for teacher and student creativity, less time for the arts and other non-tested subjects, and a laser-like focus on moving scores higher.

An irony in all this is that one of the favored words of the business-minded reformers who continue to push a results-driven, corporate model of school change is “innovation.” Of all the buzzwords that zip through current conversations about school improvement, it may be the most repeated. It peppers the language of Race to the Top, and charter school cheerleading, and teacher recruitment pitches. If you’re not talking about innovating, you’re probably not getting heard.

But the word, like so many others in education, has been hijacked. The “new reformers” have appropriated it as a descriptor for policy proposals and practices they advocate, and as an antonym for1. Field of the Invention
The present invention relates to image display devices for displaying, for example, images and icons concerning various settings, etc., and, in particular, to an image display device, an image pickup apparatus, an image display control method, and a program that prevent unintended setting and unintended operation with an operation input unit such as a touch panel.
2. Description of the Related Art
Image pickup apparatuses of the related art, such as digital still cameras and digital video cameras, have liquid crystal panels such as liquid crystal displays. The image pickup apparatuses can also display not only picked-up images but also predetermined icons concerning various settings. In addition, nowadays, there is an image pickup apparatus including an operation input unit such as a touch panel. By tapping


getting ever harder to control its members, having asked them for 'calm and serenity' today.” Union officials, El País added, “denied there was a strike and insisted that the protest was 'spontaneous.'”same time, $a$ and $b$ have the same performance on $g_{Fin}$ (5) as happens also for $c$ and $d$ (8). Consequently, if $\left\{g_{Eco},g_{Gov}\right\}$ would be preferentially independent of $g_{Fin}$, the preference of $a$ over $b$ should imply the preference of $c$ over $d$ even if, the provided assignments of $c$ and $d$ imply exactly the opposite preference. This is due to the fact that there is a certain degree of interaction between the criteria at hand.

The very didactic example shown above proves that eventual positive or negative interactions between criteria need to be properly taken into account in MCDA methods developed to deal with sorting problems.

Background {#prel}
==========

In this section, we shall briefly introduce the notation that will be used along the paper, together with the methods that constitute


criteria descending from $g_\mathbf{r}$, where $C_{p_{\mathbf{r}}}$ is the class of top performing alternatives and $C_1$ is the class of the worst alternatives. Of course, the number of class to which an alternative can be assigned can be dependent on the considered criterion and has not to be the same for all criteria.

According to [@CorrenteEtAl2017a], we consider a *threshold based* sorting procedure. This means that each class $C_h$ is defined by a lower threshold $b^{\mathbf{r}}_{h-1}$ and an upper threshold $b^{\mathbf{r}}_{h}$. To perform the assignment, we need, therefore, $p_{\mathbf{r}}+1$ thresholds $b_{0}^{\mathbf{r}},\ldots,b_{p_{\mathbf{r}}}^{\mathbf{r}}$ for each criterion $\mathbf{r}$, such that $0=b^{\mathbf{r}}_{0}<\ldots<b^{\mathbf{r}}_{p_{\mathbf{r}}}$ and $b^{\mathbf{r}}_{p_{\mathbf{r}}}$ is the highest possible evaluation of an alternative on $g_{\mathbf{r}}$. This means that $b_{p_{\mathbf{r}}}^{\mathbf{r}}=Ch_{\mathbf{r}}\left(opt_{\mathbf{t}_1},\ldots,opt_{\mathbf{t_r}}\right)$, where $\mathbf{t}_{1},\ldots,\mathbf{t}_{r}\in E\left(g_{\mathbf{r}}\right)$ are the indices of the elementary criteria descending from $g_{\mathbf{r}}$ and $opt_{\mathbf{t}}=\displaystyle\max_{a\in A}g_{\mathbf{t}}(a)$A \;\mbox{and}\; a\xrightarrow[\mbox{DM}]{}C_h\right\}$ that is, $b_{h-1}$ is equal to the minimum value of the Choquet integral of all alternatives assigned by the DM to the class $C_h$. The same thresholds are then used to assign all the other alternatives which are not provided as reference examples by the DM.

As mentioned above, our proposal is different from [@Roubens2001] for several reasons. First of all, in our approach the thresholds are considered as variables and are not defined ex-post from the assignments provided by the DM. Indeed, in [@Roubens2001], the assignment of non-reference alternatives is strictly dependent on which alternatives are provided as reference examples from the DM. Let us explain this point more in detail. Let us assume that the DM is dealing with a simple problem in which


than ${b}_{1}$. In such case, the hypothetical classification of the DM would not be restored. Instead, in our approach the thresholds are not fixed. We consider all the thresholds compatible with the preference information provided by the DM. The assignment of only ${a}_{1}$ to ${C}_{2}$ does not avoid that other alternatives could be assigned to ${C}_{2}$ as well.

The other differences are mainly due to the fact that we are taking into account a hierarchical structure of criteria permitting, therefore, to get alternatives’ assignments not only at comprehensive level but also considering a particular node of the hierarchy and, moreover, the fact that we are considering robustness concerns by using the NAROR and the SMAA methodologies. Indeed, while in [@Roubens2001] the proposed procedure gives a single capacity for whichthe Choquet integral is compatible with the preferences provided by the DM and the same capacity is therefore used to perform the assignment of the remaining alternatives, in our approach we are taking into account all the capacities compatible with the provided preferences giving, consequently, more stable results.\
Let us observe that other contributions developing the procedure introduced in [@Roubens2001] have been proposed in [@MarichalMeyerRoubens2005; @MarichalRoubens2001; @MeyerRoubens2005]. In particular, [@MeyerRoubens2005] introduced the TOMASO software implementing the procedure previously described, while [@MarichalMeyerRoubens2005] studied the potentialities of the same method by means of two examples.

Finally, another contribution dealing with the use of the Choquet integral preference model (not only the 2-additive one) for sorting problems, is due to [@BenabbouPernyViappiani2017]. Anyway, in that paper, the authors deal not only with sorting but


also with ranking and choice problems from an artificial intelligence point of view. They propose several procedures to reduce, iteration by iteration, the space of capacities compatible with the preferences provided by the DM[^9].

Case study {#CaseStudy}
==========

In this section, we shall apply the proposed methodology to sovereign ratings of the countries belonging to the European Union (EU)[^10]. The 28 Countries are evaluated with respect to three macro-criteria and 11 elementary criteria descending from them described in Table \[glossary\] and articulated as shown in Fig. \[Hierarchy\]:

-   Economic (Ec) $(g_{\mathbf{1}})$:

    -   GDP per capita (GDPc) $(g_{\mathbf{(1,1)}})$,

    -   Investment/GDP (I/GDP) $(g_{\mathbf{(1,2)}})$,

    -   Savings/GDP (S/GDP) $(g_{\mathbf{(1,3)}})$,

    -   Exports/GDP (Ep/GDP) $(g_{\mathbf{(1,4)}})$,

- for each of the two considered models compatible with the preferences provided by the DM ($WS$ and $CH$ or $CH$ and $MSCH$) we sample 10,000 compatible instances and we perform the assignment of all countries with respect to all sampled compatible models. Regarding $MSCH$, we sample 10,000 compatible models for each considered minimal set of pairs of interacting criteria. This means that if 3 minimal sets are able to restore the reference assignments, then we shall sample 30,000 compatible instances getting, therefore, 30,000 different countries’ assignments,

Step 4’

:   for each of the two considered models compatible with the assignments provided by the DM ($WS$ and $CH$ or $CH$ and $MSCH$) we compute the CAI of all countries at hand considering the assignments performed at the previous step,

Step


the reference assignments the percentage of correct assignments is almost always lower than the corresponding percentage for $CH$ and $MSCH$ being able to take into account the interaction between pairs of elementary criteria.\
Finally, comparing $CH$ and $MSCH$, it seems that the second presents better percentages of correct assignments in the case $p=50$, they are comparable for $p=75$ and $CH$ seems better than $MSCH$ for $p=100$.

Conclusions {#concl}
===========

Several methods have been proposed in Multiple Criteria Decision Aiding (MCDA) to deal with sorting problems in which alternatives need to be assigned to one among the considered classes ordered from the worst to the best with respect to the preferences provided by the Decision Maker (DM). Despite many real world sorting problems involve alternatives evaluated on interacting criteria, very few works havewent ahead. I had already been assured that this did not mean the end of the Norcross M55 link but wanted to make sure that plan was still on the table.

“While this investment will help relieve one part of this busy route, it is important the rest of the road is not forgotten when looking at future infrastructure projects.”


the lambent lighting schemes of Luchino Visconti's segment to the brash primary colors of Pier Paolo Pasolini's with equal aplomb. Civic Sense deploys a lot of hectic handheld camerawork, and The Sicilian Belle is dominated by solemn blacks and earthy browns. Vittorio De Sica's segment uses diffuse lighting and a slightly out-of-focus image to differentiate between Giovanna's imaginings and her humdrum reality. Arrow's 2K restoration of the film reveals more in the way of fine details, and boasts deeper blacks and a bolder color palette, compared to the earlier DVD from MGM. It's also free from practically all the blemishes that were displayed in that transfer, save for a stray hair or two caught in the gate.

Piero Piccioni scored four of the film's episodes, providing a jaunty, jazzyQ:

JSON.Stringfy method's replacer argument not working on nested object

I have an object, I want to send this object's simplified version to the server.
{
 "fullName": "Don Corleone",
 "actor": {
  "actorId": 2,
  "name": "Marlon",
  "surname": "Brando",
  "description": "Marlon Brando is widely considered the greatest movie actor of all time... ",
  "heroList": [],
  "photo": "C:\\projects\\files\\actor\\1532955376934.png"
 },
 "heroProfilePhoto": "data:image/png;base64,/9j/...
 "production": {
  "title": "The Godfather",
  "imdbRate": 9.2,
  "genre": "8",
  "releaseDate": "1972-03-23T21:00:00.000Z",
  "director": "Francis Ford Coppola",
  "writer": "Mari Puzo",
  "detail": "The aging patriarch of an organized crime dynasty transfers control of his clandestine empire to his reluctant son."
 }
}"

I have two question::
1) Is it possible to extract something like this with replacer parameter of JSON.stringify() ?
 {
  "fullName": "Don Corleone",


days, the estimated mean P(a)CO(2) in the normal group was significantly lower than in the congestion group (P<0.001). No significant differences were found between the P(a)CO(2) in the congestion and the haemorrhage groups. The findings might support a relation between a high P(a)CO(2) and congestion of the choroid plexus in the first three postnatal days and might be a sign of increased risk for a periventricular haemorrhage.couplings $u$ and $j$. Ultraviolet divergencies must be handled properly during this process. From the RG point of view, $j$ is an irrelevant coupling that scales to zero at the tree level. Still, along the RG procedure, it generates marginal terms $\propto u$, which renormalize $j$ itself, and can ultimately drive $j$ to strong coupling.

The leading order transformation can be read out directly from the structure of , yielding the linear terms in Eq. (3) of the main text. To capture the quantum phase transition, it is sufficient to restrict ourselves to second order terms, i.e. to one loop order. The relevant second order contractions are presented in Fig. .

![ Feynman diagrams for the second order corrections in the perturbative RG. Crossed lines indicate a logarithmic derivative with respect to


composite operator, $O^\dagger_\alpha =  j\; a^{N/2-1} D^\dagger \psi_N \dots \psi_{\alpha+1} \psi_{\alpha-1} \dots \psi_1$. Within the effective field theory, Eq. (2) in the main text, this operator corresponds to the operator $d_\alpha^\dagger$. For simplicity, let us focus on $O^\dagger_1$. In the bosonized form, this operator can be expressed as $j a^{-1/2}  D^\dagger\gamma_N\dots\gamma_2 e^{-i (\varphi_2+\dots + \varphi_N)}$. Next we introduce the charge field $\varphi_c \equiv \overline \varphi\cdot {\overline e}_c $ with ${\overline e}_c = \{1,1,\dots,1\}/\sqrt{N}$, and $N-1$ orthogonal and properly normalized spin fields, $\varphi_s^{(k)} \equiv \overline \varphi \cdot{\overline e}^{(k=1,..,N-1)}_{\;s} $ with the ${\overline e}^{(k)}$ denoting unit vectors orthogonal to ${\overline e}_c $ and to each other.

We can then rewrite the operator $O^\dagger_1$ as $$O^\dagger_1 = j \;a^{-1/2}  D^\dagger \gamma_N\dots \gamma_2 \exp\{-i (\frac {N-1}{\sqrt{N}} \varphi_c + q \;\tilde \varphi_s)\}
\label{eq:O}$$ with$q^2 =\frac{N-1}N$ and $\tilde  \varphi_s$ a properly normalized combination of the spin fields $\varphi_s^{(k)}$. Clearly, only the charge part of this operator is affected by the interaction terms in Eq. (5) in the main text.

By the optical theorem, the scattering cross section at energy $\omega$ is directly proportional to the imaginary part of the retarded self energy at that frequency. Therefore, we need to determine the low frequency behavior of $\Sigma_\alpha(\omega)$, related to the long time behavior of $\Sigma_\alpha(t)$. Since the coupling $j$ is irrelevant along the charge transition line, in leading order, we can set it to zero in Eq. (5), and then eliminate the term $\sim u$ by the unitary transformation $\tilde U= e^{i u \varphi_c(0) \sigma_z /2}$, transforming $O^\dagger_1$ into $$\tilde O^\dagger_1 \sim D^\dagger \gamma_N\dots \gamma_2


Cellular and Nuclear Forces: An Overview.
Biological cells sample their surrounding microenvironments using nanoscale force sensors on the cell surfaces. These surface-based force and stress sensors generate physical and chemical responses inside the cell. The inherently well-connected cytoskeleton and its physical contacts with the force elements on the nuclear membrane lead these physicochemical responses to cascade all the way inside the cell nucleus, physically altering the nuclear state. These physical alterations of the cell nucleus, through yet-unknown complex steps elicit physical and functional response from the chromatin in the form of altered gene expression profiles. This mechanism of force/stress sensing by the cell and then its nuclear response has been shown to play a vital role in maintaining robust cellular homeostasis, controlling gene expression profiles during developmental phases aswording is deliberate. He said adequate, not ideal. Even on a stage 2 car he stands to gain enough power with a good intake that will make the investment worthwhile. And he's not talking about whp, he's talking about crank. 400 chp is just a little over 300 whp.

I agree that he should try to return it. The SPT SRI is comparable to the stock airbox with the silencer removed until he makes a good bit more power, in which case the SPT is more restrictive than the airbox.

Quote:

Originally Posted by arcticscythe

If we want to talk about 400 whp builds there's plenty of space on the forums for that. To defend Fidrat, with proper supporting mods, turbo upgrade, and a proper tune you CAN achieve 400hp on the


bad example and spreading information that people might take the wrong way.

If you want to talk about making the impossible, possible I would love to have a theory conversation about the upper limits of open system compressors, poly carbonate housings stand alone engine management and the limits of synthetic media filters but that doesn't belong in this thread.

Hey fellas, I just wanted to say that I'm enjoying the intake fine "As cast" at the moment. The parts were quality except for some sketcht bolt threads. No issues. I took out the silencer in the fenderwell also.
I've read a lot about what the intake will and won't do.
My review-
Going form a stock set up, my engine can now breathe! My car felt like a wet rag on acceleration before.But the open intake has a crisp throttle feel now. I do love the whistle, and the pssh sound. It has more of a growl as well. And that's why I made this mod. For the trip up to the store or the side road launch, I like it. I got it for a very nice price at a Subaru dealer 165.
My next move..
For performance and durability, I'm replacing my stock up pipe with a catless one. I found a guy in my area who loves to work on these cars (He's got a WRX and an STI). Extremely nice dude and said he can slap it in in about 45 mins. I had to make him take money to do it. Anyway that's next.
I LOVE my 05


is a transformation of a block of residuals from the spatial (pixel) domain into a frequency domain. The transformation aims at reducing the correlation of the input block. Further encoding step is quantization of the transform coefficients. In this step the actual lossy (irreversible) compression takes place. Usually, the compressed transform coefficient values are further compacted (losslessly compressed) by means of an entropy coding. In addition, side information necessary for reconstruction of the encoded video signal is encoded and provided together with the encoded video signal. This is for example information about the spatial and/or temporal prediction, amount of quantization, etc.
FIG. 1 is an example of a typical H.264/MPEG-4 AVC and/or HEVC video encoder 100. A subtractor 105 first determines differences e between a current block to be507 F.2d 658
Dudley WIDEMAN, Administrator of the Estate of ClaudeWideman, Deceased, Plaintiff-Appellant,v.MISSISSIPPI VALLEY GAS COMPANY, Defendant-Appellee.
No. 73-3574.
United States Court of Appeals, Fifth Circuit.
Jan. 30, 1975.

William S. Lawson, John L. Long, Tupelo, Miss., for plaintiff-appellant.
John M. Kuykendall, Jr., Minor C. Summers, Jr., Jackson, Miss., Ralph L. Holland, Tupelo, Miss., for defendant-appellee.
Appeal from the United States District Court for the Northern District of Mississippi.
Before COLEMAN, CLARK and RONEY, Circuit Judges.
RONEY, Circuit Judge:

1
Claude Wideman was killed in an explosion and fire resulting when a small road grader he was operating on a private residential lot hit an underground gas line.  The outcome of this appeal turns on a determination of the standard of care owed to Wideman by the defendant gas company under Mississippi law.  The jury, instructed that


Q:

DOMPDF text is bolder than normal

I cant understand why the font color in DOMPDF is bolder than normal.
jsfiddle with the html
Image comparing HTML to DOMPDF:

Thanks for the help.

A:

As BrianS said, the cause for the problem is PNG 8 bit.
I made a function which converts all PNGs to JPGs and that solved the problem.
This is good if you don't which format it is > PNG or JPG.
Thanks BrianS.

comorbidities of metabolic syndrome. We therefore tested here whether n-3 polyunsaturated fatty acids (n-3 PUFAs) associated with a cocktail of antioxidants can protect against the development of behavioral alterations that accompany the metabolic syndrome. Thus, this study aimed: 1) to evaluate if a diet supplemented with the plant-derived n-3 PUFA α-linolenic acid (ALA) and antioxidants (provided by n-3 PUFAs-rich rapeseed oil fortified with a mix of naturally constituting antioxidant micronutrients, including coenzyme Q10, tocopherol, and the phenolic compound canolol) improved behavioral alterations in db/db mice, and 2) to decipher the biological mechanisms underlying this behavioral effect. Although the supplemented diet did not improve anxiety-like behavior and inflammatory abnormalities, it reversed hippocampus-dependent spatial memory deficits displayed by db/db mice in a water maze task. It concomitantly changed subunit composition


our debt."

Higher interest rates could force the annual debt-service bill to go up, laments the document. The debt load could inhibit the company's ability to get more financing and "heighten our vulnerability to downturns in business."

In my opinion, Petco would have been far better off attempting to retire its 1990s debt as it moderated its expansion spree and digested its prior rapid-fire acquisitions. The leveraged buyout only made the company more vulnerable to vicissitudes. Beware.

Then there's San Diego's hottest stock, FemOne of Carlsbad. It distributes nutrition, skin care, and cosmetics to women. For no apparent reason, its stock has zoomed from 15 cents early this month to around $1.45.

Instead of making a public offering for its stock, the company merged with a corporate shell that then changed its1. Introduction {#sec1-molecules-20-19675}
===============

In contemporary organic chemistry, the azide group is one of the functional groups that has received the greatest increase in attention over the last decades \[[@B1-molecules-20-19675],[@B2-molecules-20-19675]\]. In particular, the use of its orthogonal reactivity to other functional groups has led to a broad range of applications. Thus, cycloadditions with alkynes are routinely used in chemical biology \[[@B3-molecules-20-19675],[@B4-molecules-20-19675],[@B5-molecules-20-19675],[@B6-molecules-20-19675],[@B7-molecules-20-19675]\] and material sciences \[[@B8-molecules-20-19675],[@B9-molecules-20-19675],[@B10-molecules-20-19675]\]. While, in this context organic molecules with one azide group are widely accepted as standard entities, small molecules with two or more azide groups attached to the same carbon atom are quite uncommon. This lack of interest is at least a bit surprising, given the fact that reports on carbonyl diazide date back to 1894, and ethyl 2,2-diazidoacetate was described first in 1908 (see below).


warning:
-Wno-ignored-qualifiers

Hope this helps.

A:

Returning a constant value only makes sense when you return a reference or a pointer(in this case pointer to constant and not a constant pointer) because the caller is able to modify the referenced (pointed to) value.
Another comment on the code not related to your question:
I think it's better to use a setter instead of
int& getNonconstReference() {
    return _myInt;
}

Which will should be:
void setMyInt(int n) {
  _myInt = n;
}

Moreover, it's useless to return a const reference to an int. It does make sense for a bigger object whose copy or move is more expensive.

feel called to remain as
prophetic voices-and for the potluck suppers. Former church member Ima St.
Seime said, "I simply can no longer be part of a church where the Word and
will of the Almighty Lord my God is being blatantly ignored."

St. Seime, and others who have left over this issue, insist that
theirs is not a position of hate, but one of love for the righteous plan of
God. In a time of increasing acceptance of heterosexuality nationwide, many
anti-heterosexuals feel that those within the church who condone the
heterosexual lifestyle are merely succumbing to the secular values of our
age.

"This ludicrous position [pro-heterosexuality] cannot be founded on
anything but specious secular relativism," claims R.U. Wright, cousin of
Rev. Wright and president of Christians for Righteous and Appropriate
Partnerships.

Members of CRAP cite numerous biblical passages to support


with an upper respiratory. They could not breath at one point. They would not eat anything so we had to force feed them. This was the food the vet told us to feed them. After about two months of dealing with their sickness, they got better. Sadly they didn't get adopted til they were almost a year oldJune 23 is the 30th anniversary of the great global warming scare. The scare began in Washington, DC, on this day in 1988 when testimony by a then little-known scientist called James Hansen before the Senate Committee on Energy and Natural Resources caught headlines across the world.


Those of us even sparsely active on social media must have at some point of scrolling through an ocean of posts come across images of Indian army soldiers, with the caption – “share if you are a true Indian”. The not-so-subtle nudge at our patriotism gets us to do as intended and the post goes viral; rarely do we wonder that the image might have an ulterior motive.

A thriving business

They say sharing is caring and a closed Facebook group by the same name seems to live the thought on a daily basis. The group asks for a government ID proof if you wish to join it and once you’re inside the circle of over 18,000 individuals, you can buy or sell patriotism, misogyny, politics, Bollywood, nationalism and evenFacebook and Youtube videos.

9. Fake offer websites

Alt News had recently published a story on fake government offers doing rounds on WhatsApp, claiming that the prime minister is giving away free helmets and bicycles. The message included a link that opened up a form, which asked for your personal details, including residential address. The one-page form had at least two Google ads. Last year, another WhatsApp forward claimed that Prime Minister Narendra Modi was giving free balance. This too redirected users to a form that asked for their name, phone number, mobile service operator and the state of residence.

We found similar websites selling on Sharing is Caring.

There were many others too offering websites with fake Paytm offers and Patanjali SIM cards.

While at face value such websites might seem harmless,


Amendment rights.
The Michigan trial court granted his motion. On interlocutory review, the Michigan Court of Appeals reversed, relying *589 on Michigan Supreme Court cases holding that suppression is inappropriate when entry is made pursuant to warrant but without proper "`knock and announce.'" App. to Pet. for Cert. 4 (citing People v. Vasquez, 461 Mich. 235, 602 N. W. 2d 376 (1999) (per curiam); People v. Stevens, 460 Mich. 626, 597 N. W. 2d 53 (1999)). The Michigan Supreme Court denied leave to appeal. 465 Mich. 932, 639 N. W. 2d 255 (2001). Hudson was convicted of drug possession. He renewed his Fourth Amendment claim on appeal, but the Court of Appeals rejected it and affirmed the conviction. App. to Pet. for Cert. 1-2. The Michigan Supreme Court again251 U. S. 385 (1920); Mapp, supra, say nothing about the appropriateness of exclusion to vindicate the interests protected by the knock-and-announce requirement. Until a valid warrant has issued, citizens are entitled to shield "their persons, houses, papers, and effects," U. S. Const., Amdt. 4, from the government's scrutiny. Exclusion of the evidence obtained by a warrantless search vindicates that entitlement. The interests protected by the knock-and-announce requirement are quite differentand do not include the shielding of potential evidence from the government's eyes.
*594 One of those interests is the protection of human life and limb, because an unannounced entry may provoke violence in supposed self-defense by the surprised resident. See, e. g., McDonald v. United States, 335 U. S. 451, 460-461 (1948) (Jackson, J., concurring). See also Sabbath,


apart from the requirement of unattenuated causation, the exclusionary rule has never been applied except "where its deterrence benefits outweigh its `substantial social costs,'" Scott, 524 U. S., at 363 (quoting Leon, 468 U. S., *595 at 907). The costs here are considerable. In addition to the grave adverse consequence that exclusion of relevant incriminating evidence always entails (viz., the risk of releasing dangerous criminals into society), imposing that massive remedy for a knock-and-announce violation would generate a constant flood of alleged failures to observe the rule, and claims that any asserted Richards justification for a noknock entry, see 520 U. S., at 394, had inadequate support. Cf. United States v. Singleton, 441 F. 3d 290, 293-294 (CA4 2006). The cost of entering this lottery would be small,to physical abuse at the station house, would it seriously be suggested that the evidence must be excluded, since that is the only "effective deterrent"? *597 And what, other than civil suit, is the "effective deterrent" of police violation of an already-confessed suspect's Sixth Amendment rights by denying him prompt access to counsel? Many would regard these violated rights as more significant than the right not to be intruded upon in one's nightclothesand yet nothing but "ineffective" civil suit is available as a deterrent. And the police incentive for those violations is arguably greater than the incentive for disregarding the knock-and-announce rule.
We cannot assume that exclusion in this context is necessary deterrence simply because we found that it was necessary deterrence in different contexts and long ago. That


practical implications, adding to the list of issues requiring resolution at the criminal trial questions such as whether police officers entered a home after waiting 10 seconds or 20.
In this case the relevant evidence was discovered not because of a failure to knock and announce, but because of a subsequent search pursuant to a lawful warrant. The Court in my view is correct to hold that suppression was not required. While I am not convinced that Segura v. United States, 468 U. S. 796 (1984), and New York v. Harris, 495 U. S. 14 (1990), have as much relevance here as Justice Scalia appears to conclude, the Court's holding is fully supported by Parts I through III of its opinion. I accordingly join those Parts and concur inof that evidence would seriously undermine the Fourth Amendment's promise. All three cases recognized that failure to apply the exclusionary rule would make that promise a hollow one, see Mapp, supra, at 657, reducing it to "a form of words," Silverthorne, supra, at 392, "of no value" to those whom it seeks to protect, Weeks, supra, at 393. Indeed, this Court in Mapp held that the exclusionary rule applies to the States in large part due to its belief that alternative state mechanisms for enforcing the Fourth Amendment's guarantees had proved "worthless and futile." 367 U. S., at 652.
Why is application of the exclusionary rule any the less necessary here? Without such a rule, as in Mapp, police know that they can ignore the Constitution's requirements without risking


by many States, by diminishing uncertainty, may make application of the knock-and-announce principle less "`cost[ly]'" on the whole than application of comparable Fourth Amendment principles, such as determining whether a particular warrantless search was justified by exigency. The majority's "substantial social costs" argument is an argument against the Fourth Amendment's exclusionary principle itself. And it is an argument that this Court, until now, has consistently rejected.

III
The majority, Michigan, and the United States make several additional arguments. In my view, those arguments rest upon misunderstandings of the principles underlying this Court's precedents.

*615 A
The majority first argues that "the constitutional violation of an illegal manner of entry was not a but-for cause of obtaining the evidence." Ante, at 592. But taking causation as it is commonly understood in the law,inevitably would have been discovered by lawful meanshere the volunteers' searchthen the deterrence rationale has so little basis that the evidence should be received").
Segura's police officers would have been foolish to have entered the apartment unlawfully with the ex ante hope that an independent causal chain of events would later occur and render admissible the evidence they found. By way of contrast, today's holding will seriously undermine deterrence in knock-and-announce cases. Officers will almost always know ex ante that they can ignore the knock-and-announce requirement without risking the suppression of evidence discovered after their unlawful entry. That fact is obvious, and this Court has never before todaynot in Segura or any other post-Weeks (or post-Mapp) caserefused to apply the exclusionary rule where its absence would so clearly and


of privacy in his house." Miller, 357 U. S., at 313; cf. Harris, 495 U. S., at 17 ("Payton itself *628 emphasized that our holding in that case stemmed from the `overriding respect for the sanctity of the home that has been embedded in our traditions since the origins of the Republic'"). Like the confession that was "excluded, as it should have been," in Harris, id., at 20, the evidence in this case was seized in the home, immediately following the illegal entry. And like Harris, nothing in petitioner's argument would require the suppression of evidence obtained outside the home following a knock-and-announce violation, precisely because officers have a remaining incentive to follow the rule to avoid the suppression of any evidence obtained from the very place theyestablishing several major practice centres, over one hundred meditation centres, and Naropa University.

Lineage Holder

Eva Wong, author and translator of thirteen books on the Taoist arts of health, meditation and Qigong, is the 19th-generation lineage carrier of Xiantianwujimen Taoism (Pre-celestial Limitless Gate School of Taoism) and 3rd-generation student of Wang Xiangzhai, founder of Yiquan martial arts and Zhangzhuan (standing Qigong).

Onyumishi Kanjuro Shibata is a 20th generation master bowmaker and archer and 3rd generation "Bowmaker to the Emperor of Japan" (retired).

In 1980, by the invitation of The Venerable Chogyam Trungpa Rinpoche, a Tibetan meditation master, and founder of Shambhala International and Naropa University, Kanjuro Shibata XX came to the United States from Japan to teach Kyudo and together with Trungpa, founded Ryuko Kyudojo (Dragon-Tiger Kyudo Practice Hall) in Boulder, Colorado.

Acharya

Acharya


due to the promise to expose low contributors, high contributors or both. If players know that only the least or most cooperative individuals are to stand in front of their peers, will they cooperate more as a group?

We designed this public goods experiment to isolate the effects of being shamed or honoured, with no monetary consequences to either experience, and test whether the expectation of negative or positive reputational information enforces social behaviour. We hypothesized that the threat of shame or the prospect of honour would lead to increased public contributions. We also expected that shame might be more effective than honour because players would particularly seek to avoid negative exposure, and therefore contribute more to the public good.

2.. Material and methods {#s2}
========================

We tested our predictions with 180first-year University of British Columbia science students divided into three treatments, shame, honour and control, consisting of 10 identical six-player games each. To foster indelibility of being shamed and honoured, all six players came from the same class so that the players were acquainted with each other. Players were recruited within the first few weeks of the term to ensure that they would meet again repeatedly during the term.

There was a single group of six players in the room at a time. Players were partitioned off from each other as well as the experimenters, who stayed out of view for the duration of the actual experiment. Each player received a starting account of CDN\$12 and a randomly assigned unique pseudonym (obscure Greek gods). Players were anonymized, both to


with the names of the four players that retained their anonymity were visibly destroyed and discarded in front of the group. In the control treatment, all six players remained anonymous. At the end of round 12, each player left with the money he/she kept during the game plus the profits from the public pool. Note that the profits from the public pool were the same for every player and could therefore be distributed without compromising the players\' anonymity. The students were asked not to discuss the experiment with anyone else.

3.. Results {#s3}
===========

In each treatment, initial cooperation in the public goods game declined as expected (paired *t*-test between 1st and 10th round, *n*~s~ = 10, *t* = 2.71, *p* = 0.024; *n*~h~ = 10, *t* = 4.61, *p* =hormone productions to also follow trends concomitant with steroidogenic enzyme gene expressions. General trends predicted by in silico modeling were similar to those observed in vivo. The integrated computational framework presented was capable of mechanistically representing aspects of reproductive function in fish. This approach can be extended to study reproductive effects under exposure to adverse environmental or anthropogenic stressors.


work with,” Vossler said. “I’ve been around long enough that there’s a certain amount of trust among the members. It’s a good group to work with.”

Looking back on his time on council, Vossler said the development around the Miami and Erie Canal and the construction of a new wastewater treatment plant stood out in his mind of key developments for the city.

“We’ve upgraded the parks,” Vossler said. “We’ve extended city services and made improvements along McKinley Road and of course all the new businesses. There’s been a lot that has happened in the last 18 years and it’s been a good run and I am sure things will keep going in the right direction.”

Vossler also offered some advice to his successor.

“Don’t come in with an agenda,” Vossler said.Mountain Business Park off Highway 108 for this business.  Land development: A tertiary (stand-alone single lot) land disturbance permit was issued in the Hampton Farms subdivision off Parker Rd. A tertiary permit was issued in The Village at Oak Creek subdivision off Highway 53 West. The preliminary plat for phase 2 of The Ranches at Town Creek subdivision in northwest Pickens was approved.

Alcohol Based on an analysis of 2017 county alcohol license holders, the highest alcohol sales were reported by license holders in East Pickens: Foothills IGA, Big Canoe, and Home Restaurant.

Permits & Inspections Notes Planning & Development is glad to welcome back Willie Fortner as the Certified Building Official for commercial and industrial projects. Richard Bruce continues to do a great job as the Certified Building


John Vickers
 1686–1696 John Hoyland
 1696–1748 Samuel Martin
 1748–1773 Thomas Parkinson
 1773–1792 Thomas Hadwen
 1792–1811 Edward Shaw
 1811–1813 John Morgan
 1813–1844 Thomas Stevenson
 1852–1860 John George Gordon
 1860–1875 James Wallace
 1876–1893 John Brise Colgrove
 1894–1900 Cecil William Kaye
 1901–1920 Bingham Dixon Turner
 1920–1926 Tom Stinton
 1926–1955 Sidney Russell Pullinger
 1955–1959 Walter Lucian Garstang
 1959–1973 Norman Sydney Walter
 1973–1984 John Scandrett Millward "Hench"
 1984–1998 (David) Neville Ireland
 1998–2015 Paul B Fisher
 2016 – present Duncan J Byrne

Old Loughburians

Old boys of Loughborough Grammar School are called "Old Loughburians". They form an old boys' association, namely the Old Loughburians Association (commonly OLA).

Notable Old Loughburians include:

 Sir Thomas Abney (1640–1721), merchant, Lord Mayor of London and Member of Parliament.
 Richard Pulteney FRS (1730–1801), botanist.
 Thomas Green (1738–1788), geologist, Woodwardian Professor of Geology.
 myWD.init();

    PID = fork();

    if (PID == 0) {
        // proc1
        proc1 = getpid();

        myWD.register(proc1);

        while (true) {
            semaOne->take();

            std::cout << "[PROC 1] here" << std::endl;
            // per1form proc1 task here and TICK the watchdog
            myWD.tick(proc1);
            usleep(2000000);


celebrating the news of potentially becoming a parent soon.

Baseball star Jose Fernandez departed from this world before he could attain the joy of welcoming his offspring who was born a few months after his death.

Fernandez's life certainly wasn't straightforward as it was only revealed after he died that he, in fact, was married and divorced, as well as broke off his engagement with his fiance after an affair with then-future mother of his child.

Jose Fernandez Died Aged 24 In 2016

Former Miami Marlins pitcher Jose Fernandez was killed in a boating accident in Florida on 25th September 2016. The news was confirmed by the Marlins.

Jose Fernandez Died Aged 24 In 2016

Source: Radar Online

Major League Baseball commissioner Rob Manfred said in a statement:

"All of baseball is shocked and saddened byinter alia, freshwater wetlands that were periodically inundated and which supported vegetation that requires saturated soil conditions.   See United States v. Riverside Bayview Homes, Inc., 474 U.S. 121, 106 S.Ct. 455, 457, 88 L.Ed.2d 419 (1985);  33 C.F.R. Sec. 209.120(d)(2)(h ) (1976).  In 1977, the Corps further extended its jurisdiction over wetlands by eliminating the requirement that the wetland be periodically inundated, requiring only that it be inundated or saturated by surface or groundwater at a sufficient frequency to support vegetation adapted for life in saturated soils.  Id. at 458;  33 C.F.R. Sec. 323.2(c) (1978).  In Riverside Bayview Homes, the Supreme Court upheld the Corps' expanded view of its regulatory authority over freshwater wetlands under the Clean Water Act.


dredged or fill material into the following waters of the United States are hereby permitted for purposes of Section 404, provided the conditions in paragraph (b) below are met:

19
(1) Non-tidal rivers, streams and their impoundments including adjacent wetlands that are located above the headwaters;

20
....

21
(b) For the purposes of Section 404, the following conditions must be satisfied for any discharge of dredged or fill material in waters described in paragraph (a) above:

22
....

23
(3) That the fill created by the discharge will be properly maintained to prevent erosion and other non-point sources of pollution....

The term "headwaters" is defined as

24
the point on a non-tidal stream above which the average annual flow is less than 5 cubic feet per second.  The District Engineer may estimate this point from available data using thesecond.  Manley's own testimony suggested that simple mathematics alone was insufficient to fix that point.  He testified that to do so would require study of the topography maps to determine drainage patterns.

28
Since Cumberland is seeking to qualify under this exception to the individual permit requirement, it had the burden of persuading the court of the applicability of the headwaters permit.   See Riverside Irrigation District v. Andrews, 758 F.2d 508, 514 (10th Cir.1985) (one seeking to qualify under nationwide permit must show that conditions for permit exist).  Cumberland did not present any expert testimony to assist the court in applying the mathematical formula, to locate on a map the point where each stream fell below the threshold flow level, and to delineate what wetlands


work completed before 18 December 1968 or in waterbodies over which the District Engineer was not asserting jurisdiction at the time the activities occurred provided, in both instances, there is no interference with navigation.

48
Thus the recodification of this permit did not expressly state that it applied only to section 10 of the River and Harbor Act.  The omission of such a statement leads to Cumberland's present argument that, given the introductory section set out above, the permit applied to activities regulated under both statutes, since the recodified permit does not state otherwise.

49
The Corps replies that the unasserted jurisdiction permit was simply moved to the new part 330, without any intention that substantive changes be made, and that the permit continued to apply only to section 10 ofinterest by balancing the favorable and detrimental impacts of a proposed activity.  See 33 C.F.R. Sec. 320.1(a).  Cumberland asserts that such a balancing of public interests can be best accomplished through an after-the-fact permit process.

61
The regulations that Cumberland points to as evincing a policy of public participation through an administrative hearing are primarily concerned with permit applications for proposed projects that will occur in wetlands.7   The present circumstances do not easily fit within the frame of a proposal stage proceeding.  In the latter, there is more time to solicit public input and to weigh competing values before authorization of the proposed project.  Here, there was a serious, ongoing violation of the Clean Water Act, as to which the Corps' regulations, found at


part 326, "Enforcement, Supervision and Inspection," are more on point.  Under part 326, the regulations make it clear that the Corps will consider an after-the-fact permit only if the violator has completed interim remedial work which the Corps deems necessary to protect public resources.  In the present case, Cumberland refused to comply with the Corps' interim remedial order, which was designed to restore the area to its 1977 wetland condition, "unless and until some higher authority determines that to be an appropriate result."    Therefore, the Corps refused to consider an after-the-fact permit for Cumberland's activities.

62
The Corps' enforcement regulations' subsection entitled "Administrative action" states,

63
Remedial work.    (1) The district engineer shall determine whether as a result of the unauthorized activity, life, propertyor important public resources are in serious jeopardy and would require expeditious measures for protection.  Such measures may range from minor modification of the existing work to complete restoration of the area involved....  If the district engineer determines that immediate remedial work is required, he shall issue an appropriate order describing the work, conditions and time limits required to provide satisfactory protection of the resource.

64
33 C.F.R. Sec. 326.3(b).  Thus the district engineer is expected to issue such remedial orders as he deems necessary, and such orders may range, as necessary, from minor modifications to complete restoration of the wetland, which was the case here.

65
Under the subsection entitled "Acceptance of an after-the-fact application," 33 C.F.R. Sec. 326.4(c), the regulations clearly require that remedial work be completed


the area converted since 1977, the restoration order places a heavy burden on Cumberland.  However, Cumberland has no one but itself to blame for that burden.

81
Had Cumberland complied with the Clean Water Act when the Act first became applicable to its activities in 1977, no such burdensome order reversing the many years of illegal activity would have been necessary.  Moreover, Cumberland's intentional, unlawful conversion activities continued even after the Corps actively tried to get Cumberland's cooperation in complying with the law.  We believe the district court did not err in finding that the restoration order bore an equitable relationship to the degree and kind of wrong which it is intended to remedy.

82
Affirmed.

*
 Of the United States Court of International Trade, sitting by designation

1
 The districtof erosion--not merely some "minor" amount as Cumberland claims--was occurring from Cumberland's activities.  There was ample evidence, in the form of testimony and pictures, to support the court's finding of "significant" erosion

5
 According to Cumberland's own representations, it did no dredging and filling at the site between the summer of 1983 and 1985.  Since the ambiguous rule was promulgated in July of 1982, only a year's activity at most could have occurred under the purportedly permissive rule

6
 Throughout this enforcement action Cumberland has not asserted, nor has it pointed to, any statute of limitations which might preclude enforcement of the Clean Water Act

7
 While primarily designed for proposed projects, these same regulations do apply to an after-the-fact permit process.  However, as the regulations make clear,


the firm name of the De Vries Auction Company.
The defendant is a Minnesota corporation engaged in selling livestock on the market at South St. Paul as a commission merchant and is licensed as a market agency under the Packers and Stockyards Act, 42 Stat. 159, 7 U.S.C.A. § 181 et seq.
Tobias Brackey, not a party to this action, was involved in the transaction as he purchased the cattle in Iowa from the plaintiffs and marketed them in Minnesota through the defendant. Brackey purchased the cattle on April 18, 1950, at an auction held by the plaintiffs for a consideration of $5,567.77 and gave his check on a Lake Mills, Iowa, bank in payment. The sale by the plaintiffs to Brackey was a cash transaction. They had sold livestockthey may look to the defendant in an action for conversion. In effect, the sole question in the case is who shall bear the loss.
The plaintiffs contend: (1) That where property is sold and a check is given in payment such payment is conditional and delivery of title to the property likewise is conditional; (2) that if the check is dishonored title to the property does not pass to the purchaser and anyone not a bona fide purchaser in good faith acting in derogation of the seller's title is guilty of conversion; (3) that a livestock commission merchant or factor is not a bona fide purchaser; and (4) that the Packers and Stockyards Act does not alter his position.
The defendant contends: (1) That where one of two innocent


2017

The New Hampshire Democratic Party released a statement that celebrated their historic victory:

If I’m the Republican Party, I’m looking at this result combined with very close race in the Montana special House election, and the Democrat leading the special election in Georgia, and I am very worried. Republicans lost a seat tonight that they have never lost before. It is looking more and more like the New Hampshire won’t be their only historic defeat in 2017.

The Resistance is real, and the results are beginning to show as Democrats have flipped their first seat of the Trump presidency.West Nile virus in the Americas.
Since the first detection of West Nile virus in the Western Hemisphere in 1999, the virus has spread rapidly across the North American continent and as far south as Argentina. An unprecedented pattern of large annual epidemics of human neuroinvasive disease continues in North America, resulting in considerable public health impact. The high infection incidence in humans has resulted in non-mosquito transmission modes, such as through transfused blood and transplanted organs. West Nile virus incursion into Latin America and the Caribbean Islands has resulted in surprisingly low human, avian, and equine morbidity and mortality despite evidence that West Nile virus strains circulating in those regions are similar to those in North America.


file, but my brain starts to fry, as I try figuring out how to use that info to rename the files, by date created, picking up from the last properly named file.
I definitely appreciate any help!

I did a lot of work on this. I got help and did a lot of reading. This solution is probably rough in some areas, but it does the job and can run in the background to perform actions automatically - with one caveat: the Powershell console must be left open.
I haven't figured out how to make this a permanent WMI event binding.
Solution:
#REQUIRES -Version 4.0

#This is a string of folders you'd like to monitor
$Monitored = 'C:\Users\Me\Desktop\Pic Test\Tom Hiddleston', 'C:\Users\Me\Desktop\Pic Test\Kate Bosworth'

#This part is selecting the folder paths to be processed indvidually
$MatchPath = @($Monitored#Selects which file extentions to include in renaming
    Filter Where-Extension {
    Param( [String[]] $Extension = ('.bmp', '.jpg', '.png', '.gif', '.jpeg', '.avi')) $_ |
    Where-Object { $Extension -contains $_.Extension }}

    #Orders all the files by their CreationTime
    Function Global:File-Order ($Local) {Get-ChildItem -Path $Local |
    Where-Extension .jpg,.bmp,.png,.jpeg,.gif,.avi |
    Select-Object Name,FullName,CreationTime|Sort-Object -Property CreationTime}

    #Returns a file's extension
    Function Global:File-Ext ($File) {Get-ItemProperty $File| Select-Object -Expand Extension}

    #Returns the name the file should be - the NewName
    $NewBase = ((Split-Path $Local -Leaf) + '_{0:d2}{1}' -f  $i, $Ext).Split("\.")

    File-Order ($Local) | ForEach-Object -Begin {$i = 0}


`
    -Process {
        $Ext = File-Ext ($_.FullName)
        $NewName = $NewBase[0] + $i

        if (!(Test-Path (-Join ($Local,'\',$NewName,'.*'))))
        {Rename-Item -Path $_.FullName -NewName (-Join ($NewName,$Ext))}
        $i++ }
        };

$FileAction = Register-ObjectEvent -InputObject $Watcher Deleted -SourceIdentifier FileDeleted_$ID -Action  {

    $Local = Split-Path ($Event.SourceEventArgs.FullPath)
    $i = 0

    #Selects which file extentions to include in renaming
    Filter Where-Extension {
    Param( [String[]] $Extension = ('.bmp', '.jpg', '.png',hurdles, such as finding investors and hiring staff, Ella had to overcome some classic Indian obstacles: a byzantine and often corrupt bureaucracy, strike-prone labor unions, and government interference.

On arriving in his native country, though, Ella's first problem was money. He had collected a million dollars from friends and colleagues at the Medical University of South Carolina, where he'd taught for a decade. But then the offer of a loan from Indian investors fell through soon after his arrival in India.

As a result, Ella and his wife had to spend the first months convincing banks to loan them money. It didn't help that Ella was a repatriate. "Nobody could understand why someone would come back to India," Ella says. "Everyone's first question was: 'What went wrong in America? Did


increases in uptake during summer months. The earlier peak for MPSV4 suggests that different factors may play a role; however, given the small number of MPSV4 vaccinations (compared to Td and MCV4), it is difficult to hypothesize possible reasons. It is possible that MCV4 would have peaked in August (before the start of school), like Td, if not for the vaccine limits placed by the manufacturer (in July). Michigan\'s vaccine registry data showed a similar surge in MCV4 uptake during summer months suggesting that this seasonal increase is not limited to adolescents enrolled in managed care \[[@B21]\]. The GBS investigation was announced on September 30, 2005, and by then vaccine uptake had declined substantially. Although we cannot ascertain whether the decline between September and October was related toolds and preferentially vaccinate college freshman. School immunization laws have had a marked impact on both the incidence of vaccine preventable disease and immunization coverage in the United States. A limited number of studies suggest that much of the success of adolescent immunization programs in the United States is a direct result of these requirements\[[@B16],[@B23]\]. During our study period, none of the MCOs were affected by statewide MCV4 legislation (Table [1](#T1){ref-type="table"})\[[@B24]\].

In February 2005, the ACIP carefully considered supply, anticipated demand and disease epidemiology when recommending routine use of MCV4 for adolescents 11-12 and 14-15 years of age\[[@B25]\]. At the same meeting, the manufacturer projected producing about 5 million doses in 2005\[[@B26]\] and the 2005 CDC Annual Biosurveillance data (CDC unpublished data) show that the manufacturer reported distributing about


in histone H4 and is strongly correlated with the active states of the genes ([@bib11]; [@bib26]; [@bib44]). Chromatin immunoprecipitation experiments have shown that histone H4 is hyperacetylated in the promoter regions of active genes ([@bib23]; [@bib7]; [@bib29]; [@bib36]). Experiments of this type have also shown that lysines 9 and 14 on histone H3 (H3/K9 and H3/K14, respectively) are acetylated in the promoter region when the gene is activated ([@bib4]). Recently, it has been demonstrated that distinct histone modification patterns function as recognition codes for the recruitment of different transcription factors upon transcriptional activation ([@bib4]). The acetylation of H4/K8 is involved in the recruitment of the SWI/SNF complexes to chromatins, whereas the acetylation of H3/K9 and H3/K14 is required for the recruitment of transcription factor IID. Thus, the histoneproduction of cloned animals has shown that the cytoplasm of MII-stage oocytes is able to reprogram the gene expression patterns of the transferred somatic nuclei ([@bib51]; [@bib49]; [@bib31]). In our study, the histone acetylation levels decreased markedly in the somatic nuclei that were transferred into the enucleated oocytes ([Fig. 5](#fig5){ref-type="fig"}).

When differentiated cells proliferate, the information on the active genes is transmitted faithfully to the daughter cells, thereby maintaining the lineage-specific program of gene expression in the descendent generations. As most of the transcription factors are displaced from the chromosomes and the genes are silent during mitosis ([@bib13]; [@bib24]), it has been suggested that a mechanism exists to maintain the lineage-specific program of gene expression. This mechanism is called "cell memory" ([@bib50]; [@bib32]), and it suggests that certain epigenetic


their team, and use strategic insights to keep their recruiting competitive. From candidate sourcing with 160 million talent profiles, to discounted posting, automated screening, grading and interview scheduling, to easily building talent pools, EEO/OFCCP compliance reporting and much more, ClearCompany gives you everything you need to find, hire and engage "A Players."
Learn more about ClearCompany

by INTELIFI

Intelifi is an Accredited Background Check Company servicing Employment Background Checks Nationwide to 5,000+ Companies including Staffing Agencies, Healthcare and Human Resources. Our proprietary software, EMERGE is in its 5th generation and has become a leading Pre-Employment Screening Software in the industry. With over 40 various data vendors, Several ATS integrations, and a strong team of senior developers, Emerge has been recognized by the NAPBS as a leading background screening provider
Learn more aboutabout Employee Surveys

by Smarp Oy

Smarp Employee Communication App is a content hub for organizations internal and external content. Smarp helps employees build their thought leadership and networks, and to stay up to date with their company and industry news by making it easy for them to discover, share and measure the impact of great content.
Smarp's native mobile apps enable companies to push content directly to their employees smartphones, making sure employees are always well informed and up to date.
Learn more about Smarp

by Zunos

Zunos is a digital learning platform built to offer a blended learning and training experience to your employees and partners. Create engaging, interactive learning content and assessments with our built-in authoring tool. Deliver information in bite-sized pieces, then target that information to the people who need


are based on industry standards and make sure every aspect of your company is covered.

by YouEarnedIt

YouEarnedIt is the employee experience platform powered by the science of motivation and the mission of improving the lives of employees everywhere, one company at a time. Our company and technology are built on the four pillars of employee experience: connection, meaning, impact, and appreciation. Request a demo: http://www.youearnedit.com/demo.

by Reflektive

by Thymometrics

The world's leading always-on real-time engagement & 2-way anonymous feedback solution. Instant dashboards, trend monitoring & deep dive reports are always available on any device to genuinely track mood changes across your organization & enable you to take appropriate actions. Our simple to use solutions ensure you don't miss a beat of your organizations pulse. Exciting to use, Thymometrics gives you real-time insightto engage employees (77%+) and reduce costs for employers. Using the science of micro-behaviour coaching, we provide a mobile-first experience for employees. Optimity apps sync with your current routines (calendar, other apps, wearables, etc.) to form small, healthy micro-habits that help you live happier and longer. HR leaders use the Optimity administrator panel to launch Health Risk Assessments and report ROI.

by 6Q

6Q provides detailed analysis on how your employees feel about topical company culture and engagement topics, through our award winning six question polls, which take less than two minutes to complete. See our website for a free 25 day trial.

by MangoApps

A team collaboration and a company social intranet product that transforms company communications, makes working lives simpler, pleasant and more productive by providing all collaboration tools in


unifies HR processes and workflows like leave approvals, vacation requests, POs etc by integrating with systems like as SharePoint, SAP, Oracle, O365, Salesforce.

by Tabsurvey

tabsurvey is the feedback system for companies that take customer opinion and feedback seriously. Collect feedback from 1,000 locations or through online. tabsurvey has great usability, stores data safely and measures continuously. Drop the biannual surveys and instead monitor and collect data in an continous stream - It is more accurate plus it is easy, as tabsurvey is designed for it. Tabsurvey gives your the correct picture of how your business is performing today rather than the past.

by hubEngage

by Vocoli

Vocoli is a firm focused on making a better workplace through ideation and innovation programs. Through our digital suggestion box, we help companies engage their teams,peoples feelings on different topics in your organization. It's never been this easy to pick up weak signals, to stay in the loop with ongoing topics, and solicit feedback anytime, anywhere. With Apped Pulse anyone can anonymously record and share their general mood or feelings over specific topics. Start a topic, match your mood, and share to your co-workers.

by Moodwonder

by Limeade

Limeade is a corporate wellness technology company that drives real employee engagement for large enterprise clients. Limeade takes a whole-person approach to well-being, amplifies an organizations commitment to its employees and delivers smart technology that fits how people work today. Employees earn points and rewards for taking steps to improve, while employers experience better business results.

by Questis

Questis is the only a comprehensive financial wellness platform built for the


data, and automate processes as a service within a larger application, airSpring provides an opportunity for businesses to more quickly modernize the user experience and engage customers.

by Boost Rewards

Ignite allows your organization to recognize employee achievements on a social peer-to-peer platform, stay up-to-date through an interactive newsfeed, and get real-time updates about your company. This empowers individuals to build a more connected workforce.

by SmartSimple

SmartSimple Employee Giving is an all-in-one solution that streamlines every step in your corporate volunteering, donation, and matching programs. Align your company's values with the generosity of your most important asset your people.

by Employee Wow

Enterprise management software for anonymous customer/employee feedback including iPad, iPhone, SnapChat and email signature software. Use our software to improve productivity and gain insight to your business. Hear from employees andNew fruitage

New fruitage

For many years I was underweight. This condition often brought suggestions of material remedies and much human sympathy from well-meaning family and friends.

As a Christian Scientist, I began to challenge and silently refute these suggestions, claiming my perfection as the image and likeness of God. I persisted in declaring, that as a spiritual idea in Mind, I was neither underweight nor overweight—that there could be no lack and no surplus. Particularly helpful was Mary Baker Eddy’s reference to the Christ child on page 167 of Miscellaneous Writings: “He is wholly symmetrical.” This enabled me to better understand that man is a symmetrical idea. Reasoning further, I joyously concluded that I would manifest whatever weight was “right for me,” not that established by mortal mind according to


material tables, charts, and scales.

Since beginning my study of Christian Science, I have never been weighed on a scale, and so cannot give the number of pounds involved; but during the time it took to make this demonstration, my body assumed new proportions and it was necessary for me to wear dresses three sizes larger than I had been wearing previously.

I think this experience can best be summarized by the following statement in Science and Health: “Consciousness constructs a better body when faith in matter has been conquered.” (425:23-25)a Vice President, especially with two hot girls fighting over you, right?

The game is mostly a comedy and makes jokes ranging from video games, anime, and visual novels to parodying the names of current presidents. For example, your neighbor the president is named Yukino Ohama, making reference to Obama, and the Russian president is Irina Vladimirovna Putina, a reference to Vladimir Putin. There is a reference to Bush as well; in a getaway scene where you and Yukino get on segways to escape from a crowd, she falls and you say “Ah, as I thought, a president is destined to fall off when they get on this.” The game references other popular culture too including Pokemon, Metal Gear Solid, Yu-Gi-Oh, Gurren Lagann and more. They even joke about


again.

The Ugly

Taking one point out of nine to start the season is not ideal to say the least. However, Orlando City started last season with six out of nine points in the first three matches, and yet the the Lions finished 10th in the Eastern Conference. Might it be that early results don’t necessarily predict how a team finishes in the end? Ah yes, I haven’t told you the “Ugly” yet. I think it’s those fans who are giving up so soon. I understand the frustration. Orlando City made a ton of moves in the off-season, including some big names like Sacha Kjlestan, and Justin Meram. Along with the other moves made, expectations were high for the season. The mentality for both the supporters and the organization isInstead, the touchstone for “substantiality” is
whether allowing state courts to resolve the case would un-
dermine “the development of a uniform body of [patent]
law.” Vermont v. MPHJ Tech. Invs., LLC, 803 F.3d 635,
646 (Fed. Cir. 2015) (quoting Gunn, 568 U.S. at 261).
Therefore, we consider “the importance of the issue to the
federal system as a whole.” Gunn, 568 U.S. at 260.
    Adopting our sister circuit’s framework, we recently
concluded that the Supreme Court had identified three fac-
tors that inform this substantiality inquiry. NeuroRepair,
781 F.3d at 1345 (citing MDS (Can.), Inc. v. Rad Source
Techs., Inc., 720 F.3d 833, 842 (11th Cir. 2013)). A “sub-
stantial federal issue is more likely to be present” if:
    a) “a pure issue of [federal] law is dispositive of the


a
broad categorical rule for what was sufficient to satisfy
“arising under” jurisdiction, Forrester held that the allega-
tions at issue failed to raise a substantial issue. Id. at 1336
(concluding “patent law issues are not ‘substantial in the
relevant sense’ under Gunn” (quoting Gunn, 568 U.S. at
260)).
    Moreover, to the extent that Forrester and Hunter
Douglas discussed claims that might raise a substantial is-
sue, the allegations involved fundamentally different
claims. Forrester concerned claims for business disparage-
ment (e.g., suits alleging false or inaccurate statements
about patent rights). Id. at 1334. In Forrester, we noted
that “[i]n the past,” we have “concluded that similar state
law claims premised on allegedly false statements about
patents raised a substantial question of federal patent
20       INSPIRED DEVELOPMENT GROUP v. INSPIRED PRODUCTS
    declined to find federal question jurisdiction not-
withstanding the presence of an underlying issue of patent
law.” NeuroRepair, 781 F.3d at 1348 (collecting cases).
   For the reasons above, we reverse the district court
based on this fourth element of Gunn as well.
                             II
    KidsEmbrace’s remaining arguments in favor of juris-
diction are unavailing. First, KidsEmbrace argues that
Counts I and II regarding breach of contract might also
confer jurisdiction. Second, KidsEmbrace argues its volun-
tarily dismissed state law counterclaims also create “aris-
ing under” jurisdiction. 9
    With regard to Counts I and II, KidsEmbrace tries to
fashion these state law claims


patents.” J.A. 141–
43. In KidsEmbrace’s view, these counterclaims raise sub-
stantial questions of embedded inventorship and validity
that meet all of Gunn’s requirements. We disagree for at
least two separate reasons.
    First, even if these claims did raise embedded patent
issues, they still fail to meet the third and fourth require-
ments of the Gunn test. In particular, nothing in the alle-
gations here shows that these claims will affect future suits
in the federal system. Each of KidsEmbrace’s counterclaim
pleadings are based on the warranties made between the
parties when entering the specific contractual relationship
set out in the Agreement. See, e.g., J.A. 141–43 ¶¶ 31, 37,
48. Based on the relief pled, KidsEmbrace’s counterclaims
only expressly seek damages for the royalties it paid under
INSPIRED DEVELOPMENT GROUP v. INSPIRED PRODUCTS      **6**, 37133; doi: 10.1038/srep37133 (2016).

**Publisher's note:** Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This work was supported by the National Natural Science Foundation of China (21471050) and Heilongjiang Province Natural Science Foundation of Key Projects (ZD201301).

**Author Contributions** G.H.Y. performed synthesis experiments, G.F.W. and H.G.F. designed the experiment. G.F.W. carried out photo-electrochemical evaluation and discussion. M.X.L, Mingqi Yu and C.G.T. carried out HRTEM and dynamic light scattering experiments. G.H.Y. and G.F.W. wrote the manuscript.

![XRD patterns of (**a**) Y~2~O~3~:Eu^3+^, (**b**) Y~2~O~3~/Y~2~O~2~S:Eu^3+^, and (**c**) Y~2~O~2~S:Eu^3+^.](srep37133-f1){#f1}

![(**a**--**c**) TEM and HRTEM images of Y~2~O~3~/Y~2~O~2~S:Eu^3+^ nanocomposites. (**d**) EDX spectrum of Y~2~O~3~/Y~2~O~2~S:Eu^3+^ nanocomposites.](srep37133-f2){#f2}

![Raman spectrum of Y~2~O~3~/Y~2~O~2~S:Eu^3+^ nanocomposites.](srep37133-f3){#f3}

![The XPS spectra of Y~2~O~3~/Y~2~O~2~S:Eu^3+^ nanocomposites.](srep37133-f4){#f4}

![The (**a**) excitation and (**b**) emission spectra of the Y~2~O~3~:Eu^3+^ nanocrystals.](srep37133-f5){#f5}

![Excitation spectra of Y~2~O~3~:Eu^3+^ and Y~2~O~3~/Y~2~O~2~S:Eu^3+^(YO/YOS-2) monitored at


subject to Marr's orders, and that he and the other operator would have left the job with the crane whenever instructed to do so by Marr. Moreover, Mooney testified that he was responsible for the crane whenever it was in motion. It follows that whether Mooney continued to be Marr's servant was a question of fact and that Marr's motion for a directed verdict was rightly denied.
Davis's motion for a directed verdict, on the other hand, should have been granted. There was no evidence that Davis exercised or could have exercised any control over the operation of the crane. Jenkins, Davis's agent, was present for the demonstration, but he gave no instructions to the operator and the oiler. It would have been sufficient if it had been shown== *-XX:MaxPermSize* ]] || [[ "${JAVA_OPTS}" == *-XX:MaxMetaspaceSize* ]] || [[ "${JAVA_OPTS}" == *-XX:ReservedCodeCacheSize* ]]; then
    echo ""
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    echo ""
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    # a ham-fisted attempt to move some memory settings in concert
    # so they need not be messed around with individually.
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configurable...
  checkJava "6"

  # Java 9 support
  copyRt

  #If we're in cygwin, we should use the windows config, and terminal hacks
  if [[ "$CYGWIN_FLAG" == "true" ]]; then
    stty -icanon min 1 -echo > /dev/null 2>&1
    addJava "-Djline.terminal=jline.UnixTerminal"
    addJava "-Dsbt.cygwin=true"
  fi

  # run sbt
  execRunner "$java_cmd" \
    $(get_mem_opts $sbt_mem) \
    $(get_gc_opts) \
    ${JAVA_OPTS} \
    ${SBT_OPTS:-$default_sbt_opts} \
    ${java_args[@]} \
    -jar "$sbt_jar" \
    "${sbt_commands[@]}" \
    "${residual_args[@]}"

  exit_code=$?

  # Clean up the terminal from cygwin hacks.
  if [[ "$CYGWIN_FLAG" == "true" ]]; then
    sttycompared to other wards.\[[@ref2]\] Even at our center, the incidence of candidemia is almost four times more common in ICUs as compared to the wards. In the ICU, the incidence is 14.95 per 1000 ICU admissions and the incidence in other wards is 4.09 per 1000 admissions. Montagna *et al*. in their study covering 18 ICUs in southern Italy reported an incidence of 16.5 cases per 1000 admissions.\[[@ref21]\] Molina *et al*. have reported 34.3 episodes of candidemia per 1000 ICU patients.\[[@ref22]\] An Indian neonatal ICU has reported an incidence of 77 cases per 1000 discharges in that hospital.\[[@ref18]\] Frausto *et al*. in an 18-month study conducted at seven surgical ICUs (SICUs) and six neonatal ICUs (NICUs) at six different hospitals of USA found an incidence of 9.8/1000 admissions


Team:'''
 F Walter Herrmann, Atenas
 F Leonardo Gutiérrez, Peñarol
 C Sam Clancy Jr., Gimnasia Indalo
 G Facundo Campazzo, Peñarol
 G Paolo Quinteros, Regatas Corrientes

References

Category:Liga Nacional de Básquet seasons

Argentinaof the Euclidean norm depending on the dimension $k$. Interestingly, this is the only choice of any continuous function $\xi$ such that the weighted $L^2$-distance $ C \int_{{{\mathbb R}}^k } \xi({\boldsymbol z}) |{\boldsymbol \varphi}_{{\boldsymbol X}}({\boldsymbol z}) - {\boldsymbol \varphi}_{{\boldsymbol Y}}({\boldsymbol z})|^2 \, d {\boldsymbol z}$ between the characteristic functions ${\boldsymbol \varphi}_{{\boldsymbol X}}$ and ${\boldsymbol \varphi}_{{\boldsymbol X}}$ is scale equivariant and rotational invariant.

The characterization by characteristic functions allows the energy distance to serve for powerful tests, see [@rizzo2016energy]. For instance [@szekely2013energy] show that the energy distance based test for multivariate normality has a high testing power, higher than all commonly used alternatives. Moreover, it can be utilized to test for non-parametric characteristics like symmetry or skewness. Another, very crucial feature is that the energy distance allows the construction of


Here, the energy distance reduction maintains perfectly the mean behavior in contrast to the Wasserstein distance. But, this comes at the cost of a worse capturing of the variance structure. For $m=5$ (Fig. \[fig\_ens\_energy\_m\_5\] and \[fig\_ens\_wasserstein\_m\_5\]) the picture is clear. The energy distance has a better approximation in all considered characteristics. Another fact that can be observed for $m=5$ is that in the last step from $t=4$ to $t=5$ the energy distance captures better the path dependency than the Wasserstein distance. In a binary tree the ratio of branches which go upwards and downwards is equally distributed. As $m=5$ is odd this can never be perfectly captured in an ensemble reduction. The energy distance reduction selects $3$ increasing and $2$ decreasing paths from $t=4$ to $t=5$. On thethe tendency to choose slightly more extreme trajectories. Consider e.g. $m=4$: The Wasserstein distance selected Aug’17 as representative summer trajectory. However, this Aug’17 trajectory has the lowest night load among all considered trajectories in the scenario set. The energy distance selects the Jul’19 path for the representative summer trajectory. This, has a slightly higher overall demand level, also during the night hours. For $m=3$, we observe a similar selection pattern. The energy distances chooses Dec’18 as representative winter trajectory whereas the Wasserstein distance goes for Jan’19. The latter has a more distinct evening peak.

### Forward reduction for demand profiles.

In this scenario reduction application we consider all daily electricity load profiles from 2019 as set of original trajectories. The $n=365$ trajectories are reduced to $m=2,\ldots,100$ scenarios. As this reduction


more distinct for larger $m$.

Discussion and Conclusion {#conclusion}
=========================

We illustrate that the energy distance is a suitable distance for ensemble and scenario reduction problems. It tend to provide better statistical/stochastic approximation properties than the popular Wasserstein distance which is vastly used in scenario reduction application. This holds particularly for path-dependency properties which are usually relevant in many applications, especially if you think about typical stochastic programs in energy systems like storage, maintenance and power trading optimization.

However, one drawback is that the reduction methods based on the energy distance is computationally more demanding than Wasserstein distance counterpart. This holds especially for the scenario reduction. Here, the Wasserstein distance has a simple explicit solution based on the redistribution rule which is linked to transportation problems, but the energy distance requires tothe critical density of the universe, we have $$\label{eq:Tmg}
T_{\rm mg} \propto \frac{{m_{\rm 1,v}}^{1/2}{r_{\rm p}}^2}{G^{1/2}m_{\rm 2} \ln \Lambda {r_{\rm 1,v}}^{1/2}}. \\$$ The Coulomb logarithm can be written as $\ln\Lambda \approx \ln\frac{b_{\rm max}}{b_{\rm min}}$, where $b_{\rm max}$ and $b_{\rm min}$ are the maximum and minimum impact parameters, respectively. When the satellite is initially outside the primary halo, and $b_{\rm max}$ approximates to the virial radius, we have $\ln\Lambda \approx \ln\frac{m_{\rm 1,v}}{m_{2,v}}$, if we take the virial velocity of the host halo as the initial velocity. Here $m_{1,v}$ and $m_{2,v}$ are the virial masses of the primary halo and the satellite halo, respectively, before the satellite enters the primary halo. In [@jiang08], they found that an alternative expression $\ln(1+\frac{m_{\rm 1,v}}{m_{2,v}})$ for the Coulomb logarithm performs better in explaining the time interval


$z=0.3$. Four samples of central galaxies are shown by different colored lines, with stellar masses of $30.0$ (black), $15.0$ (red), $7.5$ (green) and $4.0$ (blue), respectively, in unit of $10^{10}\msunhi$. The corresponding halo masses lie in the range from $10^{12.4}\msunhi$ to $10^{13.1}\msunhi$. Galaxy pairs are selected down to a stellar mass ratio of $1:32$, except for the lowest $m_{\rm 1,s}$ for which the lowest $M_{\rm 2,s}$ is not included, as galaxies at this mass consist of only $\sim 30$ particles, and are subject to resolution effect. Error bars are plotted assuming Poisson fluctuations for merger pairs. The number of central galaxies being considered is 326, 505, 940 and 1275, respectively, as the primary mass is lowered. Close pair counts increase as the satellite mass decreases. For the $m_{\rmunit volume $n_{1}N_{\rm p}(<r_{\rm
  p})$ is known, we can get the merger rate per unit volume by using Equation (\[eq:Tmg\_re\]) for the merger timescale. But for observations, it is the pair count in projection $N_{\rm p}^{proj}$ that is more easily accessible. If $N_{\rm p}^{proj}$ is used to measure the merger rate, i.e. $\Phi =n_{1}N_{\rm p}^{proj} (<r_{\rm p})/T_{\rm mg}^{proj}$, the projection effect must be taken into account and the merger timescale becomes $$\label{eq:Tmg_fin}
T_{\rm mg}^{proj}(<r_{\rm p})  = \frac{10^{-0.23}}{0.66} \frac {m_{\rm 1,v}}{m_{\rm 2,v}}
[m_{\rm 1,v}GH_{\rm 0}E(z)]^{-1/3} r_{\rm p}. \\$$

Equation (\[eq:Tmg\_fin\]) offers us a method of computing the timescale for mergers between primary galaxies with stellar mass $m_{\rm 1,s}$ and secondary galaxies with stellar mass $m_{\rm 2,s}$ within a projected radius of $r_{\rm p}$. Besides the radial extent $r_{\rm p}$


$8.2$ Gyr ($h=0.71$), corresponding to 1:1 mergers and 1:4 mergers respectively. The stellar mass is converted to halo mass using the relation between halo mass and central stellar mass established in [@mandelbaum06]. The timescale computed according to [@kitzbichler08] ($9.0$ Gyr) is only close to that for 1:4 mergers in our results. On the other hand, the merger timescales for the same galaxies but within projected $20\kpchi$ are between $0.31$ Gyr (1:1) and $1.6$ Gyr (1:4), by assuming $T_{\rm mg}^{proj}$ is proportional to the outmost radius. These all indicate that a single timescale is not sufficient to describe mergers with stellar mass ratios in the range from 1:1 to 1:4. We need to consider the dependence of the timescale on both virial masses of the two galaxies.

Conclusions
===========

Using a high-resolution                 提测版本:
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People’s
Republic of China, seeks review of a February 11, 2011,
decision of the BIA denying his motion to reopen his removal
proceedings. In re Chao Liang Lin, No. A077 553 708 (B.I.A.
Feb. 11, 2011). We assume the parties’ familiarity with the
underlying facts and procedural history in this case.

     We review the BIA’s denial of a motion to reopen for
abuse of discretion. See Ali v. Gonzales, 448 F.3d 515, 517
(2d Cir. 2006). When the BIA considers relevant evidence of
country conditions in evaluating a motion to reopen, we
review the BIA’s factual findings under the substantial
evidence standard. See Jian Hui Shao v. Mukasey, 546 F.3d
138, 169 (2d Cir. 2008). Generally, a motion to reopen must
be filed within 90 days after the date of entry of a final
order of removal.8 U.S.C. § 1229a(c)(7)(C). However, this
time limit does not apply if the motion is “based on changed
country conditions arising in the country of nationality or
the country to which removal has been ordered,” and if “such
evidence is material and was not available and would not
have been discovered or presented at the previous
proceeding.” 8 U.S.C. § 1229a(c)(7)(C)(ii). The alien
bears the burden of proving that country conditions have
changed. See 8 C.F.R. § 1003.2(c)(1).

     Here, Lin’s May 2010 motion to reopen was untimely in
relation to his September 2002 final order of removal, and
the BIA did not abuse its discretion in finding that Lin had
failed to establish changed country conditions. Contrary to
the argument in Lin’s brief, the BIA did, in fact, consider
the letters from a friend and relative that


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    let path = NSURL(fileURLWithPath: dir).URLByAppendingPathComponent(file)
do {
    let Direc = try NSString(contentsOfURL: path, encoding: NSUTF8StringEncoding)
    print(Direc)
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}

A:

Ok, based on the above info, I reckon there are two possible routes to take with this (pun intended)...
Option 1: Configure the 'back end' or the source of the information so that it delivers the instructions in two halves - direction and street - that way you can just discard the bit that you don't need when creating your required file. This would be simple and tidy, but may or may notselective deletion of ROQUIN in T cells does not lead to Tfh cell accumulation nor autoimmunity ([@bib5]). The latter is at least in part explained by the existence of the closely related family member ROQUIN2 (encoded by *Rc3h2*), which has overlapping functions with ROQUIN ([@bib67]; [@bib88]). The ROQUIN^M199R^ mutant protein has been proposed to act as a 'niche-filling' variant that has lost its RNA-regulating activity ([@bib67]) but can still localize to mRNA-regulating cytoplasmic granules to prevent the compensatory activity of ROQUIN2.

ROQUIN contains a conserved amino terminal RING finger with two conforming zinc-chelating sites ([@bib78]), despite an atypical aspartate as its eighth zinc ligand synonymous to RBX1 ([@bib35]). This suggests ROQUIN may function as an E3 ubiquitin ligase ([@bib15]) but, to date, no such enzymatic activity of the ROQUIN


This predicted ROQUIN^133-1130^ protein product specifically lacks the RING domain ([Figure 1---figure supplement 1f](#fig1s1){ref-type="fig"}). Mice homozygous for the *rin* allele were perinatally lethal ([Figure 1---figure supplement 1g--i](#fig1s1){ref-type="fig"}), precluding T cell studies in intact animals. In contrast, *Tringless* mice were viable and showed no severe variations in thymic development and output of CD4 single positive T cells ([Figure 1---figure supplement 2a--e](#fig1s2){ref-type="fig"}). There were also no major changes in Th1 cell differentiation in *Tringless* mice infected with LCMV ([Figure 1a](#fig1){ref-type="fig"}), which predominantly yields LY6C^high^ Th1 and LY6C^low^ Tfh virus-specific effector cells ([@bib26]; [@bib56]). In *Tringless* animals immunized with SRBCs, the formation of Th1, Th2, Th17, and regulatory T cells also remained largely unperturbed ([Figure 1---figure supplement 2f, g](#fig1s2){ref-type="fig"}). This was mirrored *in vitro* with *Tringless* CD4^+^ naive T cells activatedunder Th1, Th2, Th17, or induced Treg (iTreg) polarizing conditions ([Figure 1---figure supplement 2h](#fig1s2){ref-type="fig"}) displaying maximal expression of intracellular TBET, GATA3, RORγT, and FOXP3 comparable to floxed wild-type T cell cultures ([Figure 1---figure supplement 2i](#fig1s2){ref-type="fig"}). Surprisingly in *Tringless* mice, there was an overall defective Tfh cell primary response to LCMV infection ([Figure 1b--d](#fig1){ref-type="fig"}) and to SBRC immunization ([Figure 1---figure supplement 3a](#fig1s3){ref-type="fig"}). ROQUIN RING-deficient T cells were also inefficient in supporting GC formation ([Figure 1e, f](#fig1){ref-type="fig"} and [Figure 1---figure supplement 3b](#fig1s3){ref-type="fig"}), which was associated with reduced IL-21 production ([Figure 2a](#fig2){ref-type="fig"}), a Tfh signature cytokine vital in supporting GC reactions ([@bib52]).10.7554/eLife.08698.003Figure 1.ROQUIN RING deletion in T cells preferentially controls Tfh cell formation.(**a-f**) Flow cytometric examination of mice d10 post-LCMV infection. (**a**) Proportion of LY6C^+^ total Th1 cells from CD4^+^CD44^high^ T


vitro* and in a cell-based ubiquitin assay. By Coomassie staining PAGE-separated peptides of *in vitro* ubiquitination reactions, we detected a single protein band having higher molecular weight relative to ROQUIN peptide that formed in the presence of wild-type ROQUIN^1-484^ and ubiquitin ([Figure 4e](#fig4){ref-type="fig"}). This slowly migrating band, consistent with monoubiquitin attachment, formed at severely delayed times in the absence of the RING zinc finger. A complete absence of this higher molecular weight ROQUIN peptide modification was observed with *in vitro* reactions lacking ubiquitin protein. We also performed ubiquitination assays in transfected HEK293T cells and detected ubiquitin-conjugated ROQUIN by immunoprecipitation when full-length ROQUIN was over-expressed but not with expression of the ROQUIN^133-1130^ variant recapitulating the specific RING deletion borne by *Tringless* T cells ([Figure 4f](#fig4){ref-type="fig"}). Together, our data showRING domain did not abrogate ROQUIN^133-1130^-AMPKα1 colocalization; the two proteins were detected in small aggregates most likely outside of stress granules ([Figure 5d](#fig5){ref-type="fig"}). This was consistent with RING deficient ROQUIN^133-1130^ protein still capable of directly binding AMPKα1 ([Figure 5e](#fig5){ref-type="fig"}). Together these findings indicate that ROQUIN RING signaling does not play a role in AMPK recruitment to ROQUIN but rather directs negative regulation of AMPKα1 through sequestration into stress granules following ROQUIN--AMPKα1 complex formation.10.7554/eLife.08698.011Figure 5.ROQUIN RING activity controls its localization to stress granules.(**a**) Colocalization of over-expressed full length V5-tagged ROQUIN or ROQUIN^133-1130^ with endogenous eIF3 in HEK293T cells stressed with 1 mM arsenite (AS) for 1 hr with or without 2 mM AICAR. Scale bar, 50 μm. (**b**) Crystal structure of ROQUIN peptide showing amino terminal residues 6 to


counts of eIF3^+^ granules per cell (**c**), and size of individual eIF3^+^ granules in freshly arsenite-stressed primary MEFs based on area (**d**) and maximum feret (**e). (f**) Proportion of recovering primary MEFs exhibiting cytoplasmic eIF3^+^ stress granules (SG) after arsenite-mediated stress (n \>30 per time point, with each n replicate representing a single field of view displaying 1--7 adherent cells). Columns, mean; error bars, s.d. (**g**) Representative micrographs displaying recovered primary MEFs at 3 hr post-arsenite stress. Scale bar, 50 μm. Statistics were calculated by Student's t-test, n.s., not significant; \**p*\<0.05; \*\*\**p*\<0.0005. Data are representative of three independent double blind experiments. (**h**) Proportion of primary MEFs with eIF3^+^ stress granules after 1 hr of 1 mM arsenite treatment comparing wild-type and *sanroque* MEFs recovering in complete DMEM media. Datademonstrating the ability of ROQUIN and AMPKα1 to bind each other and colocalize within stress granules together with previous observations of stress granule exclusion of RING-deficient ROQUIN ([@bib67]), we propose a model whereby ROQUIN may be repressing AMPK activity via ubiquitin-dependent sequestration of the AMPKα1 subunit within stress granules and thereby promoting repression of AMPK kinase activity. This stress granule-associated regulation of AMPK may not be exclusive to ROQUIN but could involve other binding partners such as G3BP1, which has been shown to localize with AMPKα2 in stress granules ([@bib54]). Interestingly, a direct interaction has also been observed between AMPKα and G3BP1 ([@bib4]), an integral component of stress granules that associates with ROQUIN ([@bib24]). Analogous to the T cell anergy-regulating RING-type E3 ubiquitin ligases GRAIL and CBL-B that


remove the *neo* cassette. Mice harboring the floxed *Rc3h1* allele (*Rc3h1^lox/+^*) were then crossed to *Rosa26:Cre* knock-in mice for one generation. Removal of Cre expression was then achieved by a C57BL/6 backcross yielding a germline deletion of *Rc3h1* exon 2. This strain was named *ringless (rin* allele). A conditional ROQUIN RING-deficient strain (called *Tringless*) was also generated by crossing *Rc3h1^lox/lox^*mice to *Lck:*Cre breeders to remove *Rc3h1* exon 2 specifically in T lymphocytes (*Trin* allele). Upon Cre-mediated excision of *Rc3h1* exon 2, rescue of in-frame protein synthesis at Met^133^ is expected to produce an E3 ligase defective ROQUIN mutant. *Rosa26:Cre* and *Lck:Cre* mice were maintained on a C57BL/6 background with one copy of the Cre transgene and provided by Ozgene, Australia. ENU-derived *chino* mutants were previously characterized ([@bib10]). To generate mixed bone marrow chimericauthors here investigate the effect of specific depletion of the RING domain of ROQUIN and unexpectedly find that this domain has a positive role in Tfh formation in contrast to the overall negative role of ROQUIN. They describe that this loss of Tfh formation and function is due to loss of ROQUIN RING dependent antagonism of AMPK which in turn causes loss of mTOR function that, through largely unknown mechanisms, inhibits Tfh formation.

Major comments:

1\) In [Figure 7](#fig7){ref-type="fig"}, Foxp3 MFI rose in the *chino* mutants. As the authors of this paper have previously demonstrated CD4^+^PD1^+^CXCR5^+^ cells are made up of a mixture of Foxp3- Tfh and FOXP3^+^ Tfr cells. A rise in the MFI of Foxp3 fails to determine if this is Foxp3 expression being induced by Tfh or,


the Tfh program, CXCR5 and *Bcl6*. It raises the question of how the ROQUIN-AMPK-mTOR axis controls the expression of CXCR5 and *Bcl6* and what is a target of this pathway. It is recommended that the authors show transcriptome data of TFH cells in the ROQUIN RING loss mice and the hypomorphic mutant mice of the *Frap1* gene and compare.

5\) The FACS profile indicating GC-B in the hypomorphic mutant mice of the *Frap1* gene is clearly different from that in the ROQUIN RING loss mice ([Figure 1d](#fig1){ref-type="fig"}). We hope you can show the impact on humoral responses, because TFH and GC-B cell development is not convincing enough to prove the impact in humoral responses. It is recommended they show the antibody responses in the response to LCMV.

6\) The findingnot understand the role of Trin in Tfr. In much the same way that looking at total CD4 cells would not have revealed the effects on Tfh looking at total Tregs will not reveal any Tfr specific effects. Given the known role of mTOR inhibitors such as rapamycin in enhancing Treg numbers and the data in [Figure 7e](#fig7){ref-type="fig"}, it is plausible that the Tfh/Tfr ratio may be altered. Addressing this point will both strengthen the conclusions on Tfh (by confirming what percentage of them are actually Tfh) and add impact by widening the results to include or exclude an effect on Tfr. This issue can be quickly and simply addressed by including some indication of the percentage of Foxp3 expression within the PD1^+^CXCR5^+^ population Tfh in [Figures 1](#fig1){ref-type="fig"}


Summer Holidays Week 1 23/07 - 27/07

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“These official BWFC Courses are not only great for all the youngsters that take part, as they learn about teamwork, haveliberties groups that have suffered a number of setbacks to their agendas as the federal government has sought new powers to hunt down terrorist suspects.

Michelle Richardson, legislative counsel in the American Civil Liberties Union’s Washington office, said Wyden has stepped into a leadership void on balancing civil liberties with national security needs left by the departure of former Sen. Russ Feingold, D-Wis.

Wyden’s approach, Richardson said, has been to try to enlist others in his cause. His staff has offered classified briefings to senators at times, and she said he has “serious intelligence chops” that make his peers take him seriously.

“There are probably a lot of people who you could say are a great lone voice or always vote the right way,” she said. “It’s another thing altogether if


required to follow through. (After
accepting, you have the choice to either pickup and confirm receipt or opt out
by canceling, in any combination.)

As a driver, doubles are overwhelmingly not worth it in my city. For example,
if I get paged for an order it may be for delivery from restaurant A to
dropoff C. At any time before I arrive do the pickup, I may get paged to pick
up an additional order. There only a narrow set of circumstances where it is
worth it to me, the driver, to accept a double. Here's a list of things that
would make a double unfavorable for a driver:

\- The dropoff for the additional order may be at some point B that more or
less lies somewhere along your route from A to C. Uber will routeconsciously intended to counter the legal and law-enforcement careers of his forebears, he (Edmund...

Stephanie Marcellus is an assistant professor at Wayne State College, where she teaches creative writing and literature courses. She recently received her doctoral degree in British literature from the University of South Dakota and also holds an MFA in creative writing from Colorado State University. ...

Liz Daehnke is an editor for the WSC Press. She earned both her bachelor's and master's degrees from Wayne State College. For the last several years she has also been an assistant to the publisher at Logan House Press.

Tyisha Wrice graduated in 2012 with a Bachelor's degree in Graphic Design, English Writing and Editing & Publishing. In 2014, she decided to pursue a Master of Science in Education while working


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A:

Remove the color=black option, and apply a style to each node via every node/.style=:

Code:
\documentclass[a3paper]{article}
\usepackage{calc,graphicx,eso-pic,tikz,}

\tikzset{My Node Style/.style={draw=pink, fill=pink, fill opacity=0.50, text opacity=1}}

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    \node [transform shape] (Label)- 3 Things to Do, 3 Points to Avoid in Pinehurst, TX

Execute it is been observed when compared with many companies may also be hiring they then. So the very next time when you see massive heap associated with trash immediately after party than just relaxed because you know that men and women from waste provider take presctiption their means!!!!!
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Keeping your site safe and clean can be done with a dumpster. A variety of