INR sampling point \> 1 km, destination accessible by bus, distance to the closest bus stop ≤0.25 km and patient age \< 80 years30 km/h (average speed based on timetables)Total3961

GIS based network analysis {#Sec7}
--------------------------

From a patient's perspective, the effort and cost to reach an anticoagulation clinic or laboratory are dependent on the accessibility of the services used. The geographical accessibility and availability of services, commonly called spatial accessibility \[[@CR24]--[@CR26]\], is affected by the locations of destinations (supply) and starting points (demand) as well as the performance of the transportation system \[[@CR27]\].

Accessibility to healthcare services is usually measured by distance, travel time, or monetary costs; and for large areas, this can be done most easily with GIS (geographic information system) methods using either vector- or raster-based analysis \[[@CR28]\]. The use of vector-based network analysis has increasedIn the alternative DOAC scenario, applying the drug distributor's pricing, the total cost decreases 13.6%. Table 8Cost change in the scenario: shift from warfarin to DOAC (2018 prices)Annual costs in EUR (share % from total costs)Drug retail prices (excl. VAT)Distributor's drug pricesBaselineScenarioChangeBaselineScenarioChangeCosts of INR monitoring:2,974,840 (59.8)343,500 (6.7)−88.5%2,881,800 (62.9)326,180 (8.2)−88.7% INR measurements and medication (*N* = 4560)2,781,820 (56.0)2,688,780 (58.7) Time costs of INR monitoring (*N* = 4560)193,020 (3.8)193,020 (4.2) Patients unable to switch to DOAC (*N* = 296)270,230 (5.3)264,190 (6.7) Patients not switching to DOAC (\<  5 INR M. 2017, *N* = 553)73,270 (1.4)61,990 (1.5)Travel costs:815,090 (16.4)97,840 (1.9)−88.0%815,090 (17.8)97,840 (2.5)−88.0% Direct travel costs (*N* = 3961)715,990 (14.4)715,990 (15.6) Travel time costs (*N* = 3961)99,100 (2.0)99,100 (2.2) Patients continuing warfarin (*N* = 772)97,840 (1.9)97,840 (2.5)Cost of DOAC therapy:1,181,850 (23.8)4,661,180 (91.4)294.4%883,970 (19.3)3,531,580 (89.3)299.5% Patients using DOAC (*N* = 1239)1,181,850 (23.8)1,181,850 (23.2)883,970 (19.3)883,970 (22.3) Patients switching from warfarin to DOAC (*N* = 3711)3,479,330 (68.2)2,647,610 (67.0)Total cost of anticoagulation management:4,971,780


two BnC24 genes encode basic 24 kDa proteins, which are highly hydrophilic and rich in alanine, lysine and arginine. The nucleotide and deduced amino acid sequences of these clones do not show any homology with other previously described cold-induced plants genes. However they have strong homology with a recently discovered human tumour gene, bbcl (breast basic conserved), which seems to be highly conserved in eukaryotes.Presidential election: can Sarkozy win back the popular vote?

President Sarkozy is back on the campaign trail and has returned to France's industrial north, where swaying disgruntled factory workers may be a tall order. After the interior minister announced his plan to ban praying in the street, we consider the religious and political conundrum facing this secular state. Finally, we dip into the magical world of Oksa Pollock.

Born in Belgium, raised in Italy and now resident in France, he holds a degree in Japanese. He previously worked for CNN International. At FRANCE 24, he presents the news on Friday, Saturday and Sunday evenings and also the show France in Focus.


and 62-M-1 to 62-M-N, M beamforming sections 64-1 to 64-M, M direction-of-arrival (DOA) estimating sections 63-1 to 63-M, a Rake combining section 65 and a data determining section 66, where N and M are integers. Those components will be elaborated below.
In the conventional base station apparatus, signals which are to be received by the N antennae 60-1 to 60-N are subjected to radio processing (downconversion, A/D conversion, etc.) by the N reception sections 61-1-1 to 61-N which are provided in association with the antennae 60-1 to 60-N, and are then input to the N×M despreading sections 62-1-1 to 62-1-N, . . . , and 62-M-1 to 62-M-N.
The despreading sections 62-1-1 to 62-1-N, . . . , and 62-M-1 to 62-M-N perform a despreading process on signals which respectivelyBlue Stahli – “Ready Aim Fire”

Auditory alchemist Blue Stahli sends us premonitions of an impending sonic assault bearing down on the unsuspecting public. Your skull will shake and your speakers will tremble as the next chapter of The Devil is revealed right before our eyes.

Preorder The Devil Chapter 02 on iTunes or the FiXT Store and receieve and instant download of the new single “Ready Aim Fire.” You can also stream the single for free on Spotify (starting 07/16) or watch the lyric video on YouTube now!


to induce DNA damage and genomic instability [@pbio.1001856-Sheu1].

Patients with FA are defective in a pathway required for the repair of DNA ICLs, causing elevated genome instability and cancer risk [@pbio.1001856-Kim1]--[@pbio.1001856-Deans1]. The FA pathway regulates the mono-ubiquitination of two related proteins, FANCD2 and FANCI, that in turn coordinate the recruitment of several nucleases required to unhook the ICL, resulting in an unhooked cross-linked nucleotide on one DNA molecule and a DSB on the other. Translesion synthesis (TLS) allows bypass of the unhooked cross-linked nucleotide, necessary for generating a template suitable for HR-dependent DSB repair. Nucleotide excision repair (NER) then removes the nucleotide with the cross-linked adduct. Initiation of the FA pathway requires the multifunctional FANCM--FAAP24 heterodimer, which recognises ICLs, recruits the FA core complex, and contributes to both stabilisationNucleofected cells were added to 10 ml of RPMI containing 100 nM 4-OH-Tamoxifen and after growth for 24 h plated into 96-well plates at 0.5/1/1.5 cells per plate. After 7--8 d, subclones were picked and replated under selection for further analyses.

Purification of ATM in DT40 Cells {#s4e}
---------------------------------

A total of 1 l of WT and HFSC-ATM cells were grown in petri dishes to a maximum confluency of 1×10^6^ cells/ml, harvested, resuspended in 0.5 l of the conditioned media, and irradiated with 10 Gy. After 1 h recovery at 39°C, they were washed (1× PBS; ice-cold) and resuspended in 2 ml Lysis Buffer \[50 mM Tris-HCl, pH 7.5; 150 mM NaCl; 0.5% NP-40; 1× Protease inhibitors (Roche tablet); 1× phosphatase inhibitors (SIGMA)\] at 4°C for 30 min. Chromatin was solubilised


h in the dark. Images were acquired using a wide field Olympus Biosystem microscope and the Velocity software.

Antibodies {#s4o}
----------

The antibody against chicken Atm was raised by Pocono Rabbit Farm (Canada); ATM human antibody, SNF2H, BAZ1A, RIF1, and FANCI were all purchased from Bethyl Laboratories; and the RSF1 monoclonal antibody, phospho-ATM-S1981, and γ-H2AX were from Millipore and NBS1 antibody from Novus. Human ATR and FANCD2 antibody were from Santa Cruz. Histone H3.1, Actin, and BAZ1B were purchased by Abcam. CENPA antibody was a kind gift from Dr. Kevin Sullivan. MHF1 and MHF2 were a kind gift from Dr. Weidong Wang (Baltimore, Maryland), and the FANCD2 antibody was a kind gift from Professor Minoru Takata (Kyoto, Japan).

Clonogenic Survival Assay Using DT40 Cells {#s4p}
------------------------------------------

Methyl cellulose medium was poured into 10 cmhomologous recombination

ICL

:   interstrand cross-links

IR

:   ionizing radiation

IRIF

:   IR induced foci

NHEJ

:   nonhomologous end joining

ssDNA

:   single-stranded DNA

TLS

:   translesion synthesis

[^1]: The authors have declared that no competing interests exist.

[^2]: The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: NFL FP. Performed the experiments: FP. Analyzed the data: NFL FP. Wrote the paper: NFL FP.


 - -14. What is the nearest to -2 in s, -5, 3?
s
Let r be (16/10)/4 + -1. Suppose 3*n = -4*w + 12 - 1, 0 = 4*n - 3*w - 48. Let f = n - 9. What is the nearest to f in 0.5, 4, r?
0.5
Let v = -2702 + 2701.6. Let f be 0 + 1/(-3)*1. Let p be (-4)/6 + 0 + 1. What is the closest to 1 in p, f, v?
p
Suppose -11*d + 66 = -10*d. Let h = 200/3 - d. What is the nearest to 0 in 0, h, -1?
0
Let p = -749 - -747. Let n = -3 + 3. Which is the closest to p?  (a) -1  (b) 1  (c) n
a
Let k = 0.029closest to -1 in 0.3, -5/4, c?
-5/4
Let d = -19 - 1. Let t = d + 23. Let l = 32.5 - 33. What is the closest to t in -3, l, 0.5?
0.5
Suppose -2*a + 2 = 0, 5*a = 4*p - 8*p + 9. What is the closest to 1/17 in p, 3, -5?
p
Let x be 2 - (2 - -3 - 0). What is the nearest to x in 0.4, 1/9, -1/3, 5?
-1/3
Let r = 2728 + -2728.2. Let q = -0.2 - -0.1. What is the nearest to q in -4, 2/9, r?
r
Suppose -2 = 4*a - 5*a. Let o be -2 + 1 - -4 - 1166/374. Let y = 15 + -46/3. What is the nearest to a in o, 0.3, y?
0.3
Let


= u + 3. Let h be t(0). Suppose 3*c + s = -4 + 1, -4*c + 3*s + 9 = 0. Let r = -11 + 14. What is the nearest to h in r, c, -1/5?
r
Let u = 131.9 + -132. What is the closest to -1 in u, 13, 1?
u
Suppose -4*l - 14 = a, -2*a = -0*a - 4. Let d be 0*(-4)/8 - 0. Let z be d + 1 - 1/1. What is the closest to 2 in z, -2, l?
z
Let x = -796.02 + 796. What is the nearest to 0.1 in -21, 1, 2, x?
x
Let c = -50 - -50.066. Let d = -0.036 + c. Let z = 3 + -3.2. What is the closest to d inTo reinforce the bag, they used an elastic tie exoskeleton, showing 3D printing’s versatility. Their 3D printed handbags are still available today on their website for a price of between €398 and €568.

10. Bits Tailor Accessories

Bits Tailor is a French startup that offers customizable fashion accessories from bow ties to shoe decorations. These accessories are manufactured in part thanks to 3D printing: the perfect tool to bring your creations to life.

Using an FDM desktop printer, they are able to 3D model their unique pieces, shaping and designing them until they are left with the best result. After modeling, they then print the piece in metal in order to have a high quality, finite piece. You can choose from their pre-made models and customize their color, pattern, and material,


Laura Thapthimkuna has created an unusual dress that combines her passion for space and 3D printing. Using the stereolithography process and resin as her printing material of choice, she managed to create a garment that depicts the black holes of space, giving it a unique and standout look. After printing, Thampthimkuna painted her piece black to give it the dark look of space.

After the printing process, the stylist tested the structure of her garment several times. She stated her biggest difficulty was finding a medium to distribute its weight due to the dress’ size.

This 3D printed fashion dress is visually stunning.

What do you think of this 3D printed fashion? let us know in a comment below or on our Facebook and Twitter pages. Don’t forget to sign up6*f + 7. Suppose 0 = 2*j - 8 - 2. Let a be 4 - 56/60*-6*5. Suppose -2 + a = -j*v. Determine v*g(s) - 7*q(s).
-3*s**2 + s
Let l(w) = -481*w**3 + 91*w. Let u(b) = -32*b**3 + 6*b. Let f be (524/(-393))/(2/9). Calculate f*l(o) + 91*u(o).
-26*o**3
Let b(j) = -15*j**2 - 10*j - 10. Let d(t) = 4 + 0 + 3*t - 1 + 5*t**2. Let s = 36246 + -36249. Calculate s*b(n) - 10*d(n).
-5*n**2
Let w = -99 - -108. Let t(f) = w - 2*f**2 + 0*f**2 + 49*f - 41*f - 2. Let x(s) = s + 1. Give -t(n) + 6*x(n).
2*n**2 - 2*n - 1
Let n(l) = -3*l**3 + 2*l**2 + 4*l - 7. Let i(s) = 8*s**2 - 268*s + 128. Let


Benchmarks (MATLAB, SciPy, Julia, deSolve (R)) (which includes direct benchmarks of Sundials and Hairer's methods as well). For general benchmarks of the algorithms which are mentioned in this post, see the DiffEqBenchmarks.jl repository. All other packages were benchmarked by looking at the same set of problems implemented by modifying the example code from their documentation.

MATLAB's Built-In Methods

Due to its popularity, let's start with MATLAB's built in differential equation solvers. MATLAB's differential equation solver suite was described in a research paper by its creator Lawerance Shampine, and this paper is one of the most highly cited SIAM Scientific Computing publications. Shampine also had a few other papers at this time developing the idea of a "methods for a problem solving environment" or a PSE. The idea is pretty simple:to add discontinuity tracking to their state-dependent delay equation solver. SciPy. SciPy needs a lot of work. But two very simple steps they can take are to wrap Radau and Rodas. Since they already wrap two of Hairer's methods, it can't be that bad. A larger goal would be to expose dense output and add an event handling interface. I would like it if they picked a JiT setup to go along with their offering since that would go a long way, but it's okay if those remain extra tools. R deSolve. Add a Rodas wrapper. Add a higher order explicit RK method. Once again, a way to compile user-functions would be great but is a larger project DifferentialEquations.jl. Implicitly-defined ODEs can use some help since the solvers


other tests it seems that this doesn't adversely effect the behavior on some semi-stiff diffusion-advection problems which may be the reason for these parameter choices, but it's interesting to note that this divergence occurs on pretty much every highly stiff problem. Part of the reason is due to odd defaults. Almost no algorithm uses a time stepping safety factor that's not 0.9, but ARKODE defaults to 0.96 which in tern puts it closer to the error/stability limits. That's just one of many parameter defaults that is odd. In addition, if they implemented the algorithm like they described at this site, then the implicit equations would be prone to divergence when there's stiffness. Shampine noted that an altered form is more stable, and this altered form is used byfor adjoint sensitivities works really well for calculating gradients of PDE-constrained models. Thus even though it's only implemented a portion of the possible addons, what it does it does well so it deserves the Excellent.

Edits: 11/23/2019

There have been a lot of movement in the last year with the Julia DifferentialEquations.jl and the SUNDIALS solvers. This has upped the standards a bit, meaning that if a library only has methods for standard u'=f(u,p,t) forms then it cannot be considered "Good" given the amount of support for specialized ODE forms. From this, a few libraries were bumped down to fair, given they have the standard stuff but none or not many of these special pieces. Also, confirmation that if you write your own C/Fortran code to compile for deSolve was


   <link rel="stylesheet" href="">
    <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.5.1/jquery.min.js"></script>
    <script>
        $(document).ready(function() {
            $('select.unit').change(function() {
                let selectedUnit = $(this).children("option:selected").val();
                console.log(selectedUnit)
                $.ajax({
                    url: "./data.php",
                   enthusiastic said that Charlton Heston was “axiomatic.” He might want that pensée back now. But Stanton is at least emblematic of sad films of action and travel. His face is like the road in the West.

This isn’t incorrect, but it’s still incomplete. In Oney’s profile, the young Sean Penn, who adopted Stanton as his mentor, offers the same sort of faint praise: “Behind that rugged old cowboy face, he’s simultaneously a man, a child, a woman—he just has this full range of emotions I really like. He’s a very impressive soul more than he is a mind, and I find that attractive.” I don’t want to discount the love there. But it’s also possible that Stanton never landed the parts that he deserved because his friends never got


// Copyright Aleksey Gurtovoy 2000-2004
//
// Distributed under the Boost Software License, Version 1.0.
// (See accompanying file LICENSE_1_0.txt or copy at
// http://www.boost.org/LICENSE_1_0.txt)
//

// *Preprocessed* version of the main "bind_fwd.hpp" header
// -- DO NOT modify by hand!

namespace boost { namespace mpl {

template<
      typename F
    >
struct bind0;

template<
      typename F, typename T1
    >
struct bind1;

template<
      typename F, typename T1, typename T2
    >
struct bind2;

template<
      typename F, typename T1, typename T2, typename T3
    >
struct bind3;

template<
      typename F, typename T1, typename T2, typename T3, typename T4
    >
struct bind4;

template<
      typename F,(IWR), the instruction word registers are connected directly to a multiplexer (MPX) and to the input of a plurality of instruction buffer registers (IBR), and the instructions stored in the IWR and IBR are selected by the MPX and applied to a pipeline system. In this branch instruction control system, however, the instructions are not written and read by using a write pointer and a read pointer as a register file configuration, but are written or read by using a shift register configuration. Therefore, the quantity of hardware in this branch instruction control system cannot be less than that needed when using a register file configuration.


as bleak as any prison or asylum, insulted by a drunken and manic brother, oppressed by a stern and occasionally violent father, finding their relief only in wonderful little treks across the Yorkshire moors.

Mrs. Gaskell, possibly the most credulous and most sentimental biographer of the nineteenth century, began the process. She was already a famous novelist, but she reserved her finest fictional touches for her life of Charlotte Brontë. Her sublimely inaccurate portrait was followed by works of various other biographers, who managed to fill their books with material more extravagant than anything to be found in a Brontë novel. One of them had the sisters eating “gypsy fashion” on the moors, while another tried to prove that all their writings were based upon Irish originals.

There was ait is clear that I am a professional published writer. Nothing you have said in your statement has merit to what is being pointed out in this consumer complaint. The fact that you are trying to sayI am writing somewhere as someone else, which is a lie (other than my pen name of Eric Morse). It is all childish game playing to try to divert readers from the true issue. As Speak The Truth said I and not Mr. Fitzgerald. Mr.Fitzgerald has supported me in the past. The thing is you are just being juvanile to put out bulls*** like "he has no support he just manufactures it all himself." It is all bulls*** and lies perpetrated by children.

The facts are clear. Dorine and Aaron had a contract


Total). No he is not a shut down guy, but Pittsburgh clearly thinks highly of him now @ $5.5 million for the next 3 seasons. I trust this Edmonton regime is less likely to screw up the young defensemen they have now than the previous regime was.

Klef should have been in the top 5 for Lady Bing last year – d-men are severely underrepresented in that category historical.

Klef will never be an “elite first pairing d-man” but he has already show to indeed be a first pairing d-man. His offence should continue to spike as the defensive group as a whole is able to transition the puck better and Klef gets even more comfortable on the PP1.

I’d like to see less chaos in his defensive game but itson our soil, and rightfully so. And yet, we have a Congress that explicitly blocks us from even collecting data on how we could potentially reduce gun deaths. How can that be?” He added, “This is a political choice that we make to allow this to happen every few months in America.” More than anything else, Obama used his remarks last night to FORCE the American public to once again have a conversation about guns in America -- a conversation we might not be having as vigorously had the president refrained from speaking.

Will Obama (and others) follow through?

So here’s the question we have: Will Obama follow through? Yes, he pursued gun control after the tragic Newton shootings. And, yes, he continues to speak out forcefully after other shootings.


they’re not safe in church basements, they’re not safe in movie theaters. Enough is enough is enough.” Bernie Sanders added in a statement, “As a nation, we must do everything we can to put an end to this awful epidemic of senseless slaughter. We need a comprehensive approach. We need sensible gun-control legislation.” (A problem for Sanders is headlines like this one: “How the National Rifle Association helped get Bernie Sanders elected.”) On the other hand, Mike Huckabee issued a statement blasting President Obama. “With few facts, Obama is quick to admittedly politicize this tragedy to advance his liberal, anti-gun agenda. For this president to make a political pronouncement is at best premature and at worst ignorantly inflammatory.” But expect this conversation -- or debate -- to continuethe truth on behalf of the families of four dead Americans. Now I did not intend to imply in any way that that work was political. Of course it is not, look at the way they have carried themselves out,” McCarthy said, per NBC’s Alex Moe. “The point I was trying to make and I want to be very clear about this, I wasn’t saying the committee was political, that committee is solely to get the truth out.” More: “What happened with the truth, we found out about a server. This committee's sole purpose is to find truth why four Americans were killed that night.” The problem here: The NRCC, the Republican Party’s House campaign arm, was running this fundraising solicitation: “You’re now a Benghazi Watchdog. Let’s go


mean: 1) That those donors will be loyal to you if you falter in the future, and 2) that you'll win your party's nomination. In fact, we went back through the last three presidential cycles' worth of Q3 reports and noticed that each one's big winner (Rick Perry in 2011, Hillary Clinton in 2007, Mitt Romney in 2007 and Howard Dean in 2003) didn't win their party's nomination.”

Trump on “Meet” this Sunday

Finally, NBC’s Chuck Todd will interview Donald Trump for this Sunday’s “Meet the Press.” Also be sure to put this on your calendar: NBC’s Savannah Guthrie will interview Hillary Clinton as part of a “Today” town hall in New Hampshire.

Click here to sign up for First Read emails. Text FIRST to 622639, to sign up for Firstof the system. For instance, in the case of a wireless terminal, the main processor 100 may become a modem chip such as an Mobile Station Modem (MSM). Each of the boot modules stored in the first flash memories 110 and 210 represents a software module which initializes an operation of a corresponding processor and can actually shift into a main software routine. Further, the loader module represents a software module for moving the remaining main software code portions to a memory area which can be controlled by a controller, when only some necessary modules other than the remaining main software code portions are initialized and operated after booting. The bootloader module represents a software module in which the boot module is combined with the loader module. The


the mission.
Is there a way to figure out which provinces are actually in the success criteria, or do I need to take the trial and error approach?

A:

If I recall correctly, I can't check right now, the "Region Mapmode" shows you in a subcategory whether a North American province is considered Canada or whether it is not, if you hover over the province itself.
Additionally, even though you looked, the mission should be contained somewhere within the "missions.txt" and denote exactly which provinces are needed for it to succeed.

on a reactor's external side faces, not as part of the frame", xCoord, yCoord, zCoord));
	}

	@Override
	public void isGoodForSides() throws MultiblockValidationException {
	}

	@Override
	public void isGoodForTop() throws MultiblockValidationException {
		throw new MultiblockValidationException(String.format("%d, %d, %d - Redstone ports may only be placed on a reactor's external side faces, not the top", xCoord, yCoord, zCoord));
	}

	@Override
	public void isGoodForBottom() throws MultiblockValidationException {
		throw new MultiblockValidationException(String.format("%d, %d, %d - Redstone ports may only be placed on a reactor's external side faces, not the bottom", xCoord, yCoord, zCoord));
	}

	@Override
	public void isGoodForInterior() throws MultiblockValidationException {
		throw new MultiblockValidationException(String.format("%d, %d, %d - Redstone ports may not be placed in a reactor's interior", xCoord, yCoord, zCoord));
	}

	@Override
	public void onMachineAssembled(MultiblockControllerBase controller) {
		super.onMachineAssembled(controller);
		this.sendRedstoneUpdate();
	}

	@Override
	public void onMachineBroken() {
		super.onMachineBroken();
		this.sendRedstoneUpdate();
	}

	@Override
	public void onMachineActivated() {
		this.sendRedstoneUpdate();
	}

	@Override
	public void onMachineDeactivated() {
		this.sendRedstoneUpdate();
	}

	// IBeefGuiEntity
	@SideOnly(Side.CLIENT)
	@Override
	public Object getGuiElement(InventoryPlayer inventoryPlayer) {
		return new GuiReactorRedstonePort(new ContainerBasic(), this);
	}

	@Override
	public Object getContainer(InventoryPlayer inventoryPlayer) {
		return new ContainerBasic();
	}

	public static


die area results in fewer die per wafer, resulting in a more expensive die cost.
Fifth, in epitaxial processes, the epitaxial layer thickness must be chosen to integrate the highest voltage device needed on a given chip. As explained previously, higher voltage devices requires deeper, less area-efficient isolation diffusions. These thick, wide-isolation diffusions are then required even in the lower voltage sections of the chip, wasting even more area. So in conventional processes, the highest voltage device sets the area efficiency of all isolated regions.
Sixth, many IC processes do not have the capability to integrate a voltage independent capacitor like poly-to-poly, poly-to-metal, or metal to poly, nor do they contain a high sheet resistance material for high value resistors.
FIGS. 1–6 illustrate some of the problems associated with various priorparasitic NPN transistors elsewhere in the IC chip (e.g. comprising N well 132, P substrate 130 and any other N+ region located within P substrate 130), and these NPNs can combine with the PNP in N well 132 to produce a latch-up condition (parasitic thyristor action).
In digital applications these problems may not be significant. Typically the PN junctions do not become forward-biased. The wells are heavily doped and there is no particular concern with having high breakdown voltages or a flat output current characteristic when the transistor is turned on.
PMOS 101 and NMOS 102 work reasonably well in a circuit of the kind shown in FIG. 1B, where the source and body of PMOS 101 are both tied to Vcc, and the source and body of NMOS 102


the same parasitic PNP transistor (dashed lines) described before for PMOS 101.
In NMOS 104, P well 134 has been limited to enclose only the N+ source region 160 and the P+ body contact region 162, and an N well 158 has been formed adjacent to and enclosing N+ drain region 164. Gate 166 overlaps the field oxide region 152 and onto thin gate oxide (active region) overlapping the surface channel formed by the N sidewall spacer of N+ 160 acting as source, Pwell 134 acting as body, and Nwell 158 acting as drain of a high voltage N-channel MOSFET 104. In NMOS 104, the current flows from the N+ source region 160 and through P well 134 (the channel region) and N well 158 to N+ drain regionused, the wasted area lost to high voltage isolation (and related design-rule spacing) cannot be reclaimed without re-engineering the entire process and affecting every component in the IC. Such a process is not modular, since the addition or removal of one component adversely affects all the other integrated devices.
Accordingly, there is a clear need for a technology that would permit the fabrication of an arbitrary collection of optimized transistors or other devices, closely packed together in a single semiconductor wafer, fully isolated, in a modular, non-interacting fashion.


your question asked: you can use a partial index like:
CREATE INDEX foo ON tbl (tbl_id)
WHERE bitfield & '0010' = '0010';

& being the bitwise AND operator.
tbl_id being the PK column. (The actual index column hardly matters here.)
In combination with a matching query:
SELECT *
FROM   tbl
WHERE  bitfield & '0010' = '0010';

But your question probably does not reflect your complete situation. There may be better options.

from $(a, b - 1)$ to $(a, b)$); some number $j_1 = j_1 (a, b)$ of incoming horizontal edges (from $(a - 1, b)$ to $(a, b)$); $i_2 = i_2 (a, b)$ outgoing vertical edges (from $(a, b)$ to $(a, b + 1)$); and $j_2 = j_2 (a, b)$ outgoing horizontal edges (from $(a, b)$ to $(a + 1, b)$). We refer to the right side of Figure \[vertexedgespaths\] for an example (where there we allow multiple arrows to occupy edges). The quadruple $\big(i_1, j_1; i_2, j_2 \big)$ is called the *arrow configuration* associated with the vertex $(a, b) \in \mathcal{D}$. Observe that the same number of arrows enter and exit each vertex, that is, $i_1 + j_1 = i_2 + j_2$; this is sometimes referred to as


lattice, it actually suffices to only track one. Indeed, the identities according to which the dynamical parameters $\lambda$ and $v$ change across the lattice are determined by the directed path ensemble (or, equivalently, by the configuration of arrows entering and exiting each vertex), which can be encoded by a single height function on the dual lattice. Thus , as well as its more general fused versions described below, can be viewed as an SOS model in the usual sense.

The $S_{1; 1}^{\text{ell}}$ weights above are in fact the $J = 1 = \Lambda$ special cases of the *stochasticized elliptic fused weights* $S_{J; \Lambda}$ given by and below, which are (both vertically and horizontally) fused versions of the $S_{1; 1}^{\text{ell}}$ weights. We will not describe them here since their form,y \big) = S_{1; 1}^{\text{\emph{ell}}} \big( i_1, j_1; i_2, j_2 \operatorname{\boldsymbol{|}}\lambda, v; x, y \big)$.

Furthermore, for any fixed $i_1, j_1, k_1, i_3, j_3, k_3 \in \{ 0, 1 \}$ and $\lambda, v, x, y, z \in \mathbb{C}$, we have that

\_[i\_2, j\_2, k\_2 { 0, 1 }]{} & S ( i\_1, j\_1; i\_2, j\_2 | ; v - 2 k\_1; x, y ) S ( k\_1, j\_2; k\_2, j\_3 | + 2 (2i\_2 - 1); v; x, z )\
& S ( k\_2, i\_2; k\_3, i\_3 | ; v - 2 j\_3; y, z )\
= \_[i\_2, j\_2, k\_2 { 0, 1 } ]{} & S ( k\_1, i\_1; k\_2, i\_2 | + 2 (2j\_1 - 1); v; y, z ) S ( k\_2, j\_1; k\_3, j\_2 | ; v -


these fused weights are stochastic and satisfy a dynamical variant of the Yang-Baxter equation. The $L = M = T = 1$ case of that result states the following.

\[dynamicalrankstochasticlm1\]

For any integers $a, b \in [0, n]$ and complex numbers $x, y, v \in \mathbb{C}$, we have that

\_[0 c, d n]{} S ( a, b, c, d | x, y; v ) = 1,

where we abbreviated $S \big( a, b, c, d \operatorname{\boldsymbol{|}}x, y; v \big) = S_{1; 1}^{\text{\emph{col}}} \big( a, b, c, d \operatorname{\boldsymbol{|}}x, y; v \big)$.

Furthermore, for any fixed complex numbers $x, y, z, v$ and integers $i_1, j_1, k_1, i_3, j_3, k_3 \in [0, n]$, we have that

\_[0 i\_2, j\_2, k\_2 n]{} & S ( i\_1, j\_1; i\_2, j\_2 | x, y; q\^[1 - ***1***\_[k\_1 =below = 25\][$k$]{};

(-.1, .92) – (-1, .92); (-.1, 1) – (-1, 1) node\[scale = .8, left = 0\][$k + i_2 + j_2$]{}; (-.1, 1.08) – (-1, 1.08);

(.92, .1) arc(5:85:.92); (1, .1) arc(5:85:1) node\[scale = .8, right = 40, below = 5\][$k + j_2$]{}; (1.08, .1) arc(5:85:1.08);

(0, 0) circle \[radius = .1\] node\[scale = .8, below = 7, left = 1\][$u$]{}; (0, 1) circle \[radius = .1\] node\[scale = .8, above = 8, left = 0\][$u_2$]{}; (1, 0) circle \[radius = .1\] node\[scale = .8, below = 7, right = 1\][$u_1$]{};

(9.1, 1) – (10, 1); (9, .1) – (9, .9);

(9, 1.1) – (9, 2); (8.1, 1) – (8.9, 1); (7, 1) – (7.9, 1);

(9, -1) – (9, -.1);

(10, -.05) – (9.1, -.05) node\[scale = .8, above = 1, right


circle \[radius = .1\]; (0, 2) circle \[radius = .1\];

(5, 1) circle \[radius = .1\]; (1, 2) circle \[radius = .1\];

(2, 2) circle \[radius = .1\]; (3, 2) circle \[radius = .1\];

(4, 2) circle \[radius = .1\];

(9, -1) – (9, -.1);

(10, -1) – (10, -.1); (10, .1) – (10, .9); (10, 1.1) – (10, 1.9);

(11, .1) – (11, .9);

(12, 1.1) – (12, 1.9);

(13, -1) – (13, -.1); (13, .1) – (13, .4);

(9.1, 0) – (9.9, 0);

(10.1, 0) – (10.9, 0);

(11.1, 1) – (11.9, 1);

(13.95, -.9) – (13.95, -.1); (14.05, -.9) – (14.05, -.1);

(13, .58) arc(265:185:.42); (13, .5) arc(265:185:.5); (13, .42) arc(265:185:.58);

(13.95, .1) arc(50:88:1.45); (14.05, .1) arc(47:89:1.45);

(12.42, 1.1) arc(2:40:1.42); (12.5, 1.1) arc(2:43:1.45); (12.58, 1.1) arc(2:46:1.48);

(11.9, 1.91) – (11.1, 1.91); (11.9, 1.97) – (11.1, 1.97); (11.9, 2.03) – (11.1, 2.03);(-1, 1) circle \[radius=.03\] node \[scale = .5, black, below = 2, right = 0\] [$x$]{}; (-2, 2) circle \[radius=.03\] node \[scale = .5, black, above = 0\] [$z$]{}; (-1, 2) circle \[radius=.03\] node \[scale = .5, black, above = 0\] [$y$]{}; (.925, .85) circle\[radius=0\] node\[scale = 1.2\][$=$]{}; (-3.75, .75) circle \[radius=0\] node \[scale = 1.2, black, left = 1\] [$\displaystyle\sum_{c}$]{}; (2.75, 0) – (3.75, 1) – (3.75, 2) – (2.75, 1) – (2.75, 0); (2.75, 0) – (3.75, 1) – (4.75, 1) – (3.75, 0) – (2.75, 0); (3.75, 1) – (4.75, 1); (3.75, 2) – (4.75, 2); (4.75, 1) – (4.75, 2); (2.75, 0) circle \[radius=.03\] node \[scale = .5, black, below = 0\] [$a$]{}; (3.75, 0) circle \[radius=.03\] node \[scale = .5, black, left =


that the plaquette weights here become vertex weights. Now, the weights $w$ and $\chi$ here will be the $w$ and $\chi_s$ from , respectively.

We claim that $w$ is stochasticizable with respect to $\chi_s$. The first condition there was verified in , and the second is a consequence of the vertex form of the Yang-Baxter equation, given by . To verify the third condition, we must explain how to attach two shaded vertices to each vertex $u \in \mathcal{D}$.

This was essentially done in . Specifically, we begin with a stochasticization curve to the right of $\mathcal{D}$ that starts with $k$ arrows and collects any arrow outputted by $\mathcal{D}$, as in the top-left diagram of . We then move the stochasticization curve through $\mathcal{D}$, one vertex at a time usingvertex in our domain, the Yang-Baxter equation will typically no longer hold for the stochasticized weights. Imposing the consistency condition is one way of ensuring that the Yang-Baxter equation is preserved; see below.

In , the attachment of a pair of shaded vertices resulted in a dynamical parameter $v(u)$ (or $k(u)$) associated with each vertex $u$ in our domain. The consistency condition then essentially explains how the dynamical parameter changes between vertices, according to the identities (see also ). A similar phenomenon will appear in later examples of stochasticization.

Now we can define the stochasticized plaquette weights analogously to .

\[wschiweights\]

Suppose that $w$ is stochasticizable with respect to $\chi$ in the sense of Definition \[wchiconditions\]. Let $P = (v_1, v_2, v_3, v_4)$ be a plaquette and denote $\mathcal{F} (v_1) = a$,


– (2, 2); (1, 0) circle \[radius=.03\] node \[scale = .8, black, left = 1\] ; (0, 0) circle \[radius=.03\] node \[scale = .8, black, below = 0\] ; (0, 1) circle \[radius=.03\] node \[scale = .8, black, above = 0\] ; (.92, .92) rectangle (1.08, 1.08) node \[scale = .8, black, right = 0\] ; (1.92, .92) rectangle (2.08, 1.08) node \[scale = .8, black, below = 2\] ; (.92, 1.92) rectangle (1.08, 2.08) node \[scale = .8, black, right = 1\] ; (1.92, 1.92) rectangle (2.08, 2.08) node \[scale = .8, black, above = 0\] ;

;

We will occasionally refer to the quantity $\frac{ S_P (a, b, c, d)}{w(a, b, c, d)}$ as a *stochastic correction*.

Properties of Stochasticization {#PropertiesWeights}
-------------------------------

In this section we establish various properties of the4.7) circle \[radius=.03\] node \[scale = .8, black, left = 0\] [$a$]{}; (12.3, 5.7) circle \[radius=.03\] node \[scale = .8, black, left = 0\] [$d$]{}; (13, 6.4) circle \[radius=.03\] node \[scale = .8, black, above = 2\] [$z$]{}; (14, 6.4) circle \[radius=.03\] node \[scale = .8, black, above = 2\] [$y$]{}; (14.7, 4.7) circle \[radius=.03\] node \[scale = .8, black, below = 2\] [$v$]{}; (14.7, 5.7) circle \[radius=.03\] node \[scale = .8, black, above = 2\] [$x$]{};

(13, 5) circle \[radius=.03\] node \[scale = .8, black, above = 7, right = 0\] [$c'$]{}; (14, 5) circle \[radius=.03\] node \[scale = .8, black, above = 5, right = 0\] [$f'$]{}; (13.7, 5.7) circle \[radius=.03\] node \[scale = .8, black, above = 0\] [$g'$]{};

(14.08, 6.32) – (13.92, 6.32) – (13.92, 6.48)


circle \[radius=.03\] node \[scale = .8, black, left = 0\] [$a$]{}; (12.3, 1.7) circle \[radius=.03\] node \[scale = .8, black, left = 0\] [$d$]{}; (13, 2.4) circle \[radius=.03\] node \[scale = .8, black, above = 2\] [$z$]{}; (14, 2.4) circle \[radius=.03\] node \[scale = .8, black, above = 2\] [$y$]{}; (14.7, .7) circle \[radius=.03\] node \[scale = .8, black, below = 2\] [$v$]{}; (14.7, 1.7) circle \[radius=.03\] node \[scale = .8, black, above = 2\] [$x$]{};

(13, 1) circle \[radius=.03\] node \[scale = .8, black, above = 7, right = 0\] [$c''$]{}; (14, 1.7) circle \[radius=.03\] node \[scale = .8, black, above = 3, right = 2\] [$f''$]{}; (12.9, 1.6) circle \[radius=.03\] node \[scale = .8, black, above = 6, right = 0\] [$g''$]{};

(14.08, 2.32) – (13.92, 2.32) –of , where there the dynamical parameter $v(u)$ is drawn in the lower-right face containing $u$.

The stochasticity and dynamical Yang-Baxter in this setting is given by the following theorem, which takes into account both dynamical parameters $v$ and $\lambda$.

\[dynamicalequationellipticstochastic\]

Adopt the notation of Theorem \[ellipticfusedstochastic\]. For any fixed $\Lambda, x, y, \lambda, v  \in \mathbb{C}$; $J \in \mathbb{Z}_{> 0}$; and $i_1, j_1 \in \mathbb{Z}_{\ge 0}$, we have that $\sum_{i_2, j_2 \in \mathbb{Z}_{\ge 0}} S_{J; \Lambda} \big( i_1, j_1; i_2, j_2 \operatorname{\boldsymbol{|}}\lambda, v; x, y \big) = 1$.

Furthermore, for any fixed $i_1, j_1, i_3, j_3 \in \mathbb{Z}_{\ge 0}$; $J, \Lambda \in \mathbb{Z}_{> 0}$; $\lambda, T, v, x, y, z \in \mathbb{C}$, the $S$ weights satisfy

\[dynamicalellipticequation2\]

\_[i\_2, j\_2, k\_2 \_[0]{}]{} & S\_[J; ]{} ( i\_1, j\_1; i\_2, j\_2 | ; v


form $W_{J; \Lambda} (i, j; i + j, 0)$. In principle, these are given by by an elliptic hypergeometric series; however, the following result, which can be found as Proposition 4.3 of [@DSHSVM], indicates that these hypergeometric weights simplify considerably when $j_2 = 0$.

\[wjj0\]

Let $i \in \mathbb{Z}_{\ge 0}$, $J \in \mathbb{Z}_{> 0}$, and $j \in \mathbb{Z}$. If $j < 0$ or $j > J$, then $W_J (i, j; i + j, 0) = 0$. Otherwise,

\[wjj20identity\]

W\_[J; ]{} ( & i, j; i + j, 0 | ; x, y )\
& =\
& .

Now we can prove .

By , we have that

\[wjt\]

&\
& =\
&\
& ,

where we have used the fact that

= ,

which holds from the second identity in and the fact that $i_1 + j_1 = i_2 + j_2$. Again applying yields

\[wlambdat\]

&\
&our stochastic fused elliptic model and instead leave such investigation for future work. Let us conclude this section by mentioning that the stochasticity of the general $S_{J; \Lambda}$ weights follows as a special case of . However, in each of the three situations explained above, this stochasticity can be checked directly. In the six-vertex and higher spin elliptic models (given by and ), this is a consequence of . In the elliptic variant of the $q$-Hahn boson model (given by ), this is a special case of the elliptic Jackson identity .

Dynamical Higher Rank Vertex Model {#RankDynamical}
==================================

In this section we apply the stochasticization procedure to solutions to the Yang-Baxter equation coming from higher rank vertex models, which were studied previously in [@CSVMST; @CDFSVMD; @SM]; this will give rise


n\_4” n\_6’]{} (v)\
& = \_[***n***’]{} T\_[n\_3 n\_5 n\_6]{}\^[n\_3’ n\_5’ n\_6’]{} (v) T\_[n\_2 n\_4 n\_6’]{}\^[n\_2’ n\_4’ n\_6”]{} (v) T\_[n\_1 n\_4’ n\_5’]{}\^[n\_1’ n\_4” n\_5”]{} (w) T\_[n\_1’ n\_2’ n\_3’]{}\^[n\_1” n\_2” n\_3”]{} (w),

where the sum is over all nonnegative integer sets $\textbf{\emph{n}}' = (n_1', n_2', n_3', n_4', n_5', n_6')$.

Additionally, if $v \in (0, 1)$, then $T_{n_1 n_2 n_3}^{n_1' n_2' n_3'} \ge 0$ for each $n_1, n_2, n_3, n_1', n_2', n_3' \in \mathbb{Z}_{\ge 0}$.

\[arrowtprobability\]

Observe that the weight $T_{n_1 n_2 n_3}^{n_1' n_2' n_3'} (v)$ from has the following probabilistic interpretation. Each arrow entering a vertex $u$ through the $n_1$ (or $n_3$) direction deterministically exits $u$ through the $n_1'$ (or $n_3'$) direction. Furthermore, if an arrow enters $u$ through the $n_2$ direction, then a Bernoulli $0-1$ random variable $\chi$ with $\mathbb{P}[\chi = 1] = v$are consequences of the third identity in , , and the facts that $n_1 + n_2 = n_1' + n_2'$ and $n_2 + n_3 = n_2' + n_3'$.

The remaining results given by , , and the last statement of the proposition follow from combining with and (alternatively, each of these can be verified directly, independently of the content of ).

Let us briefly outline an alternative way to verify that the $T$ weights from satisfy . To that end, consider the two tetrahedra depicted in , and fix the numbers $n_1, n_2, n_3, n_4, n_5, n_6$ of arrows entering each tetrahedron. Under the probabilistic interpretation of the $T$ weights from , the left and right sides of denote the probabilities that the numbers of arrows exiting the left and


for the asymmetric simple exclusion process. , 279(3):815–844, 2008.

C. A. Tracy and H. Widom. Asymptotics in [ASEP]{} with step initial condition. , 290(1):129–154, 2009.

A. B. Zamolodchikov. Tetrahedra equations and integrable systems in three-dimensional space. , 79(2):641–664, 1980.

A. B. Zamolodchikov. Tetrahedron equations and the relativistic [$S$]{}-matrix of straight-strings in [$2+1$]{}-dimensions. , 79(4):489–505, 1981.

[^1]: Although arbitrarily many arrows are allowed along vertical edges through shaded vertices, no edge in accommodates more than one arrow. The reason for this is that will be reused to depict , where at most one arrow is allowed per edge.

[^2]: For convenience, we will sometimes draw these lines as curves in the plane to simplify diagrams.

[^3]: This triple need not be unique. In fact, it usually will not be, and this non-uniqueness will give rise to additional, dynamical parameters.

[^4]:reset) and then back to UK again, removing the indicator would not be convenient.
I thought there might be a setting somewhere, which is why I asked the question, but it turns out it's a bug.


Q:

XPath select node with periods

I have an XML document where some of the nodes have a . in their name:
<com.site.blah>
   <id>asdkjasd</id>
   <com.site.testing>
       <name>test</name>
    </com.site.testing>
</com.site.blah>

If I try @doc.search("/*/id").first.xpath, it returns /com.site.blah/id, but if I then do: @doc.search("/com.site.blah/id").first.inspect it returns nil.
I want to be able to make an XPath query to select the name under com.site.testing, but it keeps rejecting my queries.
Any ideas?
(I am using hpricot if it makes a difference)

A:

Your XPath library is broken. An XPath name test is a QName (http://www.w3.org/TR/xpath/#NT-NameTest), which, after following the rabbit hole of EBNF, includes periods (http://www.w3.org/TR/REC-xml/#NT-NameChar). Report the error to the developers.
As a workaround, neither of the escape mechanisms mentioned in the comments are part of XPath, butI got to meet Helmut Katzgraber, a condensed-matter physicist who’s one of the world experts on quantum annealing experiments, to talk to him about their new response paper. Helmut was clear in his prediction that, with only small modifications to the instances considered, one could see similar performance by the D-Wave machine while avoiding the reduction to perfect matching. With those future modifications, it’s possible that one really might see a D-Wave speedup that survived serious attempts by skeptics to make it go away.

But Helmut was equally clear in saying that, even in such a case, he sees no evidence at present that the speedup would be asymptotic or quantum-computational in nature. In other words, he thinks the existing data is well explained by the observation that we’re


A general mechanism for the copper- and silver-catalyzed olefin aziridination reactions: concomitant involvement of the singlet and triplet pathways.
The olefin aziridination reactions catalyzed by copper and silver complexes bearing hydrotris(pyrazolyl)borate (Tp(x)) ligands have been investigated from a mechanistic point of view. Several mechanistic probe reactions were carried out, specifically competition experiments with p-substituted styrenes, stereospecificity of olefins, effects of the radical inhibitors, and use of a radical clock. Data from these experiments seem to be contradictory, as they do not fully support the previously reported concerted or stepwise mechanisms. But theoretical calculations have provided the reaction profiles for both the silver and copper systems with different olefins to satisfy all experimental data. A mechanistic proposal has been made on the basis of the information that we collected fromtheodolites, global positioning system (GPS)-based systems, geophones, accelerometers, etc. However, none of them are able to fulfill all the requirements previously described.

In recent years, a novel set of solutions has emerged: video-based sensors. This promising and quickly evolving technology has been driven by the continuous improving of the features of digital video cameras resulting in rapidly decreasing costs. Today it is possible to get a commercially-available 4K video camera at accessible prices. In addition, the development and wide availability of digital image processing (DIP) software, initially developed for applications very different from bridge monitoring, allows one to simplify post-processing tasks to extract the required information. While this is a promising technology, it is not a technology mature enough to be widely implemented for bridge monitoring purposes. Several challenges


part and the movable part, as illustrated in [Figure 1](#sensors-18-00970-f001){ref-type="fig"}.

The fixed part is placed at a non-moving location and to remain fixed at all times. It is composed by a support fixture holding two laser emitters. The laser emitters used in this research are green dot lasers with a wavelength of 532 nm, output power 5 mW, class IIIA and a beam divergence of 1 mrad.

The movable part is placed on the structure and moves jointly with it. It is composed of a video camera and a measurement panel placed on a support fixture. The video camera used in this research was a Lumix DMC-G80 (Panasonic, Osaka, Japan) with 16 MP and image stabilization, type 5-axis/5-stop, Dual IS, with a recording speed of 60 fps and an opticalColoring is cool. There, I said it! Whether you’re eight or eighty years old, there’s always a delightful zen that can be achieved when you take out some crayons and flex your creativity in a coloring book.

The folks at Disney Research have captured that zen and added a little extra whimsy to it — creating quite the technical feat in the process. In a paper released today, a group of researchers have developed a way to take advantage of Augmented Reality and turn a 2D coloring experience into a 3D one.

The app actually captures the texture of the object in real-time, allowing the unique color patterns on the page to be accurately displayed on a 3D model. Those models actually move around with pages, and have special animations


complete list of stimuli). The distinction between MAN and NONMAN was pretested in a group of raters who did not participate in the fMRI experiment (*N* = 16), who scored for each verb how much they associated that action with their hand(s) on a 1- to 7-point scale. MAN words were significantly more associated with hand actions than NONMAN words \[*t*(94) = 23.60, *p* \< 0.001; mean MAN = 5.55, SD = 0.53; mean NONMAN = 2.04, SD = 0.83\]. Raters also indicated whether they preferentially acted out the hand actions with the left, right, or with both hands. Materials were selected to ensure that the number of raters indicating to use both hands in that particular action, was low (out of 16 raters: mean = 3.36, SD = 1.89, median = 3, mode = 2). MAN and NONMAN word lists did not differ in imageability (assessed by the sameas an experimental tool (Longcamp et al., [@B26], [@B27]; Lewis et al., [@B25]). Earlier studies of motor execution differences in left- and right-handers did not observe such lateralization differences (Kim et al., [@B21]; Kloppel et al., [@B22]). However, a crucial difference with the present study is that in these previous studies very simple hand actions were used. For instance in Kim et al., the hand actions were simple finger-thumb oppositions. In Kloppel et al. ([@B22]) the hand actions involved pressing a button. Indeed we previously also did not observe the clear-cut difference in lateralization between left- and right-handers when they performed simple contractions and extension of the fingers (Willems and Hagoort, [@B48]). Future research should more systematically investigate how the complexity of performed/imagined actions influences the amount of


actions that they imagine as compared to visual motor imagery in which participants are instructed to focus on the visual aspects of motor imagery. Guillot et al. ([@B16]) observed increased activations during kinesthetic motor imagery compared to a low-level control condition in somatosensory cortex. Such an effect was not observed when comparing visual motor imagery to the same control condition. A direct comparison between kinesthetic and visual motor imagery, however, did not reveal increased activation during kinesthetic motor imagery in S1. In our experiment we did not specifically instruct participants to focus/direct attention on one of these aspects of motor imagery and this interpretation is hence speculative.

[^1]: Edited by: Olaf Blanke, Ecole Polytechnique Fédérale de Lausanne, Switzerland; University of Geneva, Switzerland

[^2]: Reviewed by: Thomas F. Münte, University ofsomething similar to the “rail snehidham”. Of course, in some few cases this will become a true genuine friendship. But very rarely.

Old friendships are the ones that did not start in a train journey. It is a genuine friendship. Genuine friendship involves a shared sense of caring and concern, a desire to see one another grow and develop, and a hope for each other to succeed in all aspects of life.

Just like the train journey, new friends are gone after a certain time. Then we get ourselves into loneliness that makes us really depressed. Then we start to miss our old friends, especially at hard times. We wish they were here. We wish we could see them. We wish we could do the same old things together. We


readjustment is not necessary.
In an embodiment, the reception device of the magnetometer has a counter with which cycles of a signal that oscillates at the resonant frequency can be counted, and the counter is fashioned to emit a counter reading that is one indicator for the electrical charge of a current that corresponds to the magnetic field to be measured. When the specimen of the magnetometer is arranged within an electrical coil in which this current flows, a current-time integral of the current can be directly measured and is available as a digital quantity as the counter reading emitted by the counter.
In another embodiment, the transmission device of the magnetometer has a phase shifter for generating at least a 180xc2x0 phase shift of the transmission signal. This 180xc2x0phase shift can thereby be generated either following a prescribable time duration or dependent on the amplitude of the mixed signal. As a result, the signal amplitude of the mixed signal, that decreases over time, is maintained at a relatively high level by re-exciting the spins in the specimen, so that a consistently high signal-to-noise ration can be achieved. In particular, the generation of 180xc2x0 phase shifts dependent on the amplitude of the mixed signal has the advantage that changes in the T2 decay time of the specimenxe2x80x94due, for example, to field inhomogeneities of the magnetic field to be measuredxe2x80x94can be dynamically adapted.
In a further embodiment, the transmission device of the magnetometer is fashioned such that a magnetization amplitude of the transmission signal is smaller by factor of


their strong bent on reducing the debt …

My natural desire to involve students in real-world problems matched well [with] SIFE’s mission to have university students go out into the community and teach about business.

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You note in the book that your team’s mission statement was to “help the citizens in our community become business literate, so that everyone has the opportunity to lead happy and productive lives.” Does becoming “business literate” there effectively mean becoming less critical of companies like Wal-Mart?

I think that’s what SIFE would want us to believe. But … we wrote that with my team leaders at that time because business literacy … was an important initiative of the governor’s office …

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A lot of K through 12 educators really detest the fact that business, quote, “sticksyou agree?

Absolutely …

Why was Sam Walton able to pay below minimum wages back in Bentonville and Fayetteville and Rogers, Ark.? ... The men, as the store managers, were kind of like the head of the farm. They were the breadwinner. And now, if the man is running the store here, that used to be viewed kind of like ladies’ work. But if he could be the manager or the district manager, he was still the boss … He could hire the women to be the clerks, to do the heavy lifting if you will, the stocking of the shelves …

People are coming off the farm after 1973, where you have the industrialization of the farm … That man has to do something, so he migrates to the city.


another. All people were going to have to work together to solve the country’s problems. Only in that way could Americans make a more perfect United States.

There’s so much wrong with this Common Core garbage. First, lots of white people voted for Obama. Second, our country’s history of slavery is pretty long over. That racism is still even an issue has way more to do with what happened after slavery was abolished. As in, all the ways that the civil government ensured that former slaves would remain second-class citizens—from Jim Crow laws to affirmative action to welfare. Third, Obama is not the first person “to speak to Americans about race.” And he has not been the most effective either. In fact, Obama has not been effective on thesubject of racism at all. Racial tensions are worse now than they were when he came into office.

But let’s set that all aside for a moment. Why are children in fourth grade reading Common Core biographies of a still living person? If it is not for the purpose of indoctrination, what purpose does it serve? Obama’s life and work have not yet been firmly established in history. We have not yet had time as a country to determine Obama’s legacy. The reason why children used to read books about George Washington and Ben Franklin was that we could be reasonably sure what the upshot of their actions had been.

And most countries recommending that their children study living public figures are Communist countries. You can imagine Chinese kids studying


Audio sources such as televisions and radios are provided in many public or commercial spaces such as hotels, airports, restaurants, bars, etc. In some settings, the audio source sound is kept at a low volume, so as not to disturb customers or patrons. In some settings, the sound is even turned off. Users interested in watching the television programming, or listening to the radio programming, must then move closer to the source or ask the proprietor or employee of the establishment to adjust the volume.response of different types and subtypes of brain tumors. This culminated in 2016 with the new World Health Health (WHO) of brain tumors \[[@B7],[@B8]\] which separated astrocytic tumors based on the isocitrate dehydrogenase (IDH) gene status: wild-type or mutant further underlining the importance of biomarkers in the diagnosis of HGG. Another enzyme, O6-methylguanine-DNA-methyltransferase (MGMT) plays a pivotal role in the mechanisms implicated in DNA repair and subsequently in the way MGs respond to TMZ treatment \[[@B6],[@B9]\] given than TMZ's activity is based on DNA damage via alkylation of the purine bases. MGMT silencing through MGMT gene promoter methylation is directly linked to the tumor's incapacity to repair the DNA damaged by TMZ \[[@B9]\]. Unfortunately, the MGMT-related DNA repair system is not the only mechanism employed by glioma cells


the proliferation and progression of different types of cancer \[[@B32],[@B33],[@B34]\]. In our experiment, we determined the effect of β-arr 1 overexpression, induced by plasmid transfection on the TMZ treatment response of two MG cell lines (U343 MGa and CL 2:6), at 24h, 48h and 72h.

After 24h, β-arr1 transfection slightly counteracted the cytotoxic effect of 200μM TMZ by 4% but the results were not statistically significant (p\>0.05). The cytotoxic effect induced by 250μM or 300μM TMZ treatment at 24h was not affected by β-arr 1 transfection (Fig. [3](#F3){ref-type="fig"}A).

![The effect of β-arr 1 transection on U343 MGa cells response to TMZ treatment. U343 MGa cells (blue bars) and β-arr 1 transected MGa cells (red bars) were treated with 200µM, 250µM or 300µM of TMZ for 24 hours (A), 48 hoursThree of Allen's players - Rupp, Smith and Ralph Miller (who won 674 games at three schools) - are in the Naismith Memorial Basketball Hall of Fame. So is Allen and so is John McLendon, who was the first black man to graduate from Kansas with a degree in physical education and went on to win 523 games at three of the South's traditionally black colleges. Williams is enshrined in Springfield as well. Self may be on the way.


House was used as the local Town Hall, but today it is used as an Arts Centre.  The drawing room on the upper floor (now the Londonderry Room) is still used for meetings and exhibitions.

References

External links
Newtownards Historical Series #9 The Market House, a geocaching site

Category:Historic sites
Category:City and town halls in Northern Ireland
Category:Prisons in Northern Ireland
Category:Newtownards
Category:1767 in Ireland
Category:Arts centres in Northern Ireland1.. Introduction
================

Pressure-sensitive paint (PSP) has been widely used in aerospace applications \[[@b1-sensors-11-06967]\]. It uses a photophysical process of oxygen quenching to relate an oxygen pressure of a testing fluid to a luminescent signal. A PSP is composed of a luminophore and a supporting matrix. The former gives a luminescent signal and the latter holds the luminophore onto a testing article. A PSP can be categorized by the supporting matrix: polymer PSP and porous PSP. The supporting matrix greatly influences the response time of a PSP \[[@b2-sensors-11-06967]\]. The former uses a polymer as a supporting matrix. Gaseous oxygen needs to permeate into this layer to cause the oxygen quenching. This limits the time response of this type of PSP on the order of seconds or sub-seconds. The latter uses


the temperature increases, we can see the spectrum decrease due to the thermal quenching \[[@b1-sensors-11-06967]\]. We can see that a luminescent peak exists around 620 nm. As described in Section 2.2, we integrated an obtained spectrum within 620 ± 20 nm to determine the luminescent intensity, *I*, for a given pressure and a temperature.

3.2.. Signal Level
------------------

The signal level, *η*, was determined from [Equation (2)](#FD2){ref-type="disp-formula"}, which was shown in [Figure 5](#f5-sensors-11-06967){ref-type="fig"}.

The value of *η* was related to the polymer content. As a general trend, there was a peak that gave the maximum *η*. It would lie between 50 and 70% of the polymer content. Say that the minimum *η* was around 40%, more than a factor of two increase in *η* was obtained by controlling the polymer content. Duetime response. The signal level and temperature dependency showed a peak in the polymer content between 50 and 70%. By controlling the polymer content, the signal level was changed by more than a factor of two. The pressure sensitivity was fairly constant and ranged from 0.8 to 0.9 %/kPa. The time response was improved by lowering the polymer content. The variation of the time response on the order of milliseconds to ten seconds was seen. However, below the content of 40%, the time response approached the limitation of the apparatus. We used a weight coefficient to optimize the resultant PSPs. We could determine an optimum of the polymer content to provide an optimized PC-PSP for our sensing purposes.

![Schematic description of a polymer ceramic PSP (PC-PSP).](sensors-11-06967f1){#f1-sensors-11-06967}

![Schematic of the PC-PSP


  PtTFPP [^b^](#tfn2-sensors-11-06967){ref-type="table-fn"}/TiO~2~[^d^](#tfn4-sensors-11-06967){ref-type="table-fn"}/B-1035   ∼0.8 (%/kPa)   NA             61 μs to 100 ms   polymer content from 2.6 to 24% \[[@b8-sensors-11-06967]\]
  PSP thickness not specified                                                                    state television aired the Amiri video. Within a day, the CIA posted their Amiri video on YouTube, with a user identification of "shahramamiri2010."

Amiri Faces Tough Decisions

The Iranian government has since formally requested the U.S. government to return Amiri, accusing the Americans of holding him against his will. A spokesperson for the State department has acknowledged that the U.S. government has received the request, but has had no further comment.

"The United States doesn't force people to defect—that's a decision they make themselves," said a U.S. official. "Mr. Amiri wasn't kidnapped, and he certainly wasn't tortured. That's absurd. The guy has internet access and the ability to make and transmit videos. Let's get real. If you look at defectors as a group, without commenting on any particular individual, some adjust


Consecutive analysis of mutation spectrum in the dystrophin gene of 507 Korean boys with Duchenne/Becker muscular dystrophy in a single center.
Duchenne and Becker muscular dystrophies (DMD and BMD) are allelic X-linked recessive muscle diseases caused by mutations in the large and complex dystrophin gene. We analyzed the dystrophin gene in 507 Korean DMD/BMD patients by multiple ligation-dependent probe amplification and direct sequencing. Overall, 117 different deletions, 48 duplications, and 90 pathogenic sequence variations, including 30 novel variations, were identified. Deletions and duplications accounted for 65.4% and 13.3% of Korean dystrophinopathy, respectively, suggesting that the incidence of large rearrangements in dystrophin is similar among different ethnic groups. We also detected sequence variations in >100 probands. The small variations were dispersed across the whole gene, and 12.3% were nonsense mutations.Johnson County of local transmission. JCDHE is working to identify any close contacts of the woman. Those who were exposed will be contacted by JCDHE as soon as possible.

Health officials said the woman is hospitalized and doing well, and her family is in quarantine.

"It is important to remember to take basic precautions like washing your hands, covering your cough and staying home when you are ill. The local transmission has been expected, most people with mild symptoms will recover in a short amount of time," said Mary Beverly, JCDHE interim director.


Q:

Return "Iterable" Numbers for Indices in Python Pandas

Hi I am really new to Pandas. I tried to figure out what's going on with the datatype here but so far I am unable to go very far.
What I intend to do is very simple indeed. I am searching for the index of a DataFrame data2 with the nearest time to the target time in data1.
Since data1 and data2 are very similar, just that there are some minor time difference due to slightly different sampling rate, I attach only the sample of data1 here:

I did something like this in the search of closest match data by comparing the timestamp in data2 to timestamp in data1:
idxcollect = []
for loopidx, tstamploop in enumerate( tstamp_data1[820990:821000] ):
    idxtemp = data2[If you have any problem please leave a comment below we will help you. Explore infinite worlds and build everything from the simplest of homes to the grandest of castles.

1035 have been trying many of the Portal versions listed above they don’ t seem to work. We do not modify or edit the files in any way! At first people built structures to protect against nocturnal monsters but as the game grew players worked together to create wonderful.Features % } Features ( { { features. Since Minecraft saved games contain every single element of the world the player is playing in it has much more in common with 3D world, map terrain editors than traditional saved game editors. The game allows players to build with a variety of


Evaluation of two short-term anesthetic protocols in captive juvenile pronghorn (Antilocapra americana).
Safe and efficacious anesthesia is required to facilitate biomedical procedures in pronghorn (Antilocapra americana). Two short-term anesthesia protocols were evaluated in 10 juvenile male pronghorn raised in captivity. Following i.m. medetomidine (0.1 mg/kg), pronghorn received either intravenous propofol (P) or ketamine (K). Behavioral and physiologic parameters were assessed for 15 min prior to atipamezole (0.2 mg/kg, i.m.) administration. Quantitative and qualitative values following both protocols were similar. Mean induction times were 80 +/- 23 and 75 +/- 15 sec after K and P, respectively. Arterial pressure decreased over time, and hypoxemia was evident (PaO2 51 +/- 4 mmHg) following both treatments.      which is a :math:`(L_i, )`-shaped int array.
        dropout (float): Dropout ratio.

    Returns:
        list of ~chainer.Variable: Output variables. i-th element in the
        list is an output variable, which is a :math:`(L_i, N)`-shaped
        float array. :math:`(N)` is the number of dimensions of word embedding.

    """
    x_len = [len(x) for x in xs]
    x_section = np.cumsum(x_len[:-1])
    ex = embed(F.concat(xs, axis=0))
    ex = F.dropout(ex, ratio=dropout)
    exs = F.split_axis(ex, x_section, 0)
    return exs

def block_embed(embed, x,


        self.encoder = encoder
            self.linear = L.Linear(encoder.output_size, n_class)
            self.batchnorm = L.BatchNormalization(n_class)
            # dropout
        self.dropout = dropout

    def load_glove(self, raw_path, vocab, size):
        print("Constructing embedding matrix")
        embed_w = np.random.uniform(-0.25, 0.25, size)
        with open(raw_path, "r") as f:
            for line in tqdm(f):
        Cornelius Ferguson, better known as Chicago footwork producer Traxman, has announced a new full-length. Tekvision arrives November 3 on Teklife, the footwork label originally founded by DJ Rashad. Traxman has released the first track from the LP, entitled “Be Gagen” featuring DJ Earl. Find the LP’s tracklist and listen below. Traxman’s last full-length was 2014’s Da Mind of Traxman Vol. 2, which is the sequel to 2012’s Da Mind of Traxman. He released Teklife Vol. 3: The Architek in 2013. Revisit Pitchfork’s feature on Teklife.

Tekvision:

A1 Be Gagen [ft. DJ Earl]

A2 Drop It Down

A3 Control Ya Bitchezzz

A4 Gone Girl

B1 Tone Deaf

B2 Let Me Get Up

B3 Twist Da Party Out

B4 Whop Line


Impressed with the costumes, the overall look, the extensive storyboards and workshops, Roy signed on. “Sometimes I feel, Shiv Puran has the potential of making such a lovely contemporary drama series,” says the actor who feels Raina makes a beautiful Lord Shiva, and can slip into any role with amazing ease.

For her own part, to get into the role of Sati, Roy had to go through at least eight look tests to get it right. She breaks down Sati’s appeal for her. “She is an iron princess and an innocent girl at the same time. She was very human, and her love with Mahadev was amazing, for I consider it the first love story of the Universe,” she says.

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Growing up in a middle class-family in Cooch Behar, aDeveloping patient and family education programs for a transplant center.
Patient and family education is an important component of the organ transplant programs at the University of Nebraska Medical Center. The Medical Center is in the process of planning a new transplant center which will employ the family-centered, educationally-intensive cooperative care concept. This approach was chosen as the model for the delivery of care at the Lied Transplant Center because it emphasizes efficient, effective clinical care by requiring active participation by the family or essential other, thereby better preparing both the patient and the family for the transition to home and to the community. This article presents the evolution of patient education in our transplant programs, discusses the educational needs of transplant patients across the continuum of care, provides


                                    const Polyhedron& bounding_polyhedron,
                                         CGAL::Random* p_rng = nullptr)
    : Base(p_rng) , borders_detected_(false)
  {
    stored_polyhedra.reserve(std::distance(begin, end)+1);
    if(begin != end) {
      for (; begin != end; ++begin) {
        stored_polyhedra.push_back(**begin);
    for Cera is to create a digital doorway to the over 65s, and curate services with partners to help them live more independently. Thanks to technology, anything is possible – from integrating our healthcare technology with retail, food delivery and wearables, to enabling people to stay in their homes with conditions that usually require them to be in a hospital or facility.

The social care system is not beyond repair, but we need to act quickly. With advances in technology, the start of better service integration, and councils such as Surrey proposing council tax hikes to relieve pressure on social care services, there’s no reason why 2017 shouldn’t be a year of positive change.


has the power to do in the first session following the election at which the statutory initiative is passed.

Further support for the desirability of Constitutional change comes from recent history. Since 1970, there have been 81 times that Coloradans have believed that it is necessary to change the Constitution rather than propose legislation. In the future there will continue to be times that the citizens want to assert their right to make constitutional changes, and the bar should not be set so that hardly any citizen initiative can get over it.

As an advocate for universal health care, the Foundation believes that the citizen’s initiative process for Constitutional change is important to Coloradans. Polling shoes the majority of Americans supporting universal health care. Both the Colorado legislature and federallocal time (03:00 GMT) as the frigate, part of Nato's fleet, was sailing inner fjords for training, officials say.

"Due to the damage to the frigate it was moved to a safe place," Nato's Allied Maritime Command said in a statement.

The tanker had already left Equinor's Sture oil terminal with a cargo of North Sea crude, Reuters news agency reports.

The tanker, which had an uninjured crew of 23, returned to port for inspection.

An unnamed official told AFP news agency that a "small oil slick" had been detected from the frigate.

"It took on a lot of water and there is a real danger that it sinks where it is," the official said.

media caption Nato holds biggest military exercise since Cold War


evi-
dence that had been before the state PCR court. Ultimately, the
district court rejected Teresa's § 2254 application and granted sum-
mary judgment to the State.1 On appeal, Teresa urges us to find that
_________________________________________________________________
1 The § 2254 application named as respondents Michael Moore, Com-
missioner, South Carolina Department of Corrections, and Charles M.
Condon, Attorney General for the State of South Carolina. For ease of
reference, we refer to respondents as "the State."

                    2
the South Carolina Supreme Court actually considered this evidence
and disposed of her petition on the merits, and she suggests that the
appropriate remedy is to return the matter to district court for recon-
sideration of her claims in light of this evidence.

We holdthe magistrate judge directed the parties to brief
the issue of whether the newly submitted affidavits and psychological
report could be considered. Before the magistrate judge issued a rec-
ommendation, however, Teresa returned to state court and filed a peti-
tion for a writ of habeas corpus in the original jurisdiction of the
South Carolina Supreme Court. In this petition, Teresa advanced the
same two grounds for relief that she raised in her§ 2254 application:
(1) that she was denied effective assistance of counsel because of the
joint representation, and (2) that her "waiver of her right to conflict-
free representation was the invalid product of battering, domination
and abuse by her co-defendant." J.A. 188. In support of the petition,


consider this newly pre-
sented evidence on summary judgment if the state supreme court dis-
posed of the habeas petition on the merits, which would require con-
sideration of the new evidence. Conversely, if the state supreme court
found the petition procedurally barred, and therefore did not consider
the new evidence, the district court could not take the new evidence
into account when considering Teresa's § 2254 claims. Cf. Ylst v.
Nunnemaker, 501 U.S. 797, 801 (1991) ("State procedural bars are
not immortal ... [i]f the last state court to be presented with a particu-
lar federal claim reaches the merits, it removes any bar to federal-
court review that might otherwise have been available."). This much
the parties agree upon.

B.

We turn, then, to the question of whether the South Carolina
Supreme Court, in its original jurisdiction, ruled on thethe procedural posture of the state decision and the motion
papers submitted to the state court).

C.

Guided by these general precepts, we turn to consider whether the
South Carolina Supreme Court's one-sentence order denying Teresa's
petition for a writ of habeas corpus "fairly appears" to rest on federal
law.

1.

The order of the South Carolina Supreme Court makes no mention
of federal law. Teresa contends that this omission is not a meaningful
clue as to the basis of the decision since the order does not mention
state law either. Contrary to Teresa's position, however, the Supreme
Court has made clear that the failure to mention federal law supports
the conclusion that the state order "fairly appears" to rest on state law,
even though the state order does not refer expressly to state law. See
Coleman, 501 U.S. at 738 ("It is


(30) days to serve and file an
          answer to the complaint. The Supreme Court may provide
          for discovery, fact finding and/or a briefing schedule as
          necessary.

Rule 229(c), SCACR (emphasis added).10 Thus, a respondent need not
_________________________________________________________________
10 Teresa combined her petition for original jurisdiction and the com-
plaint detailing her claims for relief.

                    17
even address the merits of a habeas petition unless the court first
decides to exercise its original jurisdiction and grants the petition.

Here, the State filed a return to Teresa's petition urging the court
not229(a),
SCACR ("The Supreme Court will not entertain matters in its original
jurisdiction when the matter can be determined in a lower court in the
first instance, without material prejudice to the rights of the parties.").
In view of the fact that Teresa's habeas petition is nothing more than

                     18
an attempt to revitalize her first PCR claim, we are convinced that the
Supreme Court of South Carolina did not take the"extraordinary"
step of exercising its original jurisdiction to review her petition on the
merits.

In sum, the circumstances surrounding the entry of the state order,
coupled with its failure to mention federal law, leave us convinced
that the state supreme court did not visit the merits of Teresa's


sent the SIGINT signal by pressing CTRL+C on the keyboard. Using the timeout command we can tell timeout to exit after 10 seconds.

That's it, simple and to the point. Now let's explore some of the options for timeout.

Send Specific Signal with Timeout

There are may different signals you can send to a command. Outlining all of them is outside the scope of this tutorial. Instead we will focus on how to send a specific signal.

By Default the timeout command sends a SIGTERM or termination signal. We can specify which signal to send by using the -s (--signal) option followed by the desired signal. For example, let's say we wanted to send the SIGINT signal to the top command after 10 seconds. We can specify the signal by name orproduced using acrylonitrile. Such compositions were somewhat higher in viscosity than desired in some applications. Further, such compositions were at least primarily used commercially in producing foams under conditions such that the heat generated during foaming is readily dissipated (e.g.--the foams have a relatively thin cross-section) or under conditions such that relatively little heat is generated during foaming. When polyurethane foams were produced under conditions such that the heat generated during foaming was not readily dissipated, severe foam scorching usually resulted. Later, polymer/polyol compositions produced from acrylonitrile-methylmethacrylate monomer mixtures were commercialized and were convertible to polyurethane foams having reduced scorch.
More recently, polymer/polyol compositions produced from acrylonitrile-styrene monomer mixtures have been used commercially. Use of low ratios of acrylonitrile-to-styrene in the monomer mixture affords polymer/polyols that do not give


his organic wool-and-cotton, hypoallergenic, temptingly chewable comforter.

Next, we started seeing changes in J.’s school reports… An aggression is defined as any attempt or instance of hitting, kicking, biting, or pinching another person. For the past year, he’d consistently had 30 to 50 aggressions in a school day, with a one-time high of 300. The charts for June through July, by contrast, showed he was actually having days—sometimes one after another—with zero aggressions.

This post is likely to elicit strong opinions; I would encourage everyone to at least browse the original source articles rather than basing judgments only on the excerpts above.

Dude. All i gots to say is that pots my friend and has been for a long time. The fact that it's illegal is my enemy and has beenOlympic Photo Of The Day: Giant Head Edition

Imagery from Russia's recent past – including the hammer and sickle that adorned the flag of the Soviet Union – is seen in the Opening Ceremony of the Sochi Olympics Friday. The display came in a portion of the program describing Russia's industrial growth.


unit results in the type- (i.e. I, II, III, IV, V, IC) and group- (i.e. 3,4; 6; 7,8) specific antigenic determinants [@pone.0046095-Stagg1]. The O-acetyl on Rha^I^ defines group 6 determinant in serotype 3a, 3b, 1b, and 4b strains [@pone.0046095-Clark1], [@pone.0046095-Verma1]. Determinants specific for type I, IC, II, IV, V and group 7,8 antigens are associated with glucosylation on various sugar residues in the tetrasaccharide unit. The genes responsible for the O-antigen glucosylation \[*gtrA*, *gtrB*, and *gtr* (type)\] have been identified [@pone.0046095-Stagg1], [@pone.0046095-Adams1], [@pone.0046095-Adhikari1], [@pone.0046095-Guan1], [@pone.0046095-Mavris1]. They are arranged in a single operon known as the *gtr* cluster [@pone.0046095-Allison1]. *gtrA* and *gtrB* are highly conserved and interchangeable, while *gtr* (type) is unique and encodes the glucosyltransferase responsible for the attaching of a glucosyl group to a specific sugar inresidues denoted as follows: G, Glc; GN, GlcNAc; RI, Rha^I^; RII, Rha^II^; RIII, Rha^III^. In the spectrum of the transformant 51580_Xv O-polysaccharide, the annotations for the signals of the minor bisphosphorylated O-unit are italicized. The most important difference between X and Xv is the presence in the latter of peaks for ethanolamine, which are annotated as EtN 1 and EtN 2. The different positions of the signals for C3 of Rha^II^ (non-phosphorylated in X and phosphorylated in Xv) are shown by a dotted line.](pone.0046095.g002){#pone-0046095-g002}

The NMR spectra of the serotype Xv O-polysaccharide were assigned and analyzed using two-dimensional ^1^H,^1^H and ^1^H,^13^C NMR techniques ([Table 1](#pone-0046095-t001){ref-type="table"}) [@pone.0046095-Duus1]. Significant downfield displacements due to phosphorylation were observed for the signals of H3 and C3 of Rha^II^ to δ~H~ 4.35 and δ~C~ 76.5


from these 5 strains, they all did not react with monoclonal antibody MASF IV-1. Plasmid profile analysis indicated that the pSFxv_2- like plasmid is present in these 5 strains. Sequencing of the *lpt-O* gene from these 5 strains revealed that all had a single base deletion at the position of 295, which resulted in a stop codon at amino acid 99, and abolishes the function of the gene without the presumed sulfatase domain (from aa165 to aa465) of Lpt-O. We cloned the defective gene and showed that it cannot convert serotype X strain 51580 to serotype Xv, confirming that the single base deletion inactivated the gene.

10.1371/journal.pone.0046095.t003

###### Distribution of the *lpt-O* gene in *S. flexneri* strains detected by PCR.

![](pone.0046095.t003){#pone-0046095-t003-3}

  Serotypes        putting you in jail, putting you in a room, abuse, humiliating you or ruining your reputation," he said.

"They could take away my passport, they could take away all my IDs and say, 'There you go, you can't live your life anymore.'"

Applying for asylum

Habib is applying for asylum on two grounds: membership of a particular social group and political opinion, Khan said.

"If he says, 'I refuse to be in the military,' and if he is required under Egyptian law to be conscripted into military service, his refusal to do so is seen as an act against the Egyptian state," Khan said.

"That is how the government would crack down on him very hard and punish him."

Bashir Khan, a Winnipeg immigration lawyer, says there are two grounds for Samer Habib to


were made. The substrate specificities of enzymes with these new loops were considerably altered. For many poor enzyme-substrate pairs, the effect of fructose 1,6-bisphosphate on the steady-state kinetic parameters suggested that the substrate was mainly bound in a nonproductive mode. With one longer loop construction (BL1), activity with pyruvate was reduced one-million-fold but activity with phenylpyruvate was largely unaltered. A switch in specificity (kcat/KM) of 390,000-fold was achieved. The 1700:1 selectivity of enzyme BL1 for phenylpyruvate over pyruvate is that required in a phenyllactate dehydrogenase to be used in monitoring phenylpyruvate in the urine of patients with phenylketonuria consuming an apparently phenylalanine-free diet.the paper. After considering some examples in §\[sec6\], we consider in detail the singular locus in §\[sec7\].

Theorem \[goodness\] says that if $c_2\geq 10$ then the moduli space is good, by showing that the locus of potentially obstructed bundles has dimension strictly smaller than the expected dimension.

Furthermore, for $c_2\geq 11$ we can identify the biggest irreducible component of the singular locus, and show by a general position argument that the quadratic term of the Kuranishi map has the biggest possible rank at a general point of this component, in other words the singularity is an ordinary double point in the transverse direction.

As we shall see, for $c_2\leq 9$ the moduli space is not good, so the bound of $10$ is sharp. This answers a question of O’Grady [@OGradyBasic] who


= d-c.$$

Here is a brief account of this well-known fact (which was used implicitly in [@OGradyBasic (3.29)] for example, see also [@Nijsse]). A locally free extension exists locally if and only if $P$ is a local complete intersection. Set $U:= L'\otimes L^{\ast} \otimes K_X$ and $U|_P=U\otimes {{\mathcal O}}_P$. Consider the long exact sequence $$0\rightarrow H^0(U\otimes {{\mathcal J}}_P)\rightarrow H^0(U)
\stackrel{\epsilon}{\rightarrow} H^0(U|_P)
\rightarrow H^1(U\otimes {{\mathcal J}}_P)\rightarrow H^1(U)\rightarrow 0.$$ By duality $Ext ^1({{\mathcal J}}_P\otimes L', L)=H^1(U\otimes {{\mathcal J}}_P)^{\ast}$, so an extension restricts to a linear form $f$ on $H^0(U|_P)$ which vanishes on the image of $H^0(U)$. It is quite classical that the condition for this to yield a locally free extension, is that $f(I)\neq 0$ for any subsheaf $I\subset U|_P$ which can be supposed of rank one. Such a subsheaf corresponds to theof rank one—if it were of rank $2$ then $E$ would be of the form $(L\oplus L')(-C)$, again decomposable. We get the structure result of the proposition, away from the finite singular set of $C$. In particular, ${{\mathcal R}}$ is supported scheme-theoretically on $C$ at the smooth locus, but this then has to hold at the singular points too because ${{\mathcal R}}$ has pure dimension $1$. We get ${{\mathcal R}}=i_{\ast}(R)$ for a torsion-free sheaf $R$ of rank $1$ on $C$. The statement identifying $\phi$ holds outside the singular set of $C$, and then extends.

In terms of the description of the previous proposition, we have $$c_1(E) = L + L' - C,$$ $$c_2(E) = c_1(L)c_1(L') - (L.C + L'.C) +{\rm deg}_C(R) .$$ On any surface $X$ which admits a


the Cayley-Bacharach property for quadrics in ${{\mathbb P}}^3$.

\[extensionexists\] Suppose $P$ is a zero-dimensional subscheme. Then there exists an exact sequence $$0\rightarrow {{\mathcal O}}_X(-1)\rightarrow E \rightarrow {{\mathcal J}}_P\rightarrow 0$$ with $E$ locally free, if and only if $P$ is a l.c.i. Cayley-Bacharach for quadrics in $X$. In particular, in case (i) of Proposition \[mainclassif\], we can add the condition that $P$ is Cayley-Bacharach for quadrics.

For any locally free extension fitting into with $P$ nonempty, the bundle $E$ is stable and potentially obstructed with $c_1(E)={{\mathcal O}}_X(-1)$ and $c_2(E) = d$.

The first part is just Lemma \[totallysuper\]. For the last paragraph, the co-obstruction $\phi$ is given by the obvious factorization. The fact that $E$ is always stable comes from $H^0(E)=H^0({{\mathcal J}}_P)=0$.

Apply the discussion preceding Lemma \[gdef\], with $L={{\mathcal O}}_X(-1)$ and $L'={{\mathcal O}}_X$:\rightarrow 0.$$ On the other hand, by assumption $H^0({{\mathcal J}}_P(1))=0$ and recall that $H^1({{\mathcal O}}_X(1))=0$, so we have the sequence $$0\rightarrow H^0({{\mathcal O}}_X(1))\rightarrow H^0(P, {{\mathcal O}}_P(1))\rightarrow
H^1({{\mathcal J}}_P(1)) \rightarrow 0.$$ Using $h^2({{\mathcal O}}_X)= h^0({{\mathcal O}}_X(1)) = 4$ and $P$ has $d$ points, this gives $$h^1({{\mathcal J}}_P(1)) = d-4, \;\;\; h^1(E(1)) = d-8.$$ This implies in particular that $d\geq 8$.

\[2Plem\] Still assuming the Cayley-Bacharach property, let $2P$ denote the fat subscheme defined by ${{\mathcal J}}^2_P$. Suppose that there are no quadrics of ${{\mathbb P}}^3$ passing through $2P$. Then the obstruction is unique up to scalar, i.e. $h^2(End^0(E))=1$. Furthermore, if $\phi$ denotes a nonzero co-obstruction, the map $Ad(\phi )$ factors as the composition of a surjection followed by an injection $$H^1(End ^0(E))\twoheadrightarrow H^1(E(1))
\hookrightarrow H^1(End ^0(E)\otimes K_X).$$

Calculate with the exact sequence


way to construct subschemes $P$ which satisfy Cayley-Bacharach for quadrics, is by taking subcollections of points in $X\cap N$ where $N\subset {{\mathbb P}}^3$ is a curve. We start with a fairly easy version.

If $N$ is a rational curve and $d> h^0({{\mathcal O}}_N(2))$ then any collection of $d$ points on $N$ satisfies Cayley-Bacharach for quadrics, indeed any $d-1$ of the points already force a quadric to vanish on $N$, because any collection of points satisfies the maximal rank property for line bundles on $N\cong {{\mathbb P}}^1$.

Some possible choices for $N$ would be a line as above, or two skew lines, or three lines meeting in a rational stick-figure. These basic examples suggest looking more generally at the rational normal cubic curve $$N= \{ [1:t:t^2:t^3]\} \subset {{\mathbb P}}^3$$ which isP}}^3$ because they also vanish in transverse directions to $X$. It now suffices to have $4$ points spanning ${{\mathbb P}}^3$ in order to insure that there are no quadrics passing through $2P$. Then apply Lemma \[2Plem\].

Hence, the dimension of $M (2,-1,8)$ at a general $E$ in our family, is either $12$ or $13$; but in any case the Zariski tangent space has dimension $13$.

Points on normal elliptic curves {#sec-normalelliptic}
--------------------------------

The example of the preceding subsection can be generalized as follows.

Suppose $Y$ is a smooth elliptic curve, with a divisor of degree $4$ denoted ${{\mathcal O}}_Y(1)$. Notice that no basepoint is chosen on $Y$, and all divisors of a fixed nonzero degree are related by translation automorphisms of $Y$, so the choice of $(Y,{{\mathcal O}}_Y(1))$ corresponds to a single parameter


Y$ is a choice of $9$ out of the $20$ intersection points. The choice of $P$ is discrete so $F$ has $16$ dimensions. The space of quadrics on $Y$ has dimension $8$, so $P$ imposes $8$ conditions, and if $Y$ is in general position (indeed, if it is not in the hypersurface considered previously) then any $8$ points will also impose $8$ conditions so $P$ is Cayley-Bacharach. A general choice will satisfy this general position property because $X$ was assumed general to start with. The number of extra points is $1$ so the extension class is unique up to scalars. We obtain in this way a $16$ dimensional family of potentially obstructed bundles; at a general point the dimension of the space of obstructions is $1$. As before,$9$), then noticing that $H\cap X$ is a curve in a surface; by the result of Briançon, Granger, Speder [@BGS] the Hilbert scheme of subschemes of this curve, of length $d$, has dimension $\leq d$. For each choice of $P$, the dimension of the space of choices of $\xi$ up to scalar, is $d-c-1$. Hence we get $$\dim (\Sigma _d^c)+9-c \leq 9+d+(d-c-1),$$ giving the stated estimate after subtracting $(9-c)$ from both sides.

\[dimsigma1011\] We have $\dim (\Sigma _{10})= 19$; and for $d\geq 11$, the subset $\Sigma ^{10}_d$ is dense in $\Sigma _d$, which is irreducible of dimension $3d-11$.

The subset $\Sigma ^{10}_d$ consists of the $2d$ dimensional open set of subschemes $P$ in general position with respect to quadrics, together with $\xi$ in a space of dimension $d-11$, so $\dim


We conclude that $P\subset Y_1$.

Case (b6): the ideal of $Y_1$ is the square of the ideal of a line $L$. Vanishing along $Y_1$ imposes $7$ conditions on quadrics. The pencil of quadrics passing through $Y_1$ consists of all products of two planes passing through $L$; it has no other base points so any other point $z_1$ would impose a further independent condition giving $c\geq 8$. We conclude that $P\subset Y_1$.

Cases (b7), (b8) and (b9): The number of conditions is $9$ minus the number of intersection points. We conclude that there must be at least two intersection points or a triple intersection. In case of a double line, they are said to intersect when the double structure is planar, and a line intersecting a double line has one intersection2d-6$. Similarly, if $p'_0\leq 1$ then there is at least one other point $z$ in $P\cap L$ so $\sum n_z\geq 2$ and $\sum \delta _z\leq d-2$, hence $f\leq d+4$ and $e\leq 2d-4$. In the remaining case, $p'_0\geq 2$ and $p''_0\geq 2$. This means that $P$ contains a fat point of multiplicity $2$ in the tangent plane at the vertex, so $\mu _0=2$ and $\sum n_z\geq 2$. Therefore as before $\sum \delta _z\leq d-2$, hence $f\leq d+4$ and $e\leq 2d-4$. This completes the treatment of the last case (b9).

In the next sections we apply these considerations to the cases $d\leq 9$.

When $d=9$
----------

\[d9cor\] For a general quintic, the irreducible component of $M_X(2,-1,9)$ considered in Theorem \[only9\], is the only one; this completes the proof of that theorem.

The expected dimension is


For these cases, consider the variety of triples $(UU',P)$ where $H=UU'$ is a union of two planes, and $P\subset H\cap X$. The family of choices of $UU'$ has dimension $6$, and for each choice, the space of choices of $P$ has dimension $\leq d$ by the BGS estimate [@BGS]. Hence, the family of choices of $P$ in all cases except (d1) and (d3), has dimension $\leq d+6=15$. These strata cannot therefore give any additional irreducible components.

For case (d1), once $Y$ is fixed, the choice of $P$ is discrete unless $X$ is tangent to one of the ordinary double points. Consider the stratum of choices such that $X$ is tangent to $a$ double points. The dimension of the space of choices of $Y$ is $\leq 16-3a$ and for givenirreducible of dimension $13$, one more than the expected dimension. It contains the smooth subset of Lemma \[Ma\] as an open dense subset.

From Lemma \[inYdims\], the dimensions of the strata corresponding to case (b) are all $\leq 12$, but any irreducible component has dimension $\geq 13$ by Corollary \[dimsigmageq\]. Note that cases (c)-(f) are ruled out by the fact that $c\leq 7$ for a Cayley-Bacharach subscheme of degree $8$. Therefore, every irreducible component meets the subset of bundles of type (a); and this is irreducible by Lemma \[Ma\].

When $d=6,7$
------------

$\mbox{ }$ As pointed out in §\[sec-euler\], for $d\leq 7$ we have $h^0({{\mathcal J}}_P(1))>0$. For $d=6,7$ the subscheme $P$ is too big to be contained in $D\cap X$ for a line $D$, so it must be contained in a unique


surfaces. Arxiv preprint math/9907001 (1999).

S. Yanagida, K. Yoshioka. Semi-homogeneious sheaves, Fourier-Mukai transforms and moduli of stable sheaves on abelian surfaces. Arxiv preprint arXiv:0906.4603 (2009).

K. Zuo. Generic smoothness of the moduli spaces of rank two stable vector bundles over algebraic surfaces. [*Math. Z.*]{} [**207**]{} (1991), 629-643.

[^1]: This research is partially supported by ANR grant BLAN08-3-352054 (G-FIB) and by JSPS Grant-in-Aid for Scientific Research (S-19104002)
are your ultimate goals? Are you striving to prove yourself worthy of a great quest? Quick Build You can make a Sacred Blacksmith quickly by following these suggestions. First, Strength should be your highest ability score, followed by Constitution or Intelligence depending on your role on the battlefield. Second, choose the Clan Crafter* background. *Sword Coast Adventurer's Guide Class Features As a Sacred Blacksmith, you gain the following class features. Hit Points Hit Dice: 1d8 per sacred blacksmith level

Hit Points at 1st Level: 8 + your Constitution modifier

Hit Points at Higher Levels: 1d8 (or 5) + your Constitution modifier per sacred blacksmith level after 1st Proficiencies Armor: Light armor, medium armor, heavy armor

Weapons: Simple weapons, Maul, Warhammer

Tools: Smith’s tools Saving Throws: Strength, Intelligence

Skills: Choose two skills from Arcana,


16, your list of prepared spells can include six spells of 1st or 2nd level, in any combination. If you prepare the 1st-level spell cure wounds, you can cast it using a 1st-level or 2nd-level slot. Casting the spell doesn't remove it from your list of prepared spells. You can change your list of prepared spells when you finish a long rest. Preparing a new list of sacred blacksmith spells requires time spent in meditation or crafting: at least 1 minute per spell level for each spell on your list Spellcasting Ability Intelligence is your spellcasting ability for your sacred blacksmith spells. The power of your spells comes from your knowledge of minerals and how to use it to your advantage. You use your Intellegence whenever a sacredyour own subset of runes derived from the initial five that give specific and refined bonuses. Runes are detailed below after Divine Intervention. Divine Intervention Beginning at 10th level, you can call on your deity to intervene on your behalf when your need is great. Imploring your deity's aid requires you to use your action. Describe the assistance you seek, and roll a D20. If you roll a number equal to or lower than your Sacred Blacksmith level, your deity intervenes. The DM chooses the nature of the intervention; the effect of any Sacred Blacksmith spell or Historical Calling spell would be appropriate. If your deity intervenes, you can't use this feature again for 7 days. At 20th level, your call for intervention succeeds automatically, no roll required.


any known spell with one of the same level from any class.

Kleptomancy Damaging an enemy with this weapon has a chance to steal an item from them and place it in your possession. Table of Kleptomancy DC Pilfered Goods 5 5 gold 10 Any consumable 15 A shield, or accessory 20 Main Weopon

Historical Calling The Calling of Ornn “I have said enough.” ~ Ornn Ornn, the fire below the mountain, is the Freljordian demi-god of forging and craftsmanship. He works in the solitude of a massive smithy, hammered out from the lava caverns beneath the volcano Hearth-Home. There he stokes bubbling cauldrons of molten rock to purify ores and fashion items of unsurpassed quality. When other deities—especially Volibear—walk the earth and meddle in mortal affairs, Ornn arises toof Anivia ''I am the fury of the blizzard, the bite of the wind, and the cold of the ice. I am the Freljord.'' ~ Anivia Anivia, the cryophoenix, is a being of the coldest winter, a mystical embodiment of ice magic, and an ancient protector of the Freljord. She commands all the power and fury of the land itself, calling the snow and bitter wind to defend her home from those who would harm it. A benevolent but mysterious creature, Anivia is eternally bound to keep vigil over the Freljord through life, death, and rebirth. The Calling of Anivia Spells blacksmith level Spells 1st Feather Fall, Ice Knife 3rd Aid, Sleet Storm 5th Beacon of Hope, Revivify 7th Elemental Bane, Ice Storm 9th Cone of Cold, Reincarnate