped underwrite those plans. In some cases, that could make silver plans more expensive even than gold plans, which provide more generous coverage.

People like the Purvances who pay full price for their insurance will likely be unable to avoid paying more for their plans — which could discourage people from signing up. Robert Laszewski, a health policy consultant, said that insurance companies expect 20 percent of those who pay full price for their coverage to leave the market over the next year. One carrier described the situation to him in stark terms: "Our unsubsidized market is melting."

Meanwhile, the lower-income Americans who would seem to be most at risk from Trump's decision to end the federal paymentsmm and 2.57 mm in nasal base width (posterior, middle and anterior slices, respectively) and of 2.11 mm, 1.60 mm and 1.77 mm in nasal cavity width (posterior, middle and anterior slices, respectively). These increases were significantly higher in comparison to the control group. In assessing the increase in the inferior nasal cavity area, no significant difference was observed between treated and control groups. The only CBCT study[@B21] included in this systematic review[@B19] assessed changes in retropalatal and retroglossal airways volume after RME. They found no significant difference between treated and control groups; however, maxillary width increased significantly in the RME group. The authors stated that a possible bias in this retrospective study was the absence of control over tongue position when the CBCT scans were taken. In


The Drop-Outs March Lyrics

by Allan Sherman

No more pencils, no more books
No more teachers dirty looks
Dropouts, dropouts, yeah team

On dropouts down the field
Ain't we the national shame
Cheer for our fun-loving breed
Who can't hardly read
Or write our name

March dropouts, backward march
Ain't we a tragedy
Leave us unite and fight, fight, fight
For good old stupidity

Duh
Duh

Drop dropouts out of school
Proud of the will to fail
You won't find us in the school halls
Look in the pool halls or in jail

Long may our colors wave
Sons of the black and blue
Light-hearted chaps who steal hubcaps
We've got nothing else to do

Ignoramus there you are
Sitting in your hopped-up car
And your brains ain't up to par
And your ears stick out too far

Go dropouts, go and buy
One comic book or two
You need some rest and enjoyment
Your unemployment check is due

Soonas near-infrared fluorophores for selective recognition and imaging of CD20-expressing Raji B-cells (Liu Z, Robinson J T, Sun X M, Dai H J. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc 2008, 130(33): 10876-10877).
Despite its highly anticipated potentials, GQDs have yet to be used to specifically label and track molecular targets involving in dynamic cellular processes in live cells.


              context.clearRect( l, 0, w, canvasHeight/3);
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            }
        }
        dojo.forEach( pixels, function(p,i) {
            if (!p) {
                // if there is no data at a point, erase the mask.
                context.clearRect( i,according to ethical principles of the University of Jyväskylä,^[@R36]^ and research guidelines provided by the National Advisory Board on Research Ethics in Finland.

RESULTS
=======

Characteristics of the Participants
-----------------------------------

Most participants were male (83.4%) and local forest officers (47.1%), as summarized in Table [1](#T1){ref-type="table"}. Other personnel groups were executives (14.5%), officers (18.9%), terminal workers (12.5%), and lumberjacks (5.8%). At baseline, 586 people completed HRA and 65 declined. At follow-up, proportions were 419 participants and 111 decliners. The selected baseline HRA results were the following: mean body mass index 26.9, systolic blood pressure 137 mm Hg and diastolic blood pressure 79 mm Hg. The mean VO~2~max results were 33.6 mL/kg/min females and 38.7 mL/kg/min males resulting in an overall fitness class of 4.2 based on the Shvartz and Reibold scale of 1 to 7.^[@R37]^

Design Evaluation
-----------------

### Size

According to


contacts with a duration of 3 to 6 months. Employees with a good health status were offered group services with minimal life change support. The more specific descriptions of single size components are presented in appendix 1 (see Supplemental Digital Content 1). As an overview, the duration of the services ranged from a day to several months and the most common method of delivery was a face-to-face meeting or phone calls.

The program aimed "to promote life changes...and with time decrease the number of low health status and increase the number of moderate and good health status.^[@R38]^" However, the exact amount of the reduction in low health status was not set in the program plans. Health improvements were expected to occur in BodyAge measurement components,^[@R34]^ and as a lifechange process indicator, the TTM was used.^[@R30]^

To sum up the size, the provider and the employer shared a common goal of empowering employees in taking care of their own health behavior. The most individual support was offered to the lower health status people.

### Scope

According to the design findings, the provider attach great importance to a broad range of services during years 2010 to 2013 (see Appendix 1, see Supplemental Digital Content 1). The services were planned only for the needs of the employees of Stora Enso Metsä; subcontractors or family members were not under a scope. The main focus of the services was to support low-effort, pleasant life changes. Top athlete habits were not emphasized. The nutrition services focused on three main areas: increasing the use of vegetables


and fruits, balancing daily meal patterns, and adopting a healthy diet without excess stress. The physical activity part concentrated on easy and safe daily activities, for example, Nordic walking and cycling.

To summarize, the provider established a large scale of services for all employees. The main scope was on life change, nutrition, and physical activity.

### Scalability

The provider hoped to capture a 100% reach out to the program across all the 120 units. The aim was to have everyone participate, at least once a year into an annual WHP event or into targeted services, even though the participation was voluntary. Several communication tools were planned to increase awareness of the program and willingness to participate. According to the marketing plans, every local office should be sent a campaign poster duringof these emails were opened and read by the recipients, and readability check-up tools were not used in this study.

Implementation
--------------

Implementation demonstrates how well the program was delivered to the target population as planned. The implementation coefficient was calculated by dividing actions executed by all intended actions (see Fig. [2](#F2){ref-type="fig"}).

![Planned versus executed actions of ENSO during years 2009 to 2014.](joem-59-0752-g002){#F2}

Altogether, 73 actions had been planned for the years 2009 to 2013, of which 59 were executed, resulting in a total coefficient of 80.8% for implementation. Of planned actions, 44 were services, four were HRAs, 12 were communication tools, nine were materials, and four were cooperation ideas. The highest implementation percentage was found in HRA\'s and communication tools, where all planned actions were executed. In services, 33 of 44 planned


emphasizes relevance to participants.^[@R19]^ Clearly, the decision to target all employees with several services is not supported with one consent in the literature. The analysis of the last components of the PIPE Impact metric, the *participation* and the *effectiveness*, is needed to brighten a final judgment of design decisions behind ENSO.

The ENSO program started with a HRA and feedback. HRA is a common and effective tool in WHP programs,^[@R6],[@R9],[@R18]^ but not sufficient by itself.^[@R16]^ Soler et al^[@R16]^ found strong evidence of effectiveness, when HRA was conducted in combination with health education or connected to targeted services. These findings support the actions selected in ENSO.

In the literature, *scalability* and *penetration* are connected in the sense that high penetration measures the success of scalability design.^[@R23]^ ENSO aimed at 100% scalabilityInterestingly, the recommendations in the literature have emphasized the need to ensure fidelity of program implementation,^[@R6],[@R9],[@R18],[@R19]^ but implementation calculations are not routinely reported in published WHP interventions. As a benchmark result in primary care, implementation levels over 60% had led to positive outcomes and few studies obtain fidelity levels over 80%.^[@R40],[@R41]^ Future studies should report implementation rates more clearly and investigate the connection between implementation rates and effectiveness calculations.

On the basis of the comparison between the design process and the nine Best Practice principles, the strengths of ENSO were comprehensiveness, relevance to employees, solid life-change message, multiple communication tools, and data-driven execution.^[@R19]^ Engagement and "culture of health" was at good level already before ENSO started, but it strengthened even more because of the tailored program branding, shared design


gathered information treated ENSO as "a whole" combining research and practice.

To summarize the study results, most of the program content was executed as planned (81%) and there were no major deficiencies in the design of ENSO compared with present literature recommendations. However, analyses on participation and effectiveness will be needed in order to measure final outcomes of the program. Overall, study findings indicate that WHP market would benefit the use of evidence based design principles for benchmark and quality improvement purposes and WHP providers should intentionally prepare for long-term actions already during the planning.

Supplementary Material
======================

###### Supplemental Digital Content

Supplementary Material
======================

###### Supplemental Digital Content

The authors want to kindly thank Jouni Lahti PhD, Adjunct Professor, Department of Public Health, University of Helsinki for double-checking collected design data, 4-S classifications, and thePizza, Inc., alleging violations of
federal antitrust laws, breach of contract, and tortious
interference with contract. The district court dismissed the
antitrust claims under Fed. R. Civ. P. 12(b)(6) for failure to
state a claim for which relief can be granted, because the
plaintiffs failed to allege a valid relevant market. The
district court declined to exercise supplemental jurisdiction
over the plaintiffs' remaining common law claims. Queen
City Pizza, Inc. v. Domino's Pizza, Inc., 922 F. Supp. 1055
(E.D. Pa. 1996). We will affirm.

I. Facts and Procedural History

A.

Domino's Pizza, Inc. is a fast-food service company that
sells pizza through a national network of over 4200 stores.
Domino's Pizza owns and operates approximately 700 of
these stores. Independent franchisees own and operate the
remaining 3500. Domino's Pizza, Inc. is the second largest
pizza company in the United States, with revenues in
excess of $1.8


billion per year.

A franchisee joins the Domino's system by executing a
standard franchise agreement with Domino's Pizza, Inc.
Under the franchise agreement, the franchisee receives the
right to sell pizza under the "Domino's" name and format.
In return, Domino's Pizza receives franchise fees and
royalties.

The essence of a successful nationwide fast-food chain is
product uniformity and consistency. Uniformity benefits
franchisees because customers can purchase pizza from

                                  3

any Domino's store and be certain the pizza will taste
exactly like the Domino's pizza with which they are familiar.
This means that individual franchisees need not build up
their own good will. Uniformity also benefits the franchisor.
It ensuresId. at 1062. For that
reason, plaintiffs' claims "implicate principles of contract,
and are not the concern of the antitrust laws." Id. The
district court also held plaintiffs had failed adequately to
allege harm to competition, "a bedrock premise of antitrust
law." Id. at 1063. Because plaintiffs failed to assert a
cognizable antitrust claim and there was neither diversity
among the parties nor special circumstances justifying
exercise of supplemental jurisdiction, the court dismissed
without prejudice plaintiffs' common law claims for lack of
subject matter jurisdiction. Id. at 1063-64.

The district court granted plaintiffs leave to file an
amended complaint to cure the jurisdictional pleading
deficiencies in their state law claims. Plaintiffs decided not
to replead their state law claims. Instead, they sought to
amend their complaint for a second time in an attempt to
state a valid federal antitrust claim. The district court
denied their


burden of defining the relevant market.
Pastore v. Bell Telephone Co. of Pennsylvania , 24 F.3d 508,
512 (3d Cir. 1994); Tunis Bros Co., Inc. v. Ford Motor Co.,
952 F.2d 715, 726 (3d Cir. 1991). "The outer boundaries of
a product market are determined by the reasonable
interchangeability of use or the cross-elasticity of demand
between the product itself and substitutes for it." Brown
Shoe Co. v. U.S., 370 U.S. 294, 325 (1962); Tunis Brothers,
952 F.2d at 722 (same). Where the plaintiff fails to define
its proposed relevant market with reference to the rule of
reasonable interchangeability and cross-elasticity of
demand, or alleges a proposed relevant market that clearly
does not encompass all interchangeable substitute
products even when all factual inferences are granted in
plaintiff 's favor, the relevant market is legally insufficient
and a motion to dismiss may be granted.S 2 of the
Sherman Act, 15 U.S.C. S 2. Section 2 sanctions those "who
shall monopolize, or attempt to monopolize, or combine or
conspire with any other person or persons, to monopolize
any part of the trade or commerce among the several
states, or with foreign nations." "The offense of monopoly
under S 2 of the Sherman Act has two elements: (1) the
possession of monopoly power in the relevant market and
(2) the willful acquisition or maintenance of that power as
distinguished from growth or development as a
consequence of a superior product, business acumen, or
historic accident." Aspen Skiing Co. v. Aspen Highlands
Skiing Corp., 472 U.S. 585, 596 n. 19 (1985) (quoting
United States v. Grinnell Corp., 384 U.S. 563, 570-71
(1966)). See also Ideal Dairy Farms, Inc. v. John Labatt,
Ltd., 90 F.3d 737, 749 (3d Cir. 1996)


proposed relevant market.

Of course, Domino's-approved pizza ingredients and
supplies differ from other available ingredients and supplies
in one crucial manner. Only Domino's-approved products
may be used by Domino's franchisees without violating
section 12.2 of Domino's standard franchise agreement.
Plaintiffs suggest that this difference is sufficient by itself to
create a relevant market in approved products. We
disagree. The test for a relevant market is not commodities
reasonably interchangeable by a particular plaintiff, but
"commodities reasonably interchangeable by consumers for
the same purposes." United States v. E.I. du Pont de
Nemours & Co., 351 U.S. 377, 395 (1956); Tunis Brothers,
952 F.2d at 722. A court making a relevant market
determination looks not to the contractual restraints
assumed by a particular plaintiff when determining whether
a product is interchangeable, but to the uses to which the
product is put by consumers in general. Thus, thefrom the working of the market; it is to protect
the public from the failure of the market." Spectrum Sports,
Inc. v. McQuillan, 506 U.S. 447, 458 (1993). Here, plaintiffs'
acceptance of a franchise package that included purchase
requirements and contractual restrictions is consistent with
the existence of a competitive market in which franchises
are valued, in part, according to the terms of the proposed
franchise agreement and the availability of alternative
franchise opportunities. Plaintiffs need not have become
Domino's franchisees. If the contractual restrictions in
section 12.2 of the general franchise agreement were viewed
as overly burdensome or risky at the time they were
proposed, plaintiffs could have purchased a different form
of restaurant, or made some alternative investment.15 They
chose not to do so. Unlike the plaintiffs in Kodak, plaintiffs
here must purchase products from Domino's Pizza not
because of Domino's market


1.

To establish a section 1 violation for unreasonable
restraint of trade, a plaintiff must prove (1) concerted action
by the defendants; (2) that produced anti-competitive
effects within the relevant product and geographic markets;
(3) that the concerted action was illegal; and (4) that the
plaintiff was injured as a proximate result of the concerted
action. Mathews v. Lancaster General Hospital , 87 F.3d
624, 639 (3d Cir. 1996); Orson Inc. v. Miramax Film Corp.,
79 F.3d 1358, 1366 (3d Cir. 1996); Petruzzi's IGA
Supermarkets, Inc. v. Darling-Delaware Co., Inc., 998 F.2d
1224, 1229 (3d Cir. 1993).

Plaintiffs allege defendant's actions caused anti-
competitive effects within the market for ingredients and
supplies used by Domino's pizza stores. Again, this claim
fails because the products within the proposed market are
interchangeable with products outside the proposed
market.18

E.

Plaintiffs allege Domino's Pizza, Inc. imposed an unlawful
_________________________________________________________________

18. Monopoly powerthe market for the tying
product to force buyers to purchase the tied product when
they otherwise would not, thereby restraining competition
in the tied product market." Id. "Even if a seller has
obtained a monopoly in the tying product legitimately (as by
obtaining a patent), courts have seen the expansion of that
power to other product markets as illegitimate and
competition suppressing." Town Sound and Custom Tops,
Inc. v. Chrysler Motors Corp., 959 F.2d 468, 475 (3d Cir.
1992). "The first inquiry in any S 1 tying case is whether the
defendant has sufficient market power over the tying
product, which requires a finding that two separate product
markets exist and a determination precisely what the tying
and tied products markets are." Allen-Myland, 33 F.3d at
200-201.

Here, plaintiffs allege Domino's Pizza, Inc. used its power
in the purported market for Domino's-approved dough


in
policy in Kodak was the crucial factor in the Court's
decision. By changing its policy after its customers were
`locked in,' Kodak took advantage of the fact that its
customers lacked the information to anticipate this
change."), cert. denied, 1997 WL 195257; see also Digital
Equip. Corp. v. Uniq Digital Techs., Inc., 73 F.3d 756, 763
(7th Cir. 1996); Lee v. Life Ins. Co. of North America, 23
_________________________________________________________________

4. This conclusion seems quite sensible. If Kodak customers knew about
Kodak's subsequent parts-and-service policy when they bought the
copiers, or were not economically restricted from switching to other
copiers, then Justice Scalia's dissent, which assumes a perfect
competition/perfect information world, should be right. Kodak is merely
a concession to fact that markets do not always work perfectly, and
sometimes, but not always, these imperfections can create sufficient
market power to justify possible antitrustthe line

"There's been a murder," I said, and then I gave the address. I was a pithy motherfucker, and my stupidity was all over the place. My pants were stained with her blood, and my name was indelible, strung across the wall above us.

The whiskey spritzed away at the flame of hangover. The pain smoldered.

I thought about the cops and that motherfucker Tax. As if you didn't think of him too.

I stood there next to the corpse, drinking liquor that tasted like fingernail polish remover, lurking under the graffiti of my own name. I like to try to picture it from the ghost's perspective, from your perspective, from the cops'. I'd make some assumptions too.

I let myself out the back door and booked it over to New Jersey.


Integrated Care in Chronic Obstructive Pulmonary Disease and Rehabilitation.
Individuals with advanced chronic obstructive pulmonary disease (COPD) often have complex medical problems that require more than simple pharmacological therapy to optimize outcomes. Comprehensive care is necessary to meet the substantial burdens, not just from the primary respiratory disease process itself, but also those imposed by its systemic manifestations and comorbidities. These problems are intensified in the peri-exacerbation period, especially for newly discharged patients. Pulmonary rehabilitation, with its interdisciplinary, patient-centered and holistic approach to management, and integrated care, adding coordination or transition of care to the chronic care model, are useful approaches to meeting these complex issues.
Nuclear power is the fastest way to slash greenhouse gas emissions, decarbonize - jseliger
https://www.nytimes.com/2019/04/06/opinion/sunday/climate-change-nuclear-power.html
======
scarygliders
Can we just get something straight about the Fukushima Dai-ichi nuclear power
plant?

Although it was a 1960's design, the reason it failed the way it did was
because of one design flaw...

Its backup generators were not placed up on the hills above it. Rather, the
backup generators were situated below sea level underneath the reactor
buildings. DERP.

Fukushima Dai-ichi survived the Magnitude 9 earthquake. It did not survive the
tsunami because said tsunami overcame the tidal wall in front of it, and then
the backup generators got flooded. But for that one event, if the generators
were placed up on higher ground, the outcome would have been so much
different.

I have first-hand knowledge, due to..

1) Knowing the area. I lived in my Japanese father-in-law's


continue
to do so.

It boggles my mind that the nuclear industry itself demands that all disaster
cleanup costs over $300 million be shouldered by the government yet it is
trying to project an image of how it is the "safe" option. If they don't have
enough faith in their own safety to raise the cap why should we?

~~~
ElBarto
Calculate how many wind generators you need to guarantee the same production
as Hinkley point and you'll see that it is not really realistic.

Then, take into account the goal of making of vehicles electric in the next 20
years.

There is no viable alternative to nuclear as of today even if renewables
should of course be pushed as much as possible.

Germany is emitting heavily because most of its electricity comes from fossil
fuel and it decided to kill nuclear powerfactors for wind turbines are rarely over 40%. Nuclear's is 80%. So you'd
need 2200 turbines to replace one Hinkley point. And all the gas power plants
to make the energy when the wind is not blowing...

~~~
logifail
> Nuclear's is 80%

Why is that?

I'm sure we're all broadly in favour of free markets. Do electricity consumers
buy nuclear because it's good value?[0]

[0] [https://www.theguardian.com/news/2017/dec/21/hinkley-
point-c...](https://www.theguardian.com/news/2017/dec/21/hinkley-point-c-
dreadful-deal-behind-worlds-most-expensive-power-plant)

~~~
joss82
Because the nuclear reaction is not dependant on the wind blowing to produce
energy.

It's not 100% because you need to do maintenance at times.

~~~
logifail
> the nuclear reaction is not dependant on the wind blowing to produce energy

Perhaps I wasn't clear enough, I was alluding to the lively debate about how
the selling price for electricity is set, and how it should vary depending on
market conditions.

I see no reason to lock-in minimum pricing for


with nuclear power, because the timeframe is long relative to
the life of a human. If the average human lifespan was 200 years or more,
maybe this would be less of an issue, but as it is now, profits now will
inevitably trump responsibility tomorrow (and by tomorrow, I mean 30+ years
from now).

There's also the risk of weaponization, which increases as the number of
plants increase, particularly if those plants are built in countries which
currently do not possess much technical nous. It's not a technology that
should be disseminated, because the risks are real, and catastrophic in their
consequences. If this sounds paranoid, Warren Buffett had this to say about
the threat of cyber, biological, nuclear, or chemical attack on in the US:

"“What’s a small probability in a short period approaches certainty in the
longer run.the billions in construction costs over decades.

If the billions spent on nuclear plants now was instantly diverted to solar,
we'd have way more clean energy in the grid on a way shorter timeline. That's
the reality today. It's time to stop arguing and stop wasting money. Nuclear
is dead.

~~~
rocqua
Is storage a solved problem yet? Afaik, dams are the only viable option, and
not universally available.

I thought batteries just weren't there yet. Especially if you take wear cycles
into account.

~~~
BluSyn
Batteries are much farther along than most realize, and decreasing in cost
rapidly. 2019 will see the first GWh-scale battery installations (plural, as
in multiple of them). Grid-scale lithium-ion battery storage is at the
beginning of an exponential growth curve.

~~~
jki275
What is the environmental cost of mining that lithium?

How much lithium is there, actually?

------
addicted
Nuclear power can save the world....

If


Richard Lester, a nuclear engineer, has written, a
company proposing a new reactor design faces “the prospect of having to spend
a billion dollars or more on an open- ended, all‑or‑nothing licensing process
without any certainty of outcomes.” We need government on the side of this
clean-energy transformation, with supportive regulation, streamlined approval,
investment in research and incentives that tilt producers and consumers away
from carbon._

...

 _[I]n 60 years of nuclear power, only three accidents have raised public
alarm: Three Mile Island in 1979, which killed no one; Fukushima in 2011,
which killed no one (many deaths resulted from the tsunami and some from a
panicked evacuation near the plant); and Chernobyl in 1986, the result of
extraordinary Soviet bungling, which killed 31 in the accident and perhaps
several thousand from cancer, around the same number killed by coalemissions
every day._

~~~
ianai
“Chernobyl in 1986, the result of extraordinary Soviet bungling, which killed
31 in the accident and perhaps several thousand from cancer, around the same
number killed by coal emissions every day.” just that is all I need to know to
prefer nuclear to coal.

~~~
est31
You shouldn't just count deaths and conclude that a nuclear catastrophy isn't
that bad. Far more people had to evacuate their home, having to leave most of
their belongings behind. And most times with no or too little compensation.
Sure, nuclear is prefferable to coal but that doesn't mean that both shouldn't
be gotten rid of.

~~~
TomMarius
But that kind of reactor is never going to be built again - its design was
very outdated and outright bad. Today we can build reactors where any failure
that would result in an explosion of any kind


of land and make them unlivable for generations. This is especially
applicable to the United States that has proven entirely unable to handle it's
own nuclear waste and just accumulates it at the sites where it's generated,
waiting for disaster to happen.

~~~
cm2187
I always thought that nuclear waste was a non problem. It is a minuscule
amount of confined hazardous material. Even if you don't recycle it, the
impact on the environment is negligible.

But I agree that the devastation of huge areas of land is a problem, but let's
also keep in mind that the reactors that blew up where early generations
reactors. More modern design do not present those risks [1]. Judging nuclear
energy based on 1960s design is like judging aviation based on the safety
records of 1930s planes.

[1]
[https://en.wikipedia.org/wiki/Generation_IV_reactor](https://en.wikipedia.org/wiki/Generation_IV_reactor)

~~~
hannob
> But I agree that the devastation ofoverlooked aspect of Nuclear is that it is the big government,
centralized, big industry, big bureaucracy, anti-freedom, anti-self-
determination option.

Renewables like solar and wind can be local, scaled down to the needs of a
single family property, and kept under the sole control, if desired, of an
individual owner. Nuclear is fundamentally not that way.

If this article isn't it already, expect to see in the near future that the
powerful elite subset of climate deniers will pivot to accept climate change
while advocating for nuclear as a solution, all because their cronies stand to
benefit from massive construction projects and associated safety, security,
and control projects.

~~~
lispm
That was one of the main reasons here in Germany to quit that type of
industry. There were people from the industry which had exposed this.

------
skrap
Strong public policy can save the world.


cost of ownership is significantly lower. Nuclear is not
required anymore.

------
cx42net
A few things annoy me on this article.

About deaths: The author says nuclear causes fewer deaths than the rest. Maybe
that's true, but he (voluntarily?) omits to take into consideration long term
health issues related to incidents. The Tchernobyl accident released
radioactve cloud that affected many people that died of cancer or are having
health issues related to it. Worse than that, it's almost impossible to track
who got sick because of those clouds. So yeah, maybe just a "small set" of
people died DIRECTLY following nuclear incidents, but long term effects cannot
be ignored just for the sake of the argument.

Next, the waste. "stored in a walmart, that degrade over time". Again, the
author omits to say the duration ... over time is an understatement here,renewable site, or by nearby countries who do not have 100% renewable.

Hydro power is the most efficient way of storing the extra energy right now.
So people talking about batteries would be talking on a much smaller scale, or
don't know what they are talking about.

A large portion of the energy currently consumed is by oil tankers that burn
crude directly during transport of goods across the ocean. The benefit is for
transportation of the energy and fueling costs. I suspect that we will need to
make energy so cheap on land and for cities that it is more cost effective to
create burnable fuel for ships than to extract the oil from the ground.

We are currently struggling to get our cities even at parity with renewable,
but maybe with the surplus renewable energy on


case if you don't work on advanced reactors is you get
screwed by climate change when running into logistical issues with renewable
intermittency.

~~~
pfdietz
Yes. MSRs are an insurance policy in case renewables suddenly stop getting
cheaper. They might have niche uses (very high latitudes, actinide
destruction), but that won't be earthshattering if we don't have it.

------
pdevine
Can we talk about the waste that’s cast off when the reactor has finished its
use of it? I understand the material will remain radioactive for centuries.
Nobody wants that in their backyard.

~~~
Lramseyer
Not to downplay the issue, but global warming is a much more urgent issue.
It's expected to cause far more disasters a lot sooner than any potential
disaster from our nuclear waste.

To answer your question more practically though, our nuclear waste would fit
into a building the size of a footballthis is a good faith opinion piece.

------
moonlet
Nuclear power can save the world if we can prevent any more Fukushimas. It
requires so much more responsibility than wind or solar seem to on the part of
plant operators.

------
ftr45
hope people will listen this obvious article , nuclear is cheaper, safer and
need less resource's than any other type of energy

[https://www.forbes.com/sites/jamesconca/2012/06/10/energys-d...](https://www.forbes.com/sites/jamesconca/2012/06/10/energys-
deathprint-a-price-always-paid/#658c4855709b)

[https://www.nextbigfuture.com/2018/09/frances-nuclear-
clean-...](https://www.nextbigfuture.com/2018/09/frances-nuclear-clean-energy-
is-over-three-times-faster-and-cheaper-than-germanys-solar-and-wind.html)

[https://www.oecd-nea.org/ndd/pubs/2015/7057-proj-costs-
elect...](https://www.oecd-nea.org/ndd/pubs/2015/7057-proj-costs-
electricity-2015.pdf#p60)

------
ekianjo
For folks who think solar/wind/other sources are just as good or better, why
not invest in all energy sources anyway? In most cases anyway this will be
private investment and there is no reason not to experiment with all types of
energies (including new types of nuclear reactors) instead of waiting and see
if renewables can achieve their promise.

If you are going to make bets, take as many bets as you can.

~~~
rorykoehler
People don't want to invest in nuclear


see the volatility of solar and wind be used as an
argument against baseline generation, as this has traditionally been an
argument against renewables.

~~~
pfdietz
It's an argument against renewables only when the renewables are expensive.
When renewables are cheap, then nuclear is placed in an impossible situation,
as nuclear either displaces the renewables when they ARE available (incurring
a large marginal cost), or only runs when they aren't (forcing nuclear's large
fixed costs to be amortized over much less output).

It's likely that a cost optimized grid will have little or no nuclear in it.

~~~
DennisP
Unless you do solar and mostly skip wind, in which case you can build enough
nuclear to run the nighttime load and solar for just the extra daytime load,
then you can run the nukes 24/7\. That minimizes both nuclear downtime and
storage requirements.

But if     pcoinsTip.reset();
        pcoinsdbview.reset();
        pblocktree.reset();
}

TestChain100Setup::TestChain100Setup() : TestingSetup(CBaseChainParams::REGTEST)
{
    // Generate a 100-block chain:
    coinbaseKey.MakeNewKey(true);
    CScript scriptPubKey = CScript() <<  ToByteVector(coinbaseKey.GetPubKey()) << OP_CHECKSIG;
    for (int i = 0; i < COINBASE_MATURITY; i++)
    {
        std::vector<CMutableTransaction> noTxns;
        CBlock b = CreateAndProcessBlock(noTxns, scriptPubKey);
        m_coinbase_txns.push_back(b.vtx[0]);
    }
}

//
// Create a new block with just given transactions, coinbase paying to
// scriptPubKey, and try to add it to the current chain.
//
CBlock
TestChain100Setup::CreateAndProcessBlock(const std::vector<CMutableTransaction>& txns, const CScript& scriptPubKey)
{
    const CChainParams&


Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.
Neural stem cells (NSCs) are regarded as a promising therapeutic approach to protecting and restoring damaged neurons in neurodegenerative diseases (NDs) such as Parkinson's disease and Alzheimer's disease (PD and AD, respectively). However, new research suggests that NSC differentiation is required to make this strategy effective. Several studies have demonstrated that melatonin increases mature neuronal markers, which reflects NSC differentiation into neurons. Nevertheless, the possible involvement of mitochondria in the effects of melatonin during NSC differentiation has not yet been fully established. We therefore tested the impact of melatonin on NSC proliferation and differentiation in an attempt to determine whether these actions depend on modulating mitochondrial activity. We measured proliferation and differentiation markers, mitochondrial structural and functionalbinding of the lectin *Lycopersicon Esculentum*, and to incorporate acetylated low-density lipoproteins labeled with 1,1'-dioctadecyl-3,3,3,3'-tetramethylindo-carbocyanine perchlorate (DiI-Ac-LDL). All studies were performed on cells from passages 3 to 7. Under these conditions, the cells sustained consistent functional, morphological, and phenotypic characteristics.

2.2. siRNA Transfection {#sec2dot2-cells-09-00416}
-----------------------

siRNA to c-Jun and c-Myc were obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA). siRNA to Foxo3a was synthesized by Integrated DNA Technology (IDT, Skokie, IL, USA) based on a reported sequence in the bovine cell genome. Three VVEC populations obtained from different animals were transfected with TF-specific siRNA (10 nM) containing three different pooled siRNA or universal siRNA (10 nM) (Sigma-Aldrich St. Louis, MO, USA), using Dharmafect Reagent® (Dharmacon, Denver, CO) as per manufacturer recommendations. Universal siRNA (scramble) was used as a control. Cell


lysates prepared from siRNA-treated cells were analyzed by Western blot to determine the efficacy of knockdown 48 h after transfection. The siRNA-mediated knockdown was in the range 70--80%. Cells in two 100 mm dishes were transfected with TF-specific siRNA and used for thymidine incorporation, migration, tube formation measurements, and WB analysis of angiogenesis-associated target proteins. The values of siRNA-treated cells were compared to scramble siRNA-treated cells from 3 different cell populations.

2.3. Preparation of Nuclear Fraction {#sec2dot3-cells-09-00416}
------------------------------------

Growth-arrested VVECs (72 h, DMEM without serum) were stimulated with ATP (100 μM) for 1, 6, and 12 h. At the end of the incubation, the cells were washed with ice-cold PBS, scraped off the dishes, and collected by centrifugation at 500 x g for 3 min at 4 °C. Nuclear extracts wereprepared using NE-PER^TM^ kit (Piers, Rockford, IL, USA). Nuclear fractions were snap-frozen in liquid nitrogen in aliquots and stored at --80 °C. Protein concentration was determined by the Bradford method using the Bio-Rad protein assay kit with bovine serum albumin as a standard.

2.4. Analysis of Transcription Factor Transactivation {#sec2dot4-cells-09-00416}
-----------------------------------------------------

Twenty micrograms of nuclear protein were processed according to TranSignal Protein/DNA Array I and Array II kits (Panomics, Inc., Redwood City, CA, USA) according to the manufacturer's instructions, without modifications. The National Institute of Health ImageJ program was used to determine the density of spots on the array. Data obtained were further analyzed using Morpheus ([www.broadinstitute.org](www.broadinstitute.org)) and Ingenuity Pathway Analysis Software (IPA Qiagen 2.2).

2.5. DNA Synthesis {#sec2dot5-cells-09-00416}
------------------

The cells were plated in 24-well plates in triplicates at a density of 1.2


5](#cells-09-00416-f005){ref-type="fig"}b). The KD of c-Jun attenuated serum-induced, but not ATP-induced migration. Foxo3a and c-Myc KD increased basal VVEC migration, suggesting that under serum-starved conditions the presence of these proteins may be inhibitory to angiogenesis.

In the Matrigel angiogenic assay, ATP- and serum-induced tube formation (average tube length) was inhibited by c-Jun KD, not by Foxo3a KD. C-Myc KD inhibited serum- but not ATP-induced tube formation. In addition, Foxo3a and c-Myc KD evidently increased tube formation under basal conditions. However, the effect did not reach statistical significance ([Figure 5](#cells-09-00416-f005){ref-type="fig"} c,d). Notably, c-Jun KD-mediated decreases in ATP- and serum-induced tube length were accompanied by an increased number of shorter tubes. This tendency was also observed in Foxo3a KD cells ([Figure 5](#cells-09-00416-f005){ref-type="fig"} c,d). Taken together, these data demonstrate that c-Jun is requiredsiRNA demonstrated that they control the activation of hypoxia-sensitive factors, including HIF-1α, HIF-2α, NFκB, and Smads, suggesting a functional cross-talk between angiogenesis-associated TFs in hypoxic and inflammatory conditions. Our data indicate that c-Jun predominantly regulates pro-angiogenic genes in VVECs. Previous studies showed that c-Jun expression positively correlates with the angiogenesis of normal and tumor blood vessels, and targeting c-Jun inhibits vascular permeability and inflammation \[[@B50-cells-09-00416],[@B65-cells-09-00416],[@B66-cells-09-00416],[@B67-cells-09-00416]\]. siRNA to c-Jun, c-Myc and, to a lesser extent, Foxo3a KD decreased levels of HIF-1α, suggesting the role of these TFs in HIF-1α stabilization under pro-angiogenic conditions in normoxia. Association of c-Jun with HIF-1α via its oxygen-dependent degradation (ODD) domain potentiates its transcriptional activity by preventing proteasome degradation. In addition, co-operation of HIF-1α and c-Jun increases VEGF and Il-8 expression and promotes angiogenesis


have been reported in differentiating lens epithelium, keratinocytes, skeletal myocytes, and in activated T cells. It can also be observed in certain tumors and predicts better chances of survival \[[@B83-cells-09-00416],[@B84-cells-09-00416],[@B85-cells-09-00416]\].

Our results suggest that c-Myc may have a dual role in angiogenic regulation by functioning as a transcriptional activator and repressor, maintaining the angiogenesis balance in physiological states. C-Myc ^Ser62^ phosphorylated by Akt may have a role in initiating angiogenesis. However, when Akt activity is low, c-Myc can be phosphorylated at Thr58 by GSK, which targets it for rapid proteolysis by the ubiquitin pathway, allowing the expression of c-Myc genes controlling vessel stabilization \[[@B86-cells-09-00416]\]. Akt, therefore, may play an important role in determining the role of c-Myc in regulating angiogenesis.

Transcriptional control of VV expansion and its contribution to pathological6, and 12 h were compared to time 0. The effect of PI-103 was determined individually at each indicated time point in control and ATP-treated cells; the data represent the mean ± SEM from three to four independent experiments (n = 3--4) conducted on three cell populations. \#*p* \< 0.05 for comparison between cont vs. ATP; \**p* \< 0.05 for comparison between control vs. PI-103 treatment (unpaired, two-tailed *t* test).](cells-09-00416-g004){#cells-09-00416-f004}

![Effect of siRNA-mediated knockdown of c-Jun, Foxo3a, and c-Myc on ATP-stimulated proliferation, migration, and tube formation of VVECs. Cells were transfected with scramble siRNA or siRNA to c-Jun, Foxo3 and c-Myc using Dharmafect Reagent® following the protocol suggested by the manufacturer (Dharmacon). Cells were stimulated with ATP (100 μM) or serum (1% FBS), and proliferation, migration, and tube formation


One of the videos was recorded in 2004, another one in 2013 and the newest one in 2014. In the videos, we see a UFO performing maneuvers, unlike anything mankind can create today, ignoring gravity and laws that govern over manmade vehicles. Both videos were analyzed by experts who agree that the objects in question are extraordinary and unlike anything they’ve ever seen. Some of these UFO’s were not visible to the naked eye and somehow managed to avoid being detected on radar.

In the 21st century, there are two types of people when alien life is discussed. Those who firmly believe we are being visited –and have been visited for thousands of years— and those who believe that UFO sightings are entirely a man-made phenomenon.

In an interview with“two thermal spotlights like discharges that did not coincide with the axel of motion.” The technician described it as “white with a semi-oval shape on the horizontal axis.”

Furthermore, reports state that the pilot tried numerous times to communicate with the UFO, using the multinational, civilian bandwidth designed specifically for his purpose.

He received NO reply. Simply put, unbelievable.

Videos like these are precisely what is needed for society to understand that there are some things out there that conventional explanations do not satisfy.

Another equally amazing sighting was recorded on March 05, 2004, when the Mexican Air Force witnessed 11 flying objects flying along side of them during an air patrol of a drug smuggling.

Strangely, the unidentified flying objects were only visible through the military plane’s IR-system (infrared), and could not