trademark.

Not sure how else Apple could proceed here.

~~~
CogitoCogito
> Not sure how else Apple could proceed here.

Apple could simply have looked at it and said "this mark would never be
confused with ours" and then been done with it.

------
pg_1234
The nuclear option that could be implemented by a grassroots movement is an
organized campaign to use Apple's trademarks in such a way that they become
genericised.

see:
[https://en.wikipedia.org/wiki/Generic_trademark](https://en.wikipedia.org/wiki/Generic_trademark)

Even the smallest amount of headway in this direction represents such a threat
to Apple that despite it's might, it would have to back down.

~~~
schwartzworld
What is that? like we all agree to just start calling all computers
"MacBooks"?

~~~
dmurray
At one point people were calling all tablets iPads - that's probably the one
that had the biggest risk of genericization.

~~~
hoppla
Airport security do this - say iPad when they mean tablets. They also get
upsetwhether we could use "wxWindows" as the name or
not.

As for "modest financial compensation", it was really modest and was meant to
compensate for registrar fees/changing hosting/stuff like that. It was a
couple of thousands at most, I think, nowhere near enough to sustain anything
for any period of time.

------
LatteLazy
In the US, everyone pays for their own lawyer, even when they lose. So it
makes sense for companies like apple with deep pockets to sue others, they win
by forcing their opponent to pay huge legal bills indefinately.

But that's not true (I believe) in Canada. So what's the deal here? Do Apple
actually think pears are apples and they can win the case?

~~~
gridlockd
It's more about defending your trademark. In principle, Apple doesn't care
about some random company using a pear, but if they don't defend it


see anyone Retweeting AAPL SWEs voicing their
support of Prepear (or Epic Games...). I know their social-media policy stems
from their culture of secrecy, but it also has the effect of making it seem
like everyone toes the company-line.

~~~
coeneedell
This is partially what I'm concerned about. From the basic facts that I've
seen about this case I believe that Apple is in the wrong. That being said,
seeing prepear resort to dehumanizing tactics in trying to rally the public
beside them is disconcerting. I think there's an "every foot counts" mentality
in activism these days that's not just destructive to the state of discourse,
but is actually counterproductive as well.

------
alashley
I have a question that's related to something like this, I haven't been able
to find a definitive answer through Google.

So let's say I want to create an appThe Nordic ski family is going to Ruka (FIN) this weekend where the FIS Nordic World Cup Opening is set to take place from 24th-26th November 2017.

The event is the traditional curtain-raiser for the Nordic season, with the first World Cup competitions presented by Viessmann in Cross-Country Skiing and Nordic Combined, while men’s Ski Jumping will make its second stop following its opening last weekend in Wisla (POL).

Organisers have confirmed snow conditions in Ruka are ideal ahead of the events.

In total, eleven World Cup competitions, six in Cross-Country, two in Ski Jumping and three in Nordic Combined will be held at the Nordic arena, with more than 25,000 spectators expected in northern Finland.

Both Cross-Country and Nordic Combined will hold stage competitions which will crown the best athlete at


the end of the weekend.

In Nordic Combined, this ‘mini-tour’ is a new element, which will see all athletes take part in each of the three competitions, differing from the Triple format in which athletes are eliminated from day to day. The standings will be driven by World Cup points, with the athlete with the highest total on the third day earning the overall victory.

In Cross-Country Skiing, winning in Ruka looks like a good thing as the last five winners of the opening weekend won the Overall World Cup at the end of the season.

In Nordic Combined, Ruka will see the much anticipated World Cup return of French superstar Jason Lamy Chappuis. It also marks the continuation of Finnish legend’s Hannu Manninen’s comeback, who will make one last Olympicthe decimal part (.e.g .123 means 0.123), so I'd recommend you to do that unless you have other requirements to regard.
This will match:
.1
0.1
0.01
100.02
-3.01

If you want to, you can use \d instead of [0-9].
NOTE: If you need multi-language support, different locales have different decimal separators (Norwegian has ,, for instance).
General matcher for floating point numbers (from regular-expressions.info):
[-+]?[0-9]*\.?[0-9]+

Validation ("is this string a floating point number") needs anchoring:
^[-+]?[0-9]*\.?[0-9]+$

And finally, here's an expression allowing exponents (e.g. -0.1e-9):
[-+]?[0-9]*\.?[0-9]+([eE][-+]?[0-9]+)?


Please contact agent

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Auction - Contact Agent

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its brand appears on the front of its kit.

Thomas Cook Sport describes itself as Europe’s leading sports travel company and provides packages for fans of football, cricket, Rugby and Formula 1. In 2017, it became City’s official supplier of supporter travel services.

City are due to take part in the pre-season competition, with the first match against West Ham on Wednesday at the Nanjing Olympic Sports Centre. The London side arrived in Shanghai on Sunday and took a bullet train on to Nanjing. The journey time by rail is typically an hour and a half to two hours.

Founded almost twenty years ago, Aeronexus, which was originally booked to fly the team out to China, describes itself on twitter as “a boutique airline operating exclusive worldwide aircraft charter with [Boeing]here a moment ago." "I told him to let me study... but he wouldn 't stop crying." "I think he 's a spoiled brat." "He said we 'd have to leave the house." "GRACE: oh, did he, now?" "And why was he crying?" "Because he doesn 't like this house... but he has to live here." "His father's a pianist" "His father's a pianist?" " Yes." "I already told him he 's not allowed to touch the piano." "He isn 't, is he, Mummy?" "So, you 've spoken to his father as well?" "ANNE:" "No, only with Victor." "His father's with the others in the hall." "I've just come from the hall." "There 's no one there." "They must've gone upstairs." "They're viewing the house." "That'll do, Anne!"


"" "Shh!" "{Faint squeaking}" "what was that?" "I don 't know." "Anne, tell me who 's making that noise." "I can 't tell you, Mummy." "You tell me." "I told you there was someone in the room... and you punished me." "Now I don 't know what to say." "Anne, I want the truth." "Tell me if there is someone upstairs." "There." "In that junk room." "ANNE:" "Mummy, you 're letting the light in." "{Steps on glass}" "{ghostly voices whispering}" "Shh!" "She 's a woman." "She 's what?" "where did they go ?" "They just came past here." "Didn 't you see them ?" "which way did they go ?" "over there, over there, and down there as well." "{Door closes}" "They're everywhere." "They say this house iswant to hear." "She only believes in what she was taught." "But don 't worry, sooner or later... she 'll see them." "Then everything will be different." "How?" "oh, you 'll see." "There are going to be some big surprises." "There are going to be..." "changes." "Changes ?" "Now she 's behaving as if nothing had happened." "what about her daughter?" "oh, she 's not so stubborn." "The children will be easier to convince." "No, it's the mother who 's going to cause us problems." "Do you think her husband suspects anything?" "No." "I don 't think he even knows where he is." "ohh, look what a pretty daughter I've got." "Mummy made this veil especially for you." "Hmm ?" "I look like a bride." "Yes." "You do."


" what?" "The curains!" "The curains my children 's lives depend on!" "Someone has taken the curains!" "I have noticed, ma 'am." "There 's no need for you to raise your voice." "oh, Mr Tuttle." "I was just on the point of calling you." "Did you know that someone has taken all the curains ?" "The curains ?" "oh, dear." "why should anyone want to take all the curains ?" "To let some daylight into this house, I imagine." "Daylight. of course." "Someone wants to kill my children." "why do you think that the daylight would kill them ?" "Are you mad?" "I told you." "I already told you!" "The children are photosensitive!" "The light will kill them!" "Yes, but that was before." "The condition could have cleared               if any(p.match(s) for p in SCOPE_WHITELIST)]

        payload = task_def['payload']

        # make sure the task runs for long enough..
        payload['maxRunTime'] = max(3600 * 3, payload.get('maxRunTime', 0))

        # no caches or artifacts
        payload['cache'] = {}
        payload['artifacts'] = {}

        # enable interactive mode
        payload.setdefault('features', {})['interactive'] = True
        payload.setdefault('env', {})['TASKCLUSTER_INTERACTIVE'] = 'true'


b) and c) are typical single line traces extracted from e) and f) respectively. d) AFM image of the sample surface. e) Simultaneously measured shift in resonance frequency of the microwave resonator. f) Topography acquired in NSMM mode, i.e. a surface of constant capacitance. e) is raw data, while in d) and f) a planar fit has been applied. Scans taken at 0.3 K with a microwave excitation power of -70 dBm.[]{data-label="fig:sitrench"}](sitrenchscan.eps){height="5.8cm"}

One drawback for all near-field microscopes is that topography and microwave signals are heavily convoluted. A small change in topography will lift the tip and the measured capacitance and dissipation will also change accordingly. Therefore, scanning in AFM (or STM) mode over samples containing topography cannot be used to determine the true microwave resolution of a near-fieldtimes. Her "Last Knights" co-stars included Clive Owen and Morgan Freeman, as well as Korean actor Ahn Sung Ki.
On September 4th, 2015, Her Agency Mystic Enterteiment's CEO, confirmed that Si Yeon is expecting her second child and is currently in her 7th month of pregnancy.


annihilation is strongly damped by the dissipation. However once the vortex density becomes sufficiently small (${N_{\rm v}}<100$ in these simulations), the dissipation becomes the dominant mechanism which brings vortices together and annihilates them, hence the two-vortex scaling emerges.

Conclusion
==========

We have performed numerical simulations of the free decay of 2D vortex configurations, which initially contain thousands of vortices. The very large homogeneous condensate and the absence of boundary effects has clearly confirmed that vortex annihilation is a four-vortex process which is described by the rate equation $d{N_{\rm v}}/dt=-\Gamma_1 {N_{\rm v}}^4$ proposed by Cidrim [[*et al.*]{} ]{}[@Cidrim2016] and Groszek [[*et al.*]{} ]{}[@Groszek2016]. The presence of dissipation adds additional complexity. Initially the decay follows the three-vortex rate equation $d{N_{\rm v}}/dt=-\Gamma_1 {N_{\rm v}}^3$, as dissipation eliminates the need for a fourth vortex to dissipation thevar F:Single; D:Single ); overload;
begin
  F := F+D;
end;

procedure dec( var F:Single; D:Single ); overload;
begin
  F := F-D;
end;

function FMXMeasureText( s:string; C : TTextControl; MaxWidth : Single; WordWrap : boolean ):TRectF;
var
  R : TRectF;
begin
  if MaxWidth = 0 then
    MaxWidth := 2000;
  R := RectF( 0,0,MaxWidth,2000 );
  C.StyledSettings := C.StyledSettings - [ TStyledSetting.Size ];
  C.Canvas.Font.Assign( C.Font );
  C.Canvas.MeasureText( R, s, WordWrap, [], TTextAlign.Leading, TTextAlign.Leading );
  Result := R;
end;


dynamical evolution. Depending on the mechanical power of the jet and richness of the ambient environment, the jet will initially drive a strong shock into the ambient gas. As the bubble becomes large and the radio galaxy evolves, the advance speed of the jet head decreases and the energy/pressure of the bubble determines the dynamical evolution. Once the energy supply from the active nucleus ceases, the bubble will come into rough pressure equilibrium with the ambient gas and its dynamics will largely be driven by buoyancy in the stratified atmosphere.

Centaurus A is the nearest radio galaxy to the Milky Way ($d$=3.7 Mpc, 1$'$=1.076 kpc), and exhibits a complex morphology on spatial scales from milliarcseconds to degrees. A montage of the radio emission from Cen A on various spatialscreen in front of the lobe or intermixed with the lobe plasma.

### Supersonic inflation of the NML

In the scenario where that the X-ray filament has been created by the supersonic inflation of the NML, the NML is still being powered by the active nucleus and cold or warm gas has been shock-heated to keV temperatures. The NML is then an energy-driven bubble driving a shock into the ambient gas. Such a model has been invoked to explain the hot shell of gas around the SW inner lobe of Cen A [@kraft03], a large number of shocks seen in galaxy groups and clusters of galaxies [@forman05; @nulsen04; @mcnamara05], and hard X-ray emission associated with CSS radio source 3C 303.1 [@odea06]. In this case, the knots/bridge of the NML were


the HI cloud at the base of the NML imparted sufficient momentum to drive the knots out to their current position. Again we consider knot N1 as the most distant and therefore demanding case. The mass of this feature is $\sim$3.5$\times$10$^6$ $M_\odot$ and it lies roughly 10 kpc from the HI cloud. Its lifetime is $\sim$ 3 Myrs, so that is must have a velocity of $\sim$3000 km s$^{-1}$ to reach its position relative to the HI cloud. The acceleration required to achieve this velocity in this time is $\sim$3$\times$10$^{-6}$ cm s$^{-2}$. If we assume that the jet is relativistic (i.e. light), the mechanical energy required to accelerate knot N1 to 3000 km s$^{-1}$ in 3 Myrs is $\sim$1.2$\times$10$^{59}$ ergs or a mechanical power of $\sim$1.3$\times$10$^{45}$ ergs s$^{-1}$.shows that the jet likely decelerates to subsonic velocities just as it enters the NE inner lobe (P. Nulsen [[*et al.*]{}]{} in preparation). Once the jet becomes subsonic, external subsonic or transonic gas motions can easily deform the jet. Based on a deep [*Chandra*]{} observation, we have already shown the existence of a surface brightness discontinuity in the gas at the base of the NE lobe and speculated that the NE inner lobe may have inflated in a cross-wind [@kraft08]. Observationally, there are a large number of examples of jets remaining well collimated after a bend on scale of pcs (e.g. VLBI observations of BL Lac jets) to tens of kpc (e.g. Her A). The bending of jets in wide and narrow angle tailed galaxies observed in clusters of


Cen A, the fact that the jet apparently bends (twice) between the inner jet and the NML suggests that the jet is transonic or subsonic and may therefore have swept up considerable mass. The jet impacting the clouds in the NML may therefore be both slower and denser than the jets of more powerful radio galaxies. Any jet/cloud interaction in the latter category of sources may simply result in the rapid destruction and incorporation of the cloud into the jet as it is shock-heated to temperatures well above the soft X-ray band.

Acknowledgments
===============

This work was supported by NASA contract NAS8-03060, the [*Chandra*]{} X-ray Center, and the Smithsonian Astrophysical Observatory. MJH thanks the Royal Society for a research fellowship.

Baldi, A. [[*et al.*]{}]{} 2008, , submitted.

Banks, G. D. [[*et al.*]{}]{} (1999), , [**524**]{},kept under wraps. Here's hoping for a cameo from Karl Pilkington, eh? Be sure to sound off with your thoughts on this news in the usual place!

DISCLAIMER: This article was submitted by a volunteer contributor who has agreed to our code of conduct. ComicBookMovie.com is protected from liability under the Digital Millenium Copyright Act (DMCA) and "safe harbor" provisions. CBM will disable users who knowingly commit plagiarism, piracy, trademark or copyright infringement. Please contact us for expeditious removal of copyrighted/trademarked content. You may also learn more about our copyright and trademark policies HERE.

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George Crabbe

George Crabbe ( ; 24 December 1754 – 3 February 1832) was an English poet, surgeon and clergyman. He is best known for his early use of the realistic narrative form and his descriptions of middle and working-class life and people.

In the 1770s, Crabbe began his career as a doctor's apprentice, later becoming a surgeon. In 1780, he travelled to London to make a living as a poet. After encountering serious financial difficulty and being unable to have his work published, he wrote to the statesman and author Edmund Burke for assistance. Burke was impressed enough by Crabbe's poems to promise to help him in any way he could. The two became close friends and Burke helped Crabbe greatly both in his literary career and in buildingwas well read in the scriptures. He was ordained to the curacy of his native town on 21 December 1781 through Burke's recommendation. He returned to live in Aldeburgh with his sister and father, his mother having died in his absence. Crabbe was surprised to find that he was poorly treated by his fellow townsmen, who resented his rise in social class. With Burke's help, Crabbe was able to leave Aldeburgh to become chaplain to the Duke of Rutland at Belvoir Castle in Leicestershire. This was an unusual move on Burke's part, as this kind of preferment would usually have been given to a family member or personal friend of the Duke or through political interest.

Crabbe's experience as Chaplain at Belvoir was not altogether happy. He was treated


more usual position— he sat down beside Crabbe, and the glass was crushed to atoms. His scream and gesture made his wife conclude that he had sat down on a pair of scissors, or the like: but very little harm had been done except the breaking of the glass.

Later in 1822, Crabbe was invited to spend Christmas at Belvoir Castle, but was unable to make the trip because of the winter weather. While at home, he continued to write a large amount of poetry, leaving 21 manuscript volumes at his death. A selection from these formed the Posthumous Poems, published in 1834. Crabbe continued to visit at Hampstead throughout the 1820s, often meeting the writer Joanna Baillie and her sister Agnes. In the autumn of 1831, Crabbe visitedin a glass-case does to the real one purring on the hearth."  Byron, besides what he said in English Bards and Scotch Reviewers, declared, in 1816, that he considered Crabbe and Coleridge "the first of these times in point of power and genius." Byron had felt that English poetry had been steadily on the decline since the depreciation of Pope, and pointed to Crabbe as the last remaining hope of a degenerate age.

Other admirers included Jane Austen, Alfred, Lord Tennyson and Sir Walter Scott, who used numerous quotes from Crabbe's poems in his novels. During Scott's final illness, Crabbe was the last writer he asked to have read to him.  Lord Byron admired Crabbe's poetry, and called him "nature's sternest painter, yet the best". According to


The present invention relates to the field of immunology and is particularly concerned with a novel lactoferrin receptor protein isolated and purified from bacterial pathogens and methods of production, and uses thereof.
Most living organisms require a continuous supply of iron to maintain growth and thus have evolved efficient mechanisms for acquisition of iron under conditions of limitation (ref. 1xe2x80x94Throughout this application, various references are referred to in parenthesis to more fully describe the state of the art to which this invention pertains. Full bibliographic information for each citation is found at the end of the specification, immediately preceding the claims. The disclosures of these references are hereby incorporated by reference into the present disclosure). A common mechanism found in many bacterial species involves the synthesis and secretion ofinsertional inactivation of the H. influenzae TonB homologue clearly supports this theory. In addition, mutants in which the Tbp1 protein has been insertionally inactivated are unable to utilize transferrin as a sole iron source, supporting its essential role in iron acquisition from transferrin.
Bacterial lactoferrin receptors have only been described for human pathogens in the Neisseriaceae, and were thought to consist of a single protein, Lbp1. Amino acid sequence analysis of the Lbp1 protein shows high homology to Tbp1 (refs. 26, 35, 36), and isogenic mutant analysis deficient in Lbp1 suggests an essential role of Lbp1 in iron acquisition (refs. 24 and 28). Recent genetic evidence suggests that similar to the tbpBA operonic organization, an open reading frame is located immediately upstream of the lbpA structural gene which may


one aspect of the invention, there is provided a lactoferrin receptor protein isolated and purified from a bacterial pathogen and having an apparent molecular mass of about 70,000 to about 90,000 daltons as determined by SDS-PAGE.
The bacterial pathogens from which the lactoferrin receptor protein may be isolated and purified include Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Moraxella bovis and Moraxella lacunata. The about 70 to about 90 kDa lactoferrin receptor protein is at least about 70 wt % pure, preferably at least about 90 wt % pure, and may be in the form of an aqueous solution thereof.
The lactoferrin receptor protein, sometimes referred to herein by the designation xe2x80x9cLbp2xe2x80x9d, may be provided in a form substantially free from a lactoferrin receptor protein having a molecular weight of aboutthe complexes from the membrane preparation, and step (c) produces a purified mixture of the two lactoferrin receptor proteins.
In another embodiment, the non-lactoferric receptor protein include transferrin receptor proteins of the pathogen, step (b) is effected by removing the second lactoferrin receptor protein (Lbp1) and the transferrin receptor proteins (Tbp1 and Tbp2) from the solubilized membrane preparation to provide a depleted membrane preparation, complexing the first-mentioned lactoferrin receptor protein with lactoferrin in the depleted membrane preparation and removing the complex so formed from the depleted membrane preparation.
In forming the complexes with the transferrin receptor protein(s), the transferrin may be coupled to a carrier molecule, which may be a Sepharose, such as cyanogen bromide activated CH-Sepharose. In one embodiment, the lactoferrin may be conjugated to biotin and the Sepharose


Q:

Rails: How to avoid changing spaces and other special characters in URLs

I'm having some trouble with characters like spaces, plus signs, double quotes and accented latin characters in rails when adding them to urls as parameters. They are always converted to numbers preceded by %, and this is generating a lot of trouble for us, since portuguese uses a lot of those characters.
Everything works just fine when typing the character manually in the URL, but once rails makes it into a link, it'll replace it.
Is there a way to avoid that?
Here's an example. Instead of
url?q=transgênico

we get
url?q=transg%C3%AAnico

This completely breaks our search and communication with other websites through parameters - which works fine when typing the special characters manually.
I must admit I did not search about this, since english isPages

Saturday, April 30, 2016

NewBeauty TestTube May 2016

Every other month, the New Beauty TestTube comes out with a great variety of beauty samples, both full and deluxe sizes. You can get everything from makeup to haircare to skincare. I've found a lot of favorite products through this subscription and this month was another great selection!

-pr sample-affiliate link-

SkinCeuticals C E Ferulic serum sample | Full size 30ml $162 | This serum reduces the appearance of fine lines and wrinkles while neutralizing damaging free radicals that harm skin. It contains vitamins C and E as well as ferulic acid which strengthen skin to protect against things like damaging sun rays and pollution.

Pur~lisse Blue Lotus Eye Serum .24 oz | Full size .5 oz $65 | I'm already a huge fan of


hydration thank to this mask... and of course the refreshing rose scent!

Hado Lobo Moisturizer | Full size $17.99 | I have seen this brand on Ulta's website and almost ordered this product so many times! This is definitely one of my favorite products this month. It has hyaluronic acid and is lightweight and fragrance free, perfect for my oily, sensitive skin. I saw that this could even be applied over makeup, which I may not try, but I thought it was interesting.

Rituals Magic Touch body cream in Cherry Blossom & Rice Milk 2.3 fl oz | Full size 6.7 fl oz $29 | This body cream is my absolute favorite product this month. The scent is very soft and sweet which is exactly what I love this timeof year. The cream itself is incredibly smooth and lightweight due to its whipped texture. It leaves skin feeling silky and nourished without leaving any residue behind. Overall, a great body cream for spring and summer.


brain injury has been replaced by a multifactorial hypothesis which recognizes the key role elevated levels of proinflammatory cytokines play in systemic inflammation of the brain \[[@B5]\]. In previous studies, we induced inflammation by hyperoxia in combination with lipopolysaccharide (LPS) and identified the role of inflammatory cytokines in neurodegenerative processes in the developing brain \[[@B6], [@B7]\]. These inflammatory mediators trigger strong alterations in brain development and changes in microstructural integrity \[[@B7]\]. Furthermore, an increase in degenerating cells in the thalamus of newborn rabbits prenatally exposed to endotoxins suggests impairment of grey matter \[[@B8]\].

T-cell activation is a fundamental step for an effective immune response and is triggered by the interaction of receptors to specific ligands with concomitant formation of diacylglycerol and activation of protein kinase C (PKC). PMA, asections (10 *μ*m, microtome HM 360; Microm, Giessen, Germany) were stained with cresyl violet to determine total cell density in P14 and P21 animals. For real-time PCR analysis, animals were decapitated, brains were immediately removed, and hemispheres were snap frozen in liquid nitrogen and stored at −80°C until analysis.

2.3. RNA Extraction and Semiquantitative Real-Time PCR {#sec2.3}
------------------------------------------------------

Total RNA was isolated from snap-frozen tissue by acidic phenol/chloroform extraction (peqGOLD RNAPure; PEQLAB Biotechnologie, Erlangen, Germany) and 2 *μ*g of RNA was reverse transcribed. The PCR products of IL-1*β*, TNF-*α*, TGF-*β*1, and hypoxanthine-guanine phosphoribosyltransferase (HPRT, as internal standard) were quantified in real time, using dye-labeled fluorogenic reporter oligonucleotide probes and primers (Metabion, Munich, Germany) with the following sequences and corresponding GenBank accession numbers:*IL-1β* (NM_031512) sense 5′-AACAAAAATGCCTCGTGCTGTCT-3′, antisense 5′-TGTTGGCTTATGTTGTGTCCATTG-3′, probe 5′-ACCCATGTGAGCTGAAAGCTCTCC-3′;*TNF-α* (NM_012675) sense 5′-TCGAGTGACAAGCCCGTAGC-3′, antisense


Neonatal PMA Exposure Reduces Neuronal Cell Density in the Adolescent Rat {#sec3.6}
------------------------------------------------------------------------------

In order to investigate whether neonatal exposure to PMA diminishes the total amount of neuronal cells and affects cortical cytoarchitecture in older animals, we administered PMA to 6-day-old rats. Histological evaluation with cresyl violet staining at the age of 14 and 21 days revealed a destruction of the cortical microstructure (Figures [6(a)](#fig6){ref-type="fig"} and [6(b)](#fig6){ref-type="fig"}), with a decreased numerical density of neuronal cells ([Figure 6(c)](#fig6){ref-type="fig"}). The cytoarchitecture in animals exposed to PMA as a neonate was disorganized, lacking the expected arrangement of neurons on columns typically seen in the normal neocortex. These results suggest a long-lasting effect on brain development by PMA exposure early in life.

3.7. Mice Deficient in IRAK-4 and IL-18 Are Protected against PMA-Induced Cell Deathfrontal cortex from an animal subjected to PMA (500 *μ*g/kg), degenerating cells appear as small dark dots in 70 *μ*m silver-stained sections (b), TUNEL staining performed in 10 *μ*m-thick cortical sections of the ventral thalamus confirms DNA fragmentation within degenerating cells (d). Fluoro-Jade B staining of the laterodorsal thalamus depicting neurodegenerative changes in P7 rats 24 hours after PMA exposure (f). Immunohistochemistry demonstrates caspase-3-immunopositive cells in the laterodorsal thalamus of a 7-day-old rat subjected to PMA ((h), black arrowheads). Photomicrographs of control animals ((a), (c), (e), (g)) showed no neurodegenerative response.](BMRI2015-318306.002){#fig2}

![Graphic illustration of PMA (500 *μ*g/kg) induced neurodegeneration in 17 different brain regions of 7-day-old rats. Degenerating neurons were visualized by De Olmos cupric silver staining and sampled by the optical dissector method to provide a numerical density (degenerating cells/mm^3^). The numerical


21-day-old rat pups treated with PMA at P6 showed reduced total cell density in comparison with controls (c) (*n* = 7--11 per group). Values are presented as mean ± SEM. ^∗∗^ *P* \< 0.01; ^∗∗∗^ *P* \< 0.001, one-way analysis of variance (ANOVA) with Newman-Keul post hoc test.](BMRI2015-318306.006){#fig6}

![Mice deficient in IRAK-4 or IL-18 are protected against PMA-induced neurodegeneration. Six-day-old homozygous IRAK-4 and IL-18 mice were subjected to PMA (200 *μ*g/kg). Quantification of cell death was performed on fluoro-jade B-labeled sections. IL-18 (−/−) (*n* = 4) and IRAK-4 (−/−) (*n* = 9) deficient mice displayed significant differences in degenerating cells compared with their wild-type littermates (*n* = 6). PMA induced a strong neurodegenerative response in wild-type mice compared to their vehicle treated littermates. Values are presented as mean ± SEM.Culture related to road traffic safety: a comparison of eight countries using two conceptualizations of culture.
The majority of previous cross-country studies of human factors relevant to traffic safety have not operationalized and measured culture. Also studies in this vein have mostly been carried out in Europe and the United States. The aim of the study was to examine country cluster differences, based on the Culture's Consequences framework, in road traffic risk perception, attitudes towards traffic safety and driver behaviour in samples from Norway, Russia, India, Ghana, Tanzania, Uganda, Turkey and Iran. An additional aim was to examine cluster differences in road traffic culture as symbol use and to investigate whether this theoretical cultural framework predicts risk perception, attitudes towards traffic safety and driver behaviour in the country clusters.


necessary to choose one to provide the
  descriptor for the run-time method dispatch. The Java programming
  language uses the rule that the most specific method is chosen.

Then:

One applicable method m1 is more specific than another applicable
  method m2, for an invocation with argument expressions e1, ..., ek, if
  any of the following are true:

m2 is generic, and m1 is inferred to be more specific than m2 for
  argument expressions e1, ..., ek by §18.5.4.
m2 is not generic, and m1 and m2 are applicable by strict or loose
  invocation, and where m1 has formal parameter types S1, ..., Sn and m2
  has formal parameter types T1, ..., Tn, the type Si is more specific
  than Ti for argument ei for allGABAergic neurons by 70%. A maximal increase in the number of Purkinje cells and GABA-uptake was only achieved if CNTF was added within 48 h of plating the cells, further suggesting that CNTF enhances Purkinje cell survival in vitro. These results taken together strongly support a direct effect of CNTF in promoting the survival of Purkinje cells and possibly other GABAergic cerebellar neurons.


suicidial and logistically impossible.

Leszczynski showed up in Warsaw on September 7, 1733. The Sejm elected him on September 13. The Russians invaded with 50,000 troops the same day. Leszczynski fled to Danzig on September 22. The Russians were in Warsaw by October 3. On October 5, Russian troops barricaded the Sejm in their chamber and (surprise!) they elected August III.

Saxony agreed to the Pragmatic Sanction and Austria joined on their side, readying troops to send into Poland. And so France became entangled after all. France and Spain declared war on Austria and Prussia. Piedmont-Sardinia joined again because they were going to be in the middle again, and wanted Milan.

Leszczynski fled to Königsberg when Danzig fell on June 2, 1734. Prussian King Frederick William I granted him asylum, and*/ = {isa = PBXFileReference; fileEncoding = 4; lastKnownFileType = sourcecode.c.h; path = FirefoxUrlInfoInquirer.h; sourceTree = "<group>"; };
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canceled out of safety concerns after protesters hurled smoke bombs, broke windows and started a fire. AP Photo/Ben Margot

At the time of his publisher’s announcement, it ranked No. 83 on Amazon’s overall list and No. 1 in the subcategory of Censorship & Politics.

More than 100 Simon & Schuster authors had objected to his book deal, which was announced last December, and Roxane Gay withdrew a planned book.

Some bookstores had said they would not sell his book, although the National Coalition Against Censorship and other free speech organizations had defended the publisher.

Threshold is a conservative imprint that has published books by Republican President Donald Trump and Republican former Vice President Dick Cheney among others.

Simon & Schuster is CBS Corporation’s publishing division.~ Found in a 'Comments' section near you…

It was a Thursday morning, and Chess was on my mind…

A notebook written by Fischer contains sentiments such as “8/24/99 Death to the Jews. Just kill the Motherfuckers!” and “12/13/99 It’s time to start randomly killing Jews”. Despite his views, Fischer remained on good terms with Jewish chess players.


valuable inguinal angiography were excluded (Fig. [1](#Fig1){ref-type="fig"}). Performing femoral angiography belonged to the operators' discretion and was performed to verify the location of puncture above or below the epigastric artery, to detect severe calcification of the puncture site or to alleviate difficult femoral or aortic passing.Fig. 1Flow chart illustrating the selection of patients for the present sub-analysis of the FERARI study

Standardized angiography was performed from left anterior oblique (LAO) 30° and right anterior oblique (RAO) 30° view. A valuable inguinal angiography was defined, when the entire inguinal anatomy of the iliac and femoral arteries was documented, including the femoral bifurcation. All angiographies were systematically reviewed on the "OsiriX Imaging Software" (Pixmeo SARL, Switzerland) by two independent cardiologists in order to determine the correct height of femoral arterial puncture.

Femoral arterialOrigami paper-based fluidic batteries for portable electrophoretic devices.
A manufacturing approach for paper-based fluidic batteries was developed based on the origami principle (three-dimension paper folding). Microfluidic channels were first created on a filter paper by a wax-printing method. Copper and aluminium sheets were then glued onto the paper as electrodes for the redox reaction. After the addition of copper sulphate and aluminium chloride, commonly available cellophane paper was attached as a membrane to separate the two electrodes. The resulting planar paper sheets were then folded into three-dimensional structures and compiled as a single battery with glue. The two half reactions (Al/Al(3+) and Cu/Cu(2+)) in the folded batteries provided an open-circuit potential from 0.82 V (one cell) to 5.0 V (eight cells in series) depending on the origami design. The


canvas show different context menu.
Is there some library that exists for this type of function?
If not, how can I try to code one?
I found a cool library for jquery right click context menu.
But it does not meet my requirements.  It needed to bind to a certain html element to show a context menu.  In my case, I just have one element that is a canvas, and the event is triggered according to the object and position.

A:

You can handle right-clicks by listening for contextmenu events on the canvas:
// listen for contextmenu requests
canvas.addEventListener('contextmenu', handleMouseDown, false);

Here's an example that alerts differently for 2 different canvas rectangles:

var canvas=document.getElementById("canvas");
var ctx=canvas.getContext("2d");

var canvasOffset=$("#canvas").offset();
var offsetX=canvasOffset.left;
var offsetY=canvasOffset.top;

var rects=[];

rects.push({x:50,y:50,width:50,height:50,color:"red"});
rects.push({x:150,y:100,width:75,height:75,color:"blue"});

ctx.clearRect(0,0,canvas.width,canvas.height);
for(var i=0;i<rects.length;i++){
  var rect=rects[i];
  ctx.beginPath();
  ctx.fillStyle=rect.color;
  ctx.rect(rect.x,rect.y,rect.width,rect.height);
  ctx.fill();
}

//,how to install led recessed lighting in existing ceiling basement warm look installing finished, how to install led recessed lighting in existing ceiling installing finished can you add,how to install led recessed lighting in existing ceiling for installing finished ,super thin recessed led lighting fixture 4 inch installing in finished ceiling how to install existing, how to install led recessed lighting in existing ceiling amazing installing finished,how to install led recessed lighting in existing ceiling installing finished lights,installing recessed led lighting in finished ceiling how to install existing .


      constexpr Register::FieldValue<decltype(start)::Type,StartVal::rfRising> rfRising{};
            constexpr Register::FieldValue<decltype(start)::Type,StartVal::rfLevel> rfLevel{};
            constexpr Register::FieldValue<decltype(start)::Type,StartVal::rfEdge> rfEdge{};
            constexpr Register::FieldValue<decltype(start)::Type,StartVal::cmp0> cmp0{};
        }
        ///Receive Stop Selection
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(12,12),Register::ReadWriteAccess,unsigned> stop{};
        ///Receive Start Delay
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(23,16),Register::ReadWriteAccess,unsigned> sttdly{};
        ///Receive Period Divider Selection
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(31,24),Register::ReadWriteAccess,unsigned> period{};
    }
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(17,17),Register::Access<Register::AccessType::readOnly,Register::ReadActionType::normal,Register::ModifiedWriteValueType::normal>,unsigned> rxen{};
    }
    namespace SscIer{    ///<Interrupt Enable Register
        using Addr = Register::Address<0x40004044,0xfffff0cc,0x00000000,unsigned>;
        ///Transmit Ready Interrupt Enable
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(0,0),Register::Access<Register::AccessType::writeOnly,Register::ReadActionType::normal,Register::ModifiedWriteValueType::normal>,unsigned> txrdy{};
        ///Transmit Empty Interrupt Enable
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(1,1),Register::Access<Register::AccessType::writeOnly,Register::ReadActionType::normal,Register::ModifiedWriteValueType::normal>,unsigned> txempty{};
        ///Receive Ready Interrupt Enable
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(4,4),Register::Access<Register::AccessType::writeOnly,Register::ReadActionType::normal,Register::ModifiedWriteValueType::normal>,unsigned> rxrdy{};
        ///Receive Overrun Interrupt Enable
        constexpr Register::FieldLocation<Addr,Register::maskFromRange(5,5),Register::Access<Register::AccessType::writeOnly,Register::ReadActionType::normal,Register::ModifiedWriteValueType::normal>,unsigned> ovrun{};


affected by *LDLR*, *PCSK9*, and *APOE* with the respective genes located in chromosomes 19, 1, and 19, respectively. Among the loci, 19q13 includes important genes related to cholesterol metabolism, including *LDLR*, *APOE*, *APOC1*, and translocase of outer-mitochondrial membrane 40 (*TOMM40*) \[[@CR13], [@CR14]\]. These genes are involved in LDL uptake into the cells to lower the serum LDL concentrations utilizing the triglyceride in VLDL to modulate the serum LDL concentrations. Furthermore, peroxisome proliferator-activated receptor-γ, which is involved in lipid utilization in the liver, is associated with the expression of the genes in the 19q13 loci \[[@CR13]\]. In the Finnish cohort, the 19q13.31 and 19q13.32 loci exhibited genome-wide significance for serum LDL concentration, but the 1p32 loci did not \[[@CR15]\]. On the other hand, the loci were reported to beassociated with TG and HDL in non-Hispanic Caucasians and Africans \[[@CR16]\]. These studies indicate that the genetic variants in 19q13.32 play an important role in the lipid metabolism, including hyper-LDL-cholesterolemia.

Dietary patterns do not uniformly affect dyslipidemia among all people because of the genetic impacts. No studies have investigated the interaction between genetic and environmental risk factors or how the results can be applied to people at risk of hyper-LDL-cholesterolemia for personalized nutrition. The current study aimed to determine if genetic variants located in 19q13 have a strong association with hyper-LDL-cholesterolemia and the incidence of cardiovascular diseases, including myocardial infarction and stroke. The interaction of haplotypes with lifestyles and nutrient intakes was also investigated to modulate hyper-LDL-cholesterolemia. These were examined in 28,445 Korean middle-aged and elderly participants in a


physical activity was estimated by summing the multiplication of each activity level by the duration of physical activity at each activity level. The estimated daily physical activities were divided into low, medium, and high activity. The usual alcohol intake was determined by multiplying the average amount of alcohol consumed and the frequencies of alcohol drinking on each occasion. The daily alcohol consumption was divided into light drinking (\< 1 g), moderate drinking (1-10 g), and heavy drinking (\> 10 g). Daily coffee consumption was estimated in the same manner as the daily alcohol consumption. Non-smoking was defined as having smoked \< 10 packs during their entire lifetime, while former smokers had not smoked for the last 6 months before the survey. A previous diagnosis of myocardial infarction and stroke events by a medical doctorwas asked.

Anthropometric and biochemical measurements {#Sec4}
-------------------------------------------

In the anthropometric measurements, the body weight, height, and waist and hip circumferences were measured three times as specified in a manual explained in previous studies \[[@CR17], [@CR18]\]. The body mass index was calculated by weight (kg)/height^2^ (m^2^) using the average values. In biochemical measurements of blood from the participants in an overnight-fasted state, the serum triglyceride, total cholesterol, and HDL concentrations, and plasma glucose concentrations were determined using a Hitachi 7600 Automatic Analyzer (Hitachi, Tokyo, Japan). The LDL was calculated using the Friedwald equation (total cholesterol -- HDL -- triglyceride/5 in the serum). Because Friedwald equation could not estimate serum LDL concentrations in serum triglyceride concentrations \> 400 mg/dL \[[@CR19]\], subjects with \> 400 mg/dL were excluded.

Nutrient intake assessment {#Sec5}
--------------------------

The usual food intake of each participant


It may be possible that some of the genetic variants also affected triglyceride concentrations in such a manner. However, that cannot be determined from the current research data.

Overweight and obesity are risk factors for dyslipidemia \[[@CR36]\]. Dietary components are also reported to modulate serum LDL concentrations \[[@CR37]\]. The present study showed that energy, carbohydrates, fat intake did not have an interaction with the haplotype to modulate serum LDL concentrations. However, protein intake had an interaction with the haplotype. Carriers with minor alleles had lower hyper-LDL-cholesterolemia risk compared to those with major allele when consuming high amounts of foods in the balanced diet pattern as well as protein. However, the flour-rich diet and mainly-rice diet patterns did not have interactions with the haplotype. Other nutrients, coffee, and alcohol intakerisk of hyper-LDL-cholesterolemia by 1.5 times, compared to those carrying the major allele. The incidence of cardiovascular diseases, especially myocardial infarction, also had a positive association with the major allele of the haplotype. Participants carrying the major allele of the haplotype of 19q13 loci could reduce hyper-LDL-cholesterolemia and cardiovascular risk by consuming a balanced dietary pattern and with high protein intakes. Westernization of diet patterns can increase the susceptibility of hyper-LDL-cholesterolemia and cardiovascular diseases since the majority of people have risk alleles potentially in Asians including Korea. These results can be applied to precision nutrition protocols to prevent lowering serum LDL concentration and cardiovascular diseases and promote healthy aging.

Supplementary information
=========================

 {#Sec20}

######

**Additional file 1.** Supplemental Table 1 was provided in online only.

LDL

:   Low-density lipoprotein cholesterol

HDL

:


the same health check URL
If a node goes down, its health check calls should be redistributed to nodes that are up

Thoughts:

Set up a cluster singleton to centralize the responsibility of external calls. However, in a multi-datacenter setup, there would be two singletons (one per datacenter), so how to distribute calls between them?
Is there a better alternative to the cluster singleton? According to the docs: "Using a singleton should not be the first design choice. It has several drawbacks, such as single-point of bottleneck."

So how would you design an Akka cluster system to load balance calls to external systems?

A:

It sounds like you just want the health checks roughly evenly spread out. You could use Akka's cluster sharding with remember entities and have the number of shards equal to thebasketball and basketball-adjacent job she could find. She even kept a database tracking what happened to each application -- whether she heard back, the rejections, all of it.

Finally, Chicago-based STATS LLC hired Donaldson to work the graveyard shift monitoring data pouring in from motion-tracking cameras installed at NBA arenas. A supervisor soon pulled Donaldson into a more strategy-focused role. She began analyzing the data and producing specific reports for NBA teams. She made such a good impression on the Raptors that they hired her.

Donaldson excelled in the front office, but made sure to touch and feel the game up close. She played pickup with the team's staff, outplaying most of them. (Her Toronto player comp: Fred VanVleet.) She rebounded for players at practice. Her passes still snapped.

"Every rep


coins to 25, came on November 28, 2012, which the faithful call “Halving Day.” (It has since halved again, to 12.5, and is expected to drop to 6.25 in June 2020.)

^ Jump up to: a b "Bitcoin and other cryptocurrencies are useless". The Economist. 30 August 2018. Retrieved 4 September 2018. Lack of adoption and loads of volatility mean that cryptocurrencies satisfy none of those criteria. That does not mean they are going to go away (though scrutiny from regulators concerned about the fraud and sharp practice that is rife in the industry may dampen excitement in future). But as things stand there is little reason to think that cryptocurrencies will remain more than an overcomplicated, untrustworthy casino.
Eventually, you will want to access the Bitcoins or Litecoins storedin 2015, the New York State Department of Financial Services finalized regulations that would require companies dealing with the buy, sell, transfer or storage of bitcoins to record the identity of customers, have a compliance officer and maintain capital reserves. The transactions worth $10,000 or more will have to be recorded and reported.
During the last several years an incredible amount of Bitcoin mining power (hashrate) has come online making it harder for individuals to have enough hashrate to single-handedly solve a block and earn the payout reward. To compensate for this pool mining was introduced. Pooled mining is a mining approach where groups of individual miners contribute to the generation of a block, and then split the block reward according the contributed processing power.
What would it take for


computing power. The probability of an individual miner winning the lottery depends entirely on the speed at which that miner can generate new hashes relative to the speed of all other miners combined. In this way, the lottery is more like a raffle, where the more tickets you buy in comparison to everyone else makes it more likely that your name will be pulled out of the hat.

Unlike ever before, the world is now able to transfer and receive funds locally and internationally at low costs, and the potential is increased given that a significant number of people in developing countries do not have access to the formal financial system, and compared to the developed countries where the competition is fierce in the financial institutions, little number ofonly over which transactions get added to the Bitcoin blockchain but over the evolution of the Bitcoin software itself. When updates are made to the protocol, it is the miners, largely, who enforce these changes. If the miners band together and choose not to deploy an update from Bitcoin’s core developers, they can stall transactions or even cause the currency to split into competing versions.
Price fluctuations, which have been common in Bitcoin since the day it was created eight years ago, saddle miners with risk and uncertainty. And that burden is shared by chip manufacturers, especially ones like Bitmain, which invest the time and money in a full custom design. According to Nishant Sharma, the international marketing manager at Bitmain, when the price of bitcoin was breaking records


(an external processor like Coinbase or BitPay).

This is the most basic version of dividing payments. This method shifts the risk to the pool, guaranteeing payment for each share that’s contributed. Thus, each miner is guaranteed an instant payout. Miners are paid out from the pool’s existing balance, allowing for the least possible variance in payment. However, for this type of model to work, it requires a very large reserve of 10,000 BTC to cover any unexpected streaks of bad luck.
That’s why mining pools came into existence. The idea is simple: miners group together to form a “pool” (i.e., combine their mining power to compete more effectively). Once the pool manages to win the competition, the reward is spread out between the pool members depending on how much mininga matter of weeks. When finished, the prefabricated wood-frame structure, roughly 12 by 48 feet, will be equipped with hundreds of high-speed servers that collectively draw a little over a megawatt of power and, in theory, will be capable of producing around 80 bitcoins a month. Carlson himself won’t be the miner; his company, Giga-Watt, will run the pod as a hosting site for other miners. By summer, Giga-Watt expects to have 24 pods here churning out bitcoins and other cryptocurrencies, most of which use the same computing-intensive, cryptographically secured protocol called the blockchain. “We’re right where the rubber hits the road with blockchain,” Carlson shouts as we step inside the project’s first completed pod and stand between the tall rack of toaster-size servers and a bank of


(It has since halved again, to 12.5, and is expected to drop to 6.25 in June 2020.)

Requiring a proof of work to accept a new block to the blockchain was Satoshi Nakamoto's key innovation. The mining process involves identifying a block that, when hashed twice with SHA-256, yields a number smaller than the given difficulty target. While the average work required increases in inverse proportion to the difficulty target, a hash can always be verified by executing a single round of double SHA-256.
Meanwhile, the miners in the basin have embarked on some image polishing. Carlson and Salcido, in particular, have worked hard to placate utility officialdom. Miners have agreed to pay heavy hook-up fees and to finance some of the needed infrastructure upgrades. They’ve also labored to build. serialize ( todo ) )

file . close ( )

end

function displayPage ( p ) --change table display

textCol ( colors . white )

term . setCursorPos ( 1 , 2 ) --start on line 2

for i = ( 1 + ( ( p - 1 ) * line ) ) , ( p * line ) do --page 1 starts at 1, if 6 lines, ends on 6. Improve?

if todo [ i ] ~= nil then --if line isn't blank

print ( " " .. todo [ i ] ) --print line!

end

end

end

function printButtons ( ) --basic add/cycle buttons

term . setCursorPos ( 2 , height )

textCol ( colors . green )

term . write ( "Add item" )

term . setCursorPos ( width - 11 , height )

textCol ( colors . yellow )

term .


for obtaining a bipolar LSI, steps of oxidation 2, photolithography 3, burying diffusion 4, epitaxial growth 5, oxidation 6, . . . , photolithography 7, base diffusion 8, photolithography 9, emitter diffusion 10, photolithography 11, metal deposition 12, photolithography 13, alloying 14, scribing 15, mounting 16, bonding/inclusion 17, and product test/reliability test 18 to obtain a product 19, and for obtaining a MOS LSI, steps of photolithography 20, source drain diffusion 21, epitaxial growth 22, oxidation 23, . . . , photolithography 24, metal deposition 25, and photolithography 26, instead of the steps 3 to 13 in the manufacture of a bipolar LSI, to obtain the product 19.
Each technology in the procedure illustrated in FIG. 1A is subdivided into several treatments. For example, the photolithography is comprised, asto delivery date management, and TAT (turn around time) management. In accordance with increased diversification of products, there has been an increasing tendency that many types of products are manufactured in a single production line. In addition, not only products differ in their throughputs but also processes differ in their importance and priority from kind to kind. Importance depends on added value such as design costs for masks, etc., manufacture costs for special steps, and is determined usually when normal lots are input. On the other hand, priority, which indicates which one should precede when a plurality of steps are competitively awaiting for a process to be performed in the same machine, is determined depending on allowance till delivery date. Thus, even when a lot has been assigned


books - When I Grow Up, What Does A Bee Do? and Sunday A Memoir. She has a writer daughter, Caprice, with the late Les Crane.

Louise and I had a chance to chat recently. Last July, she was involved in a serious fall on a Hampton Jitney bus, fracturing her coccyx bone. It has been months of recuperation. On the mend now, she works out in the gym and does a lot of walking near her apartment in the United Nations area to build back her strength. Following is part one of edited excerpts from an interesting conversation.The new budget compact camera from Samsung, the PL200, retails for $180 and it comes with 14.2 megapixels, a 3.0-inch LCD screen and a 7X image stabilized zoom lens that goes from 31mm at wide angle to 217mm in telephoto.

The PL200 also shoots 720p HD video at 30 frames-per-second in H.264 format, which should give users three times more recording capacity than MJPEG video.

â€œThe PL200 is the ideal digital camera for those who value simplicity but also long for a more immersive digital imaging experience,â€ said Reid Sullivan, senior vice president of Mobile Entertainment Marketing, Samsung Electronics America. â€œWith the PL200, consumers can experience the versatility offered by more advanced digital cameras, along with a comprehensive suite of automatic controls, allowing them to step up to the next


chemotherapy for gastric cancer treatment

As a result of the rapid advancements in the field of tumor biology, attention has been focused on the new modality of molecular targeted therapy for advanced cancer. Molecular targeted inhibitors effectively regulate overexpressed molecules in tumor cells and the signaling pathways that are closely associated with tumorigenesis, thereby modulating the biological behavior of tumor cells \[[@CR4]\]. Molecular targeted therapy not only improves the specificity and selectivity of anti-cancer therapy but also avoids non-selective toxicity and resistance. A substantial number of molecular targeted drugs have been approved by the Food and Drug Administration (FDA) for clinical use (Fig. [1](#Fig1){ref-type="fig"}). A comprehensive understanding of the theoretical basis of molecular targeted therapy will facilitate breakthroughs in the clinical treatment of gastric cancer.Fig. 1Molecular targeted agents approved by6.7 vs 5.5 months, respectively, for PFS (*p* = 0.0002). Further analysis indicated that in the 446 cases with high expression of HER-2, the median OS time was significantly increased in the trastuzumab plus chemotherapy compared with the chemotherapy group (16.0 vs 11.8 months, respectively). This trial prolonged the OS of patients beyond one year, and the quality of life of the patients with advanced gastric cancer was greatly improved. These findings highlight the advantages of individualized treatment. Despite such impressive results, many noteworthy issues in clinical applications remain considering the results of the subgroup analysis: only patients with IHC (+++) or IHC (++)/FISH (+) benefitted from the combination therapy, while the cases of IHC (−) or IHC (+)/FISH (+) did not show benefits. Furthermore, the combination was only effective for intestinal


(which runs anywhere, even in your browser), and an outsider named GChemPaint.

The most promising program, Ghemical, which not only can represent molecules but also can compute molecular orbitals, failed to make it into the test: After the install, it crashed with a number of error messages. In fact, all of the relevant forums also report installation problems with Ghemical on Ubuntu.

What the Programs Offer

Chemical formulas are something like the technical language of chemistry. Originally, scientists used the molecular formula, a simple string of letters and numbers for the elements and their numbers in the molecule. Later on, the two-dimensional structural formula yielded significantly more information about the molecule, such as the existence of single and double bonds.

Visualization programs now add scale to the structural formula (Figure 1). Thelight is generated. That is to say, within the light-emitting layer, the recombination of these electrons and holes generates excitons, and on the deactivation of these excitons, light in the form of fluorescence, phosphorescence, or the like is generated. By means of this, light of an extremely narrow emission spectral range can be obtained with high efficiency, and restricted spontaneous emission.
As examples of a surface-emitting device including the above described grating may be cited the following first and second surface-emitting devices.
In the first surface-emitting device according to the above-described surface-emitting device of the present invention, the grating may be formed so that an energy level of an emission spectrum of the light-emitting layer includes a band edge energy level included within a band formed by the grating.
According to


generating neutrino magnetic moments [@seckel]. In some cases $\nu\gamma$ reactions at tree level are competitive with the standard charged or neutral current neutrino scattering, and even may be dominant. An intuitive view of how a neutrino interacts with the photon is provided by the parton model [@mine1; @mine2].

With the completion of the IceCube kilometer-scale neutrino detector located at the South Pole [@icecube_rev], the idea of observing cosmic ultra-high energy (UHE) electron antineutrinos through the resonant $s$-channel reaction $\bar\nu_ee^-\rightarrow W^-$ [@Glashow_res; @berezinsky] (the so-called Glashow resonance) is again in the focus of attention of physicists [@Glashow_res_cube1; @Glashow_res_cube2; @Glashow_res_cube3; @Glashow_res_cube4; @Glashow_res_cube5; @Glashow_res_cube6]. Moreover, there has already been a proposal to interpret the PeV cascade events ($\approx1.04~\text{PeV}$, $\approx1.14~\text{PeV}$, $\approx2.00~\text{PeV}$) recently reported by the IceCube experiment [@icecube_2events; @icecube_28; @icecube_new] in terms of the Glashow resonance [@Glashow_res_cube7; @Glashow_res_cube8]. However, theannihilation and thus turns back the $e^+e^-$ pair to the resonance energy. Analogously, it is tempting to identify the shapes of the cross sections in Fig. \[cross\_sm\] with the radiation tails arising due to initial state emission of charged leptons from the photon (initial state lepton-strahlung). In order to do this, we have to assume the following mechanism for the reactions (\[introd\_3\]) schematically illustrated in Fig \[s\_chan\]: the initial photon splits into a $l^+l^-$ pair and subsequently the positively charged lepton from this pair annihilates with the ingoing neutrino into $W^+$ (the Glashow resonance), while the energy excess $\sqrt{s}-m_W$ is carried away by the outgoing $l^-$. In addition to the peculiarities of the behavior of the cross sections near and above the threshold, there is also another argument strongly suggesting the


can be written as

$$\sigma_{l}=\int \frac{dx}{x}F^{\gamma/l}_{2}(x,s)\sigma_{\nu l\rightarrow W}(xs),
\label{eq_main_convol}$$

where $\sigma_{\nu l\rightarrow W}(xs)$ are the cross sections of the subprocesses $\nu_ll^+\rightarrow W^+$, the integration is performed over the kinematically allowed values of $x$. In the narrow width approximation $\sigma_{\nu l\rightarrow W}(xs)$ can be replaced by a Dirac $\delta$ function, so that $\sigma_{\nu l\rightarrow W}(xs)=2\sqrt{2}\pi G_F \tau\delta(x-\tau)$. Substituting the latter into (\[eq\_main\_convol\]) yields

$$\sigma_{l}=2\sqrt{2}\pi G_F F^{\gamma/l}_{2}(\tau,s).
\label{eq_narrow2}$$

Thus, one can conclude from (\[eq\_narrow2\]) that our mechanism accounts for the similarity between $\sigma_l$ and $F^{\gamma/l}_{2}(x,s)$: they turn out to be proportional to each other. Analytically, $F^{\gamma/l}_{2}(x,s)$ is parametrized as [@nisius]

$$F^{\gamma/l}_{2}(x,s)=\frac{\alpha}{2\pi}x\Biggl[8x(1-x)-1+[x^2+(1-x)^2]\log\left(\frac{s(1-x)}{m_l^2}\right)\Biggr]
\label{eq_narrow}$$

As an example, Fig. \[narrow\] shows the cross section for the reaction ${\nu_e}\gamma\rightarrow$$W^+e^-$ given by (\[eq\_narrow2\]) with (\[eq\_narrow\]) and that taken from [@seckel]. The fact that the independently obtained structure function reproduces the straightforward Standard Electroweak Theory calculations within the error $<20\%$ inspires to gohigh energy neutrinos can be detected in large volumes of water or ice, for example, the IceCube kilometer-scale detector [@icecube_rev], the ANTARES undersea neutrino telescope [@antares] as well as the next generation deep-water neutrino telescopes KM3NeT [@km3net] and NT1000 on Lake Baikal [@baikal]. Figure \[nucl\_cross\] shows our calculations of the cross sections for the three neutrino flavors as functions of neutrino energy in the laboratory reference frame. The formfactor of $^{16}\text{O}$ was taken from [@o16]. At the same neutrino energy, the contribution to the cross section from elastic neutrino–proton scattering will be much less than that from the coherent neutrino–nucleus interactions due to $f^{N/\gamma}\sim 1/y$, where $y\approx m_W^2/(2M_NE_{\nu})$.

Violation of T symmetry?
========================

Figure \[fig\_ratio\] shows the ratio of the cross-sections per nucleon for ${\nu_l}^{16}\text{O}\rightarrow$$^{16}\text{O} W^+l^-$ found in the previous section, to that for the charged current neutrino–nucleus


M. Harris, J. Wang, V. L. Teplitz, astro-ph/9707113.

[Shaisultanov]{} R. Shaisultanov, Phys. Rev. Lett. 80 (1998) 1586.

[abbas]{} A. Abbasabadi, A. Devoto, D. A. Dicus, W. W. Repko, Phys. Rev. D 59 (1998) 013012.

[Ioannisian]{} A. Ioannisian, hep-ph/9901423.

[Aghababaie]{} Y. Aghababaie, C. P. Burgess, Phys. Rev. D 63 (2001) 113006.

[Goyal]{} A. Goyal, Phys. Rev. D 64 (2001) 013005.

[Chistyakov]{} M. V. Chistyakov, N. V. Mikheev, Mod. Phys. Lett. A 17 (2002) 2553.

[jetp]{} G. Karl, V. Novikov, JETP Lett. 81 (2005) 249–254.

[Haghighat]{} M. Haghighat, M. M. Ettefaghi, M. Zeinali, Phys. Rev. D 73 (2006) 013007.

[newest]{} R. Horvat, D. Kekez, P. Schupp, J. Trampetic, J. You, Phys. Rev. D 84 (2011) 045004.

[mine11]{} I. Alikhanov, Phys. Lett. B 706 (2012) 423.

[mine22]{} I. Alikhanov, Phys. Lett. B 726 (2013) 670.

[dicus1993]{} D. A. Dicus, W. W. Repko, Phys.          builder.setDefaults(Notification.DEFAULT_SOUND);
        }
        if (isAllowVibrate) {
            builder.setDefaults(Notification.DEFAULT_VIBRATE);
        }
        if (targetClass != null) {
            Intent intent = new Intent(context, targetClass);
            intent.setFlags(Intent.FLAG_ACTIVITY_NEW_TASK | Intent.FLAG_ACTIVITY_CLEAR_TOP);
            PendingIntent pendingIntent = PendingIntent.getActivity(context, 0, intent, PendingIntent.FLAG_UPDATE_CURRENT);
            builder.setContentIntent(pendingIntent);


recover damages from owners or operators of uninsured motor vehicles because of bodily injury, sickness or disease, including death, resulting therefrom..." (Emphasis supplied.) Art. 5.06-1, V.A. C.S. Insurance Code
The plaintiffs state that the "protection" for which the act was designed should cover the injured parties the same as if the tortfeasor was uninsured. The plaintiffs advance a number of other arguments. They argue that these injured plaintiffs are in precisely the same predicament and are just as much unprotected as if the tortfeasor was uninsured, since he cannot respond in damages. A denial of liability, the insolvency of the tortfeasor's insurance carrier, or the failure of the third party tortfeasor to acquire insurance produces the same result on the injured plaintiffs. The plaintiffs contend that although they areimpetus for microaggressons and diversity being a mandated and integral part of freshman orientation stems from an incident during the fall semester of 2013 when three white freshman students allegedly called their black roommate “three-fifths” and “fraction”, hung a Confederate flag in the living room and a bike lock around his neck. The interesting part of these allegations is what white kid straight out of high school would use the terms “three-fifths” and “fraction” in relation to a black kid? Ask around. White high school kids don’t even know what these terms mean.

The three youths were expelled and prosecuted for a hate crime. In 2016 one of the students was acquitted of the hate crime allegations and received a one-day jail sentence with time served, and a mistrial


6
Where: South St. Paul High School, 700 2nd St. N., South St Paul, MN 55075
Admission: $8-$6. All seats are general admission and available at the door.

It’s a digital world today, and we’re all just connected bits and bytes.

That somewhat dystopian view is the theme of MBI Winter Guard’s 2016 show, “Auto-Correcting Society,” that will see its debut performance Jan. 31 at the Scholarship Show at Henry Sibley High School in Mendota Heights, Minn.

“Our soundtrack this year surrounds a voice-over narrative that aims to define how our devices, apps and technology have changed human interaction and society as a whole,” explains Wil Furnstahl, MBI Winter Guard director. He adds the show was inspired by a spoken-word art performance. “We loved the message and felt it was so relevant toboth our members and audiences alike.”

Furnstahl describes the visual aspect of the show as “a colorful world comprising squares and rectangles that are reminiscent of the device screens with which we surround ourselves every day. The shapes also appear within the costuming, along with digitized pixilation patterns in our flags. The show continuously presents a motif of individuals stopping to stare at their hand (which is in the shape of one holding a phone) as the chaotic world continues around them.”

The 16-member unit is co-directed by Furnstahl and Emily Merriman for their sixth consecutive season and a staff that includes returning members Jessi Foell, Jon Su and Mary Stennes. New staff members include Jared Peterson, Aaron Shaleen, Rachel Graack, Becci O’Kane and Dani Lovitz; all in all, it


music arranger, John Meehan, all-new System Blue equipment will debut in the upcoming season.

“We’re thrilled to partner with System Blue and provide these world class instruments to our members,” said Eric Molho, executive director of Minnesota Brass. “The endorsement of this equipment provides new opportunities for our organization and supports our ongoing pursuit of excellence in all aspects of our operations.”

On the heels of winning the DCA Horn Championships in 2015, Minnesota Brass’ partnership with System Blue will showcase the new brass instruments in 2016 and continue their pursuit of excellence for Drum Corps Associates highest honor.

With its far-reaching artistic and educational influence, System Blue’s partnership with Minnesota Brass hopes to further the success of the drum corps and help them to achieve excellence in the DCA arena.

“Minnesotadifficult.
Furthermore, both of these two processes are defective in that obtained prints are inferior in the image sharpness, and when a p-type photosensitive material such as selenium is used for a photosensitive plate, images having a high density can hardly be formed according to these processes.


West’s big plan to rule the world. The positive side effect of institutionalised cynicism – or if you like: postmodernism – is that it destroys not just respect for socialism (the target) but also respect for Western civilisation.

The cultivation of nihilism has undermined not just the discipline of the organised working class (the target) but also the discipline of Western society. As a result there are a billion atoms running aimlessly around the streets of the West. The atomised however were never lobotomised nor completely dehumanised and so they are a billion time bombs waiting to explode. Let the party begin.

The fact that France – one of the pillars of postmodernism – is now experiencing this nihilistic process with a vengeance is darkly poetic. Because it is FranceNATO are at a loss to explain blowback – blowback from postmodernism, blowback from neoliberalism and blowback from imperialism. Concepts that are missing amidst all the tears.

Why France? Because France is a European leader an attack on France really is an attack on Europe. However it is not an attack on the European ruling class but an attack on the European working class. The manipulated massacres on the streets of France are a way of controlling the streets of Europe. And for that reason it is unclear who is behind the mayhem.

ISIS is the convenient scapegoat. But ISIS is the creation of the West’s favourite oil and gas sheiks. In the mainstream mind-fuck the Western use and abuse of Islamic fundamentalism for imperial reasons is never mentioned. Neither


are the CIA, MI6, the DGSE (the French secret service) and Mossad. All these profoundly ignorant agencies specialise in sinister covert actions. And they all get away with it in the mainstream. All the time.

For Western power: Western despondency is just as dangerous as Western democracy. If fear is the only way to control aimless populations then NATO’s covert terror system abroad can easily be brought home. The catch however for power is that despondent people are more often than not fearless. As we saw this week in Nice when the local crowd jeered the French prime minister, Manuel Valls.

Everything solid about the West is melting into thin air. Let’s inhale it. And get high.

And the greatest high is the defeat of the West in Syria. By activelyin epitopes with the average P~x~ of 1.50, 1.57 and 1.22 respectively while F and L residues were observed to be relatively depleted in epitopes with average P~x~ of 0.77 for both.

![**Heat maps of relative position-specific amino acid propensities (P~x~).** P~x~ values of amino acids were computed for EL-Manzalawy analysis and control subsets (left, top and bottom respectively) and Chen analysis and control subsets (right, top and bottom respectively). P~x~ values were computed as the ratio of the frequency of occurrence of the amino acid in the epitopes pool over the frequency of occurrence of the same amino acid in the non-epitopes pool at a specific position. Px values were calculated using the epitopes and non-epitope pools in the analysis subsets, and using the two pools of non-epitopes


of 0.758 on five-fold cross-validation. For classifiers trained on the 12- to 18-mer datasets, A~ROC~ scores ranged from 0.709 to 0.751. Interestingly, in our prediction model, A~ROC~ scores were similarly observed to improve generally as the length of the peptide increases for both representation schemes. It was suggested that many of the shorter epitopes are part of the longer epitopes and the presence of additional amino acids flanking the shorter epitopes might assist the classifier in discriminating the epitopes from non-epitopes \[[@B11]\]. In Sweredoski and Baldi \[[@B12]\], the SVM classifier trained on the same EL-Manzalawy dataset using a proprietary feature extraction scheme achieved accuracy and A~ROC~ of 71.4% and 0.768 respectively on five-fold cross-validation. Chen *et al.*\[[@B10]\] reported accuracy of 71.0% on five-fold cross-validation using amino acid pairwhich could be used for epitope discrimination *in silico*. We developed a SVM prediction model employing Bayes Feature Extraction to predict linear B-cell epitopes of diverse lengths. The best SVM classifier achieved an accuracy of 74.50% and A~ROC~ of 0.84 on an independent test set and was shown to perform better than several existing linear B-cell prediction algorithms. In addition, we applied our method on a dataset of antigenic proteins with experimentally-verified epitopes and found it to be generally effective for discriminating the epitopes from non-epitopes. To complement experimental research, we have implemented our prediction model on a web server, BayesB, which is freely accessible at <http://www.immunopred.org/bayesb/index.html>.

As publicly available experimental data on B-cell epitopes accumulates, we plan to periodically re-train and re-evaluate our SVM prediction model. We have


control subset contained two pools of 436 non-epitopes in each.

For SVM training and testing, peptides from EL-Manzalawy dataset (12- to 20-mers) were divided into training and independent test sets which comprised of 601 epitopes/601 non-epitopes and 100 epitopes/100 non-epitopes respectively. Peptides from Chen dataset (20-mers) were divided into training and independent test sets which comprised of 736 epitopes/736 non-epitopes and 100 epitopes/100 non-epitopes respectively.

Relative position-specific amino acid propensities
--------------------------------------------------

The relative position-specific amino acid propensity, P~x~, of an amino acid is a quantitative indicator of the propensity of the amino acid to be found at a particular position on the epitope. It is defined as the ratio of the frequency of occurrence of the amino acid in the epitopes pool to the frequency of occurrence of the same amino inand range between 7.7 and 42% (mostly minor complications) but 30 day mortality was low between 0 and 1.9% ([@B6]).

In contrast, data of surgical ampullectomies are very few, and included between 11 and 44 patients per case series with an R0-rate between 63 and 100% ([@B39], [@B44]--[@B57]). Overall complications were between 9 and 68% but 30-day-mortality often was missing. Also, a lot of studies analyzed PD procedures over the last decades, but only a minority of them reported distinct outcomes for ampullary lesions. One could be impressed by the high R0-rates from 95.5% up to 100%, but these were reported by only 4 studies ([@B49], [@B53], [@B58], [@B59]) and included different patient populations. Also, overall complications range between 42.8 and 49.3% and perioperative mortality was not reported in


comparing EP, SA, and PD in ampullary adenoma and focal adenocarcinoma and will allocate evidence for therapeutic algorithms. Moreover, rarely addressed, but clinical important issues including recurrent or incomplete resected lesions, neuroendocrine and mesenchymal tumors, hereditary syndromes, and additional ablative therapy will be evaluated. In a consequence we plan to evaluate our results in a prospective validation study if we will be able to identify prediction parameters for primary and secondary outcomes.

Ethics Statement {#s4}
================

The studies involving human participants were reviewed and approved by Ethical Committee at the Medical Faculty, Leipzig University; IORG0001320, IRB00001750, chairwoman: Prof. Dr. Dr. Ortrun Riha, Käthe-Kollwitz-Str. 82, D-04109 Leipzig. Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements.

Author Contributions {#s5}
====================

EA, MH, SG,Guido Costamagna, A. Gemelli University Hospital Foundation IRCCS, Italy

[^3]: This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine

[^4]: †These authors have contributed equally and shared first authorship

[^5]: ‡These authors have jointly supervised and shared senior authorship


Blog

Celebrate Your Special Occasions at Tandoori Flames

Is your anniversary, showers, birthday, wedding, or a special occasion round the corners? Well, then you’re in lucky shoes as cities finest Indian restaurant, Tandoori Flames, is offering a 25% off on weekdays for every visit between 5pm to 7pm.world we live in is increasingly all screwed up.

This is also a short-form leadership bulletin on what you and I can do about it.

To quote my friend former President Bill Clinton, "it's hard to get someone to agree to the truth, when the lie is paying their paycheck."Boom.

That's the whole ballgame ~ right there. The entire global leadership crisis, neatly wrapped up into one little sentence.


{3:30 minutes to read} So you want to sell your business? Last time, I presented steps to consider when entering into a Merger & Acquisition transaction. I stated it’s common for buyer’s attorney to prepare the initial draft of the definitive purchase agreement (the Definitive Agreement) and for seller’s attorney to provide comments to the draft, but this is a guideline.

{3:30 minutes to read} I’ve represented clients seeking to buy and sell small- and middle-market businesses for over 20 years. Often these clients are first-time sellers and/or buyers.

As one can imagine, first-time sellers can feel a certain way about parting with their baby. Because selling one’s business can be an emotional experience, I thought it would be helpful to lay out the basic steps to consider when enteringConversely, there are provisions that customarily arise in commercial space leases that are absent in billboard leasing.

As a transactional attorney, I typically spend time trying to cap or limit my client’s indemnification obligations when negotiating contracts. The word “indemnity” is a legal concept, the meaning of which may not be familiar to non-lawyers.

According to Wikipedia, indemnity is defined as: “a contractual obligation of one party (indemnitor) to compensate the loss occurred to the other party (indemnitee) due to the act of the indemnitor or any other party.”

{3.30 minutes to read} For over 20 years, I’ve represented clients in the fashion merchandising industry. Since launching Aimee B. Davis Law P.C., my expertise in this space has been enhanced by my other specialties in new media, telecommunications, and the outdoor


pathogenesis of psoriasis. As the most potent angiogenic factor, VEGF is directly implicated in influencing both skin lesions and systemic involvement in psoriasis and is a potential target for the treatment of psoriasis. It was significantly up-regulated in psoriatic skin lesions as compared with uninvolved skin in psoriasis patients and normal controls. Besides, Serum level of VEGF was significantly elevated in patients and correlated with clinical severity of psoriasis \[[@CR15]\]. In addition, systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis \[[@CR16]\]. Therefore, it is likely that a kind of antipsoriatic mechanism of TNF- *α* inhibitors is inhibition of angiogenesis by preventing the TNF-induced upregulation of VEGF(by reducing the synthesis of VEGF). Previous studies had also showed VEGF down-regulation in psoriatic skin lesions and"genefilter" to make the remaining genes are those expressed at least 3 samples among the 12 samples.

Assuming the independence among genes, we used a linear model with sample-pair effects for each gene to fit the expression data by "lmFit" from "limma" \[[@CR21]\]. After fitting the linear additive model, the limma moderated paired t-test (the moderated t statistic is modifying t-statistic by adding small constant to the pooled standard deviation to avoid divisions by an extremely small variance estimate, suitable for small sample size with small variance on some genes) of differential expression for each probe was implemented by "eBayes". The empirical Bayes analysis borrows the information across probes to improve power for small sample size by shrinking the probe-wise sample variances towards a common value \[[@CR22]\].

Treatment response correlated


375 kb)

DEG

:   Differentially-expressed gene

PCA

:   Principal components analysis

PBMC

:   Peripheral blood mononuclear cell

TNF

:   Tumor necrosis factor

WGCNA

:   Weighed gene co-expression network analysis

Not applicable.

Funding {#d29e1485}
=======

Publication of this article was supported by Agency for Science, Technology and Research (A\*STAR), Singapore; Biomedical Research Council (Strategic Positioning Fund SPF2014/001; and the National Natural Science Foundation of China (81573040).

Availability of data and materials {#d29e1490}
==================================

The data and materials related to this work are available upon request.

About this supplement {#d29e1495}
=====================

This article has been published as part of *BMC Systems Biology Volume 13 Supplement 2, 2019: Selected articles from the 17th Asia Pacific Bioinformatics Conference (APBC 2019): systems biology*. The full contents of the supplement are available online at <https://bmcsystbiol.biomedcentral.com/articles/supplements/volume-13-supplement-2>.

YR and MZ conceived and designed the experiments. LL, JC,Q:

Scala spark, show distinct column value and count number of occurrence

I'm trying to look at parquet files and would like to show the number of distinct value of a column and the number of rows it is found in.
The SQL equivalent is:
select distinct(last_name), count(*) from optimization.opt_res group by (last_name)

In scala-spark (displays them separately):
val dataFrame = sparkSession.read.parquet(fname)
dataFrame.show(truncate = false)
val disID = dataFrame.select("last_name").distinct()
disID.show(false)
val disCount = disID.count

I want it to show
+-----------+-------+
| last_name | count |
+-----------+-------+
| Alfred    |   202 |
| James     |  1020 |
+-----------+-------+

A:

dataframe.groupBy($"last_name").agg(count("*"))
or
dataframe.groupBy($"last_name").count
The concept is the same as SQL, but the syntax can be a bit tricky until you get used to it.


in families as indicated by an intraclass correlation coefficient (r(i)) of 0.31 (P = 0.03). FQ, adjusted for age and gender, was also a familial trait for the two days immediately preceding diet (r(i) = 0.32, P < 0.01). The familial effect on 24-h RQ, adjusted for age, gender, and 24-h energy balance, remained after adjustment for the FQ of the two days preceding diet (r(i) = 0.27, P < 0.05) and was reduced but not abolished after further adjustment for fasting plasma insulin plus free fatty acids (r(i) = 0.24, P < 0.09). By a correlation analysis aimed at separating familial and individual nonfamilial factors influencing both 24-h RQ and FQ, we found a great but insignificant familial (etaF = 0.49, P < 0.18) and a somewhatthere’s a quickie montage of the season and Tim Gunn says things that only Tim Gunn can get away with like, “You all have personalities to beat the band!” and “You’re 17 rare hot house flowers!” and “22 Skidoo!”

Then they show Tim Gunn cracking up over Kristen’s wooly balls, which will never get old.

Finally, a montage of crying, that conspicuously didn’t include Michael C’s epic crying/hyperventilating/convulsing jag, because some things are just too awkward to re-live.

Now fun and game time is over and the Top 3 need to get back to the studio and go to work.

Mondo considers adding a black evening dress to his mix, but Tim Gunn kinda talks him out of it? (Bad Tim, bad!).

Mondo decides he’s going to be true to himself.

“I’m going to


huh, who knows? She's certainly talented but somehow she seems like a one-note talent to me - I can't imagine her development over time.

Isn't the Fashion Show with Iman starting soon? I don't know if it'll be any good - didn't watch the first season - but I'm sure your recaps could only improve it. Please, pretty please?

About the outcome of this season of Project Runway, I can agree that it was close to this point: If you compare Gretchen's strongest looks with Mondo's weakest ones then it's a contest. But Gretchen had a lot of crap in that show, most notably the granny panties. The shiny green leather that didn't make any sense with the rest of her stuff was pretty much ass, too. Her best was   num: { type: GraphQLSafeInt },
        },
        resolve: (_root, args) => args.num + 1,
      },
      dec: {
        type: GraphQLSafeInt,
        args: {
          num: { type: GraphQLSafeInt },
        },
        resolve: (_root, args) => args.num - 1,
      },
      valueOf: {
        type: GraphQLSafeInt,
        resolve: (_root)


Q:

Singleton implementation in Go

I have a struct:
type cache struct {
    cap     int
    ttl     time.Duration
    items   map[interface{}]*entry
    heap    *ttlHeap
    lock    sync.RWMutex
    NoReset bool
}

Interface implemented by it:
type Cache interface {
    Set(key, value interface{}) bool
    Get(key interface{}) (interface{}, bool)
    Keys() []interface{}
    Len() int
    Cap() int
    Purge()
    Del(key interface{}) bool
}

And function returning singleton:
func Singleton() (cache *Cache) {
    if singleton != nil {
        return &singleton
   likely to have a minority Parliament, and in that Parliament, the most powerful and effective MPs are the ones that are good at co-operation,” she told KTW.

May visited the city on Monday night, speaking to a packed crowd of supporters at St. Andrews on the Square as part of her national Community Matters tour — an effort to gauge voters’ priorities and concerns in the run-up to the election campaign.

Monday’s forum drew questions such as whether the proportional representation debate was over, enshrining the environment in the Canadian Bill of Rights, how government can support people transitioning out of heavy industries and how to work with First Nations hereditary chiefs.

In response, May said the Greens won’t drop the proportional representation issue and that she would also like to


        jQuery("#lp-slider").Link('lower').to(jQuery('#kwh'));
                </script>

I bound it to an input field. It's working good when the first value is 10.000. But when the first value is below 10.000 I get weird decimals after the comma like "13099.99997" even with decimals=0.
How can I make sure that really only 100s are outputted when I set the way like above in the code?
Thanks in advance for any help!
getimo

A:

Setting the format option on the slider affects the .val() readout. You can use the same formatter on the .Link(), like so:
jQuery("#lp-slider").Link('lower').to(jQuery('#kwh'), null, wNumb({
    decimals: 0
}));

Working jsFiddle.
Edit in response to comment:
You've got yourself a tricky bug there! On line 77, you= -41.8 - -36.8. Let a = -66.3 + 66. What is the biggest value in -3, n, 2/5, a?
2/5
Let g = 13 - 13.3. Suppose -4*h + 4*x = -0*x + 4, 9 = -3*x. Let z = -2.08 - -0.08. Which is the fourth biggest value?  (a) h  (b) 3/2  (c) g  (d) z
a
Suppose -51*x + 38*x - 26 = 0. Let c be ((-39)/12 - -3)*2. Let f = 3 + -2.9. What is the biggest value in f, x, c?
f
Suppose 600 = -23*n + 27*n. Let b be 135/n - 6/(-10). Let u = 16 + -19. What is the second smallest value in 2, u, b, -4?
u
Let v = 0.3673 - 1.3673. What is the fifth smallest value in


that then this probably won’t apply to you but if you are a hardcore gamer who likes to dive deep into games then space considerations are very real. Its not just what you need now but also what you will need in the future.

#4. Be Ready to Play Long Games

Maybe you are a gamer who is used to playing very long games but I’m not. CCGs have been my bread and butter for years and I’ve usually hated extremely long games. This sort of ties into losing a lot. Stomaching quick loses is one thing but it gets old when you play 90 minute games that you were never going to win. I will give the game designers a lot of credit for keeping my interest in the             "check_existing",
                           true,
                           "Check Existing",
                           "Check and warn on overwriting existing files");
    RNA_def_property_flag(prop, PROP_HIDDEN | PROP_SKIP_SAVE);
  }

  prop = RNA_def_boolean(
      ot->srna, "filter_blender", (filter & FILE_TYPE_BLENDER) != 0, "Filter


| PROP_SKIP_SAVE);
  prop = RNA_def_boolean(
      ot->srna, "filter_folder", (filter & FILE_TYPE_FOLDER) != 0, "Filter folders", "");
  RNA_def_property_flag(prop, PROP_HIDDEN | PROP_SKIP_SAVE);
  prop = RNA_def_boolean(
      ot->srna, "filter_blenlib", (filter & FILE_TYPE_BLENDERLIB) != 0, "Filter Blender IDs", "");
  RNA_def_property_flag(prop, PROP_HIDDEN | PROP_SKIP_SAVE);

  prop = RNA_def_int(
      ot->srna,
      "filemode",
      type,
      FILE_LOADLIB,
      FILE_SPECIAL,
      "File Browser Mode",
      "The setting for the file browser mode to load a .blend file, a library or a special file",
      FILE_LOADLIB,
      FILE_SPECIAL);
the Silver Thread or Helpline services, and by the volunteers themselves.
The project also provided volunteers the opportunity to compare the approaches of the two Organizations in delivering the service, to share ideas and solicitations of new effective ways to improve the listening service.
Were included in the project, four weeks stays of six AUSER volunteers in Ireland, and six Third Age volunteers in Italy, in order to contribute to local projects, to participate in activities, cultural events, discussions and interactions with all local volunteers, and some Filo d’Argento National managers in Rome.
These two mobility experiences, which took place in 2011, European Year of Volunteering, were video recorded, volunteers also took care of a large photographic reportage. During the final part of the project, all AUSER Associations, in Le Marche


cover any ensuing damages which may occur. Our warranty covers both workmanship and direct ensuing damages, should a leak occur, providing our customers peace of mind that we stand behind our work.When selecting a roofing professional, be sure to hire a licensed roofing contractor.

theory, I would say that anyone tempted to use
Ackerman set theory would likely prefer the Levy theory, because
the form of reflection is more robust. Furthermore, the strength
of the Levy theory fits right into the large cardinal hierarchy,
equiconsistent with the assertion Ord is Mahlo, which is
strictly weaker than a Mahlo cardinal.
If one drops the assertion that $\delta$ is inaccessible, then one
gets ZFC+$V_\delta\prec V$, which is equiconsistent with ZFC. This
weaker theory is strengthened by the Feferman theory, which
asserts a proper class tower of such $\delta$, essentially
asserting that the entire set-theoretic universe is the union of
an endless transfinite elementary chain $V_{\delta_0}\prec
V_{\delta_1}\prec\cdots V$. This theory is also equiconsistent
with ZFC, but if one wants the $\delta$ to be inaccessible, then
one gets a large cardinal strength still below a Mahlo cardinal.
Because the Feferman theory


/* -*- c++ -*- */
/*
 * Copyright 2008,2010,2012 Free Software Foundation, Inc.
 *
 * This file is part of GNU Radio
 *
 * GNU Radio is free software; you can redistribute it and/or modify
 * it under the terms of the GNU General Public License as published by
 * the Free Software Foundation; either version 3, or (at your option)
 * any later version.
 *
 * GNU Radio is distributed in the hope that it will be useful,
 * but WITHOUT ANY WARRANTY; without even the implied warranty of
 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 * GNU General Public License for more details.
 *
 * You should have received a copy of the GNU General Public License
 * along with GNU Radio; seea tag with this key is detected, the shift register is reset (when this is set, count is ignored!)
       */
      static sptr make(int mask, int seed, int len, int count=0, int bits_per_byte=1, const std::string &reset_tag_key="");

      virtual int mask() const = 0;
      virtual int seed() const = 0;
      virtual int len() const = 0;
      virtual int count() const = 0;
      virtual int bits_per_byte() = 0;
    };

} /* namespace baz */
} /* namespace gr */

#endif /* INCLUDED_BAZ_ADDITIVE_SCRAMBLER_BB_H */


about very limited production specialty items, but any real production automobile would have to be built to the safety standards in effect for the year of manufacture. Perhaps given that these are origional parts made for cars certified years ago, a good lawyer with the right connections may be able to get them grandfathered into the old standards. That would be fine for the manufacturer but less so for the vehicle occupants.

Where I live, solar recharging can be quite practical, but without a range of 60 to 100 miles, at freeway speeds, with A/C running in 110+ degree temperatures and no shade, it still wouldn't be useful for me. For the time being, a tank of liquid fuel is still the only practical way to carry the necessarysame value as AutoOrderID, just a unique value.
CREATE TABLE order_sequence (
  seq INT PRIMARY KEY AUTO_INCREMENT
);

CREATE TRIGGER order_master_BINS BEFORE INSERT ON order_master
FOR EACH ROW
BEGIN
  INSERT INTO order_sequence VALUES (0);
  SET NEW.OrderID = CONCAT('ORD', LAST_INSERT_ID());
END

An SQLfiddle to test the alternate solution with.