the dose of APC that we used *in vivo* is equivalent to a dose of about 130 mg/kg/day in human, according to dose translation from animal to human^[@CR48]^.

At present, nothing can be said on the exact molecular mechanism(s) of APC effects. One explanation could be that, the inhibition of thyroid functions by the test compound could be the result of decrease in T~4~ synthesis and/or secretion at the glandular level and by the reduction of T~4~ to T~3~ conversion, an important process of T~3~ formation. Another key mechanism is that, APC might have ameliorated the thyrotoxicosis by regulating the expression of TPO and TSHR proteins.

In conclusion, the isolated compound allylpyrocatechol exhibited its potential in minimizing the pathophysiology of T~4~-induced thyrotoxicosis in rats with additional hepatoprotective effects. Possibly this anti-thyroidstructure of the isolated APC (Fig. [1](#Fig1){ref-type="fig"}) was elucidated using different spectral analyses such as IR, NMR and GC/MS.

Spectral data analyses {#Sec19}
----------------------

Gas chromatography mass spectroscopy (GC-MS) analysis of the isolated compound was carried out on JEOL GCMATE II system from Agilent Technologies, USA. The HP-5 column used in GC was of 30 m long and 0.25 mm diameter. Purity of APC was determined by HPLC using a Shimadzu LC-20AT system equipped with Shimadzu diode array detector. For chromatographic separation, C18 column (4.6 mm × 250 mm, and particle size 5 µm), from Agilent Technologies Inc., Santa Clara, CA, USA was employed. The ^**1**^H and ^13^C NMR spectra were recorded on Bruker NMR spectrometer at 500 and 125 MHz respectively in CDCl~3~ as solvent and tetramethylsilane (TMS) as the internal standard. Chemical shifts are expressed in δ (ppm).

###


Q:

Amazon EC2 Sql Performance

I'm considering using Amazon's EC2 with a windows instance & SQL. I've seen some criticism of the perf of the SQL instances here. I'm wondering if any SOers have and first  hand experience and can comment on the performance.

A:

I've just fired up a 32bit Server 2003 m1 small instance with SQL 2005 Express on and had a quick play. Was just using the supplied machine disk, not an attached volume. After reading the article linked to in your post I was expecting performance to be horrific. It wasn't great, but wasn't bad either.
My 'tests' were rather simple. Created a table with an identity column, a few text (varchar) colomns and a few more integer foreign key columns with relationships to some basic lookups.
ItRequirements would be transparency so that the cashier can see what you’re buying, and ability to hold friable stuffs such as flour or sugar.

A:

Some stores (for example the co-op in Northfield, MN) allow you to bring your own reusable plastic or glass containers, but you need to weigh your containers before you fill them. The co-op in Bozeman, MT provides clean glass jars for bulk liquids, and when you have finished with them you can bring them back to the store to be cleaned and set out for other customers.
So yes, there are sustainable alternatives, but you will need to check with your local store to be sure they will accept your containers.

A:

For produce, you can make or buy mesh bags for use just as you reuse the


grocery bags.  We made some but I would think that bags made to hang items for drying (e.g. while camping) would work well.  For powders you could use glass jars if your grocery has scales that can be tared.  You could also use a stronger storage bag like Ziploc that is more likely to stand up to reuse.

       "'Paul, Joe@Dynegy'"
<joe.paul@dynegy>, "'Pocta,
                                         Mark@ORA'" <rmp@cpuc.ca.gov>,
"'Scott, Susan@TW'"
                                         <sscott3@enron.com>, "'Worster,
Gerard@TXU'"


duration of clinical action. However, succinylcholine elicits muscle membrane xe2x80x9cdepolarizationxe2x80x9d which makes this compound less desirable. Furthermore, it may produce serious side effects.
Several other so called xe2x80x9cnon-depolarizingxe2x80x9d muscle relaxants are known and used in anesthesia and surgery. These chemically diverse non-depolarizing muscle relaxants include, among others: tubocurarine, pancuronium, atracurium, cisatracurium, vecuronium, mivacurium and rocuronium. The common structural feature of these compounds is one or usually two quaternary nitrogen atoms. They are all clinically acceptable because they produce only mild or no side effects. However, their onset of action is too slow and their duration of action is too long. Thus, these agents, without exception, fall short of the requirements of an xe2x80x9cidealxe2x80x9d surgical muscle relaxant.
Hungarian Patent No. 142,597 issued on Sep. 15, 1955, discloses a series of compounds  peaches
        5           pears

We'll just be working with the user with userid = '5'. A couple things to note here: not all the entries in currentfruits are in fruitsinfo and not all the entries in userfavorites are in currentfruits.
When the users usually access the site with no favorites saved, they just see currentfruits left joined with fruitsinfo and ordered by price, like so:
   id     |  price   |   months left in season  | color  | rating
blueberries   2.20


of tumor cells by promoting their migration, invasion, or proliferation (reviewed in Gregory and Houghton, [@B11]; Dumitru et al., [@B8]). Thus, it is not surprising that very recent studies reported an association of high numbers of tumor-infiltrating neutrophils with advanced disease and poor clinical outcome in patients with different types of cancer, such as renal cancer (Donskov and von der Maase, [@B6]; Jensen et al., [@B16]), hepatocellular cancer (Kuang et al., [@B18]), non-small-cell lung carcinoma (NSCLC; Ilie et al., [@B13]), or melanoma (Jensen et al., [@B17]). Recently, we demonstrated that high neutrophilic infiltration of the tumor tissue associated with high tumor (T) stage and poor survival in head and neck (orohypopharynx) cancer patients with advanced disease (Trellakis et al., [@B25]). Furthermore, our *in vitro* studies indicated a direct     31.5

Cell lines, conditioned supernatants, and siRNA transfections
-------------------------------------------------------------

The human hypopharyngeal carcinoma cell line FaDu was obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). The cells were cultured and maintained in RPMI-1640 (Invitrogen, Karlsruhe, Germany) supplemented with 10% fetal calf serum (Biochrom, Berlin, Germany), 100 units/mL penicillin, and 100 (g/mL streptomycin (PAA-Laboratories GmbH, Coelbe, Germany). To obtain tumor-conditioned supernatants (FaDu SN), we incubated 2 × 10^6^ cells/mL for 24 h at 37°C in RPMI-1640 supplemented as above. The resulting supernatant was centrifuged to remove cellular debris and stored at −20°C.

To knock-down CORTACTIN, we transfected FaDu cells with 25 nM validated CORTACTIN siRNA or 25 nM AllStars Negative Control (mock) siRNA (both from Qiagen, Hilden, Germany) using the NEON™ transfection system (Invitrogen, Karlsruhe, Germany).

Migration assay
---------------

Migration of FaDu cells was assessed with


Roche Diagnostics (Mannheim, Germany).

Immunohistochemistry and immunofluorescence
-------------------------------------------

Frozen sections of tumor or healthy epithelial tissue were fixed with BD Cytofix/Cytoperm and incubated with primary antibodies overnight at 4°C. Secondary (and tertiary reactions, for colorimetric immunohistochemistry) were performed for 30 min each at room temperature. Nuclei were counterstained using Hematoxylin -- for immunohistochemistry (Thermo Scientific, Karlsruhe, Germany) or DRAQ5 -- for immunofluorescence (eBioscience, San Diego, CA, USA). Samples were finally mounted in Kaisers glycerol gelatine (Merck, Darmstadt, Germany) or in Fluoprep (bioMerieux, Marcy l'Etoile, France) and analyzed with a Zeiss Axioskop 2 microscope (Zeiss, Jena, Germany).

For TMAs, immunohistochemical staining was performed with an automated staining device (Dako Autostainer; DakoCytomation, Hamburg, Germany) using rabbit anti-human CORTACTIN antibodies. Secondary and tertiary immunoreactions were performed with commercially available anti-rabbit IgG detection kit (En-Vision; DakoCytomation, Hamburg,was performed with the log-rank test. Graphical depiction of **(B)** T-stage, **(C)** N-stage, and **(D)** laterality of lymph node metastasis in patients with low CORTACTIN versus high CORTACTIN expression. Statistical analysis was performed with the χ^2^ test (*p* = 0.027 for T2 versus T4; *p* = 0.008 for T1--2 versus T3--4; *p* = 0.005 for N2a versus N2c-3; *p* = 0.016 for N unilateral versus bilateral). The absolute patient numbers are indicated above each bar of the graphs.](fimmu-04-00033-g002){#F2}

CORTACTIN and neutrophilic infiltration in orohypopharynx carcinoma
-------------------------------------------------------------------

Accumulating evidence indicates a critical role of tumor-infiltrating immune cells in the progression of different types of solid cancers. Recently, we demonstrated that high numbers of tumor-infiltrating neutrophils (CD66b^high^) associated with higher T-stage and poor survival in orohypopharynx carcinoma patients with advanced disease (Trellakis et al., [@B25]). Evaluation of the entire cohort of


then determined the migratory potential of the tumor cells in the presence or absence of factors released by "primed" neutrophils. The results showed that mock-transfected FaDu cells displayed accelerated migration in response to neutrophil stimulation, as indicated by enhanced closure of the detection zone ("gap"; Figure [7](#F7){ref-type="fig"}C). In contrast, this effect of neutrophil stimulation was abolished in CORTACTIN knock-down FaDu cells (Figure [7](#F7){ref-type="fig"}C). These findings indicate that, consistent with the results presented in Figure [4](#F4){ref-type="fig"}, high levels of tumoral CORTACTIN are required for neutrophil-induced tumoral migration and progression.

![**Neutrophils promote the migration of FaDu cells via CORTACTIN**. **(A)** FaDu cells in which CORTACTIN had been knocked-down by siRNA were stimulated with FaDu/neutrophil SN and migration was assessed 48 h later. **(B)** Efficiency of CORTACTIN knock-down was determined by flow cytometricFAK (focal adhesion kinase) and paxillin via src, as well as p38-MAPK via Rho-GTPase (Strell et al., [@B24]). In hepatocellular carcinoma, neutrophils were activated by tumor-derived hyaluronan binding to TLR4 on their surface and promoted tumor cell motility (Wu et al., [@B27]). Notably, both of the above-mentioned studies indicated that the pro-migratory effects of neutrophils are mediated via direct cell-to-cell contact. In our system, neutrophils activated CORTACTIN and enhanced tumor migration via release of soluble factors. Thus, besides supporting the association of CORTACTIN and neutrophils with increased metastasis in cancer patients, these findings unravel a novel mechanism of neutrophil-mediated tumor migration and progression. We certainly do not exclude that, other infiltrating immune cells (in particular macrophages) enhance the aggressiveness of orohypopharynx carcinoma *in vivo*. However, extensive work is


3, 8*p + 16 = 4*p + 3*z. Let y be 2/p + (2 - 6 - -150). Let o be y/32*2/3. What is the greatest common divisor of o and 3?
3
Let l be (-100)/(141/94 + (-22)/12). Calculate the greatest common divisor of 180 and l.
60
Let t be (-20)/5*681/(-12). Let v be t + (4 - -2) + 1. What is the highest common factor of 26 and v?
26
Let w = -49 - -55. Suppose -w*j = -j + 9460. Let u be j/(-22) - (1 + 1 + 0). What is the greatest common factor of 42 and u?
42
Let k(g) = 31*g + 1. Let v be k(6). Let a = 11776 - 11759. What is the highest common factor of a and v?
17
Let j = 8369in today’s edition — the green dot represents where I’m located, the yellow circle indicates the strongest concentration of overall worst air quality — right where I am — and the red marks indicate, obviously, the area wide fires, which are ongoing tonight:

Map, Todd Trumbull, Chronicle: original version here, along with captivating photographs.

And, more photographs from The San Francisco Chronicle, with this sad article about today’s loss of life by a heroic firefighter in the San Diego area — obviously, these are no ordinary fires, and all combined are making for a huge inferno in Southern California, and not under control, even now.


The radiographic detection of acute pulmonary oedema. A comparison of radiographic appearances, densitometry and lung water in dogs.
We have induced acute pulmonary oedema in upright anaesthetized dogs by increasing pulmonary microvascular permeability or by extracellular fluid volume overload in order to determine the sensitivity and specificity of the radiograph to the presence of abnormal lung water. Radiographs were taken before and after development of oedema. At the end of the experiment we removed the inflated lungs and froze them in liquid nitrogen and subsequently examined them macroscopically in the frozen state. The extravascular water/dry lung weight ratio was measured gravimetrically on seven portions of each lung. Finally without the base-line films for comparison. We directly measured the change in opacity of the films with a radiographic densitometer. Whenproducts and solutions in this area. Besides customized orders are also available. What's more you will enjoy our excellent services. In one word your satisfaction is guaranteed. Welcome to visit our company! For more information you should come to our website.If any further inquiries please feel free to contact us.


keep an eye on her, and is best friends with Hale, his Light Fae detective partner. In the Season 1 finale, he involuntarily sacrifices his love for Bo when he offers his wolf to the Norn in return for her giving Bo the strength to defeat her murderous and maniacal mother, Aife; but the Norn – who demanded his wolf the first time he asked a favor from her in "Brother Fae of the Wolves" – realizes that his wolf is no longer what he values most and takes his love for Bo and his ability to love anyone else again instead; leaving him with the memory of their relationship but unable to feel his passion for her. He makes efforts to remain friends with Bo, which iseagle, and can possess and control its victims. Its source of food is anger and rage, and can only be killed with the venom of a Nāga. When the Blood King (Trick) writes the truce and Blood Laws that ended the Great War between Light and Dark, the Garudas dwindle as they starve to death until only one is left, remaining dormant for eons. When Trick uses his blood powers to stop Aife from hurting and killing Bo, it revives the Garuda, which then comes in search of Trick to force him into using his blood to repeal the Laws and reignite the war between Light and Dark. He is killed by Bo with Lachlan's venom. (Season 2)
 Aaron Ashmore as Nate: Kenzi's boyfriend. Kenzi and Nate used


articulate their experiences (Huberman & Miles, [@cit0023]; Padgett, [@cit0033]). There was no strict order of questioning and occasional prompts were used, if necessary, to facilitate the flow of the narration. Summarisation was used to provide the interviewees with feedback about what they seemed to be expressing and to check understanding. Each interview lasted about two hours and all were audio-taped and subsequently transcribed from Cantonese to English.

Our analysis of the interview transcripts was carried out in steps as follows (Burr, [@cit0005]; Huberman & Miles, [@cit0023]). First, we identified key terms and themes. Second, we examined these terms and themes with reference to the global organising features of the transcripts: major events, the protagonists and their relationships, and the network of terms around which the arguments were articulated. Atby educational institutions, our research suggests that school reform in Hong Kong is necessary. According to the TOS interviewees who did poorly in their studies, most teachers appeared to be insensitive to the learning needs of disadvantaged students and were unwilling to help them improve. There are two remedies to this situation: resources and training for teachers, or the introduction of professionals with expertise into the school system (e.g. social workers from community-based youth centres). For instance, schools could develop career resources aimed at young people from low-income households and ensure that the teacher role encompasses a focus on future goals while also making the expertise of career development professionals available on a consultancy basis (Cauce et al., [@cit0007]). At the school policy level, targeting school stability, encouraging


are possible through the creation of support for disadvantaged youths and a simultaneous effort to improve the basic conditions of family life.

Furthermore, our study pinpoints the vital importance of targeted vocational and employment support services for economically disadvantaged young people. Our interviews with the TOD group reveal an essential element of these services -- the on-the-job training approach inspired by learning by doing and work-based learning (Polesel, [@cit0035]). The close link with local companies that on-the-job training provides also makes it possible to plan a learning experience that is more closely related to the actual demands of the working world (Creed et al., [@cit0012]). Another element of success in vocational and employment support services is the focus on emotional dynamics and relationships between youth participants and trainers orof the substrate tyrosine, the steady-state levels of norepinephrine remained unaltered in various regions of brain except in cerebellum. Futhermore, neonatal hyperthyroidism significantly increased the levels of midbrain tryptophan and tryptophan hydroxylase activity but produced no change in 5-hydroxytryptamine levels of several discrete brain regions, except hypothalamus and cerebellum where its concentration was slightly decreased. However, the 5-hydroxyindoleacetic acid levels were enhanced in hypothalamus, ponsmedulla, midbrain, striatum and hippocampus. The elevated levels of 5-hydroxyindoleacetic acid did not seem to be due to increased intraneuronal deamination of 5-hydroxytryptamine since monoamine oxidase activity was not affected in cerebral cortex and midbrain of hyperthyroid rats. The data demonstrate that hyperthyroidism significantly increased the synthesis as well as the utilization of catecholamines and 5-hydroxytryptamine in maturing brain. Since the mature brain is


put:
Object.__proto__ == Function means that Object itself is a function, because it's the constructor. It doesn't mean that objects that inherits from Object will inherit Function. An object inherits a constructor's .prototype, not its .__proto__
In other words
function Car (){}
inst = new Car ();
// inst inherits from Car.prototype
// inst.__proto__ == Car.prototype;
// Car inherits from Function.prototype because it is a function
// Car.__proto__ == Function.prototype;

But that doesn't mean that inst inherits from Function.prototype, you can't call apply and call on it.
// This means that Everything that inherits from function will
console.log(`Function.prototype`) === function Empty() {}

Another twist
// This means that the constructor function (Object)
// inherits from `Function.prototype` That is, you can use call and apply,
// And at a lower language level, you can use () and new on it.
Object instanceof Function //true

// It doesn't mean that instances created from Object inherit
// from Function.prototype (can't use call/apply)
(new Object()) instanceOf Function ? // false
(new Object()).apply === undefined ? // true

// This means that functions themselves are objects, everything is an object
// They have properties like hasOwnProperty and isPrototypeOf
// Not that everything that inherits from Object.prototype will also inherit
// From Function.prototype
Function instanceof Object // of course true


meshes can limit the cell\'s tissue-specific remodeling of their surroundings and the secretion of the desired ECM that can be crucial in the development of functional tissue.

Furthermore, the fibers are randomly distributed as is typical with electrospinning and thus topographically induced cell behavioral cues such as alignment were not observed. Electrospinning oriented fibers can be achieved through a number of techniques such as using a rotating mandrel collector, conductive electrodes separated by an insulating gap, a patterned collector, and near-field electrospinning.^[@B15]^ The ECM in most tissues has an anisotropic architecture, thus the fabrication of aligned fibers is key to mimicking the native structure and has a significant effect on cell behavior and tissue regeneration.^[@B15],[@B18]^

The combination of 3D printing and electrospinning utilizing a low-density mesh to facilitate cell migrationSEM ([Fig. 5c](#f5){ref-type="fig"}). Cell--fiber orientation analysis demonstrates highly aligned cell bodies within the pores and a second distribution population (∼40°) corresponding to the original attachment points of the electrospun fibers and now angled as a branching point for the main fiber--cell bundle ([Fig. 6](#f6){ref-type="fig"}). Clusters of cells are observed in the individual bundles and multiple cell--nanofibers bundles are bridging between the printed fibers. Cell morphology is considerably more elongated than the cells attached on the printed microfibers. This behavior is unique to the dual-scale scaffold with the 3D-printed only scaffold showing typical cell--microfiber interactions with cells spreading across the printed fibers. The cells can also remodel the electrospun fibers as can be observed in the difference in the mesh density and electrospun fibers visible before and after cell


seeding ([Figs. 2](#f2){ref-type="fig"} and [5](#f5){ref-type="fig"}). The cells seem to physically pull and move the nanofibers that results in the change of cell morphology observed between the nanofibers and the printed microfibers. The electrospun nanofibers that were distributed across the pore are now, after cell seeding, arranged into fiber--cell bundles in the middle of the pore that branches off and connects with the printed fiber when in proximity to the microfiber ([Fig. 6a](#f6){ref-type="fig"}). A higher density mesh would resist the deformation by the cells resulting in a different cell morphology. Subsequently, further investigation is required to determine how altering the density of the suspended mesh between the two printed fibers can affect the mechanical properties of the mesh and thus how the cells sense the surface resulting in changes= -1505 + 16391. Does 157 divide q?
False
Suppose 2*t + 3268 = 4*n, 5*n - 4063 = -t - 2*t. Let z be ((-1)/(-1))/(17/8483). Suppose -z = -6*k + n. Is k a multiple of 45?
False
Suppose -2*a - a + 84 = 0. Let j = -26 + a. Suppose 0 = -j*l + 217 - 71. Is l a multiple of 19?
False
Suppose 0 = -5*f + 1627 + 628. Let t be 5612/10 - (9 + (-9 - 3/(-15))). Suppose -t = -4*g + f. Is 11 a factor of g?
True
Let c = -3247 + 4760. Is c a multiple of 89?
True
Let p(x) = -21*x**3 - 2*x**2 - x + 2. Suppose 2*i + 2*k = -10, 2*i = 5*k - k - 22. Let w be


= -4*h + 1198. Is h a multiple of 31?
False
Let m(i) = 6*i**2 + 82*i - 24. Is 7 a factor of m(-36)?
False
Suppose 53*c + 642350 = 198*c. Is c a multiple of 7?
False
Suppose x - 2*x = -3*a - 469, 0 = 5*x + 2*a - 2430. Let r = -8 + x. Is r a multiple of 17?
True
Does 29 divide (28/(-56))/(1/(-13630 + -4))?
False
Let r(a) = -35*a - 122. Let n be r(-4). Suppose 0 = n*o + 649 - 8209. Does 35 divide o?
True
Let h = 114 - 112. Suppose h*z - 5*t = 129, 0 = -5*z - 3*t - 0*t + 369. Is 5 a factor of (10/(-6))/((-24)/z)?
True
Let f(n) = -3244*n + 10836. Is 75 a factor of f(-6)?
True
Let k be 1/(-8) - (-9   slopeTangent[(slopeTangent >= 5) & (slopeTangent < 20)] = -20
        slopeTangent[(slopeTangent >= 20) & (slopeTangent < 40)] = -30
        slopeTangent[(slopeTangent >= 40)] = -40
        slopeTangent[(slopeTangent == -10)] = 10
        slopeTangent[(slopeTangent == -20)] = 20
        slopeTangent[(slopeTangent == -30)] = 30
        slopeTangent[(slopeTangent == -40)] = 40
        aspect[(aspect >= -1) & (aspect <= 22.5)] = 1
        aspect[(aspect > 22.5) & (aspect <= 67.5)] = 2
        aspect[(aspect


becomes all but impossible.

The Difference Between a Partisan and an Ideologue

There can be no meaningful dialogue premised upon shared values if both sides only apply those values when it lets them score points. The class of moderately intelligent politically aware people are those most affected by this trend. They have become partisan ideologues.

An ideologue is at least consistent in his belief in specific policies. A partisan openly supports his gang above all else. But a partisan ideologue is worse than both. He is a Machiavellian creature: a supporter of “ends justify the means” approaches to pushing an agenda. The gang must be defended that the agenda might be defended, even when the gang violates core tenets of the agenda. Partisan ideologues are dishonest by nature. Worse still, they     formatSelectionTooBig: function (limit) { return "Ви можете вибрати лише " + character(limit, "елемент"); },
        formatLoadMore: function (pageNumber) { return "Завантаження даних…"; },
        formatSearching: function () { return "Пошук…"; }
    };

    $.extend($.fn.select2.defaults, $.fn.select2.locales['uk']);

    function character (n, word) {
        return n + " " + word + (n%10 < 5 && n%10 > 0 && (n%100 < 5 || n%100 > 19) ? n%10 > 1 ? "и" : "" : "ів");
    }
})(jQuery);


Q:

Typescript Tagged Unions - Can the compiler warn you about missed branch cases?

I'm new to TypeScript.  I've got the following code:
type Circle = { kind: "circle" }
type Rectangle = { kind: "rectangle" }
type Triangle = { kind: "triangle" }
type Shape = Circle | Rectangle | Triangle

function numberOfSides(shape: Shape) {
    switch (shape.kind) {
        case "circle": return 0;
    }
}

Currently this compiles fine.  Is there any configuration or option so the compiler can warn me that I'm missing cases in my switch statement?

A:

Yes, you just need two things - 1. turn on strictNullChecks or noImplicitReturns.  2. Mark numberOfSides' return type as Number.  At that point the compiler will catch that you are not dealingand two trade exceptions; one for $5.9 million and the other for $2.6 million. The only real hit to the Knicks is the fact that Shumpert has potential to be a very good role player in the future.

It has been said that Phil Jackson wanted to change the culture in the locker room and wanted to get rid of J.R. Smith.

The Knicks are bad and will most likely tank the rest of the season. With their lost on Monday night they tied a franchise record with 12 straight losses and they are now the worst team in the league at 5-32.


21. The gate pad upper electrode 28 is connected to the gate pad lower electrode 26 that is exposed through the third contact hole 27. The data pad upper electrode 34 is connected to the data lower electrode 32 that is exposed through the fourth contact hole 33. The common pad upper electrode 40 is connected to the common pad lower electrode 38 that is exposed through the fifth contact hole 39.
Herein, the material of the transparent conductive film is ITO (indium tin oxide).
In this way, the related art horizontal electric field applying type thin film transistor substrate and the fabricating method thereof reduces the number of processes to four mask processes, thereby reducing the manufacturing cost proportionally thereto.
However, the common electrode 18 formed in the pixel areais dominated by the gate-seat drag. This is due to the fact that the gate-seat drag is proportional to the square of the flow bore diameter, while the stem-packing drag is directly proportional to the stem diameter. The challenge in designing gate valves with relatively small flow bores, for example, less than about an inch in diameter, is that as the diameters of the flow bore and the stem are scaled down, the drop in the gate-seat drag is much greater than the drop in the stem-packing drag. Eventually, the stem-packing drag begins to dominate the required opening force. This sets a lower limit on the stem diameter if a desired opening force is to be maintained. Consequently, the overall dimensions for small bore gate valves are often


to normal function.

Perfusion Imaging {#s2}
=================

Various methods of functional neuroimaging, that is, using neuroimaging methodologies to understand human brain function, exist. Perfusion is one measure used as a surrogate for neuronal activity, on the basis that the more a region of brain is active, the more blood supply that area will require and the higher will be the regional blood flow in that area, which can be mapped with perfusion imaging using various modalities. One such modality is positron emission topography (PET), which can be used to assess perfusion if used along with a radioisotope of labeled water ($\text{H}_{2}^{15}$O). The first PET study using blood flow measurement in the premonitory phase of migraine was conducted in 2014 by Maniyar et al. ([@B31]). The authors used this imaging methodology towith nausea during the premonitory phase relative to those without ([@B34]).

A more recent study utilized perfusion MRI, using arterial spin labeling (ASL), to evaluate brain blood flow changes during the premonitory phase ([@B35]). This study again used nitroglycerin-triggered migraine attacks, because of the logistical issues with repeatedly and reliably capturing spontaneous premonitory symptoms. The authors studied premonitory symptoms in 25 subjects and compared the premonitory scans following nitroglycerin with scans obtained at the same time following placebo in 21 subjects to correct for any possible nitroglycerin-induced changes on cerebral blood flow. Similar areas of increased blood flow (and therefore the suggestion of increased neuronal activity) were identified as the Maniyar et al. study ([@B31]), including the hypothalamus, thalamus, basal ganglia, and limbic cortex, during the premonitory phase, supporting


and 31 healthy controls during different parts of the migraine attack ([@B40]). There was an increase in pain ratings in response to nociceptive stimulation in the lead-up to the next migraine attack, and then these ratings decreased immediately prior to pain. Imaging responses in the spinal trigeminal nuclei dramatically increased in the 24 h prior to pain onset in response to noxious stimulation, with reduced functional connectivity between this region and the rostral ventral medulla. This study therefore suggests a pre-headache sensitivity to pain, or reduced threshold to pain, during the migraine attack (and therefore a susceptibility to exogenous triggers) and the subsequent implication of altered or dysfunctional endogenous pain modulation within the pain network in the brain during the migraine attack or cycle, which may be responsiblefor the sensation of pain felt following premonitory symptoms. The same authors have also recently demonstrated possible structural changes in similar brain areas (dorsolateral pons, periaqueductal gray, and spinal trigeminal nuclei) within 24 h of a migraine attack using mean diffusivity and fractional anisotropy ([@B41]).

We have recently presented our resting-state fMRI results looking at seed-based functional connectivity with the BOLD contrast, in nitroglycerin-triggered premonitory symptoms relative to placebo, and shown increased thalamocortical connectivity and functional uncoupling between the pons and the limbic lobe in the premonitory phase, with increased functional coupling between the pons and spinal trigeminal nuclei during migraine headache, thus suggesting changing alterations in subcortical and brainstem networks in the premonitory phase ([@B42]).

The imaging studies of the premonitory phase are summarized in [Table 1](#T1){ref-type="table"}.

######

Comparison of


other ([@B53]) and, as discussed in this manuscript, involve more global cortical and subcortical brain dysfunction.

Conclusions {#s7}
===========

This review has summarized the neuroimaging literature to date in the premonitory phase, or period leading up to pain, in migraine. The studies have consistently provided evidence for early brainstem involvement, as well as alluded to oscillatory brainstem, hypothalamic, and limbic networks prior to the onset of pain, with alterations in functional coupling between these regions and between pain modulatory regions such as the rostral ventral medulla and periaqueductal gray. Although the brain areas between pre-headache and during headache are similar, it is clear that thresholds may have a part to play in whether pain is perceived or not, despite similar neuroimaging findings in both the premonitory and headache phases of theStreet” crowd — besides the smell of patchouli — is how liberal protesters must claim their every gathering is historic and heroic.

They chant: “The world is watching!” “This is how democracy looks!” “We are the ones we’ve been waiting for!”

At the risk of acknowledging that I am, in fact, “watching,” this is most definitely not how democracy looks.

Sally Kohn, a self-identified “community organizer,” praised the Wall Street loiterers on CNN’s website, comparing the protest to the Boston Tea Party, which she claimed, “helped spark the American Revolution,” adding, “and yes, that protest ultimately turned very violent.”

First of all, the Boston Tea Party was nothing like tattooed, body–pierced, sunken-chested 19-year-olds getting in fights with the police for fun. Paul Revere’s nighttime raid was intended exclusively to protest a new


A.applyOnTheRight(H);             // A = A * H
  * A.applyOnTheLeft(H);              // A = H * A
  * A.applyOnTheRight(H.adjoint());   // A = A * H^*
  * A.applyOnTheLeft(H.adjoint());    // A = H^* * A
  * MatrixXd Q = H;                   // conversion to a dense matrix
  * \endcode
  * In addition to the adjoint, you can also apply the inverse (=adjoint), the transpose, and the conjugate operators.
  *
  * See the documentation for HouseholderSequence(const VectorsType&, constCoeffsType&) for an example.
  *
  * \sa MatrixBase::applyOnTheLeft(), MatrixBase::applyOnTheRight()
  */

namespace internal {

template<typename VectorsType, typename CoeffsType, int Side>
struct traits<HouseholderSequence<VectorsType,CoeffsType,Side> >
{
  typedef typename VectorsType::Scalar Scalar;
  typedef typename VectorsType::Index Index;
  typedef typename VectorsType::StorageKind StorageKind;
  enum {
    RowsAtCompileTime = Side==OnTheLeft ? traits<VectorsType>::RowsAtCompileTime
                                        : traits<VectorsType>::ColsAtCompileTime,
    ColsAtCompileTime = RowsAtCompileTime,
    MaxRowsAtCompileTime = Side==OnTheLeft ? traits<VectorsType>::MaxRowsAtCompileTime


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Enhance your building's kitchenthis produces uncountably many distinct subgroups of the countable group $\mathbb{Q}$.

A:

One example is the group consisting of all finite subsets of $\mathbb N$, with the group operation being symmetric difference. The group is countably infinite, but for each finite or infinite $A\subseteq \mathbb N$ there's a subgroup consisting of the finite subsets of $A$.

A:

There is another one: $F_\infty$, the free group on countably many letters $x_1,x_2, \ldots$.
It is countable because each of its elements is a finite string of symbols from a countable alphabet. At the same time, for every subset $A\subset \mathbb{N}$, there is a subgroup $H_A$ generated by the set $\{x_i | i \in A\}$. These subgroups are distinct, so we get uncountably many of them.
Also, $F_\infty$ embeds into $F_2$, so we can get these uncountably


Q:

Detect autofilter on Excel Tables

Below line detects if there are active AutoFilter in a sheet.
Debug.Print Sheet1.AutoFilterMode

This returns True if there are active filters in Sheet1, False otherwise.
My problem is, this doesn't detect AutoFilter on Tables.
Is there a way to detect AutoFilterMode on Tables, a property I might have missed?

A:

activesheet.listobjects(1).showautofilter

will be True if the Autofilter controls are showing.

home and finding that young Toba’s broken another toy or impatiently directing Toba’s attention to yet another vital fact he’s failed to spot.

This argument comes to a head early in Episode 4, in a much more tense mirror of a scene in Episode 2, both set in the Dominators’ incredibly groovy spaceship control room. In that earlier scene, the Dominators subject the Doctor and Jamie to a series of physical and intelligence tests, a disturbing sequence that might tip into unpleasantly sadistic but for Patrick Troughton and Frazer Hines’ inspired ability to clown around and make things entertaining. Toba, on the other hand, is not one of nature’s jollifiers (despite providing some mirth by apparently peering up Jamie’s kilt in Episode 2). The drama when Toba oversteps the


var cell = document.createElement('td');
            cell.setAttribute('height', 20);
            cell.setAttribute('width', 20);
            cell.classList.add('col' + j, 'row' + i);
            cell.identifier = identifier; // <-------
            row.appendChild(cell);
            identifier += identifier;// <--------this is the problem
        }
    }

    document.getElementById("main").appendChild(board);
}

A:

First of all, instead of custom properties you should use data attributes and instead of the width and height attributesyou should use CSS. Second, you were incrementing identifier by itself, so it wouldn't grow from 0.

const GRID_SIZE = 6;

function init() {
    var board = document.createElement('table');
    board.setAttribute("border", 1);
    board.setAttribute("cellspacing", 0);
    board.setAttribute("id", 'tbl');

    var identifier = 0;
    for (var i = 0; i < GRID_SIZE; i++) {
        var row = document.createElement('tr');
        board.appendChild(row);
        for (var j = 0; j < GRID_SIZE; j++) {
            var cell = document.createElement('td');
            cell.dataset.identifier =


Presentation Description

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Deciding to move to Australia is a life-changing decision. It involves significant financial and emotional investments from you and your family and it is vital you have confidence in the professionalism and integrity of your Migration Agent.

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PowerPoint Presentation:

Australian Immigration

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Australian visa

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For Further Information On Please Take A Look On Australian Immigration http://www.visamagnet.com/see, but there’s a much better chance of it happening this season than there has been in years past.

Most importantly, Inter remain unbeaten and their three most difficult fixtures are in the books

Despite all of what’s said above this… the only thing that really matters from Saturday’s match is that Inter remained undefeated on the season. The fact that we’re now 16 matches into the Serie A campaign and Inter have yet to lose is beyond the wildest dreams of most supporters.

It’s also worth noting that Inter’s unbeaten run includes arguably the three most difficult fixtures in Italian football; Juventus, Napoli, and AS Roma away. Not only have Inter taken five points from those three matches, but they’ve also conceded just one goal… That’s simply phenomenal given how


disappointing and mentally fragile the club have been in recent seasons.

As fans, we may not be thrilled with the performance Inter showed against Juventus in Saturday’s Derby D’Italia — Luciano Spalletti most certainly won’t be — but at the end of the day, Inter remain undefeated well into December. That’s more than every other team in Italy can say.

Forza Inter!Sound production evoked by electrical stimulation of the forebrain in the oyster toadfish.
In mammals, birds and amphibians the neural pathways controlling sound production descend from higher centers in the forebrain, whereas in fishes only brainstem and spinal centers have been explicitly implicated in sound production. We now report that electrical stimulation of the forebrain of the oyster toadfish (Opsanus tau) readily evokes both the agonistic grunt and the courtship boatwhistle. Boatwhistles are more realistic than ones previously evoked from lower centers. Positive stimulation sites are localized in the preoptic area (nucleus preopticus parvocellularis anterior) and the supra-commissural nucleus of the ventral telencephalon, a likely homologue of the amygdala. Both sites contain gonadal steroid-concentrating neurons and play a central role in fish courtship behavior. Evoked sounds form a continuum


the array.
$rootDir = ""; //Root directory where your image files are located
$file = fopen("filehandle.csv", "r"); //Open the old file for reading
$newFile = fopen("newfilehandle.csv", "w"); //Create a new file for writing

while (($data = fgetcsv($file)) !== FALSE) {
    $row = array_combine($columns, $data);
    $filename = "{$row['sku']}.jpeg";
    if (file_exists("$rootDir/$filename")) {
        $row['image'] = $filename;
        $row['small_image'] = $filename;
        $row['thumbnail'] =  $filename;
    }
    fputcsv($newFile, array_values($row)); //write data into new file
}

fclose($file);
fclose($newFile);

Now you have a copy of the original file with the new values inserted.

lightmap
	vec3f vNormal;		///< vertex normale
	unsigned char bColor[ 4 ];			///< Color in RGBA
};

///	A face in bsp format info
struct sQ3BSPFace
{
	int iTextureID;					///< Index in texture array
	int iEffect;					///< Index in effectarray (-1 = no effect)
	int iType;						///< 1=Polygon, 2=Patch, 3=Mesh, 4=Billboard
	int iVertexIndex;				///< Start index of polygon
	int iNumOfVerts;				///< Number of vertices
	int	iFaceVertexIndex;			///< Index of first mesh vertex
	int iNumOfFaceVerts;			///< Anzahl der Meshvertices
	int iLightmapID;				///< Index to the lightmap array
	int iLMapCorner[ 2 ];			///< Die Ecke der Lightmap in der Textur
	int iLMapSize[ 2 ];				///< Size of the lightmap stored on the texture
	vec3f vLMapPos;					///< 3D-Ursprung der Lightmap
	vec3f vLMapVecs[ 2 ];			///< 3D-s-t-Vektoren
	vec3f vNormal;					///< Polygonnormale
	int patchWidth, patchHeight;	///< bezier patch
};

/// A quake3 texture name.
struct sQ3BSPTexture
{
	char strName[ 64 ];		///< Name of the texture without extention
	int iFlags;				///< Not used
	int iContents;			///< Not used
};

///	A lightmap of the level, size 128 x 128, RGB components.
struct sQ3BSPLightmap
{
	unsigned


The ontogeny of hypothalamic pituitary function in the pig. I. Pituitary LH and FSH in the fetus and neonate.
Pituitaries were collected from fetal and postnatal pigs from day 55 p.c. until 6 weeks after birth at closely spaced intervals. LH and FSH in individual pituitaries were quantified by both homologous RIA and homologous RRA. No significant difference was found between results obtained by RIA and RRA. Both LH and FSH are first detected by RIA and RRA in the porcine fetal pituitary at 75 days p.c. Thereafter both LH and FSH pituitary content rises until term. LH pituitary concentration in both male and female fetuses and FSH pituitary concentration in males exhibit a peak just before birth. FSH pituitary concentration in females rises until birth and thereafter remains  AS RUNNING,
  COALESCE(STILL,0)      AS STILL,
  COALESCE(TILTING,0)    AS TILTING,
  COALESCE("UNKNOWN",0)  AS "UNKNOWN",
  COALESCE(WALKING,0)    AS WALKING
FROM crosstab(
    'SELECT (end_user_id || ''_'' || tms) AS row_id, type, confidence
    FROM activities
    ORDER BY row_id, type, confidence',
    'SELECT DISTINCT type FROM activities order by type'
    ) AS newtable (
            end_user_id text,
            IN_VEHICLE  int,
            ON_BICYCLE  int,


History is written by the winners.

Overused cliche line that doesn't mean anything and isn't true. The Soviets
won World War 2, they won it more than the USA won World War 2 and more than
the British or anybody else won World War 2 but we re-wrote their history as
evil scumbags who committed atrocities during the war.

~~~
bdunbar
> we re-wrote their history as evil scumbags who committed atrocities during
> the war.

Re-writing was not needed. Stalin was an evil thug, just as bad in minor ways
as Hitler.

~~~
nikcub
News of the massacre of thousands of Polish officers in Katyn in 1940[0] by
the Soviet Union was hushed up by the Western Allies during the various 3-body
conferences. It only came out after the war and when Cold War tension rose[1]

Contrast this to when Dachau was liberated,measuring the gaseous products which are liberated; PA1 (b) the utilization of differential thermal analysis which measures the heat of the reactive exotherm when solid blowing agents are employed; PA1 (c) thermal gravimetric analysis for measuring weight loss as a function of temperature (utilizing solid or liquid blowing agents); and PA1 (d) the employment of mixers such as a miniature Banbury, to measure the viscous properties of a polymeric melt as calculated from torque measurements.
The preceding methods (a), (b) and (c) are deficient in that the blowing agent decomposition behavior is determined under conditions which bear no relation to actual extrusion processes. With respect to method (d), the measurement of elastic turbulance of this type can not be directly related with processability.
Accordingly, for accurate determination of rheological properties,


The present invention relates to a surgical mesh and, more particularly, to a soft and pliable multifilament surgical support mesh exhibiting improved resistance to inhabitation of bacteria and other infectious matter.
Using surgical mesh for the repair and restoration of living tissue is well known. For example, surgical mesh may be used to support and/or reinforce a damaged or weakened portion of the body. In this regard, the mesh must additionally be sufficiently porous to allow for growth of tissue through the graft after implantation. The healing tissue grows through porous openings in the implanted mesh, thereby assimilating the mesh and adding structural integrity to the tissue.
Surgical mesh may be produced by knitting, weaving, braiding, or otherwise forming a plurality of yarns into a support trellis. Moreover, such meshadministration was seemingly bent on eliminating them all. With real estate scarce, I imagine the gardens’ time is numbered. Many of the gardens have their origins in the teardowns, or even burndowns, of unwanted buildings by their owners in the 1970s.

These don’t look particularly inviting in January when I shot them, but they are well cared for in growng season.

We have of course paid a great deal of attention to the plight of histroic St. Saviour’s Church in Maspeth, which has been in the crosshairs of a developer for years and stands on the edge of the precipice in March 2008, but St. Brigid’s at Avenue B and East 8th is in the same boat.

St. Brigid’s may in fact be the oldest Patrick Keely church still standing. Its


[Save St. Brigid]

The archdiocese says the church needs to be torn down because the structure is in danger of collapsing.

Basilio Scientific School, a private church it seems; above: ad palimpsest on East 7th and B: a catering hall and a funeral parlor. The Horseshoe Bar on the ground floor has seen scenes from ”The Godfather: Part II”, ”Crocodile Dundee”, ”Cocktail” and “Rent” shot there.

Soon after completing the page I heard from Larry Kirwan himself, who writes,

I used to live on Ave. B and 3rd Street and take my word for it, the neighborhood was quite dangerous. Still, it was home and I loved it. Should you want more information on the area, take a read of my “memoir”, Green Suede Shoes. It’s available in most big book storesset certificate verify locations:
*   CAfile: none
  CApath: /etc/ssl/certs
* SSLv3, TLS handshake, Client hello (1):
* SSLv3, TLS alert, Server hello (2):
* error:1408F10B:SSL routines:SSL3_GET_RECORD:wrong version number
* Closing connection #0

My virtualhost is configured as thus (fragment):
    SSLEngine on
    SSLProtocol all -SSLv2
    SSLCipherSuite ALL:!ADH:!EXPORT:!SSLv2:RC4+RSA:+HIGH:+MEDIUM

    SSLCertificateFile    /etc/apache2/ssl.key/xxx/ssl.cert
    SSLCertificateKeyFile /etc/apache2/ssl.key/xxx/xxx.xxx.key

    #   Server Certificate Chain:
    SSLCertificateChainFile /etc/apache2/ssl.key/sub.class1.server.ca.pem

    #   Certificate Authority (CA):
    SSLCACertificateFile /etc/apache2/ssl.key/ca.pem

    <FilesMatch "\.(cgi|shtml|phtml|php)$">
            SSLOptions +StdEnvVars
    </FilesMatch>
    <Directory /usr/lib/cgi-bin>


who made the booking. All cost incurred due to amendment will be borne by you.

If you have a complaint

If you face any problem during your holiday, please inform the relevant supplier (e.g. your hotelier, transporter etc.) and/or our representative immediately who will endeavour to set things right. If your complaint is not resolved locally, please follow this up within 28 days of your return home by writing to us, with your booking reference and all other relevant information. However, please be advised that while we are happy to assist you in the redressal of your complaint, if any, we will be able to extend only our best efforts in managing/coordinating your complaint with the respective service provider. All third party service providers are independent contractors who are atactual requirements are. This can mean just a few extra sales calls beyond your quota, or working for an extra 30 minutes before shutting down.

By putting in a little more effort than required you can start getting the attention of your superiors or clients, get more done during the workday and feel a new energizing sense of motivation and satisfaction.

8. Improve in one area each day.

This area can be something small or large and it can be in your personal or professional life, but make it a goal to improve in one area of your life every day. This can be improving your jogging speed while you work out, getting more emails done in a certain time period or improving on your elevator pitch.

No matter what it is,


Check with your service provider regarding any fees or costs associated with texting.

The library is not responsible for any charges assessed by the user's cell phone service provider.

Text a Librarian uses the same security protocols as online banking. Patron phone numbers are kept private. Text-a-Librarian technology is mobile carrier-certified, ensuring message delivery and security. For more information please contact the public library.

Text Set Up
To begin texting a librarian, begin by texting "Start" to 412-685-4004. You will receive instructions for use. Once you have done this, you may text that number directly with questions and for assistance.

Acceptable Texts
Review the following information on what you can text and what is acceptable for using text messaging:

Any type of question.

Texting is meant to provide short, just-in-time answers.

You may be directed to emailSchizotypy is associated with the belief in conspiracy theories, according to new research published in the journal Psychiatry Research.

“My main research interest is in schizotypy. Schizotypy is a personality organisation that can be seen as risk factor for schizophrenia-spectrum disorders,” explained study author David Barron of Perdana University. “However, with the concept of schizophrenia breaking down, psychologists, such as myself, are increasingly investigating schizotypy.”

“Schizotypic traits have a similar pattern to that of schizophrenia; that is, deficits in cognition, socio-emotional function, and behaviour. While these tend not meet the clinical threshold, and at some level represent a healthy personality make-up, they can be rather extreme and become a severe problem.”

“This paper sought to build on our previous work by linking facets of schizotypy with conspiracy ideation, but also to


line with contemporary theorising of conspiracy ideation, some caution should be exercised when interpreting causational effects.

“While inferences from these data can only be made through the sub-clinical schizotypal view, patients with psychotic disorders and those with an at-risk mental state, have also been shown to have reasoning biases or abnormalities,” Barron added. “Therefore, future research should consider not only reasoning biases, but an outcome of conspiracy beliefs through both clinical and sub-clinical expression of schizotypy.”

“It is important to mention that for the most part, schizotypy reflects a normal, healthy, personality and associated issues are only at the high-end of scorers.”

The study, “The Relationship Between Schizotypal Facets and Conspiracist Beliefs via Cognitive Processes“, was co-authored by Adrian Furnham, Laura Weis, Kevin D. Morgan, Tony Towell, and Viren Swami.some ways it reminds me of Twelfth Night, a Shakespeare style of comedy. It has a lot of hijinks, the romance, and it all comes together at the end."

Mamma Mia! returns to Sydney just as another Abba-soaked musical, Muriel's Wedding the Musical, has finished its sold-out season (with another run booked for 2019). Meanwhile, waiting in the wings in Priscilla Queen of Dessert, which opens in May and also has a soundtrack that leans heavily on the Swedish supergroup.

What is it with all the Abba love?

"The music has such honesty to it," says O'Donnell. "I've reflected on it quite a bit, and I just think it was all about the music for them.

"Outside of the music world, they were just four very normal people who valued family and


utility and will satisfy one or the other customer. So, what are you still waiting for?

Do not even worry if you do not find your favorite men’s hoodie type in the right color or design, because we can customize it for you. Our custom mens hoodie collection is one of the best in the business and each of the products are made using the latest methods in the manufacturing industry and the highest quality of fabric.

They are subjected to many levels of quality checks, so that each of your designs are printed indelibly on the kind of hoodies you want. Once you have taken a look at the collection, you can find even add in your own design ideas and our professionals are going to make sure thatHaagsche Courant

The Haagsche Courant operated as an independent newspaper between 1864 and 2005 in The Hague and its suburbs. After it was acquired by the Algemeen Dagblad (AD) it is now published as AD Haagse Courant, written by local staff and the AD crew.

History
The paper appeared as early as 1864 as the Belinfante edition, but remained continuously under the control of the Sijthoff family for over 120 years since Albert Georg Sijthoff in 1883. The Sijthoff publishing company was attacked by car bomb after the newspaper printed a negative article about business activities in the 1980s by a collection agency owned by Dutch criminal Eef Hoos.

The paper remained an independent publication until 2005 when it merged with the Algemeen Dagblad, along with Rijn en Gouwe, Rotterdams Dagblad, De


is only touched once, rather than N times as in the trivial implementation. As a result, after sorting, the algorithm is N times faster!! For large M and N, this is a huge difference! As you said in other comment, this code will be called millions of times, then we definitely want O(M) algorithm instead of O(MN) algorithm.
Also note, that the memory costs for this approach is O(M + N), i.e., we only concatenate two vectors together, rather than expanding it into an M-by-N matrix. So such storage saving is also noticeable.
In fact, we can take one step further, by converting this comparison problem into a matching problem, which is easier to vectorize in R.
## version 1:
CCDD <- c(CC, DD) ## combine CC and DD
CCDD <- sort(CCDD, decreasingsecurity needs vis-a-vis Syria and Lebanon, and will not deal with the Israeli-Palestinian peace process," the White House official said. "The delegation's arrival in Washington is a powerful sign of the trust between Israel and McMaster.

Prime Minister Benjamin Netanyahu's Office said in response that the delegation's departure was part of routine security talks between Israel and the U.S.

Open gallery view H.R. McMaster, national security advisor, arrives to attend a joint statement with U.S. President Donald Trump and Moon Jae-in, South Korea's president, not pictured, in the Rose Garden of the White H Credit: Andrew Harrer/Bloomberg

One of the main issues that the Israeli delegation is expected to discuss in the talks is the cease-fire agreement in southern Syria and its ramifications. Israel is dissatisfied with the fact that its


security interests were not reflected in the draft cease-fire agreement being formulated by the United States and Russia. A senior Israeli official said the delegation was expected to try to persuade senior administration officials that parts of the cease-fire agreement in southern Syria should be amended to include clearer statements about the need to remove Iranian forces, Hezbollah and Shi'ite militias out of Syria.

Mossad chief Cohen said in a security briefing to the government on Sunday that so far Israel's positions were not reflected in the cease-fire agreement in southern Syria, noting specifically the presence of Iranian forces in Syria. "In places where the presence of ISIS is limited, Iran is acting to fill the void," he told the ministers. A few hours later, at a conference inoptode contact with the scalp was identified by taking the root mean square of the raw data when the signal magnitude was more than 10 times the average signal and removed automatically.

### 2.4.2. General linear model analysis {#sec2.4.2}

Previous NIRS studies have typically focused on analyses of neural activity as reflected by the OxyHb signal due to its large amplitude and higher signal-to-noise ratio.[@r16] However, recent studies have demonstrated that the deOxyHb signal shows a higher correlation to the hemodynamic response measured through the BOLD signal using fMRI,[@r22] may better represent neural activity, and contains less systemic artifact than the OxyHb signal.[@r23]^,^[@r24] While we used the OxyHb signal to provide feedback to participants, analyses described here representing neural activity in response to either active or imagined tasks are based


real and imaginary motor tasks and tasks performed with and without neurofeedback. Interpolated anatomical locations of peak voxel activity were identified using NIRS_SPM.[@r26]^,^[@r27]

### 2.4.3. Small volume analysis {#sec2.4.3}

A small volume analysis was performed on voxelwise results using the functional cluster determined from right-handed ball squeezing in the contralateral motor area. The cluster of activity used to generate the functional mask is circled in black in [Fig. 5(a)](#f5){ref-type="fig"}. Signal processing related to neurofeedback was restricted within this small volume during right-handed ball squeezing with neurofeedback as well as during the two imagined task conditions (with and without neurofeedback).

![Factorial comparisons showing neural activity during active motor tasks (a, c) and imagined motor tasks (b, d) without neurofeedback (a, b) and with neurofeedback (c, d) ($N = 22$, $p < 0.01$). Onlyincreased activity compared with nonneurofeedback runs, indicating that if there was an effect of habituation, the activity for neurofeedback runs could be even greater than shown here. The imaginary squeezing runs also always followed the real squeezing runs. Decreased activity due to habituation may explain the lack of results during the imaginary squeezing without neurofeedback condition.

Another limitation of the current study was the presence of physiological noise in the real-time OxyHb signal presented to the participants. Future studies incorporating a real-time global mean removal algorithm[@r24] should be conducted in order to determine the effects of a more localized and specific neurofeedback on the participant's neural circuitry associated with motor imagery tasks.

6. Conclusion {#sec6}
=============

The current study demonstrates the potential of fNIRS as a platform for the development of real-time


Yale School of Medicine, and a professor of neuroscience, University College London. She is director of the Brain Function Laboratory at Yale. Her research focuses on neural circuitry that underlies human social interactions using multimodal neuroimaging: fNIRS, fMRI, EEG, eye-tracking, and behavioral measures. Prior to recruitment to Yale she was a director of the fMRI Research Center at Columbia.
Introduction {#s1}
============

Spatial covariance analysis of scans of resting cerebral function provides a useful way to characterize specific network abnormalities in a variety of neurodegenerative disorders [@pone.0088119-Eidelberg1]--[@pone.0088119-Niethammer1]. This approach has been particularly valuable in elucidating the systems-level changes in cerebral function that underlie hypokinetic movement disorders such as Parkinson's disease (PD) [@pone.0088119-Eidelberg1], [@pone.0088119-Niethammer1], as well as atypical variant conditions such as progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) [@pone.0088119-Eckert1], [@pone.0088119-Poston1]. Moreover, spatial covariance patterns can be used in combination to differentiate these clinically similar conditions based upon their characteristic metabolic topographies [@pone.0088119-Spetsieris2], [@pone.0088119-Tang1]. Despite consistent evidence that the expression of these disease-related covariance patterns is independent in individual subjects, scant information exists concerning the actual relationship of the topographies between any two topographies.

To assess similarities and differences


PDRP and previously characterized metabolic patterns associated with MSA and PSP, the two most common parkinsonian "look-alike" conditions. In addition, we also compared PDRPs derived from five different PET centers from USA, Netherlands, China, India and South Korea.

Methods {#s2}
=======

Imaging protocols and pattern characterization procedures are described elsewhere [@pone.0088119-Eidelberg1], [@pone.0088119-Spetsieris1], [@pone.0088119-Eckert1], [@pone.0088119-Poston1], [@pone.0088119-Ma1]. A tutorial on the use of this covariance approach has appeared recently [@pone.0088119-Spetsieris4].

Topographical Correlation {#s2a}
-------------------------

Similarities/differences between the PDRP [@pone.0088119-Ma1], MSA-related pattern (MSARP) [@pone.0088119-Eckert1], [@pone.0088119-Poston1] and PSP-related pattern (PSPRP) [@pone.0088119-Eckert1], and PDRPs from four different countries (i.e., USA, Netherlands, China and India) [@pone.0088119-Niethammer1] were evaluated by computing the percent of the overall variance shared (r2) between the non-zero voxel weights on each pair of topographies [@pone.0088119-Mure1], [@pone.0088119-Spetsieris3], [@pone.0088119-Ko1]. Voxels from each pattern image were formatted into aso, the calculations took 1--4 weeks to perform, depending on the degree of autocorrelation estimated for the various patterns (Intel(R) Core(TM) i7-2600 CPU 3.40 GHz, 8.00 GB RAM, 64-bit Windows 7 Professional). Clearly, further research to optimize the computational process is warranted.

The authors wish to thank Dr. Thomas Chaly and Mr. Claude Margouleff for technical support and Ms. Patricia J Allen, Yoon Young Choi and Toni Fitzpatrick for valuable assistance with manuscript preparation/editing. We also thank Drs K.L. Leenders, L.K. Teune, C. Zuo, M. Tripathi and C. Lee for generously sharing FDG PET scans from their respective institutions. These data were essential for the comparison of the PDRPs from four different countries presented in Table 3 and regional difference map computation in Figure 2.

[^1]: **Competing Interests:**The authors have


currently able to take advantage of our Adaptive Training Plans: it depends.

“The benefit of my Omegawave Adaptive Training Plan is that not only is there a sound program in place, but there is a great plan B,” Mahon adds. “By being able to use the Omegawave daily readings the training plan will adapt to you. We are no longer stuck with a rigid program that does not fit or adapt to the athlete response. Our program will have an answer each day to how you should train based on your goals and your training response. This is a feature that has never been available before on any other training program on the market. The ultimate training program must include individual variability, and now we have it with thefacility in addition to the administrative approval required of all SWD facilities regardless of size.  Legislative approval was conditioned upon a finding that the facility was environmentally safe and in the public interest.  Under South Dakota law, the Secretary of State is required to publish a pamphlet containing an Attorney General's explanation of, S.D.Codified Laws Sec. 12-13-9 (1982 & Supp.1994), and public comment on, S.D. Codified Laws Sec. 12-13-23 (1982 & Supp.1994), each initiated or referred measure.  South Dakota stated at oral argument that this pamphlet is part of the legislative history of these initiated and referred measures.  The Attorney General's explanation of the November 1990 initiative stated that it would apply retroactively to existing facilities (i.e., the Lonetree facility), and that only one


113 S.Ct. 977, 122 L.Ed.2d 131 (1993).

19
At the second step of the analysis, we apply the appropriate level of scrutiny.  The Supreme Court has established two levels of scrutiny.  The determinative factor is the presence or absence of discrimination against interstate commerce.  If the state measure is discriminatory, it is subjected to the "strictest scrutiny," Oregon Waste Sys., Inc. v. Department of Envtl.  Quality of the State of Oregon, --- U.S. ----, ----, 114 S.Ct. 1345, 1351, 128 L.Ed.2d 13 (1994) (quoting Hughes, 441 U.S. at 337, 99 S.Ct. at 1736-37), and a "virtually per se rule of invalidity" applies.  Oregon Waste Sys., --- U.S. at ----, 114 S.Ct. at 1351 (quoting Philadelphia, 437 U.S. at 624, 98 S.Ct. at 2535-36);  Southeasttherefore hold that South Dakota's referendum of S.B. 169 violates the dormant aspects of the commerce clause of the United States Constitution.

III. CONCLUSION

37
We hold that South Dakota's referral of S.B. 169 violated the dormant commerce clause.  Although facially neutral, the referendum had a discriminatory purpose and a sufficiently discriminatory effect to trigger strict scrutiny.  Because we find that the referendum does not appreciably advance any legitimate local interest, and that nondiscriminatory alternatives are available to advance South Dakota's legitimate concerns, the referendum does not survive strict scrutiny.  Accordingly, the judgment of the district court is reversed and we remand to the district court with instructions to enter judgment in favor of SDDS.

1
 We express no view as to the merits of the due process or


and expensive to accomplish.  The absence of a reapplication to the BME is not fatal.  See Diamond Waste, Inc. v. Monroe County, Ga., 939 F.2d 941, 943 (11th Cir.1991) (applying Pike test to invalidate county's disallowance of landfill, despite absence of application required by statute)

11
 SDDS III found that 90% of the waste would originate outside South Dakota.  Slip op. at 3.  SDDS makes similar claims

12
 The fact that only 90% rather than 100% of the costs of excluding the waste fall on out-of-staters does not eliminate the discriminatory effect.  This fact merely reduces the scope of the discrimination.  Fort Gratiot, ---- U.S. at ----, 112 S.Ct. at 2025;  Waste Sys. Corp., 985 F.2d at 1387 n. 11.   TheLamp Lighters
In keeping with the article by the previous rebbi (?) called "Lamp Lighters" that describes what a Chassid is - it was particularly poignant to hear Dr. Block, in my eyes the quintessential Lamp Lighter, retell this story about his Rebbi!
Reply

My job description
What a wonderful explanation the Rebbe gave about what his "job" was. Everything is so plausible, you are able to see the current of electricity right in front of your eyes, when it starts at Niagarafall, how it is going its way through the wires to its destined place, and we have only to switch the light on...Without doing that, there is darkness. We only have to switch G-ds light on, as we put the light on for a lamp.And He, the Rebbe, tells, where


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This round is capable of providing high-level accuracy and boasts a devastating performance. Many use these excellent bullets for small game and varmint hunting. The rounds are capable of taking animals down in one shot due to their expansion on impact and fast, terminal performance.that he has all wisdom, and all power, both in heaven and in earth.”

“Believe that man doth not comprehend all the things which the Lord can comprehend” (Mosiah 4:9).

This layout helps to show that Benjamin’s three statements explain what it means to “believe in God.”

This passage also summarizes things Benjamin had already told the people.1 He began his summary by telling the people to believe in God, whom he had promised to help his people understand in the first sentence of his speech (Mosiah 2:9). He then told them to believe that God created all things in heaven and earth. Earlier, he had taught that Jesus Christ was “the Father of heaven and earth, the Creator of all things from the beginning” (Mosiah 3:8, emphasis added). Mosiah 4:9


His thoughts higher than man’s thoughts.6

Doctrine and Principles

As King Benjamin himself said, obeying the commands he laid down in Mosiah 4:9 are the only “conditions whereby man can be saved” (Mosiah 4:8).7 The fact that King Benjamin chose this statement to summarize much of his speech shows how important he thought these points were. One can easily see why. If God “created all things,” “has all wisdom, and all power,” and can comprehend things human beings can’t, then “in our search for truth, we can trust Him completely, relying on His wisdom, His love, and His power to teach and bless us. God knows all things and is the source of all truth.”8

People cannot understand everything that God can understand, just like a small child cannot understand everythinghis father can understand. They must therefore be “willing to submit to all things which the Lord seeth fit to inflict upon him, even as a child doth submit to his father” (Mosiah 3:19). This submission to God shows faith that “He is perfect, has all power, and knows all things. He is also just, merciful, and kind.”9 People must come to know that God knows best and that they can always trust Him, even when they do not always understand Him.10

King Benjamin also showed that a nebulous belief in God cannot produce this intense kind of faith. One must not only “believe in God” (Mosiah 4:9). They must also believe that “he created all things,” that “he has all wisdom, and all power,” and “that man doth


{
                TriggerOnDeath = true,
                TriggerAmount = 1,
                SoundToPlay = ContentPaths.Audio.Oscar.sfx_oc_chicken_hurt_1
            }).SetFlag(Flag.ShouldSerialize, false);

            Physics.AddChild(new ParticleTrigger("feather", Manager, "Death Gibs", Matrix.Identity, Vector3.One, Vector3.Zero)
            {
                TriggerOnDeath = true,
           to match the desired scale without waiting, and on scale down will delete
	// all pods at once.
	// +optional
	PodManagementPolicy PodManagementPolicyType `json:"podManagementPolicy,omitempty" protobuf:"bytes,6,opt,name=podManagementPolicy,casttype=PodManagementPolicyType"`

	// updateStrategy indicates the StatefulSetUpdateStrategy that will be
	// employed to update Pods in the StatefulSet when a revision is made to
	// Template.
	UpdateStrategy StatefulSetUpdateStrategy `json:"updateStrategy,omitempty" protobuf:"bytes,7,opt,name=updateStrategy"`

	// revisionHistoryLimit is the maximum number of revisions that will
	// be maintained in the StatefulSet's revision history. The revision history
	// consists of all revisions not represented by a currently applied
	// StatefulSetSpec version. The default value is 10.
	RevisionHistoryLimit *int32 `json:"revisionHistoryLimit,omitempty" protobuf:"varint,8,opt,name=revisionHistoryLimit"`
}

// StatefulSetStatus represents the current state of a StatefulSet.
type StatefulSetStatus struct {
	// observedGeneration is the most recent generation observed for this StatefulSet. It corresponds to the
	// StatefulSet's generation, which is updated on mutation by the API Server.
	// +optional
	ObservedGeneration int64 `json:"observedGeneration,omitempty" protobuf:"varint,1,opt,name=observedGeneration"`

	// replicas is the number


of Pods created by the StatefulSet controller.
	Replicas int32 `json:"replicas" protobuf:"varint,2,opt,name=replicas"`

	// readyReplicas is the number of Pods created by the StatefulSet controller that have a Ready Condition.
	ReadyReplicas int32 `json:"readyReplicas,omitempty" protobuf:"varint,3,opt,name=readyReplicas"`

	// currentReplicas is the number of Pods created by the StatefulSet controller from the StatefulSet version
	// indicated by currentRevision.
	CurrentReplicas int32 `json:"currentReplicas,omitempty" protobuf:"varint,4,opt,name=currentReplicas"`

	// updatedReplicas is the number of Pods created by the StatefulSet controller from the StatefulSet version
	// indicated by updateRevision.
	UpdatedReplicas int32 `json:"updatedReplicas,omitempty" protobuf:"varint,5,opt,name=updatedReplicas"`

	// currentRevision, if not empty, indicates the version of the StatefulSet used to generate Pods in the
	// sequence [0,currentReplicas).
	CurrentRevision string `json:"currentRevision,omitempty" protobuf:"bytes,6,opt,name=currentRevision"`

	// updateRevision, if not empty, indicates the version of the StatefulSet used to generate Pods in the sequence
	// [replicas-updatedReplicas,replicas)
	UpdateRevision string `json:"updateRevision,omitempty" protobuf:"bytes,7,opt,name=updateRevision"`

	// collisionCount is the count of hash collisions for the StatefulSet. The StatefulSet controller
	// uses thisdeployment.
	// It must match the pod template's labels.
	Selector *metav1.LabelSelector `json:"selector" protobuf:"bytes,2,opt,name=selector"`

	// Template describes the pods that will be created.
	Template v1.PodTemplateSpec `json:"template" protobuf:"bytes,3,opt,name=template"`

	// The deployment strategy to use to replace existing pods with new ones.
	// +optional
	// +patchStrategy=retainKeys
	Strategy DeploymentStrategy `json:"strategy,omitempty" patchStrategy:"retainKeys" protobuf:"bytes,4,opt,name=strategy"`

	// Minimum number of seconds for which a newly created pod should be ready
	// without any of its container crashing, for it to be considered available.
	// Defaults to 0 (pod will be considered available as soon as it is ready)
	// +optional
	MinReadySeconds int32 `json:"minReadySeconds,omitempty" protobuf:"varint,5,opt,name=minReadySeconds"`

	// The number of old ReplicaSets to retain to allow rollback.
	// This is a pointer to distinguish between explicit zero and not specified.
	// Defaults to 10.
	// +optional
	RevisionHistoryLimit *int32 `json:"revisionHistoryLimit,omitempty" protobuf:"varint,6,opt,name=revisionHistoryLimit"`

	// Indicates that the deployment is paused.
	// +optional
	Paused bool `json:"paused,omitempty" protobuf:"varint,7,opt,name=paused"`

	// The maximum time in seconds for


value is 1.
	// Example: when this is set to 30%, at most 30% of the total number of nodes
	// that should be running the daemon pod (i.e. status.desiredNumberScheduled)
	// can have their pods stopped for an update at any given
	// time. The update starts by stopping at most 30% of those DaemonSet pods
	// and then brings up new DaemonSet pods in their place. Once the new pods
	// are available, it then proceeds onto other DaemonSet pods, thus ensuring
	// that at least 70% of original number of DaemonSet pods are available at
	// all times during the update.
	// +optional
	MaxUnavailable *intstr.IntOrString `json:"maxUnavailable,omitempty" protobuf:"bytes,1,opt,name=maxUnavailable"`
}

// DaemonSetSpec is the specification of a daemon set.
type DaemonSetSpec struct {
	// A label query over pods that are managed by the daemon set.
	// Must match in order to becontrolled.
	// It must match the pod template's labels.
	// More info: https://kubernetes.io/docs/concepts/overview/working-with-objects/labels/#label-selectors
	Selector *metav1.LabelSelector `json:"selector" protobuf:"bytes,1,opt,name=selector"`

	// An object that describes the pod that will be created.
	// The DaemonSet will create exactly one copy of this pod on every node
	// that matches the template's node selector (or on every node if no node
	// selector is specified).
	// More info: https://kubernetes.io/docs/concepts/workloads/controllers/replicationcontroller#pod-template
	Template v1.PodTemplateSpec `json:"template" protobuf:"bytes,2,opt,name=template"`

	// An update strategy to replace existing DaemonSet pods with new pods.
	// +optional
	UpdateStrategy DaemonSetUpdateStrategy `json:"updateStrategy,omitempty" protobuf:"bytes,3,opt,name=updateStrategy"`

	// The minimum number of seconds for which a newly created DaemonSet pod should
	// be ready without any of its container crashing, for it to be considered
	// available. Defaults to 0 (pod will be considered available as soon as it
	// is ready).
	// +optional
	MinReadySeconds int32 `json:"minReadySeconds,omitempty" protobuf:"varint,4,opt,name=minReadySeconds"`

	// The number of old history to retain to allow


rollback.
	// This is a pointer to distinguish between explicit zero and not specified.
	// Defaults to 10.
	// +optional
	RevisionHistoryLimit *int32 `json:"revisionHistoryLimit,omitempty" protobuf:"varint,6,opt,name=revisionHistoryLimit"`
}

// DaemonSetStatus represents the current status of a daemon set.
type DaemonSetStatus struct {
	// The number of nodes that are running at least 1
	// daemon pod and are supposed to run the daemon pod.
	// More info: https://kubernetes.io/docs/concepts/workloads/controllers/daemonset/
	CurrentNumberScheduled int32 `json:"currentNumberScheduled" protobuf:"varint,1,opt,name=currentNumberScheduled"`

	// The number of nodes that are running the daemon pod, but are
	// not supposed to run the daemon pod.
	// More info: https://kubernetes.io/docs/concepts/workloads/controllers/daemonset/
	NumberMisscheduled int32 `json:"numberMisscheduled" protobuf:"varint,2,opt,name=numberMisscheduled"`

	// The total number of nodes that should be running the daemon
	// pod (including nodes correctly running the daemon pod).
	// More info: https://kubernetes.io/docs/concepts/workloads/controllers/daemonset/
	DesiredNumberScheduled int32 `json:"desiredNumberScheduled" protobuf:"varint,3,opt,name=desiredNumberScheduled"`

	// The number of nodes that should be running the daemon pod and have one
	// or more of the daemon podset.
type DaemonSet struct {
	metav1.TypeMeta `json:",inline"`
	// Standard object's metadata.
	// More info: https://git.k8s.io/community/contributors/devel/sig-architecture/api-conventions.md#metadata
	// +optional
	metav1.ObjectMeta `json:"metadata,omitempty" protobuf:"bytes,1,opt,name=metadata"`

	// The desired behavior of this daemon set.
	// More info: https://git.k8s.io/community/contributors/devel/sig-architecture/api-conventions.md#spec-and-status
	// +optional
	Spec DaemonSetSpec `json:"spec,omitempty" protobuf:"bytes,2,opt,name=spec"`

	// The current status of this daemon set. This data may be
	// out of date by some window of time.
	// Populated by the system.
	// Read-only.
	// More info: https://git.k8s.io/community/contributors/devel/sig-architecture/api-conventions.md#spec-and-status
	// +optional
	Status DaemonSetStatus `json:"status,omitempty" protobuf:"bytes,3,opt,name=status"`
}

const (
	// DefaultDaemonSetUniqueLabelKey is the default label key that is added
	// to existing DaemonSet pods to distinguish between old and new
	// DaemonSet pods during DaemonSet template updates.
	DefaultDaemonSetUniqueLabelKey = ControllerRevisionHashLabelKey
)

// +k8s:deepcopy-gen:interfaces=k8s.io/apimachinery/pkg/runtime.Object

// DaemonSetList is a collection of daemon sets.
type DaemonSetList struct {
	metav1.TypeMeta `json:",inline"`
	// Standard list metadata.
	// More info: https://git.k8s.io/community/contributors/devel/sig-architecture/api-conventions.md#metadata
	// +optional
	metav1.ListMeta `json:"metadata,omitempty" protobuf:"bytes,1,opt,name=metadata"`

	// A list of daemon sets.
	Items []DaemonSet `json:"items" protobuf:"bytes,2,rep,name=items"`
}

// +genclient
// +k8s:deepcopy-gen:interfaces=k8s.io/apimachinery/pkg/runtime.Object

// DEPRECATED - This group version of ReplicaSet is deprecated by


human readable message indicating details about the transition.
	// +optional
	Message string `json:"message,omitempty" protobuf:"bytes,5,opt,name=message"`
}

// +genclient
// +k8s:deepcopy-gen:interfaces=k8s.io/apimachinery/pkg/runtime.Object

// DEPRECATED - This group version of ControllerRevision is deprecated by apps/v1/ControllerRevision. See the
// release notes for more information.
// ControllerRevision implements an immutable snapshot of state data. Clients
// are responsible for serializing and deserializing the objects that contain
// their internal state.
// Once a ControllerRevision has been successfully created, it can not be updated.
// The API Server will fail validation of all requests that attempt to mutate
// the Data field. ControllerRevisions may, however, be deleted. Note that, due to its use by both
// the DaemonSet and StatefulSet controllers for update and rollback, this object is beta. However,
// it may be subject to name and representation changes in future releases, and clients should not
// depend on itssystem \[[@CR49], [@CR50]\], one of the few unifying institutions across the USAPI/HI/AK, provided a suitable infrastructure for regional collaboration. The CHL Program was developed in response to the United States Department of Agriculture (USDA) Agriculture and Food Research Initiative to develop a multi-state/jurisdiction, multi-institutional, and multi-disciplinary team to integrate knowledge about child nutrition, physical activity, and social and environmental influences on childhood obesity in order to develop and implement a large-scale, multifaceted, community-based, and environmentally-focused intervention for preventing early childhood obesity (ages 2--8 years).

The overall goal of the CHL program is to strengthen the children's environments to better promote active play and intake of healthy food in order to prevent early childhood obesity in the USAPI/HI/AK, which are located in the northern Pacific Ocean (except American Samoa). For CHL,


community meeting discussion questions by constituent group (e.g., parents, teachers, and community leaders)Parents1What does a healthy young child look like to you?Follow-upWhat keeps a young child healthy?2Where are fruits and vegetables available in your community?3What helps young children to eat more fruit and vegetables in your community?Follow-upWhat makes it hard for children in the community to eat fruits and vegetables?Follow-upWhat can you do to help young children eat more fruits and vegetables, at home? At school?Follow-upWhat can we do to increase young children eating more fruits and vegetables at home? At school?4What are some of the reasons that less healthy foods are chosen over the healthy foods in your community?Follow-upWhat kinds of healthy foods, like fruits and vegetables, are available in your community that could be eaten insteadin the community would help parents and young children to eat healthy? Be more active?Follow-upWhat would be an ideal community program that would increase your child's physical activity? Improve his/her eating habits?Follow-upCan you share some ways that you have been successful in getting your children to eat healthy? Be active?Teachers1What words would you use to describe a healthy young child at your school/program?2Describe how the food choices of the young children in your school/program affect their health right now?Follow-upDescribe how the current eating habits of young children in your school/program will affect their health in the future?3What changes can be made in your school/program to get young children to:a. Eat more fruits and vegetables?b. Drink more water?c. Get children to drink less sugar-sweetened beverages?4What kind of healthy foods,


recommend to lower young children's screen viewing time, or time spent in front of the TV, computers, computer games, in order to allow more opportunity for other activities such as active play?10What needs to be done to promote healthy living (eating healthy and being active) for young children in your community?Follow-upWhat do you think would be the ideal strategy to increase active play in your school/program? Healthy eating?11What more can your school/program do to increase healthy food availability in your community? Physical activity?Community leaders1How does your community promote healthy eating and physical activity for young children?Follow-upWhat are some examples of community activities or strategies that promote health?Follow-upWhat would you like to see in your community to improve and/or promote healthy eating and physical activity?2What can you do orencoded) {
  const unsigned char* const ptr =
      reinterpret_cast<const unsigned char*>(&encoded);
  return uint64_t{ptr[0]} | (uint64_t{ptr[1]} << 8) |
         (uint64_t{ptr[2]} << (2 * 8)) | (uint64_t{ptr[3]} << (3 * 8)) |
         (uint64_t{ptr[4]} << (4 * 8)) | (uint64_t{ptr[5]} << (5 * 8)) |
         (uint64_t{ptr[6]} << (6 * 8)) | (uint64_t{ptr[7]} << (7 * 8));
}

inline uint16_t DecodeBigEndian16(uint16_t encoded) {
  const unsigned char* const ptr =
      reinterpret_cast<const unsigned char*>(&encoded);
  return (uint16_t{ptr[0]} << 8) | uint16_t{ptr[1]};
}

inline uint32_t DecodeBigEndian32(uint32_t encoded) {
  const unsigned char* const ptr =
      reinterpret_cast<const unsigned


eukaryotes that processes premature mRNA into multiple mature isoforms, thus affecting mRNA stability and increasing transcriptome complexity and protein diversity (Black, [@B6]; Simpson et al., [@B59]). AS is involved in plant growth and development (Romanowski and Yanovsky, [@B50]; Srinivasan et al., [@B62]; Wang et al., [@B74]) and adaptation to abiotic and biotic stresses (Schliebner et al., [@B55]; Ren et al., [@B49]; Keller et al., [@B33]; Thatcher et al., [@B67]; Jiang et al., [@B28]). Recently, in response to the lepidopteran chewing insect *Manduca sexta*, 180 and 356 differentially spliced genes were identified in the roots and leaves of the wild tobacco *Nicotiana attenuata*, respectively, suggesting a role of AS in regulating plant defense against lepidopteran insects (Ling et al., [@B37]). However, whether and how AS is involved in plantthe contents of Bxs in either line. Another group of metabolites that we examined were the phenolics. The contents of phenolics also showed large differences between B73 and Mo17. Without *R. padi* treatment, 10 phenolic compounds, apigenin O-hexoside, apigenin C-hexoside C-pentoside, quercetin O-hexoside, quercetin O-deoxyhexosyl-hexoside, luteolin, luteolin O-hexoside, luteolin O-hexoside O-deoxyhexoside, neochlorogenic acid, isorhamnetin O-hexoside, and isorhamnetin O-rhamnoglycoside were 0.64--3.29-fold higher in B73 than in Mo17, while the content of scytalone was 34.9% lower in B73 (Figure [2B](#F2){ref-type="fig"}, Table [S1](#SM1){ref-type="supplementary-material"}). After 48 h of *R. padi* feeding, most phenolics decreased in B73 (39--77%), but remained constant in Mo17.

![Profiles of Bxs and phenolics in B73 and Mo17. Maize leaves were treated with *R. padi* herbivory, and samples were collected at 48 h; non-treated leaves severed as controls (0 h).


three clusters) and 958 transcripts in Mo17 (in two clusters) with significant expression profile changes for at least one time-point after the *R. padi* feeding. The total number of transcripts in each cluster is indicated in the brackets, and the data for individual genes are shown in light gray. Average expression values for each cluster are shown in red. All genes selected for this analysis have significant differences of 1-fold (up- or down-regulated), *P* \< 0.05. **(B)** Pathway enrichment analysis of each cluster using MetGenMAP to identify metabolic functions that were regulated. Full descriptions can be found in Table [S4](#SM4){ref-type="supplementary-material"}.](fpls-08-01738-g0004){#F4}

In order to gain further insight into the regulatory mechanism underlying the differences between the responses of B73 and Mo17 to *R. padi* on the gene expression level, differentiallyThe fourth maize leaves were each treated with 50 aphids, and samples were collected at 6 and 24 h after *R. padi* treatment; untreated leaves served as controls. **(A)** Venn diagram depicting the number of transcription factors (TFs) significantly changed in B73 and Mo17 after 6 and 24 h of *R. padi* treatment. Heat maps indicate relative expression levels (fold change after log~2~ transformation) of TFs regulated by *R. padi* feeding in B73 **(B)** and Mo17 **(C)**. **(D)** Relative expression levels (fold change after log~2~ transformation) of the 9 common regulated TFs in B73 and Mo17. Detailed data can be found in Table [S5](#SM5){ref-type="supplementary-material"}.](fpls-08-01738-g0005){#F5}

Clustering of expression patterns in B73 and Mo17
-------------------------------------------------

Given the large gene expression differences between B73 and Mo17 in response to *R. padi* feeding, we expected


B73 and Mo17 under control, 6 and 24 h of aphid herbivory indicated that only very few genes were regulated on both expression and AS level (Figures [10A--C](#F10){ref-type="fig"}, Tables [S6](#SM6){ref-type="supplementary-material"}, [S10](#SM10){ref-type="supplementary-material"}). It is likely that AS and gene expression are regulated largely independent in maize response to aphid feeding. This is consistent with a study on AS events in the response of *N. attenuata* to the chewing caterpillar *M. sexta*, where 5 h of *M. sexta* feeding induced 180 and 356 DSGs in leaves and roots, respectively, and there was only little overlap (31 genes in leaves and six genes in roots) between differentially expressed and DSGs in both leaves and roots (Ling et al., [@B37]). After *R. padi* feeding, B73 and Mo17 had only some genes thatwere DSGs at both 6 and 24 h (Figures [9C,F](#F9){ref-type="fig"}, Table [S9](#SM9){ref-type="supplementary-material"}), indicating a highly time-specific regulation of AS. The finding that B73 and Mo17 have many specific DSGs under control and *R. padi*-feeding conditions (Figure [10D](#F10){ref-type="fig"}, Table [S10](#SM10){ref-type="supplementary-material"}) also suggest an important role of AS in diversifying the specific responses to *R. padi* infestation on different maize lines. A growing body of evidence has revealed that AS influences gene functions in plants. For example, the FLK protein influences flowering time in *Arabidopsis*, and FLK in prmt5 mutants (impaired in AS regulation) cannot be normally spliced, resulting in a late flowering phenotype (Pei et al., [@B45]; Deng et al., [@B15]); PRR9 is a core-clock gene, which influences the circadian rhythm in *Arabidopsis*, and altered splicing of PRR9 caused


an impairment of the circadian clock (Sanchez et al., [@B54]); JAZ proteins play an important role in repressing jasmonic acid signaling. AS of JAZ10 produces different splice variants, and JA-induced JAZ10.4 protein accumulation has been suggested to be an important feedback regulator to mediate JA signal desensitization (Moreno et al., [@B42]). Further functional studies on the different spliced isoforms of alternatively spliced genes are needed to understand if and how AS regulates maize responses to aphid herbivory.

Taken together, our large-scale data analyses revealed highly distinct metabolic and transcriptomic features in B73 and Mo17, and the differences remained large after aphid *R. padi* feeding (Figure [11](#F11){ref-type="fig"}). Furthermore, we identified a group of TFs that might contribute to the different resistance to *R. padi* by regulating the accumulation of Bxs.look. She treats her patients with extreme care and ends the consultation in a way that leaves a smile on your face! She is a pan-India speaker for Cosmetic Dentistry in the dental fraternity & is on the panel of Mr. & Miss. Personality Pune.

iSmyle is conceptualized to be the best dental care clinic with state-of-the-art facilities. It is the brainchild and a combined creation of two minds, two thought processes and two qualifications.


raid on Osama bin Laden’s presumed compound, in Abbottabad, Pakistan—and then shows how the people in charge drew upon insights from “decision science,” a research field at the intersection of behavioral economics, psychology, and management. He thinks that we should apply such techniques to our own lives.

I’ve never had to decide whether to launch a covert raid on a suspected terrorist compound, but I’ve made my share of big decisions. This past summer, my wife and I had a baby boy. His existence suggests that, at some point, I decided to become a father. Did I, though? I never practiced any prudential algebra; rather than drawing up lists of pros and cons and concluding, on balance, that having kids was a good idea, I gradually and unintentionally transitioned                           Pasadena, California

Before: REINHARDT, HAWKINS, and GOULD, Circuit Judges.

       The Estate of Erma V. Jorgensen (the “Estate”) appeals the tax court’s

affirmance of the Commissioner of the Internal Revenue’s (“Commissioner”)

         *
           This disposition is not appropriate for publication and is not precedent
except as provided by Ninth Circuit Rule 36-3.
assessment of an estate tax deficiency. Concluding that certain transfers decedent had

made to two family limited partnerships should remain included in the estate

valuation, the tax court found that decedent had retained


Alex Konanykhin, a man who made and then lost a fortune in Russia, Brian Haig has crafted a tale of intrigue and suspense that is not only highly entertaining but also quite topical. Strange things like this still happen in what was once the Soviet Union.     private final SimpleStringProperty name;
        private final SimpleStringProperty email;

        private Person(final String fName, final String email)
        {
            this.name = new SimpleStringProperty(fName);
            this.email = new SimpleStringProperty(email);
        }

        public String getName()
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biventricular mechanics in the intact dog by simultaneous measurements of left and right ventricular pressures and volumes. A computer algorithm will use the positional information obtained from radiopaque markers implanted on the ventricular endocardial surface to calculate the ventricular volumes. Using this preparation the effects of respiration, posture, pericardial pressure, pressure overload, and volume overload on biventricular function will be examined. The information obtained in this study will provide new insight into ventricular mechanics in normal and pathological conditions, and will improve the understanding of the mechanisms which produce right ventricular dysfunction.Benjamin O. Davis Sr.

Benjamin Oliver Davis Sr. (1880 – November 26, 1970) was a United States Army officer. He became the first African-American to rise to the rank of Brigadier General in the U.S. military in 1940. He was the father of Air Force General Benjamin O. Davis Jr.

Early life and education
Davis was born in Washington, D.C., the third child of Louis P. H. Davis and Henrietta (née Stewart) Davis. Biographer Marvin Fletcher has presented evidence that Davis was born in May 1880, citing a June 1880 census document. Fletcher concludes that Davis lied about his age so that he could enlist in the army without the permission of his parents. The birth date that appears on Davis's gravestone at Arlington National Cemetery is July 1, 1877, the


121)/((-6)/4). Suppose 6 = -7*p + s. Suppose p = 3*l - f, -l = -4*l + 5*f - 10. Solve -l*v = 8 + 2 for v.
-2
Suppose -7 + 4 = o. Let r(a) = -a**2 - 4*a - 2. Let n be r(o). Suppose n = -2*j + 31. Solve 5*b - j = 2*b for b.
5
Suppose -5*h = 2*x - 8, 310*h - 4*x - 32 = 308*h. Let o = 15 + -13. Solve -o*z - 4 = h for z.
-4
Suppose -8 = -u + 5*u. Let f(b) = 12*b + 10. Let v be f(u). Let s be (28/v)/((-1)/2). Solve -7 = -s*d + 13 for d.
5
Suppose -4*b + 560 = 18*j - 14*j, -3*b + 415 = 4*j. Solve -2*i + bsecond position at the coin market cap as market doesn’t understood what the reality is . But little by little market will reject buying ripple as there is nothing in it except that it is centralized and this is his biggest BUG!

Bitcoin is to reach 100 Million Dollars. 💰 Is it sounds like a fairy tale? Might be, but time will show. 🕑

What is more fantastic is that there is the “Letter from the Future” in the internet that predicted the price of Bitcoin till now and predicted that North Korea started to mine Bitcoin from May 2017. Not literally, but it says that North Korea is the state in future that holds the most of Bitcoins (180000 BTC)

At this video I am making the technical analyze of