include the donor's blood, the environment (including the air, and the equipment in the environment), the donor's skin plug, and the phlebotomist.
Since some blood components (particularly platelets) are typically stored at ambient temperatures (e.g., about 22–26° C.), the problem of contamination may be magnified, as most bacteria reproduce more rapidly at ambient temperatures than at, for example, about 2–8° C.
Contaminated blood products, especially bacterially contaminated blood products, pose a potential health risk to those who come into contact with, or receive, these products. For example, the administration of transfusion products with bacterial contamination can have adverse affects on the recipient, and the administration of platelets with massive levels of bacterial contamination is implicated in about 150 cases of severe morbidity or death each year in the U.S.
Typical bacterialboundary of $B_{\delta}^{x^{\ast}}$, we have $\zeta\rightarrow\infty$, and $$S^{x^{\ast}}(x)=S^{\infty}(x)\begin{pmatrix} 1 & O\left(e^{2Z_t}\zeta^{-1}\right)  \\
0 & 1
\end{pmatrix}$$ but from the expression of $Z_t$ (\[eq:Ztau1\]) and the property of the equilibrium measure (\[eq:hineq\]), we see that $Z_t<0$ and hence $e^{2Z_t}$ is bounded. Hence we have $$S^{x^{\ast}}(x)=S^{\infty}(x)\left(I+O\left(n^{-\frac{1}{2\nu}}\right)\right)=
\left(I+O\left(n^{-\frac{1}{2\nu}}\right)\right)S^{\infty}(x)$$ This completes the proof of the proposition.

Last transformation of the Riemann-Hilbert problem
--------------------------------------------------

Let us now define $R(x)$ to be the following function. $$\label{eq:Rx}
\begin{split}
R(x)=\left\{
       \begin{array}{ll}
         S(x)\left(S^{r_i}(x)\right)^{-1}, & \hbox{$x$ inside $B_{\delta}^{r_i}$;} \\
         S(x)\left(S^{\infty}(x)\right)^{-1}, & \hbox{$x$ outside of $B_{\delta}^{r_i}$.}
       \end{array}
     \right.
\end{split}$$ where $r_1=-2$, $r_2=2$, $r_3=x^{\ast}$ and $S^{\pm 2}(x)$ are the local parametrices near the edge points $\alpha_t$


The chimney might not be a part of your home you consider very often, but keeping it in good working order is a critical part of ensuring a safe and healthy home.

See More

Why would Kris Kringle choose to squeeze his considerable girth through one of the narrowest and most soot-covered passageways in the home? The answer: Who the heck knows? One thing is certain, however. For those homeowners with a fireplace, safe and hassle-free evenings spent around the hearth depend not only on a proper understanding of how a chimney works, but also on a commitment to maintaining the chimney. Santa’s entrance comes in two styles:

Built of either brick or stone, traditional masonry chimneys include a firebox (where the wood burns) in addition to a flue, which iswith competition. In 2010, Kinzel announced that he would retire. On June 20, 2011, it was announced that Matt Ouimet would take over as CEO of Cedar Fair, effective immediately. Dick Kinzel officially retired on January 2, 2012, when his contract was up.

Life after Cedar Fair
In an article in the Toledo Blade, Kinzel stated that life would be very different once he retired. He hadn't had a summer off since joining the company and so planned to take many vacations. Though he'd been asked to work on a few projects, he wanted to take some time off. On May 9, 2013, Kinzel announced that he would be stepping down from the board of directors of Cedar Fair. He also said he plans to stay in Sandusky but has


Joe Bartolo told me this afternoon the signing was postponed after he claims death threats were made against him, his wife Jamie — the owners of JJ Cards N Toys — and their family for organizing Vick’s appearance in October at a local Buffalo Wild Wings restaurant.

Those making the threats were upset the Bartolos would bring Vick to the area. Vick served 18 months in federal prison for running an illegal dogfighting ring. Bartolo told me thousands of threats were coming in from all the country. He even had to shut down the store’s Facebook page.

This is getting ridiculous, you don’t have to like Mike Vick, but threatening to kill anyone’s family because he is signing some autographs, make your a sicker person than Vick ever was.now, Vermont environmentalists have warned about the possibility of the flow of the lines being reversed and Canadian tar sands oil being shipped south and west through them from Alberta to Maine. For two years, 350 Vermont has attempted to show opposition by persuading towns to adopt resolutions at Town Meeting.

Although their efforts were a bit more organized this year, they still seem to be inept at best. One of the towns that would be most severely affected by any oil spill is Barton, yet that town will not be voting this year on a tar sands resolution.

Featured

State Police fire investigators have concluded that the fire that totaled all four of the Albany Fire Department’s vehicles was deliberately set. Pictured is smoke blackened engine number one, where the


fire started. Photo by Tena Starr

by Tena Starr

ALBANY — An Albany firefighter, who allegedly told police he has a problem with fire and needs help, has been accused of trying to burn down his own department.

Elmer Joerg, 45, of Holland pled innocent last week in the Criminal Division of Orleans Superior Court to a count of second degree arson and another of reckless endangerment. He was held on $250,000 bail.

The fire, which occurred at about 1 a.m. on August 11, ruined all of the Albany department’s vehicles and much of their equipment. The department is back in business, though, due to the generosity of other communities that have donated everything from helmets to trucks.

Police affidavits say that a trail of Natural Light beer cans, as well as gamecardboard with that, and ultimately lit the cab of fire engine number one, he allegedly told police.

Mr. Joerg said he then fled the scene and later returned as an Albany firefighter.

Monica Grondin told State Police Fire Investigator Detective Sergeant David Sutton she saw someone inside the firehouse about 1:15 that morning. After leaving the building, he started his ATV and drove along the shoulder of Main Street past her home with the headlights off, she said.

In the course of the first interview with investigators, Mr. Joerg allegedly told them “he set the fire because he had a problem with fire and thinks about setting fires often, and has urges to set fires that he is usually able to control.

“He also advised that he is a danger because he


a mile away, the long, sinuous ridgeline known as Lowell Mountain.

Now that view is dominated by the 21 towers of the Lowell wind project, their blades reaching 460 feet high. And the house is for sale at a discounted price.

“What I came here for is gone,” said Ms. Goodrich, a Wolcott native who worked for IBM in Chittenden County and then spent ten years with her husband in a landscaping business.

“This was going to be where I spent the rest of my life — quiet, peaceful, relaxed,” Ms. Goodrich continued. “But I can’t stay here.”

One of the features their home has lost is the quiet, the couple says.

“Sometimes they’re really loud,” Ms. Goodrich said. In one hot spell, with the bedroom windows open and two fans running, sherecalls, “I could hear them over everything. It was some kind of roar.”

He suspects that the turbines often exceed the limits imposed when the state Public Service Board (PSB) gave the project its certificate of public good. Mr. Goodrich sounds unconvinced by Green Mountain Power’s claim that its turbines have remained within those limits — 45 decibels outside, 35 inside — 99 percent of the time since they began to spin in late 2012.

Ms. Goodrich thinks the noise limits miss the point.

“I don’t doubt that most of the time they’re in compliance,” she said Monday. “But to me, those guidelines are too much for people to handle, hour after hour after hour.”

The couple is not sure whether the turbines are affecting their health. Mr. Goodrich recently experienced blade


his attackers said he was in “MAGA country.” MAGA is shorthand for Trump’s campaign slogan, “Make America Great Again.”

Chicago police said they were told two people approached Smollett at 2 a.m. and yelled homophobic and racial slurs at the actor. According to police, Smollett said the attackers hit him, poured an unknown chemical substance on him, and put a rope around his neck. Earlier in the month, a letter threatening Smollett that included a homophobic epithet and white powder, which turned out not to be dangerous, was mailed to the set where Empire is filmed, police said. The FBI is investigating the letter as Chicago police investigate the incident as a possible hate crime, according to the Chicago Tribune.

Trump has yet to comment on Smollett’s account. Similarly, nonereadSwiftPackages(path: packageResolvedPath)
    } else {
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        .deletingPathExtension()
        .appendingPathExtension("xcworkspace")
        .appendingPathComponent("xcshareddata")
        .appendingPathComponent("swiftpm")
        .appendingPathComponent("Package.resolved")
        return readSwiftPackages(path: packageResolvedPath)
    }
}

private func readPodsAcknowledgements(path: URL) -> [String] {
    if path.lastPathComponent != Consts.podsDirectoryName {
        fatalError("Invalid Pods name: \(path.lastPathComponent)")
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        path.appendingPathComponent("Target Support Files"),
        path.appendingPathComponent("_Prebuild").appendingPathComponent("Target Support


first time trying Afghan food and we had a great experience. Inexpensive, delicious and simple. Very laid back and feels like a family-run establishment. Everything we had was flavorful, especially enjoyed the eggplant with yogurt."

2. Saffron Kabob House

Photo: Emzy L./Yelp

Next up is Saffron Kabob House, situated at 5711 Hillcroft St., Suite B2, in Sharpstown. With 4.5 stars out of 94 reviews on Yelp, the Middle Eastern and Afghan spot, offering kebabs and more, has proven to be a local favorite.

The menu includes dishes like the Bolani (an Afghan calzone stuffed with chopped leeks, potatoes and cilantro, seared on the grill with seasonings), the Chapli Kebab (grilled sirloin mixed with scallions, cilantro and seasonings) and the Dahl Soup (lentil soup seasoned with garlic and peppers and served with freshChristian Kabalists, more or less, in the dead letter of the allegory of the fall of man.

In referencing of the Hellenic origin of the word, it might be understood to emerge from 'αυγο', meaning 'egg', or 'αυγή', meaning 'dawn', combined of 'είδηση', indicative of 'news' or 'a message', and thus the connection in Aleister Crowley's mind between the 'egg message' and 'the Knowledge & Conversation of the Holy Guardian Angel' or 'higher & original (egg) genius' associated of one's human being. Combined of 'είδωλο', an 'idol' or 'reflection', one might see in it Plato's 'luminous being', a 'reflection of the dawn'. Such a direct etymology is, however, admittedly speculative and subject to revision or reconfirmation by another.

References

External links
https://web.archive.org/web/20060118085654/http://www.prometheustrust.co.uk/TTS_Catalogue/2_-_Porphyry/2_-_porphyry.html
https://web.archive.org/web/20051123012154/http://blavatsky.net/topics/near-death-experience/siemons.htm

Category:Theosophical philosophical concepts


---
abstract: 'Two elementary formulae for Mertens function $M(n)$ are obtained. With these formulae, $M(n)$ can be calculated directly and simply, which can be easily implemented by computer. $M (1) \sim M (2 \times 10^7) $ are calculated one by one. Based on these $2\times 10^7$ samples, some of the complicated properties for Mertens function $M(n)$, its 16479 zeros, the 10043 local maximum/minimum between two neighbor zeros, and the relation with the cumulative sum of the squarefree integers, are understood numerically and empirically.'
address: 'College of Earth Sciences, University of Chinese Academy of Sciences, Beijing, PRC, 100049'
author:
- Rong Qiang Wei
title: Two elementary formulae and some complicated properties for Mertens function
---

[Keywords:]{}

[Mertens function Elementary formula Zeros Local maximum/minimum squarefree integers]{}

Introduction
============

The Mertens function $M(n)$ is important in number theory, especially the calculation of(recursive) formulae for Mertens function $M(n)$ in the mathematical literature by which the practical algorithms for the $M(n)$ can be obtained (eg., Neubauer, 1963; Dress, 1993; Benito and Varona 2008; and the references therein). For example, Benito and Varona (2008) present a two-parametric family of recursive formula as follows,

$$\label{eq7_add}
\begin{array}{*{20}{l}}
{2M(n) + 3}&{ = \sum\limits_{k = 1}^{\left\lfloor {\frac{n}{{r + 1}}} \right\rfloor } {g(n,k)\mu (k)} }\\
{}&{ + \sum\limits_{b = 0}^s {[M(\frac{n}{{3 + 6b}}) - 2M(\frac{n}{{5 + 6b}}) + 3M(\frac{n}{{6 + 6b}}) - 2M(\frac{n}{{7 + 6b}})]} }\\
{}&{ + \sum\limits_{a = 6s + 9}^r {h(a)[} M(\frac{n}{a}) - M(\frac{n}{{a + 1}})]}
\end{array}$$

where $n$, $r$, and $s$ are three integers such that $s\ge 0$ and $6s+9\le r \le n-1$. $g(n,k)=3\lfloor\frac{n}{3k}\rfloor -2\lfloor\frac{n}{2k}-\frac{1}{2}\rfloor$. $h(a)=g(n,k)$ for $\frac{n}{a+1}<k\le\frac{n}{a}$.

Here we introduce two new elementary formulae to calculate the $M(n)$ which are


firstly when $k$ or $n$ changes. It will take a lot of calculation time, especially when $n$ is large. It took about 78326s to get $\mu(5500000)$. It can be also found that the relation here is not efficient for the isolated $M(n)$.

In this paper, we only calculate the values of $M(n)$ from $M(1)$ to M($2 \times 10^7)$ because of the limitation of our desktop computer and computing time. To obtain more numerical results of $M(n)$ with large $n$, both the faster and/or optimization algorithm for the relation (\[eq9\]) or (\[eq9\_add\]) here, or other professional and efficient algorithms, are required.

Upper bound of $M(n)$ sequence
------------------------------

In Wei (2016), the upper bound of $M(n)$ sequence is discussed based on the assumption that $\mu (n)$ is an independent random sequence, because of theup as much of the perimeter as necessary. More Border Force search and dog teams will also be sent in."

He said: "We rule nothing out in dealing with this very serious problem."

The UK is offering to replace green mesh fencing at the Eurotunnel entrance perimeter in Coquelles, near Calais, with solid fencing of the type normally seen at Nato summits.

Calais migrant crisis Impact on Kent council social services 629 the number of unaccompanied children seeking asylum that require care from Kent county council 220 the equivalent number in March 2014

£5.5m funding shortfall according to the council

Meanwhile, Operation Stack - in which lorries queue on the M20 when Channel crossings are disrupted - is expected to continue into the weekend.

Ministry of Defence sources suggested land could be released for


it.
However, if the goal was originally to actually capture the opponent's king, this raises another interesting question:
What happens if the goal is to capture the king, moving into check is allowed, and you still have no legal move?
For example:
   [fen "3k4/8/8/8/1p1p4/pPpPp3/PRP1P3/NKN5 w - - 0 1"]

If it is White to move, this position is stalemate under modern rules, but if there's no stalemate, and Black has to capture the white king to end the game, does White just skip a move, and then 1…axb2 2.Kxb2, cxb2#, or would they just look at material, position, whatever, and work out who should win, agree to a draw, or just end the game with no result and replay it or something?

UC Berkeley alumna, this gracious and immensely talented architect has intrigued and inspired me in immeasurable ways. Her legacy is relevant today for her vernacular approach to sustainable architecture and fearless endeavors to advance in a profession that reluctantly opened its doors to women in the early 20th century.
-more-

Until recently, you could have lived your entire life in the United States and never have bumped into any Jewish Orthodox Hasidim, who live in scattered communities, mostly in the New York’s borough of Brooklyn.
-more-

Most graffiti are ephemeral. All graffiti are anarchic and adventitious. They can crop up anywhere -- not only on walls, but on dumpsters, bridges, curbs and sidewalks. Some graffiti only survives a day or two but, once in a while, someone leaves behind a graffito that


Peter visited the Bay Area when his older daughter was a Science Fair contestant here, and we got to know the bride, Laura, his younger daughter, when she and a friend visited Berkeley one summer while they were students.

The wedding became the catalyst for a family reunion of sorts. Her father’s four surviving siblings (plus a sizable representation of spouses, offspring and grandkids) showed up in Tallahassee. The older ones I remembered fondly from childhood, before our families moved away from St. Louis, and I enjoyed getting to know the younger ones and their descendants better. I was pleased to discover that they’re very nice people, all of them, good politics, sense of humor, smart, the whole nine yards of how you might hope distant relatives would turnIntroduction {#sec1}
============

According to the World Health Organization (WHO), pneumonia is the most common infectious disease worldwide. It is associated with very high morbidity and mortality, especially among patients with a compromised immune system or small children.^[@ref1]^ In 2015, pneumonia killed 92 0136 children under the age of five, accounting for 16% of all deaths of children under five years.^[@ref2]^ Pneumonia can be caused by bacteria, viruses, or fungi.^[@ref3]^ Most often, bacterial pneumonia is induced by an infection with *Streptococcus pneumoniae*.^[@ref4]^ Currently, the gold standard for diagnosing this disease is the microbiological cultivation of the pathogens along with an X-ray examination of the lung and a blood cell count.^[@ref5],[@ref6]^ Unfortunately, this approach is very time consuming and not all pathogens can be successfully cultivated. Accordingly, for therapy, a broad-spectrum antibiotic


detection of *S. pneumoniae*.^[@ref19]^

While it is encouraging that various promising attempts for a fast diagnosis of bacterial pneumonia already have been made, some challenges still remain. For instance, many approaches only encompass the amplification and detection steps, omitting the sample preprocessing which is necessary for the application of real samples. Others only address single species. The aim of the present study is to cover the entire process chain, starting with an efficient isolation and enrichment of the bacteria from patients' sputum samples up to the specific detection of eight pneumonia-relevant pathogens in parallel ([Figure [1](#fig1){ref-type="fig"}](#fig1){ref-type="fig"}). With regard to the potential application in point-of-care testing, we made special efforts to incorporate cost-efficient materials and to keep the assay as simple and convenient as possible. For sample preparation, we employedEGB and PEI-modified particles (PEI).](ao-2019-00904t_0002){#fig2}

Detection of Patient Isolates {#sec2.2}
-----------------------------

In order to investigate the applicability of the abovementioned assay, the optimized protocol was further tested for several strains of *S. pneumoniae*, *S. aureus*, and *H. influenzae* isolated from patients of the University Hospital Jena. For this purpose, artificial sputum was spiked with ten different strains to a final concentration of approximately 10^5^ cfu/mL. Subsequently, the complete protocol starting from the isolation of the pathogens with EGB was conducted. The results of the gray value analysis from the polymer chips after performing the hybridization assay are depicted in [Figure [3](#fig3){ref-type="fig"}](#fig3){ref-type="fig"}. Because no unspecific signals at the noncomplementary probe positions were detected, we only included the values of the correct species-specific probes for better comprehensibility. The detailed evaluation of each chip


can be found in the [Supporting Information](http://pubs.acs.org/doi/suppl/10.1021/acsomega.9b00904/suppl_file/ao9b00904_si_001.pdf) (see Figure S4). Overall, the results are in good agreement with the previously investigated strains. We were able to unambiguously detect all of the ten patient strains. For the two isolates of *H. influenzae*, the intensities of the gray values were even more pronounced than those of the ATCC 9007 strain. The same trend was observed for the three *S. pneumoniae* isolates, the gray values of which all exceeded 80%, while the type strain DSM 20566 typically yielded intensities of approximately 55%. For the five isolates of *S. aureus*, we obtained signal intensities between 40 and 80%, while the type strain DSM 20231 displayed a mean intensity of 55% in comparable experiments. These results indicate that the established protocol is capableand cost-efficient materials, wherever possible, that is, EGB, which are a byproduct from glass recycling. Our sample preparation strategy relies on amine-functionalized particles, which are capable of isolating a broad range of different Gram-negative and Gram-positive species, as demonstrated in this study. The species-specific identification was achieved with a hybridization assay on low-cost polymer chips. An additional advantage of these chips is the simple functionalization with capture probes, without the need of any additional surface modification. The detection method based on enzyme-catalyzed silver deposition is not only robust, but also entails great potential for an automated readout and analysis, that is via smartphone. We successfully detected eight species in an artificial sputum matrix and could also show that the previously optimized parameters work well for different patient strains.


*K. pneumoniae*, *M. catarrhalis*, *P. aeruginosa*, *S. aureus*, and *S. pneumoniae*. The strains were either purchased from the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures (DSMZ, Brunswick, Germany) or isolates from patients' samples provided by the Jena University Hospital (UKJ, Jena, Germany). All species, except from *H. influenzae* which was raised on chocolate agar with Vitox (Oxoid Deutschland GmbH), were cultivated on Columbia sheep blood agar (Oxoid Deutschland GmbH). The spiking of the sputum samples was carried out with cells from the exponential growth phase. To that end, 5 mL of the liquid growth medium (further information, see [Table [1](#tbl1){ref-type="other"}](#tbl1){ref-type="other"}) was inoculated with a small amount biomass from an agar plate and incubated overnight at the appropriate temperature. On the next day, 2--3 mL of thefinally with a polyetheramine (JEFFAMINET403, Huntsman Corp., Bergkamen, Germany), each as a solution in toluene. The polyethylene particles (Ticona GUR 2122) had a size distribution between 100 and 200 μm and were functionalized with Lupasol WF (BASF, Ludwigshafen, Germany) and succinic anhydride as previously described.^[@ref20]^ Scanning electron microscopy (SEM) images of the particles can be found in the [Supporting Information](http://pubs.acs.org/doi/suppl/10.1021/acsomega.9b00904/suppl_file/ao9b00904_si_001.pdf) (see Figure S6).

Primer and Probe Design {#sec4.4}
-----------------------

The following genes were selected as species marker for the herein described assay: *basC* (*A. baumannii*), *gad* (*E. coli*), *fucK* (*H. influenzae*), *khe* (*K. pneumoniae*), *copB* (*M. catarrhalis*), *ecfX* (*P. aeruginosa*), *nuc* (*S. aureus*), and *lytA* (*S. pneumoniae*) ([Table [2](#tbl2){ref-type="other"}](#tbl2){ref-type="other"}).

###### Primers and Capture Probes

  species            primers and probes


  *S. aureus*        S. au. for[a](#t2fn1){ref-type="table-fn"}    AGCATCCTAAAAAAGGTGTAGAGA         57.6                                 87                     nuc           from Pichon et al.^[@ref27]^ and McDonald et al.^[@ref28]^
               primer ratio between biotinylated and nonbiotinylated primers was 0.2:0.05 μM as determined experimentally (data not shown). A single reaction mix contained 1 μL cell lysate, 1× PCR buffer, 2.5 mM MgCl~2~, 0.4 mM dNTPs, 0.2 μM of each primer, and 0.1 U/μL Taq Polymerase (innuTaq DNA Polymerase Kit, Analytik Jena AG, Germany) in a final volume of 30 μL. All PCR reactions were carried out with the thermocycler FlexCycler (Analytik Jena AG, Jena, Germany). The PCR was performed with the following cycle profile: initial denaturation at 95 °C for 300 s, 45 cycles of denaturation at 94 °C for 30 s, and annealing/elongation at 58 °C for 30 s.

Successful DNA amplification was verified on a 2% (w/v) agarose gel. For visualization, the DNA was stained with GelRed (Biotium,


Felsbachstraße 9, 07745 Jena, Germany.

The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. S.P. and L.L. contributed equally to this work.

The authors declare no competing financial interest.

Funding of the research projects "Intersept" (13N13852), "EXASENS" (13N13856) and "InfectoGnostics" (13GW0096F) by the Federal Ministry of Education and Research, Germany is gratefully acknowledged. Furthermore we would like to thank Prof. Dr. Bettina Löffler from the Institute of Medical Microbiology (University Hospital Jena) for kindly providing all investigated bacterial strains and Prof. Dr. Marie von Lilienfeld-Toal from the Department of Hematology and Medical Oncology of University Hospital Jena for kindly providing the sputum samples. We also want to thank Dr. Jan Dellith from the Leibniz IPHT, Jena for acquiring theBemiparin in oncology.
An association between cancer and thrombosis has been recognized since 1865. It is considered to be a two-way association; cancer is associated with an increased risk of venous thromboembolism (VTE), whereas activation of the coagulation cascade enhances the proliferation, angiogenesis potential and metastasis of tumour cells. A sizeable proportion of VTE events in cancer patients undergoing major surgery occur after discharge from hospital, suggesting that extended thromboprophylaxis beyond the normal 7-10 days is warranted in these patients. Studies have demonstrated reduced incidences of VTE with extended thromboprophylaxis using low molecular weight heparins (LMWH) and guidelines recommend continuing thromboprophylaxis after discharge in patients who have undergone major cancer surgery, but the evidence is still considered limited and of low quality, and the recommendations have not been widely


some as a preventative and cure for cancer. Cancer Research UK states "we don't support the use of macrobiotic diets for people with cancer".
 McDougall diet  – a restrictive low-fat, starch based vegan diet devised by John A. McDougall. The diet is low in fat, high in fiber and contains no cholesterol. McDougall has promoted the diet as an alternative treatment for a number of chronic disorders, including cancer. However, there is no scientific evidence that McDougall's diet is effective.
 Moerman Therapy – a highly restrictive diet devised by Cornelis Moerman (1893–1988). Its effectiveness is supported by anecdote only – there is no evidence of its worth as a cancer treatment.
 Superfood – a marketing term applied to certain foods with supposed health-giving properties. Cancer Research UK note that superfoods areAlthough it is promoted as effective for curing a number of human ailments, including cancer, the American Cancer Society says "available scientific evidence does not support claims that polarity therapy is effective in treating cancer or any other disease".
 Rife Frequency Generator – an electronic device purported to cure cancer by transmitting radio waves. Cancer Research UK state, "there is no evidence to show that the Rife machine does what its supporters say it does".
 Therapeutic Touch (or TT) – contrary to its name, a technique that does not usually involve touching; rather, a practitioner holds their hands close to a patient to affect the "energy" in their body. According to the American Cancer Society, "available scientific evidence does not support any claims that TT can cure cancer or other


sickness. The therapy has also been promoted as a cure-all for a wide range of conditions, including cancer, for which there is no evidence of effectiveness.
 Insulin potentiation therapy – the practice of injecting insulin, usually alongside a low dose of conventional chemotherapy drugs, in the belief that this improves the overall effect of the treatment.  Although it may cause a temporary reduction in tumor size for some patients, there is no evidence that it improves survival time or any other main outcomes.
 Krebiozen (also known as Carcalon, creatine, substance X, or drug X) – a mineral oil-based liquid sold as an alternative cancer treatment. According to the American Cancer Society: "Available scientific evidence does not support claims that Krebiozen is effective in treating cancer or any other disease.Q:

Scanner with just a File VS Scanner with FileReader and File

Guys i'm just wandering what is the difference between these lines

Scanner file = new Scanner(new FileReader(new File(filePath)));
Scanner file = new Scanner(new File(filePath));
Scanner file = new Scanner(new FileReader(filePath));

is their any kind of instance when you will use them? or their all the same?

A:

They're all identical.  The File constructors are for convenience.  Sometimes you will get other Readers (not from a File) or need to construct the FileReader yourself (in order to specify an encoding) in which case the Reader constructor is important.


31 Cats That Look Like Other Things

Remember when we wrote about dogs that look like something else? Now it’s the cat’s turn to shine. Here is a list of cats that got bored of looking like cats and decided to look like something else instead.

Cats are the biggest divas on the internet, so there’s no way we’ve got all the shape-shifting felines in the world in this list.guidelines of TCGA.

### Preprocessing of microarray data and differentially expressed mRNA screening

Raw microarray datasets from GEO database were normalized using Robust Multichip Average (RMA) and transformed to Log2 pattern for processed signals. Probes were annotated by using the Affymetrix annotation files ([@b9-or-43-02-0379]). Then, the differentially expressed genes (DEGs) between primary NMIBC and progressive NMIBC specimens from training set (GSE13507) were screened with the use of DESeq R package. When adjusted P-value \<0.05 and \|Log2 (FC)\|\>1, the genes were regarded as DEGs, the expression profiles of which are listed in [Table SI](#SD1-or-43-02-0379){ref-type="supplementary-material"}.

### Development and validation of the gene signature

Univariate Cox regression analysis was utilized to investigate the prognosis-related DEGs. The gene was considered significant when P-value \<0.05, and 47 candidates qualified, through which the LASSO Cox regression was employed


the training dataset ([Fig. 6B](#f6-or-43-02-0379){ref-type="fig"}), and the performance of the nomogram on prediction accuracy was also excellent in the validation dataset ([Fig. 6C](#f6-or-43-02-0379){ref-type="fig"}). Time-dependent ROC curves indicated that the AUCs at 3- and 5-year were 0.929 and 0.88 for the nomogram in the training dataset ([Fig. 6D](#f6-or-43-02-0379){ref-type="fig"}). ROC analysis showed a 0.903 of AUC for the nomogram in the validation dataset ([Fig. 6E](#f6-or-43-02-0379){ref-type="fig"}).

### Comparison of the 13-mRNA signature with other progression-related biomarkers for NMIBC

Several studies have attempted to develop biomarkers for predicting disease progression in NMIBC during the past couple of years. We compared the diagnostic efficacy of the 13-gene classifier to that of other published biomarkers in the GSE13507 and GSE120736 cohorts to comprehensively evaluate the model\'s practical applicability. The published biomarkers included mRNA signatures and singlein MIBC tissues ([Fig. 11C](#f11-or-43-02-0379){ref-type="fig"}), and high CTHRC1 expression was observed in the majority of MIBC tissues (22/34) while in part of non-invasive tumors (5/15), which was consistent with the result of RT-qPCR and the trend seen in the GEO datasets. Detailed information about clinical specimens is listed in [Table IV](#tIV-or-43-02-0379){ref-type="table"}. Furthermore, functional assay indicated that CTHRC1 knockdown inhibited migration ability of 5637 and TCCSUP cells ([Fig. S1](#SD1-or-43-02-0379){ref-type="supplementary-material"}), suggesting CTHRC1 may be involved in the development and progression of bladder cancer.

Discussion
==========

Comprehensive genomic studies on high-throughput RNA sequence and microarray profiles have attracted considerable attention for the prognostic prediction and exploration of molecular mechanisms of a variety of diseases in recent years. Progression of NMIBC to MIBC has been an unsolved life-threatening problem, and cannot be accurately predicted with


the use of traditional clinicopathological parameters ([@b15-or-43-02-0379]). Thus, identification of good sensitive and specific novel biomarkers for predicting disease progression of patients with NMIBC is of utmost clinical significance in treatment decisions and follow-up regimens. In the current study, a 13-mRNA signature was developed for both prediction of disease progression and survival prediction of patients with bladder cancer. Moreover, this model outperformed other published gene signatures and biomarkers in two GEO datasets included in the present study, demonstrating its considerable reliability and robustness in predictive accuracy.

In total, 73 DEGs were identified between patients with primary NMIBC and patients with progressive NMIBC, and univariate Cox regression analysis was used to screen 47 prognostic genes from those DEGs. However, this method is not suitable for such high-dimensional microarray data dueconsent for publication
===============================

Not applicable.

Competing interests
===================

The authors declare that there are no conflicts of interest.

![Overall workflow diagram for the development and validation of prognosis-related mRNA signature.](OR-43-02-0379-g00){#f1-or-43-02-0379}

![Identification and construction of NMIBC progression-related 13-mRNA classifier. (A) The heat map of the expression levels of 73 differentially expressed genes in the training dataset. (B) LASSO coefficient profiles of the 47 prognosis-associated mRNAs. Ten-time cross-validation was exhibited for tuning parameter selection and a vertical line was drawn at the value of the minimal λ used for establishment of 13-mRNA classifier. (C) The optimum cut-off value of the gene signature based risk scores was produced using the X-tile program in the GSE13507 training cohort. Red shows inverse association, while green indicates direct association between risk score and progression-free survival.](OR-43-02-0379-g01){#f2-or-43-02-0379}

![Analysis of the 13-mRNA signature in


curves of OS in different subgroups stratified by (D) AJCC stage, (E) age and (F) tumor subtype.](OR-43-02-0379-g04){#f5-or-43-02-0379}

![The established nomogram to predict the risk of NMIBC progression. (A) The nomogram was generated in the training dataset, with gender, grade and 13-mRNA signature incorporated. (B) Calibration curves of the nomogram to predict PFS at 3- and 5-year in the training dataset. (C) Calibration curves of the nomogram in the validation dataset. The actual diagnosed disease progression is plotted on the y-axis; nomogram predicted probability is plotted on the x-axis. (D) Time-dependent ROC curves based on the nomogram for 3- and 5-year PFS in the training dataset. (E) ROC curves based on the nomogram in the validation dataset.](OR-43-02-0379-g05){#f6-or-43-02-0379}

![ROC analysis of 13-mRNA signature and other published single gene or multi-gene models insaid Kirchner was involved in the company's junior firefighter program for children ages 14-16, which included two of the chief's children.

"My kids really liked the guy. He took an interest in them," Robinson said. "He was in a family that's steeped in tradition related to the fire service."

After KIrchner was posthumously awarded the department's Medal of Honor by County Executive Kevin Kamenetz and fire Chief John J. Hohman, sister Shelly Brezicki spoke for the family. A volunteer firefighter herself, Brezicki told firefighters and civilians that "Green Gene" was the family peacemaker and a young man who could always be counted on to take his mother to bingo.

"Rest in peace, my little brother," she said from behind the flag-draped casket.

When the service ended, the coffin was wheeled out of


and choose a huge brush that's soft edged. We're going to erase in the highlights!

Step 9

I see a lot of kids asking how to digitally shade eyes to where it looks glossy like marbles or silver. First, begin with a basic color. Get a darker color and shade almost halfway. Then, take an airbrush or soft brush, and highlight with a lighter - saturated tone. Next, add a few dabs of lighter tones that offset the previous. Lastly, take your 'Lasso Tool' and select an area above the shadow, and lightly paint over it to create a glass effect. Don't forget those sweet spots of highlight as well!

Step 10

To complete our adventure of shading Lugia, let's start adding reflective light to create the appearance that he's basking inisn't confused by normal env stuff. What exactly is it doing?

A:

The documentation for this feature is found in perlrun.

If the #! line does not contain the word "perl" nor the word "indir", the program named after the #! is executed instead of the Perl interpreter. This is slightly bizarre, but it helps people on machines that don't do #!, because they can tell a program that their SHELL is /usr/bin/perl, and Perl will then dispatch the program to the correct interpreter for them.

So, if the shebang contains perl or indir, the interpreter from the shebang line isn't executed.
Additionally, the interpreter from the shebang line isn't executed if argv[0] doesn't contain perl. This is what prevents the infinite loop in your example.

When launched using perl /tmp/pscript,

the kernel executes perl


manner in which the mishap occurred. Moreover, in the present case where it is charged the carrier did not use due care to protect its insured because of the failure to visit this boy, attention is drawn inevitably to the fact that neither the plaintiff nor its driver nor experienced trial counsel produced him at the trial. He was known to them and if he knew anything which would have supported their suit, it is difficult to believe he would not have been brought in as a witness. If there are any inferences to be drawn at all, in the light of the nature of the criticism of the insurer, they must be adverse to the plaintiff. If it was negligence for the insurer not to interview theinvestigation and good faith in dealing with offers of settlement. The ultimate question is not whether a verdict in excess of the policy limits should have been anticipated but whether the insurer lacked good faith in deciding not to meet the settlement demand. Mere failure to settle within the policy limit when there was an opportunity to do so before or during trial is not evidence of bad faith. Appleman, supra, § 4711, p. 73. The fact that the policy limit was exceeded by the verdict, in the light of hindsight may indicate a mistake of judgment. But such a mistake when resulting from a decision made with good faith regard for its own and the insured's interests does not confer a cause of action on the insured


it justify its judicial rejection without calling upon the defense for its testimonial version of the circumstances; and it ignores the many decisions in our State which hold that where there are inconsistencies in the plaintiff's case it is nonetheless entitled, on a motion for dismissal, to the benefit of "so much of the evidence" as is favorable to its claim. See Kozlowski v. Pavonia Fire Ins. Co., 116 N.J.L. 194, 200 (E. & A. 1936); Repasky v. Novich, 113 N.J.L. 126, 129 (E. & A. 1934); Weinstein v. Weinstein, 10 N.J. Super. 68, 72 (App. Div. 1950).
It is admitted that the injured party had duly made an offer of settlement in the sum of $3,600. The offer was, *315 summarily and without counter proposal at any time,offer its investigator as a witness; indeed its only witnesses were the assured's driver who was a highly interested defendant in the proceeding and its doctor who was hardly in any position to controvert the testimony by the injured party's treating physicians as to the permanency of her elbow injury because, as he testified, he never made any diagnosis of the elbow injury. A jury could undoubtedly find from the trial transcript that the testimony weighed heavily in favor of the injured party on both issues of liability and damages; in this connection it is interesting to note that when Judge Hughes refused to interfere with the jury's verdict of $13,500 against the assured and its driver, he expressed the view that "there was a lopsided case here


the driver's statement to the contrary and the probabilities before a jury on the issue of liability; and if at that time the claims manager had considered the injured party's claim of probable permanent damage and had made inquiries as to the testimony which could be expected from her treating physicians he would have been in a position to evaluate the insurance company's medical report and the probabilities before a jury on the issue of damages. But unfortunately the young boy was never interrogated by the insurance company and by his own admission the claims manager did not know of the statement *320 by the disinterested witness when he rejected the settlement offer and did not at that time consider the plaintiff's claim of probable permanent damage orproves Ham doesnt fundamentally understand what the theory of evolution actually is.

Another user, trueBlonde made a great observation about one of Ham’s primary arguments:

So far it seems Ken Ham is proving that creationists can be scientists, not that creationism is a viable scientific explanation.

Finally, a Redditor called BrownNote was remarkably impressed by one of Nye’s questions:

BILL JUST TURNED IT UP TO 11. “I have a question for you, Mr. Ham. What can you prove? All you’ve done tonight is come up with explanations, this is very troubling to me.” No more Mr. Nice Nye.

Back to the Richard Dawkins Foundation, here are some alternative counter-arguments as to why the debate was a good idea after all.

The credibility issue

Before the debate, only creationists were the ones calling themselves credible and


be said, I feel as a rationalistic community we need to begin distancing ourselves from the term ‘atheists’ (and all the other reductive labels), i get that we aim to be rational and scientific, etc. I get that we have debunked the creationist’s point of view, furthermore we can safely say there is not a man with a grey beard in the clouds, I get the meaning of the term atheism as well. However that puts a religious (or areligious) connotation on this whole way of thinking and being. It seems that those words just cause divisiveness, and strays us away from the main important point of furthering discovery and science. I am neither a believer nor disbeliever, off the basic fundamental understanding that I simply don’t know,

WikiLeaks Cable: NASDAQ Folded to Chinese Regime's Pressure - jjp9999
http://www.theepochtimes.com/n2/world/chinese-regime-demanded-nasdaq-eject-network-wikileaks-cable-says-181131.html

======
unreal37
No matter your personal opinion of the Wikileaks organization or Julian
Assange, or the American-led dismantling and prosecution of them, these US
govt cable leaks had to have been the greatest treasure-trove of leaked
information ever, in history.

Journalists will be reading through the pile for years and perhaps decades,
finding tidbits of truth and exposing government and corporate deceits.

I do somewhat feel bad for the soldier who I believe is facing life in prison
for exposing these classified files. But it definitely was for the good of all
humanity.

Truth wins in the end.

~~~
ars
Hyperbole much?

These leaks were a dud, there was very little that was interesting in them.
The only thing special about them was how large the leak was.

NASDAQ bowing to pressure? OK, I guess. But


so the outlets come up from below in the main tank, gotta have check valves you can trust if you don't have a canister filter I'd suspect. Evaporation would be a definite issue. I'd be tempted to try to build a small one and just run it when I know I'll have guests, throw a couple of orandas it it that I'd normally keep elsewhere, so there'd be something cool to look at, don't know if I'd want to deal with it full time.

they are actually very easy to build and infinity tank, I was thinking of building one myself for fresh water, I still might yet. I would put the stand pipes in the middle for your returns and design some kind of comb to keep the= 573259391;  // 30 M'th prime
    ml = 373587883;  // 20 M'th prime
    mu = 275604541;  // 15 M'th prime
    // Each of the above primes is at least 10^8 i.e. at least 24 bits
    // so we are assured that the initial value computed below occupies 64 bits
    // and then the subsequent operations help ensure that every bit is affected by
    // all three inputs.

    bits = ((unique * mu + i) * mi + j) * mj;  // All multipliers are prime
    bits = (bits ^ (bits >> 32)) * mk;
    bits = (bits


       success = false;
            } else if (!(0 <= ri &&
                         (t.is_min((int64_t)bi) || ri < (T)std::abs((int64_t)bi))) &&
                       (ecount++) < 10) {
                std::cerr << "ri is not in the range [0, |b|); a, b = " << (int64_t)ai
             (target.has_gpu_feature()) {
        scheduling = TiledGPU;
    } else if (target.features_any_of({Target::HVX_64, Target::HVX_128})) {
        scheduling = Hexagon;
    }

    // Test multiplication
    std::vector<int> mul_vector_widths = {1};
    if (target.has_feature(Target::Metal) ||
        target.has_feature(Target::D3D12Compute)) {
        for (int i = 2; i <= 4; i *= 2) {
            mul_vector_widths.push_back(i);
        }
    } else if (target.has_feature(Target::OpenGLCompute)) {
        // Vector load/store unimplemented
    } else if (target.has_feature(Target::HVX_64))


to Sue letter. (Agola Decl. ¶ 3 & Ex. A.) The EEOC charge contains details of the same masturbation incident described in the complaint. In her responsive papers to Defendants' motion, Plaintiff does not object[4] to the Court's consideration of the Kleehammer Special Report and the Sommers Letter to Kleehammer. Likewise, in their reply, Defendants did not object to the Court's consideration of the documents submitted by Plaintiff in her response. Accordingly, the Court, in addition to the subject complaint, will consider the Kleehammer Special Report, the Sommers Letter to Kleehammer, the EEOC complaint *180 and Right to Sue letter in adjudicating the motion.

STANDARDS OF LAW

Fed.R.Civ.P. 12(c)
In deciding a Rule 12(c) motion, the Court applies the same standard used for a Rule 12(b)(6) motion. Burnette v. Carothers, 192shall be imposed . . . against an attorney and/or his client when it appears that a pleading has been interposed for any improper purpose, or where, after reasonable inquiry, a competent attorney could not form a reasonable belief that the pleading is well grounded in fact and is warranted by existing law or a good faith argument for the extension, modification or reversal of existing law.
Eastway Const. Corp., 762 F.2d at 254. The Court will not hesitate to consider sanctions if warranted.

CONCLUSION
For the reasons stated above, the Court grants Defendants' application (Docket No. 9) is granted in part and denied in part. The Third and Fourth causes of action alleging retaliation under Federal and State law may go forward. The remaining causes of action are dismissed.
IT IS


set of facts in support of his claim which would entitle them to relief." (Pl.'s Mem. of Law, at 3.)
[6]  The Fourth Amendment reads, "The right of the people to be secure in their persons, houses, papers, and effects, against unreasonable searches and seizures, shall not be violated, and no Warrants shall issue, but upon probable cause, supported by Oath or affirmation, and particularly describing the place to be searched, and the persons or things to be seized." It is not clear from Plaintiff's papers exactly how she pleads a claim under this Amendment.
[7]  "[T]he antiretaliation provision, unlike the substantive provision, is not limited to discriminatory actions that affect the terms and conditions of employment." Burlington Northern and Santa Fe Ry. Co. v. White, 548 U.S.her colleagues used mtDNA genomes from about 1,200 people with the L0 lineage and used the results to build a "family tree." This tree calculated when each branch of the L0 lineage split off—in other words, every time a group of women moved away from the rest of their maternal relatives.

According to Chan and her colleagues, the oldest branches of L0 formed between 165,000 and 240,000 years ago. Their findings also assert that two major branches split off around 130,000 years ago and 110,000 years ago, respectively (there are lots of smaller branches involved, but we can focus on the big ones).

But the researchers wanted to know where (not just when) early humans moved around. So they mapped where each branch of the mtDNA "family tree" (which scientists


anywhere. Different groups of early humans, scattered around the continent of Africa, had different combinations of "modern human" features. But, in all likelihood, nobody had the full set of physical traits that we think of as defining modern humans until between 100,000 and 40,000 years ago.

Based on genetic and fossil evidence, it seems most likely that that combination of traits took shape gradually, as diverse groups of early humans scattered around Africa interacted with each other over a few hundred thousand years. "Is there even any point in attempting to identify a specific locale of origin given that this is unlikely to tell the whole story?" asked archaeologist Patrick Roberts of the Max Planck Institute for the Science of Human History.

University of Wisconsin paleoanthropologist John Hawks suggested thatthe study might still contribute a piece of the larger story of human origins. "This new evidence from mtDNA is useful, and maybe it tells part of the story. It may give us some of the best reason so far to think that southern Africa played a key role in the earliest evolution of humans," he told Ars. "But it's too soon to say whether that is the original homeland of humans or whether there was a broader involvement of much of the continent."

DNA studies aren’t always the perfect tool

Part of the problem is the study's emphasis on mtDNA, which can only tell part of the story. In particular, mtDNA only tells you about half of your ancestry for each generation, and it changes rapidly enough that things


Study finds rules for cancer drivers

By Veronica Meade-Kelly, Broad Communications,
September 27th, 2013

The Broad's Genome Characterization Center has taken the lead in analyzing copy number alterations for The Cancer Genome Atlas (TCGA) Project.Image courtesy of The Cancer Genome Atlas Project, National Institutes of Health

Cancer has come to be known as a “disease of the genome.” Any number of alterations to an individual’s genetic code – the sequence of As, Cs, Gs, and Ts that serve as our biological blueprint – has the potential to make a cell malfunction and proliferate into cancer tumors. Identifying the genetic changes that lead to cancer – and the rules that govern those changes – has been a key goal in the field of cancer genomics. It is a task made more challenging byinvestigator of the study and a co-senior author of the paper. Beroukhim is an associate member of the Broad, and an assistant professor at Dana-Farber Cancer Institute and Harvard Medical School.

The team found that, across cancer types, somatic copy number alterations adhered to the following rules:

Whole-genome doubling is associated with higher rates of every other type of copy number alteration. Whole-genome doubling is one of the major sources of copy number changes in tumors, occurring in about 37% of cancers. As the term suggests, it happens when the entire genome of an organism duplicates, so instead of producing the usual two of each chromosome, a person will produce four. The GCC study found that, in cancer, whole-genome doubling tends to trigger additional copy number alterations. The team found


140 regions of the genome that seem to be affected by somatic copy number alterations. Across all 12 cancer types examined in the study, these 140 regions were consistently altered. Of these regions, only 35 contained genes that were previously linked to cancer. The remaining regions house a large number of new candidate genes that may prove to be cancer drivers.

SCNAs can affect the epigenetic regulators that control how genes are expressed, contributing to cancer. Many of the 140 regions identified by the study are known to contain epigenetic regulators. These regulators modify how DNA is folded within the cell and what parts of the DNA’s genetic code can be read, which in turn affects how genes are expressed. This evidence suggests that some cancer patient populations mayis conveyed through one or more transfer rollers to the non-image areas of the rotating plate cylinder. The plate cylinder rotates in contact with a blanket cylinder which transfers the ink image from the plate cylinder to the moving paper web.
It is readily apparent that the amount of ink and dampening water supplied to the plate cylinder is directly proportional to the press speed. At higher press speeds the plate cylinder and blanket cylinder transfer ink and water to the paper web at a higher rate, and the inking and dampening systems must, therefore, supply more ink and water. It is also well known that this relationship is not linear and that the rate at which ink and dampening water is applied follows a complex rate curve which


of the GNU General Public License
 *  along with GRUB.  If not, see <http://www.gnu.org/licenses/>.
 */

#include <grub/machine/memory.h>
#include <grub/i386/memory.h>
#include <grub/memory.h>
#include <grub/err.h>
#include <grub/misc.h>
#include <grub/mm.h>

#ifndef GRUB_MMAP_REGISTER_BY_FIRMWARE

/* Context for grub_mmap_malign_and_register.  */
struct grub_mmap_malign_and_register_ctx
{
  grub_uint64_t align, size, highestlow;
};

/* Helper for grub_mmap_malign_and_register.  */
static int
find_hook (grub_uint64_t start, grub_uint64_t rangesize,
	   grub_memory_type_t memtype, void *data)
{
  struct grub_mmap_malign_and_register_ctx *ctx = data;
  grub_uint64_t end = start + rangesize;

  if (memtype != GRUB_MEMORY_AVAILABLE)
    return 0;
  if (end > 0x100000)
    end = 0x100000;
  if (end > start + ctx->size
      && ctx->highestlow < ((end - ctx->size)
			    - ((end - ctx->size) & (ctx->align - 1))))
    ctx->highestlow = (end - ctx->size)
		      -try not to let the negative ruin your day.

You could report a hit and run if the driver left the scene, but with no damage to your bike, and luckily to you, the police won't make a priority out of it, and if the driver denies it, it's your word against theirs.

The OP did fine.

The cops had the license plate. All they had to do was run the plate and visit the dumb ass driver and explain what the max fine and jail time the JAM could spend in jail if the cyclist decides to prosecute.

Then, if there are any further incidents with bicyclists, or other drivers, or his wife/girlfriend, or his coworkers, etcetera, there will be a consistent pattern of aggressive behavior revealed to the authorities.

There may


3Transcriptional response of *wt* and *gcn5*Δ/Δ cells upon caspofungin stress. Total RNA was isolated from cultures of SC5314 wild-type (*wt*) and homozygous deletion strain (*gcn5*Δ/Δ) grown in the absence or presence of caspofungin and subjected to RNA-seq analysis. The bioinformatics pipeline for data analysis and hierarchial clustering is described in materials and methods. (**A**) Genetic removal of *GCN5* increases caspofungin susceptibility. Growth of indicated strains in YPD containing or lacking 10 ng/ml caspofungin (CSP10) at 30 °C. Data represent the means from three independent growth analyses (±SEM). Solid and dotted lines indicate untreated and caspofungin-treated cultures, respectively. (**B**) Heat map of hierarchical clustered and differentially expressed genes in *wt* and *gcn5*Δ/Δ cells in response to caspofungin treatment (CSP). Lanes 1 and 2 compare 15 min and 45 min CSP-treated *wt* cultures withMeier survival method was applied (**\***p \< 0.05). (**C**) Logarithmically growing cells of SC5314 wild-type (wt), homozygous deletion (*gcn5*Δ/Δ) and restored (*gcn5*Δ/Δ::*GCN5*) Candida strains were used for infecting primary bone marrow-derived macrophages (BMDMs) at a multiplicity of infection (MOI) of 10:1 (fungi to macrophages). Fungal cells were harvested 2 h and 4 h post infection and viability quantified by cfu-counting on YPD plates as described in materials & methods to calculate the percentage of survival after 48 h incubation. Data represent the mean of three independent experiments (±SEM, **\***p \< 0.05). (**D**) Confocal microscopy images of Alexafluor 488-labeled SC5314 wild-type (*wt*), homozygous deletion (*gcn5*Δ/Δ) or restored (*gcn5*Δ/Δ::*GCN5*) Candida strains infecting primary bone-marrow derived macrophages (BMDMs) at an MOI of 5:1 (fungi to macrophages). At 45 minutes post infection, cells were stained with Lyso Tracker Red DND-99


visitors feel like they're walking through a forest. It's all displayed on "a pure white floor."

But overall, the presentation isn't nearly as visual or high-tech as last year's display.

Ive teamed up with industrial designer Marc Newson for the project. The pair previously worked together in 2013 to create a customized grand piano and Leica digital camera in support of the HIV/AIDS charity (RED).

"There are few things more pure and beautiful than nature, so that was our starting point, layering various iterations of organic forms with technology," the duo said in a joint statement.

"Our aim was to create an all-enveloping magical experience that celebrates our enormous respect for tradition while recognizing our excitement about the future and things to come."

Because nothing says excitement about the future like a dark,can be appreciated in Fig. [SI-1](#MOESM1){ref-type="media"}; in particular, the patterns do not show any peak shifts compared to the starting HA suggesting that the crystal phase and the structure of the HA material is not affected by the presence of β-lactam molecules.

Figure [5](#Fig5){ref-type="fig"} reports the ATR-FTIR spectra of the azetidinone-HA samples. The spectra display the O-H stretching and bending modes of hydroxyapatite at 3572 and 630 cm^−1^ respectively, the strong bands due to phosphate absorption in the 550--630 and 900--1100 cm^−1^ regions and the bands typical of the azetidinone molecules. In all the spectra the position of the azetidinone bands allows to recognize the specific functional groups. As an example, Fig. [5](#Fig5){ref-type="fig"} (right) reports the band assignments for **2a-HA**: aliphatic C-H stretching vibrations in the 2900 cm^−1^ region, C=O stretching of β-lactam, acetoxy groups


significant morphological variation has been observed after azetidinone loading, as shown in Fig. [6](#Fig6){ref-type="fig"} for samples **1a-HA** and **2a-HA** compared with pure HA.Figure 6TEM images of HA, **1a-HA**, and **2a-HA** nanocrystals. Scale bar = 200 nm. All images have the same magnification.

Antibacterial susceptibility testing against reference bacterial strains {#Sec6}
------------------------------------------------------------------------

The *in vitro* antibacterial activity was studied for **1a-HA**, **1b-HA**, **2a-HA**, and **2b-HA** samples (not for **1-HA** and **2-HA** because **1** and **2** are inactive as antibacterial agents)^[@CR27]^. The antibacterial activity was examined by the KB disk diffusion test in which the area of clear media around the disk (Ø = 6 mm) indicates the degree of sensitivity of the strain expressed in millimeters. The reading and interpretation of the agar plates were made following 24 h of incubation at 37 °C. When zones of inhibition were present aroundamounts by a proper choice of the polarity of the loading solution. The characterization of the HA composites revealed the presence of intact β-lactams which could exert their biological activities. The release of azetidinones from HA composites depends on the lipophilicity of the molecule. The more lipophilic ones showed a low release which allows to maintain high local concentration of the antibacterial agent along the metabolic cycle of HA. Functionalization of biomimetic apatites by antibacterial agents active against resistant bacterial strains is important for the elaboration of bioactive bone-repair materials. All the new azetidinone-HA composites were successfully tested for antibacterial activity against reference strains. In particular, **1a-HA** sample, which displayed no cytotoxicity towards MG63 osteoblast-like cell line, showed excellent potency against a set of MSSA and MRSA-SCV clinical


on their antimicrobial susceptibility to methicillin. The tested strains were isolated on BD Columbia Agar with 5% sheep blood (Becton Dickinson, Germany) and confirmed by MALDI-TOF MS (Bruker Daltonik, Germany)^[@CR44]^. Their susceptibility was analyzed by the Vitek2 semi-automated system (bioMerieux, France) and interpreted following EUCAST guidelines. MRSA strains were confirmed by growth on BD oxacillin screen agar (Becton Dickinson, Germany), as in the clinical microbiology laboratory resistance to oxacillin is the marker for detecting methicillin resistance^[@CR45]^. SCV phenotypic characterization was carried out by identification of very small pinpoint colonies on blood agar plate following 48 h of growth.

### Kirby-Bauer (KB) disk diffusion method {#Sec23}

The assay was performed following the requirements of the CLSI 2006) and allowed to measure the diameter of the inhibition zone (in millimeter) surrounding the azetidinone-HA                                                      Lewis, 2017 (*Soc Sci Med*)\*

  **Stream 2:** Health IT Use by ACOs                             Many ACOs report having an EHR or HIE capabilities but specific advanced capabilities are generally reported by fewer than 50% of ACOs.


information on the type of organization (aside from skilled nursing facilities), number of shared beneficiaries, and organization identifiers that are linkable to other datasets such as NSACO and AHA. Finally, the use of EHD has been limited. Using EHD may add complexity to analyses, but holds the potential to more directly assess patient outcomes and clinical indicators of population health.

Application of Theory
---------------------

Most of the studies we identified did root their analyses in theoretical frameworks. Researchers use specific ACO frameworks or ground their hypotheses in organizational theories such as resource dependence theory \[[@B17]\]. ACOs constitute a highly complex field with different organizational structures, varied financial incentives across and within ACOs, and diverse patient populations. Due to this complexity, grounding research in theory is important both for understanding applicability tocontinued use of theory in this body of literature is important for both interpretation and applicability of the findings to inform ACO decisions and advance the evidence base. Furthering the evidence-base of the effects of health IT within the context of ACOs is increasingly relevant to the ongoing discussion surrounding delivery reform.

Additional File
===============

The additional file for this article can be found as follows:

10.5334/egems.261.s1

######

Appendix Table 1 includes the search strategy for the systematic review. Appendix Table 2 describes findings of each study by research stream identified in the review.

We would like to thank Margo Edmunds, PhD and Liz Koechlein for their support through the AcademyHealth student competition from which this project evolved. We would also like to thank David Padgham for his review of an early draft of


It didn’t take long Friday night before Washington Wizards point guard Isaiah Thomas was ejected from the team’s home game against the Portland Trail Blazers.

Less than two minutes into the NBA game, Thomas became tangled with Portland’s Carmelo Anthony – then made contact with referee Marat Kogut while trying to break free.

As a result, Thomas received a technical foul and was ejected.

WASHINGTON WIZARDS' ISAIAH THOMAS CONFRONTS FAN IN STANDS WHO GIVES FINGER, CURSES AT HIM

“He made physical contact with the referee,” referee Mark Ayotte said in a report after the game. "It was definitely just a push during the dead ball contact with the referee.”

Wizards coach Scott Brooks thought the contact was accidental.

“I mean I had a different view of it obviously," Brooks told The Associated Press. "TheyNecessarily all and only creatures with a heart are creatures with kidneys.

Presuming that 'creature with a heart' and 'creature with kidneys' have the same extension, they will be interchangeable salva veritate. But this interchangeability rests upon both empirical features of the language itself and the degree to which extension is empirically found to be identical for the two concepts, and not upon the sought for principle of cognitive synonymy.

It seems that the only way to assert the synonymy is by supposing that the terms 'bachelor' and 'unmarried man' are synonymous and that the sentence "All and only all bachelors are unmarried men" is analytic. But for salva veritate to hold as a definition of something more than extensional agreement, i.e., cognitive synonymy, we need a notion of necessity


between the analytic and the synthetic". For Quine, every change in the system of science is, when rational, pragmatic.

Rudolf Carnap prepared a reply entitled "Quine on Analyticity", but this was not published until 1990. Addressing Quine's concern over the status of the sentence "Everything green is extended", Carnap wrote "the difficulty here lies in the unclarity of the word 'green', namely in an indecision over whether one should use the word for something unextended, i.e., for a single space-time point. In daily life it is never so used, and one scarcely ever speaks of space-time points." Carnap then puts forward that an exact artificial language ought to clarify the problem by defining 'green' (or its synonym) as something that is either necessarily or contingently not applied to space-timeone of them is the true answer to the same question asked of the other. They also draw the conclusion that discussion about correct or incorrect translations would be impossible given Quine's argument. Four years after Grice and Strawson published their paper, Quine's book Word and Object was released. In the book Quine presented his theory of indeterminacy of translation.

In "'Two Dogmas' revisited", Hilary Putnam argues that Quine is attacking two different notions. Analytic truth defined as a true statement derivable from a tautology by putting synonyms for synonyms are near Kant's account of analytic truth as a truth whose negation is a contradiction. Analytic truth defined as a truth confirmed no matter what however, is closer to one of the traditional accounts of a priori. While the


Kellie Pickler Picture 7
7/74

Kellie Pickler

Former American Idol contestant Kellie Pickler has turned her 15 minutes of fame into a thriving career. Her hotly anticipated debut album, Small Town Girl, was released on October 31, 2006. She followed that up with 2008's Kellie Pickler, and she's currently on the road opening for Taylor Swift.In 1897, in retaliation for the ambush of an ill-advised British diplomatic mission to the Kingdom of Benin in Nigeria, Britain attacked the capital. During the subsequent conquest, which marked the end of the Old Kingdom, thousands of sculptures were confiscated as “barbaric” and sent to Europe. The Menil’s tusk was among over 130 similar full-length carved ivories that were seized at that time. Few records were kept to describe the source of any of the artworks that were removed from Benin, but certain facts can be assumed about this tusk based on Benin’s customs, oral history, and the motifs carved upon its surface. It was apparently part of a memorial shrine established in the late eighteenth century by an extremely wealthy ezomo, the highest-ranking hereditary war captain


help each other. Sometimes it’s very difficult for me and I’m sure for others to wait for somebody to respond to a reply when they’re at that particular moment going to pure panic. Didn’t see it at such a big deal, I have no issues of anyone knowing who I am since I can be publicly looked at the Google, and I’m actually considered a public figure. Sometimes it’s very difficult for me and I’m sure for others to wait for somebody to respond to a reply when they’re at that particular moment going to pure panic. Didn’t see it at such a big deal, I have no issues of anyone knowing who I am since I can be publicly looked at the Google, and I’m actually consideredQ:

How to make shape like this using border radius?

What i have made so far is here http://jsfiddle.net/cmRHp/1/

13.3"

and i want to make exactly like this

A:

Those aren't actual rounded borders, so you probably have to use 2 elements.

.tv {
  position: relative;
  width: 200px;
  height: 150px;
  margin: 50px auto 0;
  background: black;
  color: white;
  font: bold 300%/3.6 sans-serif;
  text-align: center;
  border-bottom-right-radius: 15px 70px;
  border-top-right-radius: 15px 70px;
  border-top-left-radius: 15px 70px;
  border-bottom-left-radius: 15px 70px;
}
.tv-inner {
  background: black;
  height: 180px;
  margin: 0 15px;
  position: relative;
  top: -15px;
  border-bottom-right-radius: 70px 15px;
  border-top-right-radius: 70px 15px;
  border-top-left-radius: 70px 15px;
  border-bottom-left-radius: 70px 15px;
}

13.3"

http://jsfiddle.net/cmRHp/6/


SIIA Report Gives High Marks to Offshore Development

WEBINAR:On-Demand

A new survey shows that companies are increasing their offshore development efforts and rating the deliverables as above average or higher.

The Software & Information Industry Association has published a report on the state of global software development, showing that a vast majority of companies that offshore their development operations report positive impacts on revenues and profits.

For its Global Software Development Survey Report, the Washington D.C.-based SIIA teamed up with Symphony Services, a global product engineering outsourcer, to survey 114 software companies on their use of offshore developers. A majority of respondents said they are achieving between 80 percent and 100 percent of the cost savings goals they set for offshoring.

David Thomas, executive director of SIIA, said the report shows that overall,                  System.out.println("Data mismatch at char: " + i);
                }
            }

            // seek to offset 40.  The KfsInputChannel allows seeking;
            // this is an extension to the basic readablebytechannel api.
            inputChannel.seek(40);

            // Seek and verify that we are we think we


7 (base 8) to base 14.
7
What is 220 (base 3) in base 11?
22
What is 11 (base 2) in base 12?
3
What is -5 (base 7) in base 6?
-5
What is -2 (base 9) in base 11?
-2
Convert 10021 (base 3) to base 11.
80
107 (base 8) to base 12
5b
Convert 4 (base 8) to base 10.
4
-bc (base 14) to base 7
-325
What is 12 (base 11) in base 10?
13
1021 (base 3) to base 16
22
-240 (base 7) to base 2
-1111110
Convert 93 (base 10) to base 11.
85
Convert -2 (base 13) to base 10.
-2
Convert 3 (base 14) to base 15.
3
-13 (base 14) to base 15
-12
-3 (base 13) to base 16
-3
What is -3 (base 16) in base 9?
-3
What is -1 (base 2) in base 16?
-1
Convert -34 (base 9) to base 13.
-25
a2 (base 13) to base 7
246
10 (base 6)(base 15) to base 2.
101101000
What is a9 (base 11) in base 2?
1110111
Convert 147 (base 10) to base 4.
2103
2 (base 8) to base 9
2
Convert -3 (base 6) to base 11.
-3
2 (base 16) to base 2
10
What is 9 (base 13) in base 4?
21
-b (base 15) to base 13
-b
25 (base 7) to base 15
14
What is -16 (base 16) in base 15?
-17
Convert 44 (base 6) to base 5.
103
Convert -1202 (base 3) to base 16.
-2f
What is -16 (base 13) in base 12?
-17
-60 (base 7) to base 10
-42
Convert 1ad (base 14) to base 16.
15d
Convert -7 (base 15) to base 16.
-7
232 (base 5) to base 7
124
What is 26 (base 8) in base 9?
24
-10 (base 12) to base 10
-12
1210 (base 4) to base 16
64
Convert 0 (base 8) to base 11.
0
Convert -1 (base 11) to base 5.
-1
What


(e.g. if I said there was a leaked e-mail saying something), it might be treated more seriously...

--[BTW, did you know that for some reason, your board adds random letters or spaces to my posting? Seems to be at the end of my signature, but also I get spaces elsewhere. I try removing it by updating, and it adds another one (see above for example). Why is that?]--

The only other person who has complained about that is Dickon Prior. Are you using Netscape by any chance?

Originally posted by nepuamun:ahhhhhhhhhhhhhh...... i went through all the trouble in registering just to tell you that that post was HYSTERICAL !!!!!!!!!!!!!!!! and yes, they'll probably sue you !!!!!!

A man talking sense to himself is no madder than a man talking nonsense not tosuggest an article suitable for a socially prominent young lady, thereby creating the same mental picture and, further, both marks have "S" as their initial letter.

Further, the majority states:

18
"Such a mark may become a distinctive indicator of source or origin when so used. However, opposer's record here, except for its registration, contains nothing to indicate that the mark "STYLISH DEBS" has any distinctiveness other than that which attaches specifically to the combined words.

19
"While opposer as a registrant is entitled to rely on his registration and is under no burden to take testimony to prove actual confusion, where, as here, the issue is to be resolved solely by consideration of the two marks, the registration alone gives us no basis to here find that confusion would be likely. [Emphasis


= false; }; ws.onerror = function(e) { console.log('error'); console.log(e); }

Note that not all the functions need to be defined, it’s just easier to spot issues when thing to wrong. Basically what this piece of code does, is that it opens up a websocket connection to “ws://localhost:8889” where our websocket server will be listening. If the connection is successful we set the isOpen to true. Note that we also define a “frame” variable here. This variable is used to keep track of the number of frame we sent and is used on the server side to ensure a correct sequence in the final movie. This piece of code goes at the top of our file and is executed before the rest of the javascript.

When you create animations, you usuallyto note here, is that you should make sure you cal the “sendToServer” after the canvas is rendered. This might seem obvious, but costed me a lot of time bug hunting. I assumed that it wouldn’t matter if I added it before or after, since there is always something rendered on the canvas, and thus available to be sent to the server. Well… this isn’t the case. The canvas is apparently cleared at the beginning of the render loop, which caused a lot of black screens to be sent to the server.

Setup the websocket server

You can use any websocket server you want and for this example I’ve use the vert.x approach, since I’ve been playing around more and more with this great asynchronous server framework. Lets look directly


Background
==========

Male hypogonadism is defined as low serum testosterone under 300 ng/dL that has been considered as one of the major concerns in the modern society \[[@B1]\]. Regarding the possible mechanisms underlying, oxidative stress in the testis serves as the main causal factor actively involved in the pathogenesis of male hypogonadism \[[@B2]\]. Among various etiologies, hypoxia causes oxygen deprivation in the testis contributing to reduced production of androgen, in which a combination with pro-inflammatory factors including ET-1 (endothelin -1), leptin and ROS in initiating testicular abnormalities is likely involved \[[@B3]\]. Oxygen deprivation induces a series of mitochondria dysfunction facilitating an increase of oxidants and a decrease of antioxidants, resulting in an alteration of the redox system, then, oxidative stress occurs \[[@B4],[@B5]\]. In the oxygen deprived condition, an increase inmethods
=====================

Materials
---------

CPU86017-RS (RS), was synthesized by the Center of New Drug Discovery, China Pharmaceutical University and nifedipine (Nif) was purchased from Kangpu Drug Manufacturer, Changzhou, China. The MMLV RT (Moloney Murine Leukemia Virus Reverse Transcriptase; Promega, Madison, WI) and Taq DNA polymerase (Tiangen Biotech, Beijing, China) were purchased from Tianwei Company, Nanjing, China. Monoclonal mouse anti-StAR-IgG, anti-CHOP-IgG, polyclonal rabbit anti-PERK-IgG and anti-Bip-IgG were purchased from Santa Cruz Biotechnology (Santa Cruz, CA); polyclonal rabbit anti-3-beta-HSD-IgG from Novus Biotechnology; HRP-conjugated polyclonal goat anti-mouse IgG and polyclonal goat anti-rabbit IgG from Boster Biological Technology, Wuhan, China

Animals
-------

Adult male Sprague-Dawley rats, weighing 200-220 g, were obtained from The Zhejiang Experimental Animal Center in Hangzhou, Zhejiang Province, with a license No. SCXK20080033. The treatment of rats was strictly conformed to the Guideline of Handling Experimental


in checking the variances of two independent samples an Independent-Sample t-test was used. A probability value of *P*\< 0.05 was considered to be statistically significant.

Results
=======

Testosterone and LH
-------------------

Serum testosterone in the hypoxia group was decreased dramatically by 73.9% (*P*\< 0.01) relative to control. To detect changes in the hypothalamus-pituitary-testis axis (HPT axis), an elevated serum LH was found, up to 596% (*P*\< 0.01) compared to control. An increase of LH was due to the decreased inhibitory activity of serum testosterone on the HPT axis via the negative feedback mechanism. An elevated serum testosterone was responded dose-dependently to CPU86017-RS and Nif in association with a recovery of serum LH (Figure [1](#F1){ref-type="fig"}).

![**Serum testosterone and LH levels**. A reduction in testosterone and an elevated LH in serum were found in rats exploredTesticular LDH. Mean ± SD, n = 10. \**P*\< 0.05, \*\**P*\< 0.01, *vs*. Normal; ^\#^*P*\< 0.05, ^\#\ \#^*P*\< 0.01, *vs*. Hypoxia, ^\$^*P*\< 0.05, *vs*. H+RSL (hypoxia + RS low dose).](1423-0127-19-4-2){#F2}

Histological changes
--------------------

In the normal testis with H+E staining, the multilayered epithelial cells were arranged and packed orderly in the seminiferous tubules, and the reproductive epithelium tightly linked to the basement membrane of the tubules. The lumen of tubules was rich in spermatozoa and the interstitial cells were present in the gap between the tubules. Contorted structures were found in the hypoxia group by showing distorted and decreased layers of reproductive germ cells and far fewer spermatozoa leaving a large cavity at the center of lumen. The skeleton of multilayered epithelial cells and extracellular matrix was seriously disturbed in the


^\$^*P*\< 0.05, *vs*. H+RSL (RS low dose).](1423-0127-19-4-4){#F4}

Bip, PERK and CHOP
------------------

It was interesting to verify if the hypoxic sufferings in the testis were characterized by an entity of inflammatory, thus, we tested the chaperones responsible for developing endoplasmic reticulum stress. An increase in mRNA expression of Bip, PERK and CHOP was signiﬁcant (P \< 0.01) in the hypoxic testes, relative to normal. Protein abundances were upregulated significantly revealing the occurrence of ER stress which represented a status of chronic inflammation in the hypoxic testes. Following interventions, these abnormalities were greatly relieved, in agreement with the aforementioned findings. (Figure [5](#F5){ref-type="fig"}).

![**The expressions of ER stress chaperones**. Upregulation of mRNA and protein expression of Bip, PERK and CHOP were caused by hypoxia in the testes and were attenuated by CPU86017-RS and Nif.A, Bip mRNA; B, Bip protein; C, PERK mRNA; D, PERK protein; E, CHOP mRNA; F, CHOP protein. Mean ± SD, n = 10. \**P*\< 0.05, \*\**P*\< 0.01, *vs*. Normal; ^\#^*P*\< 0.05, ^\#\ \#^*P*\< 0.01, *vs*. Hypoxia, ^\$^*P*\< 0.05, *vs*. H+RSL (hypoxia + RS low dose).](1423-0127-19-4-5){#F5}

Discussion
==========

In the present study, the testis damaged by intermittent hypoxia in rats is characterized by low testosterone and high LH in serum, associated with histological changes in the testis. Under oxygen deprivation, an increase in ROS and RNS has been found as contributing factors for tissue damage \[[@B5]\]. Emerging data indicates that ROS serves as the requisite effector and signaling regulator in facilitating hypoxic Ca^2+^release \[[@B23]\]. Both calcium and ROS are regarded as the key messengers in the dialogue between ER and mitochondria.


grounds and beans, look for those grown using no pesticides. Coffee tends to absorb whatever is in the nearby soil, which greatly affects the flavor of the resulting drink. Coffee grown without the use of pesticides has a better taste.

Coffee Beans

Coffee can last longer when placed in a freezer, but be sure to only keep it there for three months. If it stays there longer, the quality will go down.

If you want coffee that is unrivaled in richness and flavor, buy a French press. The paper filters used in most coffee makers absorb up the oils from coffee beans. A French press works differently. It has a plunger, which shoves coarsely ground coffee beans to the carafe's bottom. The oil remains in the brew. This lends a richercan usually find freshly roasted beans. If your area doesn't have any, check on the Internet. It will likely still be less expensive than going to a coffee shop.

Old coffee should never be reheated. Although people often say that it is dangerous because there are chemicals in it, that is not true. Throw away coffee that has been sitting around for a while as it will have changed in flavor, and not in a good way. Your coffee may come bitter, acidic, or weak.

Put some money towards a simple coffee grinder. Freshly ground beans can be the difference between a delicious cup of coffee and a so-so cup of coffee. The majority of machines permit adjustments to the grind. There are also coffee machines that come equipped with


migrants in exchange for €6 billion and a promise to fast-track European Union membership talks and visa-free travel for its nationals.

But, one year on, there is a very real possibility the deal could unravel, the chief architect of the deal, Gerald Knaus, head of the European Stability Initiative, told Germany’s daily Deutsche Welle (DW).

Ankara "irrational"

“It would be irrational to shut it down, but we’ve heard a few irrational things from Ankara recently, so it is not impossible that something that would be bad for Turkey in this escalating unacceptable rhetoric might also claim the refugee agreement as a victim”, he said.

The fierce diplomatic row that continues to unfold between Berlin and Ankara over Turkish referendum campaign rallies in Germany has turned the deal into something of a politicalA Pakistani woman came forward accusing her husband of beating her and shaving her head after she refused to dance for him and his friends.

Asma Aziz, of Lahore, posted a video on social media on Tuesday, March 26 showing her visibly bruised face and shaved head. In the video she explained what her husband Mian Faisal allegedly did to her.

"He took my clothes off in front of his servants. The servants held me as he shaved my hair off and burned it. My clothes were bloody. I was bound by a pipe and hung from the fan. He threatened to hang me naked," she said, according to the BBC.

INDIA AND PAKISTAN'S FIGHT OVER KASHMIR: A HISTORY OF VIOLENCE AND INSURGENCY

Aziz said she went to the police “to file


The archive stores a multitude of state documents, manuscripts and other items dating all the way back to the 11th century.

The Russian State Archive of Ancient Documents in Moscow is the country’s primary repository of manuscripts and records dating back to the Middle Ages and beyond, but the story of the archive itself is not short of interest.

The Saeco coffeemaker appears out of place in Yevgeniya Lykova’s office. Centuries-old manuscripts are scattered around chaotically, a vintage typewriter rests on a shabby cupboard. The coffeemaker is one of the few reminders of the modern world in this room full of antiques.

Every morning Lykova, a deputy director of the Russian State Archive of Ancient Documents (RGADA), enters the cream-colored building, originally built in 1886. She joined the archive soon afterfrom django.contrib.auth import get_user_model
from django.db import models
from model_utils.models import TimeStampedModel
from simple_history.models import HistoricalRecords

User = get_user_model()

class UserDemographics(TimeStampedModel):
    """
    A Users Demographics platform related data in support of the Demographics
    IDA and features
    """
    user = models.OneToOneField(User, on_delete=models.CASCADE)
    show_call_to_action = models.BooleanField(default=True)
    history = HistoricalRecords(app='demographics')

    class Meta(object):
        app_label = "demographics"
        verbose_name = "user demographic"
        verbose_name_plural = "user demographic"

    def __str__(self):
        return 'UserDemographics for {}'.format(self.user)


to use when my kind but not "important" neighbor decides to thank me by sending me a letter. 'honored' would be a very strong word to say in that case.
There's humbled too but I think it is, if anything, as strong as honored.

A:

While this might not be the site where this question can serve as a compendium of sorts for all synonyms, the words flattered or delighted are similar to and milder than honored.

Flatter--To please or gratify the vanity of: "What really flatters a man is that you think him worth flattering" (George Bernard Shaw). American Heritage, 5th Ed.
Delight--Extremely pleased (to do something): I'm delighted to hear it! Collins English Dictionary 12th Ed.

A:

Perhaps, pleased works here.
ODO:

pleased
ADJECTIVE
1 Feeling or showing pleasure and satisfaction, especially at an event oranother leap forward for equality.”

Not everybody is happy however, and the loudest of the dissenting voices comes from the Moderator of the Free Church of Scotland, Revered David A Robertson, who stated in an article in the Daily Mail, “Not content with the destruction of the traditional Christian ideas of sexuality and marriage, it appears the SNP are now seeking to destroy the traditional idea of gender. We do not believe that this will lead to the Brave New World envisaged by the proponents of the multi gender doctrine. It is destructive of humanity and will cause chaos in our society. The SNP seem to be working on the unproven and somewhat bizarre notion that children get to choose their own gender and sexuality.”

Rev Robertson is no stranger


In terms of cardiovascular risk profile, patients did not present an excess of baseline coronary risk factors compared to the general population in the same geographical area. Patients with iSSNHL had a higher prevalence of the 807T thrombophilic polymorphism of platelet glycoprotein Ia/IIa. Patients homozygous for this polymorphism are less likely to recover from iSSNHL. Classical cardiovascular risk factors were not related to iSSNHL.for the device. The carrier promoted the offering with a $15 discount on its Unlimited, My Way and My All-in plans--to $65 per month from $80. After 12 consecutive payments, customers could give back their current device, as long as it was in good working order, and upgrade to a new smartphone or tablet. Sprint One Up was available for smartphones on the My All-in plan as well as on tablets in combination with tablet plans starting at just $5 a month.

Sprint's new Framily plan, which some might refer to as a calling circle, provides greater savings for everyone in the group as more people join.

Under Framily, which is now in effect, new Sprint customers pay $55 per month per line for unlimited talk, text and 1 GB


      class: { this.size },
                attrs: { class: 'ui label'}
            },
            this.$slots.default
        );
    }
}

What am I doing wrong -- and, more importantly, how can I do it right?
Thanks.

A:

This should do it.
export default {
  props: ['tag', 'type', 'size', 'color', 'direction'],
  render(createElement) {
    // set the default classes
    let classes = ["ui", "label"]
    //check to see if we have a size arrtibute
    if (this.size)
but we have lots of things planned for this year, and new features and functionality, and new sets and cards, and that kind of thing. So I'm excited to be able to talk about those hopefully before too long. MMORPG.com: So, Chaos Arena is coming back every month? Pete Hines: Yeah, so every month. For now, it will be the same as it was last month, which is that there are a bunch of different scenarios that you can get, which are these broader, overreaching things that affect the game, or you can get a bunch of different lane conditions, and it's different for every game that you play. It's the first time that things like random lane conditions or scenarios have been a part of playing against


new background check proposals.

While LaPierre has not detailed his discussions with Trump this week, he said in a statement that "the NRA opposes any legislation that unfairly infringes upon the rights of law-abiding citizens."

Gun control supporters back bills approved by House Democrats that would expand and improve the background check system. The Republican-run Senate has refused to take up the measures.

Congressional action in the short term is highly unlikely. There are no apparent plans to call Congress into session during its August recess. As of mid-day Thursday, Trump had no meetings scheduled with congressional leaders.

House Speaker Nancy Pelosi, D-Calif., has urged Trump or Senate Republican leader Mitch McConnell, R-Ky., to call Congress back into session immediately, breaking up the August recess to address the gun violence crisis.

Trump andIceland - Land of the whale watchers or whale hunters?

Iceland recently resumed whaling for the first time since 1989. The decision will not only cost the lives of many whales but also affect the reputation of Iceland and its burgoning whale watching industry.


Thursday, April 01, 2010

Remember last week when my most favorite mug ever was broken? Yeah, I’m still a little sad about it.

I realize that to some, a mug is a mug. But not to me. A mug has character. It has a certain feel in your hand, and even on your lips. You must find the right mug for your personality and what you like to drink. So when the blue mug with green frogs (that I originally bought for Husband) bit the dust, I knew replacing it would be a challenge.

I knew the perfect mug was out there. It had to be. It’s almost as if there were a cave with names and numbers crudely written on the wall with the ones who just didn’t measure upphaser will have two notches.

Additionally, the output can be fed back to the input for a more intense effect, creating a resonant effect by emphasizing frequencies between notches. This involves feeding the output of the all-pass filter chain back to the input, as shown here:

The frequency response of an 8-stage phaser with or without feedback is shown. Note that the peaks between the notches are sharper when there's feedback, giving a distinct sound.

A stereo phaser is usually two identical phasers modulated by a quadrature signal; the output of the oscillators for the left and right channels are a quarter-wave out of phase.

Most modern phasers are a part of a digital signal processor, often emulating analog phasers. Phasers are mostly found as plugins for sound editing software,


Wehid Iqbal, director of the Silicon Valley mobile phone shop in Wellington, said: "If it was not so scary it would be laughable".

He was speaking after members of the far-right group Britain First produced a video that highlighted an Islamic symbol on the Silicon Valley shopfront, and claimed the store was sporting the symbol of terrorist group Isis.

The video has been viewed nearly 400,000 times on Facebook, and has been shared around 5,000 times. It comes as Britain First is planning a march in Telford later this month.

The Britain First video, which has been viewed 400,000 times online

Although the symbol in question does appear on the Isis flag, the terrorist group has appropriated the image, which is around 1,500 years old, and used it as part of itsstandard.

Mr Iqbal said the symbol has been used on his business for the past 13 years, before the creation of Isis, and has absolutely nothing to do with the terror group. It is a replica of the seal the prophet Muhammad would use on letters he sent out to foreign dignitaries. It states three words translated as 'God's messenger Muhammad'.

He said: "We have been in the county doing business for nearly 13 years now and that symbol has been used for 13 years so it pre-dates any use by any particular group. That symbol has been around for more than 1,500 years. We are not going to allow Britain First members to hijack it to use it to promote their march."

It is understood that the police and the


Home Office have been monitoring the situation.

Advertising

Mr Iqbal said that the shop has been on the receiving end of threats since the video was posted online.

He said: "We have had real nasty messages come through, people saying they are going to firebomb the place. But we have had some nice messages of support from people in the community too. People coming into the shop and saying it is appalling and it does not represent Christianity or themselves."

The business director said that members of the group had visited the shop twice, and had made the video on the second occasion.

He said: "I have been worried for the safety of staff. The staff themselves were left shaken by the incident."

Advertising

The video shows a Britain First member comparing the symbol on= -151826 + 219775. What is the units digit of j?
9
Suppose -2*f = 3*u - 6 + 2, -3*f = 5*u - 8. Suppose 6 = u*q - q. Suppose -q = 2*c - 3*h - 102, -4*c + 200 = -h. What is the units digit of c?
0
Let x = 12542 - -8814. What is the ten thousands digit of x?
2
Suppose -247 = -k + 2*j - 4*j, 0 = 3*k + 5*j - 746. Suppose 3*t - 4*i - 518 = t, t - 4*i - k = 0. What is the hundreds digit of t?
2
Suppose -14761 = 12*y - 125209. What is the thousands digit of y?
9
Let n(a) = 446*a + 288. What is the thousands digit of n(14)?
6
Let i(w) = 153*w. Let v(m) =


hundreds digit of c(4)?
6
Suppose 74 = 6*m + 50. Let n(t) = -6*t + 3 + t**3 + 2 + 4*t + 5*t. What is the units digit of n(m)?
1
Let x be 4/(-14) + (-1776)/(-42). Let t = x - 57. What is the tens digit of t/10 - 276/(-8)?
3
Let f(y) = -y**3 - 33*y**2 + 36*y + 74. Let k be f(-34). What is the units digit of 2700/72*((-8)/k)/(-2)?
5
Let k = 3 + -16. Let p = k - -56. What is the units digit of p/((-1)/(-6 - -5))?
3
Suppose 2*l = -4*p + 636, -2*l - 149 = 5*p - 6*p. Let m = 737 + p. What is the hundreds digit of m?
8
Let s(v) = -8*v**2 + v - 35. Let p(h) = -4*h**2 - 18.Let n(j) = 5*p(j) - 3*s(j). Let d be n(15). Suppose 26*m - d = 20*m. What is the tens digit of m?
4
Suppose -n + 6*n + 5*f - 40 = 0, -5*n + 16 = -f. Suppose 4*s = -4*y + 640, n*s - 182 - 132 = -2*y. Suppose -13*t = -y - 539. What is the tens digit of t?
5
Let k = -20276 + 33809. What is the hundreds digit of k?
5
Let v(l) = -4*l**3 + 31*l**2 - 12*l + 21. Let u(g) = 3*g**3 - 29*g**2 + 11*g - 22. Let a(n) = -3*u(n) - 2*v(n). What is the tens digit of a(8)?
4
Suppose -47*o + 72 = -23*o. What is the tens digit of ((-11178)/(-63))/(o/28)?
5
Let x(b) = 353*b**2 + 113*b - 514. What is


# /* Copyright (C) 2001
#  * Housemarque Oy
#  * http://www.housemarque.com
#  *
#  * Distributed under the Boost Software License, Version 1.0. (See
#  * accompanying file LICENSE_1_0.txt or copy at
#  * http://www.boost.org/LICENSE_1_0.txt)
#  */
#
# /* Revised by Paul Mensonides (2002) */
#
# /* See http://www.boost.org for most recent version. */
#
# ifndef BOOST_PREPROCESSOR_LIST_FOLD_RIGHT_HPP
# define BOOST_PREPROCESSOR_LIST_FOLD_RIGHT_HPP
#
# include <boost/preprocessor/cat.hpp>
# include <boost/preprocessor/control/while.hpp>
# include <boost/preprocessor/debug/error.hpp>
# include <boost/preprocessor/detail/auto_rec.hpp>
#
# if 0
#    define BOOST_PP_LIST_FOLD_RIGHT(op, state, list)
# endif
#
# define BOOST_PP_LIST_FOLD_RIGHT BOOST_PP_CAT(BOOST_PP_LIST_FOLD_RIGHT_, BOOST_PP_AUTO_REC(BOOST_PP_WHILE_P, 256))
#
# define BOOST_PP_LIST_FOLD_RIGHT_257(o, s, l) BOOST_PP_ERROR(0x0004)
#
# define BOOST_PP_LIST_FOLD_RIGHT_D(d, o, s, l) BOOST_PP_LIST_FOLD_RIGHT_ ## d(o, s, l)
# define BOOST_PP_LIST_FOLD_RIGHT_2ND BOOST_PP_LIST_FOLD_RIGHT
# define BOOST_PP_LIST_FOLD_RIGHT_2ND_D BOOST_PP_LIST_FOLD_RIGHT_D
#
# if BOOST_PP_CONFIG_FLAGS() & BOOST_PP_CONFIG_EDG()
#    include <boost/preprocessor/list/detail/edg/fold_right.hpp>
# else
#    include <boost/preprocessor/list/detail/fold_right.hpp>
# endif
#
# endif
are three points of $S$ of the form
  $(x,y)$, $(x,z)$ and $(y,z)\\ $).

The constant $1/2$ cannot be lowered, as the example of the subset $S^* :=(0,1/2)\times(1/2,1)\cup(1/2,1)\times(0,1/2)$ shows (for any three points $x,y,z$ in $[0,1]$, at least 2 of them are both either smaller or larger than $1/2$, so the corresponding pair is not in $S^*$.

A:

Let $S(x)=\{y\mid(x,y)\in S\}$ and $S^{-1}(y)=\{x\mid(x,y)\in S\}$, and let $\lambda_n$ denote the Lebesgue measure on $[0,1]^n$. We have
$$\begin{align*}
\int_S(\lambda_1S(x)+\lambda_1S^{-1}(y))\,dx\,dy
&=\int_S\lambda_1S(x)\,dx\,dy+\int_S\lambda_1S^{-1}(y)\,dx\,dy\\
&=\int(\lambda_1S(x))^2\,dx+\int(\lambda_1S^{-1}(y))^2\,dy\\
&\ge\left(\int\lambda_1S(x)\,dx\right)^2+\left(\int\lambda_1S^{-1}(y)\,dy\right)^2\\
&=2(\lambda_2S)^2>\lambda_2S=\int_S1\,dx\,dy,
\end{align*}$$
hence there exists $(x,z)\in S$ such that $\lambda_1S(x)+\lambda_1S^{-1}(z)>1$. This implies $S(x)\cap S^{-1}(z)\ne\varnothing$, i.e., there exists $y$ such that $(x,y),(y,z)\in S$.