mounting evidence that male obesity may be equally implicated in reducing fertility and embryo health. Couples with an overweight or obese male partner, with a female of normal body mass index (BMI), have increased odds ratio for increased time to conceive compared with couples with normal weight male partners.” – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521747/

“Fertility doctors yesterday advised obese men to lose weight if they want to start a family, after research linked a dramatic fall in sperm quality to rising body weight.

Being overweight can definitely be a factor. Fats release estrogens into the body which cause serious hormonal imbalances in men & women.

You might want to consider that nutrition is critical in male fertility. If a man is not getting enough of certain vitamins & minerals (zinc, selenium, etc), sperm qualityof pure rFGF-1, pure rFGF-1 encapsulated in liposomes and lipid spheres \[[@CIT0008]\], pure rFGF-1 added to standard o/w and w/o emulsions, and finally the composition of rFGF-1 and lipid spheres from o/w and w/o emulsions was carried out. Fingerprints of pure substances were generated at a depth of 15--25 µm. All samples were applied on skin explants (10 µl each) from female donors (23--26 years of age) and incubated for 72 h on metal strainers. Those skin explants were used only to investigate the skin system penetration.

*In vivo* study {#S20006}
---------------

The study sample comprised 25 women in the age range between 51 and 59 with visible signs of aging. All the volunteers signed the consent to participating in the test. The enrolled women applied the anti-wrinkle creams day and


even to allow the migration of both lipophilic and hydrophilic active substances into the skin \[[@CIT0015]\]. For that reason, nowadays the use of nano- and micro-lipid spheres in cosmetology is growing. The lipid-based formulations seem to be the most appropriate ones for the topical application of active substances because they contain physiological and biodegradable lipids which have affinity with the stratum corneum. When applied externally they do not affect its function \[[@CIT0016]\].

The rFGF-1 is a large protein of 15.196 kDa. Its isoelectric point is 8.12, and it has a positively charged patch on the surface \[[@CIT0017]\]. Due to the large size of this protein there was a necessity to check its penetration abilities through the stratum corneum. To assess the depth of Q40P/S47I/H93G rFGF-1 penetration, the Raman Spectroscopyingredients of o/w formulation could act as enhancers and caused rFGF-1 to penetrate deeper (to a depth of 90 µm into the skin) than the composition of rFGF-1 and lipid spheres, which migrated to a depth of 60 µm ([Figure 7](#F0007){ref-type="fig"}), what definitely needs further investigation. A feature of lipid particles (lipid spheres) particularly important from a cosmetology point of view is the creation of a discontinuous occlusive layer on the skin\'s surface. If the particle size is smaller, their adhesion to the skin is stronger and the occlusion is more effective. This reduces transepidermal water loss, thereby increasing the hydration and elasticity of the skin. Occlusion also has a positive impact on the penetration of active substances into the skin. This has been proven for the Coenzyme


even though the populate match filters based on the author's name, Mongoose still returns all the books, including those whose author.name doesn't match. If author.name isn't 'Ian Fleming' , the book's author property will be null .

That's because, under the hood, Mongoose translates Book.find().populate('author') into 2 queries:

const books = await Book.find({}) Author.find({ _id: { $in: books.map(b => b.author) }, name: 'Ian Fleming' })

So populate() finds all books first, and then finds the corresponding authors.

Store What You Query For

If you need to filter books by the author's name in a performant way, the right way is to store the author's name in the book document:

const Book = mongoose.model( 'Book' , Schema({ title: String , author: { type: mongoose.ObjectId, ref: 'Author' }, authorName: String })); const authorSchema = Schema({ name:Laser Marking of Metal

Marking metal for traceability, quality control, and personalization with permanent, durable, and legible marks is a growing need in manufacturing. Laser metal marking is the most recent solution to this challenge that offers many advantages over traditional marking techniques. Using a variety of laser wavelengths, permanent marks can be made on almost any type of metal including but not limited to: Aluminum, Brass, Carbide, Chrome, Cobalt, Copper, Gold, Nickel, Platinum, Silver, Stainless Steel, Steel, Tin, Titanium, Zinc, etc.

Methods of Laser Marking of Metal:

There are four main methods used when marking metal using lasers. Each method provides its own unique type of mark. The engineers at Control Micro Systems, Inc. will develop an application around your requirements using the method that fits your needs.

Ablation – The


layer such as paint or anodization from a metal surface. In many cases, the precise control of the laser energy can remove the extra layer to reveal the unaffected metal below.

Control Micro Systems, Inc’s custom laser metal marking machines are used all over the world in a variety of industries. Let us help you with your metal marking challenge today! Please contact us with your laser metal marking requirements for free sample processing on your parts by filling out the sidebar contact form.Q:

Don't understand the answer to a uniform distribution question with conditional probability for probability and statistics.

The question is this:
You arrive at a bus stop at 10 A.M., knowing that the bus will arrive at some time uniformly distributed between 10 and 10:30.
(a) What is the probability that you will have to wait longer than 10 minutes
The answer is the integral from 10 to 30 of 1/30dx. I don't understand why it is the integral of 1/30.
(b) If, at 10:15, the bus has not yet arrived, what is the probability that you will have to wait at least an additional 10 minutes?
The answer is p(X>25|X>15) which I understand however I don't understand why the answer is then p(X>25)/p(x>15).

A:

As you mentioned in the setup of


+ name + "=" + val;
  }

string r_layer (string name, int lay)
  {
    return "|" + name + "=" + layer [lay];
  }

string ra_net (int n)
  {
    if (n == -1) return "";
    return r_i ("NET", n);
  }

string ra_comp (int c)
  {
    if (c == -1) return "";
    return r_i ("COMPONENT", c);
  }

int fixwidth (int w)
  {
    return ((w == 0) ? 2540 : w);
  }

// PCB data storage

string arcs = "";
string comps = "";
string fills = "";
string header = "";
string nets = "";
string pads = "";
string texts = "";
string tracks = "";
string vias = "";

int arcs_c = 0;
int comps_c =}

void out_track (UL_WIRE w, int n, int c)
  {
    if (w.arc)
      {
        out_arc (w.arc, n, c);
        return;
      }
    tracks += record ("Track") + ra_net (n) + ra_comp (c)
             + r_i ("INDEXFORSAVE", tracks_c) + r_b ("SELECTION", 0) + r_layer ("LAYER", w.layer)
             + r_b ("LOCKED", 0) + r_b ("POLYGONOUTLINE", 0) + r_b ("USERROUTED", 1)
             + r_l ("X1", w.x1, x0) + r_l ("Y1", w.y1,


     psh [PAD_SHAPE_THERMAL] = "bug"; //!
    pads += record ("Pad") + ra_net (n) + ra_comp (c)
           + r_i ("INDEXFORSAVE", pads_c)
           + r_s ("LAYER", "MULTILAYER") + r_b ("LOCKED", 0) + r_b ("USERROUTED", 1) + r_s ("NAME", p.name)
           + r_l ("X", p.x, x0) + r_l ("Y", p.y, y0)
           + r_l ("XSIZE", p.diameter [LAYER_BOTTOM] * (1 + p.elongation / 100), 0) + r_l ("YSIZE", p.diameter [LAYER_BOTTOM], 0)
           + r_s ("SHAPE", psh [p.shape [LAYER_BOTTOM]]) +r_l ("HOLESIZE", p.drill, 0) + r_f ("ROTATION", p.angle)
           + r_b ("PLATED", 1)
        // + r_s ("DAISYCHAIN", "Load")
        // + ... ... ...
         + endr ();
    pads_c ++;
  }

void out_smd (UL_SMD s, int n, int c)
  {
    pads += record ("Pad") + ra_net (n) + ra_comp (c)
           + r_i ("INDEXFORSAVE", pads_c)
           + r_layer ("LAYER", s.layer) + r_b ("LOCKED", 0) + r_b ("USERROUTED", 1) + r_s ("NAME", s.name)


    + r_l ("X1", r.x1, x0) + r_l ("Y1", r.y1, y0) + r_l ("X2", r.x2, x0) + r_l ("Y2", r.y2, y0)
             + r_f ("ROTATION", r.angle)
          + endr ();
    fills_c ++;
  }

void out_hole (UL_HOLE h, int c)
  {
    pads += record ("Pad") + ra_comp (c)
           + r_i ("INDEXFORSAVE", pads_c)
           + r_layer ("LAYER", LAYER_TOP /*incorrect*/) + r_b ("LOCKED", 0) + r_b ("USERROUTED", 0)
           + r_s ("NAME", "")+ r_l ("X", h.x, x0) + r_l ("Y", h.y, y0)
           + r_l ("XSIZE", h.drill, 0) + r_l ("YSIZE", h.drill, 0)
           + r_s ("SHAPE", "ROUND") + r_l ("HOLESIZE", h.drill, 0) + r_f ("ROTATION", 0)
           + r_b ("PLATED", 0)
        // + r_s ("DAISYCHAIN", "Load")
        // + ... ... ...
         + endr ();
    pads_c ++;
  }

void out_net (UL_SIGNAL s)
  {
    netn [nets_c] = s.name;
    nets += record ("Net")


("INDEXFORSAVE", comps_c) + r_b ("SELECTION", 0)
            + r_layer ("LAYER", (e.mirror ? LAYER_BOTTOM : LAYER_TOP))
            + r_b ("LOCKED", 0) + r_b ("POLYGONOUTLINE", 0) + r_b ("USERROUTED", 1) + r_b ("PRIMITIVELOCK", 1)
            + r_l ("X", e.x, x0) + r_l ("Y", e.y, y0) + r_s ("PATTERN", e.package.name) + r_b ("NAMEON", hasDes)
            + r_b ("COMMENTON", hasComm) + r_i ("GROUPNUM", 0) + r_i ("COUNT", 0) + r_f ("ROTATION", e.angle)
            + r_i ("COMMENTAUTOPOSITION", 0) + r_i ("CHANNELOFFSET",indicates a match or mismatch result of the comparison between the stored data word and the search word. All match lines indicating a match condition are typically processed by a priority encoder to determine a highest priority match address which is provided as an output of the CAM.
Each data word and match line combination has a unique N-bit address within the CAM. Accordingly, for any search cycle there may be up to 2N match lines activated. As mentioned, the CAM typically includes a priority encoder for generating the N-bit address corresponding to the highest priority active match line. This N-bit address may be used for network applications such as Internet Protocol (IP) routing table lookup, compression and decompression as well as fully associative cache memory implementations in microprocessor


Introduction {#Sec1}
============

Previous studies have shown that the 1-month survival rate among children who experienced out-of-hospital cardiac arrest (OHCA) remains very low (5.2--12.8%). The quality of cardiopulmonary resuscitation (CPR) performance may be the key factor affecting survival in patients who had OHCA^[@CR1]^. According to the 2015 American Heart Association (AHA) Guidelines Update for CPR and Emergency Cardiovascular Care, a high-quality CPR involves appropriate chest compression rate, proper chest compression depth, complete chest recoil, minimisation of compression interruptions, and avoidance of excessive ventilation. Appropriate chest compression creates blood flow primarily by increasing intrathoracic pressure and directly compressing the heart, which results in blood flow and oxygen delivery to the heart, brain, and other vital organs. Complete chest recoil ensures adequate coronary perfusion pressure and myocardial blood flow^[@CR2]^. Poor-quality CPR performancethe Pearson chi-square test for discrete variables such as CCRV. Statistical significance was set at *P* \< 0.05. All statistical analyses were performed using the SPSS software (version 22.0; SPSS Inc., Chicago, IL, USA).

Consent for publication {#Sec7}
-----------------------

All authors have reviewed and approved the manuscript for publication.

Ethics approval and consent to participate {#Sec8}
------------------------------------------

The study protocol was approved by the Institution Review Board and ethics committee of Chang-Gung Memorial hospital.

Results {#Sec9}
=======

A total of 75 personnel participated in the study including 19 paediatric fellows, 27 paediatric residents, 14 clerks, and 15 paediatric critical care nurses. The age of the participants was between 20 and 39 years. The number of male and female participants was 24 (32%) and 51 (68%), respectively. Of them, 14 participants (18.7%) were trained in only BLS and 61 participants


EXCEPTION_CONVERT(env);
	return 0;
}

/*
 * java.lang.String getText()
 */
JNIEXPORT jstring JNICALL Java_com_scriptographer_ui_MenuItem_getText(JNIEnv *env, jobject obj) {
	try {
		AIMenuItemHandle item = gEngine->getMenuItemHandle(env, obj);

#if kPluginInterfaceVersion < kAI12
		char text[256];
#else
		ai::UnicodeString text;
#endif
		if (!sAIMenu->GetItemText(item, text))
			return gEngine->convertString(env, text);
	} EXCEPTION_CONVERT(env);
	return NULL;
}

/*
 * void setText(java.lang.String text)
 */
JNIEXPORT void JNICALL Java_com_scriptographer_ui_MenuItem_setText(JNIEnv *env, jobject obj, jstring text) {
	try {
		AIMenuItemHandle item = gEngine->getMenuItemHandle(env, obj);
#if kPluginInterfaceVersion < kAI12
		char *textStr = gEngine->convertString(env, text);
		sAIMenu->SetItemText(item, textStr);
		delete textStr;
#else
		ai::UnicodeString textStr = gEngine->convertString_UnicodeString(env, text);
		sAIMenu->SetItemText(item, textStr);
#endif
	} EXCEPTION_CONVERT(env);
}

/*
 * void setOptions(int options)
 */
JNIEXPORT void JNICALL Java_com_scriptographer_ui_MenuItem_setOptions(JNIEnv *env, jobject obj, jint options) {
	try {
		AIMenuItemHandle item = gEngine->getMenuItemHandle(env, obj);
		sAIMenu->SetMenuItemOptions(item, options);
	} EXCEPTION_CONVERT(env);
}

/*
 * int getOptions()
 */
JNIEXPORT jint JNICALL Java_com_scriptographer_ui_MenuItem_getOptions(JNIEnv *env, jobject obj) {
	try {
		AIMenuItemHandle item = gEngine->getMenuItemHandle(env, obj);
		long options = 0;
		sAIMenu->GetMenuItemOptions(item, &options);
		return options;
	} EXCEPTION_CONVERT(env);
	return 0;
}

/*
 * void setEnabled(boolean enabled)
 */
JNIEXPORT void JNICALL Java_com_scriptographer_ui_MenuItem_setEnabled(JNIEnv *env, jobject obj, jboolean enabled) {
	try {
		AIMenuItemHandle item = gEngine->getMenuItemHandle(env, obj);
		if (enabled) {
			sAIMenu->EnableItem(item);
		}The Self-Defeating Flirtation

Start here

My friends and I discovered a paradox of dating/picking up long ago, which I have discussed before slightly differently: essentially, humans have an ironic and disastrous habit of assuming the people they’re more attracted to aren’t attracted to them.

Let’s take a moment and dissect that. The people you think are hottest, the people that you reeeeally think you might click with, the people that you really fucking want are the ones who you’re most likely to think, “Aw, s/he’s just not that into me.” I’ve had many conversations with people where they readily admitted that they couldn’t tell someone was interested in them because of their own interest; behaviors that appeared flirtatious from someone they were not interested in immediately became ambiguous or neutral because


Ontogeny of Ha-ras and c-myc mRNA levels in rabbit embryo and extraembryonic tissues by quantitative in situ hybridization.
A large variety of proto-oncogenes are known to be of key importance in cellular growth and differentiation during embryonic development. Using quantitative in situ hybridization, we studied in detail the levels of the proto-oncogenes Ha-ras and c-myc mRNA in embryos and extraembryonic tissues (maternal and embryonic placentas, trophoblast, and endometrial epithelium) during prenatal life of rabbit. cDNA probes encoding for Ha-ras (fragment Kpn 1-BstE II of 883 bp) and c-myc (fragment Pst 1-Pst 1 of 490 bp) were used to detect specific transcripts in fixed cryostat sections. High levels of Ha-ras and c-myc mRNA were detected in the rabbit embryo as well as in the decidua and in the trophoblast asthe vehicle and responded by calling police and securing the building, the chief said.

It also elicited a speedy police response.

Three minutes after the school called police at 11:48 a.m., Sherwin said he was the first officer to arrive at the scene. He was followed soon after by multiple officers and troopers from the Castleton and Fair Haven police departments, Vermont State Police and the Vermont Department of Motor Vehicles Enforcement Division.

“This was an appropriate response for the type of call this was,” Sherwin said. “Everyone acted according to pre-planned directives. Fortunately, it turned out to be a larceny rather than an actual threatening situation.”

School officials declined to answer questions about the incident, but the Addison-Rutland Supervisory Union issued a statement later in the day:

“There was a disturbance that


err
	}
	return dAtA[:n], nil
}

func (m *PluginPrivilege) MarshalTo(dAtA []byte) (int, error) {
	var i int
	_ = i
	var l int
	_ = l
	if len(m.Name) > 0 {
		dAtA[i] = 0xa
		i++
		i = encodeVarintPlugin(dAtA, i, uint64(len(m.Name)))
		i += copy(dAtA[i:], m.Name)
	}
	if len(m.Description) > 0 {
		dAtA[i] = 0x12
		i++
		i = encodeVarintPlugin(dAtA, i, uint64(len(m.Description)))
		i += copy(dAtA[i:], m.Description)
	}
	if len(m.Value) > 0 {
		for _, s := range m.Value {
			dAtA[i] = 0x1a
			i++
			l = len(s)
			for l >= 1<<7 {
				dAtA[i] = uint8(uint64(l)&0x7f | 0x80)
				l >>= 7
				i++
			}
			dAtA[i] = uint8(l)
			i++
			i += copy(dAtA[i:], s)
		}
	}
	return i, nil
}

func encodeVarintPlugin(dAtA []byte, offset int, v uint64) int {
	for v >= 1<<7 {
		dAtA[offset] = uint8(v&0x7f | 0x80)
		v >>= 7
		offset++
	}
	dAtA[offset] = uint8(v)
	return offset + 1
}
func (m *PluginSpec) Size() (n int) {
	var l int
	_ = l
	l = len(m.Name)
	if l > 0 {
		n += 1 + l + sovPlugin(uint64(l))
	}
	l = len(m.Remote)
	if l > 0 {
		n += 1+ l + sovPlugin(uint64(l))
	}
	if len(m.Privileges) > 0 {
		for _, e := range m.Privileges {
			l = e.Size()
			n += 1 + l + sovPlugin(uint64(l))
		}
	}
	if m.Disabled {
		n += 2
	}
	if len(m.Env) > 0 {
		for _, s := range m.Env {
			l = len(s)
			n += 1 + l + sovPlugin(uint64(l))
		}
	}
	return n
}

func (m *PluginPrivilege) Size() (n int) {
	var l int
	_ = l
	l = len(m.Name)
	if l > 0 {
		n += 1 + l + sovPlugin(uint64(l))
	}
	l = len(m.Description)
	if l > 0 {
		n += 1 + l + sovPlugin(uint64(l))
	}
	if len(m.Value) > 0 {
		for _, s := range m.Value {
			l = len(s)
			n += 1 + l + sovPlugin(uint64(l))
		}
	}
	return n
}

func sovPlugin(x uint64) (n int) {
	for {
		n++
		x >>= 7
		if x == 0 {
			break
		}
	}
	return n
}
func sozPlugin(x uint64) (n int) {
	return sovPlugin(uint64((x << 1) ^ uint64((int64(x) >> 63))))
}
func (m *PluginSpec) Unmarshal(dAtA []byte) error


{
				return ErrInvalidLengthPlugin
			}
			postIndex := iNdEx + intStringLen
			if postIndex > l {
				return io.ErrUnexpectedEOF
			}
			m.Env = append(m.Env, string(dAtA[iNdEx:postIndex]))
			iNdEx = postIndex
		default:
			iNdEx = preIndex
			skippy, err := skipPlugin(dAtA[iNdEx:])
			if err != nil {
				return err
			}
			if skippy < 0 {
				return ErrInvalidLengthPlugin
			}
			if (iNdEx + skippy) > l {
				return io.ErrUnexpectedEOF
			}
			iNdEx += skippy
		}
	}

	if iNdEx > l {
		return io.ErrUnexpectedEOF
	}
	return nil
}
func (m *PluginPrivilege) Unmarshal(dAtA []byte) error {
	l := len(dAtA)
	iNdEx := 0
	for iNdEx < l {
		preIndex := iNdEx
		var wire uint64
		for shift := uint(0); ; shift += 7 {
			if shift >= 64 {
				return ErrIntOverflowPlugin
			}
			if iNdEx >= l {
				return io.ErrUnexpectedEOF
			}
			b := dAtA[iNdEx]
			iNdEx++
			wire |= (uint64(b) & 0x7F) << shift
			if b < 0x80 {
				break
			}
		}
		fieldNum := int32(wire >> 3)
		wireType := int(wire & 0x7)
		if wireType == 4 {
			return fmt.Errorf("proto: PluginPrivilege: wiretype end group for non-group")
		}
		if fieldNum <= 0 {
			return fmt.Errorf("proto: PluginPrivilege: illegal tag %d (wire type %d)", fieldNum, wire)
		}
		switch fieldNumIntroduction
============

Alzheimer's disease (AD) is the most common cause of senile dementia.[@b1-dddt-9-1419] It was first described by Alois Alzheimer in 1906.[@b2-dddt-9-1419] In 2012, there were 36 million people worldwide with AD. It is predicted to affect more than 115 million people globally by 2050.[@b3-dddt-9-1419] It is a progressive, neurodegenerative disorder that is usually diagnosed in people over 65 years of age.[@b4-dddt-9-1419]

Donepezil is a reversible acetylcholinesterase inhibitor that has been approved for use for AD. It is believed to inhibit the breakdown of the neurotransmitter acetylcholine and compensate for the deficiency of acetylcholine in brain.[@b5-dddt-9-1419],[@b6-dddt-9-1419] In previous clinical trials, it has been shown to improve cognitive function in patients for a wide range of AD severity, from very mild to moderate-to-severe.[@b7-dddt-9-1419]--[@b11-dddt-9-1419]

The most common adverse events (AEs) with donepezil, as well


the first published study to investigate the tolerability and pharmacokinetics of the donepezil patch in healthy subjects. After application, the donepezil patch provided a smooth and sustained plasma concentration--time profile over the entire patch-on period of 72 hours. For the highest dose of donepezil (175 mg/50 cm^2^) administered in this study, about 20% of the dose (approximately 35 mg) was released from the patch over the 72-hour application. As per the clinical pharmacology and biopharmaceutics review, the pharmacokinetic profile of 10 mg single-dose oral donepezil was reported to produce an AUC~inf~ of 885.30±249.10 ng/mL and a C~max~ of 20.90±5.00 ng/mL.[@b25-dddt-9-1419] Systemic exposure (AUC~inf~) after a 72-hour application of 175 mg/50 cm^2^ was about three times higher than after the single dose of a 10 mg oral tablet, whileThe present disclosure relates generally to integrated circuit devices, and more specifically, to a device to monitor electrical activity in a through-silicon-via (TSV).
An integrated circuit (IC) is a semiconductor device containing many small, interconnected components such as diodes, transistors, resistors, and capacitors. These components function together to enable the IC to perform a task, such as control an electronic device, or perform logic operations. ICs are found in computers, calculators, cellular telephones, and many other electronic devices.
ICs and other semiconductor devices are fabricated on small rectangles, known as “dies,” which are filled with multiple layers of the components, such as transistors, resistors, and capacitors, during the fabrication process. The connections between the layers are known as through-silicon-vias (TSVs), or vias, for short. In integrated circuit design, a via


As a company or an enterprise grows in size, the management of access to enterprise resources becomes increasing difficult. As one example, employees of an enterprise may wish to utilize their own personal devices to access such enterprise resources. In an enterprise with only a few employees, registration of such personal devices to access enterprise resources is readily handled. For example, an IT administer or even the personal device user can manually register such personal devices to access the enterprise resources.
However, when an enterprise includes thousands of employees, such manual registration is no longer a feasible solution. Moreover, management of the enterprise resources often requires registered devices to be located within the corporate firewall. As a result, employees of the enterprise are unable to access enterprise resources fromBICYCLE FINANCE
We have developed a finance product specifically for the enthusiastic cyclist to stay relevant and on top of the rapidly advancing sport of cycling. An added benefit is that an upgrade at any time is possible. We will show you how cost of ownership can beat the purchase price.

WHAT CAN I FINANCE?
New bicycle frame from manufactured approved dealer (indicating serial number)
Wheels
Attachments
All accessories (e.g. GPS and navigation)


OS. When you think about it, this idea is not that far-fetched. Now, on the same operating system developers are writing applications for that already stream TV (think Slingbox or Netflix), surf the web, pull up your favorite magazine publications, and more, developers just need to change the screen size to adapt the experience for that specific screen size and experience.

So, what if Steve Jobs is not trying to dominate the world directly? What if he is build a family of devices that all use the same operating system, the iPhone OS? This would give Apple an ecosystem that allows software developers to create applications that will work on multiple devices. The software developer would really just need to change the presentation for each display, and developers are 35 (31, 38)        0.08 (0.06, 0.09)       70 (63, 78)

  1993       54 (28, 90)        5.50 (3.90, 7.20)   0.01 (0.00, 0.01)       35 (32, 39)        0.09 (0.07, 0.10)       99 (90, 110)

  1994       55 (28, 90)        5.50 (4.00, 7.30)   0.01 (0.01, 0.01)       35 (32, 39)        0.10 (0.08, 0.13)


incidence rates have increasing trend in Iran

-   incidence, prevalence, and death rates of TB have decreasing trend in Iran

-   The average annual of HIV/TB mortality and incidence have increased more than 10%

-   Approximately after 2010, decreasing trend of incidence, prevalence, and death rates of TB has stopped and its direction has changed.

-   The time pattern of TB incidence and prevalence were relatively unsteady in Iran from 1990 to 2014
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interact directly and co-operate to facilitate transport of cargo from microtubules to actin tracks. Processive motion will be followed at the single molecule level using TIRF-microscopy. Structural approaches (collaboration with K. Taylor) will be used to gain insight into how the motors interact in the absence or presence of their tracks. Mutations in myosin V lead to Griscelli syndrome (hypopigmentation and neurological impairment). Myosin IX plays a role in cell-signaling, because the GAP domain in its tail (its "cargo") is believed to regulate Rho-dependent remodeling of the cytoskeleton in motile cells and in the dynamic arrays of actin in synapses. A number of human diseases result from disruption of cargo transport along actin or microtubules, or from disease proteins acting as cargo for these transport proteins. A betterevery single system. So
even within ONE agency, every system's implementation is done from scratch.

It's the perfect kind of thing that could've been an open source library
(still in a classified network though), but still extremely valuable. It's
something I built and recommended to my superiors ten years ago when I worked
for a government contractor, but we didn't get much traction for various
reasons. (Cynically, most contractors want the free money to reimplement it,
so they aren't going to stop that gravy train.)

So there is a LOT of room even within each single agency, to share code that
is common to their business practices.

You'll be hard pressed to find an area in any large organization (public or
private) that couldn't benefit from the efficiencies of reuse.

------
moon_of_moon
Why is this limited to software?

Why not also publish publicly


be everything.

~~~
batbomb
GPL is discouraged in government software (speaking from DOE/NSF experience)
but BSD or similar is encouraged. The path of least resistance is
private/closed source, followed by open source BSD/MIT/Apache, followed by
GPL/LGPL, followed by commercialization.

The reason why there is a bit of resistance with open source as a default is
because funding has to be traced.

------
bpchaps
Heh. I submitted a FOIA request two weeks ago for code for a $100M system used
for storing parking ticket data. They have 5 days to ask for an extension, but
they haven't even responded with that.

Guess I'm going to lawyer up again..

~~~
MichaelApproved
What is the penalty for not responding in time?

~~~
bpchaps
For Illinois, two big things - 1\. They can't reject the FOIA with "unduly
burdensome" anymore, which is an incredibly common and frustrating response.
2\. They can be sued fornot complying, which then becomes a slow drawn out
process. The upside is that it's something like 8k if the judge thinks the
request was rejected/ignored intentionally or without proper followup.

Example - I did a FOIA that was rejected absurdly unfairly. Going through the
attorney general took about 6 months to hear a response back, which Chicago's
lawyer then used essentially a mistype to throw that request out. 8 months in
total there. Fast forward 6 months later and we have a court date with a lot
of small things in between then and now.

~~~
ChrisDutrow
Why do these get rejected? Is it just people being lazy? Or people not
understanding how to handle the request? Seems like a lot of work for them to
go to court?

~~~
bpchaps
A few things -

1\. Definitely a lot of laziness from the


--TEST--
Dynamic hover selector
--CSS--
a:hover {display: inherit;}
--EXPECT--
array (
  'a:hover' =>
  array (
    'display' => 'inherit',
  ),
)
                                  (          2          )
Here, dv and dc shown in Equations (1) and (2) are parameters that indicate the number of “1” along the vertical direction (columns) and the horizontal direction (rows) of the check matrix H and that can be arbitrarily selected, respectively. For example, in the case of a code (3, 6), equations dv=3 and dc=6


the roof could be estimated from the size of the foundations, but the roof structure remains guesswork - different techniques of thatch have been used on each house.'

As an exercise in experimental archaeology, it has revealed many unknown facts about building materials and techniques. Because of deadlines for the Stonehenge Visitor Center, however, not all techniques employed were Neolithic! But inside, the walls are daubed, furnished with timber and wicker beds and shelves, clay pots and jars, and a central hearth, the houses reflect a genuine Neolithic dwelling.Conventional photoconductive detectors comprise one or more square elements of photosensitive material, each element having a pair of spaced bias contacts. For imaging applications, such a detector is placed in the image plane of an optical assembly and is usually shielded to reduce the incidence of background illumination upon the detector. The detector is usually mounted on a cold stage and is cooled to enhance signal-over-noise discrimination. In one form of conventional detector apparatus using intrinsic photoconductive elements responsive to the middle and far infra-red region of the spectrum, a steady direct current (DC) bias, from a constant current source, is applied to each element. There is thus developed across each detector element a bias pedestal voltage, a voltage dependent on bias current magnitude and element resistance. When


now. They have Vulcans, Brookville & Plymouths & several pieces of rolling stock at that location. Ray & I were debating that they decided to match the Vulcan since it was 24 in ga originally & they did not have to push it in.

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You cannot post new topics in this forumYou cannot reply to topics in this forumYou cannot edit your posts in this forumYou cannot delete your posts in this forumYou cannot post attachments in this forumimproved in its oxygen sensing performance while it is held at a predetermined temperature, there has been proposed an oxygen sensor incorporating a heater for heating the oxygen sensing element. In this case, however, it is necessary to dispose such heater in the interior of the oxygen sensing element, that is, inside the inner electrode layer, so particularly in the case of using a rod-like ceramic heater as such heater, a problem is encountered in the fixing method for the heater body. And in the case of using a coil-like terminal, there will not occur breakage of the oxygen sensing element because a clamping stress is not applied thereto, but it is not easy and is troublesome to fit such terminal threadedly in the internal thread portion.
Moreover, the


heater is fixed using an adhesive or the like to heat the oxygen sensing element. But, in this case, the heater cannot be fixed firmly due to a change of the adhesive or the like with the lapse of time caused by heating or vibration, thus resulting in damage of the inner electrode layer or the heater itself.   }
}

function setCookie(c_name, value, exdays) {
    var exdate=new Date();
    exdate.setDate(exdate.getDate() + exdays);
    var c_value=escape(value) + ((exdays==null) ? "" : "; expires="+exdate.toUTCString());
    document.cookie=c_name + "=" + c_value;
}

function getCookie(c_name) {
    var i,x,y,ARRcookies=document.cookie.split(";");

    for (i=0;i<ARRcookies.length;i++) {

        x=ARRcookies[i].substr(0,ARRcookies[i].indexOf("="));
        y=ARRcookies[i].substr(ARRcookies[i].indexOf("=")+1);
        x=x.replace(/^\s+|\s+$/g,"");

        if (x==c_name) {
            return unescape(y);
        }
    }

    return null;
}

function finalResults() {
    var dc, current, loss, noise, pi,


products were electrophoresed on 1.5% agarose gels, visualized using ethidium bromide staining and quantified using Quantity One software (Bio-Rad). β-actin served as the internal positive control and as the reference gene for PCR cycle number normalization. This ensured linear amplification of the templates in each experiment. The primers used in PCR were as follows: Forward, 5′-AGGGTAAATGGTAGTTGAAAGGA-3′ and reverse, 5′-ACGCTGGGAAATGAAGAAGA-3′ for ER-1 (product, 280 bp); forward, 5′-TTTAGTGGTCCATCGCCAGTTA-3′ and reverse, 5′-CAGCTCTTGCGCCGGTTT-3′ for ER-2 (product, 339 bp); and forward, 5′-TCATGAAGTGTGACGTGGACAT-3′ and reverse, 5′-CTCAGGAGGAGCAATGATCTTG-3′ for β-actin (product, 158 bp).

Western blot analysis
---------------------

Monoclonal mouse anti-PKCα and mouse anti-human β-actin antibodies were purchased from Santa Cruz Biotechnologies (Santa Cruz, CA, USA), and polyclonal rabbit anti-human phospho-PKCα (Thr638) antibodies were purchased from Cell Signaling Technology, Inc. (Beverly, MA, USA). Total protein was extracted using a lysispathway by these herbs may be involved in the synergistic mechanism of these formulae. However, Ginsenosides and Astragaloside are also able to repress the JNK signaling pathway ([@b35-ol-09-02-0837],[@b36-ol-09-02-0837]), the activation of which is the main mechanism of cantharidin cytotoxicity ([@b6-ol-09-02-0837],[@b8-ol-09-02-0837]). Repression of JNK by Ginsenosides and Astragaloside may impair the anticancer effect of cantharidin, which suggests that a relatively specific PKC inhibitor may be a more effective choice in a multi-component therapy.

In our previous study, the addition of a PKC inhibitor, GF109203X, to treatment regimes was found to increase the cytotoxicity of cantharidin ([@b8-ol-09-02-0837]). However, GF109203X has not been applied in clinical trials. Furthermore, cantharidin cytotoxicity to the normal hepatic and urinary system tissues restricts the clinical application of this drug ([@b9-ol-09-02-0837]). Thus combination treatment with PKC inhibitors


media has been a game-changer when it comes to the conversation around fertility issues, Syrtash says, adding that “More and more communities are speaking up and speaking out about pregnancy loss and struggles to conceive. Celebrities and public figures are also sharing their experiences. Women are more empowered than ever to share their stories, take control of their bodies and be proactive about their health.”

Infertility takes its toll on the body and mind

Fertility issues affect both men and woman and have a range of health impacts. Emotional stress can result in anxiety and depression. Massive hormone doses take a toll on the body as do the treatments themselves, which are invasive and often painful, and have low success rates. For example, the success rate for IVF in womenVitro Fertilization) and IUI (Intrauterine Insemination), and the drugs that go with them varies dramatically around the world. Prices range from as low as $2,250 for IVF in China to, as Syrtash said, $15,000 in some US states.

Success rates and treatment quality also vary by location. Because of these disparities, as well as legal prohibitions in certain countries, fertility tourism, or reproductive tourism is on the rise. People often travel from countries like Germany, for examples, which places restrictions on the number of embryos that can be created per cycle, to get IVF elsewhere. Popular destinations for fertility treatments include Spain, the Czech Republic, and Mexico.

Opportunities for the wellness industry

Brands should want to reach these people, says Syrtash. In fact, she and pregnantish are forming partnerships to address


Wesleyan University Philippines

Wesleyan University-Philippines (WU-P) is a private, non-stock, non-profit and non-sectarian university located in Cabanatuan City, Nueva Ecija, Philippines and run by the United Methodist Church (UMC). Founded in 1946 as the Philippine Wesleyan College, it is named after John Wesley, the founder of Methodism. The university offers pre-elementary, grade school, high school, undergraduate, and graduate programs. It also initiated the SHARE (Studentship Assistance for the Handicapped and their Rehabilitation through Education) program, the first school in Central Luzon to integrate hearing-impaired students into mainstream classes.

The University was granted a five-year autonomy by the Commission on Higher Education effective March 11, 2009.

Its acronym may be written as WUP or WU-P. It is one of the four 'Knowledge Eagle Universities of Nueva Ecija.'

History

Wesleyan University - Philippines was openedshirt.

Date published: 2016-02-22

Rated 5 out of
5 by
Nicolelee from
So pretty!!I just love this tee it's super stylish perfect for us girls with extra weight runs a tad small I bought a 1 fits looks great but if you like a baggy tee go up a size !! Still love mine lots of people saying love that shirt!!

Date published: 2016-02-21

Rated 5 out of
5 by
Krisha from
Great shirtShirt fits perfectly and goes well with the gray rebel jeans I got.

Date published: 2016-02-20

Rated 5 out of
5 by
fragglerocker99 from
Fell in loveSaw this while browsing the store and tried it on . . . I fell in love with it. So soft; loose, but falls in a very flattering, drapey way on my body; and comfortable. Can be dressed up with a blazer or down


Q:

Why does the mutable StringBuilder behave like the immutable string when a reference is changed?

The "C# 4.0 IN A NUTSHELL" 4th edition book by the Albaharis states on page 249:
". . . calling object.ReferenceEquals guarantees normal referential equality."
So, I decided to test this out.
First I tried value types like this.
 int aa1 = 5;
 int aa2 = aa1;
MessageBox.Show("object.ReferenceEquals(aa1,aa2) is: " + object.ReferenceEquals(aa1, aa2));

And just as I expected, the result was false:
object.ReferenceEquals(aa1, aa2) is: False
Life was good.
Then I tried a mutable reference type like this.
System.Text.StringBuilder sblr1 = new System.Text.StringBuilder();
sblr1.Append("aaa");
System.Text.StringBuilder sblr2 = sblr1;
MessageBox.Show("object.ReferenceEquals(sblr1,sblr2) is: " + object.ReferenceEquals(sblr1, sblr2));

And just as I expected, the result was true
object.ReferenceEquals(sblr1, sblr2) is: True
Life was still good.
Then I figured that since itactually is not true.  The fact that you're setting one string variable to null doesn't really have anything to do with the string being immutable.  That's a separate concern.

Why then is the mutable reference type behaving just the same as the immutable reference type?

The behavior you're seeing has nothing to do with mutability.  It is the standard behavior for all reference types (whether immutable or mutable).  Mutability is a different issue.
The main issue with mutability is this:
Suppose you have a class, like so:
class Foo
{
    public int Bar { get; set; }
}

If you write this:
Foo a = new Foo();
a.Bar = 42;
Foo b = a;
b.Bar = 54;
Console.WriteLine(a.Bar); // Will print 54, since you've changed the same mutable object

With immutable types, this


Compressive sensing (CS) is a recently developed technique. Considering the fact that a large part of natural and artificial signals have the sparse or near sparse property, the compressive sensing technique can find applications in many different areas like compressive imaging, compressive sampling, signal processing, data stream computing, and combinatorial group testing, etc. The basic idea of compressive sensing is that a sparse signal x (a signal is referred to as sparse if it contains much more zero elements than non-zero elements) with length-N can be accurately recovered from a linear measurement y=Ax of length-M, wherein A is the M×N measurement matrix, M<<N.
The reconstruction can be performed through minimizing ∥x∥0 that explains the measurement vector. As this minimization problem is NP hard, sub-optimal algorithms have been investigated. Majorout to dryprovided proof that, indeed, chemicals such as nonylphenol ethoxylates (NPE) are being used in the manufacture of these famous brands.

Nonylphenol ethoxylates break down to form nonylphenols which is extremely toxic and has endocrine disrupting properties.

Sports apparel brands are heavy in the promotion of physical fitness, healthy lifestyles and general well-being. Go to any big sports event in any part of the world; most likely, it is sponsored by one of the above brands. Because their products are endorsed by particular athletes, those of us who tend to look up to them, also emulate the way they act and look, even copy their manner of dressing. It all looks great on the surface.

However, behind these wonderful-looking sports apparel and the healthy lifestyle brands promote, is a dirty


time in our life. God bless you.

Thank you so much for going out of your way to help me with my ticket. I really appreciate it. Thanks again.

Jon’s a good friend of mine. I hired him to handle my personal injury case. When I told him the insurance company hadn’t offered anything (including to pay my hospital bills), he was taken aback. He handled the case from beginning to end and we settled with the insurance company for $50,000.

I appreciate your help to finish a fight that I certainly didn’t ask for. Your kindness and professional help got me through it all. Thanks Again.

We just wanted to thank you and your office for everything you have done for our family! You really helped save our year! Thanks atumor necrosis factor-alpha and interferon-gamma production in polyclonally activated T-cell cultures from G1 patients, when compared with G2. Furthermore, high levels of interleukin-10 were produced both systemically and by activated T-cell cultures from G1 patients. Interestingly, the neutralization of endogenous interleukin-10 by anti-interleukin-10 monoclonal antibody elevated both the inflammatory cytokines' release and the HIV-1 replication in the polyclonally activated T-cell cultures from G1 patients. Additionally, the maternal antiretroviral treatment significantly enhanced the systemic interleukin-10 production. Finally, the higher systemic interleukin-10 levels were inversely correlated with vertical virus transmission risk. These results indicate that a high tendency of pregnant women to produce interleukin-10 can help them control the HIV-1 replication, and this can reduce the risk of vertical transmission. Furthermore, our data suggest a role for maternal antiretroviral treatment


One: The early adventures of Dick Grayson as Robin. Not essential for Batman, but recommended considering Grayson's enduring impact on Bruce over the years.

Batgirl: Year One: The story of how Barbara Gordon took up the cowl as Batman's newest sidekick, Batgirl. As with Robin: Year One, this is not essential for Batman, but recommended nonetheless since it provides a context for several future stories.

Interlude

This section is a break in the chronology. Along with the Joker and Bane, Ra's al Ghul and his daughter Talia are the villains with the most lasting impact on Batman's stories. Recommending introductory reading for Ra's and Talia includes:

Birth of The Demon: The origin of Ra's al Ghul and his enmity with Batman.

Son of The Demon: The evolution of Bruce and Talia's relationship. Taliawith Gotham as the prize. The Knightfall Saga begins here, and as such this is recommended reading for a full appreciation of the story about to unfold.

Knightfall Saga

This one's going to take some explaining. Bear with me.

Prelude to Knightfall: In Batman #484-489, Bruce starts to fear he's lost his edge after failing to apprehend Black Mask. He finds it hard to maintain his focus and resolve, and contacts a therapist named Shondra Kinsolving for help. At the same time, he directs Tim Drake to train Jean-Paul Valley in detective work, hoping to make Valley a reliable ally in the war against crime. Against Dr. Kinsolving's advice, Bruce pushes himself further and further, causing his health to deteriorate.

Simultaneously, in Detective Comics #654-656, Bruce's fatigue is underlined more and more


will get help from Catwoman with whom he will have a love affaire. He will finaly reveal his identity to her.

Under the Hood: This story brings back the long-dead Jason Todd. He returns with rage against Batman and becomes the antihero Red Hood.

Batman & Son: Batman discovers he has a 9 year old son (Damian) with Talia Al Ghul when she decides to drop him on him while fighting the Joker who poisonned his friend Jim Gordon.

Batman against much greater forces

With Batman & Son, Grant Morrison starts a 7 years collaboration with Batman that can be considered as a super-arc.

R.I.P.: The black glove organisation leaded by Dr. Hurt try to distroy everything Batman stands for.

Final Crisis: Dr. Hurt's doing is part of a much larger plan lead bythe city.

Robin War: In the abscence of Robin (Damian Wayne), a mouvement "We Are Robin" formed. With Damian back, he will try to put an end to all this "Robin" mess.

Rebirth

After Flashpoint, Wally West, the current Flash at that time got trap in the speed force, and everyone forgot about him and how it was before. In this Rebirth event, Wally tries to escape his trap by reaching on his former friends (the different Justice League members). Bary Allen the current Flash will remember him, enabling Wally to have enaught energy to free himself. Having broken the barrier, every heroes will start to remember the past.

Batman Epilogue: Batman is taken to the future as well as his past, questioning who he is, how he came to be and


conveniently-timed tweets distract the public and dominate the headlines, his attorney general continues to bulldoze over the Constitution, knocking down what scant protections remain between the citizenry and the hydra-headed police state.

Within his first year as attorney general, Jeff Sessions has made a concerted effort to expand the police state’s power to search, strip, seize, raid, steal from, arrest and jail Americans for any infraction, no matter how insignificant.

What this means is more militarized police, more asset forfeiture, more private prisons, more SWAT team raids, more police shootings of unarmed citizens, and more wars waged by the government against the American people.

And while the crime rate may be falling, the death toll—casualties of the government’s war on the American people—is growing.

The body count will continue to mount aslong as the courts continue to march in lockstep with the police state, as long as police unions continue to strong-arm politicians into letting police agencies get away with murder, as long as legislators continue to care more about getting re-elected than about protecting the rights of the citizenry, as long as police continue to treat their fellow citizens as enemy combatants on a battlefield, as long as the media continues to focus the spotlight on circus politics, and as long as the citizenry fail to be alarmed and outraged every time the police state shoots another hole in the Constitution.

Even so, it’s not just the police shootings that are cause for concern.

We are inching ever closer to a constitutional crisis the likes of which we have never


Franklin Street, Fifth Floor, Boston, MA
**  02110-1301, USA.
*/
#include "mu-parser.hh"
#include "mu-tokenizer.hh"
#include "utils/mu-utils.hh"
#include "utils/mu-error.hh"

using namespace Mu;

// 3 precedence levels: units (NOT,()) > factors (OR) > terms (AND)

// query	->      <term-1> | ε
// <term-1>	->	<factor-1> <term-2> | ε
// <term-2>	->	OR|XOR <term-1> | ε
// <factor-1>	->	<unit> <factor-2> | ε
// <factor-2>	->	[AND]|AND NOT <factor-1> | ε
// <unit>	->	[NOT] <term-1> | ( <term-1> ) | <data>
// <data>       ->      <value> | <range> | <regex>
// <value>      ->      [field:]value
// <range>      ->      [field:][lower]..[upper]
// <regex>      ->      [field:]/regex/

#define BUG(...) Mu::Error (Error::Code::Internal, format("%u: BUG: ",__LINE__)	\
				     +format(__VA_ARGS__))

static Token
look_ahead (const Mu::Tokens& tokens)
{
	return tokens.front();
}

static Mu::Tree
empty()
{
	return {{Node::Type::Empty}};
}

static Mu::Tree term_1 (Mu::Tokens& tokens, ProcPtr proc, WarningVec& warnings);

static Mu::Tree
value (const ProcIface::FieldInfoVec& fields, const std::string& v,
       size_t pos, ProcPtr proc, WarningVec& warnings)
{
	auto val = utf8_flatten(v);

	if (fields.empty())
		throw BUG("expected one or more fields");

	if (fields.size() == 1) {
		const auto item = fields.front();
		return Tree({Node::Type::Value,
			     std::make_unique<Value>(
				     item.field, item.prefix, item.id,
				     proc->process_value(item.field, val),
				     item.supports_phrase)});
	}

	// a 'multi-field' such as "recip:"
	Tree tree(Node{Node::Type::OpOr});
	for (const auto& item: fields)
		tree.add_child (Tree({Node::Type::Value,
				      std::make_unique<Value>(
					      item.field, item.prefix, item.id,
					      proc->process_value(item.field, val),
					      item.supports_phrase)}));
	return tree;
}

static Mu::Tree
regex (const ProcIface::FieldInfoVec& fields, const std::string& v,


size_t pos, ProcPtr proc, WarningVec& warnings)
{
	if (v.length() < 2)
		throw BUG("expected regexp, got '%s'", v.c_str());

	const auto rxstr = utf8_flatten(v.substr(1, v.length()-2));

 	try {
		Tree tree(Node{Node::Type::OpOr});
		const auto rx = std::regex (rxstr);
		for (const auto& field: fields) {
			const auto terms = proc->process_regex (field.field, rx);
			for (const auto& term: terms) {
				tree.add_child (Tree(
					{Node::Type::Value,
					 std::make_unique<Value>(field.field, "",
								 field.id, term)}));
			}
		}

		if (tree.children.empty())
			return empty();
		else
			return tree;

	} catch (...) {
		// fallback
		warnings.push_back ({pos, "invalid regexp"});
		return value (fields, v, pos, proc, warnings);
	}
}

static Mu::Tree
range (const ProcIface::FieldInfoVec& fields, const std::string& lower,
       const std::string& upper, size_t pos, ProcPtr proc,
       WarningVec& warnings)
{
	if (fields.empty())
		throw BUG("expected field");

	const auto& field = fields.front();
	if (!proc->is_range_field(field.field))
		return value (fields, lower + ".." + upper, pos, proc, warnings);

	auto prange = proc->process_range (field.field, lower, upper);
	if (prange.lower > prange.upper)
		prange = proc->process_range (field.field, upper, lower);

	return Tree({Node::Type::Range,
			   * Test that When the request addresses a detached (and thus, focused-upon) portlet, returns
     * true.
     */
    @Test
    public void trueWhenAddressesSpecificPortletDetached() {

        when(this.syntaxProvider.getPortalRequestInfo(mockRequest))
                .thenReturn(this.portalRequestInfo);
        when(this.portalRequestInfo.getUrlState()).thenReturn(UrlState.DETACHED);

        assertTrue(predicate.test(this.mockRequest));
    }

    /**
     * If for whatever reason the portal request info returned form the syntax provider is null,
     * return false, since null does not represent a request focused on a single portlet.
     */


Company (China). The HepG2 cells were inoculated into the 60mm cell culture dish (5 ml/well) by density of 1 × 10^5^cells/ml. When the cells reached 80% confluence, Lipofectamin2000 (Invitrogen) was used to transfect miR-101 mimics, miR-101 inhibitor and miRNA NC mimics into HepG2 cells according to the instructions, respectively. According to the method reported by literatures, plasmids were transfected into HepG2 cells in order to perform the knockout of the Girdin gene ([@b2-molce-39-2-96]). 48h after transfection, the fluorescence microscopy and the qRT-PCR were used to detect whether the cell cloning process was successful.

CCK-8 test
----------

48 h after transfection, the cells were inoculated to a 96-well plate by 5 × 10^3^ cells for each well. Five repeated wells were set in each group. Cells were cultured for 24, 48, 72the con-transfected group (Girdin-KO+miR-101 inhibitor) and the negative control group (NC). The results showed that Girdin had been successfully silenced in HepG2 cells while down-regulation of miR-101 significantly restored the Girdin expression level. CCK-8 assays ([Fig. 5C](#f5-molce-39-2-96){ref-type="fig"}), scratch ([Figs. 6A and 6B](#f6-molce-39-2-96){ref-type="fig"}) and transwell analysis ([Figs. 6C and 6D](#f6-molce-39-2-96){ref-type="fig"}) were performed to test the proliferation, migration and invasion abilities of HepG2 cells *in vitro*. The results showed that knockout of Girdin expression also remarkably suppresses proliferation, migration and invasion abilities of HepG2 cells while down-regulation of miR-101 significantly restored the inhibitory effect, suggesting that miR-101 suppressed HCC development by mainly targeting Girdin.

DISCUSSION
==========

In recent years, increasing evidence suggests that the dysregulation of miRNAs participates in many types of cancer and the abnormal expression of miR-101 is closely related to


the progression of many tumors. [@b20-molce-39-2-96] confirmed that miR-101 inhibits angiogenesis of cholangiocarcinoma by directly regulating the VEGF mRNA. Another study found that miR-101 suppresses the proliferation of thyroid papillary cancer cells through targeting Rac1 ([@b9-molce-39-2-96]). However, miR-101 also has been reported to increase pulmonary adenocarcinoma cell sensitivity to cisplatin by activating caspase 3-dependent apoptosis ([@b19-molce-39-2-96]). The functions of miR-101 in HCC also have attracted an increasing amount of attention. [@b15-molce-39-2-96] examined the expression levels of 308 kinds of miRNA in HCC tissue and found that miR-101 expression in HCC tissue was significantly lower. miR-101 exerts pro-apoptotic function through its target Mcl-1 in HCC ([@b15-molce-39-2-96]). However, the specific molecular mechanism of miR-101 in HCC remains to be elucidated.

In this study, miR-101 expression level in HCC tissue detected viasevere and often life-threatening forms of Pseudomonas aeruginosa or other infections, such as Ventilator-Associated Pneumonia (VAP), sepsis or soft tissue infection. Such infections also may affect burn victims, severely burned victims, cancer and transplant patients who are immunosuppressed, and cystic fibrosis patients, Intensive Care Unit (ICU) patients or generally all hospitalized patients.
Generally, the expression of soluble OprF/I fusion protein in E. coli leads to the formation of non immunological aggregates and misfolded variants. According to Worgall et al. (Worgall S et al., Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in The Capsid., J. of Clinical Investigation, 2005, 115(5), 1281-1289) it is assumed that the native OprF protein has one disulphide bridge from Cys200 to Cys209 of SEQ ID NO: 1 and two free


Computed tomographic evidence of hepatic portal venous gas after blunt abdominal trauma does not necessitate surgery.
Historically, hepatic portal venous gas (HPVG) seen on abdominal radiographic examination indicated serious intra-abdominal pathology requiring urgent operative intervention. The mortality attributed to HPVG is associated closely with its causative source rather than a direct effect of the presence of venous air and, therefore, the finding should be correlated with a careful clinical examination before any therapeutic endeavor. Fourteen cases of HPVG associated with blunt trauma have been reported over the past 20 years, and only half of these have resulted in surgery. We report the case of a 24-year-old woman who presented with no abdominal pathology other than HPVG after a severe motor vehicle crash. She was managed nonoperatively and made aof treatment they utilize. Misconceptions about methadone and ambivalence toward methadone treatment have been well documented \[[@b36-ijerph-06-00787],[@b37-ijerph-06-00787]\]. In qualitative studies, opiate-dependent IDUs, particularly those not in treatment, generally report negative attitudes toward methadone \[[@b35-ijerph-06-00787],[@b38-ijerph-06-00787]\]. Perceived negative side-effects of methadone, a dislike for the rigid requirements demanded by MMT and fear of withdrawal from methadone upon incarceration or involuntary discharge are also reported by opiate-dependent individuals as reasons for not entering MMT \[[@b35-ijerph-06-00787]\]. Common negative beliefs about methadone include the views that it is harmful to teeth and bones, that it is more damaging to health than heroin, and that withdrawing from methadone is nearly impossible \[[@b30-ijerph-06-00787]\]. Negative attitudes toward methadone can lead many patients to leave MMT programs prematurely \[[@b30-ijerph-06-00787]\], which can result in relapse to heroin use


respectively in 2005. Most traffic accidents were caused by drivers, especially those with driving experience less than 3 years. Traffic accidents occurred on suburban roads accounted for 60%. The mortality rate of the traffic accidents per 100 km on the first grade road ranked the highest. The mortality rate of the traffic accidents on expressways ranked the highest, with continual increase of death and injury. At present, the increase trend of traffic accidents and casualties in China has been slowed down to some extent and shows a declining tendency, but the situation is far away from being optimistic. In order to cut down the number of traffic accidents and casualties, we should pay more attention to training and managing drivers with less than three driving years and thoseoperation performed in England. Clearly this setback did not permanently dampen women's enthusiasm for breast enhancement surgery.

"2013 saw the greatest rise in cosmetic surgery since the onset of the recession with double digit percentage increases in all procedures across the board. Patient confidence and also consumer confidence has returned with Britons choosing to spend on procedures with a proven track record such as liposuction which remains the gold standard for body contouring. The rise of cosmetic surgery includes statistics from right across the UK as well as representing the whole spectrum of ages as each of the different procedures are undertaken by a totally different demographic," commented BAAPS President London Plastic Surgeon Rajiv Grover.

He added, "The continued double digit rise of cosmetic surgery underlines the fact that whether


that you let the two professors fight it out among themselves. That could result in a good result for you, and probably not a worse one. Professors sometimes don't mind behaving badly in front of students, but are less likely to with colleagues. Collegiality is still valued in most places. If it needs to get escalated, let the new advisor do it also, on your behalf.

A field effect transistor using a nitride-based Group III-V semiconductor epitaxial substrate (hereinafter referred to as “GaN-FET”) is a field effect transistor constituted such that a GaN layer drives as a channel layer, and it is an element which rapidly becomes widely noticed of late from that the GaN-FET has high voltage resistance, high heat resistance and small environmental load of constituent materials as compared with the conventional FET having a structure that an epitaxial semiconductor crystal layer such as GaAs, AlGaAs, InGaAs, InGaP and AlInGaP is used as a channel layer.
The GaN-FET has various types in view of the structure of an operating layer. In particular, the GaN-FET of the type that a two-dimensional electron gas (hereinafter referred to as “2DEG”) induced in the neighborhood of the


first buffer layer or the second buffer layer, even though a channel is electrically depleted by applying voltage to a gate electrode, current flowing between the source electrode and the drain electrode is not completely shielded. This leads to the problems of deterioration of pinch-off characteristics and increase in drain leakage. Furthermore, the unnecessary current component has low mobility different from 2DEG. As a result, in the case of operating the gate electrode with high frequency voltage, adverse influence such as frequency dispersion is involved. Additionally, the unfavorable unnecessary current also flows into adjacent other elements, causing the interference such as fluctuation of threshold voltage of the adjacent elements.
To avoid the above-described various problems caused in FET, it is effective to insulate the first buffer layer, the secondthe man himself – not tall, but with a topknot that seems to take up a lot of space – cracks jokes frequently, and freely unspools his many neuroses to a stranger. “Two days ago I was with my TV animation team in post-production having a recording meeting and I was very upset,” he volunteers while settling into a squeaky black leather swivel chair. “I said, ‘Hey, producer, I told you that before the meeting I wanted an agenda. And then I never received it.’ Then some people said, ‘Hey, Takashi. You already sent us an agenda. So we were wondering why you were so upset.’ ” He laughs. “This is a very ordinary situation for me. My memory is nothing.” He goes on: “When I get an


The background description provided herein is for the purpose of generally presenting the context of the disclosure. Work of the presently named inventors, to the extent it is described in this background section, as well as aspects of the description that may not otherwise qualify as prior art at the time of filing, are neither expressly nor impliedly admitted as prior art against the present disclosure.
In wireless communication systems, multiple-input and multiple-output (MIMO) refers to an use of multiple antennas at both a transmitter and a receiver to improve communication performance. MIMO technology has attracted attention in wireless communications, because MIMO offers significant increase in data throughput and link range without additional bandwidth or increased transmit power. MIMO achieves this by, for example, spreading the same total transmitWednesday, July 29, 2009

55. The Man Who Loved Books Too Much: the True Story of a Thief, a Detective, and a World of Literary Obsession, by Allison Hoover Bartlett

There are many kinds of book collectors. Some collect a particular author or subject matter, some incunables and others modern first editions. Most are rational, law-abiding citizens. But sometimes the urge to collect becomes an obsession, as with Sir Thomas Phillipps' desire to own a copy of every book in the world. (I highly recommend A.N.L. Munby's Portrait of an Obsession, a distillation by Nicolas Barker of the five volumes of Phillipps Studies.) And sometimes, as with John Gilkey, the subject of Ms. Bartlett's book, it causes the collector to turn to crime.

Gilkey was (is?) a book thief. He seems


these issues? What is the interplay between property rights and personalty rights and privacy? What effect does the institutional claim of copyright over images that are likely public domain have on future use? These are questions the answers to which concern us all, because they will have an impact on the availability of information. An example from my own recent reading comes to mind. I had read a non-fiction book about a Caravaggio painting, and commented negatively on the absence of images. How, I wondered, was it possible to write a book about a piece of art without showing us that art? I think now that it is quite likely that permission to use images of the work was denied. If that is the case, then I canflush of the fire and the cider in his cheeks."

Suffering is relative.

This is a stunning debut novel, well-researched, with characters who are psychologically believeable. The portraits Houghteling draws of Paris in the days before and after the fall of Paris have the absolute ring of truth.

Friday, July 3, 2009

"The following day, no one died." Thus begins this odd little book in which Saramago imagines what happens in a country in which no one dies. People who should die remain just this side of death. At first, the country rejoices. Death is vanquished! But then reality sets in. Who will care for those who ought to be dead? What will become of undertakers, and the issuers of life insurance policies? The Catholic Church realizes that if there is no


But given the fact that energy bars are a multi-million dollar industry and prime Instagram bait, it makes sense that Soylent would want to venture into the world of solid food again. The bars, which come in three flavors; chocolate brownie, salted caramel and citrus berry, are currently only available online. A pack of 30 snack bars costs $30.

The new Soylent Squared bars, unlike the company's 14-ounce shakes, aren't meant to replace a meal by themselves. In a press release, Soylent CEO Bryan Crowley said that Soylent Squared is meant to allow consumers to "portion out the nutrition they need." Either consume one or two bars for a snack, or eat three or four for a meal replacement.

Nutritionally, the Soylent Squared bars are definitely a safer bet thansuccessfully crowd-funded last year, is somewhat unusual. It completely escaped my notice, proving that I don't have the encyclopaedic knowledge of every cyberpunk game ever published that I like to claim (if anyone would like to send me a copy of Underground or that French game about underwater colonies, I haven't read them either...). Accessible Games was kind enough to send me a PDF copy for review.Psi-Punk is based on Fudge, an open system best known these days as the basis of Fate. Fudge already has at least one well regarded cyberpunk conversion, and a DIY ethos which appealed to a certain sort of open-culture advocate cyberpunk fan back in the day. Back in the days when I would bore the Cyberpunk 2020 forum community complaining about complex


for destroying the tapes?"

Haspel: "Senator, I absolutely was an advocate if we could within and conforming to U.S. law and if we could get policy concurrence to eliminate the security risk posed to our officers by those tapes and—"

Feinstein: "You’re aware of what those tapes contained?"

Haspel: "No, I never watched the tapes, but I understood that our officers’ faces were on them and that was very dangerous at a time when there were unauthorized disclosures that were exposing the program."

It’s easy to see how security concerns would influence the decision to wipe out evidence of the interrogations. But some CIA watchers pointed to a CIA email suggesting a less virtuous motive at play: The exchange describes Rodriguez as having expressed concern that publication of the videos could damage<?xml version="1.0" encoding="utf-8"?>
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Data storage systems are arrangements of hardware and software that typically include one or more storage processors coupled to arrays of non-volatile data storage drives, such as magnetic disk drives, electronic flash drives, and/or optical drives. The storage processors service host I/O operations received from host machines. The received I/O operations specify one or more storage objects (e.g. logical disks or “LUNs”) that are to be written, read, created, or deleted in accordance with the received I/O operations. The storage processors run software that manages incoming I/O operations and performs various data processing tasks to organize and secure the host data that is received from the host machines and then stored on the non-volatile data storage devices.
Some previous data storage systems have provided traditional RAID (Redundant Array ofIntroduction
============

Despite ongoing efforts to improve diagnosis and treatment, cancer continues to claim over eight million deaths per year worldwide.[@b1-cin-14-2015-163] Two dominant approaches have been cited[@b2-cin-14-2015-163] to improve outcomes: (1) earlier detection and (2) improved treatment personalization.[@b3-cin-14-2015-163],[@b4-cin-14-2015-163] A focus on earlier detection stems from recent studies observing that earlier detection[@b5-cin-14-2015-163],[@b6-cin-14-2015-163] can improve outcomes \>30%. A focus on treatment personalization stems from the recognition that therapeutic approaches, highly effective in some patients, may have little or no benefit to other patients seemingly with the same tumor type.[@b7-cin-14-2015-163] Consequently, tools to correctly assign patients to treatment plans are critical. Ideally, relatively cheap, highly accurate, blood bio-marker-based diagnostic tests could help diagnose disease and subsequently manage treatments.

Biomarker discovery approaches attempt to find proteins that are (1) relatively unique to the tumor, (2)


survival but not for proliferation, and a necrotic region Ω*~N~* in which nutrients are insufficient for survival. The tumor growth velocity (nondimensionalized) is implemented via a generalized Darcy's law[@b63-cin-14-2015-163]: $$\mathbf{v}_{c} = - \mu\nabla P + \chi_{E}\nabla E$$where *m* is a cell mobility representing the net effects of cell--cell and cell--matrix adhesions, *P* is an oncotic pressure, *χ~E~* is a haptotaxis, and *E* is an extracellular matrix (ECM) density. Definitions for *χ~E~* and *E* are in Ref. [@b63-cin-14-2015-163]. By assuming that the cell density is constant in the proliferative region, the overall tumor growth is associated with the rate of volume change: $$\nabla \cdot \mathbf{v}_{c} = \lambda_{p}$$where *λ~p~* is a nondimensional net proliferation rate (see later). Here, the cell density is assumed not to exceed 70% of the totaltissue, with the remainder composed of ECM. Tumor growth was simulated to Day 18 after inception, which allowed for reasonable computational cost (longer times will be explored in future work).

### Angiogenesis

The vasculature model component is inspired by Ref. [@b64-cin-14-2015-163] and based on Refs. [@b22-cin-14-2015-163] and [@b63-cin-14-2015-163], representing blood flow, vascular leakage, and vascular network remodeling due to wall shear stress and mechanical stresses imposed by the tumor tissue. The vasculature model is described in detail in Refs. [@b22-cin-14-2015-163] and [@b63-cin-14-2015-163]. The main model parameters influencing vascular flow include blood vessel pressure, vessel radii, vessel wall hydraulic conductivity, and osmotic pressure difference, with values set from previously reported experimental work.[@b22-cin-14-2015-163] We simulate a simplified lung capillary organization composed of square elements, acknowledging that in reality the capillaries are heterogeneously


fractionation was carried out on a POROS R2 column (4.6650 mm; Applied Biosystems) using trifluoroacetic acid/acetonitrile as a buffer system (solvent A: 95% H~2~O, 5% acetonitrile, and 0.1% trifluoroacetic acid and solvent B: 90% acetonitrile, 10% H~2~O, and 0.1% trifluoroacetic acid) at a flow rate of 2.7 mL/min. The gradient was 5% solvent A until the absorbance reached baseline (desalting step) and then 5--50% solvent B for 18 minutes, 50--80% solvent B for seven minutes, and 80--95% solvent B for two minutes. During the run, 72 900-mL fractions were collected. Each fraction was individually digested in solution with trypsin (400 ng/fraction), and the fractions were grouped into eight pools based on chromatographic features, corresponding to a total of 96 fractions for analysis from each experiment.

### Protein identification andplasma membrane and is intended to annotate gene products that are not tightly attached to the cell surface. Therefore, proteins annotated with *extracellular* are basically proteins *secreted* into the medium. In cases that an IPI had multiple locations, the protein was considered extracellular as long as one annotation was *extracellular space*. The protein masses were segregated matching the nonlinear separation of diffusivities in the simulations ([Table 1](#t1-cin-14-2015-163){ref-type="table"}), ie, using a factor 3.76 to define the ranges. Accordingly, five size categories were defined: high (3,816,030--1,014,901 Da), medium-high (1,014,901--269,920 Da), medium (269,920--71,787 Da), medium-low (71,787--19,092 Da), and low (19,092--32 Da).

Results
=======

Evolution of tumor growth in time
---------------------------------

The simulated tumor begins within normal host tissue as a small avascular nodule (\<100 µm) surrounded by normal (capillary) vasculature ([Fig. 1A](#f1-cin-14-2015-163){ref-type="fig"}). Even though the nascent


diameter ([Fig. 1B](#f1-cin-14-2015-163){ref-type="fig"}), surrounded by numerous angiogenesis-induced capillaries. By this time, there are substantial levels of proliferative tissue-, hypoxic tissue-, and necrotic tissue-related proteins shedding into the vasculature.[@b22-cin-14-2015-163],[@b63-cin-14-2015-163]

[Figure 2A](#f2-cin-14-2015-163){ref-type="fig"} quantifies the fractions of proliferative, hypoxic, and necrotic tumor tissues from inception (Day 0) through Day 18, at which time 49% of the tissue is proliferative, 18% of the tissue is hypoxic, and 33% of the tissue is necrotic. After Day 6, the angiogenesis-induced supply of nutrients stabilizes the change in the tumor cell fractions, as noted by the smoother curves in [Figure 2A](#f2-cin-14-2015-163){ref-type="fig"}, which is consistent with previous experimental observations showing the stabilization of tumor-induced vasculature by Day 6 after inception.[@b76-cin-14-2015-163] The ratio of neo- and pre-existing vasculature to tumor tissue during the course of growth is shownprotein measured experimentally for the low-mass cases, which was much lower, and hence did not follow the exponentially increasing trend set by the other sizes ([Fig. 8B](#f8-cin-14-2015-163){ref-type="fig"}). This suggests that low-mass intracellular proteins may have difficulty in shedding into circulation beyond what can merely be attributed to diffusion -- an effect that would have to be further analyzed in order to account for it in the computational model.

Discussion
==========

Biomarker discovery approaches assume that genomic alterations that influence disease-associated protein expression are driven by pathophysiological cell or tissue changes. However, the way these changes can influence the protein excretion from cells, diffusivity in the interstitium, and persistence in blood circulation is not well understood. In particular for cancer, the effects of tumor size, architecture, cell composition, and cell states in


 1.5 ([\*](#tfn1-cin-14-2015-163){ref-type="table-fn"})                                           [@b63-cin-14-2015-163]
  Oxygen uptake rate by hypoxic tumor cells                              1.3 ([\*](#tfn1-cin-14-2015-163){ref-type="table-fn"})                                           [@b63-cin-14-2015-163]
during crash or fall situations. No such guarantee is given or should be perceived.

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the wk before (not from out door camping ) he's on his second one!,, the more you ask around the more problems there seems to be with this product not sure how they got a good reputation (Posted on 11/03/2015)

Great camera. Delivery options wereReview by Joanna J.

Overall rating

Great camera. Delivery options were flexible which made it easier to organise while I was working. (Posted on 08/03/2015)

Stress free purchaseReview by Linda B.

Overall rating

As this product was a birthday present for my other half, and as I'm a so called 'last minute person', it has arrived on time and even day earlier than first estimated! So five starS there!Although he has not used it yet so I cannot write anything with regards The product itself, but I'm sure that aArmed with some of the top young players in the NHL, the Toronto Maple Leafs ended a three-year Stanley Cup Playoff drought by finishing as the second wild card from the Eastern Conference last season.

Led by center Auston Matthews, the No. 1 pick in the 2016 NHL Draft, the Maple Leafs had three of the top four rookie scorers in the League last season. Matthews, who won the Calder Trophy, was first with 69 points (40 goals, 29 assists). Forwards William Nylander (22 goals, 39 assists) and Mitchell Marner (19 goals, 42 assists) finished tied for third with 61 points each.

[RELATED: Complete Team Reset coverage]

With teams having a better idea of what to expect from the Maple Leafs' talented young core this season, the road to the playoffs


conduct's prohibition on lobbying the NSW government for 18 months upon leaving office.

However, he said that given the club is in Queensland, he could not foresee a circumstance under which this would happen.

Mr Annesley gained an early profile by raising the issue of sports gambling in his inaugural speech to Parliament.

He voiced his concern at the ‘‘enormous growth of gambling on sporting events and specifically the relatively recent advent of more exotic bet types, previously unavailable’’.

This type of betting was ‘‘potentially the most significant threat to the integrity of sport we have ever confronted’’.

Last year, Mr Annesley oversaw the introduction of laws which impose jail sentences of up to 10 years for match fixing, race fixing and other forms of corruption in sport.

Mr Annesley was appointed to cabinetquarantine ([@R18]). But in the nineteenth century, another, even more frightening scourge, cholera, was approaching ([@R20]). Cholera emerged during a period of increasing globalization caused by technological changes in transportation, a drastic decrease in travel time by steamships and railways, and a rise in trade. Cholera, the "Asiatic disease," reached Europe in 1830 and the United States in 1832, terrifying the populations ([@R21]*--*[@R24]). Despite progress regarding the cause and transmission of cholera, there was no effective medical response ([@R25]).

During the first wave of cholera outbreaks, the strategies adopted by health officials were essentially those that had been used against plague. New lazarettos were planned at western ports, and an extensive structure was established near Bordeaux, France ([@R26]). At European ports, ships were barred entry if they had "unclean


Let's get this straight: the so-called RoastBusters who were the subject of a 3 News report last night are rapists. I'm hardly the first to say this: people in their own social networks seem to have been telling them the same for at least a year.

I discovered today that a friend's teenage daughter had encountered them. They tried to make her get into the boot of a car. She didn't, and she told her mum about it. Their actions might have been news to most of us last night, but it appears that they're known amongst their own. And that will be just as they like it.

Are these young men performing acts they've seen in pornography? Yes. But there's more to it than that. They're narcissists and bullieswe have done cause if it hasnt hurt you then fuck off.. Before the roast busters page and videos.. Roast busters were already knowen by every, It wasn't us that talked about it. It was your friends and your friends friends.. We didnt expect to get out there as much as we did but it happen and now you're blaming us for it? Why?

As a number of commenters point out, there's a palpable homoerotic element to this. They're a bunch of young guys who like to get their cocks out together. And that's okay. What's not okay is them deliberately getting younger girls (sometimes under 16) intoxicated past the point of any consent, gangbanging them and then humiliating them as sluts for their Facebook audience. Rape is not


On Thursday, the largest member of Airbus’ A350 wide-body family, the A350-1000, took its first flight out of its manufacturing facility in Toulouse, France. The A350-1000 is equipped to carry 366 passengers in a standard three-class configuration or a maximum of 440, and boasts a range of 7,950 nautical miles. Expected to enter service with Qatar Airways next year, the A350-1000 is approximately seven meters longer than the A350-900, and has received nearly 200 orders to date. The aircraft is powered by Rolls-Royce Trent XWB-97 engines, and Airbus reports that it is 20 tons lighter and 25% more fuel efficient than its main competitor, Boeing’s 777. Airbus President and CEO Fabrice Brégier said, “we have seen today the world’s most modern and efficient passenger aircraft – the A350-1000Meek Mill is now saddled with something bigger than himself. From the moment he helicoptered out of Pennsylvania’s Graterford Correctional Facility in April of this year after being imprisoned for a parole violation, he embraced his role as a poster child for criminal justice reform. “It’s a shame that model probationers can be immediately put back behind bars simply for missing curfew, testing positive for marijuana, failing to pay fines on time or, in some cases, not following protocol when changing addresses,” he wrote last month in a New York Times op-ed, imploring lawmakers to pass legislation granting reductions in probation time for good behavior.

These concerns aren’t foreign to Meek’s music. All of his projects have told the story a man who, because of where he was raised,


in the face. Father, who was with Shackelford at the hospital, attempted to calm and restrain her. Later, father spoke with Joehnk and pleaded with him to understand Shackelford's emotional background and not to "take to heart what had just transpired."
One or two days later, SCF caseworkers visited Shackelford and father at the hospital and expressed concerns for the safety of S because of Shackelford's inability to care for her older child, A. Among other things, Shackelford was unable to supervise A, had abused alcohol, and had been unable to protect A from a man who was a danger to him. Additionally, Shackelford had tested positive for THC (marijuana) during her pregnancy with S. SCF also was concerned because "[t]he child's father fails to recognize the risk ofdisorder, when combined with his PTSD, "caused him to be a risk for a small child." Lastly, Basham noted that father's relationship with Shackelford exacerbates his mental health problems. After reviewing Basham's report, Sierzega informed father, in a letter, that SCF expected him to complete a drug and alcohol evaluation within 30 days and to obtain a urinalysis within 24 hours, and that failure to meet those conditions could result in the filing of a petition to terminate his parental rights. In response to the letter, father scheduled a drug and alcohol evaluation, but he failed to appear at the appointed time and date.
In December 1998, SCF filed a petition to terminate father's parental rights. At the termination hearing held in August 1999, father testified that he was


cards are manufactured the same, and the optical transceiver module with the desired wavelength (e.g. 850 nm, 1310 nm, 1550 nm, coarse wave division multiplexed (CWDM), dense wave division multiplexed (DWDM), etc.) is plugged in as a function of the specific application or development configuration. Network operators and service providers have adopted optical transceivers to reduce sparing costs. Further, significant cost reductions are realized by MSA standardization of optical transceivers because of multiple independent manufacturing sources. The MSA specifications tightly define the mechanical characteristics, management interfaces, electrical characteristics, optical characteristics, and thermal requirements of optical transceivers. Advantageously, this enables interoperability among equipment vendors of optical transceivers, i.e. any MSA-compatible optical transceiver can be used in any host system designed to the MSA specification; however, these tightly defined characteristicsfour over-the-counter sleeping pills and fell asleep well after midnight. He still didn’t know.

The couple -- who considered themselves free spirits and shared a love of horror movies -- had been together for nearly three years. Reyes said Kaufman engaged everybody he met in conversation, often holding up the grocery store check-out line. He refused to get a driver’s license, saying he didn’t want to give up the daily rides to and from work with Reyes.

Kaufman, who was adopted by an aunt and uncle after his parents died, spent much of his childhood in Pasadena but moved to Rialto during high school.

He had worked at the social services center for about five years.

Thursday morning at Reyes’ house in Rialto, where he lives with his parents, he waited for


reasons why the DVOA system isn't impressed by Minnesota's play so far:

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Every week, the Vikings' Week 1 loss looks worse as the 49ers play like garbage and the opponent adjustments gradually get stronger. As of now, the single-game DVOA for that loss is -84.3%. We've never seen any evidence that DVOA works better if we throw out each team's worst game or anything like that. That game counts.

The Vikings beat Kansas City in Week 6 despite gaining just 4.7 yards per play with a 33 percent success rate. We covered the kooky numbers from this win last week.

Those are just two of the bad teams Minnesota has played this year. The Vikings have played the easiest schedule in the league so far, thanks to two gamesagainst Detroit. Even the loss to Denver doesn't look any better to DVOA because, as detailed above, Denver doesn't have the rating you would expect from an undefeated 6-0 team.

The Vikings have also gotten the bounces. They've recovered 5 of 8 fumbles on offense and all 4 of the fumbles they've caused on defense.

The schedule strength issue is also part of the massive disconnect between Football Outsiders' advanced stats for Teddy Bridgewater and ESPN's Total QBR. But only a small part. We currently have Bridgewater ranked 25th in passing DVOA, but ESPN has him ninth in QBR. But the gap between Bridgewater's DVOA and VOA is very small, less than two percentage points.

I talked to some folks from ESPN to try to figure out where the difference is,


and there's really no clear explanation I can give. Figuring this out will likely take going deep into the difference between the two ratings systems on individual plays. We know that Bridgewater has been outstanding on third downs this year, but that should be picked up by both stats systems. Bridgewater's passing DVOA goes from -22.3% on first and second down to 6.5% on third and fourth down. The difference is even bigger in QBR, where Bridgewater is fifth in the league with 83 QBR on third downs, because QBR includes both running and passing plays. Bridgewater has a first down on four of his six third-down scrambles.

Bridgewater does get a little value in QBR because of Vikings have drawn a lot of penalties by opposing defenses without25–35 . The activation of EGR-1 by nicotine contributes to up-regulating the expression of cyclinD1 and its phosphorylation. Our immunohistochemistry results indicate that Aβ 25–35 can increase the phosphorylation of ERK1/2, and this process can be blocked by nicotine administration. Last but not least, the protein level of EGR-1 was significantly decreased by nicotine treatment which was up-regulated by Aβ 25–35 . In this study, we elucidated the partial mechanisms that underlie the activation of EGR-1 by nicotine, and provide theoretical knowledge for retarding the proceeding of AD.

Materials and Methods Antibodies and Chemical reagents The antibodies against ERK1/2, Thr202/Tyr204 phospho-ERK1/2, cyclinD1, Thr286 phospho-cyclinD1 were from Cell Signaling Technology; Nicotinic acetylcholine receptor α7 was from Abcam; EGR-1, and β-actin were from Santa Cruz Biotechnology. U0126 was from Cell Signaling


_________________"We come to love not by finding a perfect person but by learning to see an imperfect person perfectly."

cherebi

Location : NYPosts : 1310Join date : 2009-07-11

Subject: Re: Dragon Nest Wed May 18, 2011 11:17 am

Basically, like Maple and Vindictus combined.. Maple characters are cartoonish and 2D.. Vindictus gameplay is 3D, need the use of camera instead of just side-scrolling.. The usage of combo is similar to those in DFO.. That's all I see it..

Characters:There will be 4 characters, classes are basically the same as classes is maple.. Characters are gender-locked like Vindictus does.. (based on vids that I've seen)

*Warriors = melee characters, same thing as warriors in maple.. You just get close to monsters and whack them with your combo.. Character is male..Weapon choice: greatsword, hammer, axe

*Archers =prostitutes to their hotel rooms, leading to the dismissal or resignation of several agents. In 2014, the agency failed to prevent an armed guard working for a private security agency from riding in an elevator with Mr. Obama, a violation of Secret Service protocols. Days later, a knife-wielding man scaled the White House fence, ran across the lawn and entered the building before agents stopped him.

Subsequent investigations into the agency revealed several instances of people slipping through security screening and getting close to the president. After Representative Jason Chaffetz, Republican of Utah, became a prominent critic of the agency, it emerged that dozens of agents had improperly gained access to his 2003 application to be a Secret Service agent, and that at least one official had suggested leaking


Sub
Section (1) of Section 22 of the Industrial Disputes Act, 1947, we hereby
notify that all the Postal/RMS/MMS/Administrative & Postal Accounts
Employees and the Gramin Dak Sewaks (NFPE) will go on 1 DayStrike on 15th
February,2017.

1. Settle the demands raised by NJCA
regarding modifications of 7th CPC recommendations as submitted
in the memorandum to Cabinet Secretary on 10th December 2015.
(See Annexure-I). Honour the assurance given by the Group of Ministers to NJCA
on 30th June 2016 and 6thJuly 2016, especially
increase in minimum wage and fitment factor. Grant revised HRA at the existing
percentage itself i.e. 30%, 20% and 10%. Accept the proposal of the staff side
regarding Transport Allowance. Settle all anomalies arising out of
implementation of 7th CPC recommendations, in a time bound
manner.

2. Implement option-I recommended by 7th CPC
and accepted by the Government regarding parity inTHE SELF-RESPECT AND DIGNITY OF 33 LAKHS CENTRAL GOVERNMENT EMPLOYEES AND 34 LAKHS PENSIONERS.

ABOUT 15 LAKHS CENTRAL GOVERNMENT EMPLOYEES AND AUTONOMOUS BODY EMPLOYEES WILL PARTICIPATE IN THE STRIKE

vCentral Government employees and Pensioners betrayed by NDA Govt. by breach of assurance given by Group of Cabinet Ministers including Shri Rajnath Singh, Shiri Arun Jaitely and Shri Suresh Prabhu regarding increase in Minimum Pay and Fitment formula. This is the worst pay revision after 2nd CPC report in 1960. Government implemented the report without any modification suggested by Staff side (JCM). In 1960 entire employees went on five days strike.

vCentral Government Pensioners and Family Pensioners betrayed by NDA Government by not implementing Option-I (parity) recommended by 7th CPC and accepted by Cabinet.

vAutonomous bodies employees betrayed by NDA Government by issuing


but no negotiated settlement with the JCM (NC) staff side on any of the issue, but only one-way hearing of the views of the staff side. Implementation Committee, Empowered Committee, Allowances Committee, Pension (Option-1) Committee, Anomaly Committee, New Pension System (NPS) Committee and Senior officers Committee (?) to discuss the issues arising out of 7th CPC recommendations. (no formal orders constituting the Group of Senior Offices Committee and no terms of reference made public). Almost six months are over after Cabinet approving pay scales and one year is over after submission of 7th CPC report, but no outcome of any committee).

On the night of 30th June 2016, Shri Suresh Prabhu, Hon’ble Minister for Railways informed the Secretary, JCM (NC) Staff side Shri Shiv Gopal Misra that the Prime(Fig. \[fig:poynting\]), so the largest amount of bending-induced twisting becomes $\Delta \gamma \approx 0.13 \times \Theta^2$, which turns out to be only $\Delta \gamma \sim 0.1$ % even at bending as large as $\Theta=10$ %. A CNT with $D=1$ nm bent to $\Theta=1$ % would then need to be at least a quarter of a millimeter long to twist a full turn. Being this tiny in magnitude, bending-induced twisting could not be resolved in periodic simulations. Zhao and Luo[@Zhao2011a] reported twisting-induced bending, but it was due to the Poynting effect combined to a constrained length for a finite tube; *intrinsic* bending-induced stretching in CNTs seems to be too minor to be of practical significance.

Deformed MS and A nanowires
===========================

Electromechanics of Mo$_6$S$_6$ nanowire
----------------------------------------

Let us next leave CNTs aside and move to studying MoS$_2$ monolayer -derived  nanowires.[@Seifert2000; @ghorbani-asl-SC_2013;


$12$-atom cell  was stable at least beyond $\Theta=\gamma>4$ %, as shown above (lower right panel in Fig. \[fig:mos\]b). When the simulation cell length was extended to $2.6$ nm, however, atomic structure revealed its sensitivity to combined deformations. When twisted, the elastic energy first depended quadratically on $\gamma$ with the torsion constant $150$ eVÅ, in fair agreement with the literature.[@Leen2015] Upon further twisting the energy started to deflect from this quadratic trend and the wire began to yield (inset of Fig. \[fig:stability\]a). Most important, the deflection and yielding occurred at rapidly decreasing twist when bending increased. By plotting the yield points of twisting for different $\Theta$ it became evident that combining bending and twisting affects stability limits dramatically (Fig. \[fig:stability\]a). For example, the yield limit in purely twisted wire was $\gamma=18$ %, but modest $\Theta\sim 0.5$ % bendingIf this is your first visit, be sure to
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Images out of line in Firefox

Hi,

I'm working on a website in which I am using opacity in CSS for the content so that the background will show through. As a result any images that I place in the content inherit the opacity. As a workaround I have positioned images over the original images by creating divs outwith the content div. This works very well except that in Firefox the images are out by about 50px. Also the bottom margin does not appear in