TNW Sites

BBC director general Mark Thompson has confirmed that the broadcaster is working on launching a service that will let users download individual TV programs for a fee, the Guardian reports.

Thompson made the announcement during a speech at the Royal Television Society (RTS) in London today. The rumor had first emerged last week that the BBC was working on this project, named ‘Project Barcelona’.

According to speculations, each episode could be priced at £1.89 (US$3) and it seems the platform would only offer purchases. As a matter of fact, TV episode rentals have proven disappointing, and Apple itself decided to drop them altogether last August.

Anticipating criticism, Thompson reportedly insisted that this project wasn’t a “second licence fee by stealth,” in a country where the annual license fee costs £145.50 }
}
public class Child1 : Base
{
  public Child1() : base(1)
  {
  }
}
public class Child2 : Base
{
  public Child2() : base(2)
  {
  }
}

@andreycha  - А лучше сделать свойство абстрактным.
public abstract class Base
{
  public abstract int ConstValue { get; }
}
public class Child1 : Base
{
  public override int ConstValue { get { return 1; } }
}
public class Child2 : Base
{
  public override int ConstValue { get { return 2; } }
}


+ 1)/2
Let x(a) be the second derivative of 7*a + 0 - 1/3*a**3 - 1/15*a**5 - 1/360*a**6 + 0*a**2 - 2/3*a**4. Let b(f) be the second derivative of x(f). Factor b(y).
-(y + 4)**2
Let c = 2/303 + 289/2121. Let g(q) be the second derivative of 0 + 4/7*q**3 + 8/7*q**2 + 2*q + c*q**4 + 1/70*q**5. Suppose g(i) = 0. What is i?
-2
Let u be (-5)/(-20) - (-4)/(32/30). Let c(w) = 3*w**2 + w + 2. Let r(f) = -9*f**2 - 4 + f - 1 - 4*f. Let i(o) = u*r(o) + 11*c(o). Factor i(a).
-(a + 1)*(3*a - 2)
Let a(c) = 7*c**2 + 3*c - 5. Let j(m) be the second derivative of m**4/12 - m**3/6 - m**2/2 + 21*m. Let g(t) = -a(t) + 5*j(t). Factor            Stock
catalogrule_rule                         Catalog Rule Product
catalogrule_product                      Catalog Product Rule
catalogsearch_fulltext                   Catalog Search

How does it work?

In short, Magento 2 creates triggers for each “Update by Schedule” index.
These triggers fire on any INSERT, UPDATE and DELETE on any of the entity’s tables.

On firing, they create a new entry with the entity id in a specific
changelog table.
When


is not possible via Magento’s admin panel, or that can be done faster via a direct SQL query with phpMyAdmin or with a script, this is still possible, even on a production webshop. Of course you need to have a good knowledge of Magento’s MySQL tables. But the partial reindexing techniques from Update by Schedule ensure that all necessary indexes and flat tables are updated, and even specific caches are invalidated.
References :

https://magento.stackexchange.com/questions/117030/what-is-mview-in-magento2
http://devdocs.magento.com/guides/v2.0/extension-dev-guide/indexing.html
https://www.bigbridge.nl/blog/essential-magento-2-partial-reindexing/
https://en.wikipedia.org/wiki/Materialized_view

Cascade Training Center provides official American Heart Association BLS for Healthcare Provider Courses. *Within 72 hours of successful course completion you will be issued an official AHA BLS Provider eCard by email.*

This official AHA BLS/CPR for Healthcare Providers course satisfies both the INITIAL and RENEWAL certification requirements. The BLS for Healthcare Providers Course teaches the skills of CPR for victims of all ages. The course is designed for healthcare providers working both in and out of hospital. The BLS course curriculum includes:

Assessment of Unconscious Victims

Adult Chest Compressions for Single and Multiple Rescuers

-Ventilation with a Pocket Mask

- Ventilation with Bag Valve Mask

- Ventilation with Supplemental Oxygen

Infant and Child CPR

- Infant and Child Chest Compressions

Treatment for Choking for all ages

Proper use of an Automated External Defibrillator (AED)

Textbook Policy:

The American Heart


Association requires each student to have access to their own current AHA BLS Provider Manual prior to, during and after the BLS / CPR course. If you do not have access to a Provider Manual, you MUST purchase one and will have the option to do so during your registration process. If the option to purchase a textbook is not available please contact the Training Center at (877) 277-6778 for further information. If you order a Provider Manual it will be provided on the day of class. Arrangements can be made for you to pick it up early if you prefer. Most classes include the option for shipping the Provider Manual. If you would like your textbook shipped to you before the course, please select the shipping optionus watching that video, we would naturally come to the conclusion that it didn’t get better. And, for most of us, it will be obvious that with Jamey gone, it will truly never get better for him on this earth because he’s not here on it.

But is it so obvious to other Lady Gaga fans? To other teenage, bullied, depressed, and hopeless Lady Gaga fans? A Lady Gaga fan who would kill for that kind of a shout-out, even if it is a posthumous one? The LGBT Movement Advancement Project, a joint effort of the American Foundation for Suicide Prevention, GLSEN, GLAAD and others, have a very informative 12-point guide for talking about suicide (PDF: 642KB/4 pages). Points 7 and 8 are particularly relevant here:

ï»¿ï»¿ï»¿7. DON’T normalize suicide


and laughing at you like your not there. You find out the truth about people.

The problem with this exaggerated fear that somehow Lady Gaga mourning the death of a fan will somehow “glamorize” suicide is that it victimizes Jamey all over again.

As to Matt, who claims that my being tired of gay people attacking each other is equivalent to being in favor of group think: learn how to read. I am not advocating group think, but I deplore our tendency to turn on each other and our allies. We have enough enemies who are happy to attack us; why aid them. I am sure that somewhere some rightwing asshole is writing about how gay people agree with them that Lady Gaga’s “glorification” of Jamey’s death is the realin the final analysis, I don’t care one way or another about Lady Gaga’s feelings. She’s an adult whose able to take care of herself. My concerns are 100% with other kids who are being bullied and victimized and whose mental state leads them to take illogical and self-destructive acts. As Bose in St. Peter MN put it so very well:

The decision to die isnâ€™t the product of a healthy brain doing a cost-benefit analysis. Death is generally preceded by some combination of irrational thinking, severe despair, anxiety, depression and/or other mental illness.

Having been through various aspects of that experience myself when I was younger, that’s the kid I care about today. This isn’t about making you or Lady Gaga feeling vindicated because a kid killed himself. It’s


about youth. Evidence suggests that, as a group, kids who have died by suicide have had high rates of mental health issues, interfering with their ability to think rationally while making life-or-death decisions.

Thank you for your response above to my posting re Lady Gaga’s public mourning of Jamey Rodemeyer. I think what she did was admirable and perhaps necessary. But I also see your point as well, especially as you have explained it more fully. I apologize for the snark. I know that your motivations are entirely positive and I admire your work deeply.

Jim said “There are many ways to mourn, even publicly. Making someone a star for killing themselves is not appropriate.”.

I see your point, but on the other hand I don’t think its appropriate to tellanyone how to mourn. You can’t blame Lady Gaga for doing it her own way anymore than you’d tell a person at his funeral they shouldn’t be there because they’re making a scene.

Jim said “If we want to perpetuate the cycle of torment and death, then the best way to do it is to do exactly what we are doing now: by reinforcing the assumption that suicide is a logical consequence of the kinds of bullying and rejection, that virtually all of us have experienced.”.

I don’t see where Lady Gaga’s act did that. Just because someone mourns publicly it doesn’t mean they think or are saying suicide is a logical consequence of bullying. If someone interprets it that way, that’s their mistake, not Lady Gaga’s.

Seriously? These two “Don’t”s


big-picture questions Jim is asking aren’t so much trying to chastise Lady Gaga as they are challenging all of us to reflect on our public responses to youth suicide may or may not be helping vulnerable surviving youth. He was just as hard on himself and past coverage at BTB as Gaga.

Let me take a stab at re-framing this a bit.

The loss of a single young person who was struggling with bullying is heartwrenching, a stab to the gut. It’s only humane to mourn, to feel desperate to do something meaningful and immediate. Everyone, from online writers, to non-profit groups, to celebrities, to health care providers, feels the urge to do something which will (a) mourn the loss, and (b) help to prevent the next suicide.

The first —am struggling with you. If you are hurting, I am hurting, too. Call the Trevor Project. Talk to somebody. Do whatever you have to, but stay with me. It could be an appeal for donations to the Trevor Project, or for fans to check in with vulnerable loved ones to say, how can I help and you matter to me.

There are countless, very individual ways that all of us could frame our public messages to encourage prevention, and some simple guidelines for avoiding the opposite. I’m not trying to censor anyone, but I trust that people who care as deeply as Gaga want to know the difference between what helps and what hurts.

In this original BTB Investigation, we unveil the tragic story of Kirk Murphy, a four-year-old boy


an average of eight additional partners per year outside of their steady relationship. In this report, we will take you step by step into the study to see whether the claims are true.

Tony Perkins’ Family Research Council submitted an Amicus Brief to the Maryland Court of Appeals as that court prepared to consider the issue of gay marriage. We examine just one small section of that brief to reveal the junk science and fraudulent claims of the Family “Research” Council.

The FBI’s annual Hate Crime Statistics aren’t as complete as they ought to be, and their report for 2004 was no exception. In fact, their most recent report has quite a few glaring holes. Holes big enough for Daniel Fetty to fall through.my thumb which was at quite a weird angle and therefore needed the little “brush wand” to help it along the way. I don’t think it’s just my thumb, for the record. I think all thumbs will struggle with this type of remover pot. Also, I took one for the team and attempted to remove my pedicure with this; it’s not easy, I wouldn’t recommend. I think that’s what the wand is for.

I haven’t tried other brands so I don’t know how this stacks up to others, but I can definitely recommend this one. Give it a go next time you’re at Ulta, and if you are at another store and they have “their” brand, try it out!

Let me know if there is one in particular that is


transfected with G9a-mVenus, while the signal was highly restricted to mCherry-positive cells in hCdt1(1/100)-G9a-mVenus-transfected cells (Fig. [4b](#Fig4){ref-type="fig"} right panels). On the other hand, mVenus signals in hGem(1/110)-G9a-mVenus-transfected cells were detected from middle of the G1 phase to the M phase, as seen in Fig. [4b](#Fig4){ref-type="fig"} (2^nd^ bottom right panel). We further performed live fluorescent imaging and quantified the intensity of fluorescence signals using MetaMorph (Fig. [4c,d](#Fig4){ref-type="fig"}). The mVenus signals for hCdt1(1/100)-G9a-mVenus appeared and disappeared at almost the same time as the mCherry signals (Fig. [4d](#Fig4){ref-type="fig"} bottom right panel). On the other hand, the mVenus signals for hGem(1/110)-G9a-mVenus appeared before the shut-down of the mCherry signals (Fig. [4d](#Fig4){ref-type="fig"} upper right panel), and were detected until the end of the M phase when AmCyan signals disappeared (Fig. [4d](#Fig4){ref-type="fig"} upper middle panel). Furthermore, we examined the expressiondivision^[@CR6]^. It is conceivable that this recovery is mediated by G9a, since G9a is the typically major enzyme for H3K9me2. However, there is not yet direct proof for this. Furthermore, it is unclear whether H3K9me2 is also catalyzed in the G1 phase. Presently, using cells that expressed G9a only during the G1 or out-of-early G1 phase, we found that G9a can induce H3K9me2 in not only S/G2/M phases but also in G1 phase of the cell cycle. These findings are crucial for the development of disease treatment approaches based on epigenome-manipulation. The demonstration of H3K9me2 recovery specific in G1 is especially important, because the long-lived, terminally-differentiated cells in the human body, such as neurons, are mostly post-mitotic G0-G1 cell populations.

Materials and Methods {#Sec6}
=====================

Construction of Fucci vectors {#Sec7}
-----------------------------

tFucci(SCA)2.1 was


MELBOURNE researchers have discovered how milk is digested, paving the way for the development of vitamin-loaded milk for premature babies, weight-loss drinks, or new drug delivery systems.

Little has been understood about milk’s molecular structure and how its fats interact with the digestive system.

Monash Institute of Pharmaceutical Sciences research fellow Dr Stefan Salentinig found that milk’s unique structure, an emulsion of fats, nutrients and water that don’t usually combine, enhances its digestibility.

His team chemically recreated the digestive system in a glass beaker and added cow’s milk, analysing the real-time digestive process with the Small Angle X-ray Scattering beam line at the Australian Synchrotron.

Instead of joining as large fat masses, they found that milk arranged itself in a highly-ordered structure, which helped the protein lipase absorb milk’s healthy fats intoTT Silent

Flow rate: 1050 m3 / h or 1330 m3 / h. ONE option to capture the external temperature, a probe 4 m long is attached to the extractor.

This extractor SILENT TT-M 250mm Winflex allows you to renew the air in your grow room. The extractor, renews CO² and ejects air depleted of the culture chamber while regulating T °. Most of this extractor is that the fan is located within an insulated housing acoustically. This extractor is designed to be silent. The air is still powerful and high pressure. Features SILENT extractor TT-M Ø 250mm A R1 with IEC: Ø air outlet: 250 mm Equipped with a temperature module and an electronic speed...

Flow rate: 1530 m3 / h or 1950 m3 / h. The UN option is


1300s and 1600s. Grevel House, established in 1380, is the town’s oldest building. Admire the 17th-century Market Hall, built as a shelter for passing traders. The Town Hall was previously a court house, jail and wool exchange.

Several old buildings now double as shops of local businesses. Find everything from artisanal food to an independent shoemaker, jeweler and potter. Take a break at cozy teahouses and sample the hospitality of a traditional pub. The Eight Bells Inn has been welcoming guests since the 1300s.

Spot impressive stained-glass windows at St. Catherine’s Roman Catholic Church. See work by an artist cooperative at the Gallery at the Guild, housed in the Old Silk Mill. Relax amid colorful plants in Ernest Wilson Memorial Garden.

Discover the stunning natural landscapes of the Cotswold countryside viaResearch Complex, the UST Tan Yan Kee Student Centre, and the recently-built, 12-Floor Buenaventura Garcia Paredes, O.P. Building (UST Alumni Center) which houses students from the Faculty of Arts and Letters and the College of Tourism and Hospitality Management.

The streets of the University were non-existent until March 1960. The prominent university streets are Intramuros Drive, Quezon Drive, and Osmeña Drive.

The UST Manila campus was declared a National Historical Landmark by the National Historical Commission of the Philippines on 24 May 2011. Four of the University's structures are also declared National Cultural Treasures by the National Museum: Main Building, Arch of the Centuries, Santissimo Rosario Central Seminary, as well as the Grandstand and the University field. UST is the first and only university campus to have been named a


located at the St. Martin de Porres building, while the Faculty of Pharmacy is located at the Main Building.

The Faculty of Philosophy and Letters was founded in 1896. It was merged with some programs of the College of Liberal Arts in 1965 hence renaming the Faculty of Philosophy and Letters as the Faculty of Arts and Letters (the College of Liberal Arts was renamed the College of Science). The Faculty of Arts and Letters offers the Bachelor of Arts (AB) degrees in Asian Studies, Behavioral Science, Communication, Economics, English Language Studies, History, Journalism, Legal Management, Literature, Creative Writing, Philosophy, Political Science, and Sociology. The Faculty of Arts and Letters is located in the St. Raymond de Peñafort building. Its students are known as "Artlets" (previously "Philets"). The Journalism,shall face “non-readmission, exclusion or expulsion”.

In August 7, 2018, in defiance against the school administration, the university's Catholic student council launched a collective statement with fellow Catholic student councils from Ateneo de Manila University, De La Salle University, De La Salle–College of Saint Benilde, Miriam College, St. Scholastica's College, Manila and San Beda University, calling on the Senate of the Philippines to enact the pro-LGBT SOGIE Equality Bill into law. The move marked the first ever inter-school Catholic-based LGBT support system in Philippine history.

Notable people
Alumni

Persons affiliated to the university, either as students, faculty members, or administrators, are known as "Thomasians".
José Rizal (National Hero of the Philippines), studied Medicine at UST, and continued it at the University of Madrid in Madrid, Spain. The University has produced four Presidents of


I am sure you have observed that puzzle number 34 (exponentiation, page 64), A3E4, is indicating (below) 10x10 puzzle, while it's a 9x9.And puzzle number 109 (variations, page 156), A3V9, is indicating 8x8 puzzle, while it's a 6x6, so you have small corrections for the next edition .

It's a very advanced book, wonderful, some puzzles are really difficult.

I am sure you have observed that puzzle number 34 (exponentiation, page 64), A3E4, is indicating (below) 10x10 puzzle, while it's a 9x9.And puzzle number 109 (variations, page 156), A3V9, is indicating 8x8 puzzle, while it's a 6x6, so you have small corrections for the next edition

Argh, those slipped through, even after a "manual" check of each puzzle

Thanks for pointing this out.

clm wrote:

It's a very advanced book, wonderful, some puzzles are/**

\page org_mitk_views_igtregistrationview The IGT Registration view

\imageMacro{iconTrackingRegistration.png,"Icon of the MITK-IGT Fiducial Registration",2.00}

\tableofcontents

\section QmitkMITKIGTTracking_RegistrationIntroduction Introduction

The MITK-IGT Fiducial Registration is a view which allows you to record real world landmarks as well as the corresponding landmarks on a virtual object with a tracking pointer of your choice.

\imageMacro{QmitkIGTTracking_RegistrationView.png,"Screenshot of the MITK-IGT Fiducial Registration View",2.00}

\section QmitkMITKIGTTracking_RegistrationPreliminaries Preliminaries

First connect your tracking device to your PC. Then start the MITK Workbench and configure your tracking device using the \ref org_mitk_views_igttrackingtoolbox.

\section QmitkMITKIGTTracking_RegistrationConfiguration Configuration

First of all you have to choose which tracking pointer should be used by clicking on one of the listed Available Navigation Data Sources and one of its related Tools. Confirm the tool to be used by clicking on Choose Selected. Above, the Polaris was chosen as navigation data source. In this case it


has only one tool, the NDIPointer, which was selected as tracking pointer.

In case you want to select landmarks on a virtual object, you have to load the image or surface and confirm by clicking Choose Selected.

\section QmitkMITKIGTTracking_RegistrationPointRegistration Point Based Registration

Now select the landmarks in the real world using the pointer: Press the plus button in the Tracker fiducials column and point to the landmarks in the real world. Press Add current instrument position to tell the MITK this is the desired landmark.

To select landmarks on the virtual object or image, press the plus button in the Image/object fiducials column. Add landmarks by pressing Shift and clicking on the desired position of the virtual object or image. Make sure to select the landmarks on the virtual object or imageblew up, unleashing the era of the Fed market put.

Which is probably why the OFR ends on a positive note: in its conclusion, the watchdog said that when it weighed the financial system’s resilience against its vulnerabilities, "overall risks to stability remain in the medium range."

Which means that no action will be taken, and that investor leverage will continue to rise, and volatility keep falling, until the next "large correction" forces a sharp, quick reset.

Source: 2017 Financial Stability Report


patients with FDG-avid nodal disease at baseline. [Table 2](#t2-10.1177_1179554917713005){ref-type="table"} demonstrates the sensitivity, specificity, PPV, and NPV for the response assessment FDG PET-CT outcomes for primary tumour alone and lymph node involvement alone (positive and equivocal responses are grouped together for the purposes of this analysis). Where primary tumour or lymph nodes were not assessable on the baseline FDG PET-CT, these were omitted from the analysis of the respective response assessments. In the overall cohort, 2-year PFS and OS were 63% and 67%, respectively. [Figure 2](#f2-10.1177_1179554917713005){ref-type="fig"} demonstrates PFS and OS outcomes comparing groups with a complete metabolic response, equivocal FDG uptake, or persistent FDG uptake suggestive of residual disease. A complete metabolic response was associated with superior PFS (log-rank test *P* = .01), although the association with OS wasSUV in the positive FDG PET-CT group for nodal site was 5 (range, 2.9--11.5). [Table 4](#t4-10.1177_1179554917713005){ref-type="table"} shows outcomes of equivocal and positive FDG PET-CT reassessments. All 5 of the patients with a positive scan were classified as true positives (PPV 100%), whereas the equivocal response scan was a false positive. One (5%) of the 20 patients with a negative response assessment FDG PET-CT developed nodal recurrence, with an NPV of 95%. This patient was treated with chemoradiotherapy for a T4N2c laryngeal squamous cell carcinoma.

Detection of distant metastases by FDG PET-CT
---------------------------------------------

Three of 35 patients had distant metastatic disease detected on response assessment FDG PET-CT. In all 3 cases, the patients had developed pulmonary metastases. In each of these patients, the finding of distant metastatic disease was not biopsy proven


portfolios comprise at least two currency portfolios each investing in a different currency.

4. The financial network of claim 3 wherein said transaction instruction is a transfer of shares between different shareholders in two different portfolios.

5. The financial network of claim 4 further comprising means at shareholder workstations to initiate a transaction instruction initiated by each of two shareholders for a matched transfer of shares whereby shares in one of (n) currency portfolios are transferred from a one shareholder to a second shareholder while simultaneously shares in another of (n) currency portfolios are transferred from said second shareholder to said first shareholder, based on an agreement between said shareholders negotiated outside of the financial network.

6. The network of claim 3 further comprising means at a shareholder workstation for enteringwhile simultaneously transferring a specified number of Yen shares from the other to the first shareholder. This share transfer mechanism is also useful for the transfer of value as represented by otherwise non-convertible currencies.

Within the mechanism a shareholder may also move funds from one portfolio to another by redeeming shares in one portfolio and using the proceeds to fund a traditional foreign exchange transaction in which he obtains the currency of the second portfolio, and then, using the second currency purchases shares in the second portfolio.

Access to the financial network would be, generally, a workstation with dedicated software to provide access into a client service and administration system. The financial network also includes a bulletin board feature whereby shareholders can list expressions of interest to "swap" shares with


a denominated currency and additionally, movement between currencies by portfolio exchange and by matched transfers. The latter is equivalent to a foreign exchange transaction.

This invention will be described in greater detail by referring to the attached drawing and the description of the preferred embodiment that follows.

BRIEF-DESCRIPTION OF THE DRAWING

FIGS. 1A and 1B are flow charts illustrating the system components of the financial transaction network in accordance with this invention;

FIG. 2 is a flow chart illustrating the transaction flow for a share purchase;

FIG. 3 is a flow chart indicating the transaction flow for a share purchase and transfer:

FIG. 4 is a flow chart illustrating the transactional flow for a matched share transfer:

FIG. 5 is a flow chart illustrating the transactional sequence for a share receive and redeem transaction: and

FIGS.For all transactions, the CSA will review the instruction received from the shareholder 100 and check for syntax error and content validity. For some transactions, the CSA system 110 will also check for a sufficient share balance by inquiry to the database 112 or to determine whether the transaction is timely, as in the case of expedited transactions. If for any reason the instruction is not valid, it will be rejected and the CSA 110 will issue an appropriate error message to the shareholder workstation. An audit trail of all rejected messages will be sent to the electronic mailbox for each shareholder who was party to the transaction.

Once an instruction has been received and validated, the CSA 110 will assign a transaction number to that instruction. This transaction


number generated by the system is separate from the client reference number. The instruction will then be time-stamped and tagged that it has been accepted. Validation of an accepted instruction will be sent to the shareholder workstation 100, thus indicating to the subscriber that the transaction has been accepted for entry into the system. Once approved by the CSA, the transaction will be time-stamped and tagged, then either transmitted to the Transfer Agent system 114 as in the case of transfers, or put in a pending queue, as in the case of purchases and redemptions.

At the same time, a communication link is utilized between the CSA 110 and the appropriate Custodian 116 for purposes of providing instructions to the Custodian to receive funds or securities, in the case(block 20), and if funds are not received by a specified period, a message is automatically sent to the customer mailbox indicating non-receipt of funds. If money is not received within a further specified period from receipt of the instruction, it is automatically deleted and a message is sent to the customer mailbox indicating the action.

If sufficient funds are received by the Custodian, the approved transactions are released to the Transfer Agent, (block 21). Then, the Transfer Agent will issue the shares to the shareholder account at block 22. Block 23 in FIG. 3 is the transfer function. In the case of this instruction, the Transfer Agent, having issued the appropriate number of shares, will then transfer the requested shares to the account of the designated recipient. Information


matched transfer can post information with respect to desired exchanges utilizing the electronic bulletin board 124 which is maintained 24 hours a day. A shareholder at workstation 100 can scan the bulletin board 124 to determine whether there are potential buyers or sellers in the portfolios of interest. Upon finding a potential counterparty (another shareholder to exchange with), the shareholders negotiate the terms of the transaction outside of the financial network by phone, facsimile transmission or other external means.

Once the terms of the matched transfer are agreed upon, both parties must select a matched transfer instruction from the main menu at workstation 100, enter required account information, the party with whom they will do a transfer (the counterparty), the desired portfolios, and the agreed upon number of shareswere burning in parts of Sweden Wednesday, the Local Sweden reported, prompting evacuations in the Swedish counties of Dalarna, Gävleborg and Jämtland.

A pair of Italian planes and eight Norwegian helicopters were assisting firefighting efforts, and Sweden's Civil Contingencies Agency requested more aerial assistance from the European Union in what they told the Local Sweden was the nation's most serious wildfire situation of modern times.

This is happening during a heat wave that is smashing some all-time records across parts of Scandinavia.

Kvikkjokk, a village in northern Sweden just north of the Arctic Circle, topped out at 32.5 degrees Celsius, just above 90 degrees Fahrenheit, setting their all-time record high, according to climatologist and world records expert Maximiliano Hererra .

<img class="styles__noscript__2rw2y" src="https://s.w-x.co/t-anomalies-scandinavia-heat-18jul18-cci.jpg" srcset="https://s.w-x.co/t-anomalies-scandinavia-heat-18jul18-cci.jpg 400w, https://s.w-x.co/t-anomalies-scandinavia-heat-18jul18-cci.jpg 800w" > Global Forecast System (GFS)


south than Utqiagvik, Alaska (formerly Barrow) – topped 86 degrees.

According to Hererra, all-time record highs have been set in 14 locations in Norway, 10 locations in Finland and three locations in Sweden.

<img class="styles__noscript__2rw2y" src="https://s.w-x.co/europe-heat-dome-500mb-1may-16jul18-ncar.jpg" srcset="https://s.w-x.co/europe-heat-dome-500mb-1may-16jul18-ncar.jpg 400w, https://s.w-x.co/europe-heat-dome-500mb-1may-16jul18-ncar.jpg 800w" > Anomalies in upper-level 500mb heights from May 1 through July 16, 2018, illustrating the persistent upper-level high-pressure system (darker orange/red colors) over northern Europe, responsible for the persistent hot, dry weather.

Hot, Dry Since May

This heat wave is just the latest episode of what's been an exceptionally hot, dry late spring and summer so far in northern Europe.

Since May, an expansive high-pressure ridge aloft has stretched across most of northern Europe, from Ireland and the U.K. to Scandinavia.

This blocking high has diverted rain well south over southern Europe, and itsQ:

What is the most common English term for a person who attempts a coup d'état?

In Latin America, we have the Portuguese/Spanish word golpista (from the word golpe = coup d'état). In the British media, I've read coup monger and also putschist (from German word putsch = coup d'état).
But are these expressions as common in English as golpista is for Latin Americans?

A:

There is no specific English agent noun for the leader or participants in the modern sense of a coup d'état, at least in common usage.
You will usually find coup coupled with a generic term for a leader. In fact, coup leader has the most results in COCA and the BNC among all my searches. Coup organizer is roughly equivalent though much less common. In headlines or in less


with a diagnosis of Parkinson's disease in private office, hospital-based, and VA clinics. He has established local and regional support groups, comprehensive rehabilitation programs, and a privately funded resource center for patients that also serves as a source of pilot funding for Parkinson's-related research. As investigator and coordinator members of the Parkinson Study Group (PSG), the PI and this study's designated nurse coordinator are currently participating in a PSG sponsored trial of a medication for early, untreated, Parkinson's disease. Eleven patients were randomized for this study in under 16 months; all of these patients have remained in this study (last patient enrolled 1/04), with strict protocol adherence maintained. The PI is currently participating in an additional double-blind study for more advanced patients, and in an open-label study ofalmost five o'clock.

I was captivated, inspired and surprised. He lived up to the hype and more. I didn't want his presentation to end. His vocal cadence was charismatic and pleasing to the ear. His passion, demonstrated by a range of facial expressions and gestures was nothing short of oratorical brilliance.

Dr. Johnson looked at his watch and solicited questions from the class.

"Sir. Gunnery Sergeant Patterson, from the First Surveillance Reconnaissance and Intelligence Group. Could you tell the class what was the lowest point of your thirty-five-year career?"

Dr. Johnson stroked his salt and pepper mustache as he contemplated an answer.

"Hmm. I have had many tough challenges in my career; however, June 8th, 1980 comes to mind. On that day, I was arrested in Minsk, Belarus in my hotel room around


daily and always chased me home from school, until one day I spoke with my Dad. He reiterated that although he was against fighting in school, he was all about defending yourself. That conversation over dinner literally gave me an enlightened perspective. The next day I went to school, I didn't run home after the bell. I waited for Antonio instead."

'So what happened?" Crocket asked.

"You see, bullies usually are not very bright and they are predictable because they work off a script.

"He approached me with his buddies cracking his knuckles and he was surprised I didn't run away like I always had. He spit in my face and called me a name in front of everyone. They all laughed as I wiped his spit of my face. Iunder Islam.

"The rights of Muslim women are given to us by Allah, who is all-merciful, all-knowing and all-wise. Islam considers women equal to men as human beings. That is what the Holy Quran states," Ayan said vehemently as she stared at the midnight starry sky.

I had no real understanding of Islam but I found the passion in her conversation non-threatening to my Christian beliefs and even intriguing.

As we walked along the perimeter of the compound, it almost felt like she was trying to groom me for Muslimhood. I felt a desire to respond with a few tenets of my own faith.

'Vengeance is mine sayeth the Lord'. That is one of my favorite quotes from the Bible. By letting God deal with my adversaries, it prevents me from harboring


Ayan undressing and then I turned toward the sheets that divided the room. The dim light in the room projected the silhouette of her unclothed womanly body onto the sheet. The image of her perfectly shaped body burned itself into the depths of my subconscious. I wanted to rip the sheets down and ravish her body over and over again. In my mind's eye that's exactly what I did. I soon nodded off to sleep.

### Chapter 11

Counterintelligence Was Here

22 February 1993

I slept like a baby. I dreamt about Ayan and the things we did in my dream would be expressed only in my journal. I woke up about ten minutes before the alarm and the only thing on my mind at the time was "Did I snore?"

I wasdirection.

"So where did you two disappear to last night?" I asked Eric as I put my helmet on.

"Tootie took me to her duty section. They don't pull twenty-four shifts, so we had the office all to ourselves. So how did you and Ayan get on, you guys had the room all to yourself," Eric asked as he started up the engine.

"Still in first gear, but the revs are climbing," I said unashamedly.

"So. If I can get the vehicle again tonight, you wanna come along?" Eric asked me.

"Hmmm...let me think about it for a second. Are you insane?" I replied as I rolled my eyes in his direction.

"Just get me off the base, that's all I can think about right now."

"Relax, no one is gonna get in trouble. We


base in the Philippines. ARFCOS was a distribution center for highly classified material and its packages were not subjected to custom inspections. All the packages were received by the unit Classified Material Control Center (CMCC). When I reported into the unit, I immediately heard of two Marines who fled the island and never returned. One of the Marines was named Whittaker. Whitaker and his co-worker worked in the CMCC and took off with some drugs and cash. The S-3 decided to replace the two deserters with Marines who were drug-free to minimize the risk of a repeated incident. The company had an _unofficia_ l urinalysis test to see who was clean. Over 85% of the troops in our unit popped on something. I got tapped for a CMCCsaid as he placed his hand on my shoulder with a grin.

"Sure. What would that be?"

"Counterintelligence is one word, not two."

"I thought so. I wasn't sure. That's an easy fix."

I was pleased that my report was well received despite using the wrong report format.

"Gunny, I spoke with the Team Commander, Major Haycock, about you and we would like to formally introduce you to the Team. If you're not committed right now, follow me downstairs.

I followed Pritchard down two flights of stairs into the basement of the Headquarters building. The elevators were not functional and had yellow tape in the figure of a large X across the doors.

We proceeded down a long corridor that had two armed sentries posted by a door at the end of the hallway. Pritchard


defenses lower and received a very positive vibe.

"I also am an expert in assessing body language to interpret a subject's emotions and thought processes."

"Would you be able to tell if someone was lying to you?" I asked.

"After I established a baseline, most definitely. There are certain data points that a polygraph is unable to register. That is where I come in. I often will work with a polygrapher."

"Wow. That sounds like a skill that could be very useful in your personal life. Where do I sign up?" I asked semi seriously.

Lieutenant Stein really impressed me and I could have listened to him all day. He wasn't the kind of guy I would invite to a house party, but he struck me as someone who I could easily talkSullivan's wife being in a car crash last night. She's on life support and things don't look good. I asked Major Lewis to sign off on Emergency Leave papers and he wanted to know specific details before he would sign the papers. What is his deal? I went straight to the Chaplain and got it approved. Major Lewis can kiss my White ass," Eric said angrily.

"Damn. Is there anything I can do to help?" I asked.

"Don't think so. There is a plane leaving for the States in about two hours; gotta get him on that bird."

I looked at Sullivan and he was shell-shocked. I offered my condolences.

"Alright then. Hey Sullivan, I'm praying for you, man."

Sullivan didn't even acknowledge me, he was almost catatonic, completely unresponsive.

"Hey Eric. Check you


of my misery.

By then frustration was felt among all the board members and they stopped taking notes. I was hoping they would just stop the board. It was obvious that I was way off my game. But Pritchard pressed me for another question.

"Gunnery Sergeant Thompson. What is the Sixth Counterintelligence team motto?"

"Uhmm, uhmm. Detect, deny and...conceive."

By that time I had completely checked out mentally and I was having an out-of -body experience.

Pritchard whispered something to Major Haycock and then he addressed me.

"Gunnery Sergeant Thompson. I really don't know what your major malfunction is, but I am recommending we have a recess, especially after that last response. Do you think you can get your shit together by let's say 1330?"

I took a very deep breath of relief. No moreboard."

"Not much to say. They want me to come back after lunch but that's a negative. I'm done with it. Stage fright got the best of me and that's not like me at all."

My last comment provoked an interesting discussion that gave me some insight.

"Let's call it like it is. Stage fright or fear of public speaking are misnomers. I would define it as fear of rejection or fear of failure. No one is fearful of speaking."

"I'm a confident person...I just lost it," I commented.

Dr. Gaye sat back in his chair and I could tell he was in deep thought. My dad had that same look when he weighed his thoughts.

"Confidence is one thing and harnessing it is another. Are you feeling adventurous? Because I have a dare


and I had twenty minutes before my interview. I was remotivated. We both stood and stretched and I gave him a bro hug. Dr. Gaye once again helped me and somehow a handshake didn't seem to adequately reflect my appreciation. Game on.

### Chapter 22

Anatomy of an Interview Part II

27 February 1993

Twenty seconds? Let's do this.

"Sir, Gunnery Sergeant Thompson reporting as ordered, sir!"

I noticed Major Haycock was not present, but his absence took some of the pressure off. Gator, Stein and Pritchard presided over the board. Pritchard sat in the middle, Gator was to his left and Stein to his right.

Pritchard kicked it off as soon as I was seated.

"Gunnery Sergeant Thompson, why should we accept your application for counterintelligence training?"

"Master Gunnery Sergeant Pritchard. You should accept me becausewas Private First Class Domingo Arroyo Jr., a United States Marine. Arroyo was the first Puerto Rican and American serviceman to be killed in Operation Restore Hope, the first of forty-four to sacrifice their lives during the humanitarian campaign. The Marines of the 1st Marine Division honored Arroyo by naming their camp and a nearby beach in his honor; Camp Arroyo and Arroyo Beach.

Private First Class Domingo Arroyo Jr

(March 7, 1971 – January 13, 1993)

### Chapter 24

Twenty Seconds of Restraint

27 February 1993

As we proceeded thru the gates of our compound, I asked Master Guns if he could drop me off in front of MARFOR where I worked. I surrendered the shotgun I was issued for the mission and had a few parting words.

"Master Guns, thank you for letting


with relief. That exchange was truly uncomfortable and agonizing. As I stood outside his door, I opened the folder and looked at the last page where he signed.

_Not Recommended. S_ igned Major T.W. Lewis.

### Chapter 25

High Risk Counseling

27 February 1993

I left Major Lewis' office just like every other time in the past: majorly pissed off. He knew what buttons to press to get inside my head and he did so at his own risk.

Reprimanding someone with a loaded firearm had its challenges. It didn't take very long before some officers and senior noncommissioned officers figured out how to negotiate this dilemma. The trick most leaders I knew used was to concoct a story about why the wayward Marine needed to surrender his weapon. The line I heard mostdid before the CI interview initially. But Gator was on his game and he made the brief interesting and even used a bit a wit. He did an excellent job and I developed a professional respect for him, despite our history. At the end of his briefing, he easily answered all of our questions, except the questions raised by Major Lewis. Initially, Gator was able to fend off the first round of questions from Major Lewis. But Major Lewis broke what I call the "three-question rule" by continuing to press Gator into answering questions that were obviously too sensitive to discuss in an open forum.

Major Lewis wanted to have the last word.

"There is no place in our military for criminals such as saboteurs or spies. That is why


answers and I was begging her. She looked around to see if anyone was watching, which I thought was odd.

"Clay, follow me to the recreation center and we will talk there."

When we arrived, there were just a few Airmen milling around in the library. Tootie sat down in a chair and asked me to sit beside her.

"Clay. It's not what you have said or done."

"Then what is it then? Just tell me, I can handle it." "It's what you wrote."

"What are you talking about?" I asked.

"It's your diary. She accidently collected it after the picnic and..."

I immediately searched my left cargo pocket where

I normally would keep it. It was gone. "Did she read it?"

"Yes."

"All of it?" I asked.

"I don't know, but enough to upset her."

I logged a journalmade me endure, I was more than happy to forgive and maybe forget.

"Are you ready to begin typing?"

"Ready when you are, Major," I replied, poised to begin typing.

"For meritorious service as the Logistic Chief for MARFOR, Gunnery Sergeant Eric Sherman displayed...blah, blah, blah."

I was naïve and stupid to think a leopard would ever change its spots. I couldn't let him know how deep the cut was so I continued to type as if nothing had fazed me. I handed him the write up and smiled. I walked away angry. In my mind's eye, I was causing him great bodily harm and I enjoyed it. I decided to do an inventory of classified, just as busy work to keep from snapping over that last dig.

I was half way through


the coin. "Legion of Merit, so it is."

I was designated videographer, but I wanted to be in the film when my name was called.

"Major Lewis, what should I do with the video camera when they call my name?" I asked as I placed the lens cap on the camcorder.

"Gunnery Sergeant Thompson, they are not going to call your name. That is why I designated you videographer."

Of course not. I was naïve to expect anything from Major Lewis. I took it personally and was offended, but I remained silent. To argue for an award would be a losing argument. Major Lewis relished the idea of being in the spotlight. Recognition of those who helped get him there was an afterthought.

The awards formation was held on the General's lawn infield $\sigma$. Due to the scale transformation, there is a difference in time interval between the Einstein and Jordan frames. Of course, we usually use clock to measure time. The clock could be based essentially on electromagnetism. In the Jordan frame, where the scalar field $\sigma$ does not couple with matter, especially with electromagnetic fields, the time measured by the clock is proportional to the cosmological time in the FRW metric. On the other hand, in the Einstein frame where the scalar field $\sigma$ couples with matter, the time measured by the clock is not always proportional to the cosmological time, due to the coupling of the scalar field $\sigma$ with electromagnetic field. The difference, of course, comes from the factor of the scale transformation, which includes the


scalar field $\sigma$. Since $\sigma$ is time-dependent in general, the time measured by the clock becomes, say, slower than the cosmological time in the Einstein frame. It is estimated the acceleration of the universe started about five billion years ago. The five billion years are measured by using the electromagnetism. Hence, these five billion years could be identified with five billion years in the Jordan frame but not with those in the Einstein frame (for further discussion of the relation between Einstein and Jordan frames in cosmology, see review [@far]).

One may define the effective EoS parameter $w_{\rm eff}$ in Jordan frame as \[FRW3k\] w\_[eff]{}== -1 -  , The scale factor in Einstein frame (when the two frames appear) is denoted as $a(t)$. Note that if we dont makethe unacceptable force between distant Galaxies [@woodard]. As shown in [@SNPRD], however, by adding the positive power (higher than 1) of the scalar curvature to the action, the instability could be significally improved. Moreover, the account of quantum effects in modified gravity also acts against instability [@mpla].

It has been also mentioned in [@chiba] that $1/R$ model [@CDTT] which is equivalent to some scalar-tensor gravity is ruled out as realistic theory due to the constraints to such Brans-Dicke type theories. In [@SNPRD], it was shown that by adding the scalar curvature squared term to the action, the mass of the scalar field can be adjusted to be very large and the scalar field can decouple. Hence, the modified gravity theory of this section (after some fine-tuning [@SNPRD]) passes the


energy density $\rho$ behave as $E\sim a^{-3w}$ and $\rho\sim a^{-3\left(w + 1\right)}$. Thus, for the standard phantom with $w<-1$, the density becomes large with time and might generate the Big Rip. Hence, it is demonstrated that non-linear coupling of gravity with matter may produce the accelerated cosmology with the effective EoS parameter being close (above, equal or below) to $-1$. More complicated couplings [@coupled] may be considered in the same fashion.

Dynamical cosmological constant theory: an exact example \[S42\]
----------------------------------------------------------------

There are many proposals to solve the cosmological constant problem dynamically. One of the possible solutions of the cosmological constant problem is pointed out by Mukohyama and Randall [@MR] (see also [@Dolgov2]). In [@MR], the following action similar to the one under consideration has been proposed: $$\label{MR1}
I=\int d^4 x\sqrt{-g}\left[\frac{R}{2\kappa^2} + \alpha_0$h_0/t$ or $h_0/(t_s - t)$ for (\[mGB2\]) in sect.\[S2\], if we substitute the value of the age of the present universe $10^{10}$years$\sim
(10^{-33}$eV$)^{-1}$ into $t$ or $t_s-t$, the observed value of $H$ could be reproduced, which could explain the smallness of the effective cosmological constant $\Lambda\sim H^2$. Note that even if there is no potential term, that is, $V_0=0$, when $\beta<0$, there is a solution $$\label{MRIO13b}
h_0=-\frac{1}{3}<\frac{1-\sqrt{13}}{12}=-0.2171...\ ,$$ which gives the EoS parameter : $w=-3$, although $w$ is not realistic. Playing with different choices of the potential and non-linear coupling more realistic predictions may be obtained.

Hierarchy problem in modified gravity \[S43\]
---------------------------------------------

Hierarchy problem is known to be the fundamental one in high energy physics. It is interesting to understand if modified gravity approach may help in resolution of hierarchy problem? Recently


Since $\rho=f^{-1}\left(\kappa\sqrt{\rho/3}\right)$, we obtain the inhomogeneous equation of the state \[SN1\] p=-- f’(f\^[-1]{}()) . As an example, we consider the case \[SN2\] f=f\_0\^2 + f\_1 , with constant $f_0$ and $f_1$. Then (\[SN1\]) gives \[SN3\] 0=(p + )\^2 - f(1 - ) . If the matter contribution is neglected, from the first FRW equation, one finds \[kk2\] f\^2==H\^2 . Then we may rewrite (\[SN3\]) as \[kk3\] 0=(p + )\^2 - (1 - ) , which has a structure similar to (\[pH12\]). One may also consider the case that \[kkk1\] f= , which gives \[kkk2\] p=(-1 + ) . Then we obtain dark fluid with homogeneous EoS with $w=-1 +
{2}/{3f_0}$. Note that despite the fact that specific scalar-tensor theory and dark fluid may predict the same FRW dynamics, their physical properties may be different. For instance,Newton law, number of FRW solutions, their stability properties may significally differ in two formulations.

Another possibility to obtain the inhomogeneous EOS dark fluid is related with the modified gravity. As an illustrative example, the following action is considered: \[HD1b\] S=d\^4 x (R + [L]{}\_[matter]{} + f(R)) .

In the FRW universe, the gravitational equations are: \[HD2b\] 0&=& - H\^2 + - f(R=6H + 12 H\^2) && + 6(H + H\^2 - H ) f’(R=6H + 12 H\^2)  ,\
\[HD3b\] 0&=& (2H + 3H\^2) + p + f(R=6H + 12 H\^2) && + 2( - H - 3H\^2 + + 2H ) f’(R=6H + 12 H\^2) . Here $\rho$ and $p$ are the energy density and the pressure coming from ${\cal
L}_{\rm matter}$. They may satisfy the equation of state like $p=w\rho$. One may


modified gravity theory which, from one side, is as good as General Relativity in Solar System tests and from another side contains the fully consistent explanation for current cosmic acceleration. (Note that if universe is currently entering to phantom phase, then some deviations from General Relativity are quite expectable at large distances). It is quite possible that other versions of modified gravity: string-inspired gravity with fourth-order (or higher) in $R$ corrections, theories which contain Traces of inverse Riemann tensor [@ESTW] or negative powers of squared Riemann and Ricci tensors [@turner] or even non-local Riemann and Ricci tensor terms (for instance, of the sort induced by Quantum Field Theory [@eli] with terms like $R/R_{\mu\nu}\Box R^{\mu\nu}$, $R_{\mu\nu} R^{\mu\nu}/R\Box R$, etc) or some combination of the above models with the onesPresident Donald Trump is expected to soon nominate Rep. Tom Marino (R-PA) to be director of the Office of National Drug Control Policy (colloquially referred to as the “drug czar”).

Marino, a former prosecutor with no background in health or treatment, supports a punitive, 1980s style approach to drugs, including mass incarceration and coerced treatment - even for marijuana. Drug Policy Action, the political arm of the Drug Policy Alliance, gave him an “F” in their 2016 congressional voter guide.

He is a disastrous choice and must be opposed.

As a U.S. Attorney, Marino showed preferential treatment for a friend convicted of cocaine offenses, while showing little mercy for others caught up in the criminal justice system. In Congress, Marino voted against the Rohrabacher-Farr amendment, which prohibits the Department of Justice


from undermining state medical marijuana laws. He has called for “hospital-slash-prison” facilities where people caught possessing marijuana or other drugs would be forcibly detained.

Studies show that coerced treatment rarely works. Treatment works best when it is voluntary and meets the individual needs of the person struggling with substance-related issues. A Human Rights Watch report found that hospital-prison policies in China, Cambodia and other Southeast Asia countries led to enormous human rights violations. An evaluation by the Drug Policy Alliance of existing coercive drug courts in the U.S. found enormous problems with little positive impact. Combined with Attorney General Jeff Sessions’s support for executing drug traffickers the Trump Administration could move U.S. drug policy in horrific, un-American directions.

The nomination of Marino would represent yet another about-face by President Trump.stand. Despite Colin Kapernick not having a job...and the reason WHY...I am proud to be an American. Absolutely.

Miller then talks about a trip she took to Australia and the same-sex marriage debate that was occurring there (same-sex marriage passed in November 2017 in Australia) and how the next appointment of a Supreme Court Justice in the United States could take away her right to be married to whomever she wants.

The interim Lady Raiders basketball head coach then writes about how events in Charlottesville, Ferguson, and St. Louis were "messed up." She adds how she feels as a black woman in "a world dominated by non-black women":

I love my country, but I'm not in love with all of it. I hate that I'm scared to death one of my


Business Directories

Bahrain mulls 50-storey skyscrapers on coast

Manama, September 1, 2012

Skyscrapers up to 50 storeys tall could be lining the shores of the Seef area in Bahrain if a new zoning plan gets the green light, said a top official.

The Manama Municipal Council wants to reserve coastal land in the area for towering commercial and residential developments.

It wants to reduce the impact of such developments on residential neighbourhoods further inland.

Councillors fear that growing urbanisation could cause traffic congestion and spark complaints from people already living there about their privacy being invaded.

They want to impose new limits on the height of buildings, which will gradually rise in height the closer they are to the shore.

The council will now work with the Municipalities and Urban Planning Affairs Ministry to come upThe Last Book in the Universe

4.11 - 1251 ratings - Source

After an earthquake has destroyed much of the planet, an epileptic teenager nicknamed Spaz begins the heroic fight to bring human intelligence back to the Earth of a distant future.After an earthquake has destroyed much of the planet, an epileptic teenager nicknamed Spaz begins the heroic fight to bring human intelligence back to the Earth of a distant future.

Title

:

The Last Book in the Universe

Author

:

W. Rodman Philbrick

Publisher

:

Scholastic Inc. - 2002-03-01

ISBN-13

:

You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.

Once you have finished the sign-up process, you will be redirected to your download Book page.


                  field.widget.attrs['class'] += ' my-class'
                else:
                    field.widget.attrs.update({'class':'my-class'})
    class Meta:
        model = MyModel

can you override init with a decorator? also, there should be an if statement before the attrs.update() becuase I want to set a default rather than override what may already be there. – Kevin

Untested, but I guess you can just inherit from MyForm if you use this a lot.

A:

Create a new widget with your CSS class:
class

A:

Use the next code:-
select * from ordertable o
where ((o.orderdate > DATEADD(day, DATEDIFF(day, 2, GETDATE()), 0) )
and (o.orderdate < DATEADD(day, DATEDIFF(day, 1, GETDATE()), 0) ))

The approach is depends on getting the date only without time.
so if the today is 24th, the where criteria will be within
2017-05-22 00:00:00.000

&
2017-05-23 00:00:00.000


build on Bootstrap 3, 1170px Grid. This Bootstrap 3 Template has development is much easier than you think.

If you are looking for modern event, conference and meetup website, then EVENT will be the best choice for you.

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Don’t want to loose leads and customers ever again? We created these Responsive Landing Page Templates to help you with that goal. Our team researched all the best converting practices and implemented them in these landing page templates, you can be sure your business will flourish!for ‘Mourinho-ball’ tactics. His sides have always been structured, organised and difficult to beat, if at times uninspired. That made this defeat even more concerning. Any team can lose a game through ill-fortune or rash mistakes. In this case they were beaten by a better side, who weren’t required to do anything particularly special. The central defensive duo of Bailly and Lindelöf was, at best, shambolic.

For the last two seasons, Mourinho has made this team defensively sound. They boasted the second-best defensive record in the division last year, and any defeats were generally low-scoring affairs. Brighton, particularly in the first half, scored three goals and in truth could have scored more. Coupled with the lack of desire, there was no cohesion in the defensive unit. Bailly was frequently


the unity required to offer a stable platform. Every time Brighton came forward they looked vulnerable, and in possession they were caught time and again. It was a poor day at the office which cannot be repeated.

3. There is no defined style

It has been discussed at length in the media and with good reason – Manchester United have no defined style of play. Mourinho also does not know his best team, and this game only further exacerbated that problem. United are a reactive side. They do not impose themselves on the opposition, and they no longer inspire fear in their opponents. They sat back waiting to see how Brighton were going to shape up, and were soon shocked by the aggressive pressing of their supposedly inferior opponents.

Build up    09-1320-cv
    Young v . Benjamin Dev. I n c .

                      UNITED STATES COURT OF APPEALS
                          FOR THE SECOND CIRCUIT

                                  SUMMARY ORDER
RULINGS BY SUMMARY ORDER DO NOT HAVE PRECEDENTIAL EFFECT. CITATION TO A SUMMARY ORDER
FILED ON OR AFTER JANUARY 1, 2007, IS PERMITTED


U.S. D e ~ ' t of Veterans Affairs, 201 F.3d 94, 97
(2d Cir. 2000). Nonetheless, we conclude that the district
court committed no error in this case because Young failed
to file an affidavit setting forth the essential facts he
sought to discover. Fed. R. Civ. P. 56(f). " [Tlhe failure
to file an affidavit under Rule 56(f) is itself grounds to
reject a claim that the opportunity for discovery was
inadequate." Paddinaton Partners v. Bouchard, 34 F.3d 1132,
1137 (2d Cir. 1994).

     Even if Young had been granted the discovery he sought,
it would not have changed the outcome of this matter. When
the district court asked what evidence Young hoped to
present if discovery were permitted, Young indicated that he
would submit evidence regarding the deterioration in his
health subsequent to his termination.{#fsn3886-sec-0011}
----------------------------

The red sorghum extract was analyzed for total phenolic contents (TPC) following a laboratory protocol (Moore, Liu, Zhou, & Yu, [2006](#fsn3886-bib-0020){ref-type="ref"}). Briefly, 100 μl of sample was mixed with 500 μl of the Folin‐Ciocalteu reagent, 1.5 ml of 20 wt% sodium carbonate, and 6 ml of ultrapure water. After 2 hr of reaction, the absorbance at 765 nm was measured to calculate the TPC in samples using gallic acid as a standard. Results are expressed as milligrams of gallic acid equivalents per gram of dried red sorghum (mg GAE/g).

2.7. Total flavonoid contents {#fsn3886-sec-0012}
-----------------------------

The red sorghum extract was analyzed for total flavonoid contents (TFC) following a previous procedure with some modifications (Frassinetti et al., [2018](#fsn3886-bib-0011){ref-type="ref"}). Briefly, 250 μl of sample was mixed with 75 μl of 5 wt% sodium nitrite solution, 1 ml of ultrapure water and incubated at


The combined effect of hypertension and smoking on arterial stiffness.
Arterial stiffness plays a critical role in the function of the cardiovascular system as it represents the coupling of the left ventricle and arterial tree. Increased arterial stiffness is associated with a number of cardiovascular complications. Increased stiffness occurs with age and with the development of chronic conditions (e.g., hypertension) and the presence of vascular risk factors (e.g., smoking). Measuring arterial stiffness is increasingly gaining popularity as a method of assessing cardiovascular health and treatment efficacy. The purpose of this review was to assess the combined effect of hypertension and smoking on arterial stiffness. A systematic review of the literature revealed four relevant studies; hypertension and smoking were found to be independent detrimental factors for raising arterial stiffness, andcombined they raise arterial stiffness more than either solitary factor. However, a need was identified for future studies to determine the extent to which smoking cessation therapy combined with the appropriate anti-hypertensive medication can lead to stabilization or even reversal of arterial stiffness.


Diffuse emission and control of copper in urban surface runoff.
Copper washed off from roofs and roads is considered to be a major contribution to diffuse copper pollution of urban environments. In order to guarantee sustainable protection of soils and water, the long-term strategy is to avoid or replace copper containing materials on roofs and fagades. Until achievement of this goal, a special adsorber system is suggested to control the diffuse copper fluxes by retention of copper by a mixture of granulated iron-hydroxide (GEH) and calcium carbonate. Since future stormwater runoff concepts are based on decentralised runoff infiltration into the underground, solutions are proposed which provide for copper retention in infiltration sites using GEH adsorption layers. The example of a large copper façade of which the runoff is treatedthird derivative of 3*w**2 + 8*w**2 + c*w**4 + 6*w**4 wrt w?
432*w
Let h(l) = 4*l**2 - 43*l - 399. Let m(z) = -2*z**2 + 21*z + 194. Let r(b) = 3*h(b) + 5*m(b). What is the derivative of r(a) wrt a?
4*a - 24
Let h = 19 + -37/2. Let o(t) be the first derivative of -h*t**2 + 0*t**3 + 0*t + 3/4*t**4 + 2. Find the second derivative of o(g) wrt g.
18*g
Let o(y) be the first derivative of -3*y**5/5 - y**3/3 - 225*y + 209. Differentiate o(j) with respect to j.
-12*j**3 - 2*j
Let d(j) = 795*j**2 - 4*j + 642. Let q(t) = -3178*t**2 + 18*t - 2564. Let m(x) = -9*d(x) - 2*q(x). What is the derivative of m(z) wrt z?
-1598*z
Let r(l) be the second derivative of


$(x-r)$ and are left with $g(x)$ which is a polynomial of lower degree (then continue using induction).
If $R$ is not an integral domain, then cancellation laws do not hold and so you can have more than $n$ roots for a polynomial of degree $n$.
Now if $R$ isn't even commutative (even if $R$ has no zero divisors) it gets worse. Polynomials over the quaternions (a "non-commutative" field -- i.e. a skew field or division ring) can have more roots than their degrees.
So in general, if $R$ is non-commutative or if $R$ is commutative but with zero divisors, then polynomials with coefficients in $R$ do not necessarily have unique factorizations and so polynomials of degree $n$ can have more than $n$ roots.
Edit Quaternion example: Let $\mathbb{H} = \{that the "result was an extraordinary damages award against a parent holding company for conduct of persons who were . . . employees of an independent, lawfully formed corporate subsidiary." In response, Plaintiff asserts only that Defendant's "contentions of prejudice" are "red herrings" and that the case was not "simply one of nursing negligence but, rather, of direct corporate negligence in putting profits first and people last, which led to the conduct causing [Ms. Barber's] death." While Plaintiff does not expand on this assertion, we interpret Plaintiff's argument to be that if the district court erred by finding that Defendant was the employer of the Camino Vista staff, that error is harmless because Plaintiff also asserted a cause of action against Defendant for its own negligence.
{31} It is


based its verdict on erroneous contract instructions or on some other theory of damages).

Judicial Estoppel
{35} As noted above, the only argument Plaintiff makes in support of the court's ruling on the employment issue is that the court properly relied on judicial estoppel. We briefly address this argument because, under our "right-for-any-reason" doctrine, we could affirm the district court on the basis of judicial estoppel, assuming the doctrine were applicable, as long as "reliance on the new ground would [not] be unfair to appellant." Meiboom v. Watson, 2000-NMSC-004, ¶ 20, 128 N.M. 536, 994 P.2d 1154 (internal quotation marks and citation omitted).
{36} "Judicial estoppel is a doctrine that prevents a party who has successfully assumed a certain position in judicial proceedings from then assuming an inconsistent position, especially ifsection off the different components of who we are, and faith is often a big part of who a person is and what makes them tick. Stacey Lee’s novel Under A Painted Sky does an excellent job of weaving in faith alongside a compelling story. This should be explored not in special books focused on just the topic of faith but in any book in which faith plays a role in how a person operates.

Anthony Breznican: I think it’s interesting to see more YA with people who have faith in the ideas that a religion puts forth, even if they don’t have faith in the religion or the people who oversee it. I think we need to separate the idea of “right from wrong” from particular clubs. No


Carolina Oliveira

Carolina Machado de Oliveira (born November 29, 1994, in São José dos Campos, Brazil) is a Brazilian actress. In 2005, she was nominated for an International Emmy Awards for her role in the show Hoje É Dia de Maria.

Biography
Her first television appearance was in the Rede Globo miniseries Hoje É Dia de Maria, directed by Luiz Fernando Carvalho, having a continuing series called Hoje É Dia de Maria 2.

In 2009, she was in India – A Love Story, where she played Chanti Ananda, an Indian teenager who goes against traditions and wants to study abroad and not marry.

In 2010, she starred in the movie Amazônia Caruana, directed by Tizuka Yamasaki. In Ti Ti Ti, she played the role of Gabi, who becomes involved with the son- Var_X '+Var_X+' Var_Y '+Var_Y);
      end;
      CloseFile(arquivo);
    end;

end;

Coloquei os valores na linha abaixo para serem visto por voce..
RichEdit1.Lines.Add(linhasarq+ ' - Var_X '+Var_X+' Var_Y '+Var_Y);
Espero ter entendio seu problema e ter respondido claramente..
Qualquer coisa é só falar.. Abraços :)
paravra:= 'PU-3651 -2229;';
Uso do Pos(Substring,palavra) : Integer;
Var_T:= Pos('U',palavra); // = 3
Uso do COPY(palavra, de , ate).
Var_X:= Copy(palavra,4,Pos(' ',palavra)-1);
Ele ira Retorna 3651 pois estamos pedindo o Quarto caracter ate o primeiro espaço menos um ( -1)


Effects of the crossed acoustic reflex on distortion-product otoacoustic emissions in awake rabbits.
Recent studies in anesthetized cats suggest that contralateral-sound stimulation acts to suppress ipsilateral neural responses via the medial olivocochlear-efferent system. Activation of this descending efferent pathway presumably influences ipsilateral outer hair cell motility and, thus, cochlear micromechanics, resulting in reduced input to auditory-nerve fibers. The principal aim of the present study was to determine if contralateral-sound stimuli influence the generation of ipsilateral distortion-product otoacoustic emissions, in the ears of awake rabbits. The results showed no effects of contralateral stimuli on these emissions that could not be attributed to the crossed acoustic middle-ear reflex. The findings further indicate that distortion-product otoacoustic emission amplitudes over a wide range of frequencies can be dramatically reduced when the middle-ear reflex                No association vitamin D (plasma)[@R93] (intake)[@R96], dietary antioxidants[@R99] or folate[@R100] or vitamin A[@R101] supplements

   Breast feeding                                                        OR 0.92 (0.86 to 0.98)\*‡[@R102]\


allergen exposure and wheeze at 4 years,[@R53] and (3) HDM and cat exposure and asthma at 7 years.[@R54] One study reported increasing cockroach allergen exposure in infancy was positively associated with wheeze by age 5 years (OR 1.8) and, independently, the presence of a dog and higher concentrations of cat allergen exposure were associated with reduced wheeze risk (OR 0.3 and 0.6).[@R55] Dog allergen exposure in infancy was not associated with asthma at 7 years per se but was associated with asthma in combination with exposure to SHS (OR 2.7) or elevated NO~2~ (OR 4.8).[@R56] A final study observed interactions between exposures to SHS, breast feeding and recurrent respiratory infections and asthma.[@R57]

Pet exposure: There were two systematic reviews, one meta-analysis and six cohort studies identified and the results were highly inconsistent. OneValidation of quantitative analysis of multiparametric prostate MR images for prostate cancer detection and aggressiveness assessment: a cross-imager study.
To validate three previously identified quantitative image features across multiparametric magnetic resonance (MR) images acquired with imagers made by two different manufacturers to differentiate prostate cancer (PC) from normal prostatic tissue and to assess cancer aggressiveness. This study was HIPAA-compliant and approved by the institutional review board. Preoperative 1.5-T multiparametric endorectal MR images of 119 PC patients (dataset A, 71 patients; dataset B, 48 patients) were analyzed, and 265 PC and normal peripheral zone regions of interests (ROIs) were identified through histologic and MR consensus review. The 10th percentile average apparent diffusion coefficient (ADC) value, average ADC value, and skewness of T2-weighted signal-intensity histogram were evaluated with area under the


slow macro play, just as they had been at Worlds 2017, but adjusted accordingly with a greater focus on objectives, primarily Baron.

That increased competition in the LMS also meant that Flash Wolves’ native talent had to step up, namely their mid laner, Maple. This split, Maple reminded everyone why he was the first mid lane prodigy in the region. His spunky, aggressive play set a tone for Flash Wolves this split and the mechanics returned to back it up. Maple isn’t the star of this team anymore, but there’s no “Flash” in Flash Wolves without his individual playmaking in teamfights.

Betty and SwordArt further solidified themselves as the best bot lane in the LMS last year and although G-Rex’s Koala was voted as the All-Pro Team Support, SwordArt isTaiwan and a corresponding placard that clarified the institution's position regarding the controversy.

In October 2019, Wallinger featured in a group show at Tension Fine Art alongside artists Julian Lowe and Stuart Elliot. The show "You Can't Tell By Looking" was curated by Kate Love.

Recognition
In 2007, Wallinger won the Turner Prize for his work, State Britain — this was his second Turner Prize nomination.

As part of the Transported by Design programme of activities, in 15 October 2015, after two months of public voting, Mark Wallinger's Labyrinth work was elected by Londoners as one of the 10 favourite transport design icons.

Art market
Wallinger is represented by carlier | gebauer in Germany, Galerie Krinzinger in Austria, and Hauser & Wirth elsewhere.

Personal life
Wallinger is a supporter of the Labour Party. In


  response.end();
        });
};

I want to test that all the components work together but with a fake HTTP response, so I am creating a stub for the request/http interactions.
I am using Chai, Sinon and Sinon-Chai and Mocha as the test runner.
Here's the test code:
var chai = require("chai"),
    should = chai.should(),
    sinon = require("sinon"),
    sinonChai = require("sinon-chai"),
    route = require("../routes"),
    request = require("request");

chai.use(sinonChai);

describe("product service", function () {
    before(function(done){
        sinon
        .stub(request, "get")
        // change the text of product name to cause test failure.
     4

needed] to compare to the pump requirements” and “taken together, are

necessary for Z&F to make the proper selection of a motor in its quotation.”

Larson understood the plans and specifications’ intent was for Z&F’s motors to

be compatible with the pumps.

       Z&F did not have amperage requirements for its motors when providing its

quotation, even though HDR had specified amperage for other equipment.3

Neither did the bid documents tell Z&F to “replace in kind” or to “replace with

compatible motor,” which, similarly, HDR specified for other equipment. Larson

understood the plans and specifications for the new motors “weren’t asking us to

duplicate” the existing motors, and he created Z&F’s quotation based on HDR’s

plans and specifications.

       On May 30, 2012,


can be reasonably inferred from what is stated”;

(2) if HDR’s plans and specifications, although imperfect, would lead a

reasonable person to conclude that what needs to be supplied is a “plug and

play” motor, then that is what has to be provided to the city; and (3) the city had

the contractual right to insist Rice Lake replace Z&F’s motors, which would need

modifications and did not “meet the design intent,” with “plug and play” motors

that “would meet the intent of the design.”9

9
    The prime contract between Rice Lake and the city states:
         It is the intent of the Contract Documents to describe a functionally
         complete Project (or part thereof) to be constructedOwner and

Engineer for all acts and omissions of the [Suppliers furnishing] any of the Work

just as Contractor is responsible for Contractor's own acts and omissions.” Rice

Lake cites no similar contract provision, in either the prime contract or the supply

contract, stating Z&F “shall be fully responsible” to Rice Lake by undertaking

Rice Lake’s obligations to coordinate work as the project’s general contractor.10

10
  In support of its position Z&F is responsible for Rice Lake’s obligations, Rice Lake
quotes Central Iowa Grading, Inc. v. UDE Corp., 392 N.W.2d 857, 860 (Iowa 1986), a
case in equity involving statutory mechanic’s liens, which broadly states: “The principal
contractor is, of course, bound by the terms of his contract with the owner. In the


foreclose mechanic’s lien and recognizing “mechanic's lien is purely
statutory in nature”); Eherenman v. Warren, No. 13-1764, 2014 WL 7343386, at *2 (Iowa
Ct. App. Dec. 24. 2014) (discussing change orders in the context of mechanic’s liens);
Palmer v. Glasbrenner, No. 03-0492, 2004 WL 1159736, at *3 (Iowa Ct. App. May 26,
2004) (discussing change orders and subcontractor’s extra work in context of
mechanic’s lien); Booth v. Pilot Corp., No. 99-0925, 2001 WL 726364, at *6 (Iowa Ct.
App. June 29, 2001) (resolving mechanic’s lien dispute as to change orders and extra
work). These cases show Central Iowa Grading is distinguishable. No Iowa court has
applied the broad proposition Rice Lake cites in a similar contract analysis.
                   Hemodynamic responses of thiopental and propofol in different-aged patients during endotracheal intubation.
Thiopental and propofol are 2 popularly used anesthetic induction agents that have different pharmacological and pharmacokinetic actions. It is not clear how the hemodynamic responses differ in different-aged patients using these 2 drugs for anesthetic induction. The aim of this study was to investigate the hemodynamic responses to propofol and thiopental of different-aged patients during endotracheal intubation. Sixty patients, 20 to 83 years old, were included in this study. Patients were randomly divided into 6 groups according to age and different inductive anesthetics. Non-invasive blood pressure (NIBP) monitoring was performed every minute before anesthesia, during anesthetic induction with 5 mg.kg-1 thiopental or 2 mg.kg-1 propofol intravenously, and after intubation. Propofol induction produced a smaller mean arterial pressure


targeting these interactions, in addition to the cancer cells themselves, can produce synergistic therapeutic effects against existing metastases. However, Pienta et al.[84](#med21423-bib-0084){ref-type="ref"} state that describing metastasis in terms of a simple one‐way migration of cells from primary to target organs is insufficient to cover the nuances of cancer spread. Pienta et al.[84](#med21423-bib-0084){ref-type="ref"} thus raise the question of whether cancer cells escape the confinement of their original habitat in the primary tumor or are they forced out by ecological changes in their home niche? These authors consequently propose an innovative concept of "diaspora," which is a term used by social scientists to describe the scattering of people away from an established homeland.[84](#med21423-bib-0084){ref-type="ref"} They argue that invoking the ecological and population science concepts can help understand the biology of tumorigenesis and metastasis,cells via the secretion of cytokines, growth factors, and proteases that remodel the tumor microenvironment.

### 7.. Tumor Microenvironment {#med21423-sec-0110}

Berns and Pandolfi[88](#med21423-bib-0088){ref-type="ref"} emphasize the major role played by stromal cells in the development of a cancer, citing the example of pancreatic cancer in which stromal cells and their deposited matrices can make up to 90% of the tumor mass. Cancer‐associated fibroblasts actively interact with cancer cells and form a myofibroblastic microenvironment that promotes cancer growth and survival and supports malignancy.[89](#med21423-bib-0089){ref-type="ref"} It appears that specific oncogenes induce cancer‐associated fibroblast phenotype.[45](#med21423-bib-0045){ref-type="ref"} Berns and Pandolfi[88](#med21423-bib-0088){ref-type="ref"} report that stromal components might contribute to drug resistance by creating a physical barrier limiting drug access, secreting growth‐promoting or antiapoptotic factors, providing niches for CSCs, or by mediating immunosuppression. These authors accordingly argue that combining treatments


that degrade the tumor stroma with immunomodulation could be effective given the remarkable success of immunomodulation in a number of tumors and the notion that the tumor microenvironment plays an important role in immune suppression.[88](#med21423-bib-0088){ref-type="ref"}

Another crucial point in cancer biology is the notion of cancer cell fueling by noncancer cells. For example, autophagic senescent fibroblasts metabolically promote tumor growth and metastasis by paracrine production of high‐energy mitochondrial fuels.[90](#med21423-bib-0090){ref-type="ref"} Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.[91](#med21423-bib-0091){ref-type="ref"} Sotgia et al.[92](#med21423-bib-0092){ref-type="ref"} thus state that as metabolic symbiosis promotes drug resistance and may represent an escape mechanism during antiangiogenic therapy, new drugs targeting metabolic symbiosis may also be effective in cancer patients with recurrent and advanced metastatic diseases.

Tabassum and Polyak[93](#med21423-bib-0093){ref-type="ref"} compare tumorigenesis to a village. These authorsgenerated by a colorimetric assay, not only in cancer, but also in normal cells.

The GI~50~ indexes that precisely define the ranges "weakly active," "active," and "highly active" are not unanimously agreed upon in the literature. The instructions for authors of the *Journal of Natural Products* define a compound to be inactive if its GI~50~ value is higher than 10 μM. The NCI also uses 10 μM as the highest dose for compounds tested in the 60 cell line panel. However, some compounds that work through nonapoptotic mechanisms (e.g., inducers of senescence or autophagy) can display GI~50~ values higher than 10 μM. Thus, we took these issues into account in comments about the "promise" associated with a given anticancer compound.

### 2.. Selectivity {#med21423-sec-0150}

The term "selective" is not a synonym


                             *Halichondria* (sponges)

John Wiley & Sons, Ltd.

B.. Dolastatins {#med21423-sec-0220}
---------------

We describe below the cyanobacterial metabolites of the dolastatin type. However, it must be recalled that these types of compounds did not successfully complete clinical trials, usually exiting trials at or before the Phase II level. Thus, though we detail below the use of agents derived from dolastatins as potential anticancer agents, it should be noted that most of the Phase I trials did not proceed any further. Therefore, dolastatins can no longer be labeled as "promising anticancer drugs."

Dolastatins (**1a‐14b**; Figs. [2](#med21423-fig-0002){ref-type="fig"}, [3](#med21423-fig-0003){ref-type="fig"}, [4](#med21423-fig-0004){ref-type="fig"}, [5](#med21423-fig-0005){ref-type="fig"}, [6](#med21423-fig-0006){ref-type="fig"}) embody a large family of activeto know how efficient elatol is against B16F10 melanoma cells that are intravenously transplanted in syngeneic mice and lead to aggressive lung pseudometastases.[311](#med21423-bib-0339){ref-type="ref"} Indeed, the murine B16F10 melanoma model is not at all representative of the great majority of human melanomas associated with dismal prognoses that display marked resistance to proapoptotic stimuli.[67](#med21423-bib-0067){ref-type="ref"} Obtusol and isoobtusol display weaker *in vitro* growth inhibitory activity than elatol.[293](#med21423-bib-0321){ref-type="ref"}, [307](#med21423-bib-0335){ref-type="ref"}, [309](#med21423-bib-0337){ref-type="ref"}

Two sesquiterpenes named 1‐formamido‐10(1→2)‐abeopupukeanane (**25a**; Fig. [7](#med21423-fig-0007){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"} under pupukeanane derivatives) and 2‐formamidopupukeanane (**25b**; Fig. [7](#med21423-fig-0007){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"}) were recently isolated and chemically characterized from the nudibranch *Phyllidia coelestis* (Fig. [1](#med21423-fig-0001){ref-type="fig"}L; Table [I](#med21423-tbl-0001){ref-type="table-wrap"}).[312](#med21423-bib-0340){ref-type="ref"} As emphasized by Jaisamut and colleagues,[312](#med21423-bib-0340){ref-type="ref"} tubercle nudibranchs of the genus *Phyllidia* graze on sponges and can sequester specific sponge metabolites. For example, *P. varicosa* secretes in its mucus


respectively.[313](#med21423-bib-0341){ref-type="ref"} As mentioned above, tubercle nudibranchs of the genus *Phyllidia* feed on their sponge prey from the *Ciocalypta* genus,[312](#med21423-bib-0340){ref-type="ref"} and thus, the possibility remains that the nudibranch *R. fungia* also feeds on sponges, which could belong to *Pseudoaxinyssa pitys*, *Stylotella aurantium*, and *Axinyssa sp*. genera.[313](#med21423-bib-0341){ref-type="ref"}

![Chemical structures of reticulidins A (**26a**) and B (**26b**), oculiferane (**27**), *epi*‐obtusane (**28**), parguerol (**29a**), parguerol‐16‐acetate (**29b**), isoparguerol (**29c**), isoparguerol‐16‐acetate (**29d**), deoxyparguerol (**29e**), and dorisenone A (**30a**), B (**30b**), C (**30c**), and D (**30d**).](MED-37-702-g008){#med21423-fig-0008}

Two novel halogenated sesquiterpenes were isolated from the digestive glands of the Egyptian sea hare *Aplysia oculifera* (Table [I](#med21423-tbl-0001){ref-type="table-wrap"}).[314](#med21423-bib-0342){ref-type="ref"} These two compounds, oculiferane (**27**; Fig. [8](#med21423-fig-0008){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"}) and *epi*‐obtusane (**28**; Fig. [8](#med21423-fig-0008){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"}), displayed GI~50~ values ranging between ∼2 and ∼8 μM in a minipanel of five human cancercyclin B1, cyclin A, CDC2, and CDC25C.[419](#med21423-bib-0447){ref-type="ref"} The growth inhibitory effects induced by halichondramide in A549 NSCLC cancer cells were also associated with the suppression of mTOR and its downstream effector 4EBP1 and p70S6K; this process occurs by its effects on the regulation of mTOR upstream proteins, such as downregulation of Akt and p38 MAPK, and also upregulation of AMPK.[419](#med21423-bib-0447){ref-type="ref"} As already mentioned previously, the A549 NSCLC cell line displays various levels of resistance to proapoptotic stimuli.[351](#med21423-bib-0379){ref-type="ref"} In terms of antimigratory effects observed *in vitro*, halichondramide suppresses the expression of a potential metastatic biomarker, phosphatase of regenerating liver‐3 (PRL‐3), in human PC‐3 prostate cancer cells.[418](#med21423-bib-0446){ref-type="ref"} The suppression of PRL‐3 sequentially downregulates the expression of phosphoinositide 3‐kinase (PI3K) subunits p85 and p110.[418](#med21423-bib-0446){ref-type="ref"} The antimigratory (antimetastatic) effects induced by this


3‐acetyl‐11‐(3‐methylbutanoyl)‐13‐propanoylilikonapyrone (**65**; Fig. [18](#med21423-fig-0018){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"}) in a minipanel of six human cancer cell lines: A549 NSCLC, MCF‐7 breast cancer, PC‐3 prostate cancer, Hs683 oligodendroglioma, U373 glioblastoma, and SKMEL‐28 melanoma.[449](#med21423-bib-0477){ref-type="ref"} The GI~50~ values were very similar and ranged from 3 to 9 μM, without any correlation with the level of sensitivity of these cancer cell lines to proapoptotic stimuli, indicating therefore that this metabolite is active against cancer cells displaying resistance to proapoptotic stimuli.[449](#med21423-bib-0477){ref-type="ref"}

Sphinxolides bear structural resemblance to scytophycins, which are found in cyanobacteria, such as *Scytonema pseudohofmanni*.[447](#med21423-bib-0475){ref-type="ref"}, [450](#med21423-bib-0478){ref-type="ref"} Sphinxolide (**66**; Fig. [19](#med21423-fig-0019){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"}) is a 26‐membered macrolide that was first isolated from an unidentified Pacific nudibranch[451](#med21423-bib-0479){ref-type="ref"} and later reisolated from the New Caledonian marine sponges *Neosiphonia superstes* and *Reidispongia coreula*, along with the congeneric reidispongiolides.[452](#med21423-bib-0480){ref-type="ref"}, [453](#med21423-bib-0481){ref-type="ref"}

Likedespite this research activity, no *in vivo* efficacy has been demonstrated yet for lamellarins in general and for lamellarin D in particular, at least to the best of our knowledge. A bioguided fractionation of various extracts of the prosobranch mollusk *Coriocella nigra* resulted in the isolation of two members of the staurosporine[488](#med21423-bib-0516){ref-type="ref"} (selective kinase inhibitor) family: compounds **77a** (4'‐*N*‐demethyl‐11‐hydroxystaurosporine; Fig. [22](#med21423-fig-0022){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"} under staurosporine analogues) and **77b** (3,11‐dihydroxystaurosporine; Fig. [22](#med21423-fig-0022){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"}).[489](#med21423-bib-0517){ref-type="ref"} Their GI~50~ values in a minipanel of cancer cell lines ranged between 4 and 130 nM.[489](#med21423-bib-0517){ref-type="ref"}

Tambjamines are methoxypyrrolic alkaloids whose chemical features resemble the bacterial prodigiosins.[490](#med21423-bib-0518){ref-type="ref"}, [491](#med21423-bib-0519){ref-type="ref"}, [492](#med21423-bib-0520){ref-type="ref"} All these compounds contain a common 4‐methoxy‐2,2'‐bipyrrole chromophore.[491](#med21423-bib-0519){ref-type="ref"}, [492](#med21423-bib-0520){ref-type="ref"} Tambjamines A--D (tambjamine D; **78a**; Fig. [22](#med21423-fig-0022){ref-type="fig"}; Table [II](#med21423-tbl-0002){ref-type="table-wrap"}) were isolated from the nembrothid nudibranchs *Roboastra tigris, Tambja


the N109C‐vcMMAE conjugate to target the tumors, potentially by taking advantage of the EPR effect.[545](#med21423-bib-0573){ref-type="ref"} The antitumor efficacy of the conjugate was not evaluated in this animal model.

Temming et al.[546](#med21423-bib-0574){ref-type="ref"} developed arginine‐glycine‐aspartic acid (RGD)‐targeted albumin carriers for MMAE. Specifically, MMAE‐human albumin conjugates **99a** and **100a** (Fig. [28](#med21423-fig-0028){ref-type="fig"}) decorated with cyclic c(RGDfK) peptides were used to target and cause apoptosis of α~ν~β~3~‐integrin‐expressing angiogenic endothelial cells, thereby destroying the tumor\'s blood supply.[546](#med21423-bib-0574){ref-type="ref"} These conjugates also utilized a valine‐citrulline linker to enable intracellular release of MMAE from the albumin carrier upon activation by lysosomal cathepsin.[546](#med21423-bib-0574){ref-type="ref"} The two carriers differed in the use of either a short alkyl chain (**99a**) or a poly(ethylene glycol) (PEG) spacer (**100a**) for attachment of the targeting RGD peptide. Both carriers showed high specificity toward, internalization into, andOnly a greater Pharma‐Academia collaboration could overcome the barrier of the valley of death in the development of new effective anticancer therapies.[570](#med21423-bib-0606){ref-type="ref"}

7.. CONCLUSIONS: WHAT ARE THE MOST PROMISING MOLLUSK‐DERIVED ANTICANCER COMPOUNDS? {#med21423-sec-0340}
==================================================================================

Of note, no "recent" mollusk‐derived compounds have attained late Phase II or Phase III clinical trials in oncology. However, we think that several "mollusk‐derived" compounds merit further consideration.

In terms of *in vivo* activity, we think that a compound for which clear evidence of activity has been demonstrated in various models (including aggressive metastatic) has a greater probability to move toward clinical trials than a compound that has not been assayed *in vivo*, displays no activity *in vivo*, or whose *in vivo* activity has been demonstrated, for example, in ascitic models of mouse leukemia, which are by far


primary focus of his work is on the study of the ecological roles of natural products from marine organisms and their phyletic and geographic distribution in nature. His research campaigns for the exploration of the molluscan biological and chemical diversity have been carried out on a global scale and led to the discovery of many novel bioactive metabolites.

**Margherita Gavagnin** received her doctoral degree in Organic Chemistry in 1983 from University of Naples. In 1985 she moved to the Institute of Biomolecular Chemistry (ICB), Italian National Council of Research (CNR) where she joined the group of Prof. G. Cimino and started working on the chemical ecology of marine opisthobranch molluscs. Currently, she is Research Director at ICB. Her researches are mainly focused to the definition of the structure ofEighth Amendment’s ban on cruel and unusual punishment. The Court said that an IQ of under “approximately 70” demonstrates disability. However, the Atkins decision left states to define what it refered to as “mental retardation.” (Though clinicians now use the term “intellectually disabled,” the courts still use this older term.)

Most states have opted to use the clinical definition of intellectual disability, which is based on three factors: limitations in intellectual functioning; limitations in adaptive behavior; and the onset of these limitations before age 18 (after age 18, it is considered dementia). Like the Supreme Court, the American Association of Intellectual and Developmental Disabilities uses IQ to measure intellectual ability, with a score of around 70 and “as high as 75” qualifying as limited. The adaptive behavior standard is


chmod +x test-stack@python.sh \
  && bash test-stack@python.sh \
  && rm -rf test-stack@python.sh

RUN [ ! -d /.balena/messages ] && mkdir -p /.balena/messages; echo 'Here are a few details about this Docker image (For more information please visit https://www.balena.io/docs/reference/base-images/base-images/): \nArchitecture: ARM v7 \nOS: Debian Sid \nVariant: build variant \nDefault variable(s): UDEV=off \nThe following software stack is preinstalled: \nPython v3.6.11, Pip v20.1.1, Setuptools v49.1.0 \nExtra features: \n- Easy way to install packages with `install_packages <package-name>` command \n- Run anywhere with cross-build feature  (for ARM only) \n- Keep the container idling with `balena-idle` command \n- Show base image details with `balena-info` command' > /.balena/messages/image-info

RUN echo '#!/bin/sh.real\nbalena-info\nrm -f /bin/sh\ncp /bin/sh.real /bin/sh\n/bin/sh "$@"' > /bin/sh-shim \
	&& chmod +x /bin/sh-shim \
	&& cp /bin/sh /bin/sh.real \
	&& mv /bin/sh-shim /bin/shEntry of microbes into the host: using M cells to break the mucosal barrier.
Enteric microbial pathogens interact with the gut epithelium to establish infection. Recently, it has become clear that many microorganisms that colonize or traverse the intestinal mucosa do so via the specialized M cells. Recent work has shown that Shigella flexneri and Salmonella typhimurium specifically target M cells to initiate infection of the host.


Vern. You can then send the deeds to Nellie for her signature and she can return them to me.
"HARVEY: Say, do you have my address?
"THOMSON: No, I don't. I am glad vou reminded me of that.
"HARVEY: It is a long one  Lot 34 Canyon Acres Trailer Ranch, 8209 Black Canyon Highway, Phoenix 21, Arizona.
"THOMSON: Thanks.
"HARVEY: Okie-dokie, that is fine."
This is the contract entered into between the parties, and which is the subject of this litigation.
Plaintiff Harvey Reuter when he was a witness at the trial admitted in substance the correctness of the testimony of Mr. Thomson and Miss Weinkauf as to the conversations *820 of April 17, 1963. His testimony was as follows:
"Q. Now, I will ask you this, Mr. Reuter. Isn't this what Mr. Thomson told+ 4*n + 4. Let g be s(-1). Let b be (-174)/46 - (-9)/(4 - g). Which is smaller: 0 or b?
b
Suppose 0 = -10*l - 9*l + 76. Suppose 0 = -2*c + 5*d - 209, -2*c - 91 = l*d + 73. Which is smaller: c or -91?
c
Suppose 4*v + 25*g - 5245 = 30*g, 0 = 5*v + g - 6549. Is 1310 equal to v?
True
Let f = 225.6 - 0.6. Let o = -225.1 + f. Let a = 1807/10 - 180. Which is smaller: o or a?
o
Let r be (-104142)/565760 - (-28)/(-910). Which is bigger: r or 1?
1
Let w = -9 - -25. Let m = -522/13 - -3559/65. Which is bigger: m or w?
w
Let c = 5 + 0. Suppose 10*q -


z - -30. Does t = f?
False
Let d = -732 - -733. Which is greater: d or -581?
d
Let v(j) = j - 8. Suppose -4*g - 22 = 14. Let m be ((-3)/g)/((-2)/(-66)). Let n be v(m). Is -9 equal to n?
False
Let z(m) = -m**3 + 13*m**2 + 16*m - 18. Let c be z(14). Suppose 8*s - 2 = -c. Let l = -164.02 + 164. Which is bigger: s or l?
l
Let t(x) = -x**3 - 7*x**2 - 4*x + 6. Let j be t(-7). Let f = j + -32. Suppose 5*i + 2*c + 118 = 0, 2*i + i + f*c + 70 = 0. Do i and -25 have different values?
True
Let t = -25.9 + 26. Let a = -374.88 + 397. LetQ:

WPF ListView control

How to add hyperlink column in wpf listview at runtime ?

A:

Thanks a lot to all of you, But now I got a good solution which is...
GridView gridView = new GridView();

FrameworkElementFactory tbContent;
FrameworkElementFactory hl;
DataTemplate dTemp;
GridViewColumn gvc;
FrameworkElementFactory tb;

tbContent = new FrameworkElementFactory(typeof(TextBlock));
tbContent.SetBinding(TextBlock.TextProperty, new Binding(backCheckViewModel.responseDetails.Columns[index].ColumnName));
hl = new FrameworkElementFactory(typeof(Hyperlink));
hl.AddHandler(Hyperlink.ClickEvent, new RoutedEventHandler(hyperLinkClick));
hl.AppendChild(tbContent);
tb = new FrameworkElementFactory(typeof(TextBlock));
tb.AppendChild(hl);
dTemp = new DataTemplate();
dTemp.VisualTree = tb;
gvc = new GridViewColumn();
gvc.Header = backCheckViewModel.responseDetails.Columns[index].ColumnName;
gvc.CellTemplate = dTemp;
gridView.Columns.Add(gvc);

lstResponses.View = gridView;