their presence that all regulations had been followed. We conclude that under the circumstances of this case, appellants acted as soon as they "knew or should have known" of the irregularities. Appellants cannot be faulted for relying on the assurances of the District Clerk's office regarding the jury-assembling procedures and diligently pursued the error through their Motion for Mistrial as soon as the irregularities became apparent. We therefore hold that appellants' timely actions properly place the case on its merits before us.

Analysis
Because we find that Appellant did not waive his objection to the violations of the Clerk's office in assembling the jury array, we next address the merits of his first two points of error. It is undisputed that irregularities in the granting and documentation of exemptions and"hotly contested" and if the evidence is "sharply conflicting," such that complained-of errors result in a materially unfair trial. In Lorusso v. Members Mut. Ins. Co., 603 S.W.2d 818 (Tex.1980), the court, citing Tamburello and Patterson with approval, noted:
We recognize the impossibility of prescribing a specific test for determining whether any error, be it the improper admission or exclusion of evidence, improper argument, or the giving or depriving of a party of the proper number of peremptory challenges, "was reasonably calculated to cause and probably did cause the rendition of an improper judgment." Such a determination necessarily is a judgment call entrusted to the sound discretion and good senses of the reviewing court. It is clear, however, that such a judgment call must be determined from an evaluation


on the totality of the record before us, we find that the trial in the instant case sufficiently meets the standard set by the supreme court of a hotly contested trial which resulted in a materially unfair trial as a matter of law.
c. Harmful error analysis
Moreover, we would reach the same conclusion under a harmful error analysis. Texas Rule of Appellate Procedure 81(b)(1) provides:
No judgment shall be reversed on appeal and a new trial ordered in any cause on the ground that the trial court has committed an error of law in the course of the trial, unless the appellate court shall be of the opinion that the error complained of amounted to such a denial of the rights of the appellant was reasonably calculated to cause andjury. First, a party may challenge the array. Tex.R.Civ.P. 221. Generally, this objection alleges a defect in the juror selection and summons procedure or a violation of the jury-wheel statute. See TEX.GOV'T.CODE ANN. §§ 62.001-021 (West 1988 & Supp.1995). If the movant is successful, the entire array is dismissed and a new array is summoned. Tex.R.Civ.P. 222. The challenge must be presented in a written motion supported by affidavit to the particular judge in charge of the local jury system. Tex.R.Civ.P. 221; State ex rel. Hightower v. Smith, 671 S.W.2d 32, 36 (Tex.1984); Martinez v. City of Austin, 852 S.W.2d 71, 73 (Tex.App.Austin 1993, writ denied); Texas Employers' Ins. Ass'n v. Burge, 610 S.W.2d 524, 525 (Tex.Civ. App.Beaumont 1980, writ ref'd n.r.e.). See also Tex.Gov't.Code Ann. §§ 62.001-.021


errors in the selection of the jury when the complaint, as in this case, is made only after the verdict. See Pouncy v. Garner, 626 S.W.2d 337, 340 (Tex.Civ.App.Tyler 1981, writ ref'd n.r.e.); Sendejar v. Alice Physicians & Surgeons Hosp., Inc., 555 S.W.2d 879, 886 (Tex.Civ.App.Tyler 1977, writ ref'd n.r.e.); Berner v. Southwestern Public Service Co., 517 S.W.2d 924, 925 (Tex. Civ.App.-Amarillo 1974, writ ref'd n.r.e.). See also McDonald Texas Civil Practice § 21.43 (1992) ("It is the general rule that when a party or his or her attorney learns before verdict of an impropriety in the course of the trial, he or she must promptly complain or the matter will be waived."). This rule applies not only when the party is aware of the irregularity but alsothe tiles. The sheet is often first cross-cut to produce two 4′ by 4′ sections, and is then gang-ripped to produce planks. The planks continue along the conveyor and are fed into a molder, which has a series of cutters set in a straight line array in order to profile a tongue along one side edge of the plank and a groove along the opposite side edge of the plank. The pieces are then rotated by means of the conveyor and are fed into the next machine, which adds a tongue to one end edge of the plank and a groove to the opposite end edge of the plank. The resulting planks are then suitable for installation on a floor (or other surface) by fitting a tongue of


one plank into the groove of an adjacent plank.
Wood flooring is manufactured in much the same way, but solid wood flooring is generally not initially cut into standard-size larger sheets. Rather, it is milled into board widths determined by the girth of the tree from which they came. Engineered wood flooring is more similar to laminate flooring in that a surface layer or veneer of a wood species is adhered to a substrate of either plywood or a composite material, and such engineered wood flooring may be initially laid up in the 4′ by 8′ format. The machining process for engineered wood flooring is generally similar to that for laminate and wood flooring.
Manufacturing of the aforementioned tiles requires a surprising degree of precision. Tile thicknesses are of criticalproceedings are

“extraordinary events in the constitutional framework because they deprive the [affected

party] of the root requirements of due process . . . .” See also Carroll v. President and

Comm’rs of Princess Anne, 393 U.S. 175, 89 S.Ct. 347, 21 L.Ed.2d 325 (1968) (expressing

disapproval of ex parte proceedings).

       Citing In re Taylor and Carroll, in State ex rel. Bryan v. McDonald, 662 S.W.2d 5, 7

(Tex.Cr.App. 1983), the Court held that the inspection of a presentence report before a

determination of guilt violated due process. It reasoned that a court could not maintain its

status as a neutral arbiter when it considered evidence theoretically inadmissible in a court

of law and concluded that the practice of the trial judge “of reviewing prior to a

determination of guilt unsworn


data as text
Resize the columns
Move the data into the workbook from which the code is run.

The .opentext code needs to be updated depending on the number of columns in the source data.
Sub ImportCSV()

Dim vPath As Variant
Dim wb As Excel.Workbook
Dim ws As Excel.Worksheet

Set wb = Excel.ActiveWorkbook
Set ws = Excel.ActiveSheet

vPath = Application.GetOpenFilename("CSV (Comma Delimited) (*.csv),*.csv" _
, 1, "Select a file", , False)
''//Show the file open dialog to allow user to select a CSV file

If vPath = False Then Exit Sub
''//Exit macro if no file selected

Workbooks.OpenText Filename:=vPath, Origin:=xlMSDOS, StartRow:=1 _
    , DataType:=xlDelimited, TextQualifier:=xlDoubleQuote, Comma:=True _
    , FieldInfo:=Array(Array(1, xlTextFormat), Array(2, xlTextFormat), _
    Array(3, xlTextFormat))
''//The fieldinfo array needs to be extended to match your number of columns

Columns.EntireColumn.AutoFit
''//Resize the columns

Sheets(1).Move Before:=wb.Sheets(1)
''//Move the data into the End If

    Dim ws As Excel.Worksheet
    Application.Workbooks.Add
    Set ws = Excel.ActiveSheet
    Application.DisplayAlerts = False
    Sheets("Sheet2").Delete
    Sheets("Sheet3").Delete
    Application.DisplayAlerts = True

    With ws.QueryTables.Add("TEXT;" & filename, ws.Cells(1, 1))
        .FieldNames = True
        .AdjustColumnWidth = True
        .TextFileParseType = xlDelimited
        .TextFileTextQualifier = xlTextQualifierDoubleQuote
        .TextFileConsecutiveDelimiter = False
        .TextFileCommaDelimiter = True
        ''// This array will need as many entries as there will


at him, the black man with skin so dark it made his eyes glow. He said something Chico didn’t understand.

“My brother’s in there,” he said.

The man shrugged. “No habla Espanol,” he said, loudly as if he thought Chico was deaf or something. He pointed to the back of the line.

Chico let his shoulders drop and walked slowly to where the man was pointing. Kids laughed at him as he passed, calling him names and poking him when he got too close. The man turned and went back to the front.

Then he spotted him again; Francisco. He could see the side of his face past a group of little kids like him. He screwed up his face and hurled himself in between them. They yelled at him but heallow users to avoid the delay and inconvenience caused by having to wait for a caller to leave a message, listen to the message, and then attempt to return the call. Furthermore, such a system, method, and apparatus would help avoid the situation where the caller is unavailable to answer a returned call and would reduce the likelihood that the user will be unable to determine whose call he narrowly missed.
The present invention comprises a system, method, and apparatus for retrieving a telephone call that has been diverted by a telecommunications exchange from a called user telephone to a voice mail system or to some other destination. Generally, a telecommunications exchange includes a switching matrix for routing calls and a central computer for controlling the switching matrix and


   viewHolder.bigFace.setImageResource(emoji.getId());
//        }

        int id = context.getResources().getIdentifier(emoji, "drawable", context.getPackageName());
        viewHolder.bigFace.setImageResource(id);

        return convertView;
    }

    class ViewHolder {

        public ImageView bigFace;
    }
}of sequence aa when two letters picked without replacement from {o: 1, a: 7, y: 1}?
7/12
What is prob of sequence nq when two letters picked without replacement from {q: 6, f: 1, n: 2, a: 1, c: 2, r: 3}?
2/35
Calculate prob of sequence rr when two letters picked without replacement from {v: 10, r: 9}.
4/19
What is prob of sequence py when two letters picked without replacement from {y: 2, p: 2, i: 4, k: 2}?
2/45
Three letters picked without replacement from tvvvtttttv. Give prob of sequence vvv.
1/30
Three letters picked without replacement from {x: 3, a: 5, n: 4}. Give prob of sequence xnn.
3/110
Calculate prob of sequence egs when three letters picked without replacement from wswfgfgfisefggififg.
5/2907
Four letters picked without replacement from aaaagzzg. Give prob of sequence azaz.
1/70
Calculate prob of sequence


[Evaluation of the efforts in prenatal care for the prevention of prematurity].
A retrospective analysis was done in 341 singleton premature deliveries to assess the practised activities in antenatal care for the prevention of premature delivery. This analysis, expressed in terms of adequacy revealed that 56% were adequate whereas 23% were conditionally adequate and 21% were inadequate. Clinically these activities were reflected in suppression of uterine contractions (80%/57%/40%-effective tocolysis), achieved prolongation of pregnancy (25d/8d/2d) and a lowered rate of premature delivery before the 32nd week of gestation (17%/31%/33%), respectively. A prospective study depending on these results (n = 450) done in 4 centers for antenatal care (under constant supervision to keep the respective recommended activities) showed a significant reduction in the rate of premature delivery compared to a similarsame thread where users complained two weeks ago.

"Incredible! HP 1280 working!!!" crowed another user, "omarz," in a message Thursday. "I just update[d] to Snow Leopard 10.6.1 and now suddenly it was detected and it's working!" A driver for HP's PSC 1200 series was one of the 38 included in yesterday's update.

HP's Spillers recommended that users update to Mac OS X 10.6.1 before applying the separate driver update. "Make sure that the printer is turned on and connected via [a] USB cable before launching Apple Software Update," said Spillers in an e-mail reply to questions.

Spillers also said that there has been confusion about how owners of HP all-in-one devices -- which both print and scan, and in some cases also fax, documents -- get their hardware to work with


for his Senate campaign.

“Come March 31 and especially June, people are going to be weeded out on the inability to raise funds,” Reines said. “Conversely, superstars will be confirmed by money. He’ll crush it. I mean, crush it.”str(self.selected[i].text())
        for i in range(n):
            self.selected[i] = float(self.selected[i])
        print(self.selected)
    elif action == graphAction:
        self.selected = self.selectedItems()
        n = len(self.selected)
        for i in range(n):
            self.selected[i] = str(self.selected[i].text())
        for i in range(n):
            self.selected[i] = float(self.selected[i])
        print("right before plotter called")


   for i in range(n):
                self.selected[i] = float(self.selected[i])
            print(self.selected)
        elif action == graphAction:
            self.selected = self.selectedItems()
            n = len(self.selected)
            for i in range(n):
                self.selected[i] = str(self.selected[i].text())
            for i in range(n):
    therefore investigated the complementary information which come from clusters. The most interesting constraint has been found, rather surprisingly, to be the baryon fraction. Indeed with this single additional constraint we found that nearly all the cosmological parameters are well specified. Using a classical value for the baryon fraction of $\sim 15 \%$ for $h = 0.5$ we obtain as the best model: $\Omega_{\lambda} \sim 0.6$ , $\Omega_{tot} \sim 1.$, $H_0 \sim 60 $ km/s/Mpc, $\eta_{10}\sim 5.$, $n \sim 0.85$. Using a more recent result from Sadat and Blanchard, 2001, who infer a lower baryon fraction when several systematics are corrected for, we found that the best model is $\Omega_{\lambda} \sim 0.3$, $\Omega_{tot} \sim 1.1$ , $H_0 \sim 40
$ km/s/Mpc, $\eta_{10}\sim 5.$, $n \sim 0.85$ implying a high density


---
abstract: 'At low temperatures, the transport through a superconductor-ferromagnet tunnel interface is due to tunneling of electrons in pairs. Exchange field of a monodomain ferromagnet aligns electron spins and suppresses the two electron tunneling. The presence of the domain walls at the SF interface strongly enhances the subgap current. The Andreev conductance is proven to be proportional to the total length of domain walls at the SF interface.'
author:
- 'Nikolai M. Chtchelkatchev'
- 'Igor S. Burmistrov'
title: Andreev conductance of a domain wall
---

Interplay of superconductivity and ferromagnetism in mesoscopic hybrid structures is now in focus of both experimental and theoretical research. Superconductivity and ferromagnetism are two competing orders: while the former prefers antiparallel spin orientation of electrons in Cooper pairs, the latter forces the spins to align in parallel. Their coexistence in onerootkits installed, though there are tools such as rkhunter
and chkrootkit that attempt to discover these.

>Intel chips that are known to be sabotaged

Check your chip(s) against any known blacklists or whitelists that you might
have access to

>programs I can run to search for network interference?

Depends on your level of paranoia, but a sophisticated rootkit could hide
network traffic from any firewalls on your machine, so you'd need to do
monitoring with a second machine using something like Ethereal (I think it's
called Wireshark these days?)

------
staunch
Microwave on high for 20-30 minutes. Season to taste.

------
gotwalt
Soak it in water for twenty minutes. The fake identifier stickers will fall
off.

------
yen223
Step one, purchase a controlling stake in your own chip fabrication plant...


Christmas Eve Services – Christmas with Friends

Today, December 24th., there will be two services at St. Timothy’s. The Spanish language service will be held at 7p.m. with the band under the direction of Luis Sosa playing traditional & contemporary music. At 10:30 p.m. an English language service will feature special music, the chancel choir & visiting musicians under the direction of David Taylor. There will be refreshments in the parish hall after the later service. Members of the Altar Guild have worked hard to beautify the church, come & be blessed by the experience while you worship.in two different ways.
Edit:
Without all the code to debug through, it is a bit hard to pinpoint, but there is an error on this line:
file.read(&tempImageData[i*m_bmpInfo->width*3], i*m_bmpInfo->width*3);

you should not have the i* part in the amount you are reading. This means at row 200 you are reading 200 rows worth of data into the array, possibly overwriting the end of the array. once you are more than half way through the image, which is interesting given your output.


Meeting your flatbed and heavy haul needs.

With a fleet of more than 100 first-rate flatbed and heavy haul trucks and trailers, Jetco offers a diverse group of flatbed and open-deck trailers so your load can be delivered on time, no matter the size or type of your cargo. In addition, we make sure to match our equipment to your cargo to ensure its safe and secure transport.

New Trailer, Greater Capabilities.

Joining the Jetco fleet of trailers is a custom-built, 70-ton, multi-configuration trailer that we’ve affectionately named “Big Foot.” With a loaded deck height of 34” and a flat-deck length of 45’, Big Foot can handle your biggest loads.

Jetco’s drivers are TWIC and IAC compliant to facilitate the transport of airport and port cargo. Weekend, holiday and rush service isis widely utilized.[19](#jvim13797-bib-0019){ref-type="ref"}, [25](#jvim13797-bib-0025){ref-type="ref"}, [26](#jvim13797-bib-0026){ref-type="ref"} Factors influencing the increase in serum cobalamin concentration after oral administration in humans are dose and time.[19](#jvim13797-bib-0019){ref-type="ref"}, [20](#jvim13797-bib-0020){ref-type="ref"}, [21](#jvim13797-bib-0021){ref-type="ref"}, [26](#jvim13797-bib-0026){ref-type="ref"}, [27](#jvim13797-bib-0027){ref-type="ref"}, [28](#jvim13797-bib-0028){ref-type="ref"}, [29](#jvim13797-bib-0029){ref-type="ref"} A daily oral intake of 1,000--2,000 μg cyanocobalamin successfully normalized serum cobalamin in all studies available in human patients.[19](#jvim13797-bib-0019){ref-type="ref"}, [20](#jvim13797-bib-0020){ref-type="ref"}, [21](#jvim13797-bib-0021){ref-type="ref"}, [23](#jvim13797-bib-0023){ref-type="ref"}, [27](#jvim13797-bib-0027){ref-type="ref"} Continuous increases of serum cobalamin concentrations during oral cobalamin treatment have been demonstrated in several studies.[20](#jvim13797-bib-0020){ref-type="ref"}, [21](#jvim13797-bib-0021){ref-type="ref"}, [23](#jvim13797-bib-0023){ref-type="ref"}, [27](#jvim13797-bib-0027){ref-type="ref"}, [28](#jvim13797-bib-0028){ref-type="ref"} Current supplementation protocols for cobalamin in dogs call for repeated parenteral injections based on pathophysiologic justification, clinical empiric experience, and specialist opinion.[5](#jvim13797-bib-0005){ref-type="ref"}, [9](#jvim13797-bib-0009){ref-type="ref"}, [15](#jvim13797-bib-0015){ref-type="ref"} Currently, studies assessing the effect of oral cobalamin supplementation in dogs with CE are lacking. However, due to reports of successful oral cobalamin substitution in humans with various gastrointestinal disorders, one of the


work‐up including hematology, serum biochemistry, fecal examination and abdominal ultrasound. Dogs also had to have either signs compatible with CE or previously documented CE verified with intestinal biopsies. All dogs included had an initial serum cobalamin concentration ≤270 ng/L (reference 234--811), and a second serum sample for cobalamin analyses collected after institution of oral cobalamin supplementation. The cut‐off of 270 ng/L was chosen as this number represents the lowest 5% of the reference range, and dogs with signs of CE and serum cobalamin concentrations in the lowest reference range might have subtle cobalamin deficiency, as shown in a recent study.[30](#jvim13797-bib-0030){ref-type="ref"} Dogs that had previously been treated with cobalamin were included if the last cobalamin treatment was administered at the latest 30 days before a serum cobalamin of ≤270it might be argued that dogs with a serum cobalamin concentration between 234 and 270 ng/L were not truly deficient. However, hypocobalaminemia can result in severe metabolic consequences and is associated with a negative outcome.[9](#jvim13797-bib-0009){ref-type="ref"}, [16](#jvim13797-bib-0016){ref-type="ref"}, [17](#jvim13797-bib-0017){ref-type="ref"} Thus, rapid identification and early intervention is recommended.[35](#jvim13797-bib-0035){ref-type="ref"} Therefore, some centers recommend starting cobalamin supplementation when serum cobalamin concentrat‐ion is in the low reference range (see [www.vetmed.tamu.edu/gilab](http://www.vetmed.tamu.edu/gilab)). A recent study assessing MMA in dogs with different levels of serum cobalamin concentrations demonstrated that 19% of all dogs with serum cobalamin concentrations in the lower reference range had an increased MMA.[30](#jvim13797-bib-0030){ref-type="ref"} This suggests that some of these dogs were cobalamin deficient on a cellular level, and supports the recommendation to start treatment in the low reference range. It also parallels recommendations in


miraculously make their way into the daylight from
the abandoned excavation, as luck would have it, their escape occurs
above an improvised, crude desert airstrip serving the digs. The
two are within sight of the Flying Wing airplane with twirling propellers
that will soon carry the Ark to Hitler. First crouching under its
wing near the plane, Indy quickly subdues a monkey wrench-wielding
German mechanic. Then he faces a second, burly, bald and shirtless
opponent.

In an exciting sequence, the two fight and punch at
each other as the plane's pilot tries to get a clear shot at Indy
from the cockpit. Marion bashes the pilot (Frank Marshall, the producer
of the film in a bit part) over the head, and knocks him into the
throttle. His weight revs up the plane, causing it to rotate in a
circle around oneOne of the Germans orders
the Ark loaded aboard a truck to be driven to Cairo and then flown
from there to Berlin. Sallah tells them about the new course for
the Ark:

Sallah: Indy, you have no time. If you still want
the Ark, it is being loaded onto a truck for Cairo.
Indy: Truck? What truck?

From a nearby hillside, Sallah, Indy and Marion watch
the crated Ark as it is placed inside the back of a canvas-topped
truck. Nazi guards protect the truck in a caravan, with Belloq in
a staff car in front of the convoy. Indy thinks hard about what to
do next in this unpredictable situation:

Indy: Get back to Cairo. Get us some transport to
England. Boat, plane, anything. Meet me at Omar's. Be ready for
me. I'm going after that truck.
Sallah: How?
Indy: I don't


is ritualistically opened - he is greedy in
the belief that the Ark will give him and the Nazis ultimate power.
[Belloq's acquisition of 'Jewish' characteristics, and his frequent
opposing nature to the will of the Nazis may be met with the punishment
of death.] The momentous event is being documented by a film crew,
and dozens of Nazi soldiers anxiously anticipate the removal of the
Ark's lid.

The film's finale contains the most-remembered, intense
scene of all when God's fiery vengeance is visited upon the Nazis.
[The scene is reminiscent of the opening of the Great Whatsit box
in the climax of Kiss Me, Deadly (1955).]
When the gold lid is removed by two Nazi soldiers, Belloq reaches
in to discover only fine grains of sand within. (Have the stone tablets
of the ten commandments disintegrated?) But the Ark unleashesthe other crates -- other governmental
bureaucracy secrets that are being deliberately withheld, hidden,
possibly because of fear of misuse?

[In Indiana Jones and the Kingdom of the Crystal
Skull (2008), the warehouse - revealed to be in Nevada - was
revisited. The Ark itself was accidentally uncovered and visible
during a scuffle with KGB agents, but went unnoticed by the combatants.]


of historical progress (meaning that it is an “exception” to the laws and rules governing the development of other nations).The particulars attributed to the term have been said to refer to clusters of absent and present elements—the absence of feudal hierarchies, class conflicts, a socialist labor party, trade unionism, and divisive ideological passions, and the presence of a predominant middle class, tolerance for diversity, upward mobility, hospitality toward immigrants, a shared constitutional faith, and liberal individualism—that putatively set America apart from other national cultures. Although historical realities have posed significant challenge, these tenets have proven uncommonly resilient.

I take exception to America’s or any nation’s sense of exceptionalism in light of another nation’s founding documents. In the Bible, the nation of Israel under Joshua was on its way toof us, especially those who claim to be American Christians? Do we presume that God is on our side, just like soldiers of various military forces that have gone into battle throughout history with “Gott mit uns” or “God with us” (or in some other language) etched on their belt buckles, rolling off their tongues, and stirring in their hearts? I honor the bravery of America’s soldiers throughout the generations, who have put themselves in harm’s way for our democratic ideals and our society at large. Still, the presumption that we might find lurking in our souls that God is on our side does not pay honor to the commander of the Lord’s army–Jesus. The question is not to be posed to God: “What side are you on?”


[The application of pedicle orbital fat flap for the correction of lacrimal groove and palpebromalar groove deformity in the middle-aged and old people].
To explore the effective techniques for correction of lacrimal groove and palpebromalar groove deformity in the middle-aged and old people. The lacrimal groove and palpebromalar groove deformity was corrected by the techniques of transcutaneous orbital fat releasing and pedicle orbital fat flap filling. From 1996 to 2011, 426 patients, aged from 35 to 72 (average, 48), were treated by the techniques. Among them, 54 patients had underwent the surgical treatment before this operation. 362 patients were followed up for 3-24 months. Completely correction was achieved in 283 patients, obvious improvement in 79 patients. The result was not satisfied in 2 patients with severe deformity who had# main config for srs.
# @see full.conf for detail config.

listen              1935;
max_connections     1000;
srs_log_tank        file;
srs_log_file        ./objs/srs.log;
http_api {
    enabled         on;
    listen          1985;
    raw_api {
        enabled             on;
        allow_reload        on;
        allow_query


The Parliamentary Assembly of the Council of Europe (PACE) during the autumn session mayconsider a report on amending rules and procedures relating to challenging powers of national delegations, including voting rights.

“The PACE Committee on Rules of Procedure voted 10 to 9 on this issue by the end of the year, and it may well be submitted for the autumn session, including the topic of amendments to the regulation [on the abolition of sanctions articles allowing the denial of national delegations]. If such amendments are adopted, Russia may change its position on returning to PACE and send an application for participation in the assembly in 2019” said Chairman of the Committee Leonid Slutsky.

He added that the Commission appointed Petra de Sutter (Belgium) as rapporteur “not without a harsh discussion”.“This is a fairly neutral candidate for us,” the Head of the Committee noted.

The draft report might be submitted to the Commission by September 20, says the Council of Europe website in its turn. The document should reflect results of the ad hoc work of the PACE Bureau on the harmonization of the activities of the statutory bodies of the Council of Europe (the Committee of Ministers of the Council of Europe). Russia took part in the meetings of the ad hoc committee and sent its proposals on the reform of the Assembly, including questions on abolition of articles on regulations that would deprive a delegation of key powers.


Facial trauma evaluation leading to a diagnosis of delayed splenic rupture.
A patient presented 48 hours after falling and sustaining facial fractures and was evaluated in an outpatient setting. The patient had been seen at 2 other hospitals, including a level I trauma center, and discharged home. While undergoing evaluation for his facial trauma, the patient became severely hypotensive. The patient was diagnosed with a delayed splenic rupture and underwent splenectomy.Q:

How to show connections between local and remote branches in git?

I'd like to add a copy of a remote branch (origin/featureX) to my local repository.
Therefore I generated a local branch featureX and set it to track the given remote branch:
git branch featureX
git branch -u origin/featureX featureX
# Branch featureX set up to track remote branch featureX from origin.

Now is there a way to show this connection? I tried e.g. git branch -av, but no connection between featureX and remotes/origin/featureX are shown.

A:

You need to be more verbose git branch -vv, this is documented but not obvious.

-v
  -vv
  --verbose
  When in list mode, show sha1 and commit subject line for each head, along with relationship to upstream branch (if any). If given twice, print the name of the


Welcome in ZX Pest Control

ZX Pest Control is a well-established, friendly and professional company that takes great pride in providing the highest standard of pest control in Delhi NCR. Our mission is to provide pest control in a proficient manner, assuring clients of our dedication to continually enhance customer services regarding client satisfaction, quality and value for money and environmental awareness. ZX Pest Control based in Delhi, have over 400 clients nationwide.longer use wireless network anymore etc. Your IP changed, so some internet services may refuse to accept your cookies and require you to re-login.
Anyway, I think if you use default distro settings and successfully boot on your new computer, and Xorg works fine, you can shot not working anymore problems one by one, don't need to solve them until you find them.
PC is made of so many different parts mamufactured by so many companies, there's no neat solution to write a script to switch to new PC. You need to use portable configuration as possible to make your OS portable. That's how PC OS is designed.


from Сказка о тройке (Tale of the Troika) by Boris and Arkady Strugatsky. The iconic image of the three horses also appears on the Moscow’s Тройка card that is similar to MetroCard.

Бубенцы – jingle bells. If you want to listen to the Russian-language version of the classic Jingle Bells song, search for Бубенцы. A troika is incomplete without these bells.

Душа – soul. It is one of the must-know words if you want to get past the superficiality of 7-day “Highlights of Russia”-type tours. Fortunately, there is an old post on this blog that can help you understand both this word’s cultural importance and the nuances of grammar.

Тоска – a feeling of a melancholic yearning heavily spiked with regret and hopelessness. The feeling seems to be the hallmark ofsong, задаром is synonymous with напрасно (in vain). Note that понапрасну, a form of напрасно, appears in the very next line.

Жечь – to burn. Again with the classical literature here – you might come across a phrase прожигать жизнь (to waste one’s life; lit: to burn through life). Прожигать is to burn through. One can прожечь жизнь by leading an aimless, ungrounded, or chaotic life. It is also something that is associated with youth, particularly with бурная юность (tumultuous youth) and young men.

And here’s the interesting grammatical tidbit about the song. By switching from first person singular to first person plural pronouns, the song successfully avoids identifying the singer as either a man or a woman and thus can be performed by either. And now, the song along


Profondo Rosso- ...when the staging or mise-en-scène is clearly indicated." "And here they even go one step further since you can see the stage itself." "This movie has, by the way, another companion piece that was produced later:" "Stagefright, the German title is Aquarius, by Michele Soavi." "That's another movie where we can see a limited number of people in the more or less confined terrain of a theater." "But there are not only Italian films that were made in that fashion:" "The Flesh and Blood Show by Pete Walker is a British film from the 70s which also has this character." "What's interesting about that film is that everything turns out to be faked." "It's ultimately an amicable resolution that the people are actually not dead." "Thatdoesn't apply to neither Stagefright nor this film here." " Right." " Fortunately, of course." "Fortunately, yes." "We've just been granted a brief glimpse into the setting, ...everything's still lighted a little diffusely though." "And what's striking is this long carpet that is of course not unusual for a theater setting but which could be interpreted, in the context of a giallo, as a prolepsis." "Like some sort of blood trail that leads into the hall, if you will." " Explain "prolepsis"." " Okay..." "Well, we do have a very intelligent and well-read audience but of course I'll gladly explain it." ""Prolepsis" means "anticipation" or "flash-forward"." "Due to its red color, this carpet basically stigmatizes these characters." "Essentially, they're already walking on a trail of blood." " A


"Maybe we should say something about him." "I'm very familiar with Howard Ross from watching New York Ripper where he plays a potential culprit who at one time also has sex with a female protagonist, ...if you can even speak of female protagonists in that film," "...and who has this badly faked mutilated hand." " Oh, yes, yes, right." " He has this SM-sex-scene." "That film shouldn't be watched in HD." "To get back to the theater for a moment:" "If we define the theater as an "art space", which it actually is, ...it gains, of course, in the context of this somewhat decadent group here also a slightly negative connotation." "The theater is basically presented as a space for the elite that's only accessible to a specialthe room." " Yes, please." "Well, the masking with the cloak..." " ...always has this..." " The cape." "Right, the cape, which refers to this Shakespearian, classic theater look." "Yes, and these doors..." "That struck me earlier." "Here you can see it, for example." "They seem unnaturally big." "That reminds a lot of The Trial by Orson Welles, and things like that." "It gives the film a Kafkaesque touch - just to throw a real heavy word in here." " Yes." " Um, well..." "The building thereby gains a surrealistic... surreal..." " A surreal character." " ...a surreal character." "This has to be differentiated:" ""Surrealistic" means that something can be attributed to the Surrealist movement which applies to very few films." "Buñuel's Un Chien Andalou and The Golden


the viewer pigeonholes these characters, ...except for a few exceptions like "I like him", "I don't like him" "he stays unsympathetic from the start", "he's a little impenetrable", and so on," "...there's not a very big development." "That's not untypical for this kind of film, though." "A complex character-painting is more of a rare occurrence." "I think that's very important." "The characters reflect our position as the viewer." "Which means they also reflect what we could or should feel." "So when she approaches him now, telling him she's scared then that's something the mise-en-scene also demands from us." "The uncertainty the viewer experiences is addressed here in this dialogue." "Which makes her the main protagonist." "Or at least the person you identify with." "In this scene and actuallyYes." " A hint of Edgar Allan Poe again." "How did it go? "The death of a beautiful woman is the most poetical topic in the world."" " Or something like that?" " Yes." "I might have misquoted him but that's the essence of it." "There's a whole tradition of the depiction of beautiful corpses." " Also in film, by the way." " Whoa!" "Oh, that's even more repellent." "That's... what's his name?" "From Planet of the Apes..." " Dr..." " Dr. Zaius." " Yes, Dr. Zaius." " Who likes to lobotomize people." " Brilliant." " Yes." "No, it's..." "What was it you wanted to say?" " The beautiful corpse?" " That made her horny on the spot." "Well, him too." "She actually looked..." "Never mind." "The mask


mentioned this patina earlier and some parts also have a baroque touch." " How do you mean that?" " Well, exaggerated, grand... baroque." "I'll just continue..." "So the library fits in there pretty good since time has also settled in the books." " Right, it's conserved in them." " Conserved." "Exactly." " The knowledge of the past." " Knowledge of the past." "And we also see now that the building is quite labyrinthian like these hallways the woman just ran along." "It's all very narrow..." "Well, inner worlds, as we said earlier." "What's interesting is that "crime/scenes" according to Binotto's book..." " ...are also the labyrinths inside pyramids." " Does the man pay you for this?" "Nope." "No, I just read it recently - in preparation for thisacted out very drastically." "And if I remember correctly, there's a giallo called What Have They Done to Solange?" "... ...where you can see that saber in her lower abdomen." " Didn't Fuchsberger star in this?" " Yes, I think so." "I think it was marketed in Germany as an Edgar Wallace film." "Well, I wouldn't want to watch this on Blu-ray..." " ...because now the mannequin is nailed on." " But it's beautiful..." "But above all, it doesn't really make much sense, I have to say but it's also, in a way, a mockery of Christian iconography." "Also thanks to the fingernails." "But that's about it." "If there's more to it, I don't know." "We could think about it, but I don't know if we can get


"This is a "gothic giallo"." "I just said that in minute 70." "Yes, I'm a witness." "Yes, now also her character, what was her name again?" " Isn't it Vivian?" " Vivian!" "Vivian it is." "My God, so many names..." "She becomes more distinguishable now since she confesses her love for him." "Right?" " Yes." " But it will have no consequences, right?" "This whole scene here." "I'm asking myself how it'll play out." "It's important that the curse can only be lifted..." " ...by stopping the incest." " Yes, right, right." "And by giving him the prospect for a non-incestuous love and a desire outside of this complex she might bear the power to lift the curse." " Yes." " Period." "Yes." "That's right." "So this is"And despite the approximation via zooming, we still keep our distance." "And this distance remains tangible which leads to the fact that especially in the American film language which more or less became the standard you very rarely see zooms." "It's very interesting that European and particularly the Italian cinema and also Hong Kong cinema, by the way, rely very heavily on zooms and that the influence and the success of genre cinema from Italy and Hong Kong in the late 60s and early 70s caused people like Sam Peckinpah, for example in 1969's The Wild Bunch to employ the zoom again, inspired by the Italo-westerns." "Which is actually very unusual." "It's also present in the works of Stanley Kubrick, in Shining for instance." " That's also a


zoom-film." " That's a beautiful tableau, by the way." "A "tableau" is an artistic arrangement, and..." " Yes, he..." " I just had to laugh because of the bitchslap." " He calmed her down with the bitchslap." " The classic way of calming people down." "Right." " Tableau..." "Yes?" " A tableau with these two corpses." "And that also explains why he nailed her on:" "To make her stay in that shape." "Right, yes..." "Good." " That's also the..." " ...cover motive." "Yes, the cover motive." "Whereas it's not quite clear on the cover motive that they're arranged corpses." "I can't comment on that." "You can only comprehend it now, in the context of the movie why they are lying around there so strangely arranged." "Yes, right, butit somehow reflects its own genre."" "It's irrelevant if he thought that." "It's a fact that we're watching a film that does so, and that's more important." "The director is probably not the only one who made a creative contribution to this." "Especially with a director who's relatively hard to comprehend through his work such as the one at hand, we have to say that it's absolutely possible that many ideas could have been contributed by other participants." "There could've been a lot of reflective elements in the screenplay, in the dialogue which the director simply put into action." "It's not important to say whether the director intended something or not." "We can't say that." "We can only say what the film does." " And the film has


even more detail." "It has something Mephisto-like." "Indeed." "I said "Bava" because shortly before, Bava's Lisa and the Devil came out... where Telly Savalas plays a similarly mysterious figure which could be interpreted as the devil." "Here's of course the certainty that has to be delivered subsequently." "This is something we could find in a story by Edgar Allan Poe:" "The awareness becomes more concrete." "It also happens that the woman here, Lynn, probably falls victim to madness and clue to this awareness literally loses consciousness." "She loses consciousness." "All these things have a lot to do with the Freudian model that we're actually moving inside the subconscious here." " Right." " And that completely physically." "Yes, absolutely." " These are the freshest graves." " Exactly." "That's thethe math library, you will find the library itself at /usr/bin/libm.a and the corresponding header file in your include directory (e.g.:/usr/include/math.h). You have to include the header math.h for the compiler and for the linker specify the library libm.a to resolve the references, which where left by the compiler.
Shared libraries use the extension .so. They are useful if you want to have a small executable file. Here, the references are not resolved by the linker, but when the executable is started, the loader will look for the library dynamically and load them according to the unresolved references into memory.
.dll are dynamically linked libraries for Microsoft Windows and I am not very familiar with them, but I assume, that the steps involved are similar.


\[[@B7-ijms-17-00311],[@B8-ijms-17-00311]\]. HA showed great potential in clinical photodynamic therapy \[[@B9-ijms-17-00311]\]. Although HA has exhibited a variety of pharmacological functions and has been used widely, its anabolic pathway remains unknown.

Perylenequinones, including cercosporin, elsinochrome, phleichrome, cladochrome and hypocrellin, are similar in structure and red in color \[[@B10-ijms-17-00311]\]. The hypocrellin A has been well studied, due to its pharmaceutical potential as anticancer agents through photodynamic tumor therapy. However, cercosporin biosynthesis has been studied long-term and has been used as a model for resistance to ^1^O~2~ and other oxidative stress \[[@B11-ijms-17-00311]\]. Therefore, we can use the working model of cercosporin biosynthetic pathway to study the biosynthesis of HA. In the 1970s, using a substrate-feeding study with acetate and malonate, Okubo *et al.* concluded that cercosporin biosynthesis occurs via a fungal polyketide pathwayrespectively. They were found to have high identity with their corresponding homologous genes through annotation using NR databases. Finally, their sequence information was completely matched with the "*Shiraia* sp. slf14 hypocrellin A biosynthesis gene cluster, complete sequence" (GenBank: KM434884.1, unpublished results) in the NCBI database. Based on the above results, we identified these seven genes as the putative genes of HA biosynthesis.

We proposed a putative HA biosynthetic pathway, shown in [Figure 3](#ijms-17-00311-f003){ref-type="fig"}. It is based on the model of cercosporin biosynthesis, which shares a similar structure, coding genes and is also a perylenequinoid pigment. Similar to cercosporin biosynthesis \[[@B16-ijms-17-00311]\], acetyl-CoA and malonyl-CoA are the precursor and substrate of HA. The first step of the biosynthesis pathway has been predicted to be condensation and decarboxylation of acetyl-CoA (starter) and


a reference genome. A large number of transcripts differentially expressed between the wild strain S4201-W and mutant S4201-D1 have been identified, especially the ones involved in the biosynthesis of HA. In addition, we proposed a putative HA biosynthetic pathway. This study facilitates understanding of the gene expression and functional genomics of *S. bambusicola* and provides a valuable set of public information that can be used to further explore the molecular mechanisms of various metabolic pathways. The transcriptome sequence data will allow for increased HA production using biotechnological applications and metabolic engineering in the near future.

We are sincerely grateful to the anonymous referees whose comments made our results more accessible to the readers. This study was supported by the funds of the National Key Technology Research and Development ProgramNon-biofouling property of well-defined concentrated polymer brushes.
The non-biofouling properties of polymer brushes of poly(2-hydroxyethyl methacrylate) (PHEMA), poly(2-hydroxyethyl acrylate) (PHEA), and poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) were comprehensively studied by varying graft densities (i.e., semi-dilute and concentrated regimes) and the thicknesses at the dry state of 2 and 10 nm. Semi-dilute polymer brushes (SDPBs) were prepared by grafting-to method and concentrated polymer brushes (CPBs) were prepared by surface-initiated atom transfer radical polymerization (SI-ATRP). The adsorptions of proteins with different sizes were investigated on the brushes by quartz crystal microbalance (QCM) from a view point of size-exclusion effect specific to the CPBs. We confirmed that due to the size exclusion effect, the CPBs of all the three much suppressed proteins adsorption and human umbilical vein endothelial cell (HUVEC) adhesion


In particular, purified viable and motile SPZ were recovered from the base of the 80% Percoll fraction ("A SPZ") while abnormal SPZ were recovered from 40% Percoll fraction ("B SPZ"). A and B SPZ pellets were washed once with 10 ml of PBS to remove the Percoll, followed by centrifugation at 500 × *g* for 15 min, and were analyzed in terms of motility and morphology through CASA technology. To do this, we took advantage from Sperm Class Analyzer (SCA) software that records the number of motile/immotile SPZ, with an accurate counting, and it determines SPZ trajectory and velocity. SPZ morphology was, instead, evaluated by staining an aliquot of A and B pellets with SpermBlue, following the manufacturer\'s instructions.

In addition, both SPZ fractions were evaluated under light microscopyOne-Step Evagreen qRT-PCR reaction by using a kit containing qRT-PCR enzyme mix and an Evagreen qPCR Mastermix (Applied Biological Materials Inc.), according to the manufacturer\'s instructions. All reactions were performed by using 50 ng of total RNA on a CFX-96 Real Time PCR System (Biorad). Assays were carried out in triplicates and included a melting curve analysis for which all samples displayed single peaks for each primer pairs. A negative control, without RNA, was also included. RNA expression was evaluated through CFX Manager software (Biorad); normalization was performed using *GAPDH* as housekeeping gene. Normalized fold expression of circRNAs was calculated by applying the 2^−ΔΔ*Ct*^ method.

Statistical Analysis
--------------------

All the data are expressed as the mean ± SEM for triplicate independent measurements. Student\'s t test was used to assess the differences


between experimental groups. Differences with *p* \< 0.05 were considered statistically significant.

Results {#s3}
=======

Overview of circRNA Expression in Human SPZ
-------------------------------------------

A total of 10,726 circRNAs were identified in human SPZ of which the majority (72%) are already present in the most common circRNA database (circBase), instead the 28% was novel based ([Figure 1A](#F1){ref-type="fig"}). According to their structure, circRNA were distinguished in exonic, intronic, intergenic, sense overlapping, and antisense. Exonic circRNAs (84.6%) were the most abundant type of circRNAs in SPZ, while intergenic (0.7%) and antisense (1.8%) were less represented ([Figure 1B](#F1){ref-type="fig"}). According to the location of their host genes, circRNAs were widely distributed across all chromosomes, including mitochondrial (M) chromosome, and on strand + or -- ([Figure 1C](#F1){ref-type="fig"}). However, the highest number of circRNAs was produced on chromosomes 1--3 andpoints ([Figure 3D](#F3){ref-type="fig"}).

![Differential expression of circRNAs between fraction A and B SPZ **(A)** The distribution of up- and down-regulated DE-circRNAs in fraction B compared to fraction A SPZ. **(B)** The distribution of up- and down-regulated DE-circRNAs in the human genome, in according to their host gene location. **(C)** Hierarchical clustering analysis of DE-circRNAs in A SPZ (samples 1A, 2A, 3A) and B SPZ (samples 1B, 2B, 3B); the expression values (Fold change \>1.5, *p* \< 0.05) were represented in different colors, indicating expression levels above and below the median expression level across all samples. **(D)** The volcano plot was constructed using Fold-Change and *p*-values; in detail, the values on X and Y axes are log2 (FC = Fold-Change) and --log10 (*p*-values), respectively. Red points in the volcano plot


represent the DE-circRNAs with statistical significance.](fendo-10-00435-g0003){#F3}

We further performed KEGG pathway analysis for the target genes of SPZ-derived circRNAs, as shown in [Figures 4A,B](#F4){ref-type="fig"}. The Top 20 enriched KEGG signaling pathways were highly associated with steroid biosynthesis, DNA replication, mammalian target of rapamycin (mTOR) signaling pathway, RNA transport and degradation, cell cycle, and oocyte meiosis ([Figures 4A,B](#F4){ref-type="fig"}).

![Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation of host genes **(A)** The Top 20 KEGG signaling pathway annotations in fraction B SPZ up-regulated circRNAs. **(B)** The Top 20 KEGG signaling pathway annotations in fraction B SPZ down-regulated circRNAs.](fendo-10-00435-g0004){#F4}

Functional Clustering of DE-circRNAs
------------------------------------

The analysis of DE-circRNAs led us to hypothesize a particular way of circRNAs to work. CircRNAs (hexagonal symbols)---whose host genes are located on different chromosomes---showed tethering activity toward the same groupsof miRNAs (ovoid symbols). An example of this functional behavior was built in [Figure 5A](#F5){ref-type="fig"} and specifically involved *SMA4* and *GUSP4* circRNAs. Interestingly, this case was found exclusively in circRNAs down-regulated in B compared to A SPZ. On the other hand, more than two circRNAs, whose host genes are located on different chromosomes, were able to tether just the same miRNA. This second case was represented in both up- and down-regulated circRNAs in B compared to A SPZ ([Figure 5B](#F5){ref-type="fig"}).

![Functional clustering of DE-circRNA in B compared to A SPZ **(A)** Two circRNAs whose host genes are located on different chromosomes tether the same group of miRNAs. **(B)** More than two circRNAs show tethering activity toward the same miRNA as target. Networks were built using Cytoscape. Hexagonal and ovoid


need of a more efficient control of some biological pathways through the involvement of more circRNAs. Case (b) more than two DE-circRNAs exert their inhibitory action on the same unique miRNA. This may represent a redundant mechanism to specifically regulate the expression of that miRNA. Furthermore, both case (a) and (b) led us to hypothesize that SPZ-derived circRNAs may work using functional clusters to guarantee a successful fertilization. Surely, this hypothesis needs to be experimentally confirmed in the future.

CircRNA microarray profiling was not randomly validated: we compared our database to Dang et al. circRNA database ([@B17]) and selected circRNAs, surely expressed in SPZ and in some of the human embryonic developmental stages, but not in human oocytes, for experimental validation. Such an analysis perfectly mirrored circRNA microarray results.program.[Footnote 9] The report is
to be submitted 90 days after the DHS's Secretary certifies that all 10
conditions have been successfully met.
Pending Secure Flight's implementation, air carriers will continue to
have primary responsibility for the watch-list-matching function. In
conjunction with our ongoing evaluation of Secure Flight, we testified
in June 2006 that due to delays and uncertainty surrounding Secure
Flight's implementation, some air carriers were enhancing their watch-
list-matching processes. We further identified that these improvements,
though beneficial to the respective air carrier's operations, could
further exacerbate differences that currently exist among the various
air carriers, and could result in varying levels of effectiveness
across air carriers in matching passenger information to the No Fly and
Selectee lists.[Footnote 10]
Due to the importance of identifying passengers who may pose a threat
to commercial aviation, we were asked to review the current


compared none at all. However, TSA
officials noted that the new baseline is not intended to address all
possible types of name variations and the related security
vulnerabilities. Agency officials explained that based on their
analysis of the No Fly and Selectee lists and interviews with
intelligence community officials, the newly established baseline covers
the most critical types of name variations. TSA officials further
stated that this is an interim solution that will strengthen security
while not requiring air carriers to invest in significant modifications
to their watch-list-matching processes, given TSA's expected
implementation of Secure Flight beginning in 2009. These officials
added that when implemented, Secure Flight will be better able to use
passenger names and other identifying information to more accurately
match passengers to the subjects of watch-list records.
TSA has undertaken various efforts to assess domestic air carriers'
compliance with watch-list-matchingrestricted report to DHS and the Department
of Justice for review and comment. DHS had no comments. The Department
of Justice provided technical comments to the restricted version of
this report, which we incorporated where appropriate.
Background:
TSA uses a layered system of defense to secure civil aviation whereby
additional layers provide security when any one security measure may
fail. Watch-list matching is one such layer of defense. Air carriers
began checking passenger names against government-supplied terrorist
watch lists (compiled by the FBI and distributed by the Federal
Aviation Administration) in the early 1990s. After the attacks of
September 11, 2001, and the subsequent establishment of TSA during the
same year, primary responsibility for civil aviation security,
including overseeing the watch-list-matching process, fell to TSA.
[Footnote 23] The Aviation and Transportation Security Act, enacted in
November 2001, requires that a system be used


of field
inspectors testing air carriers' name matching systems in 55 of the
1,109 inspections they conducted in fiscal year 2007 (such tests may
have been administered during the other inspections conducted in fiscal
year 2007 but were not documented).
For the 36 inspections conducted by principal security inspectors at
air carriers' corporate security offices, we found 6 inspection records
that referred to tests of exact-name and similar-name matching
capability (they may have administered such tests during the other
inspections they conducted that year but did not document the tests).
Principal security inspectors did not have an inspection guideline
directing them to assess exact-name and similar-name matching
capability specifically--thus they tested this capability at their own
initiative, and then reported their methods and results in conjunction
with one of the four guidelines presented in table 2. Further, in
response to our inquiry, 6understanding of
what types of comparisons Secure Flight should be capable of
performing.
Concluding Observations:
Shortcomings that have national security implications exist in the
watch-list-matching capability of domestic air carriers, as confirmed
by the results of TSA's recent special emphasis inspection.
Specifically, TSA found differences among air carriers in the
thoroughness and effectiveness of their processes for comparing
passengers' names with those on the No Fly List. A particular concern
involves similar-name comparisons. However, TSA's April 2008 revision
of the No Fly List security directive establishes a baseline name-
matching capability by specifying the types of name variations that air
carriers' processes must be capable of identifying. Effective
implementation of the baseline capability should strengthen watch-list-
matching processes, especially for those air carriers that had been
using less thorough approaches for identifying similar-name matches.
Concurrently, revised internal guidance for TSA's inspectors can help
ensure that compliance


decisions are based upon testing and that these
tests are carried out regularly, using the standards specified within
the security directives as evaluation criteria. Also, if properly
documented in inspection reports, the results of these tests could give
TSA management better information on the quality of watch-list matching
being conducted by air carriers, thereby improving TSA's monitoring of
the overall security posture of the aviation sector. At the time of our
review, TSA's process for revising its guidance was in the initial
stages; thus it is too early to determine the extent to which updated
guidance for principal security inspectors and transportation security
inspectors would strengthen oversight of air carriers' compliance with
the security directive requirements. Given continued delays in the
implementation of the Secure Flight program, TSA's oversight of air
carriers' compliance with watch-list-matching requirements remains an
important responsibility. TSA officialscarriers during calendar year 2005-
-the most recent year for which data were available when making our
selections in 2006.[Footnote 64] To the extent possible, we identified
the number of domestic enplanements for those air carriers required to
perform watch-list matching in 2005, identified within the previously
cited TSA list. According to our calculations, the 14 air carriers in
our study accounted for approximately 70 percent of all passengers who
boarded domestic air carriers' flights during calendar year 2005, and
thus, our selection allowed us to understand how watch-list matching
was performed for the majority of passengers flying domestically in
2005. Although the 14 domestic air carriers we selected represent a
range in size of air carrier operations and transported a majority of
passengers that boarded domestic flights in calendar year 2005, the
results of our interviews are not generalizable to


all domestic air
carriers.
To help ensure consistency in conducting our interviews with air
carriers, we developed a data collection instrument with questions
focusing on air carriers' implementation of certain requirements of the
No Fly and Selectee list security directives. We conducted four of
these interviews in person at the air carriers' headquarters and the
rest via telephone. In addition, to clarify our understanding of air
carriers' processes, we conducted follow-up phone interviews with four
selected air carriers and received written answers to our follow-up
questions from an additional four selected air carriers. The air
carrier officials who answered our questions generally held positions
in corporate security and regulatory affairs; however, half of the air
carriers also had information technology systems specialists
participate to answer technical questions related to automated name-
matching systems. We did not audit or independently verify each air
carrier's implementationand Selectee lists. These lists contain
applicable records from the Terrorist Screening Center's consolidated
database of known or appropriately suspected terrorists. See GAO,
Terrorist Watch List Screening: Recommendations to Promote a
Comprehensive and Coordinated Approach to Terrorist-Related Screening,
[hyperlink, http://www.gao.gov/cgi-bin/getrpt?GAO-08-253T] (Washington,
D.C.: Nov. 8, 2007).
[2] The number of domestic air carriers has varied over time, for
example, from 95 in 2005 to about 70 in 2007. For the purposes of this
report, domestic air carriers are those with operations based in the
United States that maintain full security programs in accordance with
49 C.F.R. part 1544. Foreign air carriers--air carriers with operations
based outside the United States--must also comply with U.S. security
regulations, including applicable requirements for watch-list matching,
when operating flights to or from the United States in accordance with
49 C.F.R. part 1546. Both domestic and foreign air carriers may


conduct
international flights to and from the United States; however, these
operations are outside the scope of this report.
[3] See GAO, Terrorist Watch List Screening: Opportunities Exist to
Enhance Management Oversight, Reduce Vulnerabilities in Agency
Screening Processes, and Expand Use of the List, [hyperlink,
http://www.gao.gov/cgi-bin/getrpt?GAO-08-110] (Washington, D.C.: Oct.
11, 2007). We reported that TSA's Office of Intelligence documented
various incidents (for the period January 1, 2005, through June 3,
2007) in which air carriers--both domestic and foreign--allowed
individuals on the No Fly List to board international flights traveling
to or from the United States. Several of these incidents involved
flights of domestic air carriers. We asked TSA's Office of Intelligence
to identify any additional incidents in which a No Fly listed
individual flew on a domestic air carrier for the period June 4, 2007,
through December 31, 2007, and TSA identified noinspectors.
[21] According to TSA data, these 1,145 watch-list-related inspections
(36 plus 1,109) covered 60 domestic air carriers, and most of the air
carriers were inspected multiple times.
[22] TSA reported that the January 2008 special emphasis inspection
covered 52 domestic air carriers and 31 foreign air carriers.
[23] In accordance with 49 U.S.C. § 114(h), TSA adopted policies and
procedures for ensuring that air carriers use information from
government agencies to identify individuals on passenger lists who may
be a threat to civil aviation or national security and, if such an
individual is identified, notify appropriate law enforcement agencies,
prevent the individual from boarding an aircraft, or take other
appropriate action with respect to that individual.
[24] Pub. L. No. 107-71, § 136, 115 Stat. 597, 637 (2001) (codified at
49 U.S.C. § 44903(j)(2)(A)) (requiring use of the Computer Assisted
Passenger Prescreening


in Key Aviation Security Programs, but More Work
Remains, [hyperlink, http://www.gao.gov/cgi-bin/getrpt?GAO-08-465T]
(Washington, D.C.: Feb. 28, 2008).
[62] One objective of the Federal Identity Match Search Engine
Performance Standards Working Group is to provide guidance to improve
the effectiveness of the automated search engines that federal agencies
use for conducting identity matching. The group began meeting in
December 2005. It included representatives from the departments of
Homeland Security, State, and Defense; FBI; the intelligence community;
and the National Institute of Standards and Technology.
[63] Specifically, we reviewed the Secure Flight notice of proposed
rulemaking (72 Fed. Reg. 48,356 (Aug. 23, 2007)) and final concept of
operations for Secure Flight (dated Mar. 9, 2007). We also reviewed our
most recent reports and testimonies on the program.
[64] Specifically, the data reflect the number of domestic passengers
who boarded (enplaned) at a flight's point of originnames are compared to the most current No Fly and Selectee
Lists in accordance with the procedures outlined in Security Directive
1544-01-20 series (No Fly) and Security Directive 1544-01-21 series
(Selectee)." Because these two guidelines were used for the same
purpose but at different times during fiscal year 2007, we combined the
data associated with each one and treated them as one inspection
guideline for the purposes of this report.
[70] Our calculations were based only on the 12 inspection guidelines
relevant to our review.
[71] To identify these requirements, we reviewed the No Fly List
Procedures and Selectee List Procedures security directives (series SD
1544-01-20 and SD 1544-01-21, respectively). This report discusses only
the requirements within the two security directives pertaining to
domestic flights (defined as flights occurring between points within
the United States and its territories), though these same requirements
generally


using the group-sequential method, but require that a single treatment continues along with a control beyond the first stage [@StallardTodd03] or that the number of treatments at each stage is specified in advance [@StallardFriede08]. The second group of methods is based on the combination test approach of @bk94. Such methods are more flexible (see, for example, @BauerKieser99, @Posch05, and @Bretz06), but may be less powerful in some settings [@FriedeStallard08]. Magirr et al. (2012) proposed a group-sequential method that does allow completely flexible treatment selection, though this may be at the cost of conservatism and an associated loss in power. @Koenig08 showed how the conditional error principle of @MuellerSchaefer01 may be used to extend the Dunnett test [@Dunnett55] to a two-stage design with flexible treatment selection. This has beenthe subgroup and the second element is the effect size in the full population, . So here we are assuming an effect size of 0.3 in the subgroup and 0.1 in the full population; the effect size in the control group is set by default to be zero. The default setting is for normal outcomes for both early and final outcomes, , and the effects are interpreted given these options. The allowed options for outcome types are normal (), time-to-event () and binary (), and all combinations of these are allowed for early and final outcome measures. Generally, it is assumed that higher means () and lower event rates ( or ) are better. A detailed description of these options is left for the following section describing function


be tested at the trial endpoint, whereas if only the test regarding the population with the largest test statistic at interim is taken into stage 2. Intermediate values for between these extremes provide more flexible selection options. The weight for the CT approaches, if unset, is given by $n_{stage 1}/(n_{stage 1}+n_{stage 2})$ and the test level is set by default to 0.025 ().

  $Argument$   $Description$                                                            \ldots, S^{(2)}_{1J}, S^{(2)}_{2J})^\prime$$ is normally distributed with mean $$\left (
\begin{array}{c}
\theta^{(1)} \otimes I^{(1)} \\
\theta^{(2)} \otimes I^{(2)}
\end{array}
\right )$$ and variance $$\left (
\begin{array}{cc}
\Sigma^{(GS)}(I^{(1)}) & \rho \Sigma^{(GS)}(I^{(12)}) \\
\rho \Sigma^{(GS)}(I^{(12)}) & \Sigma^{(GS)}(I^{(2)})
\end{array}
\right )
\otimes \Sigma^{(GS)}\left ( \begin{array}{c} \tau \\ 1 \end{array} \right )$$ where $I^{(i)} = (I^{(i)}_1, \ldots, I^{(i)}_J)^\prime$, $I^{12} = (I^{(12)}_1, \ldots, I^{(12)}_J)^\prime$ with $I^{(12)}_j = \sqrt{I^{(1)}_j I^{(2)}_j}$, $\theta^{(i)} = (\theta^{(i)}_1, \theta^{(i)}_2)$ and $\Sigma^{(GS)}(I)$ and $\Sigma^{(CS)}_K(r)$ are as defined above.

If more than two subgroups are considered, or if these are nested in some other way than the second being a subset of the first, the last matrix can be modified accordingly to reflect this.

[99]{}

Barnes, P.J., Pocock, S.J., Magnussen, H., Iqbal, A., Kramer, B., Higgins, M., and Lawrence, D. (2011). Integrating indacaterol dose selection in a clinical study in COPD using an adaptive


after subpopulation selection in adaptive seamless trials. *Statistics in Medicine* **34**, 2581–2601.

Kimani, P.K., Todd, S., and Stallard, N. (2018). Point estimation following two-stage adaptive threshold enrichment clinical trials. *Statistics in Medicine* **34**, 2581–2601.

Koenig, F., Brannath, W., Bretz, F. and Posch, M. (2008). Adaptive Dunnett tests for treatment selection. *Statistics in Medicine* **27**, 1612–1625.

Kunz, C.U., Friede, T., Parsons, N., Todd, S., and Stallard, N. (2014). Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data. *Pharmaceutical Statistics* **13**, 238–246.

Kunz, C.U., Friede, T., Parsons, N., Todd, S., and Stallard, N. (2015). A comparison of methods for treatment selection in seamless phase II /III clinical trials incorporating information on short-term endpoints. *Journal of Biopharmaceutical Statistics* **25**, 170–189.

Lan, K.K.G. and DeMets, D.L. (1983). Discrete sequential boundaries for clinical trials. *Biometrika* **70**, 659–663.

Lehmacher, W. and Wassmer, G. (1999). Adaptive sample size calculation inthe modified Wilcoxon statistic. *Journal of the American Statistical Association* **77**, 862–868.

Spiessens, B. and Debois, M. (2010). Adjusted significance levels for subgroup analysis in clinical trials. *Contemporary Clinical Trials* **31**:647–656.

Stallard N. (2010). A confirmatory seamless phase II/III clinical trial design incorporating short-term endpoint information. *Statistics in Medicine* **29**, 959–-971.

Stallard, N. and Friede, T.(2008). A group-sequential design for clinical trials with treatment selection. *Statistics in Medicine* **27**, 6209–6227.

Stallard, N. and Kimani, P.K. (2018). Uniformly minimum variance conditionally unbiased estimation in multi-arm multi-stage clinical trials. *Biometrika* **105**, 495–501.

Stallard, N. and Todd, S.(2003). Sequential designs for phase III clinical trials incoporating treatment selection. *Statistics in Medicine* **22**, 689–703.

Stallard, N., Homburg, T., Parsons, N., and Friede, T. (2014). Adaptive designs for confirmatory clinical trials with subgroup selection. *Journal of Biopharmaceutical Statistics* **24**, 168–187.

Stallard, N., Kunz, C.U., Todd, S., Parsons, N., and Friede, T. (2015).


for the prediction of protein targets for small molecule ligands \[[@CR12], [@CR18]--[@CR22]\]. The former methods generally describe approaches that exploit the structural information of the protein, combined with scoring functions, in an attempt to predict ligand--target pairs \[[@CR23]--[@CR25]\]. Ligand-based methods investigate an identified structure--activity relationship (SAR) space, using similarity searching on large numbers of annotated protein--ligand pairs obtained from chemogenomic databases \[[@CR26]--[@CR29]\]. Such predictive models are founded upon the principle of chemical similarity, relying on the relevant similarities of compound features from targets which are likely to be responsible for binding activity \[[@CR30], [@CR31]\]. The focus of this work is concerned with improving current ligand-based methods for target prediction.

Similarity searching for ligand-based target prediction is considered the simplest form of in silico target prediction and has long beenan external data set extracted from WOMBAT. It is important to recognize that the bioactivity information included for the compounds-protein associations contained in WOMBAT do not contain experimentally confirmed inactive compounds, and that molecules without an annotation for a target are simply considered as inactive for that protein. Although this assumption may be correct in many cases, there are likely to be certain instances when a compound may actually be active. If these compounds were correctly annotated as active by the target prediction tool (a '*false* false positive', and hence a 'true positive'), this prediction would be penalised as a false positive due to the assumptions applied by the test data.

Figure [4](#Fig4){ref-type="fig"} and Table [1](#Tab1){ref-type="table"} illustrate the performance of the models upon application of the different thresholds to the predictions


0.3 could be applied if a distance-based approach toward the AD is employed for this target prediction methodology. If a query molecule were above this threshold, this would indicate confidence in the reliability of the probabilities generated for the models. In comparison, a Tc value below this threshold would indicate that the probabilities produced by the models are not consistently dependable. Notably, the models are able to retain some good performance in conditions of low Tc values between 0.2 and 0.1, which suggest that all probabilities for these classes should not be discarded. Predictions for targets with a query-to-train distance below 0.03 should be considered unreliable, as these models do not encapsulate sufficient chemical space for a given query compound.Fig. 6AD analysis of the True Positives from the WOMBATattempt to create a useful repository for mining in the future \[[@CR59], [@CR60]\].

Sphere exclusion for putative inactive sampling {#Sec13}
-----------------------------------------------

The data extracted from PubChem contains a very large variance in the number of inactives extracted for each of the targets, with some encompassing little or no experimental inactives. Mixing experimental inactives with putative inactives would alleviate this issue, at the cost of producing models that are no longer trained solely on confirmed evidence of inactivity. Although this caveat may remove the benefit of predicting on truly inactive data from the current state of the models, refraining from any additional sampling would result in overtly imbalanced training data for 480 targets, which would otherwise require removal.

A sphere exclusion (SE) algorithm was utilized to randomly sample 'presumed inactive' compounds from a


numbers of inactive compounds, undersampling was performed through the randomised removal of instances from the inactive class to accomplish the desired ratio. The complete data set of 206,559,765 ligand-target pairs from both the active and inactive classes is available for use as a benchmark data set (see Additional file [1](#MOESM1){ref-type="media"}).

Chemical descriptors {#Sec14}
--------------------

RDKit \[[@CR52]\] was used to generate hashed ECFP_4 circular Morgan fingerprints \[[@CR63]\] with a 2048 bit length. ECFP fingerprints were selected as they have previously been shown to be successful when attempting to capture relevant molecular information for in silico bioactivity prediction \[[@CR39], [@CR64]\].

Conclusions {#Sec15}
===========

We have implemented a method for the extraction of inactive compounds from the PubChem repository. The application of a sphere exclusion algorithm enabled the oversampling of additional inactive compounds for targets with insufficientthe ability of the algorithm to interpret the binary bit string features used to describe compound inputs. In comparison to other methods, this algorithm is also capable of maintaining its predictive power for highly imbalanced datasets, which is particularly beneficial when attempting to utilise large numbers of negative instances in training data \[[@CR65], [@CR66]\]. For example, it has been shown that enlarged negative training set sizes hinder the recall performance of the SMO, Random Forest, Ibk and J48 algorithms \[[@CR67]\]. The preferable ratio of active to inactive compounds for these methods was found to be only around 1:9, a significant decrease from the 1:100 ratio envisaged for this study. Such algorithms would therefore require large scale undersampling of inactives data points to obtain acceptable performance, thus sacrificing the


ratio function (*R*~*Score*~) is defined as:$$\documentclass[12pt]{minimal}
                \usepackage{amsmath}
                \usepackage{wasysym}
                \usepackage{amsfonts}
                \usepackage{amssymb}
                \usepackage{amsbsy}
                \usepackage{mathrsfs}
                \usepackage{upgreek}
       gene for X‐linked cognitive disability. Homozygous ZC4H2 mutant results in abnormal swimming capacity, pectoral fin flexion, and eye position in zebrafish (May et al., [2015](#mgg31100-bib-0015){ref-type="ref"}). These findings are consistent with contractures and exotropia observed in patients with ZC4H2 mutations.

In this study, we identified a novel mutation in *ZC4H2* gene in a female patient suffering from Wieacker‐Wolff syndrome. We investigated the XCI pattern of this patient and subcellular location of the truncated ZC4H2 protein. Our study provided novel insights into ZC4H2\'s role in the pathogenesis of Wieacker‐Wolff syndrome.

2. MATERIALS AND METHODS {#mgg31100-sec-0006}
========================

2.1. Ethical approval {#mgg31100-sec-0007}
---------------------

All samples were collected after the couple had given their written informed consent, and the study was approved by the research ethical committee of the Children\'s Hospital of Chongqing Medical University.

2.2. Whole‐exome sequencing {#mgg31100-sec-0008}
---------------------------

Coding exons


nonrandom XCI might be responsible for this phenomenon (Hirata et al., [2013](#mgg31100-bib-0010){ref-type="ref"}). However, it was found that even in female patients with the same mutation and similar phenotypes, their XCI was varied (May et al., [2015](#mgg31100-bib-0015){ref-type="ref"}). A female patient with a severe phenotype caused by a small heterozygous deletion of the *ZC4H2* gene at Xq11.2 and a female with a mild phenotype caused by a p.Q50X nonsense mutation showed randomized X inactivation. These results indicate that there is no strong correlation between X inactivation and disease phenotype. The proband patient in our current study carrying a nonsense mutation (p.R67X) for a truncated protein with a more serious phenotype showed an XCI ratio of 22:78, which also suggests that X inactivation could not account for the phenotypic discrepancy inSuperman renounces his U.S. citizenship in Action Comics‘ record-breaking 900th issue. But that’s not all the benevolent alien refugee does in the sprawling special issue, which hits stores Wednesday.
The Man of Steel throws down in... Read Post


1,394 673
6 1,090 647 694 211
7 39 162 85 16
Totals 7,671 9,146 8,236 3,704
Age Range of Volunteers
Under 18
Over 61
36–61 18–35
Paul Blevins at Bon Secor NWR in Alabama provides refuge information to visitors.
7
Volunteer Program Values
The value of volunteers is
astounding! We realized a 650%
return on our investment in Fiscal
Year 1999. Volunteers contributed
1,277,207 hours valued at more
than $13 million. Service staff
contributed 37,856 hours ensuring
that volunteers had supervision,
proper training, housing, adequate
supplies and equipment and, of
course, fun!
Volunteer Hours/Value
Region Volunteers Hours Value*
1 10,006 320,251 $3,095,050
2 2,981 177,252 $1,815,060
3 4,272 173,511 $1,776,753
4 4,214 240,672 $2,464,481
5 4,340 207,304 $2,122,834
6 2,642 123,266 $1,262,244
7 302** 52,947 $ 542,177
Totals 28,757 1,277,207 $13,078,599
*Value is derived using the U.S. Office of Personnel Management 1999 General Pay
Schedule of a GS 5-1.
**Historically, Alaska (Region 7) has the fewest numbers of volunteers. However, these
volunteerswork long hours to accomplish their goals within the short, demanding
summer season.
Volunteer Program Operating Costs
Operations Staff
Region Costs Hours
1 $353,500 2,349
2 $254,322 11,542
3 $141,687 1,671
4 $242,770 2,349
5 $661,596 15,183
6 $210,908 4,412
7 $185,800 350
Totals $2,050,583 37,856
Number of Volunteers
By Region
Volunteer Program Operating Costs
By Region
1
2
4
5
6
7
3
1
2
4
5
6
7
3
8
Student Conservation Association
The U.S. Fish & Wildlife Service
and the Student Conservation
Association (SCA) have enjoyed 18
years of partnership of volunteers.
SCA is an important source of
qualified, full-time volunteers. In
1999, SCA recruited, placed, and
supported more than 100 Service
volunteers nationwide. Through
SCA, we obtain qualified students
and help them develop conservation
and leadership skills. SCA provided
volunteers and interns to us through
four programs: the Resource
Assistant Program, the
Conservation Associates Program,
the Conservation Work Crew
Program, and the Conservation
Career Development Program.
Resource Assistant Program
SCA Resource Assistants are
college-age volunteers placed in
positions similar to that of seasonal
employees. Many of these volunteers
serve as interns


a mix of both!
No matter what the task, volunteers
are there to make it happen!
What Is the
Volunteer Program?
Volunteer Diane Bruell gets a personal
lesson in raptor handling at Rocky
Mountain Arsenal NWR in Colorado.
Diane has donated more than 5,000 hours!
Volunteer Linda Conlin is rinsing
Lahontan Cutthroat Trout eggs in the
spawning shed located at Pyramid
Lake, Nevada.
6
Our volunteers are high school
students planting trees, Girl Scouts
working on merit badges, college
students surveying duck nests,
outdoor enthusiasts maintaining
trails, and retirees staffing visitor
centers, just to name a few.
Volunteers come from all walks of
life and bring all levels of expertise.
Each one is unique and offers their
own special skills to our Nation’s
wild places.
Volunteers include talented and
dedicated people:
Like Paul Blevins at Bon Secor
National Wildlife Refuge in
Alabama who has volunteered at the
refuge for the last 20 years! Every
day, Mr. Blevins, walks the refuge’s
JeffConservation Work Crew
Program, and the Conservation
Career Development Program.
Resource Assistant Program
SCA Resource Assistants are
college-age volunteers placed in
positions similar to that of seasonal
employees. Many of these volunteers
serve as interns and receive college
credit for their efforts. The
Resource Assistant Program is the
most popular among college-age
students. Seventy-eight of SCA’s 957
volunteers worked for the U.S. Fish
& Wildlife Service. This program
allowed students to gain highly
valued hands-on field experience
while working under the supervision
of professionals in their field of
study. This year 42 stations hosted
SCA interns and volunteers.
Conservation Associates Program
Established in 1996, the
Conservation Associates Program
provides longer term volunteer work
and consists primarily of students
over 21 years of age. Of the 171
Conservation Associates placed,
9 worked on Service lands.
Conservation Work Crew Program
Conservation Work Crews consist of
up to eight students per crew. The
crews accomplished a tremendous
amount of trail work at Great Bay
NWR,


allows the
refuge to bring on three Interns
throughout the year and provide
them with a small stipend. The
company has also been active in the
Volunteer Program by allowing their
employees to volunteer at the refuge
on company time.
Leavenworth NFH (WA) partnered
with a variety of local organizations
to carry out the mission of the
hatchery including Trout Unlimited,
Chelan County Worker Inmate
Crew, Private Industry Council-
Wenatchee Washington Office, and
Entiat High School. These groups
provided essential support to the
hatchery for operations,
maintenance, education, and
outreach.
Employees from the Morrison
Knudsen Environmental
Corporation were recruited to
conduct environmental education
programs at the Rocky Mountain
Arsenal NWR (CO) during their
work hours. Shell Oil Company
funded half of the hours with the
other half being contributed to the
Volunteer Program.
Hamden Slough NWR (ND)
partnered with North Dakota State
University, National Soils
Laboratory, and the National Hydric
Soils Technical Committee to bring
scientists from around the Nation to
a soil seminar         *}
{foreach from=$dirWalk item=dir key=key}
{include file="vc2k8_fileRecurse.tpl" dirWalk=$dir dirName=$key dirPath="$dirPath$dirName/" depth=$depth+1}
{/foreach}
{if $depth > 2}
{*                                   *}
{*      Generate dir suffix          *}
{*                                   *}
{capture assign="dirSuffix"}
</Filter>{/capture}
{$dirSuffix|indent:$depth:"\t"}
{/if}
{else}
{*


Non-penetrating subclavian artery trauma: management by selective transluminally placed stent device.
Non-penetrating injury to the subclavian artery has not often been reported. The limited experience of surgeons with this type of trauma and the difficult vascular control required for its management make it a surgical challenge. We report on two cases, one after blunt trauma and the other with a subclavian artery aneurysm following anterior dislocation of the shoulder. Percutaneous stent implantation in the subclavian artery was successfully performed with, in the second case, coil embolization of the aneurysm. Follow-up Doppler sonography and angiogram demonstrated patency and luminal integrity of the involved artery. This less invasive procedure may be a significant advance and a new approach in the conservative management of traumatic subclavian injury for selected cases.and would love to hook up for dirty sex sessions. What they DON'T want is relationships (at least not at this point in their lives). They just want to meet like-minded free-spirits who are capable of hooking-up without getting attached or clingy. This is all about the shagging, and nothing more. So you can find anal sex and oral sex very easily and also group sex sessions as they are often held in Linton, there are sex parties and threesomes all of the time with locals looking for new meat for their awesome group sex sessions so just get in touch with them. I push myself against him, moving my hips as best I can under him trying to penetrate myself but he presses me down letting his


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directly to soiled fruits and vegetables, followed by rinsing in tap water. The clarity of the liquids connotes cleanliness to the user and is thus highly desirable. Low sudsing is an important attribute so that removal of the solution by rinsing is achieved quickly and easily. It would also be of advantage if such compositions could be provided in the form of concentrates, which could be diluted by the consumer before use and/or applied to the fruits and vegetables as a direct spray-on.
Unfortunately, many toxicologically-acceptable cleaning ingredients do not meet the aforesaid requirements for clear, low-sudsing, dilutable liquid products. Many detersive surfactants form cloudy or even opaque suspensions, even in soft water. Of course, many surfactants are specifically designed to be high sudsing. Still others form relatively intractabledirections, the
nature of which will become apparent in the course of this report, the
presence and co-operation of these French troops would have been of the
greatest value.

The Enemy's Defences

2. The German defences on
this front had been greatly improved and extended since the opening of our
offensive in April, and comprised three main systems of resistance.

The first of these three
trench systems, constituting part of the Hindenburg Line proper, ran in a
general north-westerly direction for a distance of six miles from the Canal
de l'Escaut at Banteux to Havrincourt. There it turned abruptly north
along the line of the Canal du Nord for a distance of four miles to
Moeuvres, thus forming a pronounced salient in the German front.

In advance of the
Hindenburg Line the enemy had constructed a series of strong forward
positions, including La Vacquerie


northwards along the Hindenburg Line and its
forward defences, maintaining touch with the West Riding troops, and carried
the whole of the German trench systems west of the Canal du Nord as far
north as the Bapaume-Cambrai Road.

At the end of the first day
of the attack, therefore, three German systems of defence had been broken
through to a depth of some four and a half miles on a wide front, and over
5,000 prisoners had already been brought in. But for the wrecking of
the bridge at Masnieres and the check at Flesquieres, still greater results
might have been attained.

Throughout these operations
the value of the services rendered by the tanks was very great, and the
utmost gallantry, enterprise and resolution were displayed by both officers
and crews. In combination with the other arms they helped to make
possibletheir pieces.

East of Villers Guislain
the troops holding our forward positions on the high ground were still
offering a strenuous resistance to the enemy's attack on their front, at a
time when large forces of German infantry had already advanced up the valley
between them and Villers Guislain.

South of this village a
single strong point known as Limerick Post, garrisoned by troops of the
1/5th Battalion (King's Own), Royal Lancaster Regiment, and the 1/10th
Battalion, Liverpool Regiment (both of the 55th Division), held out with
great gallantry throughout the day, though heavily attacked.

The progress made by the
enemy, however, across the northern end of the Bonavis Ridge and up the deep
gully between Villers Guislain and Gonnelieu, known as 22 Ravine, turned our
positions on the ridge as well as in both villages. Taken in flank and
rear, the defences


as' eleven waves of German
infantry advanced successively to the assault. On the whole of this
front a resolute endeavour was made to break down by sheer weight of numbers
the defence of the London Territorials and other English battalions holding
the sector.

In this fighting the 47th
(London) Division (T.) (Major-General Sir G. F. Gorringe), the 2nd Division
(Major-General C. E. Pereira) and the 56th (London) Division (T.) greatly
distinguished themselves, and there were accomplished many deeds of great
heroism.

Under the fury of the
enemy's bombardment a company of the 17th Battalion, Royal Fusiliers, were
in the course of being withdrawn from an exposed position in a sap-head in
advance of our line between Bourlon Wood and Moeuvres when the German attack
burst upon them.

The officer in command sent
three of his platoons back, and with a rearguard composed of theremainder
of his company held off the enemy's infantry until the main position had
been organised. Having faithfully accomplished their task, this
rearguard died fighting to the end with their faces to the enemy.

Somewhat later in the
morning an attack in force between the Canal du Nord and Moeuvres broke into
our foremost positions and isolated a company of the 13th Battalion, Essex
Regiment, in a trench just west of the canal. After maintaining a
splendid and successful resistance throughout the day, whereby the pressure
upon our main line was greatly relieved, at 4.0 p.m. this company held a
council of war, at which the two remaining company officers, the company
sergeant-major, and the platoon sergeants were present, and unanimously
determined to fight to the last and have "no surrender".

Two runners who were sent
to notify this decision to Battalion


command and
inter-communication in the whole area between the Canal de l'Escaut, the
River Sensee and the Canal du Nord, as well as to the east and north-east of
Cambrai.

My intentions as regards
subsequent exploitation were to push westward and north-westward, taking the
Hindenburg Line in reverse from Moeuvres to the River Scarpe, and capturing
all the enemy's defences and probably most of his garrisons lying west of a
line from Cambrai northwards to the Sensee, and south of that river and the
Scarpe.

Time would have been
required to enable us to develop and complete the operation; but the
prospects of gaining the necessary time, by the use of cavalry in the manner
outlined above, were in my opinion good enough to justify the attempt to
execute the plan.

I am of opinion that on the
20th and 21st November we wentlack of training, or exhaustion from
previous fighting.

Captured maps and orders
have made it clear that the enemy aimed at far more considerable results
than were actually achieved by him. Three convergent attacks were to
be made on the salient formed by our advance; two of them delivered
approximately simultaneously about Gonnelieu and Masnieres, followed later
by a still more powerful attack on the Bourlon front.

The objectives of these
attacks extended to the high ground at Beaucamp and Trescault, and the
enemy's hope was to capture and destroy the whole of the British forces in
the Cambrai salient.

This bold and ambitious
plan was foiled on the greater part of our front by the splendid defence of
the British divisions engaged; and, though the defence broke down for a time
in one area, the recovery made by the weak forces still


left and those
within immediate reach is worthy of the highest praise. Numberless
instances of great gallantry, promptitude and skill were shown, some few of
which have been recounted.

I desire to acknowledge the
skill and resource displayed by General Byng throughout the Cambrai
operations, and to express my appreciation of the manner in which they were
conducted by him, as well as by his Staff and the subordinate commanders.

In conclusion, I would
point out that the sudden breaking through by our troops of an immense
system of defence has had a most inspiring moral effect on the Armies I
command, and must have a correspondingly depressing influence upon the
enemy.

The great value of the
tanks in the offensive has been conclusively proved. In view of this
experience, the enemy may well hesitate to deplete any portion of his front,
as hecascades that are essential during cancer progression. Being initially discovered in cancers, their biological functions have mostly been studied in the oncology field \[[@CR3], [@CR4]\]. Overexpression of AXL and to a lesser extent of MER has been described in multiple malignancies from epithelial and hematological origins and is often associated with poor prognosis \[[@CR1]••, [@CR5]--[@CR9]\]. Several studies highlight the role of AXL activation in tumor progression and metastasis development. In most settings, AXL/MER expression is induced together with the appearance of drug resistance to conventional or targeted therapies (Table [1](#Tab1){ref-type="table"}). Moreover, AXL expression is associated with epithelial to mesenchymal transition (EMT), a frequent feature of metastatic tumors often correlated to drug resistance. Both tumor and stromal cells from the microenvironment can produce GAS6, fostering a crosstalk between the


Moreover, a correlation between HIF-1 and AXL expression has been shown in metastatic prostate cancer, where hypoxia stabilized the AXL protein \[[@CR22]\]. Lastly, one study demonstrates the role of the myeloid zinc finger 1 protein (MZF-1) in colorectal and cervical cancer cell lines \[[@CR23]\].

Some studies have highlighted the regulation of *AXL* transcription in cancer through feedback loops induced by other RTKs. In NSCLC and head and neck squamous cell carcinoma (HNSCC) for example, EGFR signaling and downstream MEK/ERK activation induces expression of *AXL* mRNA via the JUN transcription factor \[[@CR24]\]. Similar findings have been described in bladder cancer where *AXL* mRNA is induced after MET activation and downstream MEK/ERK signaling \[[@CR25]\].

Alternative Transcriptional Control {#Sec4}
-----------------------------------

Two microRNAs (miRNAs) have been described as repressors of AXL expression: miR-34a and miR-199a/b. Thesethe tumor and/or stromal cells. To cite a few examples, autocrine activation and production of GAS6 by tumor cells have been described for melanoma, GIST, and breast cancers \[[@CR39]--[@CR42]\]. Secretion of GAS6 from the tumor microenvironment has been shown in colon, breast, and prostate cancers as well as in AML. In glioblastoma, breast cancer, and AML, both autocrine and paracrine secretion of ligands have been detected \[[@CR6], [@CR43]\]. The production of GAS6 by stromal cells can create a specific niche in which AXL signaling cascades are activated and favor metastasis development \[[@CR44]••\]. Apart from ligand binding, little is known as to the regulation of AXL/MER activation. A soluble form of AXL/MER has been described to negatively regulate AXL/MER signaling by acting as an antagonist to GAS6 \[[@CR45], [@CR46]\].