     .HasColumnType("int");

                    b.Property<string>("TypeLine")
                        .HasColumnType("nvarchar(max)");

                    b.Property<string>("Variant")
                        .HasColumnType("nvarchar(max)");

                    b.HasKey("Id");

              packets are serialized structs with uniq fingerprints for each uniq
// combination of data types, lookup of correct layer type is based on that
// fingerprint.
func (lcm LCM) NextLayerType() gopacket.LayerType {
	if !lcm.Fragmented || (lcm.Fragmented && lcm.FragmentNumber == 0) {
		return GetLCMLayerType(lcm.fingerprint)
	}

	return gopacket.LayerTypeFragment
}

// LayerType returns LayerTypeLCM
func (lcm LCM) LayerType() gopacket.LayerType {
	return LayerTypeLCM
}

// LayerContents returns the contents of the LCM header.
func (lcm LCM) LayerContents() []byte {
	return lcm.contents
}

// LayerPayload returns the payload following this LCM header.
func (lcm LCM) LayerPayload() []byte {
	return lcm.payload
}

// Payload returns the payload following this LCM header.
func (lcm LCM) Payload() []byte {
	return lcm.LayerPayload()
}

// Fingerprint returns the LCM fingerprint of the underlying message.
func (lcm LCM) Fingerprint() LCMFingerprint {
	return lcm.fingerprint
}


two-day festival. It is, simply put, a well-oiled machine.

It’s a familiar scene among a sea of change. That’s because the nonprofit Hawai‘i United Okinawa Association relocated the festival from its longtime home at Kapi‘olani Park to the Hawai‘i Convention Center last year. The bold move—no other ethnic festival had done it before—drew skepticism from its own members.

The Okinawan Festival is one of many ethnic celebrations that must adapt. Planning these large- and small-scale events—from managing budgets to recruiting workers to booking venues—is an ongoing challenge. In the past two years, the Okinawan and Prince Lot Hula festivals switched locations, Night in Chinatown and the Korean Festival were canceled and Festa Italiana made its debut. Despite the change, these volunteer-driven events continue to persevere and innovate. And that’s justfingers for emphasis. She’s always prepared, lugging around a cart filled with folders, binders, a laptop and a laser pointer. A delicate mixture of funny and pointed, she often cracks jokes, many at her own expense, to lighten the mood. But she never clamors for the spotlight, often dodging pictures and joking that she’s in the festival’s “witness protection” program.

At an August orientation at the convention center, the head of security asks her how long her group would hold lost and found items. She replies with a straight face, “until we can sell it,” eliciting chuckles from the audience.

But trying times can get to anyone, even the otherwise cool, calm and collected Ige. Surrounded by the hustle and bustle of volunteers and staff sprinkled throughout the convention center,


the “amazing feeling of accomplishment” after the groundbreaking event in 2017. He hopes to expand the event to a week of festivities and recruit more people to help with planning.

“The board needed a new bolt of energy,” says Nick Gambino, one of Festa Italiana’s core volunteers. “My dad was on the board for a while, and that was the older generation. But since Zach got this event going, it made me really excited to share the Italian culture. Hopefully this becomes a thing that will go on in the future.”

The Volunteers

These fearless volunteers led with humility, passion and a sense of humor.

Zach DiIonno

Photo: David Croxford

“We took on something that was really hard. It was such an amazing feeling of accomplishment.”

Festa Italiana event director, 35, small-business owner

Jo Ige

Photo: DavidNow that the “Crisis on Earth-X” has been averted (somewhat), it’s time to refocus our concerns on the immediate dangers threatening the superheroes of The CW. Let’s begin in National City, shall we? READ MORE

Mon-El finally re-enters Supergirl‘s orbit on Monday (The CW, 8/7c), but before you get too excited, you might want to heed this warning from star Melissa Benoist: “It won’t be the reunion you expect.” READ MORE


 </dependency>

        <!-- Import the Bean Validation, we use provided scope as the API is included in EAP -->
        <dependency>
            <groupId>jakarta.validation</groupId>
            <artifactId>jakarta.validation-api</artifactId>
            <scope>provided</scope>
        </dependency>

        <!-- Needed for running tests (you may also use TestNG) -->
        <dependency>
            <groupId>junit</groupId>
            <artifactId>junit</artifactId>
modes containing quanta with energy $\Omega_i$. Therefore, ambiguities as they may appear in the definition of the thermodynamic entropy do not appear in the following calculation, which follows the notation of Yurtsever but corrects an erroneous assumption that was made in [@Yurtsever].

Yurtsever constructs the dimension $W(B)$ of the constrained Fock space according to $$W(B)=1+N+\sum \limits_{n=1}^{N} \frac{S_n}{n!}, \quad
N=\frac{L^3}{2 \pi^2 c^3} \int \limits_{0}^{2 \pi \mu / \tau_p} \omega^2 d \omega
=\frac{4 \pi \mu^3}{3} \Biggl( \frac{L}{l_p} \Biggr)^3,
\label{toobigsum}$$ where $N$ is the total number of modes with a quantal energy smaller than $2 \pi \mu \hbar/\tau_p$ (eq. (3) in [@Yurtsever]). We point out again what the meaning of the terms $S_n/n!$ actually is. $S_1$ is the dimension of the subspace where exactly one but arbitrary mode is excited. In order not to violate


dimensions (which are [*irrelevant*]{} concerning their contribution to the full $W(B)$ according to Yurtsever, but which generate the much smaller true entropy à la ’t Hooft).

In this paper, an example was presented where [*only*]{} lowest lying states of the scalar field are occupied in order to show that it is indeed [*impossible to find points*]{} on subpolyhedra with dimension $> \tilde{N}$, without violating the Black hole energy bound.

Conclusions
===========

The derivation of a holographic entropy bound by counting states of a system of free scalar bosons enclosed within a spatially bounded region in flat spacetime presented in [@Yurtsever] and generalized *bona fide* in [@Aste] to arbitrary spacetime dimensions is flawed by a mathematical error. It should also be pointed out that the correct $A^{\frac{3}{4}}$ result for the entropy has beenthe adhesion of the conidia to plant surface during germination ([@B45]). A glucan β-1,3-glucosidase, a β-1,3-endoglucanase, and an exo-β-1,3-glucanase were secreted early in *B. cinerea* development ([@B16]). The same β-1,3-endoglucanase and other glucanases were detected in the *B. cinerea* interaction with tomato ([@B43]). The degradation of β-1,3-glucans may contribute to activating the induction of the programmed cell death in plant cells by generating elicitors in the form of β-(1,3)(1,6)-oligomers ([@B16]).

Cell Wall-degrading Enzymes
---------------------------

*Botrytis cinerea* is provided with a set of CWDEs able to degrade the cell wall to allow plant tissue colonization to get nutrients ([@B37]; [@B42]; [@B25]). Despite having a broad spectrum of host plant species, this fungus has predilection for dicotyledonous plants with cell walls rich in pectin, which usually is highly methyl-esterified, in order to protect


in *B. cinerea* ([@B35]), and in the related necrotrophic fungus *Sclerotinia sclerotiorum* ([@B32]). Its physiological roles in pathogenesis include: (i) the enhancing of PG activity to promote cell wall degradation, (ii) suppression of the plant oxidative burst, (iii) the plant-protection enzymes inhibition, (iv) involvement in the pH signaling, (v) deregulation of stomatal guard cell closure, (vi) induction of apoptosis-like cell death, and (vii) alteration of the cellular redox status in the plant ([@B4]). Oxalic acid secretion makes an optimal acidic environment for the pathogenicity factor expression and secretion in *B. cinerea*, such as CWDEs ([@B36]), peptidases ([@B47]), and for the phytotoxin biosynthesis ([@B14]). Oxaloacetate is the precursor of oxalic acid. The malate dehydrogenase (MDH) catalyzes the reversible conversion of oxaloacetate and malate. A low-gene expression levels of fungaltheir speed and not financial gain.

Given the choice - Petrov or Nico on equal terms - who would you choose if you were Renault or Williams ? No question - but this is Formula 1 in 2011. Absent the re-entry of the OE auto manufacturers (and their resources), this is the future. Thank Max Mosely's governance for this state of affairs. It took years, but job done.

On a less horribly subjective note: the manufacturers didn't leave because of Mosley. They left because of the financial crisis and the huge costs. Now I'm no fan of Mosley but he was right in saying costs had to go down. Of course the RRA is a better method than a limit on total expenditure (better as in that it has a


Europe and then to Asia then South America and then Asia followed by the Middl East is a long way and a lot of expense to move all the extra bits and piece required for it.

And finally, while many teams don't have a link to a GP2 team, and I think that is mostly a good thing (it means that the drivers are trying to prove themselves rather than have good stats and rely on simulator work).

GP2 2011 teams.

DAMS - link with Renault in the past

Lotus ART - link with Group Lotus and hence Renault now

Arden - created by Horner, uses/d Red Bull Livery

Ferrari will never be assosiated with anything below them

McLaren like Redbull has it's own driver program

Carlin used to have links with Williams I believe

Ricciardo isyet to try GP2. Bianchi has only had 1 season in GP2. Senna is in F1 but wasd with a horrible team who gave him worse cars than his teammate and pretty much had a hidden war with him all year despite being contracted before the team became HRT. Hulkenberg is good enough for F1.

GP2 is a base training ground and in an age of ctting down expenses and what not I don't believe that creating more is good at all. Seeing young guns in Friday practice session would be good. Maybe a short race (45 mins say) running opposite of F1 WCC order for test drivers each sunday morning. Would be good to see, wouldn't be a real comp and the cars and such are there, but


car can actually be sued for several season, that could be a very good thing.

Currently each car is an evolution while some are completely redesigned. If the 2011 car was to be used until 2018, with only minor changes each year then while it may be spread out in 2011 and maybe 2012, by 2013 the extra money RBR has over Sauber would only mean a tenth or so rather than half a second or so.

2009 was a complete design of the entire car

2010 increase of weight (and hence weight has to be redistributed again and made into the chassis) and new front tyres

2011 has new tyres, new changing wings, weight distribution changing again

2012 will no doubt herald several major changes

2013 has a new engine

And that is onlyof their kids picking up the sports and gaining fame etc.

Motorsports has limited following as compared to ones I mentioned above. So wooing sponsors either by Bernie or by teams has inherent limitations.

Unless of course Bernie and teams are ready to have races on Prime-Time television 2-3 times a week without making it boring to audience and managing logistics Sponsors don't have sufficient ROI on their investment.

Turn on the Tele and you will find some team playing other some ball game form or other. That is not the case with motorsports.

Marketing wise Nascar has better understanding of the importance TV Money and have a bigger calendar (almost twice the number of races) and logistically they have kept themselves limited to America so have better control on logistical variables.

Even


article, but the 50 million pound question, what would you advise Nico to do?

As a Force India fan (and lets face it not many people are, although it stems from my Damon Hill days and Jordan, and vowing to support his last team when he left, and yes, the Spyker years were painful to watch), I can't help feeling Nico would be a very strong partnership with Adrian, but Paul di Resta I feel has earned his spurs (so very catch 22). I do love the fact we have Mercedes power though, and supporting Nico would go a long way to supporting that relationship. I must admit, I love Adrian, and want him in the team, but for all his years of service and improvement, I think hewith published data [@pone.0023462-Fitzpatrick1]. Women with shorter telomere length had a slightly higher BMI; this was significant after adjusting for age (P = 0.03). Women with shorter telomere length were more likely to smoke, but this was not statistically significant (P = 0.07). There was no significant association between menopausal status and telomere length.

10.1371/journal.pone.0023462.t001

###### Characteristics of women by quintiles of telomere length.

![](pone.0023462.t001){#pone-0023462-t001-1}


Experimental and clinical pharmacokinetics of amitryptiline: comparative analysis.
Pharmacokinetics of two amitriptyline tablets, Amitryptiline Nycomed and Amitryptiline, was investigated clinically and experimentally after a single oral dose of 50 mg. A statistically significant correlation between amitryptiline serum concentrations in dogs and healthy humans (r=0.683, p<0.006) was established. In humans, standartized values of peak concentration and area under the concentration curve were significantly higher, specific volume of distribution and total clearance were lower, and half-life and mean retention time were significantly higher than in dogs. Characteristics of apparent bioavailability in dogs and healthy people did not statistically differ.Q:

python - request url as mobile

I'm trying to send GET request to some urls with User-Agent as mobile to get the the redirected url (for example - http://m.google.com instead of http://google.com).
I've tried requests library and urllib2 too - it seems that the User-Agent isn't sent with the request. Also read another questions here but the answers was not clear enough - if its just buggy or I miss something?
This is my code:
try:
    req = requests.get(item.url, headers={'User-Agent': 'Mozilla/5.0 (iPhone; CPU iPhone OS 9_1 like Mac OS X) AppleWebKit/601.1.46 (KHTML, like Gecko) Version/9.0 Mobile/13B137 Safari/601.1'}, timeout=5)

except requests.exceptions.HTTPError:
    continue

except requests.exceptions.Timeout:
    continue

print (item.url + ' => ' + req.url + ' (' + str(req.status_code) + ')')

Still, always get the computer version instead of


changes

The shemozzle on April 14 at AAMI Park led to big changes surrounding full-time and half-time sirens. Time keepers wear the communication vest that referees and touch judges have so they can deliver the countdown to the on-field officials. The problem with the fellow who pushes the button also doing his Houston Mission Control impersonation is that when he is talking to the refs, he is not pushing the button. This led to confusion last Monday that Penrith claimed cost them a field goal on half time against Gold Coast. A memo went around last week instructing time keepers not to say “zero” to the referees. It’s “five, four, three, two, one” and hit that button.

6. A Lion in the sand

AS usual, there will be an International Federationour fight against organised criminals continues and I urge anyone with any information about suspected drug related activity in their community to get in touch. You will be listened to and we will investigate the matter.

“You can report suspected drug dealing to us directly by calling 101. Alternatively information can also be given anonymously, via Crimestoppers, on 0800 555 111.”


points_float(num_points);
  for (int i = 0; i < num_points; ++i) {
    std::array<float, 2> pos;
    // Generate some pseudo-random points.
    pos[0] = static_cast<float>(8 * ((i * 7) % 127) + 1) / 2.5f;
    pos[1] = static_cast<float>(13 * ((i * 3) % 321) + 1) / 3.2f;
    points_float[i] = pos;
  }

  PointCloudBuilder builder;
  builder.Start(num_points);
  const int att_id3 =
      builder.AddAttribute(GeometryAttribute::POSITION, 3, DT_UINT32);
  for (PointIndex i(0); i < num_points; ++i) {
    builder.SetAttributeValueForPoint(att_id3, PointIndex(i),
                              patient's oxygen saturation 164, a numerical readout of pulse rate 166, and a display the patient's plethysmograph 168, which provides a visual display of the patient's pulse contour and pulse rate. The monitor 160 has a sensor port 162 that transmits emitter drive signals to the sensor 110 and receives the detector intensity signals from the sensor 110. The patient cable 140 provides the electrical and mechanical connection and communications link between the sensor port 162 and the sensor 110. The patient cable 140 has a sensor connector 142 that connects to the patient cable connector 114 and a monitor connector 144 that connects to the sensor port 162.


that there are some additional challenges in the Lake Chad Basin Area.

So, approximately 80 percent of our theater security cooperation activities are going to be focused in Niger, Nigeria, Chad and Cameroon area for next year. That is a significant increase from what we had over the past year itself. Those, I would say, are our focus areas, if you will — the Lake Chad Basin area, and the different exercise hosting nations as well.

Q. Why is the Lake Chad Basin such an important area?

A. There are a number of focus areas, really — reasons, I should say — that we are looking at the Lake Chad Basin. One is what is happening to Lake Chad. We are seeing, right now, Lake Chad is about 10 percent ofmum-of-two Muzoka, 27, pleaded guilty to fraud by false representation in relation to their holiday in 2015.

Adjourning the case District Judge Taffe said it appeared the matter had "crossed" the custody threshold and he would be considering a jail sentence.

Leon Roberts tucks into a meal on holiday in TurkeyCredit:
Eugene Henderson

He added: "That is in the forefront of my mind, it would be flying in the face of common sense to think this is an isolated incident.

"This offence is outside the [sentencing] guidelines because it encourages a tsunami of false claims.

"All options are open at this stage and this is a serious case and it may be that a custodial sentence will follow to show the importance of your wrongdoing."

Jade Muzoka could now face jail alongside her former partnerCredit:
Eugene


free ends spaced apart in the reservoir. The washer fluid shorts the electrodes when the fluid level is above the electrodes and the electrode ends are completely immersed in the washer fluid. When the electrodes are clear of fluid, an open circuit exists between the electrodes which can be detected by circuitry coupled to the electrodes to generate the low fluid level signal.
Such a sensor design is simpler in construction than the separate tubular column sensor, but is still separately mounted in the reservoir from the washer fluid pump.
The windshield washer fluid pump is typically mounted in a housing adjacent to the fluid reservoir and coupled to a discharge outlet on the reservoir. Typically, a multiple-part housing is used to couple the reservoir discharge outlet to a fluiddon’t hit him very well either. They hit him at a .224 clip.

It’s sort of a 4 year deal – the vesting options are not difficult to meet. Let’s give Jimmy 350 ABs before we start to write him off. It just looks like a slow start to me. The problem is that when you are 33, people see a slow start as the beginning of the end. Sometimes it is and sometimes it isn’t. Jeter had a terrible start a few years ago and he’s doing fine. The same thing happened to Dunn last year (his whole year was bad) and Ortiz the year before. And don’t forget Furcal, who looked cooked last year and has done nothing but hit since arriving in St. Louis. I’m not


saying Jimmy is still an MVP candidate, but I doubt we’ve seen the end of him.

He’s hitting what now — .224 going into today’s game, where he got no hits and another two Ks? Now 5 BBs and 38 Ks. For the year-to-date, it’s the same crappy numbers he’s always put up. Everyone is the next Mickey Mantle if you are allowed to extrapolate from cherry-picked dozen game intervals. He has these couple-week-long good streaks every season and then regresses to crap. I know it’s tempting to say that if he can perform well for a dozen games in a row, then he has the ability to perform well and just needs to develop consistency, but he just hasn’t ever been able to do that for more thancast members around to react to that emoting?

LM: It’s great because the crew is reacting. I can hear the crew laughing a little bit, so that’s always validating. But it’s great because when you want to try stuff out, you still have to be generous to your fellow actors. “I’m going to goof around for awhile and you guys don’t want to sit around and watch this all day—so you guys don’t have to watch it.” And if they leave, the pressure’s off, too. It’s like, “Oh, well they’re not here. So I can get silly whenever I feel like it.”

The benefit of that is if you look at Jake Johnson a certain way, he’ll make you laugh hysterically. Because whether he’s off camera or not, he reacts


Introduction {#S1}
============

HLA-G is a non-classical HLA class I molecule. It is a potent suppressive molecule that impairs effector functions of immune cells belonging to the innate and adaptive immune system. Under physiological conditions, its surface expression is restricted to the maternal--fetal interface and to immune privileged adult tissues ([@B1]). However, secreted soluble forms of HLA-G are detectable in a variety of body fluids such as peripheral blood and amniotic fluids ([@B2]), malignant ascites ([@B3], [@B4]), pleural effusions ([@B5]), cerebrospinal fluid ([@B6], [@B7]), and sperm ([@B8]). Neo-ectopic or aberrant expression of HLA-G has frequently been related to malignancies ([@B9]--[@B13]), viral infections ([@B14]--[@B19]) including liver-related hepatitis B ([@B16]) and C ([@B18]) virus infections, autoimmune disorders ([@B20]--[@B22]), inflammatory diseases ([@B23]), complications ([@B24], [@B25]), and transplantation outcomes ([@B26], [@B27]).

A unique feature ofimmune activating or immune suppression, introducing homeostasis or immune tolerance by the induction of T cell apoptosis, impairment of DC maturation, or the prevention of NK and T cell cytotoxicity ([@B68]--[@B76]). Furthermore, the molecular transfer of miRNA by EVs can alter the expression profile of the recipient cell ([@B71]). Tumor-derived EVs can stimulate immune suppression and tumor progression in different ways including the inhibition of tumor-specific T cell function and proliferation ([@B77]), the promotion of regulatory T cells subsets ([@B78]), and transfer of oncogenic receptors ([@B61]).

The Current Status and Open Questions of HLA-G-Bearing Extracellular Vesicles {#S3}
=============================================================================

HLA-G-Bearing EVs and Cancer {#S3-1}
----------------------------

Without any doubt, the neo-ectopic expression of HLA-G molecules either on the surface of tumor cells or released as soluble forms can be considered a critical factor for cancer


progression. Albeit high blood levels of soluble forms of HLA-G have concordantly been related to cancer, the prognostic relevance of soluble HLA-G in the blood has not always been established as an independent marker in terms of disease progression and survival ([@B39]). To date, the source of soluble HLA-G is known. In addition, it is not clarified whether HLA-G-bearing EVs or free soluble HLA-G (sHLA-G~free~) are produced by tumor cells and whether both subcomponents contribute to immune evasion of tumor cells.

Secreted HLA-G-expressing EVs (Table [1](#T1){ref-type="table"}) have been detected for the first time in supernatants of a melanoma cell line, originated from a HLA-G-positive melanoma lesion ([@B32]). Both, the cell line cells and the secreted EVs express the full-length isoform HLA-G1. Up to now, it is not known whether  Immunomodulation by synergistic additive effect of HLA-G, IL-10, and TGFβ                          Potential therapeutic option for patients with therapy--refractory GvHD using MSC-derived
HLA-G-bearing EVs   ([@B91])

The first *in vivo* existence of HLA-G-bearing EVs was reported for ascites and pleural exudates derived from cancer patients ([@B53]). The EV fractions, however, contain ubiquitinated HLA-G molecules with atypically high HLA-G molecular sizes ranging from 50 to 75 kD. Generally, ubiquitination is a frequent posttranslational protein modification, by which proteins are targeted to protein degradation or directed to other cellular locations ([@B79], [@B80]). Interestingly, EVs contain many polyubiquitinated proteins, which are not integrated into their membrane ([@B81]).


Thus, the presence of secreted HLA-G5 or HLA-G6 cannot be excluded.

Very recently, we established the prognostic relevance of HLA-G-bearing EVs for neoadjuvant chemotherapy-treated (NACT) breast cancer patients for the first time ([@B82]). Both, the total amount of HLA-G~tot~ and the amount of sHLA-G~free~ were significantly increased in breast cancer patients. Before NACT, sHLA-G~free~ levels are exclusively related to estrogen receptor expression, whereas high amounts of HLA-G in EVs (sHLA-G~EV~) enriched from peripheral blood samples are associated with the existence of circulating stem cell-like tumor cells. Strikingly, despite high amounts of sHLA-G~tot~, its prognostic relevance could not be substantiated. However, different impacts on prognosis have been shown for the two subcomponents sHLA-G~EV~ and sHLA-G~free~: high sHLA-G~EV~ levels are associated with disease progression, whereas high sHLA-G~free~ levels are related to                                      \end{array}\right).
    \end{aligned}$$ So in a formal sense, we can mathematically reduce treatment of $s(x,y)+q(x)+r(y)$ to that of symmetric quadratic forms, applying then the many ideas for such functions; for example, McCormick convexification, convex relaxation via semidefinite programming (and further quadratic and linear relaxation) together with disjunctive cuts (see [@SBL2008], [@MIQCP] and [@MIQCPproj]), and d.c. programming (see [@MR3685193]). Following this way of thinking though, we can go the other way around. That is, given a symmetric quadratic form $z'Tz$, with symmetric $T\in \mathbb{R}^{p \times p}$, we might seek


                                          \end{array}\right),
    \end{aligned}$$ but then we are dealing with an order $m+n$ matrix. If our context really is in handling $s(x,y)+q(x)+r(y)$, and we are willing to deal with order $m+n$ symmetric matrices, we might as well then symmetrize all at once via .

Treating bilinear forms by emulating Saxena et al. {#sec:Saxena2}
--------------------------------------------------

Next, we extend the idea of Saxena et al. to bilinear forms.

A violation of means that there is a non-zero singular-value $\sigma$ in $\Sigma$. So, for the associated columns $u$ of $U$ and $v$the concave $-q_i^2$ terms, which requires first calculating lower and upper bounds on the $q_i$. Note that we can either derive bounds on the $q_i$ from the box constraints on $x$ and $y$, or we can get potentially better bounds by solving further (convex) optimization problems.

Note that if we *simultaneously* treat the two concave terms ($-q_i^2$) via the disjunctive technique of Saxena et al., we are led to a 4-way disjunction.

Treating bilinear forms with McCormick {#sec:McInstead}
--------------------------------------

Another possible way of relaxing is to apply McCormick convexification. Let $$\label{defining}
\left\{
\begin{array}{l}
s:=\left \langle uv', W \right \rangle ~,\\
p_1:=u'x~,\\
p_2:=v'y~.\\
\end{array}
\right.$$ We first calculate bounds $[a_i,b_i]$, for $p_i$ ($i=1,2$). Then we carry out the associated McCormick relaxation of $s=p_1p_2$: $$\begin{aligned}
        & s\leq b_2 p_1 + a_1 p_2 - a_1


the other hand, we observed that for the great majority of instances, the algorithm stopped only at the time limit, showing that all cuts generated were effective to cut off the current solution of the relaxation. Finally, we see that when a large number of cuts is added, as for the smallest instances, the reduction in the duality gap is significant.

Further analysis
================

Saxena et al.’s disjunctive cuts: bilinear vs. symmetric approach
-----------------------------------------------------------------

In this section, we present a comparative analysis between the non-convex valid inequalities that generate Saxena et al.’s disjunctive cuts, considering both approaches discussed in this paper: the standard symmetric approach, where we use the symmetrization in , and the alternative bilinear approach presented in §\[sec:Saxena2\]. The idea is to compare the strength of the inequalities, when derived fromproducts

The cua gene-cluster from loci Ccel_2109 to Ccel_2115 encompasses seven genes predicted to encode (i) a solute binding protein (CuaD), (ii) a putative two-component system composed of a sensor (CuaS) and a response regulator (CuaR), (iii) a solute binding protein CuaA and two integral membrane proteins CuaB and C, forming a putative ABC transporter, and (iv) a putative GH94 cellobiose phosphorylase named CbpA in the present study (Fig. 1).

Fig. 1

The cua gene cluster and its neighboring genes. The genes encoding the putative three-component system are represented in black (cuaDSR), the ABC transporter in dark gray (cuaABC), and the putative cellobiose phosphorylase in gray (cbpA). Sizes (in bp) of intergenic sequences are indicated above. The surrounding genes are shown in white. Putative function of the gene products is indicated


binding abilities of the SBPs and characterized the activity of the putative phosphorylase towards cellodextrins. Three recombinant proteins, rCbpA, rCuaA, and rCuaD, were overproduced in E. coli and purified. Activity and specificity of rCbpA was analyzed on cellobiose and longer cellodextrins by quantifying both the released products including α-d-glucose-1-phosphate, and the consumption of the substrate. The enzyme displays phosphorolytic activity on cellobiose (G2) specifically, with KM and kcat values of 2.85 ± 0.47 mM and 1458.4 ± 108 min−1, respectively, but no activity was detected on longer cellodextrins (G3–G5).

The ability of rCuaD and rCuaA to bind to cellodextrins was analyzed using IsoThermal microCalorimetry (ITC). Both SBPs failed to bind to glucose and arabinose. rCuaA was shown to bind to all tested cellodextrins (G2–G5) (Table 1). In all cases,maltose ABC transporter in E. coli [22].

Fig. 2

Transcriptional intergenic links in the cua cluster. a Genetic organization of cua cluster with localization of promoters (arrow) and terminators (stem-loop) predicted by BPROM and FindTerm softwares. b RT-PCR analysis of cua gene cluster. PCR amplification was performed on genomic DNA (upper lane) or cDNA (lower lane) obtained after reverse transcription from a cellobiose grown culture. The primers used to study the transcriptional links between two successive genes were localized at the end of the first gene for the direct primer and at the beginning of the second gene for the reverse primer. Genes are named using their locus-tag number except for the control rpoD. The negative control (C) corresponds to a PCR performed on cDNA using primers targeting an intergenic


where the large intergenic region (735 bp) naturally occurring between cuaC and cbpA was shortened to 30 bp, including a ribosome binding site to secure the expression of cbpA into the operonic structure.

Western blot analyses confirmed the presence of CuaA in the mutant strains transformed with either pSOScuaABC or pSOScuaABC-cbpA (Fig. 7a). On arabinose, the growth of the transformed R. cellulolyticum mutant strains was not affected by the presence of the vectors compared to the wild-type strain (see Additional file 5). As expected on cellobiose, the mutant strain containing the control vector failed to grow, but complementation with the vector pSOScuaABC-cbpA restored the growth although with a longer generation time (18 h) compared to the wild-type strain. The growth of the mutant strain complemented with the vector carrying(at loci Ccel_1439, Ccel_2354, Ccel_3412), or β-glucosidases GH1 (Ccel_1139 and Ccel_0374) could be involved in this process [4, 35].

Fig. 8

Model for cellodextrins utilization by R. cellulolyticum. The cellulosome is depicted in light (CipC)/dark (enzymes) brown, bound to cellulose chains, and releasing cellodextrins like cellobiose. The latter is recognized by CuaD (orange) bound to CuaS (purple) and signal is transmitted to the regulator CuaR (light blue) which subsequently induces the expression of the genes cuaABC and cbpA. The ABC transporter captures a large range of cellodextrins from the environment and transport them in the cytoplasm where the cellobiose phosphorylase CbpA cleaves the cellobiose in glucose and G1-P. Other cellodextrins might be degraded by other unknown cellodextrin phosphorylases or β-glucosidase. Unknown proteins like NBD and enzymes degrading intracellular dextrins are


seems well adapted to anaerobic degradation of cellulose in R. cellulolyticum by scavenging efficiently cellodextrins present at low concentrations during the degradation of cellulose, reducing feed-back inhibition of the cellulases, and ensuring a requisite flow of substrate into the cell able to support phosphorolysis reaction. It is therefore not surprising that similar gene clusters are found in other anaerobic and cellulolytic bacteria whose genome was sequenced (Fig. 9). Recently, to produce cellulosic biofuel, synthetic biology strategies aimed to make yeasts and E. coli strains able to use cellobiose rather than glucose [38]. This was done through the acquisition of intracellular β-glucosidase, cellobiose phosphorylase, and/or cellobiose transporters from heterologous organisms [37–40], but none of the selected transporters used were ABC transporters. The efficient and energy-saving system of the conjugatedgrowth, samples of culture were harvested and centrifuged. The cellulose pellets and the soluble sugars present in the supernatants were analyzed using high-pressure anion exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD). After centrifugation, the pellets of the different growth samples were resuspended in 500 μL of 12 M H2SO4 and incubated for 1 h at 37 °C under shaking. For each sample, 20 µL was diluted into 220 μL of distilled water and autoclaved for 1 h at 120 °C. After cooling down, 50 μL of 10 M NaOH was added and the sample was centrifuged at 10,000g for 10 min at room temperature. 10 µL of supernatant was mixed with 190 μL of distilled water and 50 μL of 0.5 M NaOH. Glucose was quantified by


NarI and ligated in the NarI-digested pSOScuaABC. This construction brings cbpA downstream of cuaABC under the control of the same promotor, but it removes the intergenic region found naturally upstream of cbpA. The resulting vectors were called pSOSzeroTm, pSOSABC, pSOSABC-cbpA, and pSOScbpA, and were transferred in the MTLcuaD mutant strain as previously described [43, 44].

RNA preparation and reverse transcription

Ruminiclostridum cellulolyticum was grown in minimal medium supplemented with arabinose (2 g L−1), cellobiose (2 g L−1), or cellulose (5 g L−1). Samples were harvested at mid or late-exponential phase of growth (8000 g 10 min) and frost at − 80 °C. Total RNAs were isolated from the pellet using the Maxwell® 16 LEV simplyRNA Blood Kit (Promega) according to the manufacturer’s instructions and an extra TURBO DNase digestion stepconcentration of each primer was 0.5 μM. The cycling parameters of the qPCR were 98 °C for 2 min, followed by 45 cycles of 98 °C for 5 s, 56 °C for 10 s, 72 °C for 1 s. A final melting curve from 65 to 95 °C is added to determine the specificity of the amplification. To determine the amplification kinetics of each product, the fluorescence derived from the incorporation of EvaGreen into the double-stranded PCR products was measured at the end of each cycle using the SsoFast EvaGreen Supermix 2X Kit (Bio-Rad, France). The results were analyzed using Bio-Rad CFX Manager software, version 3.0 (Bio-Rad, France). For each point, a technical duplicate was performed. The amplification efficiencies for each primer pairs comprised between 80 and 100%.

Fluorescence


measurements

The gene cuaR was amplified by PCR using the forward and the reverse primers pBadRegFLEcoD and pBadRegPstR, and the amplicon was digested by EcoRI and PstI before ligation with EcoRI-PstI linearized pBAD24 [46] to give pBAD-cuaR. Intergenic regions (IG) located upstream of the genes at the locus Ccel_2116, cuaD, cuaA, and cbpA were amplified using forward and reverse primers pairs IG1gfpXhoD/IG1gfpBamR, IG2gfpXhoD/IG2gfpBamR, IG3gfpXhoD/IG3gfpBamR, IG4gfpXhoD/IG4gfpBamR respectively. Amplicons were digested using XhoI and BamHI, and ligated to linearized pUA66 vector allowing transcriptional fusions with gfpmut2 gene (see Additional file 8) [47]. The vectors pBAD24, pBAD24cuaR, and pUA66, pUA66-IG1, pUA66-IG2, pUA66-IG3, and pUA66-IG4 were transferred in MG1665 E. coli strain for fluorescence measurements. Recombinant MG1655 E. coli cells containing a pBAD24 and a pUA66 derivative vector were grown overnight in minimalStrictOrder A R, Proper _ (eqA==>eqA==>iff) R) :
  PartialOrder eqA (relation_disjunction R eqA).
Proof.
intros. intros x y. compute. intuition.
elim (StrictOrder_Irreflexive x).
transitivity y; auto.
Qed.

Hint Extern 4 (StrictOrder (relation_conjunction _ _)) =>
  class_apply PartialOrder_StrictOrder : typeclass_instances.

Hint Extern 4 (PartialOrder _ (relation_disjunction _ _)) =>
  class_apply StrictOrder_PartialOrder : typeclass_instances.


changing its spatial orientation depending on the nature of the solvent. Such structural organization provides a high stability of DC components and a rapid penetration through cellular membranes (transmembrane transfer) and it also provides prophylactic antithrombotic action in the case of peroral application to animals, due to the blockade of vascular platelets (inhibition of platelet aggregation by prostacyclin analogue) and plasmic (inhibition of thrombin activity and blood plasma kallikrein) links of the hemostasis process. Destabilase fraction with MW 50 kD is a dimer of the destabilase complex. As a result of DC destruction (liposome), hirudin, prostacycline analogue and blood plasma kallikrein inhibitor are released.Reemployment Rights Act of
1994 (“USERRA”), 38 U.S.C. § 4301, et seq. Specifically,
Wilson alleged that the Department of Energy (“the
DOE”) improperly revoked his security clearance, and the
Department of the Navy (“the Navy”) improperly termi-
nated his employment thereafter. The Board rejected
Wilson’s claims, finding that it lacked the authority to
review adverse security clearance determinations and
that the Navy had not acted improperly in terminating
Wilson given the revoked clearance. Wilson v. Dep’t of the
Navy, 122 M.S.P.R. 585 (2015). For the following reasons,
we affirm.
                      BACKGROUND
       A. Clearance Revocation and Termination
     Wilson worked as a civilian Resource Analyst at the
Nuclear Propulsion Directorate at the


does not dispute those conclu-
sions.
    Additionally, because Wilson alleged that the Navy
violated his due process rights, the AJ examined whether
the Navy provided him the procedural protections of
5 U.S.C. § 7513(b): 30 days advance written notice, rea-
sonable time to answer, notification of the right of repre-
sentation by an attorney, and provision of a written
decision detailing the agency’s reasoning. Looking to the
record, the AJ found that the Navy proposed Wilson’s
removal in writing, gave him a reasonable time to re-
4                                            WILSON   v. NAVY

spond,MB
E: (exchange drive) 886 GB, no pagefile assigned
S: (data drive) 976 GB, no pagefile assigned
System is set to Kernel Dump mode currently, but I've found that it doesn't work either when set to generate minidumps.
The frustrating thing is that the system has generated crash dumps before. The last one was from April 11, 2011. But it doesn't generate any more.
Did I overlook a setting somewhere?
EDIT:
According to MS troubleshooting tips for BSODs (http://support.microsoft.com/kb/130536), see responses below.

The Memory.dmp file already exists and the option Overwrite Any Existing File (found in Control Panel System) is not selected. It is a good idea to leave this box checked and to move or copy the current Memory.dmp file.
Response: The option to 'Overwrite Any Existing File' is checked
The


Address by President Kennedy at The American University, Washington, D.C., June 10, 1963
[]
I have . . . chosen this time and this place to discuss a topic on which ignorance too often abounds and the truth is too rarely perceived-yet it is the most important topic on earth: world peace.

What kind of peace do I mean? What kind of peace do we seek? Not a Pax Americana enforced on the world by American weapons of war. Not the peace of the grave or the security of the slave. I am talking about genuine peace, the kind of peace that makes life on earth worth living, the kind that enables men and nations to grow and to hope and to build a better life for their children-not merely peacehouse and go up and down on the curves of the trunk pan. The template would have to be three dimensional. I think a template can easily be made after the wheel house is installed.

One of the previous photos showed part of the trunk hinge bracket removed. I left the upper part of the bracket where the torsional bars mount.

The convertible mechanism bracket was also removed. I broke the spot welds where I previously welded the two extra brackets and drilled out the spot welds on the B pillar. The spot welds give reference points so that the bracket can be later installed in the exact posistion it was removed.

The convertible rocker has a flange that is next to the floor pan. It has to be cut off.

I


---
abstract: 'The aim of this paper is to clarify the relation between three different approaches of theories with a minimal length scale: A modification of the Lorentz-group in the ’Deformed Special Relativity’, theories with a ’Generalized Uncertainty Principle’ and those with ’Modified Dispersion Relations’. It is shown that the first two are equivalent, how they can be translated into each other, and how the third can be obtained from them. An adequate theory with a minimal length scale requires all three features to be present.'
address: 'Department of Physics, University of California, Santa Barbara, CA 93106-9530, USA'
author:
- 'S. Hossenfelder'
title: 'Self-consistency in Theories with a Minimal Length'
---

The Role of the Planck Scale
============================

Gravity itself is inconsistent with physics at very short scales. The introduction of gravity into quantum field theory appears to[@Padmanabhan:1986hd; @Scardigli:1999jh], the holographic principle [@Ng:2004bt], a T-duality of the path-integral [@Padmanabhan:1996ap; @Smailagic:2003hm; @Fontanini:2005ik] and probably further more. For reviews, the interested reader is referred to [@Garay:1994en; @Ng:2003jk; @Hossenfelder:2004gj]. The listed points are cross-related in many ways. The examination of these similarities in the presently availably approaches is a promising way to increase our knowledge about the quantum nature of gravity.

Besides the various attempts to pin down the emergence of a finite resolution of spacetime, the inclusion of the minimal length into the theoretical framework of the Standard Model (SM) has been examined from different sides: The Generalized Uncertainty Principle (GUP), Deformed Special Relativity (DSR) and Modified Dispersion Relations (MDR). These theories are an effective description of the expected effects of quantum gravity and provide us with a


p}'),{\bf p'})$ in the low energy regime (rest frame or very red shifted), where $|E'|, |p'| \ll m_p$. In this limit, we will have no modifications = [**p’**]{} f = [Id]{} . We then obtain the function $f$ at all energies by boosting it into a new inertial system in which ${\bf p}$ takes an arbitrary value. Since this boost is known, we can define the relation $f$ for all ${\bf p}$ via f([**p**]{}) := ([Id]{}(\^[-1]{} [**p**]{} )) .

DSR,GUP $\leftrightarrow$ MDR
-----------------------------

Now that we have seen how GUP is equivalent to DSR, let us examine their relation to the MDR. From the previous arguments, it will be sufficient to examine the way the GUP and MDR do affect each other. From a simple counting of equations one can alreadythe mass-shell condition as $\omega(k)$. The total derivative with respect to $k$ yields \_( (f\^[-1]{})\_0 - (f\^[-1]{})\_1 ) = \_k ( (f\^[-1]{})\_0 - (f\^[-1]{})\_1 ) , \[VSL\] taken at the position ${\bf k} = (\omega(k), k)$. Therefore, the theory will leave the speed if light unmodified if $f$ fulfills the constraint (f\^[-1]{})\_0(x,x) - (f\^[-1]{})\_1(x,x) =0 , which expresses the invariance of the light-cone. Two useful classes of function that respect the constancy of the speed of light, and which are appealing because of their symmetry are f\^[-1]{}([**k**]{}) &=& [**k**]{}  g([**k**]{})   g(0) 1 \[vsl1\]\
f\^[-1]{}([**k**]{}) &=& (h(,k), h(k,)) h(0) x , \[vsl2\] and with otherwise arbitrary $g,h$. For these functions, the dispersion relation for vanishing rest mass is not modified as one sees directly by inserting them in Eq.(\[bmdr\])


          float c2_proj = (ax * (c2.p[j].x + c2.tx) + ay * (c2.p[j].y + c2.ty)) / (ax * ax + ay * ay);
            c2_min = min(c2_proj, c2_min);
            c2_max = max(c2_proj, c2_max);
        }

        //Return if the projections do not overlap
        if(!(c1_max >= c2_min && c1_min <= c2_max))
            ret = false; //return false;
    }
    return ret; //return true;
}

What am i doing~[spring-boot-1.2.3.RELEASE.jar:1.2.3.RELEASE]
    at org.springframework.boot.context.embedded.ServletContextInitializerBeans.<init>(ServletContextInitializerBeans.java:74) ~[spring-boot-1.2.3.RELEASE.jar:1.2.3.RELEASE]
    at org.springframework.boot.context.embedded.EmbeddedWebApplicationContext.getServletContextInitializerBeans(EmbeddedWebApplicationContext.java:234) [spring-boot-1.2.3.RELEASE.jar:1.2.3.RELEASE]
    at org.springframework.boot.context.embedded.EmbeddedWebApplicationContext.selfInitialize(EmbeddedWebApplicationContext.java:221) [spring-boot-1.2.3.RELEASE.jar:1.2.3.RELEASE]
    at org.springframework.boot.context.embedded.EmbeddedWebApplicationContext.access$000(EmbeddedWebApplicationContext.java:84) [spring-boot-1.2.3.RELEASE.jar:1.2.3.RELEASE]
    at org.springframework.boot.context.embedded.EmbeddedWebApplicationContext$1.onStartup(EmbeddedWebApplicationContext.java:206) ~[spring-boot-1.2.3.RELEASE.jar:1.2.3.RELEASE]
    at org.springframework.boot.context.embedded.tomcat.TomcatStarter.onStartup(TomcatStarter.java:54) ~[spring-boot-1.2.3.RELEASE.jar:1.2.3.RELEASE]
    at org.apache.catalina.core.StandardContext.startInternal(StandardContext.java:5151) ~[tomcat-embed-core-8.0.20.jar:8.0.20]
    at org.apache.catalina.util.LifecycleBase.start(LifecycleBase.java:150) ~[tomcat-embed-core-8.0.20.jar:8.0.20]
    at org.apache.catalina.core.ContainerBase$StartChild.call(ContainerBase.java:1409) ~[tomcat-embed-core-8.0.20.jar:8.0.20]
    at org.apache.catalina.core.ContainerBase$StartChild.call(ContainerBase.java:1399) ~[tomcat-embed-core-8.0.20.jar:8.0.20]
    at java.util.concurrent.FutureTask.run(FutureTask.java:266) ~[na:1.8.0_45]
    at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1142) ~[na:1.8.0_45]
    at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:617) ~[na:1.8.0_45]
    at java.lang.Thread.run(Thread.java:745) ~[na:1.8.0_45]
Caused by: org.springframework.beans.factory.BeanCreationException: Could not autowire method: public void org.springframework.security.config.annotation.web.configuration.WebSecurityConfiguration.setFilterChainProxySecurityConfigurer(org.springframework.security.config.annotation.ObjectPostProcessor,java.util.List) throws java.lang.Exception; nested exception is org.springframework.beans.factory.BeanExpressionException: Expression parsing failed; nested exception is org.springframework.beans.factory.BeanCreationException: Error creating bean with name 'securityConfiguration': Injection of autowired dependencies failed; nested exception is org.springframework.beans.factory.BeanCreationException: Could not autowire field: private org.springframework.security.core.userdetails.UserDetailsService


a matter of law. Amgen, Inc. v. Chugai Pharmaceutical Co., 927 F.2d 1200, 1217 (Fed. Cir.), cert. denied, 502 U.S. 856, 112 S.Ct. 169, 116 L.Ed.2d 132 (1991).
The decisions of the Federal Circuit require the court to consider an assertion of indefiniteness, which would render the claim invalid under § 112 ¶ 2, from the point of view of those skilled in the art. Morton Int'l, Inc. v. Cardinal Chemical Co., 5 F.3d 1464, 1470 (Fed.Cir.1993). As stated in Orthokinetics, Inc. v. Safety Travel Chairs, Inc., 806 F.2d 1565, 1576 (Fed.Cir.1986):

*603 A decision on whether a claim is invalid under § 112, 2d ¶, requires a determination of whether those skilled in the art would understand what is claimed when the claim is read in light of theInc. Patent Litigation, 982 F.2d 1527, 1541 (Fed.Cir.1992). "Literal infringement requires that the accused device embody every element of the claims as properly interpreted." Texas Instruments, Inc. v. United States International Trade Com., 805 F.2d 1558, 1562 (Fed.Cir. 1986).

2. Infringement by equivalents
Even if the court were to conclude that the accused device does not literally infringe the patents-in-suit, the device may still infringe by operation of the doctrine of equivalents. The doctrine of equivalents is an equitable doctrine designed to prevent parties from realizing the benefits of another's patent by designing around the patent's literal language. Under the doctrine of equivalents, "infringement may be found if an accused device performs substantially the same function in substantially the same way to obtain substantially the same result." London v. Carson


wavelengths demonstrated unit-to-unit by light emitting diodes or "LEDs"). Based on their understanding that an oximeter monitor could be programmed with multiple sets of coefficients (each of which would provide sufficiently accurate calculations for particular ranges or groups of red and infrared LED wavelengths), Dr. New and Mr. Corenman determined to use an electrical component called a resistor[6] as the means for telling the oximeter monitor which set of coefficients to use with a particular probe. (D.I. 121 at 793-96; D.I. 122 at 952-55)
The construction and operation of a particular embodiment of a probe using the Rcal invention is described in the patent in the following manner:
LEDs 10, 20 are selected from batches of LEDs with generally known wavelength characteristics. The exact wavelength characteristics of the specific LEDslimitation of the asserted claims.

3. Doctrine of Equivalents
Even if BOC's OxyTip probe system does not literally infringe the asserted claims of the Rcal patents, the court concludes that said accused device infringes under the doctrine of equivalents. The BOC system performs: (1) substantially the same function (encoding and decoding to select calibration coefficients); (2) in substantially the same way (measuring the LEDs' wavelength values, assigning a resistor based on the known wavelength values, and identifying calibration coefficients based on information about the known wavelength values); (3) to achieve substantially the same result (selecting the appropriate available set of calibration coefficients and computing oxygen saturation with those coefficients). (D.I. 122 at 1041-45)

4. Reverse Doctrine of Equivalents  Section 112 Equivalence
BOC argues to the contrary, that "[e]ven if it can


"flexible, initially substantially planar, web-like support structure" capable of conforming to a patient's "skin without stressing either of said skin and the underlying tissue at any time during operation of said sensor probe...." The court concludes, therefore, that the adult OxyTip sensor infringes, literally and under the doctrine of equivalents, claim 1 of the '014 patent.[19] (D.I. 122 at 1063-69; DX 186A)
Nellcor also contends that BOC's Neonatal OxyTip infringes claim 1 of the '014 patent. As evidenced at trial, this accused product employs a "bag" construction whereby "a three-sided bag is initially formed, and thereafter, the optical components are inserted, but never secured to either the upper or lower surface defining that bag.... Finally, heat sealing is applied to close the open front, as well as the area118 at 125-27)
Claim 1 discloses "a flexible, initially substantially planar, web-like support structure" having "an adhesive layer on said lower surface for removably adhesively securing said lower surface to said convex portion of said skin...." Given the claim construction above, the court concludes that, while the BOC Neonatal OxyTip probe is comprised of a "web-like support structure," said support structure does not have "an adhesive layer on [the] lower surface" of the support structure. Therefore, the claim does not read on the accused device.
However, the court concludes that Nellcor has proven by a preponderance of the evidence that the Neonatal OxyTip infringes by virtue of the doctrine of equivalents. The accused device performs substantially the same function in substantially the same way to obtain the same result. Indeed,


local area and therefore, there wasn’t anybody willing to host tournaments. The second edition of ACE league was therefore carried out like that. I was finding a lot of companies to help sponsor/invest in the ACE league but due to uncertainty they all gave up.

Still many people do not understand why are the teams prohibited from attending smaller events.

Given that there will be big events all year round, we divided tournaments into different leagues. Already confirmed events are DSL (500,000RMB for champion), ACE (1.000,000RMB), TI3( 1,000,000USD). Due to scheduling conflict, there will be only one ACE tournament this year, while next year there will be two ACE events and two DSL events. This means there will be four events with considerable size of prize pool each year plusUniversity alumni
Category:Swedish geologists
Category:Quaternary geologists
Category:Swedish emigrants to the United States
Category:People from Västra Götaland County
Category:University of Arizona faculty
Category:Geoarchaeologists


La.Ann. 1247, 24 So. 240. In the course of time the definition of ex post facto was somewhat broadened in its effect and scope by the federal courts. Mr. Justice Breaux in State v. Baker, supra, reviewed the development in this way:
"They recognized as prohibited enactments when they attempted to make an act done before the passing of the law criminal which was not criminal when done, or when they sought to aggravate a crime or inflict a greater penalty, or to amend the rules of evidence, that would make worse and more difficult the defense of an act of prior date; (and, in addition to what had been previously held, when they affected any of the substantial rights of the accused)."[3] See also Thompson v. State ofproduction of the vehicle. Furthermore, the foam material rings are a weak element in relation to noise insulation behavior and water resistance. In vehicle bodywork and fuselages which in future will be made from fiber reinforced materials, for example CFRP, with novel geometric shapes of stiffening components such as stringers and frame elements the use of conventional elongated fastening pins will be hard to implement or will be impossible. It would, for example, be necessary, instead of a simple clamping connection or snap-on connection to implement an adhesive connection to arrange the fastening pins on the vehicle body or on the aircraft fuselage. This would also extend the time needed to fit out the vehicle.
In order to reduce the time required to fit out a vehicle cabin, it


the invention to do without excessive use of conventional fastening pins on the exterior skin of the vehicle. In addition, other objects, desirable features, and characteristics will become apparent from the subsequent summary and detailed description, and the appended claims, taken in conjunction with the accompanying drawings and this background.High-throughput two-hybrid analysis. The promise and the peril.
The two-hybrid method detects the interaction of two proteins by their ability to reconstitute the activity of a split transcription factor, thus allowing the use of a simple growth selection in yeast to identify new interactions. Since its introduction about 15 years ago, the assay largely has been applied to single proteins, successfully uncovering thousands of novel protein partners. In the last few years, however, two-hybrid experiments have been scaled up to focus on the entire complement of proteins found in an organism. Although a single such effort can itself result in thousands of interactions, the validity of these high-throughput approaches has been questioned as a result of the prevalence of numerous false positives in these large data sets. Such artifacts


Q:

Running MVC application under Cassini

I am trying to run Asp.Net MVC applications using Cassini but when i launch my application, all I get is directory listing and not the results of my default controller/action.
What I am I missing?
I need to mention that WebForms apps are running fine.

A:

Do you have any good reason for using standalone cassini ? I am not quite sure how "registration" of MVC stuff (route handlers, httphandler.. ) works with it - maybe it knows only about handlers for webforms. Do you know about the new IIS Express ? very lightweight and powerfull, full compatibility with IIS, maybe you could try it instead.

together and viewing it in a light most favorable to the verdict, we hold that it was legally sufficient to show a mutual mistake.
The Olsons further contend that the addendum is deficient regarding the description of deferred payments and interest terms, and thus, the statute of frauds bars its enforcement. We note that the jury was not asked whether there was a mutual mistake regarding these terms, and thus, reformation is not available as to those terms. The question is whether the option fails to satisfy the statute of frauds by not including these terms.
The statute of frauds does not require that a writing describe the consideration or terms of payment. Botello v. Misener-Collins Co., 469 S.W.2d 793, 794 (Tex.1971). Appellants' cases, except Wheeler v. White, 398 S.W.2d


Bayland delayed unreasonably in asserting its right to have the addendum reformed to reflect the true intent of the parties, and that this delay worked to the Olsons' disadvantage.
Bayland asserted its rights within the period of limitations. Absent estoppel or extraordinary circumstances, laches generally will not bar a suit brought within the limitations period. Barfield v. Howard M. Smith Co., 426 S.W.2d 834, 840 (Tex.1968). Bayland could not have sued for breach of contract before it exercised the option, and it sued within 50 days of the attempted closing. Moreover, there is no evidence whatsoever that appellants changed their position to their detriment because of the delay.
Point of error two is overruled.
In point of error three, appellants argue that the trial court erred in granting judgment for appelleenot in the record before us. Without it and without a record of the discussion with counsel, we must assume that the trial court properly admitted the exhibit.
The trial court sustained Bayland's objection to exhibit 11. The exhibit was a letter written from appellants' attorney to Harry Watters, attorney for Bayland. The grounds for the objection were that the letter contained a legal opinion about the validity of the option contract, that it was hearsay, and that it was immaterial. Even though appellants said they were offering the letter just to show notice, the primary focus of the letter was appellants' legal opinion, including a lengthy interpretation of cases, relating to reformation and the statute of frauds. The trial judge properly excluded the letter based on Tex.R.Civ. Evid.


the authority to classify loans and lenders, license and regulate lenders, define interest and fix maximum rates of interest; and providing for a maximum rate of interest of ten per centum (10%) per annum in the absense of legislation fixing maximum rates of interest. H.J.R. No. 6, 56th Legislature Regular Session, 1959 Tex.Gen.Laws, p. 1223.
Smith, at 21 n. 13.
We hold that Tex.Const. article XVI, section 11 limits Bayland's prejudgment interest to six percent, and we overrule the cross-point of error.
The judgment is affirmed.
NOTES
[1]  Appellants do not claim that the words "2472 Bolsover Bldg." were legally insufficient to describe the building they leased to appellee at that address. They claim only that it cannot support appellee's claim to the parking lots.
[2]  Smith, supra at 25 n. 23,1. Field of the Invention
The present invention relates to an anti-theft device, and more particularly to an anti-theft device for vehicles.
2. Description of the Prior Art
A typical anti-theft device for steering wheel of a vehicle is shown in FIG. 1 and comprises two hooks for engaging with the steering wheel and a shank for preventing the rotating of the steering wheel; however, the steering wheel is not suitably protected because the wheel is not enclosed, therefore the device can be disengaged from the steering wheel.
The present invention has arisen to mitigate and/or obviate the afore-described disadvantages of the conventional anti-theft devices for vehicles.


Karen Millen Jeans Patched Denim Collection

A denim closet refresh without breaking the bank? Yes, please! These patchwork Karen Millen jeans ($130) are giving me so much Lisa Turtle realness, I can hardly take it. Style them with a chambray shirt to up the true-blue ante.Schlagwort-Archive: SamLabs

After raising $4.5m, led by Imperial Innovations in May 2016, SAM Labs announces the release of a new kit, Curious: an immersive out-of-the-box inventing experience, allowing users to build and program their own cars and games.

Empowering youngsters worldwide to get hands on with smart tech, SAM Labs makes smart construction kits of clever little blocks and a fun app that gives everyone the power of technology to build awesome inventions. With the Curious building blocks and the SAM Space app, you’ll be stretching your imagination to create projects, games, inventions and hacks in no time.

Equipped with five paper-fold car bodies, a car base, and remote control, kids can build and program their own vehicles with SAM, whilst gaining 21st century skills. A step-by-step tutorial booklet, and the


= "<_builtin_>/sound/fantasy03.mid",
         integer_id = 60,
      },
      mcPuti = {
         file = "<_builtin_>/sound/dwarf.mid",
         integer_id = 61,
      },
      mcBoss = {
         file = "<_builtin_>/sound/battle1.mid",
         integer_id = 62,
      },
      mcBoss2 = {
         file = "<_builtin_>/sound/climax.mid",
         integer_id = 63,
      },
    file = "<_builtin_>/sound/morning_breeze.mid",
         integer_id = 85,
      },
      mcField1 = {
         file = "<_builtin_>/sound/orc04.mid",
         integer_id = 86,
      },
      mcField2 = {
         file = "<_builtin_>/sound/xp_field2.mid",
         integer_id = 87,
      },
      mcField3 = {
         file = "<_builtin_>/sound/xp_field4.mid",
         integer_id = 88,


Q:

Debian control file dependencies for a program which depends on libcurl.so, libsqlite3.so, libcrypto.so and libpthread.so

I am having a program which depends on libcurl.so, libsqlite3.so, libcrypto.so and libpthread.so
Package: myscript
Version: 0.1
Section: utils
Priority: optional
Architecture: all
Essential: no
Depends: curl | libcurl3, sqlite3 | libsqlite3-0, libcrypto++9 | libk5crypto3
Maintainer: Your Name
Description: Sample Program

My queries are,
1. I want to add libpthread dependency in the control file.My machine(linuxmint-17) is having a file named libthread.so.10. But while I am doing dpkg --get-selections , I am not getting any package containing pthread. It is a fresh installation of linuxmint(17) and I haven't manually installed any packages.
2.How will I ensure that this will work, let us say if libcurl4 or  libcrypto++99 comes in future.Am I following the correct method or am I missing something.

A:

At first, please read Debian documentationmay not be mixed in a single call to this function.

  @param  SupportedLanguages   A pointer to a Null-terminated ASCII string that
                               contains a set of language codes in the format
                               specified by Iso639Language.
  @param  Iso639Language       If TRUE, then all language codes are assumed to be


protocol.
  @retval Other                Some error occurs when locating Component Name (2) protocol instance or finding
                               the supported language.

**/
EFI_STATUS
DriverHealthManagerGetComponentNameWorker (
  IN  EFI_GUID                    *ProtocolGuid,
  IN  EFI_HANDLE                  DriverBindingHandle,
  OUT EFI_COMPONENT_NAME_PROTOCOL **ComponentName,
  OUT CHAR8          Component Name 2 protocol interface and try to get the controller name.
  If the attempt fails, it then gets the controller name from EFI 1.1 Component Name protocol for backward
  compatibility support.

  @param  ProtocolGuid         A pointer to an EFI_GUID. It points to Component Name (2) protocol GUID.
  @param  DriverBindingHandle  The handle on which the Component Name (2) protocol instance is retrieved.
  @param  ControllerHandle     The handle of a controller that the driver specified by This is managing.
                               This


   **ControllerName
  )
{
  EFI_STATUS                     Status;
  CHAR8                          *BestLanguage;
  EFI_COMPONENT_NAME_PROTOCOL    *ComponentName;

  //
  // Retrieve Component Name (2) protocol instance on the driver binding handle and
  // find the best language this instance supports.
  //
  Status = DriverHealthManagerGetComponentNameWorker (
             ProtocolGuid,
             DriverBindingHandle,
       it fails to get the controller name from Component Name protocol interface, we should fall back on
    // EFI 1.1 Component Name protocol interface.
    //
    Status = DriverHealthManagerGetControllerNameWorker (
               &gEfiComponentNameProtocolGuid,
               DriverBindingHandle,
               ControllerHandle,
               ChildHandle,
               &ControllerName
               );


      The handle of the child controller to retrieve the health
                            status on.  This is an optional parameter that may be NULL.
  @param HealthStatus       The health status of the controller.
  @param MessageList        An array of warning or error messages associated
                            with the controller specified by ControllerHandle and
                           ChildHandle.  This is an optional parameter that may be NULL.
  @param FormHiiHandle      The HII handle for an HII form associated with the
                            controller specified by ControllerHandle and ChildHandle.
**/
VOID
DriverHealthManagerProcessSingleControllerHealth (
  IN  EFI_DRIVER_HEALTH_PROTOCOL         *DriverHealth,
  IN  EFI_HANDLE                         ControllerHandle, OPTIONAL


 mDriverHealthManagerHealthInfo[Index].MessageList[MessageIndex].StringId,
                      NULL
                      );
        StringCount += UnicodeSPrint (String + StringCount, sizeof (String) - sizeof (String[0]) * StringCount, L"\n%s", TmpString);
        FreePool (TmpString);
      }
    }
    Help = HiiSetString (mDriverHealthManagerHiiHandle, 0, String, NULL);

    switch (mDriverHealthManagerHealthInfo[Index].HealthStatus) {
    case EfiDriverHealthStatusConfigurationRequired:
      Status = mDriverHealthManagerDatabase->GetPackageListHandle (
           interactions brought by the specific location of the different components in the final assembly (M...M interactions: DeltaE(M,M), and L...L interactions: DeltaE(L,L)), may additionally contribute to the total free energy change and affect f(inter). Beyond the determination of quantitative experimental values for these five parameters operating in various metal-containing assemblies, considerable efforts have been focused on their physico-chemical origins, with the ultimate goal of unravelling their chemical design. In this Feature Article, the bases are first considered leading to the emergence of the free additive thermodynamic model in metallo-supramolecular chemistry. A tutorial discussion of the current level of understanding of each microscopic thermodynamic describer follows, together with some selected practical applications in the field of polynuclear d-block and f-block complexes.


were imposing net costs on the tax system.

By MoH's last published note, they've retreated from their prior $1.9b estimate to $1-$1.6b: much lower than the Dom's cited number. I'd be curious whether MoH ever completed the work in progress and addressed the methodological issues.

That's an interesting one. The 2008 Collins & Lapsley report finds very high "social costs" of smoking, mostly consisting of things like smokers' expenditures on tobacco, the presumed valuation of reduced mortality, and deceased smokers' forgone household production. But actual medical costs aren't all that high.

Here's Table 42 of the Collins & Lapsley report.

Even if you include reduced taxes paid by smokers* due to excess mortality and morbidity, tobacco excise dwarfs everything else. Counting GST here is a bit tough; in the absence of smoking,and fees) on Orbitz with a stop in Boston. In real terms, the shorter US flight costs more and is less convenient. If I want a next-day flight, the NZ round trip is NZ$642 (US $514); Orbitz has the PIT-DCA route at US$635.

If you change things to American cities that are more comparable in size, like a routing from Toledo, Ohio to Erie PA, the New Zealand advantage gets a fair bit stronger: the next-day flight between those two is $1000 US and has two stops. Maybe there's just something weird about the airport combinations I've picked; they were random draws based on rough city size.

Point-to-point domestic travel within New Zealand has lots of small planes going between lots of small places, as well as a few higher


Gosset was a brewer and chemist working for Guinness who needed to know how many trials he needed to run to be confident in his results. And so we have the t-distribution.

I don't put huge confidence in each and every claim, and a lot of the innovations that were pushed by brewing likely would have come anyway for other reasons; it's implausible that somebody wouldn't have figured out refrigeration even if Pilsner had never existed. But would we be so wrong to claim that people who hate beer must also hate civilisation itself?

Wednesday, 25 April 2012

Salient, the student newspaper at the University of Victoria of Wellington,* tries to get to the bottom of popular complaints about the price of milk.** Skimming this late at night, I missed thegoal will have the government think again about the whole thing.

* I choose to avoid this risk, preferring the perilous whole milk and butter. I fear for Seamus though.

** I've read it twice, and I can't find a single reference to the "costs of smoking" number that MoH had been pushing a couple of years ago. Matthew Everett's the MoH contact person on the briefing document and is presumably the same Matthew Everett with whom I'd had fairly extensive discussion about the MoH's figure at the time. I'm glad to see that MoH doesn't seem to be pushing that figure any longer in its policy recommendations.

*** For both alcohol and tobacco, if anybody has ever seen estimates on the elasticity of informal supply through home production or smuggled


to people without tattoos.

The researchers suggest educators, parents and physicians consider tattoos and piercings as potential "markers" of drinking, using them to begin a conversation about alcohol consumption and other risky behaviors.

Again, nobody seems to be claiming that alcohol's a gateway drug to getting tattoos. Both of these point to underlying risk-preference as driving outcomes.

Finally, this one points to a more causal relationship. I'm not sure that causality is all that strongly established, but here's the abstract via Bakadesuyo:

A within-person multilevel approach was used to model the links between alcohol use and sexual behavior among first-year college students, using up to 14 days of data for each person with occasions (Level 1, N = 2879 days) nested within people (Level 2, N = 218 people; 51.4% male). Between-persons(Level 2) effects were gender, relationship status, person means of alcohol use, and alcohol-sex expectancies for sexual affect and sexual drive. Within-person (Level 1) effects were weekend days, number of drinks consumed, and the interaction between drinks consumed and alcohol-sex expectancies. Independent of average alcohol use, consuming more drinks on a given day was associated with a greater likelihood of oral sex and with experiencing more positive consequences of sex that day. Significant Alcohol Use × Alcohol-Sex Expectancies interactions were found for oral sex and total sex behaviors, indicating that individuals with more positive expectancies were more likely to have sex after drinking. The negative association between drinks and condom use was at a trend level of significance. Results support the potential for promoting sexual health by focusing


impact of internet fragmentation on economic growth and innovation, says Elder.

“We don't really understand how the openness of the internet creates economic value in and of itself,” he says.

Researching the kinds of global policies that will safeguard an open internet is a key need, agrees Ashnah Kalemera, programme officer at CIPESA (Collaboration on International ICT Policy for East and Southern Africa).

“Multi-stakeholder control of the internet is necessary given that the internet is a global resource,” she says. “The [GCIG] is very much needed to ensure equitable distribution [of control of the internet] and the sustained functioning of this model.”

Yet issues like internet access — still of primary concern in Africa, where only one fifth of the population has access to the internet — have been eclipsed by thelack of apps is a worry, but RIM has confirmed that it is solving this both by adding new apps, adding new features, and adding Android and BlackBerry 6 app support too. It has already proved that it plans to release updates that add rather than just bug fix, and you can expect that there are plenty more updates to due in the coming weeks. Thankfully it looks like the hardware will amply cope with the new features RIM and third party developers throw at it.

RIM’s UK MD put it nicely when we chatted with him recently: “It’s a marathon, not a sprint” and that seems to be the experience we’ve had as well while testing the PlayBook. Would we choose this over the iPad 2 or the


the naked eye, but because the DNA clumped in this activity you were able to see just how much of it three strawberries have when all of their octoploid cells are combined! (“Octoploid” means they have eight genomes.)

More to explore

Do-It-Yourself Strawberry DNA, from the Tech Museum of Innovation, Stanford School of Medicine

About Genetics, from the Tech Museum of Innovation, Stanford School of Medicine

DNA Extraction Virtual Lab, from Learn Genetics, the University of Utah

Do-It-Yourself DNA, from Science Buddies

This activity brought to you in partnership with Science Buddieskept up with the program since I used to go watch players like Avery Bradley, Tristan Thompson, Anthony Bennett and many others years ago.I know in those days the players had to keep their grades up.Now it sounds like the IMG football program.

You can play under CIF rules as long you do not have lower than a 2.0 two consecutive semesters. So if you had a 1.5 GPA semester one, then a 2.1 GPA semester two, you are playing regardless of the overall GPA. Not sure if Findlay prep plays by those same rules in Nevada. Either way there was more to Bol than just grades, his circle was bigger than the rose bowl and followed only his own rules. He is Findlay's headache now.


possible that the radiolucent process window is permeable to radiation that consists of particles, such as, e.g., alpha- and beta-radiation. This radiation can be then detected by the signal receiver. The explosion-proof device thus generally serves to detect radiation signals that are emitted by a process positioned on the side of the radiolucent process window not facing the electronic means. A radiation signal can merely consist of the radiation to be detected, being either present or not. A process can, for example, be a substance or mixture of substances in an aggregate state or multiple arbitrary aggregate states whose characteristics, presence or dynamics are to be monitored, determined or influenced.
Provisions for the construction and testing of intrinsically safe operating means that are determined for use in a fieldof electric energy within operating means and connecting pipes that are subject to an explosive atmosphere at a level below that at which ignition can occur due either to spark formation or heating.
A further possible type of protection is the pressure-proof encapsulation. In this type of protection, also called “ex-d”, the explosion protection is ensured by explosions possibly occurring within the capsule being shielded by the pressure-proof capsule in such a manner that a prevailing explosive atmosphere outside of the pressure-proof capsule is not ignited. Accesses in the wall of the capsule, thus, have to have an ignition spark resistant gap. The surface temperature of the capsule should not reach the ignition temperature of the surrounding explosive atmosphere in the case of an expected error. The standard EN


the show).

Following the series being cancelled in the UK in the mid-1970's (right as we were getting it ironically) three more Python films were released. They were "Monty Python and the Holy Grail," in 1975, "Life of Brian" in 1979 and "The Meaning of Life" in 1983.

The series and the movies have long been favorites on college campus's and with ... um .... stoners. I can't put that any other way: stoners love Python. With the admittedly insane style of humor employed by the show it sometimes greatly enhances the jokes if you are on another plane of reality at the time of viewing.

“Holy Grail" is by far their most popular film and the one that John Cleese himself was in Green Bay to bring us. An insanebut also of steadfast comedians such as Cleese. While the man has a career spanning nearly 50 years, hundreds of TV episodes, dozens upon dozens of films and yet it is his work with Python and Holy Grail specifically which will earn him longevity in America.

Cleese very much made Green Bay his own, entering the stage wearing a cheese hat and wasting no time in cracking jokes about "American Football" while also telling us the true story of how his family name was once Cheese but his father changed it to Cleese.

"Absurd and/or ridiculous questions only are requested, please." This was how the tickets were sold and indeed the audience lived up to this mantra.

Being a funny guy in real life as well as in the movies, Cleese


* @category Collection
 * @param {Array|Object|string} collection The collection to iterate over.
 * @param {Function} [iteratee=_.identity] The function invoked per iteration.
 * @param {*} [accumulator] The initial value.
 * @param {*} [thisArg] The `this` binding of `iteratee`.
 * @returns {*} Returns the accumulated value.
 * @example
 *
 * _.reduce([1, 2], function(total, n) {
 *   return total + n;
 * });
 * // => 3
 *
 * _.reduce({ 'a': 1, 'b': 2 }, function(result, n, key) {
 *   result[key] = n * 3;
 *   return result;
 * }, {});
 * // => { 'a': 3, 'b': 6 } (iteration order is not guaranteed)
 */
var reduce = createReduce(arrayReduce, baseEach);

module.exports = reduce;
someone peeled a layer of gauze off my brain. I’m having fun with different recipes and enjoying researching all the hows and whys of this way of living. I’ll try to make an effort to update as I progress through this but in the meantime here are a few of my favorite Paleo blogs:

What Runs Lori <– Not sure if she is full Paleo but she has a lot of Paleo recipes.

Second, Mike and I have made some upgrades to my tri bike. We re-wrapped the bars with matching blue wrap (after youtubing a how-to), added my beloved Speed Play pedals in blue and ordered new arm pads for the aero bars. Right now it’s sitting at our LBS getting a little tune-up to make sure everything is


wonderful husband:

The Orbea Ordu, full carbon frame and Shimano Ultegra components. The story of this bike is too amazing not to share. The original owner (aka the guy we bought it from) had herniated 3 disks in his back and was paralyzed from the waist down. The doctors predicted he would never walk without a cane again. After intense physical therapy he not only walked unassisted, he trained for and completed a full Ironman! This is the very bike he rode those 112 miles on! I feel so inspired by the history of this bike and honored to be the next one to ride it. Who knows, maybe it has two Ironmans (Ironmen?) in it! 😉

Moving right along to the running addiction from the cycling addiction. Week twocontribution to good causes. The plan now is to recover a bit. Through early June the training I have planned will be a bit more relaxed, more of an emphasis on CrossFit. With the incredibly successful completion of this season I have set some pretty big goals for myself for the next one.

Share this:

Like this:

Another year, another Gasparilla Distance Classic. This was my third year participating and my second year running the 15K (ran the 5K my first year). I had the lofty goal of pacing 8 minute miles, which given my recent 5K and 10K performances wasn’t too much of a stretch. Unfortunately, like last year it was insanely hot and that really affected both my enjoyment level and performance. My horrible pre-race nutrition might have also


Tropicana Field, through downtown, around the Dali and then the Pier, up to Snell Isle and finally finishing in front of Vinoy Park. Sherry ran so strong and crushed her goal! Being there with her as she crossed the finish line, meeting her goal of a sub 2-hour half marathon, was very motivating!

We collected our medals and then headed off to find Jena and Glenna in the family meet-up spot. Prior to the race we had agreed to meet at the letter S but it was the only letter missing! Eventually we all found each other and headed back to the car to put on some more clothes. Jena said what we were all thinking, that it wouldn’t break her heart if we headed to brunch without returninginvalid  tag which has no src attribute ... -->

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the report shows that these two metrics are often closely linked. He explained that the “change of who is in the White House has had a big impact on how the world sees the United States.” Global confidence in the U.S. president to “do the right thing in world affairs” has declined from 64 percent to 22 percent with the advent of the new administration. Concurrently, favorable views of the United States have dropped from 64 percent to 49 percent. Russia, as Wike noted, is the significant outlier with a net increase in both of these metrics.

Wike reported a “steep slope downward” in favorability among Europeans between Presidents Obama and Trump, with European views of the current president roughly on par with those for President George W. Bushexpress EPO and a suicide gene and we will infuse them into wild type and CKD mice to measure their effectiveness in regulating hematocrit levels in vivo. Specific aim 2 focuses on extending these genetic modifications to human T cells and testing them in vitro for their ability to be propagated long-term via chronic viral antigen stimulation, as well as inducibly express EPO and undergo selectively induced cell ablation if needed. In specific aim 3, we will evaluate the functionality of genetically modified human T cells from patients with CKD and determine the frequency of EBV-specific T cells and their response to EBV antigen in the presence and absence of transgenically expressed EPO ex vivo. PUBLIC HEALTH RELEVANCE: This project is focused on developing an efficient, safe, and


while Aruna had claimed bronze at 2018 Gymnastics World Cup.

But World Championships are a different ball game where even reaching the finals has proved to be a difficult task for Indian gymnasts in the past.

In the men’s section, the focus will be on 2010 Asian Games bronze medallist Ashish Kumar, while the team will also have Yogeshwar Singh and Aditya Singh Rana.

Olympic quotas will also be up for grabs with the top nine teams in each discipline (excluding the three already qualified from 2018) set to qualify for the Tokyo Games.

Individual Olympic berths will also be at stake as the top 12 male and top 20 female gymnasts, which will be decided by rankings in the all-around competitions, will qualify for Tokyo Games.

Additionally, the three top gymnasts inTyrone and in Derry, areas that bordered his constituency in West Ulster. From around late 1968 onwards, Blaney formed and presided over an unofficial Nationalist group in Leinster House popularly known as 'the Letterkenny Table', so named because this group of politicians used to meet at a certain table in either the Dáil bar or the Dáil restaurant. The group was dominated by Blaney up until his death. He had also been one of a four-member Cabinet sub-committee set up to decide on government policy to Northern Ireland together with Haughey, Pádraig Faulkner and Joseph Brennan. A fund of £100,000 was set up to give to the nationalist people in the form of aid. However, those involved have denied that the government supported the importation of arms.

There was


Palmitoylation of tubulin.
Tubulin is a very water soluble protein, yet a significant portion is firmly associated with cell membranes. Because recent work has shown that palmitoylation is a dynamic process that can alter the targeting of proteins to membranes, we tested whether or not tubulin could be palmitoylated to account for its membrane location. Tubulin acylation was measured by incorporation of [3H]palmitate into PC12 cells in culture. We found palmitoylated tubulin in both cell pellet and cytosol with a higher concentration in the former. EGF-stimulated PC12 cells incorporated the same amount of palmitate per unit protein but the proportion in the membrane fraction was enhanced. More palmitate of the pellet was found in alpha than beta tubulin; EGF stimulation primarily increased palmitate in beta tubulin. In addition weRoss gives a detailed and honest account of how Etsy went from a raw startup in 2005, to a startup struggling with their success in 2007, to the mean, handmade, super scaling, ops driven machine they’ve become in 2011.

There’s lots to learn from this illuminating story of transformation:

Origin Story

Etsyis a market for handmade goods. They connect buyers and sellers, similar to eBay, they don’t handle goods.

To fix their scalability problems they created middleware layer called Sprouter - Stored procedure router.

Sprouter was a Python daemon sitting between the webservers and the database. You give it some arguments, it calls the stored procedure, and returned the results. In theory it could some caching and sharding, but these features weren't implemented.

The hope was the Sprouter would be easier to scale than


failure.

2008 - The Great Etsy Culture Shift

Chad Dickerson was hired as the CTO and later became the CEO. He brought in a new culture and the previous culture was no longer at Etsy.

Removing the old culture also removed:

Devotion to PostgreSQL and stored procedures.

Fear of developers coding in SQL.

Fear of developers touching the product in general.

The idea that of infrequent and large deployments are the way to move code into production.

A general NIH attitude.

Spring 2009 - The Way Forward: Part 1

DevOps to the Rescue

DevOps are Ops people who are also engineers and engineers who are also Ops.

Upgrade database vertically as far as possible. Still not enough, but bought some breathing room.

Give developers production access to running code so they can help fix problems. Developed a tool called StatsD. ThoughQ:

Splitting a string into a two separate lists of numbers and letters -python

The title sort of says it all.  For example:
I want to split
stringtosplit = 'hello57world'

into
letters = ['h','e','l','l','o','w','o','r','l','d']
numbers = ['5', '7']

then make both of them back into strings,
letters = 'helloworld'
numbers = '57'

is there any neat way to do this?  I want to keep my code as concise as possible.  Numbers and letters can occur anywhere in the string and whitespace and special characters are already filtered out.

A:

>>> stringtosplit = 'hello57world'
>>> letters = []
>>> numbers = []
>>> for k in stringtosplit:
...     if k.isalpha() == True:
...         letters.append(k)
...     elif k.isdigit() == True:
...


055 A1 in the form of a housing to receive one reversible small electric motor each for the coordinated drive of each of two tappet-like linear actuators, which may be extended out of the housing and/or withdrawn therein opposite to one another. In this way, they tilt a support plate around an axis centrally transverse to the connection line between the two linear actuators. The requirement of having to simultaneously use two motorized drives acting oppositely coordinated for this simple pivot movement of a mirror support plate around a pivot axis is, however, very costly. In addition, the operational reliability is impaired due to the danger of not exactly synchronized operation; if the two linear actuators are not moved exactly opposite by their motors, then a reproducible tiltingregion, which may have tension or pressure loads applied to it like the central region due to its material selection or its constructive guide. These adjustment rods, which comprise different regions and are only necessarily toothed in their central region, are therefore not necessarily toothed rods which are constructively costly since they are continuously flexible per se.
The support plate is preferably centrally, e.g., spherically, mounted on its back side, opposite its mirror surface, on the housing. The flexible regions of the adjustment rods on both sides of the linear toothed rod regionxe2x80x94mounted in the housing so it is longitudinally displaceable approximately parallel to the support plate by the adjustment motor via a reduction drivexe2x80x94each first run into the housing through a curved guide and then out of the


this linkage, the technology of snap connections having spherical overlap surfaces as joints for movement transmission may be used, as may be produced without problems and with functional reliability in plastic injection molding.
A similar adjustment rod, which is driven by a motor in its toothed central region, may be aligned transverse to the first mentioned, in order to be able to carry out the pivot movement of the spherically mounted plate around two axesxe2x80x94and also with simultaneous superposition in any arbitrary spatial direction.
In any case, as the plate is tilted around an axis, one half of the adjustment rod, which is curved, is subjected to a compressive load and its opposing half is subjected to a tensile load, which ensures a pivot drive able to be subjected tohigh mechanical stress and operating without vibration or pinching, at least if the plate is tiltable around a constructively defined point of rotationxe2x80x94due to its spherical linkage mounting on the housingxe2x80x94and is broadly supported on two further points at a distance to one another via the end pieces of the respective rods. Therefore, according to the present invention, in a stably operating tilting device, particularly for the support plate of a motor vehicle outside mirror adjustable by a motor, the plate is mounted using an articulated joint on a housing which is to be mounted in a fixed location, in which a drive motor is positioned, for each of the two orthogonal pivot directions (which may also be superimposed into any desired spatial direction), which engages with a


sincere and speaks for itself. The phrases “This must be a great loss for you and your family” or “It’s obvious how much CoCo was loved” acknowledge that you recognize the loss as significant and can invite the owners to share their feelings. Sometimes they will tell stories of the dog as a puppy or how the cat helped them through a stressful time. These are the beginning moments to this person dealing with her loss.

ØListen, wait, listen

Active listening extends beyond the borders of passive silence. It requires skill, understanding and patience. It requires you to hear the client’s words and ascertain the feelings behind the words without argument, judgment or interruption. Remember that they will experience this particular loss only once.

ØRead body language

This art at the timeMusician Gets Help From Delta And Gibson After Baggage Handlers Wrecked Guitar

It was a terrible day for rock music in Detroit, Hanukkah-themed and otherwise, when Delta staff forced musician Dave Schneider to check his vintage Gibson guitar as luggage and it got caught in a service elevator. The instrument wasn’t destroyed beyond repair, but the repairs were going to cost an estimated $2,000. Then there was a rock miracle. Gibson, the iconic company that made his guitar half a century ago, offered an amazing opportunity: they could offer him not just a factory tour and a 50th anniversary replica of a similar model, but also repair his damaged guitar for free.

Delta, for their part, doesn’t have a guitar factory, but they did offer to pay for the instrument


measures of physical activity and nutrition related to knowledge, attitudes, and behaviors 1 week before (time 1) and 1 week after (time 2) the intervention. The intervention group was more efficacious at time 2 on measures of self-efficacy, pros, cons, intentions, and behavior related to physical activity. This group also reported more favorable changes in practicing healthy eating, balancing food intake with activity level, cooking meals with techniques to reduce fat, and avoiding eating high-fat foods. Effect sizes for all significant differences were small. E-mail is a promising mode of delivery for promoting physical activity and nutrition in the workplace. Further theoretically driven studies are needed.For a fair portion of my business life, I have been connected with Silicon Valley as a major think-tank of tech and business minds. I also founded a company there in 2016 — ABC Silicon Valley, dedicated to advanced start-ups from all over the world that would like to expand their operations to that area. 2018, however, marked my exit from ABC Accelerator to focus on Eligma − the biggest start-up story I have ever been part of. This story could never succeed without standing on the shoulders of entrepreneurial giants worldwide. Consequently, my ties to the US and especially Silicon Valley became even stronger as major input providers come from that area. My tour last week was dedicated to visiting at least some of them as well


and Herman Gyr

Richard and Barbara Pivnicka, and the Band of Angels

As Honorary Consuls of the Czech Republic and the Slovak Republic respectively, Richard and Barbara Pivnicka are amongst those who have made trade and commerce between the US and European continents their life’s mission. Richard Pivnicka is a patent inventor and highly active in the start-up and VC domains; he founded CzechTech, an organization connecting Czech and Silicon Valley businesses. Barbara Pivnicka is a renowned business executive and a global thought leader. She is President and CEO of the San Francisco Global Trade Council. The meeting with Richard and Barbara was dedicated to the prospects of Eligma venturing beyond the national and continental borders.

Meeting with Richard and Barbara Pivnicka

The Pivnickas are both members of the Band of Angelswic services, a nutrition program for women, infants and children, improves the health of pregnant women and their children. Chat online in musselshell, united states with over 330m members on badoo, you will find someone in musselshell make new friends in musselshell at badoo today. Musselshell county, montana's gender ratio is equal to the montana state average of 101 men to 100 women (101:100) or 101 the gender ratio is also higher than the national average of 97 men to 100 women (97:100) or 097.


IEEE 802.3 Ethernet.
Accordingly, there exists a need for an improved multi-port card that obviates or reduces some of these drawbacks. It is important to note that the present disclosure is not intended to be limited to a system or method which must satisfy one or more of any stated objects or features of the invention. It is also important to note that the present disclosure is not limited to the preferred, exemplary, or primary embodiment(s) described herein. Modifications and substitutions by one of ordinary skill in the art are considered to be within the scope of the present disclosure, which is not to be limited except by the following claims.and management off of you and onto Microsoft's operations - it lets you and your team focus on what you want to do - write code and create product.
You asked about it being on a windows azure subscription.  To be clear, you're not deploying TFS on your azure subscription - tfs.visualstudio.com is a multi-tenant instance of TFS that you can sign-up for that's deployed on Microsoft's azure subscription.  The invitation codes have also recently been lifted so go ahead, sign up and try it out.
You could however get your own azure subscription and deploy TFS (basics or express) on VM in your own azure subscription.
The pros and cons are:

tfs.visualstudio.com is currently free and gives you core TFS with little friction.
having your own instance in your own